                         SEQUENCE LISTING

<110>  Hvidovre Hospital
       Kbenhavns Universitet
       Li, Yiping
       Scheel, Troels  Kasper Hyer
       Ramirez, Santseharay
       Gottwein, Judith M
       Bukh, Jens
 
<120>  HCV full-length infectious cell culture systems and applications 
       thereof

<130>  49561PC01

<150>  61/613,138
<151>  2012-03-20

<150>  61/722,675
<151>  2012-11-05

<160>  158   

<170>  PatentIn version 3.5

<210>  1
<211>  9678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  1
acctgcccct aataggggcg acactccgcc atgaatcact cccctgtgag gaactactgt       60

cttcacgcag aaagcgccta gccatggcgt tagtatgagt gtcgtacagc ctccaggccc      120

ccccctcccg ggagagccat agtggtctgc ggaaccggtg agtacaccgg aattgccggg      180

aagactgggt cctttcttgg ataaacccac tctatgcccg gccatttggg cgtgcccccg      240

caagactgct agccgagtag cgttgggttg cgaaaggcct tgtggtactg cctgataggg      300

cgcttgcgag tgccccggga ggtctcgtag accgtgcacc atgagcacaa atcctaaacc      360

tcaaagaaaa accaaaagaa acaccaaccg tcgcccacaa gacgttaagt ttccgggcgg      420

cggccagatc gttggcggag tatacttgtt gccgcgcagg ggccccaggt tgggtgtgcg      480

cgcgacaagg aagacttcgg agcggtccca gccacgtgga aggcgccagc ccatccctaa      540

agatcggcgc tccactggca aatcctgggg aaaaccagga tacccctggc ccctatacgg      600

gaatgaggga ctcggctggg caggatggct cctgtccccc cgaggttccc gtccctcttg      660

gggccccaat gacccccggc ataggtcgcg caacgtgggt aaggtcatcg ataccctaac      720

gtgcggcttt gccgacctca tggggtacat ccctgtcgtg ggcgccccgc tcggcggcgt      780

cgccagagct ctcgcgcatg gcgtgagagt cctggaggac ggggttaatt ttgcaacagg      840

gaacttaccc ggttgctcct tttctatctt cttgctggcc ctgctgtcct gcatcaccac      900

cccggtctcc gctgccgaag tgaagaacat cagtaccggc tacatggtga ctaacgactg      960

caccaatgac agcattacct ggcagctcca ggctgctgtc ctccacgtcc ccgggtgcgt     1020

cccgtgcgag aaagtgggga atgcatctca gtgctggata ccggtctcac cgaatgtggc     1080

cgtgcagcgg cccggcgccc tcacgcaggg cttgcggacg cacatcgaca tggttgtgat     1140

gtccgccacg ctctgctctg ccctctacgt gggggacctc tgcggtgggg tgatgctcgc     1200

agcccaaatg ttcattgtct cgccgcagca ccactggttt gtccaagact gcaattgctc     1260

catctaccct ggtaccatca ctggacaccg catggcatgg gacatgatga tgaactggtc     1320

gcccacggct accatgatct tggcgtacgc gatgcgtgtc cccgaggtca ttatagacat     1380

cattagcggg gctcattggg gcgtcatgtt cggcttggcc tacttctcta tgcagggagc     1440

gtgggcgaaa gtcgttgtca tccttctgtt ggccgccggg gtggacgcgc gcacccatac     1500

tgttgggggt tctgccgcgc agaccaccgg gcgcctcacc agcttatttg acatgggccc     1560

caggcagaaa atccagctcg ttaacaccaa tggcagctgg cacatcaacc gcaccgccct     1620

gaactgcaat gactccttgc acaccggctt tatcgcgtct ctgttctaca cccacagctt     1680

caactcgtca ggatgtcccg aacgcatgtc cgcctgccgc agtatcgagg ccttccgggt     1740

gggatggggc gccttgcaat atgaggataa tgtcaccaat ccagaggata tgagacccta     1800

ttgctggcac tacccaccaa ggcagtgtgg cgtggtctcc gcgaagactg tgtgtggccc     1860

agtgtactgt ttcaccccca gcccagtggt agtgggcacg accgacaggc ttggagcgcc     1920

cacttacacg tggggggaga atgagacaga tgtcttccta ttgaacagca ctcgaccacc     1980

gctggggtca tggttcggct gcacgtggat gaactcttct ggctacacca agacttgcgg     2040

cgcaccaccc tgccgtacta gagctgactt caacgccagc acggacctgt tgtgccccac     2100

ggactgtttt aggaagcatc ctgataccac ttacctcaaa tgcggctctg ggccctggct     2160

cacgccaagg tgcctgatcg actaccccta caggctctgg cattacccct gcacagttaa     2220

ctataccatc ttcaaaataa ggatgtatgt gggaggggtt gagcacaggc tcacggctgc     2280

atgcaatttc actcgtgggg atcgttgcaa cttggaggac agagacagaa gtcaactgtc     2340

tcctttgttg cactccacca cggaatgggc cattttacct tgctcttact cggacctgcc     2400

cgccttgtcg actggtcttc tccacctcca ccaaaacatc gtggacgtac aattcatgta     2460

tggcctatca cctgccctca caaaatacat cgtccgatgg gagtgggtaa tactcttatt     2520

cctgctctta gcggacgcca gggtttgcgc ctgcttatgg atgctcatct tgttgggcca     2580

ggccgaagca gcactagaga agctggtcat cttgcacgct gcgagcgcag ctagctgcaa     2640

tggcttccta tattttgtca tctttttcgt ggctgcttgg tacatcaagg gtcgggtagt     2700

ccccttagct acctattccc tcactggcct gtggtccttt agcctactgc tcctagcatt     2760

gccccaacag gcttatgctt atgacgcatc tgtgcatggc cagataggag cggctctgct     2820

ggtaatgatc actctcttta ctctcacccc cgggtataag acccttctca gccggttttt     2880

gtggtggttg tgctatcttc tgaccctggg ggaagctatg gtccaggagt gggcaccacc     2940

tatgcaggtg cgcggtggcc gtgatggcat catatgggcc gtcgccatat tctacccagg     3000

tgtggtgttt gacataacca agtggctctt ggcggtgctt gggcctgctt acctcctaaa     3060

aggtgctttg acgcgcgtgc cgtacttcgt cagggctcac gctctactga ggatgtgcac     3120

catggcaagg catctcgcgg ggggcaggta cgtccagatg gcgctactag cccttggcag     3180

gtggactggc acttacatct atgaccacct cacccctatg tcggattggg ctgctagtgg     3240

cctgcgggac ctggcggtcg ccgttgagcc tatcatcttc agtccgatgg agaagaaagt     3300

cattgtctgg ggagcggaga cagctgcttg tggggacatt ttacacggac ttcccgtgtc     3360

cgcccgactt ggtcgggagg tcctccttgg cccagctgat ggctatacct ccaaggggtg     3420

gagtcttctc gctcccatca ctgcttatgc ccagcaaaca cgaggcctcc tgggcgccat     3480

agtggtgagt atgacggggc gtgacaggac agaacaggcc ggggaagtcc aaatcctgtc     3540

cacagtctct cagtccttcc tcggaacaac catctcgggg gttttgtgga ctgtttacca     3600

cggagctggc aacaagactc tagccggctt acggggtccg gtcacgcaga tgtactcgag     3660

tgctgagggg gacttggtag gctggcccag cccccctggg accaagtctt tggagccgtg     3720

caagtgtgga gccgtcgacc tatatctggt cacgcggaac gctgatgtca tcccggctcg     3780

gagacgcggg gacaagcggg gagcattgct ctccccgaga cccatttcga ccttgaaggg     3840

gtcctcgggg gggccggtgc tctgccctag gggccacgtc gttgggctct tccgagcagc     3900

tgtgtgctct cggggcgtgg ccaaatccat cgatttcatc cccgttgaga cactcgacgt     3960

tgttacaagg tctcccactt tcagtgacaa cagcacgcca ccggctgtgc cccagaccta     4020

tcaggtcggg tacttgcatg ctccaactgg cagtggaaag agcaccaagg tccctgtcgc     4080

gtatgccgcc caggggtaca aagtactagt gcttaacccc tcggtagctg ccaccctggg     4140

gtttggggcg tacctatcca aggcacatgg catcaatccc aacattagga ctggagtcag     4200

gaccgtgatg accggggagg ccatcacgta ctccacatat ggcaaatttc tcgccgatgg     4260

gggctgcgct agcggcgcct atgacatcat catatgcgat gaatgccacg ctgtggatgc     4320

tacctccatt ctcggcatcg gaacggtcct tgatcaagca gagacagccg gggtcagact     4380

aactgtgctg gctacggcca caccccccgg gtcagtgaca accccccatc ccgatataga     4440

agaggtaggc ctcgggcggg agggtgagat ccccttctat gggagggcga ttcccctatc     4500

ctgcatcaag ggagggagac acctgatttt ctgccactca aagaaaaagt gtgacgagct     4560

cgcggcggcc cttcggggca tgggcttgaa tgccgtggca tactatagag ggttggacgt     4620

ctccataata ccagctcagg gagatgtggt ggtcgtcgcc accgacgccc tcatgacggg     4680

gtacactgga gactttgact ccgtgatcga ctgcaatgta gcggtcaccc aagctgtcga     4740

cttcagcctg gaccccacct tcactataac cacacagact gtcccacaag acgctgtctc     4800

acgcagtcag cgccgcgggc gcacaggtag aggaagacag ggcacttata ggtatgtttc     4860

cactggtgaa cgagcctcag gaatgtttga cagtgtagtg ctttgtgagt gctacgacgc     4920

aggggctgcg tggtacgatc tcacaccagc ggagaccacc gtcaggctta gagcgtattt     4980

caacacgccc ggcctacccg tgtgtcaaga ccatcttgaa ttttgggagg cagttttcac     5040

cggcctcaca cacatagacg cccacttcct ctcccaaaca aagcaagcgg gggagaactt     5100

cgcgtaccta gtagcctacc aagctacggt gtgcgccaga gccaaggccc ctcccccgtc     5160

ctgggacgcc atgtggaagt gcctggcccg actcaagcct acgcttgcgg gccccacacc     5220

tctcctgtac cgtttgggcc ctattaccaa tgaggtcacc ctcacacacc ctgggacgaa     5280

gtacatcgcc acatgcatgc aagctgacct tgaggtcatg accagcacgt gggtcctagc     5340

tggaggagtc ctggcagccg tcgccgcata ttgcctggcg actggatgcg tttccatcat     5400

cggccgcttg cacgtcaacc agcgagtcgt cgttgcgccg gataaggagg tcctgtatga     5460

ggcttttgat gagatggagg aatgcgcctc tagggcggct ctcatcgaag aggggcagcg     5520

gatagccgag atgttgaagt ccaagatcca aggcttgctg cagcaggcct ctaagcaggc     5580

ccaggacata caacccgcta tgcaggcttc atggcccaaa gtggaacaat tttgggccag     5640

acacatgtgg aacttcatta gcggcatcca atacctcgca ggattgtcaa cactgccagg     5700

gaaccccgcg gtggcttcca tgatggcatt cagtgccgcc ctcaccagtc cgttgtcgac     5760

cagtaccacc atccttctca acatcatggg aggctggtta gcgtcccaga tcgcaccacc     5820

cgcgggggcc accggctttg tcgtcagtgg cctggtgggg gctgccgtgg gcagcatagg     5880

cctgggtaag gtgctggtgg acatcctggc aggatatggt gcgggcattt cgggggccct     5940

cgtcgcattc aagatcatgt ctggcgagaa gccctctatg gaagatgtca tcaatctact     6000

gcctgggatc ctgtctccgg gagccctggt ggtgggggtc atctgcgcgg ccattctgcg     6060

ccgccacgtg ggaccggggg agggcgcggt ccaatggatg aacaggctta ttgcctttgc     6120

ttccagagga aaccacgtcg cccctactca ctacgtgacg gagtcggatg cgtcgcagcg     6180

tgtgacccaa ctacttggct ctcttactat aaccagccta ctcagaagac tccacaattg     6240

gataactgag gactgcccca tcccatgcgg cggctcgtgg ctccgcgatg tgtgggactg     6300

ggtttgcacc atcctaacag actttaaaaa ttggctgacc tccaaattat tcccaaagat     6360

gcccggcctc ccctttgtct cctgtcaaaa ggggtacaag ggcgtgtggg ccggcactgg     6420

catcatgacc acacggtgtc cttgcggcgc caatatctct ggcaatgtcc gcttgggctc     6480

catgagaatc acggggccta agacctgcat gaatatctgg caggggacct ttcctatcaa     6540

ttgttacacg gagggccagt gcgtgccgaa acccgcgcca aactttaagg tcgccatctg     6600

gagggtggcg gcctcagagt acgcggaggt gacgcagcac gggtcatacc actacataac     6660

aggactcacc actgataact tgaaagtccc ctgccaacta ccctctcccg agttcttttc     6720

ctgggtggac ggagtgcaga tccataggtt tgcccccaca ccgaagccgt ttttccggga     6780

tgaggtctcg ttctgcgttg ggcttaattc atttgtcgtc gggtcccagc ttccttgcga     6840

ccctgaaccc gacacagacg tattgatgtc catgctaaca gatccatctc atatcacggc     6900

ggagactgca gcgcggcgtt tagcgcgggg gtcaccccca tccgaggcaa gctcctcggc     6960

gagccagcta tcggcaccat cgctgcgagc cacctgcacc acccacggca aagcctatga     7020

tgtggacatg gtggatgcta acctgttcat ggggggcgat gtgactcgga tagagtctgg     7080

gtccaaagtg gtcgttctgg actctctcga cccaatggtc gaagaaagga gcgaccttga     7140

gccttcgata ccatcagaat acatgctccc caagaagagg ttcccaccag ctttaccggc     7200

ctgggcacgg cctgattaca acccaccgct tgtggaatcg tggaaaaggc cagattacca     7260

accggccact gttgcgggct gtgctctccc tcctcctagg aaaaccccga cgcctccccc     7320

aaggaggcgc cggacagtgg gcctaagtga ggactccata ggagatgccc ttcaacagct     7380

ggccattaag tcctttggcc agcccccccc aagcggcgat tcaggccttt ccacgggggc     7440

gggcgctgcc gattccggca gtcagacgcc tcctgatgag ttggcccttt cggagacagg     7500

ttccatctct tccatgcccc ccctcgaggg ggagcttgga gatccagacc tggagcctga     7560

gcaggtagag ccccaacccc ccccccaggg gggggtggca gctcccggct cggactcggg     7620

gtcctggtct acttgctccg aggaggacga ctccgtcgtg tgctgctcca tgtcatactc     7680

ctggaccggg gctctaataa ctccttgtag tcccgaagag gagaagttac cgattaaccc     7740

cttgagcaac tccctgttgc gatatcacaa caaggtgtac tgtaccacaa caaagagcgc     7800

ctcactaagg gctaaaaagg taacttttga taggatgcaa gtgctcgact cctactacga     7860

ctcagtctta aaggacatta agctagcggc ctccaaggtc accgcaaggc tcctcaccat     7920

ggaggaggct tgccagttaa ccccacccca ttctgcaaga tctaaatatg ggtttggggc     7980

taaggaggtc cgcagcttgt ccgggagggc cgttaaccac atcaagtccg tgtggaagga     8040

cctcctggag gactcagaaa caccaattcc cacaaccatt atggccaaaa atgaggtgtt     8100

ctgcgtggac cccaccaagg ggggcaagaa agcagctcgc cttatcgttt accctgacct     8160

cggcgtcagg gtctgcgaga agatggccct ttatgacatt acacaaaaac ttcctcaggc     8220

ggtgatggga gcttcctatg gcttccagta ctcccctgcc caacgggtgg agtatctctt     8280

gaaagcatgg gcggaaaaga aggaccccat gggtttttcg tatgataccc gatgcttcga     8340

ctcaaccgtc actgagagag acatcaggac cgaggagtcc atataccagg cctgctccct     8400

gcccgaggag gcccgcactg ccatacactc gctgactgag agactttacg taggagggcc     8460

catgttcaac agcaagggtc aaacctgcgg ttacagacgt tgccgcgcca gcggggtgct     8520

aaccactagc atgggtaaca ccatcacatg ctatgtgaaa gccctagcgg cctgcaaggc     8580

tgcggggata gttgcgccca caatgctggt atgcggcgat gacctagtag tcatctcaga     8640

aagccagggg actgaggagg acgagcggaa cctgagagcc ttcacggagg ccatgaccag     8700

gtactctgcc cctcctggtg atccccccag accggaatat gacctggagc taataacatc     8760

ctgttcctca aatgtgtctg tggcgttggg cccgcggggc cgccgcagat actacctgac     8820

cagagaccca accactccac tcgcccgggc tgcctgggaa acagttagac actcccctat     8880

caattcatgg ctgggaaaca tcatccagta tgctccaacc atatgggttc gcatggtcct     8940

aatgacacac ttcttctcca ttctcatggt ccaagacacc ctggaccaga acctcaactt     9000

tgagatgtat ggatcagtat actccgtgaa tcctttggac cttccagcca taattgagag     9060

gttacacggg cttgacgcct tttctatgca cacatactct caccacgaac tgacgcgggt     9120

ggcttcagcc ctcagaaaac ttggggcgcc acccctcagg gtgtggaaga gtcgggctcg     9180

cgcagtcagg gcgtccctca tctcccgtgg agggaaagcg gccgtttgcg gccgatatct     9240

cttcaattgg gcggtgaaga ccaagctcaa actcactcca ttgccggagg cgcgcctact     9300

ggacttatcc agttggttca ccgtcggcgc cggcgggggc gacatttttc acagcgtgtc     9360

gcgcgcccga ccccgctcat tactcttcgg cctactccta cttttcgtag gggtaggcct     9420

cttcctactc cccgctcggt agagcggcac acactaggta cactccatag ctaactgttc     9480

cttttttttt tttttttttt tttttttttt tttttttttt ttttcttttt tttttttttc     9540

cctctttctt cccttctcat cttattctac tttctttctt ggtggctcca tcttagccct     9600

agtcacggct agctgtgaaa ggtccgtgag ccgcatgact gcagagagtg ccgtaactgg     9660

tctctctgca gatcatgt                                                   9678


<210>  2
<211>  9678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  2
acctgcccct aataggggcg acactccgcc atgaatcact cccctgtgag gaactactgt       60

cttcacgcag aaagcgccta gccatggcgt tagtatgagt gtcgtacagc ctccaggccc      120

ccccctcccg ggagagccat agtggtctgc ggaaccggtg agtacaccgg aattgccggg      180

aagactgggt cctttcttgg ataaacccac tctatgcccg gccatttggg cgtgcccccg      240

caagactgct agccgagtag cgttgggttg cgaaaggcct tgtggtactg cctgataggg      300

cgcttgcgag tgccccggga ggtctcgtag accgtgcacc atgagcacaa atcctaaacc      360

tcaaagaaaa accaaaagaa acaccaaccg tcgcccacaa gacgttaagt ttccgggcgg      420

cggccagatc gttggcggag tatacttgtt gccgcgcagg ggccccaggt tgggtgtgcg      480

cgcgacaagg aagacttcgg agcggtccca gccacgtgga aggcgccagc ccatccctaa      540

agatcggcgc tccactggca aatcctgggg aaaaccagga tacccctggc ccctatacgg      600

gaatgaggga ctcggctggg caggatggct cctgtccccc cgaggttccc gtccctcttg      660

gggccccaat gacccccggc ataggtcgcg caacgtgggt aaggtcatcg ataccctaac      720

gtgcggcttt gccgacctca tggggtacat ccctgtcgtg ggcgccccgc tcggcggcgt      780

cgccagagct ctcgcgcatg gcgtgagagt cctggaggac ggggttaatt ttgcaacagg      840

gaacttaccc ggttgctcct tttctatctt cttgctggcc ctgctgtcct gcatcaccac      900

cccggtctcc gctgccgaag tgaagaacat cagtaccggc tacatggtga ctaacgactg      960

caccaatgac agcattacct ggcagctcca ggctgctgtc ctccacgtcc ccgggtgcgt     1020

cccgtgcgag aaagtgggga atgcatctca gtgctggata ccggtctcac cgaatgtggc     1080

cgtgcagcgg cccggcgccc tcacgcaggg cttgcggacg cacatcgaca tggttgtgat     1140

gtccgccacg ctctgctctg ccctctacgt gggggacctc tgcggtgggg tgatgctcgc     1200

agcccaaatg ttcattgtct cgccgcagca ccactggttt gtccaagact gcaattgctc     1260

catctaccct ggtaccatca ctggacaccg catggcatgg gacatgatga tgaactggtc     1320

gcccacggct accatgatct tggcgtacgc gatgcgtgtc cccgaggtca ttatagacat     1380

cattagcggg gctcattggg gcgtcatgtt cggcttggcc tacttctcta tgcagggagc     1440

gtgggcgaaa gtcgttgtca tccttctgtt ggccgccggg gtggacgcgc gcacccatac     1500

tgttgggggt tctgccgcgc agaccaccgg gcgcctcacc agcttatttg acatgggccc     1560

caggcagaaa atccagctcg ttaacaccaa tggcagctgg cacatcaacc gcaccgccct     1620

gaactgcaat gactccttgc acaccggctt tatcgcgtct ctgttctaca cccacagctt     1680

caactcgtca ggatgtcccg aacgcatgtc cgcctgccgc agtatcgagg ccttccgggt     1740

gggatggggc gccttgcaat atgaggataa tgtcaccaat ccagaggata tgagacccta     1800

ttgctggcac tacccaccaa ggcagtgtgg cgtggtctcc gcgaagactg tgtgtggccc     1860

agtgtactgt ttcaccccca gcccagtggt agtgggcacg accgacaggc ttggagcgcc     1920

cacttacacg tggggggaga atgagacaga tgtcttccta ttgaacagca ctcgaccacc     1980

gctggggtca tggttcggct gcacgtggat gaactcttct ggctacacca agacttgcgg     2040

cgcaccaccc tgccgtacta gagctgactt caacgccagc acggacctgt tgtgccccac     2100

ggactgtttt aggaagcatc ctgataccac ttacctcaaa tgcggctctg ggccctggct     2160

cacgccaagg tgcctgatcg actaccccta caggctctgg cattacccct gcacagttaa     2220

ctataccatc ttcaaaataa ggatgtatgt gggaggggtt gagcacaggc tcacggctgc     2280

atgcaatttc actcgtgggg atcgttgcaa cttggaggac agagacagaa gtcaactgtc     2340

tcctttgttg cactccacca cggaatgggc cattttacct tgctcttact cggacctgcc     2400

cgccttgtcg actggtcttc tccacctcca ccaaaacatc gtggacgtac aattcatgta     2460

tggcctatca cctgccctca caaaatacat cgtccgatgg gagtgggtaa tactcttatt     2520

cctgctctta gcggacgcca gggtttgcgc ctgcttatgg atgctcatct tgttgggcca     2580

ggccgaagca gcactagaga agctggtcat cttgcacgct gcgagcgcag ctagctgcaa     2640

tggcttccta tattttgtca tctttttcgt ggctgcttgg tacatcaagg gtcgggtagt     2700

ccccttagct acctattccc tcactggcct gtggtccttt agcctactgc tcctagcatt     2760

gccccaacag gcttatgctt atgacgcatc tgtgcatggc cagataggag cggctctgct     2820

ggtaatgatc actctcttta ctctcacccc cgggtataag acccttctca gccggttttt     2880

gtggtggttg tgctatcttc tgaccctggg ggaagctatg gtccaggagt gggcaccacc     2940

tatgcaggtg cgcggtggcc gtgatggcat catatgggcc gtcgccatat tctacccagg     3000

tgtggtgttt gacataacca agtggctctt ggcggtgctt gggcctgctt acctcctaaa     3060

aggtgctttg acgcgcgtgc cgtacttcgt cagggctcac gctctactga ggatgtgcac     3120

catggcaagg catctcgcgg ggggcaggta cgtccagatg gcgctactag cccttggcag     3180

gtggactggc acttacatct atgaccacct cacccctatg tcggattggg ctgctagtgg     3240

cctgcgggac ctggcggtcg ccgttgagcc tatcatcttc agtccgatgg agaagaaagt     3300

cattgtctgg ggagcggaga cagctgcttg tggggacatt ttacacggac ttcccgtgtc     3360

cgcccgactt ggtcgggagg tcctccttgg cccagctgat ggctatacct ccaaggggtg     3420

gagtcttctc gctcccatca ctgcttatgc ccagcaaaca cgaggcctcc tgggcgccat     3480

agtggtgagt atgacggggc gtgacaggac agaacaggcc ggggaagtcc aaatcctgtc     3540

cacagtctct cagtccttcc tcggaacaac catctcgggg gttttgtgga ctgtttacca     3600

cggagctggc aacaagactc tagccggctt acggggtccg gtcacgcaga tgtactcgag     3660

tgctgagggg gacttggtag gctggcccag cccccctggg accaagtctt tggagccgtg     3720

caagtgtgga gccgtcgacc tatatctggt cacgcggaac gctgatgtca tcccggctcg     3780

gagacgcggg gacaagcggg gagcattgct ctccccgaga cccatttcga ccttgaaggg     3840

gtcctcgggg gggccggtgc tctgccctag gggccacgtc gttgggctct tccgagcagc     3900

tgtgtgctct cggggcgtgg ccaaatccat cgatttcatc cccgttgaga cactcgacgt     3960

tgttacaagg tctcccactt tcagtgacaa cagcacgcca ccggctgtgc cccagaccta     4020

tcaggtcggg tacttgcatg ctccaactgg cagtggaaag agcaccaagg tccctgtcgc     4080

gtatgccgcc caggggtaca aagtactagt gcttaacccc tcggtagctg ccaccctggg     4140

gtttggggcg tacctatcca aggcacatgg catcaatccc aacattagga ctggagtcag     4200

gaccgtgatg accggggagg ccatcacgta ctccacatat ggcaaatttc tcgccgatgg     4260

gggctgcgct agcggcgcct atgacatcat catatgcgat gaatgccacg ctgtggatgc     4320

tacctccatt ctcggcatcg gaacggtcct tgatcaagca gagacagccg gggtcagact     4380

aactgtgctg gctacggcca caccccccgg gtcagtgaca accccccatc ccgatataga     4440

agaggtaggc ctcgggcggg agggtgagat ccccttctat gggagggcga ttcccctatc     4500

ctgcatcaag ggagggagac acctgatttt ctgccactca aagaaaaagt gtgacgagct     4560

cgcggcggcc cttcggggca tgggcttgaa tgccgtggca tactatagag ggttggacgt     4620

ctccataata ccagctcagg gagatgtggt ggtcgtcgcc accgacgccc tcatgacggg     4680

gtacactgga gactttgact ccgtgatcga ctgcaatgta gcggtcaccc aagctgtcga     4740

cttcagcctg gaccccacct tcactataac cacacagact gtcccacaag acgctgtctc     4800

acgcagtcag cgccgcgggc gcacaggtag aggaagacag ggcacttata ggtatgtttc     4860

cactggtgaa cgagcctcag gaatgtttga cagtgtagtg ctttgtgagt gctacgacgc     4920

aggggctgcg tggtacgatc tcacaccagc ggagaccacc gtcaggctta gagcgtattt     4980

caacacgccc ggcctacccg tgtgtcaaga ccatcttgaa ttttgggagg cagttttcac     5040

cggcctcaca cacatagacg cccacttcct ctcccaaaca aagcaagcgg gggagaactt     5100

cgcgtaccta gtagcctacc aagctacggt gtgcgccaga gccaaggccc ctcccccgtc     5160

ctgggacgcc atgtggaagt gcctggcccg actcaagcct acgcttgcgg gccccacacc     5220

tctcctgtac cgtttgggcc ctattaccaa tgaggtcacc ctcacacacc ctgggacgaa     5280

gtacatcgcc acatgcatgc aagctgacct tgaggtcatg accagcacgt gggtcctagc     5340

tggaggagtc ctggcagccg tcgccgcata ttgcctggcg actggatgcg tttccatcat     5400

cggccgcttg cacgtcaacc agcgagtcgt cgttgcgccg gataaggagg tcctgtatga     5460

ggcttttgat gagatggagg aatgcgcctc tagggcggct ctcatcgaag aggggcagcg     5520

gatagccgag atgttgaagt ccaagatcca aggcttgctg cagcaggcct ctaagcaggc     5580

ccaggacata caacccgcta tgcaggcttc atggcccaaa gtggaacaat tttgggccag     5640

acacatgtgg aacttcatta gcggcatcca atacctcgca ggattgtcaa cactgccagg     5700

gaaccccgcg gtggcttcca tgatggcatt cagtgccgcc ctcaccagtc cgttgtcgac     5760

cagtaccacc atccttctca acatcatggg aggctggtta gcgtcccaga tcgcaccacc     5820

cgcgggggcc accggctttg tcgtcagtgg cctggtgggg gctgccgtgg gcagcatagg     5880

cctgggtaag gtgctggtgg acatcctggc aggatatggt gcgggcattt cgggggccct     5940

cgtcgcattc aagatcatgt ctggcgagaa gccctctatg gaagatgtca tcaatctact     6000

gcctgggatc ctgtctccgg gagccctggt ggtgggggtc atctgcgcgg ccattctgcg     6060

ccgccacgtg ggaccggggg agggcgcggt ccaatggatg aacaggctta ttgcctttgc     6120

ttccagagga aaccacgtcg cccctactca ctacgtgacg gagtcggatg cgtcgcagcg     6180

tgtgacccaa ctacttggct ctcttactat aaccagccta ctcagaagac tccacaattg     6240

gataactgag gactgcccca tcccatgcgg cggctcgtgg ctccgcgatg tgtgggactg     6300

ggtttgcacc atcctaacag actttaaaaa ttggctgacc tccaaattat tcccaaagat     6360

gcccggcctc ccctttgtct cctgtcaaaa ggggtacaag ggcgtgtggg ccggcactgg     6420

catcatgacc acacggtgtc cttgcggcgc caatatctct ggcaatgtcc gcttgggctc     6480

catgagaatc acggggccta agacctgcat gaatatctgg caggggacct ttcctatcaa     6540

ttgttacacg gagggccagt gcgtgccgaa acccgcgcca aactttaagg tcgccatctg     6600

gagggtggcg gcctcagagt acgcggaggt gacgcagcac gggtcatacc actacataac     6660

aggactcacc actgataact tgaaagtccc ctgccaacta ccctctcccg agttcttttc     6720

ctgggtggac ggagtgcaga tccataggtt tgcccccaca ccgaagccgt ttttccggga     6780

tgaggtctcg ttctgcgttg ggcttaattc atttgtcgtc gggtcccagc ttccttgcga     6840

ccctgaaccc gacacagacg tattgatgtc catgctaaca gatccatctc atatcacggc     6900

ggagactgca gcgcggcgtt tagcgcgggg gtcaccccca tccgaggcaa gctcctcggc     6960

gagccagcta tcggcaccat cgctgcgagc cacctgcacc acccacggca aagcctatga     7020

tgtggacatg gtggatgcta acctgttcat ggggggcgat gtgactcgga tagagtctgg     7080

gtccaaagtg gtcgttctgg actctctcga cccaatggtc gaagaaagga gcgaccttga     7140

gccttcgata ccatcagaat acatgctccc caagaagagg ttcccaccag ctttaccggc     7200

ctgggcacgg cctgattaca acccaccgct tgtggaatcg tggaaaaggc cagattacca     7260

accggccact gttgcgggct gtgctctccc tcctcctagg aaaaccccga cgcctccccc     7320

aaggaggcgc cggacagtgg gcctaagtga ggactccata ggagatgccc ttcaacagct     7380

ggccattaag tcctttggcc agcccccccc aagcggcgat tcaggccttt ccacgggggc     7440

gggcgctgcc gattccggca gtcagacgcc tcctgatgag ttggcccttt cggagacagg     7500

ttccatctct tccatgcccc ccctcgaggg ggagcttgga gatccagacc tggagcctga     7560

gcaggtagag ccccaacccc ccccccaggg gggggtggca gctcccggct cggactcggg     7620

gtcctggtct acttgctccg aggaggacga ctccgtcgtg tgctgctcca tgtcatactc     7680

ctggaccggg gctctaataa ctccttgtag tcccgaagag gagaagttac cgattaaccc     7740

cttgagcaac tccctgttgc gatatcacaa caaggtgtac tgtaccacaa caaagagcgc     7800

ctcactaagg gctaaaaagg taacttttga taggatgcaa gtgctcgact cctactacga     7860

ctcagtctta aaggacatta agctagcggc ctccaaggtc accgcaaggc tcctcaccat     7920

ggaggaggct tgccagttaa ccccacccca ttctgcaaga tctaaatatg ggtttggggc     7980

taaggaggtc cgcagcttgt ccgggagggc cgttaaccac atcaagtccg tgtggaagga     8040

cctcctggag gactcagaaa caccaattcc cacaaccatt atggccaaaa atgaggtgtt     8100

ctgcgtggac cccaccaagg ggggcaagaa agcagctcgc cttatcgttt accctgacct     8160

cggcgtcagg gtctgcgaga agatggccct ttatgacatt acacaaaaac ttcctcaggc     8220

ggtgatgggg gcttcttatg gattccagta ttcccccgct cagcgggtag agtttctctt     8280

gaaagcatgg gcggaaaaga aggaccctat gggtttttcg tatgataccc gatgctttga     8340

ctcaaccgtc actgagagag acatcaggac tgaggagtcc atatatcggg cctgctcctt     8400

gcccgaggag gcccacactg ccatacactc gctaactgag agactttacg tgggagggcc     8460

tatgttcaac agcaagggcc aaacctgcgg gtacaggcgt tgccgcgcca gcggggtgct     8520

caccactagc atggggaaca ccatcacatg ctacgtgaaa gccttagcgg cttgtaaagc     8580

tgcagggata atcgcgccca caatgctggt atgcggcgat gacttggttg tcatctcaga     8640

aagccagggg accgaggagg acgagcggaa cctgagagcc ttcacggagg ctatgaccag     8700

gtattctgcc cctcctggtg acccccccag accggagtat gatctggagc tgataacatc     8760

ttgctcctca aatgtgtctg tggcgttggg cccgcggggc cgccgcagat actacctgac     8820

cagagaccca accactccac tcgcccgggc tgcctgggaa acagttagac actcccctat     8880

caattcatgg ctgggaaaca tcatccagta tgctccaacc atatgggttc gcatggtcct     8940

aatgacacac ttcttctcca ttctcatggt ccaagacacc ctggaccaga acctcaactt     9000

tgagatgtat ggatcagtat actccgtgaa tcctttggac cttccagcca taattgagag     9060

gttacacggg cttgacgcct tttctatgca cacatactct caccacgaac tgacgcgggt     9120

ggcttcagcc ctcagaaaac ttggggcgcc acccctcagg gtgtggaaga gtcgggctcg     9180

cgcagtcagg gcgtccctca tctcccgtgg agggaaagcg gccgtttgcg gccgatatct     9240

cttcaattgg gcggtgaaga ccaagctcaa actcactcca ttgccggagg cgcgcctact     9300

ggacttatcc agttggttca ccgtcggcgc cggcgggggc gacatttttc acagcgtgtc     9360

gcgcgcccga ccccgctcat tactcttcgg cctactccta cttttcgtag gggtaggcct     9420

cttcctactc cccgctcggt agagcggcac acactaggta cactccatag ctaactgttc     9480

cttttttttt tttttttttt tttttttttt tttttttttt ttttcttttt tttttttttc     9540

cctctttctt cccttctcat cttattctac tttctttctt ggtggctcca tcttagccct     9600

agtcacggct agctgtgaaa ggtccgtgag ccgcatgact gcagagagtg ccgtaactgg     9660

tctctctgca gatcatgt                                                   9678


<210>  3
<211>  9678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  3
acctgcccct aataggggcg acactccgcc atgaatcact cccctgtgag gaactactgt       60

cttcacgcag aaagcgccta gccatggcgt tagtatgagt gtcgtacagc ctccaggccc      120

ccccctcccg ggagagccat agtggtctgc ggaaccggtg agtacaccgg aattgccggg      180

aagactgggt cctttcttgg ataaacccac tctatgcccg gccatttggg cgtgcccccg      240

caagactgct agccgagtag cgttgggttg cgaaaggcct tgtggtactg cctgataggg      300

cgcttgcgag tgccccggga ggtctcgtag accgtgcacc atgagcacaa atcctaaacc      360

tcaaagaaaa accaaaagaa acaccaaccg tcgcccacaa gacgttaagt ttccgggcgg      420

cggccagatc gttggcggag tatacttgtt gccgcgcagg ggccccaggt tgggtgtgcg      480

cgcgacaagg aagacttcgg agcggtccca gccacgtgga aggcgccagc ccatccctaa      540

agatcggcgc tccactggca aatcctgggg aaaaccagga tacccctggc ccctatacgg      600

gaatgaggga ctcggctggg caggatggct cctgtccccc cgaggttccc gtccctcttg      660

gggccccaat gacccccggc ataggtcgcg caacgtgggt aaggtcatcg ataccctaac      720

gtgcggcttt gccgacctca tggggtacat ccctgtcgtg ggcgccccgc tcggcggcgt      780

cgccagagct ctcgcgcatg gcgtgagagt cctggaggac ggggttaatt ttgcaacagg      840

gaacttaccc ggttgctcct tttctatctt cttgctggcc ctgctgtcct gcatcaccac      900

cccggtctcc gctgccgaag tgaagaacat cagtaccggc tacatggtga ctaacgactg      960

caccaatgac agcattacct ggcagctcca ggctgctgtc ctccacgtcc ccgggtgcgt     1020

cccgtgcgag aaagtgggga atgcatctca gtgctggata ccggtctcac cgaatgtggc     1080

cgtgcagcgg cccggcgccc tcacgcaggg cttgcggacg cacatcgaca tggttgtgat     1140

gtccgccacg ctctgctctg ccctctacgt gggggacctc tgcggtgggg tgatgctcgc     1200

agcccaaatg ttcattgtct cgccgcagca ccactggttt gtccaagact gcaattgctc     1260

catctaccct ggtaccatca ctggacaccg catggcatgg gacatgatga tgaactggtc     1320

gcccacggct accatgatct tggcgtacgc gatgcgtgtc cccgaggtca ttatagacat     1380

cattagcggg gctcattggg gcgtcatgtt cggcttggcc tacttctcta tgcagggagc     1440

gtgggcgaaa gtcgttgtca tccttctgtt ggccgccggg gtggacgcgc gcacccatac     1500

tgttgggggt tctgccgcgc agaccaccgg gcgcctcacc agcttatttg acatgggccc     1560

caggcagaaa atccagctcg ttaacaccaa tggcagctgg cacatcaacc gcaccgccct     1620

gaactgcaat gactccttgc acaccggctt tatcgcgtct ctgttctaca cccacagctt     1680

caactcgtca ggatgtcccg aacgcatgtc cgcctgccgc agtatcgagg ccttccgggt     1740

gggatggggc gccttgcaat atgaggataa tgtcaccaat ccagaggata tgagacccta     1800

ttgctggcac tacccaccaa ggcagtgtgg cgtggtctcc gcgaagactg tgtgtggccc     1860

agtgtactgt ttcaccccca gcccagtggt agtgggcacg accgacaggc ttggagcgcc     1920

cacttacacg tggggggaga atgagacaga tgtcttccta ttgaacagca ctcgaccacc     1980

gctggggtca tggttcggct gcacgtggat gaactcttct ggctacacca agacttgcgg     2040

cgcaccaccc tgccgtacta gagctgactt caacgccagc acggacctgt tgtgccccac     2100

ggactgtttt aggaagcatc ctgataccac ttacctcaaa tgcggctctg ggccctggct     2160

cacgccaagg tgcctgatcg actaccccta caggctctgg cattacccct gcacagttaa     2220

ctataccatc ttcaaaataa ggatgtatgt gggaggggtt gagcacaggc tcacggctgc     2280

atgcaatttc actcgtgggg atcgttgcaa cttggaggac agagacagaa gtcaactgtc     2340

tcctttgttg cactccacca cggaatgggc cattttacct tgctcttact cggacctgcc     2400

cgccttgtcg actggtcttc tccacctcca ccaaaacatc gtggacgtac aattcatgta     2460

tggcctatca cctgccctca caaaatacat cgtccgatgg gagtgggtaa tactcttatt     2520

cctgctctta gcggacgcca gggtttgcgc ctgcttatgg atgctcatct tgttgggcca     2580

ggccgaagca gcactagaga agctggtcat cttgcacgct gcgagcgcag ctagctgcaa     2640

tggcttccta tattttgtca tctttttcgt ggctgcttgg tacatcaagg gtcgggtagt     2700

ccccttagct acctattccc tcactggcct gtggtccttt agcctactgc tcctagcatt     2760

gccccaacag gcttatgctt atgacgcatc tgtgcatggc cagataggag cggctctgct     2820

ggtaatgatc actctcttta ctctcacccc cgggtataag acccttctca gccggttttt     2880

gtggtggttg tgctatcttc tgaccctggg ggaagctatg gtccaggagt gggcaccacc     2940

tatgcaggtg cgcggtggcc gtgatggcat catatgggcc gtcgccatat tctacccagg     3000

tgtggtgttt gacataacca agtggctctt ggcggtgctt gggcctgctt acctcctaaa     3060

aggtgctttg acgcgcgtgc cgtacttcgt cagggctcac gctctactga ggatgtgcac     3120

catggcaagg catctcgcgg ggggcaggta cgtccagatg gcgctactag cccttggcag     3180

gtggactggc acttacatct atgaccacct cacccctatg tcggattggg ctgctagtgg     3240

cctgcgggac ctggcggtcg ccgttgagcc tatcatcttc agtccgatgg agaagaaagt     3300

cattgtctgg ggagcggaga cagctgcttg tggggacatt ttacacggac ttcccgtgtc     3360

cgcccgactt ggtcgggagg tcctccttgg cccagctgat ggctatacct ccaaggggtg     3420

gagtcttctc gctcccatca ctgcttatgc ccagcaaaca cgaggcctcc tgggcgccat     3480

agtggtgagt atgacggggc gtgacaggac agaacaggcc ggggaagtcc aaatcctgtc     3540

cacagtctct cagtccttcc tcggaacaac catctcgggg gttttgtgga ctgtttacca     3600

cggagctggc aacaagactc tagccggctt acggggtccg gtcacgcaga tgtactcgag     3660

tgctgagggg gacttggtag gctggcccag cccccctggg accaagtctt tggagccgtg     3720

caagtgtgga gccgtcgacc tatatctggt cacgcggaac gctgatgtca tcccggctcg     3780

gagacgcggg gacaagcggg gagcattgct ctccccgaga cccatttcga ccttgaaggg     3840

gtcctcgggg gggccggtgc tctgccctag gggccacgtc gttgggctct tccgagcagc     3900

tgtgtgctct cggggcgtgg ccaaatccat cgatttcatc cccgttgaga cactcgacgt     3960

tgttacaagg tctcccactt tcagtgacaa cagcacgcca ccggctgtgc cccagaccta     4020

tcaggtcggg tacttgcatg ctccaactgg cagtggaaag agcaccaagg tccctgtcgc     4080

gtatgccgcc caggggtaca aagtactagt gcttaacccc tcggtagctg ccaccctggg     4140

gtttggggcg tacctatcca aggcacatgg catcaatccc aacattagga ctggagtcag     4200

gaccgtgatg accggggagg ccatcacgta ctccacatat ggcaaatttc tcgccgatgg     4260

gggctgcgct agcggcgcct atgacatcat catatgcgat gaatgccacg ctgtggatgc     4320

tacctccatt ctcggcatcg gaacggtcct tgatcaagca gagacagccg gggtcagact     4380

aactgtgctg gctacggcca caccccccgg gtcagtgaca accccccatc ccgatataga     4440

agaggtaggc ctcgggcggg agggtgagat ccccttctat gggagggcga ttcccctatc     4500

ctgcatcaag ggagggagac acctgatttt ctgccactca aagaaaaagt gtgacgagct     4560

cgcggcggcc cttcggggca tgggcttgaa tgccgtggca tactatagag ggttggacgt     4620

ctccataata ccagctcagg gagatgtggt ggtcgtcgcc accgacgccc tcatgacggg     4680

gtacactgga gactttgact ccgtgatcga ctgcaatgta gcggtcaccc aagctgtcga     4740

cttcagcctg gaccccacct tcactataac cacacagact gtcccacaag acgctgtctc     4800

acgcagtcag cgccgcgggc gcacaggtag aggaagacag ggcacttata ggtatgtttc     4860

cactggtgaa cgagcctcag gaatgtttga cagtgtagtg ctttgtgagt gctacgacgc     4920

aggggctgcg tggtacgatc tcacaccagc ggagaccacc gtcaggctta gagcgtattt     4980

caacacgccc ggcctacccg tgtgtcaaga ccatcttgaa ttttgggagg cagttttcac     5040

cggcctcaca cacatagacg cccacttcct ctcccaaaca aagcaagcgg gggagaactt     5100

cgcgtaccta gtagcctacc aagctacggt gtgcgccaga gccaaggccc ctcccccgtc     5160

ctgggacgcc atgtggaagt gcctggcccg actcaagcct acgcttgcgg gccccacacc     5220

tctcctgtac cgtttgggcc ctattaccaa tgaggtcacc ctcacacacc ctgggacgaa     5280

gtacatcgcc acatgcatgc aagctgacct tgaggtcatg accagcacgt gggtcctagc     5340

tggaggagtc ctggcagccg tcgccgcata ttgcctggcg actggatgcg tttccatcat     5400

cggccgcttg cacgtcaacc agcgagtcgt cgttgcgccg gataaggagg tcctgtatga     5460

ggcttttgat gagatggagg aatgcgcctc tagggcggct ctcatcgaag aggggcagcg     5520

gatagccgag atgttgaagt ccaagatcca aggcttgctg cagcaggcct ctaagcaggc     5580

ccaggacata caacccgcta tgcaggcttc atggcccaaa gtggaacaat tttgggccag     5640

acacatgtgg aacttcatta gcggcatcca atacctcgca ggattgtcaa cactgccagg     5700

gaaccccgcg gtggcttcca tgatggcatt cagtgccgcc ctcaccagtc cgttgtcgac     5760

cagtaccacc atccttctca acatcatggg aggctggtta gcgtcccaga tcgcaccacc     5820

cgcgggggcc accggctttg tcgtcagtgg cctggtgggg gctgccgtgg gcagcatagg     5880

cctgggtaag gtgctggtgg acatcctggc aggatatggt gcgggcattt cgggggccct     5940

cgtcgcattc aagatcatgt ctggcgagaa gccctctatg gaagatgtca tcaatctact     6000

gcctgggatc ctgtctccgg gagccctggt ggtgggggtc atctgcgcgg ccattctgcg     6060

ccgccacgtg ggaccggggg agggcgcggt ccaatggatg aacaggctta ttgcctttgc     6120

ttccagagga aaccacgtcg cccctactca ctacgtgacg gagtcggatg cgtcgcagcg     6180

tgtgacccaa ctacttggct ctcttactat aaccagccta ctcagaagac tccacaattg     6240

gataactgag gactgcccca tcccatgcgg cggctcgtgg ctccgcgatg tgtgggactg     6300

ggtttgcacc atcctaacag actttaaaaa ttggctgacc tccaaattat tcccaaagat     6360

gcccggcctc ccctttgtct cctgtcaaaa ggggtacaag ggcgtgtggg ccggcactgg     6420

catcatgacc acacggtgtc cttgcggcgc caatatctct ggcaatgtcc gcttgggctc     6480

catgagaatc acggggccta agacctgcat gaatatctgg caggggacct ttcctatcaa     6540

ttgttacacg gagggccagt gcgtgccgaa acccgcgcca aactttaagg tcgccatctg     6600

gagggtggcg gcctcagagt acgcggaggt gacgcagcac gggtcatacc actacataac     6660

aggactcacc actgataact tgaaagtccc ctgccaacta ccctctcccg agttcttttc     6720

ctgggtggac ggagtgcaga tccataggtt tgcccccaca ccgaagccgt ttttccggga     6780

tgaggtctcg ttctgcgttg ggcttaattc atttgtcgtc gggtcccagc ttccttgcga     6840

ccctgaaccc gacacagacg tattgatgtc catgctaaca gatccatctc atatcacggc     6900

ggagactgca gcgcggcgtt tagcgcgggg gtcaccccca tccgaggcaa gctcctcggc     6960

gagccagcta tcggcaccat cgctgcgagc cacctgcacc acccacggca aagcctatga     7020

tgtggacatg gtggatgcta acctgttcat ggggggcgat gtgactcgga tagagtctgg     7080

gtccaaagtg gtcgttctgg actctctcga cccaatggtc gaagaaagga gcgaccttga     7140

gccttcgata ccatcagaat acatgctccc caagaagagg ttcccaccag ctttaccggc     7200

ctgggcacgg cctgattaca acccaccgct tgtggaatcg tggaaaaggc cagattacca     7260

accggccact gttgcgggct gtgctctccc tcctcctagg aaaaccccga cgcctccccc     7320

aaggaggcgc cggacagtgg gcctaagtga ggactccata ggagatgccc ttcaacagct     7380

ggccattaag tcctttggcc agcccccccc aagcggcgat tcaggccttt ccacgggggc     7440

gggcgctgcc gattccggca gtcagacgcc tcctgatgag ttggcccttt cggagacagg     7500

ttccatctct tccatgcccc ccctcgaggg ggagcttgga gatccagacc tggagcctga     7560

gcaggtagag ccccaacccc ccccccaggg gggggtggca gctcccggct cggactcggg     7620

gtcctggtct acttgctccg aggaggacga ctccgtcgtg tgctgctcca tgtcatactc     7680

ctggaccggg gctctaataa ctccttgtag tcccgaagag gagaagttac cgattaaccc     7740

cttgagcaac tccctgttgc gatatcacaa caaggtgtac tgtaccacaa caaagagcgc     7800

ctcactaagg gctaaaaagg taacttttga taggatgcaa gtgctcgact cctactacga     7860

ctcagtctta aaggacatta agctagcggc ctccaaggtc accgcaaggc tcctcaccat     7920

ggaggaggct tgccagttaa ccccacccca ttctgcaaga tctaaatatg ggtttggggc     7980

taaggaggtc cgcagcttgt ccgggagggc cgttaaccac atcaagtccg tgtggaagga     8040

cctcctggag gactcagaaa caccaattcc cacaaccatt atggccaaaa atgaggtgtt     8100

ctgcgtggac cccaccaagg ggggcaagaa agcagctcgc cttatcgttt accctgacct     8160

cggcgtcagg gtctgcgaga agatggccct ttatgacatt acacaaaaac ttcctcaggc     8220

ggtgatgggg gcttcttatg gattccagta ttcccccgct cagcgggtag agtttctctt     8280

gaaagcatgg gcggaaaaga aggaccctat gggtttttcg tatgataccc gatgctttga     8340

ctcaaccgtc actgagagag acatcaggac tgaggagtcc atatatcggg cctgctcctt     8400

gcccgaggag gcccacactg ccatacactc gctaactgag agactttacg tgggagggcc     8460

tatgttcaac agcaagggcc aaacctgcgg gtacaggcgt tgccgcgcca gcggggtgct     8520

caccactagc atggggaaca ccatcacatg ctacgtgaaa gccttagcgg cttgtaaagc     8580

tgcagggata atcgcgccca caatgctggt atgcggcgat gacttggttg tcatctcaga     8640

aagccagggg accgaggagg acgagcggaa cctgagagcc ttcacggagg ctatgaccag     8700

gtattctgcc cctcctggtg acccccccag accggagtat gatctggagc tgataacatc     8760

ttgctcctca aatgtgtctg tggcgctggg cccacaaggc cgccgcagat actacctgac     8820

cagagaccct accactccaa tcgcccgggc tgcctgggaa acagttagac actcccctgt     8880

caattcatgg ctgggaaaca tcatccagta cgccccgacc atatgggctc gcatggtcct     8940

gatgacacac ttcttctcca ttctcatggt ccaagacacc ctggaccaga acctcaactt     9000

tgagatgtat ggatcagtat actccgtgaa tcctttggac cttccagcca taattgagag     9060

gttacacggg cttgacgcct tttctatgca cacatactct caccacgaac tgacgcgggt     9120

ggcttcagcc ctcagaaaac ttggggcgcc acccctcagg gtgtggaaga gtcgggctcg     9180

cgcagtcagg gcgtccctca tctcccgtgg agggaaagcg gccgtttgcg gccgatatct     9240

cttcaattgg gcggtgaaga ccaagctcaa actcactcca ttgccggagg cgcgcctact     9300

ggacttatcc agttggttca ccgtcggcgc cggcgggggc gacatttttc acagcgtgtc     9360

gcgcgcccga ccccgctcat tactcttcgg cctactccta cttttcgtag gggtaggcct     9420

cttcctactc cccgctcggt agagcggcac acactaggta cactccatag ctaactgttc     9480

cttttttttt tttttttttt tttttttttt tttttttttt ttttcttttt tttttttttc     9540

cctctttctt cccttctcat cttattctac tttctttctt ggtggctcca tcttagccct     9600

agtcacggct agctgtgaaa ggtccgtgag ccgcatgact gcagagagtg ccgtaactgg     9660

tctctctgca gatcatgt                                                   9678


<210>  4
<211>  9678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  4
acctgcccct aataggggcg acactccgcc atgaatcact cccctgtgag gaactactgt       60

cttcacgcag aaagcgccta gccatggcgt tagtatgagt gtcgtacagc ctccaggccc      120

ccccctcccg ggagagccat agtggtctgc ggaaccggtg agtacaccgg aattgccggg      180

aagactgggt cctttcttgg ataaacccac tctatgcccg gccatttggg cgtgcccccg      240

caagactgct agccgagtag cgttgggttg cgaaaggcct tgtggtactg cctgataggg      300

cgcttgcgag tgccccggga ggtctcgtag accgtgcacc atgagcacaa atcctaaacc      360

tcaaagaaaa accaaaagaa acaccaaccg tcgcccacaa gacgttaagt ttccgggcgg      420

cggccagatc gttggcggag tatacttgtt gccgcgcagg ggccccaggt tgggtgtgcg      480

cgcgacaagg aagacttcgg agcggtccca gccacgtgga aggcgccagc ccatccctaa      540

agatcggcgc tccactggca aatcctgggg aaaaccagga tacccctggc ccctatacgg      600

gaatgaggga ctcggctggg caggatggct cctgtccccc cgaggttccc gtccctcttg      660

gggccccaat gacccccggc ataggtcgcg caacgtgggt aaggtcatcg ataccctaac      720

gtgcggcttt gccgacctca tggggtacat ccctgtcgtg ggcgccccgc tcggcggcgt      780

cgccagagct ctcgcgcatg gcgtgagagt cctggaggac ggggttaatt ttgcaacagg      840

gaacttaccc ggttgctcct tttctatctt cttgctggcc ctgctgtcct gcatcaccac      900

cccggtctcc gctgccgaag tgaagaacat cagtaccggc tacatggtga ctaacgactg      960

caccaatgac agcattacct ggcagctcca ggctgctgtc ctccacgtcc ccgggtgcgt     1020

cccgtgcgag aaagtgggga atgcatctca gtgctggata ccggtctcac cgaatgtggc     1080

cgtgcagcgg cccggcgccc tcacgcaggg cttgcggacg cacatcgaca tggttgtgat     1140

gtccgccacg ctctgctctg ccctctacgt gggggacctc tgcggtgggg tgatgctcgc     1200

agcccaaatg ttcattgtct cgccgcagca ccactggttt gtccaagact gcaattgctc     1260

catctaccct ggtaccatca ctggacaccg catggcatgg gacatgatga tgaactggtc     1320

gcccacggct accatgatct tggcgtacgc gatgcgtgtc cccgaggtca ttatagacat     1380

cattagcggg gctcattggg gcgtcatgtt cggcttggcc tacttctcta tgcagggagc     1440

gtgggcgaaa gtcgttgtca tccttctgtt ggccgccggg gtggacgcgc gcacccatac     1500

tgttgggggt tctgccgcgc agaccaccgg gcgcctcacc agcttatttg acatgggccc     1560

caggcagaaa atccagctcg ttaacaccaa tggcagctgg cacatcaacc gcaccgccct     1620

gaactgcaat gactccttgc acaccggctt tatcgcgtct ctgttctaca cccacagctt     1680

caactcgtca ggatgtcccg aacgcatgtc cgcctgccgc agtatcgagg ccttccgggt     1740

gggatggggc gccttgcaat atgaggataa tgtcaccaat ccagaggata tgagacccta     1800

ttgctggcac tacccaccaa ggcagtgtgg cgtggtctcc gcgaagactg tgtgtggccc     1860

agtgtactgt ttcaccccca gcccagtggt agtgggcacg accgacaggc ttggagcgcc     1920

cacttacacg tggggggaga atgagacaga tgtcttccta ttgaacagca ctcgaccacc     1980

gctggggtca tggttcggct gcacgtggat gaactcttct ggctacacca agacttgcgg     2040

cgcaccaccc tgccgtacta gagctgactt caacgccagc acggacctgt tgtgccccac     2100

ggactgtttt aggaagcatc ctgataccac ttacctcaaa tgcggctctg ggccctggct     2160

cacgccaagg tgcctgatcg actaccccta caggctctgg cattacccct gcacagttaa     2220

ctataccatc ttcaaaataa ggatgtatgt gggaggggtt gagcacaggc tcacggctgc     2280

atgcaatttc actcgtgggg atcgttgcaa cttggaggac agagacagaa gtcaactgtc     2340

tcctttgttg cactccacca cggaatgggc cattttacct tgctcttact cggacctgcc     2400

cgccttgtcg actggtcttc tccacctcca ccaaaacatc gtggacgtac aattcatgta     2460

tggcctatca cctgccctca caaaatacat cgtccgatgg gagtgggtaa tactcttatt     2520

cctgctctta gcggacgcca gggtttgcgc ctgcttatgg atgctcatct tgttgggcca     2580

ggccgaagca gcactagaga agctggtcat cttgcacgct gcgagcgcag ctagctgcaa     2640

tggcttccta tattttgtca tctttttcgt ggctgcttgg tacatcaagg gtcgggtagt     2700

ccccttagct acctattccc tcactggcct gtggtccttt agcctactgc tcctagcatt     2760

gccccaacag gcttatgctt atgacgcatc tgtgcatggc cagataggag cggctctgct     2820

ggtaatgatc actctcttta ctctcacccc cgggtataag acccttctca gccggttttt     2880

gtggtggttg tgctatcttc tgaccctggg ggaagctatg gtccaggagt gggcaccacc     2940

tatgcaggtg cgcggtggcc gtgatggcat catatgggcc gtcgccatat tctacccagg     3000

tgtggtgttt gacataacca agtggctctt ggcggtgctt gggcctgctt acctcctaaa     3060

aggtgctttg acgcgcgtgc cgtacttcgt cagggctcac gctctactga ggatgtgcac     3120

catggcaagg catctcgcgg ggggcaggta cgtccagatg gcgctactag cccttggcag     3180

gtggactggc acttacatct atgaccacct cacccctatg tcggattggg ctgctagtgg     3240

cctgcgggac ctggcggtcg ccgttgagcc tatcatcttc agtccgatgg agaagaaagt     3300

cattgtctgg ggagcggaga cagctgcttg tggggacatt ttacacggac ttcccgtgtc     3360

cgcccgactt ggtcgggagg tcctccttgg cccagctgat ggctatacct ccaaggggtg     3420

gagtcttctc gctcccatca ctgcttatgc ccagcaaaca cgaggcctcc tgggcgccat     3480

agtggtgagt atgacggggc gtgacaggac agaacaggcc ggggaagtcc aaatcctgtc     3540

cacagtctct cagtccttcc tcggaacaac catctcgggg gttttgtgga ctgtttacca     3600

cggagctggc aacaagactc tagccggctt acggggtccg gtcacgcaga tgtactcgag     3660

tgctgagggg gacttggtag gctggcccag cccccctggg accaagtctt tggagccgtg     3720

caagtgtgga gccgtcgacc tatatctggt cacgcggaac gctgatgtca tcccggctcg     3780

gagacgcggg gacaagcggg gagcattgct ctccccgaga cccatttcga ccttgaaggg     3840

gtcctcgggg gggccggtgc tctgccctag gggccacgtc gttgggctct tccgagcagc     3900

tgtgtgctct cggggcgtgg ccaaatccat cgatttcatc cccgttgaga cactcgacgt     3960

tgttacaagg tctcccactt tcagtgacaa cagcacgcca ccggctgtgc cccagaccta     4020

tcaggtcggg tacttgcatg ctccaactgg cagtggaaag agcaccaagg tccctgtcgc     4080

gtatgccgcc caggggtaca aagtactagt gcttaacccc tcggtagctg ccaccctggg     4140

gtttggggcg tacctatcca aggcacatgg catcaatccc aacattagga ctggagtcag     4200

gaccgtgatg accggggagg ccatcacgta ctccacatat ggcaaatttc tcgccgatgg     4260

gggctgcgct agcggcgcct atgacatcat catatgcgat gaatgccacg ctgtggatgc     4320

tacctccatt ctcggcatcg gaacggtcct tgatcaagca gagacagccg gggtcagact     4380

aactgtgctg gctacggcca caccccccgg gtcagtgaca accccccatc ccgatataga     4440

agaggtaggc ctcgggcggg agggtgagat ccccttctat gggagggcga ttcccctatc     4500

ctgcatcaag ggagggagac acctgatttt ctgccactca aagaaaaagt gtgacgagct     4560

cgcggcggcc cttcggggca tgggcttgaa tgccgtggca tactatagag ggttggacgt     4620

ctccataata ccagctcagg gagatgtggt ggtcgtcgcc accgacgccc tcatgacggg     4680

gtacactgga gactttgact ccgtgatcga ctgcaatgta gcggtcaccc aagctgtcga     4740

cttcagcctg gaccccacct tcactataac cacacagact gtcccacaag acgctgtctc     4800

acgcagtcag cgccgcgggc gcacaggtag aggaagacag ggcacttata ggtatgtttc     4860

cactggtgaa cgagcctcag gaatgtttga cagtgtagtg ctttgtgagt gctacgacgc     4920

aggggctgcg tggtacgatc tcacaccagc ggagaccacc gtcaggctta gagcgtattt     4980

caacacgccc ggcctacccg tgtgtcaaga ccatcttgaa ttttgggagg cagttttcac     5040

cggcctcaca cacatagacg cccacttcct ctcccaaaca aagcaagcgg gggagaactt     5100

cgcgtaccta gtagcctacc aagctacggt gtgcgccaga gccaaggccc ctcccccgtc     5160

ctgggacgcc atgtggaagt gcctggcccg actcaagcct acgcttgcgg gccccacacc     5220

tctcctgtac cgtttgggcc ctattaccaa tgaggtcacc ctcacacacc ctgggacgaa     5280

gtacatcgcc acatgcatgc aagctgacct tgaggtcatg accagcacgt gggtcctagc     5340

tggaggagtc ctggcagccg tcgccgcata ttgcctggcg actggatgcg tttccatcat     5400

cggccgcttg cacgtcaacc agcgagtcgt cgttgcgccg gataaggagg tcctgtatga     5460

ggcttttgat gagatggagg aatgcgcctc tagggcggct ctcatcgaag aggggcagcg     5520

gatagccgag atgttgaagt ccaagatcca aggcttgctg cagcaggcct ctaagcaggc     5580

ccaggacata caacccgcta tgcaggcttc atggcccaaa gtggaacaat tttgggccag     5640

acacatgtgg aacttcatta gcggcatcca atacctcgca ggattgtcaa cactgccagg     5700

gaaccccgcg gtggcttcca tgatggcatt cagtgccgcc ctcaccagtc cgttgtcgac     5760

cagtaccacc atccttctca acatcatggg aggctggtta gcgtcccaga tcgcaccacc     5820

cgcgggggcc accggctttg tcgtcagtgg cctggtgggg gctgccgtgg gcagcatagg     5880

cctgggtaag gtgctggtgg acatcctggc aggatatggt gcgggcattt cgggggccct     5940

cgtcgcattc aagatcatgt ctggcgagaa gccctctatg gaagatgtca tcaatctact     6000

gcctgggatc ctgtctccgg gagccctggt ggtgggggtc atctgcgcgg ccattctgcg     6060

ccgccacgtg ggaccggggg agggcgcggt ccaatggatg aacaggctta ttgcctttgc     6120

ttccagagga aaccacgtcg cccctactca ctacgtgacg gagtcggatg cgtcgcagcg     6180

tgtgacccaa ctacttggct ctcttactat aaccagccta ctcagaagac tccacaattg     6240

gataactgag gactgcccca tcccatgcgg cggctcgtgg ctccgcgatg tgtgggactg     6300

ggtttgcacc atcctaacag actttaaaaa ttggctgacc tccaaattat tcccaaagat     6360

gcccggcctc ccctttgtct cctgtcaaaa ggggtacaag ggcgtgtggg ccggcactgg     6420

catcatgacc acacggtgtc cttgcggcgc caatatctct ggcaatgtcc gcttgggctc     6480

catgagaatc acggggccta agacctgcat gaatatctgg caggggacct ttcctatcaa     6540

ttgttacacg gagggccagt gcgtgccgaa acccgcgcca aactttaagg tcgccatctg     6600

gagggtggcg gcctcagagt acgcggaggt gacgcagcac gggtcatacc actacataac     6660

aggactcacc actgataact tgaaagtccc ctgccaacta ccctctcccg agttcttttc     6720

ctgggtggac ggagtgcaga tccataggtt tgcccccaca ccgaagccgt ttttccggga     6780

tgaggtctcg ttctgcgttg ggcttaattc atttgtcgtc gggtcccagc ttccttgcga     6840

ccctgaaccc gacacagacg tattgatgtc catgctaaca gatccatctc atatcacggc     6900

ggagactgca gcgcggcgtt tagcgcgggg gtcaccccca tccgaggcaa gctcctcggc     6960

gagccagcta tcggcaccat cgctgcgagc cacctgcacc acccacggca aagcctatga     7020

tgtggacatg gtggatgcta acctgttcat ggggggcgat gtgactcgga tagagtctgg     7080

gtccaaagtg gtcgttctgg actctctcga cccaatggtc gaagaaagga gcgaccttga     7140

gccttcgata ccatcagaat acatgctccc caagaagagg ttcccaccag ctttaccggc     7200

ctgggcacgg cctgattaca acccaccgct tgtggaatcg tggaaaaggc cagattacca     7260

accggccact gttgcgggct gtgctctccc tcctcctagg aaaaccccga cgcctccccc     7320

aaggaggcgc cggacagtgg gcctaagtga ggactccata ggagatgccc ttcaacagct     7380

ggccattaag tcctttggcc agcccccccc aagcggcgat tcaggccttt ccacgggggc     7440

gggcgctgcc gattccggca gtcagacgcc tcctgatgag ttggcccttt cggagacagg     7500

ttccatctct tccatgcccc ccctcgaggg ggagcttgga gatccagacc tggagcctga     7560

gcaggtagag ccccaacccc ccccccaggg gggggtggca gctcccggct cggactcggg     7620

gtcctggtct acttgctccg aggaggacga ctccgtcgtg tgctgctcca tgtcatactc     7680

ctggaccggg gctctaataa ctccttgtag tcccgaagag gagaagttac cgattaaccc     7740

cttgagcaac tccctgttgc gatatcacaa caaggtgtac tgtaccacaa caaagagcgc     7800

ctcactaagg gctaaaaagg taacttttga taggatgcaa gtgctcgact cctactacga     7860

ctcagtctta aaggacatta agctagcggc ctccaaggtc accgcaaggc tcctcaccat     7920

ggaggaggct tgccagttaa ccccacccca ttctgcaaga tctaaatatg ggtttggggc     7980

taaggaggtc cgcagcttgt ccgggagggc cgttaaccac atcaagtccg tgtggaagga     8040

cctcctggag gactcagaaa caccaattcc cacaaccatt atggccaaaa atgaggtgtt     8100

ctgcgtggac cccaccaagg ggggcaagaa agcagctcgc cttatcgttt accctgacct     8160

cggcgtcagg gtctgcgaga agatggccct ttatgacatt acacaaaaac ttcctcaggc     8220

ggtgatgggg gcttcttatg gattccagta ttcccccgct cagcgggtag agtttctctt     8280

gaaagcatgg gcggaaaaga aggaccctat gggtttttcg tatgataccc gatgctttga     8340

ctcaaccgtc actgagagag acatcaggac tgaggagtcc atatatcggg cctgctcctt     8400

gcccgaggag gcccacactg ccatacactc gctaactgag agactttacg tgggagggcc     8460

tatgttcaac agcaagggcc aaacctgcgg gtacaggcgt tgccgcgcca gcggggtgct     8520

caccactagc atggggaaca ccatcacatg ctacgtgaaa gccttagcgg cttgtaaagc     8580

tgcagggata atcgcgccca caatgctggt atgcggcgat gacttggttg tcatctcaga     8640

aagccagggg accgaggagg acgagcggaa cctgagagcc ttcacggagg ctatgaccag     8700

gtattctgcc cctcctggtg acccccccag accggagtat gatctggagc tgataacatc     8760

ttgctcctca aatgtgtctg tggcgctggg cccacaaggc cgccgcagat actacctgac     8820

cagagaccct accactccaa tcgcccgggc tgcctgggaa acagttagac actcccctgt     8880

caattcatgg ctgggaaaca tcatccagta cgccccgacc atatgggctc gcatggtcct     8940

gatgacacac ttcttctcca ttctcatggc tcaagacacg ctggaccaga acctcaactt     9000

tgagatgtac ggagcggtgt actccgtgag tcccttggac ctcccagcta taattgaaag     9060

gttacacggg cttgacgcct tttctatgca cacatactct caccacgaac tgacgcgggt     9120

ggcttcagcc ctcagaaaac ttggggcgcc acccctcagg gtgtggaaga gtcgggctcg     9180

cgcagtcagg gcgtccctca tctcccgtgg agggaaagcg gccgtttgcg gccgatatct     9240

cttcaattgg gcggtgaaga ccaagctcaa actcactcca ttgccggagg cgcgcctact     9300

ggacttatcc agttggttca ccgtcggcgc cggcgggggc gacatttttc acagcgtgtc     9360

gcgcgcccga ccccgctcat tactcttcgg cctactccta cttttcgtag gggtaggcct     9420

cttcctactc cccgctcggt agagcggcac acactaggta cactccatag ctaactgttc     9480

cttttttttt tttttttttt tttttttttt tttttttttt ttttcttttt tttttttttc     9540

cctctttctt cccttctcat cttattctac tttctttctt ggtggctcca tcttagccct     9600

agtcacggct agctgtgaaa ggtccgtgag ccgcatgact gcagagagtg ccgtaactgg     9660

tctctctgca gatcatgt                                                   9678


<210>  5
<211>  9678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  5
acccgcccct aataggggcg acactccgcc atgaatcact cccctgtgag gaactactgt       60

cttcacgcag aaagcgtcta gccatggcgt tagtatgagt gtcgtacagc ctccaggccc      120

ccccctcccg ggagagccat agtggtctgc ggaaccggtg agtacaccgg aattgccggg      180

aagactgggt cctttcttgg ataaacccac tctatgcccg gccatttggg cgtgcccccg      240

caagactgct agccgagtag cgttgggttg cgaaaggcct tgtggtactg cctgataggg      300

tgcttgcgag tgccccggga ggtctcgtag accgtgcacc atgagcacaa atcctaaacc      360

tcaaagaaaa accaaaagaa acaccaaccg tcgcccacaa gacgttaagt ttccgggcgg      420

cggccagatc gttggcggag tatacttgtt gccgcgcagg ggccccaggt tgggtgtgcg      480

cgcgacaagg aagacttcgg agcggtccca gccacgtgga aggcgccagc ccatccctaa      540

agatcggcgc tccactggca aatcctgggg aaaaccagga tacccctggc ccctatacgg      600

gaatgaggga ctcggctggg caggatggct cctgtccccc cgaggttccc gtccctcttg      660

gggccccaat gacccccggc ataggtcgcg caacgtgggt aaggtcatcg ataccctaac      720

gtgcggcttt gccgacctca tggggtacat ccctgtcgtg ggcgccccgc tcggcggcgt      780

cgccagagct ctcgcgcatg gcgtgagagt cctggaggac ggggttaatt ttgcaacagg      840

gaacttaccc ggttgctcct tttctatctt cttgctggcc ctgctgtcct gcatcaccac      900

cccggtctcc gctgccgaag tgaagaacat cagtaccggc tacatggtga ctaacgactg      960

caccaatgac agcattacct ggcagctcca ggctgctgtc ctccacgtcc ccgggtgcgt     1020

cccgtgcgag aaagtgggga atgcatctca gtgctggata ccggtctcac cgaatgtggc     1080

cgtgcagcgg cccggcgccc tcacgcaggg cttgcggacg cacatcgaca tggttgtgat     1140

gtccgccacg ctctgctctg ccctctacgt gggggacctc tgcggtgggg tgatgctcgc     1200

agcccaaatg ttcattgtct cgccgcagca ccactggttt gtccaagact gcaattgctc     1260

catctaccct ggtaccatca ctggacaccg catggcatgg gacatgatga tgaactggtc     1320

gcccacggct accatgatct tggcgtacgc gatgcgtgtc cccgaggtca ttatagacat     1380

cattagcggg gctcattggg gcgtcatgtt cggcttggcc tacttctcta tgcagggagc     1440

gtgggcgaaa gtcgttgtca tccttctgtt ggccgccggg gtggacgcgc gcacccatac     1500

tgttgggggt tctgccgcgc agaccaccgg gcgcctcacc agcttatttg acatgggccc     1560

caggcagaaa atccagctcg ttaacaccaa tggcagctgg cacatcaacc gcaccgccct     1620

gaactgcaat gactccttgc acaccggctt tatcgcgtct ctgttctaca cccacagctt     1680

caactcgtca ggatgtcccg aacgcatgtc cgcctgccgc agtatcgagg ccttccgggt     1740

gggatggggc gccttgcaat atgaggataa tgtcaccaat ccagaggata tgagacccta     1800

ttgctggcac tacccaccaa ggcagtgtgg cgtggtctcc gcgaagactg tgtgtggccc     1860

agtgtactgt ttcaccccca gcccagtggt agtgggcacg accgacaggc ttggagcgcc     1920

cacttacacg tggggggaga atgagacaga tgtcttccta ttgaacagca ctcgaccacc     1980

gctggggtca tggttcggct gcacgtggat gaactcttct ggctacacca agacttgcgg     2040

cgcaccaccc tgccgtacta gagctgactt caacgccagc acggacctgt tgtgccccac     2100

ggactgtttt aggaagcatc ctgataccac ttacctcaaa tgcggctctg ggccctggct     2160

cacgccaagg tgcctgatcg actaccccta caggctctgg cattacccct gcacagttaa     2220

ctataccatc ttcaaaataa ggatgtatgt gggaggggtt gagcacaggc tcacggctgc     2280

atgcaatttc actcgtgggg atcgttgcaa cttggaggac agagacagaa gtcaactgtc     2340

tcctttgttg cactccacca cggaatgggc cattttacct tgctcttact cggacctgcc     2400

cgccttgtcg actggtcttc tccacctcca ccaaaacatc gtggacgtac aattcatgta     2460

tggcctatca cctgccctca caaaatacat cgtccgatgg gagtgggtaa tactcttatt     2520

cctgctctta gcggacgcca gggtttgcgc ctgcttatgg atgctcatct tgttgggcca     2580

ggccgaagca gcactagaga agctggtcat cttgcacgct gcgagcgcag ctagctgcaa     2640

tggcttccta tattttgtca tctttttcgt ggctgcttgg tacatcaagg gtcgggtagt     2700

ccccttagct acctattccc tcactggcct gtggtccttt agcctactgc tcctagcatt     2760

gccccaacag gcttatgctt atgacgcatc tgtgcatggc cagataggag cggctctgct     2820

ggtaatgatc actctcttta ctctcacccc cgggtataag acccttctca gccggttttt     2880

gtggtggttg tgctatcttc tgaccctggg ggaagctatg gtccaggagt gggcaccacc     2940

tatgcaggtg cgcggtggcc gtgatggcat catatgggcc gtcgccatat tctacccagg     3000

tgtggtgttt gacataacca agtggctctt ggcggtgctt gggcctgctt acctcctaaa     3060

aggtgctttg acgcgcgtgc cgtacttcgt cagggctcac gctctactga ggatgtgcac     3120

catggcaagg catctcgcgg ggggcaggta cgtccagatg gcgctactag cccttggcag     3180

gtggactggc acttacatct atgaccacct cacccctatg tcggattggg ctgctagtgg     3240

cctgcgggac ctggcggtcg ccgttgagcc tatcatcttc agtccgatgg agaagaaagt     3300

cattgtctgg ggagcggaga cagctgcttg tggggacatt ttacacggac ttcccgtgtc     3360

cgcccgactt ggtcgggagg tcctccttgg cccagctgat ggctatacct ccaaggggtg     3420

gagtcttctc gcccccatca ctgcttacgc ccagcagaca cgtggccttt tgggcaccat     3480

agtggtgagc atgacggggc gcgacaagac agaacaggct ggggaaattc aggtcctgtc     3540

cacagtcact cagtccttcc tcggaacatc catctcgggg gttttgtgga ctgtctacca     3600

tggagctggc aacaagactc tggccggctc acggggtccg gtcacgcaga tgtactccag     3660

tgctgagggg gacttagtag ggtggcccag cccccctggg actaaatctt tggagccgtg     3720

cacgtgtgga gcggtcgacc tgtacctggt cacgcggaac gctgatgtca tcccggctcg     3780

aagacgcggg gacaaacggg gagcgctact ctccccgaga cctctttcca ccttgaaggg     3840

gtcctcagga ggcccggtgc tatgccccag gggccacgct gtcggagtct tccgggcagc     3900

tgtgtgctct cggggcgtgg ctaagtccat agatttcatc cccgttgaga cactcgacat     3960

cgtcacgcgg tcccccacct ttagtgacaa cagcacacca cctgctgtgc cccagaccta     4020

tcaggtcggg tacttgcatg ccccgactgg cagtggaaag agcaccaaag ttcctgtcgc     4080

atatgctgct caggggtata aagtgctagt gcttaatccc tcagtggctg ccaccctggg     4140

gtttggggcg tacttgtcta aggcacatgg catcaatccc aacattagga ctggagtcag     4200

gactgtgacg accggggcgc ccatcacgta ctccacatat ggcaaattcc tcgccgatgg     4260

gggctgtgcg ggcggcgcct acgacatcat catatgtgat gaatgccatg ccgtggactc     4320

taccaccatc cttggcatcg gaacagtcct tgatcaagca gagacagctg gggtcagact     4380

aactgtgctg gctacagcta cgccccctgg gtcagtgaca accccccacc ccaacataga     4440

ggaggtggcc cttgggcagg agggcgagat ccccttctat gggagggcga ttcccctgtc     4500

ttacatcaag ggaggaagac atctgatctt ctgccattca aagaaaaagt gtgacgagct     4560

cgcggcggcc cttcggggta tgggcttgaa ctcagtggca tactacagag ggttggacgt     4620

ctccgtaata ccaactcagg gagacgtagt ggtcgtcgcc accgacgccc tcatgacagg     4680

gtatactggg gactttgact ccgtgatcga ctgcaacgta gcggtcactc aagttgtaga     4740

cttcagttta gaccccacat tcaccataac cacacagatt gtccctcaag acgctgtctc     4800

acgtagccag cgccggggtc gcacgggtag gggaagactg ggcatttata ggtatgtttc     4860

cactggtgag cgagcctcag gaatgtttga cagtgtagtg ctctgtgagt gctacgacgc     4920

aggggccgca tggtatgagc tcacaccatc ggagaccacc gtcaggctca gggcgtattt     4980

caacacgccc ggtttgcctg tgtgccaaga ccatcttgag ttttgggagg cagttttcac     5040

cggcctcaca cacatagatg cccacttcct ttcccaaaca aagcaatcgg gggaaaattt     5100

cgcatactta acagcctacc aggctacagt gtgcgctagg gccaaagccc cccccccgtc     5160

ctgggacgtc atgtggaagt gtttgactcg actcaagccc acactcgtgg gccccacacc     5220

tctcctgtac cgcttgggct ctgttaccaa cgaggtcacc ctcacacatc ccgtgacgaa     5280

atacatcgcc acctgcatgc aagccgacct tgaggtcatg accagcacat gggtcttggc     5340

agggggagtc ttggcggccg tcgccgcgta ttgcctggcg accgggtgtg tttgcatcat     5400

cggccgcttg cacattaacc agcgagccgt cgttgcgccg gacaaggagg tcctctatga     5460

ggcttttgat gagatggagg aatgtgcctc tagggcggct ctcattgaag aggggcagcg     5520

gatagccgag atgctgaagt ccaagatcca aggcttattg cagcaagctt ccaaacaagc     5580

tcaagacata caacccactg tgcaggcttc atggcccaag gtagaacaat tctgggccaa     5640

acacatgtgg aacttcatta gcggcatcca atacctcgca ggactatcaa cactgccagg     5700

gaaccctgca gtagcttcca tgatggcgtt cagtgccgcc ctcaccagtc cgctgtcaac     5760

aagcaccact atccttctca acattttggg gggctggcta gcatcccaaa ttgcaccacc     5820

cgcgggggcc actggcttcg ttgtcagtgg cctagtggga gctgccgtag gcagtatagg     5880

cttaggtaag gtgctagtgg acatcctggc agggtatggt gcgggcattt cgggggctct     5940

cgtcgcattc aagatcatgt ctggcgagaa gccctccatg gaggatgtcg tcaacttgct     6000

gcctggaatt ctgtctccgg gtgccttggt agtgggagtc atctgcgcgg ccattctgcg     6060

ccgacacgtg ggaccggggg aaggcgccgt ccaatggatg aatagactca ttgcctttgc     6120

ttccagagga aatcacgtcg cccccaccca ctacgtgacg gagtcggatg cgtcgcagcg     6180

tgtgacccaa ctacttggct cccttaccat aaccagcctg ctcagaagac tccacaactg     6240

gattactgag gactgcccca tcccatgcgg cggctcgtgg ctccgcgatg tgtgggactg     6300

ggtttgcacc atcctaacag actttaaaaa ttggctgacc tccaaattat tcccaaagat     6360

gcccggcctc ccctttgtct cctgtcaaaa ggggtacaag ggcgtgtggg ccggcactgg     6420

catcatgacc acacggtgtc cttgcggcgc caatatctct ggcaatgtcc gcttgggctc     6480

catgagaatc acggggccta agacctgcat gaatatctgg caggggacct ttcctatcaa     6540

ttgttacacg gagggccagt gcgtgccgaa acccgcgcca aactttaagg tcgccatctg     6600

gagggtggcg gcctcagagt acgcggaggt gacgcagcac gggtcatacc actacataac     6660

aggactcacc actgataact tgaaagtccc ctgccaacta ccctctcccg agttcttttc     6720

ctgggtggac ggagtgcaga tccataggtt tgcccccaca ccgaagccgt ttttccggga     6780

tgaggtctcg ttctgcgttg ggcttaattc atttgtcgtc gggtcccagc ttccttgcga     6840

ccctgaaccc gacacagacg tattgatgtc catgctaaca gatccatctc atatcacggc     6900

ggagactgca gcgcggcgtt tagcgcgggg gtcaccccca tccgaggcaa gctcctcggc     6960

gagccagcta tcggcaccat cgctgcgagc cacctgcacc acccacggca aagcctatga     7020

tgtggacatg gtggatgcta acctgttcat ggggggcgat gtgactcgga tagagtctgg     7080

gtccaaagtg gtcgttctgg actctctcga cccaatggtc gaagaaagga gcgaccttga     7140

gccttcgata ccatcagaat acatgctccc caagaagagg ttcccaccag ctttaccggc     7200

ctgggcacgg cctgattaca acccaccgct tgtggaatcg tggaaaaggc cagattacca     7260

accggccact gttgcgggct gtgctctccc tcctcctagg aaaaccccga cgcctccccc     7320

aaggaggcgc cggacagtgg gcctaagtga ggactccata ggagatgccc ttcaacagct     7380

ggccattaag tcctttggcc agcccccccc aagcggcgat tcaggccttt ccacgggggc     7440

gggcgctgcc gattccggca gtcagacgcc tcctgatgag ttggcccttt cggagacagg     7500

ttccatctct tccatgcccc ccctcgaggg ggagcttgga gatccagacc tggagcctga     7560

gcaggtagag ccccaacccc ccccccaggg gggggtggca gctcccggct cggactcggg     7620

gtcctggtct acttgctccg aggaggacga ctccgtcgtg tgctgctcca tgtcatactc     7680

ctggaccggg gctctaataa ctccctgtag ccccgaagag gaaaagttgc caatcaaccc     7740

tttgagtaac tcgctgttgc gataccataa caaggtgtac tgtacaacat caaagagcgc     7800

ctcacagagg gctaaaaagg taacttttga caggacgcaa gtgctcgacg cccattatga     7860

ctcagtctta aaggacatca agctagcggc ttccaaggtc agcgcaaggc tcctcacctt     7920

ggaggaggcg tgccagttga ctccacccca ttctgcaaga tccaagtatg gattcggggc     7980

caaggaggtc cgcagcttgt ccgggagggc cgttaaccac atcaagtccg tgtggaagga     8040

cctcctggaa gacccacaaa caccaattcc cacaaccatc atggccaaaa atgaggtgtt     8100

ctgcgtggac cccgccaagg ggggtaagaa accagctcgc ctcatcgttt accctgacct     8160

cggcgtccgg gtctgcgaga aaatggccct ctatgacatt acacaaaagc ttcctcaggc     8220

ggtaatggga gcttcctatg gcttccagta ctcccctgcc caacgggtgg agtatctctt     8280

gaaagcatgg gcggaaaaga aggaccccat gggtttttcg tatgataccc gatgcttcga     8340

ctcaaccgtc actgagagag acatcaggac cgaggagtcc atataccagg cctgctccct     8400

gcccgaggag gcccgcactg ccatacactc gctgactgag agactttacg taggagggcc     8460

catgttcaac agcaagggtc aaacctgcgg ttacagacgt tgccgcgcca gcggggtgct     8520

aaccactagc atgggtaaca ccatcacatg ctatgtgaaa gccctagcgg cctgcaaggc     8580

tgcggggata gttgcgccca caatgctggt atgcggcgat gacctagtag tcatctcaga     8640

aagccagggg actgaggagg acgagcggaa cctgagagcc ttcacggagg ccatgaccag     8700

gtactctgcc cctcctggtg atccccccag accggaatat gacctggagc taataacatc     8760

ctgttcctca aatgtgtctg tggcgttggg cccgcggggc cgccgcagat actacctgac     8820

cagagaccca accactccac tcgcccgggc tgcctgggaa acagttagac actcccctat     8880

caattcatgg ctgggaaaca tcatccagta tgctccaacc atatgggttc gcatggtcct     8940

aatgacacac ttcttctcca ttctcatggt ccaagacacc ctggaccaga acctcaactt     9000

tgagatgtat ggatcagtat actccgtgaa tcctttggac cttccagcca taattgagag     9060

gttacacggg cttgacgcct tttctatgca cacatactct caccacgaac tgacgcgggt     9120

ggcttcagcc ctcagaaaac ttggggcgcc acccctcagg gtgtggaaga gtcgggctcg     9180

cgcagtcagg gcgtccctca tctcccgtgg agggaaagcg gccgtttgcg gccgatatct     9240

cttcaattgg gcggtgaaga ccaagctcaa actcactcca ttgccggagg cgcgcctact     9300

ggacttatcc agttggttca ccgtcggcgc cggcgggggc gacatttttc acagcgtgtc     9360

gcgcgcccga ccccgctcat tactcttcgg cctactccta cttttcgtag gggtaggcct     9420

cttcctactc cccgctcggt agagcggcac acactaggta cactccatag ctaactgttc     9480

cttttttttt tttttttttt tttttttttt tttttttttt ttttcttttt tttttttttc     9540

cctctttctt cccttctcat cttattctac tttctttctt ggtggctcca tcttagccct     9600

agtcacggct agctgtgaaa ggtccgtgag ccgcatgact gcagagagtg ccgtaactgg     9660

tctctctgca gatcatgt                                                   9678


<210>  6
<211>  9678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  6
acccgcccct aataggggcg acactccgcc atgaatcact cccctgtgag gaactactgt       60

cttcacgcag aaagcgtcta gccatggcgt tagtatgagt gtcgtacagc ctccaggccc      120

ccccctcccg ggagagccat agtggtctgc ggaaccggtg agtacaccgg aattgccggg      180

aagactgggt cctttcttgg ataaacccac tctatgcccg gccatttggg cgtgcccccg      240

caagactgct agccgagtag cgttgggttg cgaaaggcct tgtggtactg cctgataggg      300

tgcttgcgag tgccccggga ggtctcgtag accgtgcacc atgagcacaa atcctaaacc      360

tcaaagaaaa accaaaagaa acaccaaccg tcgcccacaa gacgttaagt ttccgggcgg      420

cggccagatc gttggcggag tatacttgtt gccgcgcagg ggccccaggt tgggtgtgcg      480

cgcgacaagg aagacttcgg agcggtccca gccacgtgga aggcgccagc ccatccctaa      540

agatcggcgc tccactggca aatcctgggg aaaaccagga tacccctggc ccctatacgg      600

gaatgaggga ctcggctggg caggatggct cctgtccccc cgaggttccc gtccctcttg      660

gggccccaat gacccccggc ataggtcgcg caacgtgggt aaggtcatcg ataccctaac      720

gtgcggcttt gccgacctca tggggtacat ccctgtcgtg ggcgccccgc tcggcggcgt      780

cgccagagct ctcgcgcatg gcgtgagagt cctggaggac ggggttaatt ttgcaacagg      840

gaacttaccc ggttgctcct tttctatctt cttgctggcc ctgctgtcct gcatcaccac      900

cccggtctcc gctgccgaag tgaagaacat cagtaccggc tacatggtga ctaacgactg      960

caccaatgac agcattacct ggcagctcca ggctgctgtc ctccacgtcc ccgggtgcgt     1020

cccgtgcgag aaagtgggga atgcatctca gtgctggata ccggtctcac cgaatgtggc     1080

cgtgcagcgg cccggcgccc tcacgcaggg cttgcggacg cacatcgaca tggttgtgat     1140

gtccgccacg ctctgctctg ccctctacgt gggggacctc tgcggtgggg tgatgctcgc     1200

agcccaaatg ttcattgtct cgccgcagca ccactggttt gtccaagact gcaattgctc     1260

catctaccct ggtaccatca ctggacaccg catggcatgg gacatgatga tgaactggtc     1320

gcccacggct accatgatct tggcgtacgc gatgcgtgtc cccgaggtca ttatagacat     1380

cattagcggg gctcattggg gcgtcatgtt cggcttggcc tacttctcta tgcagggagc     1440

gtgggcgaaa gtcgttgtca tccttctgtt ggccgccggg gtggacgcgc gcacccatac     1500

tgttgggggt tctgccgcgc agaccaccgg gcgcctcacc agcttatttg acatgggccc     1560

caggcagaaa atccagctcg ttaacaccaa tggcagctgg cacatcaacc gcaccgccct     1620

gaactgcaat gactccttgc acaccggctt tatcgcgtct ctgttctaca cccacagctt     1680

caactcgtca ggatgtcccg aacgcatgtc cgcctgccgc agtatcgagg ccttccgggt     1740

gggatggggc gccttgcaat atgaggataa tgtcaccaat ccagaggata tgagacccta     1800

ttgctggcac tacccaccaa ggcagtgtgg cgtggtctcc gcgaagactg tgtgtggccc     1860

agtgtactgt ttcaccccca gcccagtggt agtgggcacg accgacaggc ttggagcgcc     1920

cacttacacg tggggggaga atgagacaga tgtcttccta ttgaacagca ctcgaccacc     1980

gctggggtca tggttcggct gcacgtggat gaactcttct ggctacacca agacttgcgg     2040

cgcaccaccc tgccgtacta gagctgactt caacgccagc acggacctgt tgtgccccac     2100

ggactgtttt aggaagcatc ctgataccac ttacctcaaa tgcggctctg ggccctggct     2160

cacgccaagg tgcctgatcg actaccccta caggctctgg cattacccct gcacagttaa     2220

ctataccatc ttcaaaataa ggatgtatgt gggaggggtt gagcacaggc tcacggctgc     2280

atgcaatttc actcgtgggg atcgttgcaa cttggaggac agagacagaa gtcaactgtc     2340

tcctttgttg cactccacca cggaatgggc cattttacct tgctcttact cggacctgcc     2400

cgccttgtcg actggtcttc tccacctcca ccaaaacatc gtggacgtac aattcatgta     2460

tggcctatca cctgccctca caaaatacat cgtccgatgg gagtgggtaa tactcttatt     2520

cctgctctta gcggacgcca gggtttgcgc ctgcttatgg atgctcatct tgttgggcca     2580

ggccgaagca gcactagaga agctggtcat cttgcacgct gcgagcgcag ctagctgcaa     2640

tggcttccta tattttgtca tctttttcgt ggctgcttgg tacatcaagg gtcgggtagt     2700

ccccttagct acctattccc tcactggcct gtggtccttt agcctactgc tcctagcatt     2760

gccccaacag gcttatgctt atgacgcatc tgtgcatggc cagataggag cggctctgct     2820

ggtaatgatc actctcttta ctctcacccc cgggtataag acccttctca gccggttttt     2880

gtggtggttg tgctatcttc tgaccctggg ggaagctatg gtccaggagt gggcaccacc     2940

tatgcaggtg cgcggtggcc gtgatggcat catatgggcc gtcgccatat tctacccagg     3000

tgtggtgttt gacataacca agtggctctt ggcggtgctt gggcctgctt acctcctaaa     3060

aggtgctttg acgcgcgtgc cgtacttcgt cagggctcac gctctactga ggatgtgcac     3120

catggcaagg catctcgcgg ggggcaggta cgtccagatg gcgctactag cccttggcag     3180

gtggactggc acttacatct atgaccacct cacccctatg tcggattggg ctgctagtgg     3240

cctgcgggac ctggcggtcg ccgttgagcc tatcatcttc agtccgatgg agaagaaagt     3300

cattgtctgg ggagcggaga cagctgcttg tggggacatt ttacacggac ttcccgtgtc     3360

cgcccgactt ggtcgggagg tcctccttgg cccagctgat ggctatacct ccaaggggtg     3420

gagtcttctc gcccccatca ctgcttacgc ccagcagaca cgtggccttt tgggcaccat     3480

agtggtgagc atgacggggc gcgacaagac agaacaggct ggggaaattc aggtcctgtc     3540

cacagtcact cagtccttcc tcggaacatc catctcgggg gttttgtgga ctgtctacca     3600

tggagctggc aacaagactc tggccggctc acggggtccg gtcacgcaga tgtactccag     3660

tgctgagggg gacttagtag ggtggcccag cccccctggg actaaatctt tggagccgtg     3720

cacgtgtgga gcggtcgacc tgtacctggt cacgcggaac gctgatgtca tcccggctcg     3780

aagacgcggg gacaaacggg gagcgctact ctccccgaga cctctttcca ccttgaaggg     3840

gtcctcagga ggcccggtgc tatgccccag gggccacgct gtcggagtct tccgggcagc     3900

tgtgtgctct cggggcgtgg ctaagtccat agatttcatc cccgttgaga cactcgacat     3960

cgtcacgcgg tcccccacct ttagtgacaa cagcacacca cctgctgtgc cccagaccta     4020

tcaggtcggg tacttgcatg ccccgactgg cagtggaaag agcaccaaag ttcctgtcgc     4080

atatgctgct caggggtata aagtgctagt gcttaatccc tcagtggctg ccaccctggg     4140

gtttggggcg tacttgtcta aggcacatgg catcaatccc aacattagga ctggagtcag     4200

gactgtgacg accggggcgc ccatcacgta ctccacatat ggcaaattcc tcgccgatgg     4260

gggctgtgcg ggcggcgcct acgacatcat catatgtgat gaatgccatg ccgtggactc     4320

taccaccatc cttggcatcg gaacagtcct tgatcaagca gagacagctg gggtcagact     4380

aactgtgctg gctacagcta cgccccctgg gtcagtgaca accccccacc ccaacataga     4440

ggaggtggcc cttgggcagg agggcgagat ccccttctat gggagggcga ttcccctgtc     4500

ttacatcaag ggaggaagac atctgatctt ctgccattca aagaaaaagt gtgacgagct     4560

cgcggcggcc cttcggggta tgggcttgaa ctcagtggca tactacagag ggttggacgt     4620

ctccgtaata ccaactcagg gagacgtagt ggtcgtcgcc accgacgccc tcatgacagg     4680

gtatactggg gactttgact ccgtgatcga ctgcaacgta gcggtcactc aagttgtaga     4740

cttcagttta gaccccacat tcaccataac cacacagatt gtccctcaag acgctgtctc     4800

acgtagccag cgccggggtc gcacgggtag gggaagactg ggcatttata ggtatgtttc     4860

cactggtgag cgagcctcag gaatgtttga cagtgtagtg ctctgtgagt gctacgacgc     4920

aggggccgca tggtatgagc tcacaccatc ggagaccacc gtcaggctca gggcgtattt     4980

caacacgccc ggtttgcctg tgtgccaaga ccatcttgag ttttgggagg cagttttcac     5040

cggcctcaca cacatagatg cccacttcct ttcccaaaca aagcaatcgg gggaaaattt     5100

cgcatactta acagcctacc aggctacagt gtgcgctagg gccaaagccc cccccccgtc     5160

ctgggacgtc atgtggaagt gtttgactcg actcaagccc acactcgtgg gccccacacc     5220

tctcctgtac cgcttgggct ctgttaccaa cgaggtcacc ctcacacatc ccgtgacgaa     5280

atacatcgcc acctgcatgc aagccgacct tgaggtcatg accagcacat gggtcttggc     5340

agggggagtc ttggcggccg tcgccgcgta ttgcctggcg accgggtgtg tttgcatcat     5400

cggccgcttg cacattaacc agcgagccgt cgttgcgccg gacaaggagg tcctctatga     5460

ggcttttgat gagatggagg aatgtgcctc tagggcggct ctcattgaag aggggcagcg     5520

gatagccgag atgctgaagt ccaagatcca aggcttattg cagcaagctt ccaaacaagc     5580

tcaagacata caacccactg tgcaggcttc atggcccaag gtagaacaat tctgggccaa     5640

acacatgtgg aacttcatta gcggcatcca atacctcgca ggactatcaa cactgccagg     5700

gaaccctgca gtagcttcca tgatggcgtt cagtgccgcc ctcaccagtc cgctgtcaac     5760

aagcaccact atccttctca acattttggg gggctggcta gcatcccaaa ttgcaccacc     5820

cgcgggggcc actggcttcg ttgtcagtgg cctagtggga gctgccgtag gcagtatagg     5880

cttaggtaag gtgctagtgg acatcctggc agggtatggt gcgggcattt cgggggctct     5940

cgtcgcattc aagatcatgt ctggcgagaa gccctccatg gaggatgtcg tcaacttgct     6000

gcctggaatt ctgtctccgg gtgccttggt agtgggagtc atctgcgcgg ccattctgcg     6060

ccgacacgtg ggaccggggg aaggcgccgt ccaatggatg aatagactca ttgcctttgc     6120

ttccagagga aatcacgtcg cccccaccca ctacgtgacg gagtcggatg cgtcgcagcg     6180

tgtgacccaa ctacttggct cccttaccat aaccagcctg ctcagaagac tccacaactg     6240

gattactgag gactgcccca tcccatgcgg cggctcgtgg ctccgcgatg tgtgggactg     6300

ggtttgcacc atcctaacag actttaaaaa ttggctgacc tccaaattat tcccaaagat     6360

gcccggcctc ccctttgtct cctgtcaaaa ggggtacaag ggcgtgtggg ccggcactgg     6420

catcatgacc acacggtgtc cttgcggcgc caatatctct ggcaatgtcc gcttgggctc     6480

catgagaatc acggggccta agacctgcat gaatatctgg caggggacct ttcctatcaa     6540

ttgttacacg gagggccagt gcgtgccgaa acccgcgcca aactttaagg tcgccatctg     6600

gagggtggcg gcctcagagt acgcggaggt gacgcagcac gggtcatacc actacataac     6660

aggactcacc actgataact tgaaagtccc ctgccaacta ccctctcccg agttcttttc     6720

ctgggtggac ggagtgcaga tccataggtt tgcccccaca ccgaagccgt ttttccggga     6780

tgaggtctcg ttctgcgttg ggcttaattc atttgtcgtc gggtcccagc ttccttgcga     6840

ccctgaaccc gacacagacg tattgatgtc catgctaaca gatccatctc atatcacggc     6900

ggagactgca gcgcggcgtt tagcgcgggg gtcaccccca tccgaggcaa gctcctcggc     6960

gagccagcta tcggcaccat cgctgcgagc cacctgcacc acccacggca aagcctatga     7020

tgtggacatg gtggatgcta acctgttcat ggggggcgat gtgactcgga tagagtctgg     7080

gtccaaagtg gtcgttctgg actctctcga cccaatggtc gaagaaagga gcgaccttga     7140

gccttcgata ccatcagaat acatgctccc caagaagagg ttcccaccag ctttaccggc     7200

ctgggcacgg cctgattaca acccaccgct tgtggaatcg tggaaaaggc cagattacca     7260

accggccact gttgcgggct gtgctctccc tcctcctagg aaaaccccga cgcctccccc     7320

aaggaggcgc cggacagtgg gcctaagtga ggactccata ggagatgccc ttcaacagct     7380

ggccattaag tcctttggcc agcccccccc aagcggcgat tcaggccttt ccacgggggc     7440

gggcgctgcc gattccggca gtcagacgcc tcctgatgag ttggcccttt cggagacagg     7500

ttccatctct tccatgcccc ccctcgaggg ggagcttgga gatccagacc tggagcctga     7560

gcaggtagag ccccaacccc ccccccaggg gggggtggca gctcccggct cggactcggg     7620

gtcctggtct acttgctccg aggaggacga ctccgtcgtg tgctgctcca tgtcatactc     7680

ctggaccggg gctctaataa ctccttgtag tcccgaagag gagaagttac cgattaaccc     7740

cttgagcaac tccctgttgc gatatcacaa caaggtgtac tgtaccacaa caaagagcgc     7800

ctcactaagg gctaaaaagg taacttttga taggatgcaa gtgctcgact cctactacga     7860

ctcagtctta aaggacatta agctagcggc ctccaaggtc accgcaaggc tcctcaccat     7920

ggaggaggct tgccagttaa ccccacccca ttctgcaaga tctaaatatg ggtttggggc     7980

taaggaggtc cgcagcttgt ccgggagggc cgttaaccac atcaagtccg tgtggaagga     8040

cctcctggag gactcagaaa caccaattcc cacaaccatt atggccaaaa atgaggtgtt     8100

ctgcgtggac cccaccaagg ggggcaagaa agcagctcgc cttatcgttt accctgacct     8160

cggcgtcagg gtctgcgaga agatggccct ttatgacatt acacaaaaac ttcctcaggc     8220

ggtgatggga gcttcctatg gcttccagta ctcccctgcc caacgggtgg agtatctctt     8280

gaaagcatgg gcggaaaaga aggaccccat gggtttttcg tatgataccc gatgcttcga     8340

ctcaaccgtc actgagagag acatcaggac cgaggagtcc atataccagg cctgctccct     8400

gcccgaggag gcccgcactg ccatacactc gctgactgag agactttacg taggagggcc     8460

catgttcaac agcaagggtc aaacctgcgg ttacagacgt tgccgcgcca gcggggtgct     8520

aaccactagc atgggtaaca ccatcacatg ctatgtgaaa gccctagcgg cctgcaaggc     8580

tgcggggata gttgcgccca caatgctggt atgcggcgat gacctagtag tcatctcaga     8640

aagccagggg actgaggagg acgagcggaa cctgagagcc ttcacggagg ccatgaccag     8700

gtactctgcc cctcctggtg atccccccag accggaatat gacctggagc taataacatc     8760

ctgttcctca aatgtgtctg tggcgttggg cccgcggggc cgccgcagat actacctgac     8820

cagagaccca accactccac tcgcccgggc tgcctgggaa acagttagac actcccctat     8880

caattcatgg ctgggaaaca tcatccagta tgctccaacc atatgggttc gcatggtcct     8940

aatgacacac ttcttctcca ttctcatggt ccaagacacc ctggaccaga acctcaactt     9000

tgagatgtat ggatcagtat actccgtgaa tcctttggac cttccagcca taattgagag     9060

gttacacggg cttgacgcct tttctatgca cacatactct caccacgaac tgacgcgggt     9120

ggcttcagcc ctcagaaaac ttggggcgcc acccctcagg gtgtggaaga gtcgggctcg     9180

cgcagtcagg gcgtccctca tctcccgtgg agggaaagcg gccgtttgcg gccgatatct     9240

cttcaattgg gcggtgaaga ccaagctcaa actcactcca ttgccggagg cgcgcctact     9300

ggacttatcc agttggttca ccgtcggcgc cggcgggggc gacatttttc acagcgtgtc     9360

gcgcgcccga ccccgctcat tactcttcgg cctactccta cttttcgtag gggtaggcct     9420

cttcctactc cccgctcggt agagcggcac acactaggta cactccatag ctaactgttc     9480

cttttttttt tttttttttt tttttttttt tttttttttt ttttcttttt tttttttttc     9540

cctctttctt cccttctcat cttattctac tttctttctt ggtggctcca tcttagccct     9600

agtcacggct agctgtgaaa ggtccgtgag ccgcatgact gcagagagtg ccgtaactgg     9660

tctctctgca gatcatgt                                                   9678


<210>  7
<211>  9678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  7
acccgcccct aataggggcg acactccgcc atgaatcact cccctgtgag gaactactgt       60

cttcacgcag aaagcgtcta gccatggcgt tagtatgagt gtcgtacagc ctccaggccc      120

ccccctcccg ggagagccat agtggtctgc ggaaccggtg agtacaccgg aattgccggg      180

aagactgggt cctttcttgg ataaacccac tctatgcccg gccatttggg cgtgcccccg      240

caagactgct agccgagtag cgttgggttg cgaaaggcct tgtggtactg cctgataggg      300

tgcttgcgag tgccccggga ggtctcgtag accgtgcacc atgagcacaa atcctaaacc      360

tcaaagaaaa accaaaagaa acaccaaccg tcgcccacaa gacgttaagt ttccgggcgg      420

cggccagatc gttggcggag tatacttgtt gccgcgcagg ggccccaggt tgggtgtgcg      480

cgcgacaagg aagacttcgg agcggtccca gccacgtgga aggcgccagc ccatccctaa      540

agatcggcgc tccactggca aatcctgggg aaaaccagga tacccctggc ccctatacgg      600

gaatgaggga ctcggctggg caggatggct cctgtccccc cgaggttccc gtccctcttg      660

gggccccaat gacccccggc ataggtcgcg caacgtgggt aaggtcatcg ataccctaac      720

gtgcggcttt gccgacctca tggggtacat ccctgtcgtg ggcgccccgc tcggcggcgt      780

cgccagagct ctcgcgcatg gcgtgagagt cctggaggac ggggttaatt ttgcaacagg      840

gaacttaccc ggttgctcct tttctatctt cttgctggcc ctgctgtcct gcatcaccac      900

cccggtctcc gctgccgaag tgaagaacat cagtaccggc tacatggtga ctaacgactg      960

caccaatgac agcattacct ggcagctcca ggctgctgtc ctccacgtcc ccgggtgcgt     1020

cccgtgcgag aaagtgggga atgcatctca gtgctggata ccggtctcac cgaatgtggc     1080

cgtgcagcgg cccggcgccc tcacgcaggg cttgcggacg cacatcgaca tggttgtgat     1140

gtccgccacg ctctgctctg ccctctacgt gggggacctc tgcggtgggg tgatgctcgc     1200

agcccaaatg ttcattgtct cgccgcagca ccactggttt gtccaagact gcaattgctc     1260

catctaccct ggtaccatca ctggacaccg catggcatgg gacatgatga tgaactggtc     1320

gcccacggct accatgatct tggcgtacgc gatgcgtgtc cccgaggtca ttatagacat     1380

cattagcggg gctcattggg gcgtcatgtt cggcttggcc tacttctcta tgcagggagc     1440

gtgggcgaaa gtcgttgtca tccttctgtt ggccgccggg gtggacgcgc gcacccatac     1500

tgttgggggt tctgccgcgc agaccaccgg gcgcctcacc agcttatttg acatgggccc     1560

caggcagaaa atccagctcg ttaacaccaa tggcagctgg cacatcaacc gcaccgccct     1620

gaactgcaat gactccttgc acaccggctt tatcgcgtct ctgttctaca cccacagctt     1680

caactcgtca ggatgtcccg aacgcatgtc cgcctgccgc agtatcgagg ccttccgggt     1740

gggatggggc gccttgcaat atgaggataa tgtcaccaat ccagaggata tgagacccta     1800

ttgctggcac tacccaccaa ggcagtgtgg cgtggtctcc gcgaagactg tgtgtggccc     1860

agtgtactgt ttcaccccca gcccagtggt agtgggcacg accgacaggc ttggagcgcc     1920

cacttacacg tggggggaga atgagacaga tgtcttccta ttgaacagca ctcgaccacc     1980

gctggggtca tggttcggct gcacgtggat gaactcttct ggctacacca agacttgcgg     2040

cgcaccaccc tgccgtacta gagctgactt caacgccagc acggacctgt tgtgccccac     2100

ggactgtttt aggaagcatc ctgataccac ttacctcaaa tgcggctctg ggccctggct     2160

cacgccaagg tgcctgatcg actaccccta caggctctgg cattacccct gcacagttaa     2220

ctataccatc ttcaaaataa ggatgtatgt gggaggggtt gagcacaggc tcacggctgc     2280

atgcaatttc actcgtgggg atcgttgcaa cttggaggac agagacagaa gtcaactgtc     2340

tcctttgttg cactccacca cggaatgggc cattttacct tgctcttact cggacctgcc     2400

cgccttgtcg actggtcttc tccacctcca ccaaaacatc gtggacgtac aattcatgta     2460

tggcctatca cctgccctca caaaatacat cgtccgatgg gagtgggtaa tactcttatt     2520

cctgctctta gcggacgcca gggtttgcgc ctgcttatgg atgctcatct tgttgggcca     2580

ggccgaagca gcactagaga agctggtcat cttgcacgct gcgagcgcag ctagctgcaa     2640

tggcttccta tattttgtca tctttttcgt ggctgcttgg tacatcaagg gtcgggtagt     2700

ccccttagct acctattccc tcactggcct gtggtccttt agcctactgc tcctagcatt     2760

gccccaacag gcttatgctt atgacgcatc tgtgcatggc cagataggag cggctctgct     2820

ggtaatgatc actctcttta ctctcacccc cgggtataag acccttctca gccggttttt     2880

gtggtggttg tgctatcttc tgaccctggg ggaagctatg gtccaggagt gggcaccacc     2940

tatgcaggtg cgcggtggcc gtgatggcat catatgggcc gtcgccatat tctacccagg     3000

tgtggtgttt gacataacca agtggctctt ggcggtgctt gggcctgctt acctcctaaa     3060

aggtgctttg acgcgcgtgc cgtacttcgt cagggctcac gctctactga ggatgtgcac     3120

catggcaagg catctcgcgg ggggcaggta cgtccagatg gcgctactag cccttggcag     3180

gtggactggc acttacatct atgaccacct cacccctatg tcggattggg ctgctagtgg     3240

cctgcgggac ctggcggtcg ccgttgagcc tatcatcttc agtccgatgg agaagaaagt     3300

cattgtctgg ggagcggaga cagctgcttg tggggacatt ttacacggac ttcccgtgtc     3360

cgcccgactt ggtcgggagg tcctccttgg cccagctgat ggctatacct ccaaggggtg     3420

gagtcttctc gcccccatca ctgcttacgc ccagcagaca cgtggccttt tgggcaccat     3480

agtggtgagc atgacggggc gcgacaagac agaacaggct ggggaaattc aggtcctgtc     3540

cacagtcact cagtccttcc tcggaacatc catctcgggg gttttgtgga ctgtctacca     3600

tggagctggc aacaagactc tggccggctc acggggtccg gtcacgcaga tgtactccag     3660

tgctgagggg gacttagtag ggtggcccag cccccctggg actaaatctt tggagccgtg     3720

cacgtgtgga gcggtcgacc tgtacctggt cacgcggaac gctgatgtca tcccggctcg     3780

aagacgcggg gacaaacggg gagcgctact ctccccgaga cctctttcca ccttgaaggg     3840

gtcctcagga ggcccggtgc tatgccccag gggccacgct gtcggagtct tccgggcagc     3900

tgtgtgctct cggggcgtgg ctaagtccat agatttcatc cccgttgaga cactcgacat     3960

cgtcacgcgg tcccccacct ttagtgacaa cagcacacca cctgctgtgc cccagaccta     4020

tcaggtcggg tacttgcatg ccccgactgg cagtggaaag agcaccaaag ttcctgtcgc     4080

atatgctgct caggggtata aagtgctagt gcttaatccc tcagtggctg ccaccctggg     4140

gtttggggcg tacttgtcta aggcacatgg catcaatccc aacattagga ctggagtcag     4200

gactgtgacg accggggcgc ccatcacgta ctccacatat ggcaaattcc tcgccgatgg     4260

gggctgtgcg ggcggcgcct acgacatcat catatgtgat gaatgccatg ccgtggactc     4320

taccaccatc cttggcatcg gaacagtcct tgatcaagca gagacagctg gggtcagact     4380

aactgtgctg gctacagcta cgccccctgg gtcagtgaca accccccacc ccaacataga     4440

ggaggtggcc cttgggcagg agggcgagat ccccttctat gggagggcga ttcccctgtc     4500

ttacatcaag ggaggaagac atctgatctt ctgccattca aagaaaaagt gtgacgagct     4560

cgcggcggcc cttcggggta tgggcttgaa ctcagtggca tactacagag ggttggacgt     4620

ctccgtaata ccaactcagg gagacgtagt ggtcgtcgcc accgacgccc tcatgacagg     4680

gtatactggg gactttgact ccgtgatcga ctgcaacgta gcggtcactc aagttgtaga     4740

cttcagttta gaccccacat tcaccataac cacacagatt gtccctcaag acgctgtctc     4800

acgtagccag cgccggggtc gcacgggtag gggaagactg ggcatttata ggtatgtttc     4860

cactggtgag cgagcctcag gaatgtttga cagtgtagtg ctctgtgagt gctacgacgc     4920

aggggccgca tggtatgagc tcacaccatc ggagaccacc gtcaggctca gggcgtattt     4980

caacacgccc ggtttgcctg tgtgccaaga ccatcttgag ttttgggagg cagttttcac     5040

cggcctcaca cacatagatg cccacttcct ttcccaaaca aagcaatcgg gggaaaattt     5100

cgcatactta acagcctacc aggctacagt gtgcgctagg gccaaagccc cccccccgtc     5160

ctgggacgtc atgtggaagt gtttgactcg actcaagccc acactcgtgg gccccacacc     5220

tctcctgtac cgcttgggct ctgttaccaa cgaggtcacc ctcacacatc ccgtgacgaa     5280

atacatcgcc acctgcatgc aagccgacct tgaggtcatg accagcacat gggtcttggc     5340

agggggagtc ttggcggccg tcgccgcgta ttgcctggcg accgggtgtg tttgcatcat     5400

cggccgcttg cacattaacc agcgagccgt cgttgcgccg gacaaggagg tcctctatga     5460

ggcttttgat gagatggagg aatgtgcctc tagggcggct ctcattgaag aggggcagcg     5520

gatagccgag atgctgaagt ccaagatcca aggcttattg cagcaagctt ccaaacaagc     5580

tcaagacata caacccactg tgcaggcttc atggcccaag gtagaacaat tctgggccaa     5640

acacatgtgg aacttcatta gcggcatcca atacctcgca ggactatcaa cactgccagg     5700

gaaccctgca gtagcttcca tgatggcgtt cagtgccgcc ctcaccagtc cgctgtcaac     5760

aagcaccact atccttctca acattttggg gggctggcta gcatcccaaa ttgcaccacc     5820

cgcgggggcc actggcttcg ttgtcagtgg cctagtggga gctgccgtag gcagtatagg     5880

cttaggtaag gtgctagtgg acatcctggc agggtatggt gcgggcattt cgggggctct     5940

cgtcgcattc aagatcatgt ctggcgagaa gccctccatg gaggatgtcg tcaacttgct     6000

gcctggaatt ctgtctccgg gtgccttggt agtgggagtc atctgcgcgg ccattctgcg     6060

ccgacacgtg ggaccggggg aaggcgccgt ccaatggatg aatagactca ttgcctttgc     6120

ttccagagga aatcacgtcg cccccaccca ctacgtgacg gagtcggatg cgtcgcagcg     6180

tgtgacccaa ctacttggct cccttaccat aaccagcctg ctcagaagac tccacaactg     6240

gattactgag gactgcccca tcccatgcgg cggctcgtgg ctccgcgatg tgtgggactg     6300

ggtttgcacc atcctaacag actttaaaaa ttggctgacc tccaaattat tcccaaagat     6360

gcccggcctc ccctttgtct cctgtcaaaa ggggtacaag ggcgtgtggg ccggcactgg     6420

catcatgacc acacggtgtc cttgcggcgc caatatctct ggcaatgtcc gcttgggctc     6480

catgagaatc acggggccta agacctgcat gaatatctgg caggggacct ttcctatcaa     6540

ttgttacacg gagggccagt gcgtgccgaa acccgcgcca aactttaagg tcgccatctg     6600

gagggtggcg gcctcagagt acgcggaggt gacgcagcac gggtcatacc actacataac     6660

aggactcacc actgataact tgaaagtccc ctgccaacta ccctctcccg agttcttttc     6720

ctgggtggac ggagtgcaga tccataggtt tgcccccaca ccgaagccgt ttttccggga     6780

tgaggtctcg ttctgcgttg ggcttaattc atttgtcgtc gggtcccagc ttccttgcga     6840

ccctgaaccc gacacagacg tattgatgtc catgctaaca gatccatctc atatcacggc     6900

ggagactgca gcgcggcgtt tagcgcgggg gtcaccccca tccgaggcaa gctcctcggc     6960

gagccagcta tcggcaccat cgctgcgagc cacctgcacc acccacggca aagcctatga     7020

tgtggacatg gtggatgcta acctgttcat ggggggcgat gtgactcgga tagagtctgg     7080

gtccaaagtg gtcgttctgg actctctcga cccaatggtc gaagaaagga gcgaccttga     7140

gccttcgata ccatcagaat acatgctccc caagaagagg ttcccaccag ctttaccggc     7200

ctgggcacgg cctgattaca acccaccgct tgtggaatcg tggaaaaggc cagattacca     7260

accggccact gttgcgggct gtgctctccc tcctcctagg aaaaccccga cgcctccccc     7320

aaggaggcgc cggacagtgg gcctaagtga ggactccata ggagatgccc ttcaacagct     7380

ggccattaag tcctttggcc agcccccccc aagcggcgat tcaggccttt ccacgggggc     7440

gggcgctgcc gattccggca gtcagacgcc tcctgatgag ttggcccttt cggagacagg     7500

ttccatctct tccatgcccc ccctcgaggg ggagcttgga gatccagacc tggagcctga     7560

gcaggtagag ccccaacccc ccccccaggg gggggtggca gctcccggct cggactcggg     7620

gtcctggtct acttgctccg aggaggacga ctccgtcgtg tgctgctcca tgtcatactc     7680

ctggaccggg gctctaataa ctccttgtag tcccgaagag gagaagttac cgattaaccc     7740

cttgagcaac tccctgttgc gatatcacaa caaggtgtac tgtaccacaa caaagagcgc     7800

ctcactaagg gctaaaaagg taacttttga taggatgcaa gtgctcgact cctactacga     7860

ctcagtctta aaggacatta agctagcggc ctccaaggtc accgcaaggc tcctcaccat     7920

ggaggaggct tgccagttaa ccccacccca ttctgcaaga tctaaatatg ggtttggggc     7980

taaggaggtc cgcagcttgt ccgggagggc cgttaaccac atcaagtccg tgtggaagga     8040

cctcctggag gactcagaaa caccaattcc cacaaccatt atggccaaaa atgaggtgtt     8100

ctgcgtggac cccaccaagg ggggcaagaa agcagctcgc cttatcgttt accctgacct     8160

cggcgtcagg gtctgcgaga agatggccct ttatgacatt acacaaaaac ttcctcaggc     8220

ggtgatgggg gcttcttatg gattccagta ttcccccgct cagcgggtag agtttctctt     8280

gaaagcatgg gcggaaaaga aggaccctat gggtttttcg tatgataccc gatgctttga     8340

ctcaaccgtc actgagagag acatcaggac tgaggagtcc atatatcggg cctgctcctt     8400

gcccgaggag gcccacactg ccatacactc gctaactgag agactttacg tgggagggcc     8460

tatgttcaac agcaagggcc aaacctgcgg gtacaggcgt tgccgcgcca gcggggtgct     8520

caccactagc atggggaaca ccatcacatg ctacgtgaaa gccttagcgg cttgtaaagc     8580

tgcagggata atcgcgccca caatgctggt atgcggcgat gacttggttg tcatctcaga     8640

aagccagggg accgaggagg acgagcggaa cctgagagcc ttcacggagg ctatgaccag     8700

gtattctgcc cctcctggtg acccccccag accggagtat gatctggagc tgataacatc     8760

ttgctcctca aatgtgtctg tggcgttggg cccgcggggc cgccgcagat actacctgac     8820

cagagaccca accactccac tcgcccgggc tgcctgggaa acagttagac actcccctat     8880

caattcatgg ctgggaaaca tcatccagta tgctccaacc atatgggttc gcatggtcct     8940

aatgacacac ttcttctcca ttctcatggt ccaagacacc ctggaccaga acctcaactt     9000

tgagatgtat ggatcagtat actccgtgaa tcctttggac cttccagcca taattgagag     9060

gttacacggg cttgacgcct tttctatgca cacatactct caccacgaac tgacgcgggt     9120

ggcttcagcc ctcagaaaac ttggggcgcc acccctcagg gtgtggaaga gtcgggctcg     9180

cgcagtcagg gcgtccctca tctcccgtgg agggaaagcg gccgtttgcg gccgatatct     9240

cttcaattgg gcggtgaaga ccaagctcaa actcactcca ttgccggagg cgcgcctact     9300

ggacttatcc agttggttca ccgtcggcgc cggcgggggc gacatttttc acagcgtgtc     9360

gcgcgcccga ccccgctcat tactcttcgg cctactccta cttttcgtag gggtaggcct     9420

cttcctactc cccgctcggt agagcggcac acactaggta cactccatag ctaactgttc     9480

cttttttttt tttttttttt tttttttttt tttttttttt ttttcttttt tttttttttc     9540

cctctttctt cccttctcat cttattctac tttctttctt ggtggctcca tcttagccct     9600

agtcacggct agctgtgaaa ggtccgtgag ccgcatgact gcagagagtg ccgtaactgg     9660

tctctctgca gatcatgt                                                   9678


<210>  8
<211>  9678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  8
acccgcccct aataggggcg acactccgcc atgaatcact cccctgtgag gaactactgt       60

cttcacgcag aaagcgtcta gccatggcgt tagtatgagt gtcgtacagc ctccaggccc      120

ccccctcccg ggagagccat agtggtctgc ggaaccggtg agtacaccgg aattgccggg      180

aagactgggt cctttcttgg ataaacccac tctatgcccg gccatttggg cgtgcccccg      240

caagactgct agccgagtag cgttgggttg cgaaaggcct tgtggtactg cctgataggg      300

tgcttgcgag tgccccggga ggtctcgtag accgtgcacc atgagcacaa atcctaaacc      360

tcaaagaaaa accaaaagaa acaccaaccg tcgcccacaa gacgttaagt ttccgggcgg      420

cggccagatc gttggcggag tatacttgtt gccgcgcagg ggccccaggt tgggtgtgcg      480

cgcgacaagg aagacttcgg agcggtccca gccacgtgga aggcgccagc ccatccctaa      540

agatcggcgc tccactggca aatcctgggg aaaaccagga tacccctggc ccctatacgg      600

gaatgaggga ctcggctggg caggatggct cctgtccccc cgaggttccc gtccctcttg      660

gggccccaat gacccccggc ataggtcgcg caacgtgggt aaggtcatcg ataccctaac      720

gtgcggcttt gccgacctca tggggtacat ccctgtcgtg ggcgccccgc tcggcggcgt      780

cgccagagct ctcgcgcatg gcgtgagagt cctggaggac ggggttaatt ttgcaacagg      840

gaacttaccc ggttgctcct tttctatctt cttgctggcc ctgctgtcct gcatcaccac      900

cccggtctcc gctgccgaag tgaagaacat cagtaccggc tacatggtga ctaacgactg      960

caccaatgac agcattacct ggcagctcca ggctgctgtc ctccacgtcc ccgggtgcgt     1020

cccgtgcgag aaagtgggga atgcatctca gtgctggata ccggtctcac cgaatgtggc     1080

cgtgcagcgg cccggcgccc tcacgcaggg cttgcggacg cacatcgaca tggttgtgat     1140

gtccgccacg ctctgctctg ccctctacgt gggggacctc tgcggtgggg tgatgctcgc     1200

agcccaaatg ttcattgtct cgccgcagca ccactggttt gtccaagact gcaattgctc     1260

catctaccct ggtaccatca ctggacaccg catggcatgg gacatgatga tgaactggtc     1320

gcccacggct accatgatct tggcgtacgc gatgcgtgtc cccgaggtca ttatagacat     1380

cattagcggg gctcattggg gcgtcatgtt cggcttggcc tacttctcta tgcagggagc     1440

gtgggcgaaa gtcgttgtca tccttctgtt ggccgccggg gtggacgcgc gcacccatac     1500

tgttgggggt tctgccgcgc agaccaccgg gcgcctcacc agcttatttg acatgggccc     1560

caggcagaaa atccagctcg ttaacaccaa tggcagctgg cacatcaacc gcaccgccct     1620

gaactgcaat gactccttgc acaccggctt tatcgcgtct ctgttctaca cccacagctt     1680

caactcgtca ggatgtcccg aacgcatgtc cgcctgccgc agtatcgagg ccttccgggt     1740

gggatggggc gccttgcaat atgaggataa tgtcaccaat ccagaggata tgagacccta     1800

ttgctggcac tacccaccaa ggcagtgtgg cgtggtctcc gcgaagactg tgtgtggccc     1860

agtgtactgt ttcaccccca gcccagtggt agtgggcacg accgacaggc ttggagcgcc     1920

cacttacacg tggggggaga atgagacaga tgtcttccta ttgaacagca ctcgaccacc     1980

gctggggtca tggttcggct gcacgtggat gaactcttct ggctacacca agacttgcgg     2040

cgcaccaccc tgccgtacta gagctgactt caacgccagc acggacctgt tgtgccccac     2100

ggactgtttt aggaagcatc ctgataccac ttacctcaaa tgcggctctg ggccctggct     2160

cacgccaagg tgcctgatcg actaccccta caggctctgg cattacccct gcacagttaa     2220

ctataccatc ttcaaaataa ggatgtatgt gggaggggtt gagcacaggc tcacggctgc     2280

atgcaatttc actcgtgggg atcgttgcaa cttggaggac agagacagaa gtcaactgtc     2340

tcctttgttg cactccacca cggaatgggc cattttacct tgctcttact cggacctgcc     2400

cgccttgtcg actggtcttc tccacctcca ccaaaacatc gtggacgtac aattcatgta     2460

tggcctatca cctgccctca caaaatacat cgtccgatgg gagtgggtaa tactcttatt     2520

cctgctctta gcggacgcca gggtttgcgc ctgcttatgg atgctcatct tgttgggcca     2580

ggccgaagca gcactagaga agctggtcat cttgcacgct gcgagcgcag ctagctgcaa     2640

tggcttccta tattttgtca tcttttccgt ggctgcttgg tacatcaagg gtcgggtagt     2700

ccccttagct acctattccc tcactggcct gtggtccttt agcctactgc tcctagcatt     2760

gccccaacag gcttatgctt atgacgcatc tgtgcatggc cagataggag cggctctgct     2820

ggtaatgatc actctcttta ctctcacccc cgggtataag acccttctca gccggttttt     2880

gtggtggttg tgctatcttc tgaccctggg ggaagctatg gtccaggagt gggcaccacc     2940

tatgcaggtg cgcggtggcc gtgatggcat catatgggcc gtcgccatat tctacccagg     3000

tgtggtgttt gacataacca agtggctctt ggcggtgctt gggcctgctt acctcctaaa     3060

aggtgctttg acgcgcgtgc cgtacttcgt cagggctcac gctctactga ggatgtgcac     3120

catggcaagg catctcgcgg ggggcaggta cgtccagatg gcgctactag cccttggcag     3180

gtggactggc acttacatct atgaccacct cacccctatg tcggattggg ctgctagtgg     3240

cctgcgggac ctggcggtcg ccgttgagcc tatcatcttc agtccgatgg agaagaaagt     3300

cattgtctgg ggagcggaga cagctgcttg tggggacatt ttacacggac ttcccgtgtc     3360

cgcccgactt ggtcgggagg tcctccttgg cccagctgat ggctatacct ccaaggggtg     3420

gagtcttctc gcccccatca ctgcttacgc ccagcagaca cgtggccttt tgggcaccat     3480

agtggtgagc atgacggggc gcgacaagac agaacaggct ggggaaattc aggtcctgtc     3540

cacagtcact cagtccttcc tcggaacatc catctcgggg gttttgtgga ctgtctacca     3600

tggagctggc aacaagactc tggccggctc acggggtccg gtcacgcaga tgtactccag     3660

tgctgagggg gacttagtag ggtggcccag cccccctggg actaaatctt tggagccgtg     3720

cacgtgtgga gcggtcgacc tgtacctggt cacgcggaac gctgatgtca tcccggctcg     3780

aagacgcggg gacaaacggg gagcgctact ctccccgaga cctctttcca ccttgaaggg     3840

gtcctcagga ggcccggtgc tatgccccag gggccacgct gtcggagtct tccgggcagc     3900

tgtgtgctct cggggcgtgg ctaagtccat agatttcatc cccgttgaga cactcgacat     3960

cgtcacgcgg tcccccacct ttagtgacaa cagcacacca cctgctgtgc cccagaccta     4020

tcaggtcggg tacttgcatg ccccgactgg cagtggaaag agcaccaaag ttcctgtcgc     4080

atatgctgct caggggtata aagtgctagt gcttaatccc tcagtggctg ccaccctggg     4140

gtttggggcg tacttgtcta aggcacatgg catcaatccc aacattagga ctggagtcag     4200

gactgtgacg accggggcgc ccatcacgta ctccacatat ggcaaattcc tcgccgatgg     4260

gggctgtgcg ggcggcgcct acgacatcat catatgtgat gaatgccatg ccgtggactc     4320

taccaccatc cttggcatcg gaacagtcct tgatcaagca gagacagctg gggtcagact     4380

aactgtgctg gctacagcta cgccccctgg gtcagtgaca accccccacc ccaacataga     4440

ggaggtggcc cttgggcagg agggcgagat ccccttctat gggagggcga ttcccctgtc     4500

ttacatcaag ggaggaagac atctgatctt ctgccattca aagaaaaagt gtgacgagct     4560

cgcggcggcc cttcggggta tgggcttgaa ctcagtggca tactacagag ggttggacgt     4620

ctccgtaata ccaactcagg gagacgtagt ggtcgtcgcc accgacgccc tcatgacagg     4680

gtatactggg gactttgact ccgtgatcga ctgcaacgta gcggtcactc aagttgtaga     4740

cctcagttta gaccccacat tcaccataac cacacagatt gtccctcaag acgctgtctc     4800

acgtagccag cgccggggtc gcacgggtag gggaagactg ggcatttata ggtatgtttc     4860

cactggtgag cgagcctcag gaatgtttga cagtgtagtg ctctgtgagt gctacgacgc     4920

aggggccgca tggtatgagc tcacaccatc ggagaccacc gtcaggctca gggcgtattt     4980

caacacgccc ggtttgcctg tgtgccaaga ccatcttgag ttttgggagg cagttttcac     5040

cggcctcaca cacatagatg cccacttcct ttcccaaaca aagcaatcgg gggaaaattt     5100

cgcatactta acagcctacc aggctacagt gtgcgctagg gccaaagccc cccccccgtc     5160

ctgggacgtc atgtggaagt gtttgactcg actcaagccc acactcgtgg gccccacacc     5220

tctcctgtac cgcttgggct ctgttaccaa cgaggtcacc ctcacacatc ccgtgacgaa     5280

atacatcgcc acctgcatgc aagccgacct tgaggtcatg accagcacat gggtcttggc     5340

agggggagtc ttggcggccg tcgcctcgta ttgcctggcg accgggtgtg tttgcatcat     5400

cggccgcttg cacattaacc agcgagccgt cgttgcgccg gacaaggagg tcctctatga     5460

ggcttttgat gagatggagg aatgtgcctc tagggcggct ctcattgaag aggggcagcg     5520

gatagccgag atgctgaagt ccaagatcca aggcttattg cagcaagctt ccaaacaagc     5580

tcaagacata caacccactg tgcaggcttc atggcccaag gtagaacaat tctgggccaa     5640

acacatgtgg aacttcatta gcggcatcca atacctcgca ggactatcaa cactgccagg     5700

gaaccctgca gtagcttcca tgatggcgtt cagtgccgcc ctcaccagtc cgctgtcaac     5760

aagcaccact atccttctca acattttggg gggctggcta gcatcccaaa ttgcaccacc     5820

cgcgggggcc actggcttcg ttgtcagtgg cctagtggga gctgccgtag gcagtatagg     5880

cttaggtaag gtgctagtgg acatcctggc agggtatggt gcgggcattt cgggggctct     5940

cgtcgcattc aagatcatgt ctggcgagaa gccctccatg gaggatgtcg tcaacttgct     6000

gcctggaatt ctgtctccgg gtgccttggt agtgggagtc atctgcgcgg ccattctgcg     6060

ccgacacgtg ggaccggggg aaggcgccgt ccaatggatg aatagactca ttgcctttgc     6120

ttccagagga aatcacgtcg cccccaccca ctacgtgacg gagtcggatg cgtcgcagcg     6180

tgtgacccaa ctacttggct cccttaccat aaccagcctg ctcagaagac tccacaactg     6240

gattactgag gactgcccca tcccatgcgg cggctcgtgg ctccgcgatg tgtgggactg     6300

ggtttgcacc atcctaacag actttaaaaa ttggctgacc tccaaattat tcccaaagat     6360

gcccggcctc ccctttgtct cctgtcaaaa ggggtacaag ggcgtgtggg ccggcactgg     6420

catcatgacc acacggtgtc cttgcggcgc caatatctct ggcaatgtcc gcttgggctc     6480

catgagaatc acggggccta agacctgcat gaatatctgg caggggacct ttcctatcaa     6540

ttgttacacg gagggccagt gcgtgccgaa acccgcgcca aactttaagg tcgccatctg     6600

gagggtggcg gcctcagagt acgcggaggt gacgcagcac gggtcatacc actacataac     6660

aggactcacc actgataact tgaaagtccc ctgccaacta ccctctcccg agttcttttc     6720

ctgggtggac ggagtgcaga tccataggtt tgcccccaca ccgaagccgt ttttccggga     6780

tgaggtctcg ttctgcgttg ggcttaattc atttgtcgtc gggtcccagc ttccttgcga     6840

ccctgaaccc gacacagacg tattgatgtc catgctaaca gatccatctc atatcacggc     6900

ggagactgca gcgcggcgtt tagcgcgggg gtcaccccca tccgaggcaa gctcctcggc     6960

gagccagcta tcggcaccat cgctgcgagc cacctgcacc acccacggca aagcctatga     7020

tgtggacatg gtggatgcta acctgttcat ggggggcgat gtgactcgga tagagtctgg     7080

gtccaaagtg gtcgttctgg actctctcga cccaatggtc gaagaaagga gcgaccttga     7140

gccttcgata ccatcagaat acatgctccc caagaagagg ttcccaccag ctttaccggc     7200

ctgggcacgg cctgattaca acccaccgct tgtggaatcg tggaaaaggc cagattacca     7260

accggccact gttgcgggct gtgctctccc tcctcctagg aaaaccccga cgcctccccc     7320

aaggaggcgc cggacagtgg gcctaagtga ggactccata ggagatgccc ttcaacagct     7380

ggccattaag tcctttggcc agcccccccc aagcggcgat tcaggccttt ccacgggggc     7440

gggcgctgcc gattccggca gtcagacgcc tcctgatgag ttggcccttt cggagacagg     7500

ttccatctct tccatgcccc ccctcgaggg ggagcttgga gatccagacc tggagcctga     7560

gcaggtagag ccccaacccc ccccccaggg gggggtggca gctcccggct cggactcggg     7620

gtcctggtct acttgctccg aggaggacga ctccgtcgtg tgctgctcca tgtcatactc     7680

ctggaccggg gctctaataa ctccttgtag tcccgaagag gagaagttac cgattaaccc     7740

cttgagcaac tccctgttgc gatatcacaa caaggtgtac tgtaccacaa caaagagcgc     7800

ctcactaagg gctaaaaagg taacttttga taggatgcaa gtgctcgact cctactacga     7860

ctcagtctta aaggacatta agctagcggc ctccaaggtc accgcaaggc tcctcaccat     7920

ggaggaggct tgccagttaa ccccacccca ttctgcaaga tctaaatatg ggtttggggc     7980

taaggaggtc cgcagcttgt ccgggagggc cgttaaccac atcaagtccg tgtggaagga     8040

cctcctggag gactcagaaa caccaattcc cacaaccatt atggccaaaa atgaggtgtt     8100

ctgcgtggac cccaccaagg ggggcaagaa agcagctcgc cttatcgttt accctgacct     8160

cggcgtcagg gtctgcgaga agatggccct ttatgacatt acacaaaaac ttcctcaggc     8220

ggtgatgggg gcttcttatg gattccagta ttcccccgct cagcgggtag agtttctctt     8280

gaaagcatgg gcggaaaaga aggaccctat gggtttttcg tatgataccc gatgctttga     8340

ctcaaccgtc actgagagag acatcaggac tgaggagtcc atatatcggg cctgctcctt     8400

gcccgaggag gcccacactg ccatacactc gctaactgag agactttacg tgggagggcc     8460

tatgttcaac agcaagggcc aaacctgcgg gtacaggcgt tgccgcgcca gcggggtgct     8520

caccactagc atggggaaca ccatcacatg ctacgtgaaa gccttagcgg cttgtaaagc     8580

tgcagggata atcgcgccca caatgctggt atgcggcgat gacttggttg tcatctcaga     8640

aagccagggg accgaggagg acgagcggaa cctgagagcc ttcacggagg ctatgaccag     8700

gtattctgcc cctcctggtg acccccccag accggagtat gatctggagc tgataacatc     8760

ttgctcctca aatgtgtctg tggcgttggg cccgcggggc cgccgcagat actacctgac     8820

cagagaccca accactccac tcgcccgggc tgcctgggaa acagttagac actcccctat     8880

caattcatgg ctgggaaaca tcatccagta tgctccaacc atatgggttc gcatggtcct     8940

aatgacacac ttcttctcca ttctcatggt ccaagacacc ctggaccaga acctcaactt     9000

tgagatgtat ggatcagtat actccgtgaa tcctttggac cttccagcca taattgagag     9060

gttacacggg cttgacgcct tttctatgca cacatactct caccacgaac tgacgcgggt     9120

ggcttcagcc ctcagaaaac ttggggcgcc acccctcagg gtgtggaaga gtcgggctcg     9180

cgcagtcagg gcgtccctca tctcccgtgg agggaaagcg gccgtttgcg gccgatatct     9240

cttcaattgg gcggtgaaga ccaagctcaa actcactcca ttgccggagg cgcgcctact     9300

ggacttatcc agttggttca ccgtcggcgc cggcgggggc gacatttttc acagcgtgtc     9360

gcgcgcccga ccccgctcat tactcttcgg cctactccta cttttcgtag gggtaggcct     9420

cttcctactc cccgctcggt agagcggcac acactaggta cactccatag ctaactgttc     9480

cttttttttt tttttttttt tttttttttt tttttttttt ttttcttttt tttttttttc     9540

cctctttctt cccttctcat cttattctac tttctttctt ggtggctcca tcttagccct     9600

agtcacggct agctgtgaaa ggtccgtgag ccgcatgact gcagagagtg ccgtaactgg     9660

tctctctgca gatcatgt                                                   9678


<210>  9
<211>  9678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  9
acccgcccct aataggggcg acactccgcc atgaatcact cccctgtgag gaactactgt       60

cttcacgcag aaagcgtcta gccatggcgt tagtatgagt gtcgtacagc ctccaggccc      120

ccccctcccg ggagagccat agtggtctgc ggaaccggtg agtacaccgg aattgccggg      180

aagactgggt cctttcttgg ataaacccac tctatgcccg gccatttggg cgtgcccccg      240

caagactgct agccgagtag cgttgggttg cgaaaggcct tgtggtactg cctgataggg      300

tgcttgcgag tgccccggga ggtctcgtag accgtgcacc atgagcacaa atcctaaacc      360

tcaaagaaaa accaaaagaa acaccaaccg tcgcccacaa gacgttaagt ttccgggcgg      420

cggccagatc gttggcggag tatacttgtt gccgcgcagg ggccccaggt tgggtgtgcg      480

cgcgacaagg aagacttcgg agcggtccca gccacgtgga aggcgccagc ccatccctaa      540

agatcggcgc tccactggca aatcctgggg aaaaccagga tacccctggc ccctatacgg      600

gaatgaggga ctcggctggg caggatggct cctgtccccc cgaggttccc gtccctcttg      660

gggccccaat gacccccggc ataggtcgcg caacgtgggt aaggtcatcg ataccctaac      720

gtgcggcttt gccgacctca tggggtacat ccctgtcgtg ggcgccccgc tcggcggcgt      780

cgccagagct ctcgcgcatg gcgtgagagt cctggaggac ggggttaatt ttgcaacagg      840

gaacttaccc ggttgctcct tttctatctt cttgctggcc ctgctgtcct gcatcaccac      900

cccggtctcc gctgccgaag tgaagaacat cagtaccggc tacatggtga ctaacgactg      960

caccaatgac agcattacct ggcagctcca ggctgctgtc ctccacgtcc ccgggtgcgt     1020

cccgtgcgag aaagtgggga atgcatctca gtgctggata ccggtctcac cgaatgtggc     1080

cgtgcagcgg cccggcgccc tcacgcaggg cttgcggacg cacatcgaca tggttgtgat     1140

gtccgccacg ctctgctctg ccctctacgt gggggacctc tgcggtgggg tgatgctcgc     1200

agcccaaatg ttcattgtct cgccgcagca ccactggttt gtccaagact gcaattgctc     1260

catctaccct ggtaccatca ctggacaccg catggcatgg gacatgatga tgaactggtc     1320

gcccacggct accatgatct tggcgtacgc gatgcgtgtc cccgaggtca ttatagacat     1380

cattagcggg gctcattggg gcgtcatgtt cggcttggcc tacttctcta tgcagggagc     1440

gtgggcgaaa gtcgttgtca tccttctgtt ggccgccggg gtggacgcgc gcacccatac     1500

tgttgggggt tctgccgcgc agaccaccgg gcgcctcacc agcttatttg acatgggccc     1560

caggcagaaa atccagctcg ttaacaccaa tggcagctgg cacatcaacc gcaccgccct     1620

gaactgcaat gactccttgc acaccggctt tatcgcgtct ctgttctaca cccacagctt     1680

caactcgtca ggatgtcccg aacgcatgtc cgcctgccgc agtatcgagg ccttccgggt     1740

gggatggggc gccttgcaat atgaggataa tgtcaccaat ccagaggata tgagacccta     1800

ttgctggcac tacccaccaa ggcagtgtgg cgtggtctcc gcgaagactg tgtgtggccc     1860

agtgtactgt ttcaccccca gcccagtggt agtgggcacg accgacaggc ttggagcgcc     1920

cacttacacg tggggggaga atgagacaga tgtcttccta ttgaacagca ctcgaccacc     1980

gctggggtca tggttcggct gcacgtggat gaactcttct ggctacacca agacttgcgg     2040

cgcaccaccc tgccgtacta gagctgactt caacgccagc acggacctgt tgtgccccac     2100

ggactgtttt aggaagcatc ctgataccac ttacctcaaa tgcggctctg ggccctggct     2160

cacgccaagg tgcctgatcg actaccccta caggctctgg cattacccct gcacagttaa     2220

ctataccatc ttcaaaataa ggatgtatgt gggaggggtt gagcacaggc tcacggctgc     2280

atgcaatttc actcgtgggg atcgttgcaa cttggaggac agagacagaa gtcaactgtc     2340

tcctttgttg cactccacca cggaatgggc cattttacct tgctcttact cggacctgcc     2400

cgccttgtcg actggtcttc tccacctcca ccaaaacatc gtggacgtac aattcatgta     2460

tggcctatca cctgccctca caaaatacat cgtccgatgg gagtgggtaa tactcttatt     2520

cctgctctta gcggacgcca gggtttgcgc ctgcttatgg atgctcatct tgttgggcca     2580

ggccgaagca gcactagaga agctggtcat cttgcacgct gcgagcgcag ctagctgcaa     2640

tggcttccta tattttgtca tcttttccgt ggctgcttgg tacatcaagg gtcgggtagt     2700

ccccttagct acctattccc tcactggcct gtggtccttt agcctactgc tcctagcatt     2760

gccccaacag gcttatgctt atgacgcatc tgtgcatggc cagataggag cggctctgct     2820

ggtaatgatc actctcttta ctctcacccc cgggtataag acccttctca gccggttttt     2880

gtggtggttg tgctatcttc tgaccctggg ggaagctatg gtccaggagt gggcaccacc     2940

tatgcaggtg cgcggtggcc gtgatggcat catatgggcc gtcgccatat tctacccagg     3000

tgtggtgttt gacataacca agtggctctt ggcggtgctt gggcctgctt acctcctaaa     3060

aggtgctttg acgcgcgtgc cgtacttcgt cagggctcac gctctactga ggatgtgcac     3120

catggcaagg catctcgcgg ggggcaggta cgtccagatg gcgctactag cccttggcag     3180

gtggactggc acttacatct atgaccacct cacccctatg tcggattggg ctgctagtgg     3240

cctgcgggac ctggcggtcg ccgttgagcc tatcatcttc agtccgatgg agaagaaagt     3300

cattgtctgg ggagcggaga cagctgcttg tggggacatt ttacacggac ttcccgtgtc     3360

cgcccgactt ggtcgggagg tcctccttgg cccagctgat ggctatacct ccaaggggtg     3420

gagtcttctc gcccccatca ctgcttacgc ccagcagaca cgtggccttt tgggcaccat     3480

agtggtgagc atgacggggc gcgacaagac agaacaggct ggggaaattc aggtcctgtc     3540

cacagtcact cagtccttcc tcggaacatc catctcgggg gttttgtgga ctgtctacca     3600

tggagctggc aacaagactc tggccggctc acggggtccg gtcacgcaga tgtactccag     3660

tgctgagggg gacttagtag ggtggcccag cccccctggg actaaatctt tggagccgtg     3720

cacgtgtgga gcggtcgacc tgtacctggt cacgcggaac gctgatgtca tcccggctcg     3780

aagacgcggg gacaaacggg gagcgctact ctccccgaga cctctttcca ccttgaaggg     3840

gtcctcagga ggcccggtgc tatgccccag gggccacgct gtcggagtct tccgggcagc     3900

tgtgtgctct cggggcgtgg ctaagtccat agatttcatc cccgttgaga cactcgacat     3960

cgtcacgcgg tcccccacct ttagtgacaa cagcacacca cctgctgtgc cccagaccta     4020

tcaggtcggg tacttgcatg ccccgactgg cagtggaaag agcaccaaag ttcctgtcgc     4080

atatgctgct caggggtata aagtgctagt gcttaatccc tcagtggctg ccaccctggg     4140

gtttggggcg tacttgtcta aggcacatgg catcaatccc aacattagga ctggagtcag     4200

gactgtgacg accggggcgc ccatcacgta ctccacatat ggcaaattcc tcgccgatgg     4260

gggctgtgcg ggcggcgcct acgacatcat catatgtgat gaatgccatg ccgtggactc     4320

taccaccatc cttggcatcg gaacagtcct tgatcaagca gagacagctg gggtcagact     4380

aactgtgctg gctacagcta cgccccctgg gtcagtgaca accccccacc ccaacataga     4440

ggaggtggcc cttgggcagg agggcgagat ccccttctat gggagggcga ttcccctgtc     4500

ttacatcaag ggaggaagac atctgatctt ctgccattca aagaaaaagt gtgacgagct     4560

cgcggcggcc cttcggggta tgggcttgaa ctcagtggca tactacagag ggttggacgt     4620

ctccgtaata ccaactcagg gagacgtagt ggtcgtcgcc accgacgccc tcatgacagg     4680

gtatactggg gactttgact ccgtgatcga ctgcaacgta gcggtcactc aagttgtaga     4740

cctcagttta gaccccacat tcaccataac cacacagatt gtccctcaag acgctgtctc     4800

acgtagccag cgccggggtc gcacgggtag gggaagactg ggcatttata ggtatgtttc     4860

cactggtgag cgagcctcag gaatgtttga cagtgtagtg ctctgtgagt gctacgacgc     4920

aggggccgca tggtatgagc tcacaccatc ggagaccacc gtcaggctca gggcgtattt     4980

caacacgccc ggtttgcctg tgtgccaaga ccatcttgag ttttgggagg cagttttcac     5040

cggcctcaca cacatagatg cccacttcct ttcccaaaca aagcaatcgg gggaaaattt     5100

cgcatactta acagcctacc aggctacagt gtgcgctagg gccaaagccc cccccccgtc     5160

ctgggacgtc atgtggaagt gtttgactcg actcaagccc acactcgtgg gccccacacc     5220

tctcctgtac cgcttgggct ctgttaccaa cgaggtcacc ctcacacatc ccgtgacgaa     5280

atacatcgcc acctgcatgc aagccgacct tgaggtcatg accagcacat gggtcttggc     5340

agggggagtc ttggcggccg tcgccgcgta ttgcctggcg accgggtgtg tttgcatcat     5400

cggccgcttg cacattaacc agcgagccgt cgttgcgccg gacaaggagg tcctctatga     5460

ggcttttgat gagatggagg aatgtgcctc tagggcggct ctcattgaag aggggcagcg     5520

gatagccgag atgctgaagt ccaagatcca aggcttattg cagcaagctt ccaaacaagc     5580

tcaagacata caacccactg tgcaggcttc atggcccaag gtagaacaat tctgggccaa     5640

acacatgtgg aacttcatta gcggcatcca atacctcgca ggactatcaa cactgccagg     5700

gaaccctgca gtagcttcca tgatggcgtt cagtgccgcc ctcaccagtc cgctgtcaac     5760

aagcaccact atccttctca acattttggg gggctggcta gcatcccaaa ttgcaccacc     5820

cgcgggggcc actggcttcg ttgtcagtgg cctagtggga gctgccgtag gcagtatagg     5880

cttaggtaag gtgctagtgg acatcctggc agggtatggt gcgggcattt cgggggctct     5940

cgtcgcattc aagatcatgt ctggcgagaa gccctccatg gaggatgtcg tcaacttgct     6000

gcctggaatt ctgtctccgg gtgccttggt agtgggagtc atctgcgcgg ccattctgcg     6060

ccgacacgtg ggaccggggg aaggcgccgt ccaatggatg aatagactca ttgcctttgc     6120

ttccagagga aatcacgtcg cccccaccca ctacgtgacg gagtcggatg cgtcgcagcg     6180

tgtgacccaa ctacttggct cccttaccat aaccagcctg ctcagaagac tccacaactg     6240

gattactgag gactgcccca tcccatgcgg cggctcgtgg ctccgcgatg tgtgggactg     6300

ggtttgcacc atcctaacag actttaaaaa ttggctgacc tccaaattat tcccaaagat     6360

gcccggcctc ccctttgtct cctgtcaaaa ggggtacaag ggcgtgtggg ccggcactgg     6420

catcatgacc acacggtgtc cttgcggcgc caatatctct ggcaatgtcc gcttgggctc     6480

catgagaatc acggggccta agacctgcat gaatatctgg caggggacct ttcctatcaa     6540

ttgttacacg gagggccagt gcgtgccgaa acccgcgcca aactttaagg tcgccatctg     6600

gagggtggcg gcctcagagt acgcggaggt gacgcagcac gggtcatacc actacataac     6660

aggactcacc actgataact tgaaagtccc ctgccaacta ccctctcccg agttcttttc     6720

ctgggtggac ggagtgcaga tccataggtt tgcccccaca ccgaagccgt ttttccggga     6780

tgaggtctcg ttctgcgttg ggcttaattc atttgtcgtc gggtcccagc ttccttgcga     6840

ccctgaaccc gacacagacg tattgatgtc catgctaaca gatccatctc atatcacggc     6900

ggagactgca gcgcggcgtt tagcgcgggg gtcaccccca tccgaggcaa gctcctcggc     6960

gagccagcta tcggcaccat cgctgcgagc cacctgcacc acccacggca aagcctatga     7020

tgtggacatg gtggatgcta acctgttcat ggggggcgat gtgactcgga tagagtctgg     7080

gtccaaagtg gtcgttctgg actctctcga cccaatggtc gaagaaagga gcgaccttga     7140

gccttcgata ccatcagaat acatgctccc caagaagagg ttcccaccag ctttaccggc     7200

ctgggcacgg cctgattaca acccaccgct tgtggaatcg tggaaaaggc cagattacca     7260

accggccact gttgcgggct gtgctctccc tcctcctagg aaaaccccga cgcctccccc     7320

aaggaggcgc cggacagtgg gcctaagtga ggactccata ggagatgccc ttcaacagct     7380

ggccattaag tcctttggcc agcccccccc aagcggcgat tcaggccttt ccacgggggc     7440

gggcgctgcc gattccggca gtcagacgcc tcctgatgag ttggcccttt cggagacagg     7500

ttccatctct tccatgcccc ccctcgaggg ggagcttgga gatccagacc tggagcctga     7560

gcaggtagag ccccaacccc ccccccaggg gggggtggca gctcccggct cggactcggg     7620

gtcctggtct acttgctccg aggaggacga ctccgtcgtg tgctgctcca tgtcatactc     7680

ctggaccggg gctctaataa ctccttgtag tcccgaagag gagaagttac cgattaaccc     7740

cttgagcaac tccctgttgc gatatcacaa caaggtgtac tgtaccacaa caaagagcgc     7800

ctcactaagg gctaaaaagg taacttttga taggatgcaa gtgctcgact cctactacga     7860

ctcagtctta aaggacatta agctagcggc ctccaaggtc accgcaaggc tcctcaccat     7920

ggaggaggct tgccagttaa ccccacccca ttctgcaaga tctaaatatg ggtttggggc     7980

taaggaggtc cgcagcttgt ccgggagggc cgttaaccac atcaagtccg tgtggaagga     8040

cctcctggag gactcagaaa caccaattcc cacaaccatt atggccaaaa atgaggtgtt     8100

ctgcgtggac cccaccaagg ggggcaagaa agcagctcgc cttatcgttt accctgacct     8160

cggcgtcagg gtctgcgaga agatggccct ttatgacatt acacaaaaac ttcctcaggc     8220

ggtgatgggg gcttcttatg gattccagta ttcccccgct cagcgggtag agtttctctt     8280

gaaagcatgg gcggaaaaga aggaccctat gggtttttcg tatgataccc gatgctttga     8340

ctcaaccgtc actgagagag acatcaggac tgaggagtcc atatatcggg cctgctcctt     8400

gcccgaggag gcccacactg ccatacactc gctaactgag agactttacg tgggagggcc     8460

tatgttcaac agcaagggcc aaacctgcgg gtacaggcgt tgccgcgcca gcggggtgct     8520

caccactagc atggggaaca ccatcacatg ctacgtgaaa gccttagcgg cttgtaaagc     8580

tgcagggata atcgcgccca caatgctggt atgcggcgat gacttggttg tcatctcaga     8640

aagccagggg accgaggagg acgagcggaa cctgagagcc ttcacggagg ctatgaccag     8700

gtattctgcc cctcctggtg acccccccag accggagtat gatctggagc tgataacatc     8760

ttgctcctca aatgtgtctg tggcgttggg cccgcggggc cgccgcagat actacctgac     8820

cagagaccca accactccac tcgcccgggc tgcctgggaa acagttagac actcccctat     8880

caattcatgg ctgggaaaca tcatccagta tgctccaacc atatgggttc gcatggtcct     8940

aatgacacac ttcttctcca ttctcatggt ccaagacacc ctggaccaga acctcaactt     9000

tgagatgtat ggatcagtat actccgtgaa tcctttggac cttccagcca taattgagag     9060

gttacacggg cttgacgcct tttctatgca cacatactct caccacgaac tgacgcgggt     9120

ggcttcagcc ctcagaaaac ttggggcgcc acccctcagg gtgtggaaga gtcgggctcg     9180

cgcagtcagg gcgtccctca tctcccgtgg agggaaagcg gccgtttgcg gccgatatct     9240

cttcaattgg gcggtgaaga ccaagctcaa actcactcca ttgccggagg cgcgcctact     9300

ggacttatcc agttggttca ccgtcggcgc cggcgggggc gacatttttc acagcgtgtc     9360

gcgcgcccga ccccgctcat tactcttcgg cctactccta cttttcgtag gggtaggcct     9420

cttcctactc cccgctcggt agagcggcac acactaggta cactccatag ctaactgttc     9480

cttttttttt tttttttttt tttttttttt tttttttttt ttttcttttt tttttttttc     9540

cctctttctt cccttctcat cttattctac tttctttctt ggtggctcca tcttagccct     9600

agtcacggct agctgtgaaa ggtccgtgag ccgcatgact gcagagagtg ccgtaactgg     9660

tctctctgca gatcatgt                                                   9678


<210>  10
<211>  9678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  10
acccgcccct aataggggcg acactccgcc atgaatcact cccctgtgag gaactactgt       60

cttcacgcag aaagcgtcta gccatggcgt tagtatgagt gtcgtacagc ctccaggccc      120

ccccctcccg ggagagccat agtggtctgc ggaaccggtg agtacaccgg aattgccggg      180

aagactgggt cctttcttgg ataaacccac tctatgcccg gccatttggg cgtgcccccg      240

caagactgct agccgagtag cgttgggttg cgaaaggcct tgtggtactg cctgataggg      300

tgcttgcgag tgccccggga ggtctcgtag accgtgcacc atgagcacaa atcctaaacc      360

tcaaagaaaa accaaaagaa acaccaaccg tcgcccacaa gacgttaagt ttccgggcgg      420

cggccagatc gttggcggag tatacttgtt gccgcgcagg ggccccaggt tgggtgtgcg      480

cgcgacaagg aagacttcgg agcggtccca gccacgtgga aggcgccagc ccatccctaa      540

agatcggcgc tccactggca aatcctgggg aaaaccagga tacccctggc ccctatacgg      600

gaatgaggga ctcggctggg caggatggct cctgtccccc cgaggttccc gtccctcttg      660

gggccccaat gacccccggc ataggtcgcg caacgtgggt aaggtcatcg ataccctaac      720

gtgcggcttt gccgacctca tggggtacat ccctgtcgtg ggcgccccgc tcggcggcgt      780

cgccagagct ctcgcgcatg gcgtgagagt cctggaggac ggggttaatt ttgcaacagg      840

gaacttaccc ggttgctcct tttctatctt cttgctggcc ctgctgtcct gcatcaccac      900

cccggtctcc gctgccgaag tgaagaacat cagtaccggc tacatggtga ctaacgactg      960

caccaatgac agcattacct ggcagctcca ggctgctgtc ctccacgtcc ccgggtgcgt     1020

cccgtgcgag aaagtgggga atgcatctca gtgctggata ccggtctcac cgaatgtggc     1080

cgtgcagcgg cccggcgccc tcacgcaggg cttgcggacg cacatcgaca tggttgtgat     1140

gtccgccacg ctctgctctg ccctctacgt gggggacctc tgcggtgggg tgatgctcgc     1200

agcccaaatg ttcattgtct cgccgcagca ccactggttt gtccaagact gcaattgctc     1260

catctaccct ggtaccatca ctggacaccg catggcatgg gacatgatga tgaactggtc     1320

gcccacggct accatgatct tggcgtacgc gatgcgtgtc cccgaggtca ttatagacat     1380

cattagcggg gctcattggg gcgtcatgtt cggcttggcc tacttctcta tgcagggagc     1440

gtgggcgaaa gtcgttgtca tccttctgtt ggccgccggg gtggacgcgc gcacccatac     1500

tgttgggggt tctgccgcgc agaccaccgg gcgcctcacc agcttatttg acatgggccc     1560

caggcagaaa atccagctcg ttaacaccaa tggcagctgg cacatcaacc gcaccgccct     1620

gaactgcaat gactccttgc acaccggctt tatcgcgtct ctgttctaca cccacagctt     1680

caactcgtca ggatgtcccg aacgcatgtc cgcctgccgc agtatcgagg ccttccgggt     1740

gggatggggc gccttgcaat atgaggataa tgtcaccaat ccagaggata tgagacccta     1800

ttgctggcac tacccaccaa ggcagtgtgg cgtggtctcc gcgaagactg tgtgtggccc     1860

agtgtactgt ttcaccccca gcccagtggt agtgggcacg accgacaggc ttggagcgcc     1920

cacttacacg tggggggaga atgagacaga tgtcttccta ttgaacagca ctcgaccacc     1980

gctggggtca tggttcggct gcacgtggat gaactcttct ggctacacca agacttgcgg     2040

cgcaccaccc tgccgtacta gagctgactt caacgccagc acggacctgt tgtgccccac     2100

ggactgtttt aggaagcatc ctgataccac ttacctcaaa tgcggctctg ggccctggct     2160

cacgccaagg tgcctgatcg actaccccta caggctctgg cattacccct gcacagttaa     2220

ctataccatc ttcaaaataa ggatgtatgt gggaggggtt gagcacaggc tcacggctgc     2280

atgcaatttc actcgtgggg atcgttgcaa cttggaggac agagacagaa gtcaactgtc     2340

tcctttgttg cactccacca cggaatgggc cattttacct tgctcttact cggacctgcc     2400

cgccttgtcg actggtcttc tccacctcca ccaaaacatc gtggacgtac aattcatgta     2460

tggcctatca cctgccctca caaaatacat cgtccgatgg gagtgggtaa tactcttatt     2520

cctgctctta gcggacgcca gggtttgcgc ctgcttatgg atgctcatct tgttgggcca     2580

ggccgaagca gcactagaga agctggtcat cttgcacgct gcgagcgcag ctagctgcaa     2640

tggcttccta tattttgtca tcttttccgt ggctgcttgg tacatcaagg gtcgggtagt     2700

ccccttagct acctattccc tcactggcct gtggtccttt agcctactgc tcctagcatt     2760

gccccaacag gcttatgctt atgacgcatc tgtgcatggc cagataggag cggctctgct     2820

ggtaatgatc actctcttta ctctcacccc cgggtataag acccttctca gccggttttt     2880

gtggtggttg tgctatcttc tgaccctggg ggaagctatg gtccaggagt gggcaccacc     2940

tatgcaggtg cgcggtggcc gtgatggcat catatgggcc gtcgccatat tctacccagg     3000

tgtggtgttt gacataacca agtggctctt ggcggtgctt gggcctgctt acctcctaaa     3060

aggtgctttg acgcgcgtgc cgtacttcgt cagggctcac gctctactga ggatgtgcac     3120

catggcaagg catctcgcgg ggggcaggta cgtccagatg gcgctactag cccttggcag     3180

gtggactggc acttacatct atgaccacct cacccctatg tcggattggg ctgctagtgg     3240

cctgcgggac ctggcggtcg ccgttgagcc tatcatcttc agtccgatgg agaagaaagt     3300

cattgtctgg ggagcggaga cagctgcttg tggggacatt ttacacggac ttcccgtgtc     3360

cgcccgactt ggtcgggagg tcctccttgg cccagctgat ggctatacct ccaaggggtg     3420

gagtcttctc gcccccatca ctgcttacgc ccagcagaca cgtggccttt tgggcaccat     3480

agtggtgagc atgacggggc gcgacaagac agaacaggct ggggaaattc aggtcctgtc     3540

cacagtcact cagtccttcc tcggaacatc catctcgggg gttttgtgga ctgtctacca     3600

tggagctggc aacaagactc tggccggctc acggggtccg gtcacgcaga tgtactccag     3660

tgctgagggg gacttagtag ggtggcccag cccccctggg actaaatctt tggagccgtg     3720

cacgtgtgga gcggtcgacc tgtacctggt cacgcggaac gctgatgtca tcccggctcg     3780

aagacgcggg gacaaacggg gagcgctact ctccccgaga cctctttcca ccttgaaggg     3840

gtcctcagga ggcccggtgc tatgccccag gggccacgct gtcggagtct tccgggcagc     3900

tgtgtgctct cggggcgtgg ctaagtccat agatttcatc cccgttgaga cactcgacat     3960

cgtcacgcgg tcccccacct ttagtgacaa cagcacacca cctgctgtgc cccagaccta     4020

tcaggtcggg tacttgcatg ccccgactgg cagtggaaag agcaccaaag ttcctgtcgc     4080

atatgctgct caggggtata aagtgctagt gcttaatccc tcagtggctg ccaccctggg     4140

gtttggggcg tacttgtcta aggcacatgg catcaatccc aacattagga ctggagtcag     4200

gactgtgacg accggggcgc ccatcacgta ctccacatat ggcaaattcc tcgccgatgg     4260

gggctgtgcg ggcggcgcct acgacatcat catatgtgat gaatgccatg ccgtggactc     4320

taccaccatc cttggcatcg gaacagtcct tgatcaagca gagacagctg gggtcagact     4380

aactgtgctg gctacagcta cgccccctgg gtcagtgaca accccccacc ccaacataga     4440

ggaggtggcc cttgggcagg agggcgagat ccccttctat gggagggcga ttcccctgtc     4500

ttacatcaag ggaggaagac atctgatctt ctgccattca aagaaaaagt gtgacgagct     4560

cgcggcggcc cttcggggta tgggcttgaa ctcagtggca tactacagag ggttggacgt     4620

ctccgtaata ccaactcagg gagacgtagt ggtcgtcgcc accgacgccc tcatgacagg     4680

gtatactggg gactttgact ccgtgatcga ctgcaacgta gcggtcactc aagttgtaga     4740

cttcagttta gaccccacat tcaccataac cacacagatt gtccctcaag acgctgtctc     4800

acgtagccag cgccggggtc gcacgggtag gggaagactg ggcatttata ggtatgtttc     4860

cactggtgag cgagcctcag gaatgtttga cagtgtagtg ctctgtgagt gctacgacgc     4920

aggggccgca tggtatgagc tcacaccatc ggagaccacc gtcaggctca gggcgtattt     4980

caacacgccc ggtttgcctg tgtgccaaga ccatcttgag ttttgggagg cagttttcac     5040

cggcctcaca cacatagatg cccacttcct ttcccaaaca aagcaatcgg gggaaaattt     5100

cgcatactta acagcctacc aggctacagt gtgcgctagg gccaaagccc cccccccgtc     5160

ctgggacgtc atgtggaagt gtttgactcg actcaagccc acactcgtgg gccccacacc     5220

tctcctgtac cgcttgggct ctgttaccaa cgaggtcacc ctcacacatc ccgtgacgaa     5280

atacatcgcc acctgcatgc aagccgacct tgaggtcatg accagcacat gggtcttggc     5340

agggggagtc ttggcggccg tcgcctcgta ttgcctggcg accgggtgtg tttgcatcat     5400

cggccgcttg cacattaacc agcgagccgt cgttgcgccg gacaaggagg tcctctatga     5460

ggcttttgat gagatggagg aatgtgcctc tagggcggct ctcattgaag aggggcagcg     5520

gatagccgag atgctgaagt ccaagatcca aggcttattg cagcaagctt ccaaacaagc     5580

tcaagacata caacccactg tgcaggcttc atggcccaag gtagaacaat tctgggccaa     5640

acacatgtgg aacttcatta gcggcatcca atacctcgca ggactatcaa cactgccagg     5700

gaaccctgca gtagcttcca tgatggcgtt cagtgccgcc ctcaccagtc cgctgtcaac     5760

aagcaccact atccttctca acattttggg gggctggcta gcatcccaaa ttgcaccacc     5820

cgcgggggcc actggcttcg ttgtcagtgg cctagtggga gctgccgtag gcagtatagg     5880

cttaggtaag gtgctagtgg acatcctggc agggtatggt gcgggcattt cgggggctct     5940

cgtcgcattc aagatcatgt ctggcgagaa gccctccatg gaggatgtcg tcaacttgct     6000

gcctggaatt ctgtctccgg gtgccttggt agtgggagtc atctgcgcgg ccattctgcg     6060

ccgacacgtg ggaccggggg aaggcgccgt ccaatggatg aatagactca ttgcctttgc     6120

ttccagagga aatcacgtcg cccccaccca ctacgtgacg gagtcggatg cgtcgcagcg     6180

tgtgacccaa ctacttggct cccttaccat aaccagcctg ctcagaagac tccacaactg     6240

gattactgag gactgcccca tcccatgcgg cggctcgtgg ctccgcgatg tgtgggactg     6300

ggtttgcacc atcctaacag actttaaaaa ttggctgacc tccaaattat tcccaaagat     6360

gcccggcctc ccctttgtct cctgtcaaaa ggggtacaag ggcgtgtggg ccggcactgg     6420

catcatgacc acacggtgtc cttgcggcgc caatatctct ggcaatgtcc gcttgggctc     6480

catgagaatc acggggccta agacctgcat gaatatctgg caggggacct ttcctatcaa     6540

ttgttacacg gagggccagt gcgtgccgaa acccgcgcca aactttaagg tcgccatctg     6600

gagggtggcg gcctcagagt acgcggaggt gacgcagcac gggtcatacc actacataac     6660

aggactcacc actgataact tgaaagtccc ctgccaacta ccctctcccg agttcttttc     6720

ctgggtggac ggagtgcaga tccataggtt tgcccccaca ccgaagccgt ttttccggga     6780

tgaggtctcg ttctgcgttg ggcttaattc atttgtcgtc gggtcccagc ttccttgcga     6840

ccctgaaccc gacacagacg tattgatgtc catgctaaca gatccatctc atatcacggc     6900

ggagactgca gcgcggcgtt tagcgcgggg gtcaccccca tccgaggcaa gctcctcggc     6960

gagccagcta tcggcaccat cgctgcgagc cacctgcacc acccacggca aagcctatga     7020

tgtggacatg gtggatgcta acctgttcat ggggggcgat gtgactcgga tagagtctgg     7080

gtccaaagtg gtcgttctgg actctctcga cccaatggtc gaagaaagga gcgaccttga     7140

gccttcgata ccatcagaat acatgctccc caagaagagg ttcccaccag ctttaccggc     7200

ctgggcacgg cctgattaca acccaccgct tgtggaatcg tggaaaaggc cagattacca     7260

accggccact gttgcgggct gtgctctccc tcctcctagg aaaaccccga cgcctccccc     7320

aaggaggcgc cggacagtgg gcctaagtga ggactccata ggagatgccc ttcaacagct     7380

ggccattaag tcctttggcc agcccccccc aagcggcgat tcaggccttt ccacgggggc     7440

gggcgctgcc gattccggca gtcagacgcc tcctgatgag ttggcccttt cggagacagg     7500

ttccatctct tccatgcccc ccctcgaggg ggagcttgga gatccagacc tggagcctga     7560

gcaggtagag ccccaacccc ccccccaggg gggggtggca gctcccggct cggactcggg     7620

gtcctggtct acttgctccg aggaggacga ctccgtcgtg tgctgctcca tgtcatactc     7680

ctggaccggg gctctaataa ctccttgtag tcccgaagag gagaagttac cgattaaccc     7740

cttgagcaac tccctgttgc gatatcacaa caaggtgtac tgtaccacaa caaagagcgc     7800

ctcactaagg gctaaaaagg taacttttga taggatgcaa gtgctcgact cctactacga     7860

ctcagtctta aaggacatta agctagcggc ctccaaggtc accgcaaggc tcctcaccat     7920

ggaggaggct tgccagttaa ccccacccca ttctgcaaga tctaaatatg ggtttggggc     7980

taaggaggtc cgcagcttgt ccgggagggc cgttaaccac atcaagtccg tgtggaagga     8040

cctcctggag gactcagaaa caccaattcc cacaaccatt atggccaaaa atgaggtgtt     8100

ctgcgtggac cccaccaagg ggggcaagaa agcagctcgc cttatcgttt accctgacct     8160

cggcgtcagg gtctgcgaga agatggccct ttatgacatt acacaaaaac ttcctcaggc     8220

ggtgatgggg gcttcttatg gattccagta ttcccccgct cagcgggtag agtttctctt     8280

gaaagcatgg gcggaaaaga aggaccctat gggtttttcg tatgataccc gatgctttga     8340

ctcaaccgtc actgagagag acatcaggac tgaggagtcc atatatcggg cctgctcctt     8400

gcccgaggag gcccacactg ccatacactc gctaactgag agactttacg tgggagggcc     8460

tatgttcaac agcaagggcc aaacctgcgg gtacaggcgt tgccgcgcca gcggggtgct     8520

caccactagc atggggaaca ccatcacatg ctacgtgaaa gccttagcgg cttgtaaagc     8580

tgcagggata atcgcgccca caatgctggt atgcggcgat gacttggttg tcatctcaga     8640

aagccagggg accgaggagg acgagcggaa cctgagagcc ttcacggagg ctatgaccag     8700

gtattctgcc cctcctggtg acccccccag accggagtat gatctggagc tgataacatc     8760

ttgctcctca aatgtgtctg tggcgttggg cccgcggggc cgccgcagat actacctgac     8820

cagagaccca accactccac tcgcccgggc tgcctgggaa acagttagac actcccctat     8880

caattcatgg ctgggaaaca tcatccagta tgctccaacc atatgggttc gcatggtcct     8940

aatgacacac ttcttctcca ttctcatggt ccaagacacc ctggaccaga acctcaactt     9000

tgagatgtat ggatcagtat actccgtgaa tcctttggac cttccagcca taattgagag     9060

gttacacggg cttgacgcct tttctatgca cacatactct caccacgaac tgacgcgggt     9120

ggcttcagcc ctcagaaaac ttggggcgcc acccctcagg gtgtggaaga gtcgggctcg     9180

cgcagtcagg gcgtccctca tctcccgtgg agggaaagcg gccgtttgcg gccgatatct     9240

cttcaattgg gcggtgaaga ccaagctcaa actcactcca ttgccggagg cgcgcctact     9300

ggacttatcc agttggttca ccgtcggcgc cggcgggggc gacatttttc acagcgtgtc     9360

gcgcgcccga ccccgctcat tactcttcgg cctactccta cttttcgtag gggtaggcct     9420

cttcctactc cccgctcggt agagcggcac acactaggta cactccatag ctaactgttc     9480

cttttttttt tttttttttt tttttttttt tttttttttt ttttcttttt tttttttttc     9540

cctctttctt cccttctcat cttattctac tttctttctt ggtggctcca tcttagccct     9600

agtcacggct agctgtgaaa ggtccgtgag ccgcatgact gcagagagtg ccgtaactgg     9660

tctctctgca gatcatgt                                                   9678


<210>  11
<211>  9678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  11
acccgcccct aataggggcg acactccgcc atgaatcact cccctgtgag gaactactgt       60

cttcacgcag aaagcgtcta gccatggcgt tagtatgagt gtcgtacagc ctccaggccc      120

ccccctcccg ggagagccat agtggtctgc ggaaccggtg agtacaccgg aattgccggg      180

aagactgggt cctttcttgg ataaacccac tctatgcccg gccatttggg cgtgcccccg      240

caagactgct agccgagtag cgttgggttg cgaaaggcct tgtggtactg cctgataggg      300

tgcttgcgag tgccccggga ggtctcgtag accgtgcacc atgagcacaa atcctaaacc      360

tcaaagaaaa accaaaagaa acaccaaccg tcgcccacaa gacgttaagt ttccgggcgg      420

cggccagatc gttggcggag tatacttgtt gccgcgcagg ggccccaggt tgggtgtgcg      480

cgcgacaagg aagacttcgg agcggtccca gccacgtgga aggcgccagc ccatccctaa      540

agatcggcgc tccactggca aatcctgggg aaaaccagga tacccctggc ccctatacgg      600

gaatgaggga ctcggctggg caggatggct cctgtccccc cgaggttccc gtccctcttg      660

gggccccaat gacccccggc ataggtcgcg caacgtgggt aaggtcatcg ataccctaac      720

gtgcggcttt gccgacctca tggggtacat ccctgtcgtg ggcgccccgc tcggcggcgt      780

cgccagagct ctcgcgcatg gcgtgagagt cctggaggac ggggttaatt ttgcaacagg      840

gaacttaccc ggttgctcct tttctatctt cttgctggcc ctgctgtcct gcatcaccac      900

cccggtctcc gctgccgaag tgaagaacat cagtaccggc tacatggtga ctaacgactg      960

caccaatgac agcattacct ggcagctcca ggctgctgtc ctccacgtcc ccgggtgcgt     1020

cccgtgcgag aaagtgggga atgcatctca gtgctggata ccggtctcac cgaatgtggc     1080

cgtgcagcgg cccggcgccc tcacgcaggg cttgcggacg cacatcgaca tggttgtgat     1140

gtccgccacg ctctgctctg ccctctacgt gggggacctc tgcggtgggg tgatgctcgc     1200

agcccaaatg ttcattgtct cgccgcagca ccactggttt gtccaagact gcaattgctc     1260

catctaccct ggtaccatca ctggacaccg catggcatgg gacatgatga tgaactggtc     1320

gcccacggct accatgatct tggcgtacgc gatgcgtgtc cccgaggtca ttatagacat     1380

cattagcggg gctcattggg gcgtcatgtt cggcttggcc tacttctcta tgcagggagc     1440

gtgggcgaaa gtcgttgtca tccttctgtt ggccgccggg gtggacgcgc gcacccatac     1500

tgttgggggt tctgccgcgc agaccaccgg gcgcctcacc agcttatttg acatgggccc     1560

caggcagaaa atccagctcg ttaacaccaa tggcagctgg cacatcaacc gcaccgccct     1620

gaactgcaat gactccttgc acaccggctt tatcgcgtct ctgttctaca cccacagctt     1680

caactcgtca ggatgtcccg aacgcatgtc cgcctgccgc agtatcgagg ccttccgggt     1740

gggatggggc gccttgcaat atgaggataa tgtcaccaat ccagaggata tgagacccta     1800

ttgctggcac tacccaccaa ggcagtgtgg cgtggtctcc gcgaagactg tgtgtggccc     1860

agtgtactgt ttcaccccca gcccagtggt agtgggcacg accgacaggc ttggagcgcc     1920

cacttacacg tggggggaga atgagacaga tgtcttccta ttgaacagca ctcgaccacc     1980

gctggggtca tggttcggct gcacgtggat gaactcttct ggctacacca agacttgcgg     2040

cgcaccaccc tgccgtacta gagctgactt caacgccagc acggacctgt tgtgccccac     2100

ggactgtttt aggaagcatc ctgataccac ttacctcaaa tgcggctctg ggccctggct     2160

cacgccaagg tgcctgatcg actaccccta caggctctgg cattacccct gcacagttaa     2220

ctataccatc ttcaaaataa ggatgtatgt gggaggggtt gagcacaggc tcacggctgc     2280

atgcaatttc actcgtgggg atcgttgcaa cttggaggac agagacagaa gtcaactgtc     2340

tcctttgttg cactccacca cggaatgggc cattttacct tgctcttact cggacctgcc     2400

cgccttgtcg actggtcttc tccacctcca ccaaaacatc gtggacgtac aattcatgta     2460

tggcctatca cctgccctca caaaatacat cgtccgatgg gagtgggtaa tactcttatt     2520

cctgctctta gcggacgcca gggtttgcgc ctgcttatgg atgctcatct tgttgggcca     2580

ggccgaagca gcactagaga agctggtcat cttgcacgct gcgagcgcag ctagctgcaa     2640

tggcttccta tattttgtca tctttttcgt ggctgcttgg tacatcaagg gtcgggtagt     2700

ccccttagct acctattccc tcactggcct gtggtccttt agcctactgc tcctagcatt     2760

gccccaacag gcttatgctt atgacgcatc tgtgcatggc cagataggag cggctctgct     2820

ggtaatgatc actctcttta ctctcacccc cgggtataag acccttctca gccggttttt     2880

gtggtggttg tgctatcttc tgaccctggg ggaagctatg gtccaggagt gggcaccacc     2940

tatgcaggtg cgcggtggcc gtgatggcat catatgggcc gtcgccatat tctacccagg     3000

tgtggtgttt gacataacca agtggctctt ggcggtgctt gggcctgctt acctcctaaa     3060

aggtgctttg acgcgcgtgc cgtacttcgt cagggctcac gctctactga ggatgtgcac     3120

catggcaagg catctcgcgg ggggcaggta cgtccagatg gcgctactag cccttggcag     3180

gtggactggc acttacatct atgaccacct cacccctatg tcggattggg ctgctagtgg     3240

cctgcgggac ctggcggtcg ccgttgagcc tatcatcttc agtccgatgg agaagaaagt     3300

cattgtctgg ggagcggaga cagctgcttg tggggacatt ttacacggac ttcccgtgtc     3360

cgcccgactt ggtcgggagg tcctccttgg cccagctgat ggctatacct ccaaggggtg     3420

gagtcttctc gcccccatca ctgcttacgc ccagcagaca cgtggccttt tgggcaccat     3480

agtggtgagc atgacggggc gcgacaagac agaacaggct ggggaaattc aggtcctgtc     3540

cacagtcact cagtccttcc tcggaacatc catctcgggg gttttgtgga ctgtctacca     3600

tggagctggc aacaagactc tggccggctc acggggtccg gtcacgcaga tgtactccag     3660

tgctgagggg gacttagtag ggtggcccag cccccctggg actaaatctt tggagccgtg     3720

cacgtgtgga gcggtcgacc tgtacctggt cacgcggaac gctgatgtca tcccggctcg     3780

aagacgcggg gacaaacggg gagcgctact ctccccgaga cctctttcca ccttgaaggg     3840

gtcctcagga ggcccggtgc tatgccccag gggccacgct gtcggagtct tccgggcagc     3900

tgtgtgctct cggggcgtgg ctaagtccat agatttcatc cccgttgaga cactcgacat     3960

cgtcacgcgg tcccccacct ttagtgacaa cagcacacca cctgctgtgc cccagaccta     4020

tcaggtcggg tacttgcatg ccccgactgg cagtggaaag agcaccaaag ttcctgtcgc     4080

atatgctgct caggggtata aagtgctagt gcttaatccc tcagtggctg ccaccctggg     4140

gtttggggcg tacttgtcta aggcacatgg catcaatccc aacattagga ctggagtcag     4200

gactgtgacg accggggcgc ccatcacgta ctccacatat ggcaaattcc tcgccgatgg     4260

gggctgtgcg ggcggcgcct acgacatcat catatgtgat gaatgccatg ccgtggactc     4320

taccaccatc cttggcatcg gaacagtcct tgatcaagca gagacagctg gggtcagact     4380

aactgtgctg gctacagcta cgccccctgg gtcagtgaca accccccacc ccaacataga     4440

ggaggtggcc cttgggcagg agggcgagat ccccttctat gggagggcga ttcccctgtc     4500

ttacatcaag ggaggaagac atctgatctt ctgccattca aagaaaaagt gtgacgagct     4560

cgcggcggcc cttcggggta tgggcttgaa ctcagtggca tactacagag ggttggacgt     4620

ctccgtaata ccaactcagg gagacgtagt ggtcgtcgcc accgacgccc tcatgacagg     4680

gtatactggg gactttgact ccgtgatcga ctgcaacgta gcggtcactc aagttgtaga     4740

cctcagttta gaccccacat tcaccataac cacacagatt gtccctcaag acgctgtctc     4800

acgtagccag cgccggggtc gcacgggtag gggaagactg ggcatttata ggtatgtttc     4860

cactggtgag cgagcctcag gaatgtttga cagtgtagtg ctctgtgagt gctacgacgc     4920

aggggccgca tggtatgagc tcacaccatc ggagaccacc gtcaggctca gggcgtattt     4980

caacacgccc ggtttgcctg tgtgccaaga ccatcttgag ttttgggagg cagttttcac     5040

cggcctcaca cacatagatg cccacttcct ttcccaaaca aagcaatcgg gggaaaattt     5100

cgcatactta acagcctacc aggctacagt gtgcgctagg gccaaagccc cccccccgtc     5160

ctgggacgtc atgtggaagt gtttgactcg actcaagccc acactcgtgg gccccacacc     5220

tctcctgtac cgcttgggct ctgttaccaa cgaggtcacc ctcacacatc ccgtgacgaa     5280

atacatcgcc acctgcatgc aagccgacct tgaggtcatg accagcacat gggtcttggc     5340

agggggagtc ttggcggccg tcgcctcgta ttgcctggcg accgggtgtg tttgcatcat     5400

cggccgcttg cacattaacc agcgagccgt cgttgcgccg gacaaggagg tcctctatga     5460

ggcttttgat gagatggagg aatgtgcctc tagggcggct ctcattgaag aggggcagcg     5520

gatagccgag atgctgaagt ccaagatcca aggcttattg cagcaagctt ccaaacaagc     5580

tcaagacata caacccactg tgcaggcttc atggcccaag gtagaacaat tctgggccaa     5640

acacatgtgg aacttcatta gcggcatcca atacctcgca ggactatcaa cactgccagg     5700

gaaccctgca gtagcttcca tgatggcgtt cagtgccgcc ctcaccagtc cgctgtcaac     5760

aagcaccact atccttctca acattttggg gggctggcta gcatcccaaa ttgcaccacc     5820

cgcgggggcc actggcttcg ttgtcagtgg cctagtggga gctgccgtag gcagtatagg     5880

cttaggtaag gtgctagtgg acatcctggc agggtatggt gcgggcattt cgggggctct     5940

cgtcgcattc aagatcatgt ctggcgagaa gccctccatg gaggatgtcg tcaacttgct     6000

gcctggaatt ctgtctccgg gtgccttggt agtgggagtc atctgcgcgg ccattctgcg     6060

ccgacacgtg ggaccggggg aaggcgccgt ccaatggatg aatagactca ttgcctttgc     6120

ttccagagga aatcacgtcg cccccaccca ctacgtgacg gagtcggatg cgtcgcagcg     6180

tgtgacccaa ctacttggct cccttaccat aaccagcctg ctcagaagac tccacaactg     6240

gattactgag gactgcccca tcccatgcgg cggctcgtgg ctccgcgatg tgtgggactg     6300

ggtttgcacc atcctaacag actttaaaaa ttggctgacc tccaaattat tcccaaagat     6360

gcccggcctc ccctttgtct cctgtcaaaa ggggtacaag ggcgtgtggg ccggcactgg     6420

catcatgacc acacggtgtc cttgcggcgc caatatctct ggcaatgtcc gcttgggctc     6480

catgagaatc acggggccta agacctgcat gaatatctgg caggggacct ttcctatcaa     6540

ttgttacacg gagggccagt gcgtgccgaa acccgcgcca aactttaagg tcgccatctg     6600

gagggtggcg gcctcagagt acgcggaggt gacgcagcac gggtcatacc actacataac     6660

aggactcacc actgataact tgaaagtccc ctgccaacta ccctctcccg agttcttttc     6720

ctgggtggac ggagtgcaga tccataggtt tgcccccaca ccgaagccgt ttttccggga     6780

tgaggtctcg ttctgcgttg ggcttaattc atttgtcgtc gggtcccagc ttccttgcga     6840

ccctgaaccc gacacagacg tattgatgtc catgctaaca gatccatctc atatcacggc     6900

ggagactgca gcgcggcgtt tagcgcgggg gtcaccccca tccgaggcaa gctcctcggc     6960

gagccagcta tcggcaccat cgctgcgagc cacctgcacc acccacggca aagcctatga     7020

tgtggacatg gtggatgcta acctgttcat ggggggcgat gtgactcgga tagagtctgg     7080

gtccaaagtg gtcgttctgg actctctcga cccaatggtc gaagaaagga gcgaccttga     7140

gccttcgata ccatcagaat acatgctccc caagaagagg ttcccaccag ctttaccggc     7200

ctgggcacgg cctgattaca acccaccgct tgtggaatcg tggaaaaggc cagattacca     7260

accggccact gttgcgggct gtgctctccc tcctcctagg aaaaccccga cgcctccccc     7320

aaggaggcgc cggacagtgg gcctaagtga ggactccata ggagatgccc ttcaacagct     7380

ggccattaag tcctttggcc agcccccccc aagcggcgat tcaggccttt ccacgggggc     7440

gggcgctgcc gattccggca gtcagacgcc tcctgatgag ttggcccttt cggagacagg     7500

ttccatctct tccatgcccc ccctcgaggg ggagcttgga gatccagacc tggagcctga     7560

gcaggtagag ccccaacccc ccccccaggg gggggtggca gctcccggct cggactcggg     7620

gtcctggtct acttgctccg aggaggacga ctccgtcgtg tgctgctcca tgtcatactc     7680

ctggaccggg gctctaataa ctccttgtag tcccgaagag gagaagttac cgattaaccc     7740

cttgagcaac tccctgttgc gatatcacaa caaggtgtac tgtaccacaa caaagagcgc     7800

ctcactaagg gctaaaaagg taacttttga taggatgcaa gtgctcgact cctactacga     7860

ctcagtctta aaggacatta agctagcggc ctccaaggtc accgcaaggc tcctcaccat     7920

ggaggaggct tgccagttaa ccccacccca ttctgcaaga tctaaatatg ggtttggggc     7980

taaggaggtc cgcagcttgt ccgggagggc cgttaaccac atcaagtccg tgtggaagga     8040

cctcctggag gactcagaaa caccaattcc cacaaccatt atggccaaaa atgaggtgtt     8100

ctgcgtggac cccaccaagg ggggcaagaa agcagctcgc cttatcgttt accctgacct     8160

cggcgtcagg gtctgcgaga agatggccct ttatgacatt acacaaaaac ttcctcaggc     8220

ggtgatgggg gcttcttatg gattccagta ttcccccgct cagcgggtag agtttctctt     8280

gaaagcatgg gcggaaaaga aggaccctat gggtttttcg tatgataccc gatgctttga     8340

ctcaaccgtc actgagagag acatcaggac tgaggagtcc atatatcggg cctgctcctt     8400

gcccgaggag gcccacactg ccatacactc gctaactgag agactttacg tgggagggcc     8460

tatgttcaac agcaagggcc aaacctgcgg gtacaggcgt tgccgcgcca gcggggtgct     8520

caccactagc atggggaaca ccatcacatg ctacgtgaaa gccttagcgg cttgtaaagc     8580

tgcagggata atcgcgccca caatgctggt atgcggcgat gacttggttg tcatctcaga     8640

aagccagggg accgaggagg acgagcggaa cctgagagcc ttcacggagg ctatgaccag     8700

gtattctgcc cctcctggtg acccccccag accggagtat gatctggagc tgataacatc     8760

ttgctcctca aatgtgtctg tggcgttggg cccgcggggc cgccgcagat actacctgac     8820

cagagaccca accactccac tcgcccgggc tgcctgggaa acagttagac actcccctat     8880

caattcatgg ctgggaaaca tcatccagta tgctccaacc atatgggttc gcatggtcct     8940

aatgacacac ttcttctcca ttctcatggt ccaagacacc ctggaccaga acctcaactt     9000

tgagatgtat ggatcagtat actccgtgaa tcctttggac cttccagcca taattgagag     9060

gttacacggg cttgacgcct tttctatgca cacatactct caccacgaac tgacgcgggt     9120

ggcttcagcc ctcagaaaac ttggggcgcc acccctcagg gtgtggaaga gtcgggctcg     9180

cgcagtcagg gcgtccctca tctcccgtgg agggaaagcg gccgtttgcg gccgatatct     9240

cttcaattgg gcggtgaaga ccaagctcaa actcactcca ttgccggagg cgcgcctact     9300

ggacttatcc agttggttca ccgtcggcgc cggcgggggc gacatttttc acagcgtgtc     9360

gcgcgcccga ccccgctcat tactcttcgg cctactccta cttttcgtag gggtaggcct     9420

cttcctactc cccgctcggt agagcggcac acactaggta cactccatag ctaactgttc     9480

cttttttttt tttttttttt tttttttttt tttttttttt ttttcttttt tttttttttc     9540

cctctttctt cccttctcat cttattctac tttctttctt ggtggctcca tcttagccct     9600

agtcacggct agctgtgaaa ggtccgtgag ccgcatgact gcagagagtg ccgtaactgg     9660

tctctctgca gatcatgt                                                   9678


<210>  12
<211>  9678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  12
acccgcccct aataggggcg acactccgcc atgaatcact cccctgtgag gaactactgt       60

cttcacgcag aaagcgtcta gccatggcgt tagtatgagt gtcgtacagc ctccaggccc      120

ccccctcccg ggagagccat agtggtctgc ggaaccggtg agtacaccgg aattgccggg      180

aagactgggt cctttcttgg ataaacccac tctatgcccg gccatttggg cgtgcccccg      240

caagactgct agccgagtag cgttgggttg cgaaaggcct tgtggtactg cctgataggg      300

tgcttgcgag tgccccggga ggtctcgtag accgtgcacc atgagcacaa atcctaaacc      360

tcaaagaaaa accaaaagaa acaccaaccg tcgcccacaa gacgttaagt ttccgggcgg      420

cggccagatc gttggcggag tatacttgtt gccgcgcagg ggccccaggt tgggtgtgcg      480

cgcgacaagg aagacttcgg agcggtccca gccacgtgga aggcgccagc ccatccctaa      540

agatcggcgc tccactggca aatcctgggg aaaaccagga tacccctggc ccctatacgg      600

gaatgaggga ctcggctggg caggatggct cctgtccccc cgaggttccc gtccctcttg      660

gggccccaat gacccccggc ataggtcgcg caacgtgggt aaggtcatcg ataccctaac      720

gtgcggcttt gccgacctca tggggtacat ccctgtcgtg ggcgccccgc tcggcggcgt      780

cgccagagct ctcgcgcatg gcgtgagagt cctggaggac ggggttaatt ttgcaacagg      840

gaacttaccc ggttgctcct tttctatctt cttgctggcc ctgctgtcct gcatcaccac      900

cccggtctcc gctgccgaag tgaagaacat cagtaccggc tacatggtga ctaacgactg      960

caccaatgac agcattacct ggcagctcca ggctgctgtc ctccacgtcc ccgggtgcgt     1020

cccgtgcgag aaagtgggga atgcatctca gtgctggata ccggtctcac cgaatgtggc     1080

cgtgcagcgg cccggcgccc tcacgcaggg cttgcggacg cacatcgaca tggttgtgat     1140

gtccgccacg ctctgctctg ccctctacgt gggggacctc tgcggtgggg tgatgctcgc     1200

agcccaaatg ttcattgtct cgccgcagca ccactggttt gtccaagact gcaattgctc     1260

catctaccct ggtaccatca ctggacaccg catggcatgg gacatgatga tgaactggtc     1320

gcccacggct accatgatct tggcgtacgc gatgcgtgtc cccgaggtca ttatagacat     1380

cattagcggg gctcattggg gcgtcatgtt cggcttggcc tacttctcta tgcagggagc     1440

gtgggcgaaa gtcgttgtca tccttctgtt ggccgccggg gtggacgcgc gcacccatac     1500

tgttgggggt tctgccgcgc agaccaccgg gcgcctcacc agcttatttg acatgggccc     1560

caggcagaaa atccagctcg ttaacaccaa tggcagctgg cacatcaacc gcaccgccct     1620

gaactgcaat gactccttgc acaccggctt tatcgcgtct ctgttctaca cccacagctt     1680

caactcgtca ggatgtcccg aacgcatgtc cgcctgccgc agtatcgagg ccttccgggt     1740

gggatggggc gccttgcaat atgaggataa tgtcaccaat ccagaggata tgagacccta     1800

ttgctggcac tacccaccaa ggcagtgtgg cgtggtctcc gcgaagactg tgtgtggccc     1860

agtgtactgt ttcaccccca gcccagtggt agtgggcacg accgacaggc ttggagcgcc     1920

cacttacacg tggggggaga atgagacaga tgtcttccta ttgaacagca ctcgaccacc     1980

gctggggtca tggttcggct gcacgtggat gaactcttct ggctacacca agacttgcgg     2040

cgcaccaccc tgccgtacta gagctgactt caacgccagc acggacctgt tgtgccccac     2100

ggactgtttt aggaagcatc ctgataccac ttacctcaaa tgcggctctg ggccctggct     2160

cacgccaagg tgcctgatcg actaccccta caggctctgg cattacccct gcacagttaa     2220

ctataccatc ttcaaaataa ggatgtatgt gggaggggtt gagcacaggc tcacggctgc     2280

atgcaatttc actcgtgggg atcgttgcaa cttggaggac agagacagaa gtcaactgtc     2340

tcctttgttg cactccacca cggaatgggc cattttacct tgctcttact cggacctgcc     2400

cgccttgtcg actggtcttc tccacctcca ccaaaacatc gtggacgtac aattcatgta     2460

tggcctatca cctgccctca caaaatacat cgtccgatgg gagtgggtaa tactcttatt     2520

cctgctctta gcggacgcca gggtttgcgc ctgcttatgg atgctcatct tgttgggcca     2580

ggccgaagca gcactagaga agctggtcat cttgcacgct gcgagcgcag ctagctgcaa     2640

tggcttccta tattttgtca tcttttccgt ggctgcttgg tacatcaagg gtcgggtagt     2700

ccccttagct acctattccc tcactggcct gtggtccttt agcctactgc tcctagcatt     2760

gccccaacag gcttatgctt atgacgcatc tgtgcatggc cagataggag cggctctgct     2820

ggtaatgatc actctcttta ctctcacccc cgggtataag acccttctca gccggttttt     2880

gtggtggttg tgctatcttc tgaccctggg ggaagctatg gtccaggagt gggcaccacc     2940

tatgcaggtg cgcggtggcc gtgatggcat catatgggcc gtcgccatat tctacccagg     3000

tgtggtgttt gacataacca agtggctctt ggcggtgctt gggcctgctt acctcctaaa     3060

aggtgctttg acgcgcgtgc cgtacttcgt cagggctcac gctctactga ggatgtgcac     3120

catggcaagg catctcgcgg ggggcaggta cgtccagatg gcgctactag cccttggcag     3180

gtggactggc acttacatct atgaccacct cacccctatg tcggattggg ctgctagtgg     3240

cctgcgggac ctggcggtcg ccgttgagcc tatcatcttc agtccgatgg agaagaaagt     3300

cattgtctgg ggagcggaga cagctgcttg tggggacatt ttacacggac ttcccgtgtc     3360

cgcccgactt ggtcgggagg tcctccttgg cccagctgat ggctatacct ccaaggggtg     3420

gagtcttctc gcccccatca ctgcttacgc ccagcagaca cgtggccttt tgggcaccat     3480

agtggtgagc atgacggggc gcgacaagac agaacaggct ggggaaattc aggtcctgtc     3540

cacagtcact cagtccttcc tcggaacatc catctcgggg gttttgtgga ctgtctacca     3600

tggagctggc aacaagactc tggccggctc acggggtccg gtcacgcaga tgtactccag     3660

tgctgagggg gacttagtag ggtggcccag cccccctggg actaaatctt tggagccgtg     3720

cacgtgtgga gcggtcgacc tgtacctggt cacgcggaac gctgatgtca tcccggctcg     3780

aagacgcggg gacaaacggg gagcgctact ctccccgaga cctctttcca ccttgaaggg     3840

gtcctcagga ggcccggtgc tatgccccag gggccacgct gtcggagtct tccgggcagc     3900

tgtgtgctct cggggcgtgg ctaagtccat agatttcatc cccgttgaga cactcgacat     3960

cgtcacgcgg tcccccacct ttagtgacaa cagcacacca cctgctgtgc cccagaccta     4020

tcaggtcggg tacttgcatg ccccgactgg cagtggaaag agcaccaaag ttcctgtcgc     4080

atatgctgct caggggtata aagtgctagt gcttaatccc tcagtggctg ccaccctggg     4140

gtttggggcg tacttgtcta aggcacatgg catcaatccc aacattagga ctggagtcag     4200

gactgtgacg accggggcgc ccatcacgta ctccacatat ggcaaattcc tcgccgatgg     4260

gggctgtgcg ggcggcgcct acgacatcat catatgtgat gaatgccatg ccgtggactc     4320

taccaccatc cttggcatcg gaacagtcct tgatcaagca gagacagctg gggtcagact     4380

aactgtgctg gctacagcta cgccccctgg gtcagtgaca accccccacc ccaacataga     4440

ggaggtggcc cttgggcagg agggcgagat ccccttctat gggagggcga ttcccctgtc     4500

ttacatcaag ggaggaagac atctgatctt ctgccattca aagaaaaagt gtgacgagct     4560

cgcggcggcc cttcggggta tgggcttgaa ctcagtggca tactacagag ggttggacgt     4620

ctccgtaata ccaactcagg gagacgtagt ggtcgtcgcc accgacgccc tcatgacagg     4680

gtatactggg gactttgact ccgtgatcga ctgcaacgta gcggtcactc aagttgtaga     4740

cttcagttta gaccccacat tcaccataac cacacagatt gtccctcaag acgctgtctc     4800

acgtagccag cgccggggtc gcacgggtag gggaagactg ggcatttata ggtatgtttc     4860

cactggtgag cgagcctcag gaatgtttga cagtgtagtg ctctgtgagt gctacgacgc     4920

aggggccgca tggtatgagc tcacaccatc ggagaccacc gtcaggctca gggcgtattt     4980

caacacgccc ggtttgcctg tgtgccaaga ccatcttgag ttttgggagg cagttttcac     5040

cggcctcaca cacatagatg cccacttcct ttcccaaaca aagcaatcgg gggaaaattt     5100

cgcatactta acagcctacc aggctacagt gtgcgctagg gccaaagccc cccccccgtc     5160

ctgggacgtc atgtggaagt gtttgactcg actcaagccc acactcgtgg gccccacacc     5220

tctcctgtac cgcttgggct ctgttaccaa cgaggtcacc ctcacacatc ccgtgacgaa     5280

atacatcgcc acctgcatgc aagccgacct tgaggtcatg accagcacat gggtcttggc     5340

agggggagtc ttggcggccg tcgccgcgta ttgcctggcg accgggtgtg tttgcatcat     5400

cggccgcttg cacattaacc agcgagccgt cgttgcgccg gacaaggagg tcctctatga     5460

ggcttttgat gagatggagg aatgtgcctc tagggcggct ctcattgaag aggggcagcg     5520

gatagccgag atgctgaagt ccaagatcca aggcttattg cagcaagctt ccaaacaagc     5580

tcaagacata caacccactg tgcaggcttc atggcccaag gtagaacaat tctgggccaa     5640

acacatgtgg aacttcatta gcggcatcca atacctcgca ggactatcaa cactgccagg     5700

gaaccctgca gtagcttcca tgatggcgtt cagtgccgcc ctcaccagtc cgctgtcaac     5760

aagcaccact atccttctca acattttggg gggctggcta gcatcccaaa ttgcaccacc     5820

cgcgggggcc actggcttcg ttgtcagtgg cctagtggga gctgccgtag gcagtatagg     5880

cttaggtaag gtgctagtgg acatcctggc agggtatggt gcgggcattt cgggggctct     5940

cgtcgcattc aagatcatgt ctggcgagaa gccctccatg gaggatgtcg tcaacttgct     6000

gcctggaatt ctgtctccgg gtgccttggt agtgggagtc atctgcgcgg ccattctgcg     6060

ccgacacgtg ggaccggggg aaggcgccgt ccaatggatg aatagactca ttgcctttgc     6120

ttccagagga aatcacgtcg cccccaccca ctacgtgacg gagtcggatg cgtcgcagcg     6180

tgtgacccaa ctacttggct cccttaccat aaccagcctg ctcagaagac tccacaactg     6240

gattactgag gactgcccca tcccatgcgg cggctcgtgg ctccgcgatg tgtgggactg     6300

ggtttgcacc atcctaacag actttaaaaa ttggctgacc tccaaattat tcccaaagat     6360

gcccggcctc ccctttgtct cctgtcaaaa ggggtacaag ggcgtgtggg ccggcactgg     6420

catcatgacc acacggtgtc cttgcggcgc caatatctct ggcaatgtcc gcttgggctc     6480

catgagaatc acggggccta agacctgcat gaatatctgg caggggacct ttcctatcaa     6540

ttgttacacg gagggccagt gcgtgccgaa acccgcgcca aactttaagg tcgccatctg     6600

gagggtggcg gcctcagagt acgcggaggt gacgcagcac gggtcatacc actacataac     6660

aggactcacc actgataact tgaaagtccc ctgccaacta ccctctcccg agttcttttc     6720

ctgggtggac ggagtgcaga tccataggtt tgcccccaca ccgaagccgt ttttccggga     6780

tgaggtctcg ttctgcgttg ggcttaattc atttgtcgtc gggtcccagc ttccttgcga     6840

ccctgaaccc gacacagacg tattgatgtc catgctaaca gatccatctc atatcacggc     6900

ggagactgca gcgcggcgtt tagcgcgggg gtcaccccca tccgaggcaa gctcctcggc     6960

gagccagcta tcggcaccat cgctgcgagc cacctgcacc acccacggca aagcctatga     7020

tgtggacatg gtggatgcta acctgttcat ggggggcgat gtgactcgga tagagtctgg     7080

gtccaaagtg gtcgttctgg actctctcga cccaatggtc gaagaaagga gcgaccttga     7140

gccttcgata ccatcagaat acatgctccc caagaagagg ttcccaccag ctttaccggc     7200

ctgggcacgg cctgattaca acccaccgct tgtggaatcg tggaaaaggc cagattacca     7260

accggccact gttgcgggct gtgctctccc tcctcctagg aaaaccccga cgcctccccc     7320

aaggaggcgc cggacagtgg gcctaagtga ggactccata ggagatgccc ttcaacagct     7380

ggccattaag tcctttggcc agcccccccc aagcggcgat tcaggccttt ccacgggggc     7440

gggcgctgcc gattccggca gtcagacgcc tcctgatgag ttggcccttt cggagacagg     7500

ttccatctct tccatgcccc ccctcgaggg ggagcttgga gatccagacc tggagcctga     7560

gcaggtagag ccccaacccc ccccccaggg gggggtggca gctcccggct cggactcggg     7620

gtcctggtct acttgctccg aggaggacga ctccgtcgtg tgctgctcca tgtcatactc     7680

ctggaccggg gctctaataa ctccttgtag tcccgaagag gagaagttac cgattaaccc     7740

cttgagcaac tccctgttgc gatatcacaa caaggtgtac tgtaccacaa caaagagcgc     7800

ctcactaagg gctaaaaagg taacttttga taggatgcaa gtgctcgact cctactacga     7860

ctcagtctta aaggacatta agctagcggc ctccaaggtc accgcaaggc tcctcaccat     7920

ggaggaggct tgccagttaa ccccacccca ttctgcaaga tctaaatatg ggtttggggc     7980

taaggaggtc cgcagcttgt ccgggagggc cgttaaccac atcaagtccg tgtggaagga     8040

cctcctggag gactcagaaa caccaattcc cacaaccatt atggccaaaa atgaggtgtt     8100

ctgcgtggac cccaccaagg ggggcaagaa agcagctcgc cttatcgttt accctgacct     8160

cggcgtcagg gtctgcgaga agatggccct ttatgacatt acacaaaaac ttcctcaggc     8220

ggtgatgggg gcttcttatg gattccagta ttcccccgct cagcgggtag agtttctctt     8280

gaaagcatgg gcggaaaaga aggaccctat gggtttttcg tatgataccc gatgctttga     8340

ctcaaccgtc actgagagag acatcaggac tgaggagtcc atatatcggg cctgctcctt     8400

gcccgaggag gcccacactg ccatacactc gctaactgag agactttacg tgggagggcc     8460

tatgttcaac agcaagggcc aaacctgcgg gtacaggcgt tgccgcgcca gcggggtgct     8520

caccactagc atggggaaca ccatcacatg ctacgtgaaa gccttagcgg cttgtaaagc     8580

tgcagggata atcgcgccca caatgctggt atgcggcgat gacttggttg tcatctcaga     8640

aagccagggg accgaggagg acgagcggaa cctgagagcc ttcacggagg ctatgaccag     8700

gtattctgcc cctcctggtg acccccccag accggagtat gatctggagc tgataacatc     8760

ttgctcctca aatgtgtctg tggcgttggg cccgcggggc cgccgcagat actacctgac     8820

cagagaccca accactccac tcgcccgggc tgcctgggaa acagttagac actcccctat     8880

caattcatgg ctgggaaaca tcatccagta tgctccaacc atatgggttc gcatggtcct     8940

aatgacacac ttcttctcca ttctcatggt ccaagacacc ctggaccaga acctcaactt     9000

tgagatgtat ggatcagtat actccgtgaa tcctttggac cttccagcca taattgagag     9060

gttacacggg cttgacgcct tttctatgca cacatactct caccacgaac tgacgcgggt     9120

ggcttcagcc ctcagaaaac ttggggcgcc acccctcagg gtgtggaaga gtcgggctcg     9180

cgcagtcagg gcgtccctca tctcccgtgg agggaaagcg gccgtttgcg gccgatatct     9240

cttcaattgg gcggtgaaga ccaagctcaa actcactcca ttgccggagg cgcgcctact     9300

ggacttatcc agttggttca ccgtcggcgc cggcgggggc gacatttttc acagcgtgtc     9360

gcgcgcccga ccccgctcat tactcttcgg cctactccta cttttcgtag gggtaggcct     9420

cttcctactc cccgctcggt agagcggcac acactaggta cactccatag ctaactgttc     9480

cttttttttt tttttttttt tttttttttt tttttttttt ttttcttttt tttttttttc     9540

cctctttctt cccttctcat cttattctac tttctttctt ggtggctcca tcttagccct     9600

agtcacggct agctgtgaaa ggtccgtgag ccgcatgact gcagagagtg ccgtaactgg     9660

tctctctgca gatcatgt                                                   9678


<210>  13
<211>  9678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  13
acccgcccct aataggggcg acactccgcc atgaatcact cccctgtgag gaactactgt       60

cttcacgcag aaagcgtcta gccatggcgt tagtatgagt gtcgtacagc ctccaggccc      120

ccccctcccg ggagagccat agtggtctgc ggaaccggtg agtacaccgg aattgccggg      180

aagactgggt cctttcttgg ataaacccac tctatgcccg gccatttggg cgtgcccccg      240

caagactgct agccgagtag cgttgggttg cgaaaggcct tgtggtactg cctgataggg      300

tgcttgcgag tgccccggga ggtctcgtag accgtgcacc atgagcacaa atcctaaacc      360

tcaaagaaaa accaaaagaa acaccaaccg tcgcccacaa gacgttaagt ttccgggcgg      420

cggccagatc gttggcggag tatacttgtt gccgcgcagg ggccccaggt tgggtgtgcg      480

cgcgacaagg aagacttcgg agcggtccca gccacgtgga aggcgccagc ccatccctaa      540

agatcggcgc tccactggca aatcctgggg aaaaccagga tacccctggc ccctatacgg      600

gaatgaggga ctcggctggg caggatggct cctgtccccc cgaggttccc gtccctcttg      660

gggccccaat gacccccggc ataggtcgcg caacgtgggt aaggtcatcg ataccctaac      720

gtgcggcttt gccgacctca tggggtacat ccctgtcgtg ggcgccccgc tcggcggcgt      780

cgccagagct ctcgcgcatg gcgtgagagt cctggaggac ggggttaatt ttgcaacagg      840

gaacttaccc ggttgctcct tttctatctt cttgctggcc ctgctgtcct gcatcaccac      900

cccggtctcc gctgccgaag tgaagaacat cagtaccggc tacatggtga ctaacgactg      960

caccaatgac agcattacct ggcagctcca ggctgctgtc ctccacgtcc ccgggtgcgt     1020

cccgtgcgag aaagtgggga atgcatctca gtgctggata ccggtctcac cgaatgtggc     1080

cgtgcagcgg cccggcgccc tcacgcaggg cttgcggacg cacatcgaca tggttgtgat     1140

gtccgccacg ctctgctctg ccctctacgt gggggacctc tgcggtgggg tgatgctcgc     1200

agcccaaatg ttcattgtct cgccgcagca ccactggttt gtccaagact gcaattgctc     1260

catctaccct ggtaccatca ctggacaccg catggcatgg gacatgatga tgaactggtc     1320

gcccacggct accatgatct tggcgtacgc gatgcgtgtc cccgaggtca ttatagacat     1380

cattagcggg gctcattggg gcgtcatgtt cggcttggcc tacttctcta tgcagggagc     1440

gtgggcgaaa gtcgttgtca tccttctgtt ggccgccggg gtggacgcgc gcacccatac     1500

tgttgggggt tctgccgcgc agaccaccgg gcgcctcacc agcttatttg acatgggccc     1560

caggcagaaa atccagctcg ttaacaccaa tggcagctgg cacatcaacc gcaccgccct     1620

gaactgcaat gactccttgc acaccggctt tatcgcgtct ctgttctaca cccacagctt     1680

caactcgtca ggatgtcccg aacgcatgtc cgcctgccgc agtatcgagg ccttccgggt     1740

gggatggggc gccttgcaat atgaggataa tgtcaccaat ccagaggata tgagacccta     1800

ttgctggcac tacccaccaa ggcagtgtgg cgtggtctcc gcgaagactg tgtgtggccc     1860

agtgtactgt ttcaccccca gcccagtggt agtgggcacg accgacaggc ttggagcgcc     1920

cacttacacg tggggggaga atgagacaga tgtcttccta ttgaacagca ctcgaccacc     1980

gctggggtca tggttcggct gcacgtggat gaactcttct ggctacacca agacttgcgg     2040

cgcaccaccc tgccgtacta gagctgactt caacgccagc acggacctgt tgtgccccac     2100

ggactgtttt aggaagcatc ctgataccac ttacctcaaa tgcggctctg ggccctggct     2160

cacgccaagg tgcctgatcg actaccccta caggctctgg cattacccct gcacagttaa     2220

ctataccatc ttcaaaataa ggatgtatgt gggaggggtt gagcacaggc tcacggctgc     2280

atgcaatttc actcgtgggg atcgttgcaa cttggaggac agagacagaa gtcaactgtc     2340

tcctttgttg cactccacca cggaatgggc cattttacct tgctcttact cggacctgcc     2400

cgccttgtcg actggtcttc tccacctcca ccaaaacatc gtggacgtac aattcatgta     2460

tggcctatca cctgccctca caaaatacat cgtccgatgg gagtgggtaa tactcttatt     2520

cctgctctta gcggacgcca gggtttgcgc ctgcttatgg atgctcatct tgttgggcca     2580

ggccgaagca gcactagaga agctggtcat cttgcacgct gcgagcgcag ctagctgcaa     2640

tggcttccta tattttgtca tctttttcgt ggctgcttgg tacatcaagg gtcgggtagt     2700

ccccttagct acctattccc tcactggcct gtggtccttt agcctactgc tcctagcatt     2760

gccccaacag gcttatgctt atgacgcatc tgtgcatggc cagataggag cggctctgct     2820

ggtaatgatc actctcttta ctctcacccc cgggtataag acccttctca gccggttttt     2880

gtggtggttg tgctatcttc tgaccctggg ggaagctatg gtccaggagt gggcaccacc     2940

tatgcaggtg cgcggtggcc gtgatggcat catatgggcc gtcgccatat tctacccagg     3000

tgtggtgttt gacataacca agtggctctt ggcggtgctt gggcctgctt acctcctaaa     3060

aggtgctttg acgcgcgtgc cgtacttcgt cagggctcac gctctactga ggatgtgcac     3120

catggcaagg catctcgcgg ggggcaggta cgtccagatg gcgctactag cccttggcag     3180

gtggactggc acttacatct atgaccacct cacccctatg tcggattggg ctgctagtgg     3240

cctgcgggac ctggcggtcg ccgttgagcc tatcatcttc agtccgatgg agaagaaagt     3300

cattgtctgg ggagcggaga cagctgcttg tggggacatt ttacacggac ttcccgtgtc     3360

cgcccgactt ggtcgggagg tcctccttgg cccagctgat ggctatacct ccaaggggtg     3420

gagtcttctc gcccccatca ctgcttacgc ccagcagaca cgtggccttt tgggcaccat     3480

agtggtgagc atgacggggc gcgacaagac agaacaggct ggggaaattc aggtcctgtc     3540

cacagtcact cagtccttcc tcggaacatc catctcgggg gttttgtgga ctgtctacca     3600

tggagctggc aacaagactc tggccggctc acggggtccg gtcacgcaga tgtactccag     3660

tgctgagggg gacttagtag ggtggcccag cccccctggg actaaatctt tggagccgtg     3720

cacgtgtgga gcggtcgacc tgtacctggt cacgcggaac gctgatgtca tcccggctcg     3780

aagacgcggg gacaaacggg gagcgctact ctccccgaga cctctttcca ccttgaaggg     3840

gtcctcagga ggcccggtgc tatgccccag gggccacgct gtcggagtct tccgggcagc     3900

tgtgtgctct cggggcgtgg ctaagtccat agatttcatc cccgttgaga cactcgacat     3960

cgtcacgcgg tcccccacct ttagtgacaa cagcacacca cctgctgtgc cccagaccta     4020

tcaggtcggg tacttgcatg ccccgactgg cagtggaaag agcaccaaag ttcctgtcgc     4080

atatgctgct caggggtata aagtgctagt gcttaatccc tcagtggctg ccaccctggg     4140

gtttggggcg tacttgtcta aggcacatgg catcaatccc aacattagga ctggagtcag     4200

gactgtgacg accggggcgc ccatcacgta ctccacatat ggcaaattcc tcgccgatgg     4260

gggctgtgcg ggcggcgcct acgacatcat catatgtgat gaatgccatg ccgtggactc     4320

taccaccatc cttggcatcg gaacagtcct tgatcaagca gagacagctg gggtcagact     4380

aactgtgctg gctacagcta cgccccctgg gtcagtgaca accccccacc ccaacataga     4440

ggaggtggcc cttgggcagg agggcgagat ccccttctat gggagggcga ttcccctgtc     4500

ttacatcaag ggaggaagac atctgatctt ctgccattca aagaaaaagt gtgacgagct     4560

cgcggcggcc cttcggggta tgggcttgaa ctcagtggca tactacagag ggttggacgt     4620

ctccgtaata ccaactcagg gagacgtagt ggtcgtcgcc accgacgccc tcatgacagg     4680

gtatactggg gactttgact ccgtgatcga ctgcaacgta gcggtcactc aagttgtaga     4740

cctcagttta gaccccacat tcaccataac cacacagatt gtccctcaag acgctgtctc     4800

acgtagccag cgccggggtc gcacgggtag gggaagactg ggcatttata ggtatgtttc     4860

cactggtgag cgagcctcag gaatgtttga cagtgtagtg ctctgtgagt gctacgacgc     4920

aggggccgca tggtatgagc tcacaccatc ggagaccacc gtcaggctca gggcgtattt     4980

caacacgccc ggtttgcctg tgtgccaaga ccatcttgag ttttgggagg cagttttcac     5040

cggcctcaca cacatagatg cccacttcct ttcccaaaca aagcaatcgg gggaaaattt     5100

cgcatactta acagcctacc aggctacagt gtgcgctagg gccaaagccc cccccccgtc     5160

ctgggacgtc atgtggaagt gtttgactcg actcaagccc acactcgtgg gccccacacc     5220

tctcctgtac cgcttgggct ctgttaccaa cgaggtcacc ctcacacatc ccgtgacgaa     5280

atacatcgcc acctgcatgc aagccgacct tgaggtcatg accagcacat gggtcttggc     5340

agggggagtc ttggcggccg tcgccgcgta ttgcctggcg accgggtgtg tttgcatcat     5400

cggccgcttg cacattaacc agcgagccgt cgttgcgccg gacaaggagg tcctctatga     5460

ggcttttgat gagatggagg aatgtgcctc tagggcggct ctcattgaag aggggcagcg     5520

gatagccgag atgctgaagt ccaagatcca aggcttattg cagcaagctt ccaaacaagc     5580

tcaagacata caacccactg tgcaggcttc atggcccaag gtagaacaat tctgggccaa     5640

acacatgtgg aacttcatta gcggcatcca atacctcgca ggactatcaa cactgccagg     5700

gaaccctgca gtagcttcca tgatggcgtt cagtgccgcc ctcaccagtc cgctgtcaac     5760

aagcaccact atccttctca acattttggg gggctggcta gcatcccaaa ttgcaccacc     5820

cgcgggggcc actggcttcg ttgtcagtgg cctagtggga gctgccgtag gcagtatagg     5880

cttaggtaag gtgctagtgg acatcctggc agggtatggt gcgggcattt cgggggctct     5940

cgtcgcattc aagatcatgt ctggcgagaa gccctccatg gaggatgtcg tcaacttgct     6000

gcctggaatt ctgtctccgg gtgccttggt agtgggagtc atctgcgcgg ccattctgcg     6060

ccgacacgtg ggaccggggg aaggcgccgt ccaatggatg aatagactca ttgcctttgc     6120

ttccagagga aatcacgtcg cccccaccca ctacgtgacg gagtcggatg cgtcgcagcg     6180

tgtgacccaa ctacttggct cccttaccat aaccagcctg ctcagaagac tccacaactg     6240

gattactgag gactgcccca tcccatgcgg cggctcgtgg ctccgcgatg tgtgggactg     6300

ggtttgcacc atcctaacag actttaaaaa ttggctgacc tccaaattat tcccaaagat     6360

gcccggcctc ccctttgtct cctgtcaaaa ggggtacaag ggcgtgtggg ccggcactgg     6420

catcatgacc acacggtgtc cttgcggcgc caatatctct ggcaatgtcc gcttgggctc     6480

catgagaatc acggggccta agacctgcat gaatatctgg caggggacct ttcctatcaa     6540

ttgttacacg gagggccagt gcgtgccgaa acccgcgcca aactttaagg tcgccatctg     6600

gagggtggcg gcctcagagt acgcggaggt gacgcagcac gggtcatacc actacataac     6660

aggactcacc actgataact tgaaagtccc ctgccaacta ccctctcccg agttcttttc     6720

ctgggtggac ggagtgcaga tccataggtt tgcccccaca ccgaagccgt ttttccggga     6780

tgaggtctcg ttctgcgttg ggcttaattc atttgtcgtc gggtcccagc ttccttgcga     6840

ccctgaaccc gacacagacg tattgatgtc catgctaaca gatccatctc atatcacggc     6900

ggagactgca gcgcggcgtt tagcgcgggg gtcaccccca tccgaggcaa gctcctcggc     6960

gagccagcta tcggcaccat cgctgcgagc cacctgcacc acccacggca aagcctatga     7020

tgtggacatg gtggatgcta acctgttcat ggggggcgat gtgactcgga tagagtctgg     7080

gtccaaagtg gtcgttctgg actctctcga cccaatggtc gaagaaagga gcgaccttga     7140

gccttcgata ccatcagaat acatgctccc caagaagagg ttcccaccag ctttaccggc     7200

ctgggcacgg cctgattaca acccaccgct tgtggaatcg tggaaaaggc cagattacca     7260

accggccact gttgcgggct gtgctctccc tcctcctagg aaaaccccga cgcctccccc     7320

aaggaggcgc cggacagtgg gcctaagtga ggactccata ggagatgccc ttcaacagct     7380

ggccattaag tcctttggcc agcccccccc aagcggcgat tcaggccttt ccacgggggc     7440

gggcgctgcc gattccggca gtcagacgcc tcctgatgag ttggcccttt cggagacagg     7500

ttccatctct tccatgcccc ccctcgaggg ggagcttgga gatccagacc tggagcctga     7560

gcaggtagag ccccaacccc ccccccaggg gggggtggca gctcccggct cggactcggg     7620

gtcctggtct acttgctccg aggaggacga ctccgtcgtg tgctgctcca tgtcatactc     7680

ctggaccggg gctctaataa ctccttgtag tcccgaagag gagaagttac cgattaaccc     7740

cttgagcaac tccctgttgc gatatcacaa caaggtgtac tgtaccacaa caaagagcgc     7800

ctcactaagg gctaaaaagg taacttttga taggatgcaa gtgctcgact cctactacga     7860

ctcagtctta aaggacatta agctagcggc ctccaaggtc accgcaaggc tcctcaccat     7920

ggaggaggct tgccagttaa ccccacccca ttctgcaaga tctaaatatg ggtttggggc     7980

taaggaggtc cgcagcttgt ccgggagggc cgttaaccac atcaagtccg tgtggaagga     8040

cctcctggag gactcagaaa caccaattcc cacaaccatt atggccaaaa atgaggtgtt     8100

ctgcgtggac cccaccaagg ggggcaagaa agcagctcgc cttatcgttt accctgacct     8160

cggcgtcagg gtctgcgaga agatggccct ttatgacatt acacaaaaac ttcctcaggc     8220

ggtgatgggg gcttcttatg gattccagta ttcccccgct cagcgggtag agtttctctt     8280

gaaagcatgg gcggaaaaga aggaccctat gggtttttcg tatgataccc gatgctttga     8340

ctcaaccgtc actgagagag acatcaggac tgaggagtcc atatatcggg cctgctcctt     8400

gcccgaggag gcccacactg ccatacactc gctaactgag agactttacg tgggagggcc     8460

tatgttcaac agcaagggcc aaacctgcgg gtacaggcgt tgccgcgcca gcggggtgct     8520

caccactagc atggggaaca ccatcacatg ctacgtgaaa gccttagcgg cttgtaaagc     8580

tgcagggata atcgcgccca caatgctggt atgcggcgat gacttggttg tcatctcaga     8640

aagccagggg accgaggagg acgagcggaa cctgagagcc ttcacggagg ctatgaccag     8700

gtattctgcc cctcctggtg acccccccag accggagtat gatctggagc tgataacatc     8760

ttgctcctca aatgtgtctg tggcgttggg cccgcggggc cgccgcagat actacctgac     8820

cagagaccca accactccac tcgcccgggc tgcctgggaa acagttagac actcccctat     8880

caattcatgg ctgggaaaca tcatccagta tgctccaacc atatgggttc gcatggtcct     8940

aatgacacac ttcttctcca ttctcatggt ccaagacacc ctggaccaga acctcaactt     9000

tgagatgtat ggatcagtat actccgtgaa tcctttggac cttccagcca taattgagag     9060

gttacacggg cttgacgcct tttctatgca cacatactct caccacgaac tgacgcgggt     9120

ggcttcagcc ctcagaaaac ttggggcgcc acccctcagg gtgtggaaga gtcgggctcg     9180

cgcagtcagg gcgtccctca tctcccgtgg agggaaagcg gccgtttgcg gccgatatct     9240

cttcaattgg gcggtgaaga ccaagctcaa actcactcca ttgccggagg cgcgcctact     9300

ggacttatcc agttggttca ccgtcggcgc cggcgggggc gacatttttc acagcgtgtc     9360

gcgcgcccga ccccgctcat tactcttcgg cctactccta cttttcgtag gggtaggcct     9420

cttcctactc cccgctcggt agagcggcac acactaggta cactccatag ctaactgttc     9480

cttttttttt tttttttttt tttttttttt tttttttttt ttttcttttt tttttttttc     9540

cctctttctt cccttctcat cttattctac tttctttctt ggtggctcca tcttagccct     9600

agtcacggct agctgtgaaa ggtccgtgag ccgcatgact gcagagagtg ccgtaactgg     9660

tctctctgca gatcatgt                                                   9678


<210>  14
<211>  9678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  14
acccgcccct aataggggcg acactccgcc atgaatcact cccctgtgag gaactactgt       60

cttcacgcag aaagcgtcta gccatggcgt tagtatgagt gtcgtacagc ctccaggccc      120

ccccctcccg ggagagccat agtggtctgc ggaaccggtg agtacaccgg aattgccggg      180

aagactgggt cctttcttgg ataaacccac tctatgcccg gccatttggg cgtgcccccg      240

caagactgct agccgagtag cgttgggttg cgaaaggcct tgtggtactg cctgataggg      300

tgcttgcgag tgccccggga ggtctcgtag accgtgcacc atgagcacaa atcctaaacc      360

tcaaagaaaa accaaaagaa acaccaaccg tcgcccacaa gacgttaagt ttccgggcgg      420

cggccagatc gttggcggag tatacttgtt gccgcgcagg ggccccaggt tgggtgtgcg      480

cgcgacaagg aagacttcgg agcggtccca gccacgtgga aggcgccagc ccatccctaa      540

agatcggcgc tccactggca aatcctgggg aaaaccagga tacccctggc ccctatacgg      600

gaatgaggga ctcggctggg caggatggct cctgtccccc cgaggttccc gtccctcttg      660

gggccccaat gacccccggc ataggtcgcg caacgtgggt aaggtcatcg ataccctaac      720

gtgcggcttt gccgacctca tggggtacat ccctgtcgtg ggcgccccgc tcggcggcgt      780

cgccagagct ctcgcgcatg gcgtgagagt cctggaggac ggggttaatt ttgcaacagg      840

gaacttaccc ggttgctcct tttctatctt cttgctggcc ctgctgtcct gcatcaccac      900

cccggtctcc gctgccgaag tgaagaacat cagtaccggc tacatggtga ctaacgactg      960

caccaatgac agcattacct ggcagctcca ggctgctgtc ctccacgtcc ccgggtgcgt     1020

cccgtgcgag aaagtgggga atgcatctca gtgctggata ccggtctcac cgaatgtggc     1080

cgtgcagcgg cccggcgccc tcacgcaggg cttgcggacg cacatcgaca tggttgtgat     1140

gtccgccacg ctctgctctg ccctctacgt gggggacctc tgcggtgggg tgatgctcgc     1200

agcccaaatg ttcattgtct cgccgcagca ccactggttt gtccaagact gcaattgctc     1260

catctaccct ggtaccatca ctggacaccg catggcatgg gacatgatga tgaactggtc     1320

gcccacggct accatgatct tggcgtacgc gatgcgtgtc cccgaggtca ttatagacat     1380

cattagcggg gctcattggg gcgtcatgtt cggcttggcc tacttctcta tgcagggagc     1440

gtgggcgaaa gtcgttgtca tccttctgtt ggccgccggg gtggacgcgc gcacccatac     1500

tgttgggggt tctgccgcgc agaccaccgg gcgcctcacc agcttatttg acatgggccc     1560

caggcagaaa atccagctcg ttaacaccaa tggcagctgg cacatcaacc gcaccgccct     1620

gaactgcaat gactccttgc acaccggctt tatcgcgtct ctgttctaca cccacagctt     1680

caactcgtca ggatgtcccg aacgcatgtc cgcctgccgc agtatcgagg ccttccgggt     1740

gggatggggc gccttgcaat atgaggataa tgtcaccaat ccagaggata tgagacccta     1800

ttgctggcac tacccaccaa ggcagtgtgg cgtggtctcc gcgaagactg tgtgtggccc     1860

agtgtactgt ttcaccccca gcccagtggt agtgggcacg accgacaggc ttggagcgcc     1920

cacttacacg tggggggaga atgagacaga tgtcttccta ttgaacagca ctcgaccacc     1980

gctggggtca tggttcggct gcacgtggat gaactcttct ggctacacca agacttgcgg     2040

cgcaccaccc tgccgtacta gagctgactt caacgccagc acggacctgt tgtgccccac     2100

ggactgtttt aggaagcatc ctgataccac ttacctcaaa tgcggctctg ggccctggct     2160

cacgccaagg tgcctgatcg actaccccta caggctctgg cattacccct gcacagttaa     2220

ctataccatc ttcaaaataa ggatgtatgt gggaggggtt gagcacaggc tcacggctgc     2280

atgcaatttc actcgtgggg atcgttgcaa cttggaggac agagacagaa gtcaactgtc     2340

tcctttgttg cactccacca cggaatgggc cattttacct tgctcttact cggacctgcc     2400

cgccttgtcg actggtcttc tccacctcca ccaaaacatc gtggacgtac aattcatgta     2460

tggcctatca cctgccctca caaaatacat cgtccgatgg gagtgggtaa tactcttatt     2520

cctgctctta gcggacgcca gggtttgcgc ctgcttatgg atgctcatct tgttgggcca     2580

ggccgaagca gcactagaga agctggtcat cttgcacgct gcgagcgcag ctagctgcaa     2640

tggcttccta tattttgtca tctttttcgt ggctgcttgg tacatcaagg gtcgggtagt     2700

ccccttagct acctattccc tcactggcct gtggtccttt agcctactgc tcctagcatt     2760

gccccaacag gcttatgctt atgacgcatc tgtgcatggc cagataggag cggctctgct     2820

ggtaatgatc actctcttta ctctcacccc cgggtataag acccttctca gccggttttt     2880

gtggtggttg tgctatcttc tgaccctggg ggaagctatg gtccaggagt gggcaccacc     2940

tatgcaggtg cgcggtggcc gtgatggcat catatgggcc gtcgccatat tctacccagg     3000

tgtggtgttt gacataacca agtggctctt ggcggtgctt gggcctgctt acctcctaaa     3060

aggtgctttg acgcgcgtgc cgtacttcgt cagggctcac gctctactga ggatgtgcac     3120

catggcaagg catctcgcgg ggggcaggta cgtccagatg gcgctactag cccttggcag     3180

gtggactggc acttacatct atgaccacct cacccctatg tcggattggg ctgctagtgg     3240

cctgcgggac ctggcggtcg ccgttgagcc tatcatcttc agtccgatgg agaagaaagt     3300

cattgtctgg ggagcggaga cagctgcttg tggggacatt ttacacggac ttcccgtgtc     3360

cgcccgactt ggtcgggagg tcctccttgg cccagctgat ggctatacct ccaaggggtg     3420

gagtcttctc gcccccatca ctgcttacgc ccagcagaca cgtggccttt tgggcaccat     3480

agtggtgagc atgacggggc gcgacaagac agaacaggct ggggaaattc aggtcctgtc     3540

cacagtcact cagtccttcc tcggaacatc catctcgggg gttttgtgga ctgtctacca     3600

tggagctggc aacaagactc tggccggctc acggggtccg gtcacgcaga tgtactccag     3660

tgctgagggg gacttagtag ggtggcccag cccccctggg actaaatctt tggagccgtg     3720

cacgtgtgga gcggtcgacc tgtacctggt cacgcggaac gctgatgtca tcccggctcg     3780

aagacgcggg gacaaacggg gagcgctact ctccccgaga cctctttcca ccttgaaggg     3840

gtcctcagga ggcccggtgc tatgccccag gggccacgct gtcggagtct tccgggcagc     3900

tgtgtgctct cggggcgtgg ctaagtccat agatttcatc cccgttgaga cactcgacat     3960

cgtcacgcgg tcccccacct ttagtgacaa cagcacacca cctgctgtgc cccagaccta     4020

tcaggtcggg tacttgcatg ccccgactgg cagtggaaag agcaccaaag ttcctgtcgc     4080

atatgctgct caggggtata aagtgctagt gcttaatccc tcagtggctg ccaccctggg     4140

gtttggggcg tacttgtcta aggcacatgg catcaatccc aacattagga ctggagtcag     4200

gactgtgacg accggggcgc ccatcacgta ctccacatat ggcaaattcc tcgccgatgg     4260

gggctgtgcg ggcggcgcct acgacatcat catatgtgat gaatgccatg ccgtggactc     4320

taccaccatc cttggcatcg gaacagtcct tgatcaagca gagacagctg gggtcagact     4380

aactgtgctg gctacagcta cgccccctgg gtcagtgaca accccccacc ccaacataga     4440

ggaggtggcc cttgggcagg agggcgagat ccccttctat gggagggcga ttcccctgtc     4500

ttacatcaag ggaggaagac atctgatctt ctgccattca aagaaaaagt gtgacgagct     4560

cgcggcggcc cttcggggta tgggcttgaa ctcagtggca tactacagag ggttggacgt     4620

ctccgtaata ccaactcagg gagacgtagt ggtcgtcgcc accgacgccc tcatgacagg     4680

gtatactggg gactttgact ccgtgatcga ctgcaacgta gcggtcactc aagttgtaga     4740

cttcagttta gaccccacat tcaccataac cacacagatt gtccctcaag acgctgtctc     4800

acgtagccag cgccggggtc gcacgggtag gggaagactg ggcatttata ggtatgtttc     4860

cactggtgag cgagcctcag gaatgtttga cagtgtagtg ctctgtgagt gctacgacgc     4920

aggggccgca tggtatgagc tcacaccatc ggagaccacc gtcaggctca gggcgtattt     4980

caacacgccc ggtttgcctg tgtgccaaga ccatcttgag ttttgggagg cagttttcac     5040

cggcctcaca cacatagatg cccacttcct ttcccaaaca aagcaatcgg gggaaaattt     5100

cgcatactta acagcctacc aggctacagt gtgcgctagg gccaaagccc cccccccgtc     5160

ctgggacgtc atgtggaagt gtttgactcg actcaagccc acactcgtgg gccccacacc     5220

tctcctgtac cgcttgggct ctgttaccaa cgaggtcacc ctcacacatc ccgtgacgaa     5280

atacatcgcc acctgcatgc aagccgacct tgaggtcatg accagcacat gggtcttggc     5340

agggggagtc ttggcggccg tcgcctcgta ttgcctggcg accgggtgtg tttgcatcat     5400

cggccgcttg cacattaacc agcgagccgt cgttgcgccg gacaaggagg tcctctatga     5460

ggcttttgat gagatggagg aatgtgcctc tagggcggct ctcattgaag aggggcagcg     5520

gatagccgag atgctgaagt ccaagatcca aggcttattg cagcaagctt ccaaacaagc     5580

tcaagacata caacccactg tgcaggcttc atggcccaag gtagaacaat tctgggccaa     5640

acacatgtgg aacttcatta gcggcatcca atacctcgca ggactatcaa cactgccagg     5700

gaaccctgca gtagcttcca tgatggcgtt cagtgccgcc ctcaccagtc cgctgtcaac     5760

aagcaccact atccttctca acattttggg gggctggcta gcatcccaaa ttgcaccacc     5820

cgcgggggcc actggcttcg ttgtcagtgg cctagtggga gctgccgtag gcagtatagg     5880

cttaggtaag gtgctagtgg acatcctggc agggtatggt gcgggcattt cgggggctct     5940

cgtcgcattc aagatcatgt ctggcgagaa gccctccatg gaggatgtcg tcaacttgct     6000

gcctggaatt ctgtctccgg gtgccttggt agtgggagtc atctgcgcgg ccattctgcg     6060

ccgacacgtg ggaccggggg aaggcgccgt ccaatggatg aatagactca ttgcctttgc     6120

ttccagagga aatcacgtcg cccccaccca ctacgtgacg gagtcggatg cgtcgcagcg     6180

tgtgacccaa ctacttggct cccttaccat aaccagcctg ctcagaagac tccacaactg     6240

gattactgag gactgcccca tcccatgcgg cggctcgtgg ctccgcgatg tgtgggactg     6300

ggtttgcacc atcctaacag actttaaaaa ttggctgacc tccaaattat tcccaaagat     6360

gcccggcctc ccctttgtct cctgtcaaaa ggggtacaag ggcgtgtggg ccggcactgg     6420

catcatgacc acacggtgtc cttgcggcgc caatatctct ggcaatgtcc gcttgggctc     6480

catgagaatc acggggccta agacctgcat gaatatctgg caggggacct ttcctatcaa     6540

ttgttacacg gagggccagt gcgtgccgaa acccgcgcca aactttaagg tcgccatctg     6600

gagggtggcg gcctcagagt acgcggaggt gacgcagcac gggtcatacc actacataac     6660

aggactcacc actgataact tgaaagtccc ctgccaacta ccctctcccg agttcttttc     6720

ctgggtggac ggagtgcaga tccataggtt tgcccccaca ccgaagccgt ttttccggga     6780

tgaggtctcg ttctgcgttg ggcttaattc atttgtcgtc gggtcccagc ttccttgcga     6840

ccctgaaccc gacacagacg tattgatgtc catgctaaca gatccatctc atatcacggc     6900

ggagactgca gcgcggcgtt tagcgcgggg gtcaccccca tccgaggcaa gctcctcggc     6960

gagccagcta tcggcaccat cgctgcgagc cacctgcacc acccacggca aagcctatga     7020

tgtggacatg gtggatgcta acctgttcat ggggggcgat gtgactcgga tagagtctgg     7080

gtccaaagtg gtcgttctgg actctctcga cccaatggtc gaagaaagga gcgaccttga     7140

gccttcgata ccatcagaat acatgctccc caagaagagg ttcccaccag ctttaccggc     7200

ctgggcacgg cctgattaca acccaccgct tgtggaatcg tggaaaaggc cagattacca     7260

accggccact gttgcgggct gtgctctccc tcctcctagg aaaaccccga cgcctccccc     7320

aaggaggcgc cggacagtgg gcctaagtga ggactccata ggagatgccc ttcaacagct     7380

ggccattaag tcctttggcc agcccccccc aagcggcgat tcaggccttt ccacgggggc     7440

gggcgctgcc gattccggca gtcagacgcc tcctgatgag ttggcccttt cggagacagg     7500

ttccatctct tccatgcccc ccctcgaggg ggagcttgga gatccagacc tggagcctga     7560

gcaggtagag ccccaacccc ccccccaggg gggggtggca gctcccggct cggactcggg     7620

gtcctggtct acttgctccg aggaggacga ctccgtcgtg tgctgctcca tgtcatactc     7680

ctggaccggg gctctaataa ctccttgtag tcccgaagag gagaagttac cgattaaccc     7740

cttgagcaac tccctgttgc gatatcacaa caaggtgtac tgtaccacaa caaagagcgc     7800

ctcactaagg gctaaaaagg taacttttga taggatgcaa gtgctcgact cctactacga     7860

ctcagtctta aaggacatta agctagcggc ctccaaggtc accgcaaggc tcctcaccat     7920

ggaggaggct tgccagttaa ccccacccca ttctgcaaga tctaaatatg ggtttggggc     7980

taaggaggtc cgcagcttgt ccgggagggc cgttaaccac atcaagtccg tgtggaagga     8040

cctcctggag gactcagaaa caccaattcc cacaaccatt atggccaaaa atgaggtgtt     8100

ctgcgtggac cccaccaagg ggggcaagaa agcagctcgc cttatcgttt accctgacct     8160

cggcgtcagg gtctgcgaga agatggccct ttatgacatt acacaaaaac ttcctcaggc     8220

ggtgatgggg gcttcttatg gattccagta ttcccccgct cagcgggtag agtttctctt     8280

gaaagcatgg gcggaaaaga aggaccctat gggtttttcg tatgataccc gatgctttga     8340

ctcaaccgtc actgagagag acatcaggac tgaggagtcc atatatcggg cctgctcctt     8400

gcccgaggag gcccacactg ccatacactc gctaactgag agactttacg tgggagggcc     8460

tatgttcaac agcaagggcc aaacctgcgg gtacaggcgt tgccgcgcca gcggggtgct     8520

caccactagc atggggaaca ccatcacatg ctacgtgaaa gccttagcgg cttgtaaagc     8580

tgcagggata atcgcgccca caatgctggt atgcggcgat gacttggttg tcatctcaga     8640

aagccagggg accgaggagg acgagcggaa cctgagagcc ttcacggagg ctatgaccag     8700

gtattctgcc cctcctggtg acccccccag accggagtat gatctggagc tgataacatc     8760

ttgctcctca aatgtgtctg tggcgttggg cccgcggggc cgccgcagat actacctgac     8820

cagagaccca accactccac tcgcccgggc tgcctgggaa acagttagac actcccctat     8880

caattcatgg ctgggaaaca tcatccagta tgctccaacc atatgggttc gcatggtcct     8940

aatgacacac ttcttctcca ttctcatggt ccaagacacc ctggaccaga acctcaactt     9000

tgagatgtat ggatcagtat actccgtgaa tcctttggac cttccagcca taattgagag     9060

gttacacggg cttgacgcct tttctatgca cacatactct caccacgaac tgacgcgggt     9120

ggcttcagcc ctcagaaaac ttggggcgcc acccctcagg gtgtggaaga gtcgggctcg     9180

cgcagtcagg gcgtccctca tctcccgtgg agggaaagcg gccgtttgcg gccgatatct     9240

cttcaattgg gcggtgaaga ccaagctcaa actcactcca ttgccggagg cgcgcctact     9300

ggacttatcc agttggttca ccgtcggcgc cggcgggggc gacatttttc acagcgtgtc     9360

gcgcgcccga ccccgctcat tactcttcgg cctactccta cttttcgtag gggtaggcct     9420

cttcctactc cccgctcggt agagcggcac acactaggta cactccatag ctaactgttc     9480

cttttttttt tttttttttt tttttttttt tttttttttt ttttcttttt tttttttttc     9540

cctctttctt cccttctcat cttattctac tttctttctt ggtggctcca tcttagccct     9600

agtcacggct agctgtgaaa ggtccgtgag ccgcatgact gcagagagtg ccgtaactgg     9660

tctctctgca gatcatgt                                                   9678


<210>  15
<211>  9711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  15
acccgcccct aataggggcg acactccgcc atgaatcact cccctgtgag gaactactgt       60

cttcacgcag aaagcgtcta gccatggcgt tagtatgagt gtcgtacagc ctccaggccc      120

ccccctcccg ggagagccat agtggtctgc ggaaccggtg agtacaccgg aattgccggg      180

aagactgggt cctttcttgg ataaacccac tctatgcccg gccatttggg cgtgcccccg      240

caagactgct agccgagtag cgttgggttg cgaaaggcct tgtggtactg cctgataggg      300

tgcttgcgag tgccccggga ggtctcgtag accgtgcacc atgagcacaa atcctaaacc      360

tcaaagaaaa accaaaagaa acaccaaccg tcgcccacaa gacgttaagt ttccgggcgg      420

cggccagatc gttggcggag tatacttgtt gccgcgcagg ggccccaggt tgggtgtgcg      480

cgcgacaagg aagacttcgg agcggtccca gccacgtgga aggcgccagc ccatccctaa      540

agatcggcgc tccactggca aatcctgggg aaaaccagga tacccctggc ccctatacgg      600

gaatgaggga ctcggctggg caggatggct cctgtccccc cgaggttccc gtccctcttg      660

gggccccaat gacccccggc ataggtcgcg caacgtgggt aaggtcatcg ataccctaac      720

gtgcggcttt gccgacctca tggggtacat ccctgtcgtg ggcgccccgc tcggcggcgt      780

cgccagagct ctcgcgcatg gcgtgagagt cctggaggac ggggttaatt ttgcaacagg      840

gaacttaccc ggttgctcct tttctatctt cttgctggcc ctgctgtcct gcatcaccac      900

cccggtctcc gctgccgaag tgaagaacat cagtaccggc tacatggtga ctaacgactg      960

caccaatgac agcattacct ggcagctcca ggctgctgtc ctccacgtcc ccgggtgcgt     1020

cccgtgcgag aaagtgggga atgcatctca gtgctggata ccggtctcac cgaatgtggc     1080

cgtgcagcgg cccggcgccc tcacgcaggg cttgcggacg cacatcgaca tggttgtgat     1140

gtccgccacg ctctgctctg ccctctacgt gggggacctc tgcggtgggg tgatgctcgc     1200

agcccaaatg ttcattgtct cgccgcagca ccactggttt gtccaagact gcaattgctc     1260

catctaccct ggtaccatca ctggacaccg catggcatgg gacatgatga tgaactggtc     1320

gcccacggct accatgatct tggcgtacgc gatgcgtgtc cccgaggtca ttatagacat     1380

cattagcggg gctcattggg gcgtcatgtt cggcttggcc tacttctcta tgcagggagc     1440

gtgggcgaaa gtcgttgtca tccttctgtt ggccgccggg gtggacgcgc gcacccatac     1500

tgttgggggt tctgccgcgc agaccaccgg gcgcctcacc agcttatttg acatgggccc     1560

caggcagaaa atccagctcg ttaacaccaa tggcagctgg cacatcaacc gcaccgccct     1620

gaactgcaat gactccttgc acaccggctt tatcgcgtct ctgttctaca cccacagctt     1680

caactcgtca ggatgtcccg aacgcatgtc cgcctgccgc agtatcgagg ccttccgggt     1740

gggatggggc gccttgcaat atgaggataa tgtcaccaat ccagaggata tgagacccta     1800

ttgctggcac tacccaccaa ggcagtgtgg cgtggtctcc gcgaagactg tgtgtggccc     1860

agtgtactgt ttcaccccca gcccagtggt agtgggcacg accgacaggc ttggagcgcc     1920

cacttacacg tggggggaga atgagacaga tgtcttccta ttgaacagca ctcgaccacc     1980

gctggggtca tggttcggct gcacgtggat gaactcttct ggctacacca agacttgcgg     2040

cgcaccaccc tgccgtacta gagctgactt caacgccagc acggacctgt tgtgccccac     2100

ggactgtttt aggaagcatc ctgataccac ttacctcaaa tgcggctctg ggccctggct     2160

cacgccaagg tgcctgatcg actaccccta caggctctgg cattacccct gcacagttaa     2220

ctataccatc ttcaaaataa ggatgtatgt gggaggggtt gagcacaggc tcacggctgc     2280

atgcaatttc actcgtgggg atcgttgcaa cttggaggac agagacagaa gtcaactgtc     2340

tcctttgttg cactccacca cggaatgggc cattttacct tgctcttact cggacctgcc     2400

cgccttgtcg actggtcttc tccacctcca ccaaaacatc gtggacgtac aattcatgta     2460

tggcctatca cctgccctca caaaatacat cgtccgatgg gagtgggtaa tactcttatt     2520

cctgctctta gcggacgcca gggtttgcgc ctgcttatgg atgctcatct tgttgggcca     2580

ggccgaagca gcactagaga agctggtcat cttgcacgct gcgagcgcag ctagctgcaa     2640

tggcttccta tattttgtca tcttttccgt ggctgcttgg tacatcaagg gtcgggtagt     2700

ccccttagct acctattccc tcactggcct gtggtccttt agcctactgc tcctagcatt     2760

gccccaacag gcttatgctt atgacgcatc tgtgcatggc cagataggag cggctctgct     2820

ggtaatgatc actctcttta ctctcacccc cgggtataag acccttctca gccggttttt     2880

gtggtggttg tgctatcttc tgaccctggg ggaagctatg gtccaggagt gggcaccacc     2940

tatgcaggtg cgcggtggcc gtgatggcat catatgggcc gtcgccatat tctacccagg     3000

tgtggtgttt gacataacca agtggctctt ggcggtgctt gggcctgctt acctcctaaa     3060

aggtgctttg acgcgcgtgc cgtacttcgt cagggctcac gctctactga ggatgtgcac     3120

catggcaagg catctcgcgg ggggcaggta cgtccagatg gcgctactag cccttggcag     3180

gtggactggc acttacatct atgaccacct cacccctatg tcggattggg ctgctagtgg     3240

cctgcgggac ctggcggtcg ccgttgagcc tatcatcttc agtccgatgg agaagaaagt     3300

cattgtctgg ggagcggaga cagctgcttg tggggacatt ttacacggac ttcccgtgtc     3360

cgcccgactt ggtcgggagg tcctccttgg cccagctgat ggctatacct ccaaggggtg     3420

gagtcttctc gcccccatca ctgcttacgc ccagcagaca cgtggccttt tgggcaccat     3480

agtggtgagc atgacggggc gcgacaagac agaacaggct ggggaaattc aggtcctgtc     3540

cacagtcact cagtccttcc tcggaacatc catctcgggg gttttgtgga ctgtctacca     3600

tggagctggc aacaagactc tggccggctc acggggtccg gtcacgcaga tgtactccag     3660

tgctgagggg gacttagtag ggtggcccag cccccctggg actaaatctt tggagccgtg     3720

cacgtgtgga gcggtcgacc tgtacctggt cacgcggaac gctgatgtca tcccggctcg     3780

aagacgcggg gacaaacggg gagcgctact ctccccgaga cctctttcca ccttgaaggg     3840

gtcctcagga ggcccggtgc tatgccccag gggccacgct gtcggagtct tccgggcagc     3900

tgtgtgctct cggggcgtgg ctaagtccat agatttcatc cccgttgaga cactcgacat     3960

cgtcacgcgg tcccccacct ttagtgacaa cagcacacca cctgctgtgc cccagaccta     4020

tcaggtcggg tacttgcatg ccccgactgg cagtggaaag agcaccaaag ttcctgtcgc     4080

atatgctgct caggggtata aagtgctagt gcttaatccc tcagtggctg ccaccctggg     4140

gtttggggcg tacttgtcta aggcacatgg catcaatccc aacattagga ctggagtcag     4200

gactgtgacg accggggcgc ccatcacgta ctccacatat ggcaaattcc tcgccgatgg     4260

gggctgtgcg ggcggcgcct acgacatcat catatgtgat gaatgccatg ccgtggactc     4320

taccaccatc cttggcatcg gaacagtcct tgatcaagca gagacagctg gggtcagact     4380

aactgtgctg gctacagcta cgccccctgg gtcagtgaca accccccacc ccaacataga     4440

ggaggtggcc cttgggcagg agggcgagat ccccttctat gggagggcga ttcccctgtc     4500

ttacatcaag ggaggaagac atctgatctt ctgccattca aagaaaaagt gtgacgagct     4560

cgcggcggcc cttcggggta tgggcttgaa ctcagtggca tactacagag ggttggacgt     4620

ctccgtaata ccaactcagg gagacgtagt ggtcgtcgcc accgacgccc tcatgacagg     4680

gtatactggg gactttgact ccgtgatcga ctgcaacgta gcggtcactc aagttgtaga     4740

cctcagttta gaccccacat tcaccataac cacacagatt gtccctcaag acgctgtctc     4800

acgtagccag cgccggggtc gcacgggtag gggaagactg ggcatttata ggtatgtttc     4860

cactggtgag cgagcctcag gaatgtttga cagtgtagtg ctctgtgagt gctacgacgc     4920

aggggccgca tggtatgagc tcacaccatc ggagaccacc gtcaggctca gggcgtattt     4980

caacacgccc ggtttgcctg tgtgccaaga ccatcttgag ttttgggagg cagttttcac     5040

cggcctcaca cacatagatg cccacttcct ttcccaaaca aagcaatcgg gggaaaattt     5100

cgcatactta acagcctacc aggctacagt gtgcgctagg gccaaagccc cccccccgtc     5160

ctgggacgtc atgtggaagt gtttgactcg actcaagccc acactcgtgg gccccacacc     5220

tctcctgtac cgcttgggct ctgttaccaa cgaggtcacc ctcacacatc ccgtgacgaa     5280

atacatcgcc acctgcatgc aagccgacct tgaggtcatg accagcacat gggtcttggc     5340

agggggagtc ttggcggccg tcgcctcgta ttgcctggcg accgggtgtg tttgcatcat     5400

cggccgcttg cacattaacc agcgagccgt cgttgcgccg gacaaggagg tcctctatga     5460

ggcttttgat gagatggagg aatgtgcctc tagggcggct ctcattgaag aggggcagcg     5520

gatagccgag atgctgaagt ccaagatcca aggcttattg cagcaagctt ccaaacaagc     5580

tcaagacata caacccactg tgcaggcttc atggcccaag gtagaacaat tctgggccaa     5640

acacatgtgg aacttcatta gcggcatcca atacctcgca ggactatcaa cactgccagg     5700

gaaccctgca gtagcttcca tgatggcgtt cagtgccgcc ctcaccagtc cgctgtcaac     5760

aagcaccact atccttctca acattttggg gggctggcta gcatcccaaa ttgcaccacc     5820

cgcgggggcc actggcttcg ttgtcagtgg cctagtggga gctgccgtag gcagtatagg     5880

cttaggtaag gtgctagtgg acatcctggc agggtatggt gcgggcattt cgggggctct     5940

cgtcgcattc aagatcatgt ctggcgagaa gccctccatg gaggatgtcg tcaacttgct     6000

gcctggaatt ctgtctccgg gtgccttggt agtgggagtc atctgcgcgg ccattctgcg     6060

ccgacacgtg ggaccggggg aaggcgccgt ccaatggatg aatagactca ttgcctttgc     6120

ttccagagga aatcacgtcg cccccaccca ctacgtgacg gagtcggatg cgtcgcagcg     6180

tgtgacccaa ctacttggct cccttaccat aaccagcctg ctcagaagac tccacaactg     6240

gattactgag gactgcccca tcccatgcgg cggctcgtgg ctccgcgatg tgtgggactg     6300

ggtttgcacc atcctaacag actttaaaaa ttggctgacc tccaaattat tcccaaagat     6360

gcccggcctc ccctttgtct cctgtcaaaa ggggtacaag ggcgtgtggg ccggcactgg     6420

catcatgacc acacggtgtc cttgcggcgc caatatctct ggcaatgtcc gcttgggctc     6480

catgagaatc acggggccta agacctgcat gaatatctgg caggggacct ttcctatcaa     6540

ttgttacacg gagggccagt gcgtgccgaa acccgcgcca aactttaagg tcgccatctg     6600

gagggtggcg gcctcagagt acgcggaggt gacgcagcac gggtcatacc actacataac     6660

aggactcacc actgataact tgaaagtccc ctgccaacta ccctctcccg agttcttttc     6720

ctgggtggac ggagtgcaga tccataggtt tgcccccaca ccgaagccgt ttttccggga     6780

tgaggtctcg ttctgcgttg ggcttaattc atttgtcgtc gggtcccagc ttccttgcga     6840

ccctgaaccc gacacagacg tattgatgtc catgctaaca gatccatctc atatcacggc     6900

ggagactgca gcgcggcgtt tagcgcgggg gtcaccccca tccgaggcaa gctcctcggc     6960

gagccagcta tcggcaccat cgctgcgagc cacctgcacc acccacggca aagcctatga     7020

tgtggacatg gtggatgcta acctgttcat ggggggcgat gtgactcgga tagagtctgg     7080

gtccaaagtg gtcgttctgg actctctcga cccaatggtc gaagaaagga gcgaccttga     7140

gccttcgata ccatcagaat acatgctccc caagaagagg ttcccaccag ctttaccggc     7200

ctgggcacgg cctgattaca acccaccgct tgtggaatcg tggaaaaggc cagattacca     7260

accggccact gttgcgggct gtgctctccc tcctcctagg aaaaccccga cgcctccccc     7320

aaggaggcgc cggacagtgg gcctaagtga ggactccata ggagatgccc ttcaacagct     7380

ggccattaag tcctttggcc agcccccccc aagcggcgat tcaggccttt ccacgggggc     7440

gggcgctgcc gattccggca gtcagacgcc tcctgatgag ttggcccttt cggagacagg     7500

ttccatctct tccatgcccc ccctcgaggg ggagcttgga gatccagacc tggagcctga     7560

gcaggtagag ccccaacccc ccccccaggg gggggtggca gctcccggct cggactcggg     7620

gtcctggtct acttgctccg aggaggacga ctccgtcgtg tgctgctcca tgtcatactc     7680

ctggaccggg gctctaataa ctccttgtag tcccgaagag gagaagttac cgattaaccc     7740

cttgagcaac tccctgttgc gatatcacaa caaggtgtac tgtaccacaa caaagagcgc     7800

ctcactaagg gctaaaaagg taacttttga taggatgcaa gtgctcgact cctactacga     7860

ctcagtctta aaggacatta agctagcggc ctccaaggtc accgcaaggc tcctcaccat     7920

ggaggaggct tgccagttaa ccccacccca ttctgcaaga tctaaatatg ggtttggggc     7980

taaggaggtc cgcagcttgt ccgggagggc cgttaaccac atcaagtccg tgtggaagga     8040

cctcctggag gactcagaaa caccaattcc cacaaccatt atggccaaaa atgaggtgtt     8100

ctgcgtggac cccaccaagg ggggcaagaa agcagctcgc cttatcgttt accctgacct     8160

cggcgtcagg gtctgcgaga agatggccct ttatgacatt acacaaaaac ttcctcaggc     8220

ggtgatgggg gcttcttatg gattccagta ttcccccgct cagcgggtag agtttctctt     8280

gaaagcatgg gcggaaaaga aggaccctat gggtttttcg tatgataccc gatgctttga     8340

ctcaaccgtc actgagagag acatcaggac tgaggagtcc atatatcggg cctgctcctt     8400

gcccgaggag gcccacactg ccatacactc gctaactgag agactttacg tgggagggcc     8460

tatgttcaac agcaagggcc aaacctgcgg gtacaggcgt tgccgcgcca gcggggtgct     8520

caccactagc atggggaaca ccatcacatg ctacgtgaaa gccttagcgg cttgtaaagc     8580

tgcagggata atcgcgccca caatgctggt atgcggcgat gacttggttg tcatctcaga     8640

aagccagggg accgaggagg acgagcggaa cctgagagcc ttcacggagg ctatgaccag     8700

gtattctgcc cctcctggtg acccccccag accggagtat gatctggagc tgataacatc     8760

ttgctcctca aatgtgtctg tggcgttggg cccgcggggc cgccgcagat actacctgac     8820

cagagaccca accactccac tcgcccgggc tgcctgggaa acagttagac actcccctat     8880

caattcatgg ctgggaaaca tcatccagta tgctccaacc atatgggttc gcatggtcct     8940

aatgacacac ttcttctcca ttctcatggt ccaagacacc ctggaccaga acctcaactt     9000

tgagatgtat ggatcagtat actccgtgaa tcctttggac cttccagcca taattgagag     9060

gttacacggg cttgacgcct tttctatgca cacatactct caccacgaac tgacgcgggt     9120

ggcttcagcc ctcagaaaac ttggggcgcc acccctcagg gtgtggaaga gtcgggctcg     9180

cgcagtcagg gcgtccctca tctcccgtgg agggaaagcg gccgtttgcg gccgatatct     9240

cttcaattgg gcggtgaaga ccaagctcaa actcactcca ttgccggagg cgcgcctact     9300

ggacttatcc agttggttca ccgtcggcgc cggcgggggc gacatttttc acagcgtgtc     9360

gcgcgcccga ccccgctcat tactcttcgg cctactccta cttttcgtag gggtaggcct     9420

cttcctactc cccgctcggt agagcggcac acattagcta cactccatag ctaactgtcc     9480

cttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     9540

tttttttttt tttttttttt tttttctttt tttctctttt ccttctttct taccttattt     9600

tactttcttt cctggtggct ccatcttagc cctagtcacg gctagctgtg aaaggtccgt     9660

gagccgcatg actgcagaga gtgccgtaac tggtctctct gcagatcatg t              9711


<210>  16
<211>  9711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  16
acccgcccct aataggggcg acactccgcc atgaatcact cccctgtgag gaactactgt       60

cttcacgcag aaagcgtcta gccatggcgt tagtatgagt gtcgtacagc ctccaggccc      120

ccccctcccg ggagagccat agtggtctgc ggaaccggtg agtacaccgg aattgccggg      180

aagactgggt cctttcttgg ataaacccac tctatgcccg gccatttggg cgtgcccccg      240

caagactgct agccgagtag cgttgggttg cgaaaggcct tgtggtactg cctgataggg      300

tgcttgcgag tgccccggga ggtctcgtag accgtgcacc atgagcacaa atcctaaacc      360

tcaaagaaaa accaaaagaa acaccaaccg tcgcccacaa gacgttaagt ttccgggcgg      420

cggccagatc gttggcggag tatacttgtt gccgcgcagg ggccccaggt tgggtgtgcg      480

cgcgacaagg aagacttcgg agcggtccca gccacgtgga aggcgccagc ccatccctaa      540

agatcggcgc tccactggca aatcctgggg aaaaccagga tacccctggc ccctatacgg      600

gaatgaggga ctcggctggg caggatggct cctgtccccc cgaggttccc gtccctcttg      660

gggccccaat gacccccggc ataggtcgcg caacgtgggt aaggtcatcg ataccctaac      720

gtgcggcttt gccgacctca tggggtacat ccctgtcgtg ggcgccccgc tcggcggcgt      780

cgccagagct ctcgcgcatg gcgtgagagt cctggaggac ggggttaatt ttgcaacagg      840

gaacttaccc ggttgctcct tttctatctt cttgctggcc ctgctgtcct gcatcaccac      900

cccggtctcc gctgccgaag tgaagaacat cagtaccggc tacatggtga ctaacgactg      960

caccaatgac agcattacct ggcagctcca ggctgctgtc ctccacgtcc ccgggtgcgt     1020

cccgtgcgag aaagtgggga atgcatctca gtgctggata ccggtctcac cgaatgtggc     1080

cgtgcagcgg cccggcgccc tcacgcaggg cttgcggacg cacatcgaca tggttgtgat     1140

gtccgccacg ctctgctctg ccctctacgt gggggacctc tgcggtgggg tgatgctcgc     1200

agcccaaatg ttcattgtct cgccgcagca ccactggttt gtccaagact gcaattgctc     1260

catctaccct ggtaccatca ctggacaccg catggcatgg gacatgatga tgaactggtc     1320

gcccacggct accatgatct tggcgtacgc gatgcgtgtc cccgaggtca ttatagacat     1380

cattagcggg gctcattggg gcgtcatgtt cggcttggcc tacttctcta tgcagggagc     1440

gtgggcgaaa gtcgttgtca tccttctgtt ggccgccggg gtggacgcgc gcacccatac     1500

tgttgggggt tctgccgcgc agaccaccgg gcgcctcacc agcttatttg acatgggccc     1560

caggcagaaa atccagctcg ttaacaccaa tggcagctgg cacatcaacc gcaccgccct     1620

gaactgcaat gactccttgc acaccggctt tatcgcgtct ctgttctaca cccacagctt     1680

caactcgtca ggatgtcccg aacgcatgtc cgcctgccgc agtatcgagg ccttccgggt     1740

gggatggggc gccttgcaat atgaggataa tgtcaccaat ccagaggata tgagacccta     1800

ttgctggcac tacccaccaa ggcagtgtgg cgtggtctcc gcgaagactg tgtgtggccc     1860

agtgtactgt ttcaccccca gcccagtggt agtgggcacg accgacaggc ttggagcgcc     1920

cacttacacg tggggggaga atgagacaga tgtcttccta ttgaacagca ctcgaccacc     1980

gctggggtca tggttcggct gcacgtggat gaactcttct ggctacacca agacttgcgg     2040

cgcaccaccc tgccgtacta gagctgactt caacgccagc acggacctgt tgtgccccac     2100

ggactgtttt aggaagcatc ctgataccac ttacctcaaa tgcggctctg ggccctggct     2160

cacgccaagg tgcctgatcg actaccccta caggctctgg cattacccct gcacagttaa     2220

ctataccatc ttcaaaataa ggatgtatgt gggaggggtt gagcacaggc tcacggctgc     2280

atgcaatttc actcgtgggg atcgttgcaa cttggaggac agagacagaa gtcaactgtc     2340

tcctttgttg cactccacca cggaatgggc cattttacct tgctcttact cggacctgcc     2400

cgccttgtcg actggtcttc tccacctcca ccaaaacatc gtggacgtac aattcatgta     2460

tggcctatca cctgccctca caaaatacat cgtccgatgg gagtgggtaa tactcttatt     2520

cctgctctta gcggacgcca gggtttgcgc ctgcttatgg atgctcatct tgttgggcca     2580

ggccgaagca gcactagaga agctggtcat cttgcacgct gcgagcgcag ctagctgcaa     2640

tggcttccta tattttgtca tcttttccgt ggctgcttgg tacatcaagg gtcgggtagt     2700

ccccttagct acctattccc tcactggcct gtggtccttt agcctactgc tcctagcatt     2760

gccccaacag gcttatgctt atgacgcatc tgtgcatggc cagataggag cggctctgct     2820

ggtaatgatc actctcttta ctctcacccc cgggtataag acccttctca gccggttttt     2880

gtggtggttg tgctatcttc tgaccctggg ggaagctatg gtccaggagt gggcaccacc     2940

tatgcaggtg cgcggtggcc gtgatggcat catatgggcc gtcgccatat tctacccagg     3000

tgtggtgttt gacataacca agtggctctt ggcggtgctt gggcctgctt acctcctaaa     3060

aggtgctttg acgcgcgtgc cgtacttcgt cagggctcac gctctactga ggatgtgcac     3120

catggcaagg catctcgcgg ggggcaggta cgtccagatg gcgctactag cccttggcag     3180

gtggactggc acttacatct atgaccacct cacccctatg tcggattggg ctgctagtgg     3240

cctgcgggac ctggcggtcg ccgttgagcc tatcatcttc agtccgatgg agaagaaagt     3300

cattgtctgg ggagcggaga cagctgcttg tggggacatt ttacacggac ttcccgtgtc     3360

cgcccgactt ggtcgggagg tcctccttgg cccagctgat ggctatacct ccaaggggtg     3420

gagtcttctc gcccccatca ctgcttacgc ccagcagaca cgtggccttt tgggcaccat     3480

agtggtgagc atgacggggc gcgacaagac agaacaggct ggggaaattc aggtcctgtc     3540

cacagtcact cagtccttcc tcggaacatc catctcgggg gttttgtgga ctgtctacca     3600

tggagctggc aacaagactc tggccggctc acggggtccg gtcacgcaga tgtactccag     3660

tgctgagggg gacttagtag ggtggcccag cccccctggg actaaatctt tggagccgtg     3720

cacgtgtgga gcggtcgacc tgtacctggt cacgcggaac gctgatgtca tcccggctcg     3780

aagacgcggg gacaaacggg gagcgctact ctccccgaga cctctttcca ccttgaaggg     3840

gtcctcagga ggcccggtgc tatgccccag gggccacgct gtcggagtct tccgggcagc     3900

tgtgtgctct cggggcgtgg ctaagtccat agatttcatc cccgttgaga cactcgacat     3960

cgtcacgcgg tcccccacct ttagtgacaa cagcacacca cctgctgtgc cccagaccta     4020

tcaggtcggg tacttgcatg ccccgactgg cagtggaaag agcaccaaag ttcctgtcgc     4080

atatgctgct caggggtata aagtgctagt gcttaatccc tcagtggctg ccaccctggg     4140

gtttggggcg tacttgtcta aggcacatgg catcaatccc aacattagga ctggagtcag     4200

gactgtgacg accggggcgc ccatcacgta ctccacatat ggcaaattcc tcgccgatgg     4260

gggctgtgcg ggcggcgcct acgacatcat catatgtgat gaatgccatg ccgtggactc     4320

taccaccatc cttggcatcg gaacagtcct tgatcaagca gagacagctg gggtcagact     4380

aactgtgctg gctacagcta cgccccctgg gtcagtgaca accccccacc ccaacataga     4440

ggaggtggcc cttgggcagg agggcgagat ccccttctat gggagggcga ttcccctgtc     4500

ttacatcaag ggaggaagac atctgatctt ctgccattca aagaaaaagt gtgacgagct     4560

cgcggcggcc cttcggggta tgggcttgaa ctcagtggca tactacagag ggttggacgt     4620

ctccgtaata ccaactcagg gagacgtagt ggtcgtcgcc accgacgccc tcatgacagg     4680

gtatactggg gactttgact ccgtgatcga ctgcaacgta gcggtcactc aagttgtaga     4740

cctcagttta gaccccacat tcaccataac cacacagatt gtccctcaag acgctgtctc     4800

acgtagccag cgccggggtc gcacgggtag gggaagactg ggcatttata ggtatgtttc     4860

cactggtgag cgagcctcag gaatgtttga cagtgtagtg ctctgtgagt gctacgacgc     4920

aggggccgca tggtatgagc tcacaccatc ggagaccacc gtcaggctca gggcgtattt     4980

caacacgccc ggtttgcctg tgtgccaaga ccatcttgag ttttgggagg cagttttcac     5040

cggcctcaca cacatagatg cccacttcct ttcccaaaca aagcaatcgg gggaaaattt     5100

cgcatactta acagcctacc aggctacagt gtgcgctagg gccaaagccc cccccccgtc     5160

ctgggacgtc atgtggaagt gtttgactcg actcaagccc acactcgtgg gccccacacc     5220

tctcctgtac cgcttgggct ctgttaccaa cgaggtcacc ctcacacatc ccgtgacgaa     5280

atacatcgcc acctgcatgc aagccgacct tgaggtcatg accagcacat gggtcttggc     5340

agggggagtc ttggcggccg tcgcctcgta ttgcctggcg accgggtgtg tttgcatcat     5400

cggccgcttg cacattaacc agcgagccgt cgttgcgccg gacaaggagg tcctctatga     5460

ggcttttgat gagatggagg aatgtgcctc tagggcggct ctcattgaag aggggcagcg     5520

gatagccgag atgctgaagt ccaagatcca aggcttattg cagcaagctt ccaaacaagc     5580

tcaagacata caacccactg tgcaggcttc atggcccaag gtagaacaat tctgggccaa     5640

acacatgtgg aacttcatta gcggcatcca atacctcgca ggactatcaa cactgccagg     5700

gaaccctgca gtagcttcca tgatggcgtt cagtgccgcc ctcaccagtc cgctgtcaac     5760

aagcaccact atccttctca acattttggg gggctggcta gcatcccaaa ttgcaccacc     5820

cgcgggggcc actggcttcg ttgtcagtgg cctagtggga gctgccgtag gcagtatagg     5880

cttaggtaag gtgctagtgg acatcctggc agggtatggt gcgggcattt cgggggctct     5940

cgtcgcattc aagatcatgt ctggcgagaa gccctccatg gaggatgtcg tcaacttgct     6000

gcctggaatt ctgtctccgg gtgccttggt agtgggagtc atctgcgcgg ccattctgcg     6060

ccgacacgtg ggaccggggg aaggcgccgt ccaatggatg aatagactca ttgcctttgc     6120

ttccagagga aatcacgtcg cccccaccca ctacgtgacg gagtcggatg cgtcgcagcg     6180

tgtgacccaa ctacttggct cccttaccat aaccagcctg ctcagaagac tccacaactg     6240

gattactgag gactgcccca tcccatgcgg cggctcgtgg ctccgcgatg tgtgggactg     6300

ggtttgcacc atcctaacag actttaaaaa ttggctgacc tccaaattat tcccaaagat     6360

gcccggcctc ccctttgtct cctgtcaaaa ggggtacaag ggcgtgtggg ccggcactgg     6420

catcatgacc acacggtgtc cttgcggcgc caatatctct ggcaatgtcc gcttgggctc     6480

catgagaatc acggggccta agacctgcat gaatatctgg caggggacct ttcctatcaa     6540

ttgttacacg gagggccagt gcgtgccgaa acccgcgcca aactttaagg tcgccatctg     6600

gagggtggcg gcctcagagt acgcggaggt gacgcagcac gggtcatacc actacataac     6660

aggactcacc actgataact tgaaagtccc ctgccaacta ccctctcccg agttcttttc     6720

ctgggtggac ggagtgcaga tccataggtt tgcccccaca ccgaagccgt ttttccggga     6780

tgaggtctcg ttctgcgttg ggcttaattc atttgtcgtc gggtcccagc ttccttgcga     6840

ccctgaaccc gacacagacg tattgatgtc catgctaaca gatccatctc atatcacggc     6900

ggagactgca gcgcggcgtt tagcgcgggg gtcaccccca tccgaggcaa gctcctcggc     6960

gagccagcta tcggcaccat cgctgcgagc cacctgcacc acccacggca aagcctatga     7020

tgtggacatg gtggatgcta acctgttcat ggggggcgat gtgactcgga tagagtctgg     7080

gtccaaagtg gtcgttctgg actctctcga cccaatggtc gaagaaagga gcgaccttga     7140

gccttcgata ccatcagaat acatgctccc caagaagagg ttcccaccag ctttaccggc     7200

ctgggcacgg cctgattaca acccaccgct tgtggaatcg tggaaaaggc cagattacca     7260

accggccact gttgcgggct gtgctctccc tcctcctagg aaaaccccga cgcctccccc     7320

aaggaggcgc cggacagtgg gcctaagtga ggactccata ggagatgccc ttcaacagct     7380

ggccattaag tcctttggcc agcccccccc aagcggcgat tcaggccttt ccacgggggc     7440

gggcgctgcc gattccggca gtcagacgcc tcctgatgag ttggcccttt cggagacagg     7500

ttccatctct tccatgcccc ccctcgaggg ggagcttgga gatccagacc tggagcctga     7560

gcaggtagag ccccaacccc ccccccaggg gggggtggca gctcccggct cggactcggg     7620

gtcctggtct acttgctccg aggaggacga ctccgtcgtg tgctgctcca tgtcatactc     7680

ctggaccggg gctctaataa ctccttgtag tcccgaagag gagaagttac cgattaaccc     7740

cttgagcaac tccctgttgc gatatcacaa caaggtgtac tgtaccacaa caaagagcgc     7800

ctcactaagg gctaaaaagg taacttttga taggatgcaa gtgctcgact cctactacga     7860

ctcagtctta aaggacatta agctagcggc ctccaaggtc accgcaaggc tcctcaccat     7920

ggaggaggct tgccagttaa ccccacccca ttctgcaaga tctaaatatg ggtttggggc     7980

taaggaggtc cgcagcttgt ccgggagggc cgttaaccac atcaagtccg tgtggaagga     8040

cctcctggag gactcagaaa caccaattcc cacaaccatt atggccaaaa atgaggtgtt     8100

ctgcgtggac cccaccaagg ggggcaagaa agcagctcgc cttatcgttt accctgacct     8160

cggcgtcagg gtctgcgaga agatggccct ttatgacatt acacaaaaac ttcctcaggc     8220

ggtgatgggg gcttcttatg gattccagta ttcccccgct cagcgggtag agtttctctt     8280

gaaagcatgg gcggaaaaga aggaccctat gggtttttcg tatgataccc gatgctttga     8340

ctcaaccgtc actgagagag acatcaggac tgaggagtcc atatatcggg cctgctcctt     8400

gcccgaggag gcccacactg ccatacactc gctaactgag agactttacg tgggagggcc     8460

tatgttcaac agcaagggcc aaacctgcgg gtacaggcgt tgccgcgcca gcggggtgct     8520

caccactagc atggggaaca ccatcacatg ctacgtgaaa gccttagcgg cttgtaaagc     8580

tgcagggata atcgcgccca caatgctggt atgcggcgat gacttggttg tcatctcaga     8640

aagccagggg accgaggagg acgagcggaa cctgagagcc ttcacggagg ctatgaccag     8700

gtattctgcc cctcctggtg acccccccag accggagtat gatctggagc tgataacatc     8760

ttgctcctca aatgtgtctg tggcgttggg cccgcggggc cgccgcagat actacctgac     8820

cagagaccca accactccac tcgcccgggc tgcctgggaa acagttagac actcccctat     8880

caattcatgg ctgggaaaca tcatccagta tgctccaacc atatgggttc gcatggtcct     8940

aatgacacac ttcttctcca ttctcatggt ccaagacacc ctggaccaga acctcaactt     9000

tgagatgtat ggatcagtat actccgtgaa tcctttggac cttccagcca taattgagag     9060

gttacacggg cttgacgcct tttctatgca cacatactct caccacgaac tgacgcgggt     9120

ggcttcagcc ctcagaaaac ttggggcgcc acccctcagg gtgtggaaga gtcgggctcg     9180

cgcagtcagg gcgtccctca tctcccgtgg agggaaagcg gccgtttgcg gccgatatct     9240

cttcaattgg gcggtgaaga ccaagctcaa actcactcca ttgccggagg cgcgcctact     9300

ggacttatcc agttggttca ccgtcggcgc cggcgggggc gacatttatc acagcgtgtc     9360

gcgtgcccga ccccgcttat tgctctttgg cctactccta ctttttgtag gggtaggcct     9420

tttcctactc cccgctcggt agagcggcac acattagcta cactccatag ctaactgtcc     9480

cttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     9540

tttttttttt tttttttttt tttttctttt tttctctttt ccttctttct taccttattt     9600

tactttcttt cctggtggct ccatcttagc cctagtcacg gctagctgtg aaaggtccgt     9660

gagccgcatg actgcagaga gtgccgtaac tggtctctct gcagatcatg t              9711


<210>  17
<211>  9711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  17
acccgcccct aataggggcg acactccgcc atgaatcact cccctgtgag gaactactgt       60

cttcacgcag aaagcgtcta gccatggcgt tagtatgagt gtcgtacagc ctccaggccc      120

ccccctcccg ggagagccat agtggtctgc ggaaccggtg agtacaccgg aattgccggg      180

aagactgggt cctttcttgg ataaacccac tctatgcccg gccatttggg cgtgcccccg      240

caagactgct agccgagtag cgttgggttg cgaaaggcct tgtggtactg cctgataggg      300

tgcttgcgag tgccccggga ggtctcgtag accgtgcacc atgagcacaa atcctaaacc      360

tcaaagaaaa accaaaagaa acaccaaccg tcgcccacaa gacgttaagt ttccgggcgg      420

cggccagatc gttggcggag tatacttgtt gccgcgcagg ggccccaggt tgggtgtgcg      480

cgcgacaagg aagacttcgg agcggtccca gccacgtgga aggcgccagc ccatccctaa      540

agatcggcgc tccactggca aatcctgggg aaaaccagga tacccctggc ccctatacgg      600

gaatgaggga ctcggctggg caggatggct cctgtccccc cgaggttccc gtccctcttg      660

gggccccaat gacccccggc ataggtcgcg caacgtgggt aaggtcatcg ataccctaac      720

gtgcggcttt gccgacctca tggggtacat ccctgtcgtg ggcgccccgc tcggcggcgt      780

cgccagagct ctcgcgcatg gcgtgagagt cctggaggac ggggttaatt ttgcaacagg      840

gaacttaccc ggttgctcct tttctatctt cttgctggcc ctgctgtcct gcatcaccac      900

cccggtctcc gctgccgaag tgaagaacat cagtaccggc tacatggtga ctaacgactg      960

caccaatgac agcattacct ggcagctcca ggctgctgtc ctccacgtcc ccgggtgcgt     1020

cccgtgcgag aaagtgggga atgcatctca gtgctggata ccggtctcac cgaatgtggc     1080

cgtgcagcgg cccggcgccc tcacgcaggg cttgcggacg cacatcgaca tggttgtgat     1140

gtccgccacg ctctgctctg ccctctacgt gggggacctc tgcggtgggg tgatgctcgc     1200

agcccaaatg ttcattgtct cgccgcagca ccactggttt gtccaagact gcaattgctc     1260

catctaccct ggtaccatca ctggacaccg catggcatgg gacatgatga tgaactggtc     1320

gcccacggct accatgatct tggcgtacgc gatgcgtgtc cccgaggtca ttatagacat     1380

cattagcggg gctcattggg gcgtcatgtt cggcttggcc tacttctcta tgcagggagc     1440

gtgggcgaaa gtcgttgtca tccttctgtt ggccgccggg gtggacgcgc gcacccatac     1500

tgttgggggt tctgccgcgc agaccaccgg gcgcctcacc agcttatttg acatgggccc     1560

caggcagaaa atccagctcg ttaacaccaa tggcagctgg cacatcaacc gcaccgccct     1620

gaactgcaat gactccttgc acaccggctt tatcgcgtct ctgttctaca cccacagctt     1680

caactcgtca ggatgtcccg aacgcatgtc cgcctgccgc agtatcgagg ccttccgggt     1740

gggatggggc gccttgcaat atgaggataa tgtcaccaat ccagaggata tgagacccta     1800

ttgctggcac tacccaccaa ggcagtgtgg cgtggtctcc gcgaagactg tgtgtggccc     1860

agtgtactgt ttcaccccca gcccagtggt agtgggcacg accgacaggc ttggagcgcc     1920

cacttacacg tggggggaga atgagacaga tgtcttccta ttgaacagca ctcgaccacc     1980

gctggggtca tggttcggct gcacgtggat gaactcttct ggctacacca agacttgcgg     2040

cgcaccaccc tgccgtacta gagctgactt caacgccagc acggacctgt tgtgccccac     2100

ggactgtttt aggaagcatc ctgataccac ttacctcaaa tgcggctctg ggccctggct     2160

cacgccaagg tgcctgatcg actaccccta caggctctgg cattacccct gcacagttaa     2220

ctataccatc ttcaaaataa ggatgtatgt gggaggggtt gagcacaggc tcacggctgc     2280

atgcaatttc actcgtgggg atcgttgcaa cttggaggac agagacagaa gtcaactgtc     2340

tcctttgttg cactccacca cggaatgggc cattttacct tgctcttact cggacctgcc     2400

cgccttgtcg actggtcttc tccacctcca ccaaaacatc gtggacgtac aattcatgta     2460

tggcctatca cctgccctca caaaatacat cgtccgatgg gagtgggtaa tactcttatt     2520

cctgctctta gcggacgcca gggtttgcgc ctgcttatgg atgctcatct tgttgggcca     2580

ggccgaagca gcactagaga agctggtcat cttgcacgct gcgagcgcag ctagctgcaa     2640

tggcttccta tattttgtca tcttttccgt ggctgcttgg tacatcaagg gtcgggtagt     2700

ccccttagct acctattccc tcactggcct gtggtccttt agcctactgc tcctagcatt     2760

gccccaacag gcttatgctt atgacgcatc tgtgcatggc cagataggag cggctctgct     2820

ggtaatgatc actctcttta ctctcacccc cgggtataag acccttctca gccggttttt     2880

gtggtggttg tgctatcttc tgaccctggg ggaagctatg gtccaggagt gggcaccacc     2940

tatgcaggtg cgcggtggcc gtgatggcat catatgggcc gtcgccatat tctacccagg     3000

tgtggtgttt gacataacca agtggctctt ggcggtgctt gggcctgctt acctcctaaa     3060

aggtgctttg acgcgcgtgc cgtacttcgt cagggctcac gctctactga ggatgtgcac     3120

catggcaagg catctcgcgg ggggcaggta cgtccagatg gcgctactag cccttggcag     3180

gtggactggc acttacatct atgaccacct cacccctatg tcggattggg ctgctagtgg     3240

cctgcgggac ctggcggtcg ccgttgagcc tatcatcttc agtccgatgg agaagaaagt     3300

cattgtctgg ggagcggaga cagctgcttg tggggacatt ttacacggac ttcccgtgtc     3360

cgcccgactt ggtcgggagg tcctccttgg cccagctgat ggctatacct ccaaggggtg     3420

gagtcttctc gcccccatca ctgcttacgc ccagcagaca cgtggccttt tgggcaccat     3480

agtggtgagc atgacggggc gcgacaagac agaacaggct ggggaaattc aggtcctgtc     3540

cacagtcact cagtccttcc tcggaacatc catctcgggg gttttgtgga ctgtctacca     3600

tggagctggc aacaagactc tggccggctc acggggtccg gtcacgcaga tgtactccag     3660

tgctgagggg gacttagtag ggtggcccag cccccctggg actaaatctt tggagccgtg     3720

cacgtgtgga gcggtcgacc tgtacctggt cacgcggaac gctgatgtca tcccggctcg     3780

aagacgcggg gacaaacggg gagcgctact ctccccgaga cctctttcca ccttgaaggg     3840

gtcctcagga ggcccggtgc tatgccccag gggccacgct gtcggagtct tccgggcagc     3900

tgtgtgctct cggggcgtgg ctaagtccat agatttcatc cccgttgaga cactcgacat     3960

cgtcacgcgg tcccccacct ttagtgacaa cagcacacca cctgctgtgc cccagaccta     4020

tcaggtcggg tacttgcatg ccccgactgg cagtggaaag agcaccaaag ttcctgtcgc     4080

atatgctgct caggggtata aagtgctagt gcttaatccc tcagtggctg ccaccctggg     4140

gtttggggcg tacttgtcta aggcacatgg catcaatccc aacattagga ctggagtcag     4200

gactgtgacg accggggcgc ccatcacgta ctccacatat ggcaaattcc tcgccgatgg     4260

gggctgtgcg ggcggcgcct acgacatcat catatgtgat gaatgccatg ccgtggactc     4320

taccaccatc cttggcatcg gaacagtcct tgatcaagca gagacagctg gggtcagact     4380

aactgtgctg gctacagcta cgccccctgg gtcagtgaca accccccacc ccaacataga     4440

ggaggtggcc cttgggcagg agggcgagat ccccttctat gggagggcga ttcccctgtc     4500

ttacatcaag ggaggaagac atctgatctt ctgccattca aagaaaaagt gtgacgagct     4560

cgcggcggcc cttcggggta tgggcttgaa ctcagtggca tactacagag ggttggacgt     4620

ctccgtaata ccaactcagg gagacgtagt ggtcgtcgcc accgacgccc tcatgacagg     4680

gtatactggg gactttgact ccgtgatcga ctgcaacgta gcggtcactc aagttgtaga     4740

cctcagttta gaccccacat tcaccataac cacacagatt gtccctcaag acgctgtctc     4800

acgtagccag cgccggggtc gcacgggtag gggaagactg ggcatttata ggtatgtttc     4860

cactggtgag cgagcctcag gaatgtttga cagtgtagtg ctctgtgagt gctacgacgc     4920

aggggccgca tggtatgagc tcacaccatc ggagaccacc gtcaggctca gggcgtattt     4980

caacacgccc ggtttgcctg tgtgccaaga ccatcttgag ttttgggagg cagttttcac     5040

cggcctcaca cacatagatg cccacttcct ttcccaaaca aagcaatcgg gggaaaattt     5100

cgcatactta acagcctacc aggctacagt gtgcgctagg gccaaagccc cccccccgtc     5160

ctgggacgtc atgtggaagt gtttgactcg actcaagccc acactcgtgg gccccacacc     5220

tctcctgtac cgcttgggct ctgttaccaa cgaggtcacc ctcacacatc ccgtgacgaa     5280

atacatcgcc acctgcatgc aagccgacct tgaggtcatg accagcacat gggtcttggc     5340

agggggagtc ttggcggccg tcgcctcgta ttgcctggcg accgggtgtg tttgcatcat     5400

cggccgcttg cacattaacc agcgagccgt cgttgcgccg gacaaggagg tcctctatga     5460

ggcttttgat gagatggagg aatgtgcctc tagggcggct ctcattgaag aggggcagcg     5520

gatagccgag atgctgaagt ccaagatcca aggcttattg cagcaagctt ccaaacaagc     5580

tcaagacata caacccactg tgcaggcttc atggcccaag gtagaacaat tctgggccaa     5640

acacatgtgg aacttcatta gcggcatcca atacctcgca ggactatcaa cactgccagg     5700

gaaccctgca gtagcttcca tgatggcgtt cagtgccgcc ctcaccagtc cgctgtcaac     5760

aagcaccact atccttctca acattttggg gggctggcta gcatcccaaa ttgcaccacc     5820

cgcgggggcc actggcttcg ttgtcagtgg cctagtggga gctgccgtag gcagtatagg     5880

cttaggtaag gtgctagtgg acatcctggc agggtatggt gcgggcattt cgggggctct     5940

cgtcgcattc aagatcatgt ctggcgagaa gccctccatg gaggatgtcg tcaacttgct     6000

gcctggaatt ctgtctccgg gtgccttggt agtgggagtc atctgcgcgg ccattctgcg     6060

ccgacacgtg ggaccggggg aaggcgccgt ccaatggatg aatagactca ttgcctttgc     6120

ttccagagga aatcacgtcg cccccaccca ctacgtgacg gagtcggatg cgtcgcagcg     6180

tgtgacccaa ctacttggct cccttaccat aaccagcctg ctcagaagac tccacaactg     6240

gattactgag gactgcccca tcccatgcgg cggctcgtgg ctccgcgatg tgtgggactg     6300

ggtttgcacc atcctaacag actttaaaaa ttggctgacc tccaaattat tcccaaagat     6360

gcccggcctc ccctttgtct cctgtcaaaa ggggtacaag ggcgtgtggg ccggcactgg     6420

catcatgacc acacggtgtc cttgcggcgc caatatctct ggcaatgtcc gcttgggctc     6480

catgagaatc acggggccta agacctgcat gaatatctgg caggggacct ttcctatcaa     6540

ttgttacacg gagggccagt gcgtgccgaa acccgcgcca aactttaagg tcgccatctg     6600

gagggtggcg gcctcagagt acgcggaggt gacgcagcac gggtcatacc actacataac     6660

aggactcacc actgataact tgaaagtccc ctgccaacta ccctctcccg agttcttttc     6720

ctgggtggac ggagtgcaga tccataggtt tgcccccaca ccgaagccgt ttttccggga     6780

tgaggtctcg ttctgcgttg ggcttaattc atttgtcgtc gggtcccagc ttccttgcga     6840

ccctgaaccc gacacagacg tattgatgtc catgctaaca gatccatctc atatcacggc     6900

ggagactgca gcgcggcgtt tagcgcgggg gtcaccccca tccgaggcaa gctcctcggc     6960

gagccagcta tcggcaccat cgctgcgagc cacctgcacc acccacggca aagcctatga     7020

tgtggacatg gtggatgcta acctgttcat ggggggcgat gtgactcgga tagagtctgg     7080

gtccaaagtg gtcgttctgg actctctcga cccaatggtc gaagaaagga gcgaccttga     7140

gccttcgata ccatcagaat acatgctccc caagaagagg ttcccaccag ctttaccggc     7200

ctgggcacgg cctgattaca acccaccgct tgtggaatcg tggaaaaggc cagattacca     7260

accggccact gttgcgggct gtgctctccc tcctcctagg aaaaccccga cgcctccccc     7320

aaggaggcgc cggacagtgg gcctaagtga ggactccata ggagatgccc ttcaacagct     7380

ggccattaag tcctttggcc agcccccccc aagcggcgat tcaggccttt ccacgggggc     7440

gggcgctgcc gattccggca gtcagacgcc tcctgatgag ttggcccttt cggagacagg     7500

ttccatctct tccatgcccc ccctcgaggg ggagcttgga gatccagacc tggagcctga     7560

gcaggtagag ccccaacccc ccccccaggg gggggtggca gctcccggct cggactcggg     7620

gtcctggtct acttgctccg aggaggacga ctccgtcgtg tgctgctcca tgtcatactc     7680

ctggaccggg gctctaataa ctccttgtag tcccgaagag gagaagttac cgattaaccc     7740

cttgagcaac tccctgttgc gatatcacaa caaggtgtac tgtaccacaa caaagagcgc     7800

ctcactaagg gctaaaaagg taacttttga taggatgcaa gtgctcgact cctactacga     7860

ctcagtctta aaggacatta agctagcggc ctccaaggtc accgcaaggc tcctcaccat     7920

ggaggaggct tgccagttaa ccccacccca ttctgcaaga tctaaatatg ggtttggggc     7980

taaggaggtc cgcagcttgt ccgggagggc cgttaaccac atcaagtccg tgtggaagga     8040

cctcctggag gactcagaaa caccaattcc cacaaccatt atggccaaaa atgaggtgtt     8100

ctgcgtggac cccaccaagg ggggcaagaa agcagctcgc cttatcgttt accctgacct     8160

cggcgtcagg gtctgcgaga agatggccct ttatgacatt acacaaaaac ttcctcaggc     8220

ggtgatgggg gcttcttatg gattccagta ttcccccgct cagcgggtag agtttctctt     8280

gaaagcatgg gcggaaaaga aggaccctat gggtttttcg tatgataccc gatgctttga     8340

ctcaaccgtc actgagagag acatcaggac tgaggagtcc atatatcggg cctgctcctt     8400

gcccgaggag gcccacactg ccatacactc gctaactgag agactttacg tgggagggcc     8460

tatgttcaac agcaagggcc aaacctgcgg gtacaggcgt tgccgcgcca gcggggtgct     8520

caccactagc atggggaaca ccatcacatg ctacgtgaaa gccttagcgg cttgtaaagc     8580

tgcagggata atcgcgccca caatgctggt atgcggcgat gacttggttg tcatctcaga     8640

aagccagggg accgaggagg acgagcggaa cctgagagcc ttcacggagg ctatgaccag     8700

gtattctgcc cctcctggtg acccccccag accggagtat gatctggagc tgataacatc     8760

ttgctcctca aatgtgtctg tggcgctggg cccacaaggc cgccgcagat actacctgac     8820

cagagaccct accactccaa tcgcccgggc tgcctgggaa acagttagac actcccctgt     8880

caattcatgg ctgggaaaca tcatccagta cgccccgacc atatgggctc gcatggtcct     8940

gatgacacac ttcttctcca ttctcatggc tcaagacacg ctggaccaga acctcaactt     9000

tgagatgtac ggagcggtgt actccgtgag tcccttggac ctcccagcta taattgaaag     9060

gttacacggg cttgacgcct tttctatgca cacatactct caccacgaac tgacgcgggt     9120

ggcttcagcc ctcagaaaac ttggggcgcc acccctcagg gtgtggaaga gtcgggctcg     9180

cgcagtcagg gcgtccctca tctcccgtgg agggaaagcg gccgtttgcg gccgatatct     9240

cttcaattgg gcggtgaaga ccaagctcaa actcactcca ttgccggagg cgcgcctact     9300

ggacttatcc agttggttca ccgtcggcgc cggcgggggc gacatttttc acagcgtgtc     9360

gcgcgcccga ccccgctcat tactcttcgg cctactccta cttttcgtag gggtaggcct     9420

cttcctactc cccgctcggt agagcggcac acattagcta cactccatag ctaactgtcc     9480

cttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     9540

tttttttttt tttttttttt tttttctttt tttctctttt ccttctttct taccttattt     9600

tactttcttt cctggtggct ccatcttagc cctagtcacg gctagctgtg aaaggtccgt     9660

gagccgcatg actgcagaga gtgccgtaac tggtctctct gcagatcatg t              9711


<210>  18
<211>  9696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  18
acccgcccct aataggggcg acactccgcc atgaatcact cccctgtgag gaactactgt       60

cttcacgcag aaagcgtcta gccatggcgt tagtatgagt gtcgtacagc ctccaggccc      120

ccccctcccg ggagagccat agtggtctgc ggaaccggtg agtacaccgg aattgccggg      180

aagactgggt cctttcttgg ataaacccac tctatgcccg gccatttggg cgtgcccccg      240

caagactgct agccgagtag cgttgggttg cgaaaggcct tgtggtactg cctgataggg      300

tgcttgcgag tgccccggga ggtctcgtag accgtgcacc atgagcacaa atcctaaacc      360

tcaaagaaaa accaaaagaa acaccaaccg tcgcccacaa gacgttaagt ttccgggcgg      420

cggccagatc gttggcggag tatacttgtt gccgcgcagg ggccccaggt tgggtgtgcg      480

cgcgacaagg aagacttcgg agcggtccca gccacgtgga aggcgccagc ccatccctaa      540

agatcggcgc tccactggca aatcctgggg aaaaccagga tacccctggc ccctatacgg      600

gaatgaggga ctcggctggg caggatggct cctgtccccc cgaggttccc gtccctcttg      660

gggccccaat gacccccggc ataggtcgcg caacgtgggt aaggtcatcg ataccctaac      720

gtgcggcttt gccgacctca tggggtacat ccctgtcgtg ggcgccccgc tcggcggcgt      780

cgccagagct ctcgcgcatg gcgtgagagt cctggaggac ggggttaatt ttgcaacagg      840

gaacttaccc ggttgctcct tttctatctt cttgctggcc ctgctgtcct gcatcaccac      900

cccggtctcc gctgccgaag tgaagaacat cagtaccggc tacatggtga ctaacgactg      960

caccaatgac agcattacct ggcagctcca ggctgctgtc ctccacgtcc ccgggtgcgt     1020

cccgtgcgag aaagtgggga atgcatctca gtgctggata ccggtctcac cgaatgtggc     1080

cgtgcagcgg cccggcgccc tcacgcaggg cttgcggacg cacatcgaca tggttgtgat     1140

gtccgccacg ctctgctctg ccctctacgt gggggacctc tgcggtgggg tgatgctcgc     1200

agcccaaatg ttcattgtct cgccgcagca ccactggttt gtccaagact gcaattgctc     1260

catctaccct ggtaccatca ctggacaccg catggcatgg gacatgatga tgaactggtc     1320

gcccacggct accatgatct tggcgtacgc gatgcgtgtc cccgaggtca ttatagacat     1380

cattagcggg gctcattggg gcgtcatgtt cggcttggcc tacttctcta tgcagggagc     1440

gtgggcgaaa gtcgttgtca tccttctgtt ggccgccggg gtggacgcgc gcacccatac     1500

tgttgggggt tctgccgcgc agaccaccgg gcgcctcacc agcttatttg acatgggccc     1560

caggcagaaa atccagctcg ttaacaccaa tggcagctgg cacatcaacc gcaccgccct     1620

gaactgcaat gactccttgc acaccggctt tatcgcgtct ctgttctaca cccacagctt     1680

caactcgtca ggatgtcccg aacgcatgtc cgcctgccgc agtatcgagg ccttccgggt     1740

gggatggggc gccttgcaat atgaggataa tgtcaccaat ccagaggata tgagacccta     1800

ttgctggcac tacccaccaa ggcagtgtgg cgtggtctcc gcgaagactg tgtgtggccc     1860

agtgtactgt ttcaccccca gcccagtggt agtgggcacg accgacaggc ttggagcgcc     1920

cacttacacg tggggggaga atgagacaga tgtcttccta ttgaacagca ctcgaccacc     1980

gctggggtca tggttcggct gcacgtggat gaactcttct ggctacacca agacttgcgg     2040

cgcaccaccc tgccgtacta gagctgactt caacgccagc acggacctgt tgtgccccac     2100

ggactgtttt aggaagcatc ctgataccac ttacctcaaa tgcggctctg ggccctggct     2160

cacgccaagg tgcctgatcg actaccccta caggctctgg cattacccct gcacagttaa     2220

ctataccatc ttcaaaataa ggatgtatgt gggaggggtt gagcacaggc tcacggctgc     2280

atgcaatttc actcgtgggg atcgttgcaa cttggaggac agagacagaa gtcaactgtc     2340

tcctttgttg cactccacca cggaatgggc cattttacct tgctcttact cggacctgcc     2400

cgccttgtcg actggtcttc tccacctcca ccaaaacatc gtggacgtac aattcatgta     2460

tggcctatca cctgccctca caaaatacat cgtccgatgg gagtgggtaa tactcttatt     2520

cctgctctta gcggacgcca gggtttgcgc ctgcttatgg atgctcatct tgttgggcca     2580

ggccgaagca gcactagaga agctggtcat cttgcacgct gcgagcgcag ctagctgcaa     2640

tggcttccta tattttgtca tcttttccgt ggctgcttgg tacatcaagg gtcgggtagt     2700

ccccttagct acctattccc tcactggcct gtggtccttt agcctactgc tcctagcatt     2760

gccccaacag gcttatgctt atgacgcatc tgtgcatggc cagataggag cggctctgct     2820

ggtaatgatc actctcttta ctctcacccc cgggtataag acccttctca gccggttttt     2880

gtggtggttg tgctatcttc tgaccctggg ggaagctatg gtccaggagt gggcaccacc     2940

tatgcaggtg cgcggtggcc gtgatggcat catatgggcc gtcgccatat tctacccagg     3000

tgtggtgttt gacataacca agtggctctt ggcggtgctt gggcctgctt acctcctaaa     3060

aggtgctttg acgcgcgtgc cgtacttcgt cagggctcac gctctactga ggatgtgcac     3120

catggcaagg catctcgcgg ggggcaggta cgtccagatg gcgctactag cccttggcag     3180

gtggactggc acttacatct atgaccacct cacccctatg tcggattggg ctgctagtgg     3240

cctgcgggac ctggcggtcg ccgttgagcc tatcatcttc agtccgatgg agaagaaagt     3300

cattgtctgg ggagcggaga cagctgcttg tggggacatt ttacacggac ttcccgtgtc     3360

cgcccgactt ggtcgggagg tcctccttgg cccagctgat ggctatacct ccaaggggtg     3420

gagtcttctc gcccccatca ctgcttacgc ccagcagaca cgtggccttt tgggcaccat     3480

agtggtgagc atgacggggc gcgacaagac agaacaggct ggggaaattc aggtcctgtc     3540

cacagtcact cagtccttcc tcggaacatc catctcgggg gttttgtgga ctgtctacca     3600

tggagctggc aacaagactc tggccggctc acggggtccg gtcacgcaga tgtactccag     3660

tgctgagggg gacttagtag ggtggcccag cccccctggg actaaatctt tggagccgtg     3720

cacgtgtgga gcggtcgacc tgtacctggt cacgcggaac gctgatgtca tcccggctcg     3780

aagacgcggg gacaaacggg gagcgctact ctccccgaga cctctttcca ccttgaaggg     3840

gtcctcagga ggcccggtgc tatgccccag gggccacgct gtcggagtct tccgggcagc     3900

tgtgtgctct cggggcgtgg ctaagtccat agatttcatc cccgttgaga cactcgacat     3960

cgtcacgcgg tcccccacct ttagtgacaa cagcacacca cctgctgtgc cccagaccta     4020

tcaggtcggg tacttgcatg ccccgactgg cagtggaaag agcaccaaag ttcctgtcgc     4080

atatgctgct caggggtata aagtgctagt gcttaatccc tcagtggctg ccaccctggg     4140

gtttggggcg tacttgtcta aggcacatgg catcaatccc aacattagga ctggagtcag     4200

gactgtgacg accggggcgc ccatcacgta ctccacatat ggcaaattcc tcgccgatgg     4260

gggctgtgcg ggcggcgcct acgacatcat catatgtgat gaatgccatg ccgtggactc     4320

taccaccatc cttggcatcg gaacagtcct tgatcaagca gagacagctg gggtcagact     4380

aactgtgctg gctacagcta cgccccctgg gtcagtgaca accccccacc ccaacataga     4440

ggaggtggcc cttgggcagg agggcgagat ccccttctat gggagggcga ttcccctgtc     4500

ttacatcaag ggaggaagac atctgatctt ctgccattca aagaaaaagt gtgacgagct     4560

cgcggcggcc cttcggggta tgggcttgaa ctcagtggca tactacagag ggttggacgt     4620

ctccgtaata ccaactcagg gagacgtagt ggtcgtcgcc accgacgccc tcatgacagg     4680

gtatactggg gactttgact ccgtgatcga ctgcaacgta gcggtcactc aagttgtaga     4740

cctcagttta gaccccacat tcaccataac cacacagatt gtccctcaag acgctgtctc     4800

acgtagccag cgccggggtc gcacgggtag gggaagactg ggcatttata ggtatgtttc     4860

cactggtgag cgagcctcag gaatgtttga cagtgtagtg ctctgtgagt gctacgacgc     4920

aggggccgca tggtatgagc tcacaccatc ggagaccacc gtcaggctca gggcgtattt     4980

caacacgccc ggtttgcctg tgtgccaaga ccatcttgag ttttgggagg cagttttcac     5040

cggcctcaca cacatagatg cccacttcct ttcccaaaca aagcaatcgg gggaaaattt     5100

cgcatactta acagcctacc aggctacagt gtgcgctagg gccaaagccc cccccccgtc     5160

ctgggacgtc atgtggaagt gtttgactcg actcaagccc acactcgtgg gccccacacc     5220

tctcctgtac cgcttgggct ctgttaccaa cgaggtcacc ctcacacatc ccgtgacgaa     5280

atacatcgcc acctgcatgc aagccgacct tgaggtcatg accagcacat gggtcttggc     5340

agggggagtc ttggcggccg tcgcctcgta ttgcctggcg accgggtgtg tttgcatcat     5400

cggccgcttg cacattaacc agcgagccgt cgttgcgccg gacaaggagg tcctctatga     5460

ggcttttgat gagatggagg aatgtgcctc tagggcggct ctcattgaag aggggcagcg     5520

gatagccgag atgctgaagt ccaagatcca aggcttattg cagcaagctt ccaaacaagc     5580

tcaagacata caacccactg tgcaggcttc atggcccaag gtagaacaat tctgggccaa     5640

acacatgtgg aacttcatta gcggcatcca atacctcgca ggactatcaa cactgccagg     5700

gaaccctgca gtagcttcca tgatggcgtt cagtgccgcc ctcaccagtc cgctgtcaac     5760

aagcaccact atccttctca acattttggg gggctggcta gcatcccaaa ttgcaccacc     5820

cgcgggggcc actggcttcg ttgtcagtgg cctagtggga gctgccgtag gcagtatagg     5880

cttaggtaag gtgctagtgg acatcctggc agggtatggt gcgggcattt cgggggctct     5940

cgtcgcattc aagatcatgt ctggcgagaa gccctccatg gaggatgtcg tcaacttgct     6000

gcctggaatt ctgtctccgg gtgccttggt agtgggagtc atctgcgcgg ccattctgcg     6060

ccgacacgtg ggaccggggg aaggcgccgt ccaatggatg aatagactca ttgcctttgc     6120

ttccagagga aatcacgtcg cccccaccca ctacgtgacg gagtcggatg cgtcgcagcg     6180

tgtgacccaa ctacttggct cccttaccat aaccagcctg ctcagaagac tccacaactg     6240

gattactgag gactgcccca tcccatgcgg cggctcgtgg ctccgcgatg tgtgggactg     6300

ggtttgcacc atcctaacag actttaaaaa ttggctgacc tccaaattat tcccaaagat     6360

gcccggcctc ccctttgtct cctgtcaaaa ggggtacaag ggcgtgtggg ccggcactgg     6420

catcatgacc acacggtgtc cttgcggcgc caatatctct ggcaatgtcc gcttgggctc     6480

catgagaatc acggggccta agacctgcat gaatatctgg caggggacct ttcctatcaa     6540

ttgttacacg gagggccagt gcgtgccgaa acccgcgcca aactttaagg tcgccatctg     6600

gagggtggcg gcctcagagt acgcggaggt gacgcagcac gggtcatacc actacataac     6660

aggactcacc actgataact tgaaagtccc ctgccaacta ccctctcccg agttcttttc     6720

ctgggtggac ggagtgcaga tccataggtt tgcccccaca ccgaagccgt ttttccggga     6780

tgaggtctcg ttctgcgttg ggcttaattc atttgtcgtc gggtcccagc ttccttgcga     6840

ccctgaaccc gacacagacg tattgatgtc catgctaaca gatccatctc atatcacggc     6900

ggagactgca gcgcggcgtt tagcgcgggg gtcaccccca tccgaggcaa gctcctcggc     6960

gagccagcta tcggcaccat cgctgcgagc cacctgcacc acccacggca aagcctatga     7020

tgtggacatg gtggatgcta acctgttcat ggggggcgat gtgactcgga tagagtctgg     7080

gtccaaagtg gtcgttctgg actctctcga cccaatggtc gaagaaagga gcgaccttga     7140

gccttcgata ccatcagaat acatgctccc caagaagagg ttcccaccag ctttaccggc     7200

ctgggcacgg cctgattaca acccaccgct tgtggaatcg tggaaaaggc cagattacca     7260

accggccact gttgcgggct gtgctctccc tcctcctagg aaaaccccga cgcctccccc     7320

aaggaggcgc cggacagtgg gcctaagtga ggactccata ggagatgccc ttcaacagct     7380

ggccattaag tcctttggcc agcccccccc aagcggcgat tcaggccttt ccacgggggc     7440

gggcgctgcc gattccggca gtcagacgcc tcctgatgag ttggcccttt cggagacagg     7500

ttccatctct tccatgcccc ccctcgaggg ggagcttgga gatccagacc tggagcctga     7560

gcaggtagag ccccaacccc ccccccaggg gggggtggca gctcccggct cggactcggg     7620

gtcctggtct acttgctccg aggaggacga ctccgtcgtg tgctgctcca tgtcatactc     7680

ctggaccggg gctctaataa ctccttgtag tcccgaagag gagaagttac cgattaaccc     7740

cttgagcaac tccctgttgc gatatcacaa caaggtgtac tgtaccacaa caaagagcgc     7800

ctcactaagg gctaaaaagg taacttttga taggatgcaa gtgctcgact cctactacga     7860

ctcagtctta aaggacatta agctagcggc ctccaaggtc accgcaaggc tcctcaccat     7920

ggaggaggct tgccagttaa ccccacccca ttctgcaaga tctaaatatg ggtttggggc     7980

taaggaggtc cgcagcttgt ccgggagggc cgttaaccac atcaagtccg tgtggaagga     8040

cctcctggag gactcagaaa caccaattcc cacaaccatt atggccaaaa atgaggtgtt     8100

ctgcgtggac cccaccaagg ggggcaagaa agcagctcgc cttatcgttt accctgacct     8160

cggcgtcagg gtctgcgaga agatggccct ttatgacatt acacaaaaac ttcctcaggc     8220

ggtgatgggg gcttcttatg gattccagta ttcccccgct cagcgggtag agtttctctt     8280

gaaagcatgg gcggaaaaga aggaccctat gggtttttcg tatgataccc gatgctttga     8340

ctcaaccgtc actgagagag acatcaggac tgaggagtcc atatatcggg cctgctcctt     8400

gcccgaggag gcccacactg ccatacactc gctaactgag agactttacg tgggagggcc     8460

tatgttcaac agcaagggcc aaacctgcgg gtacaggcgt tgccgcgcca gcggggtgct     8520

caccactagc atggggaaca ccatcacatg ctacgtgaaa gccttagcgg cttgtaaagc     8580

tgcagggata atcgcgccca caatgctggt atgcggcgat gacttggttg tcatctcaga     8640

aagccagggg accgaggagg acgagcggaa cctgagagcc ttcacggagg ctatgaccag     8700

gtattctgcc cctcctggtg acccccccag accggagtat gatctggagc tgataacatc     8760

ttgctcctca aatgtgtctg tggcgctggg cccacaaggc cgccgcagat actacctgac     8820

cagagaccct accactccaa tcgcccgggc tgcctgggaa acagttagac actcccctgt     8880

caattcatgg ctgggaaaca tcatccagta cgccccgacc atatgggctc gcatggtcct     8940

gatgacacac ttcttctcca ttctcatggc tcaagacacg ctggaccaga acctcaactt     9000

tgagatgtac ggagcggtgt actccgtgag tcccttggac ctcccagcta taattgaaag     9060

gttacacggg cttgacgcct tttctatgca cacatactct caccacgaac tgacgcgggt     9120

ggcttcagcc ctcagaaaac ttggggcgcc acccctcagg gtgtggaaga gtcgggctcg     9180

cgcagtcagg gcgtccctca tctcccgtgg agggaaagcg gccgtttgcg gccgatatct     9240

cttcaattgg gcggtgaaga ccaagctcaa actcactcca ttgccggagg cgcgcctact     9300

ggacttatcc agttggttca ccgtcggcgc cggcgggggc gacatttatc acagcgtgtc     9360

gcgtgcccga ccccgcttat tgctctttgg cctactccta ctttttgtag gggtaggcct     9420

tttcctactc cccgctcggt agagcggcac acattagcta cactccatag ctaactgtcc     9480

cttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     9540

tttttttttt ctttttttct cttttccttc tttcttacct tattttactt tctttcctgg     9600

tggctccatc ttagccctag tcacggctag ctgtgaaagg tccgtgagcc gcatgactgc     9660

agagagtgcc gtaactggtc tctctgcaga tcatgt                               9696


<210>  19
<211>  9678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  19
acccgcccct aataggggcg acactccgcc atgaatcact cccctgtgag gaactactgt       60

cttcacgcag aaagcgtcta gccatggcgt tagtatgagt gtcgtacagc ctccaggccc      120

ccccctcccg ggagagccat agtggtctgc ggaaccggtg agtacaccgg aattgccggg      180

aagactgggt cctttcttgg ataaacccac tctatgcccg gccatttggg cgtgcccccg      240

caagactgct agccgagtag cgttgggttg cgaaaggcct tgtggtactg cctgataggg      300

tgcttgcgag tgccccggga ggtctcgtag accgtgcacc atgagcacaa atcctaaacc      360

tcaaagaaaa accaaaagaa acaccaaccg tcgcccacaa gacgttaagt ttccgggcgg      420

cggccagatc gttggcggag tatacttgtt gccgcgcagg ggccccaggt tgggtgtgcg      480

cgcgacaagg aagacttcgg agcggtccca gccacgtgga aggcgccagc ccatccctaa      540

agatcggcgc tccactggca aatcctgggg aaaaccagga tacccctggc ccctatacgg      600

gaatgaggga ctcggctggg caggatggct cctgtccccc cgaggttccc gtccctcttg      660

gggccccaat gacccccggc ataggtcgcg caacgtgggt aaggtcatcg ataccctaac      720

gtgcggcttt gccgacctca tggggtacat ccctgtcgtg ggcgccccgc tcggcggcgt      780

cgccagagct ctcgcgcatg gcgtgagagt cctggaggac ggggttaatt ttgcaacagg      840

gaacttaccc ggttgctcct tttctatctt cttgctggcc ctgctgtcct gcatcaccac      900

cccggtctcc gctgccgaag tgaagaacat cagtaccggc tacatggtga ctaacgactg      960

caccaatgac agcattacct ggcagctcca ggctgctgtc ctccacgtcc ccgggtgcgt     1020

cccgtgcgag aaagtgggga atgcatctca gtgctggata ccggtctcac cgaatgtggc     1080

cgtgcagcgg cccggcgccc tcacgcaggg cttgcggacg cacatcgaca tggttgtgat     1140

gtccgccacg ctctgctctg ccctctacgt gggggacctc tgcggtgggg tgatgctcgc     1200

agcccaaatg ttcattgtct cgccgcagca ccactggttt gtccaagact gcaattgctc     1260

catctaccct ggtaccatca ctggacaccg catggcatgg gacatgatga tgaactggtc     1320

gcccacggct accatgatct tggcgtacgc gatgcgtgtc cccgaggtca ttatagacat     1380

cattagcggg gctcattggg gcgtcatgtt cggcttggcc tacttctcta tgcagggagc     1440

gtgggcgaaa gtcgttgtca tccttctgtt ggccgccggg gtggacgcgc gcacccatac     1500

tgttgggggt tctgccgcgc agaccaccgg gcgcctcacc agcttatttg acatgggccc     1560

caggcagaaa atccagctcg ttaacaccaa tggcagctgg cacatcaacc gcaccgccct     1620

gaactgcaat gactccttgc acaccggctt tatcgcgtct ctgttctaca cccacagctt     1680

caactcgtca ggatgtcccg aacgcatgtc cgcctgccgc agtatcgagg ccttccgggt     1740

gggatggggc gccttgcaat atgaggataa tgtcaccaat ccagaggata tgagacccta     1800

ttgctggcac tacccaccaa ggcagtgtgg cgtggtctcc gcgaagactg tgtgtggccc     1860

agtgtactgt ttcaccccca gcccagtggt agtgggcacg accgacaggc ttggagcgcc     1920

cacttacacg tggggggaga atgagacaga tgtcttccta ttgaacagca ctcgaccacc     1980

gctggggtca tggttcggct gcacgtggat gaactcttct ggctacacca agacttgcgg     2040

cgcaccaccc tgccgtacta gagctgactt caacgccagc acggacctgt tgtgccccac     2100

ggactgtttt aggaagcatc ctgataccac ttacctcaaa tgcggctctg ggccctggct     2160

cacgccaagg tgcctgatcg actaccccta caggctctgg cattacccct gcacagttaa     2220

ctataccatc ttcaaaataa ggatgtatgt gggaggggtt gagcacaggc tcacggctgc     2280

atgcaatttc actcgtgggg atcgttgcaa cttggaggac agagacagaa gtcaactgtc     2340

tcctttgttg cactccacca cggaatgggc cattttacct tgctcttact cggacctgcc     2400

cgccttgtcg actggtcttc tccacctcca ccaaaacatc gtggacgtac aattcatgta     2460

tggcctatca cctgccctca caaaatacat cgtccgatgg gagtgggtaa tactcttatt     2520

cctgctctta gcggacgcca gggtttgcgc ctgcttatgg atgctcatct tgttgggcca     2580

ggccgaagca gcactagaga agctggtcat cttgcacgct gcgagcgcag ctagctgcaa     2640

tggcttccta tattttgtca tcttttccgt ggctgcttgg tacatcaagg gtcgggtagt     2700

ccccttagct acctattccc tcactggcct gtggtccttt agcctactgc tcctagcatt     2760

gccccaacag gcttatgctt atgacgcatc tgtgcatggc cagataggag cggctctgct     2820

ggtaatgatc actctcttta ctctcacccc cgggtataag acccttctca gccggttttt     2880

gtggtggttg tgctatcttc tgaccctggg ggaagctatg gtccaggagt gggcaccacc     2940

tatgcaggtg cgcggtggcc gtgatggcat catatgggcc gtcgccatat tctacccagg     3000

tgtggtgttt gacataacca agtggctctt ggcggtgctt gggcctgctt acctcctaaa     3060

aggtgctttg acgcgcgtgc cgtacttcgt cagggctcac gctctactga ggatgtgcac     3120

catggcaagg catctcgcgg ggggcaggta cgtccagatg gcgctactag cccttggcag     3180

gtggactggc acttacatct atgaccacct cacccctatg tcggattggg ctgctagtgg     3240

cctgcgggac ctggcggtcg ccgttgagcc tatcatcttc agtccgatgg agaagaaagt     3300

cattgtctgg ggagcggaga cagctgcttg tggggacatt ttacacggac ttcccgtgtc     3360

cgcccgactt ggtcgggagg tcctccttgg cccagctgat ggctatacct ccaaggggtg     3420

gagtcttctc gcccccatca ctgcttacgc ccagcagaca cgtggccttt tgggcaccat     3480

agtggtgagc atgacggggc gcgacaagac agaacaggct ggggaaattc aggtcctgtc     3540

cacagtcact cagtccttcc tcggaacatc catctcgggg gttttgtgga ctgtctacca     3600

tggagctggc aacaagactc tggccggctc acggggtccg gtcacgcaga tgtactccag     3660

tgctgagggg gacttagtag ggtggcccag cccccctggg actaaatctt tggagccgtg     3720

cacgtgtgga gcggtcgacc tgtacctggt cacgcggaac gctgatgtca tcccggctcg     3780

aagacgcggg gacaaacggg gagcgctact ctccccgaga cctctttcca ccttgaaggg     3840

gtcctcagga ggcccggtgc tatgccccag gggccacgct gtcggagtct tccgggcagc     3900

tgtgtgctct cggggcgtgg ctaagtccat agatttcatc cccgttgaga cactcgacat     3960

cgtcacgcgg tcccccacct ttagtgacaa cagcacacca cctgctgtgc cccagaccta     4020

tcaggtcggg tacttgcatg ccccgactgg cagtggaaag agcaccaaag ttcctgtcgc     4080

atatgctgct caggggtata aagtgctagt gcttaatccc tcagtggctg ccaccctggg     4140

gtttggggcg tacttgtcta aggcacatgg catcaatccc aacattagga ctggagtcag     4200

gactgtgacg accggggcgc ccatcacgta ctccacatat ggcaaattcc tcgccgatgg     4260

gggctgtgcg ggcggcgcct acgacatcat catatgtgat gaatgccatg ccgtggactc     4320

taccaccatc cttggcatcg gaacagtcct tgatcaagca gagacagctg gggtcagact     4380

aactgtgctg gctacagcta cgccccctgg gtcagtgaca accccccacc ccaacataga     4440

ggaggtggcc cttgggcagg agggcgagat ccccttctat gggagggcga ttcccctgtc     4500

ttacatcaag ggaggaagac atctgatctt ctgccattca aagaaaaagt gtgacgagct     4560

cgcggcggcc cttcggggta tgggcttgaa ctcagtggca tactacagag ggttggacgt     4620

ctccgtaata ccaactcagg gagacgtagt ggtcgtcgcc accgacgccc tcatgacagg     4680

gtatactggg gactttgact ccgtgatcga ctgcaacgta gcggtcactc aagttgtaga     4740

cctcagttta gaccccacat tcaccataac cacacagatt gtccctcaag acgctgtctc     4800

acgtagccag cgccggggtc gcacgggtag gggaagactg ggcatttata ggtatgtttc     4860

cactggtgag cgagcctcag gaatgtttga cagtgtagtg ctctgtgagt gctacgacgc     4920

aggggccgca tggtatgagc tcacaccatc ggagaccacc gtcaggctca gggcgtattt     4980

caacacgccc ggtttgcctg tgtgccaaga ccatcttgag ttttgggagg cagttttcac     5040

cggcctcaca cacatagatg cccacttcct ttcccaaaca aagcaatcgg gggaaaattt     5100

cgcatactta acagcctacc aggctacagt gtgcgctagg gccaaagccc cccccccgtc     5160

ctgggacgtc atgtggaagt gtttgactcg actcaagccc acactcgtgg gccccacacc     5220

tctcctgtac cgcttgggct ctgttaccaa cgaggtcacc ctcacacatc ccgtgacgaa     5280

atacatcgcc acctgcatgc aagccgacct tgaggtcatg accagcacat gggtcttggc     5340

agggggagtc ttggcggccg tcgcctcgta ttgcctggcg accgggtgtg tttgcatcat     5400

cggccgcttg cacattaacc agcgagccgt cgttgcgccg gacaaggagg tcctctatga     5460

ggcttttgat gagatggagg aatgtgcctc tagggcggct ctcattgaag aggggcagcg     5520

gatagccgag atgctgaagt ccaagatcca aggcttattg cagcaagctt ccaaacaagc     5580

tcaagacata caacccactg tgcaggcttc atggcccaag gtagaacaat tctgggccaa     5640

acacatgtgg aacttcatta gcggcatcca atacctcgca ggactatcaa cactgccagg     5700

gaaccctgca gtagcttcca tgatggcgtt cagtgccgcc ctcaccagtc cgctgtcaac     5760

aagcaccact atccttctca acattttggg gggctggcta gcatcccaaa ttgcaccacc     5820

cgcgggggcc actggcttcg ttgtcagtgg cctagtggga gctgccgtag gcagtatagg     5880

cttaggtaag gtgctagtgg acatcctggc agggtatggt gcgggcattt cgggggctct     5940

cgtcgcattc aagatcatgt ctggcgagaa gccctccatg gaggatgtcg tcaacttgct     6000

gcctggaatt ctgtctccgg gtgccttggt agtgggagtc atctgcgcgg ccattctgcg     6060

ccgacacgtg ggaccggggg aaggcgccgt ccaatggatg aatagactca ttgcctttgc     6120

ttccagagga aatcacgtcg cccccaccca ctacgtgacg gagtcggatg cgtcgcagcg     6180

tgtgacccaa ctacttggct cccttaccat aaccagcctg ctcagaagac tccacaactg     6240

gattactgag gactgcccca tcccatgcgg cggctcgtgg ctccgcgatg tgtgggactg     6300

ggtttgcacc atcctaacag actttaaaaa ttggctgacc tccaaattat tcccaaagat     6360

gcccggcctc ccctttgtct cctgtcaaaa ggggtacaag ggcgtgtggg ccggcactgg     6420

catcatgacc acacggtgtc cttgcggcgc caatatctct ggcaatgtcc gcttgggctc     6480

catgagaatc acggggccta agacctgcat gaatatctgg caggggacct ttcctatcaa     6540

ttgttacacg gagggccagt gcgtgccgaa acccgcgcca aactttaagg tcgccatctg     6600

gagggtggcg gcctcagagt acgcggaggt gacgcagcac gggtcatacc actacataac     6660

aggactcacc actgataact tgaaagtccc ctgccaacta ccctctcccg agttcttttc     6720

ctgggtggac ggagtgcaga tccataggtt tgcccccaca ccgaagccgt ttttccggga     6780

tgaggtctcg ttctgcgttg ggcttaattc atttgtcgtc gggtcccagc ttccttgcga     6840

ccctgaaccc gacacagacg tattgatgtc catgctaaca gatccatctc atatcacggc     6900

ggagactgca gcgcggcgtt tagcgcgggg gtcaccccca tccgaggcaa gctcctcggc     6960

gagccagcta tcggcaccat cgctgcgagc cacctgcacc acccacggca aagcctatga     7020

tgtggacatg gtggatgcta acctgttcat ggggggcgat gtgactcgga tagagtctgg     7080

gtccaaagtg gtcgttctgg actctctcga cccaatggtc gaagaaagga gcgaccttga     7140

gccttcgata ccatcagaat acatgctccc caagaagagg ttcccaccag ctttaccggc     7200

ctgggcacgg cctgattaca acccaccgct tgtggaatcg tggaaaaggc cagattacca     7260

accggccact gttgcgggct gtgctctccc tcctcctagg aaaaccccga cgcctccccc     7320

aaggaggcgc cggacagtgg gcctaagtga ggactccata ggagatgccc ttcaacagct     7380

ggccattaag tcctttggcc agcccccccc aagcggcgat tcaggccttt ccacgggggc     7440

gggcgctgcc gattccggca gtcagacgcc tcctgatgag ttggcccttt cggagacagg     7500

ttccatctct tccatgcccc ccctcgaggg ggagcttgga gatccagacc tggagcctga     7560

gcaggtagag ccccaacccc ccccccaggg gggggtggca gctcccggct cggactcggg     7620

gtcctggtct acttgctccg aggaggacga ctccgtcgtg tgctgctcca tgtcatactc     7680

ctggaccggg gctctaataa ctccttgtag tcccgaagag gagaagttac cgattaaccc     7740

cttgagcaac tccctgttgc gatatcacaa caaggtgtac tgtaccacaa caaagagcgc     7800

ctcactaagg gctaaaaagg taacttttga taggatgcaa gtgctcgact cctactacga     7860

ctcagtctta aaggacatta agctagcggc ctccaaggtc accgcaaggc tcctcaccat     7920

ggaggaggct tgccagttaa ccccacccca ttctgcaaga tctaaatatg ggtttggggc     7980

taaggaggtc cgcagcttgt ccgggagggc cgttaaccac atcaagtccg tgtggaagga     8040

cctcctggag gactcagaaa caccaattcc cacaaccatt atggccaaaa atgaggtgtt     8100

ctgcgtggac cccaccaagg ggggcaagaa agcagctcgc cttatcgttt accctgacct     8160

cggcgtcagg gtctgcgaga agatggccct ttatgacatt acacaaaaac ttcctcaggc     8220

ggtgatgggg gcttcttatg gattccagta ttcccccgct cagcgggtag agtttctctt     8280

gaaagcatgg gcggaaaaga aggaccctat gggtttttcg tatgataccc gatgctttga     8340

ctcaaccgtc actgagagag acatcaggac tgaggagtcc atatatcggg cctgctcctt     8400

gcccgaggag gcccacactg ccatacactc gctaactgag agactttacg tgggagggcc     8460

tatgttcaac agcaagggcc aaacctgcgg gtacaggcgt tgccgcgcca gcggggtgct     8520

caccactagc atggggaaca ccatcacatg ctacgtgaaa gccttagcgg cttgtaaagc     8580

tgcagggata atcgcgccca caatgctggt atgcggcgat gacttggttg tcatctcaga     8640

aagccagggg accgaggagg acgagcggaa cctgagagcc ttcacggagg ctatgaccag     8700

gtattctgcc cctcctggtg acccccccag accggagtat gatctggagc tgataacatc     8760

ttgctcctca aatgtgtctg tggcgctggg cccacaaggc cgccgcagat actacctgac     8820

cagagaccct accactccaa tcgcccgggc tgcctgggaa acagttagac actcccctgt     8880

caattcatgg ctgggaaaca tcatccagta cgccccgacc atatgggctc gcatggtcct     8940

gatgacacac ttcttctcca ttctcatggc tcaagacacg ctggaccaga acctcaactt     9000

tgagatgtac ggagcggtgt actccgtgag tcccttggac ctcccagcta taattgaaag     9060

gttacatggg cttgacgctt tttctatgca cacatacact caccacgaac tgacacgggt     9120

ggcttcagcc ctcagaaaac ttggggcgcc acccctcaga gcgtggaaga gccgggcacg     9180

tgcagtcagg gcgtccctca tctcccgtgg ggggaaagcg gccgtttgcg gtcgatatct     9240

cttcaattgg gcggtgaaga ccaagctcaa actcactcca ttgccggaag cgcgcctcct     9300

ggatttatcc agctggttca ccgtcggcgc cggcgggggc gacatttttc acagcgtgtc     9360

gcgtgcccga ccccgcttat tgctctttgg cctactccta ctttttgtag gggtaggcct     9420

tttcctactc cccgctcggt agagcggcac acattaggta cactccatag ctaactgtcc     9480

cttttttttt tttttttttt tttttttttt tttttttttt tttttttttt ttcttttttt     9540

ctcttttcct tctttcttac cttattttac tttctttcct ggtggctcca tcttagccct     9600

agtcacggct agctgtgaaa ggtccgtgag ccgcatgact gcagagagtg ccgtaactgg     9660

tctctctgca gatcatgt                                                   9678


<210>  20
<211>  9678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  20
acccgcccct aataggggcg acactccgcc atgaatcact cccctgtgag gaactactgt       60

cttcacgcag aaagcgtcta gccatggcgt tagtatgagt gtcgtacagc ctccaggccc      120

ccccctcccg ggagagccat agtggtctgc ggaaccggtg agtacaccgg aattgccggg      180

aagactgggt cctttcttgg ataaacccac tctatgcccg gccatttggg cgtgcccccg      240

caagactgct agccgagtag cgttgggttg cgaaaggcct tgtggtactg cctgataggg      300

tgcttgcgag tgccccggga ggtctcgtag accgtgcacc atgagcacaa atcctaaacc      360

tcaaagaaaa accaaaagaa acaccaaccg tcgcccacaa gacgttaagt ttccgggcgg      420

cggccagatc gttggcggag tatacttgtt gccgcgcagg ggccccaggt tgggtgtgcg      480

cgcgacaagg aagacttcgg agcggtccca gccacgtgga aggcgccagc ccatccctaa      540

agatcggcgc tccactggca aatcctgggg aaaaccagga tacccctggc ccctatacgg      600

gaatgaggga ctcggctggg caggatggct cctgtccccc cgaggttccc gtccctcttg      660

gggccccaat gacccccggc ataggtcgcg caacgtgggt aaggtcatcg ataccctaac      720

gtgcggcttt gccgacctca tggggtacat ccctgtcgtg ggcgccccgc tcggcggcgt      780

cgccagagct ctcgcgcatg gcgtgagagt cctggaggac ggggttaatt ttgcaacagg      840

gaacttaccc ggttgctcct tttctatctt cttgctggcc ctgctgtcct gcatcaccac      900

cccggtctcc gctgccgaag tgaagaacat cagtaccggc tacatggtga ctaacgactg      960

caccaatgac agcattacct ggcagctcca ggctgctgtc ctccacgtcc ccgggtgcgt     1020

cccgtgcgag aaagtgggga atgcatctca gtgctggata ccggtctcac cgaatgtggc     1080

cgtgcagcgg cccggcgccc tcacgcaggg cttgcggacg cacatcgaca tggttgtgat     1140

gtccgccacg ctctgctctg ccctctacgt gggggacctc tgcggtgggg tgatgctcgc     1200

agcccaaatg ttcattgtct cgccgcagca ccactggttt gtccaagact gcaattgctc     1260

catctaccct ggtaccatca ctggacaccg catggcatgg gacatgatga tgaactggtc     1320

gcccacggct accatgatct tggcgtacgc gatgcgtgtc cccgaggtca ttatagacat     1380

cattagcggg gctcattggg gcgtcatgtt cggcttggcc tacttctcta tgcagggagc     1440

gtgggcgaaa gtcgttgtca tccttctgtt ggccgccggg gtggacgcgc gcacccatac     1500

tgttgggggt tctgccgcgc agaccaccgg gcgcctcacc agcttatttg acatgggccc     1560

caggcagaaa atccagctcg ttaacaccaa tggcagctgg cacatcaacc gcaccgccct     1620

gaactgcaat gactccttgc acaccggctt tatcgcgtct ctgttctaca cccacagctt     1680

caactcgtca ggatgtcccg aacgcatgtc cgcctgccgc agtatcgagg ccttccgggt     1740

gggatggggc gccttgcaat atgaggataa tgtcaccaat ccagaggata tgagacccta     1800

ttgctggcac tacccaccaa ggcagtgtgg cgtggtctcc gcgaagactg tgtgtggccc     1860

agtgtactgt ttcaccccca gcccagtggt agtgggcacg accgacaggc ttggagcgcc     1920

cacttacacg tggggggaga atgagacaga tgtcttccta ttgaacagca ctcgaccacc     1980

gctggggtca tggttcggct gcacgtggat gaactcttct ggctacacca agacttgcgg     2040

cgcaccaccc tgccgtacta gagctgactt caacgccagc acggacctgt tgtgccccac     2100

ggactgtttt aggaagcatc ctgataccac ttacctcaaa tgcggctctg ggccctggct     2160

cacgccaagg tgcctgatcg actaccccta caggctctgg cattacccct gcacagttaa     2220

ctataccatc ttcaaaataa ggatgtatgt gggaggggtt gagcacaggc tcacggctgc     2280

atgcaatttc actcgtgggg atcgttgcaa cttggaggac agagacagaa gtcaactgtc     2340

tcctttgttg cactccacca cggaatgggc cattttacct tgctcttact cggacctgcc     2400

cgccttgtcg actggtcttc tccacctcca ccaaaacatc gtggacgtac aattcatgta     2460

tggcctatca cctgccctca caaaatacat cgtccgatgg gagtgggtaa tactcttatt     2520

cctgctctta gcggacgcca gggtttgcgc ctgcttatgg atgctcatct tgttgggcca     2580

ggccgaagca gcactagaga agctggtcat cttgcacgct gcgagcgcag ctagctgcaa     2640

tggcttccta tattttgtca tcttttccgt ggctgcttgg tacatcaagg gtcgggtagt     2700

ccccttagct acctattccc tcactggcct gtggtccttt agcctactgc tcctagcatt     2760

gccccaacag gcttatgctt atgacgcatc tgtgcatggc cagataggag cggctctgct     2820

ggtaatgatc actctcttta ctctcacccc cgggtataag acccttctca gccggttttt     2880

gtggtggttg tgctatcttc tgaccctggg ggaagctatg gtccaggagt gggcaccacc     2940

tatgcaggtg cgcggtggcc gtgatggcat catatgggcc gtcgccatat tctacccagg     3000

tgtggtgttt gacataacca agtggctctt ggcggtgctt gggcctgctt acctcctaaa     3060

aggtgctttg acgcgcgtgc cgtacttcgt cagggctcac gctctactga ggatgtgcac     3120

catggcaagg catctcgcgg ggggcaggta cgtccagatg gcgctactag cccttggcag     3180

gtggactggc acttacatct atgaccacct cacccctatg tcggattggg ctgctagtgg     3240

cctgcgggac ctggcggtcg ccgttgagcc tatcatcttc agtccgatgg agaagaaagt     3300

cattgtctgg ggagcggaga cagctgcttg tggggacatt ttacacggac ttcccgtgtc     3360

cgcccgactt ggtcgggagg tcctccttgg cccagctgat ggctatacct ccaaggggtg     3420

gagtcttctc gcccccatca ctgcttacgc ccagcagaca cgtggccttt tgggcaccat     3480

agtggtgagc atgacggggc gcgacaagac agaacaggct ggggaaattc aggtcctgtc     3540

cacagtcact cagtccttcc tcggaacatc catctcgggg gttttgtgga ctgtctacca     3600

tggagctggc aacaagactc tggccggctc acggggtccg gtcacgcaga tgtactccag     3660

tgctgagggg gacttagtag ggtggcccag cccccctggg actaaatctt tggagccgtg     3720

cacgtgtgga gcggtcgacc tgtacctggt cacgcggaac gctgatgtca tcccggctcg     3780

aagacgcggg gacaaacggg gagcgctact ctccccgaga cctctttcca ccttgaaggg     3840

gtcctcagga ggcccggtgc tatgccccag gggccacgct gtcggagtct tccgggcagc     3900

tgtgtgctct cggggcgtgg ctaagtccat agatttcatc cccgttgaga cactcgacat     3960

cgtcacgcgg tcccccacct ttagtgacaa cagcacacca cctgctgtgc cccagaccta     4020

tcaggtcggg tacttgcatg ccccgactgg cagtggaaag agcaccaaag ttcctgtcgc     4080

atatgctgct caggggtata aagtgctagt gcttaatccc tcagtggctg ccaccctggg     4140

gtttggggcg tacttgtcta aggcacatgg catcaatccc aacattagga ctggagtcag     4200

gactgtgacg accggggcgc ccatcacgta ctccacatat ggcaaattcc tcgccgatgg     4260

gggctgtgcg ggcggcgcct acgacatcat catatgtgat gaatgccatg ccgtggactc     4320

taccaccatc cttggcatcg gaacagtcct tgatcaagca gagacagctg gggtcagact     4380

aactgtgctg gctacagcta cgccccctgg gtcagtgaca accccccacc ccaacataga     4440

ggaggtggcc cttgggcagg agggcgagat ccccttctat gggagggcga ttcccctgtc     4500

ttacatcaag ggaggaagac atctgatctt ctgccattca aagaaaaagt gtgacgagct     4560

cgcggcggcc cttcggggta tgggcttgaa ctcagtggca tactacagag ggttggacgt     4620

ctccgtaata ccaactcagg gagacgtagt ggtcgtcgcc accgacgccc tcatgacagg     4680

gtatactggg gactttgact ccgtgatcga ctgcaacgta gcggtcactc aagttgtaga     4740

cctcagttta gaccccacat tcaccataac cacacagatt gtccctcaag acgctgtctc     4800

acgtagccag cgccggggtc gcacgggtag gggaagactg ggcatttata ggtatgtttc     4860

cactggtgag cgagcctcag gaatgtttga cagtgtagtg ctctgtgagt gctacgacgc     4920

aggggccgca tggtatgagc tcacaccatc ggagaccacc gtcaggctca gggcgtattt     4980

caacacgccc ggtttgcctg tgtgccaaga ccatcttgag ttttgggagg cagttttcac     5040

cggcctcaca cacatagatg cccacttcct ttcccaaaca aagcaatcgg gggaaaattt     5100

cgcatactta acagcctacc aggctacagt gtgcgctagg gccaaagccc cccccccgtc     5160

ctgggacgtc atgtggaagt gtttgactcg actcaagccc acactcgtgg gccccacacc     5220

tctcctgtac cgcttgggct ctgttaccaa cgaggtcacc ctcacacatc ccgtgacgaa     5280

atacatcgcc acctgcatgc aagccgacct tgaggtcatg accagcacat gggtcttggc     5340

agggggagtc ttggcggccg tcgcctcgta ttgcctggcg accgggtgtg tttgcatcat     5400

cggccgcttg cacattaacc agcgagccgt cgttgcgccg gacaaggagg tcctctatga     5460

ggcttttgat gagatggagg aatgtgcctc tagggcggct ctcattgaag aggggcagcg     5520

gatagccgag atgctgaagt ccaagatcca aggcttattg cagcaagctt ccaaacaagc     5580

tcaagacata caacccactg tgcaggcttc atggcccaag gtagaacaat tctgggccaa     5640

acacatgtgg aacttcatta gcggcatcca atacctcgca ggactatcaa cactgccagg     5700

gaaccctgca gtagcttcca tgatggcgtt cagtgccgcc ctcaccagtc cgctgtcaac     5760

aagcaccact atccttctca acattttggg gggctggcta gcatcccaaa ttgcaccacc     5820

cgcgggggcc actggcttcg ttgtcagtgg cctagtggga gctgccgtag gcagtatagg     5880

cttaggtaag gtgctagtgg acatcctggc agggtatggt gcgggcattt cgggggctct     5940

cgtcgcattc aagatcatgt ctggcgagaa gccctccatg gaggatgtcg tcaacttgct     6000

gcctggaatt ctgtctccgg gtgccttggt agtgggagtc atctgcgcgg ccattctgcg     6060

ccgacacgtg ggaccggggg aaggcgccgt ccaatggatg aatagactca ttgcctttgc     6120

ttccagagga aatcacgtcg cccccaccca ctacgtgacg gagtcggatg cgtcgcagcg     6180

tgtgacccaa ctacttggct cccttaccat aaccagcctg ctcagaagac tccacaactg     6240

gattactgag gactgcccca tcccatgcgg cggctcgtgg ctccgcgatg tgtgggactg     6300

ggtttgcacc atcctaacag actttaaaaa ttggctgacc tccaaattat tcccaaagat     6360

gcccggcctc ccctttgtct cctgtcaaaa ggggtacaag ggcgtgtggg ccggcactgg     6420

catcatgacc acacggtgtc cttgcggcgc caatatctct ggcaatgtcc gcttgggctc     6480

catgagaatc acggggccta agacctgcat gaatatctgg caggggacct ttcctatcaa     6540

ttgttacacg gagggccagt gcgtgccgaa acccgcgcca aactttaagg tcgccatctg     6600

gagggtggcg gcctcagagt acgcggaggt gacgcagcac gggtcatacc actacataac     6660

aggactcacc actgataact tgaaagtccc ctgccaacta ccctctcccg agttcttttc     6720

ctgggtggac ggagtgcaga tccataggtt tgcccccaca ccgaagccgt ttttccggga     6780

tgaggtctcg ttctgcgttg ggcttaattc atttgtcgtc gggtcccagc ttccttgcga     6840

ccctgaaccc gacacagacg tattgatgtc catgctaaca gatccatctc atatcacggc     6900

ggagactgca gcgcggcgtt tagcgcgggg gtcaccccca tccgaggcaa gctcctcggc     6960

gagccagcta tcggcaccat cgctgcgagc cacctgcacc acccacggca aagcctatga     7020

tgtggacatg gtggatgcta acctgttcat ggggggcgat gtgactcgga tagagtctgg     7080

gtccaaagtg gtcgttctgg actctctcga cccaatggtc gaagaaagga gcgaccttga     7140

gccttcgata ccatcagaat acatgctccc caagaagagg ttcccaccag ctttaccggc     7200

ctgggcacgg cctgattaca acccaccgct tgtggaatcg tggaaaaggc cagattacca     7260

accggccact gttgcgggct gtgctctccc tcctcctagg aaaaccccga cgcctccccc     7320

aaggaggcgc cggacagtgg gcctaagtga ggactccata ggagatgccc ttcaacagct     7380

ggccattaag tcctttggcc agcccccccc aagcggcgat tcaggccttt ccacgggggc     7440

gggcgctgcc gattccggca gtcagacgcc tcctgatgag ttggcccttt cggagacagg     7500

ttccatctct tccatgcccc ccctcgaggg ggagcttgga gatccagacc tggagcctga     7560

gcaggtagag ccccaacccc ccccccaggg gggggtggca gctcccggct cggactcggg     7620

gtcctggtct acttgctccg aggaggacga ctccgtcgtg tgctgctcca tgtcatactc     7680

ctggaccggg gctctaataa ctccttgtag tcccgaagag gagaagttac cgattaaccc     7740

cttgagcaac tccctgttgc gatatcacaa caaggtgtac tgtaccacaa caaagagcgc     7800

ctcactaagg gctaaaaagg taacttttga taggatgcaa gtgctcgact cctactacga     7860

ctcagtctta aaggacatta agctagcggc ctccaaggtc accgcaaggc tcctcaccat     7920

ggaggaggct tgccagttaa ccccacccca ttctgcaaga tctaaatatg ggtttggggc     7980

taaggaggtc cgcagcttgt ccgggagggc cgttaaccac atcaagtccg tgtggaagga     8040

cctcctggag gactcagaaa caccaattcc cacaaccatt atggccaaaa atgaggtgtt     8100

ctgcgtggac cccaccaagg ggggcaagaa agcagctcgc cttatcgttt accctgacct     8160

cggcgtcagg gtctgcgaga agatggccct ttatgacatt acacaaaaac ttcctcaggc     8220

ggtgatgggg gcttcttatg gattccagta ttcccccgct cagcgggtag agtttctctt     8280

gaaagcatgg gcggaaaaga aggaccctat gggtttttcg tatgataccc gatgctttga     8340

ctcaaccgtc actgagagag acatcaggac tgaggagtcc atatatcggg cctgctcctt     8400

gcccgaggag gcccacactg ccatacactc gctaactgag agactttacg tgggagggcc     8460

tatgttcaac agcaagggcc aaacctgcgg gtacaggcgt tgccgcgcca gcggggtgct     8520

caccactagc atggggaaca ccatcacatg ctacgtgaaa gccttagcgg cttgtaaagc     8580

tgcagggata atcgcgccca caatgctggt atgcggcgat gacttggttg tcatctcaga     8640

aagccagggg accgaggagg acgagcggaa cctgagagcc ttcacggagg ctatgaccag     8700

gtattctgcc cctcctggtg acccccccag accggagtat gatctggagc tgataacatc     8760

ttgctcctca aatgtgtctg tggcgctggg cccacaaggc cgccgcagat actacctgac     8820

cagagaccct accactccaa tcgcccgggc tgcctgggaa acagttagac actcccctgt     8880

caattcatgg ctgggaaaca tcatccagta cgccccgacc atatgggctc gcatggtcct     8940

gatgacacac ttcttctcca ttctcatggc tcaagacacg ctggaccaga acctcaactt     9000

tgagatgtac ggagcggtgt actccgtgag tcccttggac ctcccagcta taattgaaag     9060

gttacatggg cttgacgctt tttctctgca cacatacact ccccacgaac tgacacgggt     9120

ggcttcagcc ctcagaaaac ttggggcgcc acccctcaga gcgtggaaga gccgggcacg     9180

tgcagtcagg gcgtccctca tctcccgtgg ggggagagcg gccgtttgcg gtcgatatct     9240

cttcaattgg gcggtgaaga ccaagctcaa actcactcca ttgccggaag cgcgcctcct     9300

ggatttatcc agctggttca ccgtcggcgc cggcgggggc gacatttttc acagcgtgtc     9360

gcgtgcccga ccccgcttat tgctctttgg cctactccta ctttttgtag gggtaggcct     9420

tttcctactc cccgctcggt agagcggcac acattaggta cactccatag ctaactgtcc     9480

cttttttttt tttttttttt tttttttttt tttttttttt tttttttttt ttcttttttt     9540

ctcttttcct tctttcttac cttattttac tttctttcct ggtggctcca tcttagccct     9600

agtcacggct agctgtgaaa ggtccgtgag ccgcatgact gcagagagtg ccgtaactgg     9660

tctctctgca gatcatgt                                                   9678


<210>  21
<211>  9678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  21
acccgcccct aataggggcg acactccgcc atgaatcact cccctgtgag gaactactgt       60

cttcacgcag aaagcgtcta gccatggcgt tagtatgagt gtcgtacagc ctccaggccc      120

ccccctcccg ggagagccat agtggtctgc ggaaccggtg agtacaccgg aattgccggg      180

aagactgggt cctttcttgg ataaacccac tctatgcccg gccatttggg cgtgcccccg      240

caagactgct agccgagtag cgttgggttg cgaaaggcct tgtggtactg cctgataggg      300

tgcttgcgag tgccccggga ggtctcgtag accgtgcacc atgagcacaa atcctaaacc      360

tcaaagaaaa accaaaagaa acaccaaccg tcgcccacaa gacgttaagt ttccgggcgg      420

cggccagatc gttggcggag tatacttgtt gccgcgcagg ggccccaggt tgggtgtgcg      480

cgcgacaagg aagacttcgg agcggtccca gccacgtgga aggcgccagc ccatccctaa      540

agatcggcgc tccactggca aatcctgggg aaaaccagga tacccctggc ccctatacgg      600

gaatgaggga ctcggctggg caggatggct cctgtccccc cgaggttccc gtccctcttg      660

gggccccaat gacccccggc ataggtcgcg caacgtgggt aaggtcatcg ataccctaac      720

gtgcggcttt gccgacctca tggggtacat ccctgtcgtg ggcgccccgc tcggcggcgt      780

cgccagagct ctcgcgcatg gcgtgagagt cctggaggac ggggttaatt ttgcaacagg      840

gaacttaccc ggttgctcct tttctatctt cttgctggcc ctgctgtcct gcatcaccac      900

cccggtctcc gctgccgaag tgaagaacat cagtaccggc tacatggtga ctaacgactg      960

caccaatgac agcattacct ggcagctcca ggctgctgtc ctccacgtcc ccgggtgcgt     1020

cccgtgcgag aaagtgggga atgcatctca gtgctggata ccggtctcac cgaatgtggc     1080

cgtgcagcgg cccggcgccc tcacgcaggg cttgcggacg cacatcgaca tggttgtgat     1140

gtccgccacg ctctgctctg ccctctacgt gggggacctc tgcggtgggg tgatgctcgc     1200

agcccaaatg ttcattgtct cgccgcagca ccactggttt gtccaagact gcaattgctc     1260

catctaccct ggtaccatca ctggacaccg catggcatgg gacatgatga tgaactggtc     1320

gcccacggct accatgatct tggcgtacgc gatgcgtgtc cccgaggtca ttatagacat     1380

cattagcggg gctcattggg gcgtcatgtt cggcttggcc tacttctcta tgcagggagc     1440

gtgggcgaaa gtcgttgtca tccttctgtt ggccgccggg gtggacgcgc gcacccatac     1500

tgttgggggt tctgccgcgc agaccaccgg gcgcctcacc agcttatttg acatgggccc     1560

caggcagaaa atccagctcg ttaacaccaa tggcagctgg cacatcaacc gcaccgccct     1620

gaactgcaat gactccttgc acaccggctt tatcgcgtct ctgttctaca cccacagctt     1680

caactcgtca ggatgtcccg aacgcatgtc cgcctgccgc agtatcgagg ccttccgggt     1740

gggatggggc gccttgcaat atgaggataa tgtcaccaat ccagaggata tgagacccta     1800

ttgctggcac tacccaccaa ggcagtgtgg cgtggtctcc gcgaagactg tgtgtggccc     1860

agtgtactgt ttcaccccca gcccagtggt agtgggcacg accgacaggc ttggagcgcc     1920

cacttacacg tggggggaga atgagacaga tgtcttccta ttgaacagca ctcgaccacc     1980

gctggggtca tggttcggct gcacgtggat gaactcttct ggctacacca agacttgcgg     2040

cgcaccaccc tgccgtacta gagctgactt caacgccagc acggacctgt tgtgccccac     2100

ggactgtttt aggaagcatc ctgataccac ttacctcaaa tgcggctctg ggccctggct     2160

cacgccaagg tgcctgatcg actaccccta caggctctgg cattacccct gcacagttaa     2220

ctataccatc ttcaaaataa ggatgtatgt gggaggggtt gagcacaggc tcacggctgc     2280

atgcaatttc actcgtgggg atcgttgcaa cttggaggac agagacagaa gtcaactgtc     2340

tcctttgttg cactccacca cggaatgggc cattttacct tgctcttact cggacctgcc     2400

cgccttgtcg actggtcttc tccacctcca ccaaaacatc gtggacgtac aattcatgta     2460

tggcctatca cctgccctca caaaatacat cgtccgatgg gagtgggtaa tactcttatt     2520

cctgctctta gcggacgcca gggtttgcgc ctgcttatgg atgctcatct tgttgggcca     2580

ggccgaagca gcactagaga agctggtcat cttgcacgct gcgagcgcag ctagctgcaa     2640

tggcttccta tattttgtca tctttttcgt ggctgcttgg tacatcaagg gtcgggtagt     2700

ccccttagct acctattccc tcactggcct gtggtccttt agcctactgc tcctagcatt     2760

gccccaacag gcttatgctt atgacgcatc tgtgcatggc cagataggag cggctctgct     2820

ggtaatgatc actctcttta ctctcacccc cgggtataag acccttctca gccggttttt     2880

gtggtggttg tgctatcttc tgaccctggg ggaagctatg gtccaggagt gggcaccacc     2940

tatgcaggtg cgcggtggcc gtgatggcat catatgggcc gtcgccatat tctacccagg     3000

tgtggtgttt gacataacca agtggctctt ggcggtgctt gggcctgctt acctcctaaa     3060

aggtgctttg acgcgcgtgc cgtacttcgt cagggctcac gctctactga ggatgtgcac     3120

catggcaagg catctcgcgg ggggcaggta cgtccagatg gcgctactag cccttggcag     3180

gtggactggc acttacatct atgaccacct cacccctatg tcggattggg ctgctagtgg     3240

cctgcgggac ctggcggtcg ccgttgagcc tatcatcttc agtccgatgg agaagaaagt     3300

cattgtctgg ggagcggaga cagctgcttg tggggacatt ttacacggac ttcccgtgtc     3360

cgcccgactt ggtcgggagg tcctccttgg cccagctgat ggctatacct ccaaggggtg     3420

gagtcttctc gcccccatca ctgcttacgc ccagcagaca cgtggccttt tgggcaccat     3480

agtggtgagc atgacggggc gcgacaagac agaacaggct ggggaaattc aggtcctgtc     3540

cacagtcact cagtccttcc tcggaacatc catctcgggg gttttgtgga ctgtctacca     3600

tggagctggc aacaagactc tggccggctc acggggtccg gtcacgcaga tgtactccag     3660

tgctgagggg gacttagtag ggtggcccag cccccctggg actaaatctt tggagccgtg     3720

cacgtgtgga gcggtcgacc tgtacctggt cacgcggaac gctgatgtca tcccggctcg     3780

aagacgcggg gacaaacggg gagcgctact ctccccgaga cctctttcca ccttgaaggg     3840

gtcctcagga ggcccggtgc tatgccccag gggccacgct gtcggagtct tccgggcagc     3900

tgtgtgctct cggggcgtgg ctaagtccat agatttcatc cccgttgaga cactcgacat     3960

cgtcacgcgg tcccccacct ttagtgacaa cagcacacca cctgctgtgc cccagaccta     4020

tcaggtcggg tacttgcatg ccccgactgg cagtggaaag agcaccaaag ttcctgtcgc     4080

atatgctgct caggggtata aagtgctagt gcttaatccc tcagtggctg ccaccctggg     4140

gtttggggcg tacttgtcta aggcacatgg catcaatccc aacattagga ctggagtcag     4200

gactgtgacg accggggcgc ccatcacgta ctccacatat ggcaaattcc tcgccgatgg     4260

gggctgtgcg ggcggcgcct acgacatcat catatgtgat gaatgccatg ccgtggactc     4320

taccaccatc cttggcatcg gaacagtcct tgatcaagca gagacagctg gggtcagact     4380

aactgtgctg gctacagcta cgccccctgg gtcagtgaca accccccacc ccaacataga     4440

ggaggtggcc cttgggcagg agggcgagat ccccttctat gggagggcga ttcccctgtc     4500

ttacatcaag ggaggaagac atctgatctt ctgccattca aagaaaaagt gtgacgagct     4560

cgcggcggcc cttcggggta tgggcttgaa ctcagtggca tactacagag ggttggacgt     4620

ctccgtaata ccaactcagg gagacgtagt ggtcgtcgcc accgacgccc tcatgacagg     4680

gtatactggg gactttgact ccgtgatcga ctgcaacgta gcggtcactc aagttgtaga     4740

cctcagttta gaccccacat tcaccataac cacacagatt gtccctcaag acgctgtctc     4800

acgtagccag cgccggggtc gcacgggtag gggaagactg ggcatttata ggtatgtttc     4860

cactggtgag cgagcctcag gaatgtttga cagtgtagtg ctctgtgagt gctacgacgc     4920

aggggccgca tggtatgagc tcacaccatc ggagaccacc gtcaggctca gggcgtattt     4980

caacacgccc ggtttgcctg tgtgccaaga ccatcttgag ttttgggagg cagttttcac     5040

cggcctcaca cacatagatg cccacttcct ttcccaaaca aagcaatcgg gggaaaattt     5100

cgcatactta acagcctacc aggctacagt gtgcgctagg gccaaagccc cccccccgtc     5160

ctgggacgtc atgtggaagt gtttgactcg actcaagccc acactcgtgg gccccacacc     5220

tctcctgtac cgcttgggct ctgttaccaa cgaggtcacc ctcacacatc ccgtgacgaa     5280

atacatcgcc acctgcatgc aagccgacct tgaggtcatg accagcacat gggtcttggc     5340

agggggagtc ttggcggccg tcgcctcgta ttgcctggcg accgggtgtg tttgcatcat     5400

cggccgcttg cacattaacc agcgagccgt cgttgcgccg gacaaggagg tcctctatga     5460

ggcttttgat gagatggagg aatgtgcctc tagggcggct ctcattgaag aggggcagcg     5520

gatagccgag atgctgaagt ccaagatcca aggcttattg cagcaagctt ccaaacaagc     5580

tcaagacata caacccactg tgcaggcttc atggcccaag gtagaacaat tctgggccaa     5640

acacatgtgg aacttcatta gcggcatcca atacctcgca ggactatcaa cactgccagg     5700

gaaccctgca gtagcttcca tgatggcgtt cagtgccgcc ctcaccagtc cgctgtcaac     5760

aagcaccact atccttctca acattttggg gggctggcta gcatcccaaa ttgcaccacc     5820

cgcgggggcc actggcttcg ttgtcagtgg cctagtggga gctgccgtag gcagtatagg     5880

cttaggtaag gtgctagtgg acatcctggc agggtatggt gcgggcattt cgggggctct     5940

cgtcgcattc aagatcatgt ctggcgagaa gccctccatg gaggatgtcg tcaacttgct     6000

gcctggaatt ctgtctccgg gtgccttggt agtgggagtc atctgcgcgg ccattctgcg     6060

ccgacacgtg ggaccggggg aaggcgccgt ccaatggatg aatagactca ttgcctttgc     6120

ttccagagga aatcacgtcg cccccaccca ctacgtgacg gagtcggatg cgtcgcagcg     6180

tgtgacccaa ctacttggct cccttaccat aaccagcctg ctcagaagac tccacaactg     6240

gattactgag gactgcccca tcccatgcgg cggctcgtgg ctccgcgatg tgtgggactg     6300

ggtttgcacc atcctaacag actttaaaaa ttggctgacc tccaaattat tcccaaagat     6360

gcccggcctc ccctttgtct cctgtcaaaa ggggtacaag ggcgtgtggg ccggcactgg     6420

catcatgacc acacggtgtc cttgcggcgc caatatctct ggcaatgtcc gcttgggctc     6480

catgagaatc acggggccta agacctgcat gaatatctgg caggggacct ttcctatcaa     6540

ttgttacacg gagggccagt gcgtgccgaa acccgcgcca aactttaagg tcgccatctg     6600

gagggtggcg gcctcagagt acgcggaggt gacgcagcac gggtcatacc actacataac     6660

aggactcacc actgataact tgaaagtccc ctgccaacta ccctctcccg agttcttttc     6720

ctgggtggac ggagtgcaga tccataggtt tgcccccaca ccgaagccgt ttttccggga     6780

tgaggtctcg ttctgcgttg ggcttaattc atttgtcgtc gggtcccagc ttccttgcga     6840

ccctgaaccc gacacagacg tattgatgtc catgctaaca gatccatctc atatcacggc     6900

ggagactgca gcgcggcgtt tagcgcgggg gtcaccccca tccgaggcaa gctcctcggc     6960

gagccagcta tcggcaccat cgctgcgagc cacctgcacc acccacggca aagcctatga     7020

tgtggacatg gtggatgcta acctgttcat ggggggcgat gtgactcgga tagagtctgg     7080

gtccaaagtg gtcgttctgg actctctcga cccaatggtc gaagaaagga gcgaccttga     7140

gccttcgata ccatcagaat acatgctccc caagaagagg ttcccaccag ctttaccggc     7200

ctgggcacgg cctgattaca acccaccgct tgtggaatcg tggaaaaggc cagattacca     7260

accggccact gttgcgggct gtgctctccc tcctcctagg aaaaccccga cgcctccccc     7320

aaggaggcgc cggacagtgg gcctaagtga ggactccata ggagatgccc ttcaacagct     7380

ggccattaag tcctttggcc agcccccccc aagcggcgat tcaggccttt ccacgggggc     7440

gggcgctgcc gattccggca gtcagacgcc tcctgatgag ttggcccttt cggagacagg     7500

ttccatctct tccatgcccc ccctcgaggg ggagcttgga gatccagacc tggagcctga     7560

gcaggtagag ccccaacccc ccccccaggg gggggtggca gctcccggct cggactcggg     7620

gtcctggtct acttgctccg aggaggacga ctccgtcgtg tgctgctcca tgtcatactc     7680

ctggaccggg gctctaataa ctccttgtag tcccgaagag gagaagttac cgattaaccc     7740

cttgagcaac tccctgttgc gatatcacaa caaggtgtac tgtaccacaa caaagagcgc     7800

ctcactaagg gctaaaaagg taacttttga taggatgcaa gtgctcgact cctactacga     7860

ctcagtctta aaggacatta agctagcggc ctccaaggtc accgcaaggc tcctcaccat     7920

ggaggaggct tgccagttaa ccccacccca ttctgcaaga tctaaatatg ggtttggggc     7980

taaggaggtc cgcagcttgt ccgggagggc cgttaaccac atcaagtccg tgtggaagga     8040

cctcctggag gactcagaaa caccaattcc cacaaccatt atggccaaaa atgaggtgtt     8100

ctgcgtggac cccaccaagg ggggcaagaa agcagctcgc cttatcgttt accctgacct     8160

cggcgtcagg gtctgcgaga agatggccct ttatgacatt acacaaaaac ttcctcaggc     8220

ggtgatgggg gcttcttatg gattccagta ttcccccgct cagcgggtag agtttctctt     8280

gaaagcatgg gcggaaaaga aggaccctat gggtttttcg tatgataccc gatgctttga     8340

ctcaaccgtc actgagagag acatcaggac tgaggagtcc atatatcggg cctgctcctt     8400

gcccgaggag gcccacactg ccatacactc gctaactgag agactttacg tgggagggcc     8460

tatgttcaac agcaagggcc aaacctgcgg gtacaggcgt tgccgcgcca gcggggtgct     8520

caccactagc atggggaaca ccatcacatg ctacgtgaaa gccttagcgg cttgtaaagc     8580

tgcagggata atcgcgccca caatgctggt atgcggcgat gacttggttg tcatctcaga     8640

aagccagggg accgaggagg acgagcggaa cctgagagcc ttcacggagg ctatgaccag     8700

gtattctgcc cctcctggtg acccccccag accggagtat gatctggagc tgataacatc     8760

ttgctcctca aatgtgtctg tggcgctggg cccacaaggc cgccgcagat actacctgac     8820

cagagaccct accactccaa tcgcccgggc tgcctgggaa acagttagac actcccctgt     8880

caattcatgg ctgggaaaca tcatccagta cgccccgacc atatgggctc gcatggtcct     8940

gatgacacac ttcttctcca ttctcatggc tcaagacacg ctggaccaga acctcaactt     9000

tgagatgtac ggagcggtgt actccgtgag tcccttggac ctcccagcta taattgaaag     9060

gttacatggg cttgacgctt tttctctgca cacatacact ccccacgaac tgacacgggt     9120

ggcttcagcc ctcagaaaac ttggggcgcc acccctcaga gcgtggaaga gccgggcacg     9180

tgcagtcagg gcgtccctca tctcccgtgg ggggagagcg gccgtttgcg gtcgatatct     9240

cttcaattgg gcggtgaaga ccaagctcaa actcactcca ttgccggaag cgcgcctcct     9300

ggatttatcc agctggttca ccgtcggcgc cggcgggggc gacatttttc acagcgtgtc     9360

gcgtgcccga ccccgcttat tgctctttgg cctactccta ctttttgtag gggtaggcct     9420

tttcctactc cccgctcggt agagcggcac acattaggta cactccatag ctaactgtcc     9480

cttttttttt tttttttttt tttttttttt tttttttttt tttttttttt ttcttttttt     9540

ctcttttcct tctttcttac cttattttac tttctttcct ggtggctcca tcttagccct     9600

agtcacggct agctgtgaaa ggtccgtgag ccgcatgact gcagagagtg ccgtaactgg     9660

tctctctgca gatcatgt                                                   9678


<210>  22
<211>  9678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  22
acccgcccct aataggggcg acactccgcc atgaatcact cccctgtgag gaactactgt       60

cttcacgcag aaagcgtcta gccatggcgt tagtatgagt gtcgtacagc ctccaggccc      120

ccccctcccg ggagagccat agtggtctgc ggaaccggtg agtacaccgg aattgccggg      180

aagactgggt cctttcttgg ataaacccac tctatgcccg gccatttggg cgtgcccccg      240

caagactgct agccgagtag cgttgggttg cgaaaggcct tgtggtactg cctgataggg      300

tgcttgcgag tgccccggga ggtctcgtag accgtgcacc atgagcacaa atcctaaacc      360

tcaaagaaaa accaaaagaa acaccaaccg tcgcccacaa gacgttaagt ttccgggcgg      420

cggccagatc gttggcggag tatacttgtt gccgcgcagg ggccccaggt tgggtgtgcg      480

cgcgacaagg aagacttcgg agcggtccca gccacgtgga aggcgccagc ccatccctaa      540

agatcggcgc tccactggca aatcctgggg aaaaccagga tacccctggc ccctatacgg      600

gaatgaggga ctcggctggg caggatggct cctgtccccc cgaggttccc gtccctcttg      660

gggccccaat gacccccggc ataggtcgcg caacgtgggt aaggtcatcg ataccctaac      720

gtgcggcttt gccgacctca tggggtacat ccctgtcgtg ggcgccccgc tcggcggcgt      780

cgccagagct ctcgcgcatg gcgtgagagt cctggaggac ggggttaatt ttgcaacagg      840

gaacttaccc ggttgctcct tttctatctt cttgctggcc ctgctgtcct gcatcaccac      900

cccggtctcc gctgccgaag tgaagaacat cagtaccggc tacatggtga ctaacgactg      960

caccaatgac agcattacct ggcagctcca ggctgctgtc ctccacgtcc ccgggtgcgt     1020

cccgtgcgag aaagtgggga atgcatctca gtgctggata ccggtctcac cgaatgtggc     1080

cgtgcagcgg cccggcgccc tcacgcaggg cttgcggacg cacatcgaca tggttgtgat     1140

gtccgccacg ctctgctctg ccctctacgt gggggacctc tgcggtgggg tgatgctcgc     1200

agcccaaatg ttcattgtct cgccgcagca ccactggttt gtccaagact gcaattgctc     1260

catctaccct ggtaccatca ctggacaccg catggcatgg gacatgatga tgaactggtc     1320

gcccacggct accatgatct tggcgtacgc gatgcgtgtc cccgaggtca ttatagacat     1380

cattagcggg gctcattggg gcgtcatgtt cggcttggcc tacttctcta tgcagggagc     1440

gtgggcgaaa gtcgttgtca tccttctgtt ggccgccggg gtggacgcgc gcacccatac     1500

tgttgggggt tctgccgcgc agaccaccgg gcgcctcacc agcttatttg acatgggccc     1560

caggcagaaa atccagctcg ttaacaccaa tggcagctgg cacatcaacc gcaccgccct     1620

gaactgcaat gactccttgc acaccggctt tatcgcgtct ctgttctaca cccacagctt     1680

caactcgtca ggatgtcccg aacgcatgtc cgcctgccgc agtatcgagg ccttccgggt     1740

gggatggggc gccttgcaat atgaggataa tgtcaccaat ccagaggata tgagacccta     1800

ttgctggcac tacccaccaa ggcagtgtgg cgtggtctcc gcgaagactg tgtgtggccc     1860

agtgtactgt ttcaccccca gcccagtggt agtgggcacg accgacaggc ttggagcgcc     1920

cacttacacg tggggggaga atgagacaga tgtcttccta ttgaacagca ctcgaccacc     1980

gctggggtca tggttcggct gcacgtggat gaactcttct ggctacacca agacttgcgg     2040

cgcaccaccc tgccgtacta gagctgactt caacgccagc acggacctgt tgtgccccac     2100

ggactgtttt aggaagcatc ctgataccac ttacctcaaa tgcggctctg ggccctggct     2160

cacgccaagg tgcctgatcg actaccccta caggctctgg cattacccct gcacagttaa     2220

ctataccatc ttcaaaataa ggatgtatgt gggaggggtt gagcacaggc tcacggctgc     2280

atgcaatttc actcgtgggg atcgttgcaa cttggaggac agagacagaa gtcaactgtc     2340

tcctttgttg cactccacca cggaatgggc cattttacct tgctcttact cggacctgcc     2400

cgccttgtcg actggtcttc tccacctcca ccaaaacatc gtggacgtac aattcatgta     2460

tggcctatca cctgccctca caaaatacat cgtccgatgg gagtgggtaa tactcttatt     2520

cctgctctta gcggacgcca gggtttgcgc ctgcttatgg atgctcatct tgttgggcca     2580

ggccgaagca gcactagaga agctggtcat cttgcacgct gcgagcgcag ctagctgcaa     2640

tggcttccta tattttgtca tctttttcgt ggctgcttgg tacatcaagg gtcgggtagt     2700

ccccttagct acctattccc tcactggcct gtggtccttt agcctactgc tcctagcatt     2760

gccccaacag gcttatgctt atgacgcatc tgtgcatggc cagataggag cggctctgct     2820

ggtaatgatc actctcttta ctctcacccc cgggtataag acccttctca gccggttttt     2880

gtggtggttg tgctatcttc tgaccctggg ggaagctatg gtccaggagt gggcaccacc     2940

tatgcaggtg cgcggtggcc gtgatggcat catatgggcc gtcgccatat tctacccagg     3000

tgtggtgttt gacataacca agtggctctt ggcggtgctt gggcctgctt acctcctaaa     3060

aggtgctttg acgcgcgtgc cgtacttcgt cagggctcac gctctactga ggatgtgcac     3120

catggcaagg catctcgcgg ggggcaggta cgtccagatg gcgctactag cccttggcag     3180

gtggactggc acttacatct atgaccacct cacccctatg tcggattggg ctgctagtgg     3240

cctgcgggac ctggcggtcg ccgttgagcc tatcatcttc agtccgatgg agaagaaagt     3300

cattgtctgg ggagcggaga cagctgcttg tggggacatt ttacacggac ttcccgtgtc     3360

cgcccgactt ggtcgggagg tcctccttgg cccagctgat ggctatacct ccaaggggtg     3420

gagtcttctc gcccccatca ctgcttacgc ccagcagaca cgtggccttt tgggcaccat     3480

agtggtgagc atgacggggc gcgacaagac agaacaggct ggggaaattc aggtcctgtc     3540

cacagtcact cagtccttcc tcggaacatc catctcgggg gttttgtgga ctgtctacca     3600

tggagctggc aacaagactc tggccggctc acggggtccg gtcacgcaga tgtactccag     3660

tgctgagggg gacttagtag ggtggcccag cccccctggg actaaatctt tggagccgtg     3720

cacgtgtgga gcggtcgacc tgtacctggt cacgcggaac gctgatgtca tcccggctcg     3780

aagacgcggg gacaaacggg gagcgctact ctccccgaga cctctttcca ccttgaaggg     3840

gtcctcagga ggcccggtgc tatgccccag gggccacgct gtcggagtct tccgggcagc     3900

tgtgtgctct cggggcgtgg ctaagtccat agatttcatc cccgttgaga cactcgacat     3960

cgtcacgcgg tcccccacct ttagtgacaa cagcacacca cctgctgtgc cccagaccta     4020

tcaggtcggg tacttgcatg ccccgactgg cagtggaaag agcaccaaag ttcctgtcgc     4080

atatgctgct caggggtata aagtgctagt gcttaatccc tcagtggctg ccaccctggg     4140

gtttggggcg tacttgtcta aggcacatgg catcaatccc aacattagga ctggagtcag     4200

gactgtgacg accggggcgc ccatcacgta ctccacatat ggcaaattcc tcgccgatgg     4260

gggctgtgcg ggcggcgcct acgacatcat catatgtgat gaatgccatg ccgtggactc     4320

taccaccatc cttggcatcg gaacagtcct tgatcaagca gagacagctg gggtcagact     4380

aactgtgctg gctacagcta cgccccctgg gtcagtgaca accccccacc ccaacataga     4440

ggaggtggcc cttgggcagg agggcgagat ccccttctat gggagggcga ttcccctgtc     4500

ttacatcaag ggaggaagac atctgatctt ctgccattca aagaaaaagt gtgacgagct     4560

cgcggcggcc cttcggggta tgggcttgaa ctcagtggca tactacagag ggttggacgt     4620

ctccgtaata ccaactcagg gagacgtagt ggtcgtcgcc accgacgccc tcatgacagg     4680

gtatactggg gactttgact ccgtgatcga ctgcaacgta gcggtcactc aagttgtaga     4740

cttcagttta gaccccacat tcaccataac cacacagatt gtccctcaag acgctgtctc     4800

acgtagccag cgccggggtc gcacgggtag gggaagactg ggcatttata ggtatgtttc     4860

cactggtgag cgagcctcag gaatgtttga cagtgtagtg ctctgtgagt gctacgacgc     4920

aggggccgca tggtatgagc tcacaccatc ggagaccacc gtcaggctca gggcgtattt     4980

caacacgccc ggtttgcctg tgtgccaaga ccatcttgag ttttgggagg cagttttcac     5040

cggcctcaca cacatagatg cccacttcct ttcccaaaca aagcaatcgg gggaaaattt     5100

cgcatactta acagcctacc aggctacagt gtgcgctagg gccaaagccc cccccccgtc     5160

ctgggacgtc atgtggaagt gtttgactcg actcaagccc acactcgtgg gccccacacc     5220

tctcctgtac cgcttgggct ctgttaccaa cgaggtcacc ctcacacatc ccgtgacgaa     5280

atacatcgcc acctgcatgc aagccgacct tgaggtcatg accagcacat gggtcttggc     5340

agggggagtc ttggcggccg tcgccgcgta ttgcctggcg accgggtgtg tttgcatcat     5400

cggccgcttg cacattaacc agcgagccgt cgttgcgccg gacaaggagg tcctctatga     5460

ggcttttgat gagatggagg aatgtgcctc tagggcggct ctcattgaag aggggcagcg     5520

gatagccgag atgctgaagt ccaagatcca aggcttattg cagcaagctt ccaaacaagc     5580

tcaagacata caacccactg tgcaggcttc atggcccaag gtagaacaat tctgggccaa     5640

acacatgtgg aacttcatta gcggcatcca atacctcgca ggactatcaa cactgccagg     5700

gaaccctgca gtagcttcca tgatggcgtt cagtgccgcc ctcaccagtc cgctgtcaac     5760

aagcaccact atccttctca acattttggg gggctggcta gcatcccaaa ttgcaccacc     5820

cgcgggggcc actggcttcg ttgtcagtgg cctagtggga gctgccgtag gcagtatagg     5880

cttaggtaag gtgctagtgg acatcctggc agggtatggt gcgggcattt cgggggctct     5940

cgtcgcattc aagatcatgt ctggcgagaa gccctccatg gaggatgtcg tcaacttgct     6000

gcctggaatt ctgtctccgg gtgccttggt agtgggagtc atctgcgcgg ccattctgcg     6060

ccgacacgtg ggaccggggg aaggcgccgt ccaatggatg aatagactca ttgcctttgc     6120

ttccagagga aatcacgtcg cccccaccca ctacgtgacg gagtcggatg cgtcgcagcg     6180

tgtgacccaa ctacttggct cccttaccat aaccagcctg ctcagaagac tccacaactg     6240

gattactgag gactgcccca tcccatgcgg cggctcgtgg ctccgcgatg tgtgggactg     6300

ggtttgcacc atcctaacag actttaaaaa ttggctgacc tccaaattat tcccaaagat     6360

gcccggcctc ccctttgtct cctgtcaaaa ggggtacaag ggcgtgtggg ccggcactgg     6420

catcatgacc acacggtgtc cttgcggcgc caatatctct ggcaatgtcc gcttgggctc     6480

catgagaatc acggggccta agacctgcat gaatatctgg caggggacct ttcctatcaa     6540

ttgttacacg gagggccagt gcgtgccgaa acccgcgcca aactttaagg tcgccatctg     6600

gagggtggcg gcctcagagt acgcggaggt gacgcagcac gggtcatacc actacataac     6660

aggactcacc actgataact tgaaagtccc ctgccaacta ccctctcccg agttcttttc     6720

ctgggtggac ggagtgcaga tccataggtt tgcccccaca ccgaagccgt ttttccggga     6780

tgaggtctcg ttctgcgttg ggcttaattc atttgtcgtc gggtcccagc ttccttgcga     6840

ccctgaaccc gacacagacg tattgatgtc catgctaaca gatccatctc atatcacggc     6900

ggagactgca gcgcggcgtt tagcgcgggg gtcaccccca tccgaggcaa gctcctcggc     6960

gagccagcta tcggcaccat cgctgcgagc cacctgcacc acccacggca aagcctatga     7020

tgtggacatg gtggatgcta acctgttcat ggggggcgat gtgactcgga tagagtctgg     7080

gtccaaagtg gtcgttctgg actctctcga cccaatggtc gaagaaagga gcgaccttga     7140

gccttcgata ccatcagaat acatgctccc caagaagagg ttcccaccag ctttaccggc     7200

ctgggcacgg cctgattaca acccaccgct tgtggaatcg tggaaaaggc cagattacca     7260

accggccact gttgcgggct gtgctctccc tcctcctagg aaaaccccga cgcctccccc     7320

aaggaggcgc cggacagtgg gcctaagtga ggactccata ggagatgccc ttcaacagct     7380

ggccattaag tcctttggcc agcccccccc aagcggcgat tcaggccttt ccacgggggc     7440

gggcgctgcc gattccggca gtcagacgcc tcctgatgag ttggcccttt cggagacagg     7500

ttccatctct tccatgcccc ccctcgaggg ggagcttgga gatccagacc tggagcctga     7560

gcaggtagag ccccaacccc ccccccaggg gggggtggca gctcccggct cggactcggg     7620

gtcctggtct acttgctccg aggaggacga ctccgtcgtg tgctgctcca tgtcatactc     7680

ctggaccggg gctctaataa ctccttgtag tcccgaagag gagaagttac cgattaaccc     7740

cttgagcaac tccctgttgc gatatcacaa caaggtgtac tgtaccacaa caaagagcgc     7800

ctcactaagg gctaaaaagg taacttttga taggatgcaa gtgctcgact cctactacga     7860

ctcagtctta aaggacatta agctagcggc ctccaaggtc accgcaaggc tcctcaccat     7920

ggaggaggct tgccagttaa ccccacccca ttctgcaaga tctaaatatg ggtttggggc     7980

taaggaggtc cgcagcttgt ccgggagggc cgttaaccac atcaagtccg tgtggaagga     8040

cctcctggag gactcagaaa caccaattcc cacaaccatt atggccaaaa atgaggtgtt     8100

ctgcgtggac cccaccaagg ggggcaagaa agcagctcgc cttatcgttt accctgacct     8160

cggcgtcagg gtctgcgaga agatggccct ttatgacatt acacaaaaac ttcctcaggc     8220

ggtgatgggg gcttcttatg gattccagta ttcccccgct cagcgggtag agtttctctt     8280

gaaagcatgg gcggaaaaga aggaccctat gggtttttcg tatgataccc gatgctttga     8340

ctcaaccgtc actgagagag acatcaggac tgaggagtcc atatatcggg cctgctcctt     8400

gcccgaggag gcccacactg ccatacactc gctaactgag agactttacg tgggagggcc     8460

tatgttcaac agcaagggcc aaacctgcgg gtacaggcgt tgccgcgcca gcggggtgct     8520

caccactagc atggggaaca ccatcacatg ctacgtgaaa gccttagcgg cttgtaaagc     8580

tgcagggata atcgcgccca caatgctggt atgcggcgat gacttggttg tcatctcaga     8640

aagccagggg accgaggagg acgagcggaa cctgagagcc ttcacggagg ctatgaccag     8700

gtattctgcc cctcctggtg acccccccag accggagtat gatctggagc tgataacatc     8760

ttgctcctca aatgtgtctg tggcgctggg cccacaaggc cgccgcagat actacctgac     8820

cagagaccct accactccaa tcgcccgggc tgcctgggaa acagttagac actcccctgt     8880

caattcatgg ctgggaaaca tcatccagta cgccccgacc atatgggctc gcatggtcct     8940

gatgacacac ttcttctcca ttctcatggc tcaagacacg ctggaccaga acctcaactt     9000

tgagatgtac ggagcggtgt actccgtgag tcccttggac ctcccagcta taattgaaag     9060

gttacatggg cttgacgctt tttctctgca cacatacact ccccacgaac tgacacgggt     9120

ggcttcagcc ctcagaaaac ttggggcgcc acccctcaga gcgtggaaga gccgggcacg     9180

tgcagtcagg gcgtccctca tctcccgtgg ggggagagcg gccgtttgcg gtcgatatct     9240

cttcaattgg gcggtgaaga ccaagctcaa actcactcca ttgccggaag cgcgcctcct     9300

ggatttatcc agctggttca ccgtcggcgc cggcgggggc gacatttttc acagcgtgtc     9360

gcgtgcccga ccccgcttat tgctctttgg cctactccta ctttttgtag gggtaggcct     9420

tttcctactc cccgctcggt agagcggcac acattaggta cactccatag ctaactgtcc     9480

cttttttttt tttttttttt tttttttttt tttttttttt tttttttttt ttcttttttt     9540

ctcttttcct tctttcttac cttattttac tttctttcct ggtggctcca tcttagccct     9600

agtcacggct agctgtgaaa ggtccgtgag ccgcatgact gcagagagtg ccgtaactgg     9660

tctctctgca gatcatgt                                                   9678


<210>  23
<211>  9711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  23
acccgcccct aataggggcg acactccgcc atgaatcact cccctgtgag gaactactgt       60

cttcacgcag aaagcgtcta gccatggcgt tagtatgagt gtcgtacagc ctccaggccc      120

ccccctcccg ggagagccat agtggtctgc ggaaccggtg agtacaccgg aattgccggg      180

aagactgggt cctttcttgg ataaacccac tctatgcccg gccatttggg cgtgcccccg      240

caagactgct agccgagtag cgttgggttg cgaaaggcct tgtggtactg cctgataggg      300

tgcttgcgag tgccccggga ggtctcgtag accgtgcacc atgagcacaa atcctaaacc      360

tcaaagaaaa accaaaagaa acaccaaccg tcgcccacaa gacgttaagt ttccgggcgg      420

cggccagatc gttggcggag tatacttgtt gccgcgcagg ggccccaggt tgggtgtgcg      480

cgcgacaagg aagacttcgg agcggtccca gccacgtgga aggcgccagc ccatccctaa      540

agatcggcgc tccactggca aatcctgggg aaaaccagga tacccctggc ccctatacgg      600

gaatgaggga ctcggctggg caggatggct cctgtccccc cgaggttccc gtccctcttg      660

gggccccaat gacccccggc ataggtcgcg caacgtgggt aaggtcatcg ataccctaac      720

gtgcggcttt gccgacctca tggggtacat ccctgtcgtg ggcgccccgc tcggcggcgt      780

cgccagagct ctcgcgcatg gcgtgagagt cctggaggac ggggttaatt ttgcaacagg      840

gaacttaccc ggttgctcct tttctatctt cttgctggcc ctgctgtcct gcatcaccac      900

cccggtctcc gctgccgaag tgaagaacat cagtaccggc tacatggtga ctaacgactg      960

caccaatgac agcattacct ggcagctcca ggctgctgtc ctccacgtcc ccgggtgcgt     1020

cccgtgcgag aaagtgggga atgcatctca gtgctggata ccggtctcac cgaatgtggc     1080

cgtgcagcgg cccggcgccc tcacgcaggg cttgcggacg cacatcgaca tggttgtgat     1140

gtccgccacg ctctgctctg ccctctacgt gggggacctc tgcggtgggg tgatgctcgc     1200

agcccaaatg ttcattgtct cgccgcagca ccactggttt gtccaagact gcaattgctc     1260

catctaccct ggtaccatca ctggacaccg catggcatgg gacatgatga tgaactggtc     1320

gcccacggct accatgatct tggcgtacgc gatgcgtgtc cccgaggtca ttatagacat     1380

cattagcggg gctcattggg gcgtcatgtt cggcttggcc tacttctcta tgcagggagc     1440

gtgggcgaaa gtcgttgtca tccttctgtt ggccgccggg gtggacgcgc gcacccatac     1500

tgttgggggt tctgccgcgc agaccaccgg gcgcctcacc agcttatttg acatgggccc     1560

caggcagaaa atccagctcg ttaacaccaa tggcagctgg cacatcaacc gcaccgccct     1620

gaactgcaat gactccttgc acaccggctt tatcgcgtct ctgttctaca cccacagctt     1680

caactcgtca ggatgtcccg aacgcatgtc cgcctgccgc agtatcgagg ccttccgggt     1740

gggatggggc gccttgcaat atgaggataa tgtcaccaat ccagaggata tgagacccta     1800

ttgctggcac tacccaccaa ggcagtgtgg cgtggtctcc gcgaagactg tgtgtggccc     1860

agtgtactgt ttcaccccca gcccagtggt agtgggcacg accgacaggc ttggagcgcc     1920

cacttacacg tggggggaga atgagacaga tgtcttccta ttgaacagca ctcgaccacc     1980

gctggggtca tggttcggct gcacgtggat gaactcttct ggctacacca agacttgcgg     2040

cgcaccaccc tgccgtacta gagctgactt caacgccagc acggacctgt tgtgccccac     2100

ggactgtttt aggaagcatc ctgataccac ttacctcaaa tgcggctctg ggccctggct     2160

cacgccaagg tgcctgatcg actaccccta caggctctgg cattacccct gcacagttaa     2220

ctataccatc ttcaaaataa ggatgtatgt gggaggggtt gagcacaggc tcacggctgc     2280

atgcaatttc actcgtgggg atcgttgcaa cttggaggac agagacagaa gtcaactgtc     2340

tcctttgttg cactccacca cggaatgggc cattttacct tgctcttact cggacctgcc     2400

cgccttgtcg actggtcttc tccacctcca ccaaaacatc gtggacgtac aattcatgta     2460

tggcctatca cctgccctca caaaatacat cgtccgatgg gagtgggtaa tactcttatt     2520

cctgctctta gcggacgcca gggtttgcgc ctgcttatgg atgctcatct tgttgggcca     2580

ggccgaagca gcactagaga agctggtcat cttgcacgct gcgagcgcag ctagctgcaa     2640

tggcttccta tattttgtca tctttttcgt ggctgcttgg tacatcaagg gtcgggtagt     2700

ccccttagct acctattccc tcactggcct gtggtccttt agcctactgc tcctagcatt     2760

gccccaacag gcttatgctt atgacgcatc tgtgcatggc cagataggag cggctctgct     2820

ggtaatgatc actctcttta ctctcacccc cgggtataag acccttctca gccggttttt     2880

gtggtggttg tgctatcttc tgaccctggg ggaagctatg gtccaggagt gggcaccacc     2940

tatgcaggtg cgcggtggcc gtgatggcat catatgggcc gtcgccatat tctacccagg     3000

tgtggtgttt gacataacca agtggctctt ggcggtgctt gggcctgctt acctcctaaa     3060

aggtgctttg acgcgcgtgc cgtacttcgt cagggctcac gctctactga ggatgtgcac     3120

catggcaagg catctcgcgg ggggcaggta cgtccagatg gcgctactag cccttggcag     3180

gtggactggc acttacatct atgaccacct cacccctatg tcggattggg ctgctagtgg     3240

cctgcgggac ctggcggtcg ccgttgagcc tatcatcttc agtccgatgg agaagaaagt     3300

cattgtctgg ggagcggaga cagctgcttg tggggacatt ttacacggac ttcccgtgtc     3360

cgcccgactt ggtcgggagg tcctccttgg cccagctgat ggctatacct ccaaggggtg     3420

gagtcttctc gcccccatca ctgcttacgc ccagcagaca cgtggccttt tgggcaccat     3480

agtggtgagc atgacggggc gcgacaagac agaacaggct ggggaaattc aggtcctgtc     3540

cacagtcact cagtccttcc tcggaacatc catctcgggg gttttgtgga ctgtctacca     3600

tggagctggc aacaagactc tggccggctc acggggtccg gtcacgcaga tgtactccag     3660

tgctgagggg gacttagtag ggtggcccag cccccctggg actaaatctt tggagccgtg     3720

cacgtgtgga gcggtcgacc tgtacctggt cacgcggaac gctgatgtca tcccggctcg     3780

aagacgcggg gacaaacggg gagcgctact ctccccgaga cctctttcca ccttgaaggg     3840

gtcctcagga ggcccggtgc tatgccccag gggccacgct gtcggagtct tccgggcagc     3900

tgtgtgctct cggggcgtgg ctaagtccat agatttcatc cccgttgaga cactcgacat     3960

cgtcacgcgg tcccccacct ttagtgacaa cagcacacca cctgctgtgc cccagaccta     4020

tcaggtcggg tacttgcatg ccccgactgg cagtggaaag agcaccaaag ttcctgtcgc     4080

atatgctgct caggggtata aagtgctagt gcttaatccc tcagtggctg ccaccctggg     4140

gtttggggcg tacttgtcta aggcacatgg catcaatccc aacattagga ctggagtcag     4200

gactgtgacg accggggcgc ccatcacgta ctccacatat ggcaaattcc tcgccgatgg     4260

gggctgtgcg ggcggcgcct acgacatcat catatgtgat gaatgccatg ccgtggactc     4320

taccaccatc cttggcatcg gaacagtcct tgatcaagca gagacagctg gggtcagact     4380

aactgtgctg gctacagcta cgccccctgg gtcagtgaca accccccacc ccaacataga     4440

ggaggtggcc cttgggcagg agggcgagat ccccttctat gggagggcga ttcccctgtc     4500

ttacatcaag ggaggaagac atctgatctt ctgccattca aagaaaaagt gtgacgagct     4560

cgcggcggcc cttcggggta tgggcttgaa ctcagtggca tactacagag ggttggacgt     4620

ctccgtaata ccaactcagg gagacgtagt ggtcgtcgcc accgacgccc tcatgacagg     4680

gtatactggg gactttgact ccgtgatcga ctgcaacgta gcggtcactc aagttgtaga     4740

cttcagttta gaccccacat tcaccataac cacacagatt gtccctcaag acgctgtctc     4800

acgtagccag cgccggggtc gcacgggtag gggaagactg ggcatttata ggtatgtttc     4860

cactggtgag cgagcctcag gaatgtttga cagtgtagtg ctctgtgagt gctacgacgc     4920

aggggccgca tggtatgagc tcacaccatc ggagaccacc gtcaggctca gggcgtattt     4980

caacacgccc ggtttgcctg tgtgccaaga ccatcttgag ttttgggagg cagttttcac     5040

cggcctcaca cacatagatg cccacttcct ttcccaaaca aagcaatcgg gggaaaattt     5100

cgcatactta acagcctacc aggctacagt gtgcgctagg gccaaagccc cccccccgtc     5160

ctgggacgtc atgtggaagt gtttgactcg actcaagccc acactcgtgg gccccacacc     5220

tctcctgtac cgcttgggct ctgttaccaa cgaggtcacc ctcacacatc ccgtgacgaa     5280

atacatcgcc acctgcatgc aagccgacct tgaggtcatg accagcacat gggtcttggc     5340

agggggagtc ttggcggccg tcgccgcgta ttgcctggcg accgggtgtg tttgcatcat     5400

cggccgcttg cacattaacc agcgagccgt cgttgcgccg gacaaggagg tcctctatga     5460

ggcttttgat gagatggagg aatgtgcctc tagggcggct ctcattgaag aggggcagcg     5520

gatagccgag atgctgaagt ccaagatcca aggcttattg cagcaagctt ccaaacaagc     5580

tcaagacata caacccactg tgcaggcttc atggcccaag gtagaacaat tctgggccaa     5640

acacatgtgg aacttcatta gcggcatcca atacctcgca ggactatcaa cactgccagg     5700

gaaccctgca gtagcttcca tgatggcgtt cagtgccgcc ctcaccagtc cgctgtcaac     5760

aagcaccact atccttctca acattttggg gggctggcta gcatcccaaa ttgcaccacc     5820

cgcgggggcc actggcttcg ttgtcagtgg cctagtggga gctgccgtag gcagtatagg     5880

cttaggtaag gtgctagtgg acatcctggc agggtatggt gcgggcattt cgggggctct     5940

cgtcgcattc aagatcatgt ctggcgagaa gccctccatg gaggatgtcg tcaacttgct     6000

gcctggaatt ctgtctccgg gtgccttggt agtgggagtc atctgcgcgg ccattctgcg     6060

ccgacacgtg ggaccggggg aaggcgccgt ccaatggatg aatagactca ttgcctttgc     6120

ttccagagga aatcacgtcg cccccaccca ctacgtgacg gagtcggatg cgtcgcagcg     6180

tgtgacccaa ctacttggct cccttaccat aaccagcctg ctcagaagac tccacaactg     6240

gattactgag gactgcccca tcccatgcgg cggctcgtgg ctccgcgatg tgtgggactg     6300

ggtttgcacc atcctaacag actttaaaaa ttggctgacc tccaaattat tcccaaagat     6360

gcccggcctc ccctttgtct cctgtcaaaa ggggtacaag ggcgtgtggg ccggcactgg     6420

catcatgacc acacggtgtc cttgcggcgc caatatctct ggcaatgtcc gcttgggctc     6480

catgagaatc acggggccta agacctgcat gaatatctgg caggggacct ttcctatcaa     6540

ttgttacacg gagggccagt gcgtgccgaa acccgcgcca aactttaagg tcgccatctg     6600

gagggtggcg gcctcagagt acgcggaggt gacgcagcac gggtcatacc actacataac     6660

aggactcacc actgataact tgaaagtccc ctgccaacta ccctctcccg agttcttttc     6720

ctgggtggac ggagtgcaga tccataggtt tgcccccaca ccgaagccgt ttttccggga     6780

tgaggtctcg ttctgcgttg ggcttaattc atttgtcgtc gggtcccagc ttccttgcga     6840

ccctgaaccc gacacagacg tattgatgtc catgctaaca gatccatctc atatcacggc     6900

ggagactgca gcgcggcgtt tagcgcgggg gtcaccccca tccgaggcaa gctcctcggc     6960

gagccagcta tcggcaccat cgctgcgagc cacctgcacc acccacggca aagcctatga     7020

tgtggacatg gtggatgcta acctgttcat ggggggcgat gtgactcgga tagagtctgg     7080

gtccaaagtg gtcgttctgg actctctcga cccaatggtc gaagaaagga gcgaccttga     7140

gccttcgata ccatcagaat acatgctccc caagaagagg ttcccaccag ctttaccggc     7200

ctgggcacgg cctgattaca acccaccgct tgtggaatcg tggaaaaggc cagattacca     7260

accggccact gttgcgggct gtgctctccc tcctcctagg aaaaccccga cgcctccccc     7320

aaggaggcgc cggacagtgg gcctaagtga ggactccata ggagatgccc ttcaacagct     7380

ggccattaag tcctttggcc agcccccccc aagcggcgat tcaggccttt ccacgggggc     7440

gggcgctgcc gattccggca gtcagacgcc tcctgatgag ttggcccttt cggagacagg     7500

ttccatctct tccatgcccc ccctcgaggg ggagcttgga gatccagacc tggagcctga     7560

gcaggtagag ccccaacccc ccccccaggg gggggtggca gctcccggct cggactcggg     7620

gtcctggtct acttgctccg aggaggacga ctccgtcgtg tgctgctcca tgtcatactc     7680

ctggaccggg gctctaataa ctccttgtag tcccgaagag gagaagttac cgattaaccc     7740

cttgagcaac tccctgttgc gatatcacaa caaggtgtac tgtaccacaa caaagagcgc     7800

ctcactaagg gctaaaaagg taacttttga taggatgcaa gtgctcgact cctactacga     7860

ctcagtctta aaggacatta agctagcggc ctccaaggtc accgcaaggc tcctcaccat     7920

ggaggaggct tgccagttaa ccccacccca ttctgcaaga tctaaatatg ggtttggggc     7980

taaggaggtc cgcagcttgt ccgggagggc cgttaaccac atcaagtccg tgtggaagga     8040

cctcctggag gactcagaaa caccaattcc cacaaccatt atggccaaaa atgaggtgtt     8100

ctgcgtggac cccaccaagg ggggcaagaa agcagctcgc cttatcgttt accctgacct     8160

cggcgtcagg gtctgcgaga agatggccct ttatgacatt acacaaaaac ttcctcaggc     8220

ggtgatgggg gcttcttatg gattccagta ttcccccgct cagcgggtag agtttctctt     8280

gaaagcatgg gcggaaaaga aggaccctat gggtttttcg tatgataccc gatgctttga     8340

ctcaaccgtc actgagagag acatcaggac tgaggagtcc atatatcggg cctgctcctt     8400

gcccgaggag gcccacactg ccatacactc gctaactgag agactttacg tgggagggcc     8460

tatgttcaac agcaagggcc aaacctgcgg gtacaggcgt tgccgcgcca gcggggtgct     8520

caccactagc atggggaaca ccatcacatg ctacgtgaaa gccttagcgg cttgtaaagc     8580

tgcagggata atcgcgccca caatgctggt atgcggcgat gacttggttg tcatctcaga     8640

aagccagggg accgaggagg acgagcggaa cctgagagcc ttcacggagg ctatgaccag     8700

gtattctgcc cctcctggtg acccccccag accggagtat gatctggagc tgataacatc     8760

ttgctcctca aatgtgtctg tggcgctggg cccacaaggc cgccgcagat actacctgac     8820

cagagaccct accactccaa tcgcccgggc tgcctgggaa acagttagac actcccctgt     8880

caattcatgg ctgggaaaca tcatccagta cgccccgacc atatgggctc gcatggtcct     8940

gatgacacac ttcttctcca ttctcatggc tcaagacacg ctggaccaga acctcaactt     9000

tgagatgtac ggagcggtgt actccgtgag tcccttggac ctcccagcta taattgaaag     9060

gttacatggg cttgacgctt tttctatgca cacatacact caccacgaac tgacacgggt     9120

ggcttcagcc ctcagaaaac ttggggcgcc acccctcaga gcgtggaaga gccgggcacg     9180

tgcagtcagg gcgtccctca tctcccgtgg ggggaaagcg gccgtttgcg gtcgatatct     9240

cttcaattgg gcggtgaaga ccaagctcaa actcactcca ttgccggaag cgcgcctcct     9300

ggatttatcc agctggttca ccgtcggcgc cggcgggggc gacatttttc acagcgtgtc     9360

gcgtgcccga ccccgcttat tgctctttgg cctactccta ctttttgtag gggtaggcct     9420

tttcctactc cccgctcggt agagcggcac acattagcta cactccatag ctaactgtcc     9480

cttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt     9540

tttttttttt tttttttttt tttttctttt tttctctttt ccttctttct taccttattt     9600

tactttcttt cctggtggct ccatcttagc cctagtcacg gctagctgtg aaaggtccgt     9660

gagccgcatg actgcagaga gtgccgtaac tggtctctct gcagatcatg t              9711


<210>  24
<211>  9678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  24
acccgcccct aataggggcg acactccgcc atgaatcact cccctgtgag gaactactgt       60

cttcacgcag aaagcgtcta gccatggcgt tagtatgagt gtcgtacagc ctccaggccc      120

ccccctcccg ggagagccat agtggtctgc ggaaccggtg agtacaccgg aattgccggg      180

aagactgggt cctttcttgg ataaacccac tctatgcccg gccatttggg cgtgcccccg      240

caagactgct agccgagtag cgttgggttg cgaaaggcct tgtggtactg cctgataggg      300

tgcttgcgag tgccccggga ggtctcgtag accgtgcacc atgagcacaa atcctaaacc      360

tcaaagaaaa accaaaagaa acaccaaccg tcgcccacaa gacgttaagt ttccgggcgg      420

cggccagatc gttggcggag tatacttgtt gccgcgcagg ggccccaggt tgggtgtgcg      480

cgcgacaagg aagacttcgg agcggtccca gccacgtgga aggcgccagc ccatccctaa      540

agatcggcgc tccactggca aatcctgggg aaaaccagga tacccctggc ccctatacgg      600

gaatgaggga ctcggctggg caggatggct cctgtccccc cgaggttccc gtccctcttg      660

gggccccaat gacccccggc ataggtcgcg caacgtgggt aaggtcatcg ataccctaac      720

gtgcggcttt gccgacctca tggggtacat ccctgtcgtg ggcgccccgc tcggcggcgt      780

cgccagagct ctcgcgcatg gcgtgagagt cctggaggac ggggttaatt ttgcaacagg      840

gaacttaccc ggttgctcct tttctatctt cttgctggcc ctgctgtcct gcatcaccac      900

cccggtctcc gctgccgaag tgaagaacat cagtaccggc tacatggtga ctaacgactg      960

caccaatgac agcattacct ggcagctcca ggctgctgtc ctccacgtcc ccgggtgcgt     1020

cccgtgcgag aaagtgggga atgcatctca gtgctggata ccggtctcac cgaatgtggc     1080

cgtgcagcgg cccggcgccc tcacgcaggg cttgcggacg cacatcgaca tggttgtgat     1140

gtccgccacg ctctgctctg ccctctacgt gggggacctc tgcggtgggg tgatgctcgc     1200

agcccaaatg ttcattgtct cgccgcagca ccactggttt gtccaagact gcaattgctc     1260

catctaccct ggtaccatca ctggacaccg catggcatgg gacatgatga tgaactggtc     1320

gcccacggct accatgatct tggcgtacgc gatgcgtgtc cccgaggtca ttatagacat     1380

cattagcggg gctcattggg gcgtcatgtt cggcttggcc tacttctcta tgcagggagc     1440

gtgggcgaaa gtcgttgtca tccttctgtt ggccgccggg gtggacgcgc gcacccatac     1500

tgttgggggt tctgccgcgc agaccaccgg gcgcctcacc agcttatttg acatgggccc     1560

caggcagaaa atccagctcg ttaacaccaa tggcagctgg cacatcaacc gcaccgccct     1620

gaactgcaat gactccttgc acaccggctt tatcgcgtct ctgttctaca cccacagctt     1680

caactcgtca ggatgtcccg aacgcatgtc cgcctgccgc agtatcgagg ccttccgggt     1740

gggatggggc gccttgcaat atgaggataa tgtcaccaat ccagaggata tgagacccta     1800

ttgctggcac tacccaccaa ggcagtgtgg cgtggtctcc gcgaagactg tgtgtggccc     1860

agtgtactgt ttcaccccca gcccagtggt agtgggcacg accgacaggc ttggagcgcc     1920

cacttacacg tggggggaga atgagacaga tgtcttccta ttgaacagca ctcgaccacc     1980

gctggggtca tggttcggct gcacgtggat gaactcttct ggctacacca agacttgcgg     2040

cgcaccaccc tgccgtacta gagctgactt caacgccagc acggacctgt tgtgccccac     2100

ggactgtttt aggaagcatc ctgataccac ttacctcaaa tgcggctctg ggccctggct     2160

cacgccaagg tgcctgatcg actaccccta caggctctgg cattacccct gcacagttaa     2220

ctataccatc ttcaaaataa ggatgtatgt gggaggggtt gagcacaggc tcacggctgc     2280

atgcaatttc actcgtgggg atcgttgcaa cttggaggac agagacagaa gtcaactgtc     2340

tcctttgttg cactccacca cggaatgggc cattttacct tgctcttact cggacctgcc     2400

cgccttgtcg actggtcttc tccacctcca ccaaaacatc gtggacgtac aattcatgta     2460

tggcctatca cctgccctca caaaatacat cgtccgatgg gagtgggtaa tactcttatt     2520

cctgctctta gcggacgcca gggtttgcgc ctgcttatgg atgctcatct tgttgggcca     2580

ggccgaagca gcactagaga agctggtcat cttgcacgct gcgagcgcag ctagctgcaa     2640

tggcttccta tattttgtca tctttttcgt ggctgcttgg tacatcaagg gtcgggtagt     2700

ccccttagct acctattccc tcactggcct gtggtccttt agcctactgc tcctagcatt     2760

gccccaacag gcttatgctt atgacgcatc tgtgcatggc cagataggag cggctctgct     2820

ggtaatgatc actctcttta ctctcacccc cgggtataag acccttctca gccggttttt     2880

gtggtggttg tgctatcttc tgaccctggg ggaagctatg gtccaggagt gggcaccacc     2940

tatgcaggtg cgcggtggcc gtgatggcat catatgggcc gtcgccatat tctacccagg     3000

tgtggtgttt gacataacca agtggctctt ggcggtgctt gggcctgctt acctcctaaa     3060

aggtgctttg acgcgcgtgc cgtacttcgt cagggctcac gctctactga ggatgtgcac     3120

catggcaagg catctcgcgg ggggcaggta cgtccagatg gcgctactag cccttggcag     3180

gtggactggc acttacatct atgaccacct cacccctatg tcggattggg ctgctagtgg     3240

cctgcgggac ctggcggtcg ccgttgagcc tatcatcttc agtccgatgg agaagaaagt     3300

cattgtctgg ggagcggaga cagctgcttg tggggacatt ttacacggac ttcccgtgtc     3360

cgcccgactt ggtcgggagg tcctccttgg cccagctgat ggctatacct ccaaggggtg     3420

gagtcttctc gcccccatca ctgcttacgc ccagcagaca cgtggccttt tgggcaccat     3480

agtggtgagc atgacggggc gcgacaagac agaacaggct ggggaaattc aggtcctgtc     3540

cacagtcact cagtccttcc tcggaacatc catctcgggg gttttgtgga ctgtctacca     3600

tggagctggc aacaagactc tggccggctc acggggtccg gtcacgcaga tgtactccag     3660

tgctgagggg gacttagtag ggtggcccag cccccctggg actaaatctt tggagccgtg     3720

cacgtgtgga gcggtcgacc tgtacctggt cacgcggaac gctgatgtca tcccggctcg     3780

aagacgcggg gacaaacggg gagcgctact ctccccgaga cctctttcca ccttgaaggg     3840

gtcctcagga ggcccggtgc tatgccccag gggccacgct gtcggagtct tccgggcagc     3900

tgtgtgctct cggggcgtgg ctaagtccat agatttcatc cccgttgaga cactcgacat     3960

cgtcacgcgg tcccccacct ttagtgacaa cagcacacca cctgctgtgc cccagaccta     4020

tcaggtcggg tacttgcatg ccccgactgg cagtggaaag agcaccaaag ttcctgtcgc     4080

atatgctgct caggggtata aagtgctagt gcttaatccc tcagtggctg ccaccctggg     4140

gtttggggcg tacttgtcta aggcacatgg catcaatccc aacattagga ctggagtcag     4200

gactgtgacg accggggcgc ccatcacgta ctccacatat ggcaaattcc tcgccgatgg     4260

gggctgtgcg ggcggcgcct acgacatcat catatgtgat gaatgccatg ccgtggactc     4320

taccaccatc cttggcatcg gaacagtcct tgatcaagca gagacagctg gggtcagact     4380

aactgtgctg gctacagcta cgccccctgg gtcagtgaca accccccacc ccaacataga     4440

ggaggtggcc cttgggcagg agggcgagat ccccttctat gggagggcga ttcccctgtc     4500

ttacatcaag ggaggaagac atctgatctt ctgccattca aagaaaaagt gtgacgagct     4560

cgcggcggcc cttcggggta tgggcttgaa ctcagtggca tactacagag ggttggacgt     4620

ctccgtaata ccaactcagg gagacgtagt ggtcgtcgcc accgacgccc tcatgacagg     4680

gtatactggg gactttgact ccgtgatcga ctgcaacgta gcggtcactc aagttgtaga     4740

cttcagttta gaccccacat tcaccataac cacacagatt gtccctcaag acgctgtctc     4800

acgtagccag cgccggggtc gcacgggtag gggaagactg ggcatttata ggtatgtttc     4860

cactggtgag cgagcctcag gaatgtttga cagtgtagtg ctctgtgagt gctacgacgc     4920

aggggccgca tggtatgagc tcacaccatc ggagaccacc gtcaggctca gggcgtattt     4980

caacacgccc ggtttgcctg tgtgccaaga ccatcttgag ttttgggagg cagttttcac     5040

cggcctcaca cacatagatg cccacttcct ttcccaaaca aagcaatcgg gggaaaattt     5100

cgcatactta acagcctacc aggctacagt gtgcgctagg gccaaagccc cccccccgtc     5160

ctgggacgtc atgtggaagt gtttgactcg actcaagccc acactcgtgg gccccacacc     5220

tctcctgtac cgcttgggct ctgttaccaa cgaggtcacc ctcacacatc ccgtgacgaa     5280

atacatcgcc acctgcatgc aagccgacct tgaggtcatg accagcacat gggtcttggc     5340

agggggagtc ttggcggccg tcgccgcgta ttgcctggcg accgggtgtg tttgcatcat     5400

cggccgcttg cacattaacc agcgagccgt cgttgcgccg gacaaggagg tcctctatga     5460

ggcttttgat gagatggagg aatgtgcctc tagggcggct ctcattgaag aggggcagcg     5520

gatagccgag atgctgaagt ccaagatcca aggcttattg cagcaagctt ccaaacaagc     5580

tcaagacata caacccactg tgcaggcttc atggcccaag gtagaacaat tctgggccaa     5640

acacatgtgg aacttcatta gcggcatcca atacctcgca ggactatcaa cactgccagg     5700

gaaccctgca gtagcttcca tgatggcgtt cagtgccgcc ctcaccagtc cgctgtcaac     5760

aagcaccact atccttctca acattttggg gggctggcta gcatcccaaa ttgcaccacc     5820

cgcgggggcc actggcttcg ttgtcagtgg cctagtggga gctgccgtag gcagtatagg     5880

cttaggtaag gtgctagtgg acatcctggc agggtatggt gcgggcattt cgggggctct     5940

cgtcgcattc aagatcatgt ctggcgagaa gccctccatg gaggatgtcg tcaacttgct     6000

gcctggaatt ctgtctccgg gtgccttggt agtgggagtc atctgcgcgg ccattctgcg     6060

ccgacacgtg ggaccggggg aaggcgccgt ccaatggatg aatagactca ttgcctttgc     6120

ttccagagga aatcacgtcg cccccaccca ctacgtgacg gagtcggatg cgtcgcagcg     6180

tgtgacccaa ctacttggct cccttaccat aaccagcctg ctcagaagac tccacaactg     6240

gattactgag gactgcccca tcccatgcgg cggctcgtgg ctccgcgatg tgtgggactg     6300

ggtttgcacc atcctaacag actttaaaaa ttggctgacc tccaaattat tcccaaagat     6360

gcccggcctc ccctttgtct cctgtcaaaa ggggtacaag ggcgtgtggg ccggcactgg     6420

catcatgacc acacggtgtc cttgcggcgc caatatctct ggcaatgtcc gcttgggctc     6480

catgagaatc acggggccta agacctgcat gaatatctgg caggggacct ttcctatcaa     6540

ttgttacacg gagggccagt gcgtgccgaa acccgcgcca aactttaagg tcgccatctg     6600

gagggtggcg gcctcagagt acgcggaggt gacgcagcac gggtcatacc actacataac     6660

aggactcacc actgataact tgaaagtccc ctgccaacta ccctctcccg agttcttttc     6720

ctgggtggac ggagtgcaga tccataggtt tgcccccaca ccgaagccgt ttttccggga     6780

tgaggtctcg ttctgcgttg ggcttaattc atttgtcgtc gggtcccagc ttccttgcga     6840

ccctgaaccc gacacagacg tattgatgtc catgctaaca gatccatctc atatcacggc     6900

ggagactgca gcgcggcgtt tagcgcgggg gtcaccccca tccgaggcaa gctcctcggc     6960

gagccagcta tcggcaccat cgctgcgagc cacctgcacc acccacggca aagcctatga     7020

tgtggacatg gtggatgcta acctgttcat ggggggcgat gtgactcgga tagagtctgg     7080

gtccaaagtg gtcgttctgg actctctcga cccaatggtc gaagaaagga gcgaccttga     7140

gccttcgata ccatcagaat acatgctccc caagaagagg ttcccaccag ctttaccggc     7200

ctgggcacgg cctgattaca acccaccgct tgtggaatcg tggaaaaggc cagattacca     7260

accggccact gttgcgggct gtgctctccc tcctcctagg aaaaccccga cgcctccccc     7320

aaggaggcgc cggacagtgg gcctaagtga ggactccata ggagatgccc ttcaacagct     7380

ggccattaag tcctttggcc agcccccccc aagcggcgat tcaggccttt ccacgggggc     7440

gggcgctgcc gattccggca gtcagacgcc tcctgatgag ttggcccttt cggagacagg     7500

ttccatctct tccatgcccc ccctcgaggg ggagcttgga gatccagacc tggagcctga     7560

gcaggtagag ccccaacccc ccccccaggg gggggtggca gctcccggct cggactcggg     7620

gtcctggtct acttgctccg aggaggacga ctccgtcgtg tgctgctcca tgtcatactc     7680

ctggaccggg gctctaataa ctccttgtag tcccgaagag gagaagttac cgattaaccc     7740

cttgagcaac tccctgttgc gatatcacaa caaggtgtac tgtaccacaa caaagagcgc     7800

ctcactaagg gctaaaaagg taacttttga taggatgcaa gtgctcgact cctactacga     7860

ctcagtctta aaggacatta agctagcggc ctccaaggtc accgcaaggc tcctcaccat     7920

ggaggaggct tgccagttaa ccccacccca ttctgcaaga tctaaatatg ggtttggggc     7980

taaggaggtc cgcagcttgt ccgggagggc cgttaaccac atcaagtccg tgtggaagga     8040

cctcctggag gactcagaaa caccaattcc cacaaccatt atggccaaaa atgaggtgtt     8100

ctgcgtggac cccaccaagg ggggcaagaa agcagctcgc cttatcgttt accctgacct     8160

cggcgtcagg gtctgcgaga agatggccct ttatgacatt acacaaaaac ttcctcaggc     8220

ggtgatgggg gcttcttatg gattccagta ttcccccgct cagcgggtag agtttctctt     8280

gaaagcatgg gcggaaaaga aggaccctat gggtttttcg tatgataccc gatgctttga     8340

ctcaaccgtc actgagagag acatcaggac tgaggagtcc atatatcggg cctgctcctt     8400

gcccgaggag gcccacactg ccatacactc gctaactgag agactttacg tgggagggcc     8460

tatgttcaac agcaagggcc aaacctgcgg gtacaggcgt tgccgcgcca gcggggtgct     8520

caccactagc atggggaaca ccatcacatg ctacgtgaaa gccttagcgg cttgtaaagc     8580

tgcagggata atcgcgccca caatgctggt atgcggcgat gacttggttg tcatctcaga     8640

aagccagggg accgaggagg acgagcggaa cctgagagcc ttcacggagg ctatgaccag     8700

gtattctgcc cctcctggtg acccccccag accggagtat gatctggagc tgataacatc     8760

ttgctcctca aatgtgtctg tggcgctggg cccacaaggc cgccgcagat actacctgac     8820

cagagaccct accactccaa tcgcccgggc tgcctgggaa acagttagac actcccctgt     8880

caattcatgg ctgggaaaca tcatccagta cgccccgacc atatgggctc gcatggtcct     8940

gatgacacac ttcttctcca ttctcatggc tcaagacacg ctggaccaga acctcaactt     9000

tgagatgtac ggagcggtgt actccgtgag tcccttggac ctcccagcta taattgaaag     9060

gttacatggg cttgacgctt tttctctgca cacatacact ccccacgaac tgacacgggt     9120

ggcttcagcc ctcagaaaac ttggggcgcc acccctcaga gcgtggaaga gccgggcacg     9180

tgcagtcagg gcgtccctca tctcccgtgg ggggagagcg gccgtttgcg gtcgatatct     9240

cttcaattgg gcggtgaaga ccaagctcaa actcactcca ttgccggaag cgcgcctcct     9300

ggatttatcc agctggttca ccgtcggcgc cggcgggggc gacatttatc acagcgtgtc     9360

gcgtgcccga ccccgcttat tgctctttgg cctactccta ctttttgtag gggtaggcct     9420

tttcctactc cccgctcggt agagcggcac acattagcta cactccatag ctaactgtcc     9480

cttttttttt tttttttttt tttttttttt tttttttttt tttttttttt ttcttttttt     9540

ctcttttcct tctttcttac cttattttac tttctttcct ggtggctcca tcttagccct     9600

agtcacggct agctgtgaaa ggtccgtgag ccgcatgact gcagagagtg ccgtaactgg     9660

tctctctgca gatcatgt                                                   9678


<210>  25
<211>  9678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  25
acccgcccct aataggggcg acactccgcc atgaatcact cccctgtgag gaactactgt       60

cttcacgcag aaagcgtcta gccatggcgt tagtatgagt gtcgtacagc ctccaggccc      120

ccccctcccg ggagagccat agtggtctgc ggaaccggtg agtacaccgg aattgccggg      180

aagactgggt cctttcttgg ataaacccac tctatgcccg gccatttggg cgtgcccccg      240

caagactgct agccgagtag cgttgggttg cgaaaggcct tgtggtactg cctgataggg      300

tgcttgcgag tgccccggga ggtctcgtag accgtgcacc atgagcacaa atcctaaacc      360

tcaaagaaaa accaaaagaa acaccaaccg tcgcccacaa gacgttaagt ttccgggcgg      420

cggccagatc gttggcggag tatacttgtt gccgcgcagg ggccccaggt tgggtgtgcg      480

cgcgacaagg aagacttcgg agcggtccca gccacgtgga aggcgccagc ccatccctaa      540

agatcggcgc tccactggca aatcctgggg aaaaccagga tacccctggc ccctatacgg      600

gaatgaggga ctcggctggg caggatggct cctgtccccc cgaggttccc gtccctcttg      660

gggccccaat gacccccggc ataggtcgcg caacgtgggt aaggtcatcg ataccctaac      720

gtgcggcttt gccgacctca tggggtacat ccctgtcgtg ggcgccccgc tcggcggcgt      780

cgccagagct ctcgcgcatg gcgtgagagt cctggaggac ggggttaatt ttgcaacagg      840

gaacttaccc ggttgctcct tttctatctt cttgctggcc ctgctgtcct gcatcaccac      900

cccggtctcc gctgccgaag tgaagaacat cagtaccggc tacatggtga ctaacgactg      960

caccaatgac agcattacct ggcagctcca ggctgctgtc ctccacgtcc ccgggtgcgt     1020

cccgtgcgag aaagtgggga atgcatctca gtgctggata ccggtctcac cgaatgtggc     1080

cgtgcagcgg cccggcgccc tcacgcaggg cttgcggacg cacatcgaca tggttgtgat     1140

gtccgccacg ctctgctctg ccctctacgt gggggacctc tgcggtgggg tgatgctcgc     1200

agcccaaatg ttcattgtct cgccgcagca ccactggttt gtccaagact gcaattgctc     1260

catctaccct ggtaccatca ctggacaccg catggcatgg gacatgatga tgaactggtc     1320

gcccacggct accatgatct tggcgtacgc gatgcgtgtc cccgaggtca ttatagacat     1380

cattagcggg gctcattggg gcgtcatgtt cggcttggcc tacttctcta tgcagggagc     1440

gtgggcgaaa gtcgttgtca tccttctgtt ggccgccggg gtggacgcgc gcacccatac     1500

tgttgggggt tctgccgcgc agaccaccgg gcgcctcacc agcttatttg acatgggccc     1560

caggcagaaa atccagctcg ttaacaccaa tggcagctgg cacatcaacc gcaccgccct     1620

gaactgcaat gactccttgc acaccggctt tatcgcgtct ctgttctaca cccacagctt     1680

caactcgtca ggatgtcccg aacgcatgtc cgcctgccgc agtatcgagg ccttccgggt     1740

gggatggggc gccttgcaat atgaggataa tgtcaccaat ccagaggata tgagacccta     1800

ttgctggcac tacccaccaa ggcagtgtgg cgtggtctcc gcgaagactg tgtgtggccc     1860

agtgtactgt ttcaccccca gcccagtggt agtgggcacg accgacaggc ttggagcgcc     1920

cacttacacg tggggggaga atgagacaga tgtcttccta ttgaacagca ctcgaccacc     1980

gctggggtca tggttcggct gcacgtggat gaactcttct ggctacacca agacttgcgg     2040

cgcaccaccc tgccgtacta gagctgactt caacgccagc acggacctgt tgtgccccac     2100

ggactgtttt aggaagcatc ctgataccac ttacctcaaa tgcggctctg ggccctggct     2160

cacgccaagg tgcctgatcg actaccccta caggctctgg cattacccct gcacagttaa     2220

ctataccatc ttcaaaataa ggatgtatgt gggaggggtt gagcacaggc tcacggctgc     2280

atgcaatttc actcgtgggg atcgttgcaa cttggaggac agagacagaa gtcaactgtc     2340

tcctttgttg cactccacca cggaatgggc cattttacct tgctcttact cggacctgcc     2400

cgccttgtcg actggtcttc tccacctcca ccaaaacatc gtggacgtac aattcatgta     2460

tggcctatca cctgccctca caaaatacat cgtccgatgg gagtgggtaa tactcttatt     2520

cctgctctta gcggacgcca gggtttgcgc ctgcttatgg atgctcatct tgttgggcca     2580

ggccgaagca gcactagaga agctggtcat cttgcacgct gcgagcgcag ctagctgcaa     2640

tggcttccta tattttgtca tctttttcgt ggctgcttgg tacatcaagg gtcgggtagt     2700

ccccttagct acctattccc tcactggcct gtggtccttt agcctactgc tcctagcatt     2760

gccccaacag gcttatgctt atgacgcatc tgtgcatggc cagataggag cggctctgct     2820

ggtaatgatc actctcttta ctctcacccc cgggtataag acccttctca gccggttttt     2880

gtggtggttg tgctatcttc tgaccctggg ggaagctatg gtccaggagt gggcaccacc     2940

tatgcaggtg cgcggtggcc gtgatggcat catatgggcc gtcgccatat tctacccagg     3000

tgtggtgttt gacataacca agtggctctt ggcggtgctt gggcctgctt acctcctaaa     3060

aggtgctttg acgcgcgtgc cgtacttcgt cagggctcac gctctactga ggatgtgcac     3120

catggcaagg catctcgcgg ggggcaggta cgtccagatg gcgctactag cccttggcag     3180

gtggactggc acttacatct atgaccacct cacccctatg tcggattggg ctgctagtgg     3240

cctgcgggac ctggcggtcg ccgttgagcc tatcatcttc agtccgatgg agaagaaagt     3300

cattgtctgg ggagcggaga cagctgcttg tggggacatt ttacacggac ttcccgtgtc     3360

cgcccgactt ggtcgggagg tcctccttgg cccagctgat ggctatacct ccaaggggtg     3420

gagtcttctc gcccccatca ctgcttacgc ccagcagaca cgtggccttt tgggcaccat     3480

agtggtgagc atgacggggc gcgacaagac agaacaggct ggggaaattc aggtcctgtc     3540

cacagtcact cagtccttcc tcggaacatc catctcgggg gttttgtgga ctgtctacca     3600

tggagctggc aacaagactc tggccggctc acggggtccg gtcacgcaga tgtactccag     3660

tgctgagggg gacttagtag ggtggcccag cccccctggg actaaatctt tggagccgtg     3720

cacgtgtgga gcggtcgacc tgtacctggt cacgcggaac gctgatgtca tcccggctcg     3780

aagacgcggg gacaaacggg gagcgctact ctccccgaga cctctttcca ccttgaaggg     3840

gtcctcagga ggcccggtgc tatgccccag gggccacgct gtcggagtct tccgggcagc     3900

tgtgtgctct cggggcgtgg ctaagtccat agatttcatc cccgttgaga cactcgacat     3960

cgtcacgcgg tcccccacct ttagtgacaa cagcacacca cctgctgtgc cccagaccta     4020

tcaggtcggg tacttgcatg ccccgactgg cagtggaaag agcaccaaag ttcctgtcgc     4080

atatgctgct caggggtata aagtgctagt gcttaatccc tcagtggctg ccaccctggg     4140

gtttggggcg tacttgtcta aggcacatgg catcaatccc aacattagga ctggagtcag     4200

gactgtgacg accggggcgc ccatcacgta ctccacatat ggcaaattcc tcgccgatgg     4260

gggctgtgcg ggcggcgcct acgacatcat catatgtgat gaatgccatg ccgtggactc     4320

taccaccatc cttggcatcg gaacagtcct tgatcaagca gagacagctg gggtcagact     4380

aactgtgctg gctacagcta cgccccctgg gtcagtgaca accccccacc ccaacataga     4440

ggaggtggcc cttgggcagg agggcgagat ccccttctat gggagggcga ttcccctgtc     4500

ttacatcaag ggaggaagac atctgatctt ctgccattca aagaaaaagt gtgacgagct     4560

cgcggcggcc cttcggggta tgggcttgaa ctcagtggca tactacagag ggttggacgt     4620

ctccgtaata ccaactcagg gagacgtagt ggtcgtcgcc accgacgccc tcatgacagg     4680

gtatactggg gactttgact ccgtgatcga ctgcaacgta gcggtcactc aagttgtaga     4740

cctcagttta gaccccacat tcaccataac cacacagatt gtccctcaag acgctgtctc     4800

acgtagccag cgccggggtc gcacgggtag gggaagactg ggcatttata ggtatgtttc     4860

cactggtgag cgagcctcag gaatgtttga cagtgtagtg ctctgtgagt gctacgacgc     4920

aggggccgca tggtatgagc tcacaccatc ggagaccacc gtcaggctca gggcgtattt     4980

caacacgccc ggtttgcctg tgtgccaaga ccatcttgag ttttgggagg cagttttcac     5040

cggcctcaca cacatagatg cccacttcct ttcccaaaca aagcaatcgg gggaaaattt     5100

cgcatactta acagcctacc aggctacagt gtgcgctagg gccaaagccc cccccccgtc     5160

ctgggacgtc atgtggaagt gtttgactcg actcaagccc acactcgtgg gccccacacc     5220

tctcctgtac cgcttgggct ctgttaccaa cgaggtcacc ctcacacatc ccgtgacgaa     5280

atacatcgcc acctgcatgc aagccgacct tgaggtcatg accagcacat gggtcttggc     5340

agggggagtc ttggcggccg tcgcctcgta ttgcctggcg accgggtgtg tttgcatcat     5400

cggccgcttg cacattaacc agcgagccgt cgttgcgccg gacaaggagg tcctctatga     5460

ggcttttgat gagatggagg aatgtgcctc tagggcggct ctcattgaag aggggcagcg     5520

gatagccgag atgctgaagt ccaagatcca aggcttattg cagcaagctt ccaaacaagc     5580

tcaagacata caacccactg tgcaggcttc atggcccaag gtagaacaat tctgggccaa     5640

acacatgtgg aacttcatta gcggcatcca atacctcgca ggactatcaa cactgccagg     5700

gaaccctgca gtagcttcca tgatggcgtt cagtgccgcc ctcaccagtc cgctgtcaac     5760

aagcaccact atccttctca acattttggg gggctggcta gcatcccaaa ttgcaccacc     5820

cgcgggggcc actggcttcg ttgtcagtgg cctagtggga gctgccgtag gcagtatagg     5880

cttaggtaag gtgctagtgg acatcctggc agggtatggt gcgggcattt cgggggctct     5940

cgtcgcattc aagatcatgt ctggcgagaa gccctccatg gaggatgtcg tcaacttgct     6000

gcctggaatt ctgtctccgg gtgccttggt agtgggagtc atctgcgcgg ccattctgcg     6060

ccgacacgtg ggaccggggg aaggcgccgt ccaatggatg aatagactca ttgcctttgc     6120

ttccagagga aatcacgtcg cccccaccca ctacgtgacg gagtcggatg cgtcgcagcg     6180

tgtgacccaa ctacttggct cccttaccat aaccagcctg ctcagaagac tccacaactg     6240

gattactgag gactgcccca tcccatgcgg cggctcgtgg ctccgcgatg tgtgggactg     6300

ggtttgcacc atcctaacag actttaaaaa ttggctgacc tccaaattat tcccaaagat     6360

gcccggcctc ccctttgtct cctgtcaaaa ggggtacaag ggcgtgtggg ccggcactgg     6420

catcatgacc acacggtgtc cttgcggcgc caatatctct ggcaatgtcc gcttgggctc     6480

catgagaatc acggggccta agacctgcat gaatatctgg caggggacct ttcctatcaa     6540

ttgttacacg gagggccagt gcgtgccgaa acccgcgcca aactttaagg tcgccatctg     6600

gagggtggcg gcctcagagt acgcggaggt gacgcagcac gggtcatacc actacataac     6660

aggactcacc actgataact tgaaagtccc ctgccaacta ccctctcccg agttcttttc     6720

ctgggtggac ggagtgcaga tccataggtt tgcccccaca ccgaagccgt ttttccggga     6780

tgaggtctcg ttctgcgttg ggcttaattc atttgtcgtc gggtcccagc ttccttgcga     6840

ccctgaaccc gacacagacg tattgatgtc catgctaaca gatccatctc atatcacggc     6900

ggagactgca gcgcggcgtt tagcgcgggg gtcaccccca tccgaggcaa gctcctcggc     6960

gagccagcta tcggcaccat cgctgcgagc cacctgcacc acccacggca aagcctatga     7020

tgtggacatg gtggatgcta acctgttcat ggggggcgat gtgactcgga tagagtctgg     7080

gtccaaagtg gtcgttctgg actctctcga cccaatggtc gaagaaagga gcgaccttga     7140

gccttcgata ccatcagaat acatgctccc caagaagagg ttcccaccag ctttaccggc     7200

ctgggcacgg cctgattaca acccaccgct tgtggaatcg tggaaaaggc cagattacca     7260

accggccact gttgcgggct gtgctctccc tcctcctagg aaaaccccga cgcctccccc     7320

aaggaggcgc cggacagtgg gcctaagtga ggactccata ggagatgccc ttcaacagct     7380

ggccattaag tcctttggcc agcccccccc aagcggcgat tcaggccttt ccacgggggc     7440

gggcgctgcc gattccggca gtcagacgcc tcctgatgag ttggcccttt cggagacagg     7500

ttccatctct tccatgcccc ccctcgaggg ggagcttgga gatccagacc tggagcctga     7560

gcaggtagag ccccaacccc ccccccaggg gggggtggca gctcccggct cggactcggg     7620

gtcctggtct acttgctccg aggaggacga ctccgtcgtg tgctgctcca tgtcatactc     7680

ctggaccggg gctctaataa ctccttgtag tcccgaagag gagaagttac cgattaaccc     7740

cttgagcaac tccctgttgc gatatcacaa caaggtgtac tgtaccacaa caaagagcgc     7800

ctcactaagg gctaaaaagg taacttttga taggatgcaa gtgctcgact cctactacga     7860

ctcagtctta aaggacatta agctagcggc ctccaaggtc accgcaaggc tcctcaccat     7920

ggaggaggct tgccagttaa ccccacccca ttctgcaaga tctaaatatg ggtttggggc     7980

taaggaggtc cgcagcttgt ccgggagggc cgttaaccac atcaagtccg tgtggaagga     8040

cctcctggag gactcagaaa caccaattcc cacaaccatt atggccaaaa atgaggtgtt     8100

ctgcgtggac cccaccaagg ggggcaagaa agcagctcgc cttatcgttt accctgacct     8160

cggcgtcagg gtctgcgaga agatggccct ttatgacatt acacaaaaac ttcctcaggc     8220

ggtgatgggg gcttcttatg gattccagta ttcccccgct cagcgggtag agtttctctt     8280

gaaagcatgg gcggaaaaga aggaccctat gggtttttcg tatgataccc gatgctttga     8340

ctcaaccgtc actgagagag acatcaggac tgaggagtcc atatatcggg cctgctcctt     8400

gcccgaggag gcccacactg ccatacactc gctaactgag agactttacg tgggagggcc     8460

tatgttcaac agcaagggcc aaacctgcgg gtacaggcgt tgccgcgcca gcggggtgct     8520

caccactagc atggggaaca ccatcacatg ctacgtgaaa gccttagcgg cttgtaaagc     8580

tgcagggata atcgcgccca caatgctggt atgcggcgat gacttggttg tcatctcaga     8640

aagccagggg accgaggagg acgagcggaa cctgagagcc ttcacggagg ctatgaccag     8700

gtattctgcc cctcctggtg acccccccag accggagtat gatctggagc tgataacatc     8760

ttgctcctca aatgtgtctg tggcgctggg cccacaaggc cgccgcagat actacctgac     8820

cagagaccct accactccaa tcgcccgggc tgcctgggaa acagttagac actcccctgt     8880

caattcatgg ctgggaaaca tcatccagta cgccccgacc atatgggctc gcatggtcct     8940

gatgacacac ttcttctcca ttctcatggc tcaagacacg ctggaccaga acctcaactt     9000

tgagatgtac ggagcggtgt actccgtgag tcccttggac ctcccagcta taattgaaag     9060

gttacatggg cttgacgctt tttctctgca cacatacact ccccacgaac tgacacgggt     9120

ggcttcagcc ctcagaaaac ttggggcgcc acccctcaga gcgtggaaga gccgggcacg     9180

tgcagtcagg gcgtccctca tctcccgtgg ggggagagcg gccgtttgcg gtcgatatct     9240

cttcaattgg gcggtgaaga ccaagctcaa actcactcca ttgccggaag cgcgcctcct     9300

ggatttatcc agctggttca ccgtcggcgc cggcgggggc ggcatttatc acagcgtgtc     9360

gcgtgcccga ccccgcttat tgctctttgg cctactccta ctttttgtag gggtaggcct     9420

tttcctactc cccgctcggt agagcggcac acattagcta cactccatag ctaactgtcc     9480

cttttttttt tttttttttt tttttttttt tttttttttt tttttttttt ttcttttttt     9540

ctcttttcct tctttcttac cttattttac tttctttcct ggtggctcca tcttagccct     9600

agtcacggct agctgtgaaa ggtccgtgag ccgcatgact gcagagagtg ccgtaactgg     9660

tctctctgca gatcatgt                                                   9678


<210>  26
<211>  9678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  26
acccgcccct aataggggcg acactccgcc atgaatcact cccctgtgag gaactactgt       60

cttcacgcag aaagcgtcta gccatggcgt tagtatgagt gtcgtacagc ctccaggccc      120

ccccctcccg ggagagccat agtggtctgc ggaaccggtg agtacaccgg aattgccggg      180

aagactgggt cctttcttgg ataaacccac tctatgcccg gccatttggg cgtgcccccg      240

caagactgct agccgagtag cgttgggttg cgaaaggcct tgtggtactg cctgataggg      300

tgcttgcgag tgccccggga ggtctcgtag accgtgcacc atgagcacaa atcctaaacc      360

tcaaagaaaa accaaaagaa acaccaaccg tcgcccacaa gacgttaagt ttccgggcgg      420

cggccagatc gttggcggag tatacttgtt gccgcgcagg ggccccaggt tgggtgtgcg      480

cgcgacaagg aagacttcgg agcggtccca gccacgtgga aggcgccagc ccatccctaa      540

agatcggcgc tccactggca aatcctgggg aaaaccagga tacccctggc ccctatacgg      600

gaatgaggga ctcggctggg caggatggct cctgtccccc cgaggttccc gtccctcttg      660

gggccccaat gacccccggc ataggtcgcg caacgtgggt aaggtcatcg ataccctaac      720

gtgcggcttt gccgacctca tggggtacat ccctgtcgtg ggcgccccgc tcggcggcgt      780

cgccagagct ctcgcgcatg gcgtgagagt cctggaggac ggggttaatt ttgcaacagg      840

gaacttaccc ggttgctcct tttctatctt cttgctggcc ctgctgtcct gcatcaccac      900

cccggtctcc gctgccgaag tgaagaacat cagtaccggc tacatggtga ctaacgactg      960

caccaatgac agcattacct ggcagctcca ggctgctgtc ctccacgtcc ccgggtgcgt     1020

cccgtgcgag aaagtgggga atgcatctca gtgctggata ccggtctcac cgaatgtggc     1080

cgtgcagcgg cccggcgccc tcacgcaggg cttgcggacg cacatcgaca tggttgtgat     1140

gtccgccacg ctctgctctg ccctctacgt gggggacctc tgcggtgggg tgatgctcgc     1200

agcccaaatg ttcattgtct cgccgcagca ccactggttt gtccaagact gcaattgctc     1260

catctaccct ggtaccatca ctggacaccg catggcatgg gacatgatga tgaactggtc     1320

gcccacggct accatgatct tggcgtacgc gatgcgtgtc cccgaggtca ttatagacat     1380

cattagcggg gctcattggg gcgtcatgtt cggcttggcc tacttctcta tgcagggagc     1440

gtgggcgaaa gtcgttgtca tccttctgtt ggccgccggg gtggacgcgc gcacccatac     1500

tgttgggggt tctgccgcgc agaccaccgg gcgcctcacc agcttatttg acatgggccc     1560

caggcagaaa atccagctcg ttaacaccaa tggcagctgg cacatcaacc gcaccgccct     1620

gaactgcaat gactccttgc acaccggctt tatcgcgtct ctgttctaca cccacagctt     1680

caactcgtca ggatgtcccg aacgcatgtc cgcctgccgc agtatcgagg ccttccgggt     1740

gggatggggc gccttgcaat atgaggataa tgtcaccaat ccagaggata tgagacccta     1800

ttgctggcac tacccaccaa ggcagtgtgg cgtggtctcc gcgaagactg tgtgtggccc     1860

agtgtactgt ttcaccccca gcccagtggt agtgggcacg accgacaggc ttggagcgcc     1920

cacttacacg tggggggaga atgagacaga tgtcttccta ttgaacagca ctcgaccacc     1980

gctggggtca tggttcggct gcacgtggat gaactcttct ggctacacca agacttgcgg     2040

cgcaccaccc tgccgtacta gagctgactt caacgccagc acggacctgt tgtgccccac     2100

ggactgtttt aggaagcatc ctgataccac ttacctcaaa tgcggctctg ggccctggct     2160

cacgccaagg tgcctgatcg actaccccta caggctctgg cattacccct gcacagttaa     2220

ctataccatc ttcaaaataa ggatgtatgt gggaggggtt gagcacaggc tcacggctgc     2280

atgcaatttc actcgtgggg atcgttgcaa cttggaggac agagacagaa gtcaactgtc     2340

tcctttgttg cactccacca cggaatgggc cattttacct tgctcttact cggacctgcc     2400

cgccttgtcg actggtcttc tccacctcca ccaaaacatc gtggacgtac aattcatgta     2460

tggcctatca cctgccctca caaaatacat cgtccgatgg gagtgggtaa tactcttatt     2520

cctgctctta gcggacgcca gggtttgcgc ctgcttatgg atgctcatct tgttgggcca     2580

ggccgaagca gcactagaga agctggtcat cttgcacgct gcgagcgcag ctagctgcaa     2640

tggcttccta tattttgtca tctttttcgt ggctgcttgg tacatcaagg gtcgggtagt     2700

ccccttagct acctattccc tcactggcct gtggtccttt agcctactgc tcctagcatt     2760

gccccaacag gcttatgctt atgacgcatc tgtgcatggc cagataggag cggctctgct     2820

ggtaatgatc actctcttta ctctcacccc cgggtataag acccttctca gccggttttt     2880

gtggtggttg tgctatcttc tgaccctggg ggaagctatg gtccaggagt gggcaccacc     2940

tatgcaggtg cgcggtggcc gtgatggcat catatgggcc gtcgccatat tctacccagg     3000

tgtggtgttt gacataacca agtggctctt ggcggtgctt gggcctgctt acctcctaaa     3060

aggtgctttg acgcgcgtgc cgtacttcgt cagggctcac gctctactga ggatgtgcac     3120

catggcaagg catctcgcgg ggggcaggta cgtccagatg gcgctactag cccttggcag     3180

gtggactggc acttacatct atgaccacct cacccctatg tcggattggg ctgctagtgg     3240

cctgcgggac ctggcggtcg ccgttgagcc tatcatcttc agtccgatgg agaagaaagt     3300

cattgtctgg ggagcggaga cagctgcttg tggggacatt ttacacggac ttcccgtgtc     3360

cgcccgactt ggtcgggagg tcctccttgg cccagctgat ggctatacct ccaaggggtg     3420

gagtcttctc gcccccatca ctgcttacgc ccagcagaca cgtggccttt tgggcaccat     3480

agtggtgagc atgacggggc gcgacaagac agaacaggct ggggaaattc aggtcctgtc     3540

cacagtcact cagtccttcc tcggaacatc catctcgggg gttttgtgga ctgtctacca     3600

tggagctggc aacaagactc tggccggctc acggggtccg gtcacgcaga tgtactccag     3660

tgctgagggg gacttagtag ggtggcccag cccccctggg actaaatctt tggagccgtg     3720

cacgtgtgga gcggtcgacc tgtacctggt cacgcggaac gctgatgtca tcccggctcg     3780

aagacgcggg gacaaacggg gagcgctact ctccccgaga cctctttcca ccttgaaggg     3840

gtcctcagga ggcccggtgc tatgccccag gggccacgct gtcggagtct tccgggcagc     3900

tgtgtgctct cggggcgtgg ctaagtccat agatttcatc cccgttgaga cactcgacat     3960

cgtcacgcgg tcccccacct ttagtgacaa cagcacacca cctgctgtgc cccagaccta     4020

tcaggtcggg tacttgcatg ccccgactgg cagtggaaag agcaccaaag ttcctgtcgc     4080

atatgctgct caggggtata aagtgctagt gcttaatccc tcagtggctg ccaccctggg     4140

gtttggggcg tacttgtcta aggcacatgg catcaatccc aacattagga ctggagtcag     4200

gactgtgacg accggggcgc ccatcacgta ctccacatat ggcaaattcc tcgccgatgg     4260

gggctgtgcg ggcggcgcct acgacatcat catatgtgat gaatgccatg ccgtggactc     4320

taccaccatc cttggcatcg gaacagtcct tgatcaagca gagacagctg gggtcagact     4380

aactgtgctg gctacagcta cgccccctgg gtcagtgaca accccccacc ccaacataga     4440

ggaggtggcc cttgggcagg agggcgagat ccccttctat gggagggcga ttcccctgtc     4500

ttacatcaag ggaggaagac atctgatctt ctgccattca aagaaaaagt gtgacgagct     4560

cgcggcggcc cttcggggta tgggcttgaa ctcagtggca tactacagag ggttggacgt     4620

ctccgtaata ccaactcagg gagacgtagt ggtcgtcgcc accgacgccc tcatgacagg     4680

gtatactggg gactttgact ccgtgatcga ctgcaacgta gcggtcactc aagttgtaga     4740

cctcagttta gaccccacat tcaccataac cacacagatt gtccctcaag acgctgtctc     4800

acgtagccag cgccggggtc gcacgggtag gggaagactg ggcatttata ggtatgtttc     4860

cactggtgag cgagcctcag gaatgtttga cagtgtagtg ctctgtgagt gctacgacgc     4920

aggggccgca tggtatgagc tcacaccatc ggagaccacc gtcaggctca gggcgtattt     4980

caacacgccc ggtttgcctg tgtgccaaga ccatcttgag ttttgggagg cagttttcac     5040

cggcctcaca cacatagatg cccacttcct ttcccaaaca aagcaatcgg gggaaaattt     5100

cgcatactta acagcctacc aggctacagt gtgcgctagg gccaaagccc cccccccgtc     5160

ctgggacgtc atgtggaagt gtttgactcg actcaagccc acactcgtgg gccccacacc     5220

tctcctgtac cgcttgggct ctgttaccaa cgaggtcacc ctcacacatc ccgtgacgaa     5280

atacatcgcc acctgcatgc aagccgacct tgaggtcatg accagcacat gggtcttggc     5340

agggggagtc ttggcggccg tcgcctcgta ttgcctggcg accgggtgtg tttgcatcat     5400

cggccgcttg cacattaacc agcgagccgt cgttgcgccg gacaaggagg tcctctatga     5460

ggcttttgat gagatggagg aatgtgcctc tagggcggct ctcattgaag aggggcagcg     5520

gatagccgag atgctgaagt ccaagatcca aggcttattg cagcaagctt ccaaacaagc     5580

tcaagacata caacccactg tgcaggcttc atggcccaag gtagaacaat tctgggccaa     5640

acacatgtgg aacttcatta gcggcatcca atacctcgca ggactatcaa cactgccagg     5700

gaaccctgca gtagcttcca tgatggcgtt cagtgccgcc ctcaccagtc cgctgtcaac     5760

aagcaccact atccttctca acattttggg gggctggcta gcatcccaaa ttgcaccacc     5820

cgcgggggcc actggcttcg ttgtcagtgg cctagtggga gctgccgtag gcagtatagg     5880

cttaggtaag gtgctagtgg acatcctggc agggtatggt gcgggcattt cgggggctct     5940

cgtcgcattc aagatcatgt ctggcgagaa gccctccatg gaggatgtcg tcaacttgct     6000

gcctggaatt ctgtctccgg gtgccttggt agtgggagtc atctgcgcgg ccattctgcg     6060

ccgacacgtg ggaccggggg aaggcgccgt ccaatggatg aatagactca ttgcctttgc     6120

ttccagagga aatcacgtcg cccccaccca ctacgtgacg gagtcggatg cgtcgcagcg     6180

tgtgacccaa ctacttggct cccttaccat aaccagcctg ctcagaagac tccacaactg     6240

gattactgag gactgcccca tcccatgcgg cggctcgtgg ctccgcgatg tgtgggactg     6300

ggtttgcacc atcctaacag actttaaaaa ttggctgacc tccaaattat tcccaaagat     6360

gcccggcctc ccctttgtct cctgtcaaaa ggggtacaag ggcgtgtggg ccggcactgg     6420

catcatgacc acacggtgtc cttgcggcgc caatatctct ggcaatgtcc gcttgggctc     6480

catgagaatc acggggccta agacctgcat gaatatctgg caggggacct ttcctatcaa     6540

ttgttacacg gagggccagt gcgtgccgaa acccgcgcca aactttaagg tcgccatctg     6600

gagggtggcg gcctcagagt acgcggaggt gacgcagcac gggtcatacc actacataac     6660

aggactcacc actgataact tgaaagtccc ctgccaacta ccctctcccg agttcttttc     6720

ctgggtggac ggagtgcaga tccataggtt tgcccccaca ccgaagccgt ttttccggga     6780

tgaggtctcg ttctgcgttg ggcttaattc atttgtcgtc gggtcccagc ttccttgcga     6840

ccctgaaccc gacacagacg tattgatgtc catgctaaca gatccatctc atatcacggc     6900

ggagactgca gcgcggcgtt tagcgcgggg gtcaccccca tccgaggcaa gctcctcggc     6960

gagccagcta tcggcaccat cgctgcgagc cacctgcacc acccacggca aagcctatga     7020

tgtggacatg gtggatgcta acctgttcat ggggggcgat gtgactcgga tagagtctgg     7080

gtccaaagtg gtcgttctgg actctctcga cccaatggtc gaagaaagga gcgaccttga     7140

gccttcgata ccatcagaat acatgctccc caagaagagg ttcccaccag ctttaccggc     7200

ctgggcacgg cctgattaca acccaccgct tgtggaatcg tggaaaaggc cagattacca     7260

accggccact gttgcgggct gtgctctccc tcctcctagg aaaaccccga cgcctccccc     7320

aaggaggcgc cggacagtgg gcctaagtga ggactccata ggagatgccc ttcaacagct     7380

ggccattaag tcctttggcc agcccccccc aagcggcgat tcaggccttt ccacgggggc     7440

gggcgctgcc gattccggca gtcagacgcc tcctgatgag ttggcccttt cggagacagg     7500

ttccatctct tccatgcccc ccctcgaggg ggagcttgga gatccagacc tggagcctga     7560

gcaggtagag ccccaacccc ccccccaggg gggggtggca gctcccggct cggactcggg     7620

gtcctggtct acttgctccg aggaggacga ctccgtcgtg tgctgctcca tgtcatactc     7680

ctggaccggg gctctaataa ctccttgtag tcccgaagag gagaagttac cgattaaccc     7740

cttgagcaac tccctgttgc gatatcacaa caaggtgtac tgtaccacaa caaagagcgc     7800

ctcactaagg gctaaaaagg taacttttga taggatgcaa gtgctcgact cctactacga     7860

ctcagtctta aaggacatta agctagcggc ctccaaggtc accgcaaggc tcctcaccat     7920

ggaggaggct tgccagttaa ccccacccca ttctgcaaga tctaaatatg ggtttggggc     7980

taaggaggtc cgcagcttgt ccgggagggc cgttaaccac atcaagtccg tgtggaagga     8040

cctcctggag gactcagaaa caccaattcc cacaaccatt atggccaaaa atgaggtgtt     8100

ctgcgtggac cccaccaagg ggggcaagaa agcagctcgc cttatcgttt accctgacct     8160

cggcgtcagg gtctgcgaga agatggccct ttatgacatt acacaaaaac ttcctcaggc     8220

ggtgatgggg gcttcttatg gattccagta ttcccccgct cagcgggtag agtttctctt     8280

gaaagcatgg gcggaaaaga aggaccctat gggtttttcg tatgataccc gatgctttga     8340

ctcaaccgtc actgagagag acatcaggac tgaggagtcc atatatcggg cctgctcctt     8400

gcccgaggag gcccacactg ccatacactc gctaactgag agactttacg tgggagggcc     8460

tatgttcaac agcaagggcc aaacctgcgg gtacaggcgt tgccgcgcca gcggggtgct     8520

caccactagc atggggaaca ccatcacatg ctacgtgaaa gccttagcgg cttgtaaagc     8580

tgcagggata atcgcgccca caatgctggt atgcggcgat gacttggttg tcatctcaga     8640

aagccagggg accgaggagg acgagcggaa cctgagagcc ttcacggagg ctatgaccag     8700

gtattctgcc cctcctggtg acccccccag accggagtat gatctggagc tgataacatc     8760

ttgctcctca aatgtgtctg tggcgctggg cccacaaggc cgccgcagat actacctgac     8820

cagagaccct accactccaa tcgcccgggc tgcctgggaa acagttagac actcccctgt     8880

caattcatgg ctgggaaaca tcatccagta cgccccgacc atatgggctc gcatggtcct     8940

gatgacacac ttcttctcca ttctcatggc tcaagacacg ctggaccaga acctcaactt     9000

tgagatgtac ggagcggtgt actccgtgag tcccttggac ctcccagcta taattgaaag     9060

gttacatggg cttgacgctt tttctctgca cacatacact ccccacgaac tgacacgggt     9120

ggcttcagcc ctcagaaaac ttggggcgcc acccctcaga gcgtggaaga gccgggcacg     9180

tgcagtcagg gcgtccctca tctcccgtgg ggggagagcg gccgtttgcg gtcgatatct     9240

cttcaattgg gcggtgaaga ccaagctcaa actcactcca ttgccggaag cgcgcctcct     9300

ggatttatcc agctggttca ccgtcggcgc cggcgggggc ggcatttttc acagcgtgtc     9360

gcgtgcccga ccccgcttat tgctctttgg cctactccta ctttttgtag gggtaggcct     9420

tttcctactc cccgctcggt agagcggcac acattagcta cactccatag ctaactgtcc     9480

cttttttttt tttttttttt tttttttttt tttttttttt tttttttttt ttcttttttt     9540

ctcttttcct tctttcttac cttattttac tttctttcct ggtggctcca tcttagccct     9600

agtcacggct agctgtgaaa ggtccgtgag ccgcatgact gcagagagtg ccgtaactgg     9660

tctctctgca gatcatgt                                                   9678


<210>  27
<211>  9678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  27
acccgcccct aataggggcg acactccgcc atgaatcact cccctgtgag gaactactgt       60

cttcacgcag aaagcgtcta gccatggcgt tagtatgagt gtcgtacagc ctccaggccc      120

ccccctcccg ggagagccat agtggtctgc ggaaccggtg agtacaccgg aattgccggg      180

aagactgggt cctttcttgg ataaacccac tctatgcccg gccatttggg cgtgcccccg      240

caagactgct agccgagtag cgttgggttg cgaaaggcct tgtggtactg cctgataggg      300

tgcttgcgag tgccccggga ggtctcgtag accgtgcacc atgagcacaa atcctaaacc      360

tcaaagaaaa accaaaagaa acaccaaccg tcgcccacaa gacgttaagt ttccgggcgg      420

cggccagatc gttggcggag tatacttgtt gccgcgcagg ggccccaggt tgggtgtgcg      480

cgcgacaagg aagacttcgg agcggtccca gccacgtgga aggcgccagc ccatccctaa      540

agatcggcgc tccactggca aatcctgggg aaaaccagga tacccctggc ccctatacgg      600

gaatgaggga ctcggctggg caggatggct cctgtccccc cgaggttccc gtccctcttg      660

gggccccaat gacccccggc ataggtcgcg caacgtgggt aaggtcatcg ataccctaac      720

gtgcggcttt gccgacctca tggggtacat ccctgtcgtg ggcgccccgc tcggcggcgt      780

cgccagagct ctcgcgcatg gcgtgagagt cctggaggac ggggttaatt ttgcaacagg      840

gaacttaccc ggttgctcct tttctatctt cttgctggcc ctgctgtcct gcatcaccac      900

cccggtctcc gctgccgaag tgaagaacat cagtaccggc tacatggtga ctaacgactg      960

caccaatgac agcattacct ggcagctcca ggctgctgtc ctccacgtcc ccgggtgcgt     1020

cccgtgcgag aaagtgggga atgcatctca gtgctggata ccggtctcac cgaatgtggc     1080

cgtgcagcgg cccggcgccc tcacgcaggg cttgcggacg cacatcgaca tggttgtgat     1140

gtccgccacg ctctgctctg ccctctacgt gggggacctc tgcggtgggg tgatgctcgc     1200

agcccaaatg ttcattgtct cgccgcagca ccactggttt gtccaagact gcaattgctc     1260

catctaccct ggtaccatca ctggacaccg catggcatgg gacatgatga tgaactggtc     1320

gcccacggct accatgatct tggcgtacgc gatgcgtgtc cccgaggtca ttatagacat     1380

cattagcggg gctcattggg gcgtcatgtt cggcttggcc tacttctcta tgcagggagc     1440

gtgggcgaaa gtcgttgtca tccttctgtt ggccgccggg gtggacgcgc gcacccatac     1500

tgttgggggt tctgccgcgc agaccaccgg gcgcctcacc agcttatttg acatgggccc     1560

caggcagaaa atccagctcg ttaacaccaa tggcagctgg cacatcaacc gcaccgccct     1620

gaactgcaat gactccttgc acaccggctt tatcgcgtct ctgttctaca cccacagctt     1680

caactcgtca ggatgtcccg aacgcatgtc cgcctgccgc agtatcgagg ccttccgggt     1740

gggatggggc gccttgcaat atgaggataa tgtcaccaat ccagaggata tgagacccta     1800

ttgctggcac tacccaccaa ggcagtgtgg cgtggtctcc gcgaagactg tgtgtggccc     1860

agtgtactgt ttcaccccca gcccagtggt agtgggcacg accgacaggc ttggagcgcc     1920

cacttacacg tggggggaga atgagacaga tgtcttccta ttgaacagca ctcgaccacc     1980

gctggggtca tggttcggct gcacgtggat gaactcttct ggctacacca agacttgcgg     2040

cgcaccaccc tgccgtacta gagctgactt caacgccagc acggacctgt tgtgccccac     2100

ggactgtttt aggaagcatc ctgataccac ttacctcaaa tgcggctctg ggccctggct     2160

cacgccaagg tgcctgatcg actaccccta caggctctgg cattacccct gcacagttaa     2220

ctataccatc ttcaaaataa ggatgtatgt gggaggggtt gagcacaggc tcacggctgc     2280

atgcaatttc actcgtgggg atcgttgcaa cttggaggac agagacagaa gtcaactgtc     2340

tcctttgttg cactccacca cggaatgggc cattttacct tgctcttact cggacctgcc     2400

cgccttgtcg actggtcttc tccacctcca ccaaaacatc gtggacgtac aattcatgta     2460

tggcctatca cctgccctca caaaatacat cgtccgatgg gagtgggtaa tactcttatt     2520

cctgctctta gcggacgcca gggtttgcgc ctgcttatgg atgctcatct tgttgggcca     2580

ggccgaagca gcactagaga agctggtcat cttgcacgct gcgagcgcag ctagctgcaa     2640

tggcttccta tattttgtca tctttttcgt ggctgcttgg tacatcaagg gtcgggtagt     2700

ccccttagct acctattccc tcactggcct gtggtccttt agcctactgc tcctagcatt     2760

gccccaacag gcttatgctt atgacgcatc tgtgcatggc cagataggag cggctctgct     2820

ggtaatgatc actctcttta ctctcacccc cgggtataag acccttctca gccggttttt     2880

gtggtggttg tgctatcttc tgaccctggg ggaagctatg gtccaggagt gggcaccacc     2940

tatgcaggtg cgcggtggcc gtgatggcat catatgggcc gtcgccatat tctacccagg     3000

tgtggtgttt gacataacca agtggctctt ggcggtgctt gggcctgctt acctcctaaa     3060

aggtgctttg acgcgcgtgc cgtacttcgt cagggctcac gctctactga ggatgtgcac     3120

catggcaagg catctcgcgg ggggcaggta cgtccagatg gcgctactag cccttggcag     3180

gtggactggc acttacatct atgaccacct cacccctatg tcggattggg ctgctagtgg     3240

cctgcgggac ctggcggtcg ccgttgagcc tatcatcttc agtccgatgg agaagaaagt     3300

cattgtctgg ggagcggaga cagctgcttg tggggacatt ttacacggac ttcccgtgtc     3360

cgcccgactt ggtcgggagg tcctccttgg cccagctgat ggctatacct ccaaggggtg     3420

gagtcttctc gcccccatca ctgcttacgc ccagcagaca cgtggccttt tgggcaccat     3480

agtggtgagc atgacggggc gcgacaagac agaacaggct ggggaaattc aggtcctgtc     3540

cacagtcact cagtccttcc tcggaacatc catctcgggg gttttgtgga ctgtctacca     3600

tggagctggc aacaagactc tggccggctc acggggtccg gtcacgcaga tgtactccag     3660

tgctgagggg gacttagtag ggtggcccag cccccctggg actaaatctt tggagccgtg     3720

cacgtgtgga gcggtcgacc tgtacctggt cacgcggaac gctgatgtca tcccggctcg     3780

aagacgcggg gacaaacggg gagcgctact ctccccgaga cctctttcca ccttgaaggg     3840

gtcctcagga ggcccggtgc tatgccccag gggccacgct gtcggagtct tccgggcagc     3900

tgtgtgctct cggggcgtgg ctaagtccat agatttcatc cccgttgaga cactcgacat     3960

cgtcacgcgg tcccccacct ttagtgacaa cagcacacca cctgctgtgc cccagaccta     4020

tcaggtcggg tacttgcatg ccccgactgg cagtggaaag agcaccaaag ttcctgtcgc     4080

atatgctgct caggggtata aagtgctagt gcttaatccc tcagtggctg ccaccctggg     4140

gtttggggcg tacttgtcta aggcacatgg catcaatccc aacattagga ctggagtcag     4200

gactgtgacg accggggcgc ccatcacgta ctccacatat ggcaaattcc tcgccgatgg     4260

gggctgtgcg ggcggcgcct acgacatcat catatgtgat gaatgccatg ccgtggactc     4320

taccaccatc cttggcatcg gaacagtcct tgatcaagca gagacagctg gggtcagact     4380

aactgtgctg gctacagcta cgccccctgg gtcagtgaca accccccacc ccaacataga     4440

ggaggtggcc cttgggcagg agggcgagat ccccttctat gggagggcga ttcccctgtc     4500

ttacatcaag ggaggaagac atctgatctt ctgccattca aagaaaaagt gtgacgagct     4560

cgcggcggcc cttcggggta tgggcttgaa ctcagtggca tactacagag ggttggacgt     4620

ctccgtaata ccaactcagg gagacgtagt ggtcgtcgcc accgacgccc tcatgacagg     4680

gtatactggg gactttgact ccgtgatcga ctgcaacgta gcggtcactc aagttgtaga     4740

cctcagttta gaccccacat tcaccataac cacacagatt gtccctcaag acgctgtctc     4800

acgtagccag cgccggggtc gcacgggtag gggaagactg ggcatttata ggtatgtttc     4860

cactggtgag cgagcctcag gaatgtttga cagtgtagtg ctctgtgagt gctacgacgc     4920

aggggccgca tggtatgagc tcacaccatc ggagaccacc gtcaggctca gggcgtattt     4980

caacacgccc ggtttgcctg tgtgccaaga ccatcttgag ttttgggagg cagttttcac     5040

cggcctcaca cacatagatg cccacttcct ttcccaaaca aagcaatcgg gggaaaattt     5100

cgcatactta acagcctacc aggctacagt gtgcgctagg gccaaagccc cccccccgtc     5160

ctgggacgtc atgtggaagt gtttgactcg actcaagccc acactcgtgg gccccacacc     5220

tctcctgtac cgcttgggct ctgttaccaa cgaggtcacc ctcacacatc ccgtgacgaa     5280

atacatcgcc acctgcatgc aagccgacct tgaggtcatg accagcacat gggtcttggc     5340

agggggagtc ttggcggccg tcgcctcgta ttgcctggcg accgggtgtg tttgcatcat     5400

cggccgcttg cacattaacc agcgagccgt cgttgcgccg gacaaggagg tcctctatga     5460

ggcttttgat gagatggagg aatgtgcctc tagggcggct ctcattgaag aggggcagcg     5520

gatagccgag atgctgaagt ccaagatcca aggcttattg cagcaagctt ccaaacaagc     5580

tcaagacata caacccactg tgcaggcttc atggcccaag gtagaacaat tctgggccaa     5640

acacatgtgg aacttcatta gcggcatcca atacctcgca ggactatcaa cactgccagg     5700

gaaccctgca gtagcttcca tgatggcgtt cagtgccgcc ctcaccagtc cgctgtcaac     5760

aagcaccact atccttctca acattttggg gggctggcta gcatcccaaa ttgcaccacc     5820

cgcgggggcc actggcttcg ttgtcagtgg cctagtggga gctgccgtag gcagtatagg     5880

cttaggtaag gtgctagtgg acatcctggc agggtatggt gcgggcattt cgggggctct     5940

cgtcgcattc aagatcatgt ctggcgagaa gccctccatg gaggatgtcg tcaacttgct     6000

gcctggaatt ctgtctccgg gtgccttggt agtgggagtc atctgcgcgg ccattctgcg     6060

ccgacacgtg ggaccggggg aaggcgccgt ccaatggatg aatagactca ttgcctttgc     6120

ttccagagga aatcacgtcg cccccaccca ctacgtgacg gagtcggatg cgtcgcagcg     6180

tgtgacccaa ctacttggct cccttaccat aaccagcctg ctcagaagac tccacaactg     6240

gattactgag gactgcccca tcccatgcgg cggctcgtgg ctccgcgatg tgtgggactg     6300

ggtttgcacc atcctaacag actttaaaaa ttggctgacc tccaaattat tcccaaagat     6360

gcccggcctc ccctttgtct cctgtcaaaa ggggtacaag ggcgtgtggg ccggcactgg     6420

catcatgacc acacggtgtc cttgcggcgc caatatctct ggcaatgtcc gcttgggctc     6480

catgagaatc acggggccta agacctgcat gaatatctgg caggggacct ttcctatcaa     6540

ttgttacacg gagggccagt gcgtgccgaa acccgcgcca aactttaagg tcgccatctg     6600

gagggtggcg gcctcagagt acgcggaggt gacgcagcac gggtcatacc actacataac     6660

aggactcacc actgataact tgaaagtccc ctgccaacta ccctctcccg agttcttttc     6720

ctgggtggac ggagtgcaga tccataggtt tgcccccaca ccgaagccgt ttttccggga     6780

tgaggtctcg ttctgcgttg ggcttaattc atttgtcgtc gggtcccagc ttccttgcga     6840

ccctgaaccc gacacagacg tattgatgtc catgctaaca gatccatctc atatcacggc     6900

ggagactgca gcgcggcgtt tagcgcgggg gtcaccccca tccgaggcaa gctcctcggc     6960

gagccagcta tcggcaccat cgctgcgagc cacctgcacc acccacggca aagcctatga     7020

tgtggacatg gtggatgcta acctgttcat ggggggcgat gtgactcgga tagagtctgg     7080

gtccaaagtg gtcgttctgg actctctcga cccaatggtc gaagaaagga gcgaccttga     7140

gccttcgata ccatcagaat acatgctccc caagaagagg ttcccaccag ctttaccggc     7200

ctgggcacgg cctgattaca acccaccgct tgtggaatcg tggaaaaggc cagattacca     7260

accggccact gttgcgggct gtgctctccc tcctcctagg aaaaccccga cgcctccccc     7320

aaggaggcgc cggacagtgg gcctaagtga ggactccata ggagatgccc ttcaacagct     7380

ggccattaag tcctttggcc agcccccccc aagcggcgat tcaggccttt ccacgggggc     7440

gggcgctgcc gattccggca gtcagacgcc tcctgatgag ttggcccttt cggagacagg     7500

ttccatctct tccatgcccc ccctcgaggg ggagcttgga gatccagacc tggagcctga     7560

gcaggtagag ccccaacccc ccccccaggg gggggtggca gctcccggct cggactcggg     7620

gtcctggtct acttgctccg aggaggacga ctccgtcgtg tgctgctcca tgtcatactc     7680

ctggaccggg gctctaataa ctccttgtag tcccgaagag gagaagttac cgattaaccc     7740

cttgagcaac tccctgttgc gatatcacaa caaggtgtac tgtaccacaa caaagagcgc     7800

ctcactaagg gctaaaaagg taacttttga taggatgcaa gtgctcgact cctactacga     7860

ctcagtctta aaggacatta agctagcggc ctccaaggtc accgcaaggc tcctcaccat     7920

ggaggaggct tgccagttaa ccccacccca ttctgcaaga tctaaatatg ggtttggggc     7980

taaggaggtc cgcagcttgt ccgggagggc cgttaaccac atcaagtccg tgtggaagga     8040

cctcctggag gactcagaaa caccaattcc cacaaccatt atggccaaaa atgaggtgtt     8100

ctgcgtggac cccaccaagg ggggcaagaa agcagctcgc cttatcgttt accctgacct     8160

cggcgtcagg gtctgcgaga agatggccct ttatgacatt acacaaaaac ttcctcaggc     8220

ggtgatgggg gcttcttatg gattccagta ttcccccgct cagcgggtag agtttctctt     8280

gaaagcatgg gcggaaaaga aggaccctat gggtttttcg tatgataccc gatgctttga     8340

ctcaaccgtc actgagagag acatcaggac tgaggagtcc atatatcggg cctgctcctt     8400

gcccgaggag gcccacactg ccatacactc gctaactgag agactttacg tgggagggcc     8460

tatgttcaac agcaagggcc aaacctgcgg gtacaggcgt tgccgcgcca gcggggtgct     8520

caccactagc atggggaaca ccatcacatg ctacgtgaaa gccttagcgg cttgtaaagc     8580

tgcagggata atcgcgccca caatgctggt atgcggcgat gacttggttg tcatctcaga     8640

aagccagggg accgaggagg acgagcggaa cctgagagcc ttcacggagg ctatgaccag     8700

gtattctgcc cctcctggtg acccccccag accggagtat gatctggagc tgataacatc     8760

ttgctcctca aatgtgtctg tggcgctggg cccacaaggc cgccgcagat actacctgac     8820

cagagaccct accactccaa tcgcccgggc tgcctgggaa acagttagac actcccctgt     8880

caattcatgg ctgggaaaca tcatccagta cgccccgacc atatgggctc gcatggtcct     8940

gatgacacac ttcttctcca ttctcatggc tcaagacacg ctggaccaga acctcaactt     9000

tgagatgtac ggagcggtgt actccgtgag tcccttggac ctcccagcta taattgaaag     9060

gttacatggg cttgacgctt tttctctgca cacatacact ccccacgaac tgacacgggt     9120

ggcttcagcc ctcagaaaac ttggggcgcc acccctcaga gcgtggaaga gccgggcacg     9180

tgcagtcagg gcgtccctca tctcccgtgg ggggagagcg gccgtttgcg gtcgatatct     9240

cttcaattgg gcggtgaaga ccaagctcaa actcactcca ttgccggaag cgcgcctcct     9300

ggatttatcc agctggttca ccgtcggcgc cggcgggggc ggcatttatc acagcgtgtc     9360

gcgtgcccga ccccgcttat tgctctttgg cctactccta ctttttgtag gggtaggcct     9420

tttcctactc cccgctcggt agagcggcac acattaggta cactccatag ctaactgtcc     9480

cttttttttt tttttttttt tttttttttt tttttttttt tttttttttt ttcttttttt     9540

ctcttttcct tctttcttac cttattttac tttctttcct ggtggctcca tcttagccct     9600

agtcacggct agctgtgaaa ggtccgtgag ccgcatgact gcagagagtg ccgtaactgg     9660

tctctctgca gatcatgt                                                   9678


<210>  28
<211>  9678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  28
acccgcccct aataggggcg acactccgcc atgaatcact cccctgtgag gaactactgt       60

cttcacgcag aaagcgtcta gccatggcgt tagtatgagt gtcgtacagc ctccaggccc      120

ccccctcccg ggagagccat agtggtctgc ggaaccggtg agtacaccgg aattgccggg      180

aagactgggt cctttcttgg ataaacccac tctatgcccg gccatttggg cgtgcccccg      240

caagactgct agccgagtag cgttgggttg cgaaaggcct tgtggtactg cctgataggg      300

tgcttgcgag tgccccggga ggtctcgtag accgtgcacc atgagcacaa atcctaaacc      360

tcaaagaaaa accaaaagaa acaccaaccg tcgcccacaa gacgttaagt ttccgggcgg      420

cggccagatc gttggcggag tatacttgtt gccgcgcagg ggccccaggt tgggtgtgcg      480

cgcgacaagg aagacttcgg agcggtccca gccacgtgga aggcgccagc ccatccctaa      540

agatcggcgc tccactggca aatcctgggg aaaaccagga tacccctggc ccctatacgg      600

gaatgaggga ctcggctggg caggatggct cctgtccccc cgaggttccc gtccctcttg      660

gggccccaat gacccccggc ataggtcgcg caacgtgggt aaggtcatcg ataccctaac      720

gtgcggcttt gccgacctca tggggtacat ccctgtcgtg ggcgccccgc tcggcggcgt      780

cgccagagct ctcgcgcatg gcgtgagagt cctggaggac ggggttaatt ttgcaacagg      840

gaacttaccc ggttgctcct tttctatctt cttgctggcc ctgctgtcct gcatcaccac      900

cccggtctcc gctgccgaag tgaagaacat cagtaccggc tacatggtga ctaacgactg      960

caccaatgac agcattacct ggcagctcca ggctgctgtc ctccacgtcc ccgggtgcgt     1020

cccgtgcgag aaagtgggga atgcatctca gtgctggata ccggtctcac cgaatgtggc     1080

cgtgcagcgg cccggcgccc tcacgcaggg cttgcggacg cacatcgaca tggttgtgat     1140

gtccgccacg ctctgctctg ccctctacgt gggggacctc tgcggtgggg tgatgctcgc     1200

agcccaaatg ttcattgtct cgccgcagca ccactggttt gtccaagact gcaattgctc     1260

catctaccct ggtaccatca ctggacaccg catggcatgg gacatgatga tgaactggtc     1320

gcccacggct accatgatct tggcgtacgc gatgcgtgtc cccgaggtca ttatagacat     1380

cattagcggg gctcattggg gcgtcatgtt cggcttggcc tacttctcta tgcagggagc     1440

gtgggcgaaa gtcgttgtca tccttctgtt ggccgccggg gtggacgcgc gcacccatac     1500

tgttgggggt tctgccgcgc agaccaccgg gcgcctcacc agcttatttg acatgggccc     1560

caggcagaaa atccagctcg ttaacaccaa tggcagctgg cacatcaacc gcaccgccct     1620

gaactgcaat gactccttgc acaccggctt tatcgcgtct ctgttctaca cccacagctt     1680

caactcgtca ggatgtcccg aacgcatgtc cgcctgccgc agtatcgagg ccttccgggt     1740

gggatggggc gccttgcaat atgaggataa tgtcaccaat ccagaggata tgagacccta     1800

ttgctggcac tacccaccaa ggcagtgtgg cgtggtctcc gcgaagactg tgtgtggccc     1860

agtgtactgt ttcaccccca gcccagtggt agtgggcacg accgacaggc ttggagcgcc     1920

cacttacacg tggggggaga atgagacaga tgtcttccta ttgaacagca ctcgaccacc     1980

gctggggtca tggttcggct gcacgtggat gaactcttct ggctacacca agacttgcgg     2040

cgcaccaccc tgccgtacta gagctgactt caacgccagc acggacctgt tgtgccccac     2100

ggactgtttt aggaagcatc ctgataccac ttacctcaaa tgcggctctg ggccctggct     2160

cacgccaagg tgcctgatcg actaccccta caggctctgg cattacccct gcacagttaa     2220

ctataccatc ttcaaaataa ggatgtatgt gggaggggtt gagcacaggc tcacggctgc     2280

atgcaatttc actcgtgggg atcgttgcaa cttggaggac agagacagaa gtcaactgtc     2340

tcctttgttg cactccacca cggaatgggc cattttacct tgctcttact cggacctgcc     2400

cgccttgtcg actggtcttc tccacctcca ccaaaacatc gtggacgtac aattcatgta     2460

tggcctatca cctgccctca caaaatacat cgtccgatgg gagtgggtaa tactcttatt     2520

cctgctctta gcggacgcca gggtttgcgc ctgcttatgg atgctcatct tgttgggcca     2580

ggccgaagca gcactagaga agctggtcat cttgcacgct gcgagcgcag ctagctgcaa     2640

tggcttccta tattttgtca tctttttcgt ggctgcttgg tacatcaagg gtcgggtagt     2700

ccccttagct acctattccc tcactggcct gtggtccttt agcctactgc tcctagcatt     2760

gccccaacag gcttatgctt atgacgcatc tgtgcatggc cagataggag cggctctgct     2820

ggtaatgatc actctcttta ctctcacccc cgggtataag acccttctca gccggttttt     2880

gtggtggttg tgctatcttc tgaccctggg ggaagctatg gtccaggagt gggcaccacc     2940

tatgcaggtg cgcggtggcc gtgatggcat catatgggcc gtcgccatat tctacccagg     3000

tgtggtgttt gacataacca agtggctctt ggcggtgctt gggcctgctt acctcctaaa     3060

aggtgctttg acgcgcgtgc cgtacttcgt cagggctcac gctctactga ggatgtgcac     3120

catggcaagg catctcgcgg ggggcaggta cgtccagatg gcgctactag cccttggcag     3180

gtggactggc acttacatct atgaccacct cacccctatg tcggattggg ctgctagtgg     3240

cctgcgggac ctggcggtcg ccgttgagcc tatcatcttc agtccgatgg agaagaaagt     3300

cattgtctgg ggagcggaga cagctgcttg tggggacatt ttacacggac ttcccgtgtc     3360

cgcccgactt ggtcgggagg tcctccttgg cccagctgat ggctatacct ccaaggggtg     3420

gagtcttctc gcccccatca ctgcttacgc ccagcagaca cgtggccttt tgggcaccat     3480

agtggtgagc atgacggggc gcgacaagac agaacaggct ggggaaattc aggtcctgtc     3540

cacagtcact cagtccttcc tcggaacatc catctcgggg gttttgtgga ctgtctacca     3600

tggagctggc aacaagactc tggccggctc acggggtccg gtcacgcaga tgtactccag     3660

tgctgagggg gacttagtag ggtggcccag cccccctggg actaaatctt tggagccgtg     3720

cacgtgtgga gcggtcgacc tgtacctggt cacgcggaac gctgatgtca tcccggctcg     3780

aagacgcggg gacaaacggg gagcgctact ctccccgaga cctctttcca ccttgaaggg     3840

gtcctcagga ggcccggtgc tatgccccag gggccacgct gtcggagtct tccgggcagc     3900

tgtgtgctct cggggcgtgg ctaagtccat agatttcatc cccgttgaga cactcgacat     3960

cgtcacgcgg tcccccacct ttagtgacaa cagcacacca cctgctgtgc cccagaccta     4020

tcaggtcggg tacttgcatg ccccgactgg cagtggaaag agcaccaaag ttcctgtcgc     4080

atatgctgct caggggtata aagtgctagt gcttaatccc tcagtggctg ccaccctggg     4140

gtttggggcg tacttgtcta aggcacatgg catcaatccc aacattagga ctggagtcag     4200

gactgtgacg accggggcgc ccatcacgta ctccacatat ggcaaattcc tcgccgatgg     4260

gggctgtgcg ggcggcgcct acgacatcat catatgtgat gaatgccatg ccgtggactc     4320

taccaccatc cttggcatcg gaacagtcct tgatcaagca gagacagctg gggtcagact     4380

aactgtgctg gctacagcta cgccccctgg gtcagtgaca accccccacc ccaacataga     4440

ggaggtggcc cttgggcagg agggcgagat ccccttctat gggagggcga ttcccctgtc     4500

ttacatcaag ggaggaagac atctgatctt ctgccattca aagaaaaagt gtgacgagct     4560

cgcggcggcc cttcggggta tgggcttgaa ctcagtggca tactacagag ggttggacgt     4620

ctccgtaata ccaactcagg gagacgtagt ggtcgtcgcc accgacgccc tcatgacagg     4680

gtatactggg gactttgact ccgtgatcga ctgcaacgta gcggtcactc aagttgtaga     4740

cctcagttta gaccccacat tcaccataac cacacagatt gtccctcaag acgctgtctc     4800

acgtagccag cgccggggtc gcacgggtag gggaagactg ggcatttata ggtatgtttc     4860

cactggtgag cgagcctcag gaatgtttga cagtgtagtg ctctgtgagt gctacgacgc     4920

aggggccgca tggtatgagc tcacaccatc ggagaccacc gtcaggctca gggcgtattt     4980

caacacgccc ggtttgcctg tgtgccaaga ccatcttgag ttttgggagg cagttttcac     5040

cggcctcaca cacatagatg cccacttcct ttcccaaaca aagcaatcgg gggaaaattt     5100

cgcatactta acagcctacc aggctacagt gtgcgctagg gccaaagccc cccccccgtc     5160

ctgggacgtc atgtggaagt gtttgactcg actcaagccc acactcgtgg gccccacacc     5220

tctcctgtac cgcttgggct ctgttaccaa cgaggtcacc ctcacacatc ccgtgacgaa     5280

atacatcgcc acctgcatgc aagccgacct tgaggtcatg accagcacat gggtcttggc     5340

agggggagtc ttggcggccg tcgcctcgta ttgcctggcg accgggtgtg tttgcatcat     5400

cggccgcttg cacattaacc agcgagccgt cgttgcgccg gacaaggagg tcctctatga     5460

ggcttttgat gagatggagg aatgtgcctc tagggcggct ctcattgaag aggggcagcg     5520

gatagccgag atgctgaagt ccaagatcca aggcttattg cagcaagctt ccaaacaagc     5580

tcaagacata caacccactg tgcaggcttc atggcccaag gtagaacaat tctgggccaa     5640

acacatgtgg aacttcatta gcggcatcca atacctcgca ggactatcaa cactgccagg     5700

gaaccctgca gtagcttcca tgatggcgtt cagtgccgcc ctcaccagtc cgctgtcaac     5760

aagcaccact atccttctca acattttggg gggctggcta gcatcccaaa ttgcaccacc     5820

cgcgggggcc actggcttcg ttgtcagtgg cctagtggga gctgccgtag gcagtatagg     5880

cttaggtaag gtgctagtgg acatcctggc agggtatggt gcgggcattt cgggggctct     5940

cgtcgcattc aagatcatgt ctggcgagaa gccctccatg gaggatgtcg tcaacttgct     6000

gcctggaatt ctgtctccgg gtgccttggt agtgggagtc atctgcgcgg ccattctgcg     6060

ccgacacgtg ggaccggggg aaggcgccgt ccaatggatg aatagactca ttgcctttgc     6120

ttccagagga aatcacgtcg cccccaccca ctacgtgacg gagtcggatg cgtcgcagcg     6180

tgtgacccaa ctacttggct cccttaccat aaccagcctg ctcagaagac tccacaactg     6240

gattactgag gactgcccca tcccatgcgg cggctcgtgg ctccgcgatg tgtgggactg     6300

ggtttgcacc atcctaacag actttaaaaa ttggctgacc tccaaattat tcccaaagat     6360

gcccggcctc ccctttgtct cctgtcaaaa ggggtacaag ggcgtgtggg ccggcactgg     6420

catcatgacc acacggtgtc cttgcggcgc caatatctct ggcaatgtcc gcttgggctc     6480

catgagaatc acggggccta agacctgcat gaatatctgg caggggacct ttcctatcaa     6540

ttgttacacg gagggccagt gcgtgccgaa acccgcgcca aactttaagg tcgccatctg     6600

gagggtggcg gcctcagagt acgcggaggt gacgcagcac gggtcatacc actacataac     6660

aggactcacc actgataact tgaaagtccc ctgccaacta ccctctcccg agttcttttc     6720

ctgggtggac ggagtgcaga tccataggtt tgcccccaca ccgaagccgt ttttccggga     6780

tgaggtctcg ttctgcgttg ggcttaattc atttgtcgtc gggtcccagc ttccttgcga     6840

ccctgaaccc gacacagacg tattgatgtc catgctaaca gatccatctc atatcacggc     6900

ggagactgca gcgcggcgtt tagcgcgggg gtcaccccca tccgaggcaa gctcctcggc     6960

gagccagcta tcggcaccat cgctgcgagc cacctgcacc acccacggca aagcctatga     7020

tgtggacatg gtggatgcta acctgttcat ggggggcgat gtgactcgga tagagtctgg     7080

gtccaaagtg gtcgttctgg actctctcga cccaatggtc gaagaaagga gcgaccttga     7140

gccttcgata ccatcagaat acatgctccc caagaagagg ttcccaccag ctttaccggc     7200

ctgggcacgg cctgattaca acccaccgct tgtggaatcg tggaaaaggc cagattacca     7260

accggccact gttgcgggct gtgctctccc tcctcctagg aaaaccccga cgcctccccc     7320

aaggaggcgc cggacagtgg gcctaagtga ggactccata ggagatgccc ttcaacagct     7380

ggccattaag tcctttggcc agcccccccc aagcggcgat tcaggccttt ccacgggggc     7440

gggcgctgcc gattccggca gtcagacgcc tcctgatgag ttggcccttt cggagacagg     7500

ttccatctct tccatgcccc ccctcgaggg ggagcttgga gatccagacc tggagcctga     7560

gcaggtagag ccccaacccc ccccccaggg gggggtggca gctcccggct cggactcggg     7620

gtcctggtct acttgctccg aggaggacga ctccgtcgtg tgctgctcca tgtcatactc     7680

ctggaccggg gctctaataa ctccttgtag tcccgaagag gagaagttac cgattaaccc     7740

cttgagcaac tccctgttgc gatatcacaa caaggtgtac tgtaccacaa caaagagcgc     7800

ctcactaagg gctaaaaagg taacttttga taggatgcaa gtgctcgact cctactacga     7860

ctcagtctta aaggacatta agctagcggc ctccaaggtc accgcaaggc tcctcaccat     7920

ggaggaggct tgccagttaa ccccacccca ttctgcaaga tctaaatatg ggtttggggc     7980

taaggaggtc cgcagcttgt ccgggagggc cgttaaccac atcaagtccg tgtggaagga     8040

cctcctggag gactcagaaa caccaattcc cacaaccatt atggccaaaa atgaggtgtt     8100

ctgcgtggac cccaccaagg ggggcaagaa agcagctcgc cttatcgttt accctgacct     8160

cggcgtcagg gtctgcgaga agatggccct ttatgacatt acacaaaaac ttcctcaggc     8220

ggtgatgggg gcttcttatg gattccagta ttcccccgct cagcgggtag agtttctctt     8280

gaaagcatgg gcggaaaaga aggaccctat gggtttttcg tatgataccc gatgctttga     8340

ctcaaccgtc actgagagag acatcaggac tgaggagtcc atatatcggg cctgctcctt     8400

gcccgaggag gcccacactg ccatacactc gctaactgag agactttacg tgggagggcc     8460

tatgttcaac agcaagggcc aaacctgcgg gtacaggcgt tgccgcgcca gcggggtgct     8520

caccactagc atggggaaca ccatcacatg ctacgtgaaa gccttagcgg cttgtaaagc     8580

tgcagggata atcgcgccca caatgctggt atgcggcgat gacttggttg tcatctcaga     8640

aagccagggg accgaggagg acgagcggaa cctgagagcc ttcacggagg ctatgaccag     8700

gtattctgcc cctcctggtg acccccccag accggagtat gatctggagc tgataacatc     8760

ttgctcctca aatgtgtctg tggcgctggg cccacaaggc cgccgcagat actacctgac     8820

cagagaccct accactccaa tcgcccgggc tgcctgggaa acagttagac actcccctgt     8880

caattcatgg ctgggaaaca tcatccagta cgccccgacc atatgggctc gcatggtcct     8940

gatgacacac ttcttctcca ttctcatggc tcaagacacg ctggaccaga acctcaactt     9000

tgagatgtac ggagcggtgt actccgtgag tcccttggac ctcccagcta taattgaaag     9060

gttacatggg cttgacgctt tttctctgca cacatacact ccccacgaac tgacacgggt     9120

ggcttcagcc ctcagaaaac ttggggcgcc acccctcaga gcgtggaaga gccgggcacg     9180

tgcagtcagg gcgtccctca tctcccgtgg ggggagagcg gccgtttgcg gtcgatatct     9240

cttcaattgg gcggtgaaga ccaagctcaa actcactcca ttgccggaag cgcgcctcct     9300

ggatttatcc agctggttca ccgtcggcgc cggcgggggc ggcatttttc acagcgtgtc     9360

gcgtgcccga ccccgcttat tgctctttgg cctactccta ctttttgtag gggtaggcct     9420

tttcctactc cccgctcggt agagcggcac acattaggta cactccatag ctaactgtcc     9480

cttttttttt tttttttttt tttttttttt tttttttttt tttttttttt ttcttttttt     9540

ctcttttcct tctttcttac cttattttac tttctttcct ggtggctcca tcttagccct     9600

agtcacggct agctgtgaaa ggtccgtgag ccgcatgact gcagagagtg ccgtaactgg     9660

tctctctgca gatcatgt                                                   9678


<210>  29
<211>  9678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  29
acccgcccct aataggggcg acactccgcc atgaatcact cccctgtgag gaactactgt       60

cttcacgcag aaagcgtcta gccatggcgt tagtatgagt gtcgtacagc ctccaggccc      120

ccccctcccg ggagagccat agtggtctgc ggaaccggtg agtacaccgg aattgccggg      180

aagactgggt cctttcttgg ataaacccac tctatgcccg gccatttggg cgtgcccccg      240

caagactgct agccgagtag cgttgggttg cgaaaggcct tgtggtactg cctgataggg      300

tgcttgcgag tgccccggga ggtctcgtag accgtgcacc atgagcacaa atcctaaacc      360

tcaaagaaaa accaaaagaa acaccaaccg tcgcccacaa gacgttaagt ttccgggcgg      420

cggccagatc gttggcggag tatacttgtt gccgcgcagg ggccccaggt tgggtgtgcg      480

cgcgacaagg aagacttcgg agcggtccca gccacgtgga aggcgccagc ccatccctaa      540

agatcggcgc tccactggca aatcctgggg aaaaccagga tacccctggc ccctatacgg      600

gaatgaggga ctcggctggg caggatggct cctgtccccc cgaggttccc gtccctcttg      660

gggccccaat gacccccggc ataggtcgcg caacgtgggt aaggtcatcg ataccctaac      720

gtgcggcttt gccgacctca tggggtacat ccctgtcgtg ggcgccccgc tcggcggcgt      780

cgccagagct ctcgcgcatg gcgtgagagt cctggaggac ggggttaatt ttgcaacagg      840

gaacttaccc ggttgctcct tttctatctt cttgctggcc ctgctgtcct gcatcaccac      900

cccggtctcc gctgccgaag tgaagaacat cagtaccggc tacatggtga ctaacgactg      960

caccaatgac agcattacct ggcagctcca ggctgctgtc ctccacgtcc ccgggtgcgt     1020

cccgtgcgag aaagtgggga atgcatctca gtgctggata ccggtctcac cgaatgtggc     1080

cgtgcagcgg cccggcgccc tcacgcaggg cttgcggacg cacatcgaca tggttgtgat     1140

gtccgccacg ctctgctctg ccctctacgt gggggacctc tgcggtgggg tgatgctcgc     1200

agcccaaatg ttcattgtct cgccgcagca ccactggttt gtccaagact gcaattgctc     1260

catctaccct ggtaccatca ctggacaccg catggcatgg gacatgatga tgaactggtc     1320

gcccacggct accatgatct tggcgtacgc gatgcgtgtc cccgaggtca ttatagacat     1380

cattagcggg gctcattggg gcgtcatgtt cggcttggcc tacttctcta tgcagggagc     1440

gtgggcgaaa gtcgttgtca tccttctgtt ggccgccggg gtggacgcgc gcacccatac     1500

tgttgggggt tctgccgcgc agaccaccgg gcgcctcacc agcttatttg acatgggccc     1560

caggcagaaa atccagctcg ttaacaccaa tggcagctgg cacatcaacc gcaccgccct     1620

gaactgcaat gactccttgc acaccggctt tatcgcgtct ctgttctaca cccacagctt     1680

caactcgtca ggatgtcccg aacgcatgtc cgcctgccgc agtatcgagg ccttccgggt     1740

gggatggggc gccttgcaat atgaggataa tgtcaccaat ccagaggata tgagacccta     1800

ttgctggcac tacccaccaa ggcagtgtgg cgtggtctcc gcgaagactg tgtgtggccc     1860

agtgtactgt ttcaccccca gcccagtggt agtgggcacg accgacaggc ttggagcgcc     1920

cacttacacg tggggggaga atgagacaga tgtcttccta ttgaacagca ctcgaccacc     1980

gctggggtca tggttcggct gcacgtggat gaactcttct ggctacacca agacttgcgg     2040

cgcaccaccc tgccgtacta gagctgactt caacgccagc acggacctgt tgtgccccac     2100

ggactgtttt aggaagcatc ctgataccac ttacctcaaa tgcggctctg ggccctggct     2160

cacgccaagg tgcctgatcg actaccccta caggctctgg cattacccct gcacagttaa     2220

ctataccatc ttcaaaataa ggatgtatgt gggaggggtt gagcacaggc tcacggctgc     2280

atgcaatttc actcgtgggg atcgttgcaa cttggaggac agagacagaa gtcaactgtc     2340

tcctttgttg cactccacca cggaatgggc cattttacct tgctcttact cggacctgcc     2400

cgccttgtcg actggtcttc tccacctcca ccaaaacatc gtggacgtac aattcatgta     2460

tggcctatca cctgccctca caaaatacat cgtccgatgg gagtgggtaa tactcttatt     2520

cctgctctta gcggacgcca gggtttgcgc ctgcttatgg atgctcatct tgttgggcca     2580

ggccgaagca gcactagaga agctggtcat cttgcacgct gcgagcgcag ctagctgcaa     2640

tggcttccta tattttgtca tcttttccgt ggctgcttgg tacatcaagg gtcgggtagt     2700

ccccttagct acctattccc tcactggcct gtggtccttt agcctactgc tcctagcatt     2760

gccccaacag gcttatgctt atgacgcatc tgtgcatggc cagataggag cggctctgct     2820

ggtaatgatc actctcttta ctctcacccc cgggtataag acccttctca gccggttttt     2880

gtggtggttg tgctatcttc tgaccctggg ggaagctatg gtccaggagt gggcaccacc     2940

tatgcaggtg cgcggtggcc gtgatggcat catatgggcc gtcgccatat tctacccagg     3000

tgtggtgttt gacataacca agtggctctt ggcggtgctt gggcctgctt acctcctaaa     3060

aggtgctttg acgcgcgtgc cgtacttcgt cagggctcac gctctactga ggatgtgcac     3120

catggcaagg catctcgcgg ggggcaggta cgtccagatg gcgctactag cccttggcag     3180

gtggactggc acttacatct atgaccacct cacccctatg tcggattggg ctgctagtgg     3240

cctgcgggac ctggcggtcg ccgttgagcc tatcatcttc agtccgatgg agaagaaagt     3300

cattgtctgg ggagcggaga cagctgcttg tggggacatt ttacacggac ttcccgtgtc     3360

cgcccgactt ggtcgggagg tcctccttgg cccagctgat ggctatacct ccaaggggtg     3420

gagtcttctc gcccccatca ctgcttacgc ccagcagaca cgtggccttt tgggcaccat     3480

agtggtgagc atgacggggc gcgacaagac agaacaggct ggggaaattc aggtcctgtc     3540

cacagtcact cagtccttcc tcggaacatc catctcgggg gttttgtgga ctgtctacca     3600

tggagctggc aacaagactc tggccggctc acggggtccg gtcacgcaga tgtactccag     3660

tgctgagggg gacttagtag ggtggcccag cccccctggg actaaatctt tggagccgtg     3720

cacgtgtgga gcggtcgacc tgtacctggt cacgcggaac gctgatgtca tcccggctcg     3780

aagacgcggg gacaaacggg gagcgctact ctccccgaga cctctttcca ccttgaaggg     3840

gtcctcagga ggcccggtgc tatgccccag gggccacgct gtcggagtct tccgggcagc     3900

tgtgtgctct cggggcgtgg ctaagtccat agatttcatc cccgttgaga cactcgacat     3960

cgtcacgcgg tcccccacct ttagtgacaa cagcacacca cctgctgtgc cccagaccta     4020

tcaggtcggg tacttgcatg ccccgactgg cagtggaaag agcaccaaag ttcctgtcgc     4080

atatgctgct caggggtata aagtgctagt gcttaatccc tcagtggctg ccaccctggg     4140

gtttggggcg tacttgtcta aggcacatgg catcaatccc aacattagga ctggagtcag     4200

gactgtgacg accggggcgc ccatcacgta ctccacatat ggcaaattcc tcgccgatgg     4260

gggctgtgcg ggcggcgcct acgacatcat catatgtgat gaatgccatg ccgtggactc     4320

taccaccatc cttggcatcg gaacagtcct tgatcaagca gagacagctg gggtcagact     4380

aactgtgctg gctacagcta cgccccctgg gtcagtgaca accccccacc ccaacataga     4440

ggaggtggcc cttgggcagg agggcgagat ccccttctat gggagggcga ttcccctgtc     4500

ttacatcaag ggaggaagac atctgatctt ctgccattca aagaaaaagt gtgacgagct     4560

cgcggcggcc cttcggggta tgggcttgaa ctcagtggca tactacagag ggttggacgt     4620

ctccgtaata ccaactcagg gagacgtagt ggtcgtcgcc accgacgccc tcatgacagg     4680

gtatactggg gactttgact ccgtgatcga ctgcaacgta gcggtcactc aagttgtaga     4740

cctcagttta gaccccacat tcaccataac cacacagatt gtccctcaag acgctgtctc     4800

acgtagccag cgccggggtc gcacgggtag gggaagactg ggcatttata ggtatgtttc     4860

cactggtgag cgagcctcag gaatgtttga cagtgtagtg ctctgtgagt gctacgacgc     4920

aggggccgca tggtatgagc tcacaccatc ggagaccacc gtcaggctca gggcgtattt     4980

caacacgccc ggtttgcctg tgtgccaaga ccatcttgag ttttgggagg cagttttcac     5040

cggcctcaca cacatagatg cccacttcct ttcccaaaca aagcaatcgg gggaaaattt     5100

cgcatactta acagcctacc aggctacagt gtgcgctagg gccaaagccc cccccccgtc     5160

ctgggacgtc atgtggaagt gtttgactcg actcaagccc acactcgtgg gccccacacc     5220

tctcctgtac cgcttgggct ctgttaccaa cgaggtcacc ctcacacatc ccgtgacgaa     5280

atacatcgcc acctgcatgc aagccgacct tgaggtcatg accagcacat gggtcttggc     5340

agggggagtc ttggcggccg tcgcctcgta ttgcctggcg accgggtgtg tttgcatcat     5400

cggccgcttg cacattaacc agcgagccgt cgttgcgccg gacaaggagg tcctctatga     5460

ggcttttgat gagatggagg aatgtgcctc tagggcggct ctcattgaag aggggcagcg     5520

gatagccgag atgctgaagt ccaagatcca aggcttattg cagcaagctt ccaaacaagc     5580

tcaagacata caacccactg tgcaggcttc atggcccaag gtagaacaat tctgggccaa     5640

acacatgtgg aacttcatta gcggcatcca atacctcgca ggactatcaa cactgccagg     5700

gaaccctgca gtagcttcca tgatggcgtt cagtgccgcc ctcaccagtc cgctgtcaac     5760

aagcaccact atccttctca acattttggg gggctggcta gcatcccaaa ttgcaccacc     5820

cgcgggggcc actggcttcg ttgtcagtgg cctagtggga gctgccgtag gcagtatagg     5880

cttaggtaag gtgctagtgg acatcctggc agggtatggt gcgggcattt cgggggctct     5940

cgtcgcattc aagatcatgt ctggcgagaa gccctccatg gaggatgtcg tcaacttgct     6000

gcctggaatt ctgtctccgg gtgccttggt agtgggagtc atctgcgcgg ccattctgcg     6060

ccgacacgtg ggaccggggg aaggcgccgt ccaatggatg aatagactca ttgcctttgc     6120

ttccagagga aatcacgtcg cccccaccca ctacgtgacg gagtcggatg cgtcgcagcg     6180

tgtgacccaa ctacttggct cccttaccat aaccagcctg ctcagaagac tccacaactg     6240

gattactgag gactgcccca tcccatgcgg cggctcgtgg ctccgcgatg tgtgggactg     6300

ggtttgcacc atcctaacag actttaaaaa ttggctgacc tccaaattat tcccaaagat     6360

gcccggcctc ccctttgtct cctgtcaaaa ggggtacaag ggcgtgtggg ccggcactgg     6420

catcatgacc acacggtgtc cttgcggcgc caatatctct ggcaatgtcc gcttgggctc     6480

catgagaatc acggggccta agacctgcat gaatatctgg caggggacct ttcctatcaa     6540

ttgttacacg gagggccagt gcgtgccgaa acccgcgcca aactttaagg tcgccatctg     6600

gagggtggcg gcctcagagt acgcggaggt gacgcagcac gggtcatacc actacataac     6660

aggactcacc actgataact tgaaagtccc ctgccaacta ccctctcccg agttcttttc     6720

ctgggtggac ggagtgcaga tccataggtt tgcccccaca ccgaagccgt ttttccggga     6780

tgaggtctcg ttctgcgttg ggcttaattc atttgtcgtc gggtcccagc ttccttgcga     6840

ccctgaaccc gacacagacg tattgatgtc catgctaaca gatccatctc atatcacggc     6900

ggagactgca gcgcggcgtt tagcgcgggg gtcaccccca tccgaggcaa gctcctcggc     6960

gagccagcta tcggcaccat cgctgcgagc cacctgcacc acccacggca aagcctatga     7020

tgtggacatg gtggatgcta acctgttcat ggggggcgat gtgactcgga tagagtctgg     7080

gtccaaagtg gtcgttctgg actctctcga cccaatggtc gaagaaagga gcgaccttga     7140

gccttcgata ccatcagaat acatgctccc caagaagagg ttcccaccag ctttaccggc     7200

ctgggcacgg cctgattaca acccaccgct tgtggaatcg tggaaaaggc cagattacca     7260

accggccact gttgcgggct gtgctctccc tcctcctagg aaaaccccga cgcctccccc     7320

aaggaggcgc cggacagtgg gcctaagtga ggactccata ggagatgccc ttcaacagct     7380

ggccattaag tcctttggcc agcccccccc aagcggcgat tcaggccttt ccacgggggc     7440

gggcgctgcc gattccggca gtcagacgcc tcctgatgag ttggcccttt cggagacagg     7500

ttccatctct tccatgcccc ccctcgaggg ggagcttgga gatccagacc tggagcctga     7560

gcaggtagag ccccaacccc ccccccaggg gggggtggca gctcccggct cggactcggg     7620

gtcctggtct acttgctccg aggaggacga ctccgtcgtg tgctgctcca tgtcatactc     7680

ctggaccggg gctctaataa ctccttgtag tcccgaagag gagaagttac cgattaaccc     7740

cttgagcaac tccctgttgc gatatcacaa caaggtgtac tgtaccacaa caaagagcgc     7800

ctcactaagg gctaaaaagg taacttttga taggatgcaa gtgctcgact cctactacga     7860

ctcagtctta aaggacatta agctagcggc ctccaaggtc accgcaaggc tcctcaccat     7920

ggaggaggct tgccagttaa ccccacccca ttctgcaaga tctaaatatg ggtttggggc     7980

taaggaggtc cgcagcttgt ccgggagggc cgttaaccac atcaagtccg tgtggaagga     8040

cctcctggag gactcagaaa caccaattcc cacaaccatt atggccaaaa atgaggtgtt     8100

ctgcgtggac cccaccaagg ggggcaagaa agcagctcgc cttatcgttt accctgacct     8160

cggcgtcagg gtctgcgaga agatggccct ttatgacatt acacaaaaac ttcctcaggc     8220

ggtgatgggg gcttcttatg gattccagta ttcccccgct cagcgggtag agtttctctt     8280

gaaagcatgg gcggaaaaga aggaccctat gggtttttcg tatgataccc gatgctttga     8340

ctcaaccgtc actgagagag acatcaggac tgaggagtcc atatatcggg cctgctcctt     8400

gcccgaggag gcccacactg ccatacactc gctaactgag agactttacg tgggagggcc     8460

tatgttcaac agcaagggcc aaacctgcgg gtacaggcgt tgccgcgcca gcggggtgct     8520

caccactagc atggggaaca ccatcacatg ctacgtgaaa gccttagcgg cttgtaaagc     8580

tgcagggata atcgcgccca caatgctggt atgcggcgat gacttggttg tcatctcaga     8640

aagccagggg accgaggagg acgagcggaa cctgagagcc ttcacggagg ctatgaccag     8700

gtattctgcc cctcctggtg acccccccag accggagtat gatctggagc tgataacatc     8760

ttgctcctca aatgtgtctg tggcgctggg cccacaaggc cgccgcagat actacctgac     8820

cagagaccct accactccaa tcgcccgggc tgcctgggaa acagttagac actcccctgt     8880

caattcatgg ctgggaaaca tcatccagta cgccccgacc atatgggctc gcatggtcct     8940

gatgacacac ttcttctcca ttctcatggc tcaagacacg ctggaccaga acctcaactt     9000

tgagatgtac ggagcggtgt actccgtgag tcccttggac ctcccagcta taattgaaag     9060

gttacatggg cttgacgctt tttctctgca cacatacact ccccacgaac tgacacgggt     9120

ggcttcagcc ctcagaaaac ttggggcgcc acccctcaga gcgtggaaga gccgggcacg     9180

tgcagtcagg gcgtccctca tctcccgtgg ggggagagcg gccgtttgcg gtcgatatct     9240

cttcaattgg gcggtgaaga ccaagctcaa actcactcca ttgccggaag cgcgcctcct     9300

ggatttatcc agctggttca ccgtcggcgc cggcgggggc ggcatttatc acagcgtgtc     9360

gcgtgcccga ccccgcttat tgctctttgg cctactccta ctttttgtag gggtaggcct     9420

tttcctactc cccgctcggt agagcggcac acattagcta cactccatag ctaactgtcc     9480

cttttttttt tttttttttt tttttttttt tttttttttt tttttttttt ttcttttttt     9540

ctcttttcct tctttcttac cttattttac tttctttcct ggtggctcca tcttagccct     9600

agtcacggct agctgtgaaa ggtccgtgag ccgcatgact gcagagagtg ccgtaactgg     9660

tctctctgca gatcatgt                                                   9678


<210>  30
<211>  9678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  30
acccgcccct aataggggcg acactccgcc atgaatcact cccctgtgag gaactactgt       60

cttcacgcag aaagcgtcta gccatggcgt tagtatgagt gtcgtacagc ctccaggccc      120

ccccctcccg ggagagccat agtggtctgc ggaaccggtg agtacaccgg aattgccggg      180

aagactgggt cctttcttgg ataaacccac tctatgcccg gccatttggg cgtgcccccg      240

caagactgct agccgagtag cgttgggttg cgaaaggcct tgtggtactg cctgataggg      300

tgcttgcgag tgccccggga ggtctcgtag accgtgcacc atgagcacaa atcctaaacc      360

tcaaagaaaa accaaaagaa acaccaaccg tcgcccacaa gacgttaagt ttccgggcgg      420

cggccagatc gttggcggag tatacttgtt gccgcgcagg ggccccaggt tgggtgtgcg      480

cgcgacaagg aagacttcgg agcggtccca gccacgtgga aggcgccagc ccatccctaa      540

agatcggcgc tccactggca aatcctgggg aaaaccagga tacccctggc ccctatacgg      600

gaatgaggga ctcggctggg caggatggct cctgtccccc cgaggttccc gtccctcttg      660

gggccccaat gacccccggc ataggtcgcg caacgtgggt aaggtcatcg ataccctaac      720

gtgcggcttt gccgacctca tggggtacat ccctgtcgtg ggcgccccgc tcggcggcgt      780

cgccagagct ctcgcgcatg gcgtgagagt cctggaggac ggggttaatt ttgcaacagg      840

gaacttaccc ggttgctcct tttctatctt cttgctggcc ctgctgtcct gcatcaccac      900

cccggtctcc gctgccgaag tgaagaacat cagtaccggc tacatggtga ctaacgactg      960

caccaatgac agcattacct ggcagctcca ggctgctgtc ctccacgtcc ccgggtgcgt     1020

cccgtgcgag aaagtgggga atgcatctca gtgctggata ccggtctcac cgaatgtggc     1080

cgtgcagcgg cccggcgccc tcacgcaggg cttgcggacg cacatcgaca tggttgtgat     1140

gtccgccacg ctctgctctg ccctctacgt gggggacctc tgcggtgggg tgatgctcgc     1200

agcccaaatg ttcattgtct cgccgcagca ccactggttt gtccaagact gcaattgctc     1260

catctaccct ggtaccatca ctggacaccg catggcatgg gacatgatga tgaactggtc     1320

gcccacggct accatgatct tggcgtacgc gatgcgtgtc cccgaggtca ttatagacat     1380

cattagcggg gctcattggg gcgtcatgtt cggcttggcc tacttctcta tgcagggagc     1440

gtgggcgaaa gtcgttgtca tccttctgtt ggccgccggg gtggacgcgc gcacccatac     1500

tgttgggggt tctgccgcgc agaccaccgg gcgcctcacc agcttatttg acatgggccc     1560

caggcagaaa atccagctcg ttaacaccaa tggcagctgg cacatcaacc gcaccgccct     1620

gaactgcaat gactccttgc acaccggctt tatcgcgtct ctgttctaca cccacagctt     1680

caactcgtca ggatgtcccg aacgcatgtc cgcctgccgc agtatcgagg ccttccgggt     1740

gggatggggc gccttgcaat atgaggataa tgtcaccaat ccagaggata tgagacccta     1800

ttgctggcac tacccaccaa ggcagtgtgg cgtggtctcc gcgaagactg tgtgtggccc     1860

agtgtactgt ttcaccccca gcccagtggt agtgggcacg accgacaggc ttggagcgcc     1920

cacttacacg tggggggaga atgagacaga tgtcttccta ttgaacagca ctcgaccacc     1980

gctggggtca tggttcggct gcacgtggat gaactcttct ggctacacca agacttgcgg     2040

cgcaccaccc tgccgtacta gagctgactt caacgccagc acggacctgt tgtgccccac     2100

ggactgtttt aggaagcatc ctgataccac ttacctcaaa tgcggctctg ggccctggct     2160

cacgccaagg tgcctgatcg actaccccta caggctctgg cattacccct gcacagttaa     2220

ctataccatc ttcaaaataa ggatgtatgt gggaggggtt gagcacaggc tcacggctgc     2280

atgcaatttc actcgtgggg atcgttgcaa cttggaggac agagacagaa gtcaactgtc     2340

tcctttgttg cactccacca cggaatgggc cattttacct tgctcttact cggacctgcc     2400

cgccttgtcg actggtcttc tccacctcca ccaaaacatc gtggacgtac aattcatgta     2460

tggcctatca cctgccctca caaaatacat cgtccgatgg gagtgggtaa tactcttatt     2520

cctgctctta gcggacgcca gggtttgcgc ctgcttatgg atgctcatct tgttgggcca     2580

ggccgaagca gcactagaga agctggtcat cttgcacgct gcgagcgcag ctagctgcaa     2640

tggcttccta tattttgtca tctttttcgt ggctgcttgg tacatcaagg gtcgggtagt     2700

ccccttagct acctattccc tcactggcct gtggtccttt agcctactgc tcctagcatt     2760

gccccaacag gcttatgctt atgacgcatc tgtgcatggc cagataggag cggctctgct     2820

ggtaatgatc actctcttta ctctcacccc cgggtataag acccttctca gccggttttt     2880

gtggtggttg tgctatcttc tgaccctggg ggaagctatg gtccaggagt gggcaccacc     2940

tatgcaggtg cgcggtggcc gtgatggcat catatgggcc gtcgccatat tctacccagg     3000

tgtggtgttt gacataacca agtggctctt ggcggtgctt gggcctgctt acctcctaaa     3060

aggtgctttg acgcgcgtgc cgtacttcgt cagggctcac gctctactga ggatgtgcac     3120

catggcaagg catctcgcgg ggggcaggta cgtccagatg gcgctactag cccttggcag     3180

gtggactggc acttacatct atgaccacct cacccctatg tcggattggg ctgctagtgg     3240

cctgcgggac ctggcggtcg ccgttgagcc tatcatcttc agtccgatgg agaagaaagt     3300

cattgtctgg ggagcggaga cagctgcttg tggggacatt ttacacggac ttcccgtgtc     3360

cgcccgactt ggtcgggagg tcctccttgg cccagctgat ggctatacct ccaaggggtg     3420

gagtcttctc gcccccatca ctgcttacgc ccagcagaca cgtggccttt tgggcaccat     3480

agtggtgagc atgacggggc gcgacaagac agaacaggct ggggaaattc aggtcctgtc     3540

cacagtcact cagtccttcc tcggaacatc catctcgggg gttttgtgga ctgtctacca     3600

tggagctggc aacaagactc tggccggctc acggggtctg gtcacgcaga tgtactccag     3660

tgctgagggg gacttagtag ggtggcccag cccccctggg actaaatctt tggagccgtg     3720

cacgtgtgga gcggtcgacc tgtacctggt cacgcggaac gctgatgtca tcccggctcg     3780

aagacgcggg gacaaacggg gagcgctact ctccccgaga cctctttcca ccttgaaggg     3840

gtcctcagga ggcccggtgc tatgccccag gggccacgct gtcggagtct tccgggcagc     3900

tgtgtgctct cggggcgtgg ctaagtccat agatttcatc cccgttgaga cactcgacat     3960

cgtcacgcgg tcccccacct ttagtgacaa cagcacacca cctgctgtgc cccagaccta     4020

tcaggtcggg tacttgcatg ccccgactgg cagtggaaag agcaccaaag ttcctgtcgc     4080

atatgctgct caggggtata aagtgctagt gcttaatccc tcagtggctg ccaccctggg     4140

gtttggggcg tacttgtcta aggcacatgg catcaatccc aacattagga ctggagtcag     4200

gactgtgacg accggggcgc ccatcacgta ctccacatat ggcaaattcc tcgccgatgg     4260

gggctgtgcg ggcggcgcct acgacatcat catatgtgat gaatgccatg ccgtggactc     4320

taccaccatc cttggcatcg gaacagtcct tgatcaagca gagacagctg gggtcagact     4380

aactgtgctg gctacagcta cgccccctgg gtcagtgaca accccccacc ccaacataga     4440

ggaggtggcc cttgggcagg agggcgagat ccccttctat gggagggcga ttcccctgtc     4500

ttacatcaag ggaggaagac atctgatctt ctgccattca aagaaaaagt gtgacgagct     4560

cgcggcggcc cttcggggta tgggcttgaa ctcagtggca tactacagag ggttggacgt     4620

ctccgtaata ccaactcagg gagacgtagt ggtcgtcgcc accgacgccc tcatgacagg     4680

gtatactggg gactttgact ccgtgatcga ctgcaacgta gcggtcactc aagttgtaga     4740

cctcagttta gaccccacat tcaccataac cacacagatt gtccctcaag acgctgtctc     4800

acgtagccag cgccggggtc gcacgggtag gggaagactg ggcatttata ggtatgtttc     4860

cactggtgag cgagcctcag gaatgtttga cagtgtagtg ctctgtgagt gctacgacgc     4920

aggggccgca tggtatgagc tcacaccatc ggagaccacc gtcaggctca gggcgtattt     4980

caacacgccc ggtttgcctg tgtgccaaga ccatcttgag ttttgggagg cagttttcac     5040

cggcctcaca cacatagatg cccacttcct ttcccaaaca aagcaatcgg gggaaaattt     5100

cgcatactta acagcctacc aggctacagt gtgcgctagg gccaaagccc cccccccgtc     5160

ctgggacgtc atgtggaagt gtttgactcg actcaagccc acactcgtgg gccccacacc     5220

tctcctgtac cgcttgggct ctgttaccaa cgaggtcacc ctcacacatc ccgtgacgaa     5280

atacatcgcc acctgcatgc aagccgacct tgaggtcatg accagcacat gggtcttggc     5340

agggggagtc ttggcggccg tcgcctcgta ttgcctggcg accgggtgtg tttgcatcat     5400

cggccgcttg cacattaacc agcgagccgt cgttgcgccg gacaaggagg tcctctatga     5460

ggcttttgat gagatggagg aatgtgcctc tagggcggct ctcattgaag aggggcagcg     5520

gatagccgag atgctgaagt ccaagatcca aggcttattg cagcaagctt ccaaacaagc     5580

tcaagacata caacccactg tgcaggcttc atggcccaag gtagaacaat tctgggccaa     5640

acacatgtgg aacttcatta gcggcatcca atacctcgca ggactatcaa cactgccagg     5700

gaaccctgca gtagcttcca tgatggcgtt cagtgccgcc ctcaccagtc cgctgtcaac     5760

aagcaccact atccttctca acattttggg gggctggcta gcatcccaaa ttgcaccacc     5820

cgcgggggcc actggcttcg ttgtcagtgg cctagtggga gctgccgtag gcagtatagg     5880

cttaggtaag gtgctagtgg acatcctggc agggtatggt gcgggcattt cgggggctct     5940

cgtcgcattc aagatcatgt ctggcgagaa gccctccatg gaggatgtcg tcaacttgct     6000

gcctggaatt ctgtctccgg gtgccttggt agtgggagtc atctgcgcgg ccattctgcg     6060

ccgacacgtg ggaccggggg aaggcgccgt ccaatggatg aatagactca ttgcctttgc     6120

ttccagagga aatcacgtcg cccccaccca ctacgtgacg gagtcggatg cgtcgcagcg     6180

tgtgacccaa ctacttggct cccttaccat aaccagcctg ctcagaagac tccacaactg     6240

gattactgag gactgcccca tcccatgcgg cggctcgtgg ctccgcgatg tgtgggactg     6300

ggtttgcacc atcctaacag actttaaaaa ttggctgacc tccaaattat tcccaaagat     6360

gcccggcctc ccctttgtct cctgtcaaaa ggggtacaag ggcgtgtggg ccggcactgg     6420

catcatgacc acacggtgtc cttgcggcgc caatatctct ggcaatgtcc gcttgggctc     6480

catgagaatc acggggccta agacctgcat gaatatctgg caggggacct ttcctatcaa     6540

ttgttacacg gagggccagt gcgtgccgaa acccgcgcca aactttaagg tcgccatctg     6600

gagggtggcg gcctcagagt acgcggaggt gacgcagcac gggtcatacc actacataac     6660

aggactcacc actgataact tgaaagtccc ctgccaacta ccctctcccg agttcttttc     6720

ctgggtggac ggagtgcaga tccataggtt tgcccccaca ccgaagccgt ttttccggga     6780

tgaggtctcg ttctgcgttg ggcttaattc atttgtcgtc gggtcccagc ttccttgcga     6840

ccctgaaccc gacacagacg tattgatgtc catgctaaca gatccatctc atatcacggc     6900

ggagactgca gcgcggcgtt tagcgcgggg gtcaccccca tccgaggcaa gctcctcggc     6960

gagccagcta tcggcaccat cgctgcgagc cacctgcacc acccacggca aagcctatga     7020

tgtggacatg gtggatgcta acctgttcat ggggggcgat gtgactcgga tagagtctgg     7080

gtccaaagtg gtcgttctgg actctctcga cccaatggtc gaagaaagga gcgaccttga     7140

gccttcgata ccatcagaat acatgctccc caagaagagg ttcccaccag ctttaccggc     7200

ctgggcacgg cctgattaca acccaccgct tgtggaatcg tggaaaaggc cagattacca     7260

accggccact gttgcgggct gtgctctccc tcctcctagg aaaaccccga cgcctccccc     7320

aaggaggcgc cggacagtgg gcctaagtga ggactccata ggagatgccc ttcaacagct     7380

ggccattaag tcctttggcc agcccccccc aagcggcgat tcaggccttt ccacgggggc     7440

gggcgctgcc gattccggca gtcagacgcc tcctgatgag ttggcccttt cggagacagg     7500

ttccatctct tccatgcccc ccctcgaggg ggagcttgga gatccagacc tggagcctga     7560

gcaggtagag ccccaacccc ccccccaggg gggggtggca gctcccggct cggactcggg     7620

gtcctggtct acttgctccg aggaggacga ctccgtcgtg tgctgctcca tgtcatactc     7680

ctggaccggg gctctaataa ctccttgtag tcccgaagag gagaagttac cgattaaccc     7740

cttgagcaac tccctgttgc gatatcacaa caaggtgtac tgtaccacaa caaagagcgc     7800

ctcactaagg gctaaaaagg taacttttga taggatgcaa gtgctcgact cctactacga     7860

ctcagtctta aaggacatta agctagcggc ctccaaggtc accgcaaggc tcctcaccat     7920

ggaggaggct tgccagttaa ccccacccca ttctgcaaga tctaaatatg ggtttggggc     7980

taaggaggtc cgcagcttgt ccgggagggc cgttaaccac atcaagtccg tgtggaagga     8040

cctcctggag gactcagaaa caccaattcc cacaaccatt atggccaaaa atgaggtgtt     8100

ctgcgtggac cccaccaagg ggggcaagaa agcagctcgc cttatcgttt accctgacct     8160

cggcgtcagg gtctgcgaga agatggccct ttatgacatt acacaaaaac ttcctcaggc     8220

ggtgatgggg gcttcttatg gattccagta ttcccccgct cagcgggtag agtttctctt     8280

gaaagcatgg gcggaaaaga aggaccctat gggtttttcg tatgataccc gatgctttga     8340

ctcaaccgtc actgagagag acatcaggac tgaggagtcc atatatcggg cctgctcctt     8400

gcccgaggag gcccacactg ccatacactc gctaactgag agactttacg tgggagggcc     8460

tatgttcaac agcaagggcc aaacctgcgg gtacaggcgt tgccgcgcca gcggggtgct     8520

caccactagc atggggaaca ccatcacatg ctacgtgaaa gccttagcgg cttgtaaagc     8580

tgcagggata atcgcgccca caatgctggt atgcggcgat gacttggttg tcatctcaga     8640

aagccagggg accgaggagg acgagcggaa cctgagagcc ttcacggagg ctatgaccag     8700

gtattctgcc cctcctggtg acccccccag accggagtat gatctggagc tgataacatc     8760

ttgctcctca aatgtgtctg tggcgctggg cccacaaggc cgccgcagat actacctgac     8820

cagagaccct accactccaa tcgcccgggc tgcctgggaa acagttagac actcccctgt     8880

caattcatgg ctgggaaaca tcatccagta cgccccgacc atatgggctc gcatggtcct     8940

gatgacacac ttcttctcca ttctcatggc tcaagacacg ctggaccaga acctcaactt     9000

tgagatgtac ggagcggtgt actccgtgag tcccttggac ctcccagcta taattgaaag     9060

gttacatggg cttgacgctt tttctctgca cacatacact ccccacgaac tgacacgggt     9120

ggcttcagcc ctcagaaaac ttggggcgcc acccctcaga gcgtggaaga gccgggcacg     9180

tgcagtcagg gcgtccctca tctcccgtgg ggggagagcg gccgtttgcg gtcgatatct     9240

cttcaattgg gcggtgaaga ccaagctcaa actcactcca ttgccggaag cgcgcctcct     9300

ggatttatcc agctggttca ccgtcggcgc cggcgggggc ggcatttatc acagcgtgtc     9360

gcgtgcccga ccccgcttat tgctctttgg cctactccta ctttttgtag gggtaggcct     9420

tttcctactc cccgctcggt agagcggcac acattagcta cactccatag ctaactgtcc     9480

cttttttttt tttttttttt tttttttttt tttttttttt tttttttttt ttcttttttt     9540

ctcttttcct tctttcttac cttattttac tttctttcct ggtggctcca tcttagccct     9600

agtcacggct agctgtgaaa ggtccgtgag ccgcatgact gcagagagtg ccgtaactgg     9660

tctctctgca gatcatgt                                                   9678


<210>  31
<211>  9678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  31
acccgcccct aataggggcg acactccgcc atgaatcact cccctgtgag gaactactgt       60

cttcacgcag aaagcgtcta gccatggcgt tagtatgagt gtcgtacagc ctccaggccc      120

ccccctcccg ggagagccat agtggtctgc ggaaccggtg agtacaccgg aattgccggg      180

aagactgggt cctttcttgg ataaacccac tctatgcccg gccatttggg cgtgcccccg      240

caagactgct agccgagtag cgttgggttg cgaaaggcct tgtggtactg cctgataggg      300

tgcttgcgag tgccccggga ggtctcgtag accgtgcacc atgagcacaa atcctaaacc      360

tcaaagaaaa accaaaagaa acaccaaccg tcgcccacaa gacgttaagt ttccgggcgg      420

cggccagatc gttggcggag tatacttgtt gccgcgcagg ggccccaggt tgggtgtgcg      480

cgcgacaagg aagacttcgg agcggtccca gccacgtgga aggcgccagc ccatccctaa      540

agatcggcgc tccactggca aatcctgggg aaaaccagga tacccctggc ccctatacgg      600

gaatgaggga ctcggctggg caggatggct cctgtccccc cgaggttccc gtccctcttg      660

gggccccaat gacccccggc ataggtcgcg caacgtgggt aaggtcatcg ataccctaac      720

gtgcggcttt gccgacctca tggggtacat ccctgtcgtg ggcgccccgc tcggcggcgt      780

cgccagagct ctcgcgcatg gcgtgagagt cctggaggac ggggttaatt ttgcaacagg      840

gaacttaccc ggttgctcct tttctatctt cttgctggcc ctgctgtcct gcatcaccac      900

cccggtctcc gctgccgaag tgaagaacat cagtaccggc tacatggtga ctaacgactg      960

caccaatgac agcattacct ggcagctcca ggctgctgtc ctccacgtcc ccgggtgcgt     1020

cccgtgcgag aaagtgggga atgcatctca gtgctggata ccggtctcac cgaatgtggc     1080

cgtgcagcgg cccggcgccc tcacgcaggg cttgcggacg cacatcgaca tggttgtgat     1140

gtccgccacg ctctgctctg ccctctacgt gggggacctc tgcggtgggg tgatgctcgc     1200

agcccaaatg ttcattgtct cgccgcagca ccactggttt gtccaagact gcaattgctc     1260

catctaccct ggtaccatca ctggacaccg catggcatgg gacatgatga tgaactggtc     1320

gcccacggct accatgatct tggcgtacgc gatgcgtgtc cccgaggtca ttatagacat     1380

cattagcggg gctcattggg gcgtcatgtt cggcttggcc tacttctcta tgcagggagc     1440

gtgggcgaaa gtcgttgtca tccttctgtt ggccgccggg gtggacgcgc gcacccatac     1500

tgttgggggt tctgccgcgc agaccaccgg gcgcctcacc agcttatttg acatgggccc     1560

caggcagaaa atccagctcg ttaacaccaa tggcagctgg cacatcaacc gcaccgccct     1620

gaactgcaat gactccttgc acaccggctt tatcgcgtct ctgttctaca cccacagctt     1680

caactcgtca ggatgtcccg aacgcatgtc cgcctgccgc agtatcgagg ccttccgggt     1740

gggatggggc gccttgcaat atgaggataa tgtcaccaat ccagaggata tgagacccta     1800

ttgctggcac tacccaccaa ggcagtgtgg cgtggtctcc gcgaagactg tgtgtggccc     1860

agtgtactgt ttcaccccca gcccagtggt agtgggcacg accgacaggc ttggagcgcc     1920

cacttacacg tggggggaga atgagacaga tgtcttccta ttgaacagca ctcgaccacc     1980

gctggggtca tggttcggct gcacgtggat gaactcttct ggctacacca agacttgcgg     2040

cgcaccaccc tgccgtacta gagctgactt caacgccagc acggacctgt tgtgccccac     2100

ggactgtttt aggaagcatc ctgataccac ttacctcaaa tgcggctctg ggccctggct     2160

cacgccaagg tgcctgatcg actaccccta caggctctgg cattacccct gcacagttaa     2220

ctataccatc ttcaaaataa ggatgtatgt gggaggggtt gagcacaggc tcacggctgc     2280

atgcaatttc actcgtgggg atcgttgcaa cttggaggac agagacagaa gtcaactgtc     2340

tcctttgttg cactccacca cggaatgggc cattttacct tgctcttact cggacctgcc     2400

cgccttgtcg actggtcttc tccacctcca ccaaaacatc gtggacgtac aattcatgta     2460

tggcctatca cctgccctca caaaatacat cgtccgatgg gagtgggtaa tactcttatt     2520

cctgctctta gcggacgcca gggtttgcgc ctgcttatgg atgctcatct tgttgggcca     2580

ggccgaagca gcactagaga agctggtcat cttgcacgct gcgagcgcag ctagctgcaa     2640

tggcttccta tattttgtca tctttttcgt ggctgcttgg tacatcaagg gtcgggtagt     2700

ccccttagct acctattccc tcactggcct gtggtccttt agcctactgc tcctagcatt     2760

gccccaacag gcttatgctt atgacgcatc tgtgcatggc cagataggag cggctctgct     2820

ggtaatgatc actctcttta ctctcacccc cgggtataag acccttctca gccggttttt     2880

gtggtggttg tgctatcttc tgaccctggg ggaagctatg gtccaggagt gggcaccacc     2940

tatgcaggtg cgcggtggcc gtgatggcat catatgggcc gtcgccatat tctacccagg     3000

tgtggtgttt gacataacca agtggctctt ggcggtgctt gggcctgctt acctcctaaa     3060

aggtgctttg acgcgcgtgc cgtacttcgt cagggctcac gctctactga ggatgtgcac     3120

catggcaagg catctcgcgg ggggcaggta cgtccagatg gcgctactag cccttggcag     3180

gtggactggc acttacatct atgaccacct cacccctatg tcggattggg ctgctagtgg     3240

cctgcgggac ctggcggtcg ccgttgagcc tatcatcttc agtccgatgg agaagaaagt     3300

cattgtctgg ggagcggaga cagctgcttg tggggacatt ttacacggac ttcccgtgtc     3360

cgcccgactt ggtcgggagg tcctccttgg cccagctgat ggctatacct ccaaggggtg     3420

gagtcttctc gcccccatca ctgcttacgc ccagcagaca cgtggccttt tgggcaccat     3480

agtggtgagc atgacggggc gcgacaagac agaacaggct ggggaaattc aggtcctgtc     3540

cacagtcact cagtccttcc tcggaacatc catctcgggg gttttgtgga ctgtctacca     3600

tggagctggc aacaagactc tggccggctc acggggtccg gtcacgcaga tgtactccag     3660

tgctgagggg gacttagtag ggtggcccag cccccctggg actaaatctt tggagccgtg     3720

cacgtgtgga gcggtcgacc tgtacctggt cacgcggaac gctgatgtca tcccggctcg     3780

aagacgcggg gacaaacggg gagcgctact ctccccgaga cctctttcca ccttgaaggg     3840

gtcctcagga ggcccggtgc tatgccccag gggccacgct gtcggagtct tccgggcagc     3900

tgtgtgctct cggggcgtgg ctaagtccat agatttcatc cccgttgaga cactcgacat     3960

cgtcacgcgg tcccccacct ttagtgacaa cagcacacca cctgctgtgc cccagaccta     4020

tcaggtcggg tacttgcatg ccccgactgg cagtggaaag agcaccaaag ttcctgtcgc     4080

atatgctgct caggggtata aagtgctagt gcttaatccc tcagtggctg ccaccctggg     4140

gtttggggcg tacttgtcta aggcacatgg catcaatccc aacattagga ctggagtcag     4200

gactgtgacg accggggcgc ccatcacgta ctccacatat ggcaaattcc tcgccgatgg     4260

gggctgtgcg ggcggcgcct acgacatcat catatgtgat gaatgccatg ccgtggactc     4320

taccaccatc cttggcatcg gaacagtcct tgatcaagca gagacagctg gggtcagact     4380

aactgtgctg gctacagcta cgccccctgg gtcagtgaca accccccacc ccaacataga     4440

ggaggtggcc cttgggcagg agggcgagat ccccttctat gggagggcga ttcccctgtc     4500

ttacatcaag ggaggaagac atctgatctt ctgccattca aagaaaaagt gtgacgagct     4560

cgcggcggcc cttcggggta tgggcttgaa ctcagtggca tactacagag ggttggacgt     4620

ctccgtaata ccaactcagg gagacgtagt ggtcgtcgcc accgacgccc tcatgacagg     4680

gtatactggg gactttgact ccgtgatcga ctgcaacgta gcggtcactc aagttgtaga     4740

cctcagttta gaccccacat tcaccataac cacacagatt gtccctcaag acgctgtctc     4800

acgtagccag cgccggggtc gcacgggtag gggaagactg ggcatttata ggtatgtttc     4860

cactggtgag cgagcctcag gaatgtttga cagtgtagtg ctctgtgagt gctacgacgc     4920

aggggccgca tggtatgagc tcacaccatc ggagaccacc gtcaggctca gggcgtattt     4980

caacacgccc ggtttgcctg tgtgccaaga ccatcttgag ttttgggagg cagttttcac     5040

cggcctcaca cacatagatg cccacttcct ttcccaaaca aagcaatcgg gggaaaattt     5100

cgcatactta acagcctacc aggctacagt gtgcgctagg gccaaagccc cccccccgtc     5160

ctgggacgtc atgtggaagt gtttgactcg actcaagccc acactcgtgg gccccacacc     5220

tctcctgtac cgcttgggct ctgttaccaa cgaggtcacc ctcacacatc ccgtgacgaa     5280

atacatcgcc acctgcatgc aagccgacct tgaggtcatg accagcacat gggtcttggc     5340

agggggagtc ttggcggccg tcgcctcgta ttgcctggcg accgggtgtg tttgcatcat     5400

cggccgcttg cacattaacc agcgagccgt cgttgcgccg gacaaggagg tcctctatga     5460

ggcttttgat gagatggagg aatgtgcctc tagggcggct ctcattgaag aggggcagcg     5520

gatagccgag atgctgaagt ccaagatcca aggcttattg cagcaagctt ccaaacaagc     5580

tcaagacata caacccactg tgcaggcttc atggcccaag gtagaacaat tctgggccaa     5640

acacatgtgg aacttcatta gcggcatcca atacctcgca ggactatcaa cactgccagg     5700

gaaccctgca gtagcttcca tgatggcgtt cagtgccgcc ctcaccagtc cgctgtcaac     5760

aagcaccact atccttctca acattttggg gggctggcta gcatcccaaa ttgcaccacc     5820

cgcgggggcc actggcttcg ttgtcagtgg cctagtggga gctgccgtag gcagtatagg     5880

cttaggtaag gtgctagtgg acatcctggc agggtatggt gcgggcattt cgggggctct     5940

cgtcgcattc aagatcatgt ctggcgagaa gccctccatg gaggatgtcg tcaacttgct     6000

gcctggaatt ctgtctccgg gtgccttggt agtgggagtc atctgcgcgg ccattctgcg     6060

ccgacacgtg ggaccggggg aaggcgccgt ccaatggatg aatagactca ttgcctttgc     6120

ttccagagga agtcacgtcg cccccaccca ctacgtgacg gagtcggatg cgtcgcagcg     6180

tgtgacccaa ctacttggct cccttaccat aaccagcctg ctcagaagac tccacaactg     6240

gattactgag gactgcccca tcccatgcgg cggctcgtgg ctccgcgatg tgtgggactg     6300

ggtttgcacc atcctaacag actttaaaaa ttggctgacc tccaaattat tcccaaagat     6360

gcccggcctc ccctttgtct cctgtcaaaa ggggtacaag ggcgtgtggg ccggcactgg     6420

catcatgacc acacggtgtc cttgcggcgc caatatctct ggcaatgtcc gcttgggctc     6480

catgagaatc acggggccta agacctgcat gaatatctgg caggggacct ttcctatcaa     6540

ttgttacacg gagggccagt gcgtgccgaa acccgcgcca aactttaagg tcgccatctg     6600

gagggtggcg gcctcagagt acgcggaggt gacgcagcac gggtcatacc actacataac     6660

aggactcacc actgataact tgaaagtccc ctgccaacta ccctctcccg agttcttttc     6720

ctgggtggac ggagtgcaga tccataggtt tgcccccaca ccgaagccgt ttttccggga     6780

tgaggtctcg ttctgcgttg ggcttaattc atttgtcgtc gggtcccagc ttccttgcga     6840

ccctgaaccc gacacagacg tattgatgtc catgctaaca gatccatctc atatcacggc     6900

ggagactgca gcgcggcgtt tagcgcgggg gtcaccccca tccgaggcaa gctcctcggc     6960

gagccagcta tcggcaccat cgctgcgagc cacctgcacc acccacggca aagcctatga     7020

tgtggacatg gtggatgcta acctgttcat ggggggcgat gtgactcgga tagagtctgg     7080

gtccaaagtg gtcgttctgg actctctcga cccaatggtc gaagaaagga gcgaccttga     7140

gccttcgata ccatcagaat acatgctccc caagaagagg ttcccaccag ctttaccggc     7200

ctgggcacgg cctgattaca acccaccgct tgtggaatcg tggaaaaggc cagattacca     7260

accggccact gttgcgggct gtgctctccc tcctcctagg aaaaccccga cgcctccccc     7320

aaggaggcgc cggacagtgg gcctaagtga ggactccata ggagatgccc ttcaacagct     7380

ggccattaag tcctttggcc agcccccccc aagcggcgat tcaggccttt ccacgggggc     7440

gggcgctgcc gattccggca gtcagacgcc tcctgatgag ttggcccttt cggagacagg     7500

ttccatctct tccatgcccc ccctcgaggg ggagcttgga gatccagacc tggagcctga     7560

gcaggtagag ccccaacccc ccccccaggg gggggtggca gctcccggct cggactcggg     7620

gtcctggtct acttgctccg aggaggacga ctccgtcgtg tgctgctcca tgtcatactc     7680

ctggaccggg gctctaataa ctccttgtag tcccgaagag gagaagttac cgattaaccc     7740

cttgagcaac tccctgttgc gatatcacaa caaggtgtac tgtaccacaa caaagagcgc     7800

ctcactaagg gctaaaaagg taacttttga taggatgcaa gtgctcgact cctactacga     7860

ctcagtctta aaggacatta agctagcggc ctccaaggtc accgcaaggc tcctcaccat     7920

ggaggaggct tgccagttaa ccccacccca ttctgcaaga tctaaatatg ggtttggggc     7980

taaggaggtc cgcagcttgt ccgggagggc cgttaaccac atcaagtccg tgtggaagga     8040

cctcctggag gactcagaaa caccaattcc cacaaccatt atggccaaaa atgaggtgtt     8100

ctgcgtggac cccaccaagg ggggcaagaa agcagctcgc cttatcgttt accctgacct     8160

cggcgtcagg gtctgcgaga agatggccct ttatgacatt acacaaaaac ttcctcaggc     8220

ggtgatgggg gcttcttatg gattccagta ttcccccgct cagcgggtag agtttctctt     8280

gaaagcatgg gcggaaaaga aggaccctat gggtttttcg tatgataccc gatgctttga     8340

ctcaaccgtc actgagagag acatcaggac tgaggagtcc atatatcggg cctgctcctt     8400

gcccgaggag gcccacactg ccatacactc gctaactgag agactttacg tgggagggcc     8460

tatgttcaac agcaagggcc aaacctgcgg gtacaggcgt tgccgcgcca gcggggtgct     8520

caccactagc atggggaaca ccatcacatg ctacgtgaaa gccttagcgg cttgtaaagc     8580

tgcagggata atcgcgccca caatgctggt atgcggcgat gacttggttg tcatctcaga     8640

aagccagggg accgaggagg acgagcggaa cctgagagcc ttcacggagg ctatgaccag     8700

gtattctgcc cctcctggtg acccccccag accggagtat gatctggagc tgataacatc     8760

ttgctcctca aatgtgtctg tggcgctggg cccacaaggc cgccgcagat actacctgac     8820

cagagaccct accactccaa tcgcccgggc tgcctgggaa acagttagac actcccctgt     8880

caattcatgg ctgggaaaca tcatccagta cgccccgacc atatgggctc gcatggtcct     8940

gatgacacac ttcttctcca ttctcatggc tcaagacacg ctggaccaga acctcaactt     9000

tgagatgtac ggagcggtgt actccgtgag tcccttggac ctcccagcta taattgaaag     9060

gttacatggg cttgacgctt tttctctgca cacatacact ccccacgaac tgacacgggt     9120

ggcttcagcc ctcagaaaac ttggggcgcc acccctcaga gcgtggaaga gccgggcacg     9180

tgcagtcagg gcgtccctca tctcccgtgg ggggagagcg gccgtttgcg gtcgatatct     9240

cttcaattgg gcggtgaaga ccaagctcaa actcactcca ttgccggaag cgcgcctcct     9300

ggatttatcc agctggttca ccgtcggcgc cggcgggggc ggcatttatc acagcgtgtc     9360

gcgtgcccga ccccgcttat tgctctttgg cctactccta ctttttgtag gggtaggcct     9420

tttcctactc cccgctcggt agagcggcac acattagcta cactccatag ctaactgtcc     9480

cttttttttt tttttttttt tttttttttt tttttttttt tttttttttt ttcttttttt     9540

ctcttttcct tctttcttac cttattttac tttctttcct ggtggctcca tcttagccct     9600

agtcacggct agctgtgaaa ggtccgtgag ccgcatgact gcagagagtg ccgtaactgg     9660

tctctctgca gatcatgt                                                   9678


<210>  32
<211>  9678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  32
acccgcccct aataggggcg acactccgcc atgaatcact cccctgtgag gaactactgt       60

cttcacgcag aaagcgtcta gccatggcgt tagtatgagt gtcgtacagc ctccaggccc      120

ccccctcccg ggagagccat agtggtctgc ggaaccggtg agtacaccgg aattgccggg      180

aagactgggt cctttcttgg ataaacccac tctatgcccg gccatttggg cgtgcccccg      240

caagactgct agccgagtag cgttgggttg cgaaaggcct tgtggtactg cctgataggg      300

tgcttgcgag tgccccggga ggtctcgtag accgtgcacc atgagcacaa atcctaaacc      360

tcaaagaaaa accaaaagaa acaccaaccg tcgcccacaa gacgttaagt ttccgggcgg      420

cggccagatc gttggcggag tatacttgtt gccgcgcagg ggccccaggt tgggtgtgcg      480

cgcgacaagg aagacttcgg agcggtccca gccacgtgga aggcgccagc ccatccctaa      540

agatcggcgc tccactggca aatcctgggg aaaaccagga tacccctggc ccctatacgg      600

gaatgaggga ctcggctggg caggatggct cctgtccccc cgaggttccc gtccctcttg      660

gggccccaat gacccccggc ataggtcgcg caacgtgggt aaggtcatcg ataccctaac      720

gtgcggcttt gccgacctca tggggtacat ccctgtcgtg ggcgccccgc tcggcggcgt      780

cgccagagct ctcgcgcatg gcgtgagagt cctggaggac ggggttaatt ttgcaacagg      840

gaacttaccc ggttgctcct tttctatctt cttgctggcc ctgctgtcct gcatcaccac      900

cccggtctcc gctgccgaag tgaagaacat cagtaccggc tacatggtga ctaacgactg      960

caccaatgac agcattacct ggcagctcca ggctgctgtc ctccacgtcc ccgggtgcgt     1020

cccgtgcgag aaagtgggga atgcatctca gtgctggata ccggtctcac cgaatgtggc     1080

cgtgcagcgg cccggcgccc tcacgcaggg cttgcggacg cacatcgaca tggttgtgat     1140

gtccgccacg ctctgctctg ccctctacgt gggggacctc tgcggtgggg tgatgctcgc     1200

agcccaaatg ttcattgtct cgccgcagca ccactggttt gtccaagact gcaattgctc     1260

catctaccct ggtaccatca ctggacaccg catggcatgg gacatgatga tgaactggtc     1320

gcccacggct accatgatct tggcgtacgc gatgcgtgtc cccgaggtca ttatagacat     1380

cattagcggg gctcattggg gcgtcatgtt cggcttggcc tacttctcta tgcagggagc     1440

gtgggcgaaa gtcgttgtca tccttctgtt ggccgccggg gtggacgcgc gcacccatac     1500

tgttgggggt tctgccgcgc agaccaccgg gcgcctcacc agcttatttg acatgggccc     1560

caggcagaaa atccagctcg ttaacaccaa tggcagctgg cacatcaacc gcaccgccct     1620

gaactgcaat gactccttgc acaccggctt tatcgcgtct ctgttctaca cccacagctt     1680

caactcgtca ggatgtcccg aacgcatgtc cgcctgccgc agtatcgagg ccttccgggt     1740

gggatggggc gccttgcaat atgaggataa tgtcaccaat ccagaggata tgagacccta     1800

ttgctggcac tacccaccaa ggcagtgtgg cgtggtctcc gcgaagactg tgtgtggccc     1860

agtgtactgt ttcaccccca gcccagtggt agtgggcacg accgacaggc ttggagcgcc     1920

cacttacacg tggggggaga atgagacaga tgtcttccta ttgaacagca ctcgaccacc     1980

gctggggtca tggttcggct gcacgtggat gaactcttct ggctacacca agacttgcgg     2040

cgcaccaccc tgccgtacta gagctgactt caacgccagc acggacctgt tgtgccccac     2100

ggactgtttt aggaagcatc ctgataccac ttacctcaaa tgcggctctg ggccctggct     2160

cacgccaagg tgcctgatcg actaccccta caggctctgg cattacccct gcacagttaa     2220

ctataccatc ttcaaaataa ggatgtatgt gggaggggtt gagcacaggc tcacggctgc     2280

atgcaatttc actcgtgggg atcgttgcaa cttggaggac agagacagaa gtcaactgtc     2340

tcctttgttg cactccacca cggaatgggc cattttacct tgctcttact cggacctgcc     2400

cgccttgtcg actggtcttc tccacctcca ccaaaacatc gtggacgtac aattcatgta     2460

tggcctatca cctgccctca caaaatacat cgtccgatgg gagtgggtaa tactcttatt     2520

cctgctctta gcggacgcca gggtttgcgc ctgcttatgg atgctcatct tgttgggcca     2580

ggccgaagca gcactagaga agctggtcat cttgcacgct gcgagcgcag ctagctgcaa     2640

tggcttccta tattttgtca tctttttcgt ggctgcttgg tacatcaagg gtcgggtagt     2700

ccccttagct acctattccc tcactggcct gtggtccttt agcctactgc tcctagcatt     2760

gccccaacag gcttatgctt atgacgcatc tgtgcatggc cagataggag cggctctgct     2820

ggtaatgatc actctcttta ctctcacccc cgggtataag acccttctca gccggttttt     2880

gtggtggttg tgctatcttc tgaccctggg ggaagctatg gtccaggagt gggcaccacc     2940

tatgcaggtg cgcggtggcc gtgatggcat catatgggcc gtcgccatat tctacccagg     3000

tgtggtgttt gacataacca agtggctctt ggcggtgctt gggcctgctt acctcctaaa     3060

aggtgctttg acgcgcgtgc cgtacttcgt cagggctcac gctctactga ggatgtgcac     3120

catggcaagg catctcgcgg ggggcaggta cgtccagatg gcgctactag cccttggcag     3180

gtggactggc acttacatct atgaccacct cacccctatg tcggattggg ctgctagtgg     3240

cctgcgggac ctggcggtcg ccgttgagcc tatcatcttc agtccgatgg agaagaaagt     3300

cattgtctgg ggagcggaga cagctgcttg tggggacatt ttacacggac ttcccgtgtc     3360

cgcccgactt ggtcgggagg tcctccttgg cccagctgat ggctatacct ccaaggggtg     3420

gagtcttctc gcccccatca ctgcttacgc ccagcagaca cgtggccttt tgggcaccat     3480

agtggtgagc atgacggggc gcgacaagac agaacaggct ggggaaattc aggtcctgtc     3540

cacagtcact cagtccttcc tcggaacatc catctcgggg gttttgtgga ctgtctacca     3600

tggagctggc aacaagactc tggccggctc acggggtccg gtcacgcaga tgtactccag     3660

tgctgagggg gacttagtag ggtggcccag cccccctggg actaaatctt tggagccgtg     3720

cacgtgtgga gcggtcgacc tgtacctggt cacgcggaac gctgatgtca tcccggctcg     3780

aagacgcggg gacaaacggg gagcgctact ctccccgaga cctctttcca ccttgaaggg     3840

gtcctcagga ggcccggtgc tatgccccag gggccacgct gtcggagtct tccgggcagc     3900

tgtgtgctct cggggcgtgg ctaagtccat agatttcatc cccgttgaga cactcgacat     3960

cgtcacgcgg tcccccacct ttagtgacaa cagcacacca cctgctgtgc cccagaccta     4020

tcaggtcggg tacttgcatg ccccgactgg cagtggaaag agcaccaaag ttcctgtcgc     4080

atatgctgct caggggtata aagtgctagt gcttaatccc tcagtggctg ccaccctggg     4140

gtttggggcg tacttgtcta aggcacatgg catcaatccc aacattagga ctggagtcag     4200

gactgtgacg accggggcgc ccatcacgta ctccacatat ggcaaattcc tcgccgatgg     4260

gggctgtgcg ggcggcgcct acgacatcat catatgtgat gaatgccatg ccgtggactc     4320

taccaccatc cttggcatcg gaacagtcct tgatcaagca gagacagctg gggtcagact     4380

aactgtgctg gctacagcta cgccccctgg gtcagtgaca accccccacc ccaacataga     4440

ggaggtggcc cttgggcagg agggcgagat ccccttctat gggagggcga ttcccctgtc     4500

ttacatcaag ggaggaagac atctgatctt ctgccattca aagaaaaagt gtgacgagct     4560

cgcggcggcc cttcggggta tgggcttgaa ctcagtggca tactacagag ggttggacgt     4620

ctccgtaata ccaactcagg gagacgtagt ggtcgtcgcc accgacgccc tcatgacagg     4680

gtatactggg gactttgact ccgtgatcga ctgcaacgta gcggtcactc aagttgtaga     4740

cctcagttta gaccccacat tcaccataac cacacagatt gtccctcaag acgctgtctc     4800

acgtagccag cgccggggtc gcacgggtag gggaagactg ggcatttata ggtatgtttc     4860

cactggtgag cgagcctcag gaatgtttga cagtgtagtg ctctgtgagt gctacgacgc     4920

aggggccgca tggtatgagc tcacaccatc ggagaccacc gtcaggctca gggcgtattt     4980

caacacgccc ggtttgcctg tgtgccaaga ccatcttgag ttttgggagg cagttttcac     5040

cggcctcaca cacatagatg cccacttcct ttcccaaaca aagcaatcgg gggaaaattt     5100

cgcatactta acagcctacc aggctacagt gtgcgctagg gccaaagccc cccccccgtc     5160

ctgggacgtc atgtggaagt gtttgactcg actcaagccc acactcgtgg gccccacacc     5220

tctcctgtac cgcttgggct ctgttaccaa cgaggtcacc ctcacacatc ccgtgacgaa     5280

atacatcgcc acctgcatgc aagccgacct tgaggtcatg accagcacat gggtcttggc     5340

agggggagtc ttggcggccg tcgcctcgta ttgcctggcg accgggtgtg tttgcatcat     5400

cggccgcttg cacattaacc agcgagccgt cgttgcgccg gacaaggagg tcctctatga     5460

ggcttttgat gagatggagg aatgtgcctc tagggcggct ctcattgaag aggggcagcg     5520

gatagccgag atgctgaagt ccaagatcca aggcttattg cagcaagctt ccaaacaagc     5580

tcaagacata caacccactg tgcaggcttc atggcccaag gtagaacaat tctgggccaa     5640

acacatgtgg aacttcatta gcggcatcca atacctcgca ggactatcaa cactgccagg     5700

gaaccctgca gtagcttcca tgatggcgtt cagtgccgcc ctcaccagtc cgctgtcaac     5760

aagcaccact atccttctca acattttggg gggctggcta gcatcccaaa ttgcaccacc     5820

cgcgggggcc actggcttcg ttgtcagtgg cctagtggga gctgccgtag gcagtatagg     5880

cttaggtaag gtgctagtgg acatcctggc agggtatggt gcgggcattt cgggggctct     5940

cgtcgcattc aagatcatgt ctggcgagaa gccctccatg gaggatgtcg tcaacttgct     6000

gcctggaatt ctgtctccgg gtgccttggt agtgggagtc atctgcgcgg ccattctgcg     6060

ccgacacgtg ggaccggggg aaggcgccgt ccaatggatg aatagactca ttgcctttgc     6120

ttccagagga actcacgtcg cccccaccca ctacgtgacg gagtcggatg cgtcgcagcg     6180

tgtgacccaa ctacttggct cccttaccat aaccagcctg ctcagaagac tccacaactg     6240

gattactgag gactgcccca tcccatgcgg cggctcgtgg ctccgcgatg tgtgggactg     6300

ggtttgcacc atcctaacag actttaaaaa ttggctgacc tccaaattat tcccaaagat     6360

gcccggcctc ccctttgtct cctgtcaaaa ggggtacaag ggcgtgtggg ccggcactgg     6420

catcatgacc acacggtgtc cttgcggcgc caatatctct ggcaatgtcc gcttgggctc     6480

catgagaatc acggggccta agacctgcat gaatatctgg caggggacct ttcctatcaa     6540

ttgttacacg gagggccagt gcgtgccgaa acccgcgcca aactttaagg tcgccatctg     6600

gagggtggcg gcctcagagt acgcggaggt gacgcagcac gggtcatacc actacataac     6660

aggactcacc actgataact tgaaagtccc ctgccaacta ccctctcccg agttcttttc     6720

ctgggtggac ggagtgcaga tccataggtt tgcccccaca ccgaagccgt ttttccggga     6780

tgaggtctcg ttctgcgttg ggcttaattc atttgtcgtc gggtcccagc ttccttgcga     6840

ccctgaaccc gacacagacg tattgatgtc catgctaaca gatccatctc atatcacggc     6900

ggagactgca gcgcggcgtt tagcgcgggg gtcaccccca tccgaggcaa gctcctcggc     6960

gagccagcta tcggcaccat cgctgcgagc cacctgcacc acccacggca aagcctatga     7020

tgtggacatg gtggatgcta acctgttcat ggggggcgat gtgactcgga tagagtctgg     7080

gtccaaagtg gtcgttctgg actctctcga cccaatggtc gaagaaagga gcgaccttga     7140

gccttcgata ccatcagaat acatgctccc caagaagagg ttcccaccag ctttaccggc     7200

ctgggcacgg cctgattaca acccaccgct tgtggaatcg tggaaaaggc cagattacca     7260

accggccact gttgcgggct gtgctctccc tcctcctagg aaaaccccga cgcctccccc     7320

aaggaggcgc cggacagtgg gcctaagtga ggactccata ggagatgccc ttcaacagct     7380

ggccattaag tcctttggcc agcccccccc aagcggcgat tcaggccttt ccacgggggc     7440

gggcgctgcc gattccggca gtcagacgcc tcctgatgag ttggcccttt cggagacagg     7500

ttccatctct tccatgcccc ccctcgaggg ggagcttgga gatccagacc tggagcctga     7560

gcaggtagag ccccaacccc ccccccaggg gggggtggca gctcccggct cggactcggg     7620

gtcctggtct acttgctccg aggaggacga ctccgtcgtg tgctgctcca tgtcatactc     7680

ctggaccggg gctctaataa ctccttgtag tcccgaagag gagaagttac cgattaaccc     7740

cttgagcaac tccctgttgc gatatcacaa caaggtgtac tgtaccacaa caaagagcgc     7800

ctcactaagg gctaaaaagg taacttttga taggatgcaa gtgctcgact cctactacga     7860

ctcagtctta aaggacatta agctagcggc ctccaaggtc accgcaaggc tcctcaccat     7920

ggaggaggct tgccagttaa ccccacccca ttctgcaaga tctaaatatg ggtttggggc     7980

taaggaggtc cgcagcttgt ccgggagggc cgttaaccac atcaagtccg tgtggaagga     8040

cctcctggag gactcagaaa caccaattcc cacaaccatt atggccaaaa atgaggtgtt     8100

ctgcgtggac cccaccaagg ggggcaagaa agcagctcgc cttatcgttt accctgacct     8160

cggcgtcagg gtctgcgaga agatggccct ttatgacatt acacaaaaac ttcctcaggc     8220

ggtgatgggg gcttcttatg gattccagta ttcccccgct cagcgggtag agtttctctt     8280

gaaagcatgg gcggaaaaga aggaccctat gggtttttcg tatgataccc gatgctttga     8340

ctcaaccgtc actgagagag acatcaggac tgaggagtcc atatatcggg cctgctcctt     8400

gcccgaggag gcccacactg ccatacactc gctaactgag agactttacg tgggagggcc     8460

tatgttcaac agcaagggcc aaacctgcgg gtacaggcgt tgccgcgcca gcggggtgct     8520

caccactagc atggggaaca ccatcacatg ctacgtgaaa gccttagcgg cttgtaaagc     8580

tgcagggata atcgcgccca caatgctggt atgcggcgat gacttggttg tcatctcaga     8640

aagccagggg accgaggagg acgagcggaa cctgagagcc ttcacggagg ctatgaccag     8700

gtattctgcc cctcctggtg acccccccag accggagtat gatctggagc tgataacatc     8760

ttgctcctca aatgtgtctg tggcgctggg cccacaaggc cgccgcagat actacctgac     8820

cagagaccct accactccaa tcgcccgggc tgcctgggaa acagttagac actcccctgt     8880

caattcatgg ctgggaaaca tcatccagta cgccccgacc atatgggctc gcatggtcct     8940

gatgacacac ttcttctcca ttctcatggc tcaagacacg ctggaccaga acctcaactt     9000

tgagatgtac ggagcggtgt actccgtgag tcccttggac ctcccagcta taattgaaag     9060

gttacatggg cttgacgctt tttctctgca cacatacact ccccacgaac tgacacgggt     9120

ggcttcagcc ctcagaaaac ttggggcgcc acccctcaga gcgtggaaga gccgggcacg     9180

tgcagtcagg gcgtccctca tctcccgtgg ggggagagcg gccgtttgcg gtcgatatct     9240

cttcaattgg gcggtgaaga ccaagctcaa actcactcca ttgccggaag cgcgcctcct     9300

ggatttatcc agctggttca ccgtcggcgc cggcgggggc ggcatttatc acagcgtgtc     9360

gcgtgcccga ccccgcttat tgctctttgg cctactccta ctttttgtag gggtaggcct     9420

tttcctactc cccgctcggt agagcggcac acattagcta cactccatag ctaactgtcc     9480

cttttttttt tttttttttt tttttttttt tttttttttt tttttttttt ttcttttttt     9540

ctcttttcct tctttcttac cttattttac tttctttcct ggtggctcca tcttagccct     9600

agtcacggct agctgtgaaa ggtccgtgag ccgcatgact gcagagagtg ccgtaactgg     9660

tctctctgca gatcatgt                                                   9678


<210>  33
<211>  9678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  33
acccgcccct aataggggcg acactccgcc atgaatcact cccctgtgag gaactactgt       60

cttcacgcag aaagcgtcta gccatggcgt tagtatgagt gtcgtacagc ctccaggccc      120

ccccctcccg ggagagccat agtggtctgc ggaaccggtg agtacaccgg aattgccggg      180

aagactgggt cctttcttgg ataaacccac tctatgcccg gccatttggg cgtgcccccg      240

caagactgct agccgagtag cgttgggttg cgaaaggcct tgtggtactg cctgataggg      300

tgcttgcgag tgccccggga ggtctcgtag accgtgcacc atgagcacaa atcctaaacc      360

tcaaagaaaa accaaaagaa acaccaaccg tcgcccacaa gacgttaagt ttccgggcgg      420

cggccagatc gttggcggag tatacttgtt gccgcgcagg ggccccaggt tgggtgtgcg      480

cgcgacaagg aagacttcgg agcggtccca gccacgtgga aggcgccagc ccatccctaa      540

agatcggcgc tccactggca aatcctgggg aaaaccagga tacccctggc ccctatacgg      600

gaatgaggga ctcggctggg caggatggct cctgtccccc cgaggttccc gtccctcttg      660

gggccccaat gacccccggc ataggtcgcg caacgtgggt aaggtcatcg ataccctaac      720

gtgcggcttt gccgacctca tggggtacat ccctgtcgtg ggcgccccgc tcggcggcgt      780

cgccagagct ctcgcgcatg gcgtgagagt cctggaggac ggggttaatt ttgcaacagg      840

gaacttaccc ggttgctcct tttctatctt cttgctggcc ctgctgtcct gcatcaccac      900

cccggtctcc gctgccgaag tgaagaacat cagtaccggc tacatggtga ctaacgactg      960

caccaatgac agcattacct ggcagctcca ggctgctgtc ctccacgtcc ccgggtgcgt     1020

cccgtgcgag aaagtgggga atgcatctca gtgctggata ccggtctcac cgaatgtggc     1080

cgtgcagcgg cccggcgccc tcacgcaggg cttgcggacg cacatcgaca tggttgtgat     1140

gtccgccacg ctctgctctg ccctctacgt gggggacctc tgcggtgggg tgatgctcgc     1200

agcccaaatg ttcattgtct cgccgcagca ccactggttt gtccaagact gcaattgctc     1260

catctaccct ggtaccatca ctggacaccg catggcatgg gacatgatga tgaactggtc     1320

gcccacggct accatgatct tggcgtacgc gatgcgtgtc cccgaggtca ttatagacat     1380

cattagcggg gctcattggg gcgtcatgtt cggcttggcc tacttctcta tgcagggagc     1440

gtgggcgaaa gtcgttgtca tccttctgtt ggccgccggg gtggacgcgc gcacccatac     1500

tgttgggggt tctgccgcgc agaccaccgg gcgcctcacc agcttatttg acatgggccc     1560

caggcagaaa atccagctcg ttaacaccaa tggcagctgg cacatcaacc gcaccgccct     1620

gaactgcaat gactccttgc acaccggctt tatcgcgtct ctgttctaca cccacagctt     1680

caactcgtca ggatgtcccg aacgcatgtc cgcctgccgc agtatcgagg ccttccgggt     1740

gggatggggc gccttgcaat atgaggataa tgtcaccaat ccagaggata tgagacccta     1800

ttgctggcac tacccaccaa ggcagtgtgg cgtggtctcc gcgaagactg tgtgtggccc     1860

agtgtactgt ttcaccccca gcccagtggt agtgggcacg accgacaggc ttggagcgcc     1920

cacttacacg tggggggaga atgagacaga tgtcttccta ttgaacagca ctcgaccacc     1980

gctggggtca tggttcggct gcacgtggat gaactcttct ggctacacca agacttgcgg     2040

cgcaccaccc tgccgtacta gagctgactt caacgccagc acggacctgt tgtgccccac     2100

ggactgtttt aggaagcatc ctgataccac ttacctcaaa tgcggctctg ggccctggct     2160

cacgccaagg tgcctgatcg actaccccta caggctctgg cattacccct gcacagttaa     2220

ctataccatc ttcaaaataa ggatgtatgt gggaggggtt gagcacaggc tcacggctgc     2280

atgcaatttc actcgtgggg atcgttgcaa cttggaggac agagacagaa gtcaactgtc     2340

tcctttgttg cactccacca cggaatgggc cattttacct tgctcttact cggacctgcc     2400

cgccttgtcg actggtcttc tccacctcca ccaaaacatc gtggacgtac aattcatgta     2460

tggcctatca cctgccctca caaaatacat cgtccgatgg gagtgggtaa tactcttatt     2520

cctgctctta gcggacgcca gggtttgcgc ctgcttatgg atgctcatct tgttgggcca     2580

ggccgaagca gcactagaga agctggtcat cttgcacgct gcgagcgcag ctagctgcaa     2640

tggcttccta tattttgtca tcttttccgt ggctgcttgg tacatcaagg gtcgggtagt     2700

ccccttagct acctattccc tcactggcct gtggtccttt agcctactgc tcctagcatt     2760

gccccaacag gcttatgctt atgacgcatc tgtgcatggc cagataggag cggctctgct     2820

ggtaatgatc actctcttta ctctcacccc cgggtataag acccttctca gccggttttt     2880

gtggtggttg tgctatcttc tgaccctggg ggaagctatg gtccaggagt gggcaccacc     2940

tatgcaggtg cgcggtggcc gtgatggcat catatgggcc gtcgccatat tctacccagg     3000

tgtggtgttt gacataacca agtggctctt ggcggtgctt gggcctgctt acctcctaaa     3060

aggtgctttg acgcgcgtgc cgtacttcgt cagggctcac gctctactga ggatgtgcac     3120

catggcaagg catctcgcgg ggggcaggta cgtccagatg gcgctactag cccttggcag     3180

gtggactggc acttacatct atgaccacct cacccctatg tcggattggg ctgctagtgg     3240

cctgcgggac ctggcggtcg ccgttgagcc tatcatcttc agtccgatgg agaagaaagt     3300

cattgtctgg ggagcggaga cagctgcttg tggggacatt ttacacggac ttcccgtgtc     3360

cgcccgactt ggtcgggagg tcctccttgg cccagctgat ggctatacct ccaaggggtg     3420

gagtcttctc gcccccatca ctgcttacgc ccagcagaca cgtggccttt tgggcaccat     3480

agtggtgagc atgacggggc gcgacaagac agaacaggct ggggaaattc aggtcctgtc     3540

cacagtcact cagtccttcc tcggaacatc catctcgggg gttttgtgga ctgtctacca     3600

tggagctggc aacaagactc tggccggctc acggggtctg gtcacgcaga tgtactccag     3660

tgctgagggg gacttagtag ggtggcccag cccccctggg actaaatctt tggagccgtg     3720

cacgtgtgga gcggtcgacc tgtacctggt cacgcggaac gctgatgtca tcccggctcg     3780

aagacgcggg gacaaacggg gagcgctact ctccccgaga cctctttcca ccttgaaggg     3840

gtcctcagga ggcccggtgc tatgccccag gggccacgct gtcggagtct tccgggcagc     3900

tgtgtgctct cggggcgtgg ctaagtccat agatttcatc cccgttgaga cactcgacat     3960

cgtcacgcgg tcccccacct ttagtgacaa cagcacacca cctgctgtgc cccagaccta     4020

tcaggtcggg tacttgcatg ccccgactgg cagtggaaag agcaccaaag ttcctgtcgc     4080

atatgctgct caggggtata aagtgctagt gcttaatccc tcagtggctg ccaccctggg     4140

gtttggggcg tacttgtcta aggcacatgg catcaatccc aacattagga ctggagtcag     4200

gactgtgacg accggggcgc ccatcacgta ctccacatat ggcaaattcc tcgccgatgg     4260

gggctgtgcg ggcggcgcct acgacatcat catatgtgat gaatgccatg ccgtggactc     4320

taccaccatc cttggcatcg gaacagtcct tgatcaagca gagacagctg gggtcagact     4380

aactgtgctg gctacagcta cgccccctgg gtcagtgaca accccccacc ccaacataga     4440

ggaggtggcc cttgggcagg agggcgagat ccccttctat gggagggcga ttcccctgtc     4500

ttacatcaag ggaggaagac atctgatctt ctgccattca aagaaaaagt gtgacgagct     4560

cgcggcggcc cttcggggta tgggcttgaa ctcagtggca tactacagag ggttggacgt     4620

ctccgtaata ccaactcagg gagacgtagt ggtcgtcgcc accgacgccc tcatgacagg     4680

gtatactggg gactttgact ccgtgatcga ctgcaacgta gcggtcactc aagttgtaga     4740

cctcagttta gaccccacat tcaccataac cacacagatt gtccctcaag acgctgtctc     4800

acgtagccag cgccggggtc gcacgggtag gggaagactg ggcatttata ggtatgtttc     4860

cactggtgag cgagcctcag gaatgtttga cagtgtagtg ctctgtgagt gctacgacgc     4920

aggggccgca tggtatgagc tcacaccatc ggagaccacc gtcaggctca gggcgtattt     4980

caacacgccc ggtttgcctg tgtgccaaga ccatcttgag ttttgggagg cagttttcac     5040

cggcctcaca cacatagatg cccacttcct ttcccaaaca aagcaatcgg gggaaaattt     5100

cgcatactta acagcctacc aggctacagt gtgcgctagg gccaaagccc cccccccgtc     5160

ctgggacgtc atgtggaagt gtttgactcg actcaagccc acactcgtgg gccccacacc     5220

tctcctgtac cgcttgggct ctgttaccaa cgaggtcacc ctcacacatc ccgtgacgaa     5280

atacatcgcc acctgcatgc aagccgacct tgaggtcatg accagcacat gggtcttggc     5340

agggggagtc ttggcggccg tcgcctcgta ttgcctggcg accgggtgtg tttgcatcat     5400

cggccgcttg cacattaacc agcgagccgt cgttgcgccg gacaaggagg tcctctatga     5460

ggcttttgat gagatggagg aatgtgcctc tagggcggct ctcattgaag aggggcagcg     5520

gatagccgag atgctgaagt ccaagatcca aggcttattg cagcaagctt ccaaacaagc     5580

tcaagacata caacccactg tgcaggcttc atggcccaag gtagaacaat tctgggccaa     5640

acacatgtgg aacttcatta gcggcatcca atacctcgca ggactatcaa cactgccagg     5700

gaaccctgca gtagcttcca tgatggcgtt cagtgccgcc ctcaccagtc cgctgtcaac     5760

aagcaccact atccttctca acattttggg gggctggcta gcatcccaaa ttgcaccacc     5820

cgcgggggcc actggcttcg ttgtcagtgg cctagtggga gctgccgtag gcagtatagg     5880

cttaggtaag gtgctagtgg acatcctggc agggtatggt gcgggcattt cgggggctct     5940

cgtcgcattc aagatcatgt ctggcgagaa gccctccatg gaggatgtcg tcaacttgct     6000

gcctggaatt ctgtctccgg gtgccttggt agtgggagtc atctgcgcgg ccattctgcg     6060

ccgacacgtg ggaccggggg aaggcgccgt ccaatggatg aatagactca ttgcctttgc     6120

ttccagagga aatcacgtcg cccccaccca ctacgtgacg gagtcggatg cgtcgcagcg     6180

tgtgacccaa ctacttggct cccttaccat aaccagcctg ctcagaagac tccacaactg     6240

gattactgag gactgcccca tcccatgcgg cggctcgtgg ctccgcgatg tgtgggactg     6300

ggtttgcacc atcctaacag actttaaaaa ttggctgacc tccaaattat tcccaaagat     6360

gcccggcctc ccctttgtct cctgtcaaaa ggggtacaag ggcgtgtggg ccggcactgg     6420

catcatgacc acacggtgtc cttgcggcgc caatatctct ggcaatgtcc gcttgggctc     6480

catgagaatc acggggccta agacctgcat gaatatctgg caggggacct ttcctatcaa     6540

ttgttacacg gagggccagt gcgtgccgaa acccgcgcca aactttaagg tcgccatctg     6600

gagggtggcg gcctcagagt acgcggaggt gacgcagcac gggtcatacc actacataac     6660

aggactcacc actgataact tgaaagtccc ctgccaacta ccctctcccg agttcttttc     6720

ctgggtggac ggagtgcaga tccataggtt tgcccccaca ccgaagccgt ttttccggga     6780

tgaggtctcg ttctgcgttg ggcttaattc atttgtcgtc gggtcccagc ttccttgcga     6840

ccctgaaccc gacacagacg tattgatgtc catgctaaca gatccatctc atatcacggc     6900

ggagactgca gcgcggcgtt tagcgcgggg gtcaccccca tccgaggcaa gctcctcggc     6960

gagccagcta tcggcaccat cgctgcgagc cacctgcacc acccacggca aagcctatga     7020

tgtggacatg gtggatgcta acctgttcat ggggggcgat gtgactcgga tagagtctgg     7080

gtccaaagtg gtcgttctgg actctctcga cccaatggtc gaagaaagga gcgaccttga     7140

gccttcgata ccatcagaat acatgctccc caagaagagg ttcccaccag ctttaccggc     7200

ctgggcacgg cctgattaca acccaccgct tgtggaatcg tggaaaaggc cagattacca     7260

accggccact gttgcgggct gtgctctccc tcctcctagg aaaaccccga cgcctccccc     7320

aaggaggcgc cggacagtgg gcctaagtga ggactccata ggagatgccc ttcaacagct     7380

ggccattaag tcctttggcc agcccccccc aagcggcgat tcaggccttt ccacgggggc     7440

gggcgctgcc gattccggca gtcagacgcc tcctgatgag ttggcccttt cggagacagg     7500

ttccatctct tccatgcccc ccctcgaggg ggagcttgga gatccagacc tggagcctga     7560

gcaggtagag ccccaacccc ccccccaggg gggggtggca gctcccggct cggactcggg     7620

gtcctggtct acttgctccg aggaggacga ctccgtcgtg tgctgctcca tgtcatactc     7680

ctggaccggg gctctaataa ctccttgtag tcccgaagag gagaagttac cgattaaccc     7740

cttgagcaac tccctgttgc gatatcacaa caaggtgtac tgtaccacaa caaagagcgc     7800

ctcactaagg gctaaaaagg taacttttga taggatgcaa gtgctcgact cctactacga     7860

ctcagtctta aaggacatta agctagcggc ctccaaggtc accgcaaggc tcctcaccat     7920

ggaggaggct tgccagttaa ccccacccca ttctgcaaga tctaaatatg ggtttggggc     7980

taaggaggtc cgcagcttgt ccgggagggc cgttaaccac atcaagtccg tgtggaagga     8040

cctcctggag gactcagaaa caccaattcc cacaaccatt atggccaaaa atgaggtgtt     8100

ctgcgtggac cccaccaagg ggggcaagaa agcagctcgc cttatcgttt accctgacct     8160

cggcgtcagg gtctgcgaga agatggccct ttatgacatt acacaaaaac ttcctcaggc     8220

ggtgatgggg gcttcttatg gattccagta ttcccccgct cagcgggtag agtttctctt     8280

gaaagcatgg gcggaaaaga aggaccctat gggtttttcg tatgataccc gatgctttga     8340

ctcaaccgtc actgagagag acatcaggac tgaggagtcc atatatcggg cctgctcctt     8400

gcccgaggag gcccacactg ccatacactc gctaactgag agactttacg tgggagggcc     8460

tatgttcaac agcaagggcc aaacctgcgg gtacaggcgt tgccgcgcca gcggggtgct     8520

caccactagc atggggaaca ccatcacatg ctacgtgaaa gccttagcgg cttgtaaagc     8580

tgcagggata atcgcgccca caatgctggt atgcggcgat gacttggttg tcatctcaga     8640

aagccagggg accgaggagg acgagcggaa cctgagagcc ttcacggagg ctatgaccag     8700

gtattctgcc cctcctggtg acccccccag accggagtat gatctggagc tgataacatc     8760

ttgctcctca aatgtgtctg tggcgctggg cccacaaggc cgccgcagat actacctgac     8820

cagagaccct accactccaa tcgcccgggc tgcctgggaa acagttagac actcccctgt     8880

caattcatgg ctgggaaaca tcatccagta cgccccgacc atatgggctc gcatggtcct     8940

gatgacacac ttcttctcca ttctcatggc tcaagacacg ctggaccaga acctcaactt     9000

tgagatgtac ggagcggtgt actccgtgag tcccttggac ctcccagcta taattgaaag     9060

gttacatggg cttgacgctt tttctctgca cacatacact ccccacgaac tgacacgggt     9120

ggcttcagcc ctcagaaaac ttggggcgcc acccctcaga gcgtggaaga gccgggcacg     9180

tgcagtcagg gcgtccctca tctcccgtgg ggggagagcg gccgtttgcg gtcgatatct     9240

cttcaattgg gcggtgaaga ccaagctcaa actcactcca ttgccggaag cgcgcctcct     9300

ggatttatcc agctggttca ccgtcggcgc cggcgggggc ggcatttatc acagcgtgtc     9360

gcgtgcccga ccccgcttat tgctctttgg cctactccta ctttttgtag gggtaggcct     9420

tttcctactc cccgctcggt agagcggcac acattagcta cactccatag ctaactgtcc     9480

cttttttttt tttttttttt tttttttttt tttttttttt tttttttttt ttcttttttt     9540

ctcttttcct tctttcttac cttattttac tttctttcct ggtggctcca tcttagccct     9600

agtcacggct agctgtgaaa ggtccgtgag ccgcatgact gcagagagtg ccgtaactgg     9660

tctctctgca gatcatgt                                                   9678


<210>  34
<211>  9678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  34
acccgcccct aataggggcg acactccgcc atgaatcact cccctgtgag gaactactgt       60

cttcacgcag aaagcgtcta gccatggcgt tagtatgagt gtcgtacagc ctccaggccc      120

ccccctcccg ggagagccat agtggtctgc ggaaccggtg agtacaccgg aattgccggg      180

aagactgggt cctttcttgg ataaacccac tctatgcccg gccatttggg cgtgcccccg      240

caagactgct agccgagtag cgttgggttg cgaaaggcct tgtggtactg cctgataggg      300

tgcttgcgag tgccccggga ggtctcgtag accgtgcacc atgagcacaa atcctaaacc      360

tcaaagaaaa accaaaagaa acaccaaccg tcgcccacaa gacgttaagt ttccgggcgg      420

cggccagatc gttggcggag tatacttgtt gccgcgcagg ggccccaggt tgggtgtgcg      480

cgcgacaagg aagacttcgg agcggtccca gccacgtgga aggcgccagc ccatccctaa      540

agatcggcgc tccactggca aatcctgggg aaaaccagga tacccctggc ccctatacgg      600

gaatgaggga ctcggctggg caggatggct cctgtccccc cgaggttccc gtccctcttg      660

gggccccaat gacccccggc ataggtcgcg caacgtgggt aaggtcatcg ataccctaac      720

gtgcggcttt gccgacctca tggggtacat ccctgtcgtg ggcgccccgc tcggcggcgt      780

cgccagagct ctcgcgcatg gcgtgagagt cctggaggac ggggttaatt ttgcaacagg      840

gaacttaccc ggttgctcct tttctatctt cttgctggcc ctgctgtcct gcatcaccac      900

cccggtctcc gctgccgaag tgaagaacat cagtaccggc tacatggtga ctaacgactg      960

caccaatgac agcattacct ggcagctcca ggctgctgtc ctccacgtcc ccgggtgcgt     1020

cccgtgcgag aaagtgggga atgcatctca gtgctggata ccggtctcac cgaatgtggc     1080

cgtgcagcgg cccggcgccc tcacgcaggg cttgcggacg cacatcgaca tggttgtgat     1140

gtccgccacg ctctgctctg ccctctacgt gggggacctc tgcggtgggg tgatgctcgc     1200

agcccaaatg ttcattgtct cgccgcagca ccactggttt gtccaagact gcaattgctc     1260

catctaccct ggtaccatca ctggacaccg catggcatgg gacatgatga tgaactggtc     1320

gcccacggct accatgatct tggcgtacgc gatgcgtgtc cccgaggtca ttatagacat     1380

cattagcggg gctcattggg gcgtcatgtt cggcttggcc tacttctcta tgcagggagc     1440

gtgggcgaaa gtcgttgtca tccttctgtt ggccgccggg gtggacgcgc gcacccatac     1500

tgttgggggt tctgccgcgc agaccaccgg gcgcctcacc agcttatttg acatgggccc     1560

caggcagaaa atccagctcg ttaacaccaa tggcagctgg cacatcaacc gcaccgccct     1620

gaactgcaat gactccttgc acaccggctt tatcgcgtct ctgttctaca cccacagctt     1680

caactcgtca ggatgtcccg aacgcatgtc cgcctgccgc agtatcgagg ccttccgggt     1740

gggatggggc gccttgcaat atgaggataa tgtcaccaat ccagaggata tgagacccta     1800

ttgctggcac tacccaccaa ggcagtgtgg cgtggtctcc gcgaagactg tgtgtggccc     1860

agtgtactgt ttcaccccca gcccagtggt agtgggcacg accgacaggc ttggagcgcc     1920

cacttacacg tggggggaga atgagacaga tgtcttccta ttgaacagca ctcgaccacc     1980

gctggggtca tggttcggct gcacgtggat gaactcttct ggctacacca agacttgcgg     2040

cgcaccaccc tgccgtacta gagctgactt caacgccagc acggacctgt tgtgccccac     2100

ggactgtttt aggaagcatc ctgataccac ttacctcaaa tgcggctctg ggccctggct     2160

cacgccaagg tgcctgatcg actaccccta caggctctgg cattacccct gcacagttaa     2220

ctataccatc ttcaaaataa ggatgtatgt gggaggggtt gagcacaggc tcacggctgc     2280

atgcaatttc actcgtgggg atcgttgcaa cttggaggac agagacagaa gtcaactgtc     2340

tcctttgttg cactccacca cggaatgggc cattttacct tgctcttact cggacctgcc     2400

cgccttgtcg actggtcttc tccacctcca ccaaaacatc gtggacgtac aattcatgta     2460

tggcctatca cctgccctca caaaatacat cgtccgatgg gagtgggtaa tactcttatt     2520

cctgctctta gcggacgcca gggtttgcgc ctgcttatgg atgctcatct tgttgggcca     2580

ggccgaagca gcactagaga agctggtcat cttgcacgct gcgagcgcag ctagctgcaa     2640

tggcttccta tattttgtca tcttttccgt ggctgcttgg tacatcaagg gtcgggtagt     2700

ccccttagct acctattccc tcactggcct gtggtccttt agcctactgc tcctagcatt     2760

gccccaacag gcttatgctt atgacgcatc tgtgcatggc cagataggag cggctctgct     2820

ggtaatgatc actctcttta ctctcacccc cgggtataag acccttctca gccggttttt     2880

gtggtggttg tgctatcttc tgaccctggg ggaagctatg gtccaggagt gggcaccacc     2940

tatgcaggtg cgcggtggcc gtgatggcat catatgggcc gtcgccatat tctacccagg     3000

tgtggtgttt gacataacca agtggctctt ggcggtgctt gggcctgctt acctcctaaa     3060

aggtgctttg acgcgcgtgc cgtacttcgt cagggctcac gctctactga ggatgtgcac     3120

catggcaagg catctcgcgg ggggcaggta cgtccagatg gcgctactag cccttggcag     3180

gtggactggc acttacatct atgaccacct cacccctatg tcggattggg ctgctagtgg     3240

cctgcgggac ctggcggtcg ccgttgagcc tatcatcttc agtccgatgg agaagaaagt     3300

cattgtctgg ggagcggaga cagctgcttg tggggacatt ttacacggac ttcccgtgtc     3360

cgcccgactt ggtcgggagg tcctccttgg cccagctgat ggctatacct ccaaggggtg     3420

gagtcttctc gcccccatca ctgcttacgc ccagcagaca cgtggccttt tgggcaccat     3480

agtggtgagc atgacggggc gcgacaagac agaacaggct ggggaaattc aggtcctgtc     3540

cacagtcact cagtccttcc tcggaacatc catctcgggg gttttgtgga ctgtctacca     3600

tggagctggc aacaagactc tggccggctc acggggtccg gtcacgcaga tgtactccag     3660

tgctgagggg gacttagtag ggtggcccag cccccctggg actaaatctt tggagccgtg     3720

cacgtgtgga gcggtcgacc tgtacctggt cacgcggaac gctgatgtca tcccggctcg     3780

aagacgcggg gacaaacggg gagcgctact ctccccgaga cctctttcca ccttgaaggg     3840

gtcctcagga ggcccggtgc tatgccccag gggccacgct gtcggagtct tccgggcagc     3900

tgtgtgctct cggggcgtgg ctaagtccat agatttcatc cccgttgaga cactcgacat     3960

cgtcacgcgg tcccccacct ttagtgacaa cagcacacca cctgctgtgc cccagaccta     4020

tcaggtcggg tacttgcatg ccccgactgg cagtggaaag agcaccaaag ttcctgtcgc     4080

atatgctgct caggggtata aagtgctagt gcttaatccc tcagtggctg ccaccctggg     4140

gtttggggcg tacttgtcta aggcacatgg catcaatccc aacattagga ctggagtcag     4200

gactgtgacg accggggcgc ccatcacgta ctccacatat ggcaaattcc tcgccgatgg     4260

gggctgtgcg ggcggcgcct acgacatcat catatgtgat gaatgccatg ccgtggactc     4320

taccaccatc cttggcatcg gaacagtcct tgatcaagca gagacagctg gggtcagact     4380

aactgtgctg gctacagcta cgccccctgg gtcagtgaca accccccacc ccaacataga     4440

ggaggtggcc cttgggcagg agggcgagat ccccttctat gggagggcga ttcccctgtc     4500

ttacatcaag ggaggaagac atctgatctt ctgccattca aagaaaaagt gtgacgagct     4560

cgcggcggcc cttcggggta tgggcttgaa ctcagtggca tactacagag ggttggacgt     4620

ctccgtaata ccaactcagg gagacgtagt ggtcgtcgcc accgacgccc tcatgacagg     4680

gtatactggg gactttgact ccgtgatcga ctgcaacgta gcggtcactc aagttgtaga     4740

cctcagttta gaccccacat tcaccataac cacacagatt gtccctcaag acgctgtctc     4800

acgtagccag cgccggggtc gcacgggtag gggaagactg ggcatttata ggtatgtttc     4860

cactggtgag cgagcctcag gaatgtttga cagtgtagtg ctctgtgagt gctacgacgc     4920

aggggccgca tggtatgagc tcacaccatc ggagaccacc gtcaggctca gggcgtattt     4980

caacacgccc ggtttgcctg tgtgccaaga ccatcttgag ttttgggagg cagttttcac     5040

cggcctcaca cacatagatg cccacttcct ttcccaaaca aagcaatcgg gggaaaattt     5100

cgcatactta acagcctacc aggctacagt gtgcgctagg gccaaagccc cccccccgtc     5160

ctgggacgtc atgtggaagt gtttgactcg actcaagccc acactcgtgg gccccacacc     5220

tctcctgtac cgcttgggct ctgttaccaa cgaggtcacc ctcacacatc ccgtgacgaa     5280

atacatcgcc acctgcatgc aagccgacct tgaggtcatg accagcacat gggtcttggc     5340

agggggagtc ttggcggccg tcgcctcgta ttgcctggcg accgggtgtg tttgcatcat     5400

cggccgcttg cacattaacc agcgagccgt cgttgcgccg gacaaggagg tcctctatga     5460

ggcttttgat gagatggagg aatgtgcctc tagggcggct ctcattgaag aggggcagcg     5520

gatagccgag atgctgaagt ccaagatcca aggcttattg cagcaagctt ccaaacaagc     5580

tcaagacata caacccactg tgcaggcttc atggcccaag gtagaacaat tctgggccaa     5640

acacatgtgg aacttcatta gcggcatcca atacctcgca ggactatcaa cactgccagg     5700

gaaccctgca gtagcttcca tgatggcgtt cagtgccgcc ctcaccagtc cgctgtcaac     5760

aagcaccact atccttctca acattttggg gggctggcta gcatcccaaa ttgcaccacc     5820

cgcgggggcc actggcttcg ttgtcagtgg cctagtggga gctgccgtag gcagtatagg     5880

cttaggtaag gtgctagtgg acatcctggc agggtatggt gcgggcattt cgggggctct     5940

cgtcgcattc aagatcatgt ctggcgagaa gccctccatg gaggatgtcg tcaacttgct     6000

gcctggaatt ctgtctccgg gtgccttggt agtgggagtc atctgcgcgg ccattctgcg     6060

ccgacacgtg ggaccggggg aaggcgccgt ccaatggatg aatagactca ttgcctttgc     6120

ttccagagga agtcacgtcg cccccaccca ctacgtgacg gagtcggatg cgtcgcagcg     6180

tgtgacccaa ctacttggct cccttaccat aaccagcctg ctcagaagac tccacaactg     6240

gattactgag gactgcccca tcccatgcgg cggctcgtgg ctccgcgatg tgtgggactg     6300

ggtttgcacc atcctaacag actttaaaaa ttggctgacc tccaaattat tcccaaagat     6360

gcccggcctc ccctttgtct cctgtcaaaa ggggtacaag ggcgtgtggg ccggcactgg     6420

catcatgacc acacggtgtc cttgcggcgc caatatctct ggcaatgtcc gcttgggctc     6480

catgagaatc acggggccta agacctgcat gaatatctgg caggggacct ttcctatcaa     6540

ttgttacacg gagggccagt gcgtgccgaa acccgcgcca aactttaagg tcgccatctg     6600

gagggtggcg gcctcagagt acgcggaggt gacgcagcac gggtcatacc actacataac     6660

aggactcacc actgataact tgaaagtccc ctgccaacta ccctctcccg agttcttttc     6720

ctgggtggac ggagtgcaga tccataggtt tgcccccaca ccgaagccgt ttttccggga     6780

tgaggtctcg ttctgcgttg ggcttaattc atttgtcgtc gggtcccagc ttccttgcga     6840

ccctgaaccc gacacagacg tattgatgtc catgctaaca gatccatctc atatcacggc     6900

ggagactgca gcgcggcgtt tagcgcgggg gtcaccccca tccgaggcaa gctcctcggc     6960

gagccagcta tcggcaccat cgctgcgagc cacctgcacc acccacggca aagcctatga     7020

tgtggacatg gtggatgcta acctgttcat ggggggcgat gtgactcgga tagagtctgg     7080

gtccaaagtg gtcgttctgg actctctcga cccaatggtc gaagaaagga gcgaccttga     7140

gccttcgata ccatcagaat acatgctccc caagaagagg ttcccaccag ctttaccggc     7200

ctgggcacgg cctgattaca acccaccgct tgtggaatcg tggaaaaggc cagattacca     7260

accggccact gttgcgggct gtgctctccc tcctcctagg aaaaccccga cgcctccccc     7320

aaggaggcgc cggacagtgg gcctaagtga ggactccata ggagatgccc ttcaacagct     7380

ggccattaag tcctttggcc agcccccccc aagcggcgat tcaggccttt ccacgggggc     7440

gggcgctgcc gattccggca gtcagacgcc tcctgatgag ttggcccttt cggagacagg     7500

ttccatctct tccatgcccc ccctcgaggg ggagcttgga gatccagacc tggagcctga     7560

gcaggtagag ccccaacccc ccccccaggg gggggtggca gctcccggct cggactcggg     7620

gtcctggtct acttgctccg aggaggacga ctccgtcgtg tgctgctcca tgtcatactc     7680

ctggaccggg gctctaataa ctccttgtag tcccgaagag gagaagttac cgattaaccc     7740

cttgagcaac tccctgttgc gatatcacaa caaggtgtac tgtaccacaa caaagagcgc     7800

ctcactaagg gctaaaaagg taacttttga taggatgcaa gtgctcgact cctactacga     7860

ctcagtctta aaggacatta agctagcggc ctccaaggtc accgcaaggc tcctcaccat     7920

ggaggaggct tgccagttaa ccccacccca ttctgcaaga tctaaatatg ggtttggggc     7980

taaggaggtc cgcagcttgt ccgggagggc cgttaaccac atcaagtccg tgtggaagga     8040

cctcctggag gactcagaaa caccaattcc cacaaccatt atggccaaaa atgaggtgtt     8100

ctgcgtggac cccaccaagg ggggcaagaa agcagctcgc cttatcgttt accctgacct     8160

cggcgtcagg gtctgcgaga agatggccct ttatgacatt acacaaaaac ttcctcaggc     8220

ggtgatgggg gcttcttatg gattccagta ttcccccgct cagcgggtag agtttctctt     8280

gaaagcatgg gcggaaaaga aggaccctat gggtttttcg tatgataccc gatgctttga     8340

ctcaaccgtc actgagagag acatcaggac tgaggagtcc atatatcggg cctgctcctt     8400

gcccgaggag gcccacactg ccatacactc gctaactgag agactttacg tgggagggcc     8460

tatgttcaac agcaagggcc aaacctgcgg gtacaggcgt tgccgcgcca gcggggtgct     8520

caccactagc atggggaaca ccatcacatg ctacgtgaaa gccttagcgg cttgtaaagc     8580

tgcagggata atcgcgccca caatgctggt atgcggcgat gacttggttg tcatctcaga     8640

aagccagggg accgaggagg acgagcggaa cctgagagcc ttcacggagg ctatgaccag     8700

gtattctgcc cctcctggtg acccccccag accggagtat gatctggagc tgataacatc     8760

ttgctcctca aatgtgtctg tggcgctggg cccacaaggc cgccgcagat actacctgac     8820

cagagaccct accactccaa tcgcccgggc tgcctgggaa acagttagac actcccctgt     8880

caattcatgg ctgggaaaca tcatccagta cgccccgacc atatgggctc gcatggtcct     8940

gatgacacac ttcttctcca ttctcatggc tcaagacacg ctggaccaga acctcaactt     9000

tgagatgtac ggagcggtgt actccgtgag tcccttggac ctcccagcta taattgaaag     9060

gttacatggg cttgacgctt tttctctgca cacatacact ccccacgaac tgacacgggt     9120

ggcttcagcc ctcagaaaac ttggggcgcc acccctcaga gcgtggaaga gccgggcacg     9180

tgcagtcagg gcgtccctca tctcccgtgg ggggagagcg gccgtttgcg gtcgatatct     9240

cttcaattgg gcggtgaaga ccaagctcaa actcactcca ttgccggaag cgcgcctcct     9300

ggatttatcc agctggttca ccgtcggcgc cggcgggggc ggcatttatc acagcgtgtc     9360

gcgtgcccga ccccgcttat tgctctttgg cctactccta ctttttgtag gggtaggcct     9420

tttcctactc cccgctcggt agagcggcac acattagcta cactccatag ctaactgtcc     9480

cttttttttt tttttttttt tttttttttt tttttttttt tttttttttt ttcttttttt     9540

ctcttttcct tctttcttac cttattttac tttctttcct ggtggctcca tcttagccct     9600

agtcacggct agctgtgaaa ggtccgtgag ccgcatgact gcagagagtg ccgtaactgg     9660

tctctctgca gatcatgt                                                   9678


<210>  35
<211>  9678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  35
acccgcccct aataggggcg acactccgcc atgaatcact cccctgtgag gaactactgt       60

cttcacgcag aaagcgtcta gccatggcgt tagtatgagt gtcgtacagc ctccaggccc      120

ccccctcccg ggagagccat agtggtctgc ggaaccggtg agtacaccgg aattgccggg      180

aagactgggt cctttcttgg ataaacccac tctatgcccg gccatttggg cgtgcccccg      240

caagactgct agccgagtag cgttgggttg cgaaaggcct tgtggtactg cctgataggg      300

tgcttgcgag tgccccggga ggtctcgtag accgtgcacc atgagcacaa atcctaaacc      360

tcaaagaaaa accaaaagaa acaccaaccg tcgcccacaa gacgttaagt ttccgggcgg      420

cggccagatc gttggcggag tatacttgtt gccgcgcagg ggccccaggt tgggtgtgcg      480

cgcgacaagg aagacttcgg agcggtccca gccacgtgga aggcgccagc ccatccctaa      540

agatcggcgc tccactggca aatcctgggg aaaaccagga tacccctggc ccctatacgg      600

gaatgaggga ctcggctggg caggatggct cctgtccccc cgaggttccc gtccctcttg      660

gggccccaat gacccccggc ataggtcgcg caacgtgggt aaggtcatcg ataccctaac      720

gtgcggcttt gccgacctca tggggtacat ccctgtcgtg ggcgccccgc tcggcggcgt      780

cgccagagct ctcgcgcatg gcgtgagagt cctggaggac ggggttaatt ttgcaacagg      840

gaacttaccc ggttgctcct tttctatctt cttgctggcc ctgctgtcct gcatcaccac      900

cccggtctcc gctgccgaag tgaagaacat cagtaccggc tacatggtga ctaacgactg      960

caccaatgac agcattacct ggcagctcca ggctgctgtc ctccacgtcc ccgggtgcgt     1020

cccgtgcgag aaagtgggga atgcatctca gtgctggata ccggtctcac cgaatgtggc     1080

cgtgcagcgg cccggcgccc tcacgcaggg cttgcggacg cacatcgaca tggttgtgat     1140

gtccgccacg ctctgctctg ccctctacgt gggggacctc tgcggtgggg tgatgctcgc     1200

agcccaaatg ttcattgtct cgccgcagca ccactggttt gtccaagact gcaattgctc     1260

catctaccct ggtaccatca ctggacaccg catggcatgg gacatgatga tgaactggtc     1320

gcccacggct accatgatct tggcgtacgc gatgcgtgtc cccgaggtca ttatagacat     1380

cattagcggg gctcattggg gcgtcatgtt cggcttggcc tacttctcta tgcagggagc     1440

gtgggcgaaa gtcgttgtca tccttctgtt ggccgccggg gtggacgcgc gcacccatac     1500

tgttgggggt tctgccgcgc agaccaccgg gcgcctcacc agcttatttg acatgggccc     1560

caggcagaaa atccagctcg ttaacaccaa tggcagctgg cacatcaacc gcaccgccct     1620

gaactgcaat gactccttgc acaccggctt tatcgcgtct ctgttctaca cccacagctt     1680

caactcgtca ggatgtcccg aacgcatgtc cgcctgccgc agtatcgagg ccttccgggt     1740

gggatggggc gccttgcaat atgaggataa tgtcaccaat ccagaggata tgagacccta     1800

ttgctggcac tacccaccaa ggcagtgtgg cgtggtctcc gcgaagactg tgtgtggccc     1860

agtgtactgt ttcaccccca gcccagtggt agtgggcacg accgacaggc ttggagcgcc     1920

cacttacacg tggggggaga atgagacaga tgtcttccta ttgaacagca ctcgaccacc     1980

gctggggtca tggttcggct gcacgtggat gaactcttct ggctacacca agacttgcgg     2040

cgcaccaccc tgccgtacta gagctgactt caacgccagc acggacctgt tgtgccccac     2100

ggactgtttt aggaagcatc ctgataccac ttacctcaaa tgcggctctg ggccctggct     2160

cacgccaagg tgcctgatcg actaccccta caggctctgg cattacccct gcacagttaa     2220

ctataccatc ttcaaaataa ggatgtatgt gggaggggtt gagcacaggc tcacggctgc     2280

atgcaatttc actcgtgggg atcgttgcaa cttggaggac agagacagaa gtcaactgtc     2340

tcctttgttg cactccacca cggaatgggc cattttacct tgctcttact cggacctgcc     2400

cgccttgtcg actggtcttc tccacctcca ccaaaacatc gtggacgtac aattcatgta     2460

tggcctatca cctgccctca caaaatacat cgtccgatgg gagtgggtaa tactcttatt     2520

cctgctctta gcggacgcca gggtttgcgc ctgcttatgg atgctcatct tgttgggcca     2580

ggccgaagca gcactagaga agctggtcat cttgcacgct gcgagcgcag ctagctgcaa     2640

tggcttccta tattttgtca tcttttccgt ggctgcttgg tacatcaagg gtcgggtagt     2700

ccccttagct acctattccc tcactggcct gtggtccttt agcctactgc tcctagcatt     2760

gccccaacag gcttatgctt atgacgcatc tgtgcatggc cagataggag cggctctgct     2820

ggtaatgatc actctcttta ctctcacccc cgggtataag acccttctca gccggttttt     2880

gtggtggttg tgctatcttc tgaccctggg ggaagctatg gtccaggagt gggcaccacc     2940

tatgcaggtg cgcggtggcc gtgatggcat catatgggcc gtcgccatat tctacccagg     3000

tgtggtgttt gacataacca agtggctctt ggcggtgctt gggcctgctt acctcctaaa     3060

aggtgctttg acgcgcgtgc cgtacttcgt cagggctcac gctctactga ggatgtgcac     3120

catggcaagg catctcgcgg ggggcaggta cgtccagatg gcgctactag cccttggcag     3180

gtggactggc acttacatct atgaccacct cacccctatg tcggattggg ctgctagtgg     3240

cctgcgggac ctggcggtcg ccgttgagcc tatcatcttc agtccgatgg agaagaaagt     3300

cattgtctgg ggagcggaga cagctgcttg tggggacatt ttacacggac ttcccgtgtc     3360

cgcccgactt ggtcgggagg tcctccttgg cccagctgat ggctatacct ccaaggggtg     3420

gagtcttctc gcccccatca ctgcttacgc ccagcagaca cgtggccttt tgggcaccat     3480

agtggtgagc atgacggggc gcgacaagac agaacaggct ggggaaattc aggtcctgtc     3540

cacagtcact cagtccttcc tcggaacatc catctcgggg gttttgtgga ctgtctacca     3600

tggagctggc aacaagactc tggccggctc acggggtccg gtcacgcaga tgtactccag     3660

tgctgagggg gacttagtag ggtggcccag cccccctggg actaaatctt tggagccgtg     3720

cacgtgtgga gcggtcgacc tgtacctggt cacgcggaac gctgatgtca tcccggctcg     3780

aagacgcggg gacaaacggg gagcgctact ctccccgaga cctctttcca ccttgaaggg     3840

gtcctcagga ggcccggtgc tatgccccag gggccacgct gtcggagtct tccgggcagc     3900

tgtgtgctct cggggcgtgg ctaagtccat agatttcatc cccgttgaga cactcgacat     3960

cgtcacgcgg tcccccacct ttagtgacaa cagcacacca cctgctgtgc cccagaccta     4020

tcaggtcggg tacttgcatg ccccgactgg cagtggaaag agcaccaaag ttcctgtcgc     4080

atatgctgct caggggtata aagtgctagt gcttaatccc tcagtggctg ccaccctggg     4140

gtttggggcg tacttgtcta aggcacatgg catcaatccc aacattagga ctggagtcag     4200

gactgtgacg accggggcgc ccatcacgta ctccacatat ggcaaattcc tcgccgatgg     4260

gggctgtgcg ggcggcgcct acgacatcat catatgtgat gaatgccatg ccgtggactc     4320

taccaccatc cttggcatcg gaacagtcct tgatcaagca gagacagctg gggtcagact     4380

aactgtgctg gctacagcta cgccccctgg gtcagtgaca accccccacc ccaacataga     4440

ggaggtggcc cttgggcagg agggcgagat ccccttctat gggagggcga ttcccctgtc     4500

ttacatcaag ggaggaagac atctgatctt ctgccattca aagaaaaagt gtgacgagct     4560

cgcggcggcc cttcggggta tgggcttgaa ctcagtggca tactacagag ggttggacgt     4620

ctccgtaata ccaactcagg gagacgtagt ggtcgtcgcc accgacgccc tcatgacagg     4680

gtatactggg gactttgact ccgtgatcga ctgcaacgta gcggtcactc aagttgtaga     4740

cctcagttta gaccccacat tcaccataac cacacagatt gtccctcaag acgctgtctc     4800

acgtagccag cgccggggtc gcacgggtag gggaagactg ggcatttata ggtatgtttc     4860

cactggtgag cgagcctcag gaatgtttga cagtgtagtg ctctgtgagt gctacgacgc     4920

aggggccgca tggtatgagc tcacaccatc ggagaccacc gtcaggctca gggcgtattt     4980

caacacgccc ggtttgcctg tgtgccaaga ccatcttgag ttttgggagg cagttttcac     5040

cggcctcaca cacatagatg cccacttcct ttcccaaaca aagcaatcgg gggaaaattt     5100

cgcatactta acagcctacc aggctacagt gtgcgctagg gccaaagccc cccccccgtc     5160

ctgggacgtc atgtggaagt gtttgactcg actcaagccc acactcgtgg gccccacacc     5220

tctcctgtac cgcttgggct ctgttaccaa cgaggtcacc ctcacacatc ccgtgacgaa     5280

atacatcgcc acctgcatgc aagccgacct tgaggtcatg accagcacat gggtcttggc     5340

agggggagtc ttggcggccg tcgcctcgta ttgcctggcg accgggtgtg tttgcatcat     5400

cggccgcttg cacattaacc agcgagccgt cgttgcgccg gacaaggagg tcctctatga     5460

ggcttttgat gagatggagg aatgtgcctc tagggcggct ctcattgaag aggggcagcg     5520

gatagccgag atgctgaagt ccaagatcca aggcttattg cagcaagctt ccaaacaagc     5580

tcaagacata caacccactg tgcaggcttc atggcccaag gtagaacaat tctgggccaa     5640

acacatgtgg aacttcatta gcggcatcca atacctcgca ggactatcaa cactgccagg     5700

gaaccctgca gtagcttcca tgatggcgtt cagtgccgcc ctcaccagtc cgctgtcaac     5760

aagcaccact atccttctca acattttggg gggctggcta gcatcccaaa ttgcaccacc     5820

cgcgggggcc actggcttcg ttgtcagtgg cctagtggga gctgccgtag gcagtatagg     5880

cttaggtaag gtgctagtgg acatcctggc agggtatggt gcgggcattt cgggggctct     5940

cgtcgcattc aagatcatgt ctggcgagaa gccctccatg gaggatgtcg tcaacttgct     6000

gcctggaatt ctgtctccgg gtgccttggt agtgggagtc atctgcgcgg ccattctgcg     6060

ccgacacgtg ggaccggggg aaggcgccgt ccaatggatg aatagactca ttgcctttgc     6120

ttccagagga actcacgtcg cccccaccca ctacgtgacg gagtcggatg cgtcgcagcg     6180

tgtgacccaa ctacttggct cccttaccat aaccagcctg ctcagaagac tccacaactg     6240

gattactgag gactgcccca tcccatgcgg cggctcgtgg ctccgcgatg tgtgggactg     6300

ggtttgcacc atcctaacag actttaaaaa ttggctgacc tccaaattat tcccaaagat     6360

gcccggcctc ccctttgtct cctgtcaaaa ggggtacaag ggcgtgtggg ccggcactgg     6420

catcatgacc acacggtgtc cttgcggcgc caatatctct ggcaatgtcc gcttgggctc     6480

catgagaatc acggggccta agacctgcat gaatatctgg caggggacct ttcctatcaa     6540

ttgttacacg gagggccagt gcgtgccgaa acccgcgcca aactttaagg tcgccatctg     6600

gagggtggcg gcctcagagt acgcggaggt gacgcagcac gggtcatacc actacataac     6660

aggactcacc actgataact tgaaagtccc ctgccaacta ccctctcccg agttcttttc     6720

ctgggtggac ggagtgcaga tccataggtt tgcccccaca ccgaagccgt ttttccggga     6780

tgaggtctcg ttctgcgttg ggcttaattc atttgtcgtc gggtcccagc ttccttgcga     6840

ccctgaaccc gacacagacg tattgatgtc catgctaaca gatccatctc atatcacggc     6900

ggagactgca gcgcggcgtt tagcgcgggg gtcaccccca tccgaggcaa gctcctcggc     6960

gagccagcta tcggcaccat cgctgcgagc cacctgcacc acccacggca aagcctatga     7020

tgtggacatg gtggatgcta acctgttcat ggggggcgat gtgactcgga tagagtctgg     7080

gtccaaagtg gtcgttctgg actctctcga cccaatggtc gaagaaagga gcgaccttga     7140

gccttcgata ccatcagaat acatgctccc caagaagagg ttcccaccag ctttaccggc     7200

ctgggcacgg cctgattaca acccaccgct tgtggaatcg tggaaaaggc cagattacca     7260

accggccact gttgcgggct gtgctctccc tcctcctagg aaaaccccga cgcctccccc     7320

aaggaggcgc cggacagtgg gcctaagtga ggactccata ggagatgccc ttcaacagct     7380

ggccattaag tcctttggcc agcccccccc aagcggcgat tcaggccttt ccacgggggc     7440

gggcgctgcc gattccggca gtcagacgcc tcctgatgag ttggcccttt cggagacagg     7500

ttccatctct tccatgcccc ccctcgaggg ggagcttgga gatccagacc tggagcctga     7560

gcaggtagag ccccaacccc ccccccaggg gggggtggca gctcccggct cggactcggg     7620

gtcctggtct acttgctccg aggaggacga ctccgtcgtg tgctgctcca tgtcatactc     7680

ctggaccggg gctctaataa ctccttgtag tcccgaagag gagaagttac cgattaaccc     7740

cttgagcaac tccctgttgc gatatcacaa caaggtgtac tgtaccacaa caaagagcgc     7800

ctcactaagg gctaaaaagg taacttttga taggatgcaa gtgctcgact cctactacga     7860

ctcagtctta aaggacatta agctagcggc ctccaaggtc accgcaaggc tcctcaccat     7920

ggaggaggct tgccagttaa ccccacccca ttctgcaaga tctaaatatg ggtttggggc     7980

taaggaggtc cgcagcttgt ccgggagggc cgttaaccac atcaagtccg tgtggaagga     8040

cctcctggag gactcagaaa caccaattcc cacaaccatt atggccaaaa atgaggtgtt     8100

ctgcgtggac cccaccaagg ggggcaagaa agcagctcgc cttatcgttt accctgacct     8160

cggcgtcagg gtctgcgaga agatggccct ttatgacatt acacaaaaac ttcctcaggc     8220

ggtgatgggg gcttcttatg gattccagta ttcccccgct cagcgggtag agtttctctt     8280

gaaagcatgg gcggaaaaga aggaccctat gggtttttcg tatgataccc gatgctttga     8340

ctcaaccgtc actgagagag acatcaggac tgaggagtcc atatatcggg cctgctcctt     8400

gcccgaggag gcccacactg ccatacactc gctaactgag agactttacg tgggagggcc     8460

tatgttcaac agcaagggcc aaacctgcgg gtacaggcgt tgccgcgcca gcggggtgct     8520

caccactagc atggggaaca ccatcacatg ctacgtgaaa gccttagcgg cttgtaaagc     8580

tgcagggata atcgcgccca caatgctggt atgcggcgat gacttggttg tcatctcaga     8640

aagccagggg accgaggagg acgagcggaa cctgagagcc ttcacggagg ctatgaccag     8700

gtattctgcc cctcctggtg acccccccag accggagtat gatctggagc tgataacatc     8760

ttgctcctca aatgtgtctg tggcgctggg cccacaaggc cgccgcagat actacctgac     8820

cagagaccct accactccaa tcgcccgggc tgcctgggaa acagttagac actcccctgt     8880

caattcatgg ctgggaaaca tcatccagta cgccccgacc atatgggctc gcatggtcct     8940

gatgacacac ttcttctcca ttctcatggc tcaagacacg ctggaccaga acctcaactt     9000

tgagatgtac ggagcggtgt actccgtgag tcccttggac ctcccagcta taattgaaag     9060

gttacatggg cttgacgctt tttctctgca cacatacact ccccacgaac tgacacgggt     9120

ggcttcagcc ctcagaaaac ttggggcgcc acccctcaga gcgtggaaga gccgggcacg     9180

tgcagtcagg gcgtccctca tctcccgtgg ggggagagcg gccgtttgcg gtcgatatct     9240

cttcaattgg gcggtgaaga ccaagctcaa actcactcca ttgccggaag cgcgcctcct     9300

ggatttatcc agctggttca ccgtcggcgc cggcgggggc ggcatttatc acagcgtgtc     9360

gcgtgcccga ccccgcttat tgctctttgg cctactccta ctttttgtag gggtaggcct     9420

tttcctactc cccgctcggt agagcggcac acattagcta cactccatag ctaactgtcc     9480

cttttttttt tttttttttt tttttttttt tttttttttt tttttttttt ttcttttttt     9540

ctcttttcct tctttcttac cttattttac tttctttcct ggtggctcca tcttagccct     9600

agtcacggct agctgtgaaa ggtccgtgag ccgcatgact gcagagagtg ccgtaactgg     9660

tctctctgca gatcatgt                                                   9678


<210>  36
<211>  9678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  36
acccgcccct aataggggcg acactccgcc atgaatcact cccctgtgag gaactactgt       60

cttcacgcag aaagcgtcta gccatggcgt tagtatgagt gtcgtacagc ctccaggccc      120

ccccctcccg ggagagccat agtggtctgc ggaaccggtg agtacaccgg aattgccggg      180

aagactgggt cctttcttgg ataaacccac tctatgcccg gccatttggg cgtgcccccg      240

caagactgct agccgagtag cgttgggttg cgaaaggcct tgtggtactg cctgataggg      300

tgcttgcgag tgccccggga ggtctcgtag accgtgcacc atgagcacaa atcctaaacc      360

tcaaagaaaa accaaaagaa acaccaaccg tcgcccacaa gacgttaagt ttccgggcgg      420

cggccagatc gttggcggag tatacttgtt gccgcgcagg ggccccaggt tgggtgtgcg      480

cgcgacaagg aagacttcgg agcggtccca gccacgtgga aggcgccagc ccatccctaa      540

agatcggcgc tccactggca aatcctgggg aaaaccagga tacccctggc ccctatacgg      600

gaatgaggga ctcggctggg caggatggct cctgtccccc cgaggttccc gtccctcttg      660

gggccccaat gacccccggc ataggtcgcg caacgtgggt aaggtcatcg ataccctaac      720

gtgcggcttt gccgacctca tggggtacat ccctgtcgtg ggcgccccgc tcggcggcgt      780

cgccagagct ctcgcgcatg gcgtgagagt cctggaggac ggggttaatt ttgcaacagg      840

gaacttaccc ggttgctcct tttctatctt cttgctggcc ctgctgtcct gcatcaccac      900

cccggtctcc gctgccgaag tgaagaacat cagtaccggc tacatggtga ctaacgactg      960

caccaatgac agcattacct ggcagctcca ggctgctgtc ctccacgtcc ccgggtgcgt     1020

cccgtgcgag aaagtgggga atgcatctca gtgctggata ccggtctcac cgaatgtggc     1080

cgtgcagcgg cccggcgccc tcacgcaggg cttgcggacg cacatcgaca tggttgtgat     1140

gtccgccacg ctctgctctg ccctctacgt gggggacctc tgcggtgggg tgatgctcgc     1200

agcccaaatg ttcattgtct cgccgcagca ccactggttt gtccaagact gcaattgctc     1260

catctaccct ggtaccatca ctggacaccg catggcatgg gacatgatga tgaactggtc     1320

gcccacggct accatgatct tggcgtacgc gatgcgtgtc cccgaggtca ttatagacat     1380

cattagcggg gctcattggg gcgtcatgtt cggcttggcc tacttctcta tgcagggagc     1440

gtgggcgaaa gtcgttgtca tccttctgtt ggccgccggg gtggacgcgc gcacccatac     1500

tgttgggggt tctgccgcgc agaccaccgg gcgcctcacc agcttatttg acatgggccc     1560

caggcagaaa atccagctcg ttaacaccaa tggcagctgg cacatcaacc gcaccgccct     1620

gaactgcaat gactccttgc acaccggctt tatcgcgtct ctgttctaca cccacagctt     1680

caactcgtca ggatgtcccg aacgcatgtc cgcctgccgc agtatcgagg ccttccgggt     1740

gggatggggc gccttgcaat atgaggataa tgtcaccaat ccagaggata tgagacccta     1800

ttgctggcac tacccaccaa ggcagtgtgg cgtggtctcc gcgaagactg tgtgtggccc     1860

agtgtactgt ttcaccccca gcccagtggt agtgggcacg accgacaggc ttggagcgcc     1920

cacttacacg tggggggaga atgagacaga tgtcttccta ttgaacagca ctcgaccacc     1980

gctggggtca tggttcggct gcacgtggat gaactcttct ggctacacca agacttgcgg     2040

cgcaccaccc tgccgtacta gagctgactt caacgccagc acggacctgt tgtgccccac     2100

ggactgtttt aggaagcatc ctgataccac ttacctcaaa tgcggctctg ggccctggct     2160

cacgccaagg tgcctgatcg actaccccta caggctctgg cattacccct gcacagttaa     2220

ctataccatc ttcaaaataa ggatgtatgt gggaggggtt gagcacaggc tcacggctgc     2280

atgcaatttc actcgtgggg atcgttgcaa cttggaggac agagacagaa gtcaactgtc     2340

tcctttgttg cactccacca cggaatgggc cattttacct tgctcttact cggacctgcc     2400

cgccttgtcg actggtcttc tccacctcca ccaaaacatc gtggacgtac aattcatgta     2460

tggcctatca cctgccctca caaaatacat cgtccgatgg gagtgggtaa tactcttatt     2520

cctgctctta gcggacgcca gggtttgcgc ctgcttatgg atgctcatct tgttgggcca     2580

ggccgaagca gcactagaga agctggtcat cttgcacgct gcgagcgcag ctagctgcaa     2640

tggcttccta tattttgtca tctttttcgt ggctgcttgg tacatcaagg gtcgggtagt     2700

ccccttagct acctattccc tcactggcct gtggtccttt agcctactgc tcctagcatt     2760

gccccaacag gcttatgctt atgacgcatc tgtgcatggc cagataggag cggctctgct     2820

ggtaatgatc actctcttta ctctcacccc cgggtataag acccttctca gccggttttt     2880

gtggtggttg tgctatcttc tgaccctggg ggaagctatg gtccaggagt gggcaccacc     2940

tatgcaggtg cgcggtggcc gtgatggcat catatgggcc gtcgccatat tctacccagg     3000

tgtggtgttt gacataacca agtggctctt ggcggtgctt gggcctgctt acctcctaaa     3060

aggtgctttg acgcgcgtgc cgtacttcgt cagggctcac gctctactga ggatgtgcac     3120

catggcaagg catctcgcgg ggggcaggta cgtccagatg gcgctactag cccttggcag     3180

gtggactggc acttacatct atgaccacct cacccctatg tcggattggg ctgctagtgg     3240

cctgcgggac ctggcggtcg ccgttgagcc tatcatcttc agtccgatgg agaagaaagt     3300

cattgtctgg ggagcggaga cagctgcttg tggggacatt ttacacggac ttcccgtgtc     3360

cgcccgactt ggtcgggagg tcctccttgg cccagctgat ggctatacct ccaaggggtg     3420

gagtcttctc gcccccatca ctgcttacgc ccagcagaca cgtggccttt tgggcaccat     3480

agtggtgagc atgacggggc gcgacaagac agaacaggct ggggaaattc aggtcctgtc     3540

cacagtcact cagtccttcc tcggaacatc catctcgggg gttttgtgga ctgtctacca     3600

tggagctggc aacaagactc tggccggctc acggggtctg gtcacgcaga tgtactccag     3660

tgctgagggg gacttagtag ggtggcccag cccccctggg actaaatctt tggagccgtg     3720

cacgtgtgga gcggtcgacc tgtacctggt cacgcggaac gctgatgtca tcccggctcg     3780

aagacgcggg gacaaacggg gagcgctact ctccccgaga cctctttcca ccttgaaggg     3840

gtcctcagga ggcccggtgc tatgccccag gggccacgct gtcggagtct tccgggcagc     3900

tgtgtgctct cggggcgtgg ctaagtccat agatttcatc cccgttgaga cactcgacat     3960

cgtcacgcgg tcccccacct ttagtgacaa cagcacacca cctgctgtgc cccagaccta     4020

tcaggtcggg tacttgcatg ccccgactgg cagtggaaag agcaccaaag ttcctgtcgc     4080

atatgctgct caggggtata aagtgctagt gcttaatccc tcagtggctg ccaccctggg     4140

gtttggggcg tacttgtcta aggcacatgg catcaatccc aacattagga ctggagtcag     4200

gactgtgacg accggggcgc ccatcacgta ctccacatat ggcaaattcc tcgccgatgg     4260

gggctgtgcg ggcggcgcct acgacatcat catatgtgat gaatgccatg ccgtggactc     4320

taccaccatc cttggcatcg gaacagtcct tgatcaagca gagacagctg gggtcagact     4380

aactgtgctg gctacagcta cgccccctgg gtcagtgaca accccccacc ccaacataga     4440

ggaggtggcc cttgggcagg agggcgagat ccccttctat gggagggcga ttcccctgtc     4500

ttacatcaag ggaggaagac atctgatctt ctgccattca aagaaaaagt gtgacgagct     4560

cgcggcggcc cttcggggta tgggcttgaa ctcagtggca tactacagag ggttggacgt     4620

ctccgtaata ccaactcagg gagacgtagt ggtcgtcgcc accgacgccc tcatgacagg     4680

gtatactggg gactttgact ccgtgatcga ctgcaacgta gcggtcactc aagttgtaga     4740

cctcagttta gaccccacat tcaccataac cacacagatt gtccctcaag acgctgtctc     4800

acgtagccag cgccggggtc gcacgggtag gggaagactg ggcatttata ggtatgtttc     4860

cactggtgag cgagcctcag gaatgtttga cagtgtagtg ctctgtgagt gctacgacgc     4920

aggggccgca tggtatgagc tcacaccatc ggagaccacc gtcaggctca gggcgtattt     4980

caacacgccc ggtttgcctg tgtgccaaga ccatcttgag ttttgggagg cagttttcac     5040

cggcctcaca cacatagatg cccacttcct ttcccaaaca aagcaatcgg gggaaaattt     5100

cgcatactta acagcctacc aggctacagt gtgcgctagg gccaaagccc cccccccgtc     5160

ctgggacgtc atgtggaagt gtttgactcg actcaagccc acactcgtgg gccccacacc     5220

tctcctgtac cgcttgggct ctgttaccaa cgaggtcacc ctcacacatc ccgtgacgaa     5280

atacatcgcc acctgcatgc aagccgacct tgaggtcatg accagcacat gggtcttggc     5340

agggggagtc ttggcggccg tcgcctcgta ttgcctggcg accgggtgtg tttgcatcat     5400

cggccgcttg cacattaacc agcgagccgt cgttgcgccg gacaaggagg tcctctatga     5460

ggcttttgat gagatggagg aatgtgcctc tagggcggct ctcattgaag aggggcagcg     5520

gatagccgag atgctgaagt ccaagatcca aggcttattg cagcaagctt ccaaacaagc     5580

tcaagacata caacccactg tgcaggcttc atggcccaag gtagaacaat tctgggccaa     5640

acacatgtgg aacttcatta gcggcatcca atacctcgca ggactatcaa cactgccagg     5700

gaaccctgca gtagcttcca tgatggcgtt cagtgccgcc ctcaccagtc cgctgtcaac     5760

aagcaccact atccttctca acattttggg gggctggcta gcatcccaaa ttgcaccacc     5820

cgcgggggcc actggcttcg ttgtcagtgg cctagtggga gctgccgtag gcagtatagg     5880

cttaggtaag gtgctagtgg acatcctggc agggtatggt gcgggcattt cgggggctct     5940

cgtcgcattc aagatcatgt ctggcgagaa gccctccatg gaggatgtcg tcaacttgct     6000

gcctggaatt ctgtctccgg gtgccttggt agtgggagtc atctgcgcgg ccattctgcg     6060

ccgacacgtg ggaccggggg aaggcgccgt ccaatggatg aatagactca ttgcctttgc     6120

ttccagagga agtcacgtcg cccccaccca ctacgtgacg gagtcggatg cgtcgcagcg     6180

tgtgacccaa ctacttggct cccttaccat aaccagcctg ctcagaagac tccacaactg     6240

gattactgag gactgcccca tcccatgcgg cggctcgtgg ctccgcgatg tgtgggactg     6300

ggtttgcacc atcctaacag actttaaaaa ttggctgacc tccaaattat tcccaaagat     6360

gcccggcctc ccctttgtct cctgtcaaaa ggggtacaag ggcgtgtggg ccggcactgg     6420

catcatgacc acacggtgtc cttgcggcgc caatatctct ggcaatgtcc gcttgggctc     6480

catgagaatc acggggccta agacctgcat gaatatctgg caggggacct ttcctatcaa     6540

ttgttacacg gagggccagt gcgtgccgaa acccgcgcca aactttaagg tcgccatctg     6600

gagggtggcg gcctcagagt acgcggaggt gacgcagcac gggtcatacc actacataac     6660

aggactcacc actgataact tgaaagtccc ctgccaacta ccctctcccg agttcttttc     6720

ctgggtggac ggagtgcaga tccataggtt tgcccccaca ccgaagccgt ttttccggga     6780

tgaggtctcg ttctgcgttg ggcttaattc atttgtcgtc gggtcccagc ttccttgcga     6840

ccctgaaccc gacacagacg tattgatgtc catgctaaca gatccatctc atatcacggc     6900

ggagactgca gcgcggcgtt tagcgcgggg gtcaccccca tccgaggcaa gctcctcggc     6960

gagccagcta tcggcaccat cgctgcgagc cacctgcacc acccacggca aagcctatga     7020

tgtggacatg gtggatgcta acctgttcat ggggggcgat gtgactcgga tagagtctgg     7080

gtccaaagtg gtcgttctgg actctctcga cccaatggtc gaagaaagga gcgaccttga     7140

gccttcgata ccatcagaat acatgctccc caagaagagg ttcccaccag ctttaccggc     7200

ctgggcacgg cctgattaca acccaccgct tgtggaatcg tggaaaaggc cagattacca     7260

accggccact gttgcgggct gtgctctccc tcctcctagg aaaaccccga cgcctccccc     7320

aaggaggcgc cggacagtgg gcctaagtga ggactccata ggagatgccc ttcaacagct     7380

ggccattaag tcctttggcc agcccccccc aagcggcgat tcaggccttt ccacgggggc     7440

gggcgctgcc gattccggca gtcagacgcc tcctgatgag ttggcccttt cggagacagg     7500

ttccatctct tccatgcccc ccctcgaggg ggagcttgga gatccagacc tggagcctga     7560

gcaggtagag ccccaacccc ccccccaggg gggggtggca gctcccggct cggactcggg     7620

gtcctggtct acttgctccg aggaggacga ctccgtcgtg tgctgctcca tgtcatactc     7680

ctggaccggg gctctaataa ctccttgtag tcccgaagag gagaagttac cgattaaccc     7740

cttgagcaac tccctgttgc gatatcacaa caaggtgtac tgtaccacaa caaagagcgc     7800

ctcactaagg gctaaaaagg taacttttga taggatgcaa gtgctcgact cctactacga     7860

ctcagtctta aaggacatta agctagcggc ctccaaggtc accgcaaggc tcctcaccat     7920

ggaggaggct tgccagttaa ccccacccca ttctgcaaga tctaaatatg ggtttggggc     7980

taaggaggtc cgcagcttgt ccgggagggc cgttaaccac atcaagtccg tgtggaagga     8040

cctcctggag gactcagaaa caccaattcc cacaaccatt atggccaaaa atgaggtgtt     8100

ctgcgtggac cccaccaagg ggggcaagaa agcagctcgc cttatcgttt accctgacct     8160

cggcgtcagg gtctgcgaga agatggccct ttatgacatt acacaaaaac ttcctcaggc     8220

ggtgatgggg gcttcttatg gattccagta ttcccccgct cagcgggtag agtttctctt     8280

gaaagcatgg gcggaaaaga aggaccctat gggtttttcg tatgataccc gatgctttga     8340

ctcaaccgtc actgagagag acatcaggac tgaggagtcc atatatcggg cctgctcctt     8400

gcccgaggag gcccacactg ccatacactc gctaactgag agactttacg tgggagggcc     8460

tatgttcaac agcaagggcc aaacctgcgg gtacaggcgt tgccgcgcca gcggggtgct     8520

caccactagc atggggaaca ccatcacatg ctacgtgaaa gccttagcgg cttgtaaagc     8580

tgcagggata atcgcgccca caatgctggt atgcggcgat gacttggttg tcatctcaga     8640

aagccagggg accgaggagg acgagcggaa cctgagagcc ttcacggagg ctatgaccag     8700

gtattctgcc cctcctggtg acccccccag accggagtat gatctggagc tgataacatc     8760

ttgctcctca aatgtgtctg tggcgctggg cccacaaggc cgccgcagat actacctgac     8820

cagagaccct accactccaa tcgcccgggc tgcctgggaa acagttagac actcccctgt     8880

caattcatgg ctgggaaaca tcatccagta cgccccgacc atatgggctc gcatggtcct     8940

gatgacacac ttcttctcca ttctcatggc tcaagacacg ctggaccaga acctcaactt     9000

tgagatgtac ggagcggtgt actccgtgag tcccttggac ctcccagcta taattgaaag     9060

gttacatggg cttgacgctt tttctctgca cacatacact ccccacgaac tgacacgggt     9120

ggcttcagcc ctcagaaaac ttggggcgcc acccctcaga gcgtggaaga gccgggcacg     9180

tgcagtcagg gcgtccctca tctcccgtgg ggggagagcg gccgtttgcg gtcgatatct     9240

cttcaattgg gcggtgaaga ccaagctcaa actcactcca ttgccggaag cgcgcctcct     9300

ggatttatcc agctggttca ccgtcggcgc cggcgggggc ggcatttatc acagcgtgtc     9360

gcgtgcccga ccccgcttat tgctctttgg cctactccta ctttttgtag gggtaggcct     9420

tttcctactc cccgctcggt agagcggcac acattagcta cactccatag ctaactgtcc     9480

cttttttttt tttttttttt tttttttttt tttttttttt tttttttttt ttcttttttt     9540

ctcttttcct tctttcttac cttattttac tttctttcct ggtggctcca tcttagccct     9600

agtcacggct agctgtgaaa ggtccgtgag ccgcatgact gcagagagtg ccgtaactgg     9660

tctctctgca gatcatgt                                                   9678


<210>  37
<211>  9678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  37
acccgcccct aataggggcg acactccgcc atgaatcact cccctgtgag gaactactgt       60

cttcacgcag aaagcgtcta gccatggcgt tagtatgagt gtcgtacagc ctccaggccc      120

ccccctcccg ggagagccat agtggtctgc ggaaccggtg agtacaccgg aattgccggg      180

aagactgggt cctttcttgg ataaacccac tctatgcccg gccatttggg cgtgcccccg      240

caagactgct agccgagtag cgttgggttg cgaaaggcct tgtggtactg cctgataggg      300

tgcttgcgag tgccccggga ggtctcgtag accgtgcacc atgagcacaa atcctaaacc      360

tcaaagaaaa accaaaagaa acaccaaccg tcgcccacaa gacgttaagt ttccgggcgg      420

cggccagatc gttggcggag tatacttgtt gccgcgcagg ggccccaggt tgggtgtgcg      480

cgcgacaagg aagacttcgg agcggtccca gccacgtgga aggcgccagc ccatccctaa      540

agatcggcgc tccactggca aatcctgggg aaaaccagga tacccctggc ccctatacgg      600

gaatgaggga ctcggctggg caggatggct cctgtccccc cgaggttccc gtccctcttg      660

gggccccaat gacccccggc ataggtcgcg caacgtgggt aaggtcatcg ataccctaac      720

gtgcggcttt gccgacctca tggggtacat ccctgtcgtg ggcgccccgc tcggcggcgt      780

cgccagagct ctcgcgcatg gcgtgagagt cctggaggac ggggttaatt ttgcaacagg      840

gaacttaccc ggttgctcct tttctatctt cttgctggcc ctgctgtcct gcatcaccac      900

cccggtctcc gctgccgaag tgaagaacat cagtaccggc tacatggtga ctaacgactg      960

caccaatgac agcattacct ggcagctcca ggctgctgtc ctccacgtcc ccgggtgcgt     1020

cccgtgcgag aaagtgggga atgcatctca gtgctggata ccggtctcac cgaatgtggc     1080

cgtgcagcgg cccggcgccc tcacgcaggg cttgcggacg cacatcgaca tggttgtgat     1140

gtccgccacg ctctgctctg ccctctacgt gggggacctc tgcggtgggg tgatgctcgc     1200

agcccaaatg ttcattgtct cgccgcagca ccactggttt gtccaagact gcaattgctc     1260

catctaccct ggtaccatca ctggacaccg catggcatgg gacatgatga tgaactggtc     1320

gcccacggct accatgatct tggcgtacgc gatgcgtgtc cccgaggtca ttatagacat     1380

cattagcggg gctcattggg gcgtcatgtt cggcttggcc tacttctcta tgcagggagc     1440

gtgggcgaaa gtcgttgtca tccttctgtt ggccgccggg gtggacgcgc gcacccatac     1500

tgttgggggt tctgccgcgc agaccaccgg gcgcctcacc agcttatttg acatgggccc     1560

caggcagaaa atccagctcg ttaacaccaa tggcagctgg cacatcaacc gcaccgccct     1620

gaactgcaat gactccttgc acaccggctt tatcgcgtct ctgttctaca cccacagctt     1680

caactcgtca ggatgtcccg aacgcatgtc cgcctgccgc agtatcgagg ccttccgggt     1740

gggatggggc gccttgcaat atgaggataa tgtcaccaat ccagaggata tgagacccta     1800

ttgctggcac tacccaccaa ggcagtgtgg cgtggtctcc gcgaagactg tgtgtggccc     1860

agtgtactgt ttcaccccca gcccagtggt agtgggcacg accgacaggc ttggagcgcc     1920

cacttacacg tggggggaga atgagacaga tgtcttccta ttgaacagca ctcgaccacc     1980

gctggggtca tggttcggct gcacgtggat gaactcttct ggctacacca agacttgcgg     2040

cgcaccaccc tgccgtacta gagctgactt caacgccagc acggacctgt tgtgccccac     2100

ggactgtttt aggaagcatc ctgataccac ttacctcaaa tgcggctctg ggccctggct     2160

cacgccaagg tgcctgatcg actaccccta caggctctgg cattacccct gcacagttaa     2220

ctataccatc ttcaaaataa ggatgtatgt gggaggggtt gagcacaggc tcacggctgc     2280

atgcaatttc actcgtgggg atcgttgcaa cttggaggac agagacagaa gtcaactgtc     2340

tcctttgttg cactccacca cggaatgggc cattttacct tgctcttact cggacctgcc     2400

cgccttgtcg actggtcttc tccacctcca ccaaaacatc gtggacgtac aattcatgta     2460

tggcctatca cctgccctca caaaatacat cgtccgatgg gagtgggtaa tactcttatt     2520

cctgctctta gcggacgcca gggtttgcgc ctgcttatgg atgctcatct tgttgggcca     2580

ggccgaagca gcactagaga agctggtcat cttgcacgct gcgagcgcag ctagctgcaa     2640

tggcttccta tattttgtca tctttttcgt ggctgcttgg tacatcaagg gtcgggtagt     2700

ccccttagct acctattccc tcactggcct gtggtccttt agcctactgc tcctagcatt     2760

gccccaacag gcttatgctt atgacgcatc tgtgcatggc cagataggag cggctctgct     2820

ggtaatgatc actctcttta ctctcacccc cgggtataag acccttctca gccggttttt     2880

gtggtggttg tgctatcttc tgaccctggg ggaagctatg gtccaggagt gggcaccacc     2940

tatgcaggtg cgcggtggcc gtgatggcat catatgggcc gtcgccatat tctacccagg     3000

tgtggtgttt gacataacca agtggctctt ggcggtgctt gggcctgctt acctcctaaa     3060

aggtgctttg acgcgcgtgc cgtacttcgt cagggctcac gctctactga ggatgtgcac     3120

catggcaagg catctcgcgg ggggcaggta cgtccagatg gcgctactag cccttggcag     3180

gtggactggc acttacatct atgaccacct cacccctatg tcggattggg ctgctagtgg     3240

cctgcgggac ctggcggtcg ccgttgagcc tatcatcttc agtccgatgg agaagaaagt     3300

cattgtctgg ggagcggaga cagctgcttg tggggacatt ttacacggac ttcccgtgtc     3360

cgcccgactt ggtcgggagg tcctccttgg cccagctgat ggctatacct ccaaggggtg     3420

gagtcttctc gcccccatca ctgcttacgc ccagcagaca cgtggccttt tgggcaccat     3480

agtggtgagc atgacggggc gcgacaagac agaacaggct ggggaaattc aggtcctgtc     3540

cacagtcact cagtccttcc tcggaacatc catctcgggg gttttgtgga ctgtctacca     3600

tggagctggc aacaagactc tggccggctc acggggtctg gtcacgcaga tgtactccag     3660

tgctgagggg gacttagtag ggtggcccag cccccctggg actaaatctt tggagccgtg     3720

cacgtgtgga gcggtcgacc tgtacctggt cacgcggaac gctgatgtca tcccggctcg     3780

aagacgcggg gacaaacggg gagcgctact ctccccgaga cctctttcca ccttgaaggg     3840

gtcctcagga ggcccggtgc tatgccccag gggccacgct gtcggagtct tccgggcagc     3900

tgtgtgctct cggggcgtgg ctaagtccat agatttcatc cccgttgaga cactcgacat     3960

cgtcacgcgg tcccccacct ttagtgacaa cagcacacca cctgctgtgc cccagaccta     4020

tcaggtcggg tacttgcatg ccccgactgg cagtggaaag agcaccaaag ttcctgtcgc     4080

atatgctgct caggggtata aagtgctagt gcttaatccc tcagtggctg ccaccctggg     4140

gtttggggcg tacttgtcta aggcacatgg catcaatccc aacattagga ctggagtcag     4200

gactgtgacg accggggcgc ccatcacgta ctccacatat ggcaaattcc tcgccgatgg     4260

gggctgtgcg ggcggcgcct acgacatcat catatgtgat gaatgccatg ccgtggactc     4320

taccaccatc cttggcatcg gaacagtcct tgatcaagca gagacagctg gggtcagact     4380

aactgtgctg gctacagcta cgccccctgg gtcagtgaca accccccacc ccaacataga     4440

ggaggtggcc cttgggcagg agggcgagat ccccttctat gggagggcga ttcccctgtc     4500

ttacatcaag ggaggaagac atctgatctt ctgccattca aagaaaaagt gtgacgagct     4560

cgcggcggcc cttcggggta tgggcttgaa ctcagtggca tactacagag ggttggacgt     4620

ctccgtaata ccaactcagg gagacgtagt ggtcgtcgcc accgacgccc tcatgacagg     4680

gtatactggg gactttgact ccgtgatcga ctgcaacgta gcggtcactc aagttgtaga     4740

cctcagttta gaccccacat tcaccataac cacacagatt gtccctcaag acgctgtctc     4800

acgtagccag cgccggggtc gcacgggtag gggaagactg ggcatttata ggtatgtttc     4860

cactggtgag cgagcctcag gaatgtttga cagtgtagtg ctctgtgagt gctacgacgc     4920

aggggccgca tggtatgagc tcacaccatc ggagaccacc gtcaggctca gggcgtattt     4980

caacacgccc ggtttgcctg tgtgccaaga ccatcttgag ttttgggagg cagttttcac     5040

cggcctcaca cacatagatg cccacttcct ttcccaaaca aagcaatcgg gggaaaattt     5100

cgcatactta acagcctacc aggctacagt gtgcgctagg gccaaagccc cccccccgtc     5160

ctgggacgtc atgtggaagt gtttgactcg actcaagccc acactcgtgg gccccacacc     5220

tctcctgtac cgcttgggct ctgttaccaa cgaggtcacc ctcacacatc ccgtgacgaa     5280

atacatcgcc acctgcatgc aagccgacct tgaggtcatg accagcacat gggtcttggc     5340

agggggagtc ttggcggccg tcgcctcgta ttgcctggcg accgggtgtg tttgcatcat     5400

cggccgcttg cacattaacc agcgagccgt cgttgcgccg gacaaggagg tcctctatga     5460

ggcttttgat gagatggagg aatgtgcctc tagggcggct ctcattgaag aggggcagcg     5520

gatagccgag atgctgaagt ccaagatcca aggcttattg cagcaagctt ccaaacaagc     5580

tcaagacata caacccactg tgcaggcttc atggcccaag gtagaacaat tctgggccaa     5640

acacatgtgg aacttcatta gcggcatcca atacctcgca ggactatcaa cactgccagg     5700

gaaccctgca gtagcttcca tgatggcgtt cagtgccgcc ctcaccagtc cgctgtcaac     5760

aagcaccact atccttctca acattttggg gggctggcta gcatcccaaa ttgcaccacc     5820

cgcgggggcc actggcttcg ttgtcagtgg cctagtggga gctgccgtag gcagtatagg     5880

cttaggtaag gtgctagtgg acatcctggc agggtatggt gcgggcattt cgggggctct     5940

cgtcgcattc aagatcatgt ctggcgagaa gccctccatg gaggatgtcg tcaacttgct     6000

gcctggaatt ctgtctccgg gtgccttggt agtgggagtc atctgcgcgg ccattctgcg     6060

ccgacacgtg ggaccggggg aaggcgccgt ccaatggatg aatagactca ttgcctttgc     6120

ttccagagga actcacgtcg cccccaccca ctacgtgacg gagtcggatg cgtcgcagcg     6180

tgtgacccaa ctacttggct cccttaccat aaccagcctg ctcagaagac tccacaactg     6240

gattactgag gactgcccca tcccatgcgg cggctcgtgg ctccgcgatg tgtgggactg     6300

ggtttgcacc atcctaacag actttaaaaa ttggctgacc tccaaattat tcccaaagat     6360

gcccggcctc ccctttgtct cctgtcaaaa ggggtacaag ggcgtgtggg ccggcactgg     6420

catcatgacc acacggtgtc cttgcggcgc caatatctct ggcaatgtcc gcttgggctc     6480

catgagaatc acggggccta agacctgcat gaatatctgg caggggacct ttcctatcaa     6540

ttgttacacg gagggccagt gcgtgccgaa acccgcgcca aactttaagg tcgccatctg     6600

gagggtggcg gcctcagagt acgcggaggt gacgcagcac gggtcatacc actacataac     6660

aggactcacc actgataact tgaaagtccc ctgccaacta ccctctcccg agttcttttc     6720

ctgggtggac ggagtgcaga tccataggtt tgcccccaca ccgaagccgt ttttccggga     6780

tgaggtctcg ttctgcgttg ggcttaattc atttgtcgtc gggtcccagc ttccttgcga     6840

ccctgaaccc gacacagacg tattgatgtc catgctaaca gatccatctc atatcacggc     6900

ggagactgca gcgcggcgtt tagcgcgggg gtcaccccca tccgaggcaa gctcctcggc     6960

gagccagcta tcggcaccat cgctgcgagc cacctgcacc acccacggca aagcctatga     7020

tgtggacatg gtggatgcta acctgttcat ggggggcgat gtgactcgga tagagtctgg     7080

gtccaaagtg gtcgttctgg actctctcga cccaatggtc gaagaaagga gcgaccttga     7140

gccttcgata ccatcagaat acatgctccc caagaagagg ttcccaccag ctttaccggc     7200

ctgggcacgg cctgattaca acccaccgct tgtggaatcg tggaaaaggc cagattacca     7260

accggccact gttgcgggct gtgctctccc tcctcctagg aaaaccccga cgcctccccc     7320

aaggaggcgc cggacagtgg gcctaagtga ggactccata ggagatgccc ttcaacagct     7380

ggccattaag tcctttggcc agcccccccc aagcggcgat tcaggccttt ccacgggggc     7440

gggcgctgcc gattccggca gtcagacgcc tcctgatgag ttggcccttt cggagacagg     7500

ttccatctct tccatgcccc ccctcgaggg ggagcttgga gatccagacc tggagcctga     7560

gcaggtagag ccccaacccc ccccccaggg gggggtggca gctcccggct cggactcggg     7620

gtcctggtct acttgctccg aggaggacga ctccgtcgtg tgctgctcca tgtcatactc     7680

ctggaccggg gctctaataa ctccttgtag tcccgaagag gagaagttac cgattaaccc     7740

cttgagcaac tccctgttgc gatatcacaa caaggtgtac tgtaccacaa caaagagcgc     7800

ctcactaagg gctaaaaagg taacttttga taggatgcaa gtgctcgact cctactacga     7860

ctcagtctta aaggacatta agctagcggc ctccaaggtc accgcaaggc tcctcaccat     7920

ggaggaggct tgccagttaa ccccacccca ttctgcaaga tctaaatatg ggtttggggc     7980

taaggaggtc cgcagcttgt ccgggagggc cgttaaccac atcaagtccg tgtggaagga     8040

cctcctggag gactcagaaa caccaattcc cacaaccatt atggccaaaa atgaggtgtt     8100

ctgcgtggac cccaccaagg ggggcaagaa agcagctcgc cttatcgttt accctgacct     8160

cggcgtcagg gtctgcgaga agatggccct ttatgacatt acacaaaaac ttcctcaggc     8220

ggtgatgggg gcttcttatg gattccagta ttcccccgct cagcgggtag agtttctctt     8280

gaaagcatgg gcggaaaaga aggaccctat gggtttttcg tatgataccc gatgctttga     8340

ctcaaccgtc actgagagag acatcaggac tgaggagtcc atatatcggg cctgctcctt     8400

gcccgaggag gcccacactg ccatacactc gctaactgag agactttacg tgggagggcc     8460

tatgttcaac agcaagggcc aaacctgcgg gtacaggcgt tgccgcgcca gcggggtgct     8520

caccactagc atggggaaca ccatcacatg ctacgtgaaa gccttagcgg cttgtaaagc     8580

tgcagggata atcgcgccca caatgctggt atgcggcgat gacttggttg tcatctcaga     8640

aagccagggg accgaggagg acgagcggaa cctgagagcc ttcacggagg ctatgaccag     8700

gtattctgcc cctcctggtg acccccccag accggagtat gatctggagc tgataacatc     8760

ttgctcctca aatgtgtctg tggcgctggg cccacaaggc cgccgcagat actacctgac     8820

cagagaccct accactccaa tcgcccgggc tgcctgggaa acagttagac actcccctgt     8880

caattcatgg ctgggaaaca tcatccagta cgccccgacc atatgggctc gcatggtcct     8940

gatgacacac ttcttctcca ttctcatggc tcaagacacg ctggaccaga acctcaactt     9000

tgagatgtac ggagcggtgt actccgtgag tcccttggac ctcccagcta taattgaaag     9060

gttacatggg cttgacgctt tttctctgca cacatacact ccccacgaac tgacacgggt     9120

ggcttcagcc ctcagaaaac ttggggcgcc acccctcaga gcgtggaaga gccgggcacg     9180

tgcagtcagg gcgtccctca tctcccgtgg ggggagagcg gccgtttgcg gtcgatatct     9240

cttcaattgg gcggtgaaga ccaagctcaa actcactcca ttgccggaag cgcgcctcct     9300

ggatttatcc agctggttca ccgtcggcgc cggcgggggc ggcatttatc acagcgtgtc     9360

gcgtgcccga ccccgcttat tgctctttgg cctactccta ctttttgtag gggtaggcct     9420

tttcctactc cccgctcggt agagcggcac acattagcta cactccatag ctaactgtcc     9480

cttttttttt tttttttttt tttttttttt tttttttttt tttttttttt ttcttttttt     9540

ctcttttcct tctttcttac cttattttac tttctttcct ggtggctcca tcttagccct     9600

agtcacggct agctgtgaaa ggtccgtgag ccgcatgact gcagagagtg ccgtaactgg     9660

tctctctgca gatcatgt                                                   9678


<210>  38
<211>  9678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  38
acccgcccct aataggggcg acactccgcc atgaatcact cccctgtgag gaactactgt       60

cttcacgcag aaagcgtcta gccatggcgt tagtatgagt gtcgtacagc ctccaggccc      120

ccccctcccg ggagagccat agtggtctgc ggaaccggtg agtacaccgg aattgccggg      180

aagactgggt cctttcttgg ataaacccac tctatgcccg gccatttggg cgtgcccccg      240

caagactgct agccgagtag cgttgggttg cgaaaggcct tgtggtactg cctgataggg      300

tgcttgcgag tgccccggga ggtctcgtag accgtgcacc atgagcacaa atcctaaacc      360

tcaaagaaaa accaaaagaa acaccaaccg tcgcccacaa gacgttaagt ttccgggcgg      420

cggccagatc gttggcggag tatacttgtt gccgcgcagg ggccccaggt tgggtgtgcg      480

cgcgacaagg aagacttcgg agcggtccca gccacgtgga aggcgccagc ccatccctaa      540

agatcggcgc tccactggca aatcctgggg aaaaccagga tacccctggc ccctatacgg      600

gaatgaggga ctcggctggg caggatggct cctgtccccc cgaggttccc gtccctcttg      660

gggccccaat gacccccggc ataggtcgcg caacgtgggt aaggtcatcg ataccctaac      720

gtgcggcttt gccgacctca tggggtacat ccctgtcgtg ggcgccccgc tcggcggcgt      780

cgccagagct ctcgcgcatg gcgtgagagt cctggaggac ggggttaatt ttgcaacagg      840

gaacttaccc ggttgctcct tttctatctt cttgctggcc ctgctgtcct gcatcaccac      900

cccggtctcc gctgccgaag tgaagaacat cagtaccggc tacatggtga ctaacgactg      960

caccaatgac agcattacct ggcagctcca ggctgctgtc ctccacgtcc ccgggtgcgt     1020

cccgtgcgag aaagtgggga atgcatctca gtgctggata ccggtctcac cgaatgtggc     1080

cgtgcagcgg cccggcgccc tcacgcaggg cttgcggacg cacatcgaca tggttgtgat     1140

gtccgccacg ctctgctctg ccctctacgt gggggacctc tgcggtgggg tgatgctcgc     1200

agcccaaatg ttcattgtct cgccgcagca ccactggttt gtccaagact gcaattgctc     1260

catctaccct ggtaccatca ctggacaccg catggcatgg gacatgatga tgaactggtc     1320

gcccacggct accatgatct tggcgtacgc gatgcgtgtc cccgaggtca ttatagacat     1380

cattagcggg gctcattggg gcgtcatgtt cggcttggcc tacttctcta tgcagggagc     1440

gtgggcgaaa gtcgttgtca tccttctgtt ggccgccggg gtggacgcgc gcacccatac     1500

tgttgggggt tctgccgcgc agaccaccgg gcgcctcacc agcttatttg acatgggccc     1560

caggcagaaa atccagctcg ttaacaccaa tggcagctgg cacatcaacc gcaccgccct     1620

gaactgcaat gactccttgc acaccggctt tatcgcgtct ctgttctaca cccacagctt     1680

caactcgtca ggatgtcccg aacgcatgtc cgcctgccgc agtatcgagg ccttccgggt     1740

gggatggggc gccttgcaat atgaggataa tgtcaccaat ccagaggata tgagacccta     1800

ttgctggcac tacccaccaa ggcagtgtgg cgtggtctcc gcgaagactg tgtgtggccc     1860

agtgtactgt ttcaccccca gcccagtggt agtgggcacg accgacaggc ttggagcgcc     1920

cacttacacg tggggggaga atgagacaga tgtcttccta ttgaacagca ctcgaccacc     1980

gctggggtca tggttcggct gcacgtggat gaactcttct ggctacacca agacttgcgg     2040

cgcaccaccc tgccgtacta gagctgactt caacgccagc acggacctgt tgtgccccac     2100

ggactgtttt aggaagcatc ctgataccac ttacctcaaa tgcggctctg ggccctggct     2160

cacgccaagg tgcctgatcg actaccccta caggctctgg cattacccct gcacagttaa     2220

ctataccatc ttcaaaataa ggatgtatgt gggaggggtt gagcacaggc tcacggctgc     2280

atgcaatttc actcgtgggg atcgttgcaa cttggaggac agagacagaa gtcaactgtc     2340

tcctttgttg cactccacca cggaatgggc cattttacct tgctcttact cggacctgcc     2400

cgccttgtcg actggtcttc tccacctcca ccaaaacatc gtggacgtac aattcatgta     2460

tggcctatca cctgccctca caaaatacat cgtccgatgg gagtgggtaa tactcttatt     2520

cctgctctta gcggacgcca gggtttgcgc ctgcttatgg atgctcatct tgttgggcca     2580

ggccgaagca gcactagaga agctggtcat cttgcacgct gcgagcgcag ctagctgcaa     2640

tggcttccta tattttgtca tcttttccgt ggctgcttgg tacatcaagg gtcgggtagt     2700

ccccttagct acctattccc tcactggcct gtggtccttt agcctactgc tcctagcatt     2760

gccccaacag gcttatgctt atgacgcatc tgtgcatggc cagataggag cggctctgct     2820

ggtaatgatc actctcttta ctctcacccc cgggtataag acccttctca gccggttttt     2880

gtggtggttg tgctatcttc tgaccctggg ggaagctatg gtccaggagt gggcaccacc     2940

tatgcaggtg cgcggtggcc gtgatggcat catatgggcc gtcgccatat tctacccagg     3000

tgtggtgttt gacataacca agtggctctt ggcggtgctt gggcctgctt acctcctaaa     3060

aggtgctttg acgcgcgtgc cgtacttcgt cagggctcac gctctactga ggatgtgcac     3120

catggcaagg catctcgcgg ggggcaggta cgtccagatg gcgctactag cccttggcag     3180

gtggactggc acttacatct atgaccacct cacccctatg tcggattggg ctgctagtgg     3240

cctgcgggac ctggcggtcg ccgttgagcc tatcatcttc agtccgatgg agaagaaagt     3300

cattgtctgg ggagcggaga cagctgcttg tggggacatt ttacacggac ttcccgtgtc     3360

cgcccgactt ggtcgggagg tcctccttgg cccagctgat ggctatacct ccaaggggtg     3420

gagtcttctc gcccccatca ctgcttacgc ccagcagaca cgtggccttt tgggcaccat     3480

agtggtgagc atgacggggc gcgacaagac agaacaggct ggggaaattc aggtcctgtc     3540

cacagtcact cagtccttcc tcggaacatc catctcgggg gttttgtgga ctgtctacca     3600

tggagctggc aacaagactc tggccggctc acggggtctg gtcacgcaga tgtactccag     3660

tgctgagggg gacttagtag ggtggcccag cccccctggg actaaatctt tggagccgtg     3720

cacgtgtgga gcggtcgacc tgtacctggt cacgcggaac gctgatgtca tcccggctcg     3780

aagacgcggg gacaaacggg gagcgctact ctccccgaga cctctttcca ccttgaaggg     3840

gtcctcagga ggcccggtgc tatgccccag gggccacgct gtcggagtct tccgggcagc     3900

tgtgtgctct cggggcgtgg ctaagtccat agatttcatc cccgttgaga cactcgacat     3960

cgtcacgcgg tcccccacct ttagtgacaa cagcacacca cctgctgtgc cccagaccta     4020

tcaggtcggg tacttgcatg ccccgactgg cagtggaaag agcaccaaag ttcctgtcgc     4080

atatgctgct caggggtata aagtgctagt gcttaatccc tcagtggctg ccaccctggg     4140

gtttggggcg tacttgtcta aggcacatgg catcaatccc aacattagga ctggagtcag     4200

gactgtgacg accggggcgc ccatcacgta ctccacatat ggcaaattcc tcgccgatgg     4260

gggctgtgcg ggcggcgcct acgacatcat catatgtgat gaatgccatg ccgtggactc     4320

taccaccatc cttggcatcg gaacagtcct tgatcaagca gagacagctg gggtcagact     4380

aactgtgctg gctacagcta cgccccctgg gtcagtgaca accccccacc ccaacataga     4440

ggaggtggcc cttgggcagg agggcgagat ccccttctat gggagggcga ttcccctgtc     4500

ttacatcaag ggaggaagac atctgatctt ctgccattca aagaaaaagt gtgacgagct     4560

cgcggcggcc cttcggggta tgggcttgaa ctcagtggca tactacagag ggttggacgt     4620

ctccgtaata ccaactcagg gagacgtagt ggtcgtcgcc accgacgccc tcatgacagg     4680

gtatactggg gactttgact ccgtgatcga ctgcaacgta gcggtcactc aagttgtaga     4740

cctcagttta gaccccacat tcaccataac cacacagatt gtccctcaag acgctgtctc     4800

acgtagccag cgccggggtc gcacgggtag gggaagactg ggcatttata ggtatgtttc     4860

cactggtgag cgagcctcag gaatgtttga cagtgtagtg ctctgtgagt gctacgacgc     4920

aggggccgca tggtatgagc tcacaccatc ggagaccacc gtcaggctca gggcgtattt     4980

caacacgccc ggtttgcctg tgtgccaaga ccatcttgag ttttgggagg cagttttcac     5040

cggcctcaca cacatagatg cccacttcct ttcccaaaca aagcaatcgg gggaaaattt     5100

cgcatactta acagcctacc aggctacagt gtgcgctagg gccaaagccc cccccccgtc     5160

ctgggacgtc atgtggaagt gtttgactcg actcaagccc acactcgtgg gccccacacc     5220

tctcctgtac cgcttgggct ctgttaccaa cgaggtcacc ctcacacatc ccgtgacgaa     5280

atacatcgcc acctgcatgc aagccgacct tgaggtcatg accagcacat gggtcttggc     5340

agggggagtc ttggcggccg tcgcctcgta ttgcctggcg accgggtgtg tttgcatcat     5400

cggccgcttg cacattaacc agcgagccgt cgttgcgccg gacaaggagg tcctctatga     5460

ggcttttgat gagatggagg aatgtgcctc tagggcggct ctcattgaag aggggcagcg     5520

gatagccgag atgctgaagt ccaagatcca aggcttattg cagcaagctt ccaaacaagc     5580

tcaagacata caacccactg tgcaggcttc atggcccaag gtagaacaat tctgggccaa     5640

acacatgtgg aacttcatta gcggcatcca atacctcgca ggactatcaa cactgccagg     5700

gaaccctgca gtagcttcca tgatggcgtt cagtgccgcc ctcaccagtc cgctgtcaac     5760

aagcaccact atccttctca acattttggg gggctggcta gcatcccaaa ttgcaccacc     5820

cgcgggggcc actggcttcg ttgtcagtgg cctagtggga gctgccgtag gcagtatagg     5880

cttaggtaag gtgctagtgg acatcctggc agggtatggt gcgggcattt cgggggctct     5940

cgtcgcattc aagatcatgt ctggcgagaa gccctccatg gaggatgtcg tcaacttgct     6000

gcctggaatt ctgtctccgg gtgccttggt agtgggagtc atctgcgcgg ccattctgcg     6060

ccgacacgtg ggaccggggg aaggcgccgt ccaatggatg aatagactca ttgcctttgc     6120

ttccagagga agtcacgtcg cccccaccca ctacgtgacg gagtcggatg cgtcgcagcg     6180

tgtgacccaa ctacttggct cccttaccat aaccagcctg ctcagaagac tccacaactg     6240

gattactgag gactgcccca tcccatgcgg cggctcgtgg ctccgcgatg tgtgggactg     6300

ggtttgcacc atcctaacag actttaaaaa ttggctgacc tccaaattat tcccaaagat     6360

gcccggcctc ccctttgtct cctgtcaaaa ggggtacaag ggcgtgtggg ccggcactgg     6420

catcatgacc acacggtgtc cttgcggcgc caatatctct ggcaatgtcc gcttgggctc     6480

catgagaatc acggggccta agacctgcat gaatatctgg caggggacct ttcctatcaa     6540

ttgttacacg gagggccagt gcgtgccgaa acccgcgcca aactttaagg tcgccatctg     6600

gagggtggcg gcctcagagt acgcggaggt gacgcagcac gggtcatacc actacataac     6660

aggactcacc actgataact tgaaagtccc ctgccaacta ccctctcccg agttcttttc     6720

ctgggtggac ggagtgcaga tccataggtt tgcccccaca ccgaagccgt ttttccggga     6780

tgaggtctcg ttctgcgttg ggcttaattc atttgtcgtc gggtcccagc ttccttgcga     6840

ccctgaaccc gacacagacg tattgatgtc catgctaaca gatccatctc atatcacggc     6900

ggagactgca gcgcggcgtt tagcgcgggg gtcaccccca tccgaggcaa gctcctcggc     6960

gagccagcta tcggcaccat cgctgcgagc cacctgcacc acccacggca aagcctatga     7020

tgtggacatg gtggatgcta acctgttcat ggggggcgat gtgactcgga tagagtctgg     7080

gtccaaagtg gtcgttctgg actctctcga cccaatggtc gaagaaagga gcgaccttga     7140

gccttcgata ccatcagaat acatgctccc caagaagagg ttcccaccag ctttaccggc     7200

ctgggcacgg cctgattaca acccaccgct tgtggaatcg tggaaaaggc cagattacca     7260

accggccact gttgcgggct gtgctctccc tcctcctagg aaaaccccga cgcctccccc     7320

aaggaggcgc cggacagtgg gcctaagtga ggactccata ggagatgccc ttcaacagct     7380

ggccattaag tcctttggcc agcccccccc aagcggcgat tcaggccttt ccacgggggc     7440

gggcgctgcc gattccggca gtcagacgcc tcctgatgag ttggcccttt cggagacagg     7500

ttccatctct tccatgcccc ccctcgaggg ggagcttgga gatccagacc tggagcctga     7560

gcaggtagag ccccaacccc ccccccaggg gggggtggca gctcccggct cggactcggg     7620

gtcctggtct acttgctccg aggaggacga ctccgtcgtg tgctgctcca tgtcatactc     7680

ctggaccggg gctctaataa ctccttgtag tcccgaagag gagaagttac cgattaaccc     7740

cttgagcaac tccctgttgc gatatcacaa caaggtgtac tgtaccacaa caaagagcgc     7800

ctcactaagg gctaaaaagg taacttttga taggatgcaa gtgctcgact cctactacga     7860

ctcagtctta aaggacatta agctagcggc ctccaaggtc accgcaaggc tcctcaccat     7920

ggaggaggct tgccagttaa ccccacccca ttctgcaaga tctaaatatg ggtttggggc     7980

taaggaggtc cgcagcttgt ccgggagggc cgttaaccac atcaagtccg tgtggaagga     8040

cctcctggag gactcagaaa caccaattcc cacaaccatt atggccaaaa atgaggtgtt     8100

ctgcgtggac cccaccaagg ggggcaagaa agcagctcgc cttatcgttt accctgacct     8160

cggcgtcagg gtctgcgaga agatggccct ttatgacatt acacaaaaac ttcctcaggc     8220

ggtgatgggg gcttcttatg gattccagta ttcccccgct cagcgggtag agtttctctt     8280

gaaagcatgg gcggaaaaga aggaccctat gggtttttcg tatgataccc gatgctttga     8340

ctcaaccgtc actgagagag acatcaggac tgaggagtcc atatatcggg cctgctcctt     8400

gcccgaggag gcccacactg ccatacactc gctaactgag agactttacg tgggagggcc     8460

tatgttcaac agcaagggcc aaacctgcgg gtacaggcgt tgccgcgcca gcggggtgct     8520

caccactagc atggggaaca ccatcacatg ctacgtgaaa gccttagcgg cttgtaaagc     8580

tgcagggata atcgcgccca caatgctggt atgcggcgat gacttggttg tcatctcaga     8640

aagccagggg accgaggagg acgagcggaa cctgagagcc ttcacggagg ctatgaccag     8700

gtattctgcc cctcctggtg acccccccag accggagtat gatctggagc tgataacatc     8760

ttgctcctca aatgtgtctg tggcgctggg cccacaaggc cgccgcagat actacctgac     8820

cagagaccct accactccaa tcgcccgggc tgcctgggaa acagttagac actcccctgt     8880

caattcatgg ctgggaaaca tcatccagta cgccccgacc atatgggctc gcatggtcct     8940

gatgacacac ttcttctcca ttctcatggc tcaagacacg ctggaccaga acctcaactt     9000

tgagatgtac ggagcggtgt actccgtgag tcccttggac ctcccagcta taattgaaag     9060

gttacatggg cttgacgctt tttctctgca cacatacact ccccacgaac tgacacgggt     9120

ggcttcagcc ctcagaaaac ttggggcgcc acccctcaga gcgtggaaga gccgggcacg     9180

tgcagtcagg gcgtccctca tctcccgtgg ggggagagcg gccgtttgcg gtcgatatct     9240

cttcaattgg gcggtgaaga ccaagctcaa actcactcca ttgccggaag cgcgcctcct     9300

ggatttatcc agctggttca ccgtcggcgc cggcgggggc ggcatttatc acagcgtgtc     9360

gcgtgcccga ccccgcttat tgctctttgg cctactccta ctttttgtag gggtaggcct     9420

tttcctactc cccgctcggt agagcggcac acattagcta cactccatag ctaactgtcc     9480

cttttttttt tttttttttt tttttttttt tttttttttt tttttttttt ttcttttttt     9540

ctcttttcct tctttcttac cttattttac tttctttcct ggtggctcca tcttagccct     9600

agtcacggct agctgtgaaa ggtccgtgag ccgcatgact gcagagagtg ccgtaactgg     9660

tctctctgca gatcatgt                                                   9678


<210>  39
<211>  9678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  39
acccgcccct aataggggcg acactccgcc atgaatcact cccctgtgag gaactactgt       60

cttcacgcag aaagcgtcta gccatggcgt tagtatgagt gtcgtacagc ctccaggccc      120

ccccctcccg ggagagccat agtggtctgc ggaaccggtg agtacaccgg aattgccggg      180

aagactgggt cctttcttgg ataaacccac tctatgcccg gccatttggg cgtgcccccg      240

caagactgct agccgagtag cgttgggttg cgaaaggcct tgtggtactg cctgataggg      300

tgcttgcgag tgccccggga ggtctcgtag accgtgcacc atgagcacaa atcctaaacc      360

tcaaagaaaa accaaaagaa acaccaaccg tcgcccacaa gacgttaagt ttccgggcgg      420

cggccagatc gttggcggag tatacttgtt gccgcgcagg ggccccaggt tgggtgtgcg      480

cgcgacaagg aagacttcgg agcggtccca gccacgtgga aggcgccagc ccatccctaa      540

agatcggcgc tccactggca aatcctgggg aaaaccagga tacccctggc ccctatacgg      600

gaatgaggga ctcggctggg caggatggct cctgtccccc cgaggttccc gtccctcttg      660

gggccccaat gacccccggc ataggtcgcg caacgtgggt aaggtcatcg ataccctaac      720

gtgcggcttt gccgacctca tggggtacat ccctgtcgtg ggcgccccgc tcggcggcgt      780

cgccagagct ctcgcgcatg gcgtgagagt cctggaggac ggggttaatt ttgcaacagg      840

gaacttaccc ggttgctcct tttctatctt cttgctggcc ctgctgtcct gcatcaccac      900

cccggtctcc gctgccgaag tgaagaacat cagtaccggc tacatggtga ctaacgactg      960

caccaatgac agcattacct ggcagctcca ggctgctgtc ctccacgtcc ccgggtgcgt     1020

cccgtgcgag aaagtgggga atgcatctca gtgctggata ccggtctcac cgaatgtggc     1080

cgtgcagcgg cccggcgccc tcacgcaggg cttgcggacg cacatcgaca tggttgtgat     1140

gtccgccacg ctctgctctg ccctctacgt gggggacctc tgcggtgggg tgatgctcgc     1200

agcccaaatg ttcattgtct cgccgcagca ccactggttt gtccaagact gcaattgctc     1260

catctaccct ggtaccatca ctggacaccg catggcatgg gacatgatga tgaactggtc     1320

gcccacggct accatgatct tggcgtacgc gatgcgtgtc cccgaggtca ttatagacat     1380

cattagcggg gctcattggg gcgtcatgtt cggcttggcc tacttctcta tgcagggagc     1440

gtgggcgaaa gtcgttgtca tccttctgtt ggccgccggg gtggacgcgc gcacccatac     1500

tgttgggggt tctgccgcgc agaccaccgg gcgcctcacc agcttatttg acatgggccc     1560

caggcagaaa atccagctcg ttaacaccaa tggcagctgg cacatcaacc gcaccgccct     1620

gaactgcaat gactccttgc acaccggctt tatcgcgtct ctgttctaca cccacagctt     1680

caactcgtca ggatgtcccg aacgcatgtc cgcctgccgc agtatcgagg ccttccgggt     1740

gggatggggc gccttgcaat atgaggataa tgtcaccaat ccagaggata tgagacccta     1800

ttgctggcac tacccaccaa ggcagtgtgg cgtggtctcc gcgaagactg tgtgtggccc     1860

agtgtactgt ttcaccccca gcccagtggt agtgggcacg accgacaggc ttggagcgcc     1920

cacttacacg tggggggaga atgagacaga tgtcttccta ttgaacagca ctcgaccacc     1980

gctggggtca tggttcggct gcacgtggat gaactcttct ggctacacca agacttgcgg     2040

cgcaccaccc tgccgtacta gagctgactt caacgccagc acggacctgt tgtgccccac     2100

ggactgtttt aggaagcatc ctgataccac ttacctcaaa tgcggctctg ggccctggct     2160

cacgccaagg tgcctgatcg actaccccta caggctctgg cattacccct gcacagttaa     2220

ctataccatc ttcaaaataa ggatgtatgt gggaggggtt gagcacaggc tcacggctgc     2280

atgcaatttc actcgtgggg atcgttgcaa cttggaggac agagacagaa gtcaactgtc     2340

tcctttgttg cactccacca cggaatgggc cattttacct tgctcttact cggacctgcc     2400

cgccttgtcg actggtcttc tccacctcca ccaaaacatc gtggacgtac aattcatgta     2460

tggcctatca cctgccctca caaaatacat cgtccgatgg gagtgggtaa tactcttatt     2520

cctgctctta gcggacgcca gggtttgcgc ctgcttatgg atgctcatct tgttgggcca     2580

ggccgaagca gcactagaga agctggtcat cttgcacgct gcgagcgcag ctagctgcaa     2640

tggcttccta tattttgtca tcttttccgt ggctgcttgg tacatcaagg gtcgggtagt     2700

ccccttagct acctattccc tcactggcct gtggtccttt agcctactgc tcctagcatt     2760

gccccaacag gcttatgctt atgacgcatc tgtgcatggc cagataggag cggctctgct     2820

ggtaatgatc actctcttta ctctcacccc cgggtataag acccttctca gccggttttt     2880

gtggtggttg tgctatcttc tgaccctggg ggaagctatg gtccaggagt gggcaccacc     2940

tatgcaggtg cgcggtggcc gtgatggcat catatgggcc gtcgccatat tctacccagg     3000

tgtggtgttt gacataacca agtggctctt ggcggtgctt gggcctgctt acctcctaaa     3060

aggtgctttg acgcgcgtgc cgtacttcgt cagggctcac gctctactga ggatgtgcac     3120

catggcaagg catctcgcgg ggggcaggta cgtccagatg gcgctactag cccttggcag     3180

gtggactggc acttacatct atgaccacct cacccctatg tcggattggg ctgctagtgg     3240

cctgcgggac ctggcggtcg ccgttgagcc tatcatcttc agtccgatgg agaagaaagt     3300

cattgtctgg ggagcggaga cagctgcttg tggggacatt ttacacggac ttcccgtgtc     3360

cgcccgactt ggtcgggagg tcctccttgg cccagctgat ggctatacct ccaaggggtg     3420

gagtcttctc gcccccatca ctgcttacgc ccagcagaca cgtggccttt tgggcaccat     3480

agtggtgagc atgacggggc gcgacaagac agaacaggct ggggaaattc aggtcctgtc     3540

cacagtcact cagtccttcc tcggaacatc catctcgggg gttttgtgga ctgtctacca     3600

tggagctggc aacaagactc tggccggctc acggggtctg gtcacgcaga tgtactccag     3660

tgctgagggg gacttagtag ggtggcccag cccccctggg actaaatctt tggagccgtg     3720

cacgtgtgga gcggtcgacc tgtacctggt cacgcggaac gctgatgtca tcccggctcg     3780

aagacgcggg gacaaacggg gagcgctact ctccccgaga cctctttcca ccttgaaggg     3840

gtcctcagga ggcccggtgc tatgccccag gggccacgct gtcggagtct tccgggcagc     3900

tgtgtgctct cggggcgtgg ctaagtccat agatttcatc cccgttgaga cactcgacat     3960

cgtcacgcgg tcccccacct ttagtgacaa cagcacacca cctgctgtgc cccagaccta     4020

tcaggtcggg tacttgcatg ccccgactgg cagtggaaag agcaccaaag ttcctgtcgc     4080

atatgctgct caggggtata aagtgctagt gcttaatccc tcagtggctg ccaccctggg     4140

gtttggggcg tacttgtcta aggcacatgg catcaatccc aacattagga ctggagtcag     4200

gactgtgacg accggggcgc ccatcacgta ctccacatat ggcaaattcc tcgccgatgg     4260

gggctgtgcg ggcggcgcct acgacatcat catatgtgat gaatgccatg ccgtggactc     4320

taccaccatc cttggcatcg gaacagtcct tgatcaagca gagacagctg gggtcagact     4380

aactgtgctg gctacagcta cgccccctgg gtcagtgaca accccccacc ccaacataga     4440

ggaggtggcc cttgggcagg agggcgagat ccccttctat gggagggcga ttcccctgtc     4500

ttacatcaag ggaggaagac atctgatctt ctgccattca aagaaaaagt gtgacgagct     4560

cgcggcggcc cttcggggta tgggcttgaa ctcagtggca tactacagag ggttggacgt     4620

ctccgtaata ccaactcagg gagacgtagt ggtcgtcgcc accgacgccc tcatgacagg     4680

gtatactggg gactttgact ccgtgatcga ctgcaacgta gcggtcactc aagttgtaga     4740

cctcagttta gaccccacat tcaccataac cacacagatt gtccctcaag acgctgtctc     4800

acgtagccag cgccggggtc gcacgggtag gggaagactg ggcatttata ggtatgtttc     4860

cactggtgag cgagcctcag gaatgtttga cagtgtagtg ctctgtgagt gctacgacgc     4920

aggggccgca tggtatgagc tcacaccatc ggagaccacc gtcaggctca gggcgtattt     4980

caacacgccc ggtttgcctg tgtgccaaga ccatcttgag ttttgggagg cagttttcac     5040

cggcctcaca cacatagatg cccacttcct ttcccaaaca aagcaatcgg gggaaaattt     5100

cgcatactta acagcctacc aggctacagt gtgcgctagg gccaaagccc cccccccgtc     5160

ctgggacgtc atgtggaagt gtttgactcg actcaagccc acactcgtgg gccccacacc     5220

tctcctgtac cgcttgggct ctgttaccaa cgaggtcacc ctcacacatc ccgtgacgaa     5280

atacatcgcc acctgcatgc aagccgacct tgaggtcatg accagcacat gggtcttggc     5340

agggggagtc ttggcggccg tcgcctcgta ttgcctggcg accgggtgtg tttgcatcat     5400

cggccgcttg cacattaacc agcgagccgt cgttgcgccg gacaaggagg tcctctatga     5460

ggcttttgat gagatggagg aatgtgcctc tagggcggct ctcattgaag aggggcagcg     5520

gatagccgag atgctgaagt ccaagatcca aggcttattg cagcaagctt ccaaacaagc     5580

tcaagacata caacccactg tgcaggcttc atggcccaag gtagaacaat tctgggccaa     5640

acacatgtgg aacttcatta gcggcatcca atacctcgca ggactatcaa cactgccagg     5700

gaaccctgca gtagcttcca tgatggcgtt cagtgccgcc ctcaccagtc cgctgtcaac     5760

aagcaccact atccttctca acattttggg gggctggcta gcatcccaaa ttgcaccacc     5820

cgcgggggcc actggcttcg ttgtcagtgg cctagtggga gctgccgtag gcagtatagg     5880

cttaggtaag gtgctagtgg acatcctggc agggtatggt gcgggcattt cgggggctct     5940

cgtcgcattc aagatcatgt ctggcgagaa gccctccatg gaggatgtcg tcaacttgct     6000

gcctggaatt ctgtctccgg gtgccttggt agtgggagtc atctgcgcgg ccattctgcg     6060

ccgacacgtg ggaccggggg aaggcgccgt ccaatggatg aatagactca ttgcctttgc     6120

ttccagagga actcacgtcg cccccaccca ctacgtgacg gagtcggatg cgtcgcagcg     6180

tgtgacccaa ctacttggct cccttaccat aaccagcctg ctcagaagac tccacaactg     6240

gattactgag gactgcccca tcccatgcgg cggctcgtgg ctccgcgatg tgtgggactg     6300

ggtttgcacc atcctaacag actttaaaaa ttggctgacc tccaaattat tcccaaagat     6360

gcccggcctc ccctttgtct cctgtcaaaa ggggtacaag ggcgtgtggg ccggcactgg     6420

catcatgacc acacggtgtc cttgcggcgc caatatctct ggcaatgtcc gcttgggctc     6480

catgagaatc acggggccta agacctgcat gaatatctgg caggggacct ttcctatcaa     6540

ttgttacacg gagggccagt gcgtgccgaa acccgcgcca aactttaagg tcgccatctg     6600

gagggtggcg gcctcagagt acgcggaggt gacgcagcac gggtcatacc actacataac     6660

aggactcacc actgataact tgaaagtccc ctgccaacta ccctctcccg agttcttttc     6720

ctgggtggac ggagtgcaga tccataggtt tgcccccaca ccgaagccgt ttttccggga     6780

tgaggtctcg ttctgcgttg ggcttaattc atttgtcgtc gggtcccagc ttccttgcga     6840

ccctgaaccc gacacagacg tattgatgtc catgctaaca gatccatctc atatcacggc     6900

ggagactgca gcgcggcgtt tagcgcgggg gtcaccccca tccgaggcaa gctcctcggc     6960

gagccagcta tcggcaccat cgctgcgagc cacctgcacc acccacggca aagcctatga     7020

tgtggacatg gtggatgcta acctgttcat ggggggcgat gtgactcgga tagagtctgg     7080

gtccaaagtg gtcgttctgg actctctcga cccaatggtc gaagaaagga gcgaccttga     7140

gccttcgata ccatcagaat acatgctccc caagaagagg ttcccaccag ctttaccggc     7200

ctgggcacgg cctgattaca acccaccgct tgtggaatcg tggaaaaggc cagattacca     7260

accggccact gttgcgggct gtgctctccc tcctcctagg aaaaccccga cgcctccccc     7320

aaggaggcgc cggacagtgg gcctaagtga ggactccata ggagatgccc ttcaacagct     7380

ggccattaag tcctttggcc agcccccccc aagcggcgat tcaggccttt ccacgggggc     7440

gggcgctgcc gattccggca gtcagacgcc tcctgatgag ttggcccttt cggagacagg     7500

ttccatctct tccatgcccc ccctcgaggg ggagcttgga gatccagacc tggagcctga     7560

gcaggtagag ccccaacccc ccccccaggg gggggtggca gctcccggct cggactcggg     7620

gtcctggtct acttgctccg aggaggacga ctccgtcgtg tgctgctcca tgtcatactc     7680

ctggaccggg gctctaataa ctccttgtag tcccgaagag gagaagttac cgattaaccc     7740

cttgagcaac tccctgttgc gatatcacaa caaggtgtac tgtaccacaa caaagagcgc     7800

ctcactaagg gctaaaaagg taacttttga taggatgcaa gtgctcgact cctactacga     7860

ctcagtctta aaggacatta agctagcggc ctccaaggtc accgcaaggc tcctcaccat     7920

ggaggaggct tgccagttaa ccccacccca ttctgcaaga tctaaatatg ggtttggggc     7980

taaggaggtc cgcagcttgt ccgggagggc cgttaaccac atcaagtccg tgtggaagga     8040

cctcctggag gactcagaaa caccaattcc cacaaccatt atggccaaaa atgaggtgtt     8100

ctgcgtggac cccaccaagg ggggcaagaa agcagctcgc cttatcgttt accctgacct     8160

cggcgtcagg gtctgcgaga agatggccct ttatgacatt acacaaaaac ttcctcaggc     8220

ggtgatgggg gcttcttatg gattccagta ttcccccgct cagcgggtag agtttctctt     8280

gaaagcatgg gcggaaaaga aggaccctat gggtttttcg tatgataccc gatgctttga     8340

ctcaaccgtc actgagagag acatcaggac tgaggagtcc atatatcggg cctgctcctt     8400

gcccgaggag gcccacactg ccatacactc gctaactgag agactttacg tgggagggcc     8460

tatgttcaac agcaagggcc aaacctgcgg gtacaggcgt tgccgcgcca gcggggtgct     8520

caccactagc atggggaaca ccatcacatg ctacgtgaaa gccttagcgg cttgtaaagc     8580

tgcagggata atcgcgccca caatgctggt atgcggcgat gacttggttg tcatctcaga     8640

aagccagggg accgaggagg acgagcggaa cctgagagcc ttcacggagg ctatgaccag     8700

gtattctgcc cctcctggtg acccccccag accggagtat gatctggagc tgataacatc     8760

ttgctcctca aatgtgtctg tggcgctggg cccacaaggc cgccgcagat actacctgac     8820

cagagaccct accactccaa tcgcccgggc tgcctgggaa acagttagac actcccctgt     8880

caattcatgg ctgggaaaca tcatccagta cgccccgacc atatgggctc gcatggtcct     8940

gatgacacac ttcttctcca ttctcatggc tcaagacacg ctggaccaga acctcaactt     9000

tgagatgtac ggagcggtgt actccgtgag tcccttggac ctcccagcta taattgaaag     9060

gttacatggg cttgacgctt tttctctgca cacatacact ccccacgaac tgacacgggt     9120

ggcttcagcc ctcagaaaac ttggggcgcc acccctcaga gcgtggaaga gccgggcacg     9180

tgcagtcagg gcgtccctca tctcccgtgg ggggagagcg gccgtttgcg gtcgatatct     9240

cttcaattgg gcggtgaaga ccaagctcaa actcactcca ttgccggaag cgcgcctcct     9300

ggatttatcc agctggttca ccgtcggcgc cggcgggggc ggcatttatc acagcgtgtc     9360

gcgtgcccga ccccgcttat tgctctttgg cctactccta ctttttgtag gggtaggcct     9420

tttcctactc cccgctcggt agagcggcac acattagcta cactccatag ctaactgtcc     9480

cttttttttt tttttttttt tttttttttt tttttttttt tttttttttt ttcttttttt     9540

ctcttttcct tctttcttac cttattttac tttctttcct ggtggctcca tcttagccct     9600

agtcacggct agctgtgaaa ggtccgtgag ccgcatgact gcagagagtg ccgtaactgg     9660

tctctctgca gatcatgt                                                   9678


<210>  40
<211>  9659
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  40
gcccgccccc tgatgggggc gacactccgc catgaatcac tcccctgtga ggaactactg       60

tcttcacgca gaaagcgtct agccatggcg ttagtatgag tgtcgtacag cctccaggcc      120

cccccctccc gggagagcca tagtggtctg cggaaccggt gagtacaccg gaattaccgg      180

aaagactggg tcctttcttg gataaaccca ctctatgtcc ggtcatttgg gcacgccccc      240

gcaagactgc tagccgagta gcgttgggtt gcgaaaggcc ttgtggtact gcctgatagg      300

gtgcttgcga gtgccccggg aggtctcgta gaccgtgcat catgagcaca aatcctaaac      360

ctcaaagaaa aaccaaaaga aacacaaacc gccgcccaca ggacgttaag ttcccgggtg      420

gcggtcagat cgttggcgga gtttacttgc tgccgcgcag gggccccagg ttgggtgtgc      480

gcgcgacaag gaagacttct gagcgatccc agccgcgtgg acgacgccag cccatcccga      540

aagatcggcg ctccaccggc aagtcctggg gaaagccagg atatccttgg cccctgtacg      600

gaaacgaggg ttgcggctgg gcgggttggc tcctgtcccc ccgcgggtct cgtcctactt      660

ggggccccac cgacccccgg catagatcac gcaatttggg cagagtcatc gataccatta      720

cgtgtggttt tgccgacctc atggggtaca tccctgtcgt tggcgccccg gttggaggcg      780

tcgccagagc tctggcacac ggtgttaggg tcctggagga cgggataaat tacgcaacag      840

ggaatttacc cggttgctct ttttctatct ttttgcttgc tcttctgtca tgcgtcacag      900

tgccagtgtc tgcagtggaa gtcaggaaca ttagttctag ctactacgcc actaatgatt      960

gctcaaacaa cagcatcacc tggcagctca ctgacgcagt tctccatctt cctggatgcg     1020

tcccatgtga gaatgataat ggcaccttgc attgctggat acaagtaaca cccaacgtgg     1080

ctgtgaaaca ccgcggtgcg ctcactcgta gcctgcgaac acacgtcgac atgatcgtaa     1140

tggcagctac ggcctgctcg gccttgtatg tgggagatgt gtgcggggcc gtgatgattc     1200

tatcgcaggc tttcatggta tcaccacaac gccacaactt cacccaagag tgcaactgtt     1260

ccatctacca aggtcacatc accggccatc gcatggcatg ggacatgatg ctgaactggt     1320

ctccaactct tgccatgatc ctcgcctacg ccgctcgtgt tcccgagatg gtcctcgaaa     1380

ttattttcgg cggccattgg ggtgtggtgt ttggcttggc ctacttctcc atgcaaggag     1440

cgtgggccaa agtcattgcc atcctccttc ttgttgcggg agtggatgca accacctatt     1500

ccagcggcca ggaagcgggt cgtaccgtct tggggttcac taacctcttt acttctggtg     1560

ccaagcagaa cctctattta atcaacacca atggcagctg gcacataaac cggactgccc     1620

tcaattgcaa tgacagctta cagacgggtt tcatggcttc cctgttttac acccacaggt     1680

tcaacagctc tggctgcccc gagcgcttgt cttcctgccg cgggctggac gattttcgca     1740

tcggctgggg aaccttggaa tacgaaaccc acgtcaccaa cgatgaggac atgaggccgt     1800

actgctggca ttaccctccg aggccttgcg gcatcgtccc ggctagaacg gtttgcggac     1860

cggtctattg tttcacccct agccctgttg tcgtgggcac cactgacaag cagggcgtac     1920

ccacctacac ctggggggaa aacgagaccg atgtcttcct gctgaatagc acaagacccc     1980

cgcgaggagc ttggttcggc tgcacttgga tgaacgggac tgggttcact aagacatgcg     2040

gtgcaccacc ttgccgcatt aggaaagact acaacagcac tatcgattta ttgtgcccca     2100

cagactgttt taggaagcac cccgatgcta cctatcttaa gtgtggagca gggccttggt     2160

taactcccag gtgcctggta gactaccctt atagactgtg gcattatccg tgcactgtaa     2220

acttcaccat ctttaaggcg cggatgtatg taggaggggt ggagcatcga ttctccgcag     2280

catgcaactt cacgcgcgga gatcgctgca gactggaaga tagggatagg ggtcagcaga     2340

gtccactgct gcattccact actgagtggg cggtgctccc atgctccttc tctgacctac     2400

cagcactatc cactggccta ttgcacctcc accaaaacat cgtggacgtg cagtaccttt     2460

acggactttc tccggctctg acaagataca tcgtgaagtg ggagtgggtg atcctccttt     2520

tcttgttgtt ggcagacgcc aggatctgtg catgcctttg gatgctcatc atactgggcc     2580

aagccgaagc ggcgcttgag aagctcatca tcttgcactc cgctagtgct gctagtgcca     2640

atggtccgct gtggtttttc atcttcttta cagcggcctg gtacttaaag ggcagggtgg     2700

tccccgtggc cacgtactct gttctcggct tatggtcctt cctcctccta gtcctggcct     2760

taccacagca ggcttatgcc ttggacgctg ctgaacaagg ggaactgggg ctggccatat     2820

tagtaattat atccatcttt actcttaccc cagcatacaa gatcctcctg agccgttcag     2880

tgtggtggct gtcctacatg ctggtcttgg ccgaggccca gattcagcaa tgggttcccc     2940

ccctggaggt ccgagggggg cgtgacggaa tcatctgggt ggctgtcatt ctacacccac     3000

gccttgtgtt tgaggtcacg aaatggttgt tagcaatcct ggggcctgcc tacctcctta     3060

aagcgtctct gctacggata ccgtactttg tgagggccca cgctttgcta cgagtgtgta     3120

ccctggtgaa acacctcgcg ggggctaggt acatccagat gctgttgatc accataggca     3180

gatggaccgg cacttacatc tacgaccacc tctccccttt atcaacttgg gcggcccagg     3240

gtttgcggga cctggcaatc gccgtggagc ctgtggtgtt cagcccaatg gagaagaagg     3300

tcattgtgtg gggggctgag acagtggcgt gtggagacat cctgcatggc ctcccggtct     3360

ccgcgaggct aggtagggag gttctgctcg gccctgccga cggctacacc tccaaggggt     3420

ggaagctcct agctcccatt actgcttaca ctcagcaaac tcgtggtctc ctgggtgcta     3480

tcgtggtcag cctaacgggc cgcgacaaaa atgagcaggc tgggcaggtc caggttctgt     3540

cctccgtcac acaaactttc ttggggacat ccatttcggg cgtcctctgg acagtatatc     3600

acggggctgg taataagacc ttggccggcc ccaagggacc agtcactcag atgtacacca     3660

gcgcagaagg ggacctcgtg ggatggccta gtccccccgg gactaagtca ttggacccct     3720

gtacctgcgg ggccgtagac ctctacctgg tcacccgaaa cgctgatgtc attccggtcc     3780

ggaggaaaga tgaccgacgg ggtgcattac tctcgccaag gcccctctca accctcaaag     3840

gatcatccgg agggcccgtg ctctgctcaa ggggacacgc cgtgggcttg ttcagagcgg     3900

ccgtgtgtgc caggggtgta gccaaatcta ttgacttcat ccccgtcgaa tcactcgatg     3960

tcgccacacg gacgcccagt ttctctgaca acagtacgcc gccagctgtg ccccagtctt     4020

accaggtggg ttacttgcac gcaccaacag gcagcggaaa gagcaccaag gtccctgccg     4080

cgtatgccag tcaggggtat aaagtactcg tactaaatcc ctctgtcgcg gccacacttg     4140

gttttggggc ctacatgtcc aaagcccacg ggatcaaccc taatatcaga actggagtgc     4200

ggaccgttac caccggggac tctatcactt actccactta tggcaagttt atcgcagatg     4260

gaggctgtgc agccggtgcc tatgacatca tcatatgcga cgaatgccat tcagtggacg     4320

ctactaccat ccttggcatt ggaacagtcc ttgaccaagc tgagaccgca ggcgtcaggc     4380

tagtggtttt ggccacagcc acgcctcccg gtacggtgac aactccccac agtaacatag     4440

aggaggtggc ccttggtcac gagggcgaga tcccttttta tggcaaagcc attcccctag     4500

ctttcatcaa ggggggcaga cacttgatct tttgccattc aaagaagaag tgcgacgagc     4560

tcgcagcggc cctccggggc atgggtgtca atgccgttgc atactatagg ggtctcgacg     4620

tctccgttat accaactcaa ggagacgtgg tggttgtcgc cactgatgcc ctaatgactg     4680

ggtacaccgg cgactttgac tctgtcatcg actgtaatgt tgcagtctct cagattgttg     4740

acttcagcct agacccaacc ttcaccatca ccactcaaat cgtccctcag gacgctgtct     4800

cccgtagtca acgtagaggg agaactggga gggggcgatt gggcgtttac aggtatgttt     4860

cgtcaggcga aaggccgtct gggatgttcg acagcgtagt gctctgcgag tgctatgatg     4920

ccggggcagc ctggtacgag cttacacctg ctgagactac ggtgagactc cgggcttatt     4980

tcaacacgcc cggtttgccc gtatgtcaag accacctgga gttctgggaa gcggtcttta     5040

caggtctcac acacattgac gcccacttcc tctcccagac gaagcaagga ggagaaaact     5100

ttgcgtatct aacggcctac caggccacag tatgcgccag ggcaaaggcc cctcctcctt     5160

cgtgggacgt gatgtggaag tgtctaacta ggctcaaacc tacactgact ggtcccaccc     5220

ccctcctgta ccgcttgggt gccgtgacca atgaggtcac cttgacgcac cccgtgacga     5280

aatacatcgc cacgtgcatg caagctgacc tcgagatcat gacaagctca tgggtcctgg     5340

cggggggggt gctagccgcc gtggcagctt actgcctggc gactggctgc atttccatca     5400

ttggccgcct acacctgaat gatcgggtgg ttgtggcccc cgacaaggaa atcttatatg     5460

aggcctttga tgagatggaa gaatgcgcct ccaaagccgc cctcattgag gaagggcagc     5520

ggatggcgga gatgctcaaa tctaagatac aaggcctcct acaacaggcc acaaggcaag     5580

ctcaagacat acagccagct atacagtcat catggcccaa gcttgaacaa ttttgggcca     5640

aacacatgtg gaacttcatc agtggtatac agtacctagc aggactctcc accctaccgg     5700

gaaatcctgc agtagcatca atgatggctt ttagcgccgc gctgactagc ccactaccca     5760

ccagcaccac catcctcttg aacatcatgg gaggatggtt ggcctctcag attgcccccc     5820

ctgccggagc cactggcttc gttgtcagtg gtctagtggg ggcggccgtc ggaagcatag     5880

gcctgggtaa gatactggtg gacgttttgg ccgggtacgg cgcaggcatt tcaggggccc     5940

tcgtagcttt taagatcatg agcggcgaga agcccacggt agaagacgtt gtgaatctcc     6000

tgcctgctat tctgtctcct ggtgcgttgg tagtgggagt catctgtgca gcaatcctgc     6060

gccgccacgt cggtcaggga gagggggcgg tccagtggat gaacagactg atcgccttcg     6120

cctccagggg aaaccacgtt gcccctaccc actacgtggt ggagtctgac gcttcacagc     6180

gtgtaacgca ggtgctgagt tcacttacaa ttaccagctt acttaggaga ctacatgcct     6240

ggatcactga agattgccca gtcccatgct cggggtcttg gctccaggac atttgggatt     6300

gggtttgttc catcctcaca gacttcaaaa actggctgtc ttcaaaatta ctccccaaga     6360

tgcccggcat tccctttatc tcttgccaga agggatacaa gggtgtatgg gctggtacgg     6420

gtgtcatgac tactcggtgc ccatgtggag caaacatctc gggccatgtc cgcatgggca     6480

ccatgaaaat aacaggcccg aagacttgct tgaacctgtg gcaggggact ttccccatta     6540

attgttacac agaagggcct tgcgtgccaa aaccccctcc taattacaag accgcaattt     6600

ggagggtggc agcgtcggag tacgttgagg tcacacagca tggctctttc tcgtatgtaa     6660

cagggttaac cagtgacaac cttaaggtcc cttgccaggt accagctcca gaatttttct     6720

cttgggtgga cggggtgcaa atccaccgat tcgcccccgt tccaggtccc ttctttcggg     6780

atgaggtaac gttcaccgta ggccttaact ccttcgtggt cggctctcag ctcccttgcg     6840

atcctgagcc ggacaccgag gtactggcct ccatgttgac agacccgtcc cacatcaccg     6900

cggaggcggc agccaggcga ttggcaaggg gatctccccc ttcacaggct agctcctcag     6960

cgagccagct ctctgccccg tccttgaagg ctacctgtac cacccataag acagcatatg     7020

attgtgacat ggtggatgcc aaccttttca tgggaggcga tgtgacccgg attgagtctg     7080

actctaaggt gatcgttctc gactccctcg attccatgac tgaggtagag gatgatcgtg     7140

agccttctgt accatcagag tacctgatca agaggagaaa gttcccaccg gcgctgcctc     7200

cttgggcccg tccagactac aatcctgttt tgatcgagac atggaagagg ccgggctatg     7260

aaccacccac tgtcctaggc tgtgccctcc cccccacacc tcaaacgcca gtgcctccac     7320

ctcggaggcg ccgcgccaaa gtcctgaccc aggacaatgt ggaggggatc ctcagggaga     7380

tggctgacaa agtactcagc cctctccaag acaacaatga ctccggtcac tccactggag     7440

cggataccgg aggagacatc gtccagcaac cctctgacga gactgccgct tcagaagcgg     7500

ggtcactgtc ctccatgcct ccccttgagg gagagccggg agaccctgac ctggagtttg     7560

aaccagtggg atccgctccc ccttctgagg gggagtgtga ggtcattgat tcggactcta     7620

agtcgtggtc cacagtctct gatcaagagg attctgttat ctgctgctct atgtcatact     7680

cctggacggg ggccctcata acaccatgtg ggcccgaaga ggagaagtta ccgatcaacc     7740

ctctgagtaa ttcgctcatg cggttccata ataaggtgta ctccacaacc tcgaggagtg     7800

cctctctgag ggcaaagaag gtgacttttg acagggtgca ggtgctggac gcacactatg     7860

actcagtctt gcaggacgtt aagcgggccg cctctaaggt tagtgcgagg ctcctcacgg     7920

tagaggaagc ctgcgcgctg accccgcccc actccgccaa atcgcgatac ggatttgggg     7980

caaaagaggt gcgcagctta tccaggaggg ccgttaacca catccggtcc gtgtgggagg     8040

acctcctgga agaccaacat accccaattg acacaactat catggctaaa aatgaggtgt     8100

tctgcattga tccaactaaa ggtgggaaaa agccagctcg cctcatcgta taccccgacc     8160

ttggggtcag ggtgtgcgaa aagatggccc tctatgacat cgcacaaaag cttcccaaag     8220

cgataatggg gccatcctat gggttccaat actctcccgc agaacgggtc gatttcctcc     8280

tcaaagcttg gggaagtaag aaggacccaa tggggttctc gtatgacacc cgctgctttg     8340

actcaaccgt cacggagagg gacataagaa cagaagaatc catatatcag gcttgttctc     8400

tgcctcaaga agccagaact gtcatacact cgctcactga gagactttac gtaggagggc     8460

ccatgacaaa cagcaaaggg caatcctgcg gctacaggcg ttgccgcgca agcggtgttt     8520

tcaccaccag catggggaat accatgacat gttacatcaa agcccttgca gcgtgtaagg     8580

ctgcagggat cgtggaccct gttatgttgg tgtgtggaga cgacctggtc gtcatctcag     8640

agagccaagg taacgaggag gacgagcgaa acctgagagc tttcacggag gctatgacca     8700

ggtattccgc ccctcccggt gaccttccca gaccggaata tgacttggag cttataacat     8760

cctgctcctc aaacgtatcg gtagcgctgg actctcgggg tcgccgccgg tacttcctaa     8820

ccagagaccc taccactcca atcacccgag ctgcttggga aacagtaaga cactcccctg     8880

tcaattcttg gctgggcaac atcatccagt acgcccccac aatctgggtc cggatggtca     8940

taatgactca cttcttctcc atactattgg cccaggacac tctgaaccaa aatctcaatt     9000

ttgagatgta cggggcagta tactcggtca atccattaga cctaccggcc ataattgaaa     9060

ggctacatgg gcttgaagcc ttttcactgc acacatactc tccccacgaa ctctcacggg     9120

tggcagcaac tctcagaaaa cttggagcgc ctccccttag agcgtggaag agtcgggcgc     9180

gtgccgtgag agcttcactc atcgcccaag gagcgagggc ggccatttgt ggccgctacc     9240

tcttcaactg ggcggtgaaa acaaagctca aactcactcc attgcccgag gcgagccgcc     9300

tggatttatc cgggtggttc accgtgggcg ccggcggggg cgacatttat cacagcgtgt     9360

cgcatgcccg accccgccta ttactccttt gcctactcct acttagcgta ggagtaggca     9420

tctttttact ccccgctcgg tagagcggca aaccctagct acactccata gctagtttcc     9480

gttttttttt ttttgttttt tttttttttt tttttttttt tttttttttt tttcttttcc     9540

tttttttttt ttctctttct tggtggctcc atcttagccc tagtcacggc tagctgtgaa     9600

aggtccgtga gccgcatgac tgcagagagt gccgtaactg gtctctctgc agatcatgt      9659


<210>  41
<211>  9659
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  41
gcccgccccc tgatgggggc gacactccgc catgaatcac tcccctgtga ggaactactg       60

tcttcacgca gaaagcgtct agccatggcg ttagtatgag tgtcgtacag cctccaggcc      120

cccccctccc gggagagcca tagtggtctg cggaaccggt gagtacaccg gaattaccgg      180

aaagactggg tcctttcttg gataaaccca ctctatgtcc ggtcatttgg gcacgccccc      240

gcaagactgc tagccgagta gcgttgggtt gcgaaaggcc ttgtggtact gcctgatagg      300

gtgcttgcga gtgccccggg aggtctcgta gaccgtgcat catgagcaca aatcctaaac      360

ctcaaagaaa aaccaaaaga aacacaaacc gccgcccaca ggacgttaag ttcccgggtg      420

gcggtcagat cgttggcgga gtttacttgc tgccgcgcag gggccccagg ttgggtgtgc      480

gcgcgacaag gaagacttct gagcgatccc agccgcgtgg acgacgccag cccatcccga      540

aagatcggcg ctccaccggc aagtcctggg gaaagccagg atatccttgg cccctgtacg      600

gaaacgaggg ttgcggctgg gcgggttggc tcctgtcccc ccgcgggtct cgtcctactt      660

ggggccccac cgacccccgg catagatcac gcaatttggg cagagtcatc gataccatta      720

cgtgtggttt tgccgacctc atggggtaca tccctgtcgt tggcgccccg gttggaggcg      780

tcgccagagc tctggcacac ggtgttaggg tcctggagga cgggataaat tacgcaacag      840

ggaatttacc cggttgctct ttttctatct ttttgcttgc tcttctgtca tgcgtcacag      900

tgccagtgtc tgcagtggaa gtcaggaaca ttagttctag ctactacgcc actaatgatt      960

gctcaaacaa cagcatcacc tggcagctca ctgacgcagt tctccatctt cctggatgcg     1020

tcccatgtga gaatgataat ggcaccttgc attgctggat acaagtaaca cccaacgtgg     1080

ctgtgaaaca ccgcggtgcg ctcactcgta gcctgcgaac acacgtcgac atgatcgtaa     1140

tggcagctac ggcctgctcg gccttgtatg tgggagatgt gtgcggggcc gtgatgattc     1200

tatcgcaggc tttcatggta tcaccacaac gccacaactt cacccaagag tgcaactgtt     1260

ccatctacca aggtcacatc accggccatc gcatggcatg ggacatgatg ctgaactggt     1320

ctccaactct tgccatgatc ctcgcctacg ccgctcgtgt tcccgagatg gtcctcgaaa     1380

ttattttcgg cggccattgg ggtgtggtgt ttggcttggc ctacttctcc atgcaaggag     1440

cgtgggccaa agtcattgcc atcctccttc ttgttgcggg agtggatgca accacctatt     1500

ccagcggcca ggaagcgggt cgtaccgtct tggggttcac taacctcttt acttctggtg     1560

ccaagcagaa cctctattta atcaacacca atggcagctg gcacataaac cggactgccc     1620

tcaattgcaa tgacagctta cagacgggtt tcatggcttc cctgttttac acccacaggt     1680

tcaacagctc tggctgcccc gagcgcttgt cttcctgccg cgggctggac gattttcgca     1740

tcggctgggg aaccttggaa tacgaaaccc acgtcaccaa cgatgaggac atgaggccgt     1800

actgctggca ttaccctccg aggccttgcg gcatcgtccc ggctagaacg gtttgcggac     1860

cggtctattg tttcacccct agccctgttg tcgtgggcac cactgacaag cagggcgtac     1920

ccacctacac ctggggggaa aacgagaccg atgtcttcct gctgaatagc acaagacccc     1980

cgcgaggagc ttggttcggc tgcacttgga tgaacgggac tgggttcact aagacatgcg     2040

gtgcaccacc ttgccgcatt aggaaagact acaacagcac tatcgattta ttgtgcccca     2100

cagactgttt taggaagcac cccgatgcta cctatcttaa gtgtggagca gggccttggt     2160

taactcccag gtgcctggta gactaccctt atagactgtg gcattatccg tgcactgtaa     2220

acttcaccat ctttaaggcg cggatgtatg taggaggggt ggagcatcga ttctccgcag     2280

catgcaactt cacgcgcgga gatcgctgca gactggaaga tagggatagg ggtcagcaga     2340

gtccactgct gcattccact actgagtggg cggtgctccc atgctccttc tctgacctac     2400

cagcactatc cactggccta ttgcacctcc accaaaacat cgtggacgtg cagtaccttt     2460

acggactttc tccggctctg acaagataca tcgtgaagtg ggagtgggtg atcctccttt     2520

tcttgttgtt ggcagacgcc aggatctgtg catgcctttg gatgctcatc atactgggcc     2580

aagccgaagc ggcgcttgag aagctcatca tcttgcactc cgctagtgct gctagtgcca     2640

atggtccgct gtggtttttc atcttcttta cagcggcctg gtacttaaag ggcagggtgg     2700

tccccgtggc cacgtactct gttctcggct tatggtcctt cctcctccta gtcctggcct     2760

taccacagca ggcttatgcc ttggacgctg ctgaacaagg ggaactgggg ctggccatat     2820

tagtaattat atccatcttt actcttaccc cagcatacaa gatcctcctg agccgttcag     2880

tgtggtggct gtcctacatg ctggtcttgg ccgaggccca gattcagcaa tgggttcccc     2940

ccctggaggt ccgagggggg cgtgacggaa tcatctgggt ggctgtcatt ctacacccac     3000

gccttgtgtt tgaggtcacg aaatggttgt tagcaatcct ggggcctgcc tacctcctta     3060

aagcgtctct gctacggata ccgtactttg tgagggccca cgctttgcta cgagtgtgta     3120

ccctggtgaa acacctcgcg ggggctaggt acatccagat gctgttgatc accataggca     3180

gatggaccgg cacttacatc tacgaccacc tctccccttt atcaacttgg gcggcccagg     3240

gtttgcggga cctggcaatc gccgtggagc ctgtggtgtt cagcccaatg gagaagaagg     3300

tcattgtgtg gggggctgag acagtggcgt gtggagacat cctgcatggc ctcccggtct     3360

ccgcgaggct aggtagggag gttctgctcg gccctgccga cggctacacc tccaaggggt     3420

ggaagctcct agctcccatt actgcttaca ctcagcaaac tcgtggtctc ctgggtgcta     3480

tcgtggtcag cctaacgggc cgcgacaaaa atgagcaggc tgggcaggtc caggttctgt     3540

cctccgtcac acaaactttc ttggggacat ccatttcggg cgtcctctgg acagtatatc     3600

acggggctgg taataagacc ttggccggcc ccaagggacc agtcactcag atgtacacca     3660

gcgcagaagg ggacctcgtg ggatggccta gtccccccgg gactaagtca ttggacccct     3720

gtacctgcgg ggccgtagac ctctacctgg tcacccgaaa cgctgatgtc attccggtcc     3780

ggaggaaaga tgaccgacgg ggtgcattac tctcgccaag gcccctctca accctcaaag     3840

gatcatccgg agggcccgtg ctctgctcaa ggggacacgc cgtgggcttg ttcagagcgg     3900

ccgtgtgtgc caggggtgta gccaaatcta ttgacttcat ccccgtcgaa tcactcgatg     3960

tcgccacacg gacgcccagt ttctctgaca acagtacgcc gccagctgtg ccccagtctt     4020

accaggtggg ttacttgcac gcaccaacag gcagcggaaa gagcaccaag gtccctgccg     4080

cgtatgccag tcaggggtat aaagtactcg tactaaatcc ctctgtcgcg gccacacttg     4140

gttttggggc ctacatgtcc aaagcccacg ggatcaaccc taatatcaga actggagtgc     4200

ggaccgttac caccggggac tctatcactt actccactta tggcaagttt atcgcagatg     4260

gaggctgtgc agccggtgcc tatgacatca tcatatgcga cgaatgccat tcagtggacg     4320

ctactaccat ccttggcatt ggaacagtcc ttgaccaagc tgagaccgca ggcgtcaggc     4380

tagtggtttt ggccacagcc acgcctcccg gtacggtgac aactccccac agtaacatag     4440

aggaggtggc ccttggtcac gagggcgaga tcccttttta tggcaaagcc attcccctag     4500

ctttcatcaa ggggggcaga cacttgatct tttgccattc aaagaagaag tgcgacgagc     4560

tcgcagcggc cctccggggc atgggtgtca atgccgttgc atactatagg ggtctcgacg     4620

tctccgttat accaactcaa ggagacgtgg tggttgtcgc cactgatgcc ctaatgactg     4680

ggtacaccgg cgactttgac tctgtcatcg actgtaatgt tgcagtctct cagattgttg     4740

acctcagcct agacccaacc ttcaccatca ccactcaaat cgtccctcag gacgctgtct     4800

cccgtagtca acgtagaggg agaactggga gggggcgatt gggcgtttac aggtatgttt     4860

cgtcaggcga aaggccgtct gggatgttcg acagcgtagt gctctgcgag tgctatgatg     4920

ccggggcagc ctggtacgag cttacacctg ctgagactac ggtgagactc cgggcttatt     4980

tcaacacgcc cggtttgccc gtatgtcaag accacctgga gttctgggaa gcggtcttta     5040

caggtctcac acacattgac gcccacttcc tctcccagac gaagcaagga ggagaaaact     5100

ttgcgtatct aacggcctac caggccacag tatgcgccag ggcaaaggcc cctcctcctt     5160

cgtgggacgt gatgtggaag tgtctaacta ggctcaaacc tacactgact ggtcccaccc     5220

ccctcctgta ccgcttgggt gccgtgacca atgaggtcac cttgacgcac cccgtgacga     5280

aatacatcgc cacgtgcatg caagctgacc tcgagatcat gacaagctca tgggtcctgg     5340

cggggggggt gctagccgcc gtggcatctt actgcctggc gactggctgc atttccatca     5400

ttggccgcct acacctgaat gatcgggtgg ttgtggcccc cgacaaggaa atcttatatg     5460

aggcctttga tgagatggaa gaatgcgcct ccaaagccgc cctcattgag gaagggcagc     5520

ggatggcgga gatgctcaaa tctaagatac aaggcctcct acaacaggcc acaaggcaag     5580

ctcaagacat acagccagct atacagtcat catggcccaa gcttgaacaa ttttgggcca     5640

aacacatgtg gaacttcatc agtggtatac agtacctagc aggactctcc accctaccgg     5700

gaaatcctgc agtagcatca atgatggctt ttagcgccgc gctgactagc ccactaccca     5760

ccagcaccac catcctcttg aacatcatgg gaggatggtt ggcctctcag attgcccccc     5820

ctgccggagc cactggcttc gttgtcagtg gtctagtggg ggcggccgtc ggaagcatag     5880

gcctgggtaa gatactggtg gacgttttgg ccgggtacgg cgcaggcatt tcaggggccc     5940

tcgtagcttt taagatcatg agcggcgaga agcccacggt agaagacgtt gtgaatctcc     6000

tgcctgctat tctgtctcct ggtgcgttgg tagtgggagt catctgtgca gcaatcctgc     6060

gccgccacgt cggtcaggga gagggggcgg tccagtggat gaacagactg atcgccttcg     6120

cctccagggg aaaccacgtt gcccctaccc actacgtggt ggagtctgac gcttcacagc     6180

gtgtaacgca ggtgctgagt tcacttacaa ttaccagctt acttaggaga ctacatgcct     6240

ggatcactga agattgccca gtcccatgct cggggtcttg gctccaggac atttgggatt     6300

gggtttgttc catcctcaca gacttcaaaa actggctgtc ttcaaaatta ctccccaaga     6360

tgcccggcat tccctttatc tcttgccaga agggatacaa gggtgtatgg gctggtacgg     6420

gtgtcatgac tactcggtgc ccatgtggag caaacatctc gggccatgtc cgcatgggca     6480

ccatgaaaat aacaggcccg aagacttgct tgaacctgtg gcaggggact ttccccatta     6540

attgttacac agaagggcct tgcgtgccaa aaccccctcc taattacaag accgcaattt     6600

ggagggtggc agcgtcggag tacgttgagg tcacacagca tggctctttc tcgtatgtaa     6660

cagggttaac cagtgacaac cttaaggtcc cttgccaggt accagctcca gaatttttct     6720

cttgggtgga cggggtgcaa atccaccgat tcgcccccgt tccaggtccc ttctttcggg     6780

atgaggtaac gttcaccgta ggccttaact ccttcgtggt cggctctcag ctcccttgcg     6840

atcctgagcc ggacaccgag gtactggcct ccatgttgac agacccgtcc cacatcaccg     6900

cggaggcggc agccaggcga ttggcaaggg gatctccccc ttcacaggct agctcctcag     6960

cgagccagct ctctgccccg tccttgaagg ctacctgtac cacccataag acagcatatg     7020

attgtgacat ggtggatgcc aaccttttca tgggaggcga tgtgacccgg attgagtctg     7080

actctaaggt gatcgttctc gactccctcg attccatgac tgaggtagag gatgatcgtg     7140

agccttctgt accatcagag tacctgatca agaggagaaa gttcccaccg gcgctgcctc     7200

cttgggcccg tccagactac aatcctgttt tgatcgagac atggaagagg ccgggctatg     7260

aaccacccac tgtcctaggc tgtgccctcc cccccacacc tcaaacgcca gtgcctccac     7320

ctcggaggcg ccgcgccaaa gtcctgaccc aggacaatgt ggaggggatc ctcagggaga     7380

tggctgacaa agtactcagc cctctccaag acaacaatga ctccggtcac tccactggag     7440

cggataccgg aggagacatc gtccagcaac cctctgacga gactgccgct tcagaagcgg     7500

ggtcactgtc ctccatgcct ccccttgagg gagagccggg agaccctgac ctggagtttg     7560

aaccagtggg atccgctccc ccttctgagg gggagtgtga ggtcattgat tcggactcta     7620

agtcgtggtc cacagtctct gatcaagagg attctgttat ctgctgctct atgtcatact     7680

cctggacggg ggccctcata acaccatgtg ggcccgaaga ggagaagtta ccgatcaacc     7740

ctctgagtaa ttcgctcatg cggttccata ataaggtgta ctccacaacc tcgaggagtg     7800

cctctctgag ggcaaagaag gtgacttttg acagggtgca ggtgctggac gcacactatg     7860

actcagtctt gcaggacgtt aagcgggccg cctctaaggt tagtgcgagg ctcctcacgg     7920

tagaggaagc ctgcgcgctg accccgcccc actccgccaa atcgcgatac ggatttgggg     7980

caaaagaggt gcgcagctta tccaggaggg ccgttaacca catccggtcc gtgtgggagg     8040

acctcctgga agaccaacat accccaattg acacaactat catggctaaa aatgaggtgt     8100

tctgcattga tccaactaaa ggtgggaaaa agccagctcg cctcatcgta taccccgacc     8160

ttggggtcag ggtgtgcgaa aagatggccc tctatgacat cgcacaaaag cttcccaaag     8220

cgataatggg gccatcctat gggttccaat actctcccgc agaacgggtc gatttcctcc     8280

tcaaagcttg gggaagtaag aaggacccaa tggggttctc gtatgacacc cgctgctttg     8340

actcaaccgt cacggagagg gacataagaa cagaagaatc catatatcag gcttgttctc     8400

tgcctcaaga agccagaact gtcatacact cgctcactga gagactttac gtaggagggc     8460

ccatgacaaa cagcaaaggg caatcctgcg gctacaggcg ttgccgcgca agcggtgttt     8520

tcaccaccag catggggaat accatgacat gttacatcaa agcccttgca gcgtgtaagg     8580

ctgcagggat cgtggaccct gttatgttgg tgtgtggaga cgacctggtc gtcatctcag     8640

agagccaagg taacgaggag gacgagcgaa acctgagagc tttcacggag gctatgacca     8700

ggtattccgc ccctcccggt gaccttccca gaccggaata tgacttggag cttataacat     8760

cctgctcctc aaacgtatcg gtagcgctgg actctcgggg tcgccgccgg tacttcctaa     8820

ccagagaccc taccactcca atcacccgag ctgcttggga aacagtaaga cactcccctg     8880

tcaattcttg gctgggcaac atcatccagt acgcccccac aatctgggtc cggatggtca     8940

taatgactca cttcttctcc atactattgg cccaggacac tctgaaccaa aatctcaatt     9000

ttgagatgta cggggcagta tactcggtca atccattaga cctaccggcc ataattgaaa     9060

ggctacatgg gcttgaagcc ttttcactgc acacatactc tccccacgaa ctctcacggg     9120

tggcagcaac tctcagaaaa cttggagcgc ctccccttag agcgtggaag agtcgggcgc     9180

gtgccgtgag agcttcactc atcgcccaag gagcgagggc ggccatttgt ggccgctacc     9240

tcttcaactg ggcggtgaaa acaaagctca aactcactcc attgcccgag gcgagccgcc     9300

tggatttatc cgggtggttc accgtgggcg ccggcggggg cggcatttat cacagcgtgt     9360

cgcatgcccg accccgccta ttactccttt gcctactcct acttagcgta ggagtaggca     9420

tctttttact ccccgctcgg tagagcggca aaccctagct acactccata gctagtttcc     9480

gttttttttt ttttgttttt tttttttttt tttttttttt tttttttttt tttcttttcc     9540

tttttttttt ttctctttct tggtggctcc atcttagccc tagtcacggc tagctgtgaa     9600

aggtccgtga gccgcatgac tgcagagagt gccgtaactg gtctctctgc agatcatgt      9659


<210>  42
<211>  9659
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  42
gcccgccccc tgatgggggc gacactccgc catgaatcac tcccctgtga ggaactactg       60

tcttcacgca gaaagcgtct agccatggcg ttagtatgag tgtcgtacag cctccaggcc      120

cccccctccc gggagagcca tagtggtctg cggaaccggt gagtacaccg gaattaccgg      180

aaagactggg tcctttcttg gataaaccca ctctatgtcc ggtcatttgg gcacgccccc      240

gcaagactgc tagccgagta gcgttgggtt gcgaaaggcc ttgtggtact gcctgatagg      300

gtgcttgcga gtgccccggg aggtctcgta gaccgtgcat catgagcaca aatcctaaac      360

ctcaaagaaa aaccaaaaga aacacaaacc gccgcccaca ggacgttaag ttcccgggtg      420

gcggtcagat cgttggcgga gtttacttgc tgccgcgcag gggccccagg ttgggtgtgc      480

gcgcgacaag gaagacttct gagcgatccc agccgcgtgg acgacgccag cccatcccga      540

aagatcggcg ctccaccggc aagtcctggg gaaagccagg atatccttgg cccctgtacg      600

gaaacgaggg ttgcggctgg gcgggttggc tcctgtcccc ccgcgggtct cgtcctactt      660

ggggccccac cgacccccgg catagatcac gcaatttggg cagagtcatc gataccatta      720

cgtgtggttt tgccgacctc atggggtaca tccctgtcgt tggcgccccg gttggaggcg      780

tcgccagagc tctggcacac ggtgttaggg tcctggagga cgggataaat tacgcaacag      840

ggaatttacc cggttgctct ttttctatct ttttgcttgc tcttctgtca tgcgtcacag      900

tgccagtgtc tgcagtggaa gtcaggaaca ttagttctag ctactacgcc actaatgatt      960

gctcaaacaa cagcatcacc tggcagctca ctgacgcagt tctccatctt cctggatgcg     1020

tcccatgtga gaatgataat ggcaccttgc attgctggat acaagtaaca cccaacgtgg     1080

ctgtgaaaca ccgcggtgcg ctcactcgta gcctgcgaac acacgtcgac atgatcgtaa     1140

tggcagctac ggcctgctcg gccttgtatg tgggagatgt gtgcggggcc gtgatgattc     1200

tatcgcaggc tttcatggta tcaccacaac gccacaactt cacccaagag tgcaactgtt     1260

ccatctacca aggtcacatc accggccatc gcatggcatg ggacatgatg ctgaactggt     1320

ctccaactct tgccatgatc ctcgcctacg ccgctcgtgt tcccgagatg gtcctcgaaa     1380

ttattttcgg cggccattgg ggtgtggtgt ttggcttggc ctacttctcc atgcaaggag     1440

cgtgggccaa agtcattgcc atcctccttc ttgttgcggg agtggatgca accacctatt     1500

ccagcggcca ggaagcgggt cgtaccgtct tggggttcac taacctcttt acttctggtg     1560

ccaagcagaa cctctattta atcaacacca atggcagctg gcacataaac cggactgccc     1620

tcaattgcaa tgacagctta cagacgggtt tcatggcttc cctgttttac acccacaggt     1680

tcaacagctc tggctgcccc gagcgcttgt cttcctgccg cgggctggac gattttcgca     1740

tcggctgggg aaccttggaa tacgaaaccc acgtcaccaa cgatgaggac atgaggccgt     1800

actgctggca ttaccctccg aggccttgcg gcatcgtccc ggctagaacg gtttgcggac     1860

cggtctattg tttcacccct agccctgttg tcgtgggcac cactgacaag cagggcgtac     1920

ccacctacac ctggggggaa aacgagaccg atgtcttcct gctgaatagc acaagacccc     1980

cgcgaggagc ttggttcggc tgcacttgga tgaacgggac tgggttcact aagacatgcg     2040

gtgcaccacc ttgccgcatt aggaaagact acaacagcac tatcgattta ttgtgcccca     2100

cagactgttt taggaagcac cccgatgcta cctatcttaa gtgtggagca gggccttggt     2160

taactcccag gtgcctggta gactaccctt atagactgtg gcattatccg tgcactgtaa     2220

acttcaccat ctttaaggcg cggatgtatg taggaggggt ggagcatcga ttctccgcag     2280

catgcaactt cacgcgcgga gatcgctgca gactggaaga tagggatagg ggtcagcaga     2340

gtccactgct gcattccact actgagtggg cggtgctccc atgctccttc tctgacctac     2400

cagcactatc cactggccta ttgcacctcc accaaaacat cgtggacgtg cagtaccttt     2460

acggactttc tccggctctg acaagataca tcgtgaagtg ggagtgggtg atcctccttt     2520

tcttgttgtt ggcagacgcc aggatctgtg catgcctttg gatgctcatc atactgggcc     2580

aagccgaagc ggcgcttgag aagctcatca tcttgcactc cgctagtgct gctagtgcca     2640

atggtccgct gtggtttttc atcttcttta cagcggcctg gtacttaaag ggcagggtgg     2700

tccccgtggc cacgtactct gttctcggct tatggtcctt cctcctccta gtcctggcct     2760

taccacagca ggcttatgcc ttggacgctg ctgaacaagg ggaactgggg ctggccatat     2820

tagtaattat atccatcttt actcttaccc cagcatacaa gatcctcctg agccgttcag     2880

tgtggtggct gtcctacatg ctggtcttgg ccgaggccca gattcagcaa tgggttcccc     2940

ccctggaggt ccgagggggg cgtgacggaa tcatctgggt ggctgtcatt ctacacccac     3000

gccttgtgtt tgaggtcacg aaatggttgt tagcaatcct ggggcctgcc tacctcctta     3060

aagcgtctct gctacggata ccgtactttg tgagggccca cgctttgcta cgagtgtgta     3120

ccctggtgaa acacctcgcg ggggctaggt acatccagat gctgttgatc accataggca     3180

gatggaccgg cacttacatc tacgaccacc tctccccttt atcaacttgg gcggcccagg     3240

gtttgcggga cctggcaatc gccgtggagc ctgtggtgtt cagcccaatg gagaagaagg     3300

tcattgtgtg gggggctgag acagtggcgt gtggagacat cctgcatggc ctcccggtct     3360

ccgcgaggct aggtagggag gttctgctcg gccctgccga cggctacacc tccaaggggt     3420

ggaagctcct agctcccatt actgcttaca ctcagcaaac tcgtggtctc ctgggtgcta     3480

tcgtggtcag cctaacgggc cgcgacaaaa atgagcaggc tgggcaggtc caggttctgt     3540

cctccgtcac acaaactttc ttggggacat ccatttcggg cgtcctctgg acagtatatc     3600

acggggctgg taataagacc ttggccggcc ccaagggacc agtcactcag atgtacacca     3660

gcgcagaagg ggacctcgtg ggatggccta gtccccccgg gactaagtca ttggacccct     3720

gtacctgcgg ggccgtagac ctctacctgg tcacccgaaa cgctgatgtc attccggtcc     3780

ggaggaaaga tgaccgacgg ggtgcattac tctcgccaag gcccctctca accctcaaag     3840

gatcatccgg agggcccgtg ctctgctcaa ggggacacgc cgtgggcttg ttcagagcgg     3900

ccgtgtgtgc caggggtgta gccaaatcta ttgacttcat ccccgtcgaa tcactcgatg     3960

tcgccacacg gacgcccagt ttctctgaca acagtacgcc gccagctgtg ccccagtctt     4020

accaggtggg ttacttgcac gcaccaacag gcagcggaaa gagcaccaag gtccctgccg     4080

cgtatgccag tcaggggtat aaagtactcg tactaaatcc ctctgtcgcg gccacacttg     4140

gttttggggc ctacatgtcc aaagcccacg ggatcaaccc taatatcaga actggagtgc     4200

ggaccgttac caccggggac tctatcactt actccactta tggcaagttt atcgcagatg     4260

gaggctgtgc agccggtgcc tatgacatca tcatatgcga cgaatgccat tcagtggacg     4320

ctactaccat ccttggcatt ggaacagtcc ttgaccaagc tgagaccgca ggcgtcaggc     4380

tagtggtttt ggccacagcc acgcctcccg gtacggtgac aactccccac agtaacatag     4440

aggaggtggc ccttggtcac gagggcgaga tcccttttta tggcaaagcc attcccctag     4500

ctttcatcaa ggggggcaga cacttgatct tttgccattc aaagaagaag tgcgacgagc     4560

tcgcagcggc cctccggggc atgggtgtca atgccgttgc atactatagg ggtctcgacg     4620

tctccgttat accaactcaa ggagacgtgg tggttgtcgc cactgatgcc ctaatgactg     4680

ggtacaccgg cgactttgac tctgtcatcg actgtaatgt tgcagtctct cagattgttg     4740

acctcagcct agacccaacc ttcaccatca ccactcaaat cgtccctcag gacgctgtct     4800

cccgtagtca acgtagaggg agaactggga gggggcgatt gggcgtttac aggtatgttt     4860

cgtcaggcga aaggccgtct gggatgttcg acagcgtagt gctctgcgag tgctatgatg     4920

ccggggcagc ctggtacgag cttacacctg ctgagactac ggtgagactc cgggcttatt     4980

tcaacacgcc cggtttgccc gtatgtcaag accacctgga gttctgggaa gcggtcttta     5040

caggtctcac acacattgac gcccacttcc tctcccagac gaagcaagga ggagaaaact     5100

ttgcgtatct aacggcctac caggccacag tatgcgccag ggcaaaggcc cctcctcctt     5160

cgtgggacgt gatgtggaag tgtctaacta ggctcaaacc tacactgact ggtcccaccc     5220

ccctcctgta ccgcttgggt gccgtgacca atgaggtcac cttgacgcac cccgtgacga     5280

aatacatcgc cacgtgcatg caagctgacc tcgagatcat gacaagctca tgggtcctgg     5340

cggggggggt gctagccgcc gtggcatctt actgcctggc gactggctgc atttccatca     5400

ttggccgcct acacctgaat gatcgggtgg ttgtggcccc cgacaaggaa atcttatatg     5460

aggcctttga tgagatggaa gaatgcgcct ccaaagccgc cctcattgag gaagggcagc     5520

ggatggcgga gatgctcaaa tctaagatac aaggcctcct acaacaggcc acaaggcaag     5580

ctcaagacat acagccagct atacagtcat catggcccaa gcttgaacaa ttttgggcca     5640

aacacatgtg gaacttcatc agtggtatac agtacctagc aggactctcc accctaccgg     5700

gaaatcctgc agtagcatca atgatggctt ttagcgccgc gctgactagc ccactaccca     5760

ccagcaccac catcctcttg aacatcatgg gaggatggtt ggcctctcag attgcccccc     5820

ctgccggagc cactggcttc gttgtcagtg gtctagtggg ggcggccgtc ggaagcatag     5880

gcctgggtaa gatactggtg gacgttttgg ccgggtacgg cgcaggcatt tcaggggccc     5940

tcgtagcttt taagatcatg agcggcgaga agcccacggt agaagacgtt gtgaatctcc     6000

tgcctgctat tctgtctcct ggtgcgttgg tagtgggagt catctgtgca gcaatcctgc     6060

gccgccacgt cggtcaggga gagggggcgg tccagtggat gaacagactg atcgccttcg     6120

cctccagggg aaaccacgtt gcccctaccc actacgtggt ggagtctgac gcttcacagc     6180

gtgtaacgca ggtgctgagt tcacttacaa ttaccagctt acttaggaga ctacatgcct     6240

ggatcactga agattgccca gtcccatgct cggggtcttg gctccaggac atttgggatt     6300

gggtttgttc catcctcaca gacttcaaaa actggctgtc ttcaaaatta ctccccaaga     6360

tgcccggcat tccctttatc tcttgccaga agggatacaa gggtgtatgg gctggtacgg     6420

gtgtcatgac tactcggtgc ccatgtggag caaacatctc gggccatgtc cgcatgggca     6480

ccatgaaaat aacaggcccg aagacttgct tgaacctgtg gcaggggact ttccccatta     6540

attgttacac agaagggcct tgcgtgccaa aaccccctcc taattacaag accgcaattt     6600

ggagggtggc agcgtcggag tacgttgagg tcacacagca tggctctttc tcgtatgtaa     6660

cagggttaac cagtgacaac cttaaggtcc cttgccaggt accagctcca gaatttttct     6720

cttgggtgga cggggtgcaa atccaccgat tcgcccccgt tccaggtccc ttctttcggg     6780

atgaggtaac gttcaccgta ggccttaact ccttcgtggt cggctctcag ctcccttgcg     6840

atcctgagcc ggacaccgag gtactggcct ccatgttgac agacccgtcc cacatcaccg     6900

cggaggcggc agccaggcga ttggcaaggg gatctccccc ttcacaggct agctcctcag     6960

cgagccagct ctctgccccg tccttgaagg ctacctgtac cacccataag acagcatatg     7020

attgtgacat ggtggatgcc aaccttttca tgggaggcga tgtgacccgg attgagtctg     7080

actctaaggt gatcgttctc gactccctcg attccatgac tgaggtagag gatgatcgtg     7140

agccttctgt accatcagag tacctgatca agaggagaaa gttcccaccg gcgctgcctc     7200

cttgggcccg tccagactac aatcctgttt tgatcgagac atggaagagg ccgggctatg     7260

aaccacccac tgtcctaggc tgtgccctcc cccccacacc tcaaacgcca gtgcctccac     7320

ctcggaggcg ccgcgccaaa gtcctgaccc aggacaatgt ggaggggatc ctcagggaga     7380

tggctgacaa agtactcagc cctctccaag acaacaatga ctccggtcac tccactggag     7440

cggataccgg aggagacatc gtccagcaac cctctgacga gactgccgct tcagaagcgg     7500

ggtcactgtc ctccatgcct ccccttgagg gagagccggg agaccctgac ctggagtttg     7560

aaccagtggg atccgctccc ccttctgagg gggagtgtga ggtcattgat tcggactcta     7620

agtcgtggtc cacagtctct gatcaagagg attctgttat ctgctgctct atgtcatact     7680

cctggacggg ggccctcata acaccatgtg ggcccgaaga ggagaagtta ccgatcaacc     7740

ctctgagtaa ttcgctcatg cggttccata ataaggtgta ctccacaacc tcgaggagtg     7800

cctctctgag ggcaaagaag gtgacttttg acagggtgca ggtgctggac gcacactatg     7860

actcagtctt gcaggacgtt aagcgggccg cctctaaggt tagtgcgagg ctcctcacgg     7920

tagaggaagc ctgcgcgctg accccgcccc actccgccaa atcgcgatac ggatttgggg     7980

caaaagaggt gcgcagctta tccaggaggg ccgttaacca catccggtcc gtgtgggagg     8040

acctcctgga agaccaacat accccaattg acacaactat catggctaaa aatgaggtgt     8100

tctgcattga tccaactaaa ggtgggaaaa agccagctcg cctcatcgta taccccgacc     8160

ttggggtcag ggtgtgcgaa aagatggccc tctatgacat cgcacaaaag cttcccaaag     8220

cgataatggg gccatcctat gggttccaat actctcccgc agaacgggtc gatttcctcc     8280

tcaaagcttg gggaagtaag aaggacccaa tggggttctc gtatgacacc cgctgctttg     8340

actcaaccgt cacggagagg gacataagaa cagaagaatc catatatcag gcttgttctc     8400

tgcctcaaga agccagaact gtcatacact cgctcactga gagactttac gtaggagggc     8460

ccatgacaaa cagcaaaggg caatcctgcg gctacaggcg ttgccgcgca agcggtgttt     8520

tcaccaccag catggggaat accatgacat gttacatcaa agcccttgca gcgtgtaagg     8580

ctgcagggat cgtggaccct gttatgttgg tgtgtggaga cgacctggtc gtcatctcag     8640

agagccaagg taacgaggag gacgagcgaa acctgagagc tttcacggag gctatgacca     8700

ggtattccgc ccctcccggt gaccttccca gaccggaata tgacttggag cttataacat     8760

cctgctcctc aaacgtatcg gtagcgctgg actctcgggg tcgccgccgg tacttcctaa     8820

ccagagaccc taccactcca atcacccgag ctgcttggga aacagtaaga cactcccctg     8880

tcaattcttg gctgggcaac atcatccagt acgcccccac aatctgggtc cggatggtca     8940

taatgactca cttcttctcc atactattgg cccaggacac tctgaaccaa aatctcaatt     9000

ttgagatgta cggggcagta tactcggtca atccattaga cctaccggcc ataattgaaa     9060

ggctacatgg gcttgaagcc ttttcactgc acacatactc tccccacgaa ctctcacggg     9120

tggcagcaac tctcagaaaa cttggagcgc ctccccttag agcgtggaag agtcgggcgc     9180

gtgccgtgag agcttcactc atcgcccaag gagcgagggc ggccatttgt ggccgctacc     9240

tcttcaactg ggcggtgaaa acaaagctca aactcactcc attgcccgag gcgagccgcc     9300

tggatttatc cgggtggttc accgtgggcg ccggcggggg cggcattttt cacagcgtgt     9360

cgcatgcccg accccgccta ttactccttt gcctactcct acttagcgta ggagtaggca     9420

tctttttact ccccgctcgg tagagcggca aaccctagct acactccata gctagtttcc     9480

gttttttttt ttttgttttt tttttttttt tttttttttt tttttttttt tttcttttcc     9540

tttttttttt ttctctttct tggtggctcc atcttagccc tagtcacggc tagctgtgaa     9600

aggtccgtga gccgcatgac tgcagagagt gccgtaactg gtctctctgc agatcatgt      9659


<210>  43
<211>  9659
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  43
gcccgccccc tgatgggggc gacactccgc catgaatcac tcccctgtga ggaactactg       60

tcttcacgca gaaagcgtct agccatggcg ttagtatgag tgtcgtacag cctccaggcc      120

cccccctccc gggagagcca tagtggtctg cggaaccggt gagtacaccg gaattaccgg      180

aaagactggg tcctttcttg gataaaccca ctctatgtcc ggtcatttgg gcacgccccc      240

gcaagactgc tagccgagta gcgttgggtt gcgaaaggcc ttgtggtact gcctgatagg      300

gtgcttgcga gtgccccggg aggtctcgta gaccgtgcat catgagcaca aatcctaaac      360

ctcaaagaaa aaccaaaaga aacacaaacc gccgcccaca ggacgttaag ttcccgggtg      420

gcggtcagat cgttggcgga gtttacttgc tgccgcgcag gggccccagg ttgggtgtgc      480

gcgcgacaag gaagacttct gagcgatccc agccgcgtgg acgacgccag cccatcccga      540

aagatcggcg ctccaccggc aagtcctggg gaaagccagg atatccttgg cccctgtacg      600

gaaacgaggg ttgcggctgg gcgggttggc tcctgtcccc ccgcgggtct cgtcctactt      660

ggggccccac cgacccccgg catagatcac gcaatttggg cagagtcatc gataccatta      720

cgtgtggttt tgccgacctc atggggtaca tccctgtcgt tggcgccccg gttggaggcg      780

tcgccagagc tctggcacac ggtgttaggg tcctggagga cgggataaat tacgcaacag      840

ggaatttacc cggttgctct ttttctatct ttttgcttgc tcttctgtca tgcgtcacag      900

tgccagtgtc tgcagtggaa gtcaggaaca ttagttctag ctactacgcc actaatgatt      960

gctcaaacaa cagcatcacc tggcagctca ctgacgcagt tctccatctt cctggatgcg     1020

tcccatgtga gaatgataat ggcaccttgc attgctggat acaagtaaca cccaacgtgg     1080

ctgtgaaaca ccgcggtgcg ctcactcgta gcctgcgaac acacgtcgac atgatcgtaa     1140

tggcagctac ggcctgctcg gccttgtatg tgggagatgt gtgcggggcc gtgatgattc     1200

tatcgcaggc tttcatggta tcaccacaac gccacaactt cacccaagag tgcaactgtt     1260

ccatctacca aggtcacatc accggccatc gcatggcatg ggacatgatg ctgaactggt     1320

ctccaactct tgccatgatc ctcgcctacg ccgctcgtgt tcccgagatg gtcctcgaaa     1380

ttattttcgg cggccattgg ggtgtggtgt ttggcttggc ctacttctcc atgcaaggag     1440

cgtgggccaa agtcattgcc atcctccttc ttgttgcggg agtggatgca accacctatt     1500

ccagcggcca ggaagcgggt cgtaccgtct tggggttcac taacctcttt acttctggtg     1560

ccaagcagaa cctctattta atcaacacca atggcagctg gcacataaac cggactgccc     1620

tcaattgcaa tgacagctta cagacgggtt tcatggcttc cctgttttac acccacaggt     1680

tcaacagctc tggctgcccc gagcgcttgt cttcctgccg cgggctggac gattttcgca     1740

tcggctgggg aaccttggaa tacgaaaccc acgtcaccaa cgatgaggac atgaggccgt     1800

actgctggca ttaccctccg aggccttgcg gcatcgtccc ggctagaacg gtttgcggac     1860

cggtctattg tttcacccct agccctgttg tcgtgggcac cactgacaag cagggcgtac     1920

ccacctacac ctggggggaa aacgagaccg atgtcttcct gctgaatagc acaagacccc     1980

cgcgaggagc ttggttcggc tgcacttgga tgaacgggac tgggttcact aagacatgcg     2040

gtgcaccacc ttgccgcatt aggaaagact acaacagcac tatcgattta ttgtgcccca     2100

cagactgttt taggaagcac cccgatgcta cctatcttaa gtgtggagca gggccttggt     2160

taactcccag gtgcctggta gactaccctt atagactgtg gcattatccg tgcactgtaa     2220

acttcaccat ctttaaggcg cggatgtatg taggaggggt ggagcatcga ttctccgcag     2280

catgcaactt cacgcgcgga gatcgctgca gactggaaga tagggatagg ggtcagcaga     2340

gtccactgct gcattccact actgagtggg cggtgctccc atgctccttc tctgacctac     2400

cagcactatc cactggccta ttgcacctcc accaaaacat cgtggacgtg cagtaccttt     2460

acggactttc tccggctctg acaagataca tcgtgaagtg ggagtgggtg atcctccttt     2520

tcttgttgtt ggcagacgcc aggatctgtg catgcctttg gatgctcatc atactgggcc     2580

aagccgaagc ggcgcttgag aagctcatca tcttgcactc cgctagtgct gctagtgcca     2640

atggtccgct gtggtttttc atcttcttta cagcggcctg gtacttaaag ggcagggtgg     2700

tccccgtggc cacgtactct gttctcggct tatggtcctt cctcctccta gtcctggcct     2760

taccacagca ggcttatgcc ttggacgctg ctgaacaagg ggaactgggg ctggccatat     2820

tagtaattat atccatcttt actcttaccc cagcatacaa gatcctcctg agccgttcag     2880

tgtggtggct gtcctacatg ctggtcttgg ccgaggccca gattcagcaa tgggttcccc     2940

ccctggaggt ccgagggggg cgtgacggaa tcatctgggt ggctgtcatt ctacacccac     3000

gccttgtgtt tgaggtcacg aaatggttgt tagcaatcct ggggcctgcc tacctcctta     3060

aagcgtctct gctacggata ccgtactttg tgagggccca cgctttgcta cgagtgtgta     3120

ccctggtgaa acacctcgcg ggggctaggt acatccagat gctgttgatc accataggca     3180

gatggaccgg cacttacatc tacgaccacc tctccccttt atcaacttgg gcggcccagg     3240

gtttgcggga cctggcaatc gccgtggagc ctgtggtgtt cagcccaatg gagaagaagg     3300

tcattgtgtg gggggctgag acagtggcgt gtggagacat cctgcatggc ctcccggtct     3360

ccgcgaggct aggtagggag gttctgctcg gccctgccga cggctacacc tccaaggggt     3420

ggaagctcct agctcccatt actgcttaca ctcagcaaac tcgtggtctc ctgggtgcta     3480

tcgtggtcag cctaacgggc cgcgacaaaa atgagcaggc tgggcaggtc caggttctgt     3540

cctccgtcac acaaactttc ttggggacat ccatttcggg cgtcctctgg acagtatatc     3600

acggggctgg taataagacc ttggccggcc ccaagggacc agtcactcag atgtacacca     3660

gcgcagaagg ggacctcgtg ggatggccta gtccccccgg gactaagtca ttggacccct     3720

gtacctgcgg ggccgtagac ctctacctgg tcacccgaaa cgctgatgtc attccggtcc     3780

ggaggaaaga tgaccgacgg ggtgcattac tctcgccaag gcccctctca accctcaaag     3840

gatcatccgg agggcccgtg ctctgctcaa ggggacacgc cgtgggcttg ttcagagcgg     3900

ccgtgtgtgc caggggtgta gccaaatcta ttgacttcat ccccgtcgaa tcactcgatg     3960

tcgccacacg gacgcccagt ttctctgaca acagtacgcc gccagctgtg ccccagtctt     4020

accaggtggg ttacttgcac gcaccaacag gcagcggaaa gagcaccaag gtccctgccg     4080

cgtatgccag tcaggggtat aaagtactcg tactaaatcc ctctgtcgcg gccacacttg     4140

gttttggggc ctacatgtcc aaagcccacg ggatcaaccc taatatcaga actggagtgc     4200

ggaccgttac caccggggac tctatcactt actccactta tggcaagttt atcgcagatg     4260

gaggctgtgc agccggtgcc tatgacatca tcatatgcga cgaatgccat tcagtggacg     4320

ctactaccat ccttggcatt ggaacagtcc ttgaccaagc tgagaccgca ggcgtcaggc     4380

tagtggtttt ggccacagcc acgcctcccg gtacggtgac aactccccac agtaacatag     4440

aggaggtggc ccttggtcac gagggcgaga tcccttttta tggcaaagcc attcccctag     4500

ctttcatcaa ggggggcaga cacttgatct tttgccattc aaagaagaag tgcgacgagc     4560

tcgcagcggc cctccggggc atgggtgtca atgccgttgc atactatagg ggtctcgacg     4620

tctccgttat accaactcaa ggagacgtgg tggttgtcgc cactgatgcc ctaatgactg     4680

ggtacaccgg cgactttgac tctgtcatcg actgtaatgt tgcagtctct cagattgttg     4740

acctcagcct agacccaacc ttcaccatca ccactcaaat cgtccctcag gacgctgtct     4800

cccgtagtca acgtagaggg agaactggga gggggcgatt gggcgtttac aggtatgttt     4860

cgtcaggcga aaggccgtct gggatgttcg acagcgtagt gctctgcgag tgctatgatg     4920

ccggggcagc ctggtacgag cttacacctg ctgagactac ggtgagactc cgggcttatt     4980

tcaacacgcc cggtttgccc gtatgtcaag accacctgga gttctgggaa gcggtcttta     5040

caggtctcac acacattgac gcccacttcc tctcccagac gaagcaagga ggagaaaact     5100

ttgcgtatct aacggcctac caggccacag tatgcgccag ggcaaaggcc cctcctcctt     5160

cgtgggacgt gatgtggaag tgtctaacta ggctcaaacc tacactgact ggtcccaccc     5220

ccctcctgta ccgcttgggt gccgtgacca atgaggtcac cttgacgcac cccgtgacga     5280

aatacatcgc cacgtgcatg caagctgacc tcgagatcat gacaagctca tgggtcctgg     5340

cggggggggt gctagccgcc gtggcatctt actgcctggc gactggctgc atttccatca     5400

ttggccgcct acacctgaat gatcgggtgg ttgtggcccc cgacaaggaa atcttatatg     5460

aggcctttga tgagatggaa gaatgcgcct ccaaagccgc cctcattgag gaagggcagc     5520

ggatggcgga gatgctcaaa tctaagatac aaggcctcct acaacaggcc acaaggcaag     5580

ctcaagacat acagccagct atacagtcat catggcccaa gcttgaacaa ttttgggcca     5640

aacacatgtg gaacttcatc agtggtatac agtacctagc aggactctcc accctaccgg     5700

gaaatcctgc agtagcatca atgatggctt ttagcgccgc gctgactagc ccactaccca     5760

ccagcaccac catcctcttg aacatcatgg gaggatggtt ggcctctcag attgcccccc     5820

ctgccggagc cactggcttc gttgtcagtg gtctagtggg ggcggccgtc ggaagcatag     5880

gcctgggtaa gatactggtg gacgttttgg ccgggtacgg cgcaggcatt tcaggggccc     5940

tcgtagcttt taagatcatg agcggcgaga agcccacggt agaagacgtt gtgaatctcc     6000

tgcctgctat tctgtctcct ggtgcgttgg tagtgggagt catctgtgca gcaatcctgc     6060

gccgccacgt cggtcaggga gagggggcgg tccagtggat gaacagactg atcgccttcg     6120

cctccagggg aaaccacgtt gcccctaccc actacgtggt ggagtctgac gcttcacagc     6180

gtgtaacgca ggtgctgagt tcacttacaa ttaccagctt acttaggaga ctacatgcct     6240

ggatcactga agattgccca gtcccatgct cggggtcttg gctccaggac atttgggatt     6300

gggtttgttc catcctcaca gacttcaaaa actggctgtc ttcaaaatta ctccccaaga     6360

tgcccggcat tccctttatc tcttgccaga agggatacaa gggtgtatgg gctggtacgg     6420

gtgtcatgac tactcggtgc ccatgtggag caaacatctc gggccatgtc cgcatgggca     6480

ccatgaaaat aacaggcccg aagacttgct tgaacctgtg gcaggggact ttccccatta     6540

attgttacac agaagggcct tgcgtgccaa aaccccctcc taattacaag accgcaattt     6600

ggagggtggc agcgtcggag tacgttgagg tcacacagca tggctctttc tcgtatgtaa     6660

cagggttaac cagtgacaac cttaaggtcc cttgccaggt accagctcca gaatttttct     6720

cttgggtgga cggggtgcaa atccaccgat tcgcccccgt tccaggtccc ttctttcggg     6780

atgaggtaac gttcaccgta ggccttaact ccttcgtggt cggctctcag ctcccttgcg     6840

atcctgagcc ggacaccgag gtactggcct ccatgttgac agacccgtcc cacatcaccg     6900

cggaggcggc agccaggcga ttggcaaggg gatctccccc ttcacaggct agctcctcag     6960

cgagccagct ctctgccccg tccttgaagg ctacctgtac cacccataag acagcatatg     7020

attgtgacat ggtggatgcc aaccttttca tgggaggcga tgtgacccgg attgagtctg     7080

actctaaggt gatcgttctc gactccctcg attccatgac tgaggtagag gatgatcgtg     7140

agccttctgt accatcagag tacctgatca agaggagaaa gttcccaccg gcgctgcctc     7200

cttgggcccg tccagactac aatcctgttt tgatcgagac atggaagagg ccgggctatg     7260

aaccacccac tgtcctaggc tgtgccctcc cccccacacc tcaaacgcca gtgcctccac     7320

ctcggaggcg ccgcgccaaa gtcctgaccc aggacaatgt ggaggggatc ctcagggaga     7380

tggctgacaa agtactcagc cctctccaag acaacaatga ctccggtcac tccactggag     7440

cggataccgg aggagacatc gtccagcaac cctctgacga gactgccgct tcagaagcgg     7500

ggtcactgtc ctccatgcct ccccttgagg gagagccggg agaccctgac ctggagtttg     7560

aaccagtggg atccgctccc ccttctgagg gggagtgtga ggtcattgat tcggactcta     7620

agtcgtggtc cacagtctct gatcaagagg attctgttat ctgctgctct atgtcatact     7680

cctggacggg ggccctcata acaccatgtg ggcccgaaga ggagaagtta ccgatcaacc     7740

ctctgagtaa ttcgctcatg cggttccata ataaggtgta ctccacaacc tcgaggagtg     7800

cctctctgag ggcaaagaag gtgacttttg acagggtgca ggtgctggac gcacactatg     7860

actcagtctt gcaggacgtt aagcgggccg cctctaaggt tagtgcgagg ctcctcacgg     7920

tagaggaagc ctgcgcgctg accccgcccc actccgccaa atcgcgatac ggatttgggg     7980

caaaagaggt gcgcagctta tccaggaggg ccgttaacca catccggtcc gtgtgggagg     8040

acctcctgga agaccaacat accccaattg acacaactat catggctaaa aatgaggtgt     8100

tctgcattga tccaactaaa ggtgggaaaa agccagctcg cctcatcgta taccccgacc     8160

ttggggtcag ggtgtgcgaa aagatggccc tctatgacat cgcacaaaag cttcccaaag     8220

cgataatggg gccatcctat gggttccaat actctcccgc agaacgggtc gatttcctcc     8280

tcaaagcttg gggaagtaag aaggacccaa tggggttctc gtatgacacc cgctgctttg     8340

actcaaccgt cacggagagg gacataagaa cagaagaatc catatatcag gcttgttctc     8400

tgcctcaaga agccagaact gtcatacact cgctcactga gagactttac gtaggagggc     8460

ccatgacaaa cagcaaaggg caatcctgcg gctacaggcg ttgccgcgca agcggtgttt     8520

tcaccaccag catggggaat accatgacat gttacatcaa agcccttgca gcgtgtaagg     8580

ctgcagggat cgtggaccct gttatgttgg tgtgtggaga cgacctggtc gtcatctcag     8640

agagccaagg taacgaggag gacgagcgaa acctgagagc tttcacggag gctatgacca     8700

ggtattccgc ccctcccggt gaccttccca gaccggaata tgacttggag cttataacat     8760

cctgctcctc aaacgtatcg gtagcgctgg actctcgggg tcgccgccgg tacttcctaa     8820

ccagagaccc taccactcca atcacccgag ctgcttggga aacagtaaga cactcccctg     8880

tcaattcttg gctgggcaac atcatccagt acgcccccac aatctgggtc cggatggtca     8940

taatgactca cttcttctcc atactattgg cccaggacac tctgaaccaa aatctcaatt     9000

ttgagatgta cggggcagta tactcggtca atccattaga cctaccggcc ataattgaaa     9060

ggctacatgg gcttgaagcc ttttcactgc acacatactc tccccgcgaa ctctcacggg     9120

tggcagcaac tctcagaaaa cttggagcgc ctccccttag agcgtggaag agtcgggcgc     9180

gtgccgtgag agcttcactc atcgcccaag gagcgagggc ggccatttgt ggccgctacc     9240

tcttcaactg ggcggtgaaa acaaagctca aactcactcc attgcccgag gcgagccgcc     9300

tggatttatc cgggtggttc accgtgggcg ccggcggggg cggcatttat cacagcgtgt     9360

cgcatgcccg accccgccta ttactccttt gcctactcct acttagcgta ggagtaggca     9420

tctttttact ccccgctcgg tagagcggca aaccctagct acactccata gctagtttcc     9480

gttttttttt ttttgttttt tttttttttt tttttttttt tttttttttt tttcttttcc     9540

tttttttttt ttctctttct tggtggctcc atcttagccc tagtcacggc tagctgtgaa     9600

aggtccgtga gccgcatgac tgcagagagt gccgtaactg gtctctctgc agatcatgt      9659


<210>  44
<211>  9659
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  44
gcccgccccc tgatgggggc gacactccgc catgaatcac tcccctgtga ggaactactg       60

tcttcacgca gaaagcgtct agccatggcg ttagtatgag tgtcgtacag cctccaggcc      120

cccccctccc gggagagcca tagtggtctg cggaaccggt gagtacaccg gaattaccgg      180

aaagactggg tcctttcttg gataaaccca ctctatgtcc ggtcatttgg gcacgccccc      240

gcaagactgc tagccgagta gcgttgggtt gcgaaaggcc ttgtggtact gcctgatagg      300

gtgcttgcga gtgccccggg aggtctcgta gaccgtgcat catgagcaca aatcctaaac      360

ctcaaagaaa aaccaaaaga aacacaaacc gccgcccaca ggacgttaag ttcccgggtg      420

gcggtcagat cgttggcgga gtttacttgc tgccgcgcag gggccccagg ttgggtgtgc      480

gcgcgacaag gaagacttct gagcgatccc agccgcgtgg acgacgccag cccatcccga      540

aagatcggcg ctccaccggc aagtcctggg gaaagccagg atatccttgg cccctgtacg      600

gaaacgaggg ttgcggctgg gcgggttggc tcctgtcccc ccgcgggtct cgtcctactt      660

ggggccccac cgacccccgg catagatcac gcaatttggg cagagtcatc gataccatta      720

cgtgtggttt tgccgacctc atggggtaca tccctgtcgt tggcgccccg gttggaggcg      780

tcgccagagc tctggcacac ggtgttaggg tcctggagga cgggataaat tacgcaacag      840

ggaatttacc cggttgctct ttttctatct ttttgcttgc tcttctgtca tgcgtcacag      900

tgccagtgtc tgcagtggaa gtcaggaaca ttagttctag ctactacgcc actaatgatt      960

gctcaaacaa cagcatcacc tggcagctca ctgacgcagt tctccatctt cctggatgcg     1020

tcccatgtga gaatgataat ggcaccttgc attgctggat acaagtaaca cccaacgtgg     1080

ctgtgaaaca ccgcggtgcg ctcactcgta gcctgcgaac acacgtcgac atgatcgtaa     1140

tggcagctac ggcctgctcg gccttgtatg tgggagatgt gtgcggggcc gtgatgattc     1200

tatcgcaggc tttcatggta tcaccacaac gccacaactt cacccaagag tgcaactgtt     1260

ccatctacca aggtcacatc accggccatc gcatggcatg ggacatgatg ctgaactggt     1320

ctccaactct tgccatgatc ctcgcctacg ccgctcgtgt tcccgagatg gtcctcgaaa     1380

ttattttcgg cggccattgg ggtgtggtgt ttggcttggc ctacttctcc atgcaaggag     1440

cgtgggccaa agtcattgcc atcctccttc ttgttgcggg agtggatgca accacctatt     1500

ccagcggcca ggaagcgggt cgtaccgtct tggggttcac taacctcttt acttctggtg     1560

ccaagcagaa cctctattta atcaacacca atggcagctg gcacataaac cggactgccc     1620

tcaattgcaa tgacagctta cagacgggtt tcatggcttc cctgttttac acccacaggt     1680

tcaacagctc tggctgcccc gagcgcttgt cttcctgccg cgggctggac gattttcgca     1740

tcggctgggg aaccttggaa tacgaaaccc acgtcaccaa cgatgaggac atgaggccgt     1800

actgctggca ttaccctccg aggccttgcg gcatcgtccc ggctagaacg gtttgcggac     1860

cggtctattg tttcacccct agccctgttg tcgtgggcac cactgacaag cagggcgtac     1920

ccacctacac ctggggggaa aacgagaccg atgtcttcct gctgaatagc acaagacccc     1980

cgcgaggagc ttggttcggc tgcacttgga tgaacgggac tgggttcact aagacatgcg     2040

gtgcaccacc ttgccgcatt aggaaagact acaacagcac tatcgattta ttgtgcccca     2100

cagactgttt taggaagcac cccgatgcta cctatcttaa gtgtggagca gggccttggt     2160

taactcccag gtgcctggta gactaccctt atagactgtg gcattatccg tgcactgtaa     2220

acttcaccat ctttaaggcg cggatgtatg taggaggggt ggagcatcga ttctccgcag     2280

catgcaactt cacgcgcgga gatcgctgca gactggaaga tagggatagg ggtcagcaga     2340

gtccactgct gcattccact actgagtggg cggtgctccc atgctccttc tctgacctac     2400

cagcactatc cactggccta ttgcacctcc accaaaacat cgtggacgtg cagtaccttt     2460

acggactttc tccggctctg acaagataca tcgtgaagtg ggagtgggtg atcctccttt     2520

tcttgttgtt ggcagacgcc aggatctgtg catgcctttg gatgctcatc atactgggcc     2580

aagccgaagc ggcgcttgag aagctcatca tcttgcactc cgctagtgct gctagtgcca     2640

atggtccgct gtggtgtttc atcttcttta cagcggcctg gtacttaaag ggcagggtgg     2700

tccccgtggc cacgtactct gttctcggct tatggtcctt cctcctccta gtcctggcct     2760

taccacagca ggcttatgcc ttggacgctg ctgaacaagg ggaactgggg ctggccatat     2820

tagtaattat atccatcttt actcttaccc cagcatacaa gatcctcctg agccgttcag     2880

tgtggtggct gtcctacatg ctggtcttgg ccgaggccca gattcagcaa tgggttcccc     2940

ccctggaggt ccgagggggg cgtgacggaa tcatctgggt ggctgtcatt ctacacccac     3000

gccttgtgtt tgaggtcacg aaatggttgt tagcaatcct ggggcctgcc tacctcctta     3060

aagcgtctct gctacggata ccgtactttg tgagggccca cgctttgcta cgagtgtgta     3120

ccctggtgaa acacctcgcg ggggctaggt acatccagat gctgttgatc accataggca     3180

gatggaccgg cacttacatc tacgaccacc tctccccttt atcaacttgg gcggcccagg     3240

gtttgcggga cctggcaatc gccgtggagc ctgtggtgtt cagcccaatg gagaagaagg     3300

tcattgtgtg gggggctgag acagtggcgt gtggagacat cctgcatggc ctcccggtct     3360

ccgcgaggct aggtagggag gttctgctcg gccctgccga cggctacacc tccaaggggt     3420

ggaagctcct agctcccatt actgcttaca ctcagcaaac tcgtggtctc ctgggtgcta     3480

tcgtggtcag cctaacgggc cgcgacaaaa atgagcaggc tgggcaggtc caggttctgt     3540

cctccgtcac acaaactttc ttggggacat ccatttcggg cgtcctctgg acagtatatc     3600

acggggctgg taataagacc ttggccggcc ccaagggacc agtcactcag atgtacacca     3660

gcgcagaagg ggacctcgtg ggatggccta gtccccccgg gactaagtca ttggacccct     3720

gtacctgcgg ggccgtagac ctctacctgg tcacccgaaa cgctgatgtc attccggtcc     3780

ggaggaaaga tgaccgacgg ggtgcattac tctcgccaag gcccctctca accctcaaag     3840

gatcatccgg agggcccgtg ctctgctcaa ggggacacgc cgtgggcttg ttcagagcgg     3900

ccgtgtgtgc caggggtgta gccaaatcta ttgacttcat ccccgtcgaa tcactcgatg     3960

tcgccacacg gacgcccagt ttctctgaca acagtacgcc gccagctgtg ccccagtctt     4020

accaggtggg ttacttgcac gcaccaacag gcagcggaaa gagcaccaag gtccctgccg     4080

cgtatgccag tcaggggtat aaagtactcg tactaaatcc ctctgtcgcg gccacacttg     4140

gttttggggc ctacatgtcc aaagcccacg ggatcaaccc taatatcaga actggagtgc     4200

ggaccgttac caccggggac tctatcactt actccactta tggcaagttt atcgcagatg     4260

gaggctgtgc agccggtgcc tatgacatca tcatatgcga cgaatgccat tcagtggacg     4320

ctactaccat ccttggcatt ggaacagtcc ttgaccaagc tgagaccgca ggcgtcaggc     4380

tagtggtttt ggccacagcc acgcctcccg gtacggtgac aactccccac agtaacatag     4440

aggaggtggc ccttggtcac gagggcgaga tcccttttta tggcaaagcc attcccctag     4500

ctttcatcaa ggggggcaga cacttgatct tttgccattc aaagaagaag tgcgacgagc     4560

tcgcagcggc cctccggggc atgggtgtca atgccgttgc atactatagg ggtctcgacg     4620

tctccgttat accaactcaa ggagacgtgg tggttgtcgc cactgatgcc ctaatgactg     4680

ggtacaccgg cgactttgac tctgtcatcg actgtaatgt tgcagtctct cagattgttg     4740

acctcagcct agacccaacc ttcaccatca ccactcaaat cgtccctcag gacgctgtct     4800

cccgtagtca acgtagaggg agaactggga gggggcgatt gggcgtttac aggtatgttt     4860

cgtcaggcga aaggccgtct gggatgttcg acagcgtagt gctctgcgag tgctatgatg     4920

ccggggcagc ctggtacgag cttacacctg ctgagactac ggtgagactc cgggcttatt     4980

tcaacacgcc cggtttgccc gtatgtcaag accacctgga gttctgggaa gcggtcttta     5040

caggtctcac acacattgac gcccacttcc tctcccagac gaagcaagga ggagaaaact     5100

ttgcgtatct aacggcctac caggccacag tatgcgccag ggcaaaggcc cctcctcctt     5160

cgtgggacgt gatgtggaag tgtctaacta ggctcaaacc tacactgact ggtcccaccc     5220

ccctcctgta ccgcttgggt gccgtgacca atgaggtcac cttgacgcac cccgtgacga     5280

aatacatcgc cacgtgcatg caagctgacc tcgagatcat gacaagctca tgggtcctgg     5340

cggggggggt gctagccgcc gtggcatctt actgcctggc gactggctgc atttccatca     5400

ttggccgcct acacctgaat gatcgggtgg ttgtggcccc cgacaaggaa atcttatatg     5460

aggcctttga tgagatggaa gaatgcgcct ccaaagccgc cctcattgag gaagggcagc     5520

ggatggcgga gatgctcaaa tctaagatac aaggcctcct acaacaggcc acaaggcaag     5580

ctcaagacat acagccagct atacagtcat catggcccaa gcttgaacaa ttttgggcca     5640

aacacatgtg gaacttcatc agtggtatac agtacctagc aggactctcc accctaccgg     5700

gaaatcctgc agtagcatca atgatggctt ttagcgccgc gctgactagc ccactaccca     5760

ccagcaccac catcctcttg aacatcatgg gaggatggtt ggcctctcag attgcccccc     5820

ctgccggagc cactggcttc gttgtcagtg gtctagtggg ggcggccgtc ggaagcatag     5880

gcctgggtaa gatactggtg gacgttttgg ccgggtacgg cgcaggcatt tcaggggccc     5940

tcgtagcttt taagatcatg agcggcgaga agcccacggt agaagacgtt gtgaatctcc     6000

tgcctgctat tctgtctcct ggtgcgttgg tagtgggagt catctgtgca gcaatcctgc     6060

gccgccacgt cggtcaggga gagggggcgg tccagtggat gaacagactg atcgccttcg     6120

cctccagggg aaaccacgtt gcccctaccc actacgtggt ggagtctgac gcttcacagc     6180

gtgtaacgca ggtgctgagt tcacttacaa ttaccagctt acttaggaga ctacatgcct     6240

ggatcactga agattgccca gtcccatgct cggggtcttg gctccaggac atttgggatt     6300

gggtttgttc catcctcaca gacttcaaaa actggctgtc ttcaaaatta ctccccaaga     6360

tgcccggcat tccctttatc tcttgccaga agggatacaa gggtgtatgg gctggtacgg     6420

gtgtcatgac tactcggtgc ccatgtggag caaacatctc gggccatgtc cgcatgggca     6480

ccatgaaaat aacaggcccg aagacttgct tgaacctgtg gcaggggact ttccccatta     6540

attgttacac agaagggcct tgcgtgccaa aaccccctcc taattacaag accgcaattt     6600

ggagggtggc agcgtcggag tacgttgagg tcacacagca tggctctttc tcgtatgtaa     6660

cagggttaac cagtgacaac cttaaggtcc cttgccaggt accagctcca gaatttttct     6720

cttgggtgga cggggtgcaa atccaccgat tcgcccccgt tccaggtccc ttctttcggg     6780

atgaggtaac gttcaccgta ggccttaact ccttcgtggt cggctctcag ctcccttgcg     6840

atcctgagcc ggacaccgag gtactggcct ccatgttgac agacccgtcc cacatcaccg     6900

cggaggcggc agccaggcga ttggcaaggg gatctccccc ttcacaggct agctcctcag     6960

cgagccagct ctctgccccg tccttgaagg ctacctgtac cacccataag acagcatatg     7020

attgtgacat ggtggatgcc aaccttttca tgggaggcga tgtgacccgg attgagtctg     7080

actctaaggt gatcgttctc gactccctcg attccatgac tgaggtagag gatgatcgtg     7140

agccttctgt accatcagag tacctgatca agaggagaaa gttcccaccg gcgctgcctc     7200

cttgggcccg tccagactac aatcctgttt tgatcgagac atggaagagg ccgggctatg     7260

aaccacccac tgtcctaggc tgtgccctcc cccccacacc tcaaacgcca gtgcctccac     7320

ctcggaggcg ccgcgccaaa gtcctgaccc aggacaatgt ggaggggatc ctcagggaga     7380

tggctgacaa agtactcagc cctctccaag acaacaatga ctccggtcac tccactggag     7440

cggataccgg aggagacatc gtccagcaac cctctgacga gactgccgct tcagaagcgg     7500

ggtcactgtc ctccatgcct ccccttgagg gagagccggg agaccctgac ctggagtttg     7560

aaccagtggg atccgctccc ccttctgagg gggagtgtga ggtcattgat tcggactcta     7620

agtcgtggtc cacagtctct gatcaagagg attctgttat ctgctgctct atgtcatact     7680

cctggacggg ggccctcata acaccatgtg ggcccgaaga ggagaagtta ccgatcaacc     7740

ctctgagtaa ttcgctcatg cggttccata ataaggtgta ctccacaacc tcgaggagtg     7800

cctctctgag ggcaaagaag gtgacttttg acagggtgca ggtgctggac gcacactatg     7860

actcagtctt gcaggacgtt aagcgggccg cctctaaggt tagtgcgagg ctcctcacgg     7920

tagaggaagc ctgcgcgctg accccgcccc actccgccaa atcgcgatac ggatttgggg     7980

caaaagaggt gcgcagctta tccaggaggg ccgttaacca catccggtcc gtgtgggagg     8040

acctcctgga agaccaacat accccaattg acacaactat catggctaaa aatgaggtgt     8100

tctgcattga tccaactaaa ggtgggaaaa agccagctcg cctcatcgta taccccgacc     8160

ttggggtcag ggtgtgcgaa aagatggccc tctatgacat cgcacaaaag cttcccaaag     8220

cgataatggg gccatcctat gggttccaat actctcccgc agaacgggtc gatttcctcc     8280

tcaaagcttg gggaagtaag aaggacccaa tggggttctc gtatgacacc cgctgctttg     8340

actcaaccgt cacggagagg gacataagaa cagaagaatc catatatcag gcttgttctc     8400

tgcctcaaga agccagaact gtcatacact cgctcactga gagactttac gtaggagggc     8460

ccatgacaaa cagcaaaggg caatcctgcg gctacaggcg ttgccgcgca agcggtgttt     8520

tcaccaccag catggggaat accatgacat gttacatcaa agcccttgca gcgtgtaagg     8580

ctgcagggat cgtggaccct gttatgttgg tgtgtggaga cgacctggtc gtcatctcag     8640

agagccaagg taacgaggag gacgagcgaa acctgagagc tttcacggag gctatgacca     8700

ggtattccgc ccctcccggt gaccttccca gaccggaata tgacttggag cttataacat     8760

cctgctcctc aaacgtatcg gtagcgctgg actctcgggg tcgccgccgg tacttcctaa     8820

ccagagaccc taccactcca atcacccgag ctgcttggga aacagtaaga cactcccctg     8880

tcaattcttg gctgggcaac atcatccagt acgcccccac aatctgggtc cggatggtca     8940

taatgactca cttcttctcc atactattgg cccaggacac tctgaaccaa aatctcaatt     9000

ttgagatgta cggggcagta tactcggtca atccattaga cctaccggcc ataattgaaa     9060

ggctacatgg gcttgaagcc ttttcactgc acacatactc tccccgcgaa ctctcacggg     9120

tggcagcaac tctcagaaaa cttggagcgc ctccccttag agcgtggaag agtcgggcgc     9180

gtgccgtgag agcttcactc atcgcccaag gagcgagggc ggccatttgt ggccgctacc     9240

tcttcaactg ggcggtgaaa acaaagctca aactcactcc attgcccgag gcgagccgcc     9300

tggatttatc cgggtggttc accgtgggcg ccggcggggg cggcatttat cacagcgtgt     9360

cgcatgcccg accccgccta ttactccttt gcctactcct acttagcgta ggagtaggca     9420

tctttttact ccccgctcgg tagagcggca aaccctagct acactccata gctagtttcc     9480

gttttttttt ttttgttttt tttttttttt tttttttttt tttttttttt tttcttttcc     9540

tttttttttt ttctctttct tggtggctcc atcttagccc tagtcacggc tagctgtgaa     9600

aggtccgtga gccgcatgac tgcagagagt gccgtaactg gtctctctgc agatcatgt      9659


<210>  45
<211>  9659
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  45
gcccgccccc tgatgggggc gacactccgc catgaatcac tcccctgtga ggaactactg       60

tcttcacgca gaaagcgtct agccatggcg ttagtatgag tgtcgtacag cctccaggcc      120

cccccctccc gggagagcca tagtggtctg cggaaccggt gagtacaccg gaattaccgg      180

aaagactggg tcctttcttg gataaaccca ctctatgtcc ggtcatttgg gcacgccccc      240

gcaagactgc tagccgagta gcgttgggtt gcgaaaggcc ttgtggtact gcctgatagg      300

gtgcttgcga gtgccccggg aggtctcgta gaccgtgcat catgagcaca aatcctaaac      360

ctcaaagaaa aaccaaaaga aacacaaacc gccgcccaca ggacgttaag ttcccgggtg      420

gcggtcagat cgttggcgga gtttacttgc tgccgcgcag gggccccagg ttgggtgtgc      480

gcgcgacaag gaagacttct gagcgatccc agccgcgtgg acgacgccag cccatcccga      540

aagatcggcg ctccaccggc aagtcctggg gaaagccagg atatccttgg cccctgtacg      600

gaaacgaggg ttgcggctgg gcgggttggc tcctgtcccc ccgcgggtct cgtcctactt      660

ggggccccac cgacccccgg catagatcac gcaatttggg cagagtcatc gataccatta      720

cgtgtggttt tgccgacctc atggggtaca tccctgtcgt tggcgccccg gttggaggcg      780

tcgccagagc tctggcacac ggtgttaggg tcctggagga cgggataaat tacgcaacag      840

ggaatttacc cggttgctct ttttctatct ttttgcttgc tcttctgtca tgcgtcacag      900

tgccagtgtc tgcagtggaa gtcaggaaca ttagttctag ctactacgcc actaatgatt      960

gctcaaacaa cagcatcacc tggcagctca ctgacgcagt tctccatctt cctggatgcg     1020

tcccatgtga gaatgataat ggcaccttgc attgctggat acaagtaaca cccaacgtgg     1080

ctgtgaaaca ccgcggtgcg ctcactcgta gcctgcgaac acacgtcgac atgatcgtaa     1140

tggcagctac ggcctgctcg gccttgtatg tgggagatgt gtgcggggcc gtgatgattc     1200

tatcgcaggc tttcatggta tcaccacaac gccacaactt cacccaagag tgcaactgtt     1260

ccatctacca aggtcacatc accggccatc gcatggcatg ggacatgatg ctgaactggt     1320

ctccaactct tgccatgatc ctcgcctacg ccgctcgtgt tcccgagatg gtcctcgaaa     1380

ttattttcgg cggccattgg ggtgtggtgt ttggcttggc ctacttctcc atgcaaggag     1440

cgtgggccaa agtcattgcc atcctccttc ttgttgcggg agtggatgca accacctatt     1500

ccagcggcca ggaagcgggt cgtaccgtct tggggttcac taacctcttt acttctggtg     1560

ccaagcagaa cctctattta atcaacacca atggcagctg gcacataaac cggactgccc     1620

tcaattgcaa tgacagctta cagacgggtt tcatggcttc cctgttttac acccacaggt     1680

tcaacagctc tggctgcccc gagcgcttgt cttcctgccg cgggctggac gattttcgca     1740

tcggctgggg aaccttggaa tacgaaaccc acgtcaccaa cgatgaggac atgaggccgt     1800

actgctggca ttaccctccg aggccttgcg gcatcgtccc ggctagaacg gtttgcggac     1860

cggtctattg tttcacccct agccctgttg tcgtgggcac cactgacaag cagggcgtac     1920

ccacctacac ctggggggaa aacgagaccg atgtcttcct gctgaatagc acaagacccc     1980

cgcgaggagc ttggttcggc tgcacttgga tgaacgggac tgggttcact aagacatgcg     2040

gtgcaccacc ttgccgcatt aggaaagact acaacagcac tatcgattta ttgtgcccca     2100

cagactgttt taggaagcac cccgatgcta cctatcttaa gtgtggagca gggccttggt     2160

taactcccag gtgcctggta gactaccctt atagactgtg gcattatccg tgcactgtaa     2220

acttcaccat ctttaaggcg cggatgtatg taggaggggt ggagcatcga ttctccgcag     2280

catgcaactt cacgcgcgga gatcgctgca gactggaaga tagggatagg ggtcagcaga     2340

gtccactgct gcattccact actgagtggg cggtgctccc atgctccttc tctgacctac     2400

cagcactatc cactggccta ttgcacctcc accaaaacat cgtggacgtg cagtaccttt     2460

acggactttc tccggctctg acaagataca tcgtgaagtg ggagtgggtg atcctccttt     2520

tcttgttgtt ggcagacgcc aggatctgtg catgcctttg gatgctcatc atactgggcc     2580

aagccgaagc ggcgcttgag aagctcatca tcttgcactc cgctagtgct gctagtgcca     2640

atggtccgct gtggtttttc atcttcttta cagcggcctg gtacttaaag ggcagggtgg     2700

tccccgtggc cacgtactct gttctcggct tatggtcctt cctcctccta gtcctggcct     2760

taccacagca ggcttatgcc ttggacgctg ctgaacaagg ggaactgggg ctggccatat     2820

tagtaattat atccatcttt actcttaccc cagcatacaa gatcctcctg agccgttcag     2880

tgtggtggct gtcctacatg ctggtcttgg ccgaggccca gattcagcaa tgggttcccc     2940

ccctggaggt ccgagggggg cgtgacggaa tcatctgggt ggctgtcatt ctacacccac     3000

gccttgtgtt tgaggtcacg aaatggttgt tagcaatcct ggggcctgcc tacctcctta     3060

aagcgtctct gctacggata ccgtactttg tgagggccca cgctttgcta cgagtgtgta     3120

ccctggtgaa acacctcgcg ggggctaggt acatccagat gctgttgatc accataggca     3180

gatggaccgg cacttacatc tacgaccacc tctccccttt atcaacttgg gcggcccagg     3240

gtttgcggga cctggcaatc gccgtggagc ctgtggtgtt cagcccaatg gagaagaagg     3300

tcattgtgtg gggggctgag acagtggcgt gtggagacat cctgcatggc ctcccggtct     3360

ccgcgaggct aggtagggag gttctgctcg gccctgccga cggctacacc tccaaggggt     3420

ggaagctcct agctcccatt actgcttaca ctcagcaaac tcgtggtctc ctgggtgcta     3480

tcgtggtcag cctaacgggc cgcgacaaaa atgagcaggc tgggcaggtc caggttctgt     3540

cctccgtcac acaaactttc ttggggacat ccatttcggg cgtcctctgg acagtatatc     3600

acggggctgg taataagacc ttggccggcc ccaagggacc agtcactcag atgtacacca     3660

gcgcagaagg ggacctcgtg ggatggccta gtccccccgg gactaagtca ttggacccct     3720

gtacctgcgg ggccgtagac ctctacctgg tcacccgaaa cgctgatgtc attccggtcc     3780

ggaggaaaga tgaccgacgg ggtgcattac tctcgccaag gcccctctca accctcaaag     3840

gatcatccgg agggcccgtg ctctgctcaa ggggacacgc cgtgggcttg ttcagagcgg     3900

ccgtgtgtgc caggggtgta gccaaatcta ttgacttcat ccccgtcgaa tcactcgatg     3960

tcaccacacg gacgcccagt ttctctgaca acagtacgcc gccagctgtg ccccagtctt     4020

accaggtggg ttacttgcac gcaccaacag gcagcggaaa gagcaccaag gtccctgccg     4080

cgtatgccag tcaggggtat aaagtactcg tactaaatcc ctctgtcgcg gccacacttg     4140

gttttggggc ctacatgtcc aaagcccacg ggatcaaccc taatatcaga actggagtgc     4200

ggaccgttac caccggggac tctatcactt actccactta tggcaagttt atcgcagatg     4260

gaggctgtgc agccggtgcc tatgacatca tcatatgcga cgaatgccat tcagtggacg     4320

ctactaccat ccttggcatt ggaacagtcc ttgaccaagc tgagaccgca ggcgtcaggc     4380

tagtggtttt ggccacagcc acgcctcccg gtacggtgac aactccccac agtaacatag     4440

aggaggtggc ccttggtcac gagggcgaga tcccttttta tggcaaagcc attcccctag     4500

ctttcatcaa ggggggcaga cacttgatct tttgccattc aaagaagaag tgcgacgagc     4560

tcgcagcggc cctccggggc atgggtgtca atgccgttgc atactatagg ggtctcgacg     4620

tctccgttat accaactcaa ggagacgtgg tggttgtcgc cactgatgcc ctaatgactg     4680

ggtacaccgg cgactttgac tctgtcatcg actgtaatgt tgcagtctct cagattgttg     4740

acctcagcct agacccaacc ttcaccatca ccactcaaat cgtccctcag gacgctgtct     4800

cccgtagtca acgtagaggg agaactggga gggggcgatt gggcgtttac aggtatgttt     4860

cgtcaggcga aaggccgtct gggatgttcg acagcgtagt gctctgcgag tgctatgatg     4920

ccggggcagc ctggtacgag cttacacctg ctgagactac ggtgagactc cgggcttatt     4980

tcaacacgcc cggtttgccc gtatgtcaag accacctgga gttctgggaa gcggtcttta     5040

caggtctcac acacattgac gcccacttcc tctcccagac gaagcaagga ggagaaaact     5100

ttgcgtatct aacggcctac caggccacag tatgcgccag ggcaaaggcc cctcctcctt     5160

cgtgggacgt gatgtggaag tgtctaacta ggctcaaacc tacactgact ggtcccaccc     5220

ccctcctgta ccgcttgggt gccgtgacca atgaggtcac cttgacgcac cccgtgacga     5280

aatacatcgc cacgtgcatg caagctgacc tcgagatcat gacaagctca tgggtcctgg     5340

cggggggggt gctagccgcc gtggcatctt actgcctggc gactggctgc atttccatca     5400

ttggccgcct acacctgaat gatcgggtgg ttgtggcccc cgacaaggaa atcttatatg     5460

aggcctttga tgagatggaa gaatgcgcct ccaaagccgc cctcattgag gaagggcagc     5520

ggatggcgga gatgctcaaa tctaagatac aaggcctcct acaacaggcc acaaggcaag     5580

ctcaagacat acagccagct atacagtcat catggcccaa gcttgaacaa ttttgggcca     5640

aacacatgtg gaacttcatc agtggtatac agtacctagc aggactctcc accctaccgg     5700

gaaatcctgc agtagcatca atgatggctt ttagcgccgc gctgactagc ccactaccca     5760

ccagcaccac catcctcttg aacatcatgg gaggatggtt ggcctctcag attgcccccc     5820

ctgccggagc cactggcttc gttgtcagtg gtctagtggg ggcggccgtc ggaagcatag     5880

gcctgggtaa gatactggtg gacgttttgg ccgggtacgg cgcaggcatt tcaggggccc     5940

tcgtagcttt taagatcatg agcggcgaga agcccacggt agaagacgtt gtgaatctcc     6000

tgcctgctat tctgtctcct ggtgcgttgg tagtgggagt catctgtgca gcaatcctgc     6060

gccgccacgt cggtcaggga gagggggcgg tccagtggat gaacagactg atcgccttcg     6120

cctccagggg aaaccacgtt gcccctaccc actacgtggt ggagtctgac gcttcacagc     6180

gtgtaacgca ggtgctgagt tcacttacaa ttaccagctt acttaggaga ctacatgcct     6240

ggatcactga agattgccca gtcccatgct cggggtcttg gctccaggac atttgggatt     6300

gggtttgttc catcctcaca gacttcaaaa actggctgtc ttcaaaatta ctccccaaga     6360

tgcccggcat tccctttatc tcttgccaga agggatacaa gggtgtatgg gctggtacgg     6420

gtgtcatgac tactcggtgc ccatgtggag caaacatctc gggccatgtc cgcatgggca     6480

ccatgaaaat aacaggcccg aagacttgct tgaacctgtg gcaggggact ttccccatta     6540

attgttacac agaagggcct tgcgtgccaa aaccccctcc taattacaag accgcaattt     6600

ggagggtggc agcgtcggag tacgttgagg tcacacagca tggctctttc tcgtatgtaa     6660

cagggttaac cagtgacaac cttaaggtcc cttgccaggt accagctcca gaatttttct     6720

cttgggtgga cggggtgcaa atccaccgat tcgcccccgt tccaggtccc ttctttcggg     6780

atgaggtaac gttcaccgta ggccttaact ccttcgtggt cggctctcag ctcccttgcg     6840

atcctgagcc ggacaccgag gtactggcct ccatgttgac agacccgtcc cacatcaccg     6900

cggaggcggc agccaggcga ttggcaaggg gatctccccc ttcacaggct agctcctcag     6960

cgagccagct ctctgccccg tccttgaagg ctacctgtac cacccataag acagcatatg     7020

attgtgacat ggtggatgcc aaccttttca tgggaggcga tgtgacccgg attgagtctg     7080

actctaaggt gatcgttctc gactccctcg attccatgac tgaggtagag gatgatcgtg     7140

agccttctgt accatcagag tacctgatca agaggagaaa gttcccaccg gcgctgcctc     7200

cttgggcccg tccagactac aatcctgttt tgatcgagac atggaagagg ccgggctatg     7260

aaccacccac tgtcctaggc tgtgccctcc cccccacacc tcaaacgcca gtgcctccac     7320

ctcggaggcg ccgcgccaaa gtcctgaccc aggacaatgt ggaggggatc ctcagggaga     7380

tggctgacaa agtactcagc cctctccaag acaacaatga ctccggtcac tccactggag     7440

cggataccgg aggagacatc gtccagcaac cctctgacga gactgccgct tcagaagcgg     7500

ggtcactgtc ctccatgcct ccccttgagg gagagccggg agaccctgac ctggagtttg     7560

aaccagtggg atccgctccc ccttctgagg gggagtgtga ggtcattgat tcggactcta     7620

agtcgtggtc cacagtctct gatcaagagg attctgttat ctgctgctct atgtcatact     7680

cctggacggg ggccctcata acaccatgtg ggcccgaaga ggagaagtta ccgatcaacc     7740

ctctgagtaa ttcgctcatg cggttccata ataaggtgta ctccacaacc tcgaggagtg     7800

cctctctgag ggcaaagaag gtgacttttg acagggtgca ggtgctggac gcacactatg     7860

actcagtctt gcaggacgtt aagcgggccg cctctaaggt tagtgcgagg ctcctcacgg     7920

tagaggaagc ctgcgcgctg accccgcccc actccgccaa atcgcgatac ggatttgggg     7980

caaaagaggt gcgcagctta tccaggaggg ccgttaacca catccggtcc gtgtgggagg     8040

acctcctgga agaccaacat accccaattg acacaactat catggctaaa aatgaggtgt     8100

tctgcattga tccaactaaa ggtgggaaaa agccagctcg cctcatcgta taccccgacc     8160

ttggggtcag ggtgtgcgaa aagatggccc tctatgacat cgcacaaaag cttcccaaag     8220

cgataatggg gccatcctat gggttccaat actctcccgc agaacgggtc gatttcctcc     8280

tcaaagcttg gggaagtaag aaggacccaa tggggttctc gtatgacacc cgctgctttg     8340

actcaaccgt cacggagagg gacataagaa cagaagaatc catatatcag gcttgttctc     8400

tgcctcaaga agccagaact gtcatacact cgctcactga gagactttac gtaggagggc     8460

ccatgacaaa cagcaaaggg caatcctgcg gctacaggcg ttgccgcgca agcggtgttt     8520

tcaccaccag catggggaat accatgacat gttacatcaa agcccttgca gcgtgtaagg     8580

ctgcagggat cgtggaccct gttatgttgg tgtgtggaga cgacctggtc gtcatctcag     8640

agagccaagg taacgaggag gacgagcgaa acctgagagc tttcacggag gctatgacca     8700

ggtattccgc ccctcccggt gaccttccca gaccggaata tgacttggag cttataacat     8760

cctgctcctc aaacgtatcg gtagcgctgg actctcgggg tcgccgccgg tacttcctaa     8820

ccagagaccc taccactcca atcacccgag ctgcttggga aacagtaaga cactcccctg     8880

tcaattcttg gctgggcaac atcatccagt acgcccccac aatctgggtc cggatggtca     8940

taatgactca cttcttctcc atactattgg cccaggacac tctgaaccaa aatctcaatt     9000

ttgagatgta cggggcagta tactcggtca atccattaga cctaccggcc ataattgaaa     9060

ggctacatgg gcttgaagcc ttttcactgc acacatactc tccccgcgaa ctctcacggg     9120

tggcagcaac tctcagaaaa cttggagcgc ctccccttag agcgtggaag agtcgggcgc     9180

gtgccgtgag agcttcactc atcgcccaag gagcgagggc ggccatttgt ggccgctacc     9240

tcttcaactg ggcggtgaaa acaaagctca aactcactcc attgcccgag gcgagccgcc     9300

tggatttatc cgggtggttc accgtgggcg ccggcggggg cggcatttat cacagcgtgt     9360

cgcatgcccg accccgccta ttactccttt gcctactcct acttagcgta ggagtaggca     9420

tctttttact ccccgctcgg tagagcggca aaccctagct acactccata gctagtttcc     9480

gttttttttt ttttgttttt tttttttttt tttttttttt tttttttttt tttcttttcc     9540

tttttttttt ttctctttct tggtggctcc atcttagccc tagtcacggc tagctgtgaa     9600

aggtccgtga gccgcatgac tgcagagagt gccgtaactg gtctctctgc agatcatgt      9659


<210>  46
<211>  9659
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  46
gcccgccccc tgatgggggc gacactccgc catgaatcac tcccctgtga ggaactactg       60

tcttcacgca gaaagcgtct agccatggcg ttagtatgag tgtcgtacag cctccaggcc      120

cccccctccc gggagagcca tagtggtctg cggaaccggt gagtacaccg gaattaccgg      180

aaagactggg tcctttcttg gataaaccca ctctatgtcc ggtcatttgg gcacgccccc      240

gcaagactgc tagccgagta gcgttgggtt gcgaaaggcc ttgtggtact gcctgatagg      300

gtgcttgcga gtgccccggg aggtctcgta gaccgtgcat catgagcaca aatcctaaac      360

ctcaaagaaa aaccaaaaga aacacaaacc gccgcccaca ggacgttaag ttcccgggtg      420

gcggtcagat cgttggcgga gtttacttgc tgccgcgcag gggccccagg ttgggtgtgc      480

gcgcgacaag gaagacttct gagcgatccc agccgcgtgg acgacgccag cccatcccga      540

aagatcggcg ctccaccggc aagtcctggg gaaagccagg atatccttgg cccctgtacg      600

gaaacgaggg ttgcggctgg gcgggttggc tcctgtcccc ccgcgggtct cgtcctactt      660

ggggccccac cgacccccgg catagatcac gcaatttggg cagagtcatc gataccatta      720

cgtgtggttt tgccgacctc atggggtaca tccctgtcgt tggcgccccg gttggaggcg      780

tcgccagagc tctggcacac ggtgttaggg tcctggagga cgggataaat tacgcaacag      840

ggaatttacc cggttgctct ttttctatct ttttgcttgc tcttctgtca tgcgtcacag      900

tgccagtgtc tgcagtggaa gtcaggaaca ttagttctag ctactacgcc actaatgatt      960

gctcaaacaa cagcatcacc tggcagctca ctgacgcagt tctccatctt cctggatgcg     1020

tcccatgtga gaatgataat ggcaccttgc attgctggat acaagtaaca cccaacgtgg     1080

ctgtgaaaca ccgcggtgcg ctcactcgta gcctgcgaac acacgtcgac atgatcgtaa     1140

tggcagctac ggcctgctcg gccttgtatg tgggagatgt gtgcggggcc gtgatgattc     1200

tatcgcaggc tttcatggta tcaccacaac gccacaactt cacccaagag tgcaactgtt     1260

ccatctacca aggtcacatc accggccatc gcatggcatg ggacatgatg ctgaactggt     1320

ctccaactct tgccatgatc ctcgcctacg ccgctcgtgt tcccgagatg gtcctcgaaa     1380

ttattttcgg cggccattgg ggtgtggtgt ttggcttggc ctacttctcc atgcaaggag     1440

cgtgggccaa agtcattgcc atcctccttc ttgttgcggg agtggatgca accacctatt     1500

ccagcggcca ggaagcgggt cgtaccgtct tggggttcac taacctcttt acttctggtg     1560

ccaagcagaa cctctattta atcaacacca atggcagctg gcacataaac cggactgccc     1620

tcaattgcaa tgacagctta cagacgggtt tcatggcttc cctgttttac acccacaggt     1680

tcaacagctc tggctgcccc gagcgcttgt cttcctgccg cgggctggac gattttcgca     1740

tcggctgggg aaccttggaa tacgaaaccc acgtcaccaa cgatgaggac atgaggccgt     1800

actgctggca ttaccctccg aggccttgcg gcatcgtccc ggctagaacg gtttgcggac     1860

cggtctattg tttcacccct agccctgttg tcgtgggcac cactgacaag cagggcgtac     1920

ccacctacac ctggggggaa aacgagaccg atgtcttcct gctgaatagc acaagacccc     1980

cgcgaggagc ttggttcggc tgcacttgga tgaacgggac tgggttcact aagacatgcg     2040

gtgcaccacc ttgccgcatt aggaaagact acaacagcac tatcgattta ttgtgcccca     2100

cagactgttt taggaagcac cccgatgcta cctatcttaa gtgtggagca gggccttggt     2160

taactcccag gtgcctggta gactaccctt atagactgtg gcattatccg tgcactgtaa     2220

acttcaccat ctttaaggcg cggatgtatg taggaggggt ggagcatcga ttctccgcag     2280

catgcaactt cacgcgcgga gatcgctgca gactggaaga tagggatagg ggtcagcaga     2340

gtccactgct gcattccact actgagtggg cggtgctccc atgctccttc tctgacctac     2400

cagcactatc cactggccta ttgcacctcc accaaaacat cgtggacgtg cagtaccttt     2460

acggactttc tccggctctg acaagataca tcgtgaagtg ggagtgggtg atcctccttt     2520

tcttgttgtt ggcagacgcc aggatctgtg catgcctttg gatgctcatc atactgggcc     2580

aagccgaagc ggcgcttgag aagctcatca tcttgcactc cgctagtgct gctagtgcca     2640

atggtccgct gtggtttttc atcttcttta cagcggcctg gtacttaaag ggcagggtgg     2700

tccccgtggc cacgtactct gttctcggct tatggtcctt cctcctccta gtcctggcct     2760

taccacagca ggcttatgcc ttggacgctg ctgaacaagg ggaactgggg ctggccatat     2820

tagtaattat atccatcttt actcttaccc cagcatacaa gatcctcctg agccgttcag     2880

tgtggtggct gtcctacatg ctggtcttgg ccgaggccca gattcagcaa tgggttcccc     2940

ccctggaggt ccgagggggg cgtgacggaa tcatctgggt ggctgtcatt ctacacccac     3000

gccttgtgtt tgaggtcacg aaatggttgt tagcaatcct ggggcctgcc tacctcctta     3060

aagcgtctct gctacggata ccgtactttg tgagggccca cgctttgcta cgagtgtgta     3120

ccctggtgaa acacctcgcg ggggctaggt acatccagat gctgttgatc accataggca     3180

gatggaccgg cacttacatc tacgaccacc tctccccttt atcaacttgg gcggcccagg     3240

gtttgcggga cctggcaatc gccgtggagc ctgtggtgtt cagcccaatg gagaagaagg     3300

tcattgtgtg gggggctgag acagtggcgt gtggagacat cctgcatggc ctcccggtct     3360

ccgcgaggct aggtagggag gttctgctcg gccctgccga cggctacacc tccaaggggt     3420

ggaagctcct agctcccatt actgcttaca ctcagcaaac tcgtggtctc ctgggtgcta     3480

tcgtggtcag cctaacgggc cgcgacaaaa atgagcaggc tgggcaggtc caggttctgt     3540

cctccgtcac acaaactttc ttggggacat ccatttcggg cgtcctctgg acagtatatc     3600

acggggctgg taataagacc ttggccggcc ccaagggacc agtcactcag atgtacacca     3660

gcgcagaagg ggacctcgtg ggatggccta gtccccccgg gactaagtca ttggacccct     3720

gtacctgcgg ggccgtagac ctctacctgg tcacccgaaa cgctgatgtc attccggtcc     3780

ggaggaaaga tgaccgacgg ggtgcattac tctcgccaag gcccctctca accctcaaag     3840

gatcatccgg agggcccgtg ctctgctcaa ggggacacgc cgtgggcttg ttcagagcgg     3900

ccgtgtgtgc caggggtgta gccaaatcta ttgacttcat ccccgtcgaa tcactcgatg     3960

tcgccacacg gacgcccagt ttctctgaca acagtacgcc gccagctgtg ccccagtctt     4020

accaggtggg ttacttgcac gcaccaacag gcagcggaaa gagcaccaag gtccctgccg     4080

cgtatgccag tcaggggtat aaagtactcg tactaaatcc ctctgtcgcg gccacacttg     4140

gttttggggc ctacatgtcc aaagcccacg ggatcaaccc taatatcaga actggagtgc     4200

ggaccgttac caccggggac tctatcactt actccactta tggcaagttt atcgcagatg     4260

gaggctgtgc agccggtgcc tatgacatca tcatatgcga cgaatgccat tcagtggacg     4320

ctactaccat ccttggcatt ggaacagtcc ttgaccaagc tgagaccgca ggcgtcaggc     4380

tagtggtttt ggccacagcc acgcctcccg gtacggtgac aactccccac agtaacatag     4440

aggaggtggc ccttggtcac gagggcgaga tcccttttta tggcaaagcc attcccctag     4500

ctttcatcaa ggggggcaga cacttgatct tttgccattc aaagaagaag tgcgacgagc     4560

tcgcagcggc cctccggggc atgggtgtca atgccgttgc atactatagg ggtctcgacg     4620

tctccgttat accaactcaa ggagacgtgg tggttgtcgc cactgatgcc ctaatgactg     4680

ggtacaccgg cgactttgac tctgtcatcg actgtaatgt tgcagtctct cagattgttg     4740

acctcagcct agacccaacc ttcaccatca ccactcaaat cgtccctcag gacgctgtct     4800

cccgtagtca acgtagaggg agaactggga gggggcgatt gggcgtttac aggtatgttt     4860

cgtcaggcga aaggccgtct gggatgttcg acagcgtagt gctctgcgag tgctatgatg     4920

ccggggcagc ctggtacgag cttacacctg ctgagactac ggtgagactc cgggcttatt     4980

tcaacacgcc cggtttgccc gtatgtcaag accacctgga gttctgggaa gcggtcttta     5040

caggtctcac acacattgac gcccacttcc tctcccagac gaagcaagga ggagaaaact     5100

ttgcgtatct aacggcctac caggccacag tatgcgccag ggcaaaggcc cctcctcctt     5160

cgtgggacgt gatgtggaag tgtctaacta ggctcaaacc tacactgact ggtcccaccc     5220

ccctcctgta ccgcttgggt gccgtgacca atgaggtcac cttgacgcac cccgtgacga     5280

aatacatcgc cacgtgcatg caagctgacc tcgagatcat gacaagctca tgggtcctgg     5340

cggggggggt gctagccgcc gtggcatctt actgcctggc gactggctgc atttccatca     5400

ttggccgcct acacctgaat gatcgggtgg ttgtggcccc cgacaaggaa atcttatatg     5460

aggcctttga tgagatggaa gaatgcgcct ccaaagccgc cctcattgag gaagggcagc     5520

ggatggcgga gatgctcaaa tctaagatac aaggcctcct acaacaggcc acaaggcaag     5580

ctcaagacat acagccagct atacagtcat catggcccaa gcttgaacaa ttttgggcca     5640

aacacatgtg gaacttcatc agtggtatac agtacctagc aggactctcc accctaccgg     5700

gaaatcctgc agtagcatca atgatggctt ttagcgccgc gctgactagc ccactaccca     5760

ccagcaccac catcctcttg aacatcatgg gaggatggtt ggcctctcag attgcccccc     5820

ctgccggagc cactggcttc gttgtcagtg gtctagtggg ggcggccgtc ggaagcatag     5880

gcctgggtaa gatactggtg gacgttttgg ccgggtacgg cgcaggcatt tcaggggccc     5940

tcgtagcttt taagatcatg agcggcgaga agcccacggt agaagacgtt gtgaatctcc     6000

tgcctgctat tctgtctcct ggtgcgttgg tagtgggagt catctgtgca gcaatcctgc     6060

gccgccacgt cggtcaggga gagggggcgg tccagtggat gaacagactg atcgccttcg     6120

cctccagggg aaaccacgtt gcccctaccc actacgtggt ggagtctgac gcttcacagc     6180

gtgtaacgca ggtgctgagt tcacttacaa ttaccagctt acttaggaga ctacatgcct     6240

gggtcactga agattgccca gtcccatgct cggggtcttg gctccaggac atttgggatt     6300

gggtttgttc catcctcaca gacttcaaaa actggctgtc ttcaaaatta ctccccaaga     6360

tgcccggcat tccctttatc tcttgccaga agggatacaa gggtgtatgg gctggtacgg     6420

gtgtcatgac tactcggtgc ccatgtggag caaacatctc gggccatgtc cgcatgggca     6480

ccatgaaaat aacaggcccg aagacttgct tgaacctgtg gcaggggact ttccccatta     6540

attgttacac agaagggcct tgcgtgccaa aaccccctcc taattacaag accgcaattt     6600

ggagggtggc agcgtcggag tacgttgagg tcacacagca tggctctttc tcgtatgtaa     6660

cagggttaac cagtgacaac cttaaggtcc cttgccaggt accagctcca gaatttttct     6720

cttgggtgga cggggtgcaa atccaccgat tcgcccccgt tccaggtccc ttctttcggg     6780

atgaggtaac gttcaccgta ggccttaact ccttcgtggt cggctctcag ctcccttgcg     6840

atcctgagcc ggacaccgag gtactggcct ccatgttgac agacccgtcc cacatcaccg     6900

cggaggcggc agccaggcga ttggcaaggg gatctccccc ttcacaggct agctcctcag     6960

cgagccagct ctctgccccg tccttgaagg ctacctgtac cacccataag acagcatatg     7020

attgtgacat ggtggatgcc aaccttttca tgggaggcga tgtgacccgg attgagtctg     7080

actctaaggt gatcgttctc gactccctcg attccatgac tgaggtagag gatgatcgtg     7140

agccttctgt accatcagag tacctgatca agaggagaaa gttcccaccg gcgctgcctc     7200

cttgggcccg tccagactac aatcctgttt tgatcgagac atggaagagg ccgggctatg     7260

aaccacccac tgtcctaggc tgtgccctcc cccccacacc tcaaacgcca gtgcctccac     7320

ctcggaggcg ccgcgccaaa gtcctgaccc aggacaatgt ggaggggatc ctcagggaga     7380

tggctgacaa agtactcagc cctctccaag acaacaatga ctccggtcac tccactggag     7440

cggataccgg aggagacatc gtccagcaac cctctgacga gactgccgct tcagaagcgg     7500

ggtcactgtc ctccatgcct ccccttgagg gagagccggg agaccctgac ctggagtttg     7560

aaccagtggg atccgctccc ccttctgagg gggagtgtga ggtcattgat tcggactcta     7620

agtcgtggtc cacagtctct gatcaagagg attctgttat ctgctgctct atgtcatact     7680

cctggacggg ggccctcata acaccatgtg ggcccgaaga ggagaagtta ccgatcaacc     7740

ctctgagtaa ttcgctcatg cggttccata ataaggtgta ctccacaacc tcgaggagtg     7800

cctctctgag ggcaaagaag gtgacttttg acagggtgca ggtgctggac gcacactatg     7860

actcagtctt gcaggacgtt aagcgggccg cctctaaggt tagtgcgagg ctcctcacgg     7920

tagaggaagc ctgcgcgctg accccgcccc actccgccaa atcgcgatac ggatttgggg     7980

caaaagaggt gcgcagctta tccaggaggg ccgttaacca catccggtcc gtgtgggagg     8040

acctcctgga agaccaacat accccaattg acacaactat catggctaaa aatgaggtgt     8100

tctgcattga tccaactaaa ggtgggaaaa agccagctcg cctcatcgta taccccgacc     8160

ttggggtcag ggtgtgcgaa aagatggccc tctatgacat cgcacaaaag cttcccaaag     8220

cgataatggg gccatcctat gggttccaat actctcccgc agaacgggtc gatttcctcc     8280

tcaaagcttg gggaagtaag aaggacccaa tggggttctc gtatgacacc cgctgctttg     8340

actcaaccgt cacggagagg gacataagaa cagaagaatc catatatcag gcttgttctc     8400

tgcctcaaga agccagaact gtcatacact cgctcactga gagactttac gtaggagggc     8460

ccatgacaaa cagcaaaggg caatcctgcg gctacaggcg ttgccgcgca agcggtgttt     8520

tcaccaccag catggggaat accatgacat gttacatcaa agcccttgca gcgtgtaagg     8580

ctgcagggat cgtggaccct gttatgttgg tgtgtggaga cgacctggtc gtcatctcag     8640

agagccaagg taacgaggag gacgagcgaa acctgagagc tttcacggag gctatgacca     8700

ggtattccgc ccctcccggt gaccttccca gaccggaata tgacttggag cttataacat     8760

cctgctcctc aaacgtatcg gtagcgctgg actctcgggg tcgccgccgg tacttcctaa     8820

ccagagaccc taccactcca atcacccgag ctgcttggga aacagtaaga cactcccctg     8880

tcaattcttg gctgggcaac atcatccagt acgcccccac aatctgggtc cggatggtca     8940

taatgactca cttcttctcc atactattgg cccaggacac tctgaaccaa aatctcaatt     9000

ttgagatgta cggggcagta tactcggtca atccattaga cctaccggcc ataattgaaa     9060

ggctacatgg gcttgaagcc ttttcactgc acacatactc tccccgcgaa ctctcacggg     9120

tggcagcaac tctcagaaaa cttggagcgc ctccccttag agcgtggaag agtcgggcgc     9180

gtgccgtgag agcttcactc atcgcccaag gagcgagggc ggccatttgt ggccgctacc     9240

tcttcaactg ggcggtgaaa acaaagctca aactcactcc attgcccgag gcgagccgcc     9300

tggatttatc cgggtggttc accgtgggcg ccggcggggg cggcatttat cacagcgtgt     9360

cgcatgcccg accccgccta ttactccttt gcctactcct acttagcgta ggagtaggca     9420

tctttttact ccccgctcgg tagagcggca aaccctagct acactccata gctagtttcc     9480

gttttttttt ttttgttttt tttttttttt tttttttttt tttttttttt tttcttttcc     9540

tttttttttt ttctctttct tggtggctcc atcttagccc tagtcacggc tagctgtgaa     9600

aggtccgtga gccgcatgac tgcagagagt gccgtaactg gtctctctgc agatcatgt      9659


<210>  47
<211>  9659
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  47
gcccgccccc tgatgggggc gacactccgc catgaatcac tcccctgtga ggaactactg       60

tcttcacgca gaaagcgtct agccatggcg ttagtatgag tgtcgtacag cctccaggcc      120

cccccctccc gggagagcca tagtggtctg cggaaccggt gagtacaccg gaattaccgg      180

aaagactggg tcctttcttg gataaaccca ctctatgtcc ggtcatttgg gcacgccccc      240

gcaagactgc tagccgagta gcgttgggtt gcgaaaggcc ttgtggtact gcctgatagg      300

gtgcttgcga gtgccccggg aggtctcgta gaccgtgcat catgagcaca aatcctaaac      360

ctcaaagaaa aaccaaaaga aacacaaacc gccgcccaca ggacgttaag ttcccgggtg      420

gcggtcagat cgttggcgga gtttacttgc tgccgcgcag gggccccagg ttgggtgtgc      480

gcgcgacaag gaagacttct gagcgatccc agccgcgtgg acgacgccag cccatcccga      540

aagatcggcg ctccaccggc aagtcctggg gaaagccagg atatccttgg cccctgtacg      600

gaaacgaggg ttgcggctgg gcgggttggc tcctgtcccc ccgcgggtct cgtcctactt      660

ggggccccac cgacccccgg catagatcac gcaatttggg cagagtcatc gataccatta      720

cgtgtggttt tgccgacctc atggggtaca tccctgtcgt tggcgccccg gttggaggcg      780

tcgccagagc tctggcacac ggtgttaggg tcctggagga cgggataaat tacgcaacag      840

ggaatttacc cggttgctct ttttctatct ttttgcttgc tcttctgtca tgcgtcacag      900

tgccagtgtc tgcagtggaa gtcaggaaca ttagttctag ctactacgcc actaatgatt      960

gctcaaacaa cagcatcacc tggcagctca ctgacgcagt tctccatctt cctggatgcg     1020

tcccatgtga gaatgataat ggcaccttgc attgctggat acaagtaaca cccaacgtgg     1080

ctgtgaaaca ccgcggtgcg ctcactcgta gcctgcgaac acacgtcgac atgatcgtaa     1140

tggcagctac ggcctgctcg gccttgtatg tgggagatgt gtgcggggcc gtgatgattc     1200

tatcgcaggc tttcatggta tcaccacaac gccacaactt cacccaagag tgcaactgtt     1260

ccatctacca aggtcacatc accggccatc gcatggcatg ggacatgatg ctgaactggt     1320

ctccaactct tgccatgatc ctcgcctacg ccgctcgtgt tcccgagatg gtcctcgaaa     1380

ttattttcgg cggccattgg ggtgtggtgt ttggcttggc ctacttctcc atgcaaggag     1440

cgtgggccaa agtcattgcc atcctccttc ttgttgcggg agtggatgca accacctatt     1500

ccagcggcca ggaagcgggt cgtaccgtct tggggttcac taacctcttt acttctggtg     1560

ccaagcagaa cctctattta atcaacacca atggcagctg gcacataaac cggactgccc     1620

tcaattgcaa tgacagctta cagacgggtt tcatggcttc cctgttttac acccacaggt     1680

tcaacagctc tggctgcccc gagcgcttgt cttcctgccg cgggctggac gattttcgca     1740

tcggctgggg aaccttggaa tacgaaaccc acgtcaccaa cgatgaggac atgaggccgt     1800

actgctggca ttaccctccg aggccttgcg gcatcgtccc ggctagaacg gtttgcggac     1860

cggtctattg tttcacccct agccctgttg tcgtgggcac cactgacaag cagggcgtac     1920

ccacctacac ctggggggaa aacgagaccg atgtcttcct gctgaatagc acaagacccc     1980

cgcgaggagc ttggttcggc tgcacttgga tgaacgggac tgggttcact aagacatgcg     2040

gtgcaccacc ttgccgcatt aggaaagact acaacagcac tatcgattta ttgtgcccca     2100

cagactgttt taggaagcac cccgatgcta cctatcttaa gtgtggagca gggccttggt     2160

taactcccag gtgcctggta gactaccctt atagactgtg gcattatccg tgcactgtaa     2220

acttcaccat ctttaaggcg cggatgtatg taggaggggt ggagcatcga ttctccgcag     2280

catgcaactt cacgcgcgga gatcgctgca gactggaaga tagggatagg ggtcagcaga     2340

gtccactgct gcattccact actgagtggg cggtgctccc atgctccttc tctgacctac     2400

cagcactatc cactggccta ttgcacctcc accaaaacat cgtggacgtg cagtaccttt     2460

acggactttc tccggctctg acaagataca tcgtgaagtg ggagtgggtg atcctccttt     2520

tcttgttgtt ggcagacgcc aggatctgtg catgcctttg gatgctcatc atactgggcc     2580

aagccgaagc ggcgcttgag aagctcatca tcttgcactc cgctagtgct gctagtgcca     2640

atggtccgct gtggtttttc atcttcttta cagcggcctg gtacttaaag ggcagggtgg     2700

tccccgtggc cacgtactct gttctcggct tatggtcctt cctcctccta gtcctggcct     2760

taccacagca ggcttatgcc ttggacgctg ctgaacaagg ggaactgggg ctggccatat     2820

tagtaattat atccatcttt actcttaccc cagcatacaa gatcctcctg agccgttcag     2880

tgtggtggct gtcctacatg ctggtcttgg ccgaggccca gattcagcaa tgggttcccc     2940

ccctggaggt ccgagggggg cgtgacggaa tcatctgggt ggctgtcatt ctacacccac     3000

gccttgtgtt tgaggtcacg aaatggttgt tagcaatcct ggggcctgcc tacctcctta     3060

aagcgtctct gctacggata ccgtactttg tgagggccca cgctttgcta cgagtgtgta     3120

ccctggtgaa acacctcgcg ggggctaggt acatccagat gctgttgatc accataggca     3180

gatggaccgg cacttacatc tacgaccacc tctccccttt atcaacttgg gcggcccagg     3240

gtttgcggga cctggcaatc gccgtggagc ctgtggtgtt cagcccaatg gagaagaagg     3300

tcattgtgtg gggggctgag acagtggcgt gtggagacat cctgcatggc ctcccggtct     3360

ccgcgaggct aggtagggag gttctgctcg gccctgccga cggctacacc tccaaggggt     3420

ggaagctcct agctcccatt actgcttaca ctcagcaaac tcgtggtctc ctgggtgcta     3480

tcgtggtcag cctaacgggc cgcgacaaaa atgagcaggc tgggcaggtc caggttctgt     3540

cctccgtcac acaaactttc ttggggacat ccatttcggg cgtcctctgg acagtatatc     3600

acggggctgg taataagacc ttggccggcc ccaagggacc agtcactcag atgtacacca     3660

gcgcagaagg ggacctcgtg ggatggccta gtccccccgg gactaagtca ttggacccct     3720

gtacctgcgg ggccgtagac ctctacctgg tcacccgaaa cgctgatgtc attccggtcc     3780

ggaggaaaga tgaccgacgg ggtgcattac tctcgccaag gcccctctca accctcaaag     3840

gatcatccgg agggcccgtg ctctgctcaa ggggacacgc cgtgggcttg ttcagagcgg     3900

ccgtgtgtgc caggggtgta gccaaatcta ttgacttcat ccccgtcgaa tcactcgatg     3960

tcgccacacg gacgcccagt ttctctgaca acagtacgcc gccagctgtg ccccagtctt     4020

accaggtggg ttacttgcac gcaccaacag gcagcggaaa gagcaccaag gtccctgccg     4080

cgtatgccag tcaggggtat aaagtactcg tactaaatcc ctctgtcgcg gccacacttg     4140

gttttggggc ctacatgtcc aaagcccacg ggatcaaccc taatatcaga actggagtgc     4200

ggaccgttac caccggggac tctatcactt actccactta tggcaagttt atcgcagatg     4260

gaggctgtgc agccggtgcc tatgacatca tcatatgcga cgaatgccat tcagtggacg     4320

ctactaccat ccttggcatt ggaacagtcc ttgaccaagc tgagaccgca ggcgtcaggc     4380

tagtggtttt ggccacagcc acgcctcccg gtacggtgac aactccccac agtaacatag     4440

aggaggtggc ccttggtcac gagggcgaga tcccttttta tggcaaagcc attcccctag     4500

ctttcatcaa ggggggcaga cacttgatct tttgccattc aaagaagaag tgcgacgagc     4560

tcgcagcggc cctccggggc atgggtgtca atgccgttgc atactatagg ggtctcgacg     4620

tctccgttat accaactcaa ggagacgtgg tggttgtcgc cactgatgcc ctaatgactg     4680

ggtacaccgg cgactttgac tctgtcatcg actgtaatgt tgcagtctct cagattgttg     4740

acctcagcct agacccaacc ttcaccatca ccactcaaat cgtccctcag gacgctgtct     4800

cccgtagtca acgtagaggg agaactggga gggggcgatt gggcgtttac aggtatgttt     4860

cgtcaggcga aaggccgtct gggatgttcg acagcgtagt gctctgcgag tgctatgatg     4920

ccggggcagc ctggtacgag cttacacctg ctgagactac ggtgagactc cgggcttatt     4980

tcaacacgcc cggtttgccc gtatgtcaag accacctgga gttctgggaa gcggtcttta     5040

caggtctcac acacattgac gcccacttcc tctcccagac gaagcaagga ggagaaaact     5100

ttgcgtatct aacggcctac caggccacag tatgcgccag ggcaaaggcc cctcctcctt     5160

cgtgggacgt gatgtggaag tgtctaacta ggctcaaacc tacactgact ggtcccaccc     5220

ccctcctgta ccgcttgggt gccgtgacca atgaggtcac cttgacgcac cccgtgacga     5280

aatacatcgc cacgtgcatg caagctgacc tcgagatcat gacaagctca tgggtcctgg     5340

cggggggggt gctagccgcc gtggcatctt actgcctggc gactggctgc atttccatca     5400

ttggccgcct acacctgaat gatcgggtgg ttgtggcccc cgacaaggaa atcttatatg     5460

aggcctttga tgagatggaa gaatgcgcct ccaaagccgc cctcattgag gaagggcagc     5520

ggatggcgga gatgctcaaa tctaagatac aaggcctcct acaacaggcc acaaggcaag     5580

ctcaagacat acagccagct atacagtcat catggcccaa gcttgaacaa ttttgggcca     5640

aacacatgtg gaacttcatc agtggtatac agtacctagc aggactctcc accctaccgg     5700

gaaatcctgc agtagcatca atgatggctt ttagcgccgc gctgactagc ccactaccca     5760

ccagcaccac catcctcttg aacatcatgg gaggatggtt ggcctctcag attgcccccc     5820

ctgccggagc cactggcttc gttgtcagtg gtctagtggg ggcggccgtc ggaagcatag     5880

gcctgggtaa gatactggtg gacgttttgg ccgggtacgg cgcaggcatt tcaggggccc     5940

tcgtagcttt taagatcatg agcggcgaga agcccacggt agaagacgtt gtgaatctcc     6000

tgcctgctat tctgtctcct ggtgcgttgg tagtgggagt catctgtgca gcaatcctgc     6060

gccgccacgt cggtcaggga gagggggcgg tccagtggat gaacagactg atcgccttcg     6120

cctccagggg aaaccacgtt gcccctaccc actacgtggt ggagtctgac gcttcacagc     6180

gtgtaacgca ggtgctgagt tcacttacaa ttaccagctt acttaggaga ctacatgcct     6240

ggatcactga agattgccca gtcccatgct cggggtcttg gctccaggac atttgggatt     6300

gggtttgttc catcctcaca gacttcaaaa actggctgtc ttcaaaatta ctccccaaga     6360

tgcccggcat tccctttatc tcttgccaga agggatacaa gggtgtatgg gctggtacgg     6420

gtgtcatgac tactcggtgc ccatgtggag caaacatctc gggccatgtc cgcatgggca     6480

ccatgaaaat aacaggcccg aagacttgct tgaacctgtg gcaggggact ttccccatta     6540

attgttacac agaagggcct tgcgtgccaa aaccccctcc taattacaag accgcaattt     6600

ggagggtggc agcgtcggag tacgttgagg tcacacagca tggctctttc tcgtatgtaa     6660

cagggttaac cagtgacaac cttaaggtcc cttgccaggt accagctcca gaatttttct     6720

cttgggtgga cggggtgcaa atccaccgat tcgcccccgt tccaggtccc ttctttcggg     6780

atgaggtaac gttcaccgta ggccttaact ccttcgtggt cggctctcag ctcccttgcg     6840

atcctgagcc ggacaccgag gtactggcct ccatgttgac agacccgtcc cacatcaccg     6900

cggaggcggc agccaggcga ttggcaaggg gatctccccc ttcacaggct agctcctcag     6960

cgagccagct ctctgccccg tccttgaagg ctacctgtac cacccataag acagcatatg     7020

attgtgacat ggtggatgcc aaccttttca tgggaggcga tgtgacccgg attgagtctg     7080

actctaaggt gatcgttctc gactccctcg attccatgac tgaggtagag gatgatcgtg     7140

agccttctgt accatcagag tacctgatca agaggagaaa gttcccaccg gcgctgcctc     7200

cttgggcccg tccagactac aatcctgttt tgatcgagac atggaagagg ccgggctatg     7260

aaccacccac tgtcctaggc tgtgccctcc cccccacacc tcaaacgcca gtgcctccac     7320

ctcggaggcg ccgcgccaaa gtcctgaccc aggacaatgt ggaggggatc ctcagggaga     7380

tggctgacaa agtactcagc cctctccaag acaacaatga ctccggtcac tccactggag     7440

cggataccgg aggagacatc gtccagcaac cctctgacga gactgccgct tcagaagcgg     7500

ggtcactgtc ctccatgcct ccccttgagg gagagccggg agaccctgac ctggagtttg     7560

aaccagtggg atccgctccc ccttctgagg gggagtgtga ggtcattgat tcggactcta     7620

agtcgtggtc cacagtctct gatcaagagg attctgttat ctgctgctct atgtcatact     7680

cctggacggg ggccctcata acaccatgtg ggcccgaaga ggagaagtta ccgatcaacc     7740

ctctgagtaa ttcgctcatg cggttccata ataaggtgta ctccacaacc tcgaggagtg     7800

cctctctgag ggcaaagaag gtgacttttg acagggtgca ggtgctggac gcacactatg     7860

actcagtctt gcaggacgtt aagcgggccg cctctaaggt tagtgcgagg ctcctcacgg     7920

tagaggaagc ctgcgcgctg accccgcccc actccgccaa atcgcgatac ggatttgggg     7980

caaaagaggt gcgcagctta tccaggaggg ccgttaacca catccggtcc gtgtgggagg     8040

acctcctgga agaccaacat accccaattg acacaactat catggctaaa aatgaggtgt     8100

tctgcattga tccaactaaa ggtgggaaaa agccagctcg cctcatcgta taccccgacc     8160

ttggggtcag ggtgtgcgaa aagatggccc tctatgacat cgcacaaaag cttcccaaag     8220

cgataatggg gccatcctat gggttccaat actctcccgc agaacgggtc gatttcctcc     8280

tcaaagcttg gggaagtaag aaggacccaa tggggttctc gtatgacacc cgctgctttg     8340

actcaaccgt cacggagagg gacataagaa cagaagaatc catatatcag gcttgttctc     8400

tgcctcaaga agccagaact gtcatacact cgctcactga gagactttac gtaggagggc     8460

ccatgacaaa cagcaaaggg caatcctgcg gctacaggcg ttgccgcgca agcggtgttt     8520

tcaccaccag catggggaat accatgacat gttacatcaa agcccttgca gcgtgtaagg     8580

ctgcagggat cgtggaccct gttatgttgg tgtgtggaga cgacctggtc gtcatctcag     8640

agagccaagg taacgaggag gacgagcgaa acctgagagc tttcacggag gctatgacca     8700

ggtattccgc ccctcccggt gaccttccca gaccggaata tgacttggag cttataacat     8760

cctgctcctc aaacgtatcg gtagcgctgg actctcgggg tcgccgccgg tacttcctaa     8820

ccagagaccc taccactcca atcacccgag ctgcttggga aacagtaaga cactcccctg     8880

tcaattcttg gctgggcaac atcatccagt acgcccccac aatctgggtc cggatggtca     8940

taatgactca cttcttctcc atactattgg cccaggacac tctgaaccaa aatctcaatt     9000

ttgagatgta cggggcagta tactcggtca gtccattaga cctaccggcc ataattgaaa     9060

ggctacatgg gcttgaagcc ttttcactgc acacatactc tccccgcgaa ctctcacggg     9120

tggcagcaac tctcagaaaa cttggagcgc ctccccttag agcgtggaag agtcgggcgc     9180

gtgccgtgag agcttcactc atcgcccaag gagcgagggc ggccatttgt ggccgctacc     9240

tcttcaactg ggcggtgaaa acaaagctca aactcactcc attgcccgag gcgagccgcc     9300

tggatttatc cgggtggttc accgtgggcg ccggcggggg cggcatttat cacagcgtgt     9360

cgcatgcccg accccgccta ttactccttt gcctactcct acttagcgta ggagtaggca     9420

tctttttact ccccgctcgg tagagcggca aaccctagct acactccata gctagtttcc     9480

gttttttttt ttttgttttt tttttttttt tttttttttt tttttttttt tttcttttcc     9540

tttttttttt ttctctttct tggtggctcc atcttagccc tagtcacggc tagctgtgaa     9600

aggtccgtga gccgcatgac tgcagagagt gccgtaactg gtctctctgc agatcatgt      9659


<210>  48
<211>  9659
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  48
gcccgccccc tgatgggggc gacactccgc catgaatcac tcccctgtga ggaactactg       60

tcttcacgca gaaagcgtct agccatggcg ttagtatgag tgtcgtacag cctccaggcc      120

cccccctccc gggagagcca tagtggtctg cggaaccggt gagtacaccg gaattaccgg      180

aaagactggg tcctttcttg gataaaccca ctctatgtcc ggtcatttgg gcacgccccc      240

gcaagactgc tagccgagta gcgttgggtt gcgaaaggcc ttgtggtact gcctgatagg      300

gtgcttgcga gtgccccggg aggtctcgta gaccgtgcat catgagcaca aatcctaaac      360

ctcaaagaaa aaccaaaaga aacacaaacc gccgcccaca ggacgttaag ttcccgggtg      420

gcggtcagat cgttggcgga gtttacttgc tgccgcgcag gggccccagg ttgggtgtgc      480

gcgcgacaag gaagacttct gagcgatccc agccgcgtgg acgacgccag cccatcccga      540

aagatcggcg ctccaccggc aagtcctggg gaaagccagg atatccttgg cccctgtacg      600

gaaacgaggg ttgcggctgg gcgggttggc tcctgtcccc ccgcgggtct cgtcctactt      660

ggggccccac cgacccccgg catagatcac gcaatttggg cagagtcatc gataccatta      720

cgtgtggttt tgccgacctc atggggtaca tccctgtcgt tggcgccccg gttggaggcg      780

tcgccagagc tctggcacac ggtgttaggg tcctggagga cgggataaat tacgcaacag      840

ggaatttacc cggttgctct ttttctatct ttttgcttgc tcttctgtca tgcgtcacag      900

tgccagtgtc tgcagtggaa gtcaggaaca ttagttctag ctactacgcc actaatgatt      960

gctcaaacaa cagcatcacc tggcagctca ctgacgcagt tctccatctt cctggatgcg     1020

tcccatgtga gaatgataat ggcaccttgc attgctggat acaagtaaca cccaacgtgg     1080

ctgtgaaaca ccgcggtgcg ctcactcgta gcctgcgaac acacgtcgac atgatcgtaa     1140

tggcagctac ggcctgctcg gccttgtatg tgggagatgt gtgcggggcc gtgatgattc     1200

tatcgcaggc tttcatggta tcaccacaac gccacaactt cacccaagag tgcaactgtt     1260

ccatctacca aggtcacatc accggccatc gcatggcatg ggacatgatg ctgaactggt     1320

ctccaactct tgccatgatc ctcgcctacg ccgctcgtgt tcccgagatg gtcctcgaaa     1380

ttattttcgg cggccattgg ggtgtggtgt ttggcttggc ctacttctcc atgcaaggag     1440

cgtgggccaa agtcattgcc atcctccttc ttgttgcggg agtggatgca accacctatt     1500

ccagcggcca ggaagcgggt cgtaccgtct tggggttcac taacctcttt acttctggtg     1560

ccaagcagaa cctctattta atcaacacca atggcagctg gcacataaac cggactgccc     1620

tcaattgcaa tgacagctta cagacgggtt tcatggcttc cctgttttac acccacaggt     1680

tcaacagctc tggctgcccc gagcgcttgt cttcctgccg cgggctggac gattttcgca     1740

tcggctgggg aaccttggaa tacgaaaccc acgtcaccaa cgatgaggac atgaggccgt     1800

actgctggca ttaccctccg aggccttgcg gcatcgtccc ggctagaacg gtttgcggac     1860

cggtctattg tttcacccct agccctgttg tcgtgggcac cactgacaag cagggcgtac     1920

ccacctacac ctggggggaa aacgagaccg atgtcttcct gctgaatagc acaagacccc     1980

cgcgaggagc ttggttcggc tgcacttgga tgaacgggac tgggttcact aagacatgcg     2040

gtgcaccacc ttgccgcatt aggaaagact acaacagcac tatcgattta ttgtgcccca     2100

cagactgttt taggaagcac cccgatgcta cctatcttaa gtgtggagca gggccttggt     2160

taactcccag gtgcctggta gactaccctt atagactgtg gcattatccg tgcactgtaa     2220

acttcaccat ctttaaggcg cggatgtatg taggaggggt ggagcatcga ttctccgcag     2280

catgcaactt cacgcgcgga gatcgctgca gactggaaga tagggatagg ggtcagcaga     2340

gtccactgct gcattccact actgagtggg cggtgctccc atgctccttc tctgacctac     2400

cagcactatc cactggccta ttgcacctcc accaaaacat cgtggacgtg cagtaccttt     2460

acggactttc tccggctctg acaagataca tcgtgaagtg ggagtgggtg atcctccttt     2520

tcttgttgtt ggcagacgcc aggatctgtg catgcctttg gatgctcatc atactgggcc     2580

aagccgaagc ggcgcttgag aagctcatca tcttgcactc cgctagtgct gctagtgcca     2640

atggtccgct gtggtttttc atcttcttta cagcggcctg gtacttaaag ggcagggtgg     2700

tccccgtggc cacgtactct gttctcggct tatggtcctt cctcctccta gtcctggcct     2760

taccacagca ggcttatgcc ttggacgctg ctgaacaagg ggaactgggg ctggccatat     2820

tagtaattat atccatcttt actcttaccc cagcatacaa gatcctcctg agccgttcag     2880

tgtggtggct gtcctacatg ctggtcttgg ccgaggccca gattcagcaa cgggttcccc     2940

ccctggaggt ccgagggggg cgtgacggaa tcatctgggt ggctgtcatt ctacacccac     3000

gccttgtgtt tgaggtcacg aaatggttgt tagcaatcct ggggcctgcc tacctcctta     3060

aagcgtctct gctacggata ccgtactttg tgagggccca cgctttgcta cgagtgtgta     3120

ccctggtgaa acacctcgcg ggggctaggt acatccagat gctgttgatc accataggca     3180

gatggaccgg cacttacatc tacgaccacc tctccccttt atcaacttgg gcggcccagg     3240

gtttgcggga cctggcaatc gccgtggagc ctgtggtgtt cagcccaatg gagaagaagg     3300

tcattgtgtg gggggctgag acagtggcgt gtggagacat cctgcatggc ctcccggtct     3360

ccgcgaggct aggtagggag gttctgctcg gccctgccga cggctacacc tccaaggggt     3420

ggaagctcct agctcccatt actgcttaca ctcagcaaac tcgtggtctc ctgggtgcta     3480

tcgtggtcag cctaacgggc cgcgacaaaa atgagcaggc tgggcaggtc caggttctgt     3540

cctccgtcac acaaactttc ttggggacat ccatttcggg cgtcctctgg acagtatatc     3600

acggggctgg taataagacc ttggccggcc ccaagggacc agtcactcag atgtacacca     3660

gcgcagaagg ggacctcgtg ggatggccta gtccccccgg gactaagtca ttggacccct     3720

gtacctgcgg ggccgtagac ctctacctgg tcacccgaaa cgctgatgtc attccggtcc     3780

ggaggaaaga tgaccgacgg ggtgcattac tctcgccaag gcccctctca accctcaaag     3840

gatcatccgg agggcccgtg ctctgctcaa ggggacacgc cgtgggcttg ttcagagcgg     3900

ccgtgtgtgc caggggtgta gccaaatcta ttgacttcat ccccgtcgaa tcactcgatg     3960

tcgccacacg gacgcccagt ttctctgaca acagtacgcc gccagctgtg ccccagtctt     4020

accaggtggg ttacttgcac gcaccaacag gcagcggaaa gagcaccaag gtccctgccg     4080

cgtatgccag tcaggggtat aaagtactcg tactaaatcc ctctgtcgcg gccacacttg     4140

gttttggggc ctacatgtcc aaagcccacg ggatcaaccc taatatcaga actggagtgc     4200

ggaccgttac caccggggac tctatcactt actccactta tggcaagttt atcgcagatg     4260

gaggctgtgc agccggtgcc tatgacatca tcatatgcga cgaatgccat tcagtggacg     4320

ctactaccat ccttggcatt ggaacagtcc ttgaccaagc tgagaccgca ggcgtcaggc     4380

tagtggtttt ggccacagcc acgcctcccg gtacggtgac aactccccac agtaacatag     4440

aggaggtggc ccttggtcac gagggcgaga tcccttttta tggcaaagcc attcccctag     4500

ctttcatcaa ggggggcaga cacttgatct tttgccattc aaagaagaag tgcgacgagc     4560

tcgcagcggc cctccggggc atgggtgtca atgccgttgc atactatagg ggtctcgacg     4620

tctccgttat accaactcaa ggagacgtgg tggttgtcgc cactgatgcc ctaatgactg     4680

ggtacaccgg cgactttgac tctgtcatcg actgtaatgt tgcagtctct cagattgttg     4740

acctcagcct agacccaacc ttcaccatca ccactcaaat cgtccctcag gacgctgtct     4800

cccgtagtca acgtagaggg agaactggga gggggcgatt gggcgtttac aggtatgttt     4860

cgtcaggcga aaggccgtct gggatgttcg acagcgtagt gctctgcgag tgctatgatg     4920

ccggggcagc ctggtacgag cttacacctg ctgagactac ggtgagactc cgggcttatt     4980

tcaacacgcc cggtttgccc gtatgtcaag accacctgga gttctgggaa gcggtcttta     5040

caggtctcac acacattgac gcccacttcc tctcccagac gaagcaagga ggagaaaact     5100

ttgcgtatct aacggcctac caggccacag tatgcgccag ggcaaaggcc cctcctcctt     5160

cgtgggacgt gatgtggaag tgtctaacta ggctcaaacc tacactgact ggtcccaccc     5220

ccctcctgta ccgcttgggt gccgtgacca atgaggtcac cttgacgcac cccgtgacga     5280

aatacatcgc cacgtgcatg caagctgacc tcgagatcat gacaagctca tgggtcctgg     5340

cggggggggt gctagccgcc gtggcatctt actgcctggc gactggctgc atttccatca     5400

ttggccgcct acacctgaat gatcgggtgg ttgtggcccc cgacaaggaa atcttatatg     5460

aggcctttga tgagatggaa gaatgcgcct ccaaagccgc cctcattgag gaagggcagc     5520

ggatggcgga gatgctcaaa tctaagatac aaggcctcct acaacaggcc acaaggcaag     5580

ctcaagacat acagccagct atacagtcat catggcccaa gcttgaacaa ttttgggcca     5640

aacacatgtg gaacttcatc agtggtatac agtacctagc aggactctcc accctaccgg     5700

gaaatcctgc agtagcatca atgatggctt ttagcgccgc gctgactagc ccactaccca     5760

ccagcaccac catcctcttg aacatcatgg gaggatggtt ggcctctcag attgcccccc     5820

ctgccggagc cactggcttc gttgtcagtg gtctagtggg ggcggccgtc ggaagcatag     5880

gcctgggtaa gatactggtg gacgttttgg ccgggtacgg cgcaggcatt tcaggggccc     5940

tcgtagcttt taagatcatg agcggcgaga agcccacggt agaagacgtt gtgaatctcc     6000

tgcctgctat tctgtctcct ggtgcgttgg tagtgggagt catctgtgca gcaatcctgc     6060

gccgccacgt cggtcaggga gagggggcgg tccagtggat gaacagactg atcgccttcg     6120

cctccagggg aaaccacgtt gcccctaccc actacgtggt ggagtctgac gcttcacagc     6180

gtgtaacgca ggtgctgagt tcacttacaa ttaccagctt acttaggaga ctacatgcct     6240

ggatcactga agattgccca gtcccatgct cggggtcttg gctccaggac atttgggatt     6300

gggtttgttc catcctcaca gacttcaaaa actggctgtc ttcaaaatta ctccccaaga     6360

tgcccggcat tccctttatc tcttgccaga agggatacaa gggtgtatgg gctggtacgg     6420

gtgtcatgac tactcggtgc ccatgtggag caaacatctc gggccatgtc cgcatgggca     6480

ccatgaaaat aacaggcccg aagacttgct tgaacctgtg gcaggggact ttccccatta     6540

attgttacac agaagggcct tgcgtgccaa aaccccctcc taattacaag accgcaattt     6600

ggagggtggc agcgtcggag tacgttgagg tcacacagca tggctctttc tcgtatgtaa     6660

cagggttaac cagtgacaac cttaaggtcc cttgccaggt accagctcca gaatttttct     6720

cttgggtgga cggggtgcaa atccaccgat tcgcccccgt tccaggtccc ttctttcggg     6780

atgaggtaac gttcaccgta ggccttaact ccttcgtggt cggctctcag ctcccttgcg     6840

atcctgagcc ggacaccgag gtactggcct ccatgttgac agacccgtcc cacatcaccg     6900

cggaggcggc agccaggcga ttggcaaggg gatctccccc ttcacaggct agctcctcag     6960

cgagccagct ctctgccccg tccttgaagg ctacctgtac cacccataag acagcatatg     7020

attgtgacat ggtggatgcc aaccttttca tgggaggcga tgtgacccgg attgagtctg     7080

actctaaggt gatcgttctc gactccctcg attccatgac tgaggtagag gatgatcgtg     7140

agccttctgt accatcagag tacctgatca agaggagaaa gttcccaccg gcgctgcctc     7200

cttgggcccg tccagactac aatcctgttt tgatcgagac atggaagagg ccgggctatg     7260

aaccacccac tgtcctaggc tgtgccctcc cccccacacc tcaaacgcca gtgcctccac     7320

ctcggaggcg ccgcgccaaa gtcctgaccc aggacaatgt ggaggggatc ctcagggaga     7380

tggctgacaa agtactcagc cctctccaag acaacaatga ctccggtcac tccactggag     7440

cggataccgg aggagacatc gtccagcaac cctctgacga gactgccgct tcagaagcgg     7500

ggtcactgtc ctccatgcct ccccttgagg gagagccggg agaccctgac ctggagtttg     7560

aaccagtggg atccgctccc ccttctgagg gggagtgtga ggtcattgat tcggactcta     7620

agtcgtggtc cacagtctct gatcaagagg attctgttat ctgctgctct atgtcatact     7680

cctggacggg ggccctcata acaccatgtg ggcccgaaga ggagaagtta ccgatcaacc     7740

ctctgagtaa ttcgctcatg cggttccata ataaggtgta ctccacaacc tcgaggagtg     7800

cctctctgag ggcaaagaag gtgacttttg acagggtgca ggtgctggac gcacactatg     7860

actcagtctt gcaggacgtt aagcgggccg cctctaaggt tagtgcgagg ctcctcacgg     7920

tagaggaagc ctgcgcgctg accccgcccc actccgccaa atcgcgatac ggatttgggg     7980

caaaagaggt gcgcagctta tccaggaggg ccgttaacca catccggtcc gtgtgggagg     8040

acctcctgga agaccaacat accccaattg acacaactat catggctaaa aatgaggtgt     8100

tctgcattga tccaactaaa ggtgggaaaa agccagctcg cctcatcgta taccccgacc     8160

ttggggtcag ggtgtgcgaa aagatggccc tctatgacat cgcacaaaag cttcccaaag     8220

cgataatggg gccatcctat gggttccaat actctcccgc agaacgggtc gatttcctcc     8280

tcaaagcttg gggaagtaag aaggacccaa tggggttctc gtatgacacc cgctgctttg     8340

actcaaccgt cacggagagg gacataagaa cagaagaatc catatatcag gcttgttctc     8400

tgcctcaaga agccagaact gtcatacact cgctcactga gagactttac gtaggagggc     8460

ccatgacaaa cagcaaaggg caatcctgcg gctacaggcg ttgccgcgca agcggtgttt     8520

tcaccaccag catggggaat accatgacat gttacatcaa agcccttgca gcgtgtaagg     8580

ctgcagggat cgtggaccct gttatgttgg tgtgtggaga cgacctggtc gtcatctcag     8640

agagccaagg taacgaggag gacgagcgaa acctgagagc tttcacggag gctatgacca     8700

ggtattccgc ccctcccggt gaccttccca gaccggaata tgacttggag cttataacat     8760

cctgctcctc aaacgtatcg gtagcgctgg actctcgggg tcgccgccgg tacttcctaa     8820

ccagagaccc taccactcca atcacccgag ctgcttggga aacagtaaga cactcccctg     8880

tcaattcttg gctgggcaac atcatccagt acgcccccac aatctgggtc cggatggtca     8940

taatgactca cttcttctcc atactattgg cccaggacac tctgaaccaa aatctcaatt     9000

ttgagatgta cggggcagta tactcggtca atccattaga cctaccggcc ataattgaaa     9060

ggctacatgg gcttgaagcc ttttcactgc acacatactc tccccgcgaa ctctcacggg     9120

tggcagcaac tctcagaaaa cttggagcgc ctccccttag agcgtggaag agtcgggcgc     9180

gtgccgtgag agcttcactc atcgcccaag gagcgagggc ggccatttgt ggccgctacc     9240

tcttcaactg ggcggtgaaa acaaagctca aactcactcc attgcccgag gcgagccgcc     9300

tggatttatc cgggtggttc accgtgggcg ccggcggggg cggcatttat cacagcgtgt     9360

cgcatgcccg accccgccta ttactccttt gcctactcct acttagcgta ggagtaggca     9420

tctttttact ccccgctcgg tagagcggca aaccctagct acactccata gctagtttcc     9480

gttttttttt ttttgttttt tttttttttt tttttttttt tttttttttt tttcttttcc     9540

tttttttttt ttctctttct tggtggctcc atcttagccc tagtcacggc tagctgtgaa     9600

aggtccgtga gccgcatgac tgcagagagt gccgtaactg gtctctctgc agatcatgt      9659


<210>  49
<211>  9659
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  49
gcccgccccc tgatgggggc gacactccgc catgaatcac tcccctgtga ggaactactg       60

tcttcacgca gaaagcgtct agccatggcg ttagtatgag tgtcgtacag cctccaggcc      120

cccccctccc gggagagcca tagtggtctg cggaaccggt gagtacaccg gaattaccgg      180

aaagactggg tcctttcttg gataaaccca ctctatgtcc ggtcatttgg gcacgccccc      240

gcaagactgc tagccgagta gcgttgggtt gcgaaaggcc ttgtggtact gcctgatagg      300

gtgcttgcga gtgccccggg aggtctcgta gaccgtgcat catgagcaca aatcctaaac      360

ctcaaagaaa aaccaaaaga aacacaaacc gccgcccaca ggacgttaag ttcccgggtg      420

gcggtcagat cgttggcgga gtttacttgc tgccgcgcag gggccccagg ttgggtgtgc      480

gcgcgacaag gaagacttct gagcgatccc agccgcgtgg acgacgccag cccatcccga      540

aagatcggcg ctccaccggc aagtcctggg gaaagccagg atatccttgg cccctgtacg      600

gaaacgaggg ttgcggctgg gcgggttggc tcctgtcccc ccgcgggtct cgtcctactt      660

ggggccccac cgacccccgg catagatcac gcaatttggg cagagtcatc gataccatta      720

cgtgtggttt tgccgacctc atggggtaca tccctgtcgt tggcgccccg gttggaggcg      780

tcgccagagc tctggcacac ggtgttaggg tcctggagga cgggataaat tacgcaacag      840

ggaatttacc cggttgctct ttttctatct ttttgcttgc tcttctgtca tgcgtcacag      900

tgccagtgtc tgcagtggaa gtcaggaaca ttagttctag ctactacgcc actaatgatt      960

gctcaaacaa cagcatcacc tggcagctca ctgacgcagt tctccatctt cctggatgcg     1020

tcccatgtga gaatgataat ggcaccttgc attgctggat acaagtaaca cccaacgtgg     1080

ctgtgaaaca ccgcggtgcg ctcactcgta gcctgcgaac acacgtcgac atgatcgtaa     1140

tggcagctac ggcctgctcg gccttgtatg tgggagatgt gtgcggggcc gtgatgattc     1200

tatcgcaggc tttcatggta tcaccacaac gccacaactt cacccaagag tgcaactgtt     1260

ccatctacca aggtcacatc accggccatc gcatggcatg ggacatgatg ctgaactggt     1320

ctccaactct tgccatgatc ctcgcctacg ccgctcgtgt tcccgagatg gtcctcgaaa     1380

ttattttcgg cggccattgg ggtgtggtgt ttggcttggc ctacttctcc atgcaaggag     1440

cgtgggccaa agtcattgcc atcctccttc ttgttgcggg agtggatgca accacctatt     1500

ccagcggcca ggaagcgggt cgtaccgtct tggggttcac taacctcttt acttctggtg     1560

ccaagcagaa cctctattta atcaacacca atggcagctg gcacataaac cggactgccc     1620

tcaattgcaa tgacagctta cagacgggtt tcatggcttc cctgttttac acccacaggt     1680

tcaacagctc tggctgcccc gagcgcttgt cttcctgccg cgggctggac gattttcgca     1740

tcggctgggg aaccttggaa tacgaaaccc acgtcaccaa cgatgaggac atgaggccgt     1800

actgctggca ttaccctccg aggccttgcg gcatcgtccc ggctagaacg gtttgcggac     1860

cggtctattg tttcacccct agccctgttg tcgtgggcac cactgacaag cagggcgtac     1920

ccacctacac ctggggggaa aacgagaccg atgtcttcct gctgaatagc acaagacccc     1980

cgcgaggagc ttggttcggc tgcacttgga tgaacgggac tgggttcact aagacatgcg     2040

gtgcaccacc ttgccgcatt aggaaagact acaacagcac tatcgattta ttgtgcccca     2100

cagactgttt taggaagcac cccgatgcta cctatcttaa gtgtggagca gggccttggt     2160

taactcccag gtgcctggta gactaccctt atagactgtg gcattatccg tgcactgtaa     2220

acttcaccat ctttaaggcg cggatgtatg taggaggggt ggagcatcga ttctccgcag     2280

catgcaactt cacgcgcgga gatcgctgca gactggaaga tagggatagg ggtcagcaga     2340

gtccactgct gcattccact actgagtggg cggtgctccc atgctccttc tctgacctac     2400

cagcactatc cactggccta ttgcacctcc accaaaacat cgtggacgtg cagtaccttt     2460

acggactttc tccggctctg acaagataca tcgtgaagtg ggagtgggtg atcctccttt     2520

tcttgttgtt ggcagacgcc aggatctgtg catgcctttg gatgctcatc atactgggcc     2580

aagccgaagc ggcgcttgag aagctcatca tcttgcactc cgctagtgct gctagtgcca     2640

atggtccgct gtggtttttc atcttcttta cagcggcctg gtacttaaag ggcagggtgg     2700

tccccgtggc cacgtactct gttctcggct tatggtcctt cctcctccta gtcctggcct     2760

taccacagca ggcttatgcc ttggacgctg ctgaacaagg ggaactgggg ctggccatat     2820

tagtaattat atccatcttt actcttaccc cagcatacaa gatcctcctg agccgttcag     2880

tgtggtggct gtcctacatg ctggtcttgg ccgaggccca gattcagcaa tgggttcccc     2940

ccctggaggt ccgagggggg cgtgacggaa tcatctgggt ggctgtcatt ctacacccac     3000

gccttgtgtt tgaggtcacg aaatggttgt tagcaatcct ggggcctgcc tacctcctta     3060

aagcgtctct gctacggata ccgtactttg tgagggccca cgctttgcta cgagtgtgta     3120

ccctggtgaa acacctcgcg ggggctaggt acatccagat gctgttgatc accataggca     3180

gatggaccgg cacttacatc tacgaccacc tctccccttt atcaacttgg gcggcccagg     3240

gtttgcggga cctggcaatc gccgtggagc ctgtggtgtt cagcccaatg gagaagaagg     3300

tcattgtgtg gggggctgag acagtggcgt gtggagacat cctgcatggc ctcccggtct     3360

ccgcgaggct aggtagggag gttctgctcg gccctgccga cggctacacc tccaaggggt     3420

ggaagctcct agctcccatt actgcttaca ctcagcaaac tcgtggtctc ctgggtgcta     3480

tcgtggtcag cctaacgggc cgcgacaaaa atgagcaggc tgggcaggtc caggttctgt     3540

cctccgtcac acaaactttc ttggggacat ccatttcggg cgtcctctgg acagtatatc     3600

acggggctgg taataagacc ttggccggcc ccaagggacc agtcactcag atgtacacca     3660

gcgcagaagg ggacctcgtg ggatggccta gtccccccgg gactaagtca ttggacccct     3720

gtacctgcgg ggccgtagac ctctacctgg tcacccgaaa cgctgatgtc attccggtcc     3780

ggaggaaaga tgaccgacgg ggtgcattac tctcgccaag gcccctctca accctcaaag     3840

gatcatccgg agggcccgtg ctctgctcaa ggggacacgc cgtgggcttg ttcagagcgg     3900

ccgtgtgtgc caggggtgta gccaaatcta ttgacttcat ccccgtcgaa tcactcgatg     3960

tcgccacacg gacgcccagt ttctctgaca acagtacgcc gccagctgtg ccccagtctt     4020

accaggtggg ttacttgcac gcaccaacag gcagcggaaa gagcaccaag gtccctgccg     4080

cgtatgccag tcaggggtat aaagtactcg tactaaatcc ctctgtcgcg gccacacttg     4140

gttttggggc ctacatgtcc aaagcccacg ggatcaaccc taatatcaga actggagtgc     4200

ggaccgttac caccggggac tctatcactt actccactta tggcaagttt atcgcagatg     4260

gaggctgtgc agccggtgcc tatgacatca tcatatgcga cgaatgccat tcagtggacg     4320

ctactaccat ccttggcatt ggaacagtcc ttgaccaagc tgagaccgca ggcgtcaggc     4380

tagtggtttt ggccacagcc acgcctcccg gtacggtgac aactccccac agtaacatag     4440

aggaggtggc ccttggtcac gagggcgaga tcccttttta tggcaaagcc attcccctag     4500

ctttcatcaa ggggggcaga cacttgatct tttgccattc aaagaagaag tgcgacgagc     4560

tcgcagcggc cctccggggc atgggtgtca atgccgttgc atactatagg ggtctcgacg     4620

tctccgttat accaactcaa ggagacgtgg tggttgtcgc cactgatgcc ctaatgactg     4680

ggtacaccgg cgactttgac tctgtcatcg actgtaatgt tgcagtctct cagattgttg     4740

acctcagcct agacccaacc ttcaccatca ccactcaaat cgtccctcag gacgctgtct     4800

cccgtagtca acgtagaggg agaactggga gggggcgatt gggcgtttac aggtatgttt     4860

cgtcaggcga aaggccgtct gggatgttcg acagcgtagt gctctgcgag tgctatgatg     4920

ccggggcagc ctggtacgag cttacacctg ctgagactac ggtgagactc cgggcttatt     4980

tcaacacgcc cggtttgccc gtatgtcaag accacctgga gttctgggaa gcggtcttta     5040

caggtctcac acacattgac gcccacttcc tctcccagac gaagcaagga ggagaaaact     5100

ttgcgtatct aacggcctac caggccacag tatgcgccag ggcaaaggcc cctcctcctt     5160

cgtgggacgt gatgtggaag tgtctaacta ggctcaaacc tacactgact ggtcccaccc     5220

ccctcctgta ccgcttgggt gccgtgacca atgaggtcac cttgacgcac cccgtgacga     5280

aatacatcgc cacgtgcatg caagctgacc tcgagatcat gacaagctca tgggtcctgg     5340

cggggggggt gctagccgcc gtggcatctt actgcctggc gactggctgc atttccatca     5400

ttggccgcct acacctgaat gatcgggtgg ttgtggcccc cgacaaggaa atcttatatg     5460

aggcctttga tgagatggaa gaatgcgcct ccaaagccgc cctcattgag gaagggcagc     5520

ggatggcgga gatgctcaaa tctaagatac aaggcctcct acaacaggcc acaaggcaag     5580

ctcaagacat acagccagct atacagtcat catggcccaa gcttgaacaa ttttgggcca     5640

aacacatgtg gaacttcatc agtggtatac agtacctagc aggactctcc accctaccgg     5700

gaaatcctgc agtagcatca atgatggctt ttagcgccgc gctgactagc ccactaccca     5760

ccagcaccac catcctcttg aacatcatgg gaggatggtt ggcctctcag attgcccccc     5820

ctgccggagc cactggcttc gttgtcagtg gtctagtggg ggcggccgtc ggaagcatag     5880

gcctgggtaa gatactggtg gacgttttgg ccgggtacgg cgcaggcatt tcaggggccc     5940

tcgtagcttt taagatcatg agcggcgaga agcccacggt agaagacgtt gtgaatctcc     6000

tgcctgctat tctgtctcct ggtgcgttgg tagtgggagt catctgtgca gcaatcctgc     6060

gccgccacgt cggtcaggga gagggggcgg tccagtggat gaacagactg atcgccttcg     6120

cctccagggg aaaccacgtt gcccctaccc actacgtggt ggagtctgac gcttcacagc     6180

gtgtaacgca ggtgctgagt tcacttacaa ttaccagctt acttaggaga ctacatgcct     6240

ggatcactga agattgccca gtcccatgct cggggtcttg gctccaggac atttgggatt     6300

gggtttgttc catcctcaca gacttcaaaa actggctgtc ttcaaaatta ctccccaaga     6360

tgcccggcat tccctttatc tcttgccaga agggatacaa gggtgtatgg gctggtacgg     6420

gtgtcatgac tactcggtgc ccatgtggag caaacatctc gggccatgtc cgcatgggca     6480

ccatgaaaat aacaggcccg aagacttgct tgaacctgtg gcaggggact ttccccatta     6540

attgttacac agaagggcct tgcgtgccaa aaccccctcc taattacaag accgcaattt     6600

ggagggtggc agcgtcggag tacgttgagg tcacacagca tggctctttc tcgtatgtaa     6660

cagggttaac cagtgacaac cttaaggtcc cttgccaggt accagctcca gaatttttct     6720

cttgggtgga cggggtgcaa atccaccgat tcgcccccgt tccaggtccc ttctttcggg     6780

atgaggtaac gttcaccgta ggccttaact ccttcgtggt cggctctcag ctcccttgcg     6840

atcctgagcc ggacaccgag gtactggcct ccatgttgac agacccgtcc cacatcaccg     6900

cggaggcggc agccaggcga ttggcaaggg gatctccccc ttcacaggct agctcctcag     6960

cgagccagct ctctgccccg tccttgaagg ctacctgtac cacccataag acagcatatg     7020

attgtgacat ggtggatgcc aaccttttca tgggaggcga tgtgacccgg attgagtctg     7080

actctaaggt gatcgttctc gactccctcg attccatgac tgaggtagtg gatgatcgtg     7140

agccttctgt accatcagag tacctgatca agaggagaaa gttcccaccg gcgctgcctc     7200

cttgggcccg tccagactac aatcctgttt tgatcgagac atggaagagg ccgggctatg     7260

aaccacccac tgtcctaggc tgtgccctcc cccccacacc tcaaacgcca gtgcctccac     7320

ctcggaggcg ccgcgccaaa gtcctgaccc aggacaatgt ggaggggatc ctcagggaga     7380

tggctgacaa agtactcagc cctctccaag acaacaatga ctccggtcac tccactggag     7440

cggataccgg aggagacatc gtccagcaac cctctgacga gactgccgct tcagaagcgg     7500

ggtcactgtc ctccatgcct ccccttgagg gagagccggg agaccctgac ctggagtttg     7560

aaccagtggg atccgctccc ccttctgagg gggagtgtga ggtcattgat tcggactcta     7620

agtcgtggtc cacagtctct gatcaagagg attctgttat ctgctgctct atgtcatact     7680

cctggacggg ggccctcata acaccatgtg ggcccgaaga ggagaagtta ccgatcaacc     7740

ctctgagtaa ttcgctcatg cggttccata ataaggtgta ctccacaacc tcgaggagtg     7800

cctctctgag ggcaaagaag gtgacttttg acagggtgca ggtgctggac gcacactatg     7860

actcagtctt gcaggacgtt aagcgggccg cctctaaggt tagtgcgagg ctcctcacgg     7920

tagaggaagc ctgcgcgctg accccgcccc actccgccaa atcgcgatac ggatttgggg     7980

caaaagaggt gcgcagctta tccaggaggg ccgttaacca catccggtcc gtgtgggagg     8040

acctcctgga agaccaacat accccaattg acacaactat catggctaaa aatgaggtgt     8100

tctgcattga tccaactaaa ggtgggaaaa agccagctcg cctcatcgta taccccgacc     8160

ttggggtcag ggtgtgcgaa aagatggccc tctatgacat cgcacaaaag cttcccaaag     8220

cgataatggg gccatcctat gggttccaat actctcccgc agaacgggtc gatttcctcc     8280

tcaaagcttg gggaagtaag aaggacccaa tggggttctc gtatgacacc cgctgctttg     8340

actcaaccgt cacggagagg gacataagaa cagaagaatc catatatcag gcttgttctc     8400

tgcctcaaga agccagaact gtcatacact cgctcactga gagactttac gtaggagggc     8460

ccatgacaaa cagcaaaggg caatcctgcg gctacaggcg ttgccgcgca agcggtgttt     8520

tcaccaccag catggggaat accatgacat gttacatcaa agcccttgca gcgtgtaagg     8580

ctgcagggat cgtggaccct gttatgttgg tgtgtggaga cgacctggtc gtcatctcag     8640

agagccaagg taacgaggag gacgagcgaa acctgagagc tttcacggag gctatgacca     8700

ggtattccgc ccctcccggt gaccttccca gaccggaata tgacttggag cttataacat     8760

cctgctcctc aaacgtatcg gtagcgctgg actctcgggg tcgccgccgg tacttcctaa     8820

ccagagaccc taccactcca atcacccgag ctgcttggga aacagtaaga cactcccctg     8880

tcaattcttg gctgggcaac atcatccagt acgcccccac aatctgggtc cggatggtca     8940

taatgactca cttcttctcc atactattgg cccaggacac tctgaaccaa aatctcaatt     9000

ttgagatgta cggggcagta tactcggtca atccattaga cctaccggcc ataattgaaa     9060

ggctacatgg gcttgaagcc ttttcactgc acacatactc tccccgcgaa ctctcacggg     9120

tggcagcaac tctcagaaaa cttggagcgc ctccccttag agcgtggaag agtcgggcgc     9180

gtgccgtgag agcttcactc atcgcccaag gagcgagggc ggccatttgt ggccgctacc     9240

tcttcaactg ggcggtgaaa acaaagctca aactcactcc attgcccgag gcgagccgcc     9300

tggatttatc cgggtggttc accgtgggcg ccggcggggg cggcatttat cacagcgtgt     9360

cgcatgcccg accccgccta ttactccttt gcctactcct acttagcgta ggagtaggca     9420

tctttttact ccccgctcgg tagagcggca aaccctagct acactccata gctagtttcc     9480

gttttttttt ttttgttttt tttttttttt tttttttttt tttttttttt tttcttttcc     9540

tttttttttt ttctctttct tggtggctcc atcttagccc tagtcacggc tagctgtgaa     9600

aggtccgtga gccgcatgac tgcagagagt gccgtaactg gtctctctgc agatcatgt      9659


<210>  50
<211>  9659
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  50
gcccgccccc tgatgggggc gacactccgc catgaatcac tcccctgtga ggaactactg       60

tcttcacgca gaaagcgtct agccatggcg ttagtatgag tgtcgtacag cctccaggcc      120

cccccctccc gggagagcca tagtggtctg cggaaccggt gagtacaccg gaattaccgg      180

aaagactggg tcctttcttg gataaaccca ctctatgtcc ggtcatttgg gcacgccccc      240

gcaagactgc tagccgagta gcgttgggtt gcgaaaggcc ttgtggtact gcctgatagg      300

gtgcttgcga gtgccccggg aggtctcgta gaccgtgcat catgagcaca aatcctaaac      360

ctcaaagaaa aaccaaaaga aacacaaacc gccgcccaca ggacgttaag ttcccgggtg      420

gcggtcagat cgttggcgga gtttacttgc tgccgcgcag gggccccagg ttgggtgtgc      480

gcgcgacaag gaagacttct gagcgatccc agccgcgtgg acgacgccag cccatcccga      540

aagatcggcg ctccaccggc aagtcctggg gaaagccagg atatccttgg cccctgtacg      600

gaaacgaggg ttgcggctgg gcgggttggc tcctgtcccc ccgcgggtct cgtcctactt      660

ggggccccac cgacccccgg catagatcac gcaatttggg cagagtcatc gataccatta      720

cgtgtggttt tgccgacctc atggggtaca tccctgtcgt tggcgccccg gttggaggcg      780

tcgccagagc tctggcacac ggtgttaggg tcctggagga cgggataaat tacgcaacag      840

ggaatttacc cggttgctct ttttctatct ttttgcttgc tcttctgtca tgcgtcacag      900

tgccagtgtc tgcagtggaa gtcaggaaca ttagttctag ctactacgcc actaatgatt      960

gctcaaacaa cagcatcacc tggcagctca ctgacgcagt tctccatctt cctggatgcg     1020

tcccatgtga gaatgataat ggcaccttgc attgctggat acaagtaaca cccaacgtgg     1080

ctgtgaaaca ccgcggtgcg ctcactcgta gcctgcgaac acacgtcgac atgatcgtaa     1140

tggcagctac ggcctgctcg gccttgtatg tgggagatgt gtgcggggcc gtgatgattc     1200

tatcgcaggc tttcatggta tcaccacaac gccacaactt cacccaagag tgcaactgtt     1260

ccatctacca aggtcacatc accggccatc gcatggcatg ggacatgatg ctgaactggt     1320

ctccaactct tgccatgatc ctcgcctacg ccgctcgtgt tcccgagatg gtcctcgaaa     1380

ttattttcgg cggccattgg ggtgtggtgt ttggcttggc ctacttctcc atgcaaggag     1440

cgtgggccaa agtcattgcc atcctccttc ttgttgcggg agtggatgca accacctatt     1500

ccagcggcca ggaagcgggt cgtaccgtct tggggttcac taacctcttt acttctggtg     1560

ccaagcagaa cctctattta atcaacacca atggcagctg gcacataaac cggactgccc     1620

tcaattgcaa tgacagctta cagacgggtt tcatggcttc cctgttttac acccacaggt     1680

tcaacagctc tggctgcccc gagcgcttgt cttcctgccg cgggctggac gattttcgca     1740

tcggctgggg aaccttggaa tacgaaaccc acgtcaccaa cgatgaggac atgaggccgt     1800

actgctggca ttaccctccg aggccttgcg gcatcgtccc ggctagaacg gtttgcggac     1860

cggtctattg tttcacccct agccctgttg tcgtgggcac cactgacaag cagggcgtac     1920

ccacctacac ctggggggaa aacgagaccg atgtcttcct gctgaatagc acaagacccc     1980

cgcgaggagc ttggttcggc tgcacttgga tgaacgggac tgggttcact aagacatgcg     2040

gtgcaccacc ttgccgcatt aggaaagact acaacagcac tatcgattta ttgtgcccca     2100

cagactgttt taggaagcac cccgatgcta cctatcttaa gtgtggagca gggccttggt     2160

taactcccag gtgcctggta gactaccctt atagactgtg gcattatccg tgcactgtaa     2220

acttcaccat ctttaaggcg cggatgtatg taggaggggt ggagcatcga ttctccgcag     2280

catgcaactt cacgcgcgga gatcgctgca gactggaaga tagggatagg ggtcagcaga     2340

gtccactgct gcattccact actgagtggg cggtgctccc atgctccttc tctgacctac     2400

cagcactatc cactggccta ttgcacctcc accaaaacat cgtggacgtg cagtaccttt     2460

acggactttc tccggctctg acaagataca tcgtgaagtg ggagtgggtg atcctccttt     2520

tcttgttgtt ggcagacgcc aggatctgtg catgcctttg gatgctcatc atactgggcc     2580

aagccgaagc ggcgcttgag aagctcatca tcttgcactc cgctagtgct gctagtgcca     2640

atggtccgct gtggtgtttc atcttcttta cagcggcctg gtacttaaag ggcagggtgg     2700

tccccgtggc cacgtactct gttctcggct tatggtcctt cctcctccta gtcctggcct     2760

taccacagca ggcttatgcc ttggacgctg ctgaacaagg ggaactgggg ctggccatat     2820

tagtaattat atccatcttt actcttaccc cagcatacaa gatcctcctg agccgttcag     2880

tgtggtggct gtcctacatg ctggtcttgg ccgaggccca gattcagcaa tgggttcccc     2940

ccctggaggt ccgagggggg cgtgacggaa tcatctgggt ggctgtcatt ctacacccac     3000

gccttgtgtt tgaggtcacg aaatggttgt tagcaatcct ggggcctgcc tacctcctta     3060

aagcgtctct gctacggata ccgtactttg tgagggccca cgctttgcta cgagtgtgta     3120

ccctggtgaa acacctcgcg ggggctaggt acatccagat gctgttgatc accataggca     3180

gatggaccgg cacttacatc tacgaccacc tctccccttt atcaacttgg gcggcccagg     3240

gtttgcggga cctggcaatc gccgtggagc ctgtggtgtt cagcccaatg gagaagaagg     3300

tcattgtgtg gggggctgag acagtggcgt gtggagacat cctgcatggc ctcccggtct     3360

ccgcgaggct aggtagggag gttctgctcg gccctgccga cggctacacc tccaaggggt     3420

ggaagctcct agctcccatt actgcttaca ctcagcaaac tcgtggtctc ctgggtgcta     3480

tcgtggtcag cctaacgggc cgcgacaaaa atgagcaggc tgggcaggtc caggttctgt     3540

cctccgtcac acaaactttc ttggggacat ccatttcggg cgtcctctgg acagtatatc     3600

acggggctgg taataagacc ttggccggcc ccaagggacc agtcactcag atgtacacca     3660

gcgcagaagg ggacctcgtg ggatggccta gtccccccgg gactaagtca ttggacccct     3720

gtacctgcgg ggccgtagac ctctacctgg tcacccgaaa cgctgatgtc attccggtcc     3780

ggaggaaaga tgaccgacgg ggtgcattac tctcgccaag gcccctctca accctcaaag     3840

gatcatccgg agggcccgtg ctctgctcaa ggggacacgc cgtgggcttg ttcagagcgg     3900

ccgtgtgtgc caggggtgta gccaaatcta ttgacttcat ccccgtcgaa tcactcgatg     3960

tcgccacacg gacgcccagt ttctctgaca acagtacgcc gccagctgtg ccccagtctt     4020

accaggtggg ttacttgcac gcaccaacag gcagcggaaa gagcaccaag gtccctgccg     4080

cgtatgccag tcaggggtat aaagtactcg tactaaatcc ctctgtcgcg gccacacttg     4140

gttttggggc ctacatgtcc aaagcccacg ggatcaaccc taatatcaga actggagtgc     4200

ggaccgttac caccggggac tctatcactt actccactta tggcaagttt atcgcagatg     4260

gaggctgtgc agccggtgcc tatgacatca tcatatgcga cgaatgccat tcagtggacg     4320

ctactaccat ccttggcatt ggaacagtcc ttgaccaagc tgagaccgca ggcgtcaggc     4380

tagtggtttt ggccacagcc acgcctcccg gtacggtgac aactccccac agtaacatag     4440

aggaggtggc ccttggtcac gagggcgaga tcccttttta tggcaaagcc attcccctag     4500

ctttcatcaa ggggggcaga cacttgatct tttgccattc aaagaagaag tgcgacgagc     4560

tcgcagcggc cctccggggc atgggtgtca atgccgttgc atactatagg ggtctcgacg     4620

tctccgttat accaactcaa ggagacgtgg tggttgtcgc cactgatgcc ctaatgactg     4680

ggtacaccgg cgactttgac tctgtcatcg actgtaatgt tgcagtctct cagattgttg     4740

acctcagcct agacccaacc ttcaccatca ccactcaaat cgtccctcag gacgctgtct     4800

cccgtagtca acgtagaggg agaactggga gggggcgatt gggcgtttac aggtatgttt     4860

cgtcaggcga aaggccgtct gggatgttcg acagcgtagt gctctgcgag tgctatgatg     4920

ccggggcagc ctggtacgag cttacacctg ctgagactac ggtgagactc cgggcttatt     4980

tcaacacgcc cggtttgccc gtatgtcaag accacctgga gttctgggaa gcggtcttta     5040

caggtctcac acacattgac gcccacttcc tctcccagac gaagcaagga ggagaaaact     5100

ttgcgtatct aacggcctac caggccacag tatgcgccag ggcaaaggcc cctcctcctt     5160

cgtgggacgt gatgtggaag tgtctaacta ggctcaaacc tacactgact ggtcccaccc     5220

ccctcctgta ccgcttgggt gccgtgacca atgaggtcac cttgacgcac cccgtgacga     5280

aatacatcgc cacgtgcatg caagctgacc tcgagatcat gacaagctca tgggtcctgg     5340

cggggggggt gctagccgcc gtggcatctt actgcctggc gactggctgc atttccatca     5400

ttggccgcct acacctgaat gatcgggtgg ttgtggcccc cgacaaggaa atcttatatg     5460

aggcctttga tgagatggaa gaatgcgcct ccaaagccgc cctcattgag gaagggcagc     5520

ggatggcgga gatgctcaaa tctaagatac aaggcctcct acaacaggcc acaaggcaag     5580

ctcaagacat acagccagct atacagtcat catggcccaa gcttgaacaa ttttgggcca     5640

aacacatgtg gaacttcatc agtggtatac agtacctagc aggactctcc accctaccgg     5700

gaaatcctgc agtagcatca atgatggctt ttagcgccgc gctgactagc ccactaccca     5760

ccagcaccac catcctcttg aacatcatgg gaggatggtt ggcctctcag attgcccccc     5820

ctgccggagc cactggcttc gttgtcagtg gtctagtggg ggcggccgtc ggaagcatag     5880

gcctgggtaa gatactggtg gacgttttgg ccgggtacgg cgcaggcatt tcaggggccc     5940

tcgtagcttt taagatcatg agcggcgaga agcccacggt agaagacgtt gtgaatctcc     6000

tgcctgctat tctgtctcct ggtgcgttgg tagtgggagt catctgtgca gcaatcctgc     6060

gccgccacgt cggtcaggga gagggggcgg tccagtggat gaacagactg atcgccttcg     6120

cctccagggg aaaccacgtt gcccctaccc actacgtggt ggagtctgac gcttcacagc     6180

gtgtaacgca ggtgctgagt tcacttacaa ttaccagctt acttaggaga ctacatgcct     6240

ggatcactga agattgccca gtcccatgct cggggtcttg gctccaggac atttgggatt     6300

gggtttgttc catcctcaca gacttcaaaa actggctgtc ttcaaaatta ctccccaaga     6360

tgcccggcat tccctttatc tcttgccaga agggatacaa gggtgtatgg gctggtacgg     6420

gtgtcatgac tactcggtgc ccatgtggag caaacatctc gggccatgtc cgcatgggca     6480

ccatgaaaat aacaggcccg aagacttgct tgaacctgtg gcaggggact ttccccatta     6540

attgttacac agaagggcct tgcgtgccaa aaccccctcc taattacaag accgcaattt     6600

ggagggtggc agcgtcggag tacgttgagg tcacacagca tggctctttc tcgtatgtaa     6660

cagggttaac cagtgacaac cttaaggtcc cttgccaggt accagctcca gaatttttct     6720

cttgggtgga cggggtgcaa atccaccgat tcgcccccgt tccaggtccc ttctttcggg     6780

atgaggtaac gttcaccgta ggccttaact ccttcgtggt cggctctcag ctcccttgcg     6840

atcctgagcc ggacaccgag gtactggcct ccatgttgac agacccgtcc cacatcaccg     6900

cggaggcggc agccaggcga ttggcaaggg gatctccccc ttcacaggct agctcctcag     6960

cgagccagct ctctgccccg tccttgaagg ctacctgtac cacccataag acagcatatg     7020

attgtgacat ggtggatgcc aaccttttca tgggaggcga tgtgacccgg attgagtctg     7080

actctaaggt gatcgttctc gactccctcg attccatgac tgaggtagag gatgatcgtg     7140

agccttctgt accatcagag tacctgatca agaggagaaa gttcccaccg gcgctgcctc     7200

cttgggcccg tccagactac aatcctgttt tgatcgagac atggaagagg ccgggctatg     7260

aaccacccac tgtcctaggc tgtgccctcc cccccacacc tcaaacgcca gtgcctccac     7320

ctcggaggcg ccgcgccaaa gtcctgaccc aggacaatgt ggaggggatc ctcagggaga     7380

tggctgacaa agtactcagc cctctccaag acaacaatga ctccggtcac tccactggag     7440

cggataccgg aggagacatc gtccagcaac cctctgacga gactgccgct tcagaagcgg     7500

ggtcactgtc ctccatgcct ccccttgagg gagagccggg agaccctgac ctggagtttg     7560

aaccagtggg atccgctccc ccttctgagg gggagtgtga ggtcattgat tcggactcta     7620

agtcgtggtc cacagtctct gatcaagagg attctgttat ctgctgctct atgtcatact     7680

cctggacggg ggccctcata acaccatgtg ggcccgaaga ggagaagtta ccgatcaacc     7740

ctctgagtaa ttcgctcatg cggttccata ataaggtgta ctccacaacc tcgaggagtg     7800

cctctctgag ggcaaagaag gtgacttttg acagggtgca ggtgctggac gcacactatg     7860

actcagtctt gcaggacgtt aagcgggccg cctctaaggt tagtgcgagg ctcctcacgg     7920

tagaggaagc ctgcgcgctg accccgcccc actccgccaa atcgcgatac ggatttgggg     7980

caaaagaggt gcgcagctta tccaggaggg ccgttaacca catccggtcc gtgtgggagg     8040

acctcctgga agaccaacat accccaattg acacaactat catggctaaa aatgaggtgt     8100

tctgcattga tccaactaaa ggtgggaaaa agccagctcg cctcatcgta taccccgacc     8160

ttggggtcag ggtgtgcgaa aagatggccc tctatgacat cgcacaaaag cttcccaaag     8220

cgataatggg gccatcctat gggttccaat actctcccgc agaacgggtc gatttcctcc     8280

tcaaagcttg gggaagtaag aaggacccaa tggggttctc gtatgacacc cgctgctttg     8340

actcaaccgt cacggagagg gacataagaa cagaagaatc catatatcag gcttgttctc     8400

tgcctcaaga agccagaact gtcatacact cgctcactga gagactttac gtaggagggc     8460

ccatgacaaa cagcaaaggg caatcctgcg gctacaggcg ttgccgcgca agcggtgttt     8520

tcaccaccag catggggaat accatgacat gttacatcaa agcccttgca gcgtgtaagg     8580

ctgcagggat cgtggaccct gttatgttgg tgtgtggaga cgacctggtc gtcatctcag     8640

agagccaagg taacgaggag gacgagcgaa acctgagagc tttcacggag gctatgacca     8700

ggtattccgc ccctcccggt gaccttccca gaccggaata tgacttggag cttataacat     8760

cctgctcctc aaacgtatcg gtagcgctgg actctcgggg tcgccgccgg tacttcctaa     8820

ccagagaccc taccactcca atcacccgag ctgcttggga aacagtaaga cactcccctg     8880

tcaattcttg gctgggcaac atcatccagt acgcccccac aatctgggtc cggatggtca     8940

taatgactca cttcttctcc atactattgg cccaggacac tctgaaccaa aatctcaatt     9000

ttgagatgta cggggcagta tactcggtca gtccattaga cctaccggcc ataattgaaa     9060

ggctacatgg gcttgaagcc ttttcactgc acacatactc tccccgcgaa ctctcacggg     9120

tggcagcaac tctcagaaaa cttggagcgc ctccccttag agcgtggaag agtcgggcgc     9180

gtgccgtgag agcttcactc atcgcccaag gagcgagggc ggccatttgt ggccgctacc     9240

tcttcaactg ggcggtgaaa acaaagctca aactcactcc attgcccgag gcgagccgcc     9300

tggatttatc cgggtggttc accgtgggcg ccggcggggg cggcatttat cacagcgtgt     9360

cgcatgcccg accccgccta ttactccttt gcctactcct acttagcgta ggagtaggca     9420

tctttttact ccccgctcgg tagagcggca aaccctagct acactccata gctagtttcc     9480

gttttttttt ttttgttttt tttttttttt tttttttttt tttttttttt tttcttttcc     9540

tttttttttt ttctctttct tggtggctcc atcttagccc tagtcacggc tagctgtgaa     9600

aggtccgtga gccgcatgac tgcagagagt gccgtaactg gtctctctgc agatcatgt      9659


<210>  51
<211>  9659
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  51
gcccgccccc tgatgggggc gacactccgc catgaatcac tcccctgtga ggaactactg       60

tcttcacgca gaaagcgtct agccatggcg ttagtatgag tgtcgtacag cctccaggcc      120

cccccctccc gggagagcca tagtggtctg cggaaccggt gagtacaccg gaattaccgg      180

aaagactggg tcctttcttg gataaaccca ctctatgtcc ggtcatttgg gcacgccccc      240

gcaagactgc tagccgagta gcgttgggtt gcgaaaggcc ttgtggtact gcctgatagg      300

gtgcttgcga gtgccccggg aggtctcgta gaccgtgcat catgagcaca aatcctaaac      360

ctcaaagaaa aaccaaaaga aacacaaacc gccgcccaca ggacgttaag ttcccgggtg      420

gcggtcagat cgttggcgga gtttacttgc tgccgcgcag gggccccagg ttgggtgtgc      480

gcgcgacaag gaagacttct gagcgatccc agccgcgtgg acgacgccag cccatcccga      540

aagatcggcg ctccaccggc aagtcctggg gaaagccagg atatccttgg cccctgtacg      600

gaaacgaggg ttgcggctgg gcgggttggc tcctgtcccc ccgcgggtct cgtcctactt      660

ggggccccac cgacccccgg catagatcac gcaatttggg cagagtcatc gataccatta      720

cgtgtggttt tgccgacctc atggggtaca tccctgtcgt tggcgccccg gttggaggcg      780

tcgccagagc tctggcacac ggtgttaggg tcctggagga cgggataaat tacgcaacag      840

ggaatttacc cggttgctct ttttctatct ttttgcttgc tcttctgtca tgcgtcacag      900

tgccagtgtc tgcagtggaa gtcaggaaca ttagttctag ctactacgcc actaatgatt      960

gctcaaacaa cagcatcacc tggcagctca ctgacgcagt tctccatctt cctggatgcg     1020

tcccatgtga gaatgataat ggcaccttgc attgctggat acaagtaaca cccaacgtgg     1080

ctgtgaaaca ccgcggtgcg ctcactcgta gcctgcgaac acacgtcgac atgatcgtaa     1140

tggcagctac ggcctgctcg gccttgtatg tgggagatgt gtgcggggcc gtgatgattc     1200

tatcgcaggc tttcatggta tcaccacaac gccacaactt cacccaagag tgcaactgtt     1260

ccatctacca aggtcacatc accggccatc gcatggcatg ggacatgatg ctgaactggt     1320

ctccaactct tgccatgatc ctcgcctacg ccgctcgtgt tcccgagatg gtcctcgaaa     1380

ttattttcgg cggccattgg ggtgtggtgt ttggcttggc ctacttctcc atgcaaggag     1440

cgtgggccaa agtcattgcc atcctccttc ttgttgcggg agtggatgca accacctatt     1500

ccagcggcca ggaagcgggt cgtaccgtct tggggttcac taacctcttt acttctggtg     1560

ccaagcagaa cctctattta atcaacacca atggcagctg gcacataaac cggactgccc     1620

tcaattgcaa tgacagctta cagacgggtt tcatggcttc cctgttttac acccacaggt     1680

tcaacagctc tggctgcccc gagcgcttgt cttcctgccg cgggctggac gattttcgca     1740

tcggctgggg aaccttggaa tacgaaaccc acgtcaccaa cgatgaggac atgaggccgt     1800

actgctggca ttaccctccg aggccttgcg gcatcgtccc ggctagaacg gtttgcggac     1860

cggtctattg tttcacccct agccctgttg tcgtgggcac cactgacaag cagggcgtac     1920

ccacctacac ctggggggaa aacgagaccg atgtcttcct gctgaatagc acaagacccc     1980

cgcgaggagc ttggttcggc tgcacttgga tgaacgggac tgggttcact aagacatgcg     2040

gtgcaccacc ttgccgcatt aggaaagact acaacagcac tatcgattta ttgtgcccca     2100

cagactgttt taggaagcac cccgatgcta cctatcttaa gtgtggagca gggccttggt     2160

taactcccag gtgcctggta gactaccctt atagactgtg gcattatccg tgcactgtaa     2220

acttcaccat ctttaaggcg cggatgtatg taggaggggt ggagcatcga ttctccgcag     2280

catgcaactt cacgcgcgga gatcgctgca gactggaaga tagggatagg ggtcagcaga     2340

gtccactgct gcattccact actgagtggg cggtgctccc atgctccttc tctgacctac     2400

cagcactatc cactggccta ttgcacctcc accaaaacat cgtggacgtg cagtaccttt     2460

acggactttc tccggctctg acaagataca tcgtgaagtg ggagtgggtg atcctccttt     2520

tcttgttgtt ggcagacgcc aggatctgtg catgcctttg gatgctcatc atactgggcc     2580

aagccgaagc ggcgcttgag aagctcatca tcttgcactc cgctagtgct gctagtgcca     2640

atggtccgct gtggtgtttc atcttcttta cagcggcctg gtacttaaag ggcagggtgg     2700

tccccgtggc cacgtactct gttctcggct tatggtcctt cctcctccta gtcctggcct     2760

taccacagca ggcttatgcc ttggacgctg ctgaacaagg ggaactgggg ctggccatat     2820

tagtaattat atccatcttt actcttaccc cagcatacaa gatcctcctg agccgttcag     2880

tgtggtggct gtcctacatg ctggtcttgg ccgaggccca gattcagcaa tgggttcccc     2940

ccctggaggt ccgagggggg cgtgacggaa tcatctgggt ggctgtcatt ctacacccac     3000

gccttgtgtt tgaggtcacg aaatggttgt tagcaatcct ggggcctgcc tacctcctta     3060

aagcgtctct gctacggata ccgtactttg tgagggccca cgctttgcta cgagtgtgta     3120

ccctggtgaa acacctcgcg ggggctaggt acatccagat gctgttgatc accataggca     3180

gatggaccgg cacttacatc tacgaccacc tctccccttt atcaacttgg gcggcccagg     3240

gtttgcggga cctggcaatc gccgtggagc ctgtggtgtt cagcccaatg gagaagaagg     3300

tcattgtgtg gggggctgag acagtggcgt gtggagacat cctgcatggc ctcccggtct     3360

ccgcgaggct aggtagggag gttctgctcg gccctgccga cggctacacc tccaaggggt     3420

ggaagctcct agctcccatt actgcttaca ctcagcaaac tcgtggtctc ctgggtgcta     3480

tcgtggtcag cctaacgggc cgcgacaaaa atgagcaggc tgggcaggtc caggttctgt     3540

cctccgtcac acaaactttc ttggggacat ccatttcggg cgtcctctgg acagtatatc     3600

acggggctgg taataagacc ttggccggcc ccaagggacc agtcactcag atgtacacca     3660

gcgcagaagg ggacctcgtg ggatggccta gtccccccgg gactaagtca ttggacccct     3720

gtacctgcgg ggccgtagac ctctacctgg tcacccgaaa cgctgatgtc attccggtcc     3780

ggaggaaaga tgaccgacgg ggtgcattac tctcgccaag gcccctctca accctcaaag     3840

gatcatccgg agggcccgtg ctctgctcaa ggggacacgc cgtgggcttg ttcagagcgg     3900

ccgtgtgtgc caggggtgta gccaaatcta ttgacttcat ccccgtcgaa tcactcgatg     3960

tcaccacacg gacgcccagt ttctctgaca acagtacgcc gccagctgtg ccccagtctt     4020

accaggtggg ttacttgcac gcaccaacag gcagcggaaa gagcaccaag gtccctgccg     4080

cgtatgccag tcaggggtat aaagtactcg tactaaatcc ctctgtcgcg gccacacttg     4140

gttttggggc ctacatgtcc aaagcccacg ggatcaaccc taatatcaga actggagtgc     4200

ggaccgttac caccggggac tctatcactt actccactta tggcaagttt atcgcagatg     4260

gaggctgtgc agccggtgcc tatgacatca tcatatgcga cgaatgccat tcagtggacg     4320

ctactaccat ccttggcatt ggaacagtcc ttgaccaagc tgagaccgca ggcgtcaggc     4380

tagtggtttt ggccacagcc acgcctcccg gtacggtgac aactccccac agtaacatag     4440

aggaggtggc ccttggtcac gagggcgaga tcccttttta tggcaaagcc attcccctag     4500

ctttcatcaa ggggggcaga cacttgatct tttgccattc aaagaagaag tgcgacgagc     4560

tcgcagcggc cctccggggc atgggtgtca atgccgttgc atactatagg ggtctcgacg     4620

tctccgttat accaactcaa ggagacgtgg tggttgtcgc cactgatgcc ctaatgactg     4680

ggtacaccgg cgactttgac tctgtcatcg actgtaatgt tgcagtctct cagattgttg     4740

acctcagcct agacccaacc ttcaccatca ccactcaaat cgtccctcag gacgctgtct     4800

cccgtagtca acgtagaggg agaactggga gggggcgatt gggcgtttac aggtatgttt     4860

cgtcaggcga aaggccgtct gggatgttcg acagcgtagt gctctgcgag tgctatgatg     4920

ccggggcagc ctggtacgag cttacacctg ctgagactac ggtgagactc cgggcttatt     4980

tcaacacgcc cggtttgccc gtatgtcaag accacctgga gttctgggaa gcggtcttta     5040

caggtctcac acacattgac gcccacttcc tctcccagac gaagcaagga ggagaaaact     5100

ttgcgtatct aacggcctac caggccacag tatgcgccag ggcaaaggcc cctcctcctt     5160

cgtgggacgt gatgtggaag tgtctaacta ggctcaaacc tacactgact ggtcccaccc     5220

ccctcctgta ccgcttgggt gccgtgacca atgaggtcac cttgacgcac cccgtgacga     5280

aatacatcgc cacgtgcatg caagctgacc tcgagatcat gacaagctca tgggtcctgg     5340

cggggggggt gctagccgcc gtggcatctt actgcctggc gactggctgc atttccatca     5400

ttggccgcct acacctgaat gatcgggtgg ttgtggcccc cgacaaggaa atcttatatg     5460

aggcctttga tgagatggaa gaatgcgcct ccaaagccgc cctcattgag gaagggcagc     5520

ggatggcgga gatgctcaaa tctaagatac aaggcctcct acaacaggcc acaaggcaag     5580

ctcaagacat acagccagct atacagtcat catggcccaa gcttgaacaa ttttgggcca     5640

aacacatgtg gaacttcatc agtggtatac agtacctagc aggactctcc accctaccgg     5700

gaaatcctgc agtagcatca atgatggctt ttagcgccgc gctgactagc ccactaccca     5760

ccagcaccac catcctcttg aacatcatgg gaggatggtt ggcctctcag attgcccccc     5820

ctgccggagc cactggcttc gttgtcagtg gtctagtggg ggcggccgtc ggaagcatag     5880

gcctgggtaa gatactggtg gacgttttgg ccgggtacgg cgcaggcatt tcaggggccc     5940

tcgtagcttt taagatcatg agcggcgaga agcccacggt agaagacgtt gtgaatctcc     6000

tgcctgctat tctgtctcct ggtgcgttgg tagtgggagt catctgtgca gcaatcctgc     6060

gccgccacgt cggtcaggga gagggggcgg tccagtggat gaacagactg atcgccttcg     6120

cctccagggg aaaccacgtt gcccctaccc actacgtggt ggagtctgac gcttcacagc     6180

gtgtaacgca ggtgctgagt tcacttacaa ttaccagctt acttaggaga ctacatgcct     6240

ggatcactga agattgccca gtcccatgct cggggtcttg gctccaggac atttgggatt     6300

gggtttgttc catcctcaca gacttcaaaa actggctgtc ttcaaaatta ctccccaaga     6360

tgcccggcat tccctttatc tcttgccaga agggatacaa gggtgtatgg gctggtacgg     6420

gtgtcatgac tactcggtgc ccatgtggag caaacatctc gggccatgtc cgcatgggca     6480

ccatgaaaat aacaggcccg aagacttgct tgaacctgtg gcaggggact ttccccatta     6540

attgttacac agaagggcct tgcgtgccaa aaccccctcc taattacaag accgcaattt     6600

ggagggtggc agcgtcggag tacgttgagg tcacacagca tggctctttc tcgtatgtaa     6660

cagggttaac cagtgacaac cttaaggtcc cttgccaggt accagctcca gaatttttct     6720

cttgggtgga cggggtgcaa atccaccgat tcgcccccgt tccaggtccc ttctttcggg     6780

atgaggtaac gttcaccgta ggccttaact ccttcgtggt cggctctcag ctcccttgcg     6840

atcctgagcc ggacaccgag gtactggcct ccatgttgac agacccgtcc cacatcaccg     6900

cggaggcggc agccaggcga ttggcaaggg gatctccccc ttcacaggct agctcctcag     6960

cgagccagct ctctgccccg tccttgaagg ctacctgtac cacccataag acagcatatg     7020

attgtgacat ggtggatgcc aaccttttca tgggaggcga tgtgacccgg attgagtctg     7080

actctaaggt gatcgttctc gactccctcg attccatgac tgaggtagag gatgatcgtg     7140

agccttctgt accatcagag tacctgatca agaggagaaa gttcccaccg gcgctgcctc     7200

cttgggcccg tccagactac aatcctgttt tgatcgagac atggaagagg ccgggctatg     7260

aaccacccac tgtcctaggc tgtgccctcc cccccacacc tcaaacgcca gtgcctccac     7320

ctcggaggcg ccgcgccaaa gtcctgaccc aggacaatgt ggaggggatc ctcagggaga     7380

tggctgacaa agtactcagc cctctccaag acaacaatga ctccggtcac tccactggag     7440

cggataccgg aggagacatc gtccagcaac cctctgacga gactgccgct tcagaagcgg     7500

ggtcactgtc ctccatgcct ccccttgagg gagagccggg agaccctgac ctggagtttg     7560

aaccagtggg atccgctccc ccttctgagg gggagtgtga ggtcattgat tcggactcta     7620

agtcgtggtc cacagtctct gatcaagagg attctgttat ctgctgctct atgtcatact     7680

cctggacggg ggccctcata acaccatgtg ggcccgaaga ggagaagtta ccgatcaacc     7740

ctctgagtaa ttcgctcatg cggttccata ataaggtgta ctccacaacc tcgaggagtg     7800

cctctctgag ggcaaagaag gtgacttttg acagggtgca ggtgctggac gcacactatg     7860

actcagtctt gcaggacgtt aagcgggccg cctctaaggt tagtgcgagg ctcctcacgg     7920

tagaggaagc ctgcgcgctg accccgcccc actccgccaa atcgcgatac ggatttgggg     7980

caaaagaggt gcgcagctta tccaggaggg ccgttaacca catccggtcc gtgtgggagg     8040

acctcctgga agaccaacat accccaattg acacaactat catggctaaa aatgaggtgt     8100

tctgcattga tccaactaaa ggtgggaaaa agccagctcg cctcatcgta taccccgacc     8160

ttggggtcag ggtgtgcgaa aagatggccc tctatgacat cgcacaaaag cttcccaaag     8220

cgataatggg gccatcctat gggttccaat actctcccgc agaacgggtc gatttcctcc     8280

tcaaagcttg gggaagtaag aaggacccaa tggggttctc gtatgacacc cgctgctttg     8340

actcaaccgt cacggagagg gacataagaa cagaagaatc catatatcag gcttgttctc     8400

tgcctcaaga agccagaact gtcatacact cgctcactga gagactttac gtaggagggc     8460

ccatgacaaa cagcaaaggg caatcctgcg gctacaggcg ttgccgcgca agcggtgttt     8520

tcaccaccag catggggaat accatgacat gttacatcaa agcccttgca gcgtgtaagg     8580

ctgcagggat cgtggaccct gttatgttgg tgtgtggaga cgacctggtc gtcatctcag     8640

agagccaagg taacgaggag gacgagcgaa acctgagagc tttcacggag gctatgacca     8700

ggtattccgc ccctcccggt gaccttccca gaccggaata tgacttggag cttataacat     8760

cctgctcctc aaacgtatcg gtagcgctgg actctcgggg tcgccgccgg tacttcctaa     8820

ccagagaccc taccactcca atcacccgag ctgcttggga aacagtaaga cactcccctg     8880

tcaattcttg gctgggcaac atcatccagt acgcccccac aatctgggtc cggatggtca     8940

taatgactca cttcttctcc atactattgg cccaggacac tctgaaccaa aatctcaatt     9000

ttgagatgta cggggcagta tactcggtca atccattaga cctaccggcc ataattgaaa     9060

ggctacatgg gcttgaagcc ttttcactgc acacatactc tccccgcgaa ctctcacggg     9120

tggcagcaac tctcagaaaa cttggagcgc ctccccttag agcgtggaag agtcgggcgc     9180

gtgccgtgag agcttcactc atcgcccaag gagcgagggc ggccatttgt ggccgctacc     9240

tcttcaactg ggcggtgaaa acaaagctca aactcactcc attgcccgag gcgagccgcc     9300

tggatttatc cgggtggttc accgtgggcg ccggcggggg cggcatttat cacagcgtgt     9360

cgcatgcccg accccgccta ttactccttt gcctactcct acttagcgta ggagtaggca     9420

tctttttact ccccgctcgg tagagcggca aaccctagct acactccata gctagtttcc     9480

gttttttttt ttttgttttt tttttttttt tttttttttt tttttttttt tttcttttcc     9540

tttttttttt ttctctttct tggtggctcc atcttagccc tagtcacggc tagctgtgaa     9600

aggtccgtga gccgcatgac tgcagagagt gccgtaactg gtctctctgc agatcatgt      9659


<210>  52
<211>  9659
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  52
gcccgccccc tgatgggggc gacactccgc catgaatcac tcccctgtga ggaactactg       60

tcttcacgca gaaagcgtct agccatggcg ttagtatgag tgtcgtacag cctccaggcc      120

cccccctccc gggagagcca tagtggtctg cggaaccggt gagtacaccg gaattaccgg      180

aaagactggg tcctttcttg gataaaccca ctctatgtcc ggtcatttgg gcacgccccc      240

gcaagactgc tagccgagta gcgttgggtt gcgaaaggcc ttgtggtact gcctgatagg      300

gtgcttgcga gtgccccggg aggtctcgta gaccgtgcat catgagcaca aatcctaaac      360

ctcaaagaaa aaccaaaaga aacacaaacc gccgcccaca ggacgttaag ttcccgggtg      420

gcggtcagat cgttggcgga gtttacttgc tgccgcgcag gggccccagg ttgggtgtgc      480

gcgcgacaag gaagacttct gagcgatccc agccgcgtgg acgacgccag cccatcccga      540

aagatcggcg ctccaccggc aagtcctggg gaaagccagg atatccttgg cccctgtacg      600

gaaacgaggg ttgcggctgg gcgggttggc tcctgtcccc ccgcgggtct cgtcctactt      660

ggggccccac cgacccccgg catagatcac gcaatttggg cagagtcatc gataccatta      720

cgtgtggttt tgccgacctc atggggtaca tccctgtcgt tggcgccccg gttggaggcg      780

tcgccagagc tctggcacac ggtgttaggg tcctggagga cgggataaat tacgcaacag      840

ggaatttacc cggttgctct ttttctatct ttttgcttgc tcttctgtca tgcgtcacag      900

tgccagtgtc tgcagtggaa gtcaggaaca ttagttctag ctactacgcc actaatgatt      960

gctcaaacaa cagcatcacc tggcagctca ctgacgcagt tctccatctt cctggatgcg     1020

tcccatgtga gaatgataat ggcaccttgc attgctggat acaagtaaca cccaacgtgg     1080

ctgtgaaaca ccgcggtgcg ctcactcgta gcctgcgaac acacgtcgac atgatcgtaa     1140

tggcagctac ggcctgctcg gccttgtatg tgggagatgt gtgcggggcc gtgatgattc     1200

tatcgcaggc tttcatggta tcaccacaac gccacaactt cacccaagag tgcaactgtt     1260

ccatctacca aggtcacatc accggccatc gcatggcatg ggacatgatg ctgaactggt     1320

ctccaactct tgccatgatc ctcgcctacg ccgctcgtgt tcccgagatg gtcctcgaaa     1380

ttattttcgg cggccattgg ggtgtggtgt ttggcttggc ctacttctcc atgcaaggag     1440

cgtgggccaa agtcattgcc atcctccttc ttgttgcggg agtggatgca accacctatt     1500

ccagcggcca ggaagcgggt cgtaccgtct tggggttcac taacctcttt acttctggtg     1560

ccaagcagaa cctctattta atcaacacca atggcagctg gcacataaac cggactgccc     1620

tcaattgcaa tgacagctta cagacgggtt tcatggcttc cctgttttac acccacaggt     1680

tcaacagctc tggctgcccc gagcgcttgt cttcctgccg cgggctggac gattttcgca     1740

tcggctgggg aaccttggaa tacgaaaccc acgtcaccaa cgatgaggac atgaggccgt     1800

actgctggca ttaccctccg aggccttgcg gcatcgtccc ggctagaacg gtttgcggac     1860

cggtctattg tttcacccct agccctgttg tcgtgggcac cactgacaag cagggcgtac     1920

ccacctacac ctggggggaa aacgagaccg atgtcttcct gctgaatagc acaagacccc     1980

cgcgaggagc ttggttcggc tgcacttgga tgaacgggac tgggttcact aagacatgcg     2040

gtgcaccacc ttgccgcatt aggaaagact acaacagcac tatcgattta ttgtgcccca     2100

cagactgttt taggaagcac cccgatgcta cctatcttaa gtgtggagca gggccttggt     2160

taactcccag gtgcctggta gactaccctt atagactgtg gcattatccg tgcactgtaa     2220

acttcaccat ctttaaggcg cggatgtatg taggaggggt ggagcatcga ttctccgcag     2280

catgcaactt cacgcgcgga gatcgctgca gactggaaga tagggatagg ggtcagcaga     2340

gtccactgct gcattccact actgagtggg cggtgctccc atgctccttc tctgacctac     2400

cagcactatc cactggccta ttgcacctcc accaaaacat cgtggacgtg cagtaccttt     2460

acggactttc tccggctctg acaagataca tcgtgaagtg ggagtgggtg atcctccttt     2520

tcttgttgtt ggcagacgcc aggatctgtg catgcctttg gatgctcatc atactgggcc     2580

aagccgaagc ggcgcttgag aagctcatca tcttgcactc cgctagtgct gctagtgcca     2640

atggtccgct gtggtgtttc atcttcttta cagcggcctg gtacttaaag ggcagggtgg     2700

tccccgtggc cacgtactct gttctcggct tatggtcctt cctcctccta gtcctggcct     2760

taccacagca ggcttatgcc ttggacgctg ctgaacaagg ggaactgggg ctggccatat     2820

tagtaattat atccatcttt actcttaccc cagcatacaa gatcctcctg agccgttcag     2880

tgtggtggct gtcctacatg ctggtcttgg ccgaggccca gattcagcaa cgggttcccc     2940

ccctggaggt ccgagggggg cgtgacggaa tcatctgggt ggctgtcatt ctacacccac     3000

gccttgtgtt tgaggtcacg aaatggttgt tagcaatcct ggggcctgcc tacctcctta     3060

aagcgtctct gctacggata ccgtactttg tgagggccca cgctttgcta cgagtgtgta     3120

ccctggtgaa acacctcgcg ggggctaggt acatccagat gctgttgatc accataggca     3180

gatggaccgg cacttacatc tacgaccacc tctccccttt atcaacttgg gcggcccagg     3240

gtttgcggga cctggcaatc gccgtggagc ctgtggtgtt cagcccaatg gagaagaagg     3300

tcattgtgtg gggggctgag acagtggcgt gtggagacat cctgcatggc ctcccggtct     3360

ccgcgaggct aggtagggag gttctgctcg gccctgccga cggctacacc tccaaggggt     3420

ggaagctcct agctcccatt actgcttaca ctcagcaaac tcgtggtctc ctgggtgcta     3480

tcgtggtcag cctaacgggc cgcgacaaaa atgagcaggc tgggcaggtc caggttctgt     3540

cctccgtcac acaaactttc ttggggacat ccatttcggg cgtcctctgg acagtatatc     3600

acggggctgg taataagacc ttggccggcc ccaagggacc agtcactcag atgtacacca     3660

gcgcagaagg ggacctcgtg ggatggccta gtccccccgg gactaagtca ttggacccct     3720

gtacctgcgg ggccgtagac ctctacctgg tcacccgaaa cgctgatgtc attccggtcc     3780

ggaggaaaga tgaccgacgg ggtgcattac tctcgccaag gcccctctca accctcaaag     3840

gatcatccgg agggcccgtg ctctgctcaa ggggacacgc cgtgggcttg ttcagagcgg     3900

ccgtgtgtgc caggggtgta gccaaatcta ttgacttcat ccccgtcgaa tcactcgatg     3960

tcgccacacg gacgcccagt ttctctgaca acagtacgcc gccagctgtg ccccagtctt     4020

accaggtggg ttacttgcac gcaccaacag gcagcggaaa gagcaccaag gtccctgccg     4080

cgtatgccag tcaggggtat aaagtactcg tactaaatcc ctctgtcgcg gccacacttg     4140

gttttggggc ctacatgtcc aaagcccacg ggatcaaccc taatatcaga actggagtgc     4200

ggaccgttac caccggggac tctatcactt actccactta tggcaagttt atcgcagatg     4260

gaggctgtgc agccggtgcc tatgacatca tcatatgcga cgaatgccat tcagtggacg     4320

ctactaccat ccttggcatt ggaacagtcc ttgaccaagc tgagaccgca ggcgtcaggc     4380

tagtggtttt ggccacagcc acgcctcccg gtacggtgac aactccccac agtaacatag     4440

aggaggtggc ccttggtcac gagggcgaga tcccttttta tggcaaagcc attcccctag     4500

ctttcatcaa ggggggcaga cacttgatct tttgccattc aaagaagaag tgcgacgagc     4560

tcgcagcggc cctccggggc atgggtgtca atgccgttgc atactatagg ggtctcgacg     4620

tctccgttat accaactcaa ggagacgtgg tggttgtcgc cactgatgcc ctaatgactg     4680

ggtacaccgg cgactttgac tctgtcatcg actgtaatgt tgcagtctct cagattgttg     4740

acctcagcct agacccaacc ttcaccatca ccactcaaat cgtccctcag gacgctgtct     4800

cccgtagtca acgtagaggg agaactggga gggggcgatt gggcgtttac aggtatgttt     4860

cgtcaggcga aaggccgtct gggatgttcg acagcgtagt gctctgcgag tgctatgatg     4920

ccggggcagc ctggtacgag cttacacctg ctgagactac ggtgagactc cgggcttatt     4980

tcaacacgcc cggtttgccc gtatgtcaag accacctgga gttctgggaa gcggtcttta     5040

caggtctcac acacattgac gcccacttcc tctcccagac gaagcaagga ggagaaaact     5100

ttgcgtatct aacggcctac caggccacag tatgcgccag ggcaaaggcc cctcctcctt     5160

cgtgggacgt gatgtggaag tgtctaacta ggctcaaacc tacactgact ggtcccaccc     5220

ccctcctgta ccgcttgggt gccgtgacca atgaggtcac cttgacgcac cccgtgacga     5280

aatacatcgc cacgtgcatg caagctgacc tcgagatcat gacaagctca tgggtcctgg     5340

cggggggggt gctagccgcc gtggcatctt actgcctggc gactggctgc atttccatca     5400

ttggccgcct acacctgaat gatcgggtgg ttgtggcccc cgacaaggaa atcttatatg     5460

aggcctttga tgagatggaa gaatgcgcct ccaaagccgc cctcattgag gaagggcagc     5520

ggatggcgga gatgctcaaa tctaagatac aaggcctcct acaacaggcc acaaggcaag     5580

ctcaagacat acagccagct atacagtcat catggcccaa gcttgaacaa ttttgggcca     5640

aacacatgtg gaacttcatc agtggtatac agtacctagc aggactctcc accctaccgg     5700

gaaatcctgc agtagcatca atgatggctt ttagcgccgc gctgactagc ccactaccca     5760

ccagcaccac catcctcttg aacatcatgg gaggatggtt ggcctctcag attgcccccc     5820

ctgccggagc cactggcttc gttgtcagtg gtctagtggg ggcggccgtc ggaagcatag     5880

gcctgggtaa gatactggtg gacgttttgg ccgggtacgg cgcaggcatt tcaggggccc     5940

tcgtagcttt taagatcatg agcggcgaga agcccacggt agaagacgtt gtgaatctcc     6000

tgcctgctat tctgtctcct ggtgcgttgg tagtgggagt catctgtgca gcaatcctgc     6060

gccgccacgt cggtcaggga gagggggcgg tccagtggat gaacagactg atcgccttcg     6120

cctccagggg aaaccacgtt gcccctaccc actacgtggt ggagtctgac gcttcacagc     6180

gtgtaacgca ggtgctgagt tcacttacaa ttaccagctt acttaggaga ctacatgcct     6240

ggatcactga agattgccca gtcccatgct cggggtcttg gctccaggac atttgggatt     6300

gggtttgttc catcctcaca gacttcaaaa actggctgtc ttcaaaatta ctccccaaga     6360

tgcccggcat tccctttatc tcttgccaga agggatacaa gggtgtatgg gctggtacgg     6420

gtgtcatgac tactcggtgc ccatgtggag caaacatctc gggccatgtc cgcatgggca     6480

ccatgaaaat aacaggcccg aagacttgct tgaacctgtg gcaggggact ttccccatta     6540

attgttacac agaagggcct tgcgtgccaa aaccccctcc taattacaag accgcaattt     6600

ggagggtggc agcgtcggag tacgttgagg tcacacagca tggctctttc tcgtatgtaa     6660

cagggttaac cagtgacaac cttaaggtcc cttgccaggt accagctcca gaatttttct     6720

cttgggtgga cggggtgcaa atccaccgat tcgcccccgt tccaggtccc ttctttcggg     6780

atgaggtaac gttcaccgta ggccttaact ccttcgtggt cggctctcag ctcccttgcg     6840

atcctgagcc ggacaccgag gtactggcct ccatgttgac agacccgtcc cacatcaccg     6900

cggaggcggc agccaggcga ttggcaaggg gatctccccc ttcacaggct agctcctcag     6960

cgagccagct ctctgccccg tccttgaagg ctacctgtac cacccataag acagcatatg     7020

attgtgacat ggtggatgcc aaccttttca tgggaggcga tgtgacccgg attgagtctg     7080

actctaaggt gatcgttctc gactccctcg attccatgac tgaggtagag gatgatcgtg     7140

agccttctgt accatcagag tacctgatca agaggagaaa gttcccaccg gcgctgcctc     7200

cttgggcccg tccagactac aatcctgttt tgatcgagac atggaagagg ccgggctatg     7260

aaccacccac tgtcctaggc tgtgccctcc cccccacacc tcaaacgcca gtgcctccac     7320

ctcggaggcg ccgcgccaaa gtcctgaccc aggacaatgt ggaggggatc ctcagggaga     7380

tggctgacaa agtactcagc cctctccaag acaacaatga ctccggtcac tccactggag     7440

cggataccgg aggagacatc gtccagcaac cctctgacga gactgccgct tcagaagcgg     7500

ggtcactgtc ctccatgcct ccccttgagg gagagccggg agaccctgac ctggagtttg     7560

aaccagtggg atccgctccc ccttctgagg gggagtgtga ggtcattgat tcggactcta     7620

agtcgtggtc cacagtctct gatcaagagg attctgttat ctgctgctct atgtcatact     7680

cctggacggg ggccctcata acaccatgtg ggcccgaaga ggagaagtta ccgatcaacc     7740

ctctgagtaa ttcgctcatg cggttccata ataaggtgta ctccacaacc tcgaggagtg     7800

cctctctgag ggcaaagaag gtgacttttg acagggtgca ggtgctggac gcacactatg     7860

actcagtctt gcaggacgtt aagcgggccg cctctaaggt tagtgcgagg ctcctcacgg     7920

tagaggaagc ctgcgcgctg accccgcccc actccgccaa atcgcgatac ggatttgggg     7980

caaaagaggt gcgcagctta tccaggaggg ccgttaacca catccggtcc gtgtgggagg     8040

acctcctgga agaccaacat accccaattg acacaactat catggctaaa aatgaggtgt     8100

tctgcattga tccaactaaa ggtgggaaaa agccagctcg cctcatcgta taccccgacc     8160

ttggggtcag ggtgtgcgaa aagatggccc tctatgacat cgcacaaaag cttcccaaag     8220

cgataatggg gccatcctat gggttccaat actctcccgc agaacgggtc gatttcctcc     8280

tcaaagcttg gggaagtaag aaggacccaa tggggttctc gtatgacacc cgctgctttg     8340

actcaaccgt cacggagagg gacataagaa cagaagaatc catatatcag gcttgttctc     8400

tgcctcaaga agccagaact gtcatacact cgctcactga gagactttac gtaggagggc     8460

ccatgacaaa cagcaaaggg caatcctgcg gctacaggcg ttgccgcgca agcggtgttt     8520

tcaccaccag catggggaat accatgacat gttacatcaa agcccttgca gcgtgtaagg     8580

ctgcagggat cgtggaccct gttatgttgg tgtgtggaga cgacctggtc gtcatctcag     8640

agagccaagg taacgaggag gacgagcgaa acctgagagc tttcacggag gctatgacca     8700

ggtattccgc ccctcccggt gaccttccca gaccggaata tgacttggag cttataacat     8760

cctgctcctc aaacgtatcg gtagcgctgg actctcgggg tcgccgccgg tacttcctaa     8820

ccagagaccc taccactcca atcacccgag ctgcttggga aacagtaaga cactcccctg     8880

tcaattcttg gctgggcaac atcatccagt acgcccccac aatctgggtc cggatggtca     8940

taatgactca cttcttctcc atactattgg cccaggacac tctgaaccaa aatctcaatt     9000

ttgagatgta cggggcagta tactcggtca atccattaga cctaccggcc ataattgaaa     9060

ggctacatgg gcttgaagcc ttttcactgc acacatactc tccccgcgaa ctctcacggg     9120

tggcagcaac tctcagaaaa cttggagcgc ctccccttag agcgtggaag agtcgggcgc     9180

gtgccgtgag agcttcactc atcgcccaag gagcgagggc ggccatttgt ggccgctacc     9240

tcttcaactg ggcggtgaaa acaaagctca aactcactcc attgcccgag gcgagccgcc     9300

tggatttatc cgggtggttc accgtgggcg ccggcggggg cggcatttat cacagcgtgt     9360

cgcatgcccg accccgccta ttactccttt gcctactcct acttagcgta ggagtaggca     9420

tctttttact ccccgctcgg tagagcggca aaccctagct acactccata gctagtttcc     9480

gttttttttt ttttgttttt tttttttttt tttttttttt tttttttttt tttcttttcc     9540

tttttttttt ttctctttct tggtggctcc atcttagccc tagtcacggc tagctgtgaa     9600

aggtccgtga gccgcatgac tgcagagagt gccgtaactg gtctctctgc agatcatgt      9659


<210>  53
<211>  9659
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  53
gcccgccccc tgatgggggc gacactccgc catgaatcac tcccctgtga ggaactactg       60

tcttcacgca gaaagcgtct agccatggcg ttagtatgag tgtcgtacag cctccaggcc      120

cccccctccc gggagagcca tagtggtctg cggaaccggt gagtacaccg gaattaccgg      180

aaagactggg tcctttcttg gataaaccca ctctatgtcc ggtcatttgg gcacgccccc      240

gcaagactgc tagccgagta gcgttgggtt gcgaaaggcc ttgtggtact gcctgatagg      300

gtgcttgcga gtgccccggg aggtctcgta gaccgtgcat catgagcaca aatcctaaac      360

ctcaaagaaa aaccaaaaga aacacaaacc gccgcccaca ggacgttaag ttcccgggtg      420

gcggtcagat cgttggcgga gtttacttgc tgccgcgcag gggccccagg ttgggtgtgc      480

gcgcgacaag gaagacttct gagcgatccc agccgcgtgg acgacgccag cccatcccga      540

aagatcggcg ctccaccggc aagtcctggg gaaagccagg atatccttgg cccctgtacg      600

gaaacgaggg ttgcggctgg gcgggttggc tcctgtcccc ccgcgggtct cgtcctactt      660

ggggccccac cgacccccgg catagatcac gcaatttggg cagagtcatc gataccatta      720

cgtgtggttt tgccgacctc atggggtaca tccctgtcgt tggcgccccg gttggaggcg      780

tcgccagagc tctggcacac ggtgttaggg tcctggagga cgggataaat tacgcaacag      840

ggaatttacc cggttgctct ttttctatct ttttgcttgc tcttctgtca tgcgtcacag      900

tgccagtgtc tgcagtggaa gtcaggaaca ttagttctag ctactacgcc actaatgatt      960

gctcaaacaa cagcatcacc tggcagctca ctgacgcagt tctccatctt cctggatgcg     1020

tcccatgtga gaatgataat ggcaccttgc attgctggat acaagtaaca cccaacgtgg     1080

ctgtgaaaca ccgcggtgcg ctcactcgta gcctgcgaac acacgtcgac atgatcgtaa     1140

tggcagctac ggcctgctcg gccttgtatg tgggagatgt gtgcggggcc gtgatgattc     1200

tatcgcaggc tttcatggta tcaccacaac gccacaactt cacccaagag tgcaactgtt     1260

ccatctacca aggtcacatc accggccatc gcatggcatg ggacatgatg ctgaactggt     1320

ctccaactct tgccatgatc ctcgcctacg ccgctcgtgt tcccgagatg gtcctcgaaa     1380

ttattttcgg cggccattgg ggtgtggtgt ttggcttggc ctacttctcc atgcaaggag     1440

cgtgggccaa agtcattgcc atcctccttc ttgttgcggg agtggatgca accacctatt     1500

ccagcggcca ggaagcgggt cgtaccgtct tggggttcac taacctcttt acttctggtg     1560

ccaagcagaa cctctattta atcaacacca atggcagctg gcacataaac cggactgccc     1620

tcaattgcaa tgacagctta cagacgggtt tcatggcttc cctgttttac acccacaggt     1680

tcaacagctc tggctgcccc gagcgcttgt cttcctgccg cgggctggac gattttcgca     1740

tcggctgggg aaccttggaa tacgaaaccc acgtcaccaa cgatgaggac atgaggccgt     1800

actgctggca ttaccctccg aggccttgcg gcatcgtccc ggctagaacg gtttgcggac     1860

cggtctattg tttcacccct agccctgttg tcgtgggcac cactgacaag cagggcgtac     1920

ccacctacac ctggggggaa aacgagaccg atgtcttcct gctgaatagc acaagacccc     1980

cgcgaggagc ttggttcggc tgcacttgga tgaacgggac tgggttcact aagacatgcg     2040

gtgcaccacc ttgccgcatt aggaaagact acaacagcac tatcgattta ttgtgcccca     2100

cagactgttt taggaagcac cccgatgcta cctatcttaa gtgtggagca gggccttggt     2160

taactcccag gtgcctggta gactaccctt atagactgtg gcattatccg tgcactgtaa     2220

acttcaccat ctttaaggcg cggatgtatg taggaggggt ggagcatcga ttctccgcag     2280

catgcaactt cacgcgcgga gatcgctgca gactggaaga tagggatagg ggtcagcaga     2340

gtccactgct gcattccact actgagtggg cggtgctccc atgctccttc tctgacctac     2400

cagcactatc cactggccta ttgcacctcc accaaaacat cgtggacgtg cagtaccttt     2460

acggactttc tccggctctg acaagataca tcgtgaagtg ggagtgggtg atcctccttt     2520

tcttgttgtt ggcagacgcc aggatctgtg catgcctttg gatgctcatc atactgggcc     2580

aagccgaagc ggcgcttgag aagctcatca tcttgcactc cgctagtgct gctagtgcca     2640

atggtccgct gtggtgtttc atcttcttta cagcggcctg gtacttaaag ggcagggtgg     2700

tccccgtggc cacgtactct gttctcggct tatggtcctt cctcctccta gtcctggcct     2760

taccacagca ggcttatgcc ttggacgctg ctgaacaagg ggaactgggg ctggccatat     2820

tagtaattat atccatcttt actcttaccc cagcatacaa gatcctcctg agccgttcag     2880

tgtggtggct gtcctacatg ctggtcttgg ccgaggccca gattcagcaa tgggttcccc     2940

ccctggaggt ccgagggggg cgtgacggaa tcatctgggt ggctgtcatt ctacacccac     3000

gccttgtgtt tgaggtcacg aaatggttgt tagcaatcct ggggcctgcc tacctcctta     3060

aagcgtctct gctacggata ccgtactttg tgagggccca cgctttgcta cgagtgtgta     3120

ccctggtgaa acacctcgcg ggggctaggt acatccagat gctgttgatc accataggca     3180

gatggaccgg cacttacatc tacgaccacc tctccccttt atcaacttgg gcggcccagg     3240

gtttgcggga cctggcaatc gccgtggagc ctgtggtgtt cagcccaatg gagaagaagg     3300

tcattgtgtg gggggctgag acagtggcgt gtggagacat cctgcatggc ctcccggtct     3360

ccgcgaggct aggtagggag gttctgctcg gccctgccga cggctacacc tccaaggggt     3420

ggaagctcct agctcccatt actgcttaca ctcagcaaac tcgtggtctc ctgggtgcta     3480

tcgtggtcag cctaacgggc cgcgacaaaa atgagcaggc tgggcaggtc caggttctgt     3540

cctccgtcac acaaactttc ttggggacat ccatttcggg cgtcctctgg acagtatatc     3600

acggggctgg taataagacc ttggccggcc ccaagggacc agtcactcag atgtacacca     3660

gcgcagaagg ggacctcgtg ggatggccta gtccccccgg gactaagtca ttggacccct     3720

gtacctgcgg ggccgtagac ctctacctgg tcacccgaaa cgctgatgtc attccggtcc     3780

ggaggaaaga tgaccgacgg ggtgcattac tctcgccaag gcccctctca accctcaaag     3840

gatcatccgg agggcccgtg ctctgctcaa ggggacacgc cgtgggcttg ttcagagcgg     3900

ccgtgtgtgc caggggtgta gccaaatcta ttgacttcat ccccgtcgaa tcactcgatg     3960

tcaccacacg gacgcccagt ttctctgaca acagtacgcc gccagctgtg ccccagtctt     4020

accaggtggg ttacttgcac gcaccaacag gcagcggaaa gagcaccaag gtccctgccg     4080

cgtatgccag tcaggggtat aaagtactcg tactaaatcc ctctgtcgcg gccacacttg     4140

gttttggggc ctacatgtcc aaagcccacg ggatcaaccc taatatcaga actggagtgc     4200

ggaccgttac caccggggac tctatcactt actccactta tggcaagttt atcgcagatg     4260

gaggctgtgc agccggtgcc tatgacatca tcatatgcga cgaatgccat tcagtggacg     4320

ctactaccat ccttggcatt ggaacagtcc ttgaccaagc tgagaccgca ggcgtcaggc     4380

tagtggtttt ggccacagcc acgcctcccg gtacggtgac aactccccac agtaacatag     4440

aggaggtggc ccttggtcac gagggcgaga tcccttttta tggcaaagcc attcccctag     4500

ctttcatcaa ggggggcaga cacttgatct tttgccattc aaagaagaag tgcgacgagc     4560

tcgcagcggc cctccggggc atgggtgtca atgccgttgc atactatagg ggtctcgacg     4620

tctccgttat accaactcaa ggagacgtgg tggttgtcgc cactgatgcc ctaatgactg     4680

ggtacaccgg cgactttgac tctgtcatcg actgtaatgt tgcagtctct cagattgttg     4740

acctcagcct agacccaacc ttcaccatca ccactcaaat cgtccctcag gacgctgtct     4800

cccgtagtca acgtagaggg agaactggga gggggcgatt gggcgtttac aggtatgttt     4860

cgtcaggcga aaggccgtct gggatgttcg acagcgtagt gctctgcgag tgctatgatg     4920

ccggggcagc ctggtacgag cttacacctg ctgagactac ggtgagactc cgggcttatt     4980

tcaacacgcc cggtttgccc gtatgtcaag accacctgga gttctgggaa gcggtcttta     5040

caggtctcac acacattgac gcccacttcc tctcccagac gaagcaagga ggagaaaact     5100

ttgcgtatct aacggcctac caggccacag tatgcgccag ggcaaaggcc cctcctcctt     5160

cgtgggacgt gatgtggaag tgtctaacta ggctcaaacc tacactgact ggtcccaccc     5220

ccctcctgta ccgcttgggt gccgtgacca atgaggtcac cttgacgcac cccgtgacga     5280

aatacatcgc cacgtgcatg caagctgacc tcgagatcat gacaagctca tgggtcctgg     5340

cggggggggt gctagccgcc gtggcatctt actgcctggc gactggctgc atttccatca     5400

ttggccgcct acacctgaat gatcgggtgg ttgtggcccc cgacaaggaa atcttatatg     5460

aggcctttga tgagatggaa gaatgcgcct ccaaagccgc cctcattgag gaagggcagc     5520

ggatggcgga gatgctcaaa tctaagatac aaggcctcct acaacaggcc acaaggcaag     5580

ctcaagacat acagccagct atacagtcat catggcccaa gcttgaacaa ttttgggcca     5640

aacacatgtg gaacttcatc agtggtatac agtacctagc aggactctcc accctaccgg     5700

gaaatcctgc agtagcatca atgatggctt ttagcgccgc gctgactagc ccactaccca     5760

ccagcaccac catcctcttg aacatcatgg gaggatggtt ggcctctcag attgcccccc     5820

ctgccggagc cactggcttc gttgtcagtg gtctagtggg ggcggccgtc ggaagcatag     5880

gcctgggtaa gatactggtg gacgttttgg ccgggtacgg cgcaggcatt tcaggggccc     5940

tcgtagcttt taagatcatg agcggcgaga agcccacggt agaagacgtt gtgaatctcc     6000

tgcctgctat tctgtctcct ggtgcgttgg tagtgggagt catctgtgca gcaatcctgc     6060

gccgccacgt cggtcaggga gagggggcgg tccagtggat gaacagactg atcgccttcg     6120

cctccagggg aaaccacgtt gcccctaccc actacgtggt ggagtctgac gcttcacagc     6180

gtgtaacgca ggtgctgagt tcacttacaa ttaccagctt acttaggaga ctacatgcct     6240

gggtcactga agattgccca gtcccatgct cggggtcttg gctccaggac atttgggatt     6300

gggtttgttc catcctcaca gacttcaaaa actggctgtc ttcaaaatta ctccccaaga     6360

tgcccggcat tccctttatc tcttgccaga agggatacaa gggtgtatgg gctggtacgg     6420

gtgtcatgac tactcggtgc ccatgtggag caaacatctc gggccatgtc cgcatgggca     6480

ccatgaaaat aacaggcccg aagacttgct tgaacctgtg gcaggggact ttccccatta     6540

attgttacac agaagggcct tgcgtgccaa aaccccctcc taattacaag accgcaattt     6600

ggagggtggc agcgtcggag tacgttgagg tcacacagca tggctctttc tcgtatgtaa     6660

cagggttaac cagtgacaac cttaaggtcc cttgccaggt accagctcca gaatttttct     6720

cttgggtgga cggggtgcaa atccaccgat tcgcccccgt tccaggtccc ttctttcggg     6780

atgaggtaac gttcaccgta ggccttaact ccttcgtggt cggctctcag ctcccttgcg     6840

atcctgagcc ggacaccgag gtactggcct ccatgttgac agacccgtcc cacatcaccg     6900

cggaggcggc agccaggcga ttggcaaggg gatctccccc ttcacaggct agctcctcag     6960

cgagccagct ctctgccccg tccttgaagg ctacctgtac cacccataag acagcatatg     7020

attgtgacat ggtggatgcc aaccttttca tgggaggcga tgtgacccgg attgagtctg     7080

actctaaggt gatcgttctc gactccctcg attccatgac tgaggtagag gatgatcgtg     7140

agccttctgt accatcagag tacctgatca agaggagaaa gttcccaccg gcgctgcctc     7200

cttgggcccg tccagactac aatcctgttt tgatcgagac atggaagagg ccgggctatg     7260

aaccacccac tgtcctaggc tgtgccctcc cccccacacc tcaaacgcca gtgcctccac     7320

ctcggaggcg ccgcgccaaa gtcctgaccc aggacaatgt ggaggggatc ctcagggaga     7380

tggctgacaa agtactcagc cctctccaag acaacaatga ctccggtcac tccactggag     7440

cggataccgg aggagacatc gtccagcaac cctctgacga gactgccgct tcagaagcgg     7500

ggtcactgtc ctccatgcct ccccttgagg gagagccggg agaccctgac ctggagtttg     7560

aaccagtggg atccgctccc ccttctgagg gggagtgtga ggtcattgat tcggactcta     7620

agtcgtggtc cacagtctct gatcaagagg attctgttat ctgctgctct atgtcatact     7680

cctggacggg ggccctcata acaccatgtg ggcccgaaga ggagaagtta ccgatcaacc     7740

ctctgagtaa ttcgctcatg cggttccata ataaggtgta ctccacaacc tcgaggagtg     7800

cctctctgag ggcaaagaag gtgacttttg acagggtgca ggtgctggac gcacactatg     7860

actcagtctt gcaggacgtt aagcgggccg cctctaaggt tagtgcgagg ctcctcacgg     7920

tagaggaagc ctgcgcgctg accccgcccc actccgccaa atcgcgatac ggatttgggg     7980

caaaagaggt gcgcagctta tccaggaggg ccgttaacca catccggtcc gtgtgggagg     8040

acctcctgga agaccaacat accccaattg acacaactat catggctaaa aatgaggtgt     8100

tctgcattga tccaactaaa ggtgggaaaa agccagctcg cctcatcgta taccccgacc     8160

ttggggtcag ggtgtgcgaa aagatggccc tctatgacat cgcacaaaag cttcccaaag     8220

cgataatggg gccatcctat gggttccaat actctcccgc agaacgggtc gatttcctcc     8280

tcaaagcttg gggaagtaag aaggacccaa tggggttctc gtatgacacc cgctgctttg     8340

actcaaccgt cacggagagg gacataagaa cagaagaatc catatatcag gcttgttctc     8400

tgcctcaaga agccagaact gtcatacact cgctcactga gagactttac gtaggagggc     8460

ccatgacaaa cagcaaaggg caatcctgcg gctacaggcg ttgccgcgca agcggtgttt     8520

tcaccaccag catggggaat accatgacat gttacatcaa agcccttgca gcgtgtaagg     8580

ctgcagggat cgtggaccct gttatgttgg tgtgtggaga cgacctggtc gtcatctcag     8640

agagccaagg taacgaggag gacgagcgaa acctgagagc tttcacggag gctatgacca     8700

ggtattccgc ccctcccggt gaccttccca gaccggaata tgacttggag cttataacat     8760

cctgctcctc aaacgtatcg gtagcgctgg actctcgggg tcgccgccgg tacttcctaa     8820

ccagagaccc taccactcca atcacccgag ctgcttggga aacagtaaga cactcccctg     8880

tcaattcttg gctgggcaac atcatccagt acgcccccac aatctgggtc cggatggtca     8940

taatgactca cttcttctcc atactattgg cccaggacac tctgaaccaa aatctcaatt     9000

ttgagatgta cggggcagta tactcggtca atccattaga cctaccggcc ataattgaaa     9060

ggctacatgg gcttgaagcc ttttcactgc acacatactc tccccgcgaa ctctcacggg     9120

tggcagcaac tctcagaaaa cttggagcgc ctccccttag agcgtggaag agtcgggcgc     9180

gtgccgtgag agcttcactc atcgcccaag gagcgagggc ggccatttgt ggccgctacc     9240

tcttcaactg ggcggtgaaa acaaagctca aactcactcc attgcccgag gcgagccgcc     9300

tggatttatc cgggtggttc accgtgggcg ccggcggggg cggcatttat cacagcgtgt     9360

cgcatgcccg accccgccta ttactccttt gcctactcct acttagcgta ggagtaggca     9420

tctttttact ccccgctcgg tagagcggca aaccctagct acactccata gctagtttcc     9480

gttttttttt ttttgttttt tttttttttt tttttttttt tttttttttt tttcttttcc     9540

tttttttttt ttctctttct tggtggctcc atcttagccc tagtcacggc tagctgtgaa     9600

aggtccgtga gccgcatgac tgcagagagt gccgtaactg gtctctctgc agatcatgt      9659


<210>  54
<211>  9659
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  54
gcccgccccc tgatgggggc gacactccgc catgaatcac tcccctgtga ggaactactg       60

tcttcacgca gaaagcgtct agccatggcg ttagtatgag tgtcgtacag cctccaggcc      120

cccccctccc gggagagcca tagtggtctg cggaaccggt gagtacaccg gaattaccgg      180

aaagactggg tcctttcttg gataaaccca ctctatgtcc ggtcatttgg gcacgccccc      240

gcaagactgc tagccgagta gcgttgggtt gcgaaaggcc ttgtggtact gcctgatagg      300

gtgcttgcga gtgccccggg aggtctcgta gaccgtgcat catgagcaca aatcctaaac      360

ctcaaagaaa aaccaaaaga aacacaaacc gccgcccaca ggacgttaag ttcccgggtg      420

gcggtcagat cgttggcgga gtttacttgc tgccgcgcag gggccccagg ttgggtgtgc      480

gcgcgacaag gaagacttct gagcgatccc agccgcgtgg acgacgccag cccatcccga      540

aagatcggcg ctccaccggc aagtcctggg gaaagccagg atatccttgg cccctgtacg      600

gaaacgaggg ttgcggctgg gcgggttggc tcctgtcccc ccgcgggtct cgtcctactt      660

ggggccccac cgacccccgg catagatcac gcaatttggg cagagtcatc gataccatta      720

cgtgtggttt tgccgacctc atggggtaca tccctgtcgt tggcgccccg gttggaggcg      780

tcgccagagc tctggcacac ggtgttaggg tcctggagga cgggataaat tacgcaacag      840

ggaatttacc cggttgctct ttttctatct ttttgcttgc tcttctgtca tgcgtcacag      900

tgccagtgtc tgcagtggaa gtcaggaaca ttagttctag ctactacgcc actaatgatt      960

gctcaaacaa cagcatcacc tggcagctca ctgacgcagt tctccatctt cctggatgcg     1020

tcccatgtga gaatgataat ggcaccttgc attgctggat acaagtaaca cccaacgtgg     1080

ctgtgaaaca ccgcggtgcg ctcactcgta gcctgcgaac acacgtcgac atgatcgtaa     1140

tggcagctac ggcctgctcg gccttgtatg tgggagatgt gtgcggggcc gtgatgattc     1200

tatcgcaggc tttcatggta tcaccacaac gccacaactt cacccaagag tgcaactgtt     1260

ccatctacca aggtcacatc accggccatc gcatggcatg ggacatgatg ctgaactggt     1320

ctccaactct tgccatgatc ctcgcctacg ccgctcgtgt tcccgagatg gtcctcgaaa     1380

ttattttcgg cggccattgg ggtgtggtgt ttggcttggc ctacttctcc atgcaaggag     1440

cgtgggccaa agtcattgcc atcctccttc ttgttgcggg agtggatgca accacctatt     1500

ccagcggcca ggaagcgggt cgtaccgtct tggggttcac taacctcttt acttctggtg     1560

ccaagcagaa cctctattta atcaacacca atggcagctg gcacataaac cggactgccc     1620

tcaattgcaa tgacagctta cagacgggtt tcatggcttc cctgttttac acccacaggt     1680

tcaacagctc tggctgcccc gagcgcttgt cttcctgccg cgggctggac gattttcgca     1740

tcggctgggg aaccttggaa tacgaaaccc acgtcaccaa cgatgaggac atgaggccgt     1800

actgctggca ttaccctccg aggccttgcg gcatcgtccc ggctagaacg gtttgcggac     1860

cggtctattg tttcacccct agccctgttg tcgtgggcac cactgacaag cagggcgtac     1920

ccacctacac ctggggggaa aacgagaccg atgtcttcct gctgaatagc acaagacccc     1980

cgcgaggagc ttggttcggc tgcacttgga tgaacgggac tgggttcact aagacatgcg     2040

gtgcaccacc ttgccgcatt aggaaagact acaacagcac tatcgattta ttgtgcccca     2100

cagactgttt taggaagcac cccgatgcta cctatcttaa gtgtggagca gggccttggt     2160

taactcccag gtgcctggta gactaccctt atagactgtg gcattatccg tgcactgtaa     2220

acttcaccat ctttaaggcg cggatgtatg taggaggggt ggagcatcga ttctccgcag     2280

catgcaactt cacgcgcgga gatcgctgca gactggaaga tagggatagg ggtcagcaga     2340

gtccactgct gcattccact actgagtggg cggtgctccc atgctccttc tctgacctac     2400

cagcactatc cactggccta ttgcacctcc accaaaacat cgtggacgtg cagtaccttt     2460

acggactttc tccggctctg acaagataca tcgtgaagtg ggagtgggtg atcctccttt     2520

tcttgttgtt ggcagacgcc aggatctgtg catgcctttg gatgctcatc atactgggcc     2580

aagccgaagc ggcgcttgag aagctcatca tcttgcactc cgctagtgct gctagtgcca     2640

atggtccgct gtggtgtttc atcttcttta cagcggcctg gtacttaaag ggcagggtgg     2700

tccccgtggc cacgtactct gttctcggct tatggtcctt cctcctccta gtcctggcct     2760

taccacagca ggcttatgcc ttggacgctg ctgaacaagg ggaactgggg ctggccatat     2820

tagtaattat atccatcttt actcttaccc cagcatacaa gatcctcctg agccgttcag     2880

tgtggtggct gtcctacatg ctggtcttgg ccgaggccca gattcagcaa tgggttcccc     2940

ccctggaggt ccgagggggg cgtgacggaa tcatctgggt ggctgtcatt ctacacccac     3000

gccttgtgtt tgaggtcacg aaatggttgt tagcaatcct ggggcctgcc tacctcctta     3060

aagcgtctct gctacggata ccgtactttg tgagggccca cgctttgcta cgagtgtgta     3120

ccctggtgaa acacctcgcg ggggctaggt acatccagat gctgttgatc accataggca     3180

gatggaccgg cacttacatc tacgaccacc tctccccttt atcaacttgg gcggcccagg     3240

gtttgcggga cctggcaatc gccgtggagc ctgtggtgtt cagcccaatg gagaagaagg     3300

tcattgtgtg gggggctgag acagtggcgt gtggagacat cctgcatggc ctcccggtct     3360

ccgcgaggct aggtagggag gttctgctcg gccctgccga cggctacacc tccaaggggt     3420

ggaagctcct agctcccatt actgcttaca ctcagcaaac tcgtggtctc ctgggtgcta     3480

tcgtggtcag cctaacgggc cgcgacaaaa atgagcaggc tgggcaggtc caggttctgt     3540

cctccgtcac acaaactttc ttggggacat ccatttcggg cgtcctctgg acagtatatc     3600

acggggctgg taataagacc ttggccggcc ccaagggacc agtcactcag atgtacacca     3660

gcgcagaagg ggacctcgtg ggatggccta gtccccccgg gactaagtca ttggacccct     3720

gtacctgcgg ggccgtagac ctctacctgg tcacccgaaa cgctgatgtc attccggtcc     3780

ggaggaaaga tgaccgacgg ggtgcattac tctcgccaag gcccctctca accctcaaag     3840

gatcatccgg agggcccgtg ctctgctcaa ggggacacgc cgtgggcttg ttcagagcgg     3900

ccgtgtgtgc caggggtgta gccaaatcta ttgacttcat ccccgtcgaa tcactcgatg     3960

tcaccacacg gacgcccagt ttctctgaca acagtacgcc gccagctgtg ccccagtctt     4020

accaggtggg ttacttgcac gcaccaacag gcagcggaaa gagcaccaag gtccctgccg     4080

cgtatgccag tcaggggtat aaagtactcg tactaaatcc ctctgtcgcg gccacacttg     4140

gttttggggc ctacatgtcc aaagcccacg ggatcaaccc taatatcaga actggagtgc     4200

ggaccgttac caccggggac tctatcactt actccactta tggcaagttt atcgcagatg     4260

gaggctgtgc agccggtgcc tatgacatca tcatatgcga cgaatgccat tcagtggacg     4320

ctactaccat ccttggcatt ggaacagtcc ttgaccaagc tgagaccgca ggcgtcaggc     4380

tagtggtttt ggccacagcc acgcctcccg gtacggtgac aactccccac agtaacatag     4440

aggaggtggc ccttggtcac gagggcgaga tcccttttta tggcaaagcc attcccctag     4500

ctttcatcaa ggggggcaga cacttgatct tttgccattc aaagaagaag tgcgacgagc     4560

tcgcagcggc cctccggggc atgggtgtca atgccgttgc atactatagg ggtctcgacg     4620

tctccgttat accaactcaa ggagacgtgg tggttgtcgc cactgatgcc ctaatgactg     4680

ggtacaccgg cgactttgac tctgtcatcg actgtaatgt tgcagtctct cagattgttg     4740

acctcagcct agacccaacc ttcaccatca ccactcaaat cgtccctcag gacgctgtct     4800

cccgtagtca acgtagaggg agaactggga gggggcgatt gggcgtttac aggtatgttt     4860

cgtcaggcga aaggccgtct gggatgttcg acagcgtagt gctctgcgag tgctatgatg     4920

ccggggcagc ctggtacgag cttacacctg ctgagactac ggtgagactc cgggcttatt     4980

tcaacacgcc cggtttgccc gtatgtcaag accacctgga gttctgggaa gcggtcttta     5040

caggtctcac acacattgac gcccacttcc tctcccagac gaagcaagga ggagaaaact     5100

ttgcgtatct aacggcctac caggccacag tatgcgccag ggcaaaggcc cctcctcctt     5160

cgtgggacgt gatgtggaag tgtctaacta ggctcaaacc tacactgact ggtcccaccc     5220

ccctcctgta ccgcttgggt gccgtgacca atgaggtcac cttgacgcac cccgtgacga     5280

aatacatcgc cacgtgcatg caagctgacc tcgagatcat gacaagctca tgggtcctgg     5340

cggggggggt gctagccgcc gtggcatctt actgcctggc gactggctgc atttccatca     5400

ttggccgcct acacctgaat gatcgggtgg ttgtggcccc cgacaaggaa atcttatatg     5460

aggcctttga tgagatggaa gaatgcgcct ccaaagccgc cctcattgag gaagggcagc     5520

ggatggcgga gatgctcaaa tctaagatac aaggcctcct acaacaggcc acaaggcaag     5580

ctcaagacat acagccagct atacagtcat catggcccaa gcttgaacaa ttttgggcca     5640

aacacatgtg gaacttcatc agtggtatac agtacctagc aggactctcc accctaccgg     5700

gaaatcctgc agtagcatca atgatggctt ttagcgccgc gctgactagc ccactaccca     5760

ccagcaccac catcctcttg aacatcatgg gaggatggtt ggcctctcag attgcccccc     5820

ctgccggagc cactggcttc gttgtcagtg gtctagtggg ggcggccgtc ggaagcatag     5880

gcctgggtaa gatactggtg gacgttttgg ccgggtacgg cgcaggcatt tcaggggccc     5940

tcgtagcttt taagatcatg agcggcgaga agcccacggt agaagacgtt gtgaatctcc     6000

tgcctgctat tctgtctcct ggtgcgttgg tagtgggagt catctgtgca gcaatcctgc     6060

gccgccacgt cggtcaggga gagggggcgg tccagtggat gaacagactg atcgccttcg     6120

cctccagggg aaaccacgtt gcccctaccc actacgtggt ggagtctgac gcttcacagc     6180

gtgtaacgca ggtgctgagt tcacttacaa ttaccagctt acttaggaga ctacatgcct     6240

gggtcactga agattgccca gtcccatgct cggggtcttg gctccaggac atttgggatt     6300

gggtttgttc catcctcaca gacttcaaaa actggctgtc ttcaaaatta ctccccaaga     6360

tgcccggcat tccctttatc tcttgccaga agggatacaa gggtgtatgg gctggtacgg     6420

gtgtcatgac tactcggtgc ccatgtggag caaacatctc gggccatgtc cgcatgggca     6480

ccatgaaaat aacaggcccg aagacttgct tgaacctgtg gcaggggact ttccccatta     6540

attgttacac agaagggcct tgcgtgccaa aaccccctcc taattacaag accgcaattt     6600

ggagggtggc agcgtcggag tacgttgagg tcacacagca tggctctttc tcgtatgtaa     6660

cagggttaac cagtgacaac cttaaggtcc cttgccaggt accagctcca gaatttttct     6720

cttgggtgga cggggtgcaa atccaccgat tcgcccccgt tccaggtccc ttctttcggg     6780

atgaggtaac gttcaccgta ggccttaact ccttcgtggt cggctctcag ctcccttgcg     6840

atcctgagcc ggacaccgag gtactggcct ccatgttgac agacccgtcc cacatcaccg     6900

cggaggcggc agccaggcga ttggcaaggg gatctccccc ttcacaggct agctcctcag     6960

cgagccagct ctctgccccg tccttgaagg ctacctgtac cacccataag acagcatatg     7020

attgtgacat ggtggatgcc aaccttttca tgggaggcga tgtgacccgg attgagtctg     7080

actctaaggt gatcgttctc gactccctcg attccatgac tgaggtagag gatgatcgtg     7140

agccttctgt accatcagag tacctgatca agaggagaaa gttcccaccg gcgctgcctc     7200

cttgggcccg tccagactac aatcctgttt tgatcgagac atggaagagg ccgggctatg     7260

aaccacccac tgtcctaggc tgtgccctcc cccccacacc tcaaacgcca gtgcctccac     7320

ctcggaggcg ccgcgccaaa gtcctgaccc aggacaatgt ggaggggatc ctcagggaga     7380

tggctgacaa agtactcagc cctctccaag acaacaatga ctccggtcac tccactggag     7440

cggataccgg aggagacatc gtccagcaac cctctgacga gactgccgct tcagaagcgg     7500

ggtcactgtc ctccatgcct ccccttgagg gagagccggg agaccctgac ctggagtttg     7560

aaccagtggg atccgctccc ccttctgagg gggagtgtga ggtcattgat tcggactcta     7620

agtcgtggtc cacagtctct gatcaagagg attctgttat ctgctgctct atgtcatact     7680

cctggacggg ggccctcata acaccatgtg ggcccgaaga ggagaagtta ccgatcaacc     7740

ctctgagtaa ttcgctcatg cggttccata ataaggtgta ctccacaacc tcgaggagtg     7800

cctctctgag ggcaaagaag gtgacttttg acagggtgca ggtgctggac gcacactatg     7860

actcagtctt gcaggacgtt aagcgggccg cctctaaggt tagtgcgagg ctcctcacgg     7920

tagaggaagc ctgcgcgctg accccgcccc actccgccaa atcgcgatac ggatttgggg     7980

caaaagaggt gcgcagctta tccaggaggg ccgttaacca catccggtcc gtgtgggagg     8040

acctcctgga agaccaacat accccaattg acacaactat catggctaaa aatgaggtgt     8100

tctgcattga tccaactaaa ggtgggaaaa agccagctcg cctcatcgta taccccgacc     8160

ttggggtcag ggtgtgcgaa aagatggccc tctatgacat cgcacaaaag cttcccaaag     8220

cgataatggg gccatcctat gggttccaat actctcccgc agaacgggtc gatttcctcc     8280

tcaaagcttg gggaagtaag aaggacccaa tggggttctc gtatgacacc cgctgctttg     8340

actcaaccgt cacggagagg gacataagaa cagaagaatc catatatcag gcttgttctc     8400

tgcctcaaga agccagaact gtcatacact cgctcactga gagactttac gtaggagggc     8460

ccatgacaaa cagcaaaggg caatcctgcg gctacaggcg ttgccgcgca agcggtgttt     8520

tcaccaccag catggggaat accatgacat gttacatcaa agcccttgca gcgtgtaagg     8580

ctgcagggat cgtggaccct gttatgttgg tgtgtggaga cgacctggtc gtcatctcag     8640

agagccaagg taacgaggag gacgagcgaa acctgagagc tttcacggag gctatgacca     8700

ggtattccgc ccctcccggt gaccttccca gaccggaata tgacttggag cttataacat     8760

cctgctcctc aaacgtatcg gtagcgctgg actctcgggg tcgccgccgg tacttcctaa     8820

ccagagaccc taccactcca atcacccgag ctgcttggga aacagtaaga cactcccctg     8880

tcaattcttg gctgggcaac atcatccagt acgcccccac aatctgggtc cggatggtca     8940

taatgactca cttcttctcc atactattgg cccaggacac tctgaaccaa aatctcaatt     9000

ttgagatgta cggggcagta tactcggtca gtccattaga cctaccggcc ataattgaaa     9060

ggctacatgg gcttgaagcc ttttcactgc acacatactc tccccgcgaa ctctcacggg     9120

tggcagcaac tctcagaaaa cttggagcgc ctccccttag agcgtggaag agtcgggcgc     9180

gtgccgtgag agcttcactc atcgcccaag gagcgagggc ggccatttgt ggccgctacc     9240

tcttcaactg ggcggtgaaa acaaagctca aactcactcc attgcccgag gcgagccgcc     9300

tggatttatc cgggtggttc accgtgggcg ccggcggggg cggcatttat cacagcgtgt     9360

cgcatgcccg accccgccta ttactccttt gcctactcct acttagcgta ggagtaggca     9420

tctttttact ccccgctcgg tagagcggca aaccctagct acactccata gctagtttcc     9480

gttttttttt ttttgttttt tttttttttt tttttttttt tttttttttt tttcttttcc     9540

tttttttttt ttctctttct tggtggctcc atcttagccc tagtcacggc tagctgtgaa     9600

aggtccgtga gccgcatgac tgcagagagt gccgtaactg gtctctctgc agatcatgt      9659


<210>  55
<211>  9659
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  55
gcccgccccc tgatgggggc gacactccgc catgaatcac tcccctgtga ggaactactg       60

tcttcacgca gaaagcgtct agccatggcg ttagtatgag tgtcgtacag cctccaggcc      120

cccccctccc gggagagcca tagtggtctg cggaaccggt gagtacaccg gaattaccgg      180

aaagactggg tcctttcttg gataaaccca ctctatgtcc ggtcatttgg gcacgccccc      240

gcaagactgc tagccgagta gcgttgggtt gcgaaaggcc ttgtggtact gcctgatagg      300

gtgcttgcga gtgccccggg aggtctcgta gaccgtgcat catgagcaca aatcctaaac      360

ctcaaagaaa aaccaaaaga aacacaaacc gccgcccaca ggacgttaag ttcccgggtg      420

gcggtcagat cgttggcgga gtttacttgc tgccgcgcag gggccccagg ttgggtgtgc      480

gcgcgacaag gaagacttct gagcgatccc agccgcgtgg acgacgccag cccatcccga      540

aagatcggcg ctccaccggc aagtcctggg gaaagccagg atatccttgg cccctgtacg      600

gaaacgaggg ttgcggctgg gcgggttggc tcctgtcccc ccgcgggtct cgtcctactt      660

ggggccccac cgacccccgg catagatcac gcaatttggg cagagtcatc gataccatta      720

cgtgtggttt tgccgacctc atggggtaca tccctgtcgt tggcgccccg gttggaggcg      780

tcgccagagc tctggcacac ggtgttaggg tcctggagga cgggataaat tacgcaacag      840

ggaatttacc cggttgctct ttttctatct ttttgcttgc tcttctgtca tgcgtcacag      900

tgccagtgtc tgcagtggaa gtcaggaaca ttagttctag ctactacgcc actaatgatt      960

gctcaaacaa cagcatcacc tggcagctca ctgacgcagt tctccatctt cctggatgcg     1020

tcccatgtga gaatgataat ggcaccttgc attgctggat acaagtaaca cccaacgtgg     1080

ctgtgaaaca ccgcggtgcg ctcactcgta gcctgcgaac acacgtcgac atgatcgtaa     1140

tggcagctac ggcctgctcg gccttgtatg tgggagatgt gtgcggggcc gtgatgattc     1200

tatcgcaggc tttcatggta tcaccacaac gccacaactt cacccaagag tgcaactgtt     1260

ccatctacca aggtcacatc accggccatc gcatggcatg ggacatgatg ctgaactggt     1320

ctccaactct tgccatgatc ctcgcctacg ccgctcgtgt tcccgagatg gtcctcgaaa     1380

ttattttcgg cggccattgg ggtgtggtgt ttggcttggc ctacttctcc atgcaaggag     1440

cgtgggccaa agtcattgcc atcctccttc ttgttgcggg agtggatgca accacctatt     1500

ccagcggcca ggaagcgggt cgtaccgtct tggggttcac taacctcttt acttctggtg     1560

ccaagcagaa cctctattta atcaacacca atggcagctg gcacataaac cggactgccc     1620

tcaattgcaa tgacagctta cagacgggtt tcatggcttc cctgttttac acccacaggt     1680

tcaacagctc tggctgcccc gagcgcttgt cttcctgccg cgggctggac gattttcgca     1740

tcggctgggg aaccttggaa tacgaaaccc acgtcaccaa cgatgaggac atgaggccgt     1800

actgctggca ttaccctccg aggccttgcg gcatcgtccc ggctagaacg gtttgcggac     1860

cggtctattg tttcacccct agccctgttg tcgtgggcac cactgacaag cagggcgtac     1920

ccacctacac ctggggggaa aacgagaccg atgtcttcct gctgaatagc acaagacccc     1980

cgcgaggagc ttggttcggc tgcacttgga tgaacgggac tgggttcact aagacatgcg     2040

gtgcaccacc ttgccgcatt aggaaagact acaacagcac tatcgattta ttgtgcccca     2100

cagactgttt taggaagcac cccgatgcta cctatcttaa gtgtggagca gggccttggt     2160

taactcccag gtgcctggta gactaccctt atagactgtg gcattatccg tgcactgtaa     2220

acttcaccat ctttaaggcg cggatgtatg taggaggggt ggagcatcga ttctccgcag     2280

catgcaactt cacgcgcgga gatcgctgca gactggaaga tagggatagg ggtcagcaga     2340

gtccactgct gcattccact actgagtggg cggtgctccc atgctccttc tctgacctac     2400

cagcactatc cactggccta ttgcacctcc accaaaacat cgtggacgtg cagtaccttt     2460

acggactttc tccggctctg acaagataca tcgtgaagtg ggagtgggtg atcctccttt     2520

tcttgttgtt ggcagacgcc aggatctgtg catgcctttg gatgctcatc atactgggcc     2580

aagccgaagc ggcgcttgag aagctcatca tcttgcactc cgctagtgct gctagtgcca     2640

atggtccgct gtggtgtttc atcttcttta cagcggcctg gtacttaaag ggcagggtgg     2700

tccccgtggc cacgtactct gttctcggct tatggtcctt cctcctccta gtcctggcct     2760

taccacagca ggcttatgcc ttggacgctg ctgaacaagg ggaactgggg ctggccatat     2820

tagtaattat atccatcttt actcttaccc cagcatacaa gatcctcctg agccgttcag     2880

tgtggtggct gtcctacatg ctggtcttgg ccgaggccca gattcagcaa cgggttcccc     2940

ccctggaggt ccgagggggg cgtgacggaa tcatctgggt ggctgtcatt ctacacccac     3000

gccttgtgtt tgaggtcacg aaatggttgt tagcaatcct ggggcctgcc tacctcctta     3060

aagcgtctct gctacggata ccgtactttg tgagggccca cgctttgcta cgagtgtgta     3120

ccctggtgaa acacctcgcg ggggctaggt acatccagat gctgttgatc accataggca     3180

gatggaccgg cacttacatc tacgaccacc tctccccttt atcaacttgg gcggcccagg     3240

gtttgcggga cctggcaatc gccgtggagc ctgtggtgtt cagcccaatg gagaagaagg     3300

tcattgtgtg gggggctgag acagtggcgt gtggagacat cctgcatggc ctcccggtct     3360

ccgcgaggct aggtagggag gttctgctcg gccctgccga cggctacacc tccaaggggt     3420

ggaagctcct agctcccatt actgcttaca ctcagcaaac tcgtggtctc ctgggtgcta     3480

tcgtggtcag cctaacgggc cgcgacaaaa atgagcaggc tgggcaggtc caggttctgt     3540

cctccgtcac acaaactttc ttggggacat ccatttcggg cgtcctctgg acagtatatc     3600

acggggctgg taataagacc ttggccggcc ccaagggacc agtcactcag atgtacacca     3660

gcgcagaagg ggacctcgtg ggatggccta gtccccccgg gactaagtca ttggacccct     3720

gtacctgcgg ggccgtagac ctctacctgg tcacccgaaa cgctgatgtc attccggtcc     3780

ggaggaaaga tgaccgacgg ggtgcattac tctcgccaag gcccctctca accctcaaag     3840

gatcatccgg agggcccgtg ctctgctcaa ggggacacgc cgtgggcttg ttcagagcgg     3900

ccgtgtgtgc caggggtgta gccaaatcta ttgacttcat ccccgtcgaa tcactcgatg     3960

tcgccacacg gacgcccagt ttctctgaca acagtacgcc gccagctgtg ccccagtctt     4020

accaggtggg ttacttgcac gcaccaacag gcagcggaaa gagcaccaag gtccctgccg     4080

cgtatgccag tcaggggtat aaagtactcg tactaaatcc ctctgtcgcg gccacacttg     4140

gttttggggc ctacatgtcc aaagcccacg ggatcaaccc taatatcaga actggagtgc     4200

ggaccgttac caccggggac tctatcactt actccactta tggcaagttt atcgcagatg     4260

gaggctgtgc agccggtgcc tatgacatca tcatatgcga cgaatgccat tcagtggacg     4320

ctactaccat ccttggcatt ggaacagtcc ttgaccaagc tgagaccgca ggcgtcaggc     4380

tagtggtttt ggccacagcc acgcctcccg gtacggtgac aactccccac agtaacatag     4440

aggaggtggc ccttggtcac gagggcgaga tcccttttta tggcaaagcc attcccctag     4500

ctttcatcaa ggggggcaga cacttgatct tttgccattc aaagaagaag tgcgacgagc     4560

tcgcagcggc cctccggggc atgggtgtca atgccgttgc atactatagg ggtctcgacg     4620

tctccgttat accaactcaa ggagacgtgg tggttgtcgc cactgatgcc ctaatgactg     4680

ggtacaccgg cgactttgac tctgtcatcg actgtaatgt tgcagtctct cagattgttg     4740

acctcagcct agacccaacc ttcaccatca ccactcaaat cgtccctcag gacgctgtct     4800

cccgtagtca acgtagaggg agaactggga gggggcgatt gggcgtttac aggtatgttt     4860

cgtcaggcga aaggccgtct gggatgttcg acagcgtagt gctctgcgag tgctatgatg     4920

ccggggcagc ctggtacgag cttacacctg ctgagactac ggtgagactc cgggcttatt     4980

tcaacacgcc cggtttgccc gtatgtcaag accacctgga gttctgggaa gcggtcttta     5040

caggtctcac acacattgac gcccacttcc tctcccagac gaagcaagga ggagaaaact     5100

ttgcgtatct aacggcctac caggccacag tatgcgccag ggcaaaggcc cctcctcctt     5160

cgtgggacgt gatgtggaag tgtctaacta ggctcaaacc tacactgact ggtcccaccc     5220

ccctcctgta ccgcttgggt gccgtgacca atgaggtcac cttgacgcac cccgtgacga     5280

aatacatcgc cacgtgcatg caagctgacc tcgagatcat gacaagctca tgggtcctgg     5340

cggggggggt gctagccgcc gtggcatctt actgcctggc gactggctgc atttccatca     5400

ttggccgcct acacctgaat gatcgggtgg ttgtggcccc cgacaaggaa atcttatatg     5460

aggcctttga tgagatggaa gaatgcgcct ccaaagccgc cctcattgag gaagggcagc     5520

ggatggcgga gatgctcaaa tctaagatac aaggcctcct acaacaggcc acaaggcaag     5580

ctcaagacat acagccagct atacagtcat catggcccaa gcttgaacaa ttttgggcca     5640

aacacatgtg gaacttcatc agtggtatac agtacctagc aggactctcc accctaccgg     5700

gaaatcctgc agtagcatca atgatggctt ttagcgccgc gctgactagc ccactaccca     5760

ccagcaccac catcctcttg aacatcatgg gaggatggtt ggcctctcag attgcccccc     5820

ctgccggagc cactggcttc gttgtcagtg gtctagtggg ggcggccgtc ggaagcatag     5880

gcctgggtaa gatactggtg gacgttttgg ccgggtacgg cgcaggcatt tcaggggccc     5940

tcgtagcttt taagatcatg agcggcgaga agcccacggt agaagacgtt gtgaatctcc     6000

tgcctgctat tctgtctcct ggtgcgttgg tagtgggagt catctgtgca gcaatcctgc     6060

gccgccacgt cggtcaggga gagggggcgg tccagtggat gaacagactg atcgccttcg     6120

cctccagggg aaaccacgtt gcccctaccc actacgtggt ggagtctgac gcttcacagc     6180

gtgtaacgca ggtgctgagt tcacttacaa ttaccagctt acttaggaga ctacatgcct     6240

ggatcactga agattgccca gtcccatgct cggggtcttg gctccaggac atttgggatt     6300

gggtttgttc catcctcaca gacttcaaaa actggctgtc ttcaaaatta ctccccaaga     6360

tgcccggcat tccctttatc tcttgccaga agggatacaa gggtgtatgg gctggtacgg     6420

gtgtcatgac tactcggtgc ccatgtggag caaacatctc gggccatgtc cgcatgggca     6480

ccatgaaaat aacaggcccg aagacttgct tgaacctgtg gcaggggact ttccccatta     6540

attgttacac agaagggcct tgcgtgccaa aaccccctcc taattacaag accgcaattt     6600

ggagggtggc agcgtcggag tacgttgagg tcacacagca tggctctttc tcgtatgtaa     6660

cagggttaac cagtgacaac cttaaggtcc cttgccaggt accagctcca gaatttttct     6720

cttgggtgga cggggtgcaa atccaccgat tcgcccccgt tccaggtccc ttctttcggg     6780

atgaggtaac gttcaccgta ggccttaact ccttcgtggt cggctctcag ctcccttgcg     6840

atcctgagcc ggacaccgag gtactggcct ccatgttgac agacccgtcc cacatcaccg     6900

cggaggcggc agccaggcga ttggcaaggg gatctccccc ttcacaggct agctcctcag     6960

cgagccagct ctctgccccg tccttgaagg ctacctgtac cacccataag acagcatatg     7020

attgtgacat ggtggatgcc aaccttttca tgggaggcga tgtgacccgg attgagtctg     7080

actctaaggt gatcgttctc gactccctcg attccatgac tgaggtagtg gatgatcgtg     7140

agccttctgt accatcagag tacctgatca agaggagaaa gttcccaccg gcgctgcctc     7200

cttgggcccg tccagactac aatcctgttt tgatcgagac atggaagagg ccgggctatg     7260

aaccacccac tgtcctaggc tgtgccctcc cccccacacc tcaaacgcca gtgcctccac     7320

ctcggaggcg ccgcgccaaa gtcctgaccc aggacaatgt ggaggggatc ctcagggaga     7380

tggctgacaa agtactcagc cctctccaag acaacaatga ctccggtcac tccactggag     7440

cggataccgg aggagacatc gtccagcaac cctctgacga gactgccgct tcagaagcgg     7500

ggtcactgtc ctccatgcct ccccttgagg gagagccggg agaccctgac ctggagtttg     7560

aaccagtggg atccgctccc ccttctgagg gggagtgtga ggtcattgat tcggactcta     7620

agtcgtggtc cacagtctct gatcaagagg attctgttat ctgctgctct atgtcatact     7680

cctggacggg ggccctcata acaccatgtg ggcccgaaga ggagaagtta ccgatcaacc     7740

ctctgagtaa ttcgctcatg cggttccata ataaggtgta ctccacaacc tcgaggagtg     7800

cctctctgag ggcaaagaag gtgacttttg acagggtgca ggtgctggac gcacactatg     7860

actcagtctt gcaggacgtt aagcgggccg cctctaaggt tagtgcgagg ctcctcacgg     7920

tagaggaagc ctgcgcgctg accccgcccc actccgccaa atcgcgatac ggatttgggg     7980

caaaagaggt gcgcagctta tccaggaggg ccgttaacca catccggtcc gtgtgggagg     8040

acctcctgga agaccaacat accccaattg acacaactat catggctaaa aatgaggtgt     8100

tctgcattga tccaactaaa ggtgggaaaa agccagctcg cctcatcgta taccccgacc     8160

ttggggtcag ggtgtgcgaa aagatggccc tctatgacat cgcacaaaag cttcccaaag     8220

cgataatggg gccatcctat gggttccaat actctcccgc agaacgggtc gatttcctcc     8280

tcaaagcttg gggaagtaag aaggacccaa tggggttctc gtatgacacc cgctgctttg     8340

actcaaccgt cacggagagg gacataagaa cagaagaatc catatatcag gcttgttctc     8400

tgcctcaaga agccagaact gtcatacact cgctcactga gagactttac gtaggagggc     8460

ccatgacaaa cagcaaaggg caatcctgcg gctacaggcg ttgccgcgca agcggtgttt     8520

tcaccaccag catggggaat accatgacat gttacatcaa agcccttgca gcgtgtaagg     8580

ctgcagggat cgtggaccct gttatgttgg tgtgtggaga cgacctggtc gtcatctcag     8640

agagccaagg taacgaggag gacgagcgaa acctgagagc tttcacggag gctatgacca     8700

ggtattccgc ccctcccggt gaccttccca gaccggaata tgacttggag cttataacat     8760

cctgctcctc aaacgtatcg gtagcgctgg actctcgggg tcgccgccgg tacttcctaa     8820

ccagagaccc taccactcca atcacccgag ctgcttggga aacagtaaga cactcccctg     8880

tcaattcttg gctgggcaac atcatccagt acgcccccac aatctgggtc cggatggtca     8940

taatgactca cttcttctcc atactattgg cccaggacac tctgaaccaa aatctcaatt     9000

ttgagatgta cggggcagta tactcggtca atccattaga cctaccggcc ataattgaaa     9060

ggctacatgg gcttgaagcc ttttcactgc acacatactc tccccgcgaa ctctcacggg     9120

tggcagcaac tctcagaaaa cttggagcgc ctccccttag agcgtggaag agtcgggcgc     9180

gtgccgtgag agcttcactc atcgcccaag gagcgagggc ggccatttgt ggccgctacc     9240

tcttcaactg ggcggtgaaa acaaagctca aactcactcc attgcccgag gcgagccgcc     9300

tggatttatc cgggtggttc accgtgggcg ccggcggggg cggcatttat cacagcgtgt     9360

cgcatgcccg accccgccta ttactccttt gcctactcct acttagcgta ggagtaggca     9420

tctttttact ccccgctcgg tagagcggca aaccctagct acactccata gctagtttcc     9480

gttttttttt ttttgttttt tttttttttt tttttttttt tttttttttt tttcttttcc     9540

tttttttttt ttctctttct tggtggctcc atcttagccc tagtcacggc tagctgtgaa     9600

aggtccgtga gccgcatgac tgcagagagt gccgtaactg gtctctctgc agatcatgt      9659


<210>  56
<211>  9659
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  56
gcccgccccc tgatgggggc gacactccgc catgaatcac tcccctgtga ggaactactg       60

tcttcacgca gaaagcgtct agccatggcg ttagtatgag tgtcgtacag cctccaggcc      120

cccccctccc gggagagcca tagtggtctg cggaaccggt gagtacaccg gaattaccgg      180

aaagactggg tcctttcttg gataaaccca ctctatgtcc ggtcatttgg gcacgccccc      240

gcaagactgc tagccgagta gcgttgggtt gcgaaaggcc ttgtggtact gcctgatagg      300

gtgcttgcga gtgccccggg aggtctcgta gaccgtgcat catgagcaca aatcctaaac      360

ctcaaagaaa aaccaaaaga aacacaaacc gccgcccaca ggacgttaag ttcccgggtg      420

gcggtcagat cgttggcgga gtttacttgc tgccgcgcag gggccccagg ttgggtgtgc      480

gcgcgacaag gaagacttct gagcgatccc agccgcgtgg acgacgccag cccatcccga      540

aagatcggcg ctccaccggc aagtcctggg gaaagccagg atatccttgg cccctgtacg      600

gaaacgaggg ttgcggctgg gcgggttggc tcctgtcccc ccgcgggtct cgtcctactt      660

ggggccccac cgacccccgg catagatcac gcaatttggg cagagtcatc gataccatta      720

cgtgtggttt tgccgacctc atggggtaca tccctgtcgt tggcgccccg gttggaggcg      780

tcgccagagc tctggcacac ggtgttaggg tcctggagga cgggataaat tacgcaacag      840

ggaatttacc cggttgctct ttttctatct ttttgcttgc tcttctgtca tgcgtcacag      900

tgccagtgtc tgcagtggaa gtcaggaaca ttagttctag ctactacgcc actaatgatt      960

gctcaaacaa cagcatcacc tggcagctca ctgacgcagt tctccatctt cctggatgcg     1020

tcccatgtga gaatgataat ggcaccttgc attgctggat acaagtaaca cccaacgtgg     1080

ctgtgaaaca ccgcggtgcg ctcactcgta gcctgcgaac acacgtcgac atgatcgtaa     1140

tggcagctac ggcctgctcg gccttgtatg tgggagatgt gtgcggggcc gtgatgattc     1200

tatcgcaggc tttcatggta tcaccacaac gccacaactt cacccaagag tgcaactgtt     1260

ccatctacca aggtcacatc accggccatc gcatggcatg ggacatgatg ctgaactggt     1320

ctccaactct tgccatgatc ctcgcctacg ccgctcgtgt tcccgagatg gtcctcgaaa     1380

ttattttcgg cggccattgg ggtgtggtgt ttggcttggc ctacttctcc atgcaaggag     1440

cgtgggccaa agtcattgcc atcctccttc ttgttgcggg agtggatgca accacctatt     1500

ccagcggcca ggaagcgggt cgtaccgtct tggggttcac taacctcttt acttctggtg     1560

ccaagcagaa cctctattta atcaacacca atggcagctg gcacataaac cggactgccc     1620

tcaattgcaa tgacagctta cagacgggtt tcatggcttc cctgttttac acccacaggt     1680

tcaacagctc tggctgcccc gagcgcttgt cttcctgccg cgggctggac gattttcgca     1740

tcggctgggg aaccttggaa tacgaaaccc acgtcaccaa cgatgaggac atgaggccgt     1800

actgctggca ttaccctccg aggccttgcg gcatcgtccc ggctagaacg gtttgcggac     1860

cggtctattg tttcacccct agccctgttg tcgtgggcac cactgacaag cagggcgtac     1920

ccacctacac ctggggggaa aacgagaccg atgtcttcct gctgaatagc acaagacccc     1980

cgcgaggagc ttggttcggc tgcacttgga tgaacgggac tgggttcact aagacatgcg     2040

gtgcaccacc ttgccgcatt aggaaagact acaacagcac tatcgattta ttgtgcccca     2100

cagactgttt taggaagcac cccgatgcta cctatcttaa gtgtggagca gggccttggt     2160

taactcccag gtgcctggta gactaccctt atagactgtg gcattatccg tgcactgtaa     2220

acttcaccat ctttaaggcg cggatgtatg taggaggggt ggagcatcga ttctccgcag     2280

catgcaactt cacgcgcgga gatcgctgca gactggaaga tagggatagg ggtcagcaga     2340

gtccactgct gcattccact actgagtggg cggtgctccc atgctccttc tctgacctac     2400

cagcactatc cactggccta ttgcacctcc accaaaacat cgtggacgtg cagtaccttt     2460

acggactttc tccggctctg acaagataca tcgtgaagtg ggagtgggtg atcctccttt     2520

tcttgttgtt ggcagacgcc aggatctgtg catgcctttg gatgctcatc atactgggcc     2580

aagccgaagc ggcgcttgag aagctcatca tcttgcactc cgctagtgct gctagtgcca     2640

atggtccgct gtggtgtttc atcttcttta cagcggcctg gtacttaaag ggcagggtgg     2700

tccccgtggc cacgtactct gttctcggct tatggtcctt cctcctccta gtcctggcct     2760

taccacagca ggcttatgcc ttggacgctg ctgaacaagg ggaactgggg ctggccatat     2820

tagtaattat atccatcttt actcttaccc cagcatacaa gatcctcctg agccgttcag     2880

tgtggtggct gtcctacatg ctggtcttgg ccgaggccca gattcagcaa cgggttcccc     2940

ccctggaggt ccgagggggg cgtgacggaa tcatctgggt ggctgtcatt ctacacccac     3000

gccttgtgtt tgaggtcacg aaatggttgt tagcaatcct ggggcctgcc tacctcctta     3060

aagcgtctct gctacggata ccgtactttg tgagggccca cgctttgcta cgagtgtgta     3120

ccctggtgaa acacctcgcg ggggctaggt acatccagat gctgttgatc accataggca     3180

gatggaccgg cacttacatc tacgaccacc tctccccttt atcaacttgg gcggcccagg     3240

gtttgcggga cctggcaatc gccgtggagc ctgtggtgtt cagcccaatg gagaagaagg     3300

tcattgtgtg gggggctgag acagtggcgt gtggagacat cctgcatggc ctcccggtct     3360

ccgcgaggct aggtagggag gttctgctcg gccctgccga cggctacacc tccaaggggt     3420

ggaagctcct agctcccatt actgcttaca ctcagcaaac tcgtggtctc ctgggtgcta     3480

tcgtggtcag cctaacgggc cgcgacaaaa atgagcaggc tgggcaggtc caggttctgt     3540

cctccgtcac acaaactttc ttggggacat ccatttcggg cgtcctctgg acagtatatc     3600

acggggctgg taataagacc ttggccggcc ccaagggacc agtcactcag atgtacacca     3660

gcgcagaagg ggacctcgtg ggatggccta gtccccccgg gactaagtca ttggacccct     3720

gtacctgcgg ggccgtagac ctctacctgg tcacccgaaa cgctgatgtc attccggtcc     3780

ggaggaaaga tgaccgacgg ggtgcattac tctcgccaag gcccctctca accctcaaag     3840

gatcatccgg agggcccgtg ctctgctcaa ggggacacgc cgtgggcttg ttcagagcgg     3900

ccgtgtgtgc caggggtgta gccaaatcta ttgacttcat ccccgtcgaa tcactcgatg     3960

tcaccacacg gacgcccagt ttctctgaca acagtacgcc gccagctgtg ccccagtctt     4020

accaggtggg ttacttgcac gcaccaacag gcagcggaaa gagcaccaag gtccctgccg     4080

cgtatgccag tcaggggtat aaagtactcg tactaaatcc ctctgtcgcg gccacacttg     4140

gttttggggc ctacatgtcc aaagcccacg ggatcaaccc taatatcaga actggagtgc     4200

ggaccgttac caccggggac tctatcactt actccactta tggcaagttt atcgcagatg     4260

gaggctgtgc agccggtgcc tatgacatca tcatatgcga cgaatgccat tcagtggacg     4320

ctactaccat ccttggcatt ggaacagtcc ttgaccaagc tgagaccgca ggcgtcaggc     4380

tagtggtttt ggccacagcc acgcctcccg gtacggtgac aactccccac agtaacatag     4440

aggaggtggc ccttggtcac gagggcgaga tcccttttta tggcaaagcc attcccctag     4500

ctttcatcaa ggggggcaga cacttgatct tttgccattc aaagaagaag tgcgacgagc     4560

tcgcagcggc cctccggggc atgggtgtca atgccgttgc atactatagg ggtctcgacg     4620

tctccgttat accaactcaa ggagacgtgg tggttgtcgc cactgatgcc ctaatgactg     4680

ggtacaccgg cgactttgac tctgtcatcg actgtaatgt tgcagtctct cagattgttg     4740

acctcagcct agacccaacc ttcaccatca ccactcaaat cgtccctcag gacgctgtct     4800

cccgtagtca acgtagaggg agaactggga gggggcgatt gggcgtttac aggtatgttt     4860

cgtcaggcga aaggccgtct gggatgttcg acagcgtagt gctctgcgag tgctatgatg     4920

ccggggcagc ctggtacgag cttacacctg ctgagactac ggtgagactc cgggcttatt     4980

tcaacacgcc cggtttgccc gtatgtcaag accacctgga gttctgggaa gcggtcttta     5040

caggtctcac acacattgac gcccacttcc tctcccagac gaagcaagga ggagaaaact     5100

ttgcgtatct aacggcctac caggccacag tatgcgccag ggcaaaggcc cctcctcctt     5160

cgtgggacgt gatgtggaag tgtctaacta ggctcaaacc tacactgact ggtcccaccc     5220

ccctcctgta ccgcttgggt gccgtgacca atgaggtcac cttgacgcac cccgtgacga     5280

aatacatcgc cacgtgcatg caagctgacc tcgagatcat gacaagctca tgggtcctgg     5340

cggggggggt gctagccgcc gtggcatctt actgcctggc gactggctgc atttccatca     5400

ttggccgcct acacctgaat gatcgggtgg ttgtggcccc cgacaaggaa atcttatatg     5460

aggcctttga tgagatggaa gaatgcgcct ccaaagccgc cctcattgag gaagggcagc     5520

ggatggcgga gatgctcaaa tctaagatac aaggcctcct acaacaggcc acaaggcaag     5580

ctcaagacat acagccagct atacagtcat catggcccaa gcttgaacaa ttttgggcca     5640

aacacatgtg gaacttcatc agtggtatac agtacctagc aggactctcc accctaccgg     5700

gaaatcctgc agtagcatca atgatggctt ttagcgccgc gctgactagc ccactaccca     5760

ccagcaccac catcctcttg aacatcatgg gaggatggtt ggcctctcag attgcccccc     5820

ctgccggagc cactggcttc gttgtcagtg gtctagtggg ggcggccgtc ggaagcatag     5880

gcctgggtaa gatactggtg gacgttttgg ccgggtacgg cgcaggcatt tcaggggccc     5940

tcgtagcttt taagatcatg agcggcgaga agcccacggt agaagacgtt gtgaatctcc     6000

tgcctgctat tctgtctcct ggtgcgttgg tagtgggagt catctgtgca gcaatcctgc     6060

gccgccacgt cggtcaggga gagggggcgg tccagtggat gaacagactg atcgccttcg     6120

cctccagggg aaaccacgtt gcccctaccc actacgtggt ggagtctgac gcttcacagc     6180

gtgtaacgca ggtgctgagt tcacttacaa ttaccagctt acttaggaga ctacatgcct     6240

gggtcactga agattgccca gtcccatgct cggggtcttg gctccaggac atttgggatt     6300

gggtttgttc catcctcaca gacttcaaaa actggctgtc ttcaaaatta ctccccaaga     6360

tgcccggcat tccctttatc tcttgccaga agggatacaa gggtgtatgg gctggtacgg     6420

gtgtcatgac tactcggtgc ccatgtggag caaacatctc gggccatgtc cgcatgggca     6480

ccatgaaaat aacaggcccg aagacttgct tgaacctgtg gcaggggact ttccccatta     6540

attgttacac agaagggcct tgcgtgccaa aaccccctcc taattacaag accgcaattt     6600

ggagggtggc agcgtcggag tacgttgagg tcacacagca tggctctttc tcgtatgtaa     6660

cagggttaac cagtgacaac cttaaggtcc cttgccaggt accagctcca gaatttttct     6720

cttgggtgga cggggtgcaa atccaccgat tcgcccccgt tccaggtccc ttctttcggg     6780

atgaggtaac gttcaccgta ggccttaact ccttcgtggt cggctctcag ctcccttgcg     6840

atcctgagcc ggacaccgag gtactggcct ccatgttgac agacccgtcc cacatcaccg     6900

cggaggcggc agccaggcga ttggcaaggg gatctccccc ttcacaggct agctcctcag     6960

cgagccagct ctctgccccg tccttgaagg ctacctgtac cacccataag acagcatatg     7020

attgtgacat ggtggatgcc aaccttttca tgggaggcga tgtgacccgg attgagtctg     7080

actctaaggt gatcgttctc gactccctcg attccatgac tgaggtagtg gatgatcgtg     7140

agccttctgt accatcagag tacctgatca agaggagaaa gttcccaccg gcgctgcctc     7200

cttgggcccg tccagactac aatcctgttt tgatcgagac atggaagagg ccgggctatg     7260

aaccacccac tgtcctaggc tgtgccctcc cccccacacc tcaaacgcca gtgcctccac     7320

ctcggaggcg ccgcgccaaa gtcctgaccc aggacaatgt ggaggggatc ctcagggaga     7380

tggctgacaa agtactcagc cctctccaag acaacaatga ctccggtcac tccactggag     7440

cggataccgg aggagacatc gtccagcaac cctctgacga gactgccgct tcagaagcgg     7500

ggtcactgtc ctccatgcct ccccttgagg gagagccggg agaccctgac ctggagtttg     7560

aaccagtggg atccgctccc ccttctgagg gggagtgtga ggtcattgat tcggactcta     7620

agtcgtggtc cacagtctct gatcaagagg attctgttat ctgctgctct atgtcatact     7680

cctggacggg ggccctcata acaccatgtg ggcccgaaga ggagaagtta ccgatcaacc     7740

ctctgagtaa ttcgctcatg cggttccata ataaggtgta ctccacaacc tcgaggagtg     7800

cctctctgag ggcaaagaag gtgacttttg acagggtgca ggtgctggac gcacactatg     7860

actcagtctt gcaggacgtt aagcgggccg cctctaaggt tagtgcgagg ctcctcacgg     7920

tagaggaagc ctgcgcgctg accccgcccc actccgccaa atcgcgatac ggatttgggg     7980

caaaagaggt gcgcagctta tccaggaggg ccgttaacca catccggtcc gtgtgggagg     8040

acctcctgga agaccaacat accccaattg acacaactat catggctaaa aatgaggtgt     8100

tctgcattga tccaactaaa ggtgggaaaa agccagctcg cctcatcgta taccccgacc     8160

ttggggtcag ggtgtgcgaa aagatggccc tctatgacat cgcacaaaag cttcccaaag     8220

cgataatggg gccatcctat gggttccaat actctcccgc agaacgggtc gatttcctcc     8280

tcaaagcttg gggaagtaag aaggacccaa tggggttctc gtatgacacc cgctgctttg     8340

actcaaccgt cacggagagg gacataagaa cagaagaatc catatatcag gcttgttctc     8400

tgcctcaaga agccagaact gtcatacact cgctcactga gagactttac gtaggagggc     8460

ccatgacaaa cagcaaaggg caatcctgcg gctacaggcg ttgccgcgca agcggtgttt     8520

tcaccaccag catggggaat accatgacat gttacatcaa agcccttgca gcgtgtaagg     8580

ctgcagggat cgtggaccct gttatgttgg tgtgtggaga cgacctggtc gtcatctcag     8640

agagccaagg taacgaggag gacgagcgaa acctgagagc tttcacggag gctatgacca     8700

ggtattccgc ccctcccggt gaccttccca gaccggaata tgacttggag cttataacat     8760

cctgctcctc aaacgtatcg gtagcgctgg actctcgggg tcgccgccgg tacttcctaa     8820

ccagagaccc taccactcca atcacccgag ctgcttggga aacagtaaga cactcccctg     8880

tcaattcttg gctgggcaac atcatccagt acgcccccac aatctgggtc cggatggtca     8940

taatgactca cttcttctcc atactattgg cccaggacac tctgaaccaa aatctcaatt     9000

ttgagatgta cggggcagta tactcggtca atccattaga cctaccggcc ataattgaaa     9060

ggctacatgg gcttgaagcc ttttcactgc acacatactc tccccgcgaa ctctcacggg     9120

tggcagcaac tctcagaaaa cttggagcgc ctccccttag agcgtggaag agtcgggcgc     9180

gtgccgtgag agcttcactc atcgcccaag gagcgagggc ggccatttgt ggccgctacc     9240

tcttcaactg ggcggtgaaa acaaagctca aactcactcc attgcccgag gcgagccgcc     9300

tggatttatc cgggtggttc accgtgggcg ccggcggggg cggcatttat cacagcgtgt     9360

cgcatgcccg accccgccta ttactccttt gcctactcct acttagcgta ggagtaggca     9420

tctttttact ccccgctcgg tagagcggca aaccctagct acactccata gctagtttcc     9480

gttttttttt ttttgttttt tttttttttt tttttttttt tttttttttt tttcttttcc     9540

tttttttttt ttctctttct tggtggctcc atcttagccc tagtcacggc tagctgtgaa     9600

aggtccgtga gccgcatgac tgcagagagt gccgtaactg gtctctctgc agatcatgt      9659


<210>  57
<211>  9659
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  57
gcccgccccc tgatgggggc gacactccgc catgaatcac tcccctgtga ggaactactg       60

tcttcacgca gaaagcgtct agccatggcg ttagtatgag tgtcgtacag cctccaggcc      120

cccccctccc gggagagcca tagtggtctg cggaaccggt gagtacaccg gaattaccgg      180

aaagactggg tcctttcttg gataaaccca ctctatgtcc ggtcatttgg gcacgccccc      240

gcaagactgc tagccgagta gcgttgggtt gcgaaaggcc ttgtggtact gcctgatagg      300

gtgcttgcga gtgccccggg aggtctcgta gaccgtgcat catgagcaca aatcctaaac      360

ctcaaagaaa aaccaaaaga aacacaaacc gccgcccaca ggacgttaag ttcccgggtg      420

gcggtcagat cgttggcgga gtttacttgc tgccgcgcag gggccccagg ttgggtgtgc      480

gcgcgacaag gaagacttct gagcgatccc agccgcgtgg acgacgccag cccatcccga      540

aagatcggcg ctccaccggc aagtcctggg gaaagccagg atatccttgg cccctgtacg      600

gaaacgaggg ttgcggctgg gcgggttggc tcctgtcccc ccgcgggtct cgtcctactt      660

ggggccccac cgacccccgg catagatcac gcaatttggg cagagtcatc gataccatta      720

cgtgtggttt tgccgacctc atggggtaca tccctgtcgt tggcgccccg gttggaggcg      780

tcgccagagc tctggcacac ggtgttaggg tcctggagga cgggataaat tacgcaacag      840

ggaatttacc cggttgctct ttttctatct ttttgcttgc tcttctgtca tgcgtcacag      900

tgccagtgtc tgcagtggaa gtcaggaaca ttagttctag ctactacgcc actaatgatt      960

gctcaaacaa cagcatcacc tggcagctca ctgacgcagt tctccatctt cctggatgcg     1020

tcccatgtga gaatgataat ggcaccttgc attgctggat acaagtaaca cccaacgtgg     1080

ctgtgaaaca ccgcggtgcg ctcactcgta gcctgcgaac acacgtcgac atgatcgtaa     1140

tggcagctac ggcctgctcg gccttgtatg tgggagatgt gtgcggggcc gtgatgattc     1200

tatcgcaggc tttcatggta tcaccacaac gccacaactt cacccaagag tgcaactgtt     1260

ccatctacca aggtcacatc accggccatc gcatggcatg ggacatgatg ctgaactggt     1320

ctccaactct tgccatgatc ctcgcctacg ccgctcgtgt tcccgagatg gtcctcgaaa     1380

ttattttcgg cggccattgg ggtgtggtgt ttggcttggc ctacttctcc atgcaaggag     1440

cgtgggccaa agtcattgcc atcctccttc ttgttgcggg agtggatgca accacctatt     1500

ccagcggcca ggaagcgggt cgtaccgtct tggggttcac taacctcttt acttctggtg     1560

ccaagcagaa cctctattta atcaacacca atggcagctg gcacataaac cggactgccc     1620

tcaattgcaa tgacagctta cagacgggtt tcatggcttc cctgttttac acccacaggt     1680

tcaacagctc tggctgcccc gagcgcttgt cttcctgccg cgggctggac gattttcgca     1740

tcggctgggg aaccttggaa tacgaaaccc acgtcaccaa cgatgaggac atgaggccgt     1800

actgctggca ttaccctccg aggccttgcg gcatcgtccc ggctagaacg gtttgcggac     1860

cggtctattg tttcacccct agccctgttg tcgtgggcac cactgacaag cagggcgtac     1920

ccacctacac ctggggggaa aacgagaccg atgtcttcct gctgaatagc acaagacccc     1980

cgcgaggagc ttggttcggc tgcacttgga tgaacgggac tgggttcact aagacatgcg     2040

gtgcaccacc ttgccgcatt aggaaagact acaacagcac tatcgattta ttgtgcccca     2100

cagactgttt taggaagcac cccgatgcta cctatcttaa gtgtggagca gggccttggt     2160

taactcccag gtgcctggta gactaccctt atagactgtg gcattatccg tgcactgtaa     2220

acttcaccat ctttaaggcg cggatgtatg taggaggggt ggagcatcga ttctccgcag     2280

catgcaactt cacgcgcgga gatcgctgca gactggaaga tagggatagg ggtcagcaga     2340

gtccactgct gcattccact actgagtggg cggtgctccc atgctccttc tctgacctac     2400

cagcactatc cactggccta ttgcacctcc accaaaacat cgtggacgtg cagtaccttt     2460

acggactttc tccggctctg acaagataca tcgtgaagtg ggagtgggtg atcctccttt     2520

tcttgttgtt ggcagacgcc aggatctgtg catgcctttg gatgctcatc atactgggcc     2580

aagccgaagc ggcgcttgag aagctcatca tcttgcactc cgctagtgct gctagtgcca     2640

atggtccgct gtggtgtttc atcttcttta cagcggcctg gtacttaaag ggcagggtgg     2700

tccccgtggc cacgtactct gttctcggct tatggtcctt cctcctccta gtcctggcct     2760

taccacagca ggcttatgcc ttggacgctg ctgaacaagg ggaactgggg ctggccatat     2820

tagtaattat atccatcttt actcttaccc cagcatacaa gatcctcctg agccgttcag     2880

tgtggtggct gtcctacatg ctggtcttgg ccgaggccca gattcagcaa tgggttcccc     2940

ccctggaggt ccgagggggg cgtgacggaa tcatctgggt ggctgtcatt ctacacccac     3000

gccttgtgtt tgaggtcacg aaatggttgt tagcaatcct ggggcctgcc tacctcctta     3060

aagcgtctct gctacggata ccgtactttg tgagggccca cgctttgcta cgagtgtgta     3120

ccctggtgaa acacctcgcg ggggctaggt acatccagat gctgttgatc accataggca     3180

gatggaccgg cacttacatc tacgaccacc tctccccttt atcaacttgg gcggcccagg     3240

gtttgcggga cctggcaatc gccgtggagc ctgtggtgtt cagcccaatg gagaagaagg     3300

tcattgtgtg gggggctgag acagtggcgt gtggagacat cctgcatggc ctcccggtct     3360

ccgcgaggct aggtagggag gttctgctcg gccctgccga cggctacacc tccaaggggt     3420

ggaagctcct agctcccatt actgcttaca ctcagcaaac tcgtggtctc ctgggtgcta     3480

tcgtggtcag cctaacgggc cgcgacaaaa atgagcaggc tgggcaggtc caggttctgt     3540

cctccgtcac acaaactttc ttggggacat ccatttcggg cgtcctctgg acagtatatc     3600

acggggctgg taataagacc ttggccggcc ccaagggacc agtcactcag atgtacacca     3660

gcgcagaagg ggacctcgtg ggatggccta gtccccccgg gactaagtca ttggacccct     3720

gtacctgcgg ggccgtagac ctctacctgg tcacccgaaa cgctgatgtc attccggtcc     3780

ggaggaaaga tgaccgacgg ggtgcattac tctcgccaag gcccctctca accctcaaag     3840

gatcatccgg agggcccgtg ctctgctcaa ggggacacgc cgtgggcttg ttcagagcgg     3900

ccgtgtgtgc caggggtgta gccaaatcta ttgacttcat ccccgtcgaa tcactcgatg     3960

tcgccacacg gacgcccagt ttctctgaca acagtacgcc gccagctgtg ccccagtctt     4020

accaggtggg ttacttgcac gcaccaacag gcagcggaaa gagcaccaag gtccctgccg     4080

cgtatgccag tcaggggtat aaagtactcg tactaaatcc ctctgtcgcg gccacacttg     4140

gttttggggc ctacatgtcc aaagcccacg ggatcaaccc taatatcaga actggagtgc     4200

ggaccgttac caccggggac tctatcactt actccactta tggcaagttt atcgcagatg     4260

gaggctgtgc agccggtgcc tatgacatca tcatatgcga cgaatgccat tcagtggacg     4320

ctactaccat ccttggcatt ggaacagtcc ttgaccaagc tgagaccgca ggcgtcaggc     4380

tagtggtttt ggccacagcc acgcctcccg gtacggtgac aactccccac agtaacatag     4440

aggaggtggc ccttggtcac gagggcgaga tcccttttta tggcaaagcc attcccctag     4500

ctttcatcaa ggggggcaga cacttgatct tttgccattc aaagaagaag tgcgacgagc     4560

tcgcagcggc cctccggggc atgggtgtca atgccgttgc atactatagg ggtctcgacg     4620

tctccgttat accaactcaa ggagacgtgg tggttgtcgc cactgatgcc ctaatgactg     4680

ggtacaccgg cgactttgac tctgtcatcg actgtaatgt tgcagtctct cagattgttg     4740

acctcagcct agacccaacc ttcaccatca ccactcaaat cgtccctcag gacgctgtct     4800

cccgtagtca acgtagaggg agaactggga gggggcgatt gggcgtttac aggtatgttt     4860

cgtcaggcga aaggccgtct gggatgttcg acagcgtagt gctctgcgag tgctatgatg     4920

ccggggcagc ctggtacgag cttacacctg ctgagactac ggtgagactc cgggcttatt     4980

tcaacacgcc cggtttgccc gtatgtcaag accacctgga gttctgggaa gcggtcttta     5040

caggtctcac acacattgac gcccacttcc tctcccagac gaagcaagga ggagaaaact     5100

ttgcgtatct aacggcctac caggccacag tatgcgccag ggcaaaggcc cctcctcctt     5160

cgtgggacgt gatgtggaag tgtctaacta ggctcaaacc tacactgact ggtcccaccc     5220

ccctcctgta ccgcttgggt gccgtgacca atgaggtcac cttgacgcac cccgtgacga     5280

aatacatcgc cacgtgcatg caagctgacc tcgagatcat gacaagctca tgggtcctgg     5340

cggggggggt gctagccgcc gtggcatctt actgcctggc gactggctgc atttccatca     5400

ttggccgcct acacctgaat gatcgggtgg ttgtggcccc cgacaaggaa atcttatatg     5460

aggcctttga tgagatggaa gaatgcgcct ccaaagccgc cctcattgag gaagggcagc     5520

ggatggcgga gatgctcaaa tctaagatac aaggcctcct acaacaggcc acaaggcaag     5580

ctcaagacat acagccagct atacagtcat catggcccaa gcttgaacaa ttttgggcca     5640

aacacatgtg gaacttcatc agtggtatac agtacctagc aggactctcc accctaccgg     5700

gaaatcctgc agtagcatca atgatggctt ttagcgccgc gctgactagc ccactaccca     5760

ccagcaccac catcctcttg aacatcatgg gaggatggtt ggcctctcag attgcccccc     5820

ctgccggagc cactggcttc gttgtcagtg gtctagtggg ggcggccgtc ggaagcatag     5880

gcctgggtaa gatactggtg gacgttttgg ccgggtacgg cgcaggcatt tcaggggccc     5940

tcgtagcttt taagatcatg agcggcgaga agcccacggt agaagacgtt gtgaatctcc     6000

tgcctgctat tctgtctcct ggtgcgttgg tagtgggagt catctgtgca gcaatcctgc     6060

gccgccacgt cggtcaggga gagggggcgg tccagtggat gaacagactg atcgccttcg     6120

cctccagggg aaaccacgtt gcccctaccc actacgtggt ggagtctgac gcttcacagc     6180

gtgtaacgca ggtgctgagt tcacttacaa ttaccagctt acttaggaga ctacatgcct     6240

ggatcactga agattgccca gtcccatgct cggggtcttg gctccaggac atttgggatt     6300

gggtttgttc catcctcaca gacttcaaaa actggctgtc ttcaaaatta ctccccaaga     6360

tgcccggcat tccctttatc tcttgccaga agggatacaa gggtgtatgg gctggtacgg     6420

gtgtcatgac tactcggtgc ccatgtggag caaacatctc gggccatgtc cgcatgggca     6480

ccatgaaaat aacaggcccg aagacttgct tgaacctgtg gcaggggact ttccccatta     6540

attgttacac agaagggcct tgcgtgccaa aaccccctcc taattacaag accgcaattt     6600

ggagggtggc agcgtcggag tacgttgagg tcacacagca tggctctttc tcgtatgtaa     6660

cagggttaac cagtgacaac cttaaggtcc cttgccaggt accagctcca gaatttttct     6720

cttgggtgga cggggtgcaa atccaccgat tcgcccccgt tccaggtccc ttctttcggg     6780

atgaggtaac gttcaccgta ggccttaact ccttcgtggt cggctctcag ctcccttgcg     6840

atcctgagcc ggacaccgag gtactggcct ccatgttgac agacccgtcc cacatcaccg     6900

cggaggcggc agccaggcga ttggcaaggg gatctccccc ttcacaggct agctcctcag     6960

cgagccagct ctctgccccg tccttgaagg ctacctgtac cacccataag acagcatatg     7020

attgtgacat ggtggatgcc aaccttttca tgggaggcga tgtgacccgg attgagtctg     7080

actctaaggt gatcgttctc gactccctcg attccatgac tgaggtagtg gatgatcgtg     7140

agccttctgt accatcagag tacctgatca agaggagaaa gttcccaccg gcgctgcctc     7200

cttgggcccg tccagactac aatcctgttt tgatcgagac atggaagagg ccgggctatg     7260

aaccacccac tgtcctaggc tgtgccctcc cccccacacc tcaaacgcca gtgcctccac     7320

ctcggaggcg ccgcgccaaa gtcctgaccc aggacaatgt ggaggggatc ctcagggaga     7380

tggctgacaa agtactcagc cctctccaag acaacaatga ctccggtcac tccactggag     7440

cggataccgg aggagacatc gtccagcaac cctctgacga gactgccgct tcagaagcgg     7500

ggtcactgtc ctccatgcct ccccttgagg gagagccggg agaccctgac ctggagtttg     7560

aaccagtggg atccgctccc ccttctgagg gggagtgtga ggtcattgat tcggactcta     7620

agtcgtggtc cacagtctct gatcaagagg attctgttat ctgctgctct atgtcatact     7680

cctggacggg ggccctcata acaccatgtg ggcccgaaga ggagaagtta ccgatcaacc     7740

ctctgagtaa ttcgctcatg cggttccata ataaggtgta ctccacaacc tcgaggagtg     7800

cctctctgag ggcaaagaag gtgacttttg acagggtgca ggtgctggac gcacactatg     7860

actcagtctt gcaggacgtt aagcgggccg cctctaaggt tagtgcgagg ctcctcacgg     7920

tagaggaagc ctgcgcgctg accccgcccc actccgccaa atcgcgatac ggatttgggg     7980

caaaagaggt gcgcagctta tccaggaggg ccgttaacca catccggtcc gtgtgggagg     8040

acctcctgga agaccaacat accccaattg acacaactat catggctaaa aatgaggtgt     8100

tctgcattga tccaactaaa ggtgggaaaa agccagctcg cctcatcgta taccccgacc     8160

ttggggtcag ggtgtgcgaa aagatggccc tctatgacat cgcacaaaag cttcccaaag     8220

cgataatggg gccatcctat gggttccaat actctcccgc agaacgggtc gatttcctcc     8280

tcaaagcttg gggaagtaag aaggacccaa tggggttctc gtatgacacc cgctgctttg     8340

actcaaccgt cacggagagg gacataagaa cagaagaatc catatatcag gcttgttctc     8400

tgcctcaaga agccagaact gtcatacact cgctcactga gagactttac gtaggagggc     8460

ccatgacaaa cagcaaaggg caatcctgcg gctacaggcg ttgccgcgca agcggtgttt     8520

tcaccaccag catggggaat accatgacat gttacatcaa agcccttgca gcgtgtaagg     8580

ctgcagggat cgtggaccct gttatgttgg tgtgtggaga cgacctggtc gtcatctcag     8640

agagccaagg taacgaggag gacgagcgaa acctgagagc tttcacggag gctatgacca     8700

ggtattccgc ccctcccggt gaccttccca gaccggaata tgacttggag cttataacat     8760

cctgctcctc aaacgtatcg gtagcgctgg actctcgggg tcgccgccgg tacttcctaa     8820

ccagagaccc taccactcca atcacccgag ctgcttggga aacagtaaga cactcccctg     8880

tcaattcttg gctgggcaac atcatccagt acgcccccac aatctgggtc cggatggtca     8940

taatgactca cttcttctcc atactattgg cccaggacac tctgaaccaa aatctcaatt     9000

ttgagatgta cggggcagta tactcggtca atccattaga cctaccggcc ataattgaaa     9060

ggctacatgg gcttgaagcc ttttcactgc acacatactc tccccgcgaa ctctcacggg     9120

tggcagcaac tctcagaaaa cttggagcgc ctccccttag agcgtggaag agtcgggcgc     9180

gtgccgtgag agcttcactc atcgcccaag gagcgagggc ggccatttgt ggccgctacc     9240

tcttcaactg ggcggtgaaa acaaagctca aactcactcc attgcccgag gcgagccgcc     9300

tggatttatc cgggtggttc accgtgggcg ccggcggggg cggcatttat cacagcgtgt     9360

cgcatgcccg accccgccta ttactccttt gcctactcct acttagcgta ggagtaggca     9420

tctttttact ccccgctcgg tagagcggca aaccctagct acactccata gctagtttcc     9480

gttttttttt ttttgttttt tttttttttt tttttttttt tttttttttt tttcttttcc     9540

tttttttttt ttctctttct tggtggctcc atcttagccc tagtcacggc tagctgtgaa     9600

aggtccgtga gccgcatgac tgcagagagt gccgtaactg gtctctctgc agatcatgt      9659


<210>  58
<211>  9659
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  58
gcccgccccc tgatgggggc gacactccgc catgaatcac tcccctgtga ggaactactg       60

tcttcacgca gaaagcgtct agccatggcg ttagtatgag tgtcgtacag cctccaggcc      120

cccccctccc gggagagcca tagtggtctg cggaaccggt gagtacaccg gaattaccgg      180

aaagactggg tcctttcttg gataaaccca ctctatgtcc ggtcatttgg gcacgccccc      240

gcaagactgc tagccgagta gcgttgggtt gcgaaaggcc ttgtggtact gcctgatagg      300

gtgcttgcga gtgccccggg aggtctcgta gaccgtgcat catgagcaca aatcctaaac      360

ctcaaagaaa aaccaaaaga aacacaaacc gccgcccaca ggacgttaag ttcccgggtg      420

gcggtcagat cgttggcgga gtttacttgc tgccgcgcag gggccccagg ttgggtgtgc      480

gcgcgacaag gaagacttct gagcgatccc agccgcgtgg acgacgccag cccatcccga      540

aagatcggcg ctccaccggc aagtcctggg gaaagccagg atatccttgg cccctgtacg      600

gaaacgaggg ttgcggctgg gcgggttggc tcctgtcccc ccgcgggtct cgtcctactt      660

ggggccccac cgacccccgg catagatcac gcaatttggg cagagtcatc gataccatta      720

cgtgtggttt tgccgacctc atggggtaca tccctgtcgt tggcgccccg gttggaggcg      780

tcgccagagc tctggcacac ggtgttaggg tcctggagga cgggataaat tacgcaacag      840

ggaatttacc cggttgctct ttttctatct ttttgcttgc tcttctgtca tgcgtcacag      900

tgccagtgtc tgcagtggaa gtcaggaaca ttagttctag ctactacgcc actaatgatt      960

gctcaaacaa cagcatcacc tggcagctca ctgacgcagt tctccatctt cctggatgcg     1020

tcccatgtga gaatgataat ggcaccttgc attgctggat acaagtaaca cccaacgtgg     1080

ctgtgaaaca ccgcggtgcg ctcactcgta gcctgcgaac acacgtcgac atgatcgtaa     1140

tggcagctac ggcctgctcg gccttgtatg tgggagatgt gtgcggggcc gtgatgattc     1200

tatcgcaggc tttcatggta tcaccacaac gccacaactt cacccaagag tgcaactgtt     1260

ccatctacca aggtcacatc accggccatc gcatggcatg ggacatgatg ctgaactggt     1320

ctccaactct tgccatgatc ctcgcctacg ccgctcgtgt tcccgagatg gtcctcgaaa     1380

ttattttcgg cggccattgg ggtgtggtgt ttggcttggc ctacttctcc atgcaaggag     1440

cgtgggccaa agtcattgcc atcctccttc ttgttgcggg agtggatgca accacctatt     1500

ccagcggcca ggaagcgggt cgtaccgtct tggggttcac taacctcttt acttctggtg     1560

ccaagcagaa cctctattta atcaacacca atggcagctg gcacataaac cggactgccc     1620

tcaattgcaa tgacagctta cagacgggtt tcatggcttc cctgttttac acccacaggt     1680

tcaacagctc tggctgcccc gagcgcttgt cttcctgccg cgggctggac gattttcgca     1740

tcggctgggg aaccttggaa tacgaaaccc acgtcaccaa cgatgaggac atgaggccgt     1800

actgctggca ttaccctccg aggccttgcg gcatcgtccc ggctagaacg gtttgcggac     1860

cggtctattg tttcacccct agccctgttg tcgtgggcac cactgacaag cagggcgtac     1920

ccacctacac ctggggggaa aacgagaccg atgtcttcct gctgaatagc acaagacccc     1980

cgcgaggagc ttggttcggc tgcacttgga tgaacgggac tgggttcact aagacatgcg     2040

gtgcaccacc ttgccgcatt aggaaagact acaacagcac tatcgattta ttgtgcccca     2100

cagactgttt taggaagcac cccgatgcta cctatcttaa gtgtggagca gggccttggt     2160

taactcccag gtgcctggta gactaccctt atagactgtg gcattatccg tgcactgtaa     2220

acttcaccat ctttaaggcg cggatgtatg taggaggggt ggagcatcga ttctccgcag     2280

catgcaactt cacgcgcgga gatcgctgca gactggaaga tagggatagg ggtcagcaga     2340

gtccactgct gcattccact actgagtggg cggtgctccc atgctccttc tctgacctac     2400

cagcactatc cactggccta ttgcacctcc accaaaacat cgtggacgtg cagtaccttt     2460

acggactttc tccggctctg acaagataca tcgtgaagtg ggagtgggtg atcctccttt     2520

tcttgttgtt ggcagacgcc aggatctgtg catgcctttg gatgctcatc atactgggcc     2580

aagccgaagc ggcgcttgag aagctcatca tcttgcactc cgctagtgct gctagtgcca     2640

atggtccgct gtggtgtttc atcttcttta cagcggcctg gtacttaaag ggcagggtgg     2700

tccccgtggc cacgtactct gttctcggct tatggtcctt cctcctccta gtcctggcct     2760

taccacagca ggcttatgcc ttggacgctg ctgaacaagg ggaactgggg ctggccatat     2820

tagtaattat atccatcttt actcttaccc cagcatacaa gatcctcctg agccgttcag     2880

tgtggtggct gtcctacatg ctggtcttgg ccgaggccca gattcagcaa tgggttcccc     2940

ccctggaggt ccgagggggg cgtgacggaa tcatctgggt ggctgtcatt ctacacccac     3000

gccttgtgtt tgaggtcacg aaatggttgt tagcaatcct ggggcctgcc tacctcctta     3060

aagcgtctct gctacggata ccgtactttg tgagggccca cgctttgcta cgagtgtgta     3120

ccctggtgaa acacctcgcg ggggctaggt acatccagat gctgttgatc accataggca     3180

gatggaccgg cacttacatc tacgaccacc tctccccttt atcaacttgg gcggcccagg     3240

gtttgcggga cctggcaatc gccgtggagc ctgtggtgtt cagcccaatg gagaagaagg     3300

tcattgtgtg gggggctgag acagtggcgt gtggagacat cctgcatggc ctcccggtct     3360

ccgcgaggct aggtagggag gttctgctcg gccctgccga cggctacacc tccaaggggt     3420

ggaagctcct agctcccatt actgcttaca ctcagcaaac tcgtggtctc ctgggtgcta     3480

tcgtggtcag cctaacgggc cgcgacaaaa atgagcaggc tgggcaggtc caggttctgt     3540

cctccgtcac acaaactttc ttggggacat ccatttcggg cgtcctctgg acagtatatc     3600

acggggctgg taataagacc ttggccggcc ccaagggacc agtcactcag atgtacacca     3660

gcgcagaagg ggacctcgtg ggatggccta gtccccccgg gactaagtca ttggacccct     3720

gtacctgcgg ggccgtagac ctctacctgg tcacccgaaa cgctgatgtc attccggtcc     3780

ggaggaaaga tgaccgacgg ggtgcattac tctcgccaag gcccctctca accctcaaag     3840

gatcatccgg agggcccgtg ctctgctcaa ggggacacgc cgtgggcttg ttcagagcgg     3900

ccgtgtgtgc caggggtgta gccaaatcta ttgacttcat ccccgtcgaa tcactcgatg     3960

tcgccacacg gacgcccagt ttctctgaca acagtacgcc gccagctgtg ccccagtctt     4020

accaggtggg ttacttgcac gcaccaacag gcagcggaaa gagcaccaag gtccctgccg     4080

cgtatgccag tcaggggtat aaagtactcg tactaaatcc ctctgtcgcg gccacacttg     4140

gttttggggc ctacatgtcc aaagcccacg ggatcaaccc taatatcaga actggagtgc     4200

ggaccgttac caccggggac tctatcactt actccactta tggcaagttt atcgcagatg     4260

gaggctgtgc agccggtgcc tatgacatca tcatatgcga cgaatgccat tcagtggacg     4320

ctactaccat ccttggcatt ggaacagtcc ttgaccaagc tgagaccgca ggcgtcaggc     4380

tagtggtttt ggccacagcc acgcctcccg gtacggtgac aactccccac agtaacatag     4440

aggaggtggc ccttggtcac gagggcgaga tcccttttta tggcaaagcc attcccctag     4500

ctttcatcaa ggggggcaga cacttgatct tttgccattc aaagaagaag tgcgacgagc     4560

tcgcagcggc cctccggggc atgggtgtca atgccgttgc atactatagg ggtctcgacg     4620

tctccgttat accaactcaa ggagacgtgg tggttgtcgc cactgatgcc ctaatgactg     4680

ggtacaccgg cgactttgac tctgtcatcg actgtaatgt tgcagtctct cagattgttg     4740

acctcagcct agacccaacc ttcaccatca ccactcaaat cgtccctcag gacgctgtct     4800

cccgtagtca acgtagaggg agaactggga gggggcgatt gggcgtttac aggtatgttt     4860

cgtcaggcga aaggccgtct gggatgttcg acagcgtagt gctctgcgag tgctatgatg     4920

ccggggcagc ctggtacgag cttacacctg ctgagactac ggtgagactc cgggcttatt     4980

tcaacacgcc cggtttgccc gtatgtcaag accacctgga gttctgggaa gcggtcttta     5040

caggtctcac acacattgac gcccacttcc tctcccagac gaagcaagga ggagaaaact     5100

ttgcgtatct aacggcctac caggccacag tatgcgccag ggcaaaggcc cctcctcctt     5160

cgtgggacgt gatgtggaag tgtctaacta ggctcaaacc tacactgact ggtcccaccc     5220

ccctcctgta ccgcttgggt gccgtgacca atgaggtcac cttgacgcac cccgtgacga     5280

aatacatcgc cacgtgcatg caagctgacc tcgagatcat gacaagctca tgggtcctgg     5340

cggggggggt gctagccgcc gtggcatctt actgcctggc gactggctgc atttccatca     5400

ttggccgcct acacctgaat gatcgggtgg ttgtggcccc cgacaaggaa atcttatatg     5460

aggcctttga tgagatggaa gaatgcgcct ccaaagccgc cctcattgag gaagggcagc     5520

ggatggcgga gatgctcaaa tctaagatac aaggcctcct acaacaggcc acaaggcaag     5580

ctcaagacat acagccagct atacagtcat catggcccaa gcttgaacaa ttttgggcca     5640

aacacatgtg gaacttcatc agtggtatac agtacctagc aggactctcc accctaccgg     5700

gaaatcctgc agtagcatca atgatggctt ttagcgccgc gctgactagc ccactaccca     5760

ccagcaccac catcctcttg aacatcatgg gaggatggtt ggcctctcag attgcccccc     5820

ctgccggagc cactggcttc gttgtcagtg gtctagtggg ggcggccgtc ggaagcatag     5880

gcctgggtaa gatactggtg gacgttttgg ccgggtacgg cgcaggcatt tcaggggccc     5940

tcgtagcttt taagatcatg agcggcgaga agcccacggt agaagacgtt gtgaatctcc     6000

tgcctgctat tctgtctcct ggtgcgttgg tagtgggagt catctgtgca gcaatcctgc     6060

gccgccacgt cggtcaggga gagggggcgg tccagtggat gaacagactg atcgccttcg     6120

cctccagggg aaaccacgtt gcccctaccc actacgtggt ggagtctgac gcttcacagc     6180

gtgtaacgca ggtgctgagt tcacttacaa ttaccagctt acttaggaga ctacatgcct     6240

gggtcactga agattgccca gtcccatgct cggggtcttg gctccaggac atttgggatt     6300

gggtttgttc catcctcaca gacttcaaaa actggctgtc ttcaaaatta ctccccaaga     6360

tgcccggcat tccctttatc tcttgccaga agggatacaa gggtgtatgg gctggtacgg     6420

gtgtcatgac tactcggtgc ccatgtggag caaacatctc gggccatgtc cgcatgggca     6480

ccatgaaaat aacaggcccg aagacttgct tgaacctgtg gcaggggact ttccccatta     6540

attgttacac agaagggcct tgcgtgccaa aaccccctcc taattacaag accgcaattt     6600

ggagggtggc agcgtcggag tacgttgagg tcacacagca tggctctttc tcgtatgtaa     6660

cagggttaac cagtgacaac cttaaggtcc cttgccaggt accagctcca gaatttttct     6720

cttgggtgga cggggtgcaa atccaccgat tcgcccccgt tccaggtccc ttctttcggg     6780

atgaggtaac gttcaccgta ggccttaact ccttcgtggt cggctctcag ctcccttgcg     6840

atcctgagcc ggacaccgag gtactggcct ccatgttgac agacccgtcc cacatcaccg     6900

cggaggcggc agccaggcga ttggcaaggg gatctccccc ttcacaggct agctcctcag     6960

cgagccagct ctctgccccg tccttgaagg ctacctgtac cacccataag acagcatatg     7020

attgtgacat ggtggatgcc aaccttttca tgggaggcga tgtgacccgg attgagtctg     7080

actctaaggt gatcgttctc gactccctcg attccatgac tgaggtagtg gatgatcgtg     7140

agccttctgt accatcagag tacctgatca agaggagaaa gttcccaccg gcgctgcctc     7200

cttgggcccg tccagactac aatcctgttt tgatcgagac atggaagagg ccgggctatg     7260

aaccacccac tgtcctaggc tgtgccctcc cccccacacc tcaaacgcca gtgcctccac     7320

ctcggaggcg ccgcgccaaa gtcctgaccc aggacaatgt ggaggggatc ctcagggaga     7380

tggctgacaa agtactcagc cctctccaag acaacaatga ctccggtcac tccactggag     7440

cggataccgg aggagacatc gtccagcaac cctctgacga gactgccgct tcagaagcgg     7500

ggtcactgtc ctccatgcct ccccttgagg gagagccggg agaccctgac ctggagtttg     7560

aaccagtggg atccgctccc ccttctgagg gggagtgtga ggtcattgat tcggactcta     7620

agtcgtggtc cacagtctct gatcaagagg attctgttat ctgctgctct atgtcatact     7680

cctggacggg ggccctcata acaccatgtg ggcccgaaga ggagaagtta ccgatcaacc     7740

ctctgagtaa ttcgctcatg cggttccata ataaggtgta ctccacaacc tcgaggagtg     7800

cctctctgag ggcaaagaag gtgacttttg acagggtgca ggtgctggac gcacactatg     7860

actcagtctt gcaggacgtt aagcgggccg cctctaaggt tagtgcgagg ctcctcacgg     7920

tagaggaagc ctgcgcgctg accccgcccc actccgccaa atcgcgatac ggatttgggg     7980

caaaagaggt gcgcagctta tccaggaggg ccgttaacca catccggtcc gtgtgggagg     8040

acctcctgga agaccaacat accccaattg acacaactat catggctaaa aatgaggtgt     8100

tctgcattga tccaactaaa ggtgggaaaa agccagctcg cctcatcgta taccccgacc     8160

ttggggtcag ggtgtgcgaa aagatggccc tctatgacat cgcacaaaag cttcccaaag     8220

cgataatggg gccatcctat gggttccaat actctcccgc agaacgggtc gatttcctcc     8280

tcaaagcttg gggaagtaag aaggacccaa tggggttctc gtatgacacc cgctgctttg     8340

actcaaccgt cacggagagg gacataagaa cagaagaatc catatatcag gcttgttctc     8400

tgcctcaaga agccagaact gtcatacact cgctcactga gagactttac gtaggagggc     8460

ccatgacaaa cagcaaaggg caatcctgcg gctacaggcg ttgccgcgca agcggtgttt     8520

tcaccaccag catggggaat accatgacat gttacatcaa agcccttgca gcgtgtaagg     8580

ctgcagggat cgtggaccct gttatgttgg tgtgtggaga cgacctggtc gtcatctcag     8640

agagccaagg taacgaggag gacgagcgaa acctgagagc tttcacggag gctatgacca     8700

ggtattccgc ccctcccggt gaccttccca gaccggaata tgacttggag cttataacat     8760

cctgctcctc aaacgtatcg gtagcgctgg actctcgggg tcgccgccgg tacttcctaa     8820

ccagagaccc taccactcca atcacccgag ctgcttggga aacagtaaga cactcccctg     8880

tcaattcttg gctgggcaac atcatccagt acgcccccac aatctgggtc cggatggtca     8940

taatgactca cttcttctcc atactattgg cccaggacac tctgaaccaa aatctcaatt     9000

ttgagatgta cggggcagta tactcggtca atccattaga cctaccggcc ataattgaaa     9060

ggctacatgg gcttgaagcc ttttcactgc acacatactc tccccgcgaa ctctcacggg     9120

tggcagcaac tctcagaaaa cttggagcgc ctccccttag agcgtggaag agtcgggcgc     9180

gtgccgtgag agcttcactc atcgcccaag gagcgagggc ggccatttgt ggccgctacc     9240

tcttcaactg ggcggtgaaa acaaagctca aactcactcc attgcccgag gcgagccgcc     9300

tggatttatc cgggtggttc accgtgggcg ccggcggggg cggcatttat cacagcgtgt     9360

cgcatgcccg accccgccta ttactccttt gcctactcct acttagcgta ggagtaggca     9420

tctttttact ccccgctcgg tagagcggca aaccctagct acactccata gctagtttcc     9480

gttttttttt ttttgttttt tttttttttt tttttttttt tttttttttt tttcttttcc     9540

tttttttttt ttctctttct tggtggctcc atcttagccc tagtcacggc tagctgtgaa     9600

aggtccgtga gccgcatgac tgcagagagt gccgtaactg gtctctctgc agatcatgt      9659


<210>  59
<211>  9659
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  59
gcccgccccc tgatgggggc gacactccgc catgaatcac tcccctgtga ggaactactg       60

tcttcacgca gaaagcgtct agccatggcg ttagtatgag tgtcgtacag cctccaggcc      120

cccccctccc gggagagcca tagtggtctg cggaaccggt gagtacaccg gaattaccgg      180

aaagactggg tcctttcttg gataaaccca ctctatgtcc ggtcatttgg gcacgccccc      240

gcaagactgc tagccgagta gcgttgggtt gcgaaaggcc ttgtggtact gcctgatagg      300

gtgcttgcga gtgccccggg aggtctcgta gaccgtgcat catgagcaca aatcctaaac      360

ctcaaagaaa aaccaaaaga aacacaaacc gccgcccaca ggacgttaag ttcccgggtg      420

gcggtcagat cgttggcgga gtttacttgc tgccgcgcag gggccccagg ttgggtgtgc      480

gcgcgacaag gaagacttct gagcgatccc agccgcgtgg acgacgccag cccatcccga      540

aagatcggcg ctccaccggc aagtcctggg gaaagccagg atatccttgg cccctgtacg      600

gaaacgaggg ttgcggctgg gcgggttggc tcctgtcccc ccgcgggtct cgtcctactt      660

ggggccccac cgacccccgg catagatcac gcaatttggg cagagtcatc gataccatta      720

cgtgtggttt tgccgacctc atggggtaca tccctgtcgt tggcgccccg gttggaggcg      780

tcgccagagc tctggcacac ggtgttaggg tcctggagga cgggataaat tacgcaacag      840

ggaatttacc cggttgctct ttttctatct ttttgcttgc tcttctgtca tgcgtcacag      900

tgccagtgtc tgcagtggaa gtcaggaaca ttagttctag ctactacgcc actaatgatt      960

gctcaaacaa cagcatcacc tggcagctca ctgacgcagt tctccatctt cctggatgcg     1020

tcccatgtga gaatgataat ggcaccttgc attgctggat acaagtaaca cccaacgtgg     1080

ctgtgaaaca ccgcggtgcg ctcactcgta gcctgcgaac acacgtcgac atgatcgtaa     1140

tggcagctac ggcctgctcg gccttgtatg tgggagatgt gtgcggggcc gtgatgattc     1200

tatcgcaggc tttcatggta tcaccacaac gccacaactt cacccaagag tgcaactgtt     1260

ccatctacca aggtcacatc accggccatc gcatggcatg ggacatgatg ctgaactggt     1320

ctccaactct tgccatgatc ctcgcctacg ccgctcgtgt tcccgagatg gtcctcgaaa     1380

ttattttcgg cggccattgg ggtgtggtgt ttggcttggc ctacttctcc atgcaaggag     1440

cgtgggccaa agtcattgcc atcctccttc ttgttgcggg agtggatgca accacctatt     1500

ccagcggcca ggaagcgggt cgtaccgtct tggggttcac taacctcttt acttctggtg     1560

ccaagcagaa cctctattta atcaacacca atggcagctg gcacataaac cggactgccc     1620

tcaattgcaa tgacagctta cagacgggtt tcatggcttc cctgttttac acccacaggt     1680

tcaacagctc tggctgcccc gagcgcttgt cttcctgccg cgggctggac gattttcgca     1740

tcggctgggg aaccttggaa tacgaaaccc acgtcaccaa cgatgaggac atgaggccgt     1800

actgctggca ttaccctccg aggccttgcg gcatcgtccc ggctagaacg gtttgcggac     1860

cggtctattg tttcacccct agccctgttg tcgtgggcac cactgacaag cagggcgtac     1920

ccacctacac ctggggggaa aacgagaccg atgtcttcct gctgaatagc acaagacccc     1980

cgcgaggagc ttggttcggc tgcacttgga tgaacgggac tgggttcact aagacatgcg     2040

gtgcaccacc ttgccgcatt aggaaagact acaacagcac tatcgattta ttgtgcccca     2100

cagactgttt taggaagcac cccgatgcta cctatcttaa gtgtggagca gggccttggt     2160

taactcccag gtgcctggta gactaccctt atagactgtg gcattatccg tgcactgtaa     2220

acttcaccat ctttaaggcg cggatgtatg taggaggggt ggagcatcga ttctccgcag     2280

catgcaactt cacgcgcgga gatcgctgca gactggaaga tagggatagg ggtcagcaga     2340

gtccactgct gcattccact actgagtggg cggtgctccc atgctccttc tctgacctac     2400

cagcactatc cactggccta ttgcacctcc accaaaacat cgtggacgtg cagtaccttt     2460

acggactttc tccggctctg acaagataca tcgtgaagtg ggagtgggtg atcctccttt     2520

tcttgttgtt ggcagacgcc aggatctgtg catgcctttg gatgctcatc atactgggcc     2580

aagccgaagc ggcgcttgag aagctcatca tcttgcactc cgctagtgct gctagtgcca     2640

atggtccgct gtggtttttc atcttcttta cagcggcctg gtacttaaag ggcagggtgg     2700

tccccgtggc cacgtactct gttctcggct tatggtcctt cctcctccta gtcctggcct     2760

taccacagca ggcttatgcc ttggacgctg ctgaacaagg ggaactgggg ctggccatat     2820

tagtaattat atccatcttt actcttaccc cagcatacaa gatcctcctg agccgttcag     2880

tgtggtggct gtcctacatg ctggtcttgg ccgaggccca gattcagcaa tgggttcccc     2940

ccctggaggt ccgagggggg cgtgacggaa tcatctgggt ggctgtcatt ctacacccac     3000

gccttgtgtt tgaggtcacg aaatggttgt tagcaatcct ggggcctgcc tacctcctta     3060

aagcgtctct gctacggata ccgtactttg tgagggccca cgctttgcta cgagtgtgta     3120

ccctggtgaa acacctcgcg ggggctaggt acatccagat gctgttgatc accataggca     3180

gatggaccgg cacttacatc tacgaccacc tctccccttt atcaacttgg gcggcccagg     3240

gtttgcggga cctggcaatc gccgtggagc ctgtggtgtt cagcccaatg gagaagaagg     3300

tcattgtgtg gggggctgag acagtggcgt gtggagacat cctgcatggc ctcccggtct     3360

ccgcgaggct aggtagggag gttctgctcg gccctgccga cggctacacc tccaaggggt     3420

ggaagctcct agctcccatt actgcttaca ctcagcaaac tcgtggtctc ctgggtgcta     3480

tcgtggtcag cctaacgggc cgcgacaaaa atgagcaggc tgggcaggtc caggttctgt     3540

cctccgtcac acaaactttc ttggggacat ccatttcggg cgtcctctgg acagtatatc     3600

acggggctgg taataagacc ttggccggcc ccaagggacc agtcactcag atgtacacca     3660

gcgcagaagg ggacctcgtg ggatggccta gtccccccgg gactaagtca ttggacccct     3720

gtacctgcgg ggccgtagac ctctacctgg tcacccgaaa cgctgatgtc attccggtcc     3780

ggaggaaaga tgaccgacgg ggtgcattac tctcgccaag gcccctctca accctcaaag     3840

gatcatccgg agggcccgtg ctctgctcaa ggggacacgc cgtgggcttg ttcagagcgg     3900

ccgtgtgtgc caggggtgta gccaaatcta ttgacttcat ccccgtcgaa tcactcgatg     3960

tcgccacacg gacgcccagt ttctctgaca acagtacgcc gccagctgtg ccccagtctt     4020

accaggtggg ttacttgcac gcaccaacag gcagcggaaa gagcaccaag gtccctgccg     4080

cgtatgccag tcaggggtat aaagtactcg tactaaatcc ctctgtcgcg gccacacttg     4140

gttttggggc ctacatgtcc aaagcccacg ggatcaaccc taatatcaga actggagtgc     4200

ggaccgttac caccggggac tctatcactt actccactta tggcaagttt atcgcagatg     4260

gaggctgtgc agccggtgcc tatgacatca tcatatgcga cgaatgccat tcagtggacg     4320

ctactaccat ccttggcatt ggaacagtcc ttgaccaagc tgagaccgca ggcgtcaggc     4380

tagtggtttt ggccacagcc acgcctcccg gtacggtgac aactccccac agtaacatag     4440

aggaggtggc ccttggtcac gagggcgaga tcccttttta tggcaaagcc attcccctag     4500

ctttcatcaa ggggggcaga cacttgatct tttgccattc aaagaagaag tgcgacgagc     4560

tcgcagcggc cctccggggc atgggtgtca atgccgttgc atactatagg ggtctcgacg     4620

tctccgttat accaactcaa ggagacgtgg tggttgtcgc cactgatgcc ctaatgactg     4680

ggtacaccgg cgactttgac tctgtcatcg actgtaatgt tgcagtctct cagattgttg     4740

acctcagcct agacccaacc ttcaccatca ccactcaaat cgtccctcag gacgctgtct     4800

cccgtagtca acgtagaggg agaactggga gggggcgatt gggcgtttac aggtatgttt     4860

cgtcaggcga aaggccgtct gggatgttcg acagcgtagt gctctgcgag tgctatgatg     4920

ccggggcagc ctggtacgag cttacacctg ctgagactac ggtgagactc cgggcttatt     4980

tcaacacgcc cggtttgccc gtatgtcaag accacctgga gttctgggaa gcggtcttta     5040

caggtctcac acacattgac gcccacttcc tctcccagac gaagcaagga ggagaaaact     5100

ttgcgtatct aacggcctac caggccacag tatgcgccag ggcaaaggcc cctcctcctt     5160

cgtgggacgt gatgtggaag tgtctaacta ggctcaaacc tacactgact ggtcccaccc     5220

ccctcctgta ccgcttgggt gccgtgacca atgaggtcac cttgacgcac cccgtgacga     5280

aatacatcgc cacgtgcatg caagctgacc tcgagatcat gacaagctca tgggtcctgg     5340

cggggggggt gctagccgcc gtggcatctt actgcctggc gactggctgc atttccatca     5400

ttggccgcct acacctgaat gatcgggtgg ttgtggcccc cgacaaggaa atcttatatg     5460

aggcctttga tgagatggaa gaatgcgcct ccaaagccgc cctcattgag gaagggcagc     5520

ggatggcgga gatgctcaaa tctaagatac aaggcctcct acaacaggcc acaaggcaag     5580

ctcaagacat acagccagct atacagtcat catggcccaa gcttgaacaa ttttgggcca     5640

aacacatgtg gaacttcatc agtggtatac agtacctagc aggactctcc accctaccgg     5700

gaaatcctgc agtagcatca atgatggctt ttagcgccgc gctgactagc ccactaccca     5760

ccagcaccac catcctcttg aacatcatgg gaggatggtt ggcctctcag attgcccccc     5820

ctgccggagc cactggcttc gttgtcagtg gtctagtggg ggcggccgtc ggaagcatag     5880

gcctgggtaa gatactggtg gacgttttgg ccgggtacgg cgcaggcatt tcaggggccc     5940

tcgtagcttt taagatcatg agcggcgaga agcccacggt agaagacgtt gtgaatctcc     6000

tgcctgctat tctgtctcct ggtgcgttgg tagtgggagt catctgtgca gcaatcctgc     6060

gccgccacgt cggtcaggga gagggggcgg tccagtggat gaacagactg atcgccttcg     6120

cctccagggg aaaccacgtt gcccctaccc actacgtggt ggagtctgac gcttcacagc     6180

gtgtaacgca ggtgctgagt tcacttacaa ttaccagctt acttaggaga ctacatgcct     6240

gggtcactga agattgccca gtcccatgct cggggtcttg gctccaggac atttgggatt     6300

gggtttgttc catcctcaca gacttcaaaa actggctgtc ttcaaaatta ctccccaaga     6360

tgcccggcat tccctttatc tcttgccaga agggatacaa gggtgtatgg gctggtacgg     6420

gtgtcatgac tactcggtgc ccatgtggag caaacatctc gggccatgtc cgcatgggca     6480

ccatgaaaat aacaggcccg aagacttgct tgaacctgtg gcaggggact ttccccatta     6540

attgttacac agaagggcct tgcgtgccaa aaccccctcc taattacaag accgcaattt     6600

ggagggtggc agcgtcggag tacgttgagg tcacacagca tggctctttc tcgtatgtaa     6660

cagggttaac cagtgacaac cttaaggtcc cttgccaggt accagctcca gaatttttct     6720

cttgggtgga cggggtgcaa atccaccgat tcgcccccgt tccaggtccc ttctttcggg     6780

atgaggtaac gttcaccgta ggccttaact ccttcgtggt cggctctcag ctcccttgcg     6840

atcctgagcc ggacaccgag gtactggcct ccatgttgac agacccgtcc cacatcaccg     6900

cggaggcggc agccaggcga ttggcaaggg gatctccccc ttcacaggct agctcctcag     6960

cgagccagct ctctgccccg tccttgaagg ctacctgtac cacccataag acagcatatg     7020

attgtgacat ggtggatgcc aaccttttca tgggaggcga tgtgacccgg attgagtctg     7080

actctaaggt gatcgttctc gactccctcg attccatgac tgaggtagtg gatgatcgtg     7140

agccttctgt accatcagag tacctgatca agaggagaaa gttcccaccg gcgctgcctc     7200

cttgggcccg tccagactac aatcctgttt tgatcgagac atggaagagg ccgggctatg     7260

aaccacccac tgtcctaggc tgtgccctcc cccccacacc tcaaacgcca gtgcctccac     7320

ctcggaggcg ccgcgccaaa gtcctgaccc aggacaatgt ggaggggatc ctcagggaga     7380

tggctgacaa agtactcagc cctctccaag acaacaatga ctccggtcac tccactggag     7440

cggataccgg aggagacatc gtccagcaac cctctgacga gactgccgct tcagaagcgg     7500

ggtcactgtc ctccatgcct ccccttgagg gagagccggg agaccctgac ctggagtttg     7560

aaccagtggg atccgctccc ccttctgagg gggagtgtga ggtcattgat tcggactcta     7620

agtcgtggtc cacagtctct gatcaagagg attctgttat ctgctgctct atgtcatact     7680

cctggacggg ggccctcata acaccatgtg ggcccgaaga ggagaagtta ccgatcaacc     7740

ctctgagtaa ttcgctcatg cggttccata ataaggtgta ctccacaacc tcgaggagtg     7800

cctctctgag ggcaaagaag gtgacttttg acagggtgca ggtgctggac gcacactatg     7860

actcagtctt gcaggacgtt aagcgggccg cctctaaggt tagtgcgagg ctcctcacgg     7920

tagaggaagc ctgcgcgctg accccgcccc actccgccaa atcgcgatac ggatttgggg     7980

caaaagaggt gcgcagctta tccaggaggg ccgttaacca catccggtcc gtgtgggagg     8040

acctcctgga agaccaacat accccaattg acacaactat catggctaaa aatgaggtgt     8100

tctgcattga tccaactaaa ggtgggaaaa agccagctcg cctcatcgta taccccgacc     8160

ttggggtcag ggtgtgcgaa aagatggccc tctatgacat cgcacaaaag cttcccaaag     8220

cgataatggg gccatcctat gggttccaat actctcccgc agaacgggtc gatttcctcc     8280

tcaaagcttg gggaagtaag aaggacccaa tggggttctc gtatgacacc cgctgctttg     8340

actcaaccgt cacggagagg gacataagaa cagaagaatc catatatcag gcttgttctc     8400

tgcctcaaga agccagaact gtcatacact cgctcactga gagactttac gtaggagggc     8460

ccatgacaaa cagcaaaggg caatcctgcg gctacaggcg ttgccgcgca agcggtgttt     8520

tcaccaccag catggggaat accatgacat gttacatcaa agcccttgca gcgtgtaagg     8580

ctgcagggat cgtggaccct gttatgttgg tgtgtggaga cgacctggtc gtcatctcag     8640

agagccaagg taacgaggag gacgagcgaa acctgagagc tttcacggag gctatgacca     8700

ggtattccgc ccctcccggt gaccttccca gaccggaata tgacttggag cttataacat     8760

cctgctcctc aaacgtatcg gtagcgctgg actctcgggg tcgccgccgg tacttcctaa     8820

ccagagaccc taccactcca atcacccgag ctgcttggga aacagtaaga cactcccctg     8880

tcaattcttg gctgggcaac atcatccagt acgcccccac aatctgggtc cggatggtca     8940

taatgactca cttcttctcc atactattgg cccaggacac tctgaaccaa aatctcaatt     9000

ttgagatgta cggggcagta tactcggtca atccattaga cctaccggcc ataattgaaa     9060

ggctacatgg gcttgaagcc ttttcactgc acacatactc tccccgcgaa ctctcacggg     9120

tggcagcaac tctcagaaaa cttggagcgc ctccccttag agcgtggaag agtcgggcgc     9180

gtgccgtgag agcttcactc atcgcccaag gagcgagggc ggccatttgt ggccgctacc     9240

tcttcaactg ggcggtgaaa acaaagctca aactcactcc attgcccgag gcgagccgcc     9300

tggatttatc cgggtggttc accgtgggcg ccggcggggg cggcatttat cacagcgtgt     9360

cgcatgcccg accccgccta ttactccttt gcctactcct acttagcgta ggagtaggca     9420

tctttttact ccccgctcgg tagagcggca aaccctagct acactccata gctagtttcc     9480

gttttttttt ttttgttttt tttttttttt tttttttttt tttttttttt tttcttttcc     9540

tttttttttt ttctctttct tggtggctcc atcttagccc tagtcacggc tagctgtgaa     9600

aggtccgtga gccgcatgac tgcagagagt gccgtaactg gtctctctgc agatcatgt      9659


<210>  60
<211>  9659
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  60
gcccgccccc tgatgggggc gacactccgc catgaatcac tcccctgtga ggaactactg       60

tcttcacgca gaaagcgtct agccatggcg ttagtatgag tgtcgtacag cctccaggcc      120

cccccctccc gggagagcca tagtggtctg cggaaccggt gagtacaccg gaattaccgg      180

aaagactggg tcctttcttg gataaaccca ctctatgtcc ggtcatttgg gcacgccccc      240

gcaagactgc tagccgagta gcgttgggtt gcgaaaggcc ttgtggtact gcctgatagg      300

gtgcttgcga gtgccccggg aggtctcgta gaccgtgcat catgagcaca aatcctaaac      360

ctcaaagaaa aaccaaaaga aacacaaacc gccgcccaca ggacgttaag ttcccgggtg      420

gcggtcagat cgttggcgga gtttacttgc tgccgcgcag gggccccagg ttgggtgtgc      480

gcgcgacaag gaagacttct gagcgatccc agccgcgtgg acgacgccag cccatcccga      540

aagatcggcg ctccaccggc aagtcctggg gaaagccagg atatccttgg cccctgtacg      600

gaaacgaggg ttgcggctgg gcgggttggc tcctgtcccc ccgcgggtct cgtcctactt      660

ggggccccac cgacccccgg catagatcac gcaatttggg cagagtcatc gataccatta      720

cgtgtggttt tgccgacctc atggggtaca tccctgtcgt tggcgccccg gttggaggcg      780

tcgccagagc tctggcacac ggtgttaggg tcctggagga cgggataaat tacgcaacag      840

ggaatttacc cggttgctct ttttctatct ttttgcttgc tcttctgtca tgcgtcacag      900

tgccagtgtc tgcagtggaa gtcaggaaca ttagttctag ctactacgcc actaatgatt      960

gctcaaacaa cagcatcacc tggcagctca ctgacgcagt tctccatctt cctggatgcg     1020

tcccatgtga gaatgataat ggcaccttgc attgctggat acaagtaaca cccaacgtgg     1080

ctgtgaaaca ccgcggtgcg ctcactcgta gcctgcgaac acacgtcgac atgatcgtaa     1140

tggcagctac ggcctgctcg gccttgtatg tgggagatgt gtgcggggcc gtgatgattc     1200

tatcgcaggc tttcatggta tcaccacaac gccacaactt cacccaagag tgcaactgtt     1260

ccatctacca aggtcacatc accggccatc gcatggcatg ggacatgatg ctgaactggt     1320

ctccaactct tgccatgatc ctcgcctacg ccgctcgtgt tcccgagatg gtcctcgaaa     1380

ttattttcgg cggccattgg ggtgtggtgt ttggcttggc ctacttctcc atgcaaggag     1440

cgtgggccaa agtcattgcc atcctccttc ttgttgcggg agtggatgca accacctatt     1500

ccagcggcca ggaagcgggt cgtaccgtct tggggttcac taacctcttt acttctggtg     1560

ccaagcagaa cctctattta atcaacacca atggcagctg gcacataaac cggactgccc     1620

tcaattgcaa tgacagctta cagacgggtt tcatggcttc cctgttttac acccacaggt     1680

tcaacagctc tggctgcccc gagcgcttgt cttcctgccg cgggctggac gattttcgca     1740

tcggctgggg aaccttggaa tacgaaaccc acgtcaccaa cgatgaggac atgaggccgt     1800

actgctggca ttaccctccg aggccttgcg gcatcgtccc ggctagaacg gtttgcggac     1860

cggtctattg tttcacccct agccctgttg tcgtgggcac cactgacaag cagggcgtac     1920

ccacctacac ctggggggaa aacgagaccg atgtcttcct gctgaatagc acaagacccc     1980

cgcgaggagc ttggttcggc tgcacttgga tgaacgggac tgggttcact aagacatgcg     2040

gtgcaccacc ttgccgcatt aggaaagact acaacagcac tatcgattta ttgtgcccca     2100

cagactgttt taggaagcac cccgatgcta cctatcttaa gtgtggagca gggccttggt     2160

taactcccag gtgcctggta gactaccctt atagactgtg gcattatccg tgcactgtaa     2220

acttcaccat ctttaaggcg cggatgtatg taggaggggt ggagcatcga ttctccgcag     2280

catgcaactt cacgcgcgga gatcgctgca gactggaaga tagggatagg ggtcagcaga     2340

gtccactgct gcattccact actgagtggg cggtgctccc atgctccttc tctgacctac     2400

cagcactatc cactggccta ttgcacctcc accaaaacat cgtggacgtg cagtaccttt     2460

acggactttc tccggctctg acaagataca tcgtgaagtg ggagtgggtg atcctccttt     2520

tcttgttgtt ggcagacgcc aggatctgtg catgcctttg gatgctcatc atactgggcc     2580

aagccgaagc ggcgcttgag aagctcatca tcttgcactc cgctagtgct gctagtgcca     2640

atggtccgct gtggtgtttc atcttcttta cagcggcctg gtacttaaag ggcagggtgg     2700

tccccgtggc cacgtactct gttctcggct tatggtcctt cctcctccta gtcctggcct     2760

taccacagca ggcttatgcc ttggacgctg ctgaacaagg ggaactgggg ctggccatat     2820

tagtaattat atccatcttt actcttaccc cagcatacaa gatcctcctg agccgttcag     2880

tgtggtggct gtcctacatg ctggtcttgg ccgaggccca gattcagcaa tgggttcccc     2940

ccctggaggt ccgagggggg cgtgacggaa tcatctgggt ggctgtcatt ctacacccac     3000

gccttgtgtt tgaggtcacg aaatggttgt tagcaatcct ggggcctgcc tacctcctta     3060

aagcgtctct gctacggata ccgtactttg tgagggccca cgctttgcta cgagtgtgta     3120

ccctggtgaa acacctcgcg ggggctaggt acatccagat gctgttgatc accataggca     3180

gatggaccgg cacttacatc tacgaccacc tctccccttt atcaacttgg gcggcccagg     3240

gtttgcggga cctggcaatc gccgtggagc ctgtggtgtt cagcccaatg gagaagaagg     3300

tcattgtgtg gggggctgag acagtggcgt gtggagacat cctgcatggc ctcccggtct     3360

ccgcgaggct aggtagggag gttctgctcg gccctgccga cggctacacc tccaaggggt     3420

ggaagctcct agctcccatt actgcttaca ctcagcaaac tcgtggtctc ctgggtgcta     3480

tcgtggtcag cctaacgggc cgcgacaaaa atgagcaggc tgggcaggtc caggttctgt     3540

cctccgtcac acaaactttc ttggggacat ccatttcggg cgtcctctgg acagtatatc     3600

acggggctgg taataagacc ttggccggcc ccaagggacc agtcactcag atgtacacca     3660

gcgcagaagg ggacctcgtg ggatggccta gtccccccgg gactaagtca ttggacccct     3720

gtacctgcgg ggccgtagac ctctacctgg tcacccgaaa cgctgatgtc attccggtcc     3780

ggaggaaaga tgaccgacgg ggtgcattac tctcgccaag gcccctctca accctcaaag     3840

gatcatccgg agggcccgtg ctctgctcaa ggggacacgc cgtgggcttg ttcagagcgg     3900

ccgtgtgtgc caggggtgta gccaaatcta ttgacttcat ccccgtcgaa tcactcgatg     3960

tcaccacacg gacgcccagt ttctctgaca acagtacgcc gccagctgtg ccccagtctt     4020

accaggtggg ttacttgcac gcaccaacag gcagcggaaa gagcaccaag gtccctgccg     4080

cgtatgccag tcaggggtat aaagtactcg tactaaatcc ctctgtcgcg gccacacttg     4140

gttttggggc ctacatgtcc aaagcccacg ggatcaaccc taatatcaga actggagtgc     4200

ggaccgttac caccggggac tctatcactt actccactta tggcaagttt atcgcagatg     4260

gaggctgtgc agccggtgcc tatgacatca tcatatgcga cgaatgccat tcagtggacg     4320

ctactaccat ccttggcatt ggaacagtcc ttgaccaagc tgagaccgca ggcgtcaggc     4380

tagtggtttt ggccacagcc acgcctcccg gtacggtgac aactccccac agtaacatag     4440

aggaggtggc ccttggtcac gagggcgaga tcccttttta tggcaaagcc attcccctag     4500

ctttcatcaa ggggggcaga cacttgatct tttgccattc aaagaagaag tgcgacgagc     4560

tcgcagcggc cctccggggc atgggtgtca atgccgttgc atactatagg ggtctcgacg     4620

tctccgttat accaactcaa ggagacgtgg tggttgtcgc cactgatgcc ctaatgactg     4680

ggtacaccgg cgactttgac tctgtcatcg actgtaatgt tgcagtctct cagattgttg     4740

acctcagcct agacccaacc ttcaccatca ccactcaaat cgtccctcag gacgctgtct     4800

cccgtagtca acgtagaggg agaactggga gggggcgatt gggcgtttac aggtatgttt     4860

cgtcaggcga aaggccgtct gggatgttcg acagcgtagt gctctgcgag tgctatgatg     4920

ccggggcagc ctggtacgag cttacacctg ctgagactac ggtgagactc cgggcttatt     4980

tcaacacgcc cggtttgccc gtatgtcaag accacctgga gttctgggaa gcggtcttta     5040

caggtctcac acacattgac gcccacttcc tctcccagac gaagcaagga ggagaaaact     5100

ttgcgtatct aacggcctac caggccacag tatgcgccag ggcaaaggcc cctcctcctt     5160

cgtgggacgt gatgtggaag tgtctaacta ggctcaaacc tacactgact ggtcccaccc     5220

ccctcctgta ccgcttgggt gccgtgacca atgaggtcac cttgacgcac cccgtgacga     5280

aatacatcgc cacgtgcatg caagctgacc tcgagatcat gacaagctca tgggtcctgg     5340

cggggggggt gctagccgcc gtggcatctt actgcctggc gactggctgc atttccatca     5400

ttggccgcct acacctgaat gatcgggtgg ttgtggcccc cgacaaggaa atcttatatg     5460

aggcctttga tgagatggaa gaatgcgcct ccaaagccgc cctcattgag gaagggcagc     5520

ggatggcgga gatgctcaaa tctaagatac aaggcctcct acaacaggcc acaaggcaag     5580

ctcaagacat acagccagct atacagtcat catggcccaa gcttgaacaa ttttgggcca     5640

aacacatgtg gaacttcatc agtggtatac agtacctagc aggactctcc accctaccgg     5700

gaaatcctgc agtagcatca atgatggctt ttagcgccgc gctgactagc ccactaccca     5760

ccagcaccac catcctcttg aacatcatgg gaggatggtt ggcctctcag attgcccccc     5820

ctgccggagc cactggcttc gttgtcagtg gtctagtggg ggcggccgtc ggaagcatag     5880

gcctgggtaa gatactggtg gacgttttgg ccgggtacgg cgcaggcatt tcaggggccc     5940

tcgtagcttt taagatcatg agcggcgaga agcccacggt agaagacgtt gtgaatctcc     6000

tgcctgctat tctgtctcct ggtgcgttgg tagtgggagt catctgtgca gcaatcctgc     6060

gccgccacgt cggtcaggga gagggggcgg tccagtggat gaacagactg atcgccttcg     6120

cctccagggg aaaccacgtt gcccctaccc actacgtggt ggagtctgac gcttcacagc     6180

gtgtaacgca ggtgctgagt tcacttacaa ttaccagctt acttaggaga ctacatgcct     6240

gggtcactga agattgccca gtcccatgct cggggtcttg gctccaggac atttgggatt     6300

gggtttgttc catcctcaca gacttcaaaa actggctgtc ttcaaaatta ctccccaaga     6360

tgcccggcat tccctttatc tcttgccaga agggatacaa gggtgtatgg gctggtacgg     6420

gtgtcatgac tactcggtgc ccatgtggag caaacatctc gggccatgtc cgcatgggca     6480

ccatgaaaat aacaggcccg aagacttgct tgaacctgtg gcaggggact ttccccatta     6540

attgttacac agaagggcct tgcgtgccaa aaccccctcc taattacaag accgcaattt     6600

ggagggtggc agcgtcggag tacgttgagg tcacacagca tggctctttc tcgtatgtaa     6660

cagggttaac cagtgacaac cttaaggtcc cttgccaggt accagctcca gaatttttct     6720

cttgggtgga cggggtgcaa atccaccgat tcgcccccgt tccaggtccc ttctttcggg     6780

atgaggtaac gttcaccgta ggccttaact ccttcgtggt cggctctcag ctcccttgcg     6840

atcctgagcc ggacaccgag gtactggcct ccatgttgac agacccgtcc cacatcaccg     6900

cggaggcggc agccaggcga ttggcaaggg gatctccccc ttcacaggct agctcctcag     6960

cgagccagct ctctgccccg tccttgaagg ctacctgtac cacccataag acagcatatg     7020

attgtgacat ggtggatgcc aaccttttca tgggaggcga tgtgacccgg attgagtctg     7080

actctaaggt gatcgttctc gactccctcg attccatgac tgaggtagtg gatgatcgtg     7140

agccttctgt accatcagag tacctgatca agaggagaaa gttcccaccg gcgctgcctc     7200

cttgggcccg tccagactac aatcctgttt tgatcgagac atggaagagg ccgggctatg     7260

aaccacccac tgtcctaggc tgtgccctcc cccccacacc tcaaacgcca gtgcctccac     7320

ctcggaggcg ccgcgccaaa gtcctgaccc aggacaatgt ggaggggatc ctcagggaga     7380

tggctgacaa agtactcagc cctctccaag acaacaatga ctccggtcac tccactggag     7440

cggataccgg aggagacatc gtccagcaac cctctgacga gactgccgct tcagaagcgg     7500

ggtcactgtc ctccatgcct ccccttgagg gagagccggg agaccctgac ctggagtttg     7560

aaccagtggg atccgctccc ccttctgagg gggagtgtga ggtcattgat tcggactcta     7620

agtcgtggtc cacagtctct gatcaagagg attctgttat ctgctgctct atgtcatact     7680

cctggacggg ggccctcata acaccatgtg ggcccgaaga ggagaagtta ccgatcaacc     7740

ctctgagtaa ttcgctcatg cggttccata ataaggtgta ctccacaacc tcgaggagtg     7800

cctctctgag ggcaaagaag gtgacttttg acagggtgca ggtgctggac gcacactatg     7860

actcagtctt gcaggacgtt aagcgggccg cctctaaggt tagtgcgagg ctcctcacgg     7920

tagaggaagc ctgcgcgctg accccgcccc actccgccaa atcgcgatac ggatttgggg     7980

caaaagaggt gcgcagctta tccaggaggg ccgttaacca catccggtcc gtgtgggagg     8040

acctcctgga agaccaacat accccaattg acacaactat catggctaaa aatgaggtgt     8100

tctgcattga tccaactaaa ggtgggaaaa agccagctcg cctcatcgta taccccgacc     8160

ttggggtcag ggtgtgcgaa aagatggccc tctatgacat cgcacaaaag cttcccaaag     8220

cgataatggg gccatcctat gggttccaat actctcccgc agaacgggtc gatttcctcc     8280

tcaaagcttg gggaagtaag aaggacccaa tggggttctc gtatgacacc cgctgctttg     8340

actcaaccgt cacggagagg gacataagaa cagaagaatc catatatcag gcttgttctc     8400

tgcctcaaga agccagaact gtcatacact cgctcactga gagactttac gtaggagggc     8460

ccatgacaaa cagcaaaggg caatcctgcg gctacaggcg ttgccgcgca agcggtgttt     8520

tcaccaccag catggggaat accatgacat gttacatcaa agcccttgca gcgtgtaagg     8580

ctgcagggat cgtggaccct gttatgttgg tgtgtggaga cgacctggtc gtcatctcag     8640

agagccaagg taacgaggag gacgagcgaa acctgagagc tttcacggag gctatgacca     8700

ggtattccgc ccctcccggt gaccttccca gaccggaata tgacttggag cttataacat     8760

cctgctcctc aaacgtatcg gtagcgctgg actctcgggg tcgccgccgg tacttcctaa     8820

ccagagaccc taccactcca atcacccgag ctgcttggga aacagtaaga cactcccctg     8880

tcaattcttg gctgggcaac atcatccagt acgcccccac aatctgggtc cggatggtca     8940

taatgactca cttcttctcc atactattgg cccaggacac tctgaaccaa aatctcaatt     9000

ttgagatgta cggggcagta tactcggtca atccattaga cctaccggcc ataattgaaa     9060

ggctacatgg gcttgaagcc ttttcactgc acacatactc tccccgcgaa ctctcacggg     9120

tggcagcaac tctcagaaaa cttggagcgc ctccccttag agcgtggaag agtcgggcgc     9180

gtgccgtgag agcttcactc atcgcccaag gagcgagggc ggccatttgt ggccgctacc     9240

tcttcaactg ggcggtgaaa acaaagctca aactcactcc attgcccgag gcgagccgcc     9300

tggatttatc cgggtggttc accgtgggcg ccggcggggg cggcatttat cacagcgtgt     9360

cgcatgcccg accccgccta ttactccttt gcctactcct acttagcgta ggagtaggca     9420

tctttttact ccccgctcgg tagagcggca aaccctagct acactccata gctagtttcc     9480

gttttttttt ttttgttttt tttttttttt tttttttttt tttttttttt tttcttttcc     9540

tttttttttt ttctctttct tggtggctcc atcttagccc tagtcacggc tagctgtgaa     9600

aggtccgtga gccgcatgac tgcagagagt gccgtaactg gtctctctgc agatcatgt      9659


<210>  61
<211>  9659
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  61
gcccgccccc tgatgggggc gacactccgc catgaatcac tcccctgtga ggaactactg       60

tcttcacgca gaaagcgtct agccatggcg ttagtatgag tgtcgtacag cctccaggcc      120

cccccctccc gggagagcca tagtggtctg cggaaccggt gagtacaccg gaattaccgg      180

aaagactggg tcctttcttg gataaaccca ctctatgtcc ggtcatttgg gcacgccccc      240

gcaagactgc tagccgagta gcgttgggtt gcgaaaggcc ttgtggtact gcctgatagg      300

gtgcttgcga gtgccccggg aggtctcgta gaccgtgcat catgagcaca aatcctaaac      360

ctcaaagaaa aaccaaaaga aacacaaacc gccgcccaca ggacgttaag ttcccgggtg      420

gcggtcagat cgttggcgga gtttacttgc tgccgcgcag gggccccagg ttgggtgtgc      480

gcgcgacaag gaagacttct gagcgatccc agccgcgtgg acgacgccag cccatcccga      540

aagatcggcg ctccaccggc aagtcctggg gaaagccagg atatccttgg cccctgtacg      600

gaaacgaggg ttgcggctgg gcgggttggc tcctgtcccc ccgcgggtct cgtcctactt      660

ggggccccac cgacccccgg catagatcac gcaatttggg cagagtcatc gataccatta      720

cgtgtggttt tgccgacctc atggggtaca tccctgtcgt tggcgccccg gttggaggcg      780

tcgccagagc tctggcacac ggtgttaggg tcctggagga cgggataaat tacgcaacag      840

ggaatttacc cggttgctct ttttctatct ttttgcttgc tcttctgtca tgcgtcacag      900

tgccagtgtc tgcagtggaa gtcaggaaca ttagttctag ctactacgcc actaatgatt      960

gctcaaacaa cagcatcacc tggcagctca ctgacgcagt tctccatctt cctggatgcg     1020

tcccatgtga gaatgataat ggcaccttgc attgctggat acaagtaaca cccaacgtgg     1080

ctgtgaaaca ccgcggtgcg ctcactcgta gcctgcgaac acacgtcgac atgatcgtaa     1140

tggcagctac ggcctgctcg gccttgtatg tgggagatgt gtgcggggcc gtgatgattc     1200

tatcgcaggc tttcatggta tcaccacaac gccacaactt cacccaagag tgcaactgtt     1260

ccatctacca aggtcacatc accggccatc gcatggcatg ggacatgatg ctgaactggt     1320

ctccaactct tgccatgatc ctcgcctacg ccgctcgtgt tcccgagatg gtcctcgaaa     1380

ttattttcgg cggccattgg ggtgtggtgt ttggcttggc ctacttctcc atgcaaggag     1440

cgtgggccaa agtcattgcc atcctccttc ttgttgcggg agtggatgca accacctatt     1500

ccagcggcca ggaagcgggt cgtaccgtct tggggttcac taacctcttt acttctggtg     1560

ccaagcagaa cctctattta atcaacacca atggcagctg gcacataaac cggactgccc     1620

tcaattgcaa tgacagctta cagacgggtt tcatggcttc cctgttttac acccacaggt     1680

tcaacagctc tggctgcccc gagcgcttgt cttcctgccg cgggctggac gattttcgca     1740

tcggctgggg aaccttggaa tacgaaaccc acgtcaccaa cgatgaggac atgaggccgt     1800

actgctggca ttaccctccg aggccttgcg gcatcgtccc ggctagaacg gtttgcggac     1860

cggtctattg tttcacccct agccctgttg tcgtgggcac cactgacaag cagggcgtac     1920

ccacctacac ctggggggaa aacgagaccg atgtcttcct gctgaatagc acaagacccc     1980

cgcgaggagc ttggttcggc tgcacttgga tgaacgggac tgggttcact aagacatgcg     2040

gtgcaccacc ttgccgcatt aggaaagact acaacagcac tatcgattta ttgtgcccca     2100

cagactgttt taggaagcac cccgatgcta cctatcttaa gtgtggagca gggccttggt     2160

taactcccag gtgcctggta gactaccctt atagactgtg gcattatccg tgcactgtaa     2220

acttcaccat ctttaaggcg cggatgtatg taggaggggt ggagcatcga ttctccgcag     2280

catgcaactt cacgcgcgga gatcgctgca gactggaaga tagggatagg ggtcagcaga     2340

gtccactgct gcattccact actgagtggg cggtgctccc atgctccttc tctgacctac     2400

cagcactatc cactggccta ttgcacctcc accaaaacat cgtggacgtg cagtaccttt     2460

acggactttc tccggctctg acaagataca tcgtgaagtg ggagtgggtg atcctccttt     2520

tcttgttgtt ggcagacgcc aggatctgtg catgcctttg gatgctcatc atactgggcc     2580

aagccgaagc ggcgcttgag aagctcatca tcttgcactc cgctagtgct gctagtgcca     2640

atggtccgct gtggtgtttc atcttcttta cagcggcctg gtacttaaag ggcagggtgg     2700

tccccgtggc cacgtactct gttctcggct tatggtcctt cctcctccta gtcctggcct     2760

taccacagca ggcttatgcc ttggacgctg ctgaacaagg ggaactgggg ctggccatat     2820

tagtaattat atccatcttt actcttaccc cagcatacaa gatcctcctg agccgttcag     2880

tgtggtggct gtcctacatg ctggtcttgg ccgaggccca gattcagcaa cgggttcccc     2940

ccctggaggt ccgagggggg cgtgacggaa tcatctgggt ggctgtcatt ctacacccac     3000

gccttgtgtt tgaggtcacg aaatggttgt tagcaatcct ggggcctgcc tacctcctta     3060

aagcgtctct gctacggata ccgtactttg tgagggccca cgctttgcta cgagtgtgta     3120

ccctggtgaa acacctcgcg ggggctaggt acatccagat gctgttgatc accataggca     3180

gatggaccgg cacttacatc tacgaccacc tctccccttt atcaacttgg gcggcccagg     3240

gtttgcggga cctggcaatc gccgtggagc ctgtggtgtt cagcccaatg gagaagaagg     3300

tcattgtgtg gggggctgag acagtggcgt gtggagacat cctgcatggc ctcccggtct     3360

ccgcgaggct aggtagggag gttctgctcg gccctgccga cggctacacc tccaaggggt     3420

ggaagctcct agctcccatt actgcttaca ctcagcaaac tcgtggtctc ctgggtgcta     3480

tcgtggtcag cctaacgggc cgcgacaaaa atgagcaggc tgggcaggtc caggttctgt     3540

cctccgtcac acaaactttc ttggggacat ccatttcggg cgtcctctgg acagtatatc     3600

acggggctgg taataagacc ttggccggcc ccaagggacc agtcactcag atgtacacca     3660

gcgcagaagg ggacctcgtg ggatggccta gtccccccgg gactaagtca ttggacccct     3720

gtacctgcgg ggccgtagac ctctacctgg tcacccgaaa cgctgatgtc attccggtcc     3780

ggaggaaaga tgaccgacgg ggtgcattac tctcgccaag gcccctctca accctcaaag     3840

gatcatccgg agggcccgtg ctctgctcaa ggggacacgc cgtgggcttg ttcagagcgg     3900

ccgtgtgtgc caggggtgta gccaaatcta ttgacttcat ccccgtcgaa tcactcgatg     3960

tcaccacacg gacgcccagt ttctctgaca acagtacgcc gccagctgtg ccccagtctt     4020

accaggtggg ttacttgcac gcaccaacag gcagcggaaa gagcaccaag gtccctgccg     4080

cgtatgccag tcaggggtat aaagtactcg tactaaatcc ctctgtcgcg gccacacttg     4140

gttttggggc ctacatgtcc aaagcccacg ggatcaaccc taatatcaga actggagtgc     4200

ggaccgttac caccggggac tctatcactt actccactta tggcaagttt atcgcagatg     4260

gaggctgtgc agccggtgcc tatgacatca tcatatgcga cgaatgccat tcagtggacg     4320

ctactaccat ccttggcatt ggaacagtcc ttgaccaagc tgagaccgca ggcgtcaggc     4380

tagtggtttt ggccacagcc acgcctcccg gtacggtgac aactccccac agtaacatag     4440

aggaggtggc ccttggtcac gagggcgaga tcccttttta tggcaaagcc attcccctag     4500

ctttcatcaa ggggggcaga cacttgatct tttgccattc aaagaagaag tgcgacgagc     4560

tcgcagcggc cctccggggc atgggtgtca atgccgttgc atactatagg ggtctcgacg     4620

tctccgttat accaactcaa ggagacgtgg tggttgtcgc cactgatgcc ctaatgactg     4680

ggtacaccgg cgactttgac tctgtcatcg actgtaatgt tgcagtctct cagattgttg     4740

acctcagcct agacccaacc ttcaccatca ccactcaaat cgtccctcag gacgctgtct     4800

cccgtagtca acgtagaggg agaactggga gggggcgatt gggcgtttac aggtatgttt     4860

cgtcaggcga aaggccgtct gggatgttcg acagcgtagt gctctgcgag tgctatgatg     4920

ccggggcagc ctggtacgag cttacacctg ctgagactac ggtgagactc cgggcttatt     4980

tcaacacgcc cggtttgccc gtatgtcaag accacctgga gttctgggaa gcggtcttta     5040

caggtctcac acacattgac gcccacttcc tctcccagac gaagcaagga ggagaaaact     5100

ttgcgtatct aacggcctac caggccacag tatgcgccag ggcaaaggcc cctcctcctt     5160

cgtgggacgt gatgtggaag tgtctaacta ggctcaaacc tacactgact ggtcccaccc     5220

ccctcctgta ccgcttgggt gccgtgacca atgaggtcac cttgacgcac cccgtgacga     5280

aatacatcgc cacgtgcatg caagctgacc tcgagatcat gacaagctca tgggtcctgg     5340

cggggggggt gctagccgcc gtggcatctt actgcctggc gactggctgc atttccatca     5400

ttggccgcct acacctgaat gatcgggtgg ttgtggcccc cgacaaggaa atcttatatg     5460

aggcctttga tgagatggaa gaatgcgcct ccaaagccgc cctcattgag gaagggcagc     5520

ggatggcgga gatgctcaaa tctaagatac aaggcctcct acaacaggcc acaaggcaag     5580

ctcaagacat acagccagct atacagtcat catggcccaa gcttgaacaa ttttgggcca     5640

aacacatgtg gaacttcatc agtggtatac agtacctagc aggactctcc accctaccgg     5700

gaaatcctgc agtagcatca atgatggctt ttagcgccgc gctgactagc ccactaccca     5760

ccagcaccac catcctcttg aacatcatgg gaggatggtt ggcctctcag attgcccccc     5820

ctgccggagc cactggcttc gttgtcagtg gtctagtggg ggcggccgtc ggaagcatag     5880

gcctgggtaa gatactggtg gacgttttgg ccgggtacgg cgcaggcatt tcaggggccc     5940

tcgtagcttt taagatcatg agcggcgaga agcccacggt agaagacgtt gtgaatctcc     6000

tgcctgctat tctgtctcct ggtgcgttgg tagtgggagt catctgtgca gcaatcctgc     6060

gccgccacgt cggtcaggga gagggggcgg tccagtggat gaacagactg atcgccttcg     6120

cctccagggg aaaccacgtt gcccctaccc actacgtggt ggagtctgac gcttcacagc     6180

gtgtaacgca ggtgctgagt tcacttacaa ttaccagctt acttaggaga ctacatgcct     6240

gggtcactga agattgccca gtcccatgct cggggtcttg gctccaggac atttgggatt     6300

gggtttgttc catcctcaca gacttcaaaa actggctgtc ttcaaaatta ctccccaaga     6360

tgcccggcat tccctttatc tcttgccaga agggatacaa gggtgtatgg gctggtacgg     6420

gtgtcatgac tactcggtgc ccatgtggag caaacatctc gggccatgtc cgcatgggca     6480

ccatgaaaat aacaggcccg aagacttgct tgaacctgtg gcaggggact ttccccatta     6540

attgttacac agaagggcct tgcgtgccaa aaccccctcc taattacaag accgcaattt     6600

ggagggtggc agcgtcggag tacgttgagg tcacacagca tggctctttc tcgtatgtaa     6660

cagggttaac cagtgacaac cttaaggtcc cttgccaggt accagctcca gaatttttct     6720

cttgggtgga cggggtgcaa atccaccgat tcgcccccgt tccaggtccc ttctttcggg     6780

atgaggtaac gttcaccgta ggccttaact ccttcgtggt cggctctcag ctcccttgcg     6840

atcctgagcc ggacaccgag gtactggcct ccatgttgac agacccgtcc cacatcaccg     6900

cggaggcggc agccaggcga ttggcaaggg gatctccccc ttcacaggct agctcctcag     6960

cgagccagct ctctgccccg tccttgaagg ctacctgtac cacccataag acagcatatg     7020

attgtgacat ggtggatgcc aaccttttca tgggaggcga tgtgacccgg attgagtctg     7080

actctaaggt gatcgttctc gactccctcg attccatgac tgaggtagag gatgatcgtg     7140

agccttctgt accatcagag tacctgatca agaggagaaa gttcccaccg gcgctgcctc     7200

cttgggcccg tccagactac aatcctgttt tgatcgagac atggaagagg ccgggctatg     7260

aaccacccac tgtcctaggc tgtgccctcc cccccacacc tcaaacgcca gtgcctccac     7320

ctcggaggcg ccgcgccaaa gtcctgaccc aggacaatgt ggaggggatc ctcagggaga     7380

tggctgacaa agtactcagc cctctccaag acaacaatga ctccggtcac tccactggag     7440

cggataccgg aggagacatc gtccagcaac cctctgacga gactgccgct tcagaagcgg     7500

ggtcactgtc ctccatgcct ccccttgagg gagagccggg agaccctgac ctggagtttg     7560

aaccagtggg atccgctccc ccttctgagg gggagtgtga ggtcattgat tcggactcta     7620

agtcgtggtc cacagtctct gatcaagagg attctgttat ctgctgctct atgtcatact     7680

cctggacggg ggccctcata acaccatgtg ggcccgaaga ggagaagtta ccgatcaacc     7740

ctctgagtaa ttcgctcatg cggttccata ataaggtgta ctccacaacc tcgaggagtg     7800

cctctctgag ggcaaagaag gtgacttttg acagggtgca ggtgctggac gcacactatg     7860

actcagtctt gcaggacgtt aagcgggccg cctctaaggt tagtgcgagg ctcctcacgg     7920

tagaggaagc ctgcgcgctg accccgcccc actccgccaa atcgcgatac ggatttgggg     7980

caaaagaggt gcgcagctta tccaggaggg ccgttaacca catccggtcc gtgtgggagg     8040

acctcctgga agaccaacat accccaattg acacaactat catggctaaa aatgaggtgt     8100

tctgcattga tccaactaaa ggtgggaaaa agccagctcg cctcatcgta taccccgacc     8160

ttggggtcag ggtgtgcgaa aagatggccc tctatgacat cgcacaaaag cttcccaaag     8220

cgataatggg gccatcctat gggttccaat actctcccgc agaacgggtc gatttcctcc     8280

tcaaagcttg gggaagtaag aaggacccaa tggggttctc gtatgacacc cgctgctttg     8340

actcaaccgt cacggagagg gacataagaa cagaagaatc catatatcag gcttgttctc     8400

tgcctcaaga agccagaact gtcatacact cgctcactga gagactttac gtaggagggc     8460

ccatgacaaa cagcaaaggg caatcctgcg gctacaggcg ttgccgcgca agcggtgttt     8520

tcaccaccag catggggaat accatgacat gttacatcaa agcccttgca gcgtgtaagg     8580

ctgcagggat cgtggaccct gttatgttgg tgtgtggaga cgacctggtc gtcatctcag     8640

agagccaagg taacgaggag gacgagcgaa acctgagagc tttcacggag gctatgacca     8700

ggtattccgc ccctcccggt gaccttccca gaccggaata tgacttggag cttataacat     8760

cctgctcctc aaacgtatcg gtagcgctgg actctcgggg tcgccgccgg tacttcctaa     8820

ccagagaccc taccactcca atcacccgag ctgcttggga aacagtaaga cactcccctg     8880

tcaattcttg gctgggcaac atcatccagt acgcccccac aatctgggtc cggatggtca     8940

taatgactca cttcttctcc atactattgg cccaggacac tctgaaccaa aatctcaatt     9000

ttgagatgta cggggcagta tactcggtca atccattaga cctaccggcc ataattgaaa     9060

ggctacatgg gcttgaagcc ttttcactgc acacatactc tccccgcgaa ctctcacggg     9120

tggcagcaac tctcagaaaa cttggagcgc ctccccttag agcgtggaag agtcgggcgc     9180

gtgccgtgag agcttcactc atcgcccaag gagcgagggc ggccatttgt ggccgctacc     9240

tcttcaactg ggcggtgaaa acaaagctca aactcactcc attgcccgag gcgagccgcc     9300

tggatttatc cgggtggttc accgtgggcg ccggcggggg cggcatttat cacagcgtgt     9360

cgcatgcccg accccgccta ttactccttt gcctactcct acttagcgta ggagtaggca     9420

tctttttact ccccgctcgg tagagcggca aaccctagct acactccata gctagtttcc     9480

gttttttttt ttttgttttt tttttttttt tttttttttt tttttttttt tttcttttcc     9540

tttttttttt ttctctttct tggtggctcc atcttagccc tagtcacggc tagctgtgaa     9600

aggtccgtga gccgcatgac tgcagagagt gccgtaactg gtctctctgc agatcatgt      9659


<210>  62
<211>  9659
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  62
gcccgccccc tgatgggggc gacactccgc catgaatcac tcccctgtga ggaactactg       60

tcttcacgca gaaagcgtct agccatggcg ttagtatgag tgtcgtacag cctccaggcc      120

cccccctccc gggagagcca tagtggtctg cggaaccggt gagtacaccg gaattaccgg      180

aaagactggg tcctttcttg gataaaccca ctctatgtcc ggtcatttgg gcacgccccc      240

gcaagactgc tagccgagta gcgttgggtt gcgaaaggcc ttgtggtact gcctgatagg      300

gtgcttgcga gtgccccggg aggtctcgta gaccgtgcat catgagcaca aatcctaaac      360

ctcaaagaaa aaccaaaaga aacacaaacc gccgcccaca ggacgttaag ttcccgggtg      420

gcggtcagat cgttggcgga gtttacttgc tgccgcgcag gggccccagg ttgggtgtgc      480

gcgcgacaag gaagacttct gagcgatccc agccgcgtgg acgacgccag cccatcccga      540

aagatcggcg ctccaccggc aagtcctggg gaaagccagg atatccttgg cccctgtacg      600

gaaacgaggg ttgcggctgg gcgggttggc tcctgtcccc ccgcgggtct cgtcctactt      660

ggggccccac cgacccccgg catagatcac gcaatttggg cagagtcatc gataccatta      720

cgtgtggttt tgccgacctc atggggtaca tccctgtcgt tggcgccccg gttggaggcg      780

tcgccagagc tctggcacac ggtgttaggg tcctggagga cgggataaat tacgcaacag      840

ggaatttacc cggttgctct ttttctatct ttttgcttgc tcttctgtca tgcgtcacag      900

tgccagtgtc tgcagtggaa gtcaggaaca ttagttctag ctactacgcc actaatgatt      960

gctcaaacaa cagcatcacc tggcagctca ctgacgcagt tctccatctt cctggatgcg     1020

tcccatgtga gaatgataat ggcaccttgc attgctggat acaagtaaca cccaacgtgg     1080

ctgtgaaaca ccgcggtgcg ctcactcgta gcctgcgaac acacgtcgac atgatcgtaa     1140

tggcagctac ggcctgctcg gccttgtatg tgggagatgt gtgcggggcc gtgatgattc     1200

tatcgcaggc tttcatggta tcaccacaac gccacaactt cacccaagag tgcaactgtt     1260

ccatctacca aggtcacatc accggccatc gcatggcatg ggacatgatg ctgaactggt     1320

ctccaactct tgccatgatc ctcgcctacg ccgctcgtgt tcccgagatg gtcctcgaaa     1380

ttattttcgg cggccattgg ggtgtggtgt ttggcttggc ctacttctcc atgcaaggag     1440

cgtgggccaa agtcattgcc atcctccttc ttgttgcggg agtggatgca accacctatt     1500

ccagcggcca ggaagcgggt cgtaccgtct tggggttcac taacctcttt acttctggtg     1560

ccaagcagaa cctctattta atcaacacca atggcagctg gcacataaac cggactgccc     1620

tcaattgcaa tgacagctta cagacgggtt tcatggcttc cctgttttac acccacaggt     1680

tcaacagctc tggctgcccc gagcgcttgt cttcctgccg cgggctggac gattttcgca     1740

tcggctgggg aaccttggaa tacgaaaccc acgtcaccaa cgatgaggac atgaggccgt     1800

actgctggca ttaccctccg aggccttgcg gcatcgtccc ggctagaacg gtttgcggac     1860

cggtctattg tttcacccct agccctgttg tcgtgggcac cactgacaag cagggcgtac     1920

ccacctacac ctggggggaa aacgagaccg atgtcttcct gctgaatagc acaagacccc     1980

cgcgaggagc ttggttcggc tgcacttgga tgaacgggac tgggttcact aagacatgcg     2040

gtgcaccacc ttgccgcatt aggaaagact acaacagcac tatcgattta ttgtgcccca     2100

cagactgttt taggaagcac cccgatgcta cctatcttaa gtgtggagca gggccttggt     2160

taactcccag gtgcctggta gactaccctt atagactgtg gcattatccg tgcactgtaa     2220

acttcaccat ctttaaggcg cggatgtatg taggaggggt ggagcatcga ttctccgcag     2280

catgcaactt cacgcgcgga gatcgctgca gactggaaga tagggatagg ggtcagcaga     2340

gtccactgct gcattccact actgagtggg cggtgctccc atgctccttc tctgacctac     2400

cagcactatc cactggccta ttgcacctcc accaaaacat cgtggacgtg cagtaccttt     2460

acggactttc tccggctctg acaagataca tcgtgaagtg ggagtgggtg atcctccttt     2520

tcttgttgtt ggcagacgcc aggatctgtg catgcctttg gatgctcatc atactgggcc     2580

aagccgaagc ggcgcttgag aagctcatca tcttgcactc cgctagtgct gctagtgcca     2640

atggtccgct gtggtgtttc atcttcttta cagcggcctg gtacttaaag ggcagggtgg     2700

tccccgtggc cacgtactct gttctcggct tatggtcctt cctcctccta gtcctggcct     2760

taccacagca ggcttatgcc ttggacgctg ctgaacaagg ggaactgggg ctggccatat     2820

tagtaattat atccatcttt actcttaccc cagcatacaa gatcctcctg agccgttcag     2880

tgtggtggct gtcctacatg ctggtcttgg ccgaggccca gattcagcaa cgggttcccc     2940

ccctggaggt ccgagggggg cgtgacggaa tcatctgggt ggctgtcatt ctacacccac     3000

gccttgtgtt tgaggtcacg aaatggttgt tagcaatcct ggggcctgcc tacctcctta     3060

aagcgtctct gctacggata ccgtactttg tgagggccca cgctttgcta cgagtgtgta     3120

ccctggtgaa acacctcgcg ggggctaggt acatccagat gctgttgatc accataggca     3180

gatggaccgg cacttacatc tacgaccacc tctccccttt atcaacttgg gcggcccagg     3240

gtttgcggga cctggcaatc gccgtggagc ctgtggtgtt cagcccaatg gagaagaagg     3300

tcattgtgtg gggggctgag acagtggcgt gtggagacat cctgcatggc ctcccggtct     3360

ccgcgaggct aggtagggag gttctgctcg gccctgccga cggctacacc tccaaggggt     3420

ggaagctcct agctcccatt actgcttaca ctcagcaaac tcgtggtctc ctgggtgcta     3480

tcgtggtcag cctaacgggc cgcgacaaaa atgagcaggc tgggcaggtc caggttctgt     3540

cctccgtcac acaaactttc ttggggacat ccatttcggg cgtcctctgg acagtatatc     3600

acggggctgg taataagacc ttggccggcc ccaagggacc agtcactcag atgtacacca     3660

gcgcagaagg ggacctcgtg ggatggccta gtccccccgg gactaagtca ttggacccct     3720

gtacctgcgg ggccgtagac ctctacctgg tcacccgaaa cgctgatgtc attccggtcc     3780

ggaggaaaga tgaccgacgg ggtgcattac tctcgccaag gcccctctca accctcaaag     3840

gatcatccgg agggcccgtg ctctgctcaa ggggacacgc cgtgggcttg ttcagagcgg     3900

ccgtgtgtgc caggggtgta gccaaatcta ttgacttcat ccccgtcgaa tcactcgatg     3960

tcgccacacg gacgcccagt ttctctgaca acagtacgcc gccagctgtg ccccagtctt     4020

accaggtggg ttacttgcac gcaccaacag gcagcggaaa gagcaccaag gtccctgccg     4080

cgtatgccag tcaggggtat aaagtactcg tactaaatcc ctctgtcgcg gccacacttg     4140

gttttggggc ctacatgtcc aaagcccacg ggatcaaccc taatatcaga actggagtgc     4200

ggaccgttac caccggggac tctatcactt actccactta tggcaagttt atcgcagatg     4260

gaggctgtgc agccggtgcc tatgacatca tcatatgcga cgaatgccat tcagtggacg     4320

ctactaccat ccttggcatt ggaacagtcc ttgaccaagc tgagaccgca ggcgtcaggc     4380

tagtggtttt ggccacagcc acgcctcccg gtacggtgac aactccccac agtaacatag     4440

aggaggtggc ccttggtcac gagggcgaga tcccttttta tggcaaagcc attcccctag     4500

ctttcatcaa ggggggcaga cacttgatct tttgccattc aaagaagaag tgcgacgagc     4560

tcgcagcggc cctccggggc atgggtgtca atgccgttgc atactatagg ggtctcgacg     4620

tctccgttat accaactcaa ggagacgtgg tggttgtcgc cactgatgcc ctaatgactg     4680

ggtacaccgg cgactttgac tctgtcatcg actgtaatgt tgcagtctct cagattgttg     4740

acctcagcct agacccaacc ttcaccatca ccactcaaat cgtccctcag gacgctgtct     4800

cccgtagtca acgtagaggg agaactggga gggggcgatt gggcgtttac aggtatgttt     4860

cgtcaggcga aaggccgtct gggatgttcg acagcgtagt gctctgcgag tgctatgatg     4920

ccggggcagc ctggtacgag cttacacctg ctgagactac ggtgagactc cgggcttatt     4980

tcaacacgcc cggtttgccc gtatgtcaag accacctgga gttctgggaa gcggtcttta     5040

caggtctcac acacattgac gcccacttcc tctcccagac gaagcaagga ggagaaaact     5100

ttgcgtatct aacggcctac caggccacag tatgcgccag ggcaaaggcc cctcctcctt     5160

cgtgggacgt gatgtggaag tgtctaacta ggctcaaacc tacactgact ggtcccaccc     5220

ccctcctgta ccgcttgggt gccgtgacca atgaggtcac cttgacgcac cccgtgacga     5280

aatacatcgc cacgtgcatg caagctgacc tcgagatcat gacaagctca tgggtcctgg     5340

cggggggggt gctagccgcc gtggcatctt actgcctggc gactggctgc atttccatca     5400

ttggccgcct acacctgaat gatcgggtgg ttgtggcccc cgacaaggaa atcttatatg     5460

aggcctttga tgagatggaa gaatgcgcct ccaaagccgc cctcattgag gaagggcagc     5520

ggatggcgga gatgctcaaa tctaagatac aaggcctcct acaacaggcc acaaggcaag     5580

ctcaagacat acagccagct atacagtcat catggcccaa gcttgaacaa ttttgggcca     5640

aacacatgtg gaacttcatc agtggtatac agtacctagc aggactctcc accctaccgg     5700

gaaatcctgc agtagcatca atgatggctt ttagcgccgc gctgactagc ccactaccca     5760

ccagcaccac catcctcttg aacatcatgg gaggatggtt ggcctctcag attgcccccc     5820

ctgccggagc cactggcttc gttgtcagtg gtctagtggg ggcggccgtc ggaagcatag     5880

gcctgggtaa gatactggtg gacgttttgg ccgggtacgg cgcaggcatt tcaggggccc     5940

tcgtagcttt taagatcatg agcggcgaga agcccacggt agaagacgtt gtgaatctcc     6000

tgcctgctat tctgtctcct ggtgcgttgg tagtgggagt catctgtgca gcaatcctgc     6060

gccgccacgt cggtcaggga gagggggcgg tccagtggat gaacagactg atcgccttcg     6120

cctccagggg aaaccacgtt gcccctaccc actacgtggt ggagtctgac gcttcacagc     6180

gtgtaacgca ggtgctgagt tcacttacaa ttaccagctt acttaggaga ctacatgcct     6240

gggtcactga agattgccca gtcccatgct cggggtcttg gctccaggac atttgggatt     6300

gggtttgttc catcctcaca gacttcaaaa actggctgtc ttcaaaatta ctccccaaga     6360

tgcccggcat tccctttatc tcttgccaga agggatacaa gggtgtatgg gctggtacgg     6420

gtgtcatgac tactcggtgc ccatgtggag caaacatctc gggccatgtc cgcatgggca     6480

ccatgaaaat aacaggcccg aagacttgct tgaacctgtg gcaggggact ttccccatta     6540

attgttacac agaagggcct tgcgtgccaa aaccccctcc taattacaag accgcaattt     6600

ggagggtggc agcgtcggag tacgttgagg tcacacagca tggctctttc tcgtatgtaa     6660

cagggttaac cagtgacaac cttaaggtcc cttgccaggt accagctcca gaatttttct     6720

cttgggtgga cggggtgcaa atccaccgat tcgcccccgt tccaggtccc ttctttcggg     6780

atgaggtaac gttcaccgta ggccttaact ccttcgtggt cggctctcag ctcccttgcg     6840

atcctgagcc ggacaccgag gtactggcct ccatgttgac agacccgtcc cacatcaccg     6900

cggaggcggc agccaggcga ttggcaaggg gatctccccc ttcacaggct agctcctcag     6960

cgagccagct ctctgccccg tccttgaagg ctacctgtac cacccataag acagcatatg     7020

attgtgacat ggtggatgcc aaccttttca tgggaggcga tgtgacccgg attgagtctg     7080

actctaaggt gatcgttctc gactccctcg attccatgac tgaggtagtg gatgatcgtg     7140

agccttctgt accatcagag tacctgatca agaggagaaa gttcccaccg gcgctgcctc     7200

cttgggcccg tccagactac aatcctgttt tgatcgagac atggaagagg ccgggctatg     7260

aaccacccac tgtcctaggc tgtgccctcc cccccacacc tcaaacgcca gtgcctccac     7320

ctcggaggcg ccgcgccaaa gtcctgaccc aggacaatgt ggaggggatc ctcagggaga     7380

tggctgacaa agtactcagc cctctccaag acaacaatga ctccggtcac tccactggag     7440

cggataccgg aggagacatc gtccagcaac cctctgacga gactgccgct tcagaagcgg     7500

ggtcactgtc ctccatgcct ccccttgagg gagagccggg agaccctgac ctggagtttg     7560

aaccagtggg atccgctccc ccttctgagg gggagtgtga ggtcattgat tcggactcta     7620

agtcgtggtc cacagtctct gatcaagagg attctgttat ctgctgctct atgtcatact     7680

cctggacggg ggccctcata acaccatgtg ggcccgaaga ggagaagtta ccgatcaacc     7740

ctctgagtaa ttcgctcatg cggttccata ataaggtgta ctccacaacc tcgaggagtg     7800

cctctctgag ggcaaagaag gtgacttttg acagggtgca ggtgctggac gcacactatg     7860

actcagtctt gcaggacgtt aagcgggccg cctctaaggt tagtgcgagg ctcctcacgg     7920

tagaggaagc ctgcgcgctg accccgcccc actccgccaa atcgcgatac ggatttgggg     7980

caaaagaggt gcgcagctta tccaggaggg ccgttaacca catccggtcc gtgtgggagg     8040

acctcctgga agaccaacat accccaattg acacaactat catggctaaa aatgaggtgt     8100

tctgcattga tccaactaaa ggtgggaaaa agccagctcg cctcatcgta taccccgacc     8160

ttggggtcag ggtgtgcgaa aagatggccc tctatgacat cgcacaaaag cttcccaaag     8220

cgataatggg gccatcctat gggttccaat actctcccgc agaacgggtc gatttcctcc     8280

tcaaagcttg gggaagtaag aaggacccaa tggggttctc gtatgacacc cgctgctttg     8340

actcaaccgt cacggagagg gacataagaa cagaagaatc catatatcag gcttgttctc     8400

tgcctcaaga agccagaact gtcatacact cgctcactga gagactttac gtaggagggc     8460

ccatgacaaa cagcaaaggg caatcctgcg gctacaggcg ttgccgcgca agcggtgttt     8520

tcaccaccag catggggaat accatgacat gttacatcaa agcccttgca gcgtgtaagg     8580

ctgcagggat cgtggaccct gttatgttgg tgtgtggaga cgacctggtc gtcatctcag     8640

agagccaagg taacgaggag gacgagcgaa acctgagagc tttcacggag gctatgacca     8700

ggtattccgc ccctcccggt gaccttccca gaccggaata tgacttggag cttataacat     8760

cctgctcctc aaacgtatcg gtagcgctgg actctcgggg tcgccgccgg tacttcctaa     8820

ccagagaccc taccactcca atcacccgag ctgcttggga aacagtaaga cactcccctg     8880

tcaattcttg gctgggcaac atcatccagt acgcccccac aatctgggtc cggatggtca     8940

taatgactca cttcttctcc atactattgg cccaggacac tctgaaccaa aatctcaatt     9000

ttgagatgta cggggcagta tactcggtca atccattaga cctaccggcc ataattgaaa     9060

ggctacatgg gcttgaagcc ttttcactgc acacatactc tccccgcgaa ctctcacggg     9120

tggcagcaac tctcagaaaa cttggagcgc ctccccttag agcgtggaag agtcgggcgc     9180

gtgccgtgag agcttcactc atcgcccaag gagcgagggc ggccatttgt ggccgctacc     9240

tcttcaactg ggcggtgaaa acaaagctca aactcactcc attgcccgag gcgagccgcc     9300

tggatttatc cgggtggttc accgtgggcg ccggcggggg cggcatttat cacagcgtgt     9360

cgcatgcccg accccgccta ttactccttt gcctactcct acttagcgta ggagtaggca     9420

tctttttact ccccgctcgg tagagcggca aaccctagct acactccata gctagtttcc     9480

gttttttttt ttttgttttt tttttttttt tttttttttt tttttttttt tttcttttcc     9540

tttttttttt ttctctttct tggtggctcc atcttagccc tagtcacggc tagctgtgaa     9600

aggtccgtga gccgcatgac tgcagagagt gccgtaactg gtctctctgc agatcatgt      9659


<210>  63
<211>  9659
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  63
gcccgccccc tgatgggggc gacactccgc catgaatcac tcccctgtga ggaactactg       60

tcttcacgca gaaagcgtct agccatggcg ttagtatgag tgtcgtacag cctccaggcc      120

cccccctccc gggagagcca tagtggtctg cggaaccggt gagtacaccg gaattaccgg      180

aaagactggg tcctttcttg gataaaccca ctctatgtcc ggtcatttgg gcacgccccc      240

gcaagactgc tagccgagta gcgttgggtt gcgaaaggcc ttgtggtact gcctgatagg      300

gtgcttgcga gtgccccggg aggtctcgta gaccgtgcat catgagcaca aatcctaaac      360

ctcaaagaaa aaccaaaaga aacacaaacc gccgcccaca ggacgttaag ttcccgggtg      420

gcggtcagat cgttggcgga gtttacttgc tgccgcgcag gggccccagg ttgggtgtgc      480

gcgcgacaag gaagacttct gagcgatccc agccgcgtgg acgacgccag cccatcccga      540

aagatcggcg ctccaccggc aagtcctggg gaaagccagg atatccttgg cccctgtacg      600

gaaacgaggg ttgcggctgg gcgggttggc tcctgtcccc ccgcgggtct cgtcctactt      660

ggggccccac cgacccccgg catagatcac gcaatttggg cagagtcatc gataccatta      720

cgtgtggttt tgccgacctc atggggtaca tccctgtcgt tggcgccccg gttggaggcg      780

tcgccagagc tctggcacac ggtgttaggg tcctggagga cgggataaat tacgcaacag      840

ggaatttacc cggttgctct ttttctatct ttttgcttgc tcttctgtca tgcgtcacag      900

tgccagtgtc tgcagtggaa gtcaggaaca ttagttctag ctactacgcc actaatgatt      960

gctcaaacaa cagcatcacc tggcagctca ctgacgcagt tctccatctt cctggatgcg     1020

tcccatgtga gaatgataat ggcaccttgc attgctggat acaagtaaca cccaacgtgg     1080

ctgtgaaaca ccgcggtgcg ctcactcgta gcctgcgaac acacgtcgac atgatcgtaa     1140

tggcagctac ggcctgctcg gccttgtatg tgggagatgt gtgcggggcc gtgatgattc     1200

tatcgcaggc tttcatggta tcaccacaac gccacaactt cacccaagag tgcaactgtt     1260

ccatctacca aggtcacatc accggccatc gcatggcatg ggacatgatg ctgaactggt     1320

ctccaactct tgccatgatc ctcgcctacg ccgctcgtgt tcccgagatg gtcctcgaaa     1380

ttattttcgg cggccattgg ggtgtggtgt ttggcttggc ctacttctcc atgcaaggag     1440

cgtgggccaa agtcattgcc atcctccttc ttgttgcggg agtggatgca accacctatt     1500

ccagcggcca ggaagcgggt cgtaccgtct tggggttcac taacctcttt acttctggtg     1560

ccaagcagaa cctctattta atcaacacca atggcagctg gcacataaac cggactgccc     1620

tcaattgcaa tgacagctta cagacgggtt tcatggcttc cctgttttac acccacaggt     1680

tcaacagctc tggctgcccc gagcgcttgt cttcctgccg cgggctggac gattttcgca     1740

tcggctgggg aaccttggaa tacgaaaccc acgtcaccaa cgatgaggac atgaggccgt     1800

actgctggca ttaccctccg aggccttgcg gcatcgtccc ggctagaacg gtttgcggac     1860

cggtctattg tttcacccct agccctgttg tcgtgggcac cactgacaag cagggcgtac     1920

ccacctacac ctggggggaa aacgagaccg atgtcttcct gctgaatagc acaagacccc     1980

cgcgaggagc ttggttcggc tgcacttgga tgaacgggac tgggttcact aagacatgcg     2040

gtgcaccacc ttgccgcatt aggaaagact acaacagcac tatcgattta ttgtgcccca     2100

cagactgttt taggaagcac cccgatgcta cctatcttaa gtgtggagca gggccttggt     2160

taactcccag gtgcctggta gactaccctt atagactgtg gcattatccg tgcactgtaa     2220

acttcaccat ctttaaggcg cggatgtatg taggaggggt ggagcatcga ttctccgcag     2280

catgcaactt cacgcgcgga gatcgctgca gactggaaga tagggatagg ggtcagcaga     2340

gtccactgct gcattccact actgagtggg cggtgctccc atgctccttc tctgacctac     2400

cagcactatc cactggccta ttgcacctcc accaaaacat cgtggacgtg cagtaccttt     2460

acggactttc tccggctctg acaagataca tcgtgaagtg ggagtgggtg atcctccttt     2520

tcttgttgtt ggcagacgcc aggatctgtg catgcctttg gatgctcatc atactgggcc     2580

aagccgaagc ggcgcttgag aagctcatca tcttgcactc cgctagtgct gctagtgcca     2640

atggtccgct gtggtgtttc atcttcttta cagcggcctg gtacttaaag ggcagggtgg     2700

tccccgtggc cacgtactct gttctcggct tatggtcctt cctcctccta gtcctggcct     2760

taccacagca ggcttatgcc ttggacgctg ctgaacaagg ggaactgggg ctggccatat     2820

tagtaattat atccatcttt actcttaccc cagcatacaa gatcctcctg agccgttcag     2880

tgtggtggct gtcctacatg ctggtcttgg ccgaggccca gattcagcaa cgggttcccc     2940

ccctggaggt ccgagggggg cgtgacggaa tcatctgggt ggctgtcatt ctacacccac     3000

gccttgtgtt tgaggtcacg aaatggttgt tagcaatcct ggggcctgcc tacctcctta     3060

aagcgtctct gctacggata ccgtactttg tgagggccca cgctttgcta cgagtgtgta     3120

ccctggtgaa acacctcgcg ggggctaggt acatccagat gctgttgatc accataggca     3180

gatggaccgg cacttacatc tacgaccacc tctccccttt atcaacttgg gcggcccagg     3240

gtttgcggga cctggcaatc gccgtggagc ctgtggtgtt cagcccaatg gagaagaagg     3300

tcattgtgtg gggggctgag acagtggcgt gtggagacat cctgcatggc ctcccggtct     3360

ccgcgaggct aggtagggag gttctgctcg gccctgccga cggctacacc tccaaggggt     3420

ggaagctcct agctcccatt actgcttaca ctcagcaaac tcgtggtctc ctgggtgcta     3480

tcgtggtcag cctaacgggc cgcgacaaaa atgagcaggc tgggcaggtc caggttctgt     3540

cctccgtcac acaaactttc ttggggacat ccatttcggg cgtcctctgg acagtatatc     3600

acggggctgg taataagacc ttggccggcc ccaagggacc agtcactcag atgtacacca     3660

gcgcagaagg ggacctcgtg ggatggccta gtccccccgg gactaagtca ttggacccct     3720

gtacctgcgg ggccgtagac ctctacctgg tcacccgaaa cgctgatgtc attccggtcc     3780

ggaggaaaga tgaccgacgg ggtgcattac tctcgccaag gcccctctca accctcaaag     3840

gatcatccgg agggcccgtg ctctgctcaa ggggacacgc cgtgggcttg ttcagagcgg     3900

ccgtgtgtgc caggggtgta gccaaatcta ttgacttcat ccccgtcgaa tcactcgatg     3960

tcgccacacg gacgcccagt ttctctgaca acagtacgcc gccagctgtg ccccagtctt     4020

accaggtggg ttacttgcac gcaccaacag gcagcggaaa gagcaccaag gtccctgccg     4080

cgtatgccag tcaggggtat aaagtactcg tactaaatcc ctctgtcgcg gccacacttg     4140

gttttggggc ctacatgtcc aaagcccacg ggatcaaccc taatatcaga actggagtgc     4200

ggaccgttac caccggggac tctatcactt actccactta tggcaagttt atcgcagatg     4260

gaggctgtgc agccggtgcc tatgacatca tcatatgcga cgaatgccat tcagtggacg     4320

ctactaccat ccttggcatt ggaacagtcc ttgaccaagc tgagaccgca ggcgtcaggc     4380

tagtggtttt ggccacagcc acgcctcccg gtacggtgac aactccccac agtaacatag     4440

aggaggtggc ccttggtcac gagggcgaga tcccttttta tggcaaagcc attcccctag     4500

ctttcatcaa ggggggcaga cacttgatct tttgccattc aaagaagaag tgcgacgagc     4560

tcgcagcggc cctccggggc atgggtgtca atgccgttgc atactatagg ggtctcgacg     4620

tctccgttat accaactcaa ggagacgtgg tggttgtcgc cactgatgcc ctaatgactg     4680

ggtacaccgg cgactttgac tctgtcatcg actgtaatgt tgcagtctct cagattgttg     4740

acctcagcct agacccaacc ttcaccatca ccactcaaat cgtccctcag gacgctgtct     4800

cccgtagtca acgtagaggg agaactggga gggggcgatt gggcgtttac aggtatgttt     4860

cgtcaggcga aaggccgtct gggatgttcg acagcgtagt gctctgcgag tgctatgatg     4920

ccggggcagc ctggtacgag cttacacctg ctgagactac ggtgagactc cgggcttatt     4980

tcaacacgcc cggtttgccc gtatgtcaag accacctgga gttctgggaa gcggtcttta     5040

caggtctcac acacattgac gcccacttcc tctcccagac gaagcaagga ggagaaaact     5100

ttgcgtatct aacggcctac caggccacag tatgcgccag ggcaaaggcc cctcctcctt     5160

cgtgggacgt gatgtggaag tgtctaacta ggctcaaacc tacactgact ggtcccaccc     5220

ccctcctgta ccgcttgggt gccgtgacca atgaggtcac cttgacgcac cccgtgacga     5280

aatacatcgc cacgtgcatg caagctgacc tcgagatcat gacaagctca tgggtcctgg     5340

cggggggggt gctagccgcc gtggcatctt actgcctggc gactggctgc atttccatca     5400

ttggccgcct acacctgaat gatcgggtgg ttgtggcccc cgacaaggaa atcttatatg     5460

aggcctttga tgagatggaa gaatgcgcct ccaaagccgc cctcattgag gaagggcagc     5520

ggatggcgga gatgctcaaa tctaagatac aaggcctcct acaacaggcc acaaggcaag     5580

ctcaagacat acagccagct atacagtcat catggcccaa gcttgaacaa ttttgggcca     5640

aacacatgtg gaacttcatc agtggtatac agtacctagc aggactctcc accctaccgg     5700

gaaatcctgc agtagcatca atgatggctt ttagcgccgc gctgactagc ccactaccca     5760

ccagcaccac catcctcttg aacatcatgg gaggatggtt ggcctctcag attgcccccc     5820

ctgccggagc cactggcttc gttgtcagtg gtctagtggg ggcggccgtc ggaagcatag     5880

gcctgggtaa gatactggtg gacgttttgg ccgggtacgg cgcaggcatt tcaggggccc     5940

tcgtagcttt taagatcatg agcggcgaga agcccacggt agaagacgtt gtgaatctcc     6000

tgcctgctat tctgtctcct ggtgcgttgg tagtgggagt catctgtgca gcaatcctgc     6060

gccgccacgt cggtcaggga gagggggcgg tccagtggat gaacagactg atcgccttcg     6120

cctccagggg aaaccacgtt gcccctaccc actacgtggt ggagtctgac gcttcacagc     6180

gtgtaacgca ggtgctgagt tcacttacaa ttaccagctt acttaggaga ctacatgcct     6240

gggtcactga agattgccca gtcccatgct cggggtcttg gctccaggac atttgggatt     6300

gggtttgttc catcctcaca gacttcaaaa actggctgtc ttcaaaatta ctccccaaga     6360

tgcccggcat tccctttatc tcttgccaga agggatacaa gggtgtatgg gctggtacgg     6420

gtgtcatgac tactcggtgc ccatgtggag caaacatctc gggccatgtc cgcatgggca     6480

ccatgaaaat aacaggcccg aagacttgct tgaacctgtg gcaggggact ttccccatta     6540

attgttacac agaagggcct tgcgtgccaa aaccccctcc taattacaag accgcaattt     6600

ggagggtggc agcgtcggag tacgttgagg tcacacagca tggctctttc tcgtatgtaa     6660

cagggttaac cagtgacaac cttaaggtcc cttgccaggt accagctcca gaatttttct     6720

cttgggtgga cggggtgcaa atccaccgat tcgcccccgt tccaggtccc ttctttcggg     6780

atgaggtaac gttcaccgta ggccttaact ccttcgtggt cggctctcag ctcccttgcg     6840

atcctgagcc ggacaccgag gtactggcct ccatgttgac agacccgtcc cacatcaccg     6900

cggaggcggc agccaggcga ttggcaaggg gatctccccc ttcacaggct agctcctcag     6960

cgagccagct ctctgccccg tccttgaagg ctacctgtac cacccataag acagcatatg     7020

attgtgacat ggtggatgcc aaccttttca tgggaggcga tgtgacccgg attgagtctg     7080

actctaaggt gatcgttctc gactccctcg attccatgac tgaggtagag gatgatcgtg     7140

agccttctgt accatcagag tacctgatca agaggagaaa gttcccaccg gcgctgcctc     7200

cttgggcccg tccagactac aatcctgttt tgatcgagac atggaagagg ccgggctatg     7260

aaccacccac tgtcctaggc tgtgccctcc cccccacacc tcaaacgcca gtgcctccac     7320

ctcggaggcg ccgcgccaaa gtcctgaccc aggacaatgt ggaggggatc ctcagggaga     7380

tggctgacaa agtactcagc cctctccaag acaacaatga ctccggtcac tccactggag     7440

cggataccgg aggagacatc gtccagcaac cctctgacga gactgccgct tcagaagcgg     7500

ggtcactgtc ctccatgcct ccccttgagg gagagccggg agaccctgac ctggagtttg     7560

aaccagtggg atccgctccc ccttctgagg gggagtgtga ggtcattgat tcggactcta     7620

agtcgtggtc cacagtctct gatcaagagg attctgttat ctgctgctct atgtcatact     7680

cctggacggg ggccctcata acaccatgtg ggcccgaaga ggagaagtta ccgatcaacc     7740

ctctgagtaa ttcgctcatg cggttccata ataaggtgta ctccacaacc tcgaggagtg     7800

cctctctgag ggcaaagaag gtgacttttg acagggtgca ggtgctggac gcacactatg     7860

actcagtctt gcaggacgtt aagcgggccg cctctaaggt tagtgcgagg ctcctcacgg     7920

tagaggaagc ctgcgcgctg accccgcccc actccgccaa atcgcgatac ggatttgggg     7980

caaaagaggt gcgcagctta tccaggaggg ccgttaacca catccggtcc gtgtgggagg     8040

acctcctgga agaccaacat accccaattg acacaactat catggctaaa aatgaggtgt     8100

tctgcattga tccaactaaa ggtgggaaaa agccagctcg cctcatcgta taccccgacc     8160

ttggggtcag ggtgtgcgaa aagatggccc tctatgacat cgcacaaaag cttcccaaag     8220

cgataatggg gccatcctat gggttccaat actctcccgc agaacgggtc gatttcctcc     8280

tcaaagcttg gggaagtaag aaggacccaa tggggttctc gtatgacacc cgctgctttg     8340

actcaaccgt cacggagagg gacataagaa cagaagaatc catatatcag gcttgttctc     8400

tgcctcaaga agccagaact gtcatacact cgctcactga gagactttac gtaggagggc     8460

ccatgacaaa cagcaaaggg caatcctgcg gctacaggcg ttgccgcgca agcggtgttt     8520

tcaccaccag catggggaat accatgacat gttacatcaa agcccttgca gcgtgtaagg     8580

ctgcagggat cgtggaccct gttatgttgg tgtgtggaga cgacctggtc gtcatctcag     8640

agagccaagg taacgaggag gacgagcgaa acctgagagc tttcacggag gctatgacca     8700

ggtattccgc ccctcccggt gaccttccca gaccggaata tgacttggag cttataacat     8760

cctgctcctc aaacgtatcg gtagcgctgg actctcgggg tcgccgccgg tacttcctaa     8820

ccagagaccc taccactcca atcacccgag ctgcttggga aacagtaaga cactcccctg     8880

tcaattcttg gctgggcaac atcatccagt acgcccccac aatctgggtc cggatggtca     8940

taatgactca cttcttctcc atactattgg cccaggacac tctgaaccaa aatctcaatt     9000

ttgagatgta cggggcagta tactcggtca atccattaga cctaccggcc ataattgaaa     9060

ggctacatgg gcttgaagcc ttttcactgc acacatactc tccccgcgaa ctctcacggg     9120

tggcagcaac tctcagaaaa cttggagcgc ctccccttag agcgtggaag agtcgggcgc     9180

gtgccgtgag agcttcactc atcgcccaag gagcgagggc ggccatttgt ggccgctacc     9240

tcttcaactg ggcggtgaaa acaaagctca aactcactcc attgcccgag gcgagccgcc     9300

tggatttatc cgggtggttc accgtgggcg ccggcggggg cggcatttat cacagcgtgt     9360

cgcatgcccg accccgccta ttactccttt gcctactcct acttagcgta ggagtaggca     9420

tctttttact ccccgctcgg tagagcggca aaccctagct acactccata gctagtttcc     9480

gttttttttt ttttgttttt tttttttttt tttttttttt tttttttttt tttcttttcc     9540

tttttttttt ttctctttct tggtggctcc atcttagccc tagtcacggc tagctgtgaa     9600

aggtccgtga gccgcatgac tgcagagagt gccgtaactg gtctctctgc agatcatgt      9659


<210>  64
<211>  9659
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  64
gcccgccccc tgatgggggc gacactccgc catgaatcac tcccctgtga ggaactactg       60

tcttcacgca gaaagcgtct agccatggcg ttagtatgag tgtcgtacag cctccaggcc      120

cccccctccc gggagagcca tagtggtctg cggaaccggt gagtacaccg gaattaccgg      180

aaagactggg tcctttcttg gataaaccca ctctatgtcc ggtcatttgg gcacgccccc      240

gcaagactgc tagccgagta gcgttgggtt gcgaaaggcc ttgtggtact gcctgatagg      300

gtgcttgcga gtgccccggg aggtctcgta gaccgtgcat catgagcaca aatcctaaac      360

ctcaaagaaa aaccaaaaga aacacaaacc gccgcccaca ggacgttaag ttcccgggtg      420

gcggtcagat cgttggcgga gtttacttgc tgccgcgcag gggccccagg ttgggtgtgc      480

gcgcgacaag gaagacttct gagcgatccc agccgcgtgg acgacgccag cccatcccga      540

aagatcggcg ctccaccggc aagtcctggg gaaagccagg atatccttgg cccctgtacg      600

gaaacgaggg ttgcggctgg gcgggttggc tcctgtcccc ccgcgggtct cgtcctactt      660

ggggccccac cgacccccgg catagatcac gcaatttggg cagagtcatc gataccatta      720

cgtgtggttt tgccgacctc atggggtaca tccctgtcgt tggcgccccg gttggaggcg      780

tcgccagagc tctggcacac ggtgttaggg tcctggagga cgggataaat tacgcaacag      840

ggaatttacc cggttgctct ttttctatct ttttgcttgc tcttctgtca tgcgtcacag      900

tgccagtgtc tgcagtggaa gtcaggaaca ttagttctag ctactacgcc actaatgatt      960

gctcaaacaa cagcatcacc tggcagctca ctgacgcagt tctccatctt cctggatgcg     1020

tcccatgtga gaatgataat ggcaccttgc attgctggat acaagtaaca cccaacgtgg     1080

ctgtgaaaca ccgcggtgcg ctcactcgta gcctgcgaac acacgtcgac atgatcgtaa     1140

tggcagctac ggcctgctcg gccttgtatg tgggagatgt gtgcggggcc gtgatgattc     1200

tatcgcaggc tttcatggta tcaccacaac gccacaactt cacccaagag tgcaactgtt     1260

ccatctacca aggtcacatc accggccatc gcatggcatg ggacatgatg ctgaactggt     1320

ctccaactct tgccatgatc ctcgcctacg ccgctcgtgt tcccgagatg gtcctcgaaa     1380

ttattttcgg cggccattgg ggtgtggtgt ttggcttggc ctacttctcc atgcaaggag     1440

cgtgggccaa agtcattgcc atcctccttc ttgttgcggg agtggatgca accacctatt     1500

ccagcggcca ggaagcgggt cgtaccgtct tggggttcac taacctcttt acttctggtg     1560

ccaagcagaa cctctattta atcaacacca atggcagctg gcacataaac cggactgccc     1620

tcaattgcaa tgacagctta cagacgggtt tcatggcttc cctgttttac acccacaggt     1680

tcaacagctc tggctgcccc gagcgcttgt cttcctgccg cgggctggac gattttcgca     1740

tcggctgggg aaccttggaa tacgaaaccc acgtcaccaa cgatgaggac atgaggccgt     1800

actgctggca ttaccctccg aggccttgcg gcatcgtccc ggctagaacg gtttgcggac     1860

cggtctattg tttcacccct agccctgttg tcgtgggcac cactgacaag cagggcgtac     1920

ccacctacac ctggggggaa aacgagaccg atgtcttcct gctgaatagc acaagacccc     1980

cgcgaggagc ttggttcggc tgcacttgga tgaacgggac tgggttcact aagacatgcg     2040

gtgcaccacc ttgccgcatt aggaaagact acaacagcac tatcgattta ttgtgcccca     2100

cagactgttt taggaagcac cccgatgcta cctatcttaa gtgtggagca gggccttggt     2160

taactcccag gtgcctggta gactaccctt atagactgtg gcattatccg tgcactgtaa     2220

acttcaccat ctttaaggcg cggatgtatg taggaggggt ggagcatcga ttctccgcag     2280

catgcaactt cacgcgcgga gatcgctgca gactggaaga tagggatagg ggtcagcaga     2340

gtccactgct gcattccact actgagtggg cggtgctccc atgctccttc tctgacctac     2400

cagcactatc cactggccta ttgcacctcc accaaaacat cgtggacgtg cagtaccttt     2460

acggactttc tccggctctg acaagataca tcgtgaagtg ggagtgggtg atcctccttt     2520

tcttgttgtt ggcagacgcc aggatctgtg catgcctttg gatgctcatc atactgggcc     2580

aagccgaagc ggcgcttgag aagctcatca tcttgcactc cgctagtgct gctagtgcca     2640

atggtccgct gtggtgtttc atcttcttta cagcggcctg gtacttaaag ggcagggtgg     2700

tccccgtggc cacgtactct gttctcggct tatggtcctt cctcctccta gtcctggcct     2760

taccacagca ggcttatgcc ttggacgctg ctgaacaagg ggaactgggg ctggccatat     2820

tagtaattat atccatcttt actcttaccc cagcatacaa gatcctcctg agccgttcag     2880

tgtggtggct gtcctacatg ctggtcttgg ccgaggccca gattcagcaa cgggttcccc     2940

ccctggaggt ccgagggggg cgtgacggaa tcatctgggt ggctgtcatt ctacacccac     3000

gccttgtgtt tgaggtcacg aaatggttgt tagcaatcct ggggcctgcc tacctcctta     3060

aagcgtctct gctacggata ccgtactttg tgagggccca cgctttgcta cgagtgtgta     3120

ccctggtgaa acacctcgcg ggggctaggt acatccagat gctgttgatc accataggca     3180

gatggaccgg cacttacatc tacgaccacc tctccccttt atcaacttgg gcggcccagg     3240

gtttgcggga cctggcaatc gccgtggagc ctgtggtgtt cagcccaatg gagaagaagg     3300

tcattgtgtg gggggctgag acagtggcgt gtggagacat cctgcatggc ctcccggtct     3360

ccgcgaggct aggtagggag gttctgctcg gccctgccga cggctacacc tccaaggggt     3420

ggaagctcct agctcccatt actgcttaca ctcagcaaac tcgtggtctc ctgggtgcta     3480

tcgtggtcag cctaacgggc cgcgacaaaa atgagcaggc tgggcaggtc caggttctgt     3540

cctccgtcac acaaactttc ttggggacat ccatttcggg cgtcctctgg acagtatatc     3600

acggggctgg taataagacc ttggccggcc ccaagggacc agtcactcag atgtacacca     3660

gcgcagaagg ggacctcgtg ggatggccta gtccccccgg gactaagtca ttggacccct     3720

gtacctgcgg ggccgtagac ctctacctgg tcacccgaaa cgctgatgtc attccggtcc     3780

ggaggaaaga tgaccgacgg ggtgcattac tctcgccaag gcccctctca accctcaaag     3840

gatcatccgg agggcccgtg ctctgctcaa ggggacacgc cgtgggcttg ttcagagcgg     3900

ccgtgtgtgc caggggtgta gccaaatcta ttgacttcat ccccgtcgaa tcactcgatg     3960

tcaccacacg gacgcccagt ttctctgaca acagtacgcc gccagctgtg ccccagtctt     4020

accaggtggg ttacttgcac gcaccaacag gcagcggaaa gagcaccaag gtccctgccg     4080

cgtatgccag tcaggggtat aaagtactcg tactaaatcc ctctgtcgcg gccacacttg     4140

gttttggggc ctacatgtcc aaagcccacg ggatcaaccc taatatcaga actggagtgc     4200

ggaccgttac caccggggac tctatcactt actccactta tggcaagttt atcgcagatg     4260

gaggctgtgc agccggtgcc tatgacatca tcatatgcga cgaatgccat tcagtggacg     4320

ctactaccat ccttggcatt ggaacagtcc ttgaccaagc tgagaccgca ggcgtcaggc     4380

tagtggtttt ggccacagcc acgcctcccg gtacggtgac aactccccac agtaacatag     4440

aggaggtggc ccttggtcac gagggcgaga tcccttttta tggcaaagcc attcccctag     4500

ctttcatcaa ggggggcaga cacttgatct tttgccattc aaagaagaag tgcgacgagc     4560

tcgcagcggc cctccggggc atgggtgtca atgccgttgc atactatagg ggtctcgacg     4620

tctccgttat accaactcaa ggagacgtgg tggttgtcgc cactgatgcc ctaatgactg     4680

ggtacaccgg cgactttgac tctgtcatcg actgtaatgt tgcagtctct cagattgttg     4740

acctcagcct agacccaacc ttcaccatca ccactcaaat cgtccctcag gacgctgtct     4800

cccgtagtca acgtagaggg agaactggga gggggcgatt gggcgtttac aggtatgttt     4860

cgtcaggcga aaggccgtct gggatgttcg acagcgtagt gctctgcgag tgctatgatg     4920

ccggggcagc ctggtacgag cttacacctg ctgagactac ggtgagactc cgggcttatt     4980

tcaacacgcc cggtttgccc gtatgtcaag accacctgga gttctgggaa gcggtcttta     5040

caggtctcac acacattgac gcccacttcc tctcccagac gaagcaagga ggagaaaact     5100

ttgcgtatct aacggcctac caggccacag tatgcgccag ggcaaaggcc cctcctcctt     5160

cgtgggacgt gatgtggaag tgtctaacta ggctcaaacc tacactgact ggtcccaccc     5220

ccctcctgta ccgcttgggt gccgtgacca atgaggtcac cttgacgcac cccgtgacga     5280

aatacatcgc cacgtgcatg caagctgacc tcgagatcat gacaagctca tgggtcctgg     5340

cggggggggt gctagccgcc gtggcatctt actgcctggc gactggctgc atttccatca     5400

ttggccgcct acacctgaat gatcgggtgg ttgtggcccc cgacaaggaa atcttatatg     5460

aggcctttga tgagatggaa gaatgcgcct ccaaagccgc cctcattgag gaagggcagc     5520

ggatggcgga gatgctcaaa tctaagatac aaggcctcct acaacaggcc acaaggcaag     5580

ctcaagacat acagccagct atacagtcat catggcccaa gcttgaacaa ttttgggcca     5640

aacacatgtg gaacttcatc agtggtatac agtacctagc aggactctcc accctaccgg     5700

gaaatcctgc agtagcatca atgatggctt ttagcgccgc gctgactagc ccactaccca     5760

ccagcaccac catcctcttg aacatcatgg gaggatggtt ggcctctcag attgcccccc     5820

ctgccggagc cactggcttc gttgtcagtg gtctagtggg ggcggccgtc ggaagcatag     5880

gcctgggtaa gatactggtg gacgttttgg ccgggtacgg cgcaggcatt tcaggggccc     5940

tcgtagcttt taagatcatg agcggcgaga agcccacggt agaagacgtt gtgaatctcc     6000

tgcctgctat tctgtctcct ggtgcgttgg tagtgggagt catctgtgca gcaatcctgc     6060

gccgccacgt cggtcaggga gagggggcgg tccagtggat gaacagactg atcgccttcg     6120

cctccagggg aaaccacgtt gcccctaccc actacgtggt ggagtctgac gcttcacagc     6180

gtgtaacgca ggtgctgagt tcacttacaa ttaccagctt acttaggaga ctacatgcct     6240

gggtcactga agattgccca gtcccatgct cggggtcttg gctccaggac atttgggatt     6300

gggtttgttc catcctcaca gacttcaaaa actggctgtc ttcaaaatta ctccccaaga     6360

tgcccggcat tccctttatc tcttgccaga agggatacaa gggtgtatgg gctggtacgg     6420

gtgtcatgac tactcggtgc ccatgtggag caaacatctc gggccatgtc cgcatgggca     6480

ccatgaaaat aacaggcccg aagacttgct tgaacctgtg gcaggggact ttccccatta     6540

attgttacac agaagggcct tgcgtgccaa aaccccctcc taattacaag accgcaattt     6600

ggagggtggc agcgtcggag tacgttgagg tcacacagca tggctctttc tcgtatgtaa     6660

cagggttaac cagtgacaac cttaaggtcc cttgccaggt accagctcca gaatttttct     6720

cttgggtgga cggggtgcaa atccaccgat tcgcccccgt tccaggtccc ttctttcggg     6780

atgaggtaac gttcaccgta ggccttaact ccttcgtggt cggctctcag ctcccttgcg     6840

atcctgagcc ggacaccgag gtactggcct ccatgttgac agacccgtcc cacatcaccg     6900

cggaggcggc agccaggcga ttggcaaggg gatctccccc ttcacaggct agctcctcag     6960

cgagccagct ctctgccccg tccttgaagg ctacctgtac cacccataag acagcatatg     7020

attgtgacat ggtggatgcc aaccttttca tgggaggcga tgtgacccgg attgagtctg     7080

actctaaggt gatcgttctc gactccctcg attccatgac tgaggtagtg gatgatcgtg     7140

agccttctgt accatcagag tacctgatca agaggagaaa gttcccaccg gcgctgcctc     7200

cttgggcccg tccagactac aatcctgttt tgatcgagac atggaagagg ccgggctatg     7260

aaccacccac tgtcctaggc tgtgccctcc cccccacacc tcaaacgcca gtgcctccac     7320

ctcggaggcg ccgcgccaaa gtcctgaccc aggacaatgt ggaggggatc ctcagggaga     7380

tggctgacaa agtactcagc cctctccaag acaacaatga ctccggtcac tccactggag     7440

cggataccgg aggagacatc gtccagcaac cctctgacga gactgccgct tcagaagcgg     7500

ggtcactgtc ctccatgcct ccccttgagg gagagccggg agaccctgac ctggagtttg     7560

aaccagtggg atccgctccc ccttctgagg gggagtgtga ggtcattgat tcggactcta     7620

agtcgtggtc cacagtctct gatcaagagg attctgttat ctgctgctct atgtcatact     7680

cctggacggg ggccctcata acaccatgtg ggcccgaaga ggagaagtta ccgatcaacc     7740

ctctgagtaa ttcgctcatg cggttccata ataaggtgta ctccacaacc tcgaggagtg     7800

cctctctgag ggcaaagaag gtgacttttg acagggtgca ggtgctggac gcacactatg     7860

actcagtctt gcaggacgtt aagcgggccg cctctaaggt tagtgcgagg ctcctcacgg     7920

tagaggaagc ctgcgcgctg accccgcccc actccgccaa atcgcgatac ggatttgggg     7980

caaaagaggt gcgcagctta tccaggaggg ccgttaacca catccggtcc gtgtgggagg     8040

acctcctgga agaccaacat accccaattg acacaactat catggctaaa aatgaggtgt     8100

tctgcattga tccaactaaa ggtgggaaaa agccagctcg cctcatcgta taccccgacc     8160

ttggggtcag ggtgtgcgaa aagatggccc tctatgacat cgcacaaaag cttcccaaag     8220

cgataatggg gccatcctat gggttccaat actctcccgc agaacgggtc gatttcctcc     8280

tcaaagcttg gggaagtaag aaggacccaa tggggttctc gtatgacacc cgctgctttg     8340

actcaaccgt cacggagagg gacataagaa cagaagaatc catatatcag gcttgttctc     8400

tgcctcaaga agccagaact gtcatacact cgctcactga gagactttac gtaggagggc     8460

ccatgacaaa cagcaaaggg caatcctgcg gctacaggcg ttgccgcgca agcggtgttt     8520

tcaccaccag catggggaat accatgacat gttacatcaa agcccttgca gcgtgtaagg     8580

ctgcagggat cgtggaccct gttatgttgg tgtgtggaga cgacctggtc gtcatctcag     8640

agagccaagg taacgaggag gacgagcgaa acctgagagc tttcacggag gctatgacca     8700

ggtattccgc ccctcccggt gaccttccca gaccggaata tgacttggag cttataacat     8760

cctgctcctc aaacgtatcg gtagcgctgg actctcgggg tcgccgccgg tacttcctaa     8820

ccagagaccc taccactcca atcacccgag ctgcttggga aacagtaaga cactcccctg     8880

tcaattcttg gctgggcaac atcatccagt acgcccccac aatctgggtc cggatggtca     8940

taatgactca cttcttctcc atactattgg cccaggacac tctgaaccaa aatctcaatt     9000

ttgagatgta cggggcagta tactcggtca gtccattaga cctaccggcc ataattgaaa     9060

ggctacatgg gcttgaagcc ttttcactgc acacatactc tccccgcgaa ctctcacggg     9120

tggcagcaac tctcagaaaa cttggagcgc ctccccttag agcgtggaag agtcgggcgc     9180

gtgccgtgag agcttcactc atcgcccaag gagcgagggc ggccatttgt ggccgctacc     9240

tcttcaactg ggcggtgaaa acaaagctca aactcactcc attgcccgag gcgagccgcc     9300

tggatttatc cgggtggttc accgtgggcg ccggcggggg cggcatttat cacagcgtgt     9360

cgcatgcccg accccgccta ttactccttt gcctactcct acttagcgta ggagtaggca     9420

tctttttact ccccgctcgg tagagcggca aaccctagct acactccata gctagtttcc     9480

gttttttttt ttttgttttt tttttttttt tttttttttt tttttttttt tttcttttcc     9540

tttttttttt ttctctttct tggtggctcc atcttagccc tagtcacggc tagctgtgaa     9600

aggtccgtga gccgcatgac tgcagagagt gccgtaactg gtctctctgc agatcatgt      9659


<210>  65
<211>  9659
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  65
gcccgccccc tgatgggggc gacactccgc catgaatcac tcccctgtga ggaactactg       60

tcttcacgca gaaagcgtct agccatggcg ttagtatgag tgtcgtacag cctccaggcc      120

cccccctccc gggagagcca tagtggtctg cggaaccggt gagtacaccg gaattaccgg      180

aaagactggg tcctttcttg gataaaccca ctctatgtcc ggtcatttgg gcacgccccc      240

gcaagactgc tagccgagta gcgttgggtt gcgaaaggcc ttgtggtact gcctgatagg      300

gtgcttgcga gtgccccggg aggtctcgta gaccgtgcat catgagcaca aatcctaaac      360

ctcaaagaaa aaccaaaaga aacacaaacc gccgcccaca ggacgttaag ttcccgggtg      420

gcggtcagat cgttggcgga gtttacttgc tgccgcgcag gggccccagg ttgggtgtgc      480

gcgcgacaag gaagacttct gagcgatccc agccgcgtgg acgacgccag cccatcccga      540

aagatcggcg ctccaccggc aagtcctggg gaaagccagg atatccttgg cccctgtacg      600

gaaacgaggg ttgcggctgg gcgggttggc tcctgtcccc ccgcgggtct cgtcctactt      660

ggggccccac cgacccccgg catagatcac gcaatttggg cagagtcatc gataccatta      720

cgtgtggttt tgccgacctc atggggtaca tccctgtcgt tggcgccccg gttggaggcg      780

tcgccagagc tctggcacac ggtgttaggg tcctggagga cgggataaat tacgcaacag      840

ggaatttacc cggttgctct ttttctatct ttttgcttgc tcttctgtca tgcgtcacag      900

tgccagtgtc tgcagtggaa gtcaggaaca ttagttctag ctactacgcc actaatgatt      960

gctcaaacaa cagcatcacc tggcagctca ctgacgcagt tctccatctt cctggatgcg     1020

tcccatgtga gaatgataat ggcaccttgc attgctggat acaagtaaca cccaacgtgg     1080

ctgtgaaaca ccgcggtgcg ctcactcgta gcctgcgaac acacgtcgac atgatcgtaa     1140

tggcagctac ggcctgctcg gccttgtatg tgggagatgt gtgcggggcc gtgatgattc     1200

tatcgcaggc tttcatggta tcaccacaac gccacaactt cacccaagag tgcaactgtt     1260

ccatctacca aggtcacatc accggccatc gcatggcatg ggacatgatg ctgaactggt     1320

ctccaactct tgccatgatc ctcgcctacg ccgctcgtgt tcccgagatg gtcctcgaaa     1380

ttattttcgg cggccattgg ggtgtggtgt ttggcttggc ctacttctcc atgcaaggag     1440

cgtgggccaa agtcattgcc atcctccttc ttgttgcggg agtggatgca accacctatt     1500

ccagcggcca ggaagcgggt cgtaccgtct tggggttcac taacctcttt acttctggtg     1560

ccaagcagaa cctctattta atcaacacca atggcagctg gcacataaac cggactgccc     1620

tcaattgcaa tgacagctta cagacgggtt tcatggcttc cctgttttac acccacaggt     1680

tcaacagctc tggctgcccc gagcgcttgt cttcctgccg cgggctggac gattttcgca     1740

tcggctgggg aaccttggaa tacgaaaccc acgtcaccaa cgatgaggac atgaggccgt     1800

actgctggca ttaccctccg aggccttgcg gcatcgtccc ggctagaacg gtttgcggac     1860

cggtctattg tttcacccct agccctgttg tcgtgggcac cactgacaag cagggcgtac     1920

ccacctacac ctggggggaa aacgagaccg atgtcttcct gctgaatagc acaagacccc     1980

cgcgaggagc ttggttcggc tgcacttgga tgaacgggac tgggttcact aagacatgcg     2040

gtgcaccacc ttgccgcatt aggaaagact acaacagcac tatcgattta ttgtgcccca     2100

cagactgttt taggaagcac cccgatgcta cctatcttaa gtgtggagca gggccttggt     2160

taactcccag gtgcctggta gactaccctt atagactgtg gcattatccg tgcactgtaa     2220

acttcaccat ctttaaggcg cggatgtatg taggaggggt ggagcatcga ttctccgcag     2280

catgcaactt cacgcgcgga gatcgctgca gactggaaga tagggatagg ggtcagcaga     2340

gtccactgct gcattccact actgagtggg cggtgctccc atgctccttc tctgacctac     2400

cagcactatc cactggccta ttgcacctcc accaaaacat cgtggacgtg cagtaccttt     2460

acggactttc tccggctctg acaagataca tcgtgaagtg ggagtgggtg atcctccttt     2520

tcttgttgtt ggcagacgcc aggatctgtg catgcctttg gatgctcatc atactgggcc     2580

aagccgaagc ggcgcttgag aagctcatca tcttgcactc cgctagtgct gctagtgcca     2640

atggtccgct gtggtgtttc atcttcttta cagcggcctg gtacttaaag ggcagggtgg     2700

tccccgtggc cacgtactct gttctcggct tatggtcctt cctcctccta gtcctggcct     2760

taccacagca ggcttatgcc ttggacgctg ctgaacaagg ggaactgggg ctggccatat     2820

tagtaattat atccatcttt actcttaccc cagcatacaa gatcctcctg agccgttcag     2880

tgtggtggct gtcctacatg ctggtcttgg ccgaggccca gattcagcaa cgggttcccc     2940

ccctggaggt ccgagggggg cgtgacggaa tcatctgggt ggctgtcatt ctacacccac     3000

gccttgtgtt tgaggtcacg aaatggttgt tagcaatcct ggggcctgcc tacctcctta     3060

aagcgtctct gctacggata ccgtactttg tgagggccca cgctttgcta cgagtgtgta     3120

ccctggtgaa acacctcgcg ggggctaggt acatccagat gctgttgatc accataggca     3180

gatggaccgg cacttacatc tacgaccacc tctccccttt atcaacttgg gcggcccagg     3240

gtttgcggga cctggcaatc gccgtggagc ctgtggtgtt cagcccaatg gagaagaagg     3300

tcattgtgtg gggggctgag acagtggcgt gtggagacat cctgcatggc ctcccggtct     3360

ccgcgaggct aggtagggag gttctgctcg gccctgccga cggctacacc tccaaggggt     3420

ggaagctcct agctcccatt actgcttaca ctcagcaaac tcgtggtctc ctgggtgcta     3480

tcgtggtcag cctaacgggc cgcgacaaaa atgagcaggc tgggcaggtc caggttctgt     3540

cctccgtcac acaaactttc ttggggacat ccatttcggg cgtcctctgg acagtatatc     3600

acggggctgg taataagacc ttggccggcc ccaagggacc agtcactcag atgtacacca     3660

gcgcagaagg ggacctcgtg ggatggccta gtccccccgg gactaagtca ttggacccct     3720

gtacctgcgg ggccgtagac ctctacctgg tcacccgaaa cgctgatgtc attccggtcc     3780

ggaggaaaga tgaccgacgg ggtgcattac tctcgccaag gcccctctca accctcaaag     3840

gatcatccgg agggcccgtg ctctgctcaa ggggacacgc cgtgggcttg ttcagagcgg     3900

ccgtgtgtgc caggggtgta gccaaatcta ttgacttcat ccccgtcgaa tcactcgatg     3960

tcaccacacg gacgcccagt ttctctgaca acagtacgcc gccagctgtg ccccagtctt     4020

accaggtggg ttacttgcac gcaccaacag gcagcggaaa gagcaccaag gtccctgccg     4080

cgtatgccag tcaggggtat aaagtactcg tactaaatcc ctctgtcgcg gccacacttg     4140

gttttggggc ctacatgtcc aaagcccacg ggatcaaccc taatatcaga actggagtgc     4200

ggaccgttgc caccggggac tctatcactt actccactta tggcaagttt atcgcagatg     4260

gaggctgtgc agccggtgcc tatgacatca tcatatgcga cgaatgccat tcagtggacg     4320

ctactaccat ccttggcatt ggaacagtcc ttgaccaagc tgagaccgca ggcgtcaggc     4380

tagtggtttt ggccacagcc acgcctcccg gtacggtgac aactccccac agtaacatag     4440

aggaggtggc ccttggtcac gagggcgaga tcccttttta tggcaaagcc attcccctag     4500

ctttcatcaa ggggggcaga cacttgatct tttgccattc aaagaagaag tgcgacgagc     4560

tcgcagcggc cctccggggc atgggtgtca atgccgttgc atactatagg ggtctcgacg     4620

tctccgttat accaactcaa ggagacgtgg tggttgtcgc cactgatgcc ctaatgactg     4680

ggtacaccgg cgactttgac tctgtcatcg actgtaatgt tgcagtctct cagattgttg     4740

acctcagcct agacccaacc ttcaccatca ccactcaaat cgtccctcag gacgctgtct     4800

cccgtagtca acgtagaggg agaactggga gggggcgatt gggcgtttac aggtatgttt     4860

cgtcaggcga aaggccgtct gggatgttcg acagcgtagt gctctgcgag tgctatgatg     4920

ccggggcagc ctggtacgag cttacacctg ctgagactac ggtgagactc cgggcttatt     4980

tcaacacgcc cggtttgccc gtatgtcaag accacctgga gttctgggaa gcggtcttta     5040

caggtctcac acacattgac gcccacttcc tctcccagac gaagcaagga ggagaaaact     5100

ttgcgtatct aacggcctac caggccacag tatgcgccag ggcaaaggcc cctcctcctt     5160

cgtgggacgt gatgtggaag tgtctaacta ggctcaaacc tacactgact ggtcccaccc     5220

ccctcctgta ccgcttgggt gccgtgacca atgaggtcac cttgacgcac cccgtgacga     5280

aatacatcgc cacgtgcatg caagctgacc tcgagatcat gacaagctca tgggtcctgg     5340

cggggggggt gctagccgcc gtggcatctt actgcctggc gactggctgc atttccatca     5400

ttggccgcct acacctgaat gatcgggtgg ttgtggcccc cgacaaggaa atcttatatg     5460

aggcctttga tgagatggaa gaatgcgcct ccaaagccgc cctcattgag gaagggcagc     5520

ggatggcgga gatgctcaaa tctaagatac aaggcctcct acaacaggcc acaaggcaag     5580

ctcaagacat acagccagct atacagtcat catggcccaa gcttgaacaa ttttgggcca     5640

aacacatgtg gaacttcatc agtggtatac agtacctagc aggactctcc accctaccgg     5700

gaaatcctgc agtagcatca atgatggctt ttagcgccgc gctgactagc ccactaccca     5760

ccagcaccac catcctcttg aacatcatgg gaggatggtt ggcctctcag attgcccccc     5820

ctgccggagc cactggcttc gttgtcagtg gtctagtggg ggcggccgtc ggaagcatag     5880

gcctgggtaa gatactggtg gacgttttgg ccgggtacgg cgcaggcatt tcaggggccc     5940

tcgtagcttt taagatcatg agcggcgaga agcccacggt agaagacgtt gtgaatctcc     6000

tgcctgctat tctgtctcct ggtgcgttgg tagtgggagt catctgtgca gcaatcctgc     6060

gccgccacgt cggtcaggga gagggggcgg tccagtggat gaacagactg atcgccttcg     6120

cctccagggg aaaccacgtt gcccctaccc actacgtggt ggagtctgac gcttcacagc     6180

gtgtaacgca ggtgctgagt tcacttacaa ttaccagctt acttaggaga ctacatgcct     6240

gggtcactga agattgccca gtcccatgct cggggtcttg gctccaggac atttgggatt     6300

gggtttgttc catcctcaca gacttcaaaa actggctgtc ttcaaaatta ctccccaaga     6360

tgcccggcat tccctttatc tcttgccaga agggatacaa gggtgtatgg gctggtacgg     6420

gtgtcatgac tactcggtgc ccatgtggag caaacatctc gggccatgtc cgcatgggca     6480

ccatgaaaat aacaggcccg aagacttgct tgaacctgtg gcaggggact ttccccatta     6540

attgttacac agaagggcct tgcgtgccaa aaccccctcc taattacaag accgcaattt     6600

ggagggtggc agcgtcggag tacgttgagg tcacacagca tggctctttc tcgtatgtaa     6660

cagggttaac cagtgacaac cttaaggtcc cttgccaggt accagctcca gaatttttct     6720

cttgggtgga cggggtgcaa atccaccgat tcgcccccgt tccaggtccc ttctttcggg     6780

atgaggtaac gttcaccgta ggccttaact ccttcgtggt cggctctcag ctcccttgcg     6840

atcctgagcc ggacaccgag gtactggcct ccatgttgac agacccgtcc cacatcaccg     6900

cggaggcggc agccaggcga ttggcaaggg gatctccccc ttcacaggct agctcctcag     6960

cgagccagct ctctgccccg tccttgaagg ctacctgtac cacccataag acagcatatg     7020

attgtgacat ggtggatgcc aaccttttca tgggaggcga tgtgacccgg attgagtctg     7080

actctaaggt gatcgttctc gactccctcg attccatgac tgaggtagag gatgatcgtg     7140

agccttctgt accatcagag tacctgatca agaggagaaa gttcccaccg gcgctgcctc     7200

cttgggcccg tccagactac aatcctgttt tgatcgagac atggaagagg ccgggctatg     7260

aaccacccac tgtcctaggc tgtgccctcc cccccacacc tcaaacgcca gtgcctccac     7320

ctcggaggcg ccgcgccaaa gtcctgaccc aggacaatgt ggaggggatc ctcagggaga     7380

tggctgacaa agtactcagc cctctccaag acaacaatga ctccggtcac tccactggag     7440

cggataccgg aggagacatc gtccagcaac cctctgacga gactgccgct tcagaagcgg     7500

ggtcactgtc ctccatgcct ccccttgagg gagagccggg agaccctgac ctggagtttg     7560

aaccagtggg atccgctccc ccttctgagg gggagtgtga ggtcattgat tcggactcta     7620

agtcgtggtc cacagtctct gatcaagagg attctgttat ctgctgctct atgtcatact     7680

cctggacggg ggccctcata acaccatgtg ggcccgaaga ggagaagtta ccgatcaacc     7740

ctctgagtaa ttcgctcatg cggttccata ataaggtgta ctccacaacc tcgaggagtg     7800

cctctctgag ggcaaagaag gtgacttttg acagggtgca ggtgctggac gcacactatg     7860

actcagtctt gcaggacgtt aagcgggccg cctctaaggt tagtgcgagg ctcctcacgg     7920

tagaggaagc ctgcgcgctg accccgcccc actccgccaa atcgcgatac ggatttgggg     7980

caaaagaggt gcgcagctta tccaggaggg ccgttaacca catccggtcc gtgtgggagg     8040

acctcctgga agaccaacat accccaattg acacaactat catggctaaa aatgaggtgt     8100

tctgcattga tccaactaaa ggtgggaaaa agccagctcg cctcatcgta taccccgacc     8160

ttggggtcag ggtgtgcgaa aagatggccc tctatgacat cgcacaaaag cttcccaaag     8220

cgataatggg gccatcctat gggttccaat actctcccgc agaacgggtc gatttcctcc     8280

tcaaagcttg gggaagtaag aaggacccaa tggggttctc gtatgacacc cgctgctttg     8340

actcaaccgt cacggagagg gacataagaa cagaagaatc catatatcag gcttgttctc     8400

tgcctcaaga agccagaact gtcatacact cgctcactga gagactttac gtaggagggc     8460

ccatgacaaa cagcaaaggg caatcctgcg gctacaggcg ttgccgcgca agcggtgttt     8520

tcaccaccag catggggaat accatgacat gttacatcaa agcccttgca gcgtgtaagg     8580

ctgcagggat cgtggaccct gttatgttgg tgtgtggaga cgacctggtc gtcatctcag     8640

agagccaagg taacgaggag gacgagcgaa acctgagagc tttcacggag gctatgacca     8700

ggtattccgc ccctcccggt gaccttccca gaccggaata tgacttggag cttataacat     8760

cctgctcctc aaacgtatcg gtagcgctgg actctcgggg tcgccgccgg tacttcctaa     8820

ccagagaccc taccactcca atcacccgag ctgcttggga aacagtaaga cactcccctg     8880

tcaattcttg gctgggcaac atcatccagt acgcccccac aatctgggtc cggatggtca     8940

taatgactca cttcttctcc atactattgg cccaggacac tctgaaccaa aatctcaatt     9000

ttgagatgta cggggcagta tactcggtca atccattaga cctaccggcc ataattgaaa     9060

ggctacatgg gcttgaagcc ttttcactgc acacatactc tccccgcgaa ctctcacggg     9120

tggcagcaac tctcagaaaa cttggagcgc ctccccttag agcgtggaag agtcgggcgc     9180

gtgccgtgag agcttcactc atcgcccaag gagcgagggc ggccatttgt ggccgctacc     9240

tcttcaactg ggcggtgaaa acaaagctca aactcactcc attgcccgag gcgagccgcc     9300

tggatttatc cgggtggttc accgtgggcg ccggcggggg cggcatttat cacagcgtgt     9360

cgcatgcccg accccgccta ttactccttt gcctactcct acttagcgta ggagtaggca     9420

tctttttact ccccgctcgg tagagcggca aaccctagct acactccata gctagtttcc     9480

gttttttttt ttttgttttt tttttttttt tttttttttt tttttttttt tttcttttcc     9540

tttttttttt ttctctttct tggtggctcc atcttagccc tagtcacggc tagctgtgaa     9600

aggtccgtga gccgcatgac tgcagagagt gccgtaactg gtctctctgc agatcatgt      9659


<210>  66
<211>  9659
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  66
gcccgccccc tgatgggggc gacactccgc catgaatcac tcccctgtga ggaactactg       60

tcttcacgca gaaagcgtct agccatggcg ttagtatgag tgtcgtacag cctccaggcc      120

cccccctccc gggagagcca tagtggtctg cggaaccggt gagtacaccg gaattaccgg      180

aaagactggg tcctttcttg gataaaccca ctctatgtcc ggtcatttgg gcacgccccc      240

gcaagactgc tagccgagta gcgttgggtt gcgaaaggcc ttgtggtact gcctgatagg      300

gtgcttgcga gtgccccggg aggtctcgta gaccgtgcat catgagcaca aatcctaaac      360

ctcaaagaaa aaccaaaaga aacacaaacc gccgcccaca ggacgttaag ttcccgggtg      420

gcggtcagat cgttggcgga gtttacttgc tgccgcgcag gggccccagg ttgggtgtgc      480

gcgcgacaag gaagacttct gagcgatccc agccgcgtgg acgacgccag cccatcccga      540

aagatcggcg ctccaccggc aagtcctggg gaaagccagg atatccttgg cccctgtacg      600

gaaacgaggg ttgcggctgg gcgggttggc tcctgtcccc ccgcgggtct cgtcctactt      660

ggggccccac cgacccccgg catagatcac gcaatttggg cagagtcatc gataccatta      720

cgtgtggttt tgccgacctc atggggtaca tccctgtcgt tggcgccccg gttggaggcg      780

tcgccagagc tctggcacac ggtgttaggg tcctggagga cgggataaat tacgcaacag      840

ggaatttacc cggttgctct ttttctatct ttttgcttgc tcttctgtca tgcgtcacag      900

tgccagtgtc tgcagtggaa gtcaggaaca ttagttctag ctactacgcc actaatgatt      960

gctcaaacaa cagcatcacc tggcagctca ctgacgcagt tctccatctt cctggatgcg     1020

tcccatgtga gaatgataat ggcaccttgc attgctggat acaagtaaca cccaacgtgg     1080

ctgtgaaaca ccgcggtgcg ctcactcgta gcctgcgaac acacgtcgac atgatcgtaa     1140

tggcagctac ggcctgctcg gccttgtatg tgggagatgt gtgcggggcc gtgatgattc     1200

tatcgcaggc tttcatggta tcaccacaac gccacaactt cacccaagag tgcaactgtt     1260

ccatctacca aggtcacatc accggccatc gcatggcatg ggacatgatg ctgaactggt     1320

ctccaactct tgccatgatc ctcgcctacg ccgctcgtgt tcccgagatg gtcctcgaaa     1380

ttattttcgg cggccattgg ggtgtggtgt ttggcttggc ctacttctcc atgcaaggag     1440

cgtgggccaa agtcattgcc atcctccttc ttgttgcggg agtggatgca accacctatt     1500

ccagcggcca ggaagcgggt cgtaccgtct tggggttcac taacctcttt acttctggtg     1560

ccaagcagaa cctctattta atcaacacca atggcagctg gcacataaac cggactgccc     1620

tcaattgcaa tgacagctta cagacgggtt tcatggcttc cctgttttac acccacaggt     1680

tcaacagctc tggctgcccc gagcgcttgt cttcctgccg cgggctggac gattttcgca     1740

tcggctgggg aaccttggaa tacgaaaccc acgtcaccaa cgatgaggac atgaggccgt     1800

actgctggca ttaccctccg aggccttgcg gcatcgtccc ggctagaacg gtttgcggac     1860

cggtctattg tttcacccct agccctgttg tcgtgggcac cactgacaag cagggcgtac     1920

ccacctacac ctggggggaa aacgagaccg atgtcttcct gctgaatagc acaagacccc     1980

cgcgaggagc ttggttcggc tgcacttgga tgaacgggac tgggttcact aagacatgcg     2040

gtgcaccacc ttgccgcatt aggaaagact acaacagcac tatcgattta ttgtgcccca     2100

cagactgttt taggaagcac cccgatgcta cctatcttaa gtgtggagca gggccttggt     2160

taactcccag gtgcctggta gactaccctt atagactgtg gcattatccg tgcactgtaa     2220

acttcaccat ctttaaggcg cggatgtatg taggaggggt ggagcatcga ttctccgcag     2280

catgcaactt cacgcgcgga gatcgctgca gactggaaga tagggatagg ggtcagcaga     2340

gtccactgct gcattccact actgagtggg cggtgctccc atgctccttc tctgacctac     2400

cagcactatc cactggccta ttgcacctcc accaaaacat cgtggacgtg cagtaccttt     2460

acggactttc tccggctctg acaagataca tcgtgaagtg ggagtgggtg atcctccttt     2520

tcttgttgtt ggcagacgcc aggatctgtg catgcctttg gatgctcatc atactgggcc     2580

aagccgaagc ggcgcttgag aagctcatca tcttgcactc cgctagtgct gctagtgcca     2640

atggtccgct gtggtgtttc atcttcttta cagcggcctg gtacttaaag ggcagggtgg     2700

tccccgtggc cacgtactct gttctcggct tatggtcctt cctcctccta gtcctggcct     2760

taccacagca ggcttatgcc ttggacgctg ctgaacaagg ggaactgggg ctggccatat     2820

tagtaattat atccatcttt actcttaccc cagcatacaa gatcctcctg agccgttcag     2880

tgtggtggct gtcctacatg ctggtcttgg ccgaggccca gattcagcaa cgggttcccc     2940

ccctggaggt ccgagggggg cgtgacggaa tcatctgggt ggctgtcatt ctacacccac     3000

gccttgtgtt tgaggtcacg aaatggttgt tagcaatcct ggggcctgcc tacctcctta     3060

aagcgtctct gctacggata ccgtactttg tgagggccca cgctttgcta cgagtgtgta     3120

ccctggtgaa acacctcgcg ggggctaggt acatccagat gctgttgatc accataggca     3180

gatggaccgg cacttacatc tacgaccacc tctccccttt atcaacttgg gcggcccagg     3240

gtttgcggga cctggcaatc gccgtggagc ctgtggtgtt cagcccaatg gagaagaagg     3300

tcattgtgtg gggggctgag acagtggcgt gtggagacat cctgcatggc ctcccggtct     3360

ccgcgaggct aggtagggag gttctgctcg gccctgccga cggctacacc tccaaggggt     3420

ggaagctcct agctcccatt actgcttaca ctcagcaaac tcgtggtctc ctgggtgcta     3480

tcgtggtcag cctaacgggc cgcgacaaaa atgagcaggc tgggcaggtc caggttctgt     3540

cctccgtcac acaaactttc ttggggacat ccatttcggg cgtcctctgg acagtatatc     3600

acggggctgg taataagacc ttggccggcc ccaagggacc agtcactcag atgtacacca     3660

gcgcagaagg ggacctcgtg ggatggccta gtccccccgg gactaagtca ttggacccct     3720

gtacctgcgg ggccgtagac ctctacctgg tcacccgaaa cgctgatgtc attccggtcc     3780

ggaggaaaga tgaccgacgg ggtgcattac tctcgccaag gcccctctca accctcaaag     3840

gatcatccgg agggcccgtg ctctgctcaa ggggacacgc cgtgggcttg ttcagagcgg     3900

ccgtgtgtgc caggggtgta gccaaatcta ttgacttcat ccccgtcgaa tcactcgatg     3960

tcaccacacg gacgcccagt ttctctgaca acagtacgcc gccagctgtg ccccagtctt     4020

accaggtggg ttacttgcac gcaccaacag gcagcggaaa gagcaccaag gtccctgccg     4080

cgtatgccag tcaggggtat aaagtactcg tactaaatcc ctctgtcgcg gccacacttg     4140

gttttggggc ctacatgtcc aaagcccacg ggatcaaccc taatatcaga actggagtgc     4200

ggaccgttgc caccggggac tctatcactt actccactta tggcaagttt atcgcagatg     4260

gaggctgtgc agccggtgcc tatgacatca tcatatgcga cgaatgccat tcagtggacg     4320

ctactaccat ccttggcatt ggaacagtcc ttgaccaagc tgagaccgca ggcgtcaggc     4380

tagtggtttt ggccacagcc acgcctcccg gtacggtgac aactccccac agtaacatag     4440

aggaggtggc ccttggtcac gagggcgaga tcccttttta tggcaaagcc attcccctag     4500

ctttcatcaa ggggggcaga cacttgatct tttgccattc aaagaagaag tgcgacgagc     4560

tcgcagcggc cctccggggc atgggtgtca atgccgttgc atactatagg ggtctcgacg     4620

tctccgttat accaactcaa ggagacgtgg tggttgtcgc cactgatgcc ctaatgactg     4680

ggtacaccgg cgactttgac tctgtcatcg actgtaatgt tgcagtctct cagattgttg     4740

acctcagcct agacccaacc ttcaccatca ccactcaaat cgtccctcag gacgctgtct     4800

cccgtagtca acgtagaggg agaactggga gggggcgatt gggcgtttac aggtatgttt     4860

cgtcaggcga aaggccgtct gggatgttcg acagcgtagt gctctgcgag tgctatgatg     4920

ccggggcagc ctggtacgag cttacacctg ctgagactac ggtgagactc cgggcttatt     4980

tcaacacgcc cggtttgccc gtatgtcaag accacctgga gttctgggaa gcggtcttta     5040

caggtctcac acacattgac gcccacttcc tctcccagac gaagcaagga ggagaaaact     5100

ttgcgtatct aacggcctac caggccacag tatgcgccag ggcaaaggcc cctcctcctt     5160

cgtgggacgt gatgtggaag tgtctaacta ggctcaaacc tacactgact ggtcccaccc     5220

ccctcctgta ccgcttgggt gccgtgacca atgaggtcac cttgacgcac cccgtgacga     5280

aatacatcgc cacgtgcatg caagctgacc tcgagatcat gacaagctca tgggtcctgg     5340

cggggggggt gctagccgcc gtggcatctt actgcctggc gactggctgc atttccatca     5400

ttggccgcct acacctgaat gatcgggtgg ttgtggcccc cgacaaggaa atcttatatg     5460

aggcctttga tgagatggaa gaatgcgcct ccaaagccgc cctcattgag gaagggcagc     5520

ggatggcgga gatgctcaaa tctaagatac aaggcctcct acaacaggcc acaaggcaag     5580

ctcaagacat acagccagct atacagtcat catggcccaa gcttgaacaa ttttgggcca     5640

aacacatgtg gaacttcatc agtggtatac agtacctagc aggactctcc accctaccgg     5700

gaaatcctgc agtagcatca atgatggctt ttagcgccgc gctgactagc ccactaccca     5760

ccagcaccac catcctcttg aacatcatgg gaggatggtt ggcctctcag attgcccccc     5820

ctgccggagc cactggcttc gttgtcagtg gtctagtggg ggcggccgtc ggaagcatag     5880

gcctgggtaa gatactggtg gacgttttgg ccgggtacgg cgcaggcatt tcaggggccc     5940

tcgtagcttt taagatcatg agcggcgaga agcccacggt agaagacgtt gtgaatctcc     6000

tgcctgctat tctgtctcct ggtgcgttgg tagtgggagt catctgtgca gcaatcctgc     6060

gccgccacgt cggtcaggga gagggggcgg tccagtggat gaacagactg atcgccttcg     6120

cctccagggg aaaccacgtt gcccctaccc actacgtggt ggagtctgac gcttcacagc     6180

gtgtaacgca ggtgctgagt tcacttacaa ttaccagctt acttaggaga ctacatgcct     6240

gggtcactga agattgccca gtcccatgct cggggtcttg gctccaggac atttgggatt     6300

gggtttgttc catcctcaca gacttcaaaa actggctgtc ttcaaaatta ctccccaaga     6360

tgcccggcat tccctttatc tcttgccaga agggatacaa gggtgtatgg gctggtacgg     6420

gtgtcatgac tactcggtgc ccatgtggag caaacatctc gggccatgtc cgcatgggca     6480

ccatgaaaat aacaggcccg aagacttgct tgaacctgtg gcaggggact ttccccatta     6540

attgttacac agaagggcct tgcgtgccaa aaccccctcc taattacaag accgcaattt     6600

ggagggtggc agcgtcggag tacgttgagg tcacacagca tggctctttc tcgtatgtaa     6660

cagggttaac cagtgacaac cttaaggtcc cttgccaggt accagctcca gaatttttct     6720

cttgggtgga cggggtgcaa atccaccgat tcgcccccgt tccaggtccc ttctttcggg     6780

atgaggtaac gttcaccgta ggccttaact ccttcgtggt cggctctcag ctcccttgcg     6840

atcctgagcc ggacaccgag gtactggcct ccatgttgac agacccgtcc cacatcaccg     6900

cggaggcggc agccaggcga ttggcaaggg gatctccccc ttcacaggct agctcctcag     6960

cgagccagct ctctgccccg tccttgaagg ctacctgtac cacccataag acagcatatg     7020

attgtgacat ggtggatgcc aaccttttca tgggaggcga tgtgacccgg attgagtctg     7080

actctaaggt gatcgttctc gactccctcg attccatgac tgaggtagtg gatgatcgtg     7140

agccttctgt accatcagag tacctgatca agaggagaaa gttcccaccg gcgctgcctc     7200

cttgggcccg tccagactac aatcctgttt tgatcgagac atggaagagg ccgggctatg     7260

aaccacccac tgtcctaggc tgtgccctcc cccccacacc tcaaacgcca gtgcctccac     7320

ctcggaggcg ccgcgccaaa gtcctgaccc aggacaatgt ggaggggatc ctcagggaga     7380

tggctgacaa agtactcagc cctctccaag acaacaatga ctccggtcac tccactggag     7440

cggataccgg aggagacatc gtccagcaac cctctgacga gactgccgct tcagaagcgg     7500

ggtcactgtc ctccatgcct ccccttgagg gagagccggg agaccctgac ctggagtttg     7560

aaccagtggg atccgctccc ccttctgagg gggagtgtga ggtcattgat tcggactcta     7620

agtcgtggtc cacagtctct gatcaagagg attctgttat ctgctgctct atgtcatact     7680

cctggacggg ggccctcata acaccatgtg ggcccgaaga ggagaagtta ccgatcaacc     7740

ctctgagtaa ttcgctcatg cggttccata ataaggtgta ctccacaacc tcgaggagtg     7800

cctctctgag ggcaaagaag gtgacttttg acagggtgca ggtgctggac gcacactatg     7860

actcagtctt gcaggacgtt aagcgggccg cctctaaggt tagtgcgagg ctcctcacgg     7920

tagaggaagc ctgcgcgctg accccgcccc actccgccaa atcgcgatac ggatttgggg     7980

caaaagaggt gcgcagctta tccaggaggg ccgttaacca catccggtcc gtgtgggagg     8040

acctcctgga agaccaacat accccaattg acacaactat catggctaaa aatgaggtgt     8100

tctgcattga tccaactaaa ggtgggaaaa agccagctcg cctcatcgta taccccgacc     8160

ttggggtcag ggtgtgcgaa aagatggccc tctatgacat cgcacaaaag cttcccaaag     8220

cgataatggg gccatcctat gggttccaat actctcccgc agaacgggtc gatttcctcc     8280

tcaaagcttg gggaagtaag aaggacccaa tggggttctc gtatgacacc cgctgctttg     8340

actcaaccgt cacggagagg gacataagaa cagaagaatc catatatcag gcttgttctc     8400

tgcctcaaga agccagaact gtcatacact cgctcactga gagactttac gtaggagggc     8460

ccatgacaaa cagcaaaggg caatcctgcg gctacaggcg ttgccgcgca agcggtgttt     8520

tcaccaccag catggggaat accatgacat gttacatcaa agcccttgca gcgtgtaagg     8580

ctgcagggat cgtggaccct gttatgttgg tgtgtggaga cgacctggtc gtcatctcag     8640

agagccaagg taacgaggag gacgagcgaa acctgagagc tttcacggag gctatgacca     8700

ggtattccgc ccctcccggt gaccttccca gaccggaata tgacttggag cttataacat     8760

cctgctcctc aaacgtatcg gtagcgctgg actctcgggg tcgccgccgg tacttcctaa     8820

ccagagaccc taccactcca atcacccgag ctgcttggga aacagtaaga cactcccctg     8880

tcaattcttg gctgggcaac atcatccagt acgcccccac aatctgggtc cggatggtca     8940

taatgactca cttcttctcc atactattgg cccaggacac tctgaaccaa aatctcaatt     9000

ttgagatgta cggggcagta tactcggtca gtccattaga cctaccggcc ataattgaaa     9060

ggctacatgg gcttgaagcc ttttcactgc acacatactc tccccgcgaa ctctcacggg     9120

tggcagcaac tctcagaaaa cttggagcgc ctccccttag agcgtggaag agtcgggcgc     9180

gtgccgtgag agcttcactc atcgcccaag gagcgagggc ggccatttgt ggccgctacc     9240

tcttcaactg ggcggtgaaa acaaagctca aactcactcc attgcccgag gcgagccgcc     9300

tggatttatc cgggtggttc accgtgggcg ccggcggggg cggcatttat cacagcgtgt     9360

cgcatgcccg accccgccta ttactccttt gcctactcct acttagcgta ggagtaggca     9420

tctttttact ccccgctcgg tagagcggca aaccctagct acactccata gctagtttcc     9480

gttttttttt ttttgttttt tttttttttt tttttttttt tttttttttt tttcttttcc     9540

tttttttttt ttctctttct tggtggctcc atcttagccc tagtcacggc tagctgtgaa     9600

aggtccgtga gccgcatgac tgcagagagt gccgtaactg gtctctctgc agatcatgt      9659


<210>  67
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  67

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala 
            180                 185                 190         


Glu Val Lys Asn Ile Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Thr 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Val Gly Asn Ala Ser Gln Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Arg 
    370                 375                 380                 


Thr His Thr Val Gly Gly Ser Ala Ala Gln Thr Thr Gly Arg Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Asp Met Gly Pro Arg Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr His Ser Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ser Ala Cys Arg Ser Ile Glu Ala 
    450                 455                 460                 


Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Gln Cys 
                485                 490                 495     


Gly Val Val Ser Ala Lys Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Leu Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Ser 
545                 550                 555                 560 


Gly Tyr Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Phe Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Val Ile Leu His Ala Ala Ser Ala Ala Ser Cys Asn Gly 
        755                 760                 765             


Phe Leu Tyr Phe Val Ile Phe Phe Val Ala Ala Trp Tyr Ile Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Ala Thr Tyr Ser Leu Thr Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Ser Leu Leu Leu Leu Ala Leu Pro Gln Gln Ala Tyr Ala Tyr Asp Ala 
                805                 810                 815     


Ser Val His Gly Gln Ile Gly Ala Ala Leu Leu Val Met Ile Thr Leu 
            820                 825                 830         


Phe Thr Leu Thr Pro Gly Tyr Lys Thr Leu Leu Ser Arg Phe Leu Trp 
        835                 840                 845             


Trp Leu Cys Tyr Leu Leu Thr Leu Gly Glu Ala Met Val Gln Glu Trp 
    850                 855                 860                 


Ala Pro Pro Met Gln Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Ala 
865                 870                 875                 880 


Val Ala Ile Phe Tyr Pro Gly Val Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Val Leu Gly Pro Ala Tyr Leu Leu Lys Gly Ala Leu Thr Arg 
            900                 905                 910         


Val Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Met Cys Thr Met 
        915                 920                 925             


Ala Arg His Leu Ala Gly Gly Arg Tyr Val Gln Met Ala Leu Leu Ala 
    930                 935                 940                 


Leu Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Thr Pro Met 
945                 950                 955                 960 


Ser Asp Trp Ala Ala Ser Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Ile Ile Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Ala Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Ser Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Ala Ile Val Val Ser  Met Thr Gly 
    1040                 1045                 1050             


Arg Asp  Arg Thr Glu Gln Ala  Gly Glu Val Gln Ile  Leu Ser Thr 
    1055                 1060                 1065             


Val Ser  Gln Ser Phe Leu Gly  Thr Thr Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Leu Arg 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Ser Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Glu  Pro Cys Lys 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Ala Arg Arg Arg Gly  Asp Lys Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Ile Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Arg Gly His Val  Val Gly Leu Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ser  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Thr Leu  Asp Val Val Thr Arg  Ser Pro Thr Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Val Ala Tyr 
    1235                 1240                 1245             


Ala Ala  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Leu Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Met  Thr Gly Glu 
    1280                 1285                 1290             


Ala Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Ser Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Val  Asp Ala Thr Ser Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Thr Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Thr Pro His Pro Asp  Ile Glu Glu 
    1355                 1360                 1365             


Val Gly  Leu Gly Arg Glu Gly  Glu Ile Pro Phe Tyr  Gly Arg Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ser Cys Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Leu Asn Ala Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Ile Ile  Pro Ala Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Ala  Val Asp Phe Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Thr  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Gln  Gly Thr Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Thr Gly Glu  Arg Ala Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Asp 
    1520                 1525                 1530             


Leu Thr  Pro Ala Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Ala Gly Glu  Asn Phe Ala Tyr Leu  Val Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Ala  Met Trp Lys Cys Leu  Ala Arg Leu Lys Pro  Thr Leu Ala 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Pro Ile  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Gly  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Val Met  Thr Ser Thr Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ala Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Val Ser  Ile Ile Gly Arg Leu  His Val Asn Gln Arg  Val Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Val Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Arg Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Ile 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Ser Lys  Gln Ala Gln Asp Ile  Gln Pro Ala Met Gln  Ala Ser Trp 
    1745                 1750                 1755             


Pro Lys  Val Glu Gln Phe Trp  Ala Arg His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ser Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Met Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Ile  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Ser Met  Glu Asp Val Ile Asn  Leu Leu Pro Gly Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Pro Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Thr  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Leu Leu Gly 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Asn Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Ile Pro  Cys Gly Gly Ser Trp  Leu Arg Asp 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Thr  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Thr  Ser Lys Leu Phe Pro  Lys Met Pro Gly Leu  Pro Phe Val 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Ile 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly Asn Val 
    2030                 2035                 2040             


Arg Leu  Gly Ser Met Arg Ile  Thr Gly Pro Lys Thr  Cys Met Asn 
    2045                 2050                 2055             


Ile Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Gln 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Ala Pro  Asn Phe Lys Val Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Ala  Glu Val Thr Gln His  Gly Ser Tyr 
    2090                 2095                 2100             


His Tyr  Ile Thr Gly Leu Thr  Thr Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Leu  Pro Ser Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Thr  Pro Lys Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Ser  Phe Cys Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Asp Val Leu  Met Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Glu Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Arg Ala Thr Cys Thr  Thr His Gly 
    2210                 2215                 2220             


Lys Ala  Tyr Asp Val Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Gly Ser Lys Val  Val Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Pro Met Val  Glu Glu Arg Ser Asp  Leu Glu Pro 
    2255                 2260                 2265             


Ser Ile  Pro Ser Glu Tyr Met  Leu Pro Lys Lys Arg  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ala Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Ser  Trp Lys Arg Pro Asp  Tyr Gln Pro Ala Thr  Val Ala Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Pro Arg  Lys Thr Pro Thr Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Thr Val Gly Leu  Ser Glu Asp Ser Ile  Gly Asp Ala 
    2330                 2335                 2340             


Leu Gln  Gln Leu Ala Ile Lys  Ser Phe Gly Gln Pro  Pro Pro Ser 
    2345                 2350                 2355             


Gly Asp  Ser Gly Leu Ser Thr  Gly Ala Gly Ala Ala  Asp Ser Gly 
    2360                 2365                 2370             


Ser Gln  Thr Pro Pro Asp Glu  Leu Ala Leu Ser Glu  Thr Gly Ser 
    2375                 2380                 2385             


Ile Ser  Ser Met Pro Pro Leu  Glu Gly Glu Leu Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Pro Glu Gln Val Glu  Pro Gln Pro Pro Pro  Gln Gly Gly 
    2405                 2410                 2415             


Val Ala  Ala Pro Gly Ser Asp  Ser Gly Ser Trp Ser  Thr Cys Ser 
    2420                 2425                 2430             


Glu Glu  Asp Asp Ser Val Val  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Ser Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Leu Arg Tyr  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Cys Thr Thr Thr Lys  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Met Gln  Val Leu Asp Ser Tyr  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Lys Asp Ile Lys Leu  Ala Ala Ser Lys Val  Thr Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Met Glu Glu Ala  Cys Gln Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Arg  Ser Lys Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Gly  Arg Ala Val Asn His  Ile Lys Ser Val Trp  Lys Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Ser Glu Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Val Asp  Pro Thr Lys Gly Gly  Lys Lys Ala 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Thr Gln Lys Leu Pro  Gln Ala Val 
    2615                 2620                 2625             


Met Gly  Ala Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Gln Arg Val 
    2630                 2635                 2640             


Glu Tyr  Leu Leu Lys Ala Trp  Ala Glu Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Gln Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Glu Glu  Ala Arg Thr Ala Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Phe Asn  Ser Lys Gly Gln Thr  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Ile  Thr Cys Tyr Val Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Val Ala Pro Thr Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Thr Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Pro  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Gly Pro Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro Leu Ala  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Ile Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Leu Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Met Val Gln Asp Thr  Leu Asp Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ser Val Tyr Ser  Val Asn Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Asp Ala 
    2900                 2905                 2910             


Phe Ser  Met His Thr Tyr Ser  His His Glu Leu Thr  Arg Val Ala 
    2915                 2920                 2925             


Ser Ala  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Val Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ser  Arg Gly Gly 
    2945                 2950                 2955             


Lys Ala  Ala Val Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Arg  Leu Leu Asp 
    2975                 2980                 2985             


Leu Ser  Ser Trp Phe Thr Val  Gly Ala Gly Gly Gly  Asp Ile Phe 
    2990                 2995                 3000             


His Ser  Val Ser Arg Ala Arg  Pro Arg Ser Leu Leu  Phe Gly Leu 
    3005                 3010                 3015             


Leu Leu  Leu Phe Val Gly Val  Gly Leu Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  68
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  68

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala 
            180                 185                 190         


Glu Val Lys Asn Ile Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Thr 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Val Gly Asn Ala Ser Gln Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Arg 
    370                 375                 380                 


Thr His Thr Val Gly Gly Ser Ala Ala Gln Thr Thr Gly Arg Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Asp Met Gly Pro Arg Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr His Ser Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ser Ala Cys Arg Ser Ile Glu Ala 
    450                 455                 460                 


Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Gln Cys 
                485                 490                 495     


Gly Val Val Ser Ala Lys Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Leu Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Ser 
545                 550                 555                 560 


Gly Tyr Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Phe Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Val Ile Leu His Ala Ala Ser Ala Ala Ser Cys Asn Gly 
        755                 760                 765             


Phe Leu Tyr Phe Val Ile Phe Phe Val Ala Ala Trp Tyr Ile Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Ala Thr Tyr Ser Leu Thr Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Ser Leu Leu Leu Leu Ala Leu Pro Gln Gln Ala Tyr Ala Tyr Asp Ala 
                805                 810                 815     


Ser Val His Gly Gln Ile Gly Ala Ala Leu Leu Val Met Ile Thr Leu 
            820                 825                 830         


Phe Thr Leu Thr Pro Gly Tyr Lys Thr Leu Leu Ser Arg Phe Leu Trp 
        835                 840                 845             


Trp Leu Cys Tyr Leu Leu Thr Leu Gly Glu Ala Met Val Gln Glu Trp 
    850                 855                 860                 


Ala Pro Pro Met Gln Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Ala 
865                 870                 875                 880 


Val Ala Ile Phe Tyr Pro Gly Val Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Val Leu Gly Pro Ala Tyr Leu Leu Lys Gly Ala Leu Thr Arg 
            900                 905                 910         


Val Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Met Cys Thr Met 
        915                 920                 925             


Ala Arg His Leu Ala Gly Gly Arg Tyr Val Gln Met Ala Leu Leu Ala 
    930                 935                 940                 


Leu Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Thr Pro Met 
945                 950                 955                 960 


Ser Asp Trp Ala Ala Ser Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Ile Ile Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Ala Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Ser Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Ala Ile Val Val Ser  Met Thr Gly 
    1040                 1045                 1050             


Arg Asp  Arg Thr Glu Gln Ala  Gly Glu Val Gln Ile  Leu Ser Thr 
    1055                 1060                 1065             


Val Ser  Gln Ser Phe Leu Gly  Thr Thr Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Leu Arg 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Ser Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Glu  Pro Cys Lys 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Ala Arg Arg Arg Gly  Asp Lys Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Ile Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Arg Gly His Val  Val Gly Leu Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ser  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Thr Leu  Asp Val Val Thr Arg  Ser Pro Thr Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Val Ala Tyr 
    1235                 1240                 1245             


Ala Ala  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Leu Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Met  Thr Gly Glu 
    1280                 1285                 1290             


Ala Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Ser Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Val  Asp Ala Thr Ser Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Thr Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Thr Pro His Pro Asp  Ile Glu Glu 
    1355                 1360                 1365             


Val Gly  Leu Gly Arg Glu Gly  Glu Ile Pro Phe Tyr  Gly Arg Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ser Cys Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Leu Asn Ala Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Ile Ile  Pro Ala Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Ala  Val Asp Phe Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Thr  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Gln  Gly Thr Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Thr Gly Glu  Arg Ala Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Asp 
    1520                 1525                 1530             


Leu Thr  Pro Ala Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Ala Gly Glu  Asn Phe Ala Tyr Leu  Val Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Ala  Met Trp Lys Cys Leu  Ala Arg Leu Lys Pro  Thr Leu Ala 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Pro Ile  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Gly  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Val Met  Thr Ser Thr Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ala Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Val Ser  Ile Ile Gly Arg Leu  His Val Asn Gln Arg  Val Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Val Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Arg Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Ile 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Ser Lys  Gln Ala Gln Asp Ile  Gln Pro Ala Met Gln  Ala Ser Trp 
    1745                 1750                 1755             


Pro Lys  Val Glu Gln Phe Trp  Ala Arg His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ser Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Met Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Ile  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Ser Met  Glu Asp Val Ile Asn  Leu Leu Pro Gly Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Pro Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Thr  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Leu Leu Gly 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Asn Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Ile Pro  Cys Gly Gly Ser Trp  Leu Arg Asp 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Thr  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Thr  Ser Lys Leu Phe Pro  Lys Met Pro Gly Leu  Pro Phe Val 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Ile 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly Asn Val 
    2030                 2035                 2040             


Arg Leu  Gly Ser Met Arg Ile  Thr Gly Pro Lys Thr  Cys Met Asn 
    2045                 2050                 2055             


Ile Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Gln 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Ala Pro  Asn Phe Lys Val Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Ala  Glu Val Thr Gln His  Gly Ser Tyr 
    2090                 2095                 2100             


His Tyr  Ile Thr Gly Leu Thr  Thr Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Leu  Pro Ser Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Thr  Pro Lys Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Ser  Phe Cys Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Asp Val Leu  Met Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Glu Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Arg Ala Thr Cys Thr  Thr His Gly 
    2210                 2215                 2220             


Lys Ala  Tyr Asp Val Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Gly Ser Lys Val  Val Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Pro Met Val  Glu Glu Arg Ser Asp  Leu Glu Pro 
    2255                 2260                 2265             


Ser Ile  Pro Ser Glu Tyr Met  Leu Pro Lys Lys Arg  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ala Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Ser  Trp Lys Arg Pro Asp  Tyr Gln Pro Ala Thr  Val Ala Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Pro Arg  Lys Thr Pro Thr Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Thr Val Gly Leu  Ser Glu Asp Ser Ile  Gly Asp Ala 
    2330                 2335                 2340             


Leu Gln  Gln Leu Ala Ile Lys  Ser Phe Gly Gln Pro  Pro Pro Ser 
    2345                 2350                 2355             


Gly Asp  Ser Gly Leu Ser Thr  Gly Ala Gly Ala Ala  Asp Ser Gly 
    2360                 2365                 2370             


Ser Gln  Thr Pro Pro Asp Glu  Leu Ala Leu Ser Glu  Thr Gly Ser 
    2375                 2380                 2385             


Ile Ser  Ser Met Pro Pro Leu  Glu Gly Glu Leu Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Pro Glu Gln Val Glu  Pro Gln Pro Pro Pro  Gln Gly Gly 
    2405                 2410                 2415             


Val Ala  Ala Pro Gly Ser Asp  Ser Gly Ser Trp Ser  Thr Cys Ser 
    2420                 2425                 2430             


Glu Glu  Asp Asp Ser Val Val  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Ser Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Leu Arg Tyr  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Cys Thr Thr Thr Lys  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Met Gln  Val Leu Asp Ser Tyr  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Lys Asp Ile Lys Leu  Ala Ala Ser Lys Val  Thr Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Met Glu Glu Ala  Cys Gln Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Arg  Ser Lys Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Gly  Arg Ala Val Asn His  Ile Lys Ser Val Trp  Lys Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Ser Glu Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Val Asp  Pro Thr Lys Gly Gly  Lys Lys Ala 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Thr Gln Lys Leu Pro  Gln Ala Val 
    2615                 2620                 2625             


Met Gly  Ala Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Gln Arg Val 
    2630                 2635                 2640             


Glu Phe  Leu Leu Lys Ala Trp  Ala Glu Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Arg Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Glu Glu  Ala His Thr Ala Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Phe Asn  Ser Lys Gly Gln Thr  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Ile  Thr Cys Tyr Val Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Ile Ala Pro Thr Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Thr Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Pro  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Gly Pro Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro Leu Ala  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Ile Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Leu Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Met Val Gln Asp Thr  Leu Asp Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ser Val Tyr Ser  Val Asn Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Asp Ala 
    2900                 2905                 2910             


Phe Ser  Met His Thr Tyr Ser  His His Glu Leu Thr  Arg Val Ala 
    2915                 2920                 2925             


Ser Ala  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Val Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ser  Arg Gly Gly 
    2945                 2950                 2955             


Lys Ala  Ala Val Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Arg  Leu Leu Asp 
    2975                 2980                 2985             


Leu Ser  Ser Trp Phe Thr Val  Gly Ala Gly Gly Gly  Asp Ile Phe 
    2990                 2995                 3000             


His Ser  Val Ser Arg Ala Arg  Pro Arg Ser Leu Leu  Phe Gly Leu 
    3005                 3010                 3015             


Leu Leu  Leu Phe Val Gly Val  Gly Leu Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  69
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  69

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala 
            180                 185                 190         


Glu Val Lys Asn Ile Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Thr 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Val Gly Asn Ala Ser Gln Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Arg 
    370                 375                 380                 


Thr His Thr Val Gly Gly Ser Ala Ala Gln Thr Thr Gly Arg Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Asp Met Gly Pro Arg Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr His Ser Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ser Ala Cys Arg Ser Ile Glu Ala 
    450                 455                 460                 


Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Gln Cys 
                485                 490                 495     


Gly Val Val Ser Ala Lys Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Leu Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Ser 
545                 550                 555                 560 


Gly Tyr Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Phe Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Val Ile Leu His Ala Ala Ser Ala Ala Ser Cys Asn Gly 
        755                 760                 765             


Phe Leu Tyr Phe Val Ile Phe Phe Val Ala Ala Trp Tyr Ile Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Ala Thr Tyr Ser Leu Thr Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Ser Leu Leu Leu Leu Ala Leu Pro Gln Gln Ala Tyr Ala Tyr Asp Ala 
                805                 810                 815     


Ser Val His Gly Gln Ile Gly Ala Ala Leu Leu Val Met Ile Thr Leu 
            820                 825                 830         


Phe Thr Leu Thr Pro Gly Tyr Lys Thr Leu Leu Ser Arg Phe Leu Trp 
        835                 840                 845             


Trp Leu Cys Tyr Leu Leu Thr Leu Gly Glu Ala Met Val Gln Glu Trp 
    850                 855                 860                 


Ala Pro Pro Met Gln Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Ala 
865                 870                 875                 880 


Val Ala Ile Phe Tyr Pro Gly Val Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Val Leu Gly Pro Ala Tyr Leu Leu Lys Gly Ala Leu Thr Arg 
            900                 905                 910         


Val Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Met Cys Thr Met 
        915                 920                 925             


Ala Arg His Leu Ala Gly Gly Arg Tyr Val Gln Met Ala Leu Leu Ala 
    930                 935                 940                 


Leu Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Thr Pro Met 
945                 950                 955                 960 


Ser Asp Trp Ala Ala Ser Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Ile Ile Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Ala Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Ser Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Ala Ile Val Val Ser  Met Thr Gly 
    1040                 1045                 1050             


Arg Asp  Arg Thr Glu Gln Ala  Gly Glu Val Gln Ile  Leu Ser Thr 
    1055                 1060                 1065             


Val Ser  Gln Ser Phe Leu Gly  Thr Thr Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Leu Arg 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Ser Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Glu  Pro Cys Lys 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Ala Arg Arg Arg Gly  Asp Lys Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Ile Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Arg Gly His Val  Val Gly Leu Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ser  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Thr Leu  Asp Val Val Thr Arg  Ser Pro Thr Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Val Ala Tyr 
    1235                 1240                 1245             


Ala Ala  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Leu Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Met  Thr Gly Glu 
    1280                 1285                 1290             


Ala Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Ser Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Val  Asp Ala Thr Ser Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Thr Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Thr Pro His Pro Asp  Ile Glu Glu 
    1355                 1360                 1365             


Val Gly  Leu Gly Arg Glu Gly  Glu Ile Pro Phe Tyr  Gly Arg Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ser Cys Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Leu Asn Ala Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Ile Ile  Pro Ala Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Ala  Val Asp Phe Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Thr  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Gln  Gly Thr Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Thr Gly Glu  Arg Ala Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Asp 
    1520                 1525                 1530             


Leu Thr  Pro Ala Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Ala Gly Glu  Asn Phe Ala Tyr Leu  Val Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Ala  Met Trp Lys Cys Leu  Ala Arg Leu Lys Pro  Thr Leu Ala 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Pro Ile  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Gly  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Val Met  Thr Ser Thr Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ala Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Val Ser  Ile Ile Gly Arg Leu  His Val Asn Gln Arg  Val Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Val Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Arg Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Ile 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Ser Lys  Gln Ala Gln Asp Ile  Gln Pro Ala Met Gln  Ala Ser Trp 
    1745                 1750                 1755             


Pro Lys  Val Glu Gln Phe Trp  Ala Arg His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ser Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Met Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Ile  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Ser Met  Glu Asp Val Ile Asn  Leu Leu Pro Gly Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Pro Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Thr  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Leu Leu Gly 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Asn Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Ile Pro  Cys Gly Gly Ser Trp  Leu Arg Asp 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Thr  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Thr  Ser Lys Leu Phe Pro  Lys Met Pro Gly Leu  Pro Phe Val 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Ile 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly Asn Val 
    2030                 2035                 2040             


Arg Leu  Gly Ser Met Arg Ile  Thr Gly Pro Lys Thr  Cys Met Asn 
    2045                 2050                 2055             


Ile Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Gln 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Ala Pro  Asn Phe Lys Val Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Ala  Glu Val Thr Gln His  Gly Ser Tyr 
    2090                 2095                 2100             


His Tyr  Ile Thr Gly Leu Thr  Thr Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Leu  Pro Ser Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Thr  Pro Lys Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Ser  Phe Cys Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Asp Val Leu  Met Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Glu Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Arg Ala Thr Cys Thr  Thr His Gly 
    2210                 2215                 2220             


Lys Ala  Tyr Asp Val Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Gly Ser Lys Val  Val Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Pro Met Val  Glu Glu Arg Ser Asp  Leu Glu Pro 
    2255                 2260                 2265             


Ser Ile  Pro Ser Glu Tyr Met  Leu Pro Lys Lys Arg  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ala Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Ser  Trp Lys Arg Pro Asp  Tyr Gln Pro Ala Thr  Val Ala Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Pro Arg  Lys Thr Pro Thr Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Thr Val Gly Leu  Ser Glu Asp Ser Ile  Gly Asp Ala 
    2330                 2335                 2340             


Leu Gln  Gln Leu Ala Ile Lys  Ser Phe Gly Gln Pro  Pro Pro Ser 
    2345                 2350                 2355             


Gly Asp  Ser Gly Leu Ser Thr  Gly Ala Gly Ala Ala  Asp Ser Gly 
    2360                 2365                 2370             


Ser Gln  Thr Pro Pro Asp Glu  Leu Ala Leu Ser Glu  Thr Gly Ser 
    2375                 2380                 2385             


Ile Ser  Ser Met Pro Pro Leu  Glu Gly Glu Leu Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Pro Glu Gln Val Glu  Pro Gln Pro Pro Pro  Gln Gly Gly 
    2405                 2410                 2415             


Val Ala  Ala Pro Gly Ser Asp  Ser Gly Ser Trp Ser  Thr Cys Ser 
    2420                 2425                 2430             


Glu Glu  Asp Asp Ser Val Val  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Ser Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Leu Arg Tyr  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Cys Thr Thr Thr Lys  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Met Gln  Val Leu Asp Ser Tyr  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Lys Asp Ile Lys Leu  Ala Ala Ser Lys Val  Thr Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Met Glu Glu Ala  Cys Gln Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Arg  Ser Lys Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Gly  Arg Ala Val Asn His  Ile Lys Ser Val Trp  Lys Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Ser Glu Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Val Asp  Pro Thr Lys Gly Gly  Lys Lys Ala 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Thr Gln Lys Leu Pro  Gln Ala Val 
    2615                 2620                 2625             


Met Gly  Ala Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Gln Arg Val 
    2630                 2635                 2640             


Glu Phe  Leu Leu Lys Ala Trp  Ala Glu Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Arg Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Glu Glu  Ala His Thr Ala Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Phe Asn  Ser Lys Gly Gln Thr  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Ile  Thr Cys Tyr Val Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Ile Ala Pro Thr Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Thr Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Pro  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Gly Pro Gln Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Ala  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Ala Arg Met  Val Leu Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Met Val Gln Asp Thr  Leu Asp Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ser Val Tyr Ser  Val Asn Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Asp Ala 
    2900                 2905                 2910             


Phe Ser  Met His Thr Tyr Ser  His His Glu Leu Thr  Arg Val Ala 
    2915                 2920                 2925             


Ser Ala  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Val Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ser  Arg Gly Gly 
    2945                 2950                 2955             


Lys Ala  Ala Val Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Arg  Leu Leu Asp 
    2975                 2980                 2985             


Leu Ser  Ser Trp Phe Thr Val  Gly Ala Gly Gly Gly  Asp Ile Phe 
    2990                 2995                 3000             


His Ser  Val Ser Arg Ala Arg  Pro Arg Ser Leu Leu  Phe Gly Leu 
    3005                 3010                 3015             


Leu Leu  Leu Phe Val Gly Val  Gly Leu Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  70
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  70

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala 
            180                 185                 190         


Glu Val Lys Asn Ile Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Thr 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Val Gly Asn Ala Ser Gln Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Arg 
    370                 375                 380                 


Thr His Thr Val Gly Gly Ser Ala Ala Gln Thr Thr Gly Arg Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Asp Met Gly Pro Arg Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr His Ser Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ser Ala Cys Arg Ser Ile Glu Ala 
    450                 455                 460                 


Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Gln Cys 
                485                 490                 495     


Gly Val Val Ser Ala Lys Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Leu Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Ser 
545                 550                 555                 560 


Gly Tyr Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Phe Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Val Ile Leu His Ala Ala Ser Ala Ala Ser Cys Asn Gly 
        755                 760                 765             


Phe Leu Tyr Phe Val Ile Phe Phe Val Ala Ala Trp Tyr Ile Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Ala Thr Tyr Ser Leu Thr Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Ser Leu Leu Leu Leu Ala Leu Pro Gln Gln Ala Tyr Ala Tyr Asp Ala 
                805                 810                 815     


Ser Val His Gly Gln Ile Gly Ala Ala Leu Leu Val Met Ile Thr Leu 
            820                 825                 830         


Phe Thr Leu Thr Pro Gly Tyr Lys Thr Leu Leu Ser Arg Phe Leu Trp 
        835                 840                 845             


Trp Leu Cys Tyr Leu Leu Thr Leu Gly Glu Ala Met Val Gln Glu Trp 
    850                 855                 860                 


Ala Pro Pro Met Gln Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Ala 
865                 870                 875                 880 


Val Ala Ile Phe Tyr Pro Gly Val Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Val Leu Gly Pro Ala Tyr Leu Leu Lys Gly Ala Leu Thr Arg 
            900                 905                 910         


Val Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Met Cys Thr Met 
        915                 920                 925             


Ala Arg His Leu Ala Gly Gly Arg Tyr Val Gln Met Ala Leu Leu Ala 
    930                 935                 940                 


Leu Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Thr Pro Met 
945                 950                 955                 960 


Ser Asp Trp Ala Ala Ser Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Ile Ile Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Ala Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Ser Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Ala Ile Val Val Ser  Met Thr Gly 
    1040                 1045                 1050             


Arg Asp  Arg Thr Glu Gln Ala  Gly Glu Val Gln Ile  Leu Ser Thr 
    1055                 1060                 1065             


Val Ser  Gln Ser Phe Leu Gly  Thr Thr Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Leu Arg 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Ser Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Glu  Pro Cys Lys 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Ala Arg Arg Arg Gly  Asp Lys Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Ile Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Arg Gly His Val  Val Gly Leu Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ser  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Thr Leu  Asp Val Val Thr Arg  Ser Pro Thr Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Val Ala Tyr 
    1235                 1240                 1245             


Ala Ala  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Leu Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Met  Thr Gly Glu 
    1280                 1285                 1290             


Ala Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Ser Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Val  Asp Ala Thr Ser Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Thr Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Thr Pro His Pro Asp  Ile Glu Glu 
    1355                 1360                 1365             


Val Gly  Leu Gly Arg Glu Gly  Glu Ile Pro Phe Tyr  Gly Arg Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ser Cys Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Leu Asn Ala Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Ile Ile  Pro Ala Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Ala  Val Asp Phe Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Thr  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Gln  Gly Thr Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Thr Gly Glu  Arg Ala Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Asp 
    1520                 1525                 1530             


Leu Thr  Pro Ala Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Ala Gly Glu  Asn Phe Ala Tyr Leu  Val Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Ala  Met Trp Lys Cys Leu  Ala Arg Leu Lys Pro  Thr Leu Ala 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Pro Ile  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Gly  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Val Met  Thr Ser Thr Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ala Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Val Ser  Ile Ile Gly Arg Leu  His Val Asn Gln Arg  Val Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Val Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Arg Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Ile 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Ser Lys  Gln Ala Gln Asp Ile  Gln Pro Ala Met Gln  Ala Ser Trp 
    1745                 1750                 1755             


Pro Lys  Val Glu Gln Phe Trp  Ala Arg His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ser Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Met Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Ile  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Ser Met  Glu Asp Val Ile Asn  Leu Leu Pro Gly Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Pro Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Thr  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Leu Leu Gly 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Asn Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Ile Pro  Cys Gly Gly Ser Trp  Leu Arg Asp 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Thr  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Thr  Ser Lys Leu Phe Pro  Lys Met Pro Gly Leu  Pro Phe Val 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Ile 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly Asn Val 
    2030                 2035                 2040             


Arg Leu  Gly Ser Met Arg Ile  Thr Gly Pro Lys Thr  Cys Met Asn 
    2045                 2050                 2055             


Ile Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Gln 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Ala Pro  Asn Phe Lys Val Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Ala  Glu Val Thr Gln His  Gly Ser Tyr 
    2090                 2095                 2100             


His Tyr  Ile Thr Gly Leu Thr  Thr Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Leu  Pro Ser Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Thr  Pro Lys Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Ser  Phe Cys Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Asp Val Leu  Met Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Glu Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Arg Ala Thr Cys Thr  Thr His Gly 
    2210                 2215                 2220             


Lys Ala  Tyr Asp Val Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Gly Ser Lys Val  Val Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Pro Met Val  Glu Glu Arg Ser Asp  Leu Glu Pro 
    2255                 2260                 2265             


Ser Ile  Pro Ser Glu Tyr Met  Leu Pro Lys Lys Arg  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ala Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Ser  Trp Lys Arg Pro Asp  Tyr Gln Pro Ala Thr  Val Ala Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Pro Arg  Lys Thr Pro Thr Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Thr Val Gly Leu  Ser Glu Asp Ser Ile  Gly Asp Ala 
    2330                 2335                 2340             


Leu Gln  Gln Leu Ala Ile Lys  Ser Phe Gly Gln Pro  Pro Pro Ser 
    2345                 2350                 2355             


Gly Asp  Ser Gly Leu Ser Thr  Gly Ala Gly Ala Ala  Asp Ser Gly 
    2360                 2365                 2370             


Ser Gln  Thr Pro Pro Asp Glu  Leu Ala Leu Ser Glu  Thr Gly Ser 
    2375                 2380                 2385             


Ile Ser  Ser Met Pro Pro Leu  Glu Gly Glu Leu Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Pro Glu Gln Val Glu  Pro Gln Pro Pro Pro  Gln Gly Gly 
    2405                 2410                 2415             


Val Ala  Ala Pro Gly Ser Asp  Ser Gly Ser Trp Ser  Thr Cys Ser 
    2420                 2425                 2430             


Glu Glu  Asp Asp Ser Val Val  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Ser Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Leu Arg Tyr  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Cys Thr Thr Thr Lys  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Met Gln  Val Leu Asp Ser Tyr  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Lys Asp Ile Lys Leu  Ala Ala Ser Lys Val  Thr Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Met Glu Glu Ala  Cys Gln Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Arg  Ser Lys Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Gly  Arg Ala Val Asn His  Ile Lys Ser Val Trp  Lys Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Ser Glu Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Val Asp  Pro Thr Lys Gly Gly  Lys Lys Ala 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Thr Gln Lys Leu Pro  Gln Ala Val 
    2615                 2620                 2625             


Met Gly  Ala Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Gln Arg Val 
    2630                 2635                 2640             


Glu Phe  Leu Leu Lys Ala Trp  Ala Glu Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Arg Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Glu Glu  Ala His Thr Ala Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Phe Asn  Ser Lys Gly Gln Thr  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Ile  Thr Cys Tyr Val Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Ile Ala Pro Thr Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Thr Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Pro  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Gly Pro Gln Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Ala  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Ala Arg Met  Val Leu Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Met Ala Gln Asp Thr  Leu Asp Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Ser Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Asp Ala 
    2900                 2905                 2910             


Phe Ser  Met His Thr Tyr Ser  His His Glu Leu Thr  Arg Val Ala 
    2915                 2920                 2925             


Ser Ala  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Val Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ser  Arg Gly Gly 
    2945                 2950                 2955             


Lys Ala  Ala Val Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Arg  Leu Leu Asp 
    2975                 2980                 2985             


Leu Ser  Ser Trp Phe Thr Val  Gly Ala Gly Gly Gly  Asp Ile Phe 
    2990                 2995                 3000             


His Ser  Val Ser Arg Ala Arg  Pro Arg Ser Leu Leu  Phe Gly Leu 
    3005                 3010                 3015             


Leu Leu  Leu Phe Val Gly Val  Gly Leu Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  71
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  71

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala 
            180                 185                 190         


Glu Val Lys Asn Ile Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Thr 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Val Gly Asn Ala Ser Gln Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Arg 
    370                 375                 380                 


Thr His Thr Val Gly Gly Ser Ala Ala Gln Thr Thr Gly Arg Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Asp Met Gly Pro Arg Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr His Ser Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ser Ala Cys Arg Ser Ile Glu Ala 
    450                 455                 460                 


Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Gln Cys 
                485                 490                 495     


Gly Val Val Ser Ala Lys Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Leu Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Ser 
545                 550                 555                 560 


Gly Tyr Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Phe Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Val Ile Leu His Ala Ala Ser Ala Ala Ser Cys Asn Gly 
        755                 760                 765             


Phe Leu Tyr Phe Val Ile Phe Phe Val Ala Ala Trp Tyr Ile Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Ala Thr Tyr Ser Leu Thr Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Ser Leu Leu Leu Leu Ala Leu Pro Gln Gln Ala Tyr Ala Tyr Asp Ala 
                805                 810                 815     


Ser Val His Gly Gln Ile Gly Ala Ala Leu Leu Val Met Ile Thr Leu 
            820                 825                 830         


Phe Thr Leu Thr Pro Gly Tyr Lys Thr Leu Leu Ser Arg Phe Leu Trp 
        835                 840                 845             


Trp Leu Cys Tyr Leu Leu Thr Leu Gly Glu Ala Met Val Gln Glu Trp 
    850                 855                 860                 


Ala Pro Pro Met Gln Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Ala 
865                 870                 875                 880 


Val Ala Ile Phe Tyr Pro Gly Val Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Val Leu Gly Pro Ala Tyr Leu Leu Lys Gly Ala Leu Thr Arg 
            900                 905                 910         


Val Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Met Cys Thr Met 
        915                 920                 925             


Ala Arg His Leu Ala Gly Gly Arg Tyr Val Gln Met Ala Leu Leu Ala 
    930                 935                 940                 


Leu Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Thr Pro Met 
945                 950                 955                 960 


Ser Asp Trp Ala Ala Ser Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Ile Ile Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Ala Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Ser Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Thr Ile Val Val Ser  Met Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Thr Glu Gln Ala  Gly Glu Ile Gln Val  Leu Ser Thr 
    1055                 1060                 1065             


Val Thr  Gln Ser Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Ser Arg 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Ser Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Glu  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Ala Arg Arg Arg Gly  Asp Lys Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Arg Gly His Ala  Val Gly Val Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ser  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Thr Leu  Asp Ile Val Thr Arg  Ser Pro Thr Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Val Ala Tyr 
    1235                 1240                 1245             


Ala Ala  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Leu Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Ala 
    1280                 1285                 1290             


Pro Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Gly Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Val  Asp Ser Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Thr Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Thr Pro His Pro Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly Gln Glu Gly  Glu Ile Pro Phe Tyr  Gly Arg Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ser Tyr Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Leu Asn Ser Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Val  Val Asp Phe Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Ile Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Thr Gly Glu  Arg Ala Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ser Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Ser Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Val 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ser Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Val Met  Thr Ser Thr Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ala Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Val Cys  Ile Ile Gly Arg Leu  His Ile Asn Gln Arg  Ala Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Val Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Arg Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Ile 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Ser Lys  Gln Ala Gln Asp Ile  Gln Pro Thr Val Gln  Ala Ser Trp 
    1745                 1750                 1755             


Pro Lys  Val Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ser Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Leu Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Ile  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Ser Met  Glu Asp Val Val Asn  Leu Leu Pro Gly Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Pro Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Thr  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Leu Leu Gly 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Asn Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Ile Pro  Cys Gly Gly Ser Trp  Leu Arg Asp 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Thr  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Thr  Ser Lys Leu Phe Pro  Lys Met Pro Gly Leu  Pro Phe Val 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Ile 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly Asn Val 
    2030                 2035                 2040             


Arg Leu  Gly Ser Met Arg Ile  Thr Gly Pro Lys Thr  Cys Met Asn 
    2045                 2050                 2055             


Ile Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Gln 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Ala Pro  Asn Phe Lys Val Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Ala  Glu Val Thr Gln His  Gly Ser Tyr 
    2090                 2095                 2100             


His Tyr  Ile Thr Gly Leu Thr  Thr Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Leu  Pro Ser Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Thr  Pro Lys Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Ser  Phe Cys Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Asp Val Leu  Met Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Glu Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Arg Ala Thr Cys Thr  Thr His Gly 
    2210                 2215                 2220             


Lys Ala  Tyr Asp Val Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Gly Ser Lys Val  Val Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Pro Met Val  Glu Glu Arg Ser Asp  Leu Glu Pro 
    2255                 2260                 2265             


Ser Ile  Pro Ser Glu Tyr Met  Leu Pro Lys Lys Arg  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ala Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Ser  Trp Lys Arg Pro Asp  Tyr Gln Pro Ala Thr  Val Ala Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Pro Arg  Lys Thr Pro Thr Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Thr Val Gly Leu  Ser Glu Asp Ser Ile  Gly Asp Ala 
    2330                 2335                 2340             


Leu Gln  Gln Leu Ala Ile Lys  Ser Phe Gly Gln Pro  Pro Pro Ser 
    2345                 2350                 2355             


Gly Asp  Ser Gly Leu Ser Thr  Gly Ala Gly Ala Ala  Asp Ser Gly 
    2360                 2365                 2370             


Ser Gln  Thr Pro Pro Asp Glu  Leu Ala Leu Ser Glu  Thr Gly Ser 
    2375                 2380                 2385             


Ile Ser  Ser Met Pro Pro Leu  Glu Gly Glu Leu Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Pro Glu Gln Val Glu  Pro Gln Pro Pro Pro  Gln Gly Gly 
    2405                 2410                 2415             


Val Ala  Ala Pro Gly Ser Asp  Ser Gly Ser Trp Ser  Thr Cys Ser 
    2420                 2425                 2430             


Glu Glu  Asp Asp Ser Val Val  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Ser Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Leu Arg Tyr  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Cys Thr Thr Ser Lys  Ser Ala Ser Gln Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Thr Gln  Val Leu Asp Ala His  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Lys Asp Ile Lys Leu  Ala Ala Ser Lys Val  Ser Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Leu Glu Glu Ala  Cys Gln Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Arg  Ser Lys Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Gly  Arg Ala Val Asn His  Ile Lys Ser Val Trp  Lys Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Pro Gln Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Val Asp  Pro Ala Lys Gly Gly  Lys Lys Pro 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Thr Gln Lys Leu Pro  Gln Ala Val 
    2615                 2620                 2625             


Met Gly  Ala Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Gln Arg Val 
    2630                 2635                 2640             


Glu Tyr  Leu Leu Lys Ala Trp  Ala Glu Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Gln Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Glu Glu  Ala Arg Thr Ala Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Phe Asn  Ser Lys Gly Gln Thr  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Ile  Thr Cys Tyr Val Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Val Ala Pro Thr Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Thr Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Pro  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Gly Pro Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro Leu Ala  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Ile Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Leu Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Met Val Gln Asp Thr  Leu Asp Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ser Val Tyr Ser  Val Asn Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Asp Ala 
    2900                 2905                 2910             


Phe Ser  Met His Thr Tyr Ser  His His Glu Leu Thr  Arg Val Ala 
    2915                 2920                 2925             


Ser Ala  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Val Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ser  Arg Gly Gly 
    2945                 2950                 2955             


Lys Ala  Ala Val Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Arg  Leu Leu Asp 
    2975                 2980                 2985             


Leu Ser  Ser Trp Phe Thr Val  Gly Ala Gly Gly Gly  Asp Ile Phe 
    2990                 2995                 3000             


His Ser  Val Ser Arg Ala Arg  Pro Arg Ser Leu Leu  Phe Gly Leu 
    3005                 3010                 3015             


Leu Leu  Leu Phe Val Gly Val  Gly Leu Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  72
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  72

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala 
            180                 185                 190         


Glu Val Lys Asn Ile Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Thr 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Val Gly Asn Ala Ser Gln Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Arg 
    370                 375                 380                 


Thr His Thr Val Gly Gly Ser Ala Ala Gln Thr Thr Gly Arg Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Asp Met Gly Pro Arg Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr His Ser Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ser Ala Cys Arg Ser Ile Glu Ala 
    450                 455                 460                 


Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Gln Cys 
                485                 490                 495     


Gly Val Val Ser Ala Lys Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Leu Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Ser 
545                 550                 555                 560 


Gly Tyr Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Phe Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Val Ile Leu His Ala Ala Ser Ala Ala Ser Cys Asn Gly 
        755                 760                 765             


Phe Leu Tyr Phe Val Ile Phe Phe Val Ala Ala Trp Tyr Ile Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Ala Thr Tyr Ser Leu Thr Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Ser Leu Leu Leu Leu Ala Leu Pro Gln Gln Ala Tyr Ala Tyr Asp Ala 
                805                 810                 815     


Ser Val His Gly Gln Ile Gly Ala Ala Leu Leu Val Met Ile Thr Leu 
            820                 825                 830         


Phe Thr Leu Thr Pro Gly Tyr Lys Thr Leu Leu Ser Arg Phe Leu Trp 
        835                 840                 845             


Trp Leu Cys Tyr Leu Leu Thr Leu Gly Glu Ala Met Val Gln Glu Trp 
    850                 855                 860                 


Ala Pro Pro Met Gln Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Ala 
865                 870                 875                 880 


Val Ala Ile Phe Tyr Pro Gly Val Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Val Leu Gly Pro Ala Tyr Leu Leu Lys Gly Ala Leu Thr Arg 
            900                 905                 910         


Val Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Met Cys Thr Met 
        915                 920                 925             


Ala Arg His Leu Ala Gly Gly Arg Tyr Val Gln Met Ala Leu Leu Ala 
    930                 935                 940                 


Leu Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Thr Pro Met 
945                 950                 955                 960 


Ser Asp Trp Ala Ala Ser Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Ile Ile Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Ala Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Ser Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Thr Ile Val Val Ser  Met Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Thr Glu Gln Ala  Gly Glu Ile Gln Val  Leu Ser Thr 
    1055                 1060                 1065             


Val Thr  Gln Ser Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Ser Arg 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Ser Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Glu  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Ala Arg Arg Arg Gly  Asp Lys Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Arg Gly His Ala  Val Gly Val Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ser  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Thr Leu  Asp Ile Val Thr Arg  Ser Pro Thr Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Val Ala Tyr 
    1235                 1240                 1245             


Ala Ala  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Leu Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Ala 
    1280                 1285                 1290             


Pro Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Gly Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Val  Asp Ser Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Thr Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Thr Pro His Pro Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly Gln Glu Gly  Glu Ile Pro Phe Tyr  Gly Arg Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ser Tyr Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Leu Asn Ser Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Val  Val Asp Phe Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Ile Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Thr Gly Glu  Arg Ala Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ser Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Ser Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Val 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ser Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Val Met  Thr Ser Thr Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ala Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Val Cys  Ile Ile Gly Arg Leu  His Ile Asn Gln Arg  Ala Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Val Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Arg Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Ile 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Ser Lys  Gln Ala Gln Asp Ile  Gln Pro Thr Val Gln  Ala Ser Trp 
    1745                 1750                 1755             


Pro Lys  Val Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ser Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Leu Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Ile  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Ser Met  Glu Asp Val Val Asn  Leu Leu Pro Gly Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Pro Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Thr  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Leu Leu Gly 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Asn Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Ile Pro  Cys Gly Gly Ser Trp  Leu Arg Asp 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Thr  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Thr  Ser Lys Leu Phe Pro  Lys Met Pro Gly Leu  Pro Phe Val 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Ile 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly Asn Val 
    2030                 2035                 2040             


Arg Leu  Gly Ser Met Arg Ile  Thr Gly Pro Lys Thr  Cys Met Asn 
    2045                 2050                 2055             


Ile Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Gln 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Ala Pro  Asn Phe Lys Val Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Ala  Glu Val Thr Gln His  Gly Ser Tyr 
    2090                 2095                 2100             


His Tyr  Ile Thr Gly Leu Thr  Thr Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Leu  Pro Ser Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Thr  Pro Lys Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Ser  Phe Cys Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Asp Val Leu  Met Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Glu Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Arg Ala Thr Cys Thr  Thr His Gly 
    2210                 2215                 2220             


Lys Ala  Tyr Asp Val Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Gly Ser Lys Val  Val Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Pro Met Val  Glu Glu Arg Ser Asp  Leu Glu Pro 
    2255                 2260                 2265             


Ser Ile  Pro Ser Glu Tyr Met  Leu Pro Lys Lys Arg  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ala Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Ser  Trp Lys Arg Pro Asp  Tyr Gln Pro Ala Thr  Val Ala Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Pro Arg  Lys Thr Pro Thr Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Thr Val Gly Leu  Ser Glu Asp Ser Ile  Gly Asp Ala 
    2330                 2335                 2340             


Leu Gln  Gln Leu Ala Ile Lys  Ser Phe Gly Gln Pro  Pro Pro Ser 
    2345                 2350                 2355             


Gly Asp  Ser Gly Leu Ser Thr  Gly Ala Gly Ala Ala  Asp Ser Gly 
    2360                 2365                 2370             


Ser Gln  Thr Pro Pro Asp Glu  Leu Ala Leu Ser Glu  Thr Gly Ser 
    2375                 2380                 2385             


Ile Ser  Ser Met Pro Pro Leu  Glu Gly Glu Leu Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Pro Glu Gln Val Glu  Pro Gln Pro Pro Pro  Gln Gly Gly 
    2405                 2410                 2415             


Val Ala  Ala Pro Gly Ser Asp  Ser Gly Ser Trp Ser  Thr Cys Ser 
    2420                 2425                 2430             


Glu Glu  Asp Asp Ser Val Val  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Ser Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Leu Arg Tyr  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Cys Thr Thr Thr Lys  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Met Gln  Val Leu Asp Ser Tyr  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Lys Asp Ile Lys Leu  Ala Ala Ser Lys Val  Thr Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Met Glu Glu Ala  Cys Gln Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Arg  Ser Lys Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Gly  Arg Ala Val Asn His  Ile Lys Ser Val Trp  Lys Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Ser Glu Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Val Asp  Pro Thr Lys Gly Gly  Lys Lys Ala 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Thr Gln Lys Leu Pro  Gln Ala Val 
    2615                 2620                 2625             


Met Gly  Ala Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Gln Arg Val 
    2630                 2635                 2640             


Glu Tyr  Leu Leu Lys Ala Trp  Ala Glu Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Gln Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Glu Glu  Ala Arg Thr Ala Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Phe Asn  Ser Lys Gly Gln Thr  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Ile  Thr Cys Tyr Val Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Val Ala Pro Thr Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Thr Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Pro  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Gly Pro Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro Leu Ala  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Ile Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Leu Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Met Val Gln Asp Thr  Leu Asp Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ser Val Tyr Ser  Val Asn Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Asp Ala 
    2900                 2905                 2910             


Phe Ser  Met His Thr Tyr Ser  His His Glu Leu Thr  Arg Val Ala 
    2915                 2920                 2925             


Ser Ala  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Val Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ser  Arg Gly Gly 
    2945                 2950                 2955             


Lys Ala  Ala Val Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Arg  Leu Leu Asp 
    2975                 2980                 2985             


Leu Ser  Ser Trp Phe Thr Val  Gly Ala Gly Gly Gly  Asp Ile Phe 
    2990                 2995                 3000             


His Ser  Val Ser Arg Ala Arg  Pro Arg Ser Leu Leu  Phe Gly Leu 
    3005                 3010                 3015             


Leu Leu  Leu Phe Val Gly Val  Gly Leu Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  73
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  73

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala 
            180                 185                 190         


Glu Val Lys Asn Ile Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Thr 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Val Gly Asn Ala Ser Gln Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Arg 
    370                 375                 380                 


Thr His Thr Val Gly Gly Ser Ala Ala Gln Thr Thr Gly Arg Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Asp Met Gly Pro Arg Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr His Ser Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ser Ala Cys Arg Ser Ile Glu Ala 
    450                 455                 460                 


Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Gln Cys 
                485                 490                 495     


Gly Val Val Ser Ala Lys Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Leu Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Ser 
545                 550                 555                 560 


Gly Tyr Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Phe Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Val Ile Leu His Ala Ala Ser Ala Ala Ser Cys Asn Gly 
        755                 760                 765             


Phe Leu Tyr Phe Val Ile Phe Phe Val Ala Ala Trp Tyr Ile Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Ala Thr Tyr Ser Leu Thr Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Ser Leu Leu Leu Leu Ala Leu Pro Gln Gln Ala Tyr Ala Tyr Asp Ala 
                805                 810                 815     


Ser Val His Gly Gln Ile Gly Ala Ala Leu Leu Val Met Ile Thr Leu 
            820                 825                 830         


Phe Thr Leu Thr Pro Gly Tyr Lys Thr Leu Leu Ser Arg Phe Leu Trp 
        835                 840                 845             


Trp Leu Cys Tyr Leu Leu Thr Leu Gly Glu Ala Met Val Gln Glu Trp 
    850                 855                 860                 


Ala Pro Pro Met Gln Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Ala 
865                 870                 875                 880 


Val Ala Ile Phe Tyr Pro Gly Val Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Val Leu Gly Pro Ala Tyr Leu Leu Lys Gly Ala Leu Thr Arg 
            900                 905                 910         


Val Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Met Cys Thr Met 
        915                 920                 925             


Ala Arg His Leu Ala Gly Gly Arg Tyr Val Gln Met Ala Leu Leu Ala 
    930                 935                 940                 


Leu Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Thr Pro Met 
945                 950                 955                 960 


Ser Asp Trp Ala Ala Ser Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Ile Ile Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Ala Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Ser Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Thr Ile Val Val Ser  Met Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Thr Glu Gln Ala  Gly Glu Ile Gln Val  Leu Ser Thr 
    1055                 1060                 1065             


Val Thr  Gln Ser Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Ser Arg 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Ser Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Glu  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Ala Arg Arg Arg Gly  Asp Lys Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Arg Gly His Ala  Val Gly Val Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ser  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Thr Leu  Asp Ile Val Thr Arg  Ser Pro Thr Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Val Ala Tyr 
    1235                 1240                 1245             


Ala Ala  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Leu Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Ala 
    1280                 1285                 1290             


Pro Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Gly Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Val  Asp Ser Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Thr Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Thr Pro His Pro Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly Gln Glu Gly  Glu Ile Pro Phe Tyr  Gly Arg Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ser Tyr Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Leu Asn Ser Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Val  Val Asp Phe Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Ile Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Thr Gly Glu  Arg Ala Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ser Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Ser Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Val 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ser Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Val Met  Thr Ser Thr Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ala Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Val Cys  Ile Ile Gly Arg Leu  His Ile Asn Gln Arg  Ala Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Val Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Arg Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Ile 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Ser Lys  Gln Ala Gln Asp Ile  Gln Pro Thr Val Gln  Ala Ser Trp 
    1745                 1750                 1755             


Pro Lys  Val Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ser Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Leu Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Ile  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Ser Met  Glu Asp Val Val Asn  Leu Leu Pro Gly Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Pro Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Thr  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Leu Leu Gly 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Asn Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Ile Pro  Cys Gly Gly Ser Trp  Leu Arg Asp 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Thr  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Thr  Ser Lys Leu Phe Pro  Lys Met Pro Gly Leu  Pro Phe Val 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Ile 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly Asn Val 
    2030                 2035                 2040             


Arg Leu  Gly Ser Met Arg Ile  Thr Gly Pro Lys Thr  Cys Met Asn 
    2045                 2050                 2055             


Ile Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Gln 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Ala Pro  Asn Phe Lys Val Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Ala  Glu Val Thr Gln His  Gly Ser Tyr 
    2090                 2095                 2100             


His Tyr  Ile Thr Gly Leu Thr  Thr Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Leu  Pro Ser Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Thr  Pro Lys Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Ser  Phe Cys Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Asp Val Leu  Met Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Glu Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Arg Ala Thr Cys Thr  Thr His Gly 
    2210                 2215                 2220             


Lys Ala  Tyr Asp Val Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Gly Ser Lys Val  Val Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Pro Met Val  Glu Glu Arg Ser Asp  Leu Glu Pro 
    2255                 2260                 2265             


Ser Ile  Pro Ser Glu Tyr Met  Leu Pro Lys Lys Arg  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ala Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Ser  Trp Lys Arg Pro Asp  Tyr Gln Pro Ala Thr  Val Ala Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Pro Arg  Lys Thr Pro Thr Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Thr Val Gly Leu  Ser Glu Asp Ser Ile  Gly Asp Ala 
    2330                 2335                 2340             


Leu Gln  Gln Leu Ala Ile Lys  Ser Phe Gly Gln Pro  Pro Pro Ser 
    2345                 2350                 2355             


Gly Asp  Ser Gly Leu Ser Thr  Gly Ala Gly Ala Ala  Asp Ser Gly 
    2360                 2365                 2370             


Ser Gln  Thr Pro Pro Asp Glu  Leu Ala Leu Ser Glu  Thr Gly Ser 
    2375                 2380                 2385             


Ile Ser  Ser Met Pro Pro Leu  Glu Gly Glu Leu Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Pro Glu Gln Val Glu  Pro Gln Pro Pro Pro  Gln Gly Gly 
    2405                 2410                 2415             


Val Ala  Ala Pro Gly Ser Asp  Ser Gly Ser Trp Ser  Thr Cys Ser 
    2420                 2425                 2430             


Glu Glu  Asp Asp Ser Val Val  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Ser Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Leu Arg Tyr  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Cys Thr Thr Thr Lys  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Met Gln  Val Leu Asp Ser Tyr  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Lys Asp Ile Lys Leu  Ala Ala Ser Lys Val  Thr Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Met Glu Glu Ala  Cys Gln Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Arg  Ser Lys Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Gly  Arg Ala Val Asn His  Ile Lys Ser Val Trp  Lys Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Ser Glu Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Val Asp  Pro Thr Lys Gly Gly  Lys Lys Ala 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Thr Gln Lys Leu Pro  Gln Ala Val 
    2615                 2620                 2625             


Met Gly  Ala Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Gln Arg Val 
    2630                 2635                 2640             


Glu Phe  Leu Leu Lys Ala Trp  Ala Glu Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Arg Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Glu Glu  Ala His Thr Ala Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Phe Asn  Ser Lys Gly Gln Thr  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Ile  Thr Cys Tyr Val Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Ile Ala Pro Thr Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Thr Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Pro  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Gly Pro Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro Leu Ala  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Ile Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Leu Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Met Val Gln Asp Thr  Leu Asp Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ser Val Tyr Ser  Val Asn Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Asp Ala 
    2900                 2905                 2910             


Phe Ser  Met His Thr Tyr Ser  His His Glu Leu Thr  Arg Val Ala 
    2915                 2920                 2925             


Ser Ala  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Val Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ser  Arg Gly Gly 
    2945                 2950                 2955             


Lys Ala  Ala Val Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Arg  Leu Leu Asp 
    2975                 2980                 2985             


Leu Ser  Ser Trp Phe Thr Val  Gly Ala Gly Gly Gly  Asp Ile Phe 
    2990                 2995                 3000             


His Ser  Val Ser Arg Ala Arg  Pro Arg Ser Leu Leu  Phe Gly Leu 
    3005                 3010                 3015             


Leu Leu  Leu Phe Val Gly Val  Gly Leu Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  74
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  74

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala 
            180                 185                 190         


Glu Val Lys Asn Ile Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Thr 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Val Gly Asn Ala Ser Gln Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Arg 
    370                 375                 380                 


Thr His Thr Val Gly Gly Ser Ala Ala Gln Thr Thr Gly Arg Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Asp Met Gly Pro Arg Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr His Ser Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ser Ala Cys Arg Ser Ile Glu Ala 
    450                 455                 460                 


Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Gln Cys 
                485                 490                 495     


Gly Val Val Ser Ala Lys Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Leu Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Ser 
545                 550                 555                 560 


Gly Tyr Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Phe Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Val Ile Leu His Ala Ala Ser Ala Ala Ser Cys Asn Gly 
        755                 760                 765             


Phe Leu Tyr Phe Val Ile Phe Ser Val Ala Ala Trp Tyr Ile Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Ala Thr Tyr Ser Leu Thr Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Ser Leu Leu Leu Leu Ala Leu Pro Gln Gln Ala Tyr Ala Tyr Asp Ala 
                805                 810                 815     


Ser Val His Gly Gln Ile Gly Ala Ala Leu Leu Val Met Ile Thr Leu 
            820                 825                 830         


Phe Thr Leu Thr Pro Gly Tyr Lys Thr Leu Leu Ser Arg Phe Leu Trp 
        835                 840                 845             


Trp Leu Cys Tyr Leu Leu Thr Leu Gly Glu Ala Met Val Gln Glu Trp 
    850                 855                 860                 


Ala Pro Pro Met Gln Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Ala 
865                 870                 875                 880 


Val Ala Ile Phe Tyr Pro Gly Val Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Val Leu Gly Pro Ala Tyr Leu Leu Lys Gly Ala Leu Thr Arg 
            900                 905                 910         


Val Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Met Cys Thr Met 
        915                 920                 925             


Ala Arg His Leu Ala Gly Gly Arg Tyr Val Gln Met Ala Leu Leu Ala 
    930                 935                 940                 


Leu Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Thr Pro Met 
945                 950                 955                 960 


Ser Asp Trp Ala Ala Ser Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Ile Ile Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Ala Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Ser Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Thr Ile Val Val Ser  Met Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Thr Glu Gln Ala  Gly Glu Ile Gln Val  Leu Ser Thr 
    1055                 1060                 1065             


Val Thr  Gln Ser Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Ser Arg 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Ser Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Glu  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Ala Arg Arg Arg Gly  Asp Lys Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Arg Gly His Ala  Val Gly Val Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ser  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Thr Leu  Asp Ile Val Thr Arg  Ser Pro Thr Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Val Ala Tyr 
    1235                 1240                 1245             


Ala Ala  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Leu Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Ala 
    1280                 1285                 1290             


Pro Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Gly Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Val  Asp Ser Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Thr Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Thr Pro His Pro Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly Gln Glu Gly  Glu Ile Pro Phe Tyr  Gly Arg Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ser Tyr Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Leu Asn Ser Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Val  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Ile Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Thr Gly Glu  Arg Ala Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ser Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Ser Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Val 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ser Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Val Met  Thr Ser Thr Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Val Cys  Ile Ile Gly Arg Leu  His Ile Asn Gln Arg  Ala Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Val Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Arg Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Ile 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Ser Lys  Gln Ala Gln Asp Ile  Gln Pro Thr Val Gln  Ala Ser Trp 
    1745                 1750                 1755             


Pro Lys  Val Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ser Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Leu Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Ile  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Ser Met  Glu Asp Val Val Asn  Leu Leu Pro Gly Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Pro Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Thr  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Leu Leu Gly 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Asn Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Ile Pro  Cys Gly Gly Ser Trp  Leu Arg Asp 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Thr  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Thr  Ser Lys Leu Phe Pro  Lys Met Pro Gly Leu  Pro Phe Val 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Ile 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly Asn Val 
    2030                 2035                 2040             


Arg Leu  Gly Ser Met Arg Ile  Thr Gly Pro Lys Thr  Cys Met Asn 
    2045                 2050                 2055             


Ile Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Gln 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Ala Pro  Asn Phe Lys Val Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Ala  Glu Val Thr Gln His  Gly Ser Tyr 
    2090                 2095                 2100             


His Tyr  Ile Thr Gly Leu Thr  Thr Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Leu  Pro Ser Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Thr  Pro Lys Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Ser  Phe Cys Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Asp Val Leu  Met Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Glu Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Arg Ala Thr Cys Thr  Thr His Gly 
    2210                 2215                 2220             


Lys Ala  Tyr Asp Val Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Gly Ser Lys Val  Val Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Pro Met Val  Glu Glu Arg Ser Asp  Leu Glu Pro 
    2255                 2260                 2265             


Ser Ile  Pro Ser Glu Tyr Met  Leu Pro Lys Lys Arg  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ala Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Ser  Trp Lys Arg Pro Asp  Tyr Gln Pro Ala Thr  Val Ala Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Pro Arg  Lys Thr Pro Thr Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Thr Val Gly Leu  Ser Glu Asp Ser Ile  Gly Asp Ala 
    2330                 2335                 2340             


Leu Gln  Gln Leu Ala Ile Lys  Ser Phe Gly Gln Pro  Pro Pro Ser 
    2345                 2350                 2355             


Gly Asp  Ser Gly Leu Ser Thr  Gly Ala Gly Ala Ala  Asp Ser Gly 
    2360                 2365                 2370             


Ser Gln  Thr Pro Pro Asp Glu  Leu Ala Leu Ser Glu  Thr Gly Ser 
    2375                 2380                 2385             


Ile Ser  Ser Met Pro Pro Leu  Glu Gly Glu Leu Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Pro Glu Gln Val Glu  Pro Gln Pro Pro Pro  Gln Gly Gly 
    2405                 2410                 2415             


Val Ala  Ala Pro Gly Ser Asp  Ser Gly Ser Trp Ser  Thr Cys Ser 
    2420                 2425                 2430             


Glu Glu  Asp Asp Ser Val Val  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Ser Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Leu Arg Tyr  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Cys Thr Thr Thr Lys  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Met Gln  Val Leu Asp Ser Tyr  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Lys Asp Ile Lys Leu  Ala Ala Ser Lys Val  Thr Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Met Glu Glu Ala  Cys Gln Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Arg  Ser Lys Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Gly  Arg Ala Val Asn His  Ile Lys Ser Val Trp  Lys Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Ser Glu Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Val Asp  Pro Thr Lys Gly Gly  Lys Lys Ala 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Thr Gln Lys Leu Pro  Gln Ala Val 
    2615                 2620                 2625             


Met Gly  Ala Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Gln Arg Val 
    2630                 2635                 2640             


Glu Phe  Leu Leu Lys Ala Trp  Ala Glu Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Arg Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Glu Glu  Ala His Thr Ala Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Phe Asn  Ser Lys Gly Gln Thr  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Ile  Thr Cys Tyr Val Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Ile Ala Pro Thr Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Thr Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Pro  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Gly Pro Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro Leu Ala  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Ile Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Leu Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Met Val Gln Asp Thr  Leu Asp Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ser Val Tyr Ser  Val Asn Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Asp Ala 
    2900                 2905                 2910             


Phe Ser  Met His Thr Tyr Ser  His His Glu Leu Thr  Arg Val Ala 
    2915                 2920                 2925             


Ser Ala  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Val Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ser  Arg Gly Gly 
    2945                 2950                 2955             


Lys Ala  Ala Val Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Arg  Leu Leu Asp 
    2975                 2980                 2985             


Leu Ser  Ser Trp Phe Thr Val  Gly Ala Gly Gly Gly  Asp Ile Phe 
    2990                 2995                 3000             


His Ser  Val Ser Arg Ala Arg  Pro Arg Ser Leu Leu  Phe Gly Leu 
    3005                 3010                 3015             


Leu Leu  Leu Phe Val Gly Val  Gly Leu Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  75
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  75

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala 
            180                 185                 190         


Glu Val Lys Asn Ile Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Thr 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Val Gly Asn Ala Ser Gln Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Arg 
    370                 375                 380                 


Thr His Thr Val Gly Gly Ser Ala Ala Gln Thr Thr Gly Arg Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Asp Met Gly Pro Arg Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr His Ser Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ser Ala Cys Arg Ser Ile Glu Ala 
    450                 455                 460                 


Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Gln Cys 
                485                 490                 495     


Gly Val Val Ser Ala Lys Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Leu Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Ser 
545                 550                 555                 560 


Gly Tyr Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Phe Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Val Ile Leu His Ala Ala Ser Ala Ala Ser Cys Asn Gly 
        755                 760                 765             


Phe Leu Tyr Phe Val Ile Phe Ser Val Ala Ala Trp Tyr Ile Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Ala Thr Tyr Ser Leu Thr Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Ser Leu Leu Leu Leu Ala Leu Pro Gln Gln Ala Tyr Ala Tyr Asp Ala 
                805                 810                 815     


Ser Val His Gly Gln Ile Gly Ala Ala Leu Leu Val Met Ile Thr Leu 
            820                 825                 830         


Phe Thr Leu Thr Pro Gly Tyr Lys Thr Leu Leu Ser Arg Phe Leu Trp 
        835                 840                 845             


Trp Leu Cys Tyr Leu Leu Thr Leu Gly Glu Ala Met Val Gln Glu Trp 
    850                 855                 860                 


Ala Pro Pro Met Gln Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Ala 
865                 870                 875                 880 


Val Ala Ile Phe Tyr Pro Gly Val Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Val Leu Gly Pro Ala Tyr Leu Leu Lys Gly Ala Leu Thr Arg 
            900                 905                 910         


Val Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Met Cys Thr Met 
        915                 920                 925             


Ala Arg His Leu Ala Gly Gly Arg Tyr Val Gln Met Ala Leu Leu Ala 
    930                 935                 940                 


Leu Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Thr Pro Met 
945                 950                 955                 960 


Ser Asp Trp Ala Ala Ser Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Ile Ile Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Ala Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Ser Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Thr Ile Val Val Ser  Met Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Thr Glu Gln Ala  Gly Glu Ile Gln Val  Leu Ser Thr 
    1055                 1060                 1065             


Val Thr  Gln Ser Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Ser Arg 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Ser Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Glu  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Ala Arg Arg Arg Gly  Asp Lys Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Arg Gly His Ala  Val Gly Val Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ser  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Thr Leu  Asp Ile Val Thr Arg  Ser Pro Thr Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Val Ala Tyr 
    1235                 1240                 1245             


Ala Ala  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Leu Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Ala 
    1280                 1285                 1290             


Pro Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Gly Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Val  Asp Ser Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Thr Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Thr Pro His Pro Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly Gln Glu Gly  Glu Ile Pro Phe Tyr  Gly Arg Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ser Tyr Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Leu Asn Ser Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Val  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Ile Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Thr Gly Glu  Arg Ala Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ser Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Ser Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Val 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ser Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Val Met  Thr Ser Thr Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ala Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Val Cys  Ile Ile Gly Arg Leu  His Ile Asn Gln Arg  Ala Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Val Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Arg Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Ile 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Ser Lys  Gln Ala Gln Asp Ile  Gln Pro Thr Val Gln  Ala Ser Trp 
    1745                 1750                 1755             


Pro Lys  Val Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ser Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Leu Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Ile  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Ser Met  Glu Asp Val Val Asn  Leu Leu Pro Gly Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Pro Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Thr  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Leu Leu Gly 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Asn Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Ile Pro  Cys Gly Gly Ser Trp  Leu Arg Asp 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Thr  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Thr  Ser Lys Leu Phe Pro  Lys Met Pro Gly Leu  Pro Phe Val 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Ile 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly Asn Val 
    2030                 2035                 2040             


Arg Leu  Gly Ser Met Arg Ile  Thr Gly Pro Lys Thr  Cys Met Asn 
    2045                 2050                 2055             


Ile Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Gln 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Ala Pro  Asn Phe Lys Val Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Ala  Glu Val Thr Gln His  Gly Ser Tyr 
    2090                 2095                 2100             


His Tyr  Ile Thr Gly Leu Thr  Thr Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Leu  Pro Ser Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Thr  Pro Lys Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Ser  Phe Cys Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Asp Val Leu  Met Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Glu Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Arg Ala Thr Cys Thr  Thr His Gly 
    2210                 2215                 2220             


Lys Ala  Tyr Asp Val Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Gly Ser Lys Val  Val Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Pro Met Val  Glu Glu Arg Ser Asp  Leu Glu Pro 
    2255                 2260                 2265             


Ser Ile  Pro Ser Glu Tyr Met  Leu Pro Lys Lys Arg  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ala Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Ser  Trp Lys Arg Pro Asp  Tyr Gln Pro Ala Thr  Val Ala Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Pro Arg  Lys Thr Pro Thr Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Thr Val Gly Leu  Ser Glu Asp Ser Ile  Gly Asp Ala 
    2330                 2335                 2340             


Leu Gln  Gln Leu Ala Ile Lys  Ser Phe Gly Gln Pro  Pro Pro Ser 
    2345                 2350                 2355             


Gly Asp  Ser Gly Leu Ser Thr  Gly Ala Gly Ala Ala  Asp Ser Gly 
    2360                 2365                 2370             


Ser Gln  Thr Pro Pro Asp Glu  Leu Ala Leu Ser Glu  Thr Gly Ser 
    2375                 2380                 2385             


Ile Ser  Ser Met Pro Pro Leu  Glu Gly Glu Leu Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Pro Glu Gln Val Glu  Pro Gln Pro Pro Pro  Gln Gly Gly 
    2405                 2410                 2415             


Val Ala  Ala Pro Gly Ser Asp  Ser Gly Ser Trp Ser  Thr Cys Ser 
    2420                 2425                 2430             


Glu Glu  Asp Asp Ser Val Val  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Ser Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Leu Arg Tyr  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Cys Thr Thr Thr Lys  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Met Gln  Val Leu Asp Ser Tyr  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Lys Asp Ile Lys Leu  Ala Ala Ser Lys Val  Thr Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Met Glu Glu Ala  Cys Gln Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Arg  Ser Lys Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Gly  Arg Ala Val Asn His  Ile Lys Ser Val Trp  Lys Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Ser Glu Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Val Asp  Pro Thr Lys Gly Gly  Lys Lys Ala 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Thr Gln Lys Leu Pro  Gln Ala Val 
    2615                 2620                 2625             


Met Gly  Ala Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Gln Arg Val 
    2630                 2635                 2640             


Glu Phe  Leu Leu Lys Ala Trp  Ala Glu Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Arg Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Glu Glu  Ala His Thr Ala Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Phe Asn  Ser Lys Gly Gln Thr  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Ile  Thr Cys Tyr Val Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Ile Ala Pro Thr Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Thr Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Pro  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Gly Pro Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro Leu Ala  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Ile Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Leu Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Met Val Gln Asp Thr  Leu Asp Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ser Val Tyr Ser  Val Asn Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Asp Ala 
    2900                 2905                 2910             


Phe Ser  Met His Thr Tyr Ser  His His Glu Leu Thr  Arg Val Ala 
    2915                 2920                 2925             


Ser Ala  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Val Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ser  Arg Gly Gly 
    2945                 2950                 2955             


Lys Ala  Ala Val Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Arg  Leu Leu Asp 
    2975                 2980                 2985             


Leu Ser  Ser Trp Phe Thr Val  Gly Ala Gly Gly Gly  Asp Ile Phe 
    2990                 2995                 3000             


His Ser  Val Ser Arg Ala Arg  Pro Arg Ser Leu Leu  Phe Gly Leu 
    3005                 3010                 3015             


Leu Leu  Leu Phe Val Gly Val  Gly Leu Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  76
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  76

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala 
            180                 185                 190         


Glu Val Lys Asn Ile Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Thr 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Val Gly Asn Ala Ser Gln Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Arg 
    370                 375                 380                 


Thr His Thr Val Gly Gly Ser Ala Ala Gln Thr Thr Gly Arg Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Asp Met Gly Pro Arg Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr His Ser Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ser Ala Cys Arg Ser Ile Glu Ala 
    450                 455                 460                 


Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Gln Cys 
                485                 490                 495     


Gly Val Val Ser Ala Lys Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Leu Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Ser 
545                 550                 555                 560 


Gly Tyr Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Phe Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Val Ile Leu His Ala Ala Ser Ala Ala Ser Cys Asn Gly 
        755                 760                 765             


Phe Leu Tyr Phe Val Ile Phe Ser Val Ala Ala Trp Tyr Ile Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Ala Thr Tyr Ser Leu Thr Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Ser Leu Leu Leu Leu Ala Leu Pro Gln Gln Ala Tyr Ala Tyr Asp Ala 
                805                 810                 815     


Ser Val His Gly Gln Ile Gly Ala Ala Leu Leu Val Met Ile Thr Leu 
            820                 825                 830         


Phe Thr Leu Thr Pro Gly Tyr Lys Thr Leu Leu Ser Arg Phe Leu Trp 
        835                 840                 845             


Trp Leu Cys Tyr Leu Leu Thr Leu Gly Glu Ala Met Val Gln Glu Trp 
    850                 855                 860                 


Ala Pro Pro Met Gln Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Ala 
865                 870                 875                 880 


Val Ala Ile Phe Tyr Pro Gly Val Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Val Leu Gly Pro Ala Tyr Leu Leu Lys Gly Ala Leu Thr Arg 
            900                 905                 910         


Val Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Met Cys Thr Met 
        915                 920                 925             


Ala Arg His Leu Ala Gly Gly Arg Tyr Val Gln Met Ala Leu Leu Ala 
    930                 935                 940                 


Leu Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Thr Pro Met 
945                 950                 955                 960 


Ser Asp Trp Ala Ala Ser Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Ile Ile Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Ala Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Ser Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Thr Ile Val Val Ser  Met Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Thr Glu Gln Ala  Gly Glu Ile Gln Val  Leu Ser Thr 
    1055                 1060                 1065             


Val Thr  Gln Ser Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Ser Arg 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Ser Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Glu  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Ala Arg Arg Arg Gly  Asp Lys Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Arg Gly His Ala  Val Gly Val Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ser  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Thr Leu  Asp Ile Val Thr Arg  Ser Pro Thr Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Val Ala Tyr 
    1235                 1240                 1245             


Ala Ala  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Leu Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Ala 
    1280                 1285                 1290             


Pro Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Gly Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Val  Asp Ser Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Thr Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Thr Pro His Pro Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly Gln Glu Gly  Glu Ile Pro Phe Tyr  Gly Arg Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ser Tyr Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Leu Asn Ser Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Val  Val Asp Phe Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Ile Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Thr Gly Glu  Arg Ala Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ser Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Ser Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Val 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ser Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Val Met  Thr Ser Thr Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Val Cys  Ile Ile Gly Arg Leu  His Ile Asn Gln Arg  Ala Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Val Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Arg Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Ile 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Ser Lys  Gln Ala Gln Asp Ile  Gln Pro Thr Val Gln  Ala Ser Trp 
    1745                 1750                 1755             


Pro Lys  Val Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ser Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Leu Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Ile  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Ser Met  Glu Asp Val Val Asn  Leu Leu Pro Gly Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Pro Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Thr  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Leu Leu Gly 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Asn Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Ile Pro  Cys Gly Gly Ser Trp  Leu Arg Asp 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Thr  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Thr  Ser Lys Leu Phe Pro  Lys Met Pro Gly Leu  Pro Phe Val 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Ile 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly Asn Val 
    2030                 2035                 2040             


Arg Leu  Gly Ser Met Arg Ile  Thr Gly Pro Lys Thr  Cys Met Asn 
    2045                 2050                 2055             


Ile Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Gln 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Ala Pro  Asn Phe Lys Val Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Ala  Glu Val Thr Gln His  Gly Ser Tyr 
    2090                 2095                 2100             


His Tyr  Ile Thr Gly Leu Thr  Thr Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Leu  Pro Ser Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Thr  Pro Lys Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Ser  Phe Cys Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Asp Val Leu  Met Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Glu Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Arg Ala Thr Cys Thr  Thr His Gly 
    2210                 2215                 2220             


Lys Ala  Tyr Asp Val Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Gly Ser Lys Val  Val Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Pro Met Val  Glu Glu Arg Ser Asp  Leu Glu Pro 
    2255                 2260                 2265             


Ser Ile  Pro Ser Glu Tyr Met  Leu Pro Lys Lys Arg  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ala Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Ser  Trp Lys Arg Pro Asp  Tyr Gln Pro Ala Thr  Val Ala Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Pro Arg  Lys Thr Pro Thr Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Thr Val Gly Leu  Ser Glu Asp Ser Ile  Gly Asp Ala 
    2330                 2335                 2340             


Leu Gln  Gln Leu Ala Ile Lys  Ser Phe Gly Gln Pro  Pro Pro Ser 
    2345                 2350                 2355             


Gly Asp  Ser Gly Leu Ser Thr  Gly Ala Gly Ala Ala  Asp Ser Gly 
    2360                 2365                 2370             


Ser Gln  Thr Pro Pro Asp Glu  Leu Ala Leu Ser Glu  Thr Gly Ser 
    2375                 2380                 2385             


Ile Ser  Ser Met Pro Pro Leu  Glu Gly Glu Leu Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Pro Glu Gln Val Glu  Pro Gln Pro Pro Pro  Gln Gly Gly 
    2405                 2410                 2415             


Val Ala  Ala Pro Gly Ser Asp  Ser Gly Ser Trp Ser  Thr Cys Ser 
    2420                 2425                 2430             


Glu Glu  Asp Asp Ser Val Val  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Ser Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Leu Arg Tyr  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Cys Thr Thr Thr Lys  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Met Gln  Val Leu Asp Ser Tyr  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Lys Asp Ile Lys Leu  Ala Ala Ser Lys Val  Thr Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Met Glu Glu Ala  Cys Gln Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Arg  Ser Lys Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Gly  Arg Ala Val Asn His  Ile Lys Ser Val Trp  Lys Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Ser Glu Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Val Asp  Pro Thr Lys Gly Gly  Lys Lys Ala 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Thr Gln Lys Leu Pro  Gln Ala Val 
    2615                 2620                 2625             


Met Gly  Ala Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Gln Arg Val 
    2630                 2635                 2640             


Glu Phe  Leu Leu Lys Ala Trp  Ala Glu Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Arg Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Glu Glu  Ala His Thr Ala Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Phe Asn  Ser Lys Gly Gln Thr  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Ile  Thr Cys Tyr Val Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Ile Ala Pro Thr Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Thr Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Pro  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Gly Pro Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro Leu Ala  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Ile Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Leu Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Met Val Gln Asp Thr  Leu Asp Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ser Val Tyr Ser  Val Asn Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Asp Ala 
    2900                 2905                 2910             


Phe Ser  Met His Thr Tyr Ser  His His Glu Leu Thr  Arg Val Ala 
    2915                 2920                 2925             


Ser Ala  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Val Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ser  Arg Gly Gly 
    2945                 2950                 2955             


Lys Ala  Ala Val Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Arg  Leu Leu Asp 
    2975                 2980                 2985             


Leu Ser  Ser Trp Phe Thr Val  Gly Ala Gly Gly Gly  Asp Ile Phe 
    2990                 2995                 3000             


His Ser  Val Ser Arg Ala Arg  Pro Arg Ser Leu Leu  Phe Gly Leu 
    3005                 3010                 3015             


Leu Leu  Leu Phe Val Gly Val  Gly Leu Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  77
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  77

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala 
            180                 185                 190         


Glu Val Lys Asn Ile Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Thr 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Val Gly Asn Ala Ser Gln Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Arg 
    370                 375                 380                 


Thr His Thr Val Gly Gly Ser Ala Ala Gln Thr Thr Gly Arg Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Asp Met Gly Pro Arg Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr His Ser Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ser Ala Cys Arg Ser Ile Glu Ala 
    450                 455                 460                 


Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Gln Cys 
                485                 490                 495     


Gly Val Val Ser Ala Lys Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Leu Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Ser 
545                 550                 555                 560 


Gly Tyr Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Phe Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Val Ile Leu His Ala Ala Ser Ala Ala Ser Cys Asn Gly 
        755                 760                 765             


Phe Leu Tyr Phe Val Ile Phe Phe Val Ala Ala Trp Tyr Ile Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Ala Thr Tyr Ser Leu Thr Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Ser Leu Leu Leu Leu Ala Leu Pro Gln Gln Ala Tyr Ala Tyr Asp Ala 
                805                 810                 815     


Ser Val His Gly Gln Ile Gly Ala Ala Leu Leu Val Met Ile Thr Leu 
            820                 825                 830         


Phe Thr Leu Thr Pro Gly Tyr Lys Thr Leu Leu Ser Arg Phe Leu Trp 
        835                 840                 845             


Trp Leu Cys Tyr Leu Leu Thr Leu Gly Glu Ala Met Val Gln Glu Trp 
    850                 855                 860                 


Ala Pro Pro Met Gln Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Ala 
865                 870                 875                 880 


Val Ala Ile Phe Tyr Pro Gly Val Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Val Leu Gly Pro Ala Tyr Leu Leu Lys Gly Ala Leu Thr Arg 
            900                 905                 910         


Val Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Met Cys Thr Met 
        915                 920                 925             


Ala Arg His Leu Ala Gly Gly Arg Tyr Val Gln Met Ala Leu Leu Ala 
    930                 935                 940                 


Leu Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Thr Pro Met 
945                 950                 955                 960 


Ser Asp Trp Ala Ala Ser Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Ile Ile Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Ala Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Ser Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Thr Ile Val Val Ser  Met Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Thr Glu Gln Ala  Gly Glu Ile Gln Val  Leu Ser Thr 
    1055                 1060                 1065             


Val Thr  Gln Ser Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Ser Arg 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Ser Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Glu  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Ala Arg Arg Arg Gly  Asp Lys Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Arg Gly His Ala  Val Gly Val Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ser  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Thr Leu  Asp Ile Val Thr Arg  Ser Pro Thr Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Val Ala Tyr 
    1235                 1240                 1245             


Ala Ala  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Leu Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Ala 
    1280                 1285                 1290             


Pro Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Gly Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Val  Asp Ser Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Thr Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Thr Pro His Pro Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly Gln Glu Gly  Glu Ile Pro Phe Tyr  Gly Arg Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ser Tyr Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Leu Asn Ser Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Val  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Ile Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Thr Gly Glu  Arg Ala Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ser Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Ser Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Val 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ser Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Val Met  Thr Ser Thr Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Val Cys  Ile Ile Gly Arg Leu  His Ile Asn Gln Arg  Ala Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Val Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Arg Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Ile 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Ser Lys  Gln Ala Gln Asp Ile  Gln Pro Thr Val Gln  Ala Ser Trp 
    1745                 1750                 1755             


Pro Lys  Val Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ser Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Leu Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Ile  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Ser Met  Glu Asp Val Val Asn  Leu Leu Pro Gly Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Pro Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Thr  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Leu Leu Gly 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Asn Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Ile Pro  Cys Gly Gly Ser Trp  Leu Arg Asp 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Thr  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Thr  Ser Lys Leu Phe Pro  Lys Met Pro Gly Leu  Pro Phe Val 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Ile 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly Asn Val 
    2030                 2035                 2040             


Arg Leu  Gly Ser Met Arg Ile  Thr Gly Pro Lys Thr  Cys Met Asn 
    2045                 2050                 2055             


Ile Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Gln 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Ala Pro  Asn Phe Lys Val Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Ala  Glu Val Thr Gln His  Gly Ser Tyr 
    2090                 2095                 2100             


His Tyr  Ile Thr Gly Leu Thr  Thr Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Leu  Pro Ser Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Thr  Pro Lys Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Ser  Phe Cys Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Asp Val Leu  Met Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Glu Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Arg Ala Thr Cys Thr  Thr His Gly 
    2210                 2215                 2220             


Lys Ala  Tyr Asp Val Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Gly Ser Lys Val  Val Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Pro Met Val  Glu Glu Arg Ser Asp  Leu Glu Pro 
    2255                 2260                 2265             


Ser Ile  Pro Ser Glu Tyr Met  Leu Pro Lys Lys Arg  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ala Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Ser  Trp Lys Arg Pro Asp  Tyr Gln Pro Ala Thr  Val Ala Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Pro Arg  Lys Thr Pro Thr Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Thr Val Gly Leu  Ser Glu Asp Ser Ile  Gly Asp Ala 
    2330                 2335                 2340             


Leu Gln  Gln Leu Ala Ile Lys  Ser Phe Gly Gln Pro  Pro Pro Ser 
    2345                 2350                 2355             


Gly Asp  Ser Gly Leu Ser Thr  Gly Ala Gly Ala Ala  Asp Ser Gly 
    2360                 2365                 2370             


Ser Gln  Thr Pro Pro Asp Glu  Leu Ala Leu Ser Glu  Thr Gly Ser 
    2375                 2380                 2385             


Ile Ser  Ser Met Pro Pro Leu  Glu Gly Glu Leu Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Pro Glu Gln Val Glu  Pro Gln Pro Pro Pro  Gln Gly Gly 
    2405                 2410                 2415             


Val Ala  Ala Pro Gly Ser Asp  Ser Gly Ser Trp Ser  Thr Cys Ser 
    2420                 2425                 2430             


Glu Glu  Asp Asp Ser Val Val  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Ser Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Leu Arg Tyr  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Cys Thr Thr Thr Lys  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Met Gln  Val Leu Asp Ser Tyr  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Lys Asp Ile Lys Leu  Ala Ala Ser Lys Val  Thr Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Met Glu Glu Ala  Cys Gln Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Arg  Ser Lys Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Gly  Arg Ala Val Asn His  Ile Lys Ser Val Trp  Lys Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Ser Glu Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Val Asp  Pro Thr Lys Gly Gly  Lys Lys Ala 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Thr Gln Lys Leu Pro  Gln Ala Val 
    2615                 2620                 2625             


Met Gly  Ala Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Gln Arg Val 
    2630                 2635                 2640             


Glu Phe  Leu Leu Lys Ala Trp  Ala Glu Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Arg Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Glu Glu  Ala His Thr Ala Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Phe Asn  Ser Lys Gly Gln Thr  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Ile  Thr Cys Tyr Val Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Ile Ala Pro Thr Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Thr Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Pro  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Gly Pro Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro Leu Ala  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Ile Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Leu Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Met Val Gln Asp Thr  Leu Asp Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ser Val Tyr Ser  Val Asn Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Asp Ala 
    2900                 2905                 2910             


Phe Ser  Met His Thr Tyr Ser  His His Glu Leu Thr  Arg Val Ala 
    2915                 2920                 2925             


Ser Ala  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Val Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ser  Arg Gly Gly 
    2945                 2950                 2955             


Lys Ala  Ala Val Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Arg  Leu Leu Asp 
    2975                 2980                 2985             


Leu Ser  Ser Trp Phe Thr Val  Gly Ala Gly Gly Gly  Asp Ile Phe 
    2990                 2995                 3000             


His Ser  Val Ser Arg Ala Arg  Pro Arg Ser Leu Leu  Phe Gly Leu 
    3005                 3010                 3015             


Leu Leu  Leu Phe Val Gly Val  Gly Leu Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  78
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  78

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala 
            180                 185                 190         


Glu Val Lys Asn Ile Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Thr 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Val Gly Asn Ala Ser Gln Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Arg 
    370                 375                 380                 


Thr His Thr Val Gly Gly Ser Ala Ala Gln Thr Thr Gly Arg Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Asp Met Gly Pro Arg Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr His Ser Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ser Ala Cys Arg Ser Ile Glu Ala 
    450                 455                 460                 


Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Gln Cys 
                485                 490                 495     


Gly Val Val Ser Ala Lys Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Leu Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Ser 
545                 550                 555                 560 


Gly Tyr Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Phe Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Val Ile Leu His Ala Ala Ser Ala Ala Ser Cys Asn Gly 
        755                 760                 765             


Phe Leu Tyr Phe Val Ile Phe Ser Val Ala Ala Trp Tyr Ile Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Ala Thr Tyr Ser Leu Thr Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Ser Leu Leu Leu Leu Ala Leu Pro Gln Gln Ala Tyr Ala Tyr Asp Ala 
                805                 810                 815     


Ser Val His Gly Gln Ile Gly Ala Ala Leu Leu Val Met Ile Thr Leu 
            820                 825                 830         


Phe Thr Leu Thr Pro Gly Tyr Lys Thr Leu Leu Ser Arg Phe Leu Trp 
        835                 840                 845             


Trp Leu Cys Tyr Leu Leu Thr Leu Gly Glu Ala Met Val Gln Glu Trp 
    850                 855                 860                 


Ala Pro Pro Met Gln Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Ala 
865                 870                 875                 880 


Val Ala Ile Phe Tyr Pro Gly Val Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Val Leu Gly Pro Ala Tyr Leu Leu Lys Gly Ala Leu Thr Arg 
            900                 905                 910         


Val Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Met Cys Thr Met 
        915                 920                 925             


Ala Arg His Leu Ala Gly Gly Arg Tyr Val Gln Met Ala Leu Leu Ala 
    930                 935                 940                 


Leu Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Thr Pro Met 
945                 950                 955                 960 


Ser Asp Trp Ala Ala Ser Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Ile Ile Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Ala Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Ser Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Thr Ile Val Val Ser  Met Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Thr Glu Gln Ala  Gly Glu Ile Gln Val  Leu Ser Thr 
    1055                 1060                 1065             


Val Thr  Gln Ser Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Ser Arg 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Ser Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Glu  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Ala Arg Arg Arg Gly  Asp Lys Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Arg Gly His Ala  Val Gly Val Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ser  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Thr Leu  Asp Ile Val Thr Arg  Ser Pro Thr Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Val Ala Tyr 
    1235                 1240                 1245             


Ala Ala  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Leu Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Ala 
    1280                 1285                 1290             


Pro Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Gly Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Val  Asp Ser Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Thr Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Thr Pro His Pro Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly Gln Glu Gly  Glu Ile Pro Phe Tyr  Gly Arg Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ser Tyr Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Leu Asn Ser Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Val  Val Asp Phe Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Ile Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Thr Gly Glu  Arg Ala Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ser Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Ser Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Val 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ser Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Val Met  Thr Ser Thr Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ala Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Val Cys  Ile Ile Gly Arg Leu  His Ile Asn Gln Arg  Ala Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Val Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Arg Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Ile 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Ser Lys  Gln Ala Gln Asp Ile  Gln Pro Thr Val Gln  Ala Ser Trp 
    1745                 1750                 1755             


Pro Lys  Val Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ser Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Leu Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Ile  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Ser Met  Glu Asp Val Val Asn  Leu Leu Pro Gly Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Pro Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Thr  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Leu Leu Gly 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Asn Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Ile Pro  Cys Gly Gly Ser Trp  Leu Arg Asp 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Thr  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Thr  Ser Lys Leu Phe Pro  Lys Met Pro Gly Leu  Pro Phe Val 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Ile 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly Asn Val 
    2030                 2035                 2040             


Arg Leu  Gly Ser Met Arg Ile  Thr Gly Pro Lys Thr  Cys Met Asn 
    2045                 2050                 2055             


Ile Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Gln 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Ala Pro  Asn Phe Lys Val Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Ala  Glu Val Thr Gln His  Gly Ser Tyr 
    2090                 2095                 2100             


His Tyr  Ile Thr Gly Leu Thr  Thr Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Leu  Pro Ser Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Thr  Pro Lys Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Ser  Phe Cys Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Asp Val Leu  Met Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Glu Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Arg Ala Thr Cys Thr  Thr His Gly 
    2210                 2215                 2220             


Lys Ala  Tyr Asp Val Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Gly Ser Lys Val  Val Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Pro Met Val  Glu Glu Arg Ser Asp  Leu Glu Pro 
    2255                 2260                 2265             


Ser Ile  Pro Ser Glu Tyr Met  Leu Pro Lys Lys Arg  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ala Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Ser  Trp Lys Arg Pro Asp  Tyr Gln Pro Ala Thr  Val Ala Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Pro Arg  Lys Thr Pro Thr Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Thr Val Gly Leu  Ser Glu Asp Ser Ile  Gly Asp Ala 
    2330                 2335                 2340             


Leu Gln  Gln Leu Ala Ile Lys  Ser Phe Gly Gln Pro  Pro Pro Ser 
    2345                 2350                 2355             


Gly Asp  Ser Gly Leu Ser Thr  Gly Ala Gly Ala Ala  Asp Ser Gly 
    2360                 2365                 2370             


Ser Gln  Thr Pro Pro Asp Glu  Leu Ala Leu Ser Glu  Thr Gly Ser 
    2375                 2380                 2385             


Ile Ser  Ser Met Pro Pro Leu  Glu Gly Glu Leu Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Pro Glu Gln Val Glu  Pro Gln Pro Pro Pro  Gln Gly Gly 
    2405                 2410                 2415             


Val Ala  Ala Pro Gly Ser Asp  Ser Gly Ser Trp Ser  Thr Cys Ser 
    2420                 2425                 2430             


Glu Glu  Asp Asp Ser Val Val  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Ser Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Leu Arg Tyr  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Cys Thr Thr Thr Lys  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Met Gln  Val Leu Asp Ser Tyr  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Lys Asp Ile Lys Leu  Ala Ala Ser Lys Val  Thr Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Met Glu Glu Ala  Cys Gln Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Arg  Ser Lys Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Gly  Arg Ala Val Asn His  Ile Lys Ser Val Trp  Lys Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Ser Glu Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Val Asp  Pro Thr Lys Gly Gly  Lys Lys Ala 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Thr Gln Lys Leu Pro  Gln Ala Val 
    2615                 2620                 2625             


Met Gly  Ala Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Gln Arg Val 
    2630                 2635                 2640             


Glu Phe  Leu Leu Lys Ala Trp  Ala Glu Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Arg Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Glu Glu  Ala His Thr Ala Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Phe Asn  Ser Lys Gly Gln Thr  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Ile  Thr Cys Tyr Val Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Ile Ala Pro Thr Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Thr Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Pro  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Gly Pro Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro Leu Ala  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Ile Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Leu Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Met Val Gln Asp Thr  Leu Asp Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ser Val Tyr Ser  Val Asn Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Asp Ala 
    2900                 2905                 2910             


Phe Ser  Met His Thr Tyr Ser  His His Glu Leu Thr  Arg Val Ala 
    2915                 2920                 2925             


Ser Ala  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Val Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ser  Arg Gly Gly 
    2945                 2950                 2955             


Lys Ala  Ala Val Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Arg  Leu Leu Asp 
    2975                 2980                 2985             


Leu Ser  Ser Trp Phe Thr Val  Gly Ala Gly Gly Gly  Asp Ile Phe 
    2990                 2995                 3000             


His Ser  Val Ser Arg Ala Arg  Pro Arg Ser Leu Leu  Phe Gly Leu 
    3005                 3010                 3015             


Leu Leu  Leu Phe Val Gly Val  Gly Leu Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  79
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  79

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala 
            180                 185                 190         


Glu Val Lys Asn Ile Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Thr 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Val Gly Asn Ala Ser Gln Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Arg 
    370                 375                 380                 


Thr His Thr Val Gly Gly Ser Ala Ala Gln Thr Thr Gly Arg Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Asp Met Gly Pro Arg Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr His Ser Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ser Ala Cys Arg Ser Ile Glu Ala 
    450                 455                 460                 


Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Gln Cys 
                485                 490                 495     


Gly Val Val Ser Ala Lys Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Leu Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Ser 
545                 550                 555                 560 


Gly Tyr Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Phe Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Val Ile Leu His Ala Ala Ser Ala Ala Ser Cys Asn Gly 
        755                 760                 765             


Phe Leu Tyr Phe Val Ile Phe Phe Val Ala Ala Trp Tyr Ile Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Ala Thr Tyr Ser Leu Thr Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Ser Leu Leu Leu Leu Ala Leu Pro Gln Gln Ala Tyr Ala Tyr Asp Ala 
                805                 810                 815     


Ser Val His Gly Gln Ile Gly Ala Ala Leu Leu Val Met Ile Thr Leu 
            820                 825                 830         


Phe Thr Leu Thr Pro Gly Tyr Lys Thr Leu Leu Ser Arg Phe Leu Trp 
        835                 840                 845             


Trp Leu Cys Tyr Leu Leu Thr Leu Gly Glu Ala Met Val Gln Glu Trp 
    850                 855                 860                 


Ala Pro Pro Met Gln Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Ala 
865                 870                 875                 880 


Val Ala Ile Phe Tyr Pro Gly Val Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Val Leu Gly Pro Ala Tyr Leu Leu Lys Gly Ala Leu Thr Arg 
            900                 905                 910         


Val Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Met Cys Thr Met 
        915                 920                 925             


Ala Arg His Leu Ala Gly Gly Arg Tyr Val Gln Met Ala Leu Leu Ala 
    930                 935                 940                 


Leu Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Thr Pro Met 
945                 950                 955                 960 


Ser Asp Trp Ala Ala Ser Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Ile Ile Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Ala Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Ser Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Thr Ile Val Val Ser  Met Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Thr Glu Gln Ala  Gly Glu Ile Gln Val  Leu Ser Thr 
    1055                 1060                 1065             


Val Thr  Gln Ser Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Ser Arg 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Ser Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Glu  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Ala Arg Arg Arg Gly  Asp Lys Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Arg Gly His Ala  Val Gly Val Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ser  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Thr Leu  Asp Ile Val Thr Arg  Ser Pro Thr Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Val Ala Tyr 
    1235                 1240                 1245             


Ala Ala  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Leu Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Ala 
    1280                 1285                 1290             


Pro Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Gly Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Val  Asp Ser Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Thr Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Thr Pro His Pro Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly Gln Glu Gly  Glu Ile Pro Phe Tyr  Gly Arg Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ser Tyr Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Leu Asn Ser Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Val  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Ile Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Thr Gly Glu  Arg Ala Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ser Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Ser Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Val 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ser Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Val Met  Thr Ser Thr Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ala Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Val Cys  Ile Ile Gly Arg Leu  His Ile Asn Gln Arg  Ala Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Val Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Arg Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Ile 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Ser Lys  Gln Ala Gln Asp Ile  Gln Pro Thr Val Gln  Ala Ser Trp 
    1745                 1750                 1755             


Pro Lys  Val Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ser Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Leu Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Ile  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Ser Met  Glu Asp Val Val Asn  Leu Leu Pro Gly Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Pro Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Thr  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Leu Leu Gly 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Asn Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Ile Pro  Cys Gly Gly Ser Trp  Leu Arg Asp 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Thr  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Thr  Ser Lys Leu Phe Pro  Lys Met Pro Gly Leu  Pro Phe Val 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Ile 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly Asn Val 
    2030                 2035                 2040             


Arg Leu  Gly Ser Met Arg Ile  Thr Gly Pro Lys Thr  Cys Met Asn 
    2045                 2050                 2055             


Ile Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Gln 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Ala Pro  Asn Phe Lys Val Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Ala  Glu Val Thr Gln His  Gly Ser Tyr 
    2090                 2095                 2100             


His Tyr  Ile Thr Gly Leu Thr  Thr Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Leu  Pro Ser Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Thr  Pro Lys Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Ser  Phe Cys Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Asp Val Leu  Met Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Glu Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Arg Ala Thr Cys Thr  Thr His Gly 
    2210                 2215                 2220             


Lys Ala  Tyr Asp Val Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Gly Ser Lys Val  Val Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Pro Met Val  Glu Glu Arg Ser Asp  Leu Glu Pro 
    2255                 2260                 2265             


Ser Ile  Pro Ser Glu Tyr Met  Leu Pro Lys Lys Arg  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ala Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Ser  Trp Lys Arg Pro Asp  Tyr Gln Pro Ala Thr  Val Ala Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Pro Arg  Lys Thr Pro Thr Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Thr Val Gly Leu  Ser Glu Asp Ser Ile  Gly Asp Ala 
    2330                 2335                 2340             


Leu Gln  Gln Leu Ala Ile Lys  Ser Phe Gly Gln Pro  Pro Pro Ser 
    2345                 2350                 2355             


Gly Asp  Ser Gly Leu Ser Thr  Gly Ala Gly Ala Ala  Asp Ser Gly 
    2360                 2365                 2370             


Ser Gln  Thr Pro Pro Asp Glu  Leu Ala Leu Ser Glu  Thr Gly Ser 
    2375                 2380                 2385             


Ile Ser  Ser Met Pro Pro Leu  Glu Gly Glu Leu Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Pro Glu Gln Val Glu  Pro Gln Pro Pro Pro  Gln Gly Gly 
    2405                 2410                 2415             


Val Ala  Ala Pro Gly Ser Asp  Ser Gly Ser Trp Ser  Thr Cys Ser 
    2420                 2425                 2430             


Glu Glu  Asp Asp Ser Val Val  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Ser Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Leu Arg Tyr  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Cys Thr Thr Thr Lys  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Met Gln  Val Leu Asp Ser Tyr  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Lys Asp Ile Lys Leu  Ala Ala Ser Lys Val  Thr Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Met Glu Glu Ala  Cys Gln Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Arg  Ser Lys Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Gly  Arg Ala Val Asn His  Ile Lys Ser Val Trp  Lys Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Ser Glu Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Val Asp  Pro Thr Lys Gly Gly  Lys Lys Ala 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Thr Gln Lys Leu Pro  Gln Ala Val 
    2615                 2620                 2625             


Met Gly  Ala Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Gln Arg Val 
    2630                 2635                 2640             


Glu Phe  Leu Leu Lys Ala Trp  Ala Glu Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Arg Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Glu Glu  Ala His Thr Ala Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Phe Asn  Ser Lys Gly Gln Thr  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Ile  Thr Cys Tyr Val Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Ile Ala Pro Thr Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Thr Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Pro  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Gly Pro Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro Leu Ala  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Ile Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Leu Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Met Val Gln Asp Thr  Leu Asp Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ser Val Tyr Ser  Val Asn Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Asp Ala 
    2900                 2905                 2910             


Phe Ser  Met His Thr Tyr Ser  His His Glu Leu Thr  Arg Val Ala 
    2915                 2920                 2925             


Ser Ala  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Val Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ser  Arg Gly Gly 
    2945                 2950                 2955             


Lys Ala  Ala Val Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Arg  Leu Leu Asp 
    2975                 2980                 2985             


Leu Ser  Ser Trp Phe Thr Val  Gly Ala Gly Gly Gly  Asp Ile Phe 
    2990                 2995                 3000             


His Ser  Val Ser Arg Ala Arg  Pro Arg Ser Leu Leu  Phe Gly Leu 
    3005                 3010                 3015             


Leu Leu  Leu Phe Val Gly Val  Gly Leu Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  80
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  80

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala 
            180                 185                 190         


Glu Val Lys Asn Ile Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Thr 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Val Gly Asn Ala Ser Gln Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Arg 
    370                 375                 380                 


Thr His Thr Val Gly Gly Ser Ala Ala Gln Thr Thr Gly Arg Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Asp Met Gly Pro Arg Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr His Ser Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ser Ala Cys Arg Ser Ile Glu Ala 
    450                 455                 460                 


Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Gln Cys 
                485                 490                 495     


Gly Val Val Ser Ala Lys Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Leu Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Ser 
545                 550                 555                 560 


Gly Tyr Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Phe Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Val Ile Leu His Ala Ala Ser Ala Ala Ser Cys Asn Gly 
        755                 760                 765             


Phe Leu Tyr Phe Val Ile Phe Phe Val Ala Ala Trp Tyr Ile Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Ala Thr Tyr Ser Leu Thr Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Ser Leu Leu Leu Leu Ala Leu Pro Gln Gln Ala Tyr Ala Tyr Asp Ala 
                805                 810                 815     


Ser Val His Gly Gln Ile Gly Ala Ala Leu Leu Val Met Ile Thr Leu 
            820                 825                 830         


Phe Thr Leu Thr Pro Gly Tyr Lys Thr Leu Leu Ser Arg Phe Leu Trp 
        835                 840                 845             


Trp Leu Cys Tyr Leu Leu Thr Leu Gly Glu Ala Met Val Gln Glu Trp 
    850                 855                 860                 


Ala Pro Pro Met Gln Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Ala 
865                 870                 875                 880 


Val Ala Ile Phe Tyr Pro Gly Val Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Val Leu Gly Pro Ala Tyr Leu Leu Lys Gly Ala Leu Thr Arg 
            900                 905                 910         


Val Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Met Cys Thr Met 
        915                 920                 925             


Ala Arg His Leu Ala Gly Gly Arg Tyr Val Gln Met Ala Leu Leu Ala 
    930                 935                 940                 


Leu Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Thr Pro Met 
945                 950                 955                 960 


Ser Asp Trp Ala Ala Ser Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Ile Ile Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Ala Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Ser Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Thr Ile Val Val Ser  Met Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Thr Glu Gln Ala  Gly Glu Ile Gln Val  Leu Ser Thr 
    1055                 1060                 1065             


Val Thr  Gln Ser Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Ser Arg 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Ser Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Glu  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Ala Arg Arg Arg Gly  Asp Lys Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Arg Gly His Ala  Val Gly Val Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ser  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Thr Leu  Asp Ile Val Thr Arg  Ser Pro Thr Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Val Ala Tyr 
    1235                 1240                 1245             


Ala Ala  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Leu Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Ala 
    1280                 1285                 1290             


Pro Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Gly Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Val  Asp Ser Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Thr Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Thr Pro His Pro Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly Gln Glu Gly  Glu Ile Pro Phe Tyr  Gly Arg Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ser Tyr Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Leu Asn Ser Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Val  Val Asp Phe Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Ile Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Thr Gly Glu  Arg Ala Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ser Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Ser Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Val 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ser Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Val Met  Thr Ser Thr Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Val Cys  Ile Ile Gly Arg Leu  His Ile Asn Gln Arg  Ala Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Val Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Arg Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Ile 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Ser Lys  Gln Ala Gln Asp Ile  Gln Pro Thr Val Gln  Ala Ser Trp 
    1745                 1750                 1755             


Pro Lys  Val Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ser Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Leu Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Ile  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Ser Met  Glu Asp Val Val Asn  Leu Leu Pro Gly Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Pro Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Thr  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Leu Leu Gly 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Asn Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Ile Pro  Cys Gly Gly Ser Trp  Leu Arg Asp 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Thr  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Thr  Ser Lys Leu Phe Pro  Lys Met Pro Gly Leu  Pro Phe Val 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Ile 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly Asn Val 
    2030                 2035                 2040             


Arg Leu  Gly Ser Met Arg Ile  Thr Gly Pro Lys Thr  Cys Met Asn 
    2045                 2050                 2055             


Ile Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Gln 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Ala Pro  Asn Phe Lys Val Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Ala  Glu Val Thr Gln His  Gly Ser Tyr 
    2090                 2095                 2100             


His Tyr  Ile Thr Gly Leu Thr  Thr Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Leu  Pro Ser Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Thr  Pro Lys Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Ser  Phe Cys Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Asp Val Leu  Met Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Glu Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Arg Ala Thr Cys Thr  Thr His Gly 
    2210                 2215                 2220             


Lys Ala  Tyr Asp Val Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Gly Ser Lys Val  Val Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Pro Met Val  Glu Glu Arg Ser Asp  Leu Glu Pro 
    2255                 2260                 2265             


Ser Ile  Pro Ser Glu Tyr Met  Leu Pro Lys Lys Arg  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ala Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Ser  Trp Lys Arg Pro Asp  Tyr Gln Pro Ala Thr  Val Ala Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Pro Arg  Lys Thr Pro Thr Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Thr Val Gly Leu  Ser Glu Asp Ser Ile  Gly Asp Ala 
    2330                 2335                 2340             


Leu Gln  Gln Leu Ala Ile Lys  Ser Phe Gly Gln Pro  Pro Pro Ser 
    2345                 2350                 2355             


Gly Asp  Ser Gly Leu Ser Thr  Gly Ala Gly Ala Ala  Asp Ser Gly 
    2360                 2365                 2370             


Ser Gln  Thr Pro Pro Asp Glu  Leu Ala Leu Ser Glu  Thr Gly Ser 
    2375                 2380                 2385             


Ile Ser  Ser Met Pro Pro Leu  Glu Gly Glu Leu Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Pro Glu Gln Val Glu  Pro Gln Pro Pro Pro  Gln Gly Gly 
    2405                 2410                 2415             


Val Ala  Ala Pro Gly Ser Asp  Ser Gly Ser Trp Ser  Thr Cys Ser 
    2420                 2425                 2430             


Glu Glu  Asp Asp Ser Val Val  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Ser Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Leu Arg Tyr  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Cys Thr Thr Thr Lys  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Met Gln  Val Leu Asp Ser Tyr  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Lys Asp Ile Lys Leu  Ala Ala Ser Lys Val  Thr Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Met Glu Glu Ala  Cys Gln Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Arg  Ser Lys Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Gly  Arg Ala Val Asn His  Ile Lys Ser Val Trp  Lys Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Ser Glu Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Val Asp  Pro Thr Lys Gly Gly  Lys Lys Ala 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Thr Gln Lys Leu Pro  Gln Ala Val 
    2615                 2620                 2625             


Met Gly  Ala Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Gln Arg Val 
    2630                 2635                 2640             


Glu Phe  Leu Leu Lys Ala Trp  Ala Glu Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Arg Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Glu Glu  Ala His Thr Ala Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Phe Asn  Ser Lys Gly Gln Thr  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Ile  Thr Cys Tyr Val Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Ile Ala Pro Thr Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Thr Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Pro  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Gly Pro Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro Leu Ala  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Ile Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Leu Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Met Val Gln Asp Thr  Leu Asp Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ser Val Tyr Ser  Val Asn Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Asp Ala 
    2900                 2905                 2910             


Phe Ser  Met His Thr Tyr Ser  His His Glu Leu Thr  Arg Val Ala 
    2915                 2920                 2925             


Ser Ala  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Val Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ser  Arg Gly Gly 
    2945                 2950                 2955             


Lys Ala  Ala Val Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Arg  Leu Leu Asp 
    2975                 2980                 2985             


Leu Ser  Ser Trp Phe Thr Val  Gly Ala Gly Gly Gly  Asp Ile Phe 
    2990                 2995                 3000             


His Ser  Val Ser Arg Ala Arg  Pro Arg Ser Leu Leu  Phe Gly Leu 
    3005                 3010                 3015             


Leu Leu  Leu Phe Val Gly Val  Gly Leu Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  81
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  81

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala 
            180                 185                 190         


Glu Val Lys Asn Ile Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Thr 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Val Gly Asn Ala Ser Gln Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Arg 
    370                 375                 380                 


Thr His Thr Val Gly Gly Ser Ala Ala Gln Thr Thr Gly Arg Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Asp Met Gly Pro Arg Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr His Ser Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ser Ala Cys Arg Ser Ile Glu Ala 
    450                 455                 460                 


Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Gln Cys 
                485                 490                 495     


Gly Val Val Ser Ala Lys Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Leu Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Ser 
545                 550                 555                 560 


Gly Tyr Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Phe Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Val Ile Leu His Ala Ala Ser Ala Ala Ser Cys Asn Gly 
        755                 760                 765             


Phe Leu Tyr Phe Val Ile Phe Ser Val Ala Ala Trp Tyr Ile Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Ala Thr Tyr Ser Leu Thr Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Ser Leu Leu Leu Leu Ala Leu Pro Gln Gln Ala Tyr Ala Tyr Asp Ala 
                805                 810                 815     


Ser Val His Gly Gln Ile Gly Ala Ala Leu Leu Val Met Ile Thr Leu 
            820                 825                 830         


Phe Thr Leu Thr Pro Gly Tyr Lys Thr Leu Leu Ser Arg Phe Leu Trp 
        835                 840                 845             


Trp Leu Cys Tyr Leu Leu Thr Leu Gly Glu Ala Met Val Gln Glu Trp 
    850                 855                 860                 


Ala Pro Pro Met Gln Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Ala 
865                 870                 875                 880 


Val Ala Ile Phe Tyr Pro Gly Val Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Val Leu Gly Pro Ala Tyr Leu Leu Lys Gly Ala Leu Thr Arg 
            900                 905                 910         


Val Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Met Cys Thr Met 
        915                 920                 925             


Ala Arg His Leu Ala Gly Gly Arg Tyr Val Gln Met Ala Leu Leu Ala 
    930                 935                 940                 


Leu Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Thr Pro Met 
945                 950                 955                 960 


Ser Asp Trp Ala Ala Ser Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Ile Ile Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Ala Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Ser Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Thr Ile Val Val Ser  Met Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Thr Glu Gln Ala  Gly Glu Ile Gln Val  Leu Ser Thr 
    1055                 1060                 1065             


Val Thr  Gln Ser Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Ser Arg 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Ser Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Glu  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Ala Arg Arg Arg Gly  Asp Lys Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Arg Gly His Ala  Val Gly Val Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ser  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Thr Leu  Asp Ile Val Thr Arg  Ser Pro Thr Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Val Ala Tyr 
    1235                 1240                 1245             


Ala Ala  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Leu Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Ala 
    1280                 1285                 1290             


Pro Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Gly Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Val  Asp Ser Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Thr Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Thr Pro His Pro Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly Gln Glu Gly  Glu Ile Pro Phe Tyr  Gly Arg Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ser Tyr Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Leu Asn Ser Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Val  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Ile Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Thr Gly Glu  Arg Ala Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ser Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Ser Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Val 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ser Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Val Met  Thr Ser Thr Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Val Cys  Ile Ile Gly Arg Leu  His Ile Asn Gln Arg  Ala Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Val Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Arg Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Ile 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Ser Lys  Gln Ala Gln Asp Ile  Gln Pro Thr Val Gln  Ala Ser Trp 
    1745                 1750                 1755             


Pro Lys  Val Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ser Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Leu Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Ile  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Ser Met  Glu Asp Val Val Asn  Leu Leu Pro Gly Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Pro Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Thr  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Leu Leu Gly 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Asn Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Ile Pro  Cys Gly Gly Ser Trp  Leu Arg Asp 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Thr  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Thr  Ser Lys Leu Phe Pro  Lys Met Pro Gly Leu  Pro Phe Val 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Ile 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly Asn Val 
    2030                 2035                 2040             


Arg Leu  Gly Ser Met Arg Ile  Thr Gly Pro Lys Thr  Cys Met Asn 
    2045                 2050                 2055             


Ile Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Gln 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Ala Pro  Asn Phe Lys Val Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Ala  Glu Val Thr Gln His  Gly Ser Tyr 
    2090                 2095                 2100             


His Tyr  Ile Thr Gly Leu Thr  Thr Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Leu  Pro Ser Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Thr  Pro Lys Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Ser  Phe Cys Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Asp Val Leu  Met Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Glu Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Arg Ala Thr Cys Thr  Thr His Gly 
    2210                 2215                 2220             


Lys Ala  Tyr Asp Val Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Gly Ser Lys Val  Val Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Pro Met Val  Glu Glu Arg Ser Asp  Leu Glu Pro 
    2255                 2260                 2265             


Ser Ile  Pro Ser Glu Tyr Met  Leu Pro Lys Lys Arg  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ala Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Ser  Trp Lys Arg Pro Asp  Tyr Gln Pro Ala Thr  Val Ala Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Pro Arg  Lys Thr Pro Thr Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Thr Val Gly Leu  Ser Glu Asp Ser Ile  Gly Asp Ala 
    2330                 2335                 2340             


Leu Gln  Gln Leu Ala Ile Lys  Ser Phe Gly Gln Pro  Pro Pro Ser 
    2345                 2350                 2355             


Gly Asp  Ser Gly Leu Ser Thr  Gly Ala Gly Ala Ala  Asp Ser Gly 
    2360                 2365                 2370             


Ser Gln  Thr Pro Pro Asp Glu  Leu Ala Leu Ser Glu  Thr Gly Ser 
    2375                 2380                 2385             


Ile Ser  Ser Met Pro Pro Leu  Glu Gly Glu Leu Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Pro Glu Gln Val Glu  Pro Gln Pro Pro Pro  Gln Gly Gly 
    2405                 2410                 2415             


Val Ala  Ala Pro Gly Ser Asp  Ser Gly Ser Trp Ser  Thr Cys Ser 
    2420                 2425                 2430             


Glu Glu  Asp Asp Ser Val Val  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Ser Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Leu Arg Tyr  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Cys Thr Thr Thr Lys  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Met Gln  Val Leu Asp Ser Tyr  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Lys Asp Ile Lys Leu  Ala Ala Ser Lys Val  Thr Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Met Glu Glu Ala  Cys Gln Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Arg  Ser Lys Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Gly  Arg Ala Val Asn His  Ile Lys Ser Val Trp  Lys Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Ser Glu Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Val Asp  Pro Thr Lys Gly Gly  Lys Lys Ala 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Thr Gln Lys Leu Pro  Gln Ala Val 
    2615                 2620                 2625             


Met Gly  Ala Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Gln Arg Val 
    2630                 2635                 2640             


Glu Phe  Leu Leu Lys Ala Trp  Ala Glu Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Arg Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Glu Glu  Ala His Thr Ala Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Phe Asn  Ser Lys Gly Gln Thr  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Ile  Thr Cys Tyr Val Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Ile Ala Pro Thr Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Thr Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Pro  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Gly Pro Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro Leu Ala  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Ile Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Leu Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Met Val Gln Asp Thr  Leu Asp Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ser Val Tyr Ser  Val Asn Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Asp Ala 
    2900                 2905                 2910             


Phe Ser  Met His Thr Tyr Ser  His His Glu Leu Thr  Arg Val Ala 
    2915                 2920                 2925             


Ser Ala  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Val Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ser  Arg Gly Gly 
    2945                 2950                 2955             


Lys Ala  Ala Val Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Arg  Leu Leu Asp 
    2975                 2980                 2985             


Leu Ser  Ser Trp Phe Thr Val  Gly Ala Gly Gly Gly  Asp Ile Phe 
    2990                 2995                 3000             


His Ser  Val Ser Arg Ala Arg  Pro Arg Ser Leu Leu  Phe Gly Leu 
    3005                 3010                 3015             


Leu Leu  Leu Phe Val Gly Val  Gly Leu Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  82
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  82

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala 
            180                 185                 190         


Glu Val Lys Asn Ile Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Thr 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Val Gly Asn Ala Ser Gln Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Arg 
    370                 375                 380                 


Thr His Thr Val Gly Gly Ser Ala Ala Gln Thr Thr Gly Arg Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Asp Met Gly Pro Arg Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr His Ser Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ser Ala Cys Arg Ser Ile Glu Ala 
    450                 455                 460                 


Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Gln Cys 
                485                 490                 495     


Gly Val Val Ser Ala Lys Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Leu Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Ser 
545                 550                 555                 560 


Gly Tyr Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Phe Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Val Ile Leu His Ala Ala Ser Ala Ala Ser Cys Asn Gly 
        755                 760                 765             


Phe Leu Tyr Phe Val Ile Phe Ser Val Ala Ala Trp Tyr Ile Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Ala Thr Tyr Ser Leu Thr Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Ser Leu Leu Leu Leu Ala Leu Pro Gln Gln Ala Tyr Ala Tyr Asp Ala 
                805                 810                 815     


Ser Val His Gly Gln Ile Gly Ala Ala Leu Leu Val Met Ile Thr Leu 
            820                 825                 830         


Phe Thr Leu Thr Pro Gly Tyr Lys Thr Leu Leu Ser Arg Phe Leu Trp 
        835                 840                 845             


Trp Leu Cys Tyr Leu Leu Thr Leu Gly Glu Ala Met Val Gln Glu Trp 
    850                 855                 860                 


Ala Pro Pro Met Gln Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Ala 
865                 870                 875                 880 


Val Ala Ile Phe Tyr Pro Gly Val Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Val Leu Gly Pro Ala Tyr Leu Leu Lys Gly Ala Leu Thr Arg 
            900                 905                 910         


Val Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Met Cys Thr Met 
        915                 920                 925             


Ala Arg His Leu Ala Gly Gly Arg Tyr Val Gln Met Ala Leu Leu Ala 
    930                 935                 940                 


Leu Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Thr Pro Met 
945                 950                 955                 960 


Ser Asp Trp Ala Ala Ser Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Ile Ile Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Ala Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Ser Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Thr Ile Val Val Ser  Met Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Thr Glu Gln Ala  Gly Glu Ile Gln Val  Leu Ser Thr 
    1055                 1060                 1065             


Val Thr  Gln Ser Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Ser Arg 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Ser Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Glu  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Ala Arg Arg Arg Gly  Asp Lys Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Arg Gly His Ala  Val Gly Val Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ser  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Thr Leu  Asp Ile Val Thr Arg  Ser Pro Thr Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Val Ala Tyr 
    1235                 1240                 1245             


Ala Ala  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Leu Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Ala 
    1280                 1285                 1290             


Pro Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Gly Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Val  Asp Ser Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Thr Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Thr Pro His Pro Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly Gln Glu Gly  Glu Ile Pro Phe Tyr  Gly Arg Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ser Tyr Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Leu Asn Ser Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Val  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Ile Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Thr Gly Glu  Arg Ala Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ser Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Ser Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Val 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ser Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Val Met  Thr Ser Thr Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Val Cys  Ile Ile Gly Arg Leu  His Ile Asn Gln Arg  Ala Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Val Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Arg Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Ile 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Ser Lys  Gln Ala Gln Asp Ile  Gln Pro Thr Val Gln  Ala Ser Trp 
    1745                 1750                 1755             


Pro Lys  Val Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ser Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Leu Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Ile  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Ser Met  Glu Asp Val Val Asn  Leu Leu Pro Gly Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Pro Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Thr  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Leu Leu Gly 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Asn Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Ile Pro  Cys Gly Gly Ser Trp  Leu Arg Asp 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Thr  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Thr  Ser Lys Leu Phe Pro  Lys Met Pro Gly Leu  Pro Phe Val 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Ile 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly Asn Val 
    2030                 2035                 2040             


Arg Leu  Gly Ser Met Arg Ile  Thr Gly Pro Lys Thr  Cys Met Asn 
    2045                 2050                 2055             


Ile Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Gln 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Ala Pro  Asn Phe Lys Val Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Ala  Glu Val Thr Gln His  Gly Ser Tyr 
    2090                 2095                 2100             


His Tyr  Ile Thr Gly Leu Thr  Thr Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Leu  Pro Ser Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Thr  Pro Lys Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Ser  Phe Cys Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Asp Val Leu  Met Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Glu Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Arg Ala Thr Cys Thr  Thr His Gly 
    2210                 2215                 2220             


Lys Ala  Tyr Asp Val Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Gly Ser Lys Val  Val Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Pro Met Val  Glu Glu Arg Ser Asp  Leu Glu Pro 
    2255                 2260                 2265             


Ser Ile  Pro Ser Glu Tyr Met  Leu Pro Lys Lys Arg  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ala Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Ser  Trp Lys Arg Pro Asp  Tyr Gln Pro Ala Thr  Val Ala Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Pro Arg  Lys Thr Pro Thr Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Thr Val Gly Leu  Ser Glu Asp Ser Ile  Gly Asp Ala 
    2330                 2335                 2340             


Leu Gln  Gln Leu Ala Ile Lys  Ser Phe Gly Gln Pro  Pro Pro Ser 
    2345                 2350                 2355             


Gly Asp  Ser Gly Leu Ser Thr  Gly Ala Gly Ala Ala  Asp Ser Gly 
    2360                 2365                 2370             


Ser Gln  Thr Pro Pro Asp Glu  Leu Ala Leu Ser Glu  Thr Gly Ser 
    2375                 2380                 2385             


Ile Ser  Ser Met Pro Pro Leu  Glu Gly Glu Leu Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Pro Glu Gln Val Glu  Pro Gln Pro Pro Pro  Gln Gly Gly 
    2405                 2410                 2415             


Val Ala  Ala Pro Gly Ser Asp  Ser Gly Ser Trp Ser  Thr Cys Ser 
    2420                 2425                 2430             


Glu Glu  Asp Asp Ser Val Val  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Ser Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Leu Arg Tyr  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Cys Thr Thr Thr Lys  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Met Gln  Val Leu Asp Ser Tyr  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Lys Asp Ile Lys Leu  Ala Ala Ser Lys Val  Thr Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Met Glu Glu Ala  Cys Gln Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Arg  Ser Lys Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Gly  Arg Ala Val Asn His  Ile Lys Ser Val Trp  Lys Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Ser Glu Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Val Asp  Pro Thr Lys Gly Gly  Lys Lys Ala 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Thr Gln Lys Leu Pro  Gln Ala Val 
    2615                 2620                 2625             


Met Gly  Ala Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Gln Arg Val 
    2630                 2635                 2640             


Glu Phe  Leu Leu Lys Ala Trp  Ala Glu Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Arg Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Glu Glu  Ala His Thr Ala Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Phe Asn  Ser Lys Gly Gln Thr  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Ile  Thr Cys Tyr Val Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Ile Ala Pro Thr Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Thr Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Pro  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Gly Pro Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro Leu Ala  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Ile Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Leu Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Met Val Gln Asp Thr  Leu Asp Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ser Val Tyr Ser  Val Asn Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Asp Ala 
    2900                 2905                 2910             


Phe Ser  Met His Thr Tyr Ser  His His Glu Leu Thr  Arg Val Ala 
    2915                 2920                 2925             


Ser Ala  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Val Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ser  Arg Gly Gly 
    2945                 2950                 2955             


Lys Ala  Ala Val Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Arg  Leu Leu Asp 
    2975                 2980                 2985             


Leu Ser  Ser Trp Phe Thr Val  Gly Ala Gly Gly Gly  Asp Ile Tyr 
    2990                 2995                 3000             


His Ser  Val Ser Arg Ala Arg  Pro Arg Leu Leu Leu  Phe Gly Leu 
    3005                 3010                 3015             


Leu Leu  Leu Phe Val Gly Val  Gly Leu Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  83
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  83

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala 
            180                 185                 190         


Glu Val Lys Asn Ile Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Thr 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Val Gly Asn Ala Ser Gln Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Arg 
    370                 375                 380                 


Thr His Thr Val Gly Gly Ser Ala Ala Gln Thr Thr Gly Arg Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Asp Met Gly Pro Arg Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr His Ser Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ser Ala Cys Arg Ser Ile Glu Ala 
    450                 455                 460                 


Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Gln Cys 
                485                 490                 495     


Gly Val Val Ser Ala Lys Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Leu Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Ser 
545                 550                 555                 560 


Gly Tyr Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Phe Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Val Ile Leu His Ala Ala Ser Ala Ala Ser Cys Asn Gly 
        755                 760                 765             


Phe Leu Tyr Phe Val Ile Phe Ser Val Ala Ala Trp Tyr Ile Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Ala Thr Tyr Ser Leu Thr Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Ser Leu Leu Leu Leu Ala Leu Pro Gln Gln Ala Tyr Ala Tyr Asp Ala 
                805                 810                 815     


Ser Val His Gly Gln Ile Gly Ala Ala Leu Leu Val Met Ile Thr Leu 
            820                 825                 830         


Phe Thr Leu Thr Pro Gly Tyr Lys Thr Leu Leu Ser Arg Phe Leu Trp 
        835                 840                 845             


Trp Leu Cys Tyr Leu Leu Thr Leu Gly Glu Ala Met Val Gln Glu Trp 
    850                 855                 860                 


Ala Pro Pro Met Gln Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Ala 
865                 870                 875                 880 


Val Ala Ile Phe Tyr Pro Gly Val Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Val Leu Gly Pro Ala Tyr Leu Leu Lys Gly Ala Leu Thr Arg 
            900                 905                 910         


Val Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Met Cys Thr Met 
        915                 920                 925             


Ala Arg His Leu Ala Gly Gly Arg Tyr Val Gln Met Ala Leu Leu Ala 
    930                 935                 940                 


Leu Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Thr Pro Met 
945                 950                 955                 960 


Ser Asp Trp Ala Ala Ser Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Ile Ile Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Ala Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Ser Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Thr Ile Val Val Ser  Met Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Thr Glu Gln Ala  Gly Glu Ile Gln Val  Leu Ser Thr 
    1055                 1060                 1065             


Val Thr  Gln Ser Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Ser Arg 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Ser Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Glu  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Ala Arg Arg Arg Gly  Asp Lys Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Arg Gly His Ala  Val Gly Val Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ser  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Thr Leu  Asp Ile Val Thr Arg  Ser Pro Thr Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Val Ala Tyr 
    1235                 1240                 1245             


Ala Ala  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Leu Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Ala 
    1280                 1285                 1290             


Pro Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Gly Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Val  Asp Ser Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Thr Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Thr Pro His Pro Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly Gln Glu Gly  Glu Ile Pro Phe Tyr  Gly Arg Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ser Tyr Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Leu Asn Ser Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Val  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Ile Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Thr Gly Glu  Arg Ala Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ser Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Ser Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Val 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ser Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Val Met  Thr Ser Thr Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Val Cys  Ile Ile Gly Arg Leu  His Ile Asn Gln Arg  Ala Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Val Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Arg Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Ile 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Ser Lys  Gln Ala Gln Asp Ile  Gln Pro Thr Val Gln  Ala Ser Trp 
    1745                 1750                 1755             


Pro Lys  Val Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ser Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Leu Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Ile  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Ser Met  Glu Asp Val Val Asn  Leu Leu Pro Gly Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Pro Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Thr  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Leu Leu Gly 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Asn Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Ile Pro  Cys Gly Gly Ser Trp  Leu Arg Asp 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Thr  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Thr  Ser Lys Leu Phe Pro  Lys Met Pro Gly Leu  Pro Phe Val 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Ile 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly Asn Val 
    2030                 2035                 2040             


Arg Leu  Gly Ser Met Arg Ile  Thr Gly Pro Lys Thr  Cys Met Asn 
    2045                 2050                 2055             


Ile Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Gln 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Ala Pro  Asn Phe Lys Val Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Ala  Glu Val Thr Gln His  Gly Ser Tyr 
    2090                 2095                 2100             


His Tyr  Ile Thr Gly Leu Thr  Thr Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Leu  Pro Ser Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Thr  Pro Lys Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Ser  Phe Cys Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Asp Val Leu  Met Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Glu Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Arg Ala Thr Cys Thr  Thr His Gly 
    2210                 2215                 2220             


Lys Ala  Tyr Asp Val Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Gly Ser Lys Val  Val Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Pro Met Val  Glu Glu Arg Ser Asp  Leu Glu Pro 
    2255                 2260                 2265             


Ser Ile  Pro Ser Glu Tyr Met  Leu Pro Lys Lys Arg  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ala Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Ser  Trp Lys Arg Pro Asp  Tyr Gln Pro Ala Thr  Val Ala Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Pro Arg  Lys Thr Pro Thr Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Thr Val Gly Leu  Ser Glu Asp Ser Ile  Gly Asp Ala 
    2330                 2335                 2340             


Leu Gln  Gln Leu Ala Ile Lys  Ser Phe Gly Gln Pro  Pro Pro Ser 
    2345                 2350                 2355             


Gly Asp  Ser Gly Leu Ser Thr  Gly Ala Gly Ala Ala  Asp Ser Gly 
    2360                 2365                 2370             


Ser Gln  Thr Pro Pro Asp Glu  Leu Ala Leu Ser Glu  Thr Gly Ser 
    2375                 2380                 2385             


Ile Ser  Ser Met Pro Pro Leu  Glu Gly Glu Leu Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Pro Glu Gln Val Glu  Pro Gln Pro Pro Pro  Gln Gly Gly 
    2405                 2410                 2415             


Val Ala  Ala Pro Gly Ser Asp  Ser Gly Ser Trp Ser  Thr Cys Ser 
    2420                 2425                 2430             


Glu Glu  Asp Asp Ser Val Val  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Ser Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Leu Arg Tyr  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Cys Thr Thr Thr Lys  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Met Gln  Val Leu Asp Ser Tyr  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Lys Asp Ile Lys Leu  Ala Ala Ser Lys Val  Thr Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Met Glu Glu Ala  Cys Gln Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Arg  Ser Lys Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Gly  Arg Ala Val Asn His  Ile Lys Ser Val Trp  Lys Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Ser Glu Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Val Asp  Pro Thr Lys Gly Gly  Lys Lys Ala 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Thr Gln Lys Leu Pro  Gln Ala Val 
    2615                 2620                 2625             


Met Gly  Ala Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Gln Arg Val 
    2630                 2635                 2640             


Glu Phe  Leu Leu Lys Ala Trp  Ala Glu Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Arg Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Glu Glu  Ala His Thr Ala Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Phe Asn  Ser Lys Gly Gln Thr  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Ile  Thr Cys Tyr Val Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Ile Ala Pro Thr Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Thr Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Pro  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Gly Pro Gln Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Ala  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Ala Arg Met  Val Leu Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Met Ala Gln Asp Thr  Leu Asp Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Ser Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Asp Ala 
    2900                 2905                 2910             


Phe Ser  Met His Thr Tyr Ser  His His Glu Leu Thr  Arg Val Ala 
    2915                 2920                 2925             


Ser Ala  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Val Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ser  Arg Gly Gly 
    2945                 2950                 2955             


Lys Ala  Ala Val Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Arg  Leu Leu Asp 
    2975                 2980                 2985             


Leu Ser  Ser Trp Phe Thr Val  Gly Ala Gly Gly Gly  Asp Ile Phe 
    2990                 2995                 3000             


His Ser  Val Ser Arg Ala Arg  Pro Arg Ser Leu Leu  Phe Gly Leu 
    3005                 3010                 3015             


Leu Leu  Leu Phe Val Gly Val  Gly Leu Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  84
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  84

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala 
            180                 185                 190         


Glu Val Lys Asn Ile Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Thr 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Val Gly Asn Ala Ser Gln Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Arg 
    370                 375                 380                 


Thr His Thr Val Gly Gly Ser Ala Ala Gln Thr Thr Gly Arg Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Asp Met Gly Pro Arg Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr His Ser Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ser Ala Cys Arg Ser Ile Glu Ala 
    450                 455                 460                 


Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Gln Cys 
                485                 490                 495     


Gly Val Val Ser Ala Lys Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Leu Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Ser 
545                 550                 555                 560 


Gly Tyr Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Phe Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Val Ile Leu His Ala Ala Ser Ala Ala Ser Cys Asn Gly 
        755                 760                 765             


Phe Leu Tyr Phe Val Ile Phe Ser Val Ala Ala Trp Tyr Ile Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Ala Thr Tyr Ser Leu Thr Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Ser Leu Leu Leu Leu Ala Leu Pro Gln Gln Ala Tyr Ala Tyr Asp Ala 
                805                 810                 815     


Ser Val His Gly Gln Ile Gly Ala Ala Leu Leu Val Met Ile Thr Leu 
            820                 825                 830         


Phe Thr Leu Thr Pro Gly Tyr Lys Thr Leu Leu Ser Arg Phe Leu Trp 
        835                 840                 845             


Trp Leu Cys Tyr Leu Leu Thr Leu Gly Glu Ala Met Val Gln Glu Trp 
    850                 855                 860                 


Ala Pro Pro Met Gln Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Ala 
865                 870                 875                 880 


Val Ala Ile Phe Tyr Pro Gly Val Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Val Leu Gly Pro Ala Tyr Leu Leu Lys Gly Ala Leu Thr Arg 
            900                 905                 910         


Val Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Met Cys Thr Met 
        915                 920                 925             


Ala Arg His Leu Ala Gly Gly Arg Tyr Val Gln Met Ala Leu Leu Ala 
    930                 935                 940                 


Leu Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Thr Pro Met 
945                 950                 955                 960 


Ser Asp Trp Ala Ala Ser Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Ile Ile Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Ala Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Ser Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Thr Ile Val Val Ser  Met Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Thr Glu Gln Ala  Gly Glu Ile Gln Val  Leu Ser Thr 
    1055                 1060                 1065             


Val Thr  Gln Ser Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Ser Arg 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Ser Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Glu  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Ala Arg Arg Arg Gly  Asp Lys Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Arg Gly His Ala  Val Gly Val Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ser  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Thr Leu  Asp Ile Val Thr Arg  Ser Pro Thr Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Val Ala Tyr 
    1235                 1240                 1245             


Ala Ala  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Leu Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Ala 
    1280                 1285                 1290             


Pro Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Gly Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Val  Asp Ser Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Thr Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Thr Pro His Pro Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly Gln Glu Gly  Glu Ile Pro Phe Tyr  Gly Arg Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ser Tyr Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Leu Asn Ser Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Val  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Ile Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Thr Gly Glu  Arg Ala Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ser Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Ser Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Val 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ser Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Val Met  Thr Ser Thr Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Val Cys  Ile Ile Gly Arg Leu  His Ile Asn Gln Arg  Ala Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Val Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Arg Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Ile 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Ser Lys  Gln Ala Gln Asp Ile  Gln Pro Thr Val Gln  Ala Ser Trp 
    1745                 1750                 1755             


Pro Lys  Val Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ser Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Leu Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Ile  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Ser Met  Glu Asp Val Val Asn  Leu Leu Pro Gly Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Pro Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Thr  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Leu Leu Gly 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Asn Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Ile Pro  Cys Gly Gly Ser Trp  Leu Arg Asp 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Thr  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Thr  Ser Lys Leu Phe Pro  Lys Met Pro Gly Leu  Pro Phe Val 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Ile 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly Asn Val 
    2030                 2035                 2040             


Arg Leu  Gly Ser Met Arg Ile  Thr Gly Pro Lys Thr  Cys Met Asn 
    2045                 2050                 2055             


Ile Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Gln 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Ala Pro  Asn Phe Lys Val Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Ala  Glu Val Thr Gln His  Gly Ser Tyr 
    2090                 2095                 2100             


His Tyr  Ile Thr Gly Leu Thr  Thr Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Leu  Pro Ser Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Thr  Pro Lys Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Ser  Phe Cys Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Asp Val Leu  Met Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Glu Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Arg Ala Thr Cys Thr  Thr His Gly 
    2210                 2215                 2220             


Lys Ala  Tyr Asp Val Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Gly Ser Lys Val  Val Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Pro Met Val  Glu Glu Arg Ser Asp  Leu Glu Pro 
    2255                 2260                 2265             


Ser Ile  Pro Ser Glu Tyr Met  Leu Pro Lys Lys Arg  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ala Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Ser  Trp Lys Arg Pro Asp  Tyr Gln Pro Ala Thr  Val Ala Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Pro Arg  Lys Thr Pro Thr Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Thr Val Gly Leu  Ser Glu Asp Ser Ile  Gly Asp Ala 
    2330                 2335                 2340             


Leu Gln  Gln Leu Ala Ile Lys  Ser Phe Gly Gln Pro  Pro Pro Ser 
    2345                 2350                 2355             


Gly Asp  Ser Gly Leu Ser Thr  Gly Ala Gly Ala Ala  Asp Ser Gly 
    2360                 2365                 2370             


Ser Gln  Thr Pro Pro Asp Glu  Leu Ala Leu Ser Glu  Thr Gly Ser 
    2375                 2380                 2385             


Ile Ser  Ser Met Pro Pro Leu  Glu Gly Glu Leu Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Pro Glu Gln Val Glu  Pro Gln Pro Pro Pro  Gln Gly Gly 
    2405                 2410                 2415             


Val Ala  Ala Pro Gly Ser Asp  Ser Gly Ser Trp Ser  Thr Cys Ser 
    2420                 2425                 2430             


Glu Glu  Asp Asp Ser Val Val  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Ser Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Leu Arg Tyr  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Cys Thr Thr Thr Lys  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Met Gln  Val Leu Asp Ser Tyr  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Lys Asp Ile Lys Leu  Ala Ala Ser Lys Val  Thr Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Met Glu Glu Ala  Cys Gln Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Arg  Ser Lys Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Gly  Arg Ala Val Asn His  Ile Lys Ser Val Trp  Lys Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Ser Glu Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Val Asp  Pro Thr Lys Gly Gly  Lys Lys Ala 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Thr Gln Lys Leu Pro  Gln Ala Val 
    2615                 2620                 2625             


Met Gly  Ala Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Gln Arg Val 
    2630                 2635                 2640             


Glu Phe  Leu Leu Lys Ala Trp  Ala Glu Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Arg Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Glu Glu  Ala His Thr Ala Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Phe Asn  Ser Lys Gly Gln Thr  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Ile  Thr Cys Tyr Val Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Ile Ala Pro Thr Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Thr Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Pro  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Gly Pro Gln Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Ala  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Ala Arg Met  Val Leu Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Met Ala Gln Asp Thr  Leu Asp Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Ser Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Asp Ala 
    2900                 2905                 2910             


Phe Ser  Met His Thr Tyr Ser  His His Glu Leu Thr  Arg Val Ala 
    2915                 2920                 2925             


Ser Ala  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Val Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ser  Arg Gly Gly 
    2945                 2950                 2955             


Lys Ala  Ala Val Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Arg  Leu Leu Asp 
    2975                 2980                 2985             


Leu Ser  Ser Trp Phe Thr Val  Gly Ala Gly Gly Gly  Asp Ile Tyr 
    2990                 2995                 3000             


His Ser  Val Ser Arg Ala Arg  Pro Arg Leu Leu Leu  Phe Gly Leu 
    3005                 3010                 3015             


Leu Leu  Leu Phe Val Gly Val  Gly Leu Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  85
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  85

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala 
            180                 185                 190         


Glu Val Lys Asn Ile Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Thr 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Val Gly Asn Ala Ser Gln Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Arg 
    370                 375                 380                 


Thr His Thr Val Gly Gly Ser Ala Ala Gln Thr Thr Gly Arg Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Asp Met Gly Pro Arg Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr His Ser Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ser Ala Cys Arg Ser Ile Glu Ala 
    450                 455                 460                 


Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Gln Cys 
                485                 490                 495     


Gly Val Val Ser Ala Lys Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Leu Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Ser 
545                 550                 555                 560 


Gly Tyr Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Phe Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Val Ile Leu His Ala Ala Ser Ala Ala Ser Cys Asn Gly 
        755                 760                 765             


Phe Leu Tyr Phe Val Ile Phe Ser Val Ala Ala Trp Tyr Ile Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Ala Thr Tyr Ser Leu Thr Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Ser Leu Leu Leu Leu Ala Leu Pro Gln Gln Ala Tyr Ala Tyr Asp Ala 
                805                 810                 815     


Ser Val His Gly Gln Ile Gly Ala Ala Leu Leu Val Met Ile Thr Leu 
            820                 825                 830         


Phe Thr Leu Thr Pro Gly Tyr Lys Thr Leu Leu Ser Arg Phe Leu Trp 
        835                 840                 845             


Trp Leu Cys Tyr Leu Leu Thr Leu Gly Glu Ala Met Val Gln Glu Trp 
    850                 855                 860                 


Ala Pro Pro Met Gln Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Ala 
865                 870                 875                 880 


Val Ala Ile Phe Tyr Pro Gly Val Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Val Leu Gly Pro Ala Tyr Leu Leu Lys Gly Ala Leu Thr Arg 
            900                 905                 910         


Val Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Met Cys Thr Met 
        915                 920                 925             


Ala Arg His Leu Ala Gly Gly Arg Tyr Val Gln Met Ala Leu Leu Ala 
    930                 935                 940                 


Leu Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Thr Pro Met 
945                 950                 955                 960 


Ser Asp Trp Ala Ala Ser Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Ile Ile Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Ala Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Ser Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Thr Ile Val Val Ser  Met Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Thr Glu Gln Ala  Gly Glu Ile Gln Val  Leu Ser Thr 
    1055                 1060                 1065             


Val Thr  Gln Ser Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Ser Arg 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Ser Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Glu  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Ala Arg Arg Arg Gly  Asp Lys Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Arg Gly His Ala  Val Gly Val Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ser  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Thr Leu  Asp Ile Val Thr Arg  Ser Pro Thr Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Val Ala Tyr 
    1235                 1240                 1245             


Ala Ala  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Leu Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Ala 
    1280                 1285                 1290             


Pro Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Gly Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Val  Asp Ser Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Thr Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Thr Pro His Pro Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly Gln Glu Gly  Glu Ile Pro Phe Tyr  Gly Arg Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ser Tyr Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Leu Asn Ser Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Val  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Ile Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Thr Gly Glu  Arg Ala Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ser Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Ser Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Val 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ser Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Val Met  Thr Ser Thr Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Val Cys  Ile Ile Gly Arg Leu  His Ile Asn Gln Arg  Ala Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Val Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Arg Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Ile 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Ser Lys  Gln Ala Gln Asp Ile  Gln Pro Thr Val Gln  Ala Ser Trp 
    1745                 1750                 1755             


Pro Lys  Val Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ser Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Leu Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Ile  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Ser Met  Glu Asp Val Val Asn  Leu Leu Pro Gly Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Pro Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Thr  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Leu Leu Gly 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Asn Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Ile Pro  Cys Gly Gly Ser Trp  Leu Arg Asp 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Thr  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Thr  Ser Lys Leu Phe Pro  Lys Met Pro Gly Leu  Pro Phe Val 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Ile 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly Asn Val 
    2030                 2035                 2040             


Arg Leu  Gly Ser Met Arg Ile  Thr Gly Pro Lys Thr  Cys Met Asn 
    2045                 2050                 2055             


Ile Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Gln 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Ala Pro  Asn Phe Lys Val Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Ala  Glu Val Thr Gln His  Gly Ser Tyr 
    2090                 2095                 2100             


His Tyr  Ile Thr Gly Leu Thr  Thr Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Leu  Pro Ser Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Thr  Pro Lys Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Ser  Phe Cys Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Asp Val Leu  Met Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Glu Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Arg Ala Thr Cys Thr  Thr His Gly 
    2210                 2215                 2220             


Lys Ala  Tyr Asp Val Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Gly Ser Lys Val  Val Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Pro Met Val  Glu Glu Arg Ser Asp  Leu Glu Pro 
    2255                 2260                 2265             


Ser Ile  Pro Ser Glu Tyr Met  Leu Pro Lys Lys Arg  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ala Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Ser  Trp Lys Arg Pro Asp  Tyr Gln Pro Ala Thr  Val Ala Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Pro Arg  Lys Thr Pro Thr Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Thr Val Gly Leu  Ser Glu Asp Ser Ile  Gly Asp Ala 
    2330                 2335                 2340             


Leu Gln  Gln Leu Ala Ile Lys  Ser Phe Gly Gln Pro  Pro Pro Ser 
    2345                 2350                 2355             


Gly Asp  Ser Gly Leu Ser Thr  Gly Ala Gly Ala Ala  Asp Ser Gly 
    2360                 2365                 2370             


Ser Gln  Thr Pro Pro Asp Glu  Leu Ala Leu Ser Glu  Thr Gly Ser 
    2375                 2380                 2385             


Ile Ser  Ser Met Pro Pro Leu  Glu Gly Glu Leu Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Pro Glu Gln Val Glu  Pro Gln Pro Pro Pro  Gln Gly Gly 
    2405                 2410                 2415             


Val Ala  Ala Pro Gly Ser Asp  Ser Gly Ser Trp Ser  Thr Cys Ser 
    2420                 2425                 2430             


Glu Glu  Asp Asp Ser Val Val  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Ser Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Leu Arg Tyr  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Cys Thr Thr Thr Lys  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Met Gln  Val Leu Asp Ser Tyr  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Lys Asp Ile Lys Leu  Ala Ala Ser Lys Val  Thr Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Met Glu Glu Ala  Cys Gln Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Arg  Ser Lys Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Gly  Arg Ala Val Asn His  Ile Lys Ser Val Trp  Lys Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Ser Glu Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Val Asp  Pro Thr Lys Gly Gly  Lys Lys Ala 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Thr Gln Lys Leu Pro  Gln Ala Val 
    2615                 2620                 2625             


Met Gly  Ala Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Gln Arg Val 
    2630                 2635                 2640             


Glu Phe  Leu Leu Lys Ala Trp  Ala Glu Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Arg Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Glu Glu  Ala His Thr Ala Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Phe Asn  Ser Lys Gly Gln Thr  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Ile  Thr Cys Tyr Val Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Ile Ala Pro Thr Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Thr Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Pro  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Gly Pro Gln Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Ala  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Ala Arg Met  Val Leu Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Met Ala Gln Asp Thr  Leu Asp Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Ser Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Asp Ala 
    2900                 2905                 2910             


Phe Ser  Met His Thr Tyr Thr  His His Glu Leu Thr  Arg Val Ala 
    2915                 2920                 2925             


Ser Ala  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ser  Arg Gly Gly 
    2945                 2950                 2955             


Lys Ala  Ala Val Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Arg  Leu Leu Asp 
    2975                 2980                 2985             


Leu Ser  Ser Trp Phe Thr Val  Gly Ala Gly Gly Gly  Asp Ile Phe 
    2990                 2995                 3000             


His Ser  Val Ser Arg Ala Arg  Pro Arg Leu Leu Leu  Phe Gly Leu 
    3005                 3010                 3015             


Leu Leu  Leu Phe Val Gly Val  Gly Leu Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  86
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  86

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala 
            180                 185                 190         


Glu Val Lys Asn Ile Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Thr 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Val Gly Asn Ala Ser Gln Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Arg 
    370                 375                 380                 


Thr His Thr Val Gly Gly Ser Ala Ala Gln Thr Thr Gly Arg Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Asp Met Gly Pro Arg Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr His Ser Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ser Ala Cys Arg Ser Ile Glu Ala 
    450                 455                 460                 


Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Gln Cys 
                485                 490                 495     


Gly Val Val Ser Ala Lys Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Leu Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Ser 
545                 550                 555                 560 


Gly Tyr Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Phe Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Val Ile Leu His Ala Ala Ser Ala Ala Ser Cys Asn Gly 
        755                 760                 765             


Phe Leu Tyr Phe Val Ile Phe Ser Val Ala Ala Trp Tyr Ile Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Ala Thr Tyr Ser Leu Thr Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Ser Leu Leu Leu Leu Ala Leu Pro Gln Gln Ala Tyr Ala Tyr Asp Ala 
                805                 810                 815     


Ser Val His Gly Gln Ile Gly Ala Ala Leu Leu Val Met Ile Thr Leu 
            820                 825                 830         


Phe Thr Leu Thr Pro Gly Tyr Lys Thr Leu Leu Ser Arg Phe Leu Trp 
        835                 840                 845             


Trp Leu Cys Tyr Leu Leu Thr Leu Gly Glu Ala Met Val Gln Glu Trp 
    850                 855                 860                 


Ala Pro Pro Met Gln Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Ala 
865                 870                 875                 880 


Val Ala Ile Phe Tyr Pro Gly Val Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Val Leu Gly Pro Ala Tyr Leu Leu Lys Gly Ala Leu Thr Arg 
            900                 905                 910         


Val Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Met Cys Thr Met 
        915                 920                 925             


Ala Arg His Leu Ala Gly Gly Arg Tyr Val Gln Met Ala Leu Leu Ala 
    930                 935                 940                 


Leu Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Thr Pro Met 
945                 950                 955                 960 


Ser Asp Trp Ala Ala Ser Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Ile Ile Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Ala Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Ser Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Thr Ile Val Val Ser  Met Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Thr Glu Gln Ala  Gly Glu Ile Gln Val  Leu Ser Thr 
    1055                 1060                 1065             


Val Thr  Gln Ser Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Ser Arg 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Ser Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Glu  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Ala Arg Arg Arg Gly  Asp Lys Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Arg Gly His Ala  Val Gly Val Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ser  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Thr Leu  Asp Ile Val Thr Arg  Ser Pro Thr Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Val Ala Tyr 
    1235                 1240                 1245             


Ala Ala  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Leu Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Ala 
    1280                 1285                 1290             


Pro Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Gly Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Val  Asp Ser Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Thr Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Thr Pro His Pro Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly Gln Glu Gly  Glu Ile Pro Phe Tyr  Gly Arg Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ser Tyr Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Leu Asn Ser Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Val  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Ile Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Thr Gly Glu  Arg Ala Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ser Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Ser Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Val 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ser Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Val Met  Thr Ser Thr Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Val Cys  Ile Ile Gly Arg Leu  His Ile Asn Gln Arg  Ala Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Val Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Arg Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Ile 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Ser Lys  Gln Ala Gln Asp Ile  Gln Pro Thr Val Gln  Ala Ser Trp 
    1745                 1750                 1755             


Pro Lys  Val Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ser Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Leu Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Ile  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Ser Met  Glu Asp Val Val Asn  Leu Leu Pro Gly Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Pro Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Thr  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Leu Leu Gly 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Asn Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Ile Pro  Cys Gly Gly Ser Trp  Leu Arg Asp 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Thr  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Thr  Ser Lys Leu Phe Pro  Lys Met Pro Gly Leu  Pro Phe Val 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Ile 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly Asn Val 
    2030                 2035                 2040             


Arg Leu  Gly Ser Met Arg Ile  Thr Gly Pro Lys Thr  Cys Met Asn 
    2045                 2050                 2055             


Ile Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Gln 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Ala Pro  Asn Phe Lys Val Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Ala  Glu Val Thr Gln His  Gly Ser Tyr 
    2090                 2095                 2100             


His Tyr  Ile Thr Gly Leu Thr  Thr Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Leu  Pro Ser Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Thr  Pro Lys Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Ser  Phe Cys Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Asp Val Leu  Met Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Glu Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Arg Ala Thr Cys Thr  Thr His Gly 
    2210                 2215                 2220             


Lys Ala  Tyr Asp Val Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Gly Ser Lys Val  Val Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Pro Met Val  Glu Glu Arg Ser Asp  Leu Glu Pro 
    2255                 2260                 2265             


Ser Ile  Pro Ser Glu Tyr Met  Leu Pro Lys Lys Arg  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ala Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Ser  Trp Lys Arg Pro Asp  Tyr Gln Pro Ala Thr  Val Ala Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Pro Arg  Lys Thr Pro Thr Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Thr Val Gly Leu  Ser Glu Asp Ser Ile  Gly Asp Ala 
    2330                 2335                 2340             


Leu Gln  Gln Leu Ala Ile Lys  Ser Phe Gly Gln Pro  Pro Pro Ser 
    2345                 2350                 2355             


Gly Asp  Ser Gly Leu Ser Thr  Gly Ala Gly Ala Ala  Asp Ser Gly 
    2360                 2365                 2370             


Ser Gln  Thr Pro Pro Asp Glu  Leu Ala Leu Ser Glu  Thr Gly Ser 
    2375                 2380                 2385             


Ile Ser  Ser Met Pro Pro Leu  Glu Gly Glu Leu Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Pro Glu Gln Val Glu  Pro Gln Pro Pro Pro  Gln Gly Gly 
    2405                 2410                 2415             


Val Ala  Ala Pro Gly Ser Asp  Ser Gly Ser Trp Ser  Thr Cys Ser 
    2420                 2425                 2430             


Glu Glu  Asp Asp Ser Val Val  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Ser Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Leu Arg Tyr  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Cys Thr Thr Thr Lys  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Met Gln  Val Leu Asp Ser Tyr  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Lys Asp Ile Lys Leu  Ala Ala Ser Lys Val  Thr Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Met Glu Glu Ala  Cys Gln Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Arg  Ser Lys Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Gly  Arg Ala Val Asn His  Ile Lys Ser Val Trp  Lys Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Ser Glu Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Val Asp  Pro Thr Lys Gly Gly  Lys Lys Ala 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Thr Gln Lys Leu Pro  Gln Ala Val 
    2615                 2620                 2625             


Met Gly  Ala Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Gln Arg Val 
    2630                 2635                 2640             


Glu Phe  Leu Leu Lys Ala Trp  Ala Glu Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Arg Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Glu Glu  Ala His Thr Ala Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Phe Asn  Ser Lys Gly Gln Thr  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Ile  Thr Cys Tyr Val Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Ile Ala Pro Thr Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Thr Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Pro  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Gly Pro Gln Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Ala  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Ala Arg Met  Val Leu Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Met Ala Gln Asp Thr  Leu Asp Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Ser Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Asp Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Thr  Pro His Glu Leu Thr  Arg Val Ala 
    2915                 2920                 2925             


Ser Ala  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ser  Arg Gly Gly 
    2945                 2950                 2955             


Arg Ala  Ala Val Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Arg  Leu Leu Asp 
    2975                 2980                 2985             


Leu Ser  Ser Trp Phe Thr Val  Gly Ala Gly Gly Gly  Asp Ile Phe 
    2990                 2995                 3000             


His Ser  Val Ser Arg Ala Arg  Pro Arg Leu Leu Leu  Phe Gly Leu 
    3005                 3010                 3015             


Leu Leu  Leu Phe Val Gly Val  Gly Leu Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  87
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  87

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala 
            180                 185                 190         


Glu Val Lys Asn Ile Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Thr 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Val Gly Asn Ala Ser Gln Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Arg 
    370                 375                 380                 


Thr His Thr Val Gly Gly Ser Ala Ala Gln Thr Thr Gly Arg Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Asp Met Gly Pro Arg Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr His Ser Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ser Ala Cys Arg Ser Ile Glu Ala 
    450                 455                 460                 


Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Gln Cys 
                485                 490                 495     


Gly Val Val Ser Ala Lys Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Leu Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Ser 
545                 550                 555                 560 


Gly Tyr Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Phe Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Val Ile Leu His Ala Ala Ser Ala Ala Ser Cys Asn Gly 
        755                 760                 765             


Phe Leu Tyr Phe Val Ile Phe Phe Val Ala Ala Trp Tyr Ile Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Ala Thr Tyr Ser Leu Thr Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Ser Leu Leu Leu Leu Ala Leu Pro Gln Gln Ala Tyr Ala Tyr Asp Ala 
                805                 810                 815     


Ser Val His Gly Gln Ile Gly Ala Ala Leu Leu Val Met Ile Thr Leu 
            820                 825                 830         


Phe Thr Leu Thr Pro Gly Tyr Lys Thr Leu Leu Ser Arg Phe Leu Trp 
        835                 840                 845             


Trp Leu Cys Tyr Leu Leu Thr Leu Gly Glu Ala Met Val Gln Glu Trp 
    850                 855                 860                 


Ala Pro Pro Met Gln Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Ala 
865                 870                 875                 880 


Val Ala Ile Phe Tyr Pro Gly Val Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Val Leu Gly Pro Ala Tyr Leu Leu Lys Gly Ala Leu Thr Arg 
            900                 905                 910         


Val Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Met Cys Thr Met 
        915                 920                 925             


Ala Arg His Leu Ala Gly Gly Arg Tyr Val Gln Met Ala Leu Leu Ala 
    930                 935                 940                 


Leu Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Thr Pro Met 
945                 950                 955                 960 


Ser Asp Trp Ala Ala Ser Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Ile Ile Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Ala Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Ser Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Thr Ile Val Val Ser  Met Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Thr Glu Gln Ala  Gly Glu Ile Gln Val  Leu Ser Thr 
    1055                 1060                 1065             


Val Thr  Gln Ser Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Ser Arg 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Ser Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Glu  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Ala Arg Arg Arg Gly  Asp Lys Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Arg Gly His Ala  Val Gly Val Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ser  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Thr Leu  Asp Ile Val Thr Arg  Ser Pro Thr Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Val Ala Tyr 
    1235                 1240                 1245             


Ala Ala  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Leu Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Ala 
    1280                 1285                 1290             


Pro Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Gly Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Val  Asp Ser Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Thr Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Thr Pro His Pro Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly Gln Glu Gly  Glu Ile Pro Phe Tyr  Gly Arg Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ser Tyr Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Leu Asn Ser Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Val  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Ile Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Thr Gly Glu  Arg Ala Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ser Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Ser Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Val 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ser Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Val Met  Thr Ser Thr Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Val Cys  Ile Ile Gly Arg Leu  His Ile Asn Gln Arg  Ala Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Val Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Arg Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Ile 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Ser Lys  Gln Ala Gln Asp Ile  Gln Pro Thr Val Gln  Ala Ser Trp 
    1745                 1750                 1755             


Pro Lys  Val Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ser Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Leu Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Ile  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Ser Met  Glu Asp Val Val Asn  Leu Leu Pro Gly Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Pro Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Thr  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Leu Leu Gly 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Asn Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Ile Pro  Cys Gly Gly Ser Trp  Leu Arg Asp 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Thr  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Thr  Ser Lys Leu Phe Pro  Lys Met Pro Gly Leu  Pro Phe Val 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Ile 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly Asn Val 
    2030                 2035                 2040             


Arg Leu  Gly Ser Met Arg Ile  Thr Gly Pro Lys Thr  Cys Met Asn 
    2045                 2050                 2055             


Ile Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Gln 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Ala Pro  Asn Phe Lys Val Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Ala  Glu Val Thr Gln His  Gly Ser Tyr 
    2090                 2095                 2100             


His Tyr  Ile Thr Gly Leu Thr  Thr Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Leu  Pro Ser Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Thr  Pro Lys Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Ser  Phe Cys Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Asp Val Leu  Met Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Glu Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Arg Ala Thr Cys Thr  Thr His Gly 
    2210                 2215                 2220             


Lys Ala  Tyr Asp Val Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Gly Ser Lys Val  Val Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Pro Met Val  Glu Glu Arg Ser Asp  Leu Glu Pro 
    2255                 2260                 2265             


Ser Ile  Pro Ser Glu Tyr Met  Leu Pro Lys Lys Arg  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ala Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Ser  Trp Lys Arg Pro Asp  Tyr Gln Pro Ala Thr  Val Ala Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Pro Arg  Lys Thr Pro Thr Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Thr Val Gly Leu  Ser Glu Asp Ser Ile  Gly Asp Ala 
    2330                 2335                 2340             


Leu Gln  Gln Leu Ala Ile Lys  Ser Phe Gly Gln Pro  Pro Pro Ser 
    2345                 2350                 2355             


Gly Asp  Ser Gly Leu Ser Thr  Gly Ala Gly Ala Ala  Asp Ser Gly 
    2360                 2365                 2370             


Ser Gln  Thr Pro Pro Asp Glu  Leu Ala Leu Ser Glu  Thr Gly Ser 
    2375                 2380                 2385             


Ile Ser  Ser Met Pro Pro Leu  Glu Gly Glu Leu Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Pro Glu Gln Val Glu  Pro Gln Pro Pro Pro  Gln Gly Gly 
    2405                 2410                 2415             


Val Ala  Ala Pro Gly Ser Asp  Ser Gly Ser Trp Ser  Thr Cys Ser 
    2420                 2425                 2430             


Glu Glu  Asp Asp Ser Val Val  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Ser Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Leu Arg Tyr  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Cys Thr Thr Thr Lys  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Met Gln  Val Leu Asp Ser Tyr  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Lys Asp Ile Lys Leu  Ala Ala Ser Lys Val  Thr Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Met Glu Glu Ala  Cys Gln Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Arg  Ser Lys Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Gly  Arg Ala Val Asn His  Ile Lys Ser Val Trp  Lys Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Ser Glu Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Val Asp  Pro Thr Lys Gly Gly  Lys Lys Ala 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Thr Gln Lys Leu Pro  Gln Ala Val 
    2615                 2620                 2625             


Met Gly  Ala Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Gln Arg Val 
    2630                 2635                 2640             


Glu Phe  Leu Leu Lys Ala Trp  Ala Glu Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Arg Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Glu Glu  Ala His Thr Ala Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Phe Asn  Ser Lys Gly Gln Thr  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Ile  Thr Cys Tyr Val Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Ile Ala Pro Thr Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Thr Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Pro  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Gly Pro Gln Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Ala  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Ala Arg Met  Val Leu Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Met Ala Gln Asp Thr  Leu Asp Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Ser Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Asp Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Thr  Pro His Glu Leu Thr  Arg Val Ala 
    2915                 2920                 2925             


Ser Ala  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ser  Arg Gly Gly 
    2945                 2950                 2955             


Arg Ala  Ala Val Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Arg  Leu Leu Asp 
    2975                 2980                 2985             


Leu Ser  Ser Trp Phe Thr Val  Gly Ala Gly Gly Gly  Asp Ile Phe 
    2990                 2995                 3000             


His Ser  Val Ser Arg Ala Arg  Pro Arg Leu Leu Leu  Phe Gly Leu 
    3005                 3010                 3015             


Leu Leu  Leu Phe Val Gly Val  Gly Leu Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  88
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  88

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala 
            180                 185                 190         


Glu Val Lys Asn Ile Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Thr 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Val Gly Asn Ala Ser Gln Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Arg 
    370                 375                 380                 


Thr His Thr Val Gly Gly Ser Ala Ala Gln Thr Thr Gly Arg Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Asp Met Gly Pro Arg Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr His Ser Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ser Ala Cys Arg Ser Ile Glu Ala 
    450                 455                 460                 


Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Gln Cys 
                485                 490                 495     


Gly Val Val Ser Ala Lys Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Leu Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Ser 
545                 550                 555                 560 


Gly Tyr Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Phe Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Val Ile Leu His Ala Ala Ser Ala Ala Ser Cys Asn Gly 
        755                 760                 765             


Phe Leu Tyr Phe Val Ile Phe Phe Val Ala Ala Trp Tyr Ile Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Ala Thr Tyr Ser Leu Thr Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Ser Leu Leu Leu Leu Ala Leu Pro Gln Gln Ala Tyr Ala Tyr Asp Ala 
                805                 810                 815     


Ser Val His Gly Gln Ile Gly Ala Ala Leu Leu Val Met Ile Thr Leu 
            820                 825                 830         


Phe Thr Leu Thr Pro Gly Tyr Lys Thr Leu Leu Ser Arg Phe Leu Trp 
        835                 840                 845             


Trp Leu Cys Tyr Leu Leu Thr Leu Gly Glu Ala Met Val Gln Glu Trp 
    850                 855                 860                 


Ala Pro Pro Met Gln Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Ala 
865                 870                 875                 880 


Val Ala Ile Phe Tyr Pro Gly Val Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Val Leu Gly Pro Ala Tyr Leu Leu Lys Gly Ala Leu Thr Arg 
            900                 905                 910         


Val Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Met Cys Thr Met 
        915                 920                 925             


Ala Arg His Leu Ala Gly Gly Arg Tyr Val Gln Met Ala Leu Leu Ala 
    930                 935                 940                 


Leu Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Thr Pro Met 
945                 950                 955                 960 


Ser Asp Trp Ala Ala Ser Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Ile Ile Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Ala Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Ser Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Thr Ile Val Val Ser  Met Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Thr Glu Gln Ala  Gly Glu Ile Gln Val  Leu Ser Thr 
    1055                 1060                 1065             


Val Thr  Gln Ser Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Ser Arg 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Ser Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Glu  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Ala Arg Arg Arg Gly  Asp Lys Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Arg Gly His Ala  Val Gly Val Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ser  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Thr Leu  Asp Ile Val Thr Arg  Ser Pro Thr Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Val Ala Tyr 
    1235                 1240                 1245             


Ala Ala  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Leu Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Ala 
    1280                 1285                 1290             


Pro Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Gly Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Val  Asp Ser Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Thr Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Thr Pro His Pro Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly Gln Glu Gly  Glu Ile Pro Phe Tyr  Gly Arg Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ser Tyr Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Leu Asn Ser Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Val  Val Asp Phe Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Ile Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Thr Gly Glu  Arg Ala Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ser Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Ser Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Val 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ser Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Val Met  Thr Ser Thr Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ala Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Val Cys  Ile Ile Gly Arg Leu  His Ile Asn Gln Arg  Ala Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Val Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Arg Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Ile 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Ser Lys  Gln Ala Gln Asp Ile  Gln Pro Thr Val Gln  Ala Ser Trp 
    1745                 1750                 1755             


Pro Lys  Val Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ser Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Leu Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Ile  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Ser Met  Glu Asp Val Val Asn  Leu Leu Pro Gly Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Pro Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Thr  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Leu Leu Gly 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Asn Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Ile Pro  Cys Gly Gly Ser Trp  Leu Arg Asp 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Thr  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Thr  Ser Lys Leu Phe Pro  Lys Met Pro Gly Leu  Pro Phe Val 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Ile 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly Asn Val 
    2030                 2035                 2040             


Arg Leu  Gly Ser Met Arg Ile  Thr Gly Pro Lys Thr  Cys Met Asn 
    2045                 2050                 2055             


Ile Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Gln 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Ala Pro  Asn Phe Lys Val Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Ala  Glu Val Thr Gln His  Gly Ser Tyr 
    2090                 2095                 2100             


His Tyr  Ile Thr Gly Leu Thr  Thr Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Leu  Pro Ser Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Thr  Pro Lys Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Ser  Phe Cys Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Asp Val Leu  Met Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Glu Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Arg Ala Thr Cys Thr  Thr His Gly 
    2210                 2215                 2220             


Lys Ala  Tyr Asp Val Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Gly Ser Lys Val  Val Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Pro Met Val  Glu Glu Arg Ser Asp  Leu Glu Pro 
    2255                 2260                 2265             


Ser Ile  Pro Ser Glu Tyr Met  Leu Pro Lys Lys Arg  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ala Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Ser  Trp Lys Arg Pro Asp  Tyr Gln Pro Ala Thr  Val Ala Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Pro Arg  Lys Thr Pro Thr Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Thr Val Gly Leu  Ser Glu Asp Ser Ile  Gly Asp Ala 
    2330                 2335                 2340             


Leu Gln  Gln Leu Ala Ile Lys  Ser Phe Gly Gln Pro  Pro Pro Ser 
    2345                 2350                 2355             


Gly Asp  Ser Gly Leu Ser Thr  Gly Ala Gly Ala Ala  Asp Ser Gly 
    2360                 2365                 2370             


Ser Gln  Thr Pro Pro Asp Glu  Leu Ala Leu Ser Glu  Thr Gly Ser 
    2375                 2380                 2385             


Ile Ser  Ser Met Pro Pro Leu  Glu Gly Glu Leu Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Pro Glu Gln Val Glu  Pro Gln Pro Pro Pro  Gln Gly Gly 
    2405                 2410                 2415             


Val Ala  Ala Pro Gly Ser Asp  Ser Gly Ser Trp Ser  Thr Cys Ser 
    2420                 2425                 2430             


Glu Glu  Asp Asp Ser Val Val  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Ser Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Leu Arg Tyr  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Cys Thr Thr Thr Lys  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Met Gln  Val Leu Asp Ser Tyr  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Lys Asp Ile Lys Leu  Ala Ala Ser Lys Val  Thr Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Met Glu Glu Ala  Cys Gln Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Arg  Ser Lys Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Gly  Arg Ala Val Asn His  Ile Lys Ser Val Trp  Lys Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Ser Glu Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Val Asp  Pro Thr Lys Gly Gly  Lys Lys Ala 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Thr Gln Lys Leu Pro  Gln Ala Val 
    2615                 2620                 2625             


Met Gly  Ala Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Gln Arg Val 
    2630                 2635                 2640             


Glu Phe  Leu Leu Lys Ala Trp  Ala Glu Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Arg Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Glu Glu  Ala His Thr Ala Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Phe Asn  Ser Lys Gly Gln Thr  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Ile  Thr Cys Tyr Val Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Ile Ala Pro Thr Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Thr Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Pro  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Gly Pro Gln Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Ala  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Ala Arg Met  Val Leu Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Met Ala Gln Asp Thr  Leu Asp Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Ser Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Asp Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Thr  Pro His Glu Leu Thr  Arg Val Ala 
    2915                 2920                 2925             


Ser Ala  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ser  Arg Gly Gly 
    2945                 2950                 2955             


Arg Ala  Ala Val Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Arg  Leu Leu Asp 
    2975                 2980                 2985             


Leu Ser  Ser Trp Phe Thr Val  Gly Ala Gly Gly Gly  Asp Ile Phe 
    2990                 2995                 3000             


His Ser  Val Ser Arg Ala Arg  Pro Arg Leu Leu Leu  Phe Gly Leu 
    3005                 3010                 3015             


Leu Leu  Leu Phe Val Gly Val  Gly Leu Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  89
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  89

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala 
            180                 185                 190         


Glu Val Lys Asn Ile Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Thr 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Val Gly Asn Ala Ser Gln Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Arg 
    370                 375                 380                 


Thr His Thr Val Gly Gly Ser Ala Ala Gln Thr Thr Gly Arg Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Asp Met Gly Pro Arg Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr His Ser Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ser Ala Cys Arg Ser Ile Glu Ala 
    450                 455                 460                 


Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Gln Cys 
                485                 490                 495     


Gly Val Val Ser Ala Lys Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Leu Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Ser 
545                 550                 555                 560 


Gly Tyr Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Phe Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Val Ile Leu His Ala Ala Ser Ala Ala Ser Cys Asn Gly 
        755                 760                 765             


Phe Leu Tyr Phe Val Ile Phe Phe Val Ala Ala Trp Tyr Ile Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Ala Thr Tyr Ser Leu Thr Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Ser Leu Leu Leu Leu Ala Leu Pro Gln Gln Ala Tyr Ala Tyr Asp Ala 
                805                 810                 815     


Ser Val His Gly Gln Ile Gly Ala Ala Leu Leu Val Met Ile Thr Leu 
            820                 825                 830         


Phe Thr Leu Thr Pro Gly Tyr Lys Thr Leu Leu Ser Arg Phe Leu Trp 
        835                 840                 845             


Trp Leu Cys Tyr Leu Leu Thr Leu Gly Glu Ala Met Val Gln Glu Trp 
    850                 855                 860                 


Ala Pro Pro Met Gln Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Ala 
865                 870                 875                 880 


Val Ala Ile Phe Tyr Pro Gly Val Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Val Leu Gly Pro Ala Tyr Leu Leu Lys Gly Ala Leu Thr Arg 
            900                 905                 910         


Val Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Met Cys Thr Met 
        915                 920                 925             


Ala Arg His Leu Ala Gly Gly Arg Tyr Val Gln Met Ala Leu Leu Ala 
    930                 935                 940                 


Leu Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Thr Pro Met 
945                 950                 955                 960 


Ser Asp Trp Ala Ala Ser Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Ile Ile Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Ala Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Ser Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Thr Ile Val Val Ser  Met Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Thr Glu Gln Ala  Gly Glu Ile Gln Val  Leu Ser Thr 
    1055                 1060                 1065             


Val Thr  Gln Ser Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Ser Arg 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Ser Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Glu  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Ala Arg Arg Arg Gly  Asp Lys Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Arg Gly His Ala  Val Gly Val Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ser  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Thr Leu  Asp Ile Val Thr Arg  Ser Pro Thr Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Val Ala Tyr 
    1235                 1240                 1245             


Ala Ala  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Leu Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Ala 
    1280                 1285                 1290             


Pro Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Gly Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Val  Asp Ser Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Thr Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Thr Pro His Pro Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly Gln Glu Gly  Glu Ile Pro Phe Tyr  Gly Arg Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ser Tyr Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Leu Asn Ser Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Val  Val Asp Phe Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Ile Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Thr Gly Glu  Arg Ala Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ser Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Ser Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Val 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ser Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Val Met  Thr Ser Thr Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ala Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Val Cys  Ile Ile Gly Arg Leu  His Ile Asn Gln Arg  Ala Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Val Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Arg Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Ile 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Ser Lys  Gln Ala Gln Asp Ile  Gln Pro Thr Val Gln  Ala Ser Trp 
    1745                 1750                 1755             


Pro Lys  Val Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ser Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Leu Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Ile  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Ser Met  Glu Asp Val Val Asn  Leu Leu Pro Gly Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Pro Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Thr  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Leu Leu Gly 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Asn Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Ile Pro  Cys Gly Gly Ser Trp  Leu Arg Asp 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Thr  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Thr  Ser Lys Leu Phe Pro  Lys Met Pro Gly Leu  Pro Phe Val 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Ile 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly Asn Val 
    2030                 2035                 2040             


Arg Leu  Gly Ser Met Arg Ile  Thr Gly Pro Lys Thr  Cys Met Asn 
    2045                 2050                 2055             


Ile Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Gln 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Ala Pro  Asn Phe Lys Val Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Ala  Glu Val Thr Gln His  Gly Ser Tyr 
    2090                 2095                 2100             


His Tyr  Ile Thr Gly Leu Thr  Thr Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Leu  Pro Ser Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Thr  Pro Lys Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Ser  Phe Cys Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Asp Val Leu  Met Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Glu Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Arg Ala Thr Cys Thr  Thr His Gly 
    2210                 2215                 2220             


Lys Ala  Tyr Asp Val Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Gly Ser Lys Val  Val Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Pro Met Val  Glu Glu Arg Ser Asp  Leu Glu Pro 
    2255                 2260                 2265             


Ser Ile  Pro Ser Glu Tyr Met  Leu Pro Lys Lys Arg  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ala Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Ser  Trp Lys Arg Pro Asp  Tyr Gln Pro Ala Thr  Val Ala Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Pro Arg  Lys Thr Pro Thr Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Thr Val Gly Leu  Ser Glu Asp Ser Ile  Gly Asp Ala 
    2330                 2335                 2340             


Leu Gln  Gln Leu Ala Ile Lys  Ser Phe Gly Gln Pro  Pro Pro Ser 
    2345                 2350                 2355             


Gly Asp  Ser Gly Leu Ser Thr  Gly Ala Gly Ala Ala  Asp Ser Gly 
    2360                 2365                 2370             


Ser Gln  Thr Pro Pro Asp Glu  Leu Ala Leu Ser Glu  Thr Gly Ser 
    2375                 2380                 2385             


Ile Ser  Ser Met Pro Pro Leu  Glu Gly Glu Leu Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Pro Glu Gln Val Glu  Pro Gln Pro Pro Pro  Gln Gly Gly 
    2405                 2410                 2415             


Val Ala  Ala Pro Gly Ser Asp  Ser Gly Ser Trp Ser  Thr Cys Ser 
    2420                 2425                 2430             


Glu Glu  Asp Asp Ser Val Val  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Ser Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Leu Arg Tyr  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Cys Thr Thr Thr Lys  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Met Gln  Val Leu Asp Ser Tyr  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Lys Asp Ile Lys Leu  Ala Ala Ser Lys Val  Thr Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Met Glu Glu Ala  Cys Gln Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Arg  Ser Lys Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Gly  Arg Ala Val Asn His  Ile Lys Ser Val Trp  Lys Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Ser Glu Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Val Asp  Pro Thr Lys Gly Gly  Lys Lys Ala 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Thr Gln Lys Leu Pro  Gln Ala Val 
    2615                 2620                 2625             


Met Gly  Ala Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Gln Arg Val 
    2630                 2635                 2640             


Glu Phe  Leu Leu Lys Ala Trp  Ala Glu Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Arg Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Glu Glu  Ala His Thr Ala Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Phe Asn  Ser Lys Gly Gln Thr  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Ile  Thr Cys Tyr Val Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Ile Ala Pro Thr Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Thr Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Pro  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Gly Pro Gln Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Ala  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Ala Arg Met  Val Leu Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Met Ala Gln Asp Thr  Leu Asp Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Ser Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Asp Ala 
    2900                 2905                 2910             


Phe Ser  Met His Thr Tyr Thr  His His Glu Leu Thr  Arg Val Ala 
    2915                 2920                 2925             


Ser Ala  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ser  Arg Gly Gly 
    2945                 2950                 2955             


Lys Ala  Ala Val Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Arg  Leu Leu Asp 
    2975                 2980                 2985             


Leu Ser  Ser Trp Phe Thr Val  Gly Ala Gly Gly Gly  Asp Ile Phe 
    2990                 2995                 3000             


His Ser  Val Ser Arg Ala Arg  Pro Arg Leu Leu Leu  Phe Gly Leu 
    3005                 3010                 3015             


Leu Leu  Leu Phe Val Gly Val  Gly Leu Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  90
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  90

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala 
            180                 185                 190         


Glu Val Lys Asn Ile Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Thr 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Val Gly Asn Ala Ser Gln Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Arg 
    370                 375                 380                 


Thr His Thr Val Gly Gly Ser Ala Ala Gln Thr Thr Gly Arg Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Asp Met Gly Pro Arg Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr His Ser Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ser Ala Cys Arg Ser Ile Glu Ala 
    450                 455                 460                 


Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Gln Cys 
                485                 490                 495     


Gly Val Val Ser Ala Lys Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Leu Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Ser 
545                 550                 555                 560 


Gly Tyr Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Phe Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Val Ile Leu His Ala Ala Ser Ala Ala Ser Cys Asn Gly 
        755                 760                 765             


Phe Leu Tyr Phe Val Ile Phe Phe Val Ala Ala Trp Tyr Ile Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Ala Thr Tyr Ser Leu Thr Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Ser Leu Leu Leu Leu Ala Leu Pro Gln Gln Ala Tyr Ala Tyr Asp Ala 
                805                 810                 815     


Ser Val His Gly Gln Ile Gly Ala Ala Leu Leu Val Met Ile Thr Leu 
            820                 825                 830         


Phe Thr Leu Thr Pro Gly Tyr Lys Thr Leu Leu Ser Arg Phe Leu Trp 
        835                 840                 845             


Trp Leu Cys Tyr Leu Leu Thr Leu Gly Glu Ala Met Val Gln Glu Trp 
    850                 855                 860                 


Ala Pro Pro Met Gln Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Ala 
865                 870                 875                 880 


Val Ala Ile Phe Tyr Pro Gly Val Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Val Leu Gly Pro Ala Tyr Leu Leu Lys Gly Ala Leu Thr Arg 
            900                 905                 910         


Val Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Met Cys Thr Met 
        915                 920                 925             


Ala Arg His Leu Ala Gly Gly Arg Tyr Val Gln Met Ala Leu Leu Ala 
    930                 935                 940                 


Leu Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Thr Pro Met 
945                 950                 955                 960 


Ser Asp Trp Ala Ala Ser Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Ile Ile Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Ala Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Ser Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Thr Ile Val Val Ser  Met Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Thr Glu Gln Ala  Gly Glu Ile Gln Val  Leu Ser Thr 
    1055                 1060                 1065             


Val Thr  Gln Ser Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Ser Arg 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Ser Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Glu  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Ala Arg Arg Arg Gly  Asp Lys Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Arg Gly His Ala  Val Gly Val Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ser  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Thr Leu  Asp Ile Val Thr Arg  Ser Pro Thr Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Val Ala Tyr 
    1235                 1240                 1245             


Ala Ala  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Leu Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Ala 
    1280                 1285                 1290             


Pro Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Gly Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Val  Asp Ser Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Thr Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Thr Pro His Pro Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly Gln Glu Gly  Glu Ile Pro Phe Tyr  Gly Arg Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ser Tyr Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Leu Asn Ser Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Val  Val Asp Phe Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Ile Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Thr Gly Glu  Arg Ala Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ser Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Ser Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Val 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ser Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Val Met  Thr Ser Thr Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ala Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Val Cys  Ile Ile Gly Arg Leu  His Ile Asn Gln Arg  Ala Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Val Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Arg Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Ile 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Ser Lys  Gln Ala Gln Asp Ile  Gln Pro Thr Val Gln  Ala Ser Trp 
    1745                 1750                 1755             


Pro Lys  Val Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ser Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Leu Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Ile  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Ser Met  Glu Asp Val Val Asn  Leu Leu Pro Gly Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Pro Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Thr  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Leu Leu Gly 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Asn Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Ile Pro  Cys Gly Gly Ser Trp  Leu Arg Asp 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Thr  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Thr  Ser Lys Leu Phe Pro  Lys Met Pro Gly Leu  Pro Phe Val 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Ile 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly Asn Val 
    2030                 2035                 2040             


Arg Leu  Gly Ser Met Arg Ile  Thr Gly Pro Lys Thr  Cys Met Asn 
    2045                 2050                 2055             


Ile Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Gln 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Ala Pro  Asn Phe Lys Val Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Ala  Glu Val Thr Gln His  Gly Ser Tyr 
    2090                 2095                 2100             


His Tyr  Ile Thr Gly Leu Thr  Thr Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Leu  Pro Ser Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Thr  Pro Lys Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Ser  Phe Cys Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Asp Val Leu  Met Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Glu Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Arg Ala Thr Cys Thr  Thr His Gly 
    2210                 2215                 2220             


Lys Ala  Tyr Asp Val Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Gly Ser Lys Val  Val Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Pro Met Val  Glu Glu Arg Ser Asp  Leu Glu Pro 
    2255                 2260                 2265             


Ser Ile  Pro Ser Glu Tyr Met  Leu Pro Lys Lys Arg  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ala Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Ser  Trp Lys Arg Pro Asp  Tyr Gln Pro Ala Thr  Val Ala Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Pro Arg  Lys Thr Pro Thr Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Thr Val Gly Leu  Ser Glu Asp Ser Ile  Gly Asp Ala 
    2330                 2335                 2340             


Leu Gln  Gln Leu Ala Ile Lys  Ser Phe Gly Gln Pro  Pro Pro Ser 
    2345                 2350                 2355             


Gly Asp  Ser Gly Leu Ser Thr  Gly Ala Gly Ala Ala  Asp Ser Gly 
    2360                 2365                 2370             


Ser Gln  Thr Pro Pro Asp Glu  Leu Ala Leu Ser Glu  Thr Gly Ser 
    2375                 2380                 2385             


Ile Ser  Ser Met Pro Pro Leu  Glu Gly Glu Leu Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Pro Glu Gln Val Glu  Pro Gln Pro Pro Pro  Gln Gly Gly 
    2405                 2410                 2415             


Val Ala  Ala Pro Gly Ser Asp  Ser Gly Ser Trp Ser  Thr Cys Ser 
    2420                 2425                 2430             


Glu Glu  Asp Asp Ser Val Val  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Ser Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Leu Arg Tyr  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Cys Thr Thr Thr Lys  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Met Gln  Val Leu Asp Ser Tyr  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Lys Asp Ile Lys Leu  Ala Ala Ser Lys Val  Thr Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Met Glu Glu Ala  Cys Gln Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Arg  Ser Lys Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Gly  Arg Ala Val Asn His  Ile Lys Ser Val Trp  Lys Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Ser Glu Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Val Asp  Pro Thr Lys Gly Gly  Lys Lys Ala 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Thr Gln Lys Leu Pro  Gln Ala Val 
    2615                 2620                 2625             


Met Gly  Ala Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Gln Arg Val 
    2630                 2635                 2640             


Glu Phe  Leu Leu Lys Ala Trp  Ala Glu Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Arg Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Glu Glu  Ala His Thr Ala Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Phe Asn  Ser Lys Gly Gln Thr  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Ile  Thr Cys Tyr Val Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Ile Ala Pro Thr Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Thr Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Pro  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Gly Pro Gln Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Ala  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Ala Arg Met  Val Leu Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Met Ala Gln Asp Thr  Leu Asp Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Ser Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Asp Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Thr  Pro His Glu Leu Thr  Arg Val Ala 
    2915                 2920                 2925             


Ser Ala  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ser  Arg Gly Gly 
    2945                 2950                 2955             


Arg Ala  Ala Val Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Arg  Leu Leu Asp 
    2975                 2980                 2985             


Leu Ser  Ser Trp Phe Thr Val  Gly Ala Gly Gly Gly  Asp Ile Tyr 
    2990                 2995                 3000             


His Ser  Val Ser Arg Ala Arg  Pro Arg Leu Leu Leu  Phe Gly Leu 
    3005                 3010                 3015             


Leu Leu  Leu Phe Val Gly Val  Gly Leu Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  91
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  91

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala 
            180                 185                 190         


Glu Val Lys Asn Ile Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Thr 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Val Gly Asn Ala Ser Gln Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Arg 
    370                 375                 380                 


Thr His Thr Val Gly Gly Ser Ala Ala Gln Thr Thr Gly Arg Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Asp Met Gly Pro Arg Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr His Ser Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ser Ala Cys Arg Ser Ile Glu Ala 
    450                 455                 460                 


Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Gln Cys 
                485                 490                 495     


Gly Val Val Ser Ala Lys Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Leu Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Ser 
545                 550                 555                 560 


Gly Tyr Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Phe Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Val Ile Leu His Ala Ala Ser Ala Ala Ser Cys Asn Gly 
        755                 760                 765             


Phe Leu Tyr Phe Val Ile Phe Phe Val Ala Ala Trp Tyr Ile Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Ala Thr Tyr Ser Leu Thr Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Ser Leu Leu Leu Leu Ala Leu Pro Gln Gln Ala Tyr Ala Tyr Asp Ala 
                805                 810                 815     


Ser Val His Gly Gln Ile Gly Ala Ala Leu Leu Val Met Ile Thr Leu 
            820                 825                 830         


Phe Thr Leu Thr Pro Gly Tyr Lys Thr Leu Leu Ser Arg Phe Leu Trp 
        835                 840                 845             


Trp Leu Cys Tyr Leu Leu Thr Leu Gly Glu Ala Met Val Gln Glu Trp 
    850                 855                 860                 


Ala Pro Pro Met Gln Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Ala 
865                 870                 875                 880 


Val Ala Ile Phe Tyr Pro Gly Val Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Val Leu Gly Pro Ala Tyr Leu Leu Lys Gly Ala Leu Thr Arg 
            900                 905                 910         


Val Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Met Cys Thr Met 
        915                 920                 925             


Ala Arg His Leu Ala Gly Gly Arg Tyr Val Gln Met Ala Leu Leu Ala 
    930                 935                 940                 


Leu Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Thr Pro Met 
945                 950                 955                 960 


Ser Asp Trp Ala Ala Ser Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Ile Ile Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Ala Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Ser Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Thr Ile Val Val Ser  Met Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Thr Glu Gln Ala  Gly Glu Ile Gln Val  Leu Ser Thr 
    1055                 1060                 1065             


Val Thr  Gln Ser Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Ser Arg 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Ser Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Glu  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Ala Arg Arg Arg Gly  Asp Lys Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Arg Gly His Ala  Val Gly Val Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ser  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Thr Leu  Asp Ile Val Thr Arg  Ser Pro Thr Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Val Ala Tyr 
    1235                 1240                 1245             


Ala Ala  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Leu Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Ala 
    1280                 1285                 1290             


Pro Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Gly Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Val  Asp Ser Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Thr Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Thr Pro His Pro Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly Gln Glu Gly  Glu Ile Pro Phe Tyr  Gly Arg Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ser Tyr Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Leu Asn Ser Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Val  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Ile Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Thr Gly Glu  Arg Ala Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ser Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Ser Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Val 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ser Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Val Met  Thr Ser Thr Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Val Cys  Ile Ile Gly Arg Leu  His Ile Asn Gln Arg  Ala Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Val Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Arg Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Ile 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Ser Lys  Gln Ala Gln Asp Ile  Gln Pro Thr Val Gln  Ala Ser Trp 
    1745                 1750                 1755             


Pro Lys  Val Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ser Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Leu Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Ile  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Ser Met  Glu Asp Val Val Asn  Leu Leu Pro Gly Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Pro Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Thr  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Leu Leu Gly 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Asn Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Ile Pro  Cys Gly Gly Ser Trp  Leu Arg Asp 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Thr  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Thr  Ser Lys Leu Phe Pro  Lys Met Pro Gly Leu  Pro Phe Val 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Ile 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly Asn Val 
    2030                 2035                 2040             


Arg Leu  Gly Ser Met Arg Ile  Thr Gly Pro Lys Thr  Cys Met Asn 
    2045                 2050                 2055             


Ile Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Gln 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Ala Pro  Asn Phe Lys Val Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Ala  Glu Val Thr Gln His  Gly Ser Tyr 
    2090                 2095                 2100             


His Tyr  Ile Thr Gly Leu Thr  Thr Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Leu  Pro Ser Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Thr  Pro Lys Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Ser  Phe Cys Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Asp Val Leu  Met Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Glu Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Arg Ala Thr Cys Thr  Thr His Gly 
    2210                 2215                 2220             


Lys Ala  Tyr Asp Val Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Gly Ser Lys Val  Val Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Pro Met Val  Glu Glu Arg Ser Asp  Leu Glu Pro 
    2255                 2260                 2265             


Ser Ile  Pro Ser Glu Tyr Met  Leu Pro Lys Lys Arg  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ala Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Ser  Trp Lys Arg Pro Asp  Tyr Gln Pro Ala Thr  Val Ala Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Pro Arg  Lys Thr Pro Thr Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Thr Val Gly Leu  Ser Glu Asp Ser Ile  Gly Asp Ala 
    2330                 2335                 2340             


Leu Gln  Gln Leu Ala Ile Lys  Ser Phe Gly Gln Pro  Pro Pro Ser 
    2345                 2350                 2355             


Gly Asp  Ser Gly Leu Ser Thr  Gly Ala Gly Ala Ala  Asp Ser Gly 
    2360                 2365                 2370             


Ser Gln  Thr Pro Pro Asp Glu  Leu Ala Leu Ser Glu  Thr Gly Ser 
    2375                 2380                 2385             


Ile Ser  Ser Met Pro Pro Leu  Glu Gly Glu Leu Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Pro Glu Gln Val Glu  Pro Gln Pro Pro Pro  Gln Gly Gly 
    2405                 2410                 2415             


Val Ala  Ala Pro Gly Ser Asp  Ser Gly Ser Trp Ser  Thr Cys Ser 
    2420                 2425                 2430             


Glu Glu  Asp Asp Ser Val Val  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Ser Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Leu Arg Tyr  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Cys Thr Thr Thr Lys  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Met Gln  Val Leu Asp Ser Tyr  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Lys Asp Ile Lys Leu  Ala Ala Ser Lys Val  Thr Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Met Glu Glu Ala  Cys Gln Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Arg  Ser Lys Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Gly  Arg Ala Val Asn His  Ile Lys Ser Val Trp  Lys Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Ser Glu Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Val Asp  Pro Thr Lys Gly Gly  Lys Lys Ala 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Thr Gln Lys Leu Pro  Gln Ala Val 
    2615                 2620                 2625             


Met Gly  Ala Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Gln Arg Val 
    2630                 2635                 2640             


Glu Phe  Leu Leu Lys Ala Trp  Ala Glu Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Arg Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Glu Glu  Ala His Thr Ala Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Phe Asn  Ser Lys Gly Gln Thr  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Ile  Thr Cys Tyr Val Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Ile Ala Pro Thr Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Thr Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Pro  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Gly Pro Gln Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Ala  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Ala Arg Met  Val Leu Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Met Ala Gln Asp Thr  Leu Asp Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Ser Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Asp Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Thr  Pro His Glu Leu Thr  Arg Val Ala 
    2915                 2920                 2925             


Ser Ala  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ser  Arg Gly Gly 
    2945                 2950                 2955             


Arg Ala  Ala Val Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Arg  Leu Leu Asp 
    2975                 2980                 2985             


Leu Ser  Ser Trp Phe Thr Val  Gly Ala Gly Gly Gly  Gly Ile Tyr 
    2990                 2995                 3000             


His Ser  Val Ser Arg Ala Arg  Pro Arg Leu Leu Leu  Phe Gly Leu 
    3005                 3010                 3015             


Leu Leu  Leu Phe Val Gly Val  Gly Leu Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  92
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  92

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala 
            180                 185                 190         


Glu Val Lys Asn Ile Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Thr 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Val Gly Asn Ala Ser Gln Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Arg 
    370                 375                 380                 


Thr His Thr Val Gly Gly Ser Ala Ala Gln Thr Thr Gly Arg Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Asp Met Gly Pro Arg Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr His Ser Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ser Ala Cys Arg Ser Ile Glu Ala 
    450                 455                 460                 


Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Gln Cys 
                485                 490                 495     


Gly Val Val Ser Ala Lys Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Leu Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Ser 
545                 550                 555                 560 


Gly Tyr Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Phe Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Val Ile Leu His Ala Ala Ser Ala Ala Ser Cys Asn Gly 
        755                 760                 765             


Phe Leu Tyr Phe Val Ile Phe Phe Val Ala Ala Trp Tyr Ile Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Ala Thr Tyr Ser Leu Thr Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Ser Leu Leu Leu Leu Ala Leu Pro Gln Gln Ala Tyr Ala Tyr Asp Ala 
                805                 810                 815     


Ser Val His Gly Gln Ile Gly Ala Ala Leu Leu Val Met Ile Thr Leu 
            820                 825                 830         


Phe Thr Leu Thr Pro Gly Tyr Lys Thr Leu Leu Ser Arg Phe Leu Trp 
        835                 840                 845             


Trp Leu Cys Tyr Leu Leu Thr Leu Gly Glu Ala Met Val Gln Glu Trp 
    850                 855                 860                 


Ala Pro Pro Met Gln Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Ala 
865                 870                 875                 880 


Val Ala Ile Phe Tyr Pro Gly Val Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Val Leu Gly Pro Ala Tyr Leu Leu Lys Gly Ala Leu Thr Arg 
            900                 905                 910         


Val Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Met Cys Thr Met 
        915                 920                 925             


Ala Arg His Leu Ala Gly Gly Arg Tyr Val Gln Met Ala Leu Leu Ala 
    930                 935                 940                 


Leu Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Thr Pro Met 
945                 950                 955                 960 


Ser Asp Trp Ala Ala Ser Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Ile Ile Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Ala Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Ser Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Thr Ile Val Val Ser  Met Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Thr Glu Gln Ala  Gly Glu Ile Gln Val  Leu Ser Thr 
    1055                 1060                 1065             


Val Thr  Gln Ser Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Ser Arg 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Ser Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Glu  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Ala Arg Arg Arg Gly  Asp Lys Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Arg Gly His Ala  Val Gly Val Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ser  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Thr Leu  Asp Ile Val Thr Arg  Ser Pro Thr Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Val Ala Tyr 
    1235                 1240                 1245             


Ala Ala  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Leu Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Ala 
    1280                 1285                 1290             


Pro Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Gly Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Val  Asp Ser Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Thr Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Thr Pro His Pro Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly Gln Glu Gly  Glu Ile Pro Phe Tyr  Gly Arg Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ser Tyr Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Leu Asn Ser Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Val  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Ile Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Thr Gly Glu  Arg Ala Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ser Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Ser Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Val 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ser Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Val Met  Thr Ser Thr Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Val Cys  Ile Ile Gly Arg Leu  His Ile Asn Gln Arg  Ala Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Val Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Arg Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Ile 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Ser Lys  Gln Ala Gln Asp Ile  Gln Pro Thr Val Gln  Ala Ser Trp 
    1745                 1750                 1755             


Pro Lys  Val Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ser Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Leu Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Ile  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Ser Met  Glu Asp Val Val Asn  Leu Leu Pro Gly Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Pro Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Thr  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Leu Leu Gly 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Asn Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Ile Pro  Cys Gly Gly Ser Trp  Leu Arg Asp 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Thr  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Thr  Ser Lys Leu Phe Pro  Lys Met Pro Gly Leu  Pro Phe Val 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Ile 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly Asn Val 
    2030                 2035                 2040             


Arg Leu  Gly Ser Met Arg Ile  Thr Gly Pro Lys Thr  Cys Met Asn 
    2045                 2050                 2055             


Ile Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Gln 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Ala Pro  Asn Phe Lys Val Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Ala  Glu Val Thr Gln His  Gly Ser Tyr 
    2090                 2095                 2100             


His Tyr  Ile Thr Gly Leu Thr  Thr Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Leu  Pro Ser Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Thr  Pro Lys Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Ser  Phe Cys Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Asp Val Leu  Met Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Glu Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Arg Ala Thr Cys Thr  Thr His Gly 
    2210                 2215                 2220             


Lys Ala  Tyr Asp Val Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Gly Ser Lys Val  Val Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Pro Met Val  Glu Glu Arg Ser Asp  Leu Glu Pro 
    2255                 2260                 2265             


Ser Ile  Pro Ser Glu Tyr Met  Leu Pro Lys Lys Arg  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ala Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Ser  Trp Lys Arg Pro Asp  Tyr Gln Pro Ala Thr  Val Ala Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Pro Arg  Lys Thr Pro Thr Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Thr Val Gly Leu  Ser Glu Asp Ser Ile  Gly Asp Ala 
    2330                 2335                 2340             


Leu Gln  Gln Leu Ala Ile Lys  Ser Phe Gly Gln Pro  Pro Pro Ser 
    2345                 2350                 2355             


Gly Asp  Ser Gly Leu Ser Thr  Gly Ala Gly Ala Ala  Asp Ser Gly 
    2360                 2365                 2370             


Ser Gln  Thr Pro Pro Asp Glu  Leu Ala Leu Ser Glu  Thr Gly Ser 
    2375                 2380                 2385             


Ile Ser  Ser Met Pro Pro Leu  Glu Gly Glu Leu Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Pro Glu Gln Val Glu  Pro Gln Pro Pro Pro  Gln Gly Gly 
    2405                 2410                 2415             


Val Ala  Ala Pro Gly Ser Asp  Ser Gly Ser Trp Ser  Thr Cys Ser 
    2420                 2425                 2430             


Glu Glu  Asp Asp Ser Val Val  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Ser Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Leu Arg Tyr  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Cys Thr Thr Thr Lys  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Met Gln  Val Leu Asp Ser Tyr  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Lys Asp Ile Lys Leu  Ala Ala Ser Lys Val  Thr Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Met Glu Glu Ala  Cys Gln Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Arg  Ser Lys Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Gly  Arg Ala Val Asn His  Ile Lys Ser Val Trp  Lys Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Ser Glu Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Val Asp  Pro Thr Lys Gly Gly  Lys Lys Ala 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Thr Gln Lys Leu Pro  Gln Ala Val 
    2615                 2620                 2625             


Met Gly  Ala Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Gln Arg Val 
    2630                 2635                 2640             


Glu Phe  Leu Leu Lys Ala Trp  Ala Glu Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Arg Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Glu Glu  Ala His Thr Ala Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Phe Asn  Ser Lys Gly Gln Thr  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Ile  Thr Cys Tyr Val Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Ile Ala Pro Thr Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Thr Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Pro  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Gly Pro Gln Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Ala  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Ala Arg Met  Val Leu Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Met Ala Gln Asp Thr  Leu Asp Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Ser Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Asp Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Thr  Pro His Glu Leu Thr  Arg Val Ala 
    2915                 2920                 2925             


Ser Ala  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ser  Arg Gly Gly 
    2945                 2950                 2955             


Arg Ala  Ala Val Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Arg  Leu Leu Asp 
    2975                 2980                 2985             


Leu Ser  Ser Trp Phe Thr Val  Gly Ala Gly Gly Gly  Gly Ile Phe 
    2990                 2995                 3000             


His Ser  Val Ser Arg Ala Arg  Pro Arg Leu Leu Leu  Phe Gly Leu 
    3005                 3010                 3015             


Leu Leu  Leu Phe Val Gly Val  Gly Leu Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  93
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  93

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala 
            180                 185                 190         


Glu Val Lys Asn Ile Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Thr 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Val Gly Asn Ala Ser Gln Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Arg 
    370                 375                 380                 


Thr His Thr Val Gly Gly Ser Ala Ala Gln Thr Thr Gly Arg Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Asp Met Gly Pro Arg Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr His Ser Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ser Ala Cys Arg Ser Ile Glu Ala 
    450                 455                 460                 


Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Gln Cys 
                485                 490                 495     


Gly Val Val Ser Ala Lys Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Leu Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Ser 
545                 550                 555                 560 


Gly Tyr Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Phe Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Val Ile Leu His Ala Ala Ser Ala Ala Ser Cys Asn Gly 
        755                 760                 765             


Phe Leu Tyr Phe Val Ile Phe Phe Val Ala Ala Trp Tyr Ile Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Ala Thr Tyr Ser Leu Thr Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Ser Leu Leu Leu Leu Ala Leu Pro Gln Gln Ala Tyr Ala Tyr Asp Ala 
                805                 810                 815     


Ser Val His Gly Gln Ile Gly Ala Ala Leu Leu Val Met Ile Thr Leu 
            820                 825                 830         


Phe Thr Leu Thr Pro Gly Tyr Lys Thr Leu Leu Ser Arg Phe Leu Trp 
        835                 840                 845             


Trp Leu Cys Tyr Leu Leu Thr Leu Gly Glu Ala Met Val Gln Glu Trp 
    850                 855                 860                 


Ala Pro Pro Met Gln Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Ala 
865                 870                 875                 880 


Val Ala Ile Phe Tyr Pro Gly Val Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Val Leu Gly Pro Ala Tyr Leu Leu Lys Gly Ala Leu Thr Arg 
            900                 905                 910         


Val Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Met Cys Thr Met 
        915                 920                 925             


Ala Arg His Leu Ala Gly Gly Arg Tyr Val Gln Met Ala Leu Leu Ala 
    930                 935                 940                 


Leu Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Thr Pro Met 
945                 950                 955                 960 


Ser Asp Trp Ala Ala Ser Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Ile Ile Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Ala Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Ser Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Thr Ile Val Val Ser  Met Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Thr Glu Gln Ala  Gly Glu Ile Gln Val  Leu Ser Thr 
    1055                 1060                 1065             


Val Thr  Gln Ser Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Ser Arg 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Ser Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Glu  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Ala Arg Arg Arg Gly  Asp Lys Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Arg Gly His Ala  Val Gly Val Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ser  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Thr Leu  Asp Ile Val Thr Arg  Ser Pro Thr Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Val Ala Tyr 
    1235                 1240                 1245             


Ala Ala  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Leu Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Ala 
    1280                 1285                 1290             


Pro Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Gly Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Val  Asp Ser Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Thr Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Thr Pro His Pro Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly Gln Glu Gly  Glu Ile Pro Phe Tyr  Gly Arg Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ser Tyr Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Leu Asn Ser Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Val  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Ile Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Thr Gly Glu  Arg Ala Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ser Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Ser Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Val 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ser Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Val Met  Thr Ser Thr Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Val Cys  Ile Ile Gly Arg Leu  His Ile Asn Gln Arg  Ala Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Val Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Arg Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Ile 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Ser Lys  Gln Ala Gln Asp Ile  Gln Pro Thr Val Gln  Ala Ser Trp 
    1745                 1750                 1755             


Pro Lys  Val Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ser Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Leu Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Ile  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Ser Met  Glu Asp Val Val Asn  Leu Leu Pro Gly Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Pro Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Thr  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Leu Leu Gly 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Asn Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Ile Pro  Cys Gly Gly Ser Trp  Leu Arg Asp 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Thr  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Thr  Ser Lys Leu Phe Pro  Lys Met Pro Gly Leu  Pro Phe Val 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Ile 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly Asn Val 
    2030                 2035                 2040             


Arg Leu  Gly Ser Met Arg Ile  Thr Gly Pro Lys Thr  Cys Met Asn 
    2045                 2050                 2055             


Ile Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Gln 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Ala Pro  Asn Phe Lys Val Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Ala  Glu Val Thr Gln His  Gly Ser Tyr 
    2090                 2095                 2100             


His Tyr  Ile Thr Gly Leu Thr  Thr Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Leu  Pro Ser Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Thr  Pro Lys Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Ser  Phe Cys Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Asp Val Leu  Met Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Glu Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Arg Ala Thr Cys Thr  Thr His Gly 
    2210                 2215                 2220             


Lys Ala  Tyr Asp Val Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Gly Ser Lys Val  Val Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Pro Met Val  Glu Glu Arg Ser Asp  Leu Glu Pro 
    2255                 2260                 2265             


Ser Ile  Pro Ser Glu Tyr Met  Leu Pro Lys Lys Arg  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ala Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Ser  Trp Lys Arg Pro Asp  Tyr Gln Pro Ala Thr  Val Ala Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Pro Arg  Lys Thr Pro Thr Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Thr Val Gly Leu  Ser Glu Asp Ser Ile  Gly Asp Ala 
    2330                 2335                 2340             


Leu Gln  Gln Leu Ala Ile Lys  Ser Phe Gly Gln Pro  Pro Pro Ser 
    2345                 2350                 2355             


Gly Asp  Ser Gly Leu Ser Thr  Gly Ala Gly Ala Ala  Asp Ser Gly 
    2360                 2365                 2370             


Ser Gln  Thr Pro Pro Asp Glu  Leu Ala Leu Ser Glu  Thr Gly Ser 
    2375                 2380                 2385             


Ile Ser  Ser Met Pro Pro Leu  Glu Gly Glu Leu Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Pro Glu Gln Val Glu  Pro Gln Pro Pro Pro  Gln Gly Gly 
    2405                 2410                 2415             


Val Ala  Ala Pro Gly Ser Asp  Ser Gly Ser Trp Ser  Thr Cys Ser 
    2420                 2425                 2430             


Glu Glu  Asp Asp Ser Val Val  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Ser Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Leu Arg Tyr  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Cys Thr Thr Thr Lys  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Met Gln  Val Leu Asp Ser Tyr  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Lys Asp Ile Lys Leu  Ala Ala Ser Lys Val  Thr Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Met Glu Glu Ala  Cys Gln Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Arg  Ser Lys Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Gly  Arg Ala Val Asn His  Ile Lys Ser Val Trp  Lys Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Ser Glu Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Val Asp  Pro Thr Lys Gly Gly  Lys Lys Ala 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Thr Gln Lys Leu Pro  Gln Ala Val 
    2615                 2620                 2625             


Met Gly  Ala Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Gln Arg Val 
    2630                 2635                 2640             


Glu Phe  Leu Leu Lys Ala Trp  Ala Glu Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Arg Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Glu Glu  Ala His Thr Ala Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Phe Asn  Ser Lys Gly Gln Thr  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Ile  Thr Cys Tyr Val Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Ile Ala Pro Thr Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Thr Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Pro  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Gly Pro Gln Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Ala  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Ala Arg Met  Val Leu Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Met Ala Gln Asp Thr  Leu Asp Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Ser Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Asp Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Thr  Pro His Glu Leu Thr  Arg Val Ala 
    2915                 2920                 2925             


Ser Ala  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ser  Arg Gly Gly 
    2945                 2950                 2955             


Arg Ala  Ala Val Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Arg  Leu Leu Asp 
    2975                 2980                 2985             


Leu Ser  Ser Trp Phe Thr Val  Gly Ala Gly Gly Gly  Gly Ile Tyr 
    2990                 2995                 3000             


His Ser  Val Ser Arg Ala Arg  Pro Arg Leu Leu Leu  Phe Gly Leu 
    3005                 3010                 3015             


Leu Leu  Leu Phe Val Gly Val  Gly Leu Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  94
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  94

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala 
            180                 185                 190         


Glu Val Lys Asn Ile Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Thr 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Val Gly Asn Ala Ser Gln Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Arg 
    370                 375                 380                 


Thr His Thr Val Gly Gly Ser Ala Ala Gln Thr Thr Gly Arg Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Asp Met Gly Pro Arg Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr His Ser Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ser Ala Cys Arg Ser Ile Glu Ala 
    450                 455                 460                 


Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Gln Cys 
                485                 490                 495     


Gly Val Val Ser Ala Lys Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Leu Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Ser 
545                 550                 555                 560 


Gly Tyr Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Phe Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Val Ile Leu His Ala Ala Ser Ala Ala Ser Cys Asn Gly 
        755                 760                 765             


Phe Leu Tyr Phe Val Ile Phe Phe Val Ala Ala Trp Tyr Ile Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Ala Thr Tyr Ser Leu Thr Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Ser Leu Leu Leu Leu Ala Leu Pro Gln Gln Ala Tyr Ala Tyr Asp Ala 
                805                 810                 815     


Ser Val His Gly Gln Ile Gly Ala Ala Leu Leu Val Met Ile Thr Leu 
            820                 825                 830         


Phe Thr Leu Thr Pro Gly Tyr Lys Thr Leu Leu Ser Arg Phe Leu Trp 
        835                 840                 845             


Trp Leu Cys Tyr Leu Leu Thr Leu Gly Glu Ala Met Val Gln Glu Trp 
    850                 855                 860                 


Ala Pro Pro Met Gln Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Ala 
865                 870                 875                 880 


Val Ala Ile Phe Tyr Pro Gly Val Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Val Leu Gly Pro Ala Tyr Leu Leu Lys Gly Ala Leu Thr Arg 
            900                 905                 910         


Val Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Met Cys Thr Met 
        915                 920                 925             


Ala Arg His Leu Ala Gly Gly Arg Tyr Val Gln Met Ala Leu Leu Ala 
    930                 935                 940                 


Leu Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Thr Pro Met 
945                 950                 955                 960 


Ser Asp Trp Ala Ala Ser Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Ile Ile Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Ala Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Ser Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Thr Ile Val Val Ser  Met Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Thr Glu Gln Ala  Gly Glu Ile Gln Val  Leu Ser Thr 
    1055                 1060                 1065             


Val Thr  Gln Ser Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Ser Arg 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Ser Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Glu  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Ala Arg Arg Arg Gly  Asp Lys Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Arg Gly His Ala  Val Gly Val Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ser  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Thr Leu  Asp Ile Val Thr Arg  Ser Pro Thr Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Val Ala Tyr 
    1235                 1240                 1245             


Ala Ala  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Leu Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Ala 
    1280                 1285                 1290             


Pro Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Gly Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Val  Asp Ser Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Thr Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Thr Pro His Pro Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly Gln Glu Gly  Glu Ile Pro Phe Tyr  Gly Arg Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ser Tyr Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Leu Asn Ser Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Val  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Ile Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Thr Gly Glu  Arg Ala Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ser Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Ser Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Val 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ser Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Val Met  Thr Ser Thr Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Val Cys  Ile Ile Gly Arg Leu  His Ile Asn Gln Arg  Ala Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Val Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Arg Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Ile 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Ser Lys  Gln Ala Gln Asp Ile  Gln Pro Thr Val Gln  Ala Ser Trp 
    1745                 1750                 1755             


Pro Lys  Val Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ser Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Leu Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Ile  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Ser Met  Glu Asp Val Val Asn  Leu Leu Pro Gly Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Pro Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Thr  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Leu Leu Gly 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Asn Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Ile Pro  Cys Gly Gly Ser Trp  Leu Arg Asp 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Thr  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Thr  Ser Lys Leu Phe Pro  Lys Met Pro Gly Leu  Pro Phe Val 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Ile 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly Asn Val 
    2030                 2035                 2040             


Arg Leu  Gly Ser Met Arg Ile  Thr Gly Pro Lys Thr  Cys Met Asn 
    2045                 2050                 2055             


Ile Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Gln 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Ala Pro  Asn Phe Lys Val Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Ala  Glu Val Thr Gln His  Gly Ser Tyr 
    2090                 2095                 2100             


His Tyr  Ile Thr Gly Leu Thr  Thr Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Leu  Pro Ser Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Thr  Pro Lys Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Ser  Phe Cys Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Asp Val Leu  Met Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Glu Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Arg Ala Thr Cys Thr  Thr His Gly 
    2210                 2215                 2220             


Lys Ala  Tyr Asp Val Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Gly Ser Lys Val  Val Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Pro Met Val  Glu Glu Arg Ser Asp  Leu Glu Pro 
    2255                 2260                 2265             


Ser Ile  Pro Ser Glu Tyr Met  Leu Pro Lys Lys Arg  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ala Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Ser  Trp Lys Arg Pro Asp  Tyr Gln Pro Ala Thr  Val Ala Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Pro Arg  Lys Thr Pro Thr Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Thr Val Gly Leu  Ser Glu Asp Ser Ile  Gly Asp Ala 
    2330                 2335                 2340             


Leu Gln  Gln Leu Ala Ile Lys  Ser Phe Gly Gln Pro  Pro Pro Ser 
    2345                 2350                 2355             


Gly Asp  Ser Gly Leu Ser Thr  Gly Ala Gly Ala Ala  Asp Ser Gly 
    2360                 2365                 2370             


Ser Gln  Thr Pro Pro Asp Glu  Leu Ala Leu Ser Glu  Thr Gly Ser 
    2375                 2380                 2385             


Ile Ser  Ser Met Pro Pro Leu  Glu Gly Glu Leu Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Pro Glu Gln Val Glu  Pro Gln Pro Pro Pro  Gln Gly Gly 
    2405                 2410                 2415             


Val Ala  Ala Pro Gly Ser Asp  Ser Gly Ser Trp Ser  Thr Cys Ser 
    2420                 2425                 2430             


Glu Glu  Asp Asp Ser Val Val  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Ser Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Leu Arg Tyr  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Cys Thr Thr Thr Lys  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Met Gln  Val Leu Asp Ser Tyr  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Lys Asp Ile Lys Leu  Ala Ala Ser Lys Val  Thr Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Met Glu Glu Ala  Cys Gln Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Arg  Ser Lys Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Gly  Arg Ala Val Asn His  Ile Lys Ser Val Trp  Lys Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Ser Glu Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Val Asp  Pro Thr Lys Gly Gly  Lys Lys Ala 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Thr Gln Lys Leu Pro  Gln Ala Val 
    2615                 2620                 2625             


Met Gly  Ala Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Gln Arg Val 
    2630                 2635                 2640             


Glu Phe  Leu Leu Lys Ala Trp  Ala Glu Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Arg Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Glu Glu  Ala His Thr Ala Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Phe Asn  Ser Lys Gly Gln Thr  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Ile  Thr Cys Tyr Val Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Ile Ala Pro Thr Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Thr Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Pro  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Gly Pro Gln Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Ala  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Ala Arg Met  Val Leu Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Met Ala Gln Asp Thr  Leu Asp Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Ser Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Asp Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Thr  Pro His Glu Leu Thr  Arg Val Ala 
    2915                 2920                 2925             


Ser Ala  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ser  Arg Gly Gly 
    2945                 2950                 2955             


Arg Ala  Ala Val Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Arg  Leu Leu Asp 
    2975                 2980                 2985             


Leu Ser  Ser Trp Phe Thr Val  Gly Ala Gly Gly Gly  Gly Ile Phe 
    2990                 2995                 3000             


His Ser  Val Ser Arg Ala Arg  Pro Arg Leu Leu Leu  Phe Gly Leu 
    3005                 3010                 3015             


Leu Leu  Leu Phe Val Gly Val  Gly Leu Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  95
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  95

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala 
            180                 185                 190         


Glu Val Lys Asn Ile Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Thr 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Val Gly Asn Ala Ser Gln Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Arg 
    370                 375                 380                 


Thr His Thr Val Gly Gly Ser Ala Ala Gln Thr Thr Gly Arg Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Asp Met Gly Pro Arg Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr His Ser Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ser Ala Cys Arg Ser Ile Glu Ala 
    450                 455                 460                 


Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Gln Cys 
                485                 490                 495     


Gly Val Val Ser Ala Lys Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Leu Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Ser 
545                 550                 555                 560 


Gly Tyr Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Phe Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Val Ile Leu His Ala Ala Ser Ala Ala Ser Cys Asn Gly 
        755                 760                 765             


Phe Leu Tyr Phe Val Ile Phe Ser Val Ala Ala Trp Tyr Ile Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Ala Thr Tyr Ser Leu Thr Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Ser Leu Leu Leu Leu Ala Leu Pro Gln Gln Ala Tyr Ala Tyr Asp Ala 
                805                 810                 815     


Ser Val His Gly Gln Ile Gly Ala Ala Leu Leu Val Met Ile Thr Leu 
            820                 825                 830         


Phe Thr Leu Thr Pro Gly Tyr Lys Thr Leu Leu Ser Arg Phe Leu Trp 
        835                 840                 845             


Trp Leu Cys Tyr Leu Leu Thr Leu Gly Glu Ala Met Val Gln Glu Trp 
    850                 855                 860                 


Ala Pro Pro Met Gln Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Ala 
865                 870                 875                 880 


Val Ala Ile Phe Tyr Pro Gly Val Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Val Leu Gly Pro Ala Tyr Leu Leu Lys Gly Ala Leu Thr Arg 
            900                 905                 910         


Val Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Met Cys Thr Met 
        915                 920                 925             


Ala Arg His Leu Ala Gly Gly Arg Tyr Val Gln Met Ala Leu Leu Ala 
    930                 935                 940                 


Leu Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Thr Pro Met 
945                 950                 955                 960 


Ser Asp Trp Ala Ala Ser Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Ile Ile Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Ala Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Ser Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Thr Ile Val Val Ser  Met Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Thr Glu Gln Ala  Gly Glu Ile Gln Val  Leu Ser Thr 
    1055                 1060                 1065             


Val Thr  Gln Ser Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Ser Arg 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Ser Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Glu  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Ala Arg Arg Arg Gly  Asp Lys Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Arg Gly His Ala  Val Gly Val Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ser  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Thr Leu  Asp Ile Val Thr Arg  Ser Pro Thr Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Val Ala Tyr 
    1235                 1240                 1245             


Ala Ala  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Leu Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Ala 
    1280                 1285                 1290             


Pro Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Gly Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Val  Asp Ser Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Thr Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Thr Pro His Pro Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly Gln Glu Gly  Glu Ile Pro Phe Tyr  Gly Arg Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ser Tyr Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Leu Asn Ser Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Val  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Ile Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Thr Gly Glu  Arg Ala Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ser Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Ser Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Val 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ser Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Val Met  Thr Ser Thr Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Val Cys  Ile Ile Gly Arg Leu  His Ile Asn Gln Arg  Ala Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Val Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Arg Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Ile 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Ser Lys  Gln Ala Gln Asp Ile  Gln Pro Thr Val Gln  Ala Ser Trp 
    1745                 1750                 1755             


Pro Lys  Val Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ser Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Leu Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Ile  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Ser Met  Glu Asp Val Val Asn  Leu Leu Pro Gly Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Pro Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Thr  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Leu Leu Gly 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Asn Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Ile Pro  Cys Gly Gly Ser Trp  Leu Arg Asp 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Thr  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Thr  Ser Lys Leu Phe Pro  Lys Met Pro Gly Leu  Pro Phe Val 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Ile 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly Asn Val 
    2030                 2035                 2040             


Arg Leu  Gly Ser Met Arg Ile  Thr Gly Pro Lys Thr  Cys Met Asn 
    2045                 2050                 2055             


Ile Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Gln 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Ala Pro  Asn Phe Lys Val Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Ala  Glu Val Thr Gln His  Gly Ser Tyr 
    2090                 2095                 2100             


His Tyr  Ile Thr Gly Leu Thr  Thr Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Leu  Pro Ser Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Thr  Pro Lys Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Ser  Phe Cys Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Asp Val Leu  Met Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Glu Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Arg Ala Thr Cys Thr  Thr His Gly 
    2210                 2215                 2220             


Lys Ala  Tyr Asp Val Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Gly Ser Lys Val  Val Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Pro Met Val  Glu Glu Arg Ser Asp  Leu Glu Pro 
    2255                 2260                 2265             


Ser Ile  Pro Ser Glu Tyr Met  Leu Pro Lys Lys Arg  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ala Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Ser  Trp Lys Arg Pro Asp  Tyr Gln Pro Ala Thr  Val Ala Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Pro Arg  Lys Thr Pro Thr Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Thr Val Gly Leu  Ser Glu Asp Ser Ile  Gly Asp Ala 
    2330                 2335                 2340             


Leu Gln  Gln Leu Ala Ile Lys  Ser Phe Gly Gln Pro  Pro Pro Ser 
    2345                 2350                 2355             


Gly Asp  Ser Gly Leu Ser Thr  Gly Ala Gly Ala Ala  Asp Ser Gly 
    2360                 2365                 2370             


Ser Gln  Thr Pro Pro Asp Glu  Leu Ala Leu Ser Glu  Thr Gly Ser 
    2375                 2380                 2385             


Ile Ser  Ser Met Pro Pro Leu  Glu Gly Glu Leu Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Pro Glu Gln Val Glu  Pro Gln Pro Pro Pro  Gln Gly Gly 
    2405                 2410                 2415             


Val Ala  Ala Pro Gly Ser Asp  Ser Gly Ser Trp Ser  Thr Cys Ser 
    2420                 2425                 2430             


Glu Glu  Asp Asp Ser Val Val  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Ser Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Leu Arg Tyr  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Cys Thr Thr Thr Lys  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Met Gln  Val Leu Asp Ser Tyr  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Lys Asp Ile Lys Leu  Ala Ala Ser Lys Val  Thr Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Met Glu Glu Ala  Cys Gln Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Arg  Ser Lys Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Gly  Arg Ala Val Asn His  Ile Lys Ser Val Trp  Lys Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Ser Glu Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Val Asp  Pro Thr Lys Gly Gly  Lys Lys Ala 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Thr Gln Lys Leu Pro  Gln Ala Val 
    2615                 2620                 2625             


Met Gly  Ala Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Gln Arg Val 
    2630                 2635                 2640             


Glu Phe  Leu Leu Lys Ala Trp  Ala Glu Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Arg Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Glu Glu  Ala His Thr Ala Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Phe Asn  Ser Lys Gly Gln Thr  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Ile  Thr Cys Tyr Val Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Ile Ala Pro Thr Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Thr Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Pro  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Gly Pro Gln Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Ala  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Ala Arg Met  Val Leu Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Met Ala Gln Asp Thr  Leu Asp Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Ser Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Asp Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Thr  Pro His Glu Leu Thr  Arg Val Ala 
    2915                 2920                 2925             


Ser Ala  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ser  Arg Gly Gly 
    2945                 2950                 2955             


Arg Ala  Ala Val Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Arg  Leu Leu Asp 
    2975                 2980                 2985             


Leu Ser  Ser Trp Phe Thr Val  Gly Ala Gly Gly Gly  Gly Ile Tyr 
    2990                 2995                 3000             


His Ser  Val Ser Arg Ala Arg  Pro Arg Leu Leu Leu  Phe Gly Leu 
    3005                 3010                 3015             


Leu Leu  Leu Phe Val Gly Val  Gly Leu Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  96
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  96

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala 
            180                 185                 190         


Glu Val Lys Asn Ile Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Thr 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Val Gly Asn Ala Ser Gln Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Arg 
    370                 375                 380                 


Thr His Thr Val Gly Gly Ser Ala Ala Gln Thr Thr Gly Arg Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Asp Met Gly Pro Arg Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr His Ser Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ser Ala Cys Arg Ser Ile Glu Ala 
    450                 455                 460                 


Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Gln Cys 
                485                 490                 495     


Gly Val Val Ser Ala Lys Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Leu Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Ser 
545                 550                 555                 560 


Gly Tyr Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Phe Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Val Ile Leu His Ala Ala Ser Ala Ala Ser Cys Asn Gly 
        755                 760                 765             


Phe Leu Tyr Phe Val Ile Phe Phe Val Ala Ala Trp Tyr Ile Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Ala Thr Tyr Ser Leu Thr Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Ser Leu Leu Leu Leu Ala Leu Pro Gln Gln Ala Tyr Ala Tyr Asp Ala 
                805                 810                 815     


Ser Val His Gly Gln Ile Gly Ala Ala Leu Leu Val Met Ile Thr Leu 
            820                 825                 830         


Phe Thr Leu Thr Pro Gly Tyr Lys Thr Leu Leu Ser Arg Phe Leu Trp 
        835                 840                 845             


Trp Leu Cys Tyr Leu Leu Thr Leu Gly Glu Ala Met Val Gln Glu Trp 
    850                 855                 860                 


Ala Pro Pro Met Gln Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Ala 
865                 870                 875                 880 


Val Ala Ile Phe Tyr Pro Gly Val Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Val Leu Gly Pro Ala Tyr Leu Leu Lys Gly Ala Leu Thr Arg 
            900                 905                 910         


Val Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Met Cys Thr Met 
        915                 920                 925             


Ala Arg His Leu Ala Gly Gly Arg Tyr Val Gln Met Ala Leu Leu Ala 
    930                 935                 940                 


Leu Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Thr Pro Met 
945                 950                 955                 960 


Ser Asp Trp Ala Ala Ser Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Ile Ile Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Ala Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Ser Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Thr Ile Val Val Ser  Met Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Thr Glu Gln Ala  Gly Glu Ile Gln Val  Leu Ser Thr 
    1055                 1060                 1065             


Val Thr  Gln Ser Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Ser Arg 
    1085                 1090                 1095             


Gly Leu  Val Thr Gln Met Tyr  Ser Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Glu  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Ala Arg Arg Arg Gly  Asp Lys Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Arg Gly His Ala  Val Gly Val Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ser  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Thr Leu  Asp Ile Val Thr Arg  Ser Pro Thr Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Val Ala Tyr 
    1235                 1240                 1245             


Ala Ala  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Leu Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Ala 
    1280                 1285                 1290             


Pro Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Gly Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Val  Asp Ser Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Thr Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Thr Pro His Pro Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly Gln Glu Gly  Glu Ile Pro Phe Tyr  Gly Arg Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ser Tyr Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Leu Asn Ser Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Val  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Ile Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Thr Gly Glu  Arg Ala Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ser Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Ser Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Val 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ser Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Val Met  Thr Ser Thr Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Val Cys  Ile Ile Gly Arg Leu  His Ile Asn Gln Arg  Ala Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Val Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Arg Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Ile 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Ser Lys  Gln Ala Gln Asp Ile  Gln Pro Thr Val Gln  Ala Ser Trp 
    1745                 1750                 1755             


Pro Lys  Val Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ser Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Leu Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Ile  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Ser Met  Glu Asp Val Val Asn  Leu Leu Pro Gly Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Pro Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Thr  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Leu Leu Gly 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Asn Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Ile Pro  Cys Gly Gly Ser Trp  Leu Arg Asp 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Thr  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Thr  Ser Lys Leu Phe Pro  Lys Met Pro Gly Leu  Pro Phe Val 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Ile 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly Asn Val 
    2030                 2035                 2040             


Arg Leu  Gly Ser Met Arg Ile  Thr Gly Pro Lys Thr  Cys Met Asn 
    2045                 2050                 2055             


Ile Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Gln 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Ala Pro  Asn Phe Lys Val Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Ala  Glu Val Thr Gln His  Gly Ser Tyr 
    2090                 2095                 2100             


His Tyr  Ile Thr Gly Leu Thr  Thr Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Leu  Pro Ser Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Thr  Pro Lys Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Ser  Phe Cys Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Asp Val Leu  Met Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Glu Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Arg Ala Thr Cys Thr  Thr His Gly 
    2210                 2215                 2220             


Lys Ala  Tyr Asp Val Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Gly Ser Lys Val  Val Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Pro Met Val  Glu Glu Arg Ser Asp  Leu Glu Pro 
    2255                 2260                 2265             


Ser Ile  Pro Ser Glu Tyr Met  Leu Pro Lys Lys Arg  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ala Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Ser  Trp Lys Arg Pro Asp  Tyr Gln Pro Ala Thr  Val Ala Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Pro Arg  Lys Thr Pro Thr Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Thr Val Gly Leu  Ser Glu Asp Ser Ile  Gly Asp Ala 
    2330                 2335                 2340             


Leu Gln  Gln Leu Ala Ile Lys  Ser Phe Gly Gln Pro  Pro Pro Ser 
    2345                 2350                 2355             


Gly Asp  Ser Gly Leu Ser Thr  Gly Ala Gly Ala Ala  Asp Ser Gly 
    2360                 2365                 2370             


Ser Gln  Thr Pro Pro Asp Glu  Leu Ala Leu Ser Glu  Thr Gly Ser 
    2375                 2380                 2385             


Ile Ser  Ser Met Pro Pro Leu  Glu Gly Glu Leu Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Pro Glu Gln Val Glu  Pro Gln Pro Pro Pro  Gln Gly Gly 
    2405                 2410                 2415             


Val Ala  Ala Pro Gly Ser Asp  Ser Gly Ser Trp Ser  Thr Cys Ser 
    2420                 2425                 2430             


Glu Glu  Asp Asp Ser Val Val  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Ser Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Leu Arg Tyr  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Cys Thr Thr Thr Lys  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Met Gln  Val Leu Asp Ser Tyr  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Lys Asp Ile Lys Leu  Ala Ala Ser Lys Val  Thr Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Met Glu Glu Ala  Cys Gln Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Arg  Ser Lys Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Gly  Arg Ala Val Asn His  Ile Lys Ser Val Trp  Lys Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Ser Glu Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Val Asp  Pro Thr Lys Gly Gly  Lys Lys Ala 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Thr Gln Lys Leu Pro  Gln Ala Val 
    2615                 2620                 2625             


Met Gly  Ala Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Gln Arg Val 
    2630                 2635                 2640             


Glu Phe  Leu Leu Lys Ala Trp  Ala Glu Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Arg Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Glu Glu  Ala His Thr Ala Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Phe Asn  Ser Lys Gly Gln Thr  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Ile  Thr Cys Tyr Val Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Ile Ala Pro Thr Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Thr Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Pro  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Gly Pro Gln Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Ala  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Ala Arg Met  Val Leu Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Met Ala Gln Asp Thr  Leu Asp Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Ser Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Asp Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Thr  Pro His Glu Leu Thr  Arg Val Ala 
    2915                 2920                 2925             


Ser Ala  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ser  Arg Gly Gly 
    2945                 2950                 2955             


Arg Ala  Ala Val Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Arg  Leu Leu Asp 
    2975                 2980                 2985             


Leu Ser  Ser Trp Phe Thr Val  Gly Ala Gly Gly Gly  Gly Ile Tyr 
    2990                 2995                 3000             


His Ser  Val Ser Arg Ala Arg  Pro Arg Leu Leu Leu  Phe Gly Leu 
    3005                 3010                 3015             


Leu Leu  Leu Phe Val Gly Val  Gly Leu Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  97
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  97

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala 
            180                 185                 190         


Glu Val Lys Asn Ile Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Thr 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Val Gly Asn Ala Ser Gln Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Arg 
    370                 375                 380                 


Thr His Thr Val Gly Gly Ser Ala Ala Gln Thr Thr Gly Arg Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Asp Met Gly Pro Arg Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr His Ser Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ser Ala Cys Arg Ser Ile Glu Ala 
    450                 455                 460                 


Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Gln Cys 
                485                 490                 495     


Gly Val Val Ser Ala Lys Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Leu Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Ser 
545                 550                 555                 560 


Gly Tyr Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Phe Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Val Ile Leu His Ala Ala Ser Ala Ala Ser Cys Asn Gly 
        755                 760                 765             


Phe Leu Tyr Phe Val Ile Phe Phe Val Ala Ala Trp Tyr Ile Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Ala Thr Tyr Ser Leu Thr Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Ser Leu Leu Leu Leu Ala Leu Pro Gln Gln Ala Tyr Ala Tyr Asp Ala 
                805                 810                 815     


Ser Val His Gly Gln Ile Gly Ala Ala Leu Leu Val Met Ile Thr Leu 
            820                 825                 830         


Phe Thr Leu Thr Pro Gly Tyr Lys Thr Leu Leu Ser Arg Phe Leu Trp 
        835                 840                 845             


Trp Leu Cys Tyr Leu Leu Thr Leu Gly Glu Ala Met Val Gln Glu Trp 
    850                 855                 860                 


Ala Pro Pro Met Gln Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Ala 
865                 870                 875                 880 


Val Ala Ile Phe Tyr Pro Gly Val Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Val Leu Gly Pro Ala Tyr Leu Leu Lys Gly Ala Leu Thr Arg 
            900                 905                 910         


Val Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Met Cys Thr Met 
        915                 920                 925             


Ala Arg His Leu Ala Gly Gly Arg Tyr Val Gln Met Ala Leu Leu Ala 
    930                 935                 940                 


Leu Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Thr Pro Met 
945                 950                 955                 960 


Ser Asp Trp Ala Ala Ser Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Ile Ile Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Ala Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Ser Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Thr Ile Val Val Ser  Met Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Thr Glu Gln Ala  Gly Glu Ile Gln Val  Leu Ser Thr 
    1055                 1060                 1065             


Val Thr  Gln Ser Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Ser Arg 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Ser Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Glu  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Ala Arg Arg Arg Gly  Asp Lys Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Arg Gly His Ala  Val Gly Val Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ser  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Thr Leu  Asp Ile Val Thr Arg  Ser Pro Thr Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Val Ala Tyr 
    1235                 1240                 1245             


Ala Ala  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Leu Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Ala 
    1280                 1285                 1290             


Pro Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Gly Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Val  Asp Ser Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Thr Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Thr Pro His Pro Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly Gln Glu Gly  Glu Ile Pro Phe Tyr  Gly Arg Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ser Tyr Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Leu Asn Ser Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Val  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Ile Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Thr Gly Glu  Arg Ala Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ser Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Ser Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Val 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ser Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Val Met  Thr Ser Thr Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Val Cys  Ile Ile Gly Arg Leu  His Ile Asn Gln Arg  Ala Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Val Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Arg Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Ile 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Ser Lys  Gln Ala Gln Asp Ile  Gln Pro Thr Val Gln  Ala Ser Trp 
    1745                 1750                 1755             


Pro Lys  Val Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ser Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Leu Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Ile  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Ser Met  Glu Asp Val Val Asn  Leu Leu Pro Gly Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Pro Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Ser His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Thr  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Leu Leu Gly 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Asn Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Ile Pro  Cys Gly Gly Ser Trp  Leu Arg Asp 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Thr  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Thr  Ser Lys Leu Phe Pro  Lys Met Pro Gly Leu  Pro Phe Val 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Ile 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly Asn Val 
    2030                 2035                 2040             


Arg Leu  Gly Ser Met Arg Ile  Thr Gly Pro Lys Thr  Cys Met Asn 
    2045                 2050                 2055             


Ile Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Gln 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Ala Pro  Asn Phe Lys Val Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Ala  Glu Val Thr Gln His  Gly Ser Tyr 
    2090                 2095                 2100             


His Tyr  Ile Thr Gly Leu Thr  Thr Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Leu  Pro Ser Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Thr  Pro Lys Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Ser  Phe Cys Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Asp Val Leu  Met Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Glu Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Arg Ala Thr Cys Thr  Thr His Gly 
    2210                 2215                 2220             


Lys Ala  Tyr Asp Val Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Gly Ser Lys Val  Val Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Pro Met Val  Glu Glu Arg Ser Asp  Leu Glu Pro 
    2255                 2260                 2265             


Ser Ile  Pro Ser Glu Tyr Met  Leu Pro Lys Lys Arg  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ala Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Ser  Trp Lys Arg Pro Asp  Tyr Gln Pro Ala Thr  Val Ala Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Pro Arg  Lys Thr Pro Thr Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Thr Val Gly Leu  Ser Glu Asp Ser Ile  Gly Asp Ala 
    2330                 2335                 2340             


Leu Gln  Gln Leu Ala Ile Lys  Ser Phe Gly Gln Pro  Pro Pro Ser 
    2345                 2350                 2355             


Gly Asp  Ser Gly Leu Ser Thr  Gly Ala Gly Ala Ala  Asp Ser Gly 
    2360                 2365                 2370             


Ser Gln  Thr Pro Pro Asp Glu  Leu Ala Leu Ser Glu  Thr Gly Ser 
    2375                 2380                 2385             


Ile Ser  Ser Met Pro Pro Leu  Glu Gly Glu Leu Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Pro Glu Gln Val Glu  Pro Gln Pro Pro Pro  Gln Gly Gly 
    2405                 2410                 2415             


Val Ala  Ala Pro Gly Ser Asp  Ser Gly Ser Trp Ser  Thr Cys Ser 
    2420                 2425                 2430             


Glu Glu  Asp Asp Ser Val Val  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Ser Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Leu Arg Tyr  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Cys Thr Thr Thr Lys  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Met Gln  Val Leu Asp Ser Tyr  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Lys Asp Ile Lys Leu  Ala Ala Ser Lys Val  Thr Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Met Glu Glu Ala  Cys Gln Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Arg  Ser Lys Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Gly  Arg Ala Val Asn His  Ile Lys Ser Val Trp  Lys Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Ser Glu Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Val Asp  Pro Thr Lys Gly Gly  Lys Lys Ala 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Thr Gln Lys Leu Pro  Gln Ala Val 
    2615                 2620                 2625             


Met Gly  Ala Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Gln Arg Val 
    2630                 2635                 2640             


Glu Phe  Leu Leu Lys Ala Trp  Ala Glu Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Arg Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Glu Glu  Ala His Thr Ala Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Phe Asn  Ser Lys Gly Gln Thr  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Ile  Thr Cys Tyr Val Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Ile Ala Pro Thr Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Thr Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Pro  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Gly Pro Gln Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Ala  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Ala Arg Met  Val Leu Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Met Ala Gln Asp Thr  Leu Asp Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Ser Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Asp Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Thr  Pro His Glu Leu Thr  Arg Val Ala 
    2915                 2920                 2925             


Ser Ala  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ser  Arg Gly Gly 
    2945                 2950                 2955             


Arg Ala  Ala Val Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Arg  Leu Leu Asp 
    2975                 2980                 2985             


Leu Ser  Ser Trp Phe Thr Val  Gly Ala Gly Gly Gly  Gly Ile Tyr 
    2990                 2995                 3000             


His Ser  Val Ser Arg Ala Arg  Pro Arg Leu Leu Leu  Phe Gly Leu 
    3005                 3010                 3015             


Leu Leu  Leu Phe Val Gly Val  Gly Leu Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  98
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  98

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala 
            180                 185                 190         


Glu Val Lys Asn Ile Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Thr 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Val Gly Asn Ala Ser Gln Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Arg 
    370                 375                 380                 


Thr His Thr Val Gly Gly Ser Ala Ala Gln Thr Thr Gly Arg Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Asp Met Gly Pro Arg Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr His Ser Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ser Ala Cys Arg Ser Ile Glu Ala 
    450                 455                 460                 


Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Gln Cys 
                485                 490                 495     


Gly Val Val Ser Ala Lys Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Leu Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Ser 
545                 550                 555                 560 


Gly Tyr Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Phe Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Val Ile Leu His Ala Ala Ser Ala Ala Ser Cys Asn Gly 
        755                 760                 765             


Phe Leu Tyr Phe Val Ile Phe Phe Val Ala Ala Trp Tyr Ile Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Ala Thr Tyr Ser Leu Thr Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Ser Leu Leu Leu Leu Ala Leu Pro Gln Gln Ala Tyr Ala Tyr Asp Ala 
                805                 810                 815     


Ser Val His Gly Gln Ile Gly Ala Ala Leu Leu Val Met Ile Thr Leu 
            820                 825                 830         


Phe Thr Leu Thr Pro Gly Tyr Lys Thr Leu Leu Ser Arg Phe Leu Trp 
        835                 840                 845             


Trp Leu Cys Tyr Leu Leu Thr Leu Gly Glu Ala Met Val Gln Glu Trp 
    850                 855                 860                 


Ala Pro Pro Met Gln Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Ala 
865                 870                 875                 880 


Val Ala Ile Phe Tyr Pro Gly Val Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Val Leu Gly Pro Ala Tyr Leu Leu Lys Gly Ala Leu Thr Arg 
            900                 905                 910         


Val Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Met Cys Thr Met 
        915                 920                 925             


Ala Arg His Leu Ala Gly Gly Arg Tyr Val Gln Met Ala Leu Leu Ala 
    930                 935                 940                 


Leu Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Thr Pro Met 
945                 950                 955                 960 


Ser Asp Trp Ala Ala Ser Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Ile Ile Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Ala Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Ser Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Thr Ile Val Val Ser  Met Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Thr Glu Gln Ala  Gly Glu Ile Gln Val  Leu Ser Thr 
    1055                 1060                 1065             


Val Thr  Gln Ser Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Ser Arg 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Ser Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Glu  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Ala Arg Arg Arg Gly  Asp Lys Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Arg Gly His Ala  Val Gly Val Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ser  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Thr Leu  Asp Ile Val Thr Arg  Ser Pro Thr Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Val Ala Tyr 
    1235                 1240                 1245             


Ala Ala  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Leu Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Ala 
    1280                 1285                 1290             


Pro Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Gly Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Val  Asp Ser Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Thr Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Thr Pro His Pro Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly Gln Glu Gly  Glu Ile Pro Phe Tyr  Gly Arg Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ser Tyr Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Leu Asn Ser Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Val  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Ile Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Thr Gly Glu  Arg Ala Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ser Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Ser Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Val 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ser Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Val Met  Thr Ser Thr Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Val Cys  Ile Ile Gly Arg Leu  His Ile Asn Gln Arg  Ala Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Val Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Arg Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Ile 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Ser Lys  Gln Ala Gln Asp Ile  Gln Pro Thr Val Gln  Ala Ser Trp 
    1745                 1750                 1755             


Pro Lys  Val Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ser Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Leu Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Ile  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Ser Met  Glu Asp Val Val Asn  Leu Leu Pro Gly Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Pro Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Thr His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Thr  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Leu Leu Gly 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Asn Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Ile Pro  Cys Gly Gly Ser Trp  Leu Arg Asp 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Thr  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Thr  Ser Lys Leu Phe Pro  Lys Met Pro Gly Leu  Pro Phe Val 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Ile 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly Asn Val 
    2030                 2035                 2040             


Arg Leu  Gly Ser Met Arg Ile  Thr Gly Pro Lys Thr  Cys Met Asn 
    2045                 2050                 2055             


Ile Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Gln 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Ala Pro  Asn Phe Lys Val Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Ala  Glu Val Thr Gln His  Gly Ser Tyr 
    2090                 2095                 2100             


His Tyr  Ile Thr Gly Leu Thr  Thr Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Leu  Pro Ser Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Thr  Pro Lys Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Ser  Phe Cys Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Asp Val Leu  Met Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Glu Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Arg Ala Thr Cys Thr  Thr His Gly 
    2210                 2215                 2220             


Lys Ala  Tyr Asp Val Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Gly Ser Lys Val  Val Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Pro Met Val  Glu Glu Arg Ser Asp  Leu Glu Pro 
    2255                 2260                 2265             


Ser Ile  Pro Ser Glu Tyr Met  Leu Pro Lys Lys Arg  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ala Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Ser  Trp Lys Arg Pro Asp  Tyr Gln Pro Ala Thr  Val Ala Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Pro Arg  Lys Thr Pro Thr Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Thr Val Gly Leu  Ser Glu Asp Ser Ile  Gly Asp Ala 
    2330                 2335                 2340             


Leu Gln  Gln Leu Ala Ile Lys  Ser Phe Gly Gln Pro  Pro Pro Ser 
    2345                 2350                 2355             


Gly Asp  Ser Gly Leu Ser Thr  Gly Ala Gly Ala Ala  Asp Ser Gly 
    2360                 2365                 2370             


Ser Gln  Thr Pro Pro Asp Glu  Leu Ala Leu Ser Glu  Thr Gly Ser 
    2375                 2380                 2385             


Ile Ser  Ser Met Pro Pro Leu  Glu Gly Glu Leu Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Pro Glu Gln Val Glu  Pro Gln Pro Pro Pro  Gln Gly Gly 
    2405                 2410                 2415             


Val Ala  Ala Pro Gly Ser Asp  Ser Gly Ser Trp Ser  Thr Cys Ser 
    2420                 2425                 2430             


Glu Glu  Asp Asp Ser Val Val  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Ser Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Leu Arg Tyr  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Cys Thr Thr Thr Lys  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Met Gln  Val Leu Asp Ser Tyr  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Lys Asp Ile Lys Leu  Ala Ala Ser Lys Val  Thr Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Met Glu Glu Ala  Cys Gln Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Arg  Ser Lys Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Gly  Arg Ala Val Asn His  Ile Lys Ser Val Trp  Lys Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Ser Glu Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Val Asp  Pro Thr Lys Gly Gly  Lys Lys Ala 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Thr Gln Lys Leu Pro  Gln Ala Val 
    2615                 2620                 2625             


Met Gly  Ala Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Gln Arg Val 
    2630                 2635                 2640             


Glu Phe  Leu Leu Lys Ala Trp  Ala Glu Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Arg Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Glu Glu  Ala His Thr Ala Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Phe Asn  Ser Lys Gly Gln Thr  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Ile  Thr Cys Tyr Val Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Ile Ala Pro Thr Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Thr Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Pro  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Gly Pro Gln Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Ala  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Ala Arg Met  Val Leu Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Met Ala Gln Asp Thr  Leu Asp Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Ser Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Asp Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Thr  Pro His Glu Leu Thr  Arg Val Ala 
    2915                 2920                 2925             


Ser Ala  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ser  Arg Gly Gly 
    2945                 2950                 2955             


Arg Ala  Ala Val Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Arg  Leu Leu Asp 
    2975                 2980                 2985             


Leu Ser  Ser Trp Phe Thr Val  Gly Ala Gly Gly Gly  Gly Ile Tyr 
    2990                 2995                 3000             


His Ser  Val Ser Arg Ala Arg  Pro Arg Leu Leu Leu  Phe Gly Leu 
    3005                 3010                 3015             


Leu Leu  Leu Phe Val Gly Val  Gly Leu Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  99
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  99

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala 
            180                 185                 190         


Glu Val Lys Asn Ile Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Thr 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Val Gly Asn Ala Ser Gln Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Arg 
    370                 375                 380                 


Thr His Thr Val Gly Gly Ser Ala Ala Gln Thr Thr Gly Arg Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Asp Met Gly Pro Arg Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr His Ser Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ser Ala Cys Arg Ser Ile Glu Ala 
    450                 455                 460                 


Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Gln Cys 
                485                 490                 495     


Gly Val Val Ser Ala Lys Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Leu Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Ser 
545                 550                 555                 560 


Gly Tyr Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Phe Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Val Ile Leu His Ala Ala Ser Ala Ala Ser Cys Asn Gly 
        755                 760                 765             


Phe Leu Tyr Phe Val Ile Phe Ser Val Ala Ala Trp Tyr Ile Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Ala Thr Tyr Ser Leu Thr Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Ser Leu Leu Leu Leu Ala Leu Pro Gln Gln Ala Tyr Ala Tyr Asp Ala 
                805                 810                 815     


Ser Val His Gly Gln Ile Gly Ala Ala Leu Leu Val Met Ile Thr Leu 
            820                 825                 830         


Phe Thr Leu Thr Pro Gly Tyr Lys Thr Leu Leu Ser Arg Phe Leu Trp 
        835                 840                 845             


Trp Leu Cys Tyr Leu Leu Thr Leu Gly Glu Ala Met Val Gln Glu Trp 
    850                 855                 860                 


Ala Pro Pro Met Gln Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Ala 
865                 870                 875                 880 


Val Ala Ile Phe Tyr Pro Gly Val Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Val Leu Gly Pro Ala Tyr Leu Leu Lys Gly Ala Leu Thr Arg 
            900                 905                 910         


Val Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Met Cys Thr Met 
        915                 920                 925             


Ala Arg His Leu Ala Gly Gly Arg Tyr Val Gln Met Ala Leu Leu Ala 
    930                 935                 940                 


Leu Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Thr Pro Met 
945                 950                 955                 960 


Ser Asp Trp Ala Ala Ser Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Ile Ile Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Ala Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Ser Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Thr Ile Val Val Ser  Met Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Thr Glu Gln Ala  Gly Glu Ile Gln Val  Leu Ser Thr 
    1055                 1060                 1065             


Val Thr  Gln Ser Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Ser Arg 
    1085                 1090                 1095             


Gly Leu  Val Thr Gln Met Tyr  Ser Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Glu  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Ala Arg Arg Arg Gly  Asp Lys Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Arg Gly His Ala  Val Gly Val Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ser  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Thr Leu  Asp Ile Val Thr Arg  Ser Pro Thr Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Val Ala Tyr 
    1235                 1240                 1245             


Ala Ala  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Leu Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Ala 
    1280                 1285                 1290             


Pro Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Gly Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Val  Asp Ser Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Thr Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Thr Pro His Pro Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly Gln Glu Gly  Glu Ile Pro Phe Tyr  Gly Arg Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ser Tyr Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Leu Asn Ser Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Val  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Ile Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Thr Gly Glu  Arg Ala Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ser Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Ser Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Val 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ser Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Val Met  Thr Ser Thr Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Val Cys  Ile Ile Gly Arg Leu  His Ile Asn Gln Arg  Ala Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Val Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Arg Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Ile 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Ser Lys  Gln Ala Gln Asp Ile  Gln Pro Thr Val Gln  Ala Ser Trp 
    1745                 1750                 1755             


Pro Lys  Val Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ser Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Leu Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Ile  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Ser Met  Glu Asp Val Val Asn  Leu Leu Pro Gly Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Pro Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Thr  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Leu Leu Gly 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Asn Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Ile Pro  Cys Gly Gly Ser Trp  Leu Arg Asp 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Thr  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Thr  Ser Lys Leu Phe Pro  Lys Met Pro Gly Leu  Pro Phe Val 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Ile 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly Asn Val 
    2030                 2035                 2040             


Arg Leu  Gly Ser Met Arg Ile  Thr Gly Pro Lys Thr  Cys Met Asn 
    2045                 2050                 2055             


Ile Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Gln 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Ala Pro  Asn Phe Lys Val Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Ala  Glu Val Thr Gln His  Gly Ser Tyr 
    2090                 2095                 2100             


His Tyr  Ile Thr Gly Leu Thr  Thr Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Leu  Pro Ser Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Thr  Pro Lys Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Ser  Phe Cys Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Asp Val Leu  Met Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Glu Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Arg Ala Thr Cys Thr  Thr His Gly 
    2210                 2215                 2220             


Lys Ala  Tyr Asp Val Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Gly Ser Lys Val  Val Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Pro Met Val  Glu Glu Arg Ser Asp  Leu Glu Pro 
    2255                 2260                 2265             


Ser Ile  Pro Ser Glu Tyr Met  Leu Pro Lys Lys Arg  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ala Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Ser  Trp Lys Arg Pro Asp  Tyr Gln Pro Ala Thr  Val Ala Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Pro Arg  Lys Thr Pro Thr Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Thr Val Gly Leu  Ser Glu Asp Ser Ile  Gly Asp Ala 
    2330                 2335                 2340             


Leu Gln  Gln Leu Ala Ile Lys  Ser Phe Gly Gln Pro  Pro Pro Ser 
    2345                 2350                 2355             


Gly Asp  Ser Gly Leu Ser Thr  Gly Ala Gly Ala Ala  Asp Ser Gly 
    2360                 2365                 2370             


Ser Gln  Thr Pro Pro Asp Glu  Leu Ala Leu Ser Glu  Thr Gly Ser 
    2375                 2380                 2385             


Ile Ser  Ser Met Pro Pro Leu  Glu Gly Glu Leu Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Pro Glu Gln Val Glu  Pro Gln Pro Pro Pro  Gln Gly Gly 
    2405                 2410                 2415             


Val Ala  Ala Pro Gly Ser Asp  Ser Gly Ser Trp Ser  Thr Cys Ser 
    2420                 2425                 2430             


Glu Glu  Asp Asp Ser Val Val  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Ser Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Leu Arg Tyr  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Cys Thr Thr Thr Lys  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Met Gln  Val Leu Asp Ser Tyr  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Lys Asp Ile Lys Leu  Ala Ala Ser Lys Val  Thr Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Met Glu Glu Ala  Cys Gln Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Arg  Ser Lys Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Gly  Arg Ala Val Asn His  Ile Lys Ser Val Trp  Lys Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Ser Glu Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Val Asp  Pro Thr Lys Gly Gly  Lys Lys Ala 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Thr Gln Lys Leu Pro  Gln Ala Val 
    2615                 2620                 2625             


Met Gly  Ala Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Gln Arg Val 
    2630                 2635                 2640             


Glu Phe  Leu Leu Lys Ala Trp  Ala Glu Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Arg Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Glu Glu  Ala His Thr Ala Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Phe Asn  Ser Lys Gly Gln Thr  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Ile  Thr Cys Tyr Val Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Ile Ala Pro Thr Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Thr Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Pro  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Gly Pro Gln Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Ala  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Ala Arg Met  Val Leu Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Met Ala Gln Asp Thr  Leu Asp Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Ser Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Asp Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Thr  Pro His Glu Leu Thr  Arg Val Ala 
    2915                 2920                 2925             


Ser Ala  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ser  Arg Gly Gly 
    2945                 2950                 2955             


Arg Ala  Ala Val Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Arg  Leu Leu Asp 
    2975                 2980                 2985             


Leu Ser  Ser Trp Phe Thr Val  Gly Ala Gly Gly Gly  Gly Ile Tyr 
    2990                 2995                 3000             


His Ser  Val Ser Arg Ala Arg  Pro Arg Leu Leu Leu  Phe Gly Leu 
    3005                 3010                 3015             


Leu Leu  Leu Phe Val Gly Val  Gly Leu Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  100
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  100

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala 
            180                 185                 190         


Glu Val Lys Asn Ile Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Thr 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Val Gly Asn Ala Ser Gln Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Arg 
    370                 375                 380                 


Thr His Thr Val Gly Gly Ser Ala Ala Gln Thr Thr Gly Arg Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Asp Met Gly Pro Arg Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr His Ser Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ser Ala Cys Arg Ser Ile Glu Ala 
    450                 455                 460                 


Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Gln Cys 
                485                 490                 495     


Gly Val Val Ser Ala Lys Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Leu Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Ser 
545                 550                 555                 560 


Gly Tyr Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Phe Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Val Ile Leu His Ala Ala Ser Ala Ala Ser Cys Asn Gly 
        755                 760                 765             


Phe Leu Tyr Phe Val Ile Phe Ser Val Ala Ala Trp Tyr Ile Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Ala Thr Tyr Ser Leu Thr Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Ser Leu Leu Leu Leu Ala Leu Pro Gln Gln Ala Tyr Ala Tyr Asp Ala 
                805                 810                 815     


Ser Val His Gly Gln Ile Gly Ala Ala Leu Leu Val Met Ile Thr Leu 
            820                 825                 830         


Phe Thr Leu Thr Pro Gly Tyr Lys Thr Leu Leu Ser Arg Phe Leu Trp 
        835                 840                 845             


Trp Leu Cys Tyr Leu Leu Thr Leu Gly Glu Ala Met Val Gln Glu Trp 
    850                 855                 860                 


Ala Pro Pro Met Gln Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Ala 
865                 870                 875                 880 


Val Ala Ile Phe Tyr Pro Gly Val Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Val Leu Gly Pro Ala Tyr Leu Leu Lys Gly Ala Leu Thr Arg 
            900                 905                 910         


Val Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Met Cys Thr Met 
        915                 920                 925             


Ala Arg His Leu Ala Gly Gly Arg Tyr Val Gln Met Ala Leu Leu Ala 
    930                 935                 940                 


Leu Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Thr Pro Met 
945                 950                 955                 960 


Ser Asp Trp Ala Ala Ser Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Ile Ile Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Ala Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Ser Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Thr Ile Val Val Ser  Met Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Thr Glu Gln Ala  Gly Glu Ile Gln Val  Leu Ser Thr 
    1055                 1060                 1065             


Val Thr  Gln Ser Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Ser Arg 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Ser Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Glu  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Ala Arg Arg Arg Gly  Asp Lys Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Arg Gly His Ala  Val Gly Val Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ser  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Thr Leu  Asp Ile Val Thr Arg  Ser Pro Thr Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Val Ala Tyr 
    1235                 1240                 1245             


Ala Ala  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Leu Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Ala 
    1280                 1285                 1290             


Pro Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Gly Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Val  Asp Ser Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Thr Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Thr Pro His Pro Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly Gln Glu Gly  Glu Ile Pro Phe Tyr  Gly Arg Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ser Tyr Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Leu Asn Ser Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Val  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Ile Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Thr Gly Glu  Arg Ala Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ser Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Ser Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Val 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ser Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Val Met  Thr Ser Thr Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Val Cys  Ile Ile Gly Arg Leu  His Ile Asn Gln Arg  Ala Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Val Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Arg Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Ile 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Ser Lys  Gln Ala Gln Asp Ile  Gln Pro Thr Val Gln  Ala Ser Trp 
    1745                 1750                 1755             


Pro Lys  Val Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ser Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Leu Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Ile  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Ser Met  Glu Asp Val Val Asn  Leu Leu Pro Gly Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Pro Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Ser His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Thr  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Leu Leu Gly 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Asn Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Ile Pro  Cys Gly Gly Ser Trp  Leu Arg Asp 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Thr  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Thr  Ser Lys Leu Phe Pro  Lys Met Pro Gly Leu  Pro Phe Val 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Ile 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly Asn Val 
    2030                 2035                 2040             


Arg Leu  Gly Ser Met Arg Ile  Thr Gly Pro Lys Thr  Cys Met Asn 
    2045                 2050                 2055             


Ile Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Gln 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Ala Pro  Asn Phe Lys Val Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Ala  Glu Val Thr Gln His  Gly Ser Tyr 
    2090                 2095                 2100             


His Tyr  Ile Thr Gly Leu Thr  Thr Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Leu  Pro Ser Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Thr  Pro Lys Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Ser  Phe Cys Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Asp Val Leu  Met Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Glu Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Arg Ala Thr Cys Thr  Thr His Gly 
    2210                 2215                 2220             


Lys Ala  Tyr Asp Val Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Gly Ser Lys Val  Val Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Pro Met Val  Glu Glu Arg Ser Asp  Leu Glu Pro 
    2255                 2260                 2265             


Ser Ile  Pro Ser Glu Tyr Met  Leu Pro Lys Lys Arg  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ala Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Ser  Trp Lys Arg Pro Asp  Tyr Gln Pro Ala Thr  Val Ala Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Pro Arg  Lys Thr Pro Thr Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Thr Val Gly Leu  Ser Glu Asp Ser Ile  Gly Asp Ala 
    2330                 2335                 2340             


Leu Gln  Gln Leu Ala Ile Lys  Ser Phe Gly Gln Pro  Pro Pro Ser 
    2345                 2350                 2355             


Gly Asp  Ser Gly Leu Ser Thr  Gly Ala Gly Ala Ala  Asp Ser Gly 
    2360                 2365                 2370             


Ser Gln  Thr Pro Pro Asp Glu  Leu Ala Leu Ser Glu  Thr Gly Ser 
    2375                 2380                 2385             


Ile Ser  Ser Met Pro Pro Leu  Glu Gly Glu Leu Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Pro Glu Gln Val Glu  Pro Gln Pro Pro Pro  Gln Gly Gly 
    2405                 2410                 2415             


Val Ala  Ala Pro Gly Ser Asp  Ser Gly Ser Trp Ser  Thr Cys Ser 
    2420                 2425                 2430             


Glu Glu  Asp Asp Ser Val Val  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Ser Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Leu Arg Tyr  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Cys Thr Thr Thr Lys  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Met Gln  Val Leu Asp Ser Tyr  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Lys Asp Ile Lys Leu  Ala Ala Ser Lys Val  Thr Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Met Glu Glu Ala  Cys Gln Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Arg  Ser Lys Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Gly  Arg Ala Val Asn His  Ile Lys Ser Val Trp  Lys Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Ser Glu Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Val Asp  Pro Thr Lys Gly Gly  Lys Lys Ala 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Thr Gln Lys Leu Pro  Gln Ala Val 
    2615                 2620                 2625             


Met Gly  Ala Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Gln Arg Val 
    2630                 2635                 2640             


Glu Phe  Leu Leu Lys Ala Trp  Ala Glu Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Arg Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Glu Glu  Ala His Thr Ala Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Phe Asn  Ser Lys Gly Gln Thr  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Ile  Thr Cys Tyr Val Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Ile Ala Pro Thr Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Thr Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Pro  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Gly Pro Gln Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Ala  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Ala Arg Met  Val Leu Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Met Ala Gln Asp Thr  Leu Asp Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Ser Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Asp Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Thr  Pro His Glu Leu Thr  Arg Val Ala 
    2915                 2920                 2925             


Ser Ala  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ser  Arg Gly Gly 
    2945                 2950                 2955             


Arg Ala  Ala Val Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Arg  Leu Leu Asp 
    2975                 2980                 2985             


Leu Ser  Ser Trp Phe Thr Val  Gly Ala Gly Gly Gly  Gly Ile Tyr 
    2990                 2995                 3000             


His Ser  Val Ser Arg Ala Arg  Pro Arg Leu Leu Leu  Phe Gly Leu 
    3005                 3010                 3015             


Leu Leu  Leu Phe Val Gly Val  Gly Leu Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  101
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  101

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala 
            180                 185                 190         


Glu Val Lys Asn Ile Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Thr 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Val Gly Asn Ala Ser Gln Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Arg 
    370                 375                 380                 


Thr His Thr Val Gly Gly Ser Ala Ala Gln Thr Thr Gly Arg Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Asp Met Gly Pro Arg Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr His Ser Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ser Ala Cys Arg Ser Ile Glu Ala 
    450                 455                 460                 


Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Gln Cys 
                485                 490                 495     


Gly Val Val Ser Ala Lys Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Leu Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Ser 
545                 550                 555                 560 


Gly Tyr Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Phe Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Val Ile Leu His Ala Ala Ser Ala Ala Ser Cys Asn Gly 
        755                 760                 765             


Phe Leu Tyr Phe Val Ile Phe Ser Val Ala Ala Trp Tyr Ile Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Ala Thr Tyr Ser Leu Thr Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Ser Leu Leu Leu Leu Ala Leu Pro Gln Gln Ala Tyr Ala Tyr Asp Ala 
                805                 810                 815     


Ser Val His Gly Gln Ile Gly Ala Ala Leu Leu Val Met Ile Thr Leu 
            820                 825                 830         


Phe Thr Leu Thr Pro Gly Tyr Lys Thr Leu Leu Ser Arg Phe Leu Trp 
        835                 840                 845             


Trp Leu Cys Tyr Leu Leu Thr Leu Gly Glu Ala Met Val Gln Glu Trp 
    850                 855                 860                 


Ala Pro Pro Met Gln Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Ala 
865                 870                 875                 880 


Val Ala Ile Phe Tyr Pro Gly Val Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Val Leu Gly Pro Ala Tyr Leu Leu Lys Gly Ala Leu Thr Arg 
            900                 905                 910         


Val Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Met Cys Thr Met 
        915                 920                 925             


Ala Arg His Leu Ala Gly Gly Arg Tyr Val Gln Met Ala Leu Leu Ala 
    930                 935                 940                 


Leu Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Thr Pro Met 
945                 950                 955                 960 


Ser Asp Trp Ala Ala Ser Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Ile Ile Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Ala Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Ser Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Thr Ile Val Val Ser  Met Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Thr Glu Gln Ala  Gly Glu Ile Gln Val  Leu Ser Thr 
    1055                 1060                 1065             


Val Thr  Gln Ser Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Ser Arg 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Ser Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Glu  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Ala Arg Arg Arg Gly  Asp Lys Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Arg Gly His Ala  Val Gly Val Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ser  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Thr Leu  Asp Ile Val Thr Arg  Ser Pro Thr Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Val Ala Tyr 
    1235                 1240                 1245             


Ala Ala  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Leu Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Ala 
    1280                 1285                 1290             


Pro Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Gly Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Val  Asp Ser Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Thr Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Thr Pro His Pro Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly Gln Glu Gly  Glu Ile Pro Phe Tyr  Gly Arg Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ser Tyr Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Leu Asn Ser Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Val  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Ile Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Thr Gly Glu  Arg Ala Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ser Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Ser Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Val 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ser Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Val Met  Thr Ser Thr Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Val Cys  Ile Ile Gly Arg Leu  His Ile Asn Gln Arg  Ala Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Val Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Arg Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Ile 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Ser Lys  Gln Ala Gln Asp Ile  Gln Pro Thr Val Gln  Ala Ser Trp 
    1745                 1750                 1755             


Pro Lys  Val Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ser Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Leu Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Ile  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Ser Met  Glu Asp Val Val Asn  Leu Leu Pro Gly Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Pro Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Thr His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Thr  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Leu Leu Gly 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Asn Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Ile Pro  Cys Gly Gly Ser Trp  Leu Arg Asp 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Thr  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Thr  Ser Lys Leu Phe Pro  Lys Met Pro Gly Leu  Pro Phe Val 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Ile 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly Asn Val 
    2030                 2035                 2040             


Arg Leu  Gly Ser Met Arg Ile  Thr Gly Pro Lys Thr  Cys Met Asn 
    2045                 2050                 2055             


Ile Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Gln 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Ala Pro  Asn Phe Lys Val Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Ala  Glu Val Thr Gln His  Gly Ser Tyr 
    2090                 2095                 2100             


His Tyr  Ile Thr Gly Leu Thr  Thr Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Leu  Pro Ser Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Thr  Pro Lys Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Ser  Phe Cys Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Asp Val Leu  Met Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Glu Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Arg Ala Thr Cys Thr  Thr His Gly 
    2210                 2215                 2220             


Lys Ala  Tyr Asp Val Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Gly Ser Lys Val  Val Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Pro Met Val  Glu Glu Arg Ser Asp  Leu Glu Pro 
    2255                 2260                 2265             


Ser Ile  Pro Ser Glu Tyr Met  Leu Pro Lys Lys Arg  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ala Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Ser  Trp Lys Arg Pro Asp  Tyr Gln Pro Ala Thr  Val Ala Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Pro Arg  Lys Thr Pro Thr Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Thr Val Gly Leu  Ser Glu Asp Ser Ile  Gly Asp Ala 
    2330                 2335                 2340             


Leu Gln  Gln Leu Ala Ile Lys  Ser Phe Gly Gln Pro  Pro Pro Ser 
    2345                 2350                 2355             


Gly Asp  Ser Gly Leu Ser Thr  Gly Ala Gly Ala Ala  Asp Ser Gly 
    2360                 2365                 2370             


Ser Gln  Thr Pro Pro Asp Glu  Leu Ala Leu Ser Glu  Thr Gly Ser 
    2375                 2380                 2385             


Ile Ser  Ser Met Pro Pro Leu  Glu Gly Glu Leu Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Pro Glu Gln Val Glu  Pro Gln Pro Pro Pro  Gln Gly Gly 
    2405                 2410                 2415             


Val Ala  Ala Pro Gly Ser Asp  Ser Gly Ser Trp Ser  Thr Cys Ser 
    2420                 2425                 2430             


Glu Glu  Asp Asp Ser Val Val  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Ser Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Leu Arg Tyr  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Cys Thr Thr Thr Lys  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Met Gln  Val Leu Asp Ser Tyr  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Lys Asp Ile Lys Leu  Ala Ala Ser Lys Val  Thr Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Met Glu Glu Ala  Cys Gln Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Arg  Ser Lys Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Gly  Arg Ala Val Asn His  Ile Lys Ser Val Trp  Lys Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Ser Glu Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Val Asp  Pro Thr Lys Gly Gly  Lys Lys Ala 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Thr Gln Lys Leu Pro  Gln Ala Val 
    2615                 2620                 2625             


Met Gly  Ala Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Gln Arg Val 
    2630                 2635                 2640             


Glu Phe  Leu Leu Lys Ala Trp  Ala Glu Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Arg Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Glu Glu  Ala His Thr Ala Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Phe Asn  Ser Lys Gly Gln Thr  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Ile  Thr Cys Tyr Val Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Ile Ala Pro Thr Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Thr Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Pro  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Gly Pro Gln Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Ala  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Ala Arg Met  Val Leu Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Met Ala Gln Asp Thr  Leu Asp Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Ser Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Asp Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Thr  Pro His Glu Leu Thr  Arg Val Ala 
    2915                 2920                 2925             


Ser Ala  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ser  Arg Gly Gly 
    2945                 2950                 2955             


Arg Ala  Ala Val Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Arg  Leu Leu Asp 
    2975                 2980                 2985             


Leu Ser  Ser Trp Phe Thr Val  Gly Ala Gly Gly Gly  Gly Ile Tyr 
    2990                 2995                 3000             


His Ser  Val Ser Arg Ala Arg  Pro Arg Leu Leu Leu  Phe Gly Leu 
    3005                 3010                 3015             


Leu Leu  Leu Phe Val Gly Val  Gly Leu Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  102
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  102

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala 
            180                 185                 190         


Glu Val Lys Asn Ile Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Thr 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Val Gly Asn Ala Ser Gln Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Arg 
    370                 375                 380                 


Thr His Thr Val Gly Gly Ser Ala Ala Gln Thr Thr Gly Arg Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Asp Met Gly Pro Arg Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr His Ser Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ser Ala Cys Arg Ser Ile Glu Ala 
    450                 455                 460                 


Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Gln Cys 
                485                 490                 495     


Gly Val Val Ser Ala Lys Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Leu Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Ser 
545                 550                 555                 560 


Gly Tyr Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Phe Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Val Ile Leu His Ala Ala Ser Ala Ala Ser Cys Asn Gly 
        755                 760                 765             


Phe Leu Tyr Phe Val Ile Phe Phe Val Ala Ala Trp Tyr Ile Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Ala Thr Tyr Ser Leu Thr Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Ser Leu Leu Leu Leu Ala Leu Pro Gln Gln Ala Tyr Ala Tyr Asp Ala 
                805                 810                 815     


Ser Val His Gly Gln Ile Gly Ala Ala Leu Leu Val Met Ile Thr Leu 
            820                 825                 830         


Phe Thr Leu Thr Pro Gly Tyr Lys Thr Leu Leu Ser Arg Phe Leu Trp 
        835                 840                 845             


Trp Leu Cys Tyr Leu Leu Thr Leu Gly Glu Ala Met Val Gln Glu Trp 
    850                 855                 860                 


Ala Pro Pro Met Gln Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Ala 
865                 870                 875                 880 


Val Ala Ile Phe Tyr Pro Gly Val Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Val Leu Gly Pro Ala Tyr Leu Leu Lys Gly Ala Leu Thr Arg 
            900                 905                 910         


Val Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Met Cys Thr Met 
        915                 920                 925             


Ala Arg His Leu Ala Gly Gly Arg Tyr Val Gln Met Ala Leu Leu Ala 
    930                 935                 940                 


Leu Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Thr Pro Met 
945                 950                 955                 960 


Ser Asp Trp Ala Ala Ser Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Ile Ile Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Ala Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Ser Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Thr Ile Val Val Ser  Met Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Thr Glu Gln Ala  Gly Glu Ile Gln Val  Leu Ser Thr 
    1055                 1060                 1065             


Val Thr  Gln Ser Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Ser Arg 
    1085                 1090                 1095             


Gly Leu  Val Thr Gln Met Tyr  Ser Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Glu  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Ala Arg Arg Arg Gly  Asp Lys Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Arg Gly His Ala  Val Gly Val Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ser  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Thr Leu  Asp Ile Val Thr Arg  Ser Pro Thr Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Val Ala Tyr 
    1235                 1240                 1245             


Ala Ala  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Leu Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Ala 
    1280                 1285                 1290             


Pro Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Gly Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Val  Asp Ser Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Thr Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Thr Pro His Pro Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly Gln Glu Gly  Glu Ile Pro Phe Tyr  Gly Arg Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ser Tyr Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Leu Asn Ser Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Val  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Ile Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Thr Gly Glu  Arg Ala Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ser Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Ser Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Val 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ser Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Val Met  Thr Ser Thr Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Val Cys  Ile Ile Gly Arg Leu  His Ile Asn Gln Arg  Ala Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Val Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Arg Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Ile 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Ser Lys  Gln Ala Gln Asp Ile  Gln Pro Thr Val Gln  Ala Ser Trp 
    1745                 1750                 1755             


Pro Lys  Val Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ser Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Leu Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Ile  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Ser Met  Glu Asp Val Val Asn  Leu Leu Pro Gly Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Pro Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Ser His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Thr  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Leu Leu Gly 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Asn Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Ile Pro  Cys Gly Gly Ser Trp  Leu Arg Asp 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Thr  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Thr  Ser Lys Leu Phe Pro  Lys Met Pro Gly Leu  Pro Phe Val 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Ile 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly Asn Val 
    2030                 2035                 2040             


Arg Leu  Gly Ser Met Arg Ile  Thr Gly Pro Lys Thr  Cys Met Asn 
    2045                 2050                 2055             


Ile Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Gln 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Ala Pro  Asn Phe Lys Val Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Ala  Glu Val Thr Gln His  Gly Ser Tyr 
    2090                 2095                 2100             


His Tyr  Ile Thr Gly Leu Thr  Thr Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Leu  Pro Ser Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Thr  Pro Lys Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Ser  Phe Cys Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Asp Val Leu  Met Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Glu Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Arg Ala Thr Cys Thr  Thr His Gly 
    2210                 2215                 2220             


Lys Ala  Tyr Asp Val Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Gly Ser Lys Val  Val Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Pro Met Val  Glu Glu Arg Ser Asp  Leu Glu Pro 
    2255                 2260                 2265             


Ser Ile  Pro Ser Glu Tyr Met  Leu Pro Lys Lys Arg  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ala Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Ser  Trp Lys Arg Pro Asp  Tyr Gln Pro Ala Thr  Val Ala Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Pro Arg  Lys Thr Pro Thr Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Thr Val Gly Leu  Ser Glu Asp Ser Ile  Gly Asp Ala 
    2330                 2335                 2340             


Leu Gln  Gln Leu Ala Ile Lys  Ser Phe Gly Gln Pro  Pro Pro Ser 
    2345                 2350                 2355             


Gly Asp  Ser Gly Leu Ser Thr  Gly Ala Gly Ala Ala  Asp Ser Gly 
    2360                 2365                 2370             


Ser Gln  Thr Pro Pro Asp Glu  Leu Ala Leu Ser Glu  Thr Gly Ser 
    2375                 2380                 2385             


Ile Ser  Ser Met Pro Pro Leu  Glu Gly Glu Leu Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Pro Glu Gln Val Glu  Pro Gln Pro Pro Pro  Gln Gly Gly 
    2405                 2410                 2415             


Val Ala  Ala Pro Gly Ser Asp  Ser Gly Ser Trp Ser  Thr Cys Ser 
    2420                 2425                 2430             


Glu Glu  Asp Asp Ser Val Val  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Ser Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Leu Arg Tyr  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Cys Thr Thr Thr Lys  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Met Gln  Val Leu Asp Ser Tyr  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Lys Asp Ile Lys Leu  Ala Ala Ser Lys Val  Thr Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Met Glu Glu Ala  Cys Gln Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Arg  Ser Lys Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Gly  Arg Ala Val Asn His  Ile Lys Ser Val Trp  Lys Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Ser Glu Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Val Asp  Pro Thr Lys Gly Gly  Lys Lys Ala 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Thr Gln Lys Leu Pro  Gln Ala Val 
    2615                 2620                 2625             


Met Gly  Ala Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Gln Arg Val 
    2630                 2635                 2640             


Glu Phe  Leu Leu Lys Ala Trp  Ala Glu Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Arg Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Glu Glu  Ala His Thr Ala Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Phe Asn  Ser Lys Gly Gln Thr  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Ile  Thr Cys Tyr Val Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Ile Ala Pro Thr Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Thr Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Pro  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Gly Pro Gln Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Ala  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Ala Arg Met  Val Leu Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Met Ala Gln Asp Thr  Leu Asp Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Ser Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Asp Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Thr  Pro His Glu Leu Thr  Arg Val Ala 
    2915                 2920                 2925             


Ser Ala  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ser  Arg Gly Gly 
    2945                 2950                 2955             


Arg Ala  Ala Val Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Arg  Leu Leu Asp 
    2975                 2980                 2985             


Leu Ser  Ser Trp Phe Thr Val  Gly Ala Gly Gly Gly  Gly Ile Tyr 
    2990                 2995                 3000             


His Ser  Val Ser Arg Ala Arg  Pro Arg Leu Leu Leu  Phe Gly Leu 
    3005                 3010                 3015             


Leu Leu  Leu Phe Val Gly Val  Gly Leu Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  103
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  103

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala 
            180                 185                 190         


Glu Val Lys Asn Ile Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Thr 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Val Gly Asn Ala Ser Gln Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Arg 
    370                 375                 380                 


Thr His Thr Val Gly Gly Ser Ala Ala Gln Thr Thr Gly Arg Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Asp Met Gly Pro Arg Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr His Ser Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ser Ala Cys Arg Ser Ile Glu Ala 
    450                 455                 460                 


Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Gln Cys 
                485                 490                 495     


Gly Val Val Ser Ala Lys Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Leu Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Ser 
545                 550                 555                 560 


Gly Tyr Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Phe Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Val Ile Leu His Ala Ala Ser Ala Ala Ser Cys Asn Gly 
        755                 760                 765             


Phe Leu Tyr Phe Val Ile Phe Phe Val Ala Ala Trp Tyr Ile Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Ala Thr Tyr Ser Leu Thr Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Ser Leu Leu Leu Leu Ala Leu Pro Gln Gln Ala Tyr Ala Tyr Asp Ala 
                805                 810                 815     


Ser Val His Gly Gln Ile Gly Ala Ala Leu Leu Val Met Ile Thr Leu 
            820                 825                 830         


Phe Thr Leu Thr Pro Gly Tyr Lys Thr Leu Leu Ser Arg Phe Leu Trp 
        835                 840                 845             


Trp Leu Cys Tyr Leu Leu Thr Leu Gly Glu Ala Met Val Gln Glu Trp 
    850                 855                 860                 


Ala Pro Pro Met Gln Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Ala 
865                 870                 875                 880 


Val Ala Ile Phe Tyr Pro Gly Val Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Val Leu Gly Pro Ala Tyr Leu Leu Lys Gly Ala Leu Thr Arg 
            900                 905                 910         


Val Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Met Cys Thr Met 
        915                 920                 925             


Ala Arg His Leu Ala Gly Gly Arg Tyr Val Gln Met Ala Leu Leu Ala 
    930                 935                 940                 


Leu Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Thr Pro Met 
945                 950                 955                 960 


Ser Asp Trp Ala Ala Ser Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Ile Ile Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Ala Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Ser Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Thr Ile Val Val Ser  Met Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Thr Glu Gln Ala  Gly Glu Ile Gln Val  Leu Ser Thr 
    1055                 1060                 1065             


Val Thr  Gln Ser Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Ser Arg 
    1085                 1090                 1095             


Gly Leu  Val Thr Gln Met Tyr  Ser Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Glu  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Ala Arg Arg Arg Gly  Asp Lys Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Arg Gly His Ala  Val Gly Val Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ser  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Thr Leu  Asp Ile Val Thr Arg  Ser Pro Thr Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Val Ala Tyr 
    1235                 1240                 1245             


Ala Ala  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Leu Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Ala 
    1280                 1285                 1290             


Pro Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Gly Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Val  Asp Ser Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Thr Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Thr Pro His Pro Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly Gln Glu Gly  Glu Ile Pro Phe Tyr  Gly Arg Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ser Tyr Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Leu Asn Ser Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Val  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Ile Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Thr Gly Glu  Arg Ala Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ser Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Ser Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Val 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ser Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Val Met  Thr Ser Thr Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Val Cys  Ile Ile Gly Arg Leu  His Ile Asn Gln Arg  Ala Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Val Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Arg Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Ile 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Ser Lys  Gln Ala Gln Asp Ile  Gln Pro Thr Val Gln  Ala Ser Trp 
    1745                 1750                 1755             


Pro Lys  Val Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ser Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Leu Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Ile  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Ser Met  Glu Asp Val Val Asn  Leu Leu Pro Gly Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Pro Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Thr His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Thr  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Leu Leu Gly 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Asn Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Ile Pro  Cys Gly Gly Ser Trp  Leu Arg Asp 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Thr  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Thr  Ser Lys Leu Phe Pro  Lys Met Pro Gly Leu  Pro Phe Val 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Ile 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly Asn Val 
    2030                 2035                 2040             


Arg Leu  Gly Ser Met Arg Ile  Thr Gly Pro Lys Thr  Cys Met Asn 
    2045                 2050                 2055             


Ile Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Gln 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Ala Pro  Asn Phe Lys Val Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Ala  Glu Val Thr Gln His  Gly Ser Tyr 
    2090                 2095                 2100             


His Tyr  Ile Thr Gly Leu Thr  Thr Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Leu  Pro Ser Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Thr  Pro Lys Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Ser  Phe Cys Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Asp Val Leu  Met Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Glu Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Arg Ala Thr Cys Thr  Thr His Gly 
    2210                 2215                 2220             


Lys Ala  Tyr Asp Val Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Gly Ser Lys Val  Val Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Pro Met Val  Glu Glu Arg Ser Asp  Leu Glu Pro 
    2255                 2260                 2265             


Ser Ile  Pro Ser Glu Tyr Met  Leu Pro Lys Lys Arg  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ala Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Ser  Trp Lys Arg Pro Asp  Tyr Gln Pro Ala Thr  Val Ala Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Pro Arg  Lys Thr Pro Thr Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Thr Val Gly Leu  Ser Glu Asp Ser Ile  Gly Asp Ala 
    2330                 2335                 2340             


Leu Gln  Gln Leu Ala Ile Lys  Ser Phe Gly Gln Pro  Pro Pro Ser 
    2345                 2350                 2355             


Gly Asp  Ser Gly Leu Ser Thr  Gly Ala Gly Ala Ala  Asp Ser Gly 
    2360                 2365                 2370             


Ser Gln  Thr Pro Pro Asp Glu  Leu Ala Leu Ser Glu  Thr Gly Ser 
    2375                 2380                 2385             


Ile Ser  Ser Met Pro Pro Leu  Glu Gly Glu Leu Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Pro Glu Gln Val Glu  Pro Gln Pro Pro Pro  Gln Gly Gly 
    2405                 2410                 2415             


Val Ala  Ala Pro Gly Ser Asp  Ser Gly Ser Trp Ser  Thr Cys Ser 
    2420                 2425                 2430             


Glu Glu  Asp Asp Ser Val Val  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Ser Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Leu Arg Tyr  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Cys Thr Thr Thr Lys  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Met Gln  Val Leu Asp Ser Tyr  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Lys Asp Ile Lys Leu  Ala Ala Ser Lys Val  Thr Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Met Glu Glu Ala  Cys Gln Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Arg  Ser Lys Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Gly  Arg Ala Val Asn His  Ile Lys Ser Val Trp  Lys Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Ser Glu Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Val Asp  Pro Thr Lys Gly Gly  Lys Lys Ala 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Thr Gln Lys Leu Pro  Gln Ala Val 
    2615                 2620                 2625             


Met Gly  Ala Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Gln Arg Val 
    2630                 2635                 2640             


Glu Phe  Leu Leu Lys Ala Trp  Ala Glu Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Arg Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Glu Glu  Ala His Thr Ala Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Phe Asn  Ser Lys Gly Gln Thr  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Ile  Thr Cys Tyr Val Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Ile Ala Pro Thr Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Thr Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Pro  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Gly Pro Gln Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Ala  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Ala Arg Met  Val Leu Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Met Ala Gln Asp Thr  Leu Asp Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Ser Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Asp Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Thr  Pro His Glu Leu Thr  Arg Val Ala 
    2915                 2920                 2925             


Ser Ala  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ser  Arg Gly Gly 
    2945                 2950                 2955             


Arg Ala  Ala Val Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Arg  Leu Leu Asp 
    2975                 2980                 2985             


Leu Ser  Ser Trp Phe Thr Val  Gly Ala Gly Gly Gly  Gly Ile Tyr 
    2990                 2995                 3000             


His Ser  Val Ser Arg Ala Arg  Pro Arg Leu Leu Leu  Phe Gly Leu 
    3005                 3010                 3015             


Leu Leu  Leu Phe Val Gly Val  Gly Leu Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  104
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  104

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala 
            180                 185                 190         


Glu Val Lys Asn Ile Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Thr 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Val Gly Asn Ala Ser Gln Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Arg 
    370                 375                 380                 


Thr His Thr Val Gly Gly Ser Ala Ala Gln Thr Thr Gly Arg Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Asp Met Gly Pro Arg Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr His Ser Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ser Ala Cys Arg Ser Ile Glu Ala 
    450                 455                 460                 


Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Gln Cys 
                485                 490                 495     


Gly Val Val Ser Ala Lys Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Leu Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Ser 
545                 550                 555                 560 


Gly Tyr Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Phe Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Val Ile Leu His Ala Ala Ser Ala Ala Ser Cys Asn Gly 
        755                 760                 765             


Phe Leu Tyr Phe Val Ile Phe Ser Val Ala Ala Trp Tyr Ile Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Ala Thr Tyr Ser Leu Thr Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Ser Leu Leu Leu Leu Ala Leu Pro Gln Gln Ala Tyr Ala Tyr Asp Ala 
                805                 810                 815     


Ser Val His Gly Gln Ile Gly Ala Ala Leu Leu Val Met Ile Thr Leu 
            820                 825                 830         


Phe Thr Leu Thr Pro Gly Tyr Lys Thr Leu Leu Ser Arg Phe Leu Trp 
        835                 840                 845             


Trp Leu Cys Tyr Leu Leu Thr Leu Gly Glu Ala Met Val Gln Glu Trp 
    850                 855                 860                 


Ala Pro Pro Met Gln Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Ala 
865                 870                 875                 880 


Val Ala Ile Phe Tyr Pro Gly Val Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Val Leu Gly Pro Ala Tyr Leu Leu Lys Gly Ala Leu Thr Arg 
            900                 905                 910         


Val Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Met Cys Thr Met 
        915                 920                 925             


Ala Arg His Leu Ala Gly Gly Arg Tyr Val Gln Met Ala Leu Leu Ala 
    930                 935                 940                 


Leu Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Thr Pro Met 
945                 950                 955                 960 


Ser Asp Trp Ala Ala Ser Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Ile Ile Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Ala Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Ser Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Thr Ile Val Val Ser  Met Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Thr Glu Gln Ala  Gly Glu Ile Gln Val  Leu Ser Thr 
    1055                 1060                 1065             


Val Thr  Gln Ser Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Ser Arg 
    1085                 1090                 1095             


Gly Leu  Val Thr Gln Met Tyr  Ser Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Glu  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Ala Arg Arg Arg Gly  Asp Lys Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Arg Gly His Ala  Val Gly Val Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ser  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Thr Leu  Asp Ile Val Thr Arg  Ser Pro Thr Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Val Ala Tyr 
    1235                 1240                 1245             


Ala Ala  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Leu Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Ala 
    1280                 1285                 1290             


Pro Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Gly Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Val  Asp Ser Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Thr Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Thr Pro His Pro Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly Gln Glu Gly  Glu Ile Pro Phe Tyr  Gly Arg Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ser Tyr Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Leu Asn Ser Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Val  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Ile Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Thr Gly Glu  Arg Ala Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ser Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Ser Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Val 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ser Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Val Met  Thr Ser Thr Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Val Cys  Ile Ile Gly Arg Leu  His Ile Asn Gln Arg  Ala Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Val Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Arg Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Ile 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Ser Lys  Gln Ala Gln Asp Ile  Gln Pro Thr Val Gln  Ala Ser Trp 
    1745                 1750                 1755             


Pro Lys  Val Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ser Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Leu Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Ile  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Ser Met  Glu Asp Val Val Asn  Leu Leu Pro Gly Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Pro Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Ser His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Thr  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Leu Leu Gly 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Asn Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Ile Pro  Cys Gly Gly Ser Trp  Leu Arg Asp 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Thr  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Thr  Ser Lys Leu Phe Pro  Lys Met Pro Gly Leu  Pro Phe Val 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Ile 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly Asn Val 
    2030                 2035                 2040             


Arg Leu  Gly Ser Met Arg Ile  Thr Gly Pro Lys Thr  Cys Met Asn 
    2045                 2050                 2055             


Ile Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Gln 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Ala Pro  Asn Phe Lys Val Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Ala  Glu Val Thr Gln His  Gly Ser Tyr 
    2090                 2095                 2100             


His Tyr  Ile Thr Gly Leu Thr  Thr Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Leu  Pro Ser Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Thr  Pro Lys Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Ser  Phe Cys Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Asp Val Leu  Met Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Glu Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Arg Ala Thr Cys Thr  Thr His Gly 
    2210                 2215                 2220             


Lys Ala  Tyr Asp Val Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Gly Ser Lys Val  Val Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Pro Met Val  Glu Glu Arg Ser Asp  Leu Glu Pro 
    2255                 2260                 2265             


Ser Ile  Pro Ser Glu Tyr Met  Leu Pro Lys Lys Arg  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ala Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Ser  Trp Lys Arg Pro Asp  Tyr Gln Pro Ala Thr  Val Ala Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Pro Arg  Lys Thr Pro Thr Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Thr Val Gly Leu  Ser Glu Asp Ser Ile  Gly Asp Ala 
    2330                 2335                 2340             


Leu Gln  Gln Leu Ala Ile Lys  Ser Phe Gly Gln Pro  Pro Pro Ser 
    2345                 2350                 2355             


Gly Asp  Ser Gly Leu Ser Thr  Gly Ala Gly Ala Ala  Asp Ser Gly 
    2360                 2365                 2370             


Ser Gln  Thr Pro Pro Asp Glu  Leu Ala Leu Ser Glu  Thr Gly Ser 
    2375                 2380                 2385             


Ile Ser  Ser Met Pro Pro Leu  Glu Gly Glu Leu Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Pro Glu Gln Val Glu  Pro Gln Pro Pro Pro  Gln Gly Gly 
    2405                 2410                 2415             


Val Ala  Ala Pro Gly Ser Asp  Ser Gly Ser Trp Ser  Thr Cys Ser 
    2420                 2425                 2430             


Glu Glu  Asp Asp Ser Val Val  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Ser Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Leu Arg Tyr  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Cys Thr Thr Thr Lys  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Met Gln  Val Leu Asp Ser Tyr  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Lys Asp Ile Lys Leu  Ala Ala Ser Lys Val  Thr Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Met Glu Glu Ala  Cys Gln Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Arg  Ser Lys Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Gly  Arg Ala Val Asn His  Ile Lys Ser Val Trp  Lys Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Ser Glu Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Val Asp  Pro Thr Lys Gly Gly  Lys Lys Ala 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Thr Gln Lys Leu Pro  Gln Ala Val 
    2615                 2620                 2625             


Met Gly  Ala Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Gln Arg Val 
    2630                 2635                 2640             


Glu Phe  Leu Leu Lys Ala Trp  Ala Glu Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Arg Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Glu Glu  Ala His Thr Ala Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Phe Asn  Ser Lys Gly Gln Thr  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Ile  Thr Cys Tyr Val Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Ile Ala Pro Thr Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Thr Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Pro  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Gly Pro Gln Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Ala  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Ala Arg Met  Val Leu Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Met Ala Gln Asp Thr  Leu Asp Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Ser Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Asp Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Thr  Pro His Glu Leu Thr  Arg Val Ala 
    2915                 2920                 2925             


Ser Ala  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ser  Arg Gly Gly 
    2945                 2950                 2955             


Arg Ala  Ala Val Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Arg  Leu Leu Asp 
    2975                 2980                 2985             


Leu Ser  Ser Trp Phe Thr Val  Gly Ala Gly Gly Gly  Gly Ile Tyr 
    2990                 2995                 3000             


His Ser  Val Ser Arg Ala Arg  Pro Arg Leu Leu Leu  Phe Gly Leu 
    3005                 3010                 3015             


Leu Leu  Leu Phe Val Gly Val  Gly Leu Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  105
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  105

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr Pro Val Ser Ala Ala 
            180                 185                 190         


Glu Val Lys Asn Ile Ser Thr Gly Tyr Met Val Thr Asn Asp Cys Thr 
        195                 200                 205             


Asn Asp Ser Ile Thr Trp Gln Leu Gln Ala Ala Val Leu His Val Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Lys Val Gly Asn Ala Ser Gln Cys Trp Ile 
225                 230                 235                 240 


Pro Val Ser Pro Asn Val Ala Val Gln Arg Pro Gly Ala Leu Thr Gln 
                245                 250                 255     


Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala Ala 
        275                 280                 285             


Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Thr Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Met Arg Val Pro Glu Val Ile Ile Asp Ile Ile Ser Gly Ala His 
            340                 345                 350         


Trp Gly Val Met Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Arg 
    370                 375                 380                 


Thr His Thr Val Gly Gly Ser Ala Ala Gln Thr Thr Gly Arg Leu Thr 
385                 390                 395                 400 


Ser Leu Phe Asp Met Gly Pro Arg Gln Lys Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu His Thr Gly Phe Ile Ala Ser Leu Phe Tyr Thr His Ser Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Met Ser Ala Cys Arg Ser Ile Glu Ala 
    450                 455                 460                 


Phe Arg Val Gly Trp Gly Ala Leu Gln Tyr Glu Asp Asn Val Thr Asn 
465                 470                 475                 480 


Pro Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Gln Cys 
                485                 490                 495     


Gly Val Val Ser Ala Lys Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Ala Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Leu Gly Ser Trp Phe Gly Cys Thr Trp Met Asn Ser Ser 
545                 550                 555                 560 


Gly Tyr Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Thr Arg Ala Asp 
                565                 570                 575     


Phe Asn Ala Ser Thr Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Thr Thr Tyr Leu Lys Cys Gly Ser Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Ile Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Leu Thr Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Asn Leu Glu Asp Arg Asp Arg Ser Gln Leu Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Ile Leu Pro Cys Ser Tyr Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Phe Met Tyr Gly Leu Ser Pro Ala Leu Thr Lys Tyr Ile Val Arg Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Leu Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Val Ile Leu His Ala Ala Ser Ala Ala Ser Cys Asn Gly 
        755                 760                 765             


Phe Leu Tyr Phe Val Ile Phe Ser Val Ala Ala Trp Tyr Ile Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Leu Ala Thr Tyr Ser Leu Thr Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Ser Leu Leu Leu Leu Ala Leu Pro Gln Gln Ala Tyr Ala Tyr Asp Ala 
                805                 810                 815     


Ser Val His Gly Gln Ile Gly Ala Ala Leu Leu Val Met Ile Thr Leu 
            820                 825                 830         


Phe Thr Leu Thr Pro Gly Tyr Lys Thr Leu Leu Ser Arg Phe Leu Trp 
        835                 840                 845             


Trp Leu Cys Tyr Leu Leu Thr Leu Gly Glu Ala Met Val Gln Glu Trp 
    850                 855                 860                 


Ala Pro Pro Met Gln Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Ala 
865                 870                 875                 880 


Val Ala Ile Phe Tyr Pro Gly Val Val Phe Asp Ile Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Val Leu Gly Pro Ala Tyr Leu Leu Lys Gly Ala Leu Thr Arg 
            900                 905                 910         


Val Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Met Cys Thr Met 
        915                 920                 925             


Ala Arg His Leu Ala Gly Gly Arg Tyr Val Gln Met Ala Leu Leu Ala 
    930                 935                 940                 


Leu Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Thr Pro Met 
945                 950                 955                 960 


Ser Asp Trp Ala Ala Ser Gly Leu Arg Asp Leu Ala Val Ala Val Glu 
                965                 970                 975     


Pro Ile Ile Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Ala Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Ser Leu Leu  Ala Pro Ile Thr Ala  Tyr Ala Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Thr Ile Val Val Ser  Met Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Thr Glu Gln Ala  Gly Glu Ile Gln Val  Leu Ser Thr 
    1055                 1060                 1065             


Val Thr  Gln Ser Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Ser Arg 
    1085                 1090                 1095             


Gly Leu  Val Thr Gln Met Tyr  Ser Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Glu  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Ala Arg Arg Arg Gly  Asp Lys Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Pro Arg Gly His Ala  Val Gly Val Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ser  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Thr Leu  Asp Ile Val Thr Arg  Ser Pro Thr Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Thr Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Val Ala Tyr 
    1235                 1240                 1245             


Ala Ala  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Leu Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Ala 
    1280                 1285                 1290             


Pro Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Leu Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Gly Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ala Val  Asp Ser Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Thr Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Ser Val Thr  Thr Pro His Pro Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly Gln Glu Gly  Glu Ile Pro Phe Tyr  Gly Arg Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ser Tyr Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Leu Asn Ser Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Thr Gln Val  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Ile Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Thr Gly Glu  Arg Ala Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ser Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Ser Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Val 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ser Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Val Met  Thr Ser Thr Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Val Cys  Ile Ile Gly Arg Leu  His Ile Asn Gln Arg  Ala Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Val Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Arg Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Ile 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Ser Lys  Gln Ala Gln Asp Ile  Gln Pro Thr Val Gln  Ala Ser Trp 
    1745                 1750                 1755             


Pro Lys  Val Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Ser Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Leu Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Val Leu Val Asp Ile  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Ser Met  Glu Asp Val Val Asn  Leu Leu Pro Gly Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Pro Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Thr His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Thr  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Leu Leu Gly 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Asn Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Ile Pro  Cys Gly Gly Ser Trp  Leu Arg Asp 
    1970                 1975                 1980             


Val Trp  Asp Trp Val Cys Thr  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Thr  Ser Lys Leu Phe Pro  Lys Met Pro Gly Leu  Pro Phe Val 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Ile 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly Asn Val 
    2030                 2035                 2040             


Arg Leu  Gly Ser Met Arg Ile  Thr Gly Pro Lys Thr  Cys Met Asn 
    2045                 2050                 2055             


Ile Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Gln 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Ala Pro  Asn Phe Lys Val Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Ala  Glu Val Thr Gln His  Gly Ser Tyr 
    2090                 2095                 2100             


His Tyr  Ile Thr Gly Leu Thr  Thr Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Leu  Pro Ser Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Thr  Pro Lys Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Ser  Phe Cys Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Asp Val Leu  Met Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Thr Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Glu Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Arg Ala Thr Cys Thr  Thr His Gly 
    2210                 2215                 2220             


Lys Ala  Tyr Asp Val Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Gly Ser Lys Val  Val Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Pro Met Val  Glu Glu Arg Ser Asp  Leu Glu Pro 
    2255                 2260                 2265             


Ser Ile  Pro Ser Glu Tyr Met  Leu Pro Lys Lys Arg  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ala Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Ser  Trp Lys Arg Pro Asp  Tyr Gln Pro Ala Thr  Val Ala Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Pro Arg  Lys Thr Pro Thr Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Thr Val Gly Leu  Ser Glu Asp Ser Ile  Gly Asp Ala 
    2330                 2335                 2340             


Leu Gln  Gln Leu Ala Ile Lys  Ser Phe Gly Gln Pro  Pro Pro Ser 
    2345                 2350                 2355             


Gly Asp  Ser Gly Leu Ser Thr  Gly Ala Gly Ala Ala  Asp Ser Gly 
    2360                 2365                 2370             


Ser Gln  Thr Pro Pro Asp Glu  Leu Ala Leu Ser Glu  Thr Gly Ser 
    2375                 2380                 2385             


Ile Ser  Ser Met Pro Pro Leu  Glu Gly Glu Leu Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Pro Glu Gln Val Glu  Pro Gln Pro Pro Pro  Gln Gly Gly 
    2405                 2410                 2415             


Val Ala  Ala Pro Gly Ser Asp  Ser Gly Ser Trp Ser  Thr Cys Ser 
    2420                 2425                 2430             


Glu Glu  Asp Asp Ser Val Val  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Ser Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Leu Arg Tyr  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Cys Thr Thr Thr Lys  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Met Gln  Val Leu Asp Ser Tyr  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Lys Asp Ile Lys Leu  Ala Ala Ser Lys Val  Thr Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Met Glu Glu Ala  Cys Gln Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Arg  Ser Lys Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Gly  Arg Ala Val Asn His  Ile Lys Ser Val Trp  Lys Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Ser Glu Thr Pro  Ile Pro Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Val Asp  Pro Thr Lys Gly Gly  Lys Lys Ala 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Thr Gln Lys Leu Pro  Gln Ala Val 
    2615                 2620                 2625             


Met Gly  Ala Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Gln Arg Val 
    2630                 2635                 2640             


Glu Phe  Leu Leu Lys Ala Trp  Ala Glu Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Arg Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Glu Glu  Ala His Thr Ala Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Phe Asn  Ser Lys Gly Gln Thr  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Leu Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Ile  Thr Cys Tyr Val Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Ile Ala Pro Thr Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Thr Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Pro  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Gly Pro Gln Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Tyr  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Ala  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Ala Arg Met  Val Leu Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Met Ala Gln Asp Thr  Leu Asp Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Ser Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Asp Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Thr  Pro His Glu Leu Thr  Arg Val Ala 
    2915                 2920                 2925             


Ser Ala  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ser  Arg Gly Gly 
    2945                 2950                 2955             


Arg Ala  Ala Val Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Arg  Leu Leu Asp 
    2975                 2980                 2985             


Leu Ser  Ser Trp Phe Thr Val  Gly Ala Gly Gly Gly  Gly Ile Tyr 
    2990                 2995                 3000             


His Ser  Val Ser Arg Ala Arg  Pro Arg Leu Leu Leu  Phe Gly Leu 
    3005                 3010                 3015             


Leu Leu  Leu Phe Val Gly Val  Gly Leu Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  106
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  106

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Arg Val Ile Asp Thr Ile Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Val Thr Val Pro Val Ser Ala Val 
            180                 185                 190         


Glu Val Arg Asn Ile Ser Ser Ser Tyr Tyr Ala Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Asn Ser Ile Thr Trp Gln Leu Thr Asp Ala Val Leu His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Asn Asp Asn Gly Thr Leu His Cys Trp Ile 
225                 230                 235                 240 


Gln Val Thr Pro Asn Val Ala Val Lys His Arg Gly Ala Leu Thr Arg 
                245                 250                 255     


Ser Leu Arg Thr His Val Asp Met Ile Val Met Ala Ala Thr Ala Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Val Cys Gly Ala Val Met Ile Leu Ser 
        275                 280                 285             


Gln Ala Phe Met Val Ser Pro Gln Arg His Asn Phe Thr Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Gln Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Leu Asn Trp Ser Pro Thr Leu Ala Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Ala Arg Val Pro Glu Met Val Leu Glu Ile Ile Phe Gly Gly His 
            340                 345                 350         


Trp Gly Val Val Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Ile Ala Ile Leu Leu Leu Val Ala Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr Tyr Ser Ser Gly Gln Glu Ala Gly Arg Thr Val Leu Gly Phe Thr 
385                 390                 395                 400 


Asn Leu Phe Thr Ser Gly Ala Lys Gln Asn Leu Tyr Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Met Ala Ser Leu Phe Tyr Thr His Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ser Ser Cys Arg Gly Leu Asp Asp 
    450                 455                 460                 


Phe Arg Ile Gly Trp Gly Thr Leu Glu Tyr Glu Thr His Val Thr Asn 
465                 470                 475                 480 


Asp Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys 
                485                 490                 495     


Gly Ile Val Pro Ala Arg Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Lys Gln Gly Val Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Arg Gly Ala Trp Phe Gly Cys Thr Trp Met Asn Gly Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Lys Asp 
                565                 570                 575     


Tyr Asn Ser Thr Ile Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Ala Thr Tyr Leu Lys Cys Gly Ala Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile Phe Lys Ala Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Phe Ser Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Arg Leu Glu Asp Arg Asp Arg Gly Gln Gln Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Val Leu Pro Cys Ser Phe Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Leu Thr Arg Tyr Ile Val Lys Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Ile Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Ile Ile Leu His Ser Ala Ser Ala Ala Ser Ala Asn Gly 
        755                 760                 765             


Pro Leu Trp Phe Phe Ile Phe Phe Thr Ala Ala Trp Tyr Leu Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Val Ala Thr Tyr Ser Val Leu Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Leu Leu Leu Val Leu Ala Leu Pro Gln Gln Ala Tyr Ala Leu Asp Ala 
                805                 810                 815     


Ala Glu Gln Gly Glu Leu Gly Leu Ala Ile Leu Val Ile Ile Ser Ile 
            820                 825                 830         


Phe Thr Leu Thr Pro Ala Tyr Lys Ile Leu Leu Ser Arg Ser Val Trp 
        835                 840                 845             


Trp Leu Ser Tyr Met Leu Val Leu Ala Glu Ala Gln Ile Gln Gln Trp 
    850                 855                 860                 


Val Pro Pro Leu Glu Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Val 
865                 870                 875                 880 


Ala Val Ile Leu His Pro Arg Leu Val Phe Glu Val Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Ile Leu Gly Pro Ala Tyr Leu Leu Lys Ala Ser Leu Leu Arg 
            900                 905                 910         


Ile Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Val Cys Thr Leu 
        915                 920                 925             


Val Lys His Leu Ala Gly Ala Arg Tyr Ile Gln Met Leu Leu Ile Thr 
    930                 935                 940                 


Ile Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Ser Pro Leu 
945                 950                 955                 960 


Ser Thr Trp Ala Ala Gln Gly Leu Arg Asp Leu Ala Ile Ala Val Glu 
                965                 970                 975     


Pro Val Val Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Val Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Lys Leu Leu  Ala Pro Ile Thr Ala  Tyr Thr Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Ala Ile Val Val Ser  Leu Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Asn Glu Gln Ala  Gly Gln Val Gln Val  Leu Ser Ser 
    1055                 1060                 1065             


Val Thr  Gln Thr Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Pro Lys 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Thr Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Asp  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Val Arg Arg Lys Asp  Asp Arg Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Ser Arg Gly His Ala  Val Gly Leu Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ala  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Ser Leu  Asp Val Ala Thr Arg  Thr Pro Ser Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Ser Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Ala Ala Tyr 
    1235                 1240                 1245             


Ala Ser  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Met Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Asp 
    1280                 1285                 1290             


Ser Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Ile Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Ala Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ser Val  Asp Ala Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Val Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Thr Val Thr  Thr Pro His Ser Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly His Glu Gly  Glu Ile Pro Phe Tyr  Gly Lys Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ala Phe Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Val Asn Ala Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Ser Gln Ile  Val Asp Phe Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Val Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Ser Gly Glu  Arg Pro Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ala Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Gly Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Thr 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ala Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Ile Met  Thr Ser Ser Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ala Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Ile Ser  Ile Ile Gly Arg Leu  His Leu Asn Asp Arg  Val Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Ile Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Lys Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Met 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Thr Arg  Gln Ala Gln Asp Ile  Gln Pro Ala Ile Gln  Ser Ser Trp 
    1745                 1750                 1755             


Pro Lys  Leu Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Pro Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Met Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Ile Leu Val Asp Val  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Thr Val  Glu Asp Val Val Asn  Leu Leu Pro Ala Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Gln Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Val  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Val Leu Ser 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Ala Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Val Pro  Cys Ser Gly Ser Trp  Leu Gln Asp 
    1970                 1975                 1980             


Ile Trp  Asp Trp Val Cys Ser  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Ser  Ser Lys Leu Leu Pro  Lys Met Pro Gly Ile  Pro Phe Ile 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Val 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly His Val 
    2030                 2035                 2040             


Arg Met  Gly Thr Met Lys Ile  Thr Gly Pro Lys Thr  Cys Leu Asn 
    2045                 2050                 2055             


Leu Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Pro 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Pro Pro  Asn Tyr Lys Thr Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Val  Glu Val Thr Gln His  Gly Ser Phe 
    2090                 2095                 2100             


Ser Tyr  Val Thr Gly Leu Thr  Ser Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Val  Pro Ala Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Val  Pro Gly Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Thr  Phe Thr Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Glu Val Leu  Ala Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Ala Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Gln Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Lys Ala Thr Cys Thr  Thr His Lys 
    2210                 2215                 2220             


Thr Ala  Tyr Asp Cys Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Asp Ser Lys Val  Ile Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Ser Met Thr  Glu Val Glu Asp Asp  Arg Glu Pro 
    2255                 2260                 2265             


Ser Val  Pro Ser Glu Tyr Leu  Ile Lys Arg Arg Lys  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Pro Trp Ala Arg  Pro Asp Tyr Asn Pro  Val Leu Ile 
    2285                 2290                 2295             


Glu Thr  Trp Lys Arg Pro Gly  Tyr Glu Pro Pro Thr  Val Leu Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Thr Pro  Gln Thr Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Ala Lys Val Leu  Thr Gln Asp Asn Val  Glu Gly Ile 
    2330                 2335                 2340             


Leu Arg  Glu Met Ala Asp Lys  Val Leu Ser Pro Leu  Gln Asp Asn 
    2345                 2350                 2355             


Asn Asp  Ser Gly His Ser Thr  Gly Ala Asp Thr Gly  Gly Asp Ile 
    2360                 2365                 2370             


Val Gln  Gln Pro Ser Asp Glu  Thr Ala Ala Ser Glu  Ala Gly Ser 
    2375                 2380                 2385             


Leu Ser  Ser Met Pro Pro Leu  Glu Gly Glu Pro Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Phe Glu Pro Val Gly  Ser Ala Pro Pro Ser  Glu Gly Glu 
    2405                 2410                 2415             


Cys Glu  Val Ile Asp Ser Asp  Ser Lys Ser Trp Ser  Thr Val Ser 
    2420                 2425                 2430             


Asp Gln  Glu Asp Ser Val Ile  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Gly Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Met Arg Phe  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Ser Thr Thr Ser Arg  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Val Gln  Val Leu Asp Ala His  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Gln Asp Val Lys Arg  Ala Ala Ser Lys Val  Ser Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Val Glu Glu Ala  Cys Ala Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Lys  Ser Arg Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Arg  Arg Ala Val Asn His  Ile Arg Ser Val Trp  Glu Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Gln His Thr Pro  Ile Asp Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Ile Asp  Pro Thr Lys Gly Gly  Lys Lys Pro 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Ala Gln Lys Leu Pro  Lys Ala Ile 
    2615                 2620                 2625             


Met Gly  Pro Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Glu Arg Val 
    2630                 2635                 2640             


Asp Phe  Leu Leu Lys Ala Trp  Gly Ser Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Gln Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Gln Glu  Ala Arg Thr Val Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Thr Asn  Ser Lys Gly Gln Ser  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Phe Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Met  Thr Cys Tyr Ile Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Val Asp Pro Val Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Asn Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Leu  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Asp Ser Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Phe  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Thr  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Ile Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Leu Ala Gln Asp Thr  Leu Asn Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Asn Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Glu Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Ser  Pro His Glu Leu Ser  Arg Val Ala 
    2915                 2920                 2925             


Ala Thr  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ala  Gln Gly Ala 
    2945                 2950                 2955             


Arg Ala  Ala Ile Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Ser  Arg Leu Asp 
    2975                 2980                 2985             


Leu Ser  Gly Trp Phe Thr Val  Gly Ala Gly Gly Gly  Asp Ile Tyr 
    2990                 2995                 3000             


His Ser  Val Ser His Ala Arg  Pro Arg Leu Leu Leu  Leu Cys Leu 
    3005                 3010                 3015             


Leu Leu  Leu Ser Val Gly Val  Gly Ile Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  107
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  107

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Arg Val Ile Asp Thr Ile Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Val Thr Val Pro Val Ser Ala Val 
            180                 185                 190         


Glu Val Arg Asn Ile Ser Ser Ser Tyr Tyr Ala Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Asn Ser Ile Thr Trp Gln Leu Thr Asp Ala Val Leu His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Asn Asp Asn Gly Thr Leu His Cys Trp Ile 
225                 230                 235                 240 


Gln Val Thr Pro Asn Val Ala Val Lys His Arg Gly Ala Leu Thr Arg 
                245                 250                 255     


Ser Leu Arg Thr His Val Asp Met Ile Val Met Ala Ala Thr Ala Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Val Cys Gly Ala Val Met Ile Leu Ser 
        275                 280                 285             


Gln Ala Phe Met Val Ser Pro Gln Arg His Asn Phe Thr Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Gln Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Leu Asn Trp Ser Pro Thr Leu Ala Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Ala Arg Val Pro Glu Met Val Leu Glu Ile Ile Phe Gly Gly His 
            340                 345                 350         


Trp Gly Val Val Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Ile Ala Ile Leu Leu Leu Val Ala Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr Tyr Ser Ser Gly Gln Glu Ala Gly Arg Thr Val Leu Gly Phe Thr 
385                 390                 395                 400 


Asn Leu Phe Thr Ser Gly Ala Lys Gln Asn Leu Tyr Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Met Ala Ser Leu Phe Tyr Thr His Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ser Ser Cys Arg Gly Leu Asp Asp 
    450                 455                 460                 


Phe Arg Ile Gly Trp Gly Thr Leu Glu Tyr Glu Thr His Val Thr Asn 
465                 470                 475                 480 


Asp Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys 
                485                 490                 495     


Gly Ile Val Pro Ala Arg Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Lys Gln Gly Val Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Arg Gly Ala Trp Phe Gly Cys Thr Trp Met Asn Gly Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Lys Asp 
                565                 570                 575     


Tyr Asn Ser Thr Ile Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Ala Thr Tyr Leu Lys Cys Gly Ala Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile Phe Lys Ala Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Phe Ser Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Arg Leu Glu Asp Arg Asp Arg Gly Gln Gln Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Val Leu Pro Cys Ser Phe Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Leu Thr Arg Tyr Ile Val Lys Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Ile Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Ile Ile Leu His Ser Ala Ser Ala Ala Ser Ala Asn Gly 
        755                 760                 765             


Pro Leu Trp Phe Phe Ile Phe Phe Thr Ala Ala Trp Tyr Leu Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Val Ala Thr Tyr Ser Val Leu Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Leu Leu Leu Val Leu Ala Leu Pro Gln Gln Ala Tyr Ala Leu Asp Ala 
                805                 810                 815     


Ala Glu Gln Gly Glu Leu Gly Leu Ala Ile Leu Val Ile Ile Ser Ile 
            820                 825                 830         


Phe Thr Leu Thr Pro Ala Tyr Lys Ile Leu Leu Ser Arg Ser Val Trp 
        835                 840                 845             


Trp Leu Ser Tyr Met Leu Val Leu Ala Glu Ala Gln Ile Gln Gln Trp 
    850                 855                 860                 


Val Pro Pro Leu Glu Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Val 
865                 870                 875                 880 


Ala Val Ile Leu His Pro Arg Leu Val Phe Glu Val Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Ile Leu Gly Pro Ala Tyr Leu Leu Lys Ala Ser Leu Leu Arg 
            900                 905                 910         


Ile Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Val Cys Thr Leu 
        915                 920                 925             


Val Lys His Leu Ala Gly Ala Arg Tyr Ile Gln Met Leu Leu Ile Thr 
    930                 935                 940                 


Ile Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Ser Pro Leu 
945                 950                 955                 960 


Ser Thr Trp Ala Ala Gln Gly Leu Arg Asp Leu Ala Ile Ala Val Glu 
                965                 970                 975     


Pro Val Val Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Val Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Lys Leu Leu  Ala Pro Ile Thr Ala  Tyr Thr Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Ala Ile Val Val Ser  Leu Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Asn Glu Gln Ala  Gly Gln Val Gln Val  Leu Ser Ser 
    1055                 1060                 1065             


Val Thr  Gln Thr Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Pro Lys 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Thr Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Asp  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Val Arg Arg Lys Asp  Asp Arg Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Ser Arg Gly His Ala  Val Gly Leu Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ala  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Ser Leu  Asp Val Ala Thr Arg  Thr Pro Ser Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Ser Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Ala Ala Tyr 
    1235                 1240                 1245             


Ala Ser  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Met Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Asp 
    1280                 1285                 1290             


Ser Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Ile Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Ala Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ser Val  Asp Ala Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Val Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Thr Val Thr  Thr Pro His Ser Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly His Glu Gly  Glu Ile Pro Phe Tyr  Gly Lys Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ala Phe Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Val Asn Ala Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Ser Gln Ile  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Val Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Ser Gly Glu  Arg Pro Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ala Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Gly Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Thr 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ala Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Ile Met  Thr Ser Ser Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Ile Ser  Ile Ile Gly Arg Leu  His Leu Asn Asp Arg  Val Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Ile Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Lys Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Met 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Thr Arg  Gln Ala Gln Asp Ile  Gln Pro Ala Ile Gln  Ser Ser Trp 
    1745                 1750                 1755             


Pro Lys  Leu Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Pro Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Met Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Ile Leu Val Asp Val  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Thr Val  Glu Asp Val Val Asn  Leu Leu Pro Ala Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Gln Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Val  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Val Leu Ser 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Ala Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Val Pro  Cys Ser Gly Ser Trp  Leu Gln Asp 
    1970                 1975                 1980             


Ile Trp  Asp Trp Val Cys Ser  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Ser  Ser Lys Leu Leu Pro  Lys Met Pro Gly Ile  Pro Phe Ile 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Val 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly His Val 
    2030                 2035                 2040             


Arg Met  Gly Thr Met Lys Ile  Thr Gly Pro Lys Thr  Cys Leu Asn 
    2045                 2050                 2055             


Leu Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Pro 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Pro Pro  Asn Tyr Lys Thr Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Val  Glu Val Thr Gln His  Gly Ser Phe 
    2090                 2095                 2100             


Ser Tyr  Val Thr Gly Leu Thr  Ser Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Val  Pro Ala Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Val  Pro Gly Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Thr  Phe Thr Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Glu Val Leu  Ala Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Ala Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Gln Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Lys Ala Thr Cys Thr  Thr His Lys 
    2210                 2215                 2220             


Thr Ala  Tyr Asp Cys Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Asp Ser Lys Val  Ile Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Ser Met Thr  Glu Val Glu Asp Asp  Arg Glu Pro 
    2255                 2260                 2265             


Ser Val  Pro Ser Glu Tyr Leu  Ile Lys Arg Arg Lys  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Pro Trp Ala Arg  Pro Asp Tyr Asn Pro  Val Leu Ile 
    2285                 2290                 2295             


Glu Thr  Trp Lys Arg Pro Gly  Tyr Glu Pro Pro Thr  Val Leu Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Thr Pro  Gln Thr Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Ala Lys Val Leu  Thr Gln Asp Asn Val  Glu Gly Ile 
    2330                 2335                 2340             


Leu Arg  Glu Met Ala Asp Lys  Val Leu Ser Pro Leu  Gln Asp Asn 
    2345                 2350                 2355             


Asn Asp  Ser Gly His Ser Thr  Gly Ala Asp Thr Gly  Gly Asp Ile 
    2360                 2365                 2370             


Val Gln  Gln Pro Ser Asp Glu  Thr Ala Ala Ser Glu  Ala Gly Ser 
    2375                 2380                 2385             


Leu Ser  Ser Met Pro Pro Leu  Glu Gly Glu Pro Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Phe Glu Pro Val Gly  Ser Ala Pro Pro Ser  Glu Gly Glu 
    2405                 2410                 2415             


Cys Glu  Val Ile Asp Ser Asp  Ser Lys Ser Trp Ser  Thr Val Ser 
    2420                 2425                 2430             


Asp Gln  Glu Asp Ser Val Ile  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Gly Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Met Arg Phe  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Ser Thr Thr Ser Arg  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Val Gln  Val Leu Asp Ala His  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Gln Asp Val Lys Arg  Ala Ala Ser Lys Val  Ser Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Val Glu Glu Ala  Cys Ala Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Lys  Ser Arg Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Arg  Arg Ala Val Asn His  Ile Arg Ser Val Trp  Glu Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Gln His Thr Pro  Ile Asp Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Ile Asp  Pro Thr Lys Gly Gly  Lys Lys Pro 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Ala Gln Lys Leu Pro  Lys Ala Ile 
    2615                 2620                 2625             


Met Gly  Pro Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Glu Arg Val 
    2630                 2635                 2640             


Asp Phe  Leu Leu Lys Ala Trp  Gly Ser Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Gln Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Gln Glu  Ala Arg Thr Val Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Thr Asn  Ser Lys Gly Gln Ser  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Phe Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Met  Thr Cys Tyr Ile Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Val Asp Pro Val Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Asn Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Leu  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Asp Ser Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Phe  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Thr  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Ile Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Leu Ala Gln Asp Thr  Leu Asn Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Asn Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Glu Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Ser  Pro His Glu Leu Ser  Arg Val Ala 
    2915                 2920                 2925             


Ala Thr  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ala  Gln Gly Ala 
    2945                 2950                 2955             


Arg Ala  Ala Ile Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Ser  Arg Leu Asp 
    2975                 2980                 2985             


Leu Ser  Gly Trp Phe Thr Val  Gly Ala Gly Gly Gly  Gly Ile Tyr 
    2990                 2995                 3000             


His Ser  Val Ser His Ala Arg  Pro Arg Leu Leu Leu  Leu Cys Leu 
    3005                 3010                 3015             


Leu Leu  Leu Ser Val Gly Val  Gly Ile Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  108
<211>  3066
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  108

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Arg Val Ile Asp Thr Ile Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Val Thr Val Pro Val Ser Ala Val 
            180                 185                 190         


Glu Val Arg Asn Ile Ser Ser Ser Tyr Tyr Ala Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Asn Ser Ile Thr Trp Gln Leu Thr Asp Ala Val Leu His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Asn Asp Asn Gly Thr Leu His Cys Trp Ile 
225                 230                 235                 240 


Gln Val Thr Pro Asn Val Ala Val Lys His Arg Gly Ala Leu Thr Arg 
                245                 250                 255     


Ser Leu Arg Thr His Val Asp Met Ile Val Met Ala Ala Thr Ala Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Val Cys Gly Ala Val Met Ile Leu Ser 
        275                 280                 285             


Gln Ala Phe Met Val Ser Pro Gln Arg His Asn Phe Thr Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Gln Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Leu Asn Trp Ser Pro Thr Leu Ala Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Ala Arg Val Pro Glu Met Val Leu Glu Ile Ile Phe Gly Gly His 
            340                 345                 350         


Trp Gly Val Val Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Ile Ala Ile Leu Leu Leu Val Ala Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr Tyr Ser Ser Gly Gln Glu Ala Gly Arg Thr Val Leu Gly Phe Thr 
385                 390                 395                 400 


Asn Leu Phe Thr Ser Gly Ala Lys Gln Asn Leu Tyr Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Met Ala Ser Leu Phe Tyr Thr His Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ser Ser Cys Arg Gly Leu Asp Asp 
    450                 455                 460                 


Phe Arg Ile Gly Trp Gly Thr Leu Glu Tyr Glu Thr His Val Thr Asn 
465                 470                 475                 480 


Asp Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys 
                485                 490                 495     


Gly Ile Val Pro Ala Arg Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Lys Gln Gly Val Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Arg Gly Ala Trp Phe Gly Cys Thr Trp Met Asn Gly Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Lys Asp 
                565                 570                 575     


Tyr Asn Ser Thr Ile Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Ala Thr Tyr Leu Lys Cys Gly Ala Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile Phe Lys Ala Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Phe Ser Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Arg Leu Glu Asp Arg Asp Arg Gly Gln Gln Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Val Leu Pro Cys Ser Phe Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Leu Thr Arg Tyr Ile Val Lys Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Ile Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Ile Ile Leu His Ser Ala Ser Ala Ala Ser Ala Asn Gly 
        755                 760                 765             


Pro Leu Trp Phe Phe Ile Phe Phe Thr Ala Ala Trp Tyr Leu Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Val Ala Thr Tyr Ser Val Leu Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Leu Leu Leu Val Leu Ala Leu Pro Gln Gln Ala Tyr Ala Leu Asp Ala 
                805                 810                 815     


Ala Glu Gln Gly Glu Leu Gly Leu Ala Ile Leu Val Ile Ile Ser Ile 
            820                 825                 830         


Phe Thr Leu Thr Pro Ala Tyr Lys Ile Leu Leu Ser Arg Ser Val Trp 
        835                 840                 845             


Trp Leu Ser Tyr Met Leu Val Leu Ala Glu Ala Gln Ile Gln Gln Trp 
    850                 855                 860                 


Val Pro Pro Leu Glu Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Val 
865                 870                 875                 880 


Ala Val Ile Leu His Pro Arg Leu Val Phe Glu Val Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Ile Leu Gly Pro Ala Tyr Leu Leu Lys Ala Ser Leu Leu Arg 
            900                 905                 910         


Ile Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Val Cys Thr Leu 
        915                 920                 925             


Val Lys His Leu Ala Gly Ala Arg Tyr Ile Gln Met Leu Leu Ile Thr 
    930                 935                 940                 


Ile Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Ser Pro Leu 
945                 950                 955                 960 


Ser Thr Trp Ala Ala Gln Gly Leu Arg Asp Leu Ala Ile Ala Val Glu 
                965                 970                 975     


Pro Val Val Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Val Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Lys Leu Leu  Ala Pro Ile Thr Ala  Tyr Thr Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Ala Ile Val Val Ser  Leu Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Asn Glu Gln Ala  Gly Gln Val Gln Val  Leu Ser Ser 
    1055                 1060                 1065             


Val Thr  Gln Thr Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Pro Lys 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Thr Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Asp  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Val Arg Arg Lys Asp  Asp Arg Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Ser Arg Gly His Ala  Val Gly Leu Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ala  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Ser Leu  Asp Val Ala Thr Arg  Thr Pro Ser Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Ser Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Ala Ala Tyr 
    1235                 1240                 1245             


Ala Ser  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Met Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Asp 
    1280                 1285                 1290             


Ser Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Ile Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Ala Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ser Val  Asp Ala Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Val Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Thr Val Thr  Thr Pro His Ser Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly His Glu Gly  Glu Ile Pro Phe Tyr  Gly Lys Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ala Phe Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Val Asn Ala Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Ser Gln Ile  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Val Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Ser Gly Glu  Arg Pro Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ala Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Gly Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Thr 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ala Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Ile Met  Thr Ser Ser Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Ile Ser  Ile Ile Gly Arg Leu  His Leu Asn Asp Arg  Val Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Ile Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Lys Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Met 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Thr Arg  Gln Ala Gln Asp Ile  Gln Pro Ala Ile Gln  Ser Ser Trp 
    1745                 1750                 1755             


Pro Lys  Leu Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Pro Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Met Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Ile Leu Val Asp Val  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Thr Val  Glu Asp Val Val Asn  Leu Leu Pro Ala Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Gln Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Val  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Val Leu Ser 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Ala Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Val Pro  Cys Ser Gly Ser Trp  Leu Gln Asp 
    1970                 1975                 1980             


Ile Trp  Asp Trp Val Cys Ser  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Ser  Ser Lys Leu Leu Pro  Lys Met Pro Gly Ile  Pro Phe Ile 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Val 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly His Val 
    2030                 2035                 2040             


Arg Met  Gly Thr Met Lys Ile  Thr Gly Pro Lys Thr  Cys Leu Asn 
    2045                 2050                 2055             


Leu Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Pro 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Pro Pro  Asn Tyr Lys Thr Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Val  Glu Val Thr Gln His  Gly Ser Phe 
    2090                 2095                 2100             


Ser Tyr  Val Thr Gly Leu Thr  Ser Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Val  Pro Ala Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Val  Pro Gly Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Thr  Phe Thr Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Glu Val Leu  Ala Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Ala Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Gln Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Lys Ala Thr Cys Thr  Thr His Lys 
    2210                 2215                 2220             


Thr Ala  Tyr Asp Cys Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Asp Ser Lys Val  Ile Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Ser Met Thr  Glu Val Glu Asp Asp  Arg Glu Pro 
    2255                 2260                 2265             


Ser Val  Pro Ser Glu Tyr Leu  Ile Lys Arg Arg Lys  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Pro Trp Ala Arg  Pro Asp Tyr Asn Pro  Val Leu Ile 
    2285                 2290                 2295             


Glu Thr  Trp Lys Arg Pro Gly  Tyr Glu Pro Pro Thr  Val Leu Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Thr Pro  Gln Thr Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Ala Lys Val Leu  Thr Gln Asp Asn Val  Glu Gly Ile 
    2330                 2335                 2340             


Leu Arg  Glu Met Ala Asp Lys  Val Leu Ser Pro Leu  Gln Asp Asn 
    2345                 2350                 2355             


Asn Asp  Ser Gly His Ser Thr  Gly Ala Asp Thr Gly  Gly Asp Ile 
    2360                 2365                 2370             


Val Gln  Gln Pro Ser Asp Glu  Thr Ala Ala Ser Glu  Ala Gly Ser 
    2375                 2380                 2385             


Leu Ser  Ser Met Pro Pro Leu  Glu Gly Glu Pro Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Phe Glu Pro Val Gly  Ser Ala Pro Pro Ser  Glu Gly Glu 
    2405                 2410                 2415             


Cys Glu  Val Ile Asp Ser Asp  Ser Lys Ser Trp Ser  Thr Val Ser 
    2420                 2425                 2430             


Asp Gln  Glu Asp Ser Val Ile  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Gly Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Met Arg Phe  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Ser Thr Thr Ser Arg  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Val Gln  Val Leu Asp Ala His  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Gln Asp Val Lys Arg  Ala Ala Ser Lys Val  Ser Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Val Glu Glu Ala  Cys Ala Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Lys  Ser Arg Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Arg  Arg Ala Val Asn His  Ile Arg Ser Val Trp  Glu Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Gln His Thr Pro  Ile Asp Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Ile Asp  Pro Thr Lys Gly Gly  Lys Lys Pro 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Ala Gln Lys Leu Pro  Lys Ala Ile 
    2615                 2620                 2625             


Met Gly  Pro Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Glu Arg Val 
    2630                 2635                 2640             


Asp Phe  Leu Leu Lys Ala Trp  Gly Ser Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Gln Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Gln Glu  Ala Arg Thr Val Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Thr Asn  Ser Lys Gly Gln Ser  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Phe Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Met  Thr Cys Tyr Ile Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Val Asp Pro Val Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Asn Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Leu  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Asp Ser Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Phe  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Thr  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Ile Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Leu Ala Gln Asp Thr  Leu Asn Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Asn Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Glu Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Ser  Pro His Glu Leu Ser  Arg Val Ala 
    2915                 2920                 2925             


Ala Thr  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ala  Gln Gly Ala 
    2945                 2950                 2955             


Arg Ala  Ala Ile Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Ser  Arg Leu Asp 
    2975                 2980                 2985             


Leu Ser  Gly Trp Phe Thr Val  Gly Ala Gly Gly Gly  Gly Ile Phe 
    2990                 2995                 3000             


His Ser  Val Ser His Ala Arg  Pro Arg Leu Leu Leu  Leu Cys Leu 
    3005                 3010                 3015             


Leu Leu  Leu Ser Val Gly Val  Gly Ile Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


Gly Ile  Phe His Ser Val Ser  His Ala Arg Pro Arg  Leu Leu Leu 
    3035                 3040                 3045             


Leu Cys  Leu Leu Leu Leu Ser  Val Gly Val Gly Ile  Phe Leu Leu 
    3050                 3055                 3060             


Pro Ala  Arg 
    3065     


<210>  109
<211>  3066
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  109

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Arg Val Ile Asp Thr Ile Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Val Thr Val Pro Val Ser Ala Val 
            180                 185                 190         


Glu Val Arg Asn Ile Ser Ser Ser Tyr Tyr Ala Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Asn Ser Ile Thr Trp Gln Leu Thr Asp Ala Val Leu His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Asn Asp Asn Gly Thr Leu His Cys Trp Ile 
225                 230                 235                 240 


Gln Val Thr Pro Asn Val Ala Val Lys His Arg Gly Ala Leu Thr Arg 
                245                 250                 255     


Ser Leu Arg Thr His Val Asp Met Ile Val Met Ala Ala Thr Ala Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Val Cys Gly Ala Val Met Ile Leu Ser 
        275                 280                 285             


Gln Ala Phe Met Val Ser Pro Gln Arg His Asn Phe Thr Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Gln Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Leu Asn Trp Ser Pro Thr Leu Ala Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Ala Arg Val Pro Glu Met Val Leu Glu Ile Ile Phe Gly Gly His 
            340                 345                 350         


Trp Gly Val Val Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Ile Ala Ile Leu Leu Leu Val Ala Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr Tyr Ser Ser Gly Gln Glu Ala Gly Arg Thr Val Leu Gly Phe Thr 
385                 390                 395                 400 


Asn Leu Phe Thr Ser Gly Ala Lys Gln Asn Leu Tyr Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Met Ala Ser Leu Phe Tyr Thr His Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ser Ser Cys Arg Gly Leu Asp Asp 
    450                 455                 460                 


Phe Arg Ile Gly Trp Gly Thr Leu Glu Tyr Glu Thr His Val Thr Asn 
465                 470                 475                 480 


Asp Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys 
                485                 490                 495     


Gly Ile Val Pro Ala Arg Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Lys Gln Gly Val Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Arg Gly Ala Trp Phe Gly Cys Thr Trp Met Asn Gly Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Lys Asp 
                565                 570                 575     


Tyr Asn Ser Thr Ile Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Ala Thr Tyr Leu Lys Cys Gly Ala Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile Phe Lys Ala Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Phe Ser Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Arg Leu Glu Asp Arg Asp Arg Gly Gln Gln Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Val Leu Pro Cys Ser Phe Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Leu Thr Arg Tyr Ile Val Lys Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Ile Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Ile Ile Leu His Ser Ala Ser Ala Ala Ser Ala Asn Gly 
        755                 760                 765             


Pro Leu Trp Phe Phe Ile Phe Phe Thr Ala Ala Trp Tyr Leu Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Val Ala Thr Tyr Ser Val Leu Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Leu Leu Leu Val Leu Ala Leu Pro Gln Gln Ala Tyr Ala Leu Asp Ala 
                805                 810                 815     


Ala Glu Gln Gly Glu Leu Gly Leu Ala Ile Leu Val Ile Ile Ser Ile 
            820                 825                 830         


Phe Thr Leu Thr Pro Ala Tyr Lys Ile Leu Leu Ser Arg Ser Val Trp 
        835                 840                 845             


Trp Leu Ser Tyr Met Leu Val Leu Ala Glu Ala Gln Ile Gln Gln Trp 
    850                 855                 860                 


Val Pro Pro Leu Glu Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Val 
865                 870                 875                 880 


Ala Val Ile Leu His Pro Arg Leu Val Phe Glu Val Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Ile Leu Gly Pro Ala Tyr Leu Leu Lys Ala Ser Leu Leu Arg 
            900                 905                 910         


Ile Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Val Cys Thr Leu 
        915                 920                 925             


Val Lys His Leu Ala Gly Ala Arg Tyr Ile Gln Met Leu Leu Ile Thr 
    930                 935                 940                 


Ile Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Ser Pro Leu 
945                 950                 955                 960 


Ser Thr Trp Ala Ala Gln Gly Leu Arg Asp Leu Ala Ile Ala Val Glu 
                965                 970                 975     


Pro Val Val Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Val Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Lys Leu Leu  Ala Pro Ile Thr Ala  Tyr Thr Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Ala Ile Val Val Ser  Leu Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Asn Glu Gln Ala  Gly Gln Val Gln Val  Leu Ser Ser 
    1055                 1060                 1065             


Val Thr  Gln Thr Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Pro Lys 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Thr Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Asp  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Val Arg Arg Lys Asp  Asp Arg Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Ser Arg Gly His Ala  Val Gly Leu Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ala  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Ser Leu  Asp Val Ala Thr Arg  Thr Pro Ser Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Ser Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Ala Ala Tyr 
    1235                 1240                 1245             


Ala Ser  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Met Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Asp 
    1280                 1285                 1290             


Ser Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Ile Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Ala Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ser Val  Asp Ala Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Val Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Thr Val Thr  Thr Pro His Ser Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly His Glu Gly  Glu Ile Pro Phe Tyr  Gly Lys Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ala Phe Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Val Asn Ala Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Ser Gln Ile  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Val Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Ser Gly Glu  Arg Pro Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ala Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Gly Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Thr 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ala Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Ile Met  Thr Ser Ser Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Ile Ser  Ile Ile Gly Arg Leu  His Leu Asn Asp Arg  Val Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Ile Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Lys Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Met 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Thr Arg  Gln Ala Gln Asp Ile  Gln Pro Ala Ile Gln  Ser Ser Trp 
    1745                 1750                 1755             


Pro Lys  Leu Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Pro Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Met Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Ile Leu Val Asp Val  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Thr Val  Glu Asp Val Val Asn  Leu Leu Pro Ala Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Gln Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Val  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Val Leu Ser 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Ala Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Val Pro  Cys Ser Gly Ser Trp  Leu Gln Asp 
    1970                 1975                 1980             


Ile Trp  Asp Trp Val Cys Ser  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Ser  Ser Lys Leu Leu Pro  Lys Met Pro Gly Ile  Pro Phe Ile 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Val 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly His Val 
    2030                 2035                 2040             


Arg Met  Gly Thr Met Lys Ile  Thr Gly Pro Lys Thr  Cys Leu Asn 
    2045                 2050                 2055             


Leu Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Pro 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Pro Pro  Asn Tyr Lys Thr Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Val  Glu Val Thr Gln His  Gly Ser Phe 
    2090                 2095                 2100             


Ser Tyr  Val Thr Gly Leu Thr  Ser Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Val  Pro Ala Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Val  Pro Gly Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Thr  Phe Thr Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Glu Val Leu  Ala Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Ala Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Gln Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Lys Ala Thr Cys Thr  Thr His Lys 
    2210                 2215                 2220             


Thr Ala  Tyr Asp Cys Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Asp Ser Lys Val  Ile Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Ser Met Thr  Glu Val Glu Asp Asp  Arg Glu Pro 
    2255                 2260                 2265             


Ser Val  Pro Ser Glu Tyr Leu  Ile Lys Arg Arg Lys  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Pro Trp Ala Arg  Pro Asp Tyr Asn Pro  Val Leu Ile 
    2285                 2290                 2295             


Glu Thr  Trp Lys Arg Pro Gly  Tyr Glu Pro Pro Thr  Val Leu Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Thr Pro  Gln Thr Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Ala Lys Val Leu  Thr Gln Asp Asn Val  Glu Gly Ile 
    2330                 2335                 2340             


Leu Arg  Glu Met Ala Asp Lys  Val Leu Ser Pro Leu  Gln Asp Asn 
    2345                 2350                 2355             


Asn Asp  Ser Gly His Ser Thr  Gly Ala Asp Thr Gly  Gly Asp Ile 
    2360                 2365                 2370             


Val Gln  Gln Pro Ser Asp Glu  Thr Ala Ala Ser Glu  Ala Gly Ser 
    2375                 2380                 2385             


Leu Ser  Ser Met Pro Pro Leu  Glu Gly Glu Pro Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Phe Glu Pro Val Gly  Ser Ala Pro Pro Ser  Glu Gly Glu 
    2405                 2410                 2415             


Cys Glu  Val Ile Asp Ser Asp  Ser Lys Ser Trp Ser  Thr Val Ser 
    2420                 2425                 2430             


Asp Gln  Glu Asp Ser Val Ile  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Gly Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Met Arg Phe  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Ser Thr Thr Ser Arg  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Val Gln  Val Leu Asp Ala His  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Gln Asp Val Lys Arg  Ala Ala Ser Lys Val  Ser Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Val Glu Glu Ala  Cys Ala Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Lys  Ser Arg Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Arg  Arg Ala Val Asn His  Ile Arg Ser Val Trp  Glu Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Gln His Thr Pro  Ile Asp Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Ile Asp  Pro Thr Lys Gly Gly  Lys Lys Pro 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Ala Gln Lys Leu Pro  Lys Ala Ile 
    2615                 2620                 2625             


Met Gly  Pro Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Glu Arg Val 
    2630                 2635                 2640             


Asp Phe  Leu Leu Lys Ala Trp  Gly Ser Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Gln Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Gln Glu  Ala Arg Thr Val Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Thr Asn  Ser Lys Gly Gln Ser  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Phe Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Met  Thr Cys Tyr Ile Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Val Asp Pro Val Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Asn Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Leu  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Asp Ser Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Phe  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Thr  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Ile Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Leu Ala Gln Asp Thr  Leu Asn Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Asn Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Glu Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Ser  Pro Arg Glu Leu Ser  Arg Val Ala 
    2915                 2920                 2925             


Ala Thr  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ala  Gln Gly Ala 
    2945                 2950                 2955             


Arg Ala  Ala Ile Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Ser  Arg Leu Asp 
    2975                 2980                 2985             


Leu Ser  Gly Trp Phe Thr Val  Gly Ala Gly Gly Gly  Gly Ile Tyr 
    2990                 2995                 3000             


His Ser  Val Ser His Ala Arg  Pro Arg Leu Leu Leu  Leu Cys Leu 
    3005                 3010                 3015             


Leu Leu  Leu Ser Val Gly Val  Gly Ile Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


Gly Ile  Tyr His Ser Val Ser  His Ala Arg Pro Arg  Leu Leu Leu 
    3035                 3040                 3045             


Leu Cys  Leu Leu Leu Leu Ser  Val Gly Val Gly Ile  Phe Leu Leu 
    3050                 3055                 3060             


Pro Ala  Arg 
    3065     


<210>  110
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  110

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Arg Val Ile Asp Thr Ile Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Val Thr Val Pro Val Ser Ala Val 
            180                 185                 190         


Glu Val Arg Asn Ile Ser Ser Ser Tyr Tyr Ala Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Asn Ser Ile Thr Trp Gln Leu Thr Asp Ala Val Leu His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Asn Asp Asn Gly Thr Leu His Cys Trp Ile 
225                 230                 235                 240 


Gln Val Thr Pro Asn Val Ala Val Lys His Arg Gly Ala Leu Thr Arg 
                245                 250                 255     


Ser Leu Arg Thr His Val Asp Met Ile Val Met Ala Ala Thr Ala Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Val Cys Gly Ala Val Met Ile Leu Ser 
        275                 280                 285             


Gln Ala Phe Met Val Ser Pro Gln Arg His Asn Phe Thr Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Gln Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Leu Asn Trp Ser Pro Thr Leu Ala Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Ala Arg Val Pro Glu Met Val Leu Glu Ile Ile Phe Gly Gly His 
            340                 345                 350         


Trp Gly Val Val Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Ile Ala Ile Leu Leu Leu Val Ala Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr Tyr Ser Ser Gly Gln Glu Ala Gly Arg Thr Val Leu Gly Phe Thr 
385                 390                 395                 400 


Asn Leu Phe Thr Ser Gly Ala Lys Gln Asn Leu Tyr Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Met Ala Ser Leu Phe Tyr Thr His Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ser Ser Cys Arg Gly Leu Asp Asp 
    450                 455                 460                 


Phe Arg Ile Gly Trp Gly Thr Leu Glu Tyr Glu Thr His Val Thr Asn 
465                 470                 475                 480 


Asp Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys 
                485                 490                 495     


Gly Ile Val Pro Ala Arg Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Lys Gln Gly Val Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Arg Gly Ala Trp Phe Gly Cys Thr Trp Met Asn Gly Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Lys Asp 
                565                 570                 575     


Tyr Asn Ser Thr Ile Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Ala Thr Tyr Leu Lys Cys Gly Ala Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile Phe Lys Ala Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Phe Ser Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Arg Leu Glu Asp Arg Asp Arg Gly Gln Gln Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Val Leu Pro Cys Ser Phe Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Leu Thr Arg Tyr Ile Val Lys Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Ile Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Ile Ile Leu His Ser Ala Ser Ala Ala Ser Ala Asn Gly 
        755                 760                 765             


Pro Leu Trp Cys Phe Ile Phe Phe Thr Ala Ala Trp Tyr Leu Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Val Ala Thr Tyr Ser Val Leu Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Leu Leu Leu Val Leu Ala Leu Pro Gln Gln Ala Tyr Ala Leu Asp Ala 
                805                 810                 815     


Ala Glu Gln Gly Glu Leu Gly Leu Ala Ile Leu Val Ile Ile Ser Ile 
            820                 825                 830         


Phe Thr Leu Thr Pro Ala Tyr Lys Ile Leu Leu Ser Arg Ser Val Trp 
        835                 840                 845             


Trp Leu Ser Tyr Met Leu Val Leu Ala Glu Ala Gln Ile Gln Gln Trp 
    850                 855                 860                 


Val Pro Pro Leu Glu Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Val 
865                 870                 875                 880 


Ala Val Ile Leu His Pro Arg Leu Val Phe Glu Val Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Ile Leu Gly Pro Ala Tyr Leu Leu Lys Ala Ser Leu Leu Arg 
            900                 905                 910         


Ile Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Val Cys Thr Leu 
        915                 920                 925             


Val Lys His Leu Ala Gly Ala Arg Tyr Ile Gln Met Leu Leu Ile Thr 
    930                 935                 940                 


Ile Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Ser Pro Leu 
945                 950                 955                 960 


Ser Thr Trp Ala Ala Gln Gly Leu Arg Asp Leu Ala Ile Ala Val Glu 
                965                 970                 975     


Pro Val Val Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Val Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Lys Leu Leu  Ala Pro Ile Thr Ala  Tyr Thr Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Ala Ile Val Val Ser  Leu Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Asn Glu Gln Ala  Gly Gln Val Gln Val  Leu Ser Ser 
    1055                 1060                 1065             


Val Thr  Gln Thr Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Pro Lys 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Thr Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Asp  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Val Arg Arg Lys Asp  Asp Arg Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Ser Arg Gly His Ala  Val Gly Leu Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ala  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Ser Leu  Asp Val Ala Thr Arg  Thr Pro Ser Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Ser Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Ala Ala Tyr 
    1235                 1240                 1245             


Ala Ser  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Met Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Asp 
    1280                 1285                 1290             


Ser Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Ile Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Ala Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ser Val  Asp Ala Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Val Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Thr Val Thr  Thr Pro His Ser Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly His Glu Gly  Glu Ile Pro Phe Tyr  Gly Lys Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ala Phe Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Val Asn Ala Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Ser Gln Ile  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Val Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Ser Gly Glu  Arg Pro Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ala Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Gly Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Thr 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ala Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Ile Met  Thr Ser Ser Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Ile Ser  Ile Ile Gly Arg Leu  His Leu Asn Asp Arg  Val Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Ile Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Lys Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Met 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Thr Arg  Gln Ala Gln Asp Ile  Gln Pro Ala Ile Gln  Ser Ser Trp 
    1745                 1750                 1755             


Pro Lys  Leu Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Pro Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Met Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Ile Leu Val Asp Val  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Thr Val  Glu Asp Val Val Asn  Leu Leu Pro Ala Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Gln Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Val  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Val Leu Ser 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Ala Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Val Pro  Cys Ser Gly Ser Trp  Leu Gln Asp 
    1970                 1975                 1980             


Ile Trp  Asp Trp Val Cys Ser  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Ser  Ser Lys Leu Leu Pro  Lys Met Pro Gly Ile  Pro Phe Ile 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Val 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly His Val 
    2030                 2035                 2040             


Arg Met  Gly Thr Met Lys Ile  Thr Gly Pro Lys Thr  Cys Leu Asn 
    2045                 2050                 2055             


Leu Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Pro 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Pro Pro  Asn Tyr Lys Thr Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Val  Glu Val Thr Gln His  Gly Ser Phe 
    2090                 2095                 2100             


Ser Tyr  Val Thr Gly Leu Thr  Ser Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Val  Pro Ala Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Val  Pro Gly Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Thr  Phe Thr Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Glu Val Leu  Ala Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Ala Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Gln Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Lys Ala Thr Cys Thr  Thr His Lys 
    2210                 2215                 2220             


Thr Ala  Tyr Asp Cys Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Asp Ser Lys Val  Ile Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Ser Met Thr  Glu Val Glu Asp Asp  Arg Glu Pro 
    2255                 2260                 2265             


Ser Val  Pro Ser Glu Tyr Leu  Ile Lys Arg Arg Lys  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Pro Trp Ala Arg  Pro Asp Tyr Asn Pro  Val Leu Ile 
    2285                 2290                 2295             


Glu Thr  Trp Lys Arg Pro Gly  Tyr Glu Pro Pro Thr  Val Leu Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Thr Pro  Gln Thr Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Ala Lys Val Leu  Thr Gln Asp Asn Val  Glu Gly Ile 
    2330                 2335                 2340             


Leu Arg  Glu Met Ala Asp Lys  Val Leu Ser Pro Leu  Gln Asp Asn 
    2345                 2350                 2355             


Asn Asp  Ser Gly His Ser Thr  Gly Ala Asp Thr Gly  Gly Asp Ile 
    2360                 2365                 2370             


Val Gln  Gln Pro Ser Asp Glu  Thr Ala Ala Ser Glu  Ala Gly Ser 
    2375                 2380                 2385             


Leu Ser  Ser Met Pro Pro Leu  Glu Gly Glu Pro Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Phe Glu Pro Val Gly  Ser Ala Pro Pro Ser  Glu Gly Glu 
    2405                 2410                 2415             


Cys Glu  Val Ile Asp Ser Asp  Ser Lys Ser Trp Ser  Thr Val Ser 
    2420                 2425                 2430             


Asp Gln  Glu Asp Ser Val Ile  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Gly Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Met Arg Phe  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Ser Thr Thr Ser Arg  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Val Gln  Val Leu Asp Ala His  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Gln Asp Val Lys Arg  Ala Ala Ser Lys Val  Ser Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Val Glu Glu Ala  Cys Ala Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Lys  Ser Arg Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Arg  Arg Ala Val Asn His  Ile Arg Ser Val Trp  Glu Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Gln His Thr Pro  Ile Asp Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Ile Asp  Pro Thr Lys Gly Gly  Lys Lys Pro 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Ala Gln Lys Leu Pro  Lys Ala Ile 
    2615                 2620                 2625             


Met Gly  Pro Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Glu Arg Val 
    2630                 2635                 2640             


Asp Phe  Leu Leu Lys Ala Trp  Gly Ser Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Gln Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Gln Glu  Ala Arg Thr Val Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Thr Asn  Ser Lys Gly Gln Ser  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Phe Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Met  Thr Cys Tyr Ile Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Val Asp Pro Val Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Asn Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Leu  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Asp Ser Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Phe  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Thr  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Ile Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Leu Ala Gln Asp Thr  Leu Asn Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Asn Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Glu Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Ser  Pro Arg Glu Leu Ser  Arg Val Ala 
    2915                 2920                 2925             


Ala Thr  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ala  Gln Gly Ala 
    2945                 2950                 2955             


Arg Ala  Ala Ile Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Ser  Arg Leu Asp 
    2975                 2980                 2985             


Leu Ser  Gly Trp Phe Thr Val  Gly Ala Gly Gly Gly  Gly Ile Tyr 
    2990                 2995                 3000             


His Ser  Val Ser His Ala Arg  Pro Arg Leu Leu Leu  Leu Cys Leu 
    3005                 3010                 3015             


Leu Leu  Leu Ser Val Gly Val  Gly Ile Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  111
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  111

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Arg Val Ile Asp Thr Ile Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Val Thr Val Pro Val Ser Ala Val 
            180                 185                 190         


Glu Val Arg Asn Ile Ser Ser Ser Tyr Tyr Ala Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Asn Ser Ile Thr Trp Gln Leu Thr Asp Ala Val Leu His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Asn Asp Asn Gly Thr Leu His Cys Trp Ile 
225                 230                 235                 240 


Gln Val Thr Pro Asn Val Ala Val Lys His Arg Gly Ala Leu Thr Arg 
                245                 250                 255     


Ser Leu Arg Thr His Val Asp Met Ile Val Met Ala Ala Thr Ala Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Val Cys Gly Ala Val Met Ile Leu Ser 
        275                 280                 285             


Gln Ala Phe Met Val Ser Pro Gln Arg His Asn Phe Thr Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Gln Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Leu Asn Trp Ser Pro Thr Leu Ala Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Ala Arg Val Pro Glu Met Val Leu Glu Ile Ile Phe Gly Gly His 
            340                 345                 350         


Trp Gly Val Val Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Ile Ala Ile Leu Leu Leu Val Ala Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr Tyr Ser Ser Gly Gln Glu Ala Gly Arg Thr Val Leu Gly Phe Thr 
385                 390                 395                 400 


Asn Leu Phe Thr Ser Gly Ala Lys Gln Asn Leu Tyr Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Met Ala Ser Leu Phe Tyr Thr His Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ser Ser Cys Arg Gly Leu Asp Asp 
    450                 455                 460                 


Phe Arg Ile Gly Trp Gly Thr Leu Glu Tyr Glu Thr His Val Thr Asn 
465                 470                 475                 480 


Asp Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys 
                485                 490                 495     


Gly Ile Val Pro Ala Arg Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Lys Gln Gly Val Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Arg Gly Ala Trp Phe Gly Cys Thr Trp Met Asn Gly Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Lys Asp 
                565                 570                 575     


Tyr Asn Ser Thr Ile Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Ala Thr Tyr Leu Lys Cys Gly Ala Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile Phe Lys Ala Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Phe Ser Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Arg Leu Glu Asp Arg Asp Arg Gly Gln Gln Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Val Leu Pro Cys Ser Phe Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Leu Thr Arg Tyr Ile Val Lys Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Ile Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Ile Ile Leu His Ser Ala Ser Ala Ala Ser Ala Asn Gly 
        755                 760                 765             


Pro Leu Trp Phe Phe Ile Phe Phe Thr Ala Ala Trp Tyr Leu Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Val Ala Thr Tyr Ser Val Leu Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Leu Leu Leu Val Leu Ala Leu Pro Gln Gln Ala Tyr Ala Leu Asp Ala 
                805                 810                 815     


Ala Glu Gln Gly Glu Leu Gly Leu Ala Ile Leu Val Ile Ile Ser Ile 
            820                 825                 830         


Phe Thr Leu Thr Pro Ala Tyr Lys Ile Leu Leu Ser Arg Ser Val Trp 
        835                 840                 845             


Trp Leu Ser Tyr Met Leu Val Leu Ala Glu Ala Gln Ile Gln Gln Trp 
    850                 855                 860                 


Val Pro Pro Leu Glu Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Val 
865                 870                 875                 880 


Ala Val Ile Leu His Pro Arg Leu Val Phe Glu Val Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Ile Leu Gly Pro Ala Tyr Leu Leu Lys Ala Ser Leu Leu Arg 
            900                 905                 910         


Ile Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Val Cys Thr Leu 
        915                 920                 925             


Val Lys His Leu Ala Gly Ala Arg Tyr Ile Gln Met Leu Leu Ile Thr 
    930                 935                 940                 


Ile Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Ser Pro Leu 
945                 950                 955                 960 


Ser Thr Trp Ala Ala Gln Gly Leu Arg Asp Leu Ala Ile Ala Val Glu 
                965                 970                 975     


Pro Val Val Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Val Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Lys Leu Leu  Ala Pro Ile Thr Ala  Tyr Thr Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Ala Ile Val Val Ser  Leu Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Asn Glu Gln Ala  Gly Gln Val Gln Val  Leu Ser Ser 
    1055                 1060                 1065             


Val Thr  Gln Thr Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Pro Lys 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Thr Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Asp  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Val Arg Arg Lys Asp  Asp Arg Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Ser Arg Gly His Ala  Val Gly Leu Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ala  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Ser Leu  Asp Val Thr Thr Arg  Thr Pro Ser Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Ser Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Ala Ala Tyr 
    1235                 1240                 1245             


Ala Ser  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Met Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Asp 
    1280                 1285                 1290             


Ser Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Ile Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Ala Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ser Val  Asp Ala Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Val Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Thr Val Thr  Thr Pro His Ser Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly His Glu Gly  Glu Ile Pro Phe Tyr  Gly Lys Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ala Phe Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Val Asn Ala Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Ser Gln Ile  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Val Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Ser Gly Glu  Arg Pro Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ala Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Gly Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Thr 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ala Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Ile Met  Thr Ser Ser Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Ile Ser  Ile Ile Gly Arg Leu  His Leu Asn Asp Arg  Val Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Ile Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Lys Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Met 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Thr Arg  Gln Ala Gln Asp Ile  Gln Pro Ala Ile Gln  Ser Ser Trp 
    1745                 1750                 1755             


Pro Lys  Leu Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Pro Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Met Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Ile Leu Val Asp Val  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Thr Val  Glu Asp Val Val Asn  Leu Leu Pro Ala Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Gln Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Val  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Val Leu Ser 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Ala Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Val Pro  Cys Ser Gly Ser Trp  Leu Gln Asp 
    1970                 1975                 1980             


Ile Trp  Asp Trp Val Cys Ser  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Ser  Ser Lys Leu Leu Pro  Lys Met Pro Gly Ile  Pro Phe Ile 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Val 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly His Val 
    2030                 2035                 2040             


Arg Met  Gly Thr Met Lys Ile  Thr Gly Pro Lys Thr  Cys Leu Asn 
    2045                 2050                 2055             


Leu Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Pro 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Pro Pro  Asn Tyr Lys Thr Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Val  Glu Val Thr Gln His  Gly Ser Phe 
    2090                 2095                 2100             


Ser Tyr  Val Thr Gly Leu Thr  Ser Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Val  Pro Ala Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Val  Pro Gly Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Thr  Phe Thr Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Glu Val Leu  Ala Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Ala Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Gln Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Lys Ala Thr Cys Thr  Thr His Lys 
    2210                 2215                 2220             


Thr Ala  Tyr Asp Cys Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Asp Ser Lys Val  Ile Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Ser Met Thr  Glu Val Glu Asp Asp  Arg Glu Pro 
    2255                 2260                 2265             


Ser Val  Pro Ser Glu Tyr Leu  Ile Lys Arg Arg Lys  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Pro Trp Ala Arg  Pro Asp Tyr Asn Pro  Val Leu Ile 
    2285                 2290                 2295             


Glu Thr  Trp Lys Arg Pro Gly  Tyr Glu Pro Pro Thr  Val Leu Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Thr Pro  Gln Thr Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Ala Lys Val Leu  Thr Gln Asp Asn Val  Glu Gly Ile 
    2330                 2335                 2340             


Leu Arg  Glu Met Ala Asp Lys  Val Leu Ser Pro Leu  Gln Asp Asn 
    2345                 2350                 2355             


Asn Asp  Ser Gly His Ser Thr  Gly Ala Asp Thr Gly  Gly Asp Ile 
    2360                 2365                 2370             


Val Gln  Gln Pro Ser Asp Glu  Thr Ala Ala Ser Glu  Ala Gly Ser 
    2375                 2380                 2385             


Leu Ser  Ser Met Pro Pro Leu  Glu Gly Glu Pro Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Phe Glu Pro Val Gly  Ser Ala Pro Pro Ser  Glu Gly Glu 
    2405                 2410                 2415             


Cys Glu  Val Ile Asp Ser Asp  Ser Lys Ser Trp Ser  Thr Val Ser 
    2420                 2425                 2430             


Asp Gln  Glu Asp Ser Val Ile  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Gly Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Met Arg Phe  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Ser Thr Thr Ser Arg  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Val Gln  Val Leu Asp Ala His  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Gln Asp Val Lys Arg  Ala Ala Ser Lys Val  Ser Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Val Glu Glu Ala  Cys Ala Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Lys  Ser Arg Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Arg  Arg Ala Val Asn His  Ile Arg Ser Val Trp  Glu Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Gln His Thr Pro  Ile Asp Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Ile Asp  Pro Thr Lys Gly Gly  Lys Lys Pro 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Ala Gln Lys Leu Pro  Lys Ala Ile 
    2615                 2620                 2625             


Met Gly  Pro Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Glu Arg Val 
    2630                 2635                 2640             


Asp Phe  Leu Leu Lys Ala Trp  Gly Ser Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Gln Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Gln Glu  Ala Arg Thr Val Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Thr Asn  Ser Lys Gly Gln Ser  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Phe Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Met  Thr Cys Tyr Ile Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Val Asp Pro Val Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Asn Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Leu  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Asp Ser Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Phe  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Thr  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Ile Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Leu Ala Gln Asp Thr  Leu Asn Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Asn Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Glu Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Ser  Pro Arg Glu Leu Ser  Arg Val Ala 
    2915                 2920                 2925             


Ala Thr  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ala  Gln Gly Ala 
    2945                 2950                 2955             


Arg Ala  Ala Ile Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Ser  Arg Leu Asp 
    2975                 2980                 2985             


Leu Ser  Gly Trp Phe Thr Val  Gly Ala Gly Gly Gly  Gly Ile Tyr 
    2990                 2995                 3000             


His Ser  Val Ser His Ala Arg  Pro Arg Leu Leu Leu  Leu Cys Leu 
    3005                 3010                 3015             


Leu Leu  Leu Ser Val Gly Val  Gly Ile Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  112
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  112

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Arg Val Ile Asp Thr Ile Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Val Thr Val Pro Val Ser Ala Val 
            180                 185                 190         


Glu Val Arg Asn Ile Ser Ser Ser Tyr Tyr Ala Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Asn Ser Ile Thr Trp Gln Leu Thr Asp Ala Val Leu His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Asn Asp Asn Gly Thr Leu His Cys Trp Ile 
225                 230                 235                 240 


Gln Val Thr Pro Asn Val Ala Val Lys His Arg Gly Ala Leu Thr Arg 
                245                 250                 255     


Ser Leu Arg Thr His Val Asp Met Ile Val Met Ala Ala Thr Ala Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Val Cys Gly Ala Val Met Ile Leu Ser 
        275                 280                 285             


Gln Ala Phe Met Val Ser Pro Gln Arg His Asn Phe Thr Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Gln Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Leu Asn Trp Ser Pro Thr Leu Ala Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Ala Arg Val Pro Glu Met Val Leu Glu Ile Ile Phe Gly Gly His 
            340                 345                 350         


Trp Gly Val Val Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Ile Ala Ile Leu Leu Leu Val Ala Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr Tyr Ser Ser Gly Gln Glu Ala Gly Arg Thr Val Leu Gly Phe Thr 
385                 390                 395                 400 


Asn Leu Phe Thr Ser Gly Ala Lys Gln Asn Leu Tyr Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Met Ala Ser Leu Phe Tyr Thr His Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ser Ser Cys Arg Gly Leu Asp Asp 
    450                 455                 460                 


Phe Arg Ile Gly Trp Gly Thr Leu Glu Tyr Glu Thr His Val Thr Asn 
465                 470                 475                 480 


Asp Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys 
                485                 490                 495     


Gly Ile Val Pro Ala Arg Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Lys Gln Gly Val Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Arg Gly Ala Trp Phe Gly Cys Thr Trp Met Asn Gly Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Lys Asp 
                565                 570                 575     


Tyr Asn Ser Thr Ile Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Ala Thr Tyr Leu Lys Cys Gly Ala Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile Phe Lys Ala Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Phe Ser Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Arg Leu Glu Asp Arg Asp Arg Gly Gln Gln Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Val Leu Pro Cys Ser Phe Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Leu Thr Arg Tyr Ile Val Lys Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Ile Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Ile Ile Leu His Ser Ala Ser Ala Ala Ser Ala Asn Gly 
        755                 760                 765             


Pro Leu Trp Phe Phe Ile Phe Phe Thr Ala Ala Trp Tyr Leu Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Val Ala Thr Tyr Ser Val Leu Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Leu Leu Leu Val Leu Ala Leu Pro Gln Gln Ala Tyr Ala Leu Asp Ala 
                805                 810                 815     


Ala Glu Gln Gly Glu Leu Gly Leu Ala Ile Leu Val Ile Ile Ser Ile 
            820                 825                 830         


Phe Thr Leu Thr Pro Ala Tyr Lys Ile Leu Leu Ser Arg Ser Val Trp 
        835                 840                 845             


Trp Leu Ser Tyr Met Leu Val Leu Ala Glu Ala Gln Ile Gln Gln Trp 
    850                 855                 860                 


Val Pro Pro Leu Glu Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Val 
865                 870                 875                 880 


Ala Val Ile Leu His Pro Arg Leu Val Phe Glu Val Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Ile Leu Gly Pro Ala Tyr Leu Leu Lys Ala Ser Leu Leu Arg 
            900                 905                 910         


Ile Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Val Cys Thr Leu 
        915                 920                 925             


Val Lys His Leu Ala Gly Ala Arg Tyr Ile Gln Met Leu Leu Ile Thr 
    930                 935                 940                 


Ile Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Ser Pro Leu 
945                 950                 955                 960 


Ser Thr Trp Ala Ala Gln Gly Leu Arg Asp Leu Ala Ile Ala Val Glu 
                965                 970                 975     


Pro Val Val Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Val Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Lys Leu Leu  Ala Pro Ile Thr Ala  Tyr Thr Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Ala Ile Val Val Ser  Leu Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Asn Glu Gln Ala  Gly Gln Val Gln Val  Leu Ser Ser 
    1055                 1060                 1065             


Val Thr  Gln Thr Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Pro Lys 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Thr Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Asp  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Val Arg Arg Lys Asp  Asp Arg Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Ser Arg Gly His Ala  Val Gly Leu Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ala  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Ser Leu  Asp Val Ala Thr Arg  Thr Pro Ser Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Ser Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Ala Ala Tyr 
    1235                 1240                 1245             


Ala Ser  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Met Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Asp 
    1280                 1285                 1290             


Ser Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Ile Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Ala Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ser Val  Asp Ala Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Val Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Thr Val Thr  Thr Pro His Ser Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly His Glu Gly  Glu Ile Pro Phe Tyr  Gly Lys Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ala Phe Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Val Asn Ala Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Ser Gln Ile  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Val Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Ser Gly Glu  Arg Pro Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ala Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Gly Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Thr 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ala Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Ile Met  Thr Ser Ser Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Ile Ser  Ile Ile Gly Arg Leu  His Leu Asn Asp Arg  Val Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Ile Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Lys Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Met 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Thr Arg  Gln Ala Gln Asp Ile  Gln Pro Ala Ile Gln  Ser Ser Trp 
    1745                 1750                 1755             


Pro Lys  Leu Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Pro Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Met Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Ile Leu Val Asp Val  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Thr Val  Glu Asp Val Val Asn  Leu Leu Pro Ala Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Gln Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Val  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Val Leu Ser 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Ala Trp Val 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Val Pro  Cys Ser Gly Ser Trp  Leu Gln Asp 
    1970                 1975                 1980             


Ile Trp  Asp Trp Val Cys Ser  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Ser  Ser Lys Leu Leu Pro  Lys Met Pro Gly Ile  Pro Phe Ile 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Val 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly His Val 
    2030                 2035                 2040             


Arg Met  Gly Thr Met Lys Ile  Thr Gly Pro Lys Thr  Cys Leu Asn 
    2045                 2050                 2055             


Leu Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Pro 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Pro Pro  Asn Tyr Lys Thr Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Val  Glu Val Thr Gln His  Gly Ser Phe 
    2090                 2095                 2100             


Ser Tyr  Val Thr Gly Leu Thr  Ser Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Val  Pro Ala Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Val  Pro Gly Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Thr  Phe Thr Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Glu Val Leu  Ala Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Ala Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Gln Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Lys Ala Thr Cys Thr  Thr His Lys 
    2210                 2215                 2220             


Thr Ala  Tyr Asp Cys Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Asp Ser Lys Val  Ile Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Ser Met Thr  Glu Val Glu Asp Asp  Arg Glu Pro 
    2255                 2260                 2265             


Ser Val  Pro Ser Glu Tyr Leu  Ile Lys Arg Arg Lys  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Pro Trp Ala Arg  Pro Asp Tyr Asn Pro  Val Leu Ile 
    2285                 2290                 2295             


Glu Thr  Trp Lys Arg Pro Gly  Tyr Glu Pro Pro Thr  Val Leu Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Thr Pro  Gln Thr Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Ala Lys Val Leu  Thr Gln Asp Asn Val  Glu Gly Ile 
    2330                 2335                 2340             


Leu Arg  Glu Met Ala Asp Lys  Val Leu Ser Pro Leu  Gln Asp Asn 
    2345                 2350                 2355             


Asn Asp  Ser Gly His Ser Thr  Gly Ala Asp Thr Gly  Gly Asp Ile 
    2360                 2365                 2370             


Val Gln  Gln Pro Ser Asp Glu  Thr Ala Ala Ser Glu  Ala Gly Ser 
    2375                 2380                 2385             


Leu Ser  Ser Met Pro Pro Leu  Glu Gly Glu Pro Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Phe Glu Pro Val Gly  Ser Ala Pro Pro Ser  Glu Gly Glu 
    2405                 2410                 2415             


Cys Glu  Val Ile Asp Ser Asp  Ser Lys Ser Trp Ser  Thr Val Ser 
    2420                 2425                 2430             


Asp Gln  Glu Asp Ser Val Ile  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Gly Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Met Arg Phe  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Ser Thr Thr Ser Arg  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Val Gln  Val Leu Asp Ala His  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Gln Asp Val Lys Arg  Ala Ala Ser Lys Val  Ser Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Val Glu Glu Ala  Cys Ala Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Lys  Ser Arg Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Arg  Arg Ala Val Asn His  Ile Arg Ser Val Trp  Glu Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Gln His Thr Pro  Ile Asp Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Ile Asp  Pro Thr Lys Gly Gly  Lys Lys Pro 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Ala Gln Lys Leu Pro  Lys Ala Ile 
    2615                 2620                 2625             


Met Gly  Pro Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Glu Arg Val 
    2630                 2635                 2640             


Asp Phe  Leu Leu Lys Ala Trp  Gly Ser Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Gln Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Gln Glu  Ala Arg Thr Val Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Thr Asn  Ser Lys Gly Gln Ser  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Phe Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Met  Thr Cys Tyr Ile Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Val Asp Pro Val Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Asn Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Leu  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Asp Ser Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Phe  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Thr  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Ile Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Leu Ala Gln Asp Thr  Leu Asn Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Asn Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Glu Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Ser  Pro Arg Glu Leu Ser  Arg Val Ala 
    2915                 2920                 2925             


Ala Thr  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ala  Gln Gly Ala 
    2945                 2950                 2955             


Arg Ala  Ala Ile Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Ser  Arg Leu Asp 
    2975                 2980                 2985             


Leu Ser  Gly Trp Phe Thr Val  Gly Ala Gly Gly Gly  Gly Ile Tyr 
    2990                 2995                 3000             


His Ser  Val Ser His Ala Arg  Pro Arg Leu Leu Leu  Leu Cys Leu 
    3005                 3010                 3015             


Leu Leu  Leu Ser Val Gly Val  Gly Ile Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  113
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  113

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Arg Val Ile Asp Thr Ile Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Val Thr Val Pro Val Ser Ala Val 
            180                 185                 190         


Glu Val Arg Asn Ile Ser Ser Ser Tyr Tyr Ala Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Asn Ser Ile Thr Trp Gln Leu Thr Asp Ala Val Leu His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Asn Asp Asn Gly Thr Leu His Cys Trp Ile 
225                 230                 235                 240 


Gln Val Thr Pro Asn Val Ala Val Lys His Arg Gly Ala Leu Thr Arg 
                245                 250                 255     


Ser Leu Arg Thr His Val Asp Met Ile Val Met Ala Ala Thr Ala Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Val Cys Gly Ala Val Met Ile Leu Ser 
        275                 280                 285             


Gln Ala Phe Met Val Ser Pro Gln Arg His Asn Phe Thr Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Gln Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Leu Asn Trp Ser Pro Thr Leu Ala Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Ala Arg Val Pro Glu Met Val Leu Glu Ile Ile Phe Gly Gly His 
            340                 345                 350         


Trp Gly Val Val Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Ile Ala Ile Leu Leu Leu Val Ala Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr Tyr Ser Ser Gly Gln Glu Ala Gly Arg Thr Val Leu Gly Phe Thr 
385                 390                 395                 400 


Asn Leu Phe Thr Ser Gly Ala Lys Gln Asn Leu Tyr Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Met Ala Ser Leu Phe Tyr Thr His Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ser Ser Cys Arg Gly Leu Asp Asp 
    450                 455                 460                 


Phe Arg Ile Gly Trp Gly Thr Leu Glu Tyr Glu Thr His Val Thr Asn 
465                 470                 475                 480 


Asp Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys 
                485                 490                 495     


Gly Ile Val Pro Ala Arg Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Lys Gln Gly Val Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Arg Gly Ala Trp Phe Gly Cys Thr Trp Met Asn Gly Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Lys Asp 
                565                 570                 575     


Tyr Asn Ser Thr Ile Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Ala Thr Tyr Leu Lys Cys Gly Ala Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile Phe Lys Ala Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Phe Ser Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Arg Leu Glu Asp Arg Asp Arg Gly Gln Gln Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Val Leu Pro Cys Ser Phe Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Leu Thr Arg Tyr Ile Val Lys Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Ile Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Ile Ile Leu His Ser Ala Ser Ala Ala Ser Ala Asn Gly 
        755                 760                 765             


Pro Leu Trp Phe Phe Ile Phe Phe Thr Ala Ala Trp Tyr Leu Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Val Ala Thr Tyr Ser Val Leu Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Leu Leu Leu Val Leu Ala Leu Pro Gln Gln Ala Tyr Ala Leu Asp Ala 
                805                 810                 815     


Ala Glu Gln Gly Glu Leu Gly Leu Ala Ile Leu Val Ile Ile Ser Ile 
            820                 825                 830         


Phe Thr Leu Thr Pro Ala Tyr Lys Ile Leu Leu Ser Arg Ser Val Trp 
        835                 840                 845             


Trp Leu Ser Tyr Met Leu Val Leu Ala Glu Ala Gln Ile Gln Gln Trp 
    850                 855                 860                 


Val Pro Pro Leu Glu Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Val 
865                 870                 875                 880 


Ala Val Ile Leu His Pro Arg Leu Val Phe Glu Val Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Ile Leu Gly Pro Ala Tyr Leu Leu Lys Ala Ser Leu Leu Arg 
            900                 905                 910         


Ile Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Val Cys Thr Leu 
        915                 920                 925             


Val Lys His Leu Ala Gly Ala Arg Tyr Ile Gln Met Leu Leu Ile Thr 
    930                 935                 940                 


Ile Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Ser Pro Leu 
945                 950                 955                 960 


Ser Thr Trp Ala Ala Gln Gly Leu Arg Asp Leu Ala Ile Ala Val Glu 
                965                 970                 975     


Pro Val Val Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Val Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Lys Leu Leu  Ala Pro Ile Thr Ala  Tyr Thr Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Ala Ile Val Val Ser  Leu Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Asn Glu Gln Ala  Gly Gln Val Gln Val  Leu Ser Ser 
    1055                 1060                 1065             


Val Thr  Gln Thr Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Pro Lys 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Thr Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Asp  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Val Arg Arg Lys Asp  Asp Arg Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Ser Arg Gly His Ala  Val Gly Leu Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ala  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Ser Leu  Asp Val Ala Thr Arg  Thr Pro Ser Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Ser Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Ala Ala Tyr 
    1235                 1240                 1245             


Ala Ser  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Met Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Asp 
    1280                 1285                 1290             


Ser Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Ile Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Ala Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ser Val  Asp Ala Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Val Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Thr Val Thr  Thr Pro His Ser Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly His Glu Gly  Glu Ile Pro Phe Tyr  Gly Lys Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ala Phe Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Val Asn Ala Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Ser Gln Ile  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Val Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Ser Gly Glu  Arg Pro Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ala Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Gly Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Thr 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ala Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Ile Met  Thr Ser Ser Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Ile Ser  Ile Ile Gly Arg Leu  His Leu Asn Asp Arg  Val Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Ile Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Lys Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Met 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Thr Arg  Gln Ala Gln Asp Ile  Gln Pro Ala Ile Gln  Ser Ser Trp 
    1745                 1750                 1755             


Pro Lys  Leu Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Pro Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Met Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Ile Leu Val Asp Val  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Thr Val  Glu Asp Val Val Asn  Leu Leu Pro Ala Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Gln Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Val  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Val Leu Ser 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Ala Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Val Pro  Cys Ser Gly Ser Trp  Leu Gln Asp 
    1970                 1975                 1980             


Ile Trp  Asp Trp Val Cys Ser  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Ser  Ser Lys Leu Leu Pro  Lys Met Pro Gly Ile  Pro Phe Ile 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Val 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly His Val 
    2030                 2035                 2040             


Arg Met  Gly Thr Met Lys Ile  Thr Gly Pro Lys Thr  Cys Leu Asn 
    2045                 2050                 2055             


Leu Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Pro 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Pro Pro  Asn Tyr Lys Thr Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Val  Glu Val Thr Gln His  Gly Ser Phe 
    2090                 2095                 2100             


Ser Tyr  Val Thr Gly Leu Thr  Ser Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Val  Pro Ala Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Val  Pro Gly Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Thr  Phe Thr Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Glu Val Leu  Ala Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Ala Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Gln Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Lys Ala Thr Cys Thr  Thr His Lys 
    2210                 2215                 2220             


Thr Ala  Tyr Asp Cys Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Asp Ser Lys Val  Ile Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Ser Met Thr  Glu Val Glu Asp Asp  Arg Glu Pro 
    2255                 2260                 2265             


Ser Val  Pro Ser Glu Tyr Leu  Ile Lys Arg Arg Lys  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Pro Trp Ala Arg  Pro Asp Tyr Asn Pro  Val Leu Ile 
    2285                 2290                 2295             


Glu Thr  Trp Lys Arg Pro Gly  Tyr Glu Pro Pro Thr  Val Leu Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Thr Pro  Gln Thr Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Ala Lys Val Leu  Thr Gln Asp Asn Val  Glu Gly Ile 
    2330                 2335                 2340             


Leu Arg  Glu Met Ala Asp Lys  Val Leu Ser Pro Leu  Gln Asp Asn 
    2345                 2350                 2355             


Asn Asp  Ser Gly His Ser Thr  Gly Ala Asp Thr Gly  Gly Asp Ile 
    2360                 2365                 2370             


Val Gln  Gln Pro Ser Asp Glu  Thr Ala Ala Ser Glu  Ala Gly Ser 
    2375                 2380                 2385             


Leu Ser  Ser Met Pro Pro Leu  Glu Gly Glu Pro Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Phe Glu Pro Val Gly  Ser Ala Pro Pro Ser  Glu Gly Glu 
    2405                 2410                 2415             


Cys Glu  Val Ile Asp Ser Asp  Ser Lys Ser Trp Ser  Thr Val Ser 
    2420                 2425                 2430             


Asp Gln  Glu Asp Ser Val Ile  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Gly Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Met Arg Phe  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Ser Thr Thr Ser Arg  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Val Gln  Val Leu Asp Ala His  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Gln Asp Val Lys Arg  Ala Ala Ser Lys Val  Ser Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Val Glu Glu Ala  Cys Ala Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Lys  Ser Arg Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Arg  Arg Ala Val Asn His  Ile Arg Ser Val Trp  Glu Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Gln His Thr Pro  Ile Asp Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Ile Asp  Pro Thr Lys Gly Gly  Lys Lys Pro 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Ala Gln Lys Leu Pro  Lys Ala Ile 
    2615                 2620                 2625             


Met Gly  Pro Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Glu Arg Val 
    2630                 2635                 2640             


Asp Phe  Leu Leu Lys Ala Trp  Gly Ser Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Gln Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Gln Glu  Ala Arg Thr Val Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Thr Asn  Ser Lys Gly Gln Ser  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Phe Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Met  Thr Cys Tyr Ile Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Val Asp Pro Val Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Asn Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Leu  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Asp Ser Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Phe  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Thr  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Ile Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Leu Ala Gln Asp Thr  Leu Asn Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Ser Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Glu Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Ser  Pro Arg Glu Leu Ser  Arg Val Ala 
    2915                 2920                 2925             


Ala Thr  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ala  Gln Gly Ala 
    2945                 2950                 2955             


Arg Ala  Ala Ile Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Ser  Arg Leu Asp 
    2975                 2980                 2985             


Leu Ser  Gly Trp Phe Thr Val  Gly Ala Gly Gly Gly  Gly Ile Tyr 
    2990                 2995                 3000             


His Ser  Val Ser His Ala Arg  Pro Arg Leu Leu Leu  Leu Cys Leu 
    3005                 3010                 3015             


Leu Leu  Leu Ser Val Gly Val  Gly Ile Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  114
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  114

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Arg Val Ile Asp Thr Ile Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Val Thr Val Pro Val Ser Ala Val 
            180                 185                 190         


Glu Val Arg Asn Ile Ser Ser Ser Tyr Tyr Ala Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Asn Ser Ile Thr Trp Gln Leu Thr Asp Ala Val Leu His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Asn Asp Asn Gly Thr Leu His Cys Trp Ile 
225                 230                 235                 240 


Gln Val Thr Pro Asn Val Ala Val Lys His Arg Gly Ala Leu Thr Arg 
                245                 250                 255     


Ser Leu Arg Thr His Val Asp Met Ile Val Met Ala Ala Thr Ala Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Val Cys Gly Ala Val Met Ile Leu Ser 
        275                 280                 285             


Gln Ala Phe Met Val Ser Pro Gln Arg His Asn Phe Thr Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Gln Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Leu Asn Trp Ser Pro Thr Leu Ala Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Ala Arg Val Pro Glu Met Val Leu Glu Ile Ile Phe Gly Gly His 
            340                 345                 350         


Trp Gly Val Val Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Ile Ala Ile Leu Leu Leu Val Ala Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr Tyr Ser Ser Gly Gln Glu Ala Gly Arg Thr Val Leu Gly Phe Thr 
385                 390                 395                 400 


Asn Leu Phe Thr Ser Gly Ala Lys Gln Asn Leu Tyr Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Met Ala Ser Leu Phe Tyr Thr His Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ser Ser Cys Arg Gly Leu Asp Asp 
    450                 455                 460                 


Phe Arg Ile Gly Trp Gly Thr Leu Glu Tyr Glu Thr His Val Thr Asn 
465                 470                 475                 480 


Asp Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys 
                485                 490                 495     


Gly Ile Val Pro Ala Arg Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Lys Gln Gly Val Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Arg Gly Ala Trp Phe Gly Cys Thr Trp Met Asn Gly Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Lys Asp 
                565                 570                 575     


Tyr Asn Ser Thr Ile Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Ala Thr Tyr Leu Lys Cys Gly Ala Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile Phe Lys Ala Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Phe Ser Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Arg Leu Glu Asp Arg Asp Arg Gly Gln Gln Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Val Leu Pro Cys Ser Phe Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Leu Thr Arg Tyr Ile Val Lys Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Ile Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Ile Ile Leu His Ser Ala Ser Ala Ala Ser Ala Asn Gly 
        755                 760                 765             


Pro Leu Trp Phe Phe Ile Phe Phe Thr Ala Ala Trp Tyr Leu Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Val Ala Thr Tyr Ser Val Leu Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Leu Leu Leu Val Leu Ala Leu Pro Gln Gln Ala Tyr Ala Leu Asp Ala 
                805                 810                 815     


Ala Glu Gln Gly Glu Leu Gly Leu Ala Ile Leu Val Ile Ile Ser Ile 
            820                 825                 830         


Phe Thr Leu Thr Pro Ala Tyr Lys Ile Leu Leu Ser Arg Ser Val Trp 
        835                 840                 845             


Trp Leu Ser Tyr Met Leu Val Leu Ala Glu Ala Gln Ile Gln Gln Arg 
    850                 855                 860                 


Val Pro Pro Leu Glu Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Val 
865                 870                 875                 880 


Ala Val Ile Leu His Pro Arg Leu Val Phe Glu Val Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Ile Leu Gly Pro Ala Tyr Leu Leu Lys Ala Ser Leu Leu Arg 
            900                 905                 910         


Ile Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Val Cys Thr Leu 
        915                 920                 925             


Val Lys His Leu Ala Gly Ala Arg Tyr Ile Gln Met Leu Leu Ile Thr 
    930                 935                 940                 


Ile Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Ser Pro Leu 
945                 950                 955                 960 


Ser Thr Trp Ala Ala Gln Gly Leu Arg Asp Leu Ala Ile Ala Val Glu 
                965                 970                 975     


Pro Val Val Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Val Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Lys Leu Leu  Ala Pro Ile Thr Ala  Tyr Thr Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Ala Ile Val Val Ser  Leu Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Asn Glu Gln Ala  Gly Gln Val Gln Val  Leu Ser Ser 
    1055                 1060                 1065             


Val Thr  Gln Thr Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Pro Lys 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Thr Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Asp  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Val Arg Arg Lys Asp  Asp Arg Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Ser Arg Gly His Ala  Val Gly Leu Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ala  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Ser Leu  Asp Val Ala Thr Arg  Thr Pro Ser Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Ser Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Ala Ala Tyr 
    1235                 1240                 1245             


Ala Ser  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Met Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Asp 
    1280                 1285                 1290             


Ser Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Ile Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Ala Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ser Val  Asp Ala Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Val Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Thr Val Thr  Thr Pro His Ser Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly His Glu Gly  Glu Ile Pro Phe Tyr  Gly Lys Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ala Phe Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Val Asn Ala Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Ser Gln Ile  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Val Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Ser Gly Glu  Arg Pro Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ala Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Gly Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Thr 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ala Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Ile Met  Thr Ser Ser Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Ile Ser  Ile Ile Gly Arg Leu  His Leu Asn Asp Arg  Val Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Ile Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Lys Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Met 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Thr Arg  Gln Ala Gln Asp Ile  Gln Pro Ala Ile Gln  Ser Ser Trp 
    1745                 1750                 1755             


Pro Lys  Leu Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Pro Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Met Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Ile Leu Val Asp Val  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Thr Val  Glu Asp Val Val Asn  Leu Leu Pro Ala Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Gln Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Val  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Val Leu Ser 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Ala Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Val Pro  Cys Ser Gly Ser Trp  Leu Gln Asp 
    1970                 1975                 1980             


Ile Trp  Asp Trp Val Cys Ser  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Ser  Ser Lys Leu Leu Pro  Lys Met Pro Gly Ile  Pro Phe Ile 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Val 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly His Val 
    2030                 2035                 2040             


Arg Met  Gly Thr Met Lys Ile  Thr Gly Pro Lys Thr  Cys Leu Asn 
    2045                 2050                 2055             


Leu Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Pro 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Pro Pro  Asn Tyr Lys Thr Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Val  Glu Val Thr Gln His  Gly Ser Phe 
    2090                 2095                 2100             


Ser Tyr  Val Thr Gly Leu Thr  Ser Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Val  Pro Ala Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Val  Pro Gly Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Thr  Phe Thr Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Glu Val Leu  Ala Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Ala Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Gln Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Lys Ala Thr Cys Thr  Thr His Lys 
    2210                 2215                 2220             


Thr Ala  Tyr Asp Cys Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Asp Ser Lys Val  Ile Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Ser Met Thr  Glu Val Glu Asp Asp  Arg Glu Pro 
    2255                 2260                 2265             


Ser Val  Pro Ser Glu Tyr Leu  Ile Lys Arg Arg Lys  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Pro Trp Ala Arg  Pro Asp Tyr Asn Pro  Val Leu Ile 
    2285                 2290                 2295             


Glu Thr  Trp Lys Arg Pro Gly  Tyr Glu Pro Pro Thr  Val Leu Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Thr Pro  Gln Thr Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Ala Lys Val Leu  Thr Gln Asp Asn Val  Glu Gly Ile 
    2330                 2335                 2340             


Leu Arg  Glu Met Ala Asp Lys  Val Leu Ser Pro Leu  Gln Asp Asn 
    2345                 2350                 2355             


Asn Asp  Ser Gly His Ser Thr  Gly Ala Asp Thr Gly  Gly Asp Ile 
    2360                 2365                 2370             


Val Gln  Gln Pro Ser Asp Glu  Thr Ala Ala Ser Glu  Ala Gly Ser 
    2375                 2380                 2385             


Leu Ser  Ser Met Pro Pro Leu  Glu Gly Glu Pro Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Phe Glu Pro Val Gly  Ser Ala Pro Pro Ser  Glu Gly Glu 
    2405                 2410                 2415             


Cys Glu  Val Ile Asp Ser Asp  Ser Lys Ser Trp Ser  Thr Val Ser 
    2420                 2425                 2430             


Asp Gln  Glu Asp Ser Val Ile  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Gly Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Met Arg Phe  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Ser Thr Thr Ser Arg  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Val Gln  Val Leu Asp Ala His  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Gln Asp Val Lys Arg  Ala Ala Ser Lys Val  Ser Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Val Glu Glu Ala  Cys Ala Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Lys  Ser Arg Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Arg  Arg Ala Val Asn His  Ile Arg Ser Val Trp  Glu Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Gln His Thr Pro  Ile Asp Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Ile Asp  Pro Thr Lys Gly Gly  Lys Lys Pro 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Ala Gln Lys Leu Pro  Lys Ala Ile 
    2615                 2620                 2625             


Met Gly  Pro Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Glu Arg Val 
    2630                 2635                 2640             


Asp Phe  Leu Leu Lys Ala Trp  Gly Ser Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Gln Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Gln Glu  Ala Arg Thr Val Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Thr Asn  Ser Lys Gly Gln Ser  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Phe Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Met  Thr Cys Tyr Ile Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Val Asp Pro Val Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Asn Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Leu  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Asp Ser Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Phe  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Thr  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Ile Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Leu Ala Gln Asp Thr  Leu Asn Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Asn Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Glu Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Ser  Pro Arg Glu Leu Ser  Arg Val Ala 
    2915                 2920                 2925             


Ala Thr  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ala  Gln Gly Ala 
    2945                 2950                 2955             


Arg Ala  Ala Ile Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Ser  Arg Leu Asp 
    2975                 2980                 2985             


Leu Ser  Gly Trp Phe Thr Val  Gly Ala Gly Gly Gly  Gly Ile Tyr 
    2990                 2995                 3000             


His Ser  Val Ser His Ala Arg  Pro Arg Leu Leu Leu  Leu Cys Leu 
    3005                 3010                 3015             


Leu Leu  Leu Ser Val Gly Val  Gly Ile Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  115
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  115

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Arg Val Ile Asp Thr Ile Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Val Thr Val Pro Val Ser Ala Val 
            180                 185                 190         


Glu Val Arg Asn Ile Ser Ser Ser Tyr Tyr Ala Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Asn Ser Ile Thr Trp Gln Leu Thr Asp Ala Val Leu His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Asn Asp Asn Gly Thr Leu His Cys Trp Ile 
225                 230                 235                 240 


Gln Val Thr Pro Asn Val Ala Val Lys His Arg Gly Ala Leu Thr Arg 
                245                 250                 255     


Ser Leu Arg Thr His Val Asp Met Ile Val Met Ala Ala Thr Ala Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Val Cys Gly Ala Val Met Ile Leu Ser 
        275                 280                 285             


Gln Ala Phe Met Val Ser Pro Gln Arg His Asn Phe Thr Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Gln Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Leu Asn Trp Ser Pro Thr Leu Ala Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Ala Arg Val Pro Glu Met Val Leu Glu Ile Ile Phe Gly Gly His 
            340                 345                 350         


Trp Gly Val Val Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Ile Ala Ile Leu Leu Leu Val Ala Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr Tyr Ser Ser Gly Gln Glu Ala Gly Arg Thr Val Leu Gly Phe Thr 
385                 390                 395                 400 


Asn Leu Phe Thr Ser Gly Ala Lys Gln Asn Leu Tyr Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Met Ala Ser Leu Phe Tyr Thr His Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ser Ser Cys Arg Gly Leu Asp Asp 
    450                 455                 460                 


Phe Arg Ile Gly Trp Gly Thr Leu Glu Tyr Glu Thr His Val Thr Asn 
465                 470                 475                 480 


Asp Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys 
                485                 490                 495     


Gly Ile Val Pro Ala Arg Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Lys Gln Gly Val Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Arg Gly Ala Trp Phe Gly Cys Thr Trp Met Asn Gly Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Lys Asp 
                565                 570                 575     


Tyr Asn Ser Thr Ile Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Ala Thr Tyr Leu Lys Cys Gly Ala Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile Phe Lys Ala Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Phe Ser Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Arg Leu Glu Asp Arg Asp Arg Gly Gln Gln Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Val Leu Pro Cys Ser Phe Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Leu Thr Arg Tyr Ile Val Lys Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Ile Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Ile Ile Leu His Ser Ala Ser Ala Ala Ser Ala Asn Gly 
        755                 760                 765             


Pro Leu Trp Phe Phe Ile Phe Phe Thr Ala Ala Trp Tyr Leu Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Val Ala Thr Tyr Ser Val Leu Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Leu Leu Leu Val Leu Ala Leu Pro Gln Gln Ala Tyr Ala Leu Asp Ala 
                805                 810                 815     


Ala Glu Gln Gly Glu Leu Gly Leu Ala Ile Leu Val Ile Ile Ser Ile 
            820                 825                 830         


Phe Thr Leu Thr Pro Ala Tyr Lys Ile Leu Leu Ser Arg Ser Val Trp 
        835                 840                 845             


Trp Leu Ser Tyr Met Leu Val Leu Ala Glu Ala Gln Ile Gln Gln Trp 
    850                 855                 860                 


Val Pro Pro Leu Glu Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Val 
865                 870                 875                 880 


Ala Val Ile Leu His Pro Arg Leu Val Phe Glu Val Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Ile Leu Gly Pro Ala Tyr Leu Leu Lys Ala Ser Leu Leu Arg 
            900                 905                 910         


Ile Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Val Cys Thr Leu 
        915                 920                 925             


Val Lys His Leu Ala Gly Ala Arg Tyr Ile Gln Met Leu Leu Ile Thr 
    930                 935                 940                 


Ile Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Ser Pro Leu 
945                 950                 955                 960 


Ser Thr Trp Ala Ala Gln Gly Leu Arg Asp Leu Ala Ile Ala Val Glu 
                965                 970                 975     


Pro Val Val Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Val Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Lys Leu Leu  Ala Pro Ile Thr Ala  Tyr Thr Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Ala Ile Val Val Ser  Leu Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Asn Glu Gln Ala  Gly Gln Val Gln Val  Leu Ser Ser 
    1055                 1060                 1065             


Val Thr  Gln Thr Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Pro Lys 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Thr Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Asp  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Val Arg Arg Lys Asp  Asp Arg Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Ser Arg Gly His Ala  Val Gly Leu Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ala  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Ser Leu  Asp Val Ala Thr Arg  Thr Pro Ser Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Ser Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Ala Ala Tyr 
    1235                 1240                 1245             


Ala Ser  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Met Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Asp 
    1280                 1285                 1290             


Ser Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Ile Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Ala Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ser Val  Asp Ala Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Val Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Thr Val Thr  Thr Pro His Ser Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly His Glu Gly  Glu Ile Pro Phe Tyr  Gly Lys Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ala Phe Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Val Asn Ala Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Ser Gln Ile  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Val Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Ser Gly Glu  Arg Pro Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ala Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Gly Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Thr 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ala Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Ile Met  Thr Ser Ser Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Ile Ser  Ile Ile Gly Arg Leu  His Leu Asn Asp Arg  Val Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Ile Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Lys Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Met 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Thr Arg  Gln Ala Gln Asp Ile  Gln Pro Ala Ile Gln  Ser Ser Trp 
    1745                 1750                 1755             


Pro Lys  Leu Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Pro Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Met Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Ile Leu Val Asp Val  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Thr Val  Glu Asp Val Val Asn  Leu Leu Pro Ala Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Gln Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Val  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Val Leu Ser 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Ala Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Val Pro  Cys Ser Gly Ser Trp  Leu Gln Asp 
    1970                 1975                 1980             


Ile Trp  Asp Trp Val Cys Ser  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Ser  Ser Lys Leu Leu Pro  Lys Met Pro Gly Ile  Pro Phe Ile 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Val 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly His Val 
    2030                 2035                 2040             


Arg Met  Gly Thr Met Lys Ile  Thr Gly Pro Lys Thr  Cys Leu Asn 
    2045                 2050                 2055             


Leu Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Pro 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Pro Pro  Asn Tyr Lys Thr Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Val  Glu Val Thr Gln His  Gly Ser Phe 
    2090                 2095                 2100             


Ser Tyr  Val Thr Gly Leu Thr  Ser Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Val  Pro Ala Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Val  Pro Gly Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Thr  Phe Thr Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Glu Val Leu  Ala Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Ala Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Gln Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Lys Ala Thr Cys Thr  Thr His Lys 
    2210                 2215                 2220             


Thr Ala  Tyr Asp Cys Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Asp Ser Lys Val  Ile Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Ser Met Thr  Glu Val Val Asp Asp  Arg Glu Pro 
    2255                 2260                 2265             


Ser Val  Pro Ser Glu Tyr Leu  Ile Lys Arg Arg Lys  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Pro Trp Ala Arg  Pro Asp Tyr Asn Pro  Val Leu Ile 
    2285                 2290                 2295             


Glu Thr  Trp Lys Arg Pro Gly  Tyr Glu Pro Pro Thr  Val Leu Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Thr Pro  Gln Thr Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Ala Lys Val Leu  Thr Gln Asp Asn Val  Glu Gly Ile 
    2330                 2335                 2340             


Leu Arg  Glu Met Ala Asp Lys  Val Leu Ser Pro Leu  Gln Asp Asn 
    2345                 2350                 2355             


Asn Asp  Ser Gly His Ser Thr  Gly Ala Asp Thr Gly  Gly Asp Ile 
    2360                 2365                 2370             


Val Gln  Gln Pro Ser Asp Glu  Thr Ala Ala Ser Glu  Ala Gly Ser 
    2375                 2380                 2385             


Leu Ser  Ser Met Pro Pro Leu  Glu Gly Glu Pro Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Phe Glu Pro Val Gly  Ser Ala Pro Pro Ser  Glu Gly Glu 
    2405                 2410                 2415             


Cys Glu  Val Ile Asp Ser Asp  Ser Lys Ser Trp Ser  Thr Val Ser 
    2420                 2425                 2430             


Asp Gln  Glu Asp Ser Val Ile  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Gly Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Met Arg Phe  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Ser Thr Thr Ser Arg  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Val Gln  Val Leu Asp Ala His  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Gln Asp Val Lys Arg  Ala Ala Ser Lys Val  Ser Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Val Glu Glu Ala  Cys Ala Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Lys  Ser Arg Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Arg  Arg Ala Val Asn His  Ile Arg Ser Val Trp  Glu Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Gln His Thr Pro  Ile Asp Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Ile Asp  Pro Thr Lys Gly Gly  Lys Lys Pro 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Ala Gln Lys Leu Pro  Lys Ala Ile 
    2615                 2620                 2625             


Met Gly  Pro Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Glu Arg Val 
    2630                 2635                 2640             


Asp Phe  Leu Leu Lys Ala Trp  Gly Ser Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Gln Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Gln Glu  Ala Arg Thr Val Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Thr Asn  Ser Lys Gly Gln Ser  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Phe Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Met  Thr Cys Tyr Ile Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Val Asp Pro Val Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Asn Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Leu  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Asp Ser Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Phe  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Thr  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Ile Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Leu Ala Gln Asp Thr  Leu Asn Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Asn Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Glu Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Ser  Pro Arg Glu Leu Ser  Arg Val Ala 
    2915                 2920                 2925             


Ala Thr  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ala  Gln Gly Ala 
    2945                 2950                 2955             


Arg Ala  Ala Ile Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Ser  Arg Leu Asp 
    2975                 2980                 2985             


Leu Ser  Gly Trp Phe Thr Val  Gly Ala Gly Gly Gly  Gly Ile Tyr 
    2990                 2995                 3000             


His Ser  Val Ser His Ala Arg  Pro Arg Leu Leu Leu  Leu Cys Leu 
    3005                 3010                 3015             


Leu Leu  Leu Ser Val Gly Val  Gly Ile Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  116
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  116

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Arg Val Ile Asp Thr Ile Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Val Thr Val Pro Val Ser Ala Val 
            180                 185                 190         


Glu Val Arg Asn Ile Ser Ser Ser Tyr Tyr Ala Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Asn Ser Ile Thr Trp Gln Leu Thr Asp Ala Val Leu His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Asn Asp Asn Gly Thr Leu His Cys Trp Ile 
225                 230                 235                 240 


Gln Val Thr Pro Asn Val Ala Val Lys His Arg Gly Ala Leu Thr Arg 
                245                 250                 255     


Ser Leu Arg Thr His Val Asp Met Ile Val Met Ala Ala Thr Ala Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Val Cys Gly Ala Val Met Ile Leu Ser 
        275                 280                 285             


Gln Ala Phe Met Val Ser Pro Gln Arg His Asn Phe Thr Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Gln Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Leu Asn Trp Ser Pro Thr Leu Ala Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Ala Arg Val Pro Glu Met Val Leu Glu Ile Ile Phe Gly Gly His 
            340                 345                 350         


Trp Gly Val Val Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Ile Ala Ile Leu Leu Leu Val Ala Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr Tyr Ser Ser Gly Gln Glu Ala Gly Arg Thr Val Leu Gly Phe Thr 
385                 390                 395                 400 


Asn Leu Phe Thr Ser Gly Ala Lys Gln Asn Leu Tyr Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Met Ala Ser Leu Phe Tyr Thr His Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ser Ser Cys Arg Gly Leu Asp Asp 
    450                 455                 460                 


Phe Arg Ile Gly Trp Gly Thr Leu Glu Tyr Glu Thr His Val Thr Asn 
465                 470                 475                 480 


Asp Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys 
                485                 490                 495     


Gly Ile Val Pro Ala Arg Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Lys Gln Gly Val Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Arg Gly Ala Trp Phe Gly Cys Thr Trp Met Asn Gly Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Lys Asp 
                565                 570                 575     


Tyr Asn Ser Thr Ile Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Ala Thr Tyr Leu Lys Cys Gly Ala Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile Phe Lys Ala Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Phe Ser Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Arg Leu Glu Asp Arg Asp Arg Gly Gln Gln Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Val Leu Pro Cys Ser Phe Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Leu Thr Arg Tyr Ile Val Lys Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Ile Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Ile Ile Leu His Ser Ala Ser Ala Ala Ser Ala Asn Gly 
        755                 760                 765             


Pro Leu Trp Cys Phe Ile Phe Phe Thr Ala Ala Trp Tyr Leu Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Val Ala Thr Tyr Ser Val Leu Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Leu Leu Leu Val Leu Ala Leu Pro Gln Gln Ala Tyr Ala Leu Asp Ala 
                805                 810                 815     


Ala Glu Gln Gly Glu Leu Gly Leu Ala Ile Leu Val Ile Ile Ser Ile 
            820                 825                 830         


Phe Thr Leu Thr Pro Ala Tyr Lys Ile Leu Leu Ser Arg Ser Val Trp 
        835                 840                 845             


Trp Leu Ser Tyr Met Leu Val Leu Ala Glu Ala Gln Ile Gln Gln Trp 
    850                 855                 860                 


Val Pro Pro Leu Glu Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Val 
865                 870                 875                 880 


Ala Val Ile Leu His Pro Arg Leu Val Phe Glu Val Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Ile Leu Gly Pro Ala Tyr Leu Leu Lys Ala Ser Leu Leu Arg 
            900                 905                 910         


Ile Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Val Cys Thr Leu 
        915                 920                 925             


Val Lys His Leu Ala Gly Ala Arg Tyr Ile Gln Met Leu Leu Ile Thr 
    930                 935                 940                 


Ile Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Ser Pro Leu 
945                 950                 955                 960 


Ser Thr Trp Ala Ala Gln Gly Leu Arg Asp Leu Ala Ile Ala Val Glu 
                965                 970                 975     


Pro Val Val Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Val Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Lys Leu Leu  Ala Pro Ile Thr Ala  Tyr Thr Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Ala Ile Val Val Ser  Leu Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Asn Glu Gln Ala  Gly Gln Val Gln Val  Leu Ser Ser 
    1055                 1060                 1065             


Val Thr  Gln Thr Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Pro Lys 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Thr Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Asp  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Val Arg Arg Lys Asp  Asp Arg Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Ser Arg Gly His Ala  Val Gly Leu Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ala  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Ser Leu  Asp Val Ala Thr Arg  Thr Pro Ser Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Ser Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Ala Ala Tyr 
    1235                 1240                 1245             


Ala Ser  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Met Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Asp 
    1280                 1285                 1290             


Ser Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Ile Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Ala Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ser Val  Asp Ala Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Val Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Thr Val Thr  Thr Pro His Ser Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly His Glu Gly  Glu Ile Pro Phe Tyr  Gly Lys Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ala Phe Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Val Asn Ala Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Ser Gln Ile  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Val Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Ser Gly Glu  Arg Pro Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ala Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Gly Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Thr 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ala Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Ile Met  Thr Ser Ser Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Ile Ser  Ile Ile Gly Arg Leu  His Leu Asn Asp Arg  Val Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Ile Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Lys Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Met 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Thr Arg  Gln Ala Gln Asp Ile  Gln Pro Ala Ile Gln  Ser Ser Trp 
    1745                 1750                 1755             


Pro Lys  Leu Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Pro Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Met Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Ile Leu Val Asp Val  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Thr Val  Glu Asp Val Val Asn  Leu Leu Pro Ala Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Gln Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Val  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Val Leu Ser 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Ala Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Val Pro  Cys Ser Gly Ser Trp  Leu Gln Asp 
    1970                 1975                 1980             


Ile Trp  Asp Trp Val Cys Ser  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Ser  Ser Lys Leu Leu Pro  Lys Met Pro Gly Ile  Pro Phe Ile 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Val 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly His Val 
    2030                 2035                 2040             


Arg Met  Gly Thr Met Lys Ile  Thr Gly Pro Lys Thr  Cys Leu Asn 
    2045                 2050                 2055             


Leu Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Pro 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Pro Pro  Asn Tyr Lys Thr Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Val  Glu Val Thr Gln His  Gly Ser Phe 
    2090                 2095                 2100             


Ser Tyr  Val Thr Gly Leu Thr  Ser Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Val  Pro Ala Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Val  Pro Gly Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Thr  Phe Thr Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Glu Val Leu  Ala Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Ala Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Gln Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Lys Ala Thr Cys Thr  Thr His Lys 
    2210                 2215                 2220             


Thr Ala  Tyr Asp Cys Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Asp Ser Lys Val  Ile Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Ser Met Thr  Glu Val Glu Asp Asp  Arg Glu Pro 
    2255                 2260                 2265             


Ser Val  Pro Ser Glu Tyr Leu  Ile Lys Arg Arg Lys  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Pro Trp Ala Arg  Pro Asp Tyr Asn Pro  Val Leu Ile 
    2285                 2290                 2295             


Glu Thr  Trp Lys Arg Pro Gly  Tyr Glu Pro Pro Thr  Val Leu Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Thr Pro  Gln Thr Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Ala Lys Val Leu  Thr Gln Asp Asn Val  Glu Gly Ile 
    2330                 2335                 2340             


Leu Arg  Glu Met Ala Asp Lys  Val Leu Ser Pro Leu  Gln Asp Asn 
    2345                 2350                 2355             


Asn Asp  Ser Gly His Ser Thr  Gly Ala Asp Thr Gly  Gly Asp Ile 
    2360                 2365                 2370             


Val Gln  Gln Pro Ser Asp Glu  Thr Ala Ala Ser Glu  Ala Gly Ser 
    2375                 2380                 2385             


Leu Ser  Ser Met Pro Pro Leu  Glu Gly Glu Pro Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Phe Glu Pro Val Gly  Ser Ala Pro Pro Ser  Glu Gly Glu 
    2405                 2410                 2415             


Cys Glu  Val Ile Asp Ser Asp  Ser Lys Ser Trp Ser  Thr Val Ser 
    2420                 2425                 2430             


Asp Gln  Glu Asp Ser Val Ile  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Gly Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Met Arg Phe  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Ser Thr Thr Ser Arg  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Val Gln  Val Leu Asp Ala His  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Gln Asp Val Lys Arg  Ala Ala Ser Lys Val  Ser Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Val Glu Glu Ala  Cys Ala Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Lys  Ser Arg Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Arg  Arg Ala Val Asn His  Ile Arg Ser Val Trp  Glu Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Gln His Thr Pro  Ile Asp Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Ile Asp  Pro Thr Lys Gly Gly  Lys Lys Pro 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Ala Gln Lys Leu Pro  Lys Ala Ile 
    2615                 2620                 2625             


Met Gly  Pro Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Glu Arg Val 
    2630                 2635                 2640             


Asp Phe  Leu Leu Lys Ala Trp  Gly Ser Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Gln Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Gln Glu  Ala Arg Thr Val Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Thr Asn  Ser Lys Gly Gln Ser  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Phe Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Met  Thr Cys Tyr Ile Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Val Asp Pro Val Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Asn Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Leu  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Asp Ser Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Phe  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Thr  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Ile Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Leu Ala Gln Asp Thr  Leu Asn Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Ser Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Glu Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Ser  Pro Arg Glu Leu Ser  Arg Val Ala 
    2915                 2920                 2925             


Ala Thr  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ala  Gln Gly Ala 
    2945                 2950                 2955             


Arg Ala  Ala Ile Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Ser  Arg Leu Asp 
    2975                 2980                 2985             


Leu Ser  Gly Trp Phe Thr Val  Gly Ala Gly Gly Gly  Gly Ile Tyr 
    2990                 2995                 3000             


His Ser  Val Ser His Ala Arg  Pro Arg Leu Leu Leu  Leu Cys Leu 
    3005                 3010                 3015             


Leu Leu  Leu Ser Val Gly Val  Gly Ile Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  117
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  117

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Arg Val Ile Asp Thr Ile Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Val Thr Val Pro Val Ser Ala Val 
            180                 185                 190         


Glu Val Arg Asn Ile Ser Ser Ser Tyr Tyr Ala Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Asn Ser Ile Thr Trp Gln Leu Thr Asp Ala Val Leu His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Asn Asp Asn Gly Thr Leu His Cys Trp Ile 
225                 230                 235                 240 


Gln Val Thr Pro Asn Val Ala Val Lys His Arg Gly Ala Leu Thr Arg 
                245                 250                 255     


Ser Leu Arg Thr His Val Asp Met Ile Val Met Ala Ala Thr Ala Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Val Cys Gly Ala Val Met Ile Leu Ser 
        275                 280                 285             


Gln Ala Phe Met Val Ser Pro Gln Arg His Asn Phe Thr Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Gln Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Leu Asn Trp Ser Pro Thr Leu Ala Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Ala Arg Val Pro Glu Met Val Leu Glu Ile Ile Phe Gly Gly His 
            340                 345                 350         


Trp Gly Val Val Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Ile Ala Ile Leu Leu Leu Val Ala Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr Tyr Ser Ser Gly Gln Glu Ala Gly Arg Thr Val Leu Gly Phe Thr 
385                 390                 395                 400 


Asn Leu Phe Thr Ser Gly Ala Lys Gln Asn Leu Tyr Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Met Ala Ser Leu Phe Tyr Thr His Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ser Ser Cys Arg Gly Leu Asp Asp 
    450                 455                 460                 


Phe Arg Ile Gly Trp Gly Thr Leu Glu Tyr Glu Thr His Val Thr Asn 
465                 470                 475                 480 


Asp Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys 
                485                 490                 495     


Gly Ile Val Pro Ala Arg Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Lys Gln Gly Val Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Arg Gly Ala Trp Phe Gly Cys Thr Trp Met Asn Gly Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Lys Asp 
                565                 570                 575     


Tyr Asn Ser Thr Ile Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Ala Thr Tyr Leu Lys Cys Gly Ala Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile Phe Lys Ala Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Phe Ser Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Arg Leu Glu Asp Arg Asp Arg Gly Gln Gln Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Val Leu Pro Cys Ser Phe Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Leu Thr Arg Tyr Ile Val Lys Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Ile Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Ile Ile Leu His Ser Ala Ser Ala Ala Ser Ala Asn Gly 
        755                 760                 765             


Pro Leu Trp Cys Phe Ile Phe Phe Thr Ala Ala Trp Tyr Leu Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Val Ala Thr Tyr Ser Val Leu Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Leu Leu Leu Val Leu Ala Leu Pro Gln Gln Ala Tyr Ala Leu Asp Ala 
                805                 810                 815     


Ala Glu Gln Gly Glu Leu Gly Leu Ala Ile Leu Val Ile Ile Ser Ile 
            820                 825                 830         


Phe Thr Leu Thr Pro Ala Tyr Lys Ile Leu Leu Ser Arg Ser Val Trp 
        835                 840                 845             


Trp Leu Ser Tyr Met Leu Val Leu Ala Glu Ala Gln Ile Gln Gln Trp 
    850                 855                 860                 


Val Pro Pro Leu Glu Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Val 
865                 870                 875                 880 


Ala Val Ile Leu His Pro Arg Leu Val Phe Glu Val Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Ile Leu Gly Pro Ala Tyr Leu Leu Lys Ala Ser Leu Leu Arg 
            900                 905                 910         


Ile Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Val Cys Thr Leu 
        915                 920                 925             


Val Lys His Leu Ala Gly Ala Arg Tyr Ile Gln Met Leu Leu Ile Thr 
    930                 935                 940                 


Ile Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Ser Pro Leu 
945                 950                 955                 960 


Ser Thr Trp Ala Ala Gln Gly Leu Arg Asp Leu Ala Ile Ala Val Glu 
                965                 970                 975     


Pro Val Val Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Val Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Lys Leu Leu  Ala Pro Ile Thr Ala  Tyr Thr Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Ala Ile Val Val Ser  Leu Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Asn Glu Gln Ala  Gly Gln Val Gln Val  Leu Ser Ser 
    1055                 1060                 1065             


Val Thr  Gln Thr Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Pro Lys 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Thr Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Asp  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Val Arg Arg Lys Asp  Asp Arg Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Ser Arg Gly His Ala  Val Gly Leu Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ala  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Ser Leu  Asp Val Thr Thr Arg  Thr Pro Ser Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Ser Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Ala Ala Tyr 
    1235                 1240                 1245             


Ala Ser  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Met Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Asp 
    1280                 1285                 1290             


Ser Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Ile Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Ala Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ser Val  Asp Ala Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Val Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Thr Val Thr  Thr Pro His Ser Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly His Glu Gly  Glu Ile Pro Phe Tyr  Gly Lys Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ala Phe Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Val Asn Ala Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Ser Gln Ile  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Val Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Ser Gly Glu  Arg Pro Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ala Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Gly Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Thr 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ala Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Ile Met  Thr Ser Ser Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Ile Ser  Ile Ile Gly Arg Leu  His Leu Asn Asp Arg  Val Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Ile Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Lys Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Met 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Thr Arg  Gln Ala Gln Asp Ile  Gln Pro Ala Ile Gln  Ser Ser Trp 
    1745                 1750                 1755             


Pro Lys  Leu Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Pro Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Met Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Ile Leu Val Asp Val  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Thr Val  Glu Asp Val Val Asn  Leu Leu Pro Ala Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Gln Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Val  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Val Leu Ser 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Ala Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Val Pro  Cys Ser Gly Ser Trp  Leu Gln Asp 
    1970                 1975                 1980             


Ile Trp  Asp Trp Val Cys Ser  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Ser  Ser Lys Leu Leu Pro  Lys Met Pro Gly Ile  Pro Phe Ile 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Val 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly His Val 
    2030                 2035                 2040             


Arg Met  Gly Thr Met Lys Ile  Thr Gly Pro Lys Thr  Cys Leu Asn 
    2045                 2050                 2055             


Leu Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Pro 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Pro Pro  Asn Tyr Lys Thr Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Val  Glu Val Thr Gln His  Gly Ser Phe 
    2090                 2095                 2100             


Ser Tyr  Val Thr Gly Leu Thr  Ser Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Val  Pro Ala Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Val  Pro Gly Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Thr  Phe Thr Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Glu Val Leu  Ala Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Ala Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Gln Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Lys Ala Thr Cys Thr  Thr His Lys 
    2210                 2215                 2220             


Thr Ala  Tyr Asp Cys Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Asp Ser Lys Val  Ile Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Ser Met Thr  Glu Val Glu Asp Asp  Arg Glu Pro 
    2255                 2260                 2265             


Ser Val  Pro Ser Glu Tyr Leu  Ile Lys Arg Arg Lys  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Pro Trp Ala Arg  Pro Asp Tyr Asn Pro  Val Leu Ile 
    2285                 2290                 2295             


Glu Thr  Trp Lys Arg Pro Gly  Tyr Glu Pro Pro Thr  Val Leu Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Thr Pro  Gln Thr Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Ala Lys Val Leu  Thr Gln Asp Asn Val  Glu Gly Ile 
    2330                 2335                 2340             


Leu Arg  Glu Met Ala Asp Lys  Val Leu Ser Pro Leu  Gln Asp Asn 
    2345                 2350                 2355             


Asn Asp  Ser Gly His Ser Thr  Gly Ala Asp Thr Gly  Gly Asp Ile 
    2360                 2365                 2370             


Val Gln  Gln Pro Ser Asp Glu  Thr Ala Ala Ser Glu  Ala Gly Ser 
    2375                 2380                 2385             


Leu Ser  Ser Met Pro Pro Leu  Glu Gly Glu Pro Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Phe Glu Pro Val Gly  Ser Ala Pro Pro Ser  Glu Gly Glu 
    2405                 2410                 2415             


Cys Glu  Val Ile Asp Ser Asp  Ser Lys Ser Trp Ser  Thr Val Ser 
    2420                 2425                 2430             


Asp Gln  Glu Asp Ser Val Ile  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Gly Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Met Arg Phe  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Ser Thr Thr Ser Arg  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Val Gln  Val Leu Asp Ala His  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Gln Asp Val Lys Arg  Ala Ala Ser Lys Val  Ser Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Val Glu Glu Ala  Cys Ala Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Lys  Ser Arg Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Arg  Arg Ala Val Asn His  Ile Arg Ser Val Trp  Glu Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Gln His Thr Pro  Ile Asp Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Ile Asp  Pro Thr Lys Gly Gly  Lys Lys Pro 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Ala Gln Lys Leu Pro  Lys Ala Ile 
    2615                 2620                 2625             


Met Gly  Pro Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Glu Arg Val 
    2630                 2635                 2640             


Asp Phe  Leu Leu Lys Ala Trp  Gly Ser Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Gln Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Gln Glu  Ala Arg Thr Val Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Thr Asn  Ser Lys Gly Gln Ser  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Phe Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Met  Thr Cys Tyr Ile Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Val Asp Pro Val Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Asn Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Leu  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Asp Ser Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Phe  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Thr  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Ile Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Leu Ala Gln Asp Thr  Leu Asn Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Asn Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Glu Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Ser  Pro Arg Glu Leu Ser  Arg Val Ala 
    2915                 2920                 2925             


Ala Thr  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ala  Gln Gly Ala 
    2945                 2950                 2955             


Arg Ala  Ala Ile Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Ser  Arg Leu Asp 
    2975                 2980                 2985             


Leu Ser  Gly Trp Phe Thr Val  Gly Ala Gly Gly Gly  Gly Ile Tyr 
    2990                 2995                 3000             


His Ser  Val Ser His Ala Arg  Pro Arg Leu Leu Leu  Leu Cys Leu 
    3005                 3010                 3015             


Leu Leu  Leu Ser Val Gly Val  Gly Ile Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  118
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  118

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Arg Val Ile Asp Thr Ile Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Val Thr Val Pro Val Ser Ala Val 
            180                 185                 190         


Glu Val Arg Asn Ile Ser Ser Ser Tyr Tyr Ala Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Asn Ser Ile Thr Trp Gln Leu Thr Asp Ala Val Leu His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Asn Asp Asn Gly Thr Leu His Cys Trp Ile 
225                 230                 235                 240 


Gln Val Thr Pro Asn Val Ala Val Lys His Arg Gly Ala Leu Thr Arg 
                245                 250                 255     


Ser Leu Arg Thr His Val Asp Met Ile Val Met Ala Ala Thr Ala Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Val Cys Gly Ala Val Met Ile Leu Ser 
        275                 280                 285             


Gln Ala Phe Met Val Ser Pro Gln Arg His Asn Phe Thr Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Gln Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Leu Asn Trp Ser Pro Thr Leu Ala Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Ala Arg Val Pro Glu Met Val Leu Glu Ile Ile Phe Gly Gly His 
            340                 345                 350         


Trp Gly Val Val Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Ile Ala Ile Leu Leu Leu Val Ala Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr Tyr Ser Ser Gly Gln Glu Ala Gly Arg Thr Val Leu Gly Phe Thr 
385                 390                 395                 400 


Asn Leu Phe Thr Ser Gly Ala Lys Gln Asn Leu Tyr Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Met Ala Ser Leu Phe Tyr Thr His Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ser Ser Cys Arg Gly Leu Asp Asp 
    450                 455                 460                 


Phe Arg Ile Gly Trp Gly Thr Leu Glu Tyr Glu Thr His Val Thr Asn 
465                 470                 475                 480 


Asp Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys 
                485                 490                 495     


Gly Ile Val Pro Ala Arg Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Lys Gln Gly Val Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Arg Gly Ala Trp Phe Gly Cys Thr Trp Met Asn Gly Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Lys Asp 
                565                 570                 575     


Tyr Asn Ser Thr Ile Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Ala Thr Tyr Leu Lys Cys Gly Ala Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile Phe Lys Ala Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Phe Ser Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Arg Leu Glu Asp Arg Asp Arg Gly Gln Gln Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Val Leu Pro Cys Ser Phe Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Leu Thr Arg Tyr Ile Val Lys Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Ile Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Ile Ile Leu His Ser Ala Ser Ala Ala Ser Ala Asn Gly 
        755                 760                 765             


Pro Leu Trp Cys Phe Ile Phe Phe Thr Ala Ala Trp Tyr Leu Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Val Ala Thr Tyr Ser Val Leu Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Leu Leu Leu Val Leu Ala Leu Pro Gln Gln Ala Tyr Ala Leu Asp Ala 
                805                 810                 815     


Ala Glu Gln Gly Glu Leu Gly Leu Ala Ile Leu Val Ile Ile Ser Ile 
            820                 825                 830         


Phe Thr Leu Thr Pro Ala Tyr Lys Ile Leu Leu Ser Arg Ser Val Trp 
        835                 840                 845             


Trp Leu Ser Tyr Met Leu Val Leu Ala Glu Ala Gln Ile Gln Gln Arg 
    850                 855                 860                 


Val Pro Pro Leu Glu Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Val 
865                 870                 875                 880 


Ala Val Ile Leu His Pro Arg Leu Val Phe Glu Val Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Ile Leu Gly Pro Ala Tyr Leu Leu Lys Ala Ser Leu Leu Arg 
            900                 905                 910         


Ile Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Val Cys Thr Leu 
        915                 920                 925             


Val Lys His Leu Ala Gly Ala Arg Tyr Ile Gln Met Leu Leu Ile Thr 
    930                 935                 940                 


Ile Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Ser Pro Leu 
945                 950                 955                 960 


Ser Thr Trp Ala Ala Gln Gly Leu Arg Asp Leu Ala Ile Ala Val Glu 
                965                 970                 975     


Pro Val Val Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Val Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Lys Leu Leu  Ala Pro Ile Thr Ala  Tyr Thr Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Ala Ile Val Val Ser  Leu Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Asn Glu Gln Ala  Gly Gln Val Gln Val  Leu Ser Ser 
    1055                 1060                 1065             


Val Thr  Gln Thr Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Pro Lys 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Thr Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Asp  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Val Arg Arg Lys Asp  Asp Arg Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Ser Arg Gly His Ala  Val Gly Leu Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ala  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Ser Leu  Asp Val Ala Thr Arg  Thr Pro Ser Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Ser Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Ala Ala Tyr 
    1235                 1240                 1245             


Ala Ser  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Met Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Asp 
    1280                 1285                 1290             


Ser Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Ile Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Ala Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ser Val  Asp Ala Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Val Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Thr Val Thr  Thr Pro His Ser Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly His Glu Gly  Glu Ile Pro Phe Tyr  Gly Lys Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ala Phe Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Val Asn Ala Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Ser Gln Ile  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Val Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Ser Gly Glu  Arg Pro Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ala Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Gly Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Thr 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ala Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Ile Met  Thr Ser Ser Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Ile Ser  Ile Ile Gly Arg Leu  His Leu Asn Asp Arg  Val Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Ile Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Lys Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Met 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Thr Arg  Gln Ala Gln Asp Ile  Gln Pro Ala Ile Gln  Ser Ser Trp 
    1745                 1750                 1755             


Pro Lys  Leu Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Pro Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Met Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Ile Leu Val Asp Val  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Thr Val  Glu Asp Val Val Asn  Leu Leu Pro Ala Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Gln Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Val  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Val Leu Ser 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Ala Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Val Pro  Cys Ser Gly Ser Trp  Leu Gln Asp 
    1970                 1975                 1980             


Ile Trp  Asp Trp Val Cys Ser  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Ser  Ser Lys Leu Leu Pro  Lys Met Pro Gly Ile  Pro Phe Ile 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Val 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly His Val 
    2030                 2035                 2040             


Arg Met  Gly Thr Met Lys Ile  Thr Gly Pro Lys Thr  Cys Leu Asn 
    2045                 2050                 2055             


Leu Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Pro 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Pro Pro  Asn Tyr Lys Thr Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Val  Glu Val Thr Gln His  Gly Ser Phe 
    2090                 2095                 2100             


Ser Tyr  Val Thr Gly Leu Thr  Ser Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Val  Pro Ala Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Val  Pro Gly Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Thr  Phe Thr Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Glu Val Leu  Ala Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Ala Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Gln Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Lys Ala Thr Cys Thr  Thr His Lys 
    2210                 2215                 2220             


Thr Ala  Tyr Asp Cys Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Asp Ser Lys Val  Ile Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Ser Met Thr  Glu Val Glu Asp Asp  Arg Glu Pro 
    2255                 2260                 2265             


Ser Val  Pro Ser Glu Tyr Leu  Ile Lys Arg Arg Lys  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Pro Trp Ala Arg  Pro Asp Tyr Asn Pro  Val Leu Ile 
    2285                 2290                 2295             


Glu Thr  Trp Lys Arg Pro Gly  Tyr Glu Pro Pro Thr  Val Leu Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Thr Pro  Gln Thr Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Ala Lys Val Leu  Thr Gln Asp Asn Val  Glu Gly Ile 
    2330                 2335                 2340             


Leu Arg  Glu Met Ala Asp Lys  Val Leu Ser Pro Leu  Gln Asp Asn 
    2345                 2350                 2355             


Asn Asp  Ser Gly His Ser Thr  Gly Ala Asp Thr Gly  Gly Asp Ile 
    2360                 2365                 2370             


Val Gln  Gln Pro Ser Asp Glu  Thr Ala Ala Ser Glu  Ala Gly Ser 
    2375                 2380                 2385             


Leu Ser  Ser Met Pro Pro Leu  Glu Gly Glu Pro Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Phe Glu Pro Val Gly  Ser Ala Pro Pro Ser  Glu Gly Glu 
    2405                 2410                 2415             


Cys Glu  Val Ile Asp Ser Asp  Ser Lys Ser Trp Ser  Thr Val Ser 
    2420                 2425                 2430             


Asp Gln  Glu Asp Ser Val Ile  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Gly Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Met Arg Phe  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Ser Thr Thr Ser Arg  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Val Gln  Val Leu Asp Ala His  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Gln Asp Val Lys Arg  Ala Ala Ser Lys Val  Ser Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Val Glu Glu Ala  Cys Ala Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Lys  Ser Arg Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Arg  Arg Ala Val Asn His  Ile Arg Ser Val Trp  Glu Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Gln His Thr Pro  Ile Asp Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Ile Asp  Pro Thr Lys Gly Gly  Lys Lys Pro 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Ala Gln Lys Leu Pro  Lys Ala Ile 
    2615                 2620                 2625             


Met Gly  Pro Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Glu Arg Val 
    2630                 2635                 2640             


Asp Phe  Leu Leu Lys Ala Trp  Gly Ser Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Gln Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Gln Glu  Ala Arg Thr Val Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Thr Asn  Ser Lys Gly Gln Ser  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Phe Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Met  Thr Cys Tyr Ile Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Val Asp Pro Val Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Asn Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Leu  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Asp Ser Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Phe  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Thr  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Ile Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Leu Ala Gln Asp Thr  Leu Asn Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Asn Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Glu Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Ser  Pro Arg Glu Leu Ser  Arg Val Ala 
    2915                 2920                 2925             


Ala Thr  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ala  Gln Gly Ala 
    2945                 2950                 2955             


Arg Ala  Ala Ile Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Ser  Arg Leu Asp 
    2975                 2980                 2985             


Leu Ser  Gly Trp Phe Thr Val  Gly Ala Gly Gly Gly  Gly Ile Tyr 
    2990                 2995                 3000             


His Ser  Val Ser His Ala Arg  Pro Arg Leu Leu Leu  Leu Cys Leu 
    3005                 3010                 3015             


Leu Leu  Leu Ser Val Gly Val  Gly Ile Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  119
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  119

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Arg Val Ile Asp Thr Ile Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Val Thr Val Pro Val Ser Ala Val 
            180                 185                 190         


Glu Val Arg Asn Ile Ser Ser Ser Tyr Tyr Ala Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Asn Ser Ile Thr Trp Gln Leu Thr Asp Ala Val Leu His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Asn Asp Asn Gly Thr Leu His Cys Trp Ile 
225                 230                 235                 240 


Gln Val Thr Pro Asn Val Ala Val Lys His Arg Gly Ala Leu Thr Arg 
                245                 250                 255     


Ser Leu Arg Thr His Val Asp Met Ile Val Met Ala Ala Thr Ala Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Val Cys Gly Ala Val Met Ile Leu Ser 
        275                 280                 285             


Gln Ala Phe Met Val Ser Pro Gln Arg His Asn Phe Thr Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Gln Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Leu Asn Trp Ser Pro Thr Leu Ala Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Ala Arg Val Pro Glu Met Val Leu Glu Ile Ile Phe Gly Gly His 
            340                 345                 350         


Trp Gly Val Val Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Ile Ala Ile Leu Leu Leu Val Ala Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr Tyr Ser Ser Gly Gln Glu Ala Gly Arg Thr Val Leu Gly Phe Thr 
385                 390                 395                 400 


Asn Leu Phe Thr Ser Gly Ala Lys Gln Asn Leu Tyr Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Met Ala Ser Leu Phe Tyr Thr His Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ser Ser Cys Arg Gly Leu Asp Asp 
    450                 455                 460                 


Phe Arg Ile Gly Trp Gly Thr Leu Glu Tyr Glu Thr His Val Thr Asn 
465                 470                 475                 480 


Asp Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys 
                485                 490                 495     


Gly Ile Val Pro Ala Arg Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Lys Gln Gly Val Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Arg Gly Ala Trp Phe Gly Cys Thr Trp Met Asn Gly Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Lys Asp 
                565                 570                 575     


Tyr Asn Ser Thr Ile Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Ala Thr Tyr Leu Lys Cys Gly Ala Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile Phe Lys Ala Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Phe Ser Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Arg Leu Glu Asp Arg Asp Arg Gly Gln Gln Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Val Leu Pro Cys Ser Phe Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Leu Thr Arg Tyr Ile Val Lys Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Ile Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Ile Ile Leu His Ser Ala Ser Ala Ala Ser Ala Asn Gly 
        755                 760                 765             


Pro Leu Trp Cys Phe Ile Phe Phe Thr Ala Ala Trp Tyr Leu Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Val Ala Thr Tyr Ser Val Leu Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Leu Leu Leu Val Leu Ala Leu Pro Gln Gln Ala Tyr Ala Leu Asp Ala 
                805                 810                 815     


Ala Glu Gln Gly Glu Leu Gly Leu Ala Ile Leu Val Ile Ile Ser Ile 
            820                 825                 830         


Phe Thr Leu Thr Pro Ala Tyr Lys Ile Leu Leu Ser Arg Ser Val Trp 
        835                 840                 845             


Trp Leu Ser Tyr Met Leu Val Leu Ala Glu Ala Gln Ile Gln Gln Trp 
    850                 855                 860                 


Val Pro Pro Leu Glu Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Val 
865                 870                 875                 880 


Ala Val Ile Leu His Pro Arg Leu Val Phe Glu Val Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Ile Leu Gly Pro Ala Tyr Leu Leu Lys Ala Ser Leu Leu Arg 
            900                 905                 910         


Ile Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Val Cys Thr Leu 
        915                 920                 925             


Val Lys His Leu Ala Gly Ala Arg Tyr Ile Gln Met Leu Leu Ile Thr 
    930                 935                 940                 


Ile Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Ser Pro Leu 
945                 950                 955                 960 


Ser Thr Trp Ala Ala Gln Gly Leu Arg Asp Leu Ala Ile Ala Val Glu 
                965                 970                 975     


Pro Val Val Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Val Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Lys Leu Leu  Ala Pro Ile Thr Ala  Tyr Thr Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Ala Ile Val Val Ser  Leu Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Asn Glu Gln Ala  Gly Gln Val Gln Val  Leu Ser Ser 
    1055                 1060                 1065             


Val Thr  Gln Thr Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Pro Lys 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Thr Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Asp  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Val Arg Arg Lys Asp  Asp Arg Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Ser Arg Gly His Ala  Val Gly Leu Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ala  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Ser Leu  Asp Val Thr Thr Arg  Thr Pro Ser Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Ser Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Ala Ala Tyr 
    1235                 1240                 1245             


Ala Ser  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Met Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Asp 
    1280                 1285                 1290             


Ser Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Ile Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Ala Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ser Val  Asp Ala Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Val Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Thr Val Thr  Thr Pro His Ser Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly His Glu Gly  Glu Ile Pro Phe Tyr  Gly Lys Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ala Phe Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Val Asn Ala Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Ser Gln Ile  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Val Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Ser Gly Glu  Arg Pro Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ala Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Gly Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Thr 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ala Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Ile Met  Thr Ser Ser Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Ile Ser  Ile Ile Gly Arg Leu  His Leu Asn Asp Arg  Val Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Ile Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Lys Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Met 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Thr Arg  Gln Ala Gln Asp Ile  Gln Pro Ala Ile Gln  Ser Ser Trp 
    1745                 1750                 1755             


Pro Lys  Leu Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Pro Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Met Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Ile Leu Val Asp Val  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Thr Val  Glu Asp Val Val Asn  Leu Leu Pro Ala Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Gln Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Val  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Val Leu Ser 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Ala Trp Val 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Val Pro  Cys Ser Gly Ser Trp  Leu Gln Asp 
    1970                 1975                 1980             


Ile Trp  Asp Trp Val Cys Ser  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Ser  Ser Lys Leu Leu Pro  Lys Met Pro Gly Ile  Pro Phe Ile 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Val 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly His Val 
    2030                 2035                 2040             


Arg Met  Gly Thr Met Lys Ile  Thr Gly Pro Lys Thr  Cys Leu Asn 
    2045                 2050                 2055             


Leu Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Pro 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Pro Pro  Asn Tyr Lys Thr Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Val  Glu Val Thr Gln His  Gly Ser Phe 
    2090                 2095                 2100             


Ser Tyr  Val Thr Gly Leu Thr  Ser Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Val  Pro Ala Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Val  Pro Gly Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Thr  Phe Thr Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Glu Val Leu  Ala Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Ala Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Gln Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Lys Ala Thr Cys Thr  Thr His Lys 
    2210                 2215                 2220             


Thr Ala  Tyr Asp Cys Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Asp Ser Lys Val  Ile Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Ser Met Thr  Glu Val Glu Asp Asp  Arg Glu Pro 
    2255                 2260                 2265             


Ser Val  Pro Ser Glu Tyr Leu  Ile Lys Arg Arg Lys  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Pro Trp Ala Arg  Pro Asp Tyr Asn Pro  Val Leu Ile 
    2285                 2290                 2295             


Glu Thr  Trp Lys Arg Pro Gly  Tyr Glu Pro Pro Thr  Val Leu Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Thr Pro  Gln Thr Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Ala Lys Val Leu  Thr Gln Asp Asn Val  Glu Gly Ile 
    2330                 2335                 2340             


Leu Arg  Glu Met Ala Asp Lys  Val Leu Ser Pro Leu  Gln Asp Asn 
    2345                 2350                 2355             


Asn Asp  Ser Gly His Ser Thr  Gly Ala Asp Thr Gly  Gly Asp Ile 
    2360                 2365                 2370             


Val Gln  Gln Pro Ser Asp Glu  Thr Ala Ala Ser Glu  Ala Gly Ser 
    2375                 2380                 2385             


Leu Ser  Ser Met Pro Pro Leu  Glu Gly Glu Pro Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Phe Glu Pro Val Gly  Ser Ala Pro Pro Ser  Glu Gly Glu 
    2405                 2410                 2415             


Cys Glu  Val Ile Asp Ser Asp  Ser Lys Ser Trp Ser  Thr Val Ser 
    2420                 2425                 2430             


Asp Gln  Glu Asp Ser Val Ile  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Gly Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Met Arg Phe  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Ser Thr Thr Ser Arg  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Val Gln  Val Leu Asp Ala His  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Gln Asp Val Lys Arg  Ala Ala Ser Lys Val  Ser Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Val Glu Glu Ala  Cys Ala Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Lys  Ser Arg Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Arg  Arg Ala Val Asn His  Ile Arg Ser Val Trp  Glu Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Gln His Thr Pro  Ile Asp Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Ile Asp  Pro Thr Lys Gly Gly  Lys Lys Pro 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Ala Gln Lys Leu Pro  Lys Ala Ile 
    2615                 2620                 2625             


Met Gly  Pro Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Glu Arg Val 
    2630                 2635                 2640             


Asp Phe  Leu Leu Lys Ala Trp  Gly Ser Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Gln Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Gln Glu  Ala Arg Thr Val Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Thr Asn  Ser Lys Gly Gln Ser  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Phe Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Met  Thr Cys Tyr Ile Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Val Asp Pro Val Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Asn Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Leu  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Asp Ser Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Phe  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Thr  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Ile Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Leu Ala Gln Asp Thr  Leu Asn Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Asn Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Glu Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Ser  Pro Arg Glu Leu Ser  Arg Val Ala 
    2915                 2920                 2925             


Ala Thr  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ala  Gln Gly Ala 
    2945                 2950                 2955             


Arg Ala  Ala Ile Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Ser  Arg Leu Asp 
    2975                 2980                 2985             


Leu Ser  Gly Trp Phe Thr Val  Gly Ala Gly Gly Gly  Gly Ile Tyr 
    2990                 2995                 3000             


His Ser  Val Ser His Ala Arg  Pro Arg Leu Leu Leu  Leu Cys Leu 
    3005                 3010                 3015             


Leu Leu  Leu Ser Val Gly Val  Gly Ile Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  120
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  120

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Arg Val Ile Asp Thr Ile Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Val Thr Val Pro Val Ser Ala Val 
            180                 185                 190         


Glu Val Arg Asn Ile Ser Ser Ser Tyr Tyr Ala Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Asn Ser Ile Thr Trp Gln Leu Thr Asp Ala Val Leu His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Asn Asp Asn Gly Thr Leu His Cys Trp Ile 
225                 230                 235                 240 


Gln Val Thr Pro Asn Val Ala Val Lys His Arg Gly Ala Leu Thr Arg 
                245                 250                 255     


Ser Leu Arg Thr His Val Asp Met Ile Val Met Ala Ala Thr Ala Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Val Cys Gly Ala Val Met Ile Leu Ser 
        275                 280                 285             


Gln Ala Phe Met Val Ser Pro Gln Arg His Asn Phe Thr Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Gln Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Leu Asn Trp Ser Pro Thr Leu Ala Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Ala Arg Val Pro Glu Met Val Leu Glu Ile Ile Phe Gly Gly His 
            340                 345                 350         


Trp Gly Val Val Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Ile Ala Ile Leu Leu Leu Val Ala Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr Tyr Ser Ser Gly Gln Glu Ala Gly Arg Thr Val Leu Gly Phe Thr 
385                 390                 395                 400 


Asn Leu Phe Thr Ser Gly Ala Lys Gln Asn Leu Tyr Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Met Ala Ser Leu Phe Tyr Thr His Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ser Ser Cys Arg Gly Leu Asp Asp 
    450                 455                 460                 


Phe Arg Ile Gly Trp Gly Thr Leu Glu Tyr Glu Thr His Val Thr Asn 
465                 470                 475                 480 


Asp Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys 
                485                 490                 495     


Gly Ile Val Pro Ala Arg Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Lys Gln Gly Val Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Arg Gly Ala Trp Phe Gly Cys Thr Trp Met Asn Gly Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Lys Asp 
                565                 570                 575     


Tyr Asn Ser Thr Ile Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Ala Thr Tyr Leu Lys Cys Gly Ala Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile Phe Lys Ala Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Phe Ser Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Arg Leu Glu Asp Arg Asp Arg Gly Gln Gln Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Val Leu Pro Cys Ser Phe Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Leu Thr Arg Tyr Ile Val Lys Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Ile Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Ile Ile Leu His Ser Ala Ser Ala Ala Ser Ala Asn Gly 
        755                 760                 765             


Pro Leu Trp Cys Phe Ile Phe Phe Thr Ala Ala Trp Tyr Leu Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Val Ala Thr Tyr Ser Val Leu Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Leu Leu Leu Val Leu Ala Leu Pro Gln Gln Ala Tyr Ala Leu Asp Ala 
                805                 810                 815     


Ala Glu Gln Gly Glu Leu Gly Leu Ala Ile Leu Val Ile Ile Ser Ile 
            820                 825                 830         


Phe Thr Leu Thr Pro Ala Tyr Lys Ile Leu Leu Ser Arg Ser Val Trp 
        835                 840                 845             


Trp Leu Ser Tyr Met Leu Val Leu Ala Glu Ala Gln Ile Gln Gln Trp 
    850                 855                 860                 


Val Pro Pro Leu Glu Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Val 
865                 870                 875                 880 


Ala Val Ile Leu His Pro Arg Leu Val Phe Glu Val Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Ile Leu Gly Pro Ala Tyr Leu Leu Lys Ala Ser Leu Leu Arg 
            900                 905                 910         


Ile Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Val Cys Thr Leu 
        915                 920                 925             


Val Lys His Leu Ala Gly Ala Arg Tyr Ile Gln Met Leu Leu Ile Thr 
    930                 935                 940                 


Ile Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Ser Pro Leu 
945                 950                 955                 960 


Ser Thr Trp Ala Ala Gln Gly Leu Arg Asp Leu Ala Ile Ala Val Glu 
                965                 970                 975     


Pro Val Val Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Val Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Lys Leu Leu  Ala Pro Ile Thr Ala  Tyr Thr Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Ala Ile Val Val Ser  Leu Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Asn Glu Gln Ala  Gly Gln Val Gln Val  Leu Ser Ser 
    1055                 1060                 1065             


Val Thr  Gln Thr Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Pro Lys 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Thr Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Asp  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Val Arg Arg Lys Asp  Asp Arg Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Ser Arg Gly His Ala  Val Gly Leu Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ala  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Ser Leu  Asp Val Thr Thr Arg  Thr Pro Ser Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Ser Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Ala Ala Tyr 
    1235                 1240                 1245             


Ala Ser  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Met Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Asp 
    1280                 1285                 1290             


Ser Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Ile Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Ala Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ser Val  Asp Ala Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Val Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Thr Val Thr  Thr Pro His Ser Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly His Glu Gly  Glu Ile Pro Phe Tyr  Gly Lys Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ala Phe Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Val Asn Ala Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Ser Gln Ile  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Val Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Ser Gly Glu  Arg Pro Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ala Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Gly Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Thr 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ala Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Ile Met  Thr Ser Ser Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Ile Ser  Ile Ile Gly Arg Leu  His Leu Asn Asp Arg  Val Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Ile Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Lys Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Met 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Thr Arg  Gln Ala Gln Asp Ile  Gln Pro Ala Ile Gln  Ser Ser Trp 
    1745                 1750                 1755             


Pro Lys  Leu Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Pro Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Met Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Ile Leu Val Asp Val  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Thr Val  Glu Asp Val Val Asn  Leu Leu Pro Ala Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Gln Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Val  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Val Leu Ser 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Ala Trp Val 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Val Pro  Cys Ser Gly Ser Trp  Leu Gln Asp 
    1970                 1975                 1980             


Ile Trp  Asp Trp Val Cys Ser  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Ser  Ser Lys Leu Leu Pro  Lys Met Pro Gly Ile  Pro Phe Ile 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Val 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly His Val 
    2030                 2035                 2040             


Arg Met  Gly Thr Met Lys Ile  Thr Gly Pro Lys Thr  Cys Leu Asn 
    2045                 2050                 2055             


Leu Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Pro 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Pro Pro  Asn Tyr Lys Thr Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Val  Glu Val Thr Gln His  Gly Ser Phe 
    2090                 2095                 2100             


Ser Tyr  Val Thr Gly Leu Thr  Ser Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Val  Pro Ala Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Val  Pro Gly Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Thr  Phe Thr Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Glu Val Leu  Ala Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Ala Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Gln Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Lys Ala Thr Cys Thr  Thr His Lys 
    2210                 2215                 2220             


Thr Ala  Tyr Asp Cys Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Asp Ser Lys Val  Ile Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Ser Met Thr  Glu Val Glu Asp Asp  Arg Glu Pro 
    2255                 2260                 2265             


Ser Val  Pro Ser Glu Tyr Leu  Ile Lys Arg Arg Lys  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Pro Trp Ala Arg  Pro Asp Tyr Asn Pro  Val Leu Ile 
    2285                 2290                 2295             


Glu Thr  Trp Lys Arg Pro Gly  Tyr Glu Pro Pro Thr  Val Leu Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Thr Pro  Gln Thr Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Ala Lys Val Leu  Thr Gln Asp Asn Val  Glu Gly Ile 
    2330                 2335                 2340             


Leu Arg  Glu Met Ala Asp Lys  Val Leu Ser Pro Leu  Gln Asp Asn 
    2345                 2350                 2355             


Asn Asp  Ser Gly His Ser Thr  Gly Ala Asp Thr Gly  Gly Asp Ile 
    2360                 2365                 2370             


Val Gln  Gln Pro Ser Asp Glu  Thr Ala Ala Ser Glu  Ala Gly Ser 
    2375                 2380                 2385             


Leu Ser  Ser Met Pro Pro Leu  Glu Gly Glu Pro Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Phe Glu Pro Val Gly  Ser Ala Pro Pro Ser  Glu Gly Glu 
    2405                 2410                 2415             


Cys Glu  Val Ile Asp Ser Asp  Ser Lys Ser Trp Ser  Thr Val Ser 
    2420                 2425                 2430             


Asp Gln  Glu Asp Ser Val Ile  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Gly Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Met Arg Phe  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Ser Thr Thr Ser Arg  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Val Gln  Val Leu Asp Ala His  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Gln Asp Val Lys Arg  Ala Ala Ser Lys Val  Ser Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Val Glu Glu Ala  Cys Ala Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Lys  Ser Arg Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Arg  Arg Ala Val Asn His  Ile Arg Ser Val Trp  Glu Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Gln His Thr Pro  Ile Asp Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Ile Asp  Pro Thr Lys Gly Gly  Lys Lys Pro 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Ala Gln Lys Leu Pro  Lys Ala Ile 
    2615                 2620                 2625             


Met Gly  Pro Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Glu Arg Val 
    2630                 2635                 2640             


Asp Phe  Leu Leu Lys Ala Trp  Gly Ser Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Gln Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Gln Glu  Ala Arg Thr Val Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Thr Asn  Ser Lys Gly Gln Ser  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Phe Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Met  Thr Cys Tyr Ile Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Val Asp Pro Val Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Asn Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Leu  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Asp Ser Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Phe  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Thr  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Ile Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Leu Ala Gln Asp Thr  Leu Asn Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Ser Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Glu Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Ser  Pro Arg Glu Leu Ser  Arg Val Ala 
    2915                 2920                 2925             


Ala Thr  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ala  Gln Gly Ala 
    2945                 2950                 2955             


Arg Ala  Ala Ile Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Ser  Arg Leu Asp 
    2975                 2980                 2985             


Leu Ser  Gly Trp Phe Thr Val  Gly Ala Gly Gly Gly  Gly Ile Tyr 
    2990                 2995                 3000             


His Ser  Val Ser His Ala Arg  Pro Arg Leu Leu Leu  Leu Cys Leu 
    3005                 3010                 3015             


Leu Leu  Leu Ser Val Gly Val  Gly Ile Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  121
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  121

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Arg Val Ile Asp Thr Ile Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Val Thr Val Pro Val Ser Ala Val 
            180                 185                 190         


Glu Val Arg Asn Ile Ser Ser Ser Tyr Tyr Ala Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Asn Ser Ile Thr Trp Gln Leu Thr Asp Ala Val Leu His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Asn Asp Asn Gly Thr Leu His Cys Trp Ile 
225                 230                 235                 240 


Gln Val Thr Pro Asn Val Ala Val Lys His Arg Gly Ala Leu Thr Arg 
                245                 250                 255     


Ser Leu Arg Thr His Val Asp Met Ile Val Met Ala Ala Thr Ala Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Val Cys Gly Ala Val Met Ile Leu Ser 
        275                 280                 285             


Gln Ala Phe Met Val Ser Pro Gln Arg His Asn Phe Thr Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Gln Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Leu Asn Trp Ser Pro Thr Leu Ala Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Ala Arg Val Pro Glu Met Val Leu Glu Ile Ile Phe Gly Gly His 
            340                 345                 350         


Trp Gly Val Val Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Ile Ala Ile Leu Leu Leu Val Ala Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr Tyr Ser Ser Gly Gln Glu Ala Gly Arg Thr Val Leu Gly Phe Thr 
385                 390                 395                 400 


Asn Leu Phe Thr Ser Gly Ala Lys Gln Asn Leu Tyr Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Met Ala Ser Leu Phe Tyr Thr His Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ser Ser Cys Arg Gly Leu Asp Asp 
    450                 455                 460                 


Phe Arg Ile Gly Trp Gly Thr Leu Glu Tyr Glu Thr His Val Thr Asn 
465                 470                 475                 480 


Asp Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys 
                485                 490                 495     


Gly Ile Val Pro Ala Arg Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Lys Gln Gly Val Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Arg Gly Ala Trp Phe Gly Cys Thr Trp Met Asn Gly Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Lys Asp 
                565                 570                 575     


Tyr Asn Ser Thr Ile Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Ala Thr Tyr Leu Lys Cys Gly Ala Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile Phe Lys Ala Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Phe Ser Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Arg Leu Glu Asp Arg Asp Arg Gly Gln Gln Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Val Leu Pro Cys Ser Phe Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Leu Thr Arg Tyr Ile Val Lys Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Ile Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Ile Ile Leu His Ser Ala Ser Ala Ala Ser Ala Asn Gly 
        755                 760                 765             


Pro Leu Trp Cys Phe Ile Phe Phe Thr Ala Ala Trp Tyr Leu Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Val Ala Thr Tyr Ser Val Leu Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Leu Leu Leu Val Leu Ala Leu Pro Gln Gln Ala Tyr Ala Leu Asp Ala 
                805                 810                 815     


Ala Glu Gln Gly Glu Leu Gly Leu Ala Ile Leu Val Ile Ile Ser Ile 
            820                 825                 830         


Phe Thr Leu Thr Pro Ala Tyr Lys Ile Leu Leu Ser Arg Ser Val Trp 
        835                 840                 845             


Trp Leu Ser Tyr Met Leu Val Leu Ala Glu Ala Gln Ile Gln Gln Arg 
    850                 855                 860                 


Val Pro Pro Leu Glu Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Val 
865                 870                 875                 880 


Ala Val Ile Leu His Pro Arg Leu Val Phe Glu Val Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Ile Leu Gly Pro Ala Tyr Leu Leu Lys Ala Ser Leu Leu Arg 
            900                 905                 910         


Ile Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Val Cys Thr Leu 
        915                 920                 925             


Val Lys His Leu Ala Gly Ala Arg Tyr Ile Gln Met Leu Leu Ile Thr 
    930                 935                 940                 


Ile Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Ser Pro Leu 
945                 950                 955                 960 


Ser Thr Trp Ala Ala Gln Gly Leu Arg Asp Leu Ala Ile Ala Val Glu 
                965                 970                 975     


Pro Val Val Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Val Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Lys Leu Leu  Ala Pro Ile Thr Ala  Tyr Thr Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Ala Ile Val Val Ser  Leu Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Asn Glu Gln Ala  Gly Gln Val Gln Val  Leu Ser Ser 
    1055                 1060                 1065             


Val Thr  Gln Thr Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Pro Lys 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Thr Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Asp  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Val Arg Arg Lys Asp  Asp Arg Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Ser Arg Gly His Ala  Val Gly Leu Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ala  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Ser Leu  Asp Val Ala Thr Arg  Thr Pro Ser Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Ser Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Ala Ala Tyr 
    1235                 1240                 1245             


Ala Ser  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Met Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Asp 
    1280                 1285                 1290             


Ser Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Ile Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Ala Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ser Val  Asp Ala Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Val Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Thr Val Thr  Thr Pro His Ser Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly His Glu Gly  Glu Ile Pro Phe Tyr  Gly Lys Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ala Phe Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Val Asn Ala Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Ser Gln Ile  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Val Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Ser Gly Glu  Arg Pro Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ala Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Gly Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Thr 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ala Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Ile Met  Thr Ser Ser Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Ile Ser  Ile Ile Gly Arg Leu  His Leu Asn Asp Arg  Val Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Ile Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Lys Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Met 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Thr Arg  Gln Ala Gln Asp Ile  Gln Pro Ala Ile Gln  Ser Ser Trp 
    1745                 1750                 1755             


Pro Lys  Leu Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Pro Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Met Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Ile Leu Val Asp Val  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Thr Val  Glu Asp Val Val Asn  Leu Leu Pro Ala Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Gln Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Val  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Val Leu Ser 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Ala Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Val Pro  Cys Ser Gly Ser Trp  Leu Gln Asp 
    1970                 1975                 1980             


Ile Trp  Asp Trp Val Cys Ser  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Ser  Ser Lys Leu Leu Pro  Lys Met Pro Gly Ile  Pro Phe Ile 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Val 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly His Val 
    2030                 2035                 2040             


Arg Met  Gly Thr Met Lys Ile  Thr Gly Pro Lys Thr  Cys Leu Asn 
    2045                 2050                 2055             


Leu Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Pro 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Pro Pro  Asn Tyr Lys Thr Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Val  Glu Val Thr Gln His  Gly Ser Phe 
    2090                 2095                 2100             


Ser Tyr  Val Thr Gly Leu Thr  Ser Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Val  Pro Ala Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Val  Pro Gly Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Thr  Phe Thr Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Glu Val Leu  Ala Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Ala Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Gln Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Lys Ala Thr Cys Thr  Thr His Lys 
    2210                 2215                 2220             


Thr Ala  Tyr Asp Cys Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Asp Ser Lys Val  Ile Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Ser Met Thr  Glu Val Val Asp Asp  Arg Glu Pro 
    2255                 2260                 2265             


Ser Val  Pro Ser Glu Tyr Leu  Ile Lys Arg Arg Lys  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Pro Trp Ala Arg  Pro Asp Tyr Asn Pro  Val Leu Ile 
    2285                 2290                 2295             


Glu Thr  Trp Lys Arg Pro Gly  Tyr Glu Pro Pro Thr  Val Leu Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Thr Pro  Gln Thr Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Ala Lys Val Leu  Thr Gln Asp Asn Val  Glu Gly Ile 
    2330                 2335                 2340             


Leu Arg  Glu Met Ala Asp Lys  Val Leu Ser Pro Leu  Gln Asp Asn 
    2345                 2350                 2355             


Asn Asp  Ser Gly His Ser Thr  Gly Ala Asp Thr Gly  Gly Asp Ile 
    2360                 2365                 2370             


Val Gln  Gln Pro Ser Asp Glu  Thr Ala Ala Ser Glu  Ala Gly Ser 
    2375                 2380                 2385             


Leu Ser  Ser Met Pro Pro Leu  Glu Gly Glu Pro Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Phe Glu Pro Val Gly  Ser Ala Pro Pro Ser  Glu Gly Glu 
    2405                 2410                 2415             


Cys Glu  Val Ile Asp Ser Asp  Ser Lys Ser Trp Ser  Thr Val Ser 
    2420                 2425                 2430             


Asp Gln  Glu Asp Ser Val Ile  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Gly Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Met Arg Phe  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Ser Thr Thr Ser Arg  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Val Gln  Val Leu Asp Ala His  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Gln Asp Val Lys Arg  Ala Ala Ser Lys Val  Ser Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Val Glu Glu Ala  Cys Ala Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Lys  Ser Arg Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Arg  Arg Ala Val Asn His  Ile Arg Ser Val Trp  Glu Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Gln His Thr Pro  Ile Asp Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Ile Asp  Pro Thr Lys Gly Gly  Lys Lys Pro 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Ala Gln Lys Leu Pro  Lys Ala Ile 
    2615                 2620                 2625             


Met Gly  Pro Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Glu Arg Val 
    2630                 2635                 2640             


Asp Phe  Leu Leu Lys Ala Trp  Gly Ser Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Gln Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Gln Glu  Ala Arg Thr Val Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Thr Asn  Ser Lys Gly Gln Ser  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Phe Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Met  Thr Cys Tyr Ile Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Val Asp Pro Val Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Asn Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Leu  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Asp Ser Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Phe  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Thr  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Ile Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Leu Ala Gln Asp Thr  Leu Asn Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Asn Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Glu Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Ser  Pro Arg Glu Leu Ser  Arg Val Ala 
    2915                 2920                 2925             


Ala Thr  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ala  Gln Gly Ala 
    2945                 2950                 2955             


Arg Ala  Ala Ile Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Ser  Arg Leu Asp 
    2975                 2980                 2985             


Leu Ser  Gly Trp Phe Thr Val  Gly Ala Gly Gly Gly  Gly Ile Tyr 
    2990                 2995                 3000             


His Ser  Val Ser His Ala Arg  Pro Arg Leu Leu Leu  Leu Cys Leu 
    3005                 3010                 3015             


Leu Leu  Leu Ser Val Gly Val  Gly Ile Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  122
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  122

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Arg Val Ile Asp Thr Ile Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Val Thr Val Pro Val Ser Ala Val 
            180                 185                 190         


Glu Val Arg Asn Ile Ser Ser Ser Tyr Tyr Ala Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Asn Ser Ile Thr Trp Gln Leu Thr Asp Ala Val Leu His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Asn Asp Asn Gly Thr Leu His Cys Trp Ile 
225                 230                 235                 240 


Gln Val Thr Pro Asn Val Ala Val Lys His Arg Gly Ala Leu Thr Arg 
                245                 250                 255     


Ser Leu Arg Thr His Val Asp Met Ile Val Met Ala Ala Thr Ala Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Val Cys Gly Ala Val Met Ile Leu Ser 
        275                 280                 285             


Gln Ala Phe Met Val Ser Pro Gln Arg His Asn Phe Thr Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Gln Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Leu Asn Trp Ser Pro Thr Leu Ala Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Ala Arg Val Pro Glu Met Val Leu Glu Ile Ile Phe Gly Gly His 
            340                 345                 350         


Trp Gly Val Val Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Ile Ala Ile Leu Leu Leu Val Ala Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr Tyr Ser Ser Gly Gln Glu Ala Gly Arg Thr Val Leu Gly Phe Thr 
385                 390                 395                 400 


Asn Leu Phe Thr Ser Gly Ala Lys Gln Asn Leu Tyr Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Met Ala Ser Leu Phe Tyr Thr His Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ser Ser Cys Arg Gly Leu Asp Asp 
    450                 455                 460                 


Phe Arg Ile Gly Trp Gly Thr Leu Glu Tyr Glu Thr His Val Thr Asn 
465                 470                 475                 480 


Asp Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys 
                485                 490                 495     


Gly Ile Val Pro Ala Arg Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Lys Gln Gly Val Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Arg Gly Ala Trp Phe Gly Cys Thr Trp Met Asn Gly Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Lys Asp 
                565                 570                 575     


Tyr Asn Ser Thr Ile Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Ala Thr Tyr Leu Lys Cys Gly Ala Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile Phe Lys Ala Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Phe Ser Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Arg Leu Glu Asp Arg Asp Arg Gly Gln Gln Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Val Leu Pro Cys Ser Phe Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Leu Thr Arg Tyr Ile Val Lys Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Ile Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Ile Ile Leu His Ser Ala Ser Ala Ala Ser Ala Asn Gly 
        755                 760                 765             


Pro Leu Trp Cys Phe Ile Phe Phe Thr Ala Ala Trp Tyr Leu Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Val Ala Thr Tyr Ser Val Leu Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Leu Leu Leu Val Leu Ala Leu Pro Gln Gln Ala Tyr Ala Leu Asp Ala 
                805                 810                 815     


Ala Glu Gln Gly Glu Leu Gly Leu Ala Ile Leu Val Ile Ile Ser Ile 
            820                 825                 830         


Phe Thr Leu Thr Pro Ala Tyr Lys Ile Leu Leu Ser Arg Ser Val Trp 
        835                 840                 845             


Trp Leu Ser Tyr Met Leu Val Leu Ala Glu Ala Gln Ile Gln Gln Arg 
    850                 855                 860                 


Val Pro Pro Leu Glu Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Val 
865                 870                 875                 880 


Ala Val Ile Leu His Pro Arg Leu Val Phe Glu Val Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Ile Leu Gly Pro Ala Tyr Leu Leu Lys Ala Ser Leu Leu Arg 
            900                 905                 910         


Ile Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Val Cys Thr Leu 
        915                 920                 925             


Val Lys His Leu Ala Gly Ala Arg Tyr Ile Gln Met Leu Leu Ile Thr 
    930                 935                 940                 


Ile Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Ser Pro Leu 
945                 950                 955                 960 


Ser Thr Trp Ala Ala Gln Gly Leu Arg Asp Leu Ala Ile Ala Val Glu 
                965                 970                 975     


Pro Val Val Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Val Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Lys Leu Leu  Ala Pro Ile Thr Ala  Tyr Thr Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Ala Ile Val Val Ser  Leu Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Asn Glu Gln Ala  Gly Gln Val Gln Val  Leu Ser Ser 
    1055                 1060                 1065             


Val Thr  Gln Thr Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Pro Lys 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Thr Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Asp  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Val Arg Arg Lys Asp  Asp Arg Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Ser Arg Gly His Ala  Val Gly Leu Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ala  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Ser Leu  Asp Val Thr Thr Arg  Thr Pro Ser Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Ser Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Ala Ala Tyr 
    1235                 1240                 1245             


Ala Ser  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Met Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Asp 
    1280                 1285                 1290             


Ser Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Ile Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Ala Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ser Val  Asp Ala Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Val Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Thr Val Thr  Thr Pro His Ser Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly His Glu Gly  Glu Ile Pro Phe Tyr  Gly Lys Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ala Phe Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Val Asn Ala Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Ser Gln Ile  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Val Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Ser Gly Glu  Arg Pro Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ala Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Gly Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Thr 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ala Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Ile Met  Thr Ser Ser Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Ile Ser  Ile Ile Gly Arg Leu  His Leu Asn Asp Arg  Val Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Ile Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Lys Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Met 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Thr Arg  Gln Ala Gln Asp Ile  Gln Pro Ala Ile Gln  Ser Ser Trp 
    1745                 1750                 1755             


Pro Lys  Leu Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Pro Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Met Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Ile Leu Val Asp Val  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Thr Val  Glu Asp Val Val Asn  Leu Leu Pro Ala Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Gln Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Val  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Val Leu Ser 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Ala Trp Val 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Val Pro  Cys Ser Gly Ser Trp  Leu Gln Asp 
    1970                 1975                 1980             


Ile Trp  Asp Trp Val Cys Ser  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Ser  Ser Lys Leu Leu Pro  Lys Met Pro Gly Ile  Pro Phe Ile 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Val 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly His Val 
    2030                 2035                 2040             


Arg Met  Gly Thr Met Lys Ile  Thr Gly Pro Lys Thr  Cys Leu Asn 
    2045                 2050                 2055             


Leu Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Pro 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Pro Pro  Asn Tyr Lys Thr Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Val  Glu Val Thr Gln His  Gly Ser Phe 
    2090                 2095                 2100             


Ser Tyr  Val Thr Gly Leu Thr  Ser Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Val  Pro Ala Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Val  Pro Gly Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Thr  Phe Thr Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Glu Val Leu  Ala Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Ala Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Gln Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Lys Ala Thr Cys Thr  Thr His Lys 
    2210                 2215                 2220             


Thr Ala  Tyr Asp Cys Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Asp Ser Lys Val  Ile Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Ser Met Thr  Glu Val Val Asp Asp  Arg Glu Pro 
    2255                 2260                 2265             


Ser Val  Pro Ser Glu Tyr Leu  Ile Lys Arg Arg Lys  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Pro Trp Ala Arg  Pro Asp Tyr Asn Pro  Val Leu Ile 
    2285                 2290                 2295             


Glu Thr  Trp Lys Arg Pro Gly  Tyr Glu Pro Pro Thr  Val Leu Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Thr Pro  Gln Thr Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Ala Lys Val Leu  Thr Gln Asp Asn Val  Glu Gly Ile 
    2330                 2335                 2340             


Leu Arg  Glu Met Ala Asp Lys  Val Leu Ser Pro Leu  Gln Asp Asn 
    2345                 2350                 2355             


Asn Asp  Ser Gly His Ser Thr  Gly Ala Asp Thr Gly  Gly Asp Ile 
    2360                 2365                 2370             


Val Gln  Gln Pro Ser Asp Glu  Thr Ala Ala Ser Glu  Ala Gly Ser 
    2375                 2380                 2385             


Leu Ser  Ser Met Pro Pro Leu  Glu Gly Glu Pro Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Phe Glu Pro Val Gly  Ser Ala Pro Pro Ser  Glu Gly Glu 
    2405                 2410                 2415             


Cys Glu  Val Ile Asp Ser Asp  Ser Lys Ser Trp Ser  Thr Val Ser 
    2420                 2425                 2430             


Asp Gln  Glu Asp Ser Val Ile  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Gly Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Met Arg Phe  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Ser Thr Thr Ser Arg  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Val Gln  Val Leu Asp Ala His  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Gln Asp Val Lys Arg  Ala Ala Ser Lys Val  Ser Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Val Glu Glu Ala  Cys Ala Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Lys  Ser Arg Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Arg  Arg Ala Val Asn His  Ile Arg Ser Val Trp  Glu Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Gln His Thr Pro  Ile Asp Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Ile Asp  Pro Thr Lys Gly Gly  Lys Lys Pro 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Ala Gln Lys Leu Pro  Lys Ala Ile 
    2615                 2620                 2625             


Met Gly  Pro Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Glu Arg Val 
    2630                 2635                 2640             


Asp Phe  Leu Leu Lys Ala Trp  Gly Ser Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Gln Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Gln Glu  Ala Arg Thr Val Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Thr Asn  Ser Lys Gly Gln Ser  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Phe Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Met  Thr Cys Tyr Ile Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Val Asp Pro Val Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Asn Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Leu  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Asp Ser Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Phe  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Thr  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Ile Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Leu Ala Gln Asp Thr  Leu Asn Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Asn Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Glu Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Ser  Pro Arg Glu Leu Ser  Arg Val Ala 
    2915                 2920                 2925             


Ala Thr  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ala  Gln Gly Ala 
    2945                 2950                 2955             


Arg Ala  Ala Ile Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Ser  Arg Leu Asp 
    2975                 2980                 2985             


Leu Ser  Gly Trp Phe Thr Val  Gly Ala Gly Gly Gly  Gly Ile Tyr 
    2990                 2995                 3000             


His Ser  Val Ser His Ala Arg  Pro Arg Leu Leu Leu  Leu Cys Leu 
    3005                 3010                 3015             


Leu Leu  Leu Ser Val Gly Val  Gly Ile Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  123
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  123

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Arg Val Ile Asp Thr Ile Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Val Thr Val Pro Val Ser Ala Val 
            180                 185                 190         


Glu Val Arg Asn Ile Ser Ser Ser Tyr Tyr Ala Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Asn Ser Ile Thr Trp Gln Leu Thr Asp Ala Val Leu His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Asn Asp Asn Gly Thr Leu His Cys Trp Ile 
225                 230                 235                 240 


Gln Val Thr Pro Asn Val Ala Val Lys His Arg Gly Ala Leu Thr Arg 
                245                 250                 255     


Ser Leu Arg Thr His Val Asp Met Ile Val Met Ala Ala Thr Ala Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Val Cys Gly Ala Val Met Ile Leu Ser 
        275                 280                 285             


Gln Ala Phe Met Val Ser Pro Gln Arg His Asn Phe Thr Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Gln Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Leu Asn Trp Ser Pro Thr Leu Ala Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Ala Arg Val Pro Glu Met Val Leu Glu Ile Ile Phe Gly Gly His 
            340                 345                 350         


Trp Gly Val Val Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Ile Ala Ile Leu Leu Leu Val Ala Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr Tyr Ser Ser Gly Gln Glu Ala Gly Arg Thr Val Leu Gly Phe Thr 
385                 390                 395                 400 


Asn Leu Phe Thr Ser Gly Ala Lys Gln Asn Leu Tyr Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Met Ala Ser Leu Phe Tyr Thr His Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ser Ser Cys Arg Gly Leu Asp Asp 
    450                 455                 460                 


Phe Arg Ile Gly Trp Gly Thr Leu Glu Tyr Glu Thr His Val Thr Asn 
465                 470                 475                 480 


Asp Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys 
                485                 490                 495     


Gly Ile Val Pro Ala Arg Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Lys Gln Gly Val Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Arg Gly Ala Trp Phe Gly Cys Thr Trp Met Asn Gly Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Lys Asp 
                565                 570                 575     


Tyr Asn Ser Thr Ile Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Ala Thr Tyr Leu Lys Cys Gly Ala Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile Phe Lys Ala Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Phe Ser Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Arg Leu Glu Asp Arg Asp Arg Gly Gln Gln Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Val Leu Pro Cys Ser Phe Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Leu Thr Arg Tyr Ile Val Lys Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Ile Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Ile Ile Leu His Ser Ala Ser Ala Ala Ser Ala Asn Gly 
        755                 760                 765             


Pro Leu Trp Cys Phe Ile Phe Phe Thr Ala Ala Trp Tyr Leu Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Val Ala Thr Tyr Ser Val Leu Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Leu Leu Leu Val Leu Ala Leu Pro Gln Gln Ala Tyr Ala Leu Asp Ala 
                805                 810                 815     


Ala Glu Gln Gly Glu Leu Gly Leu Ala Ile Leu Val Ile Ile Ser Ile 
            820                 825                 830         


Phe Thr Leu Thr Pro Ala Tyr Lys Ile Leu Leu Ser Arg Ser Val Trp 
        835                 840                 845             


Trp Leu Ser Tyr Met Leu Val Leu Ala Glu Ala Gln Ile Gln Gln Trp 
    850                 855                 860                 


Val Pro Pro Leu Glu Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Val 
865                 870                 875                 880 


Ala Val Ile Leu His Pro Arg Leu Val Phe Glu Val Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Ile Leu Gly Pro Ala Tyr Leu Leu Lys Ala Ser Leu Leu Arg 
            900                 905                 910         


Ile Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Val Cys Thr Leu 
        915                 920                 925             


Val Lys His Leu Ala Gly Ala Arg Tyr Ile Gln Met Leu Leu Ile Thr 
    930                 935                 940                 


Ile Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Ser Pro Leu 
945                 950                 955                 960 


Ser Thr Trp Ala Ala Gln Gly Leu Arg Asp Leu Ala Ile Ala Val Glu 
                965                 970                 975     


Pro Val Val Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Val Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Lys Leu Leu  Ala Pro Ile Thr Ala  Tyr Thr Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Ala Ile Val Val Ser  Leu Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Asn Glu Gln Ala  Gly Gln Val Gln Val  Leu Ser Ser 
    1055                 1060                 1065             


Val Thr  Gln Thr Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Pro Lys 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Thr Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Asp  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Val Arg Arg Lys Asp  Asp Arg Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Ser Arg Gly His Ala  Val Gly Leu Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ala  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Ser Leu  Asp Val Ala Thr Arg  Thr Pro Ser Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Ser Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Ala Ala Tyr 
    1235                 1240                 1245             


Ala Ser  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Met Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Asp 
    1280                 1285                 1290             


Ser Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Ile Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Ala Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ser Val  Asp Ala Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Val Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Thr Val Thr  Thr Pro His Ser Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly His Glu Gly  Glu Ile Pro Phe Tyr  Gly Lys Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ala Phe Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Val Asn Ala Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Ser Gln Ile  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Val Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Ser Gly Glu  Arg Pro Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ala Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Gly Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Thr 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ala Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Ile Met  Thr Ser Ser Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Ile Ser  Ile Ile Gly Arg Leu  His Leu Asn Asp Arg  Val Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Ile Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Lys Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Met 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Thr Arg  Gln Ala Gln Asp Ile  Gln Pro Ala Ile Gln  Ser Ser Trp 
    1745                 1750                 1755             


Pro Lys  Leu Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Pro Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Met Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Ile Leu Val Asp Val  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Thr Val  Glu Asp Val Val Asn  Leu Leu Pro Ala Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Gln Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Val  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Val Leu Ser 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Ala Trp Ile 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Val Pro  Cys Ser Gly Ser Trp  Leu Gln Asp 
    1970                 1975                 1980             


Ile Trp  Asp Trp Val Cys Ser  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Ser  Ser Lys Leu Leu Pro  Lys Met Pro Gly Ile  Pro Phe Ile 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Val 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly His Val 
    2030                 2035                 2040             


Arg Met  Gly Thr Met Lys Ile  Thr Gly Pro Lys Thr  Cys Leu Asn 
    2045                 2050                 2055             


Leu Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Pro 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Pro Pro  Asn Tyr Lys Thr Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Val  Glu Val Thr Gln His  Gly Ser Phe 
    2090                 2095                 2100             


Ser Tyr  Val Thr Gly Leu Thr  Ser Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Val  Pro Ala Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Val  Pro Gly Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Thr  Phe Thr Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Glu Val Leu  Ala Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Ala Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Gln Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Lys Ala Thr Cys Thr  Thr His Lys 
    2210                 2215                 2220             


Thr Ala  Tyr Asp Cys Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Asp Ser Lys Val  Ile Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Ser Met Thr  Glu Val Val Asp Asp  Arg Glu Pro 
    2255                 2260                 2265             


Ser Val  Pro Ser Glu Tyr Leu  Ile Lys Arg Arg Lys  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Pro Trp Ala Arg  Pro Asp Tyr Asn Pro  Val Leu Ile 
    2285                 2290                 2295             


Glu Thr  Trp Lys Arg Pro Gly  Tyr Glu Pro Pro Thr  Val Leu Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Thr Pro  Gln Thr Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Ala Lys Val Leu  Thr Gln Asp Asn Val  Glu Gly Ile 
    2330                 2335                 2340             


Leu Arg  Glu Met Ala Asp Lys  Val Leu Ser Pro Leu  Gln Asp Asn 
    2345                 2350                 2355             


Asn Asp  Ser Gly His Ser Thr  Gly Ala Asp Thr Gly  Gly Asp Ile 
    2360                 2365                 2370             


Val Gln  Gln Pro Ser Asp Glu  Thr Ala Ala Ser Glu  Ala Gly Ser 
    2375                 2380                 2385             


Leu Ser  Ser Met Pro Pro Leu  Glu Gly Glu Pro Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Phe Glu Pro Val Gly  Ser Ala Pro Pro Ser  Glu Gly Glu 
    2405                 2410                 2415             


Cys Glu  Val Ile Asp Ser Asp  Ser Lys Ser Trp Ser  Thr Val Ser 
    2420                 2425                 2430             


Asp Gln  Glu Asp Ser Val Ile  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Gly Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Met Arg Phe  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Ser Thr Thr Ser Arg  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Val Gln  Val Leu Asp Ala His  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Gln Asp Val Lys Arg  Ala Ala Ser Lys Val  Ser Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Val Glu Glu Ala  Cys Ala Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Lys  Ser Arg Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Arg  Arg Ala Val Asn His  Ile Arg Ser Val Trp  Glu Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Gln His Thr Pro  Ile Asp Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Ile Asp  Pro Thr Lys Gly Gly  Lys Lys Pro 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Ala Gln Lys Leu Pro  Lys Ala Ile 
    2615                 2620                 2625             


Met Gly  Pro Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Glu Arg Val 
    2630                 2635                 2640             


Asp Phe  Leu Leu Lys Ala Trp  Gly Ser Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Gln Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Gln Glu  Ala Arg Thr Val Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Thr Asn  Ser Lys Gly Gln Ser  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Phe Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Met  Thr Cys Tyr Ile Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Val Asp Pro Val Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Asn Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Leu  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Asp Ser Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Phe  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Thr  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Ile Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Leu Ala Gln Asp Thr  Leu Asn Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Asn Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Glu Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Ser  Pro Arg Glu Leu Ser  Arg Val Ala 
    2915                 2920                 2925             


Ala Thr  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ala  Gln Gly Ala 
    2945                 2950                 2955             


Arg Ala  Ala Ile Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Ser  Arg Leu Asp 
    2975                 2980                 2985             


Leu Ser  Gly Trp Phe Thr Val  Gly Ala Gly Gly Gly  Gly Ile Tyr 
    2990                 2995                 3000             


His Ser  Val Ser His Ala Arg  Pro Arg Leu Leu Leu  Leu Cys Leu 
    3005                 3010                 3015             


Leu Leu  Leu Ser Val Gly Val  Gly Ile Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  124
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  124

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Arg Val Ile Asp Thr Ile Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Val Thr Val Pro Val Ser Ala Val 
            180                 185                 190         


Glu Val Arg Asn Ile Ser Ser Ser Tyr Tyr Ala Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Asn Ser Ile Thr Trp Gln Leu Thr Asp Ala Val Leu His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Asn Asp Asn Gly Thr Leu His Cys Trp Ile 
225                 230                 235                 240 


Gln Val Thr Pro Asn Val Ala Val Lys His Arg Gly Ala Leu Thr Arg 
                245                 250                 255     


Ser Leu Arg Thr His Val Asp Met Ile Val Met Ala Ala Thr Ala Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Val Cys Gly Ala Val Met Ile Leu Ser 
        275                 280                 285             


Gln Ala Phe Met Val Ser Pro Gln Arg His Asn Phe Thr Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Gln Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Leu Asn Trp Ser Pro Thr Leu Ala Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Ala Arg Val Pro Glu Met Val Leu Glu Ile Ile Phe Gly Gly His 
            340                 345                 350         


Trp Gly Val Val Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Ile Ala Ile Leu Leu Leu Val Ala Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr Tyr Ser Ser Gly Gln Glu Ala Gly Arg Thr Val Leu Gly Phe Thr 
385                 390                 395                 400 


Asn Leu Phe Thr Ser Gly Ala Lys Gln Asn Leu Tyr Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Met Ala Ser Leu Phe Tyr Thr His Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ser Ser Cys Arg Gly Leu Asp Asp 
    450                 455                 460                 


Phe Arg Ile Gly Trp Gly Thr Leu Glu Tyr Glu Thr His Val Thr Asn 
465                 470                 475                 480 


Asp Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys 
                485                 490                 495     


Gly Ile Val Pro Ala Arg Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Lys Gln Gly Val Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Arg Gly Ala Trp Phe Gly Cys Thr Trp Met Asn Gly Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Lys Asp 
                565                 570                 575     


Tyr Asn Ser Thr Ile Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Ala Thr Tyr Leu Lys Cys Gly Ala Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile Phe Lys Ala Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Phe Ser Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Arg Leu Glu Asp Arg Asp Arg Gly Gln Gln Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Val Leu Pro Cys Ser Phe Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Leu Thr Arg Tyr Ile Val Lys Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Ile Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Ile Ile Leu His Ser Ala Ser Ala Ala Ser Ala Asn Gly 
        755                 760                 765             


Pro Leu Trp Cys Phe Ile Phe Phe Thr Ala Ala Trp Tyr Leu Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Val Ala Thr Tyr Ser Val Leu Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Leu Leu Leu Val Leu Ala Leu Pro Gln Gln Ala Tyr Ala Leu Asp Ala 
                805                 810                 815     


Ala Glu Gln Gly Glu Leu Gly Leu Ala Ile Leu Val Ile Ile Ser Ile 
            820                 825                 830         


Phe Thr Leu Thr Pro Ala Tyr Lys Ile Leu Leu Ser Arg Ser Val Trp 
        835                 840                 845             


Trp Leu Ser Tyr Met Leu Val Leu Ala Glu Ala Gln Ile Gln Gln Trp 
    850                 855                 860                 


Val Pro Pro Leu Glu Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Val 
865                 870                 875                 880 


Ala Val Ile Leu His Pro Arg Leu Val Phe Glu Val Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Ile Leu Gly Pro Ala Tyr Leu Leu Lys Ala Ser Leu Leu Arg 
            900                 905                 910         


Ile Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Val Cys Thr Leu 
        915                 920                 925             


Val Lys His Leu Ala Gly Ala Arg Tyr Ile Gln Met Leu Leu Ile Thr 
    930                 935                 940                 


Ile Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Ser Pro Leu 
945                 950                 955                 960 


Ser Thr Trp Ala Ala Gln Gly Leu Arg Asp Leu Ala Ile Ala Val Glu 
                965                 970                 975     


Pro Val Val Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Val Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Lys Leu Leu  Ala Pro Ile Thr Ala  Tyr Thr Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Ala Ile Val Val Ser  Leu Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Asn Glu Gln Ala  Gly Gln Val Gln Val  Leu Ser Ser 
    1055                 1060                 1065             


Val Thr  Gln Thr Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Pro Lys 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Thr Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Asp  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Val Arg Arg Lys Asp  Asp Arg Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Ser Arg Gly His Ala  Val Gly Leu Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ala  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Ser Leu  Asp Val Ala Thr Arg  Thr Pro Ser Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Ser Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Ala Ala Tyr 
    1235                 1240                 1245             


Ala Ser  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Met Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Asp 
    1280                 1285                 1290             


Ser Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Ile Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Ala Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ser Val  Asp Ala Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Val Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Thr Val Thr  Thr Pro His Ser Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly His Glu Gly  Glu Ile Pro Phe Tyr  Gly Lys Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ala Phe Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Val Asn Ala Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Ser Gln Ile  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Val Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Ser Gly Glu  Arg Pro Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ala Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Gly Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Thr 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ala Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Ile Met  Thr Ser Ser Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Ile Ser  Ile Ile Gly Arg Leu  His Leu Asn Asp Arg  Val Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Ile Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Lys Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Met 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Thr Arg  Gln Ala Gln Asp Ile  Gln Pro Ala Ile Gln  Ser Ser Trp 
    1745                 1750                 1755             


Pro Lys  Leu Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Pro Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Met Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Ile Leu Val Asp Val  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Thr Val  Glu Asp Val Val Asn  Leu Leu Pro Ala Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Gln Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Val  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Val Leu Ser 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Ala Trp Val 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Val Pro  Cys Ser Gly Ser Trp  Leu Gln Asp 
    1970                 1975                 1980             


Ile Trp  Asp Trp Val Cys Ser  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Ser  Ser Lys Leu Leu Pro  Lys Met Pro Gly Ile  Pro Phe Ile 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Val 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly His Val 
    2030                 2035                 2040             


Arg Met  Gly Thr Met Lys Ile  Thr Gly Pro Lys Thr  Cys Leu Asn 
    2045                 2050                 2055             


Leu Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Pro 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Pro Pro  Asn Tyr Lys Thr Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Val  Glu Val Thr Gln His  Gly Ser Phe 
    2090                 2095                 2100             


Ser Tyr  Val Thr Gly Leu Thr  Ser Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Val  Pro Ala Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Val  Pro Gly Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Thr  Phe Thr Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Glu Val Leu  Ala Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Ala Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Gln Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Lys Ala Thr Cys Thr  Thr His Lys 
    2210                 2215                 2220             


Thr Ala  Tyr Asp Cys Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Asp Ser Lys Val  Ile Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Ser Met Thr  Glu Val Val Asp Asp  Arg Glu Pro 
    2255                 2260                 2265             


Ser Val  Pro Ser Glu Tyr Leu  Ile Lys Arg Arg Lys  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Pro Trp Ala Arg  Pro Asp Tyr Asn Pro  Val Leu Ile 
    2285                 2290                 2295             


Glu Thr  Trp Lys Arg Pro Gly  Tyr Glu Pro Pro Thr  Val Leu Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Thr Pro  Gln Thr Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Ala Lys Val Leu  Thr Gln Asp Asn Val  Glu Gly Ile 
    2330                 2335                 2340             


Leu Arg  Glu Met Ala Asp Lys  Val Leu Ser Pro Leu  Gln Asp Asn 
    2345                 2350                 2355             


Asn Asp  Ser Gly His Ser Thr  Gly Ala Asp Thr Gly  Gly Asp Ile 
    2360                 2365                 2370             


Val Gln  Gln Pro Ser Asp Glu  Thr Ala Ala Ser Glu  Ala Gly Ser 
    2375                 2380                 2385             


Leu Ser  Ser Met Pro Pro Leu  Glu Gly Glu Pro Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Phe Glu Pro Val Gly  Ser Ala Pro Pro Ser  Glu Gly Glu 
    2405                 2410                 2415             


Cys Glu  Val Ile Asp Ser Asp  Ser Lys Ser Trp Ser  Thr Val Ser 
    2420                 2425                 2430             


Asp Gln  Glu Asp Ser Val Ile  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Gly Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Met Arg Phe  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Ser Thr Thr Ser Arg  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Val Gln  Val Leu Asp Ala His  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Gln Asp Val Lys Arg  Ala Ala Ser Lys Val  Ser Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Val Glu Glu Ala  Cys Ala Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Lys  Ser Arg Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Arg  Arg Ala Val Asn His  Ile Arg Ser Val Trp  Glu Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Gln His Thr Pro  Ile Asp Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Ile Asp  Pro Thr Lys Gly Gly  Lys Lys Pro 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Ala Gln Lys Leu Pro  Lys Ala Ile 
    2615                 2620                 2625             


Met Gly  Pro Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Glu Arg Val 
    2630                 2635                 2640             


Asp Phe  Leu Leu Lys Ala Trp  Gly Ser Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Gln Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Gln Glu  Ala Arg Thr Val Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Thr Asn  Ser Lys Gly Gln Ser  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Phe Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Met  Thr Cys Tyr Ile Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Val Asp Pro Val Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Asn Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Leu  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Asp Ser Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Phe  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Thr  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Ile Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Leu Ala Gln Asp Thr  Leu Asn Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Asn Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Glu Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Ser  Pro Arg Glu Leu Ser  Arg Val Ala 
    2915                 2920                 2925             


Ala Thr  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ala  Gln Gly Ala 
    2945                 2950                 2955             


Arg Ala  Ala Ile Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Ser  Arg Leu Asp 
    2975                 2980                 2985             


Leu Ser  Gly Trp Phe Thr Val  Gly Ala Gly Gly Gly  Gly Ile Tyr 
    2990                 2995                 3000             


His Ser  Val Ser His Ala Arg  Pro Arg Leu Leu Leu  Leu Cys Leu 
    3005                 3010                 3015             


Leu Leu  Leu Ser Val Gly Val  Gly Ile Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  125
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  125

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Arg Val Ile Asp Thr Ile Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Val Thr Val Pro Val Ser Ala Val 
            180                 185                 190         


Glu Val Arg Asn Ile Ser Ser Ser Tyr Tyr Ala Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Asn Ser Ile Thr Trp Gln Leu Thr Asp Ala Val Leu His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Asn Asp Asn Gly Thr Leu His Cys Trp Ile 
225                 230                 235                 240 


Gln Val Thr Pro Asn Val Ala Val Lys His Arg Gly Ala Leu Thr Arg 
                245                 250                 255     


Ser Leu Arg Thr His Val Asp Met Ile Val Met Ala Ala Thr Ala Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Val Cys Gly Ala Val Met Ile Leu Ser 
        275                 280                 285             


Gln Ala Phe Met Val Ser Pro Gln Arg His Asn Phe Thr Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Gln Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Leu Asn Trp Ser Pro Thr Leu Ala Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Ala Arg Val Pro Glu Met Val Leu Glu Ile Ile Phe Gly Gly His 
            340                 345                 350         


Trp Gly Val Val Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Ile Ala Ile Leu Leu Leu Val Ala Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr Tyr Ser Ser Gly Gln Glu Ala Gly Arg Thr Val Leu Gly Phe Thr 
385                 390                 395                 400 


Asn Leu Phe Thr Ser Gly Ala Lys Gln Asn Leu Tyr Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Met Ala Ser Leu Phe Tyr Thr His Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ser Ser Cys Arg Gly Leu Asp Asp 
    450                 455                 460                 


Phe Arg Ile Gly Trp Gly Thr Leu Glu Tyr Glu Thr His Val Thr Asn 
465                 470                 475                 480 


Asp Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys 
                485                 490                 495     


Gly Ile Val Pro Ala Arg Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Lys Gln Gly Val Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Arg Gly Ala Trp Phe Gly Cys Thr Trp Met Asn Gly Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Lys Asp 
                565                 570                 575     


Tyr Asn Ser Thr Ile Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Ala Thr Tyr Leu Lys Cys Gly Ala Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile Phe Lys Ala Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Phe Ser Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Arg Leu Glu Asp Arg Asp Arg Gly Gln Gln Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Val Leu Pro Cys Ser Phe Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Leu Thr Arg Tyr Ile Val Lys Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Ile Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Ile Ile Leu His Ser Ala Ser Ala Ala Ser Ala Asn Gly 
        755                 760                 765             


Pro Leu Trp Phe Phe Ile Phe Phe Thr Ala Ala Trp Tyr Leu Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Val Ala Thr Tyr Ser Val Leu Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Leu Leu Leu Val Leu Ala Leu Pro Gln Gln Ala Tyr Ala Leu Asp Ala 
                805                 810                 815     


Ala Glu Gln Gly Glu Leu Gly Leu Ala Ile Leu Val Ile Ile Ser Ile 
            820                 825                 830         


Phe Thr Leu Thr Pro Ala Tyr Lys Ile Leu Leu Ser Arg Ser Val Trp 
        835                 840                 845             


Trp Leu Ser Tyr Met Leu Val Leu Ala Glu Ala Gln Ile Gln Gln Trp 
    850                 855                 860                 


Val Pro Pro Leu Glu Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Val 
865                 870                 875                 880 


Ala Val Ile Leu His Pro Arg Leu Val Phe Glu Val Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Ile Leu Gly Pro Ala Tyr Leu Leu Lys Ala Ser Leu Leu Arg 
            900                 905                 910         


Ile Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Val Cys Thr Leu 
        915                 920                 925             


Val Lys His Leu Ala Gly Ala Arg Tyr Ile Gln Met Leu Leu Ile Thr 
    930                 935                 940                 


Ile Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Ser Pro Leu 
945                 950                 955                 960 


Ser Thr Trp Ala Ala Gln Gly Leu Arg Asp Leu Ala Ile Ala Val Glu 
                965                 970                 975     


Pro Val Val Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Val Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Lys Leu Leu  Ala Pro Ile Thr Ala  Tyr Thr Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Ala Ile Val Val Ser  Leu Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Asn Glu Gln Ala  Gly Gln Val Gln Val  Leu Ser Ser 
    1055                 1060                 1065             


Val Thr  Gln Thr Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Pro Lys 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Thr Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Asp  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Val Arg Arg Lys Asp  Asp Arg Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Ser Arg Gly His Ala  Val Gly Leu Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ala  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Ser Leu  Asp Val Ala Thr Arg  Thr Pro Ser Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Ser Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Ala Ala Tyr 
    1235                 1240                 1245             


Ala Ser  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Met Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Asp 
    1280                 1285                 1290             


Ser Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Ile Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Ala Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ser Val  Asp Ala Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Val Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Thr Val Thr  Thr Pro His Ser Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly His Glu Gly  Glu Ile Pro Phe Tyr  Gly Lys Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ala Phe Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Val Asn Ala Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Ser Gln Ile  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Val Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Ser Gly Glu  Arg Pro Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ala Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Gly Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Thr 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ala Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Ile Met  Thr Ser Ser Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Ile Ser  Ile Ile Gly Arg Leu  His Leu Asn Asp Arg  Val Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Ile Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Lys Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Met 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Thr Arg  Gln Ala Gln Asp Ile  Gln Pro Ala Ile Gln  Ser Ser Trp 
    1745                 1750                 1755             


Pro Lys  Leu Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Pro Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Met Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Ile Leu Val Asp Val  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Thr Val  Glu Asp Val Val Asn  Leu Leu Pro Ala Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Gln Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Val  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Val Leu Ser 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Ala Trp Val 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Val Pro  Cys Ser Gly Ser Trp  Leu Gln Asp 
    1970                 1975                 1980             


Ile Trp  Asp Trp Val Cys Ser  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Ser  Ser Lys Leu Leu Pro  Lys Met Pro Gly Ile  Pro Phe Ile 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Val 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly His Val 
    2030                 2035                 2040             


Arg Met  Gly Thr Met Lys Ile  Thr Gly Pro Lys Thr  Cys Leu Asn 
    2045                 2050                 2055             


Leu Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Pro 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Pro Pro  Asn Tyr Lys Thr Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Val  Glu Val Thr Gln His  Gly Ser Phe 
    2090                 2095                 2100             


Ser Tyr  Val Thr Gly Leu Thr  Ser Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Val  Pro Ala Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Val  Pro Gly Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Thr  Phe Thr Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Glu Val Leu  Ala Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Ala Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Gln Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Lys Ala Thr Cys Thr  Thr His Lys 
    2210                 2215                 2220             


Thr Ala  Tyr Asp Cys Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Asp Ser Lys Val  Ile Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Ser Met Thr  Glu Val Val Asp Asp  Arg Glu Pro 
    2255                 2260                 2265             


Ser Val  Pro Ser Glu Tyr Leu  Ile Lys Arg Arg Lys  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Pro Trp Ala Arg  Pro Asp Tyr Asn Pro  Val Leu Ile 
    2285                 2290                 2295             


Glu Thr  Trp Lys Arg Pro Gly  Tyr Glu Pro Pro Thr  Val Leu Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Thr Pro  Gln Thr Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Ala Lys Val Leu  Thr Gln Asp Asn Val  Glu Gly Ile 
    2330                 2335                 2340             


Leu Arg  Glu Met Ala Asp Lys  Val Leu Ser Pro Leu  Gln Asp Asn 
    2345                 2350                 2355             


Asn Asp  Ser Gly His Ser Thr  Gly Ala Asp Thr Gly  Gly Asp Ile 
    2360                 2365                 2370             


Val Gln  Gln Pro Ser Asp Glu  Thr Ala Ala Ser Glu  Ala Gly Ser 
    2375                 2380                 2385             


Leu Ser  Ser Met Pro Pro Leu  Glu Gly Glu Pro Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Phe Glu Pro Val Gly  Ser Ala Pro Pro Ser  Glu Gly Glu 
    2405                 2410                 2415             


Cys Glu  Val Ile Asp Ser Asp  Ser Lys Ser Trp Ser  Thr Val Ser 
    2420                 2425                 2430             


Asp Gln  Glu Asp Ser Val Ile  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Gly Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Met Arg Phe  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Ser Thr Thr Ser Arg  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Val Gln  Val Leu Asp Ala His  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Gln Asp Val Lys Arg  Ala Ala Ser Lys Val  Ser Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Val Glu Glu Ala  Cys Ala Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Lys  Ser Arg Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Arg  Arg Ala Val Asn His  Ile Arg Ser Val Trp  Glu Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Gln His Thr Pro  Ile Asp Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Ile Asp  Pro Thr Lys Gly Gly  Lys Lys Pro 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Ala Gln Lys Leu Pro  Lys Ala Ile 
    2615                 2620                 2625             


Met Gly  Pro Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Glu Arg Val 
    2630                 2635                 2640             


Asp Phe  Leu Leu Lys Ala Trp  Gly Ser Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Gln Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Gln Glu  Ala Arg Thr Val Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Thr Asn  Ser Lys Gly Gln Ser  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Phe Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Met  Thr Cys Tyr Ile Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Val Asp Pro Val Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Asn Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Leu  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Asp Ser Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Phe  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Thr  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Ile Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Leu Ala Gln Asp Thr  Leu Asn Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Asn Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Glu Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Ser  Pro Arg Glu Leu Ser  Arg Val Ala 
    2915                 2920                 2925             


Ala Thr  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ala  Gln Gly Ala 
    2945                 2950                 2955             


Arg Ala  Ala Ile Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Ser  Arg Leu Asp 
    2975                 2980                 2985             


Leu Ser  Gly Trp Phe Thr Val  Gly Ala Gly Gly Gly  Gly Ile Tyr 
    2990                 2995                 3000             


His Ser  Val Ser His Ala Arg  Pro Arg Leu Leu Leu  Leu Cys Leu 
    3005                 3010                 3015             


Leu Leu  Leu Ser Val Gly Val  Gly Ile Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  126
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  126

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Arg Val Ile Asp Thr Ile Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Val Thr Val Pro Val Ser Ala Val 
            180                 185                 190         


Glu Val Arg Asn Ile Ser Ser Ser Tyr Tyr Ala Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Asn Ser Ile Thr Trp Gln Leu Thr Asp Ala Val Leu His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Asn Asp Asn Gly Thr Leu His Cys Trp Ile 
225                 230                 235                 240 


Gln Val Thr Pro Asn Val Ala Val Lys His Arg Gly Ala Leu Thr Arg 
                245                 250                 255     


Ser Leu Arg Thr His Val Asp Met Ile Val Met Ala Ala Thr Ala Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Val Cys Gly Ala Val Met Ile Leu Ser 
        275                 280                 285             


Gln Ala Phe Met Val Ser Pro Gln Arg His Asn Phe Thr Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Gln Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Leu Asn Trp Ser Pro Thr Leu Ala Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Ala Arg Val Pro Glu Met Val Leu Glu Ile Ile Phe Gly Gly His 
            340                 345                 350         


Trp Gly Val Val Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Ile Ala Ile Leu Leu Leu Val Ala Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr Tyr Ser Ser Gly Gln Glu Ala Gly Arg Thr Val Leu Gly Phe Thr 
385                 390                 395                 400 


Asn Leu Phe Thr Ser Gly Ala Lys Gln Asn Leu Tyr Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Met Ala Ser Leu Phe Tyr Thr His Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ser Ser Cys Arg Gly Leu Asp Asp 
    450                 455                 460                 


Phe Arg Ile Gly Trp Gly Thr Leu Glu Tyr Glu Thr His Val Thr Asn 
465                 470                 475                 480 


Asp Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys 
                485                 490                 495     


Gly Ile Val Pro Ala Arg Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Lys Gln Gly Val Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Arg Gly Ala Trp Phe Gly Cys Thr Trp Met Asn Gly Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Lys Asp 
                565                 570                 575     


Tyr Asn Ser Thr Ile Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Ala Thr Tyr Leu Lys Cys Gly Ala Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile Phe Lys Ala Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Phe Ser Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Arg Leu Glu Asp Arg Asp Arg Gly Gln Gln Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Val Leu Pro Cys Ser Phe Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Leu Thr Arg Tyr Ile Val Lys Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Ile Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Ile Ile Leu His Ser Ala Ser Ala Ala Ser Ala Asn Gly 
        755                 760                 765             


Pro Leu Trp Cys Phe Ile Phe Phe Thr Ala Ala Trp Tyr Leu Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Val Ala Thr Tyr Ser Val Leu Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Leu Leu Leu Val Leu Ala Leu Pro Gln Gln Ala Tyr Ala Leu Asp Ala 
                805                 810                 815     


Ala Glu Gln Gly Glu Leu Gly Leu Ala Ile Leu Val Ile Ile Ser Ile 
            820                 825                 830         


Phe Thr Leu Thr Pro Ala Tyr Lys Ile Leu Leu Ser Arg Ser Val Trp 
        835                 840                 845             


Trp Leu Ser Tyr Met Leu Val Leu Ala Glu Ala Gln Ile Gln Gln Trp 
    850                 855                 860                 


Val Pro Pro Leu Glu Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Val 
865                 870                 875                 880 


Ala Val Ile Leu His Pro Arg Leu Val Phe Glu Val Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Ile Leu Gly Pro Ala Tyr Leu Leu Lys Ala Ser Leu Leu Arg 
            900                 905                 910         


Ile Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Val Cys Thr Leu 
        915                 920                 925             


Val Lys His Leu Ala Gly Ala Arg Tyr Ile Gln Met Leu Leu Ile Thr 
    930                 935                 940                 


Ile Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Ser Pro Leu 
945                 950                 955                 960 


Ser Thr Trp Ala Ala Gln Gly Leu Arg Asp Leu Ala Ile Ala Val Glu 
                965                 970                 975     


Pro Val Val Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Val Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Lys Leu Leu  Ala Pro Ile Thr Ala  Tyr Thr Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Ala Ile Val Val Ser  Leu Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Asn Glu Gln Ala  Gly Gln Val Gln Val  Leu Ser Ser 
    1055                 1060                 1065             


Val Thr  Gln Thr Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Pro Lys 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Thr Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Asp  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Val Arg Arg Lys Asp  Asp Arg Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Ser Arg Gly His Ala  Val Gly Leu Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ala  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Ser Leu  Asp Val Thr Thr Arg  Thr Pro Ser Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Ser Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Ala Ala Tyr 
    1235                 1240                 1245             


Ala Ser  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Met Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Asp 
    1280                 1285                 1290             


Ser Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Ile Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Ala Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ser Val  Asp Ala Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Val Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Thr Val Thr  Thr Pro His Ser Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly His Glu Gly  Glu Ile Pro Phe Tyr  Gly Lys Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ala Phe Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Val Asn Ala Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Ser Gln Ile  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Val Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Ser Gly Glu  Arg Pro Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ala Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Gly Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Thr 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ala Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Ile Met  Thr Ser Ser Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Ile Ser  Ile Ile Gly Arg Leu  His Leu Asn Asp Arg  Val Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Ile Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Lys Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Met 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Thr Arg  Gln Ala Gln Asp Ile  Gln Pro Ala Ile Gln  Ser Ser Trp 
    1745                 1750                 1755             


Pro Lys  Leu Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Pro Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Met Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Ile Leu Val Asp Val  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Thr Val  Glu Asp Val Val Asn  Leu Leu Pro Ala Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Gln Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Val  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Val Leu Ser 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Ala Trp Val 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Val Pro  Cys Ser Gly Ser Trp  Leu Gln Asp 
    1970                 1975                 1980             


Ile Trp  Asp Trp Val Cys Ser  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Ser  Ser Lys Leu Leu Pro  Lys Met Pro Gly Ile  Pro Phe Ile 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Val 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly His Val 
    2030                 2035                 2040             


Arg Met  Gly Thr Met Lys Ile  Thr Gly Pro Lys Thr  Cys Leu Asn 
    2045                 2050                 2055             


Leu Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Pro 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Pro Pro  Asn Tyr Lys Thr Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Val  Glu Val Thr Gln His  Gly Ser Phe 
    2090                 2095                 2100             


Ser Tyr  Val Thr Gly Leu Thr  Ser Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Val  Pro Ala Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Val  Pro Gly Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Thr  Phe Thr Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Glu Val Leu  Ala Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Ala Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Gln Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Lys Ala Thr Cys Thr  Thr His Lys 
    2210                 2215                 2220             


Thr Ala  Tyr Asp Cys Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Asp Ser Lys Val  Ile Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Ser Met Thr  Glu Val Val Asp Asp  Arg Glu Pro 
    2255                 2260                 2265             


Ser Val  Pro Ser Glu Tyr Leu  Ile Lys Arg Arg Lys  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Pro Trp Ala Arg  Pro Asp Tyr Asn Pro  Val Leu Ile 
    2285                 2290                 2295             


Glu Thr  Trp Lys Arg Pro Gly  Tyr Glu Pro Pro Thr  Val Leu Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Thr Pro  Gln Thr Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Ala Lys Val Leu  Thr Gln Asp Asn Val  Glu Gly Ile 
    2330                 2335                 2340             


Leu Arg  Glu Met Ala Asp Lys  Val Leu Ser Pro Leu  Gln Asp Asn 
    2345                 2350                 2355             


Asn Asp  Ser Gly His Ser Thr  Gly Ala Asp Thr Gly  Gly Asp Ile 
    2360                 2365                 2370             


Val Gln  Gln Pro Ser Asp Glu  Thr Ala Ala Ser Glu  Ala Gly Ser 
    2375                 2380                 2385             


Leu Ser  Ser Met Pro Pro Leu  Glu Gly Glu Pro Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Phe Glu Pro Val Gly  Ser Ala Pro Pro Ser  Glu Gly Glu 
    2405                 2410                 2415             


Cys Glu  Val Ile Asp Ser Asp  Ser Lys Ser Trp Ser  Thr Val Ser 
    2420                 2425                 2430             


Asp Gln  Glu Asp Ser Val Ile  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Gly Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Met Arg Phe  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Ser Thr Thr Ser Arg  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Val Gln  Val Leu Asp Ala His  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Gln Asp Val Lys Arg  Ala Ala Ser Lys Val  Ser Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Val Glu Glu Ala  Cys Ala Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Lys  Ser Arg Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Arg  Arg Ala Val Asn His  Ile Arg Ser Val Trp  Glu Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Gln His Thr Pro  Ile Asp Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Ile Asp  Pro Thr Lys Gly Gly  Lys Lys Pro 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Ala Gln Lys Leu Pro  Lys Ala Ile 
    2615                 2620                 2625             


Met Gly  Pro Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Glu Arg Val 
    2630                 2635                 2640             


Asp Phe  Leu Leu Lys Ala Trp  Gly Ser Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Gln Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Gln Glu  Ala Arg Thr Val Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Thr Asn  Ser Lys Gly Gln Ser  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Phe Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Met  Thr Cys Tyr Ile Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Val Asp Pro Val Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Asn Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Leu  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Asp Ser Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Phe  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Thr  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Ile Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Leu Ala Gln Asp Thr  Leu Asn Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Asn Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Glu Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Ser  Pro Arg Glu Leu Ser  Arg Val Ala 
    2915                 2920                 2925             


Ala Thr  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ala  Gln Gly Ala 
    2945                 2950                 2955             


Arg Ala  Ala Ile Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Ser  Arg Leu Asp 
    2975                 2980                 2985             


Leu Ser  Gly Trp Phe Thr Val  Gly Ala Gly Gly Gly  Gly Ile Tyr 
    2990                 2995                 3000             


His Ser  Val Ser His Ala Arg  Pro Arg Leu Leu Leu  Leu Cys Leu 
    3005                 3010                 3015             


Leu Leu  Leu Ser Val Gly Val  Gly Ile Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  127
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  127

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Arg Val Ile Asp Thr Ile Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Val Thr Val Pro Val Ser Ala Val 
            180                 185                 190         


Glu Val Arg Asn Ile Ser Ser Ser Tyr Tyr Ala Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Asn Ser Ile Thr Trp Gln Leu Thr Asp Ala Val Leu His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Asn Asp Asn Gly Thr Leu His Cys Trp Ile 
225                 230                 235                 240 


Gln Val Thr Pro Asn Val Ala Val Lys His Arg Gly Ala Leu Thr Arg 
                245                 250                 255     


Ser Leu Arg Thr His Val Asp Met Ile Val Met Ala Ala Thr Ala Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Val Cys Gly Ala Val Met Ile Leu Ser 
        275                 280                 285             


Gln Ala Phe Met Val Ser Pro Gln Arg His Asn Phe Thr Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Gln Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Leu Asn Trp Ser Pro Thr Leu Ala Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Ala Arg Val Pro Glu Met Val Leu Glu Ile Ile Phe Gly Gly His 
            340                 345                 350         


Trp Gly Val Val Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Ile Ala Ile Leu Leu Leu Val Ala Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr Tyr Ser Ser Gly Gln Glu Ala Gly Arg Thr Val Leu Gly Phe Thr 
385                 390                 395                 400 


Asn Leu Phe Thr Ser Gly Ala Lys Gln Asn Leu Tyr Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Met Ala Ser Leu Phe Tyr Thr His Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ser Ser Cys Arg Gly Leu Asp Asp 
    450                 455                 460                 


Phe Arg Ile Gly Trp Gly Thr Leu Glu Tyr Glu Thr His Val Thr Asn 
465                 470                 475                 480 


Asp Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys 
                485                 490                 495     


Gly Ile Val Pro Ala Arg Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Lys Gln Gly Val Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Arg Gly Ala Trp Phe Gly Cys Thr Trp Met Asn Gly Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Lys Asp 
                565                 570                 575     


Tyr Asn Ser Thr Ile Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Ala Thr Tyr Leu Lys Cys Gly Ala Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile Phe Lys Ala Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Phe Ser Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Arg Leu Glu Asp Arg Asp Arg Gly Gln Gln Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Val Leu Pro Cys Ser Phe Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Leu Thr Arg Tyr Ile Val Lys Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Ile Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Ile Ile Leu His Ser Ala Ser Ala Ala Ser Ala Asn Gly 
        755                 760                 765             


Pro Leu Trp Cys Phe Ile Phe Phe Thr Ala Ala Trp Tyr Leu Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Val Ala Thr Tyr Ser Val Leu Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Leu Leu Leu Val Leu Ala Leu Pro Gln Gln Ala Tyr Ala Leu Asp Ala 
                805                 810                 815     


Ala Glu Gln Gly Glu Leu Gly Leu Ala Ile Leu Val Ile Ile Ser Ile 
            820                 825                 830         


Phe Thr Leu Thr Pro Ala Tyr Lys Ile Leu Leu Ser Arg Ser Val Trp 
        835                 840                 845             


Trp Leu Ser Tyr Met Leu Val Leu Ala Glu Ala Gln Ile Gln Gln Arg 
    850                 855                 860                 


Val Pro Pro Leu Glu Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Val 
865                 870                 875                 880 


Ala Val Ile Leu His Pro Arg Leu Val Phe Glu Val Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Ile Leu Gly Pro Ala Tyr Leu Leu Lys Ala Ser Leu Leu Arg 
            900                 905                 910         


Ile Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Val Cys Thr Leu 
        915                 920                 925             


Val Lys His Leu Ala Gly Ala Arg Tyr Ile Gln Met Leu Leu Ile Thr 
    930                 935                 940                 


Ile Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Ser Pro Leu 
945                 950                 955                 960 


Ser Thr Trp Ala Ala Gln Gly Leu Arg Asp Leu Ala Ile Ala Val Glu 
                965                 970                 975     


Pro Val Val Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Val Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Lys Leu Leu  Ala Pro Ile Thr Ala  Tyr Thr Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Ala Ile Val Val Ser  Leu Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Asn Glu Gln Ala  Gly Gln Val Gln Val  Leu Ser Ser 
    1055                 1060                 1065             


Val Thr  Gln Thr Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Pro Lys 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Thr Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Asp  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Val Arg Arg Lys Asp  Asp Arg Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Ser Arg Gly His Ala  Val Gly Leu Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ala  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Ser Leu  Asp Val Thr Thr Arg  Thr Pro Ser Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Ser Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Ala Ala Tyr 
    1235                 1240                 1245             


Ala Ser  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Met Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Asp 
    1280                 1285                 1290             


Ser Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Ile Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Ala Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ser Val  Asp Ala Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Val Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Thr Val Thr  Thr Pro His Ser Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly His Glu Gly  Glu Ile Pro Phe Tyr  Gly Lys Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ala Phe Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Val Asn Ala Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Ser Gln Ile  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Val Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Ser Gly Glu  Arg Pro Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ala Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Gly Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Thr 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ala Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Ile Met  Thr Ser Ser Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Ile Ser  Ile Ile Gly Arg Leu  His Leu Asn Asp Arg  Val Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Ile Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Lys Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Met 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Thr Arg  Gln Ala Gln Asp Ile  Gln Pro Ala Ile Gln  Ser Ser Trp 
    1745                 1750                 1755             


Pro Lys  Leu Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Pro Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Met Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Ile Leu Val Asp Val  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Thr Val  Glu Asp Val Val Asn  Leu Leu Pro Ala Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Gln Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Val  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Val Leu Ser 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Ala Trp Val 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Val Pro  Cys Ser Gly Ser Trp  Leu Gln Asp 
    1970                 1975                 1980             


Ile Trp  Asp Trp Val Cys Ser  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Ser  Ser Lys Leu Leu Pro  Lys Met Pro Gly Ile  Pro Phe Ile 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Val 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly His Val 
    2030                 2035                 2040             


Arg Met  Gly Thr Met Lys Ile  Thr Gly Pro Lys Thr  Cys Leu Asn 
    2045                 2050                 2055             


Leu Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Pro 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Pro Pro  Asn Tyr Lys Thr Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Val  Glu Val Thr Gln His  Gly Ser Phe 
    2090                 2095                 2100             


Ser Tyr  Val Thr Gly Leu Thr  Ser Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Val  Pro Ala Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Val  Pro Gly Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Thr  Phe Thr Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Glu Val Leu  Ala Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Ala Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Gln Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Lys Ala Thr Cys Thr  Thr His Lys 
    2210                 2215                 2220             


Thr Ala  Tyr Asp Cys Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Asp Ser Lys Val  Ile Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Ser Met Thr  Glu Val Glu Asp Asp  Arg Glu Pro 
    2255                 2260                 2265             


Ser Val  Pro Ser Glu Tyr Leu  Ile Lys Arg Arg Lys  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Pro Trp Ala Arg  Pro Asp Tyr Asn Pro  Val Leu Ile 
    2285                 2290                 2295             


Glu Thr  Trp Lys Arg Pro Gly  Tyr Glu Pro Pro Thr  Val Leu Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Thr Pro  Gln Thr Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Ala Lys Val Leu  Thr Gln Asp Asn Val  Glu Gly Ile 
    2330                 2335                 2340             


Leu Arg  Glu Met Ala Asp Lys  Val Leu Ser Pro Leu  Gln Asp Asn 
    2345                 2350                 2355             


Asn Asp  Ser Gly His Ser Thr  Gly Ala Asp Thr Gly  Gly Asp Ile 
    2360                 2365                 2370             


Val Gln  Gln Pro Ser Asp Glu  Thr Ala Ala Ser Glu  Ala Gly Ser 
    2375                 2380                 2385             


Leu Ser  Ser Met Pro Pro Leu  Glu Gly Glu Pro Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Phe Glu Pro Val Gly  Ser Ala Pro Pro Ser  Glu Gly Glu 
    2405                 2410                 2415             


Cys Glu  Val Ile Asp Ser Asp  Ser Lys Ser Trp Ser  Thr Val Ser 
    2420                 2425                 2430             


Asp Gln  Glu Asp Ser Val Ile  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Gly Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Met Arg Phe  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Ser Thr Thr Ser Arg  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Val Gln  Val Leu Asp Ala His  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Gln Asp Val Lys Arg  Ala Ala Ser Lys Val  Ser Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Val Glu Glu Ala  Cys Ala Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Lys  Ser Arg Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Arg  Arg Ala Val Asn His  Ile Arg Ser Val Trp  Glu Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Gln His Thr Pro  Ile Asp Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Ile Asp  Pro Thr Lys Gly Gly  Lys Lys Pro 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Ala Gln Lys Leu Pro  Lys Ala Ile 
    2615                 2620                 2625             


Met Gly  Pro Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Glu Arg Val 
    2630                 2635                 2640             


Asp Phe  Leu Leu Lys Ala Trp  Gly Ser Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Gln Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Gln Glu  Ala Arg Thr Val Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Thr Asn  Ser Lys Gly Gln Ser  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Phe Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Met  Thr Cys Tyr Ile Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Val Asp Pro Val Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Asn Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Leu  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Asp Ser Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Phe  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Thr  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Ile Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Leu Ala Gln Asp Thr  Leu Asn Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Asn Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Glu Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Ser  Pro Arg Glu Leu Ser  Arg Val Ala 
    2915                 2920                 2925             


Ala Thr  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ala  Gln Gly Ala 
    2945                 2950                 2955             


Arg Ala  Ala Ile Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Ser  Arg Leu Asp 
    2975                 2980                 2985             


Leu Ser  Gly Trp Phe Thr Val  Gly Ala Gly Gly Gly  Gly Ile Tyr 
    2990                 2995                 3000             


His Ser  Val Ser His Ala Arg  Pro Arg Leu Leu Leu  Leu Cys Leu 
    3005                 3010                 3015             


Leu Leu  Leu Ser Val Gly Val  Gly Ile Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  128
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  128

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Arg Val Ile Asp Thr Ile Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Val Thr Val Pro Val Ser Ala Val 
            180                 185                 190         


Glu Val Arg Asn Ile Ser Ser Ser Tyr Tyr Ala Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Asn Ser Ile Thr Trp Gln Leu Thr Asp Ala Val Leu His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Asn Asp Asn Gly Thr Leu His Cys Trp Ile 
225                 230                 235                 240 


Gln Val Thr Pro Asn Val Ala Val Lys His Arg Gly Ala Leu Thr Arg 
                245                 250                 255     


Ser Leu Arg Thr His Val Asp Met Ile Val Met Ala Ala Thr Ala Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Val Cys Gly Ala Val Met Ile Leu Ser 
        275                 280                 285             


Gln Ala Phe Met Val Ser Pro Gln Arg His Asn Phe Thr Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Gln Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Leu Asn Trp Ser Pro Thr Leu Ala Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Ala Arg Val Pro Glu Met Val Leu Glu Ile Ile Phe Gly Gly His 
            340                 345                 350         


Trp Gly Val Val Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Ile Ala Ile Leu Leu Leu Val Ala Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr Tyr Ser Ser Gly Gln Glu Ala Gly Arg Thr Val Leu Gly Phe Thr 
385                 390                 395                 400 


Asn Leu Phe Thr Ser Gly Ala Lys Gln Asn Leu Tyr Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Met Ala Ser Leu Phe Tyr Thr His Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ser Ser Cys Arg Gly Leu Asp Asp 
    450                 455                 460                 


Phe Arg Ile Gly Trp Gly Thr Leu Glu Tyr Glu Thr His Val Thr Asn 
465                 470                 475                 480 


Asp Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys 
                485                 490                 495     


Gly Ile Val Pro Ala Arg Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Lys Gln Gly Val Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Arg Gly Ala Trp Phe Gly Cys Thr Trp Met Asn Gly Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Lys Asp 
                565                 570                 575     


Tyr Asn Ser Thr Ile Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Ala Thr Tyr Leu Lys Cys Gly Ala Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile Phe Lys Ala Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Phe Ser Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Arg Leu Glu Asp Arg Asp Arg Gly Gln Gln Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Val Leu Pro Cys Ser Phe Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Leu Thr Arg Tyr Ile Val Lys Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Ile Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Ile Ile Leu His Ser Ala Ser Ala Ala Ser Ala Asn Gly 
        755                 760                 765             


Pro Leu Trp Cys Phe Ile Phe Phe Thr Ala Ala Trp Tyr Leu Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Val Ala Thr Tyr Ser Val Leu Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Leu Leu Leu Val Leu Ala Leu Pro Gln Gln Ala Tyr Ala Leu Asp Ala 
                805                 810                 815     


Ala Glu Gln Gly Glu Leu Gly Leu Ala Ile Leu Val Ile Ile Ser Ile 
            820                 825                 830         


Phe Thr Leu Thr Pro Ala Tyr Lys Ile Leu Leu Ser Arg Ser Val Trp 
        835                 840                 845             


Trp Leu Ser Tyr Met Leu Val Leu Ala Glu Ala Gln Ile Gln Gln Arg 
    850                 855                 860                 


Val Pro Pro Leu Glu Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Val 
865                 870                 875                 880 


Ala Val Ile Leu His Pro Arg Leu Val Phe Glu Val Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Ile Leu Gly Pro Ala Tyr Leu Leu Lys Ala Ser Leu Leu Arg 
            900                 905                 910         


Ile Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Val Cys Thr Leu 
        915                 920                 925             


Val Lys His Leu Ala Gly Ala Arg Tyr Ile Gln Met Leu Leu Ile Thr 
    930                 935                 940                 


Ile Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Ser Pro Leu 
945                 950                 955                 960 


Ser Thr Trp Ala Ala Gln Gly Leu Arg Asp Leu Ala Ile Ala Val Glu 
                965                 970                 975     


Pro Val Val Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Val Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Lys Leu Leu  Ala Pro Ile Thr Ala  Tyr Thr Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Ala Ile Val Val Ser  Leu Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Asn Glu Gln Ala  Gly Gln Val Gln Val  Leu Ser Ser 
    1055                 1060                 1065             


Val Thr  Gln Thr Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Pro Lys 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Thr Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Asp  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Val Arg Arg Lys Asp  Asp Arg Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Ser Arg Gly His Ala  Val Gly Leu Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ala  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Ser Leu  Asp Val Ala Thr Arg  Thr Pro Ser Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Ser Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Ala Ala Tyr 
    1235                 1240                 1245             


Ala Ser  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Met Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Asp 
    1280                 1285                 1290             


Ser Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Ile Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Ala Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ser Val  Asp Ala Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Val Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Thr Val Thr  Thr Pro His Ser Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly His Glu Gly  Glu Ile Pro Phe Tyr  Gly Lys Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ala Phe Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Val Asn Ala Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Ser Gln Ile  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Val Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Ser Gly Glu  Arg Pro Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ala Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Gly Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Thr 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ala Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Ile Met  Thr Ser Ser Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Ile Ser  Ile Ile Gly Arg Leu  His Leu Asn Asp Arg  Val Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Ile Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Lys Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Met 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Thr Arg  Gln Ala Gln Asp Ile  Gln Pro Ala Ile Gln  Ser Ser Trp 
    1745                 1750                 1755             


Pro Lys  Leu Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Pro Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Met Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Ile Leu Val Asp Val  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Thr Val  Glu Asp Val Val Asn  Leu Leu Pro Ala Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Gln Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Val  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Val Leu Ser 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Ala Trp Val 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Val Pro  Cys Ser Gly Ser Trp  Leu Gln Asp 
    1970                 1975                 1980             


Ile Trp  Asp Trp Val Cys Ser  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Ser  Ser Lys Leu Leu Pro  Lys Met Pro Gly Ile  Pro Phe Ile 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Val 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly His Val 
    2030                 2035                 2040             


Arg Met  Gly Thr Met Lys Ile  Thr Gly Pro Lys Thr  Cys Leu Asn 
    2045                 2050                 2055             


Leu Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Pro 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Pro Pro  Asn Tyr Lys Thr Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Val  Glu Val Thr Gln His  Gly Ser Phe 
    2090                 2095                 2100             


Ser Tyr  Val Thr Gly Leu Thr  Ser Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Val  Pro Ala Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Val  Pro Gly Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Thr  Phe Thr Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Glu Val Leu  Ala Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Ala Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Gln Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Lys Ala Thr Cys Thr  Thr His Lys 
    2210                 2215                 2220             


Thr Ala  Tyr Asp Cys Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Asp Ser Lys Val  Ile Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Ser Met Thr  Glu Val Val Asp Asp  Arg Glu Pro 
    2255                 2260                 2265             


Ser Val  Pro Ser Glu Tyr Leu  Ile Lys Arg Arg Lys  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Pro Trp Ala Arg  Pro Asp Tyr Asn Pro  Val Leu Ile 
    2285                 2290                 2295             


Glu Thr  Trp Lys Arg Pro Gly  Tyr Glu Pro Pro Thr  Val Leu Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Thr Pro  Gln Thr Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Ala Lys Val Leu  Thr Gln Asp Asn Val  Glu Gly Ile 
    2330                 2335                 2340             


Leu Arg  Glu Met Ala Asp Lys  Val Leu Ser Pro Leu  Gln Asp Asn 
    2345                 2350                 2355             


Asn Asp  Ser Gly His Ser Thr  Gly Ala Asp Thr Gly  Gly Asp Ile 
    2360                 2365                 2370             


Val Gln  Gln Pro Ser Asp Glu  Thr Ala Ala Ser Glu  Ala Gly Ser 
    2375                 2380                 2385             


Leu Ser  Ser Met Pro Pro Leu  Glu Gly Glu Pro Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Phe Glu Pro Val Gly  Ser Ala Pro Pro Ser  Glu Gly Glu 
    2405                 2410                 2415             


Cys Glu  Val Ile Asp Ser Asp  Ser Lys Ser Trp Ser  Thr Val Ser 
    2420                 2425                 2430             


Asp Gln  Glu Asp Ser Val Ile  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Gly Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Met Arg Phe  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Ser Thr Thr Ser Arg  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Val Gln  Val Leu Asp Ala His  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Gln Asp Val Lys Arg  Ala Ala Ser Lys Val  Ser Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Val Glu Glu Ala  Cys Ala Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Lys  Ser Arg Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Arg  Arg Ala Val Asn His  Ile Arg Ser Val Trp  Glu Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Gln His Thr Pro  Ile Asp Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Ile Asp  Pro Thr Lys Gly Gly  Lys Lys Pro 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Ala Gln Lys Leu Pro  Lys Ala Ile 
    2615                 2620                 2625             


Met Gly  Pro Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Glu Arg Val 
    2630                 2635                 2640             


Asp Phe  Leu Leu Lys Ala Trp  Gly Ser Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Gln Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Gln Glu  Ala Arg Thr Val Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Thr Asn  Ser Lys Gly Gln Ser  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Phe Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Met  Thr Cys Tyr Ile Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Val Asp Pro Val Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Asn Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Leu  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Asp Ser Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Phe  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Thr  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Ile Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Leu Ala Gln Asp Thr  Leu Asn Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Asn Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Glu Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Ser  Pro Arg Glu Leu Ser  Arg Val Ala 
    2915                 2920                 2925             


Ala Thr  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ala  Gln Gly Ala 
    2945                 2950                 2955             


Arg Ala  Ala Ile Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Ser  Arg Leu Asp 
    2975                 2980                 2985             


Leu Ser  Gly Trp Phe Thr Val  Gly Ala Gly Gly Gly  Gly Ile Tyr 
    2990                 2995                 3000             


His Ser  Val Ser His Ala Arg  Pro Arg Leu Leu Leu  Leu Cys Leu 
    3005                 3010                 3015             


Leu Leu  Leu Ser Val Gly Val  Gly Ile Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  129
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  129

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Arg Val Ile Asp Thr Ile Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Val Thr Val Pro Val Ser Ala Val 
            180                 185                 190         


Glu Val Arg Asn Ile Ser Ser Ser Tyr Tyr Ala Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Asn Ser Ile Thr Trp Gln Leu Thr Asp Ala Val Leu His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Asn Asp Asn Gly Thr Leu His Cys Trp Ile 
225                 230                 235                 240 


Gln Val Thr Pro Asn Val Ala Val Lys His Arg Gly Ala Leu Thr Arg 
                245                 250                 255     


Ser Leu Arg Thr His Val Asp Met Ile Val Met Ala Ala Thr Ala Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Val Cys Gly Ala Val Met Ile Leu Ser 
        275                 280                 285             


Gln Ala Phe Met Val Ser Pro Gln Arg His Asn Phe Thr Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Gln Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Leu Asn Trp Ser Pro Thr Leu Ala Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Ala Arg Val Pro Glu Met Val Leu Glu Ile Ile Phe Gly Gly His 
            340                 345                 350         


Trp Gly Val Val Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Ile Ala Ile Leu Leu Leu Val Ala Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr Tyr Ser Ser Gly Gln Glu Ala Gly Arg Thr Val Leu Gly Phe Thr 
385                 390                 395                 400 


Asn Leu Phe Thr Ser Gly Ala Lys Gln Asn Leu Tyr Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Met Ala Ser Leu Phe Tyr Thr His Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ser Ser Cys Arg Gly Leu Asp Asp 
    450                 455                 460                 


Phe Arg Ile Gly Trp Gly Thr Leu Glu Tyr Glu Thr His Val Thr Asn 
465                 470                 475                 480 


Asp Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys 
                485                 490                 495     


Gly Ile Val Pro Ala Arg Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Lys Gln Gly Val Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Arg Gly Ala Trp Phe Gly Cys Thr Trp Met Asn Gly Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Lys Asp 
                565                 570                 575     


Tyr Asn Ser Thr Ile Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Ala Thr Tyr Leu Lys Cys Gly Ala Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile Phe Lys Ala Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Phe Ser Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Arg Leu Glu Asp Arg Asp Arg Gly Gln Gln Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Val Leu Pro Cys Ser Phe Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Leu Thr Arg Tyr Ile Val Lys Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Ile Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Ile Ile Leu His Ser Ala Ser Ala Ala Ser Ala Asn Gly 
        755                 760                 765             


Pro Leu Trp Cys Phe Ile Phe Phe Thr Ala Ala Trp Tyr Leu Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Val Ala Thr Tyr Ser Val Leu Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Leu Leu Leu Val Leu Ala Leu Pro Gln Gln Ala Tyr Ala Leu Asp Ala 
                805                 810                 815     


Ala Glu Gln Gly Glu Leu Gly Leu Ala Ile Leu Val Ile Ile Ser Ile 
            820                 825                 830         


Phe Thr Leu Thr Pro Ala Tyr Lys Ile Leu Leu Ser Arg Ser Val Trp 
        835                 840                 845             


Trp Leu Ser Tyr Met Leu Val Leu Ala Glu Ala Gln Ile Gln Gln Arg 
    850                 855                 860                 


Val Pro Pro Leu Glu Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Val 
865                 870                 875                 880 


Ala Val Ile Leu His Pro Arg Leu Val Phe Glu Val Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Ile Leu Gly Pro Ala Tyr Leu Leu Lys Ala Ser Leu Leu Arg 
            900                 905                 910         


Ile Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Val Cys Thr Leu 
        915                 920                 925             


Val Lys His Leu Ala Gly Ala Arg Tyr Ile Gln Met Leu Leu Ile Thr 
    930                 935                 940                 


Ile Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Ser Pro Leu 
945                 950                 955                 960 


Ser Thr Trp Ala Ala Gln Gly Leu Arg Asp Leu Ala Ile Ala Val Glu 
                965                 970                 975     


Pro Val Val Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Val Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Lys Leu Leu  Ala Pro Ile Thr Ala  Tyr Thr Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Ala Ile Val Val Ser  Leu Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Asn Glu Gln Ala  Gly Gln Val Gln Val  Leu Ser Ser 
    1055                 1060                 1065             


Val Thr  Gln Thr Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Pro Lys 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Thr Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Asp  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Val Arg Arg Lys Asp  Asp Arg Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Ser Arg Gly His Ala  Val Gly Leu Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ala  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Ser Leu  Asp Val Ala Thr Arg  Thr Pro Ser Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Ser Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Ala Ala Tyr 
    1235                 1240                 1245             


Ala Ser  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Met Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Asp 
    1280                 1285                 1290             


Ser Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Ile Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Ala Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ser Val  Asp Ala Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Val Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Thr Val Thr  Thr Pro His Ser Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly His Glu Gly  Glu Ile Pro Phe Tyr  Gly Lys Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ala Phe Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Val Asn Ala Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Ser Gln Ile  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Val Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Ser Gly Glu  Arg Pro Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ala Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Gly Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Thr 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ala Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Ile Met  Thr Ser Ser Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Ile Ser  Ile Ile Gly Arg Leu  His Leu Asn Asp Arg  Val Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Ile Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Lys Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Met 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Thr Arg  Gln Ala Gln Asp Ile  Gln Pro Ala Ile Gln  Ser Ser Trp 
    1745                 1750                 1755             


Pro Lys  Leu Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Pro Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Met Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Ile Leu Val Asp Val  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Thr Val  Glu Asp Val Val Asn  Leu Leu Pro Ala Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Gln Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Val  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Val Leu Ser 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Ala Trp Val 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Val Pro  Cys Ser Gly Ser Trp  Leu Gln Asp 
    1970                 1975                 1980             


Ile Trp  Asp Trp Val Cys Ser  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Ser  Ser Lys Leu Leu Pro  Lys Met Pro Gly Ile  Pro Phe Ile 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Val 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly His Val 
    2030                 2035                 2040             


Arg Met  Gly Thr Met Lys Ile  Thr Gly Pro Lys Thr  Cys Leu Asn 
    2045                 2050                 2055             


Leu Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Pro 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Pro Pro  Asn Tyr Lys Thr Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Val  Glu Val Thr Gln His  Gly Ser Phe 
    2090                 2095                 2100             


Ser Tyr  Val Thr Gly Leu Thr  Ser Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Val  Pro Ala Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Val  Pro Gly Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Thr  Phe Thr Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Glu Val Leu  Ala Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Ala Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Gln Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Lys Ala Thr Cys Thr  Thr His Lys 
    2210                 2215                 2220             


Thr Ala  Tyr Asp Cys Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Asp Ser Lys Val  Ile Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Ser Met Thr  Glu Val Glu Asp Asp  Arg Glu Pro 
    2255                 2260                 2265             


Ser Val  Pro Ser Glu Tyr Leu  Ile Lys Arg Arg Lys  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Pro Trp Ala Arg  Pro Asp Tyr Asn Pro  Val Leu Ile 
    2285                 2290                 2295             


Glu Thr  Trp Lys Arg Pro Gly  Tyr Glu Pro Pro Thr  Val Leu Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Thr Pro  Gln Thr Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Ala Lys Val Leu  Thr Gln Asp Asn Val  Glu Gly Ile 
    2330                 2335                 2340             


Leu Arg  Glu Met Ala Asp Lys  Val Leu Ser Pro Leu  Gln Asp Asn 
    2345                 2350                 2355             


Asn Asp  Ser Gly His Ser Thr  Gly Ala Asp Thr Gly  Gly Asp Ile 
    2360                 2365                 2370             


Val Gln  Gln Pro Ser Asp Glu  Thr Ala Ala Ser Glu  Ala Gly Ser 
    2375                 2380                 2385             


Leu Ser  Ser Met Pro Pro Leu  Glu Gly Glu Pro Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Phe Glu Pro Val Gly  Ser Ala Pro Pro Ser  Glu Gly Glu 
    2405                 2410                 2415             


Cys Glu  Val Ile Asp Ser Asp  Ser Lys Ser Trp Ser  Thr Val Ser 
    2420                 2425                 2430             


Asp Gln  Glu Asp Ser Val Ile  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Gly Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Met Arg Phe  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Ser Thr Thr Ser Arg  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Val Gln  Val Leu Asp Ala His  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Gln Asp Val Lys Arg  Ala Ala Ser Lys Val  Ser Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Val Glu Glu Ala  Cys Ala Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Lys  Ser Arg Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Arg  Arg Ala Val Asn His  Ile Arg Ser Val Trp  Glu Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Gln His Thr Pro  Ile Asp Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Ile Asp  Pro Thr Lys Gly Gly  Lys Lys Pro 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Ala Gln Lys Leu Pro  Lys Ala Ile 
    2615                 2620                 2625             


Met Gly  Pro Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Glu Arg Val 
    2630                 2635                 2640             


Asp Phe  Leu Leu Lys Ala Trp  Gly Ser Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Gln Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Gln Glu  Ala Arg Thr Val Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Thr Asn  Ser Lys Gly Gln Ser  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Phe Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Met  Thr Cys Tyr Ile Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Val Asp Pro Val Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Asn Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Leu  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Asp Ser Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Phe  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Thr  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Ile Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Leu Ala Gln Asp Thr  Leu Asn Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Asn Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Glu Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Ser  Pro Arg Glu Leu Ser  Arg Val Ala 
    2915                 2920                 2925             


Ala Thr  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ala  Gln Gly Ala 
    2945                 2950                 2955             


Arg Ala  Ala Ile Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Ser  Arg Leu Asp 
    2975                 2980                 2985             


Leu Ser  Gly Trp Phe Thr Val  Gly Ala Gly Gly Gly  Gly Ile Tyr 
    2990                 2995                 3000             


His Ser  Val Ser His Ala Arg  Pro Arg Leu Leu Leu  Leu Cys Leu 
    3005                 3010                 3015             


Leu Leu  Leu Ser Val Gly Val  Gly Ile Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  130
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  130

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Arg Val Ile Asp Thr Ile Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Val Thr Val Pro Val Ser Ala Val 
            180                 185                 190         


Glu Val Arg Asn Ile Ser Ser Ser Tyr Tyr Ala Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Asn Ser Ile Thr Trp Gln Leu Thr Asp Ala Val Leu His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Asn Asp Asn Gly Thr Leu His Cys Trp Ile 
225                 230                 235                 240 


Gln Val Thr Pro Asn Val Ala Val Lys His Arg Gly Ala Leu Thr Arg 
                245                 250                 255     


Ser Leu Arg Thr His Val Asp Met Ile Val Met Ala Ala Thr Ala Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Val Cys Gly Ala Val Met Ile Leu Ser 
        275                 280                 285             


Gln Ala Phe Met Val Ser Pro Gln Arg His Asn Phe Thr Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Gln Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Leu Asn Trp Ser Pro Thr Leu Ala Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Ala Arg Val Pro Glu Met Val Leu Glu Ile Ile Phe Gly Gly His 
            340                 345                 350         


Trp Gly Val Val Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Ile Ala Ile Leu Leu Leu Val Ala Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr Tyr Ser Ser Gly Gln Glu Ala Gly Arg Thr Val Leu Gly Phe Thr 
385                 390                 395                 400 


Asn Leu Phe Thr Ser Gly Ala Lys Gln Asn Leu Tyr Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Met Ala Ser Leu Phe Tyr Thr His Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ser Ser Cys Arg Gly Leu Asp Asp 
    450                 455                 460                 


Phe Arg Ile Gly Trp Gly Thr Leu Glu Tyr Glu Thr His Val Thr Asn 
465                 470                 475                 480 


Asp Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys 
                485                 490                 495     


Gly Ile Val Pro Ala Arg Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Lys Gln Gly Val Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Arg Gly Ala Trp Phe Gly Cys Thr Trp Met Asn Gly Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Lys Asp 
                565                 570                 575     


Tyr Asn Ser Thr Ile Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Ala Thr Tyr Leu Lys Cys Gly Ala Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile Phe Lys Ala Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Phe Ser Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Arg Leu Glu Asp Arg Asp Arg Gly Gln Gln Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Val Leu Pro Cys Ser Phe Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Leu Thr Arg Tyr Ile Val Lys Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Ile Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Ile Ile Leu His Ser Ala Ser Ala Ala Ser Ala Asn Gly 
        755                 760                 765             


Pro Leu Trp Cys Phe Ile Phe Phe Thr Ala Ala Trp Tyr Leu Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Val Ala Thr Tyr Ser Val Leu Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Leu Leu Leu Val Leu Ala Leu Pro Gln Gln Ala Tyr Ala Leu Asp Ala 
                805                 810                 815     


Ala Glu Gln Gly Glu Leu Gly Leu Ala Ile Leu Val Ile Ile Ser Ile 
            820                 825                 830         


Phe Thr Leu Thr Pro Ala Tyr Lys Ile Leu Leu Ser Arg Ser Val Trp 
        835                 840                 845             


Trp Leu Ser Tyr Met Leu Val Leu Ala Glu Ala Gln Ile Gln Gln Arg 
    850                 855                 860                 


Val Pro Pro Leu Glu Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Val 
865                 870                 875                 880 


Ala Val Ile Leu His Pro Arg Leu Val Phe Glu Val Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Ile Leu Gly Pro Ala Tyr Leu Leu Lys Ala Ser Leu Leu Arg 
            900                 905                 910         


Ile Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Val Cys Thr Leu 
        915                 920                 925             


Val Lys His Leu Ala Gly Ala Arg Tyr Ile Gln Met Leu Leu Ile Thr 
    930                 935                 940                 


Ile Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Ser Pro Leu 
945                 950                 955                 960 


Ser Thr Trp Ala Ala Gln Gly Leu Arg Asp Leu Ala Ile Ala Val Glu 
                965                 970                 975     


Pro Val Val Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Val Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Lys Leu Leu  Ala Pro Ile Thr Ala  Tyr Thr Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Ala Ile Val Val Ser  Leu Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Asn Glu Gln Ala  Gly Gln Val Gln Val  Leu Ser Ser 
    1055                 1060                 1065             


Val Thr  Gln Thr Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Pro Lys 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Thr Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Asp  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Val Arg Arg Lys Asp  Asp Arg Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Ser Arg Gly His Ala  Val Gly Leu Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ala  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Ser Leu  Asp Val Thr Thr Arg  Thr Pro Ser Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Ser Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Ala Ala Tyr 
    1235                 1240                 1245             


Ala Ser  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Met Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Thr  Thr Gly Asp 
    1280                 1285                 1290             


Ser Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Ile Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Ala Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ser Val  Asp Ala Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Val Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Thr Val Thr  Thr Pro His Ser Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly His Glu Gly  Glu Ile Pro Phe Tyr  Gly Lys Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ala Phe Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Val Asn Ala Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Ser Gln Ile  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Val Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Ser Gly Glu  Arg Pro Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ala Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Gly Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Thr 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ala Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Ile Met  Thr Ser Ser Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Ile Ser  Ile Ile Gly Arg Leu  His Leu Asn Asp Arg  Val Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Ile Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Lys Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Met 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Thr Arg  Gln Ala Gln Asp Ile  Gln Pro Ala Ile Gln  Ser Ser Trp 
    1745                 1750                 1755             


Pro Lys  Leu Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Pro Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Met Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Ile Leu Val Asp Val  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Thr Val  Glu Asp Val Val Asn  Leu Leu Pro Ala Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Gln Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Val  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Val Leu Ser 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Ala Trp Val 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Val Pro  Cys Ser Gly Ser Trp  Leu Gln Asp 
    1970                 1975                 1980             


Ile Trp  Asp Trp Val Cys Ser  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Ser  Ser Lys Leu Leu Pro  Lys Met Pro Gly Ile  Pro Phe Ile 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Val 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly His Val 
    2030                 2035                 2040             


Arg Met  Gly Thr Met Lys Ile  Thr Gly Pro Lys Thr  Cys Leu Asn 
    2045                 2050                 2055             


Leu Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Pro 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Pro Pro  Asn Tyr Lys Thr Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Val  Glu Val Thr Gln His  Gly Ser Phe 
    2090                 2095                 2100             


Ser Tyr  Val Thr Gly Leu Thr  Ser Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Val  Pro Ala Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Val  Pro Gly Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Thr  Phe Thr Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Glu Val Leu  Ala Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Ala Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Gln Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Lys Ala Thr Cys Thr  Thr His Lys 
    2210                 2215                 2220             


Thr Ala  Tyr Asp Cys Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Asp Ser Lys Val  Ile Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Ser Met Thr  Glu Val Val Asp Asp  Arg Glu Pro 
    2255                 2260                 2265             


Ser Val  Pro Ser Glu Tyr Leu  Ile Lys Arg Arg Lys  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Pro Trp Ala Arg  Pro Asp Tyr Asn Pro  Val Leu Ile 
    2285                 2290                 2295             


Glu Thr  Trp Lys Arg Pro Gly  Tyr Glu Pro Pro Thr  Val Leu Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Thr Pro  Gln Thr Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Ala Lys Val Leu  Thr Gln Asp Asn Val  Glu Gly Ile 
    2330                 2335                 2340             


Leu Arg  Glu Met Ala Asp Lys  Val Leu Ser Pro Leu  Gln Asp Asn 
    2345                 2350                 2355             


Asn Asp  Ser Gly His Ser Thr  Gly Ala Asp Thr Gly  Gly Asp Ile 
    2360                 2365                 2370             


Val Gln  Gln Pro Ser Asp Glu  Thr Ala Ala Ser Glu  Ala Gly Ser 
    2375                 2380                 2385             


Leu Ser  Ser Met Pro Pro Leu  Glu Gly Glu Pro Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Phe Glu Pro Val Gly  Ser Ala Pro Pro Ser  Glu Gly Glu 
    2405                 2410                 2415             


Cys Glu  Val Ile Asp Ser Asp  Ser Lys Ser Trp Ser  Thr Val Ser 
    2420                 2425                 2430             


Asp Gln  Glu Asp Ser Val Ile  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Gly Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Met Arg Phe  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Ser Thr Thr Ser Arg  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Val Gln  Val Leu Asp Ala His  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Gln Asp Val Lys Arg  Ala Ala Ser Lys Val  Ser Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Val Glu Glu Ala  Cys Ala Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Lys  Ser Arg Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Arg  Arg Ala Val Asn His  Ile Arg Ser Val Trp  Glu Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Gln His Thr Pro  Ile Asp Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Ile Asp  Pro Thr Lys Gly Gly  Lys Lys Pro 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Ala Gln Lys Leu Pro  Lys Ala Ile 
    2615                 2620                 2625             


Met Gly  Pro Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Glu Arg Val 
    2630                 2635                 2640             


Asp Phe  Leu Leu Lys Ala Trp  Gly Ser Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Gln Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Gln Glu  Ala Arg Thr Val Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Thr Asn  Ser Lys Gly Gln Ser  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Phe Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Met  Thr Cys Tyr Ile Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Val Asp Pro Val Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Asn Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Leu  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Asp Ser Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Phe  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Thr  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Ile Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Leu Ala Gln Asp Thr  Leu Asn Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Ser Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Glu Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Ser  Pro Arg Glu Leu Ser  Arg Val Ala 
    2915                 2920                 2925             


Ala Thr  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ala  Gln Gly Ala 
    2945                 2950                 2955             


Arg Ala  Ala Ile Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Ser  Arg Leu Asp 
    2975                 2980                 2985             


Leu Ser  Gly Trp Phe Thr Val  Gly Ala Gly Gly Gly  Gly Ile Tyr 
    2990                 2995                 3000             


His Ser  Val Ser His Ala Arg  Pro Arg Leu Leu Leu  Leu Cys Leu 
    3005                 3010                 3015             


Leu Leu  Leu Ser Val Gly Val  Gly Ile Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  131
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  131

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Arg Val Ile Asp Thr Ile Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Val Thr Val Pro Val Ser Ala Val 
            180                 185                 190         


Glu Val Arg Asn Ile Ser Ser Ser Tyr Tyr Ala Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Asn Ser Ile Thr Trp Gln Leu Thr Asp Ala Val Leu His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Asn Asp Asn Gly Thr Leu His Cys Trp Ile 
225                 230                 235                 240 


Gln Val Thr Pro Asn Val Ala Val Lys His Arg Gly Ala Leu Thr Arg 
                245                 250                 255     


Ser Leu Arg Thr His Val Asp Met Ile Val Met Ala Ala Thr Ala Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Val Cys Gly Ala Val Met Ile Leu Ser 
        275                 280                 285             


Gln Ala Phe Met Val Ser Pro Gln Arg His Asn Phe Thr Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Gln Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Leu Asn Trp Ser Pro Thr Leu Ala Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Ala Arg Val Pro Glu Met Val Leu Glu Ile Ile Phe Gly Gly His 
            340                 345                 350         


Trp Gly Val Val Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Ile Ala Ile Leu Leu Leu Val Ala Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr Tyr Ser Ser Gly Gln Glu Ala Gly Arg Thr Val Leu Gly Phe Thr 
385                 390                 395                 400 


Asn Leu Phe Thr Ser Gly Ala Lys Gln Asn Leu Tyr Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Met Ala Ser Leu Phe Tyr Thr His Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ser Ser Cys Arg Gly Leu Asp Asp 
    450                 455                 460                 


Phe Arg Ile Gly Trp Gly Thr Leu Glu Tyr Glu Thr His Val Thr Asn 
465                 470                 475                 480 


Asp Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys 
                485                 490                 495     


Gly Ile Val Pro Ala Arg Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Lys Gln Gly Val Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Arg Gly Ala Trp Phe Gly Cys Thr Trp Met Asn Gly Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Lys Asp 
                565                 570                 575     


Tyr Asn Ser Thr Ile Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Ala Thr Tyr Leu Lys Cys Gly Ala Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile Phe Lys Ala Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Phe Ser Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Arg Leu Glu Asp Arg Asp Arg Gly Gln Gln Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Val Leu Pro Cys Ser Phe Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Leu Thr Arg Tyr Ile Val Lys Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Ile Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Ile Ile Leu His Ser Ala Ser Ala Ala Ser Ala Asn Gly 
        755                 760                 765             


Pro Leu Trp Cys Phe Ile Phe Phe Thr Ala Ala Trp Tyr Leu Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Val Ala Thr Tyr Ser Val Leu Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Leu Leu Leu Val Leu Ala Leu Pro Gln Gln Ala Tyr Ala Leu Asp Ala 
                805                 810                 815     


Ala Glu Gln Gly Glu Leu Gly Leu Ala Ile Leu Val Ile Ile Ser Ile 
            820                 825                 830         


Phe Thr Leu Thr Pro Ala Tyr Lys Ile Leu Leu Ser Arg Ser Val Trp 
        835                 840                 845             


Trp Leu Ser Tyr Met Leu Val Leu Ala Glu Ala Gln Ile Gln Gln Arg 
    850                 855                 860                 


Val Pro Pro Leu Glu Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Val 
865                 870                 875                 880 


Ala Val Ile Leu His Pro Arg Leu Val Phe Glu Val Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Ile Leu Gly Pro Ala Tyr Leu Leu Lys Ala Ser Leu Leu Arg 
            900                 905                 910         


Ile Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Val Cys Thr Leu 
        915                 920                 925             


Val Lys His Leu Ala Gly Ala Arg Tyr Ile Gln Met Leu Leu Ile Thr 
    930                 935                 940                 


Ile Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Ser Pro Leu 
945                 950                 955                 960 


Ser Thr Trp Ala Ala Gln Gly Leu Arg Asp Leu Ala Ile Ala Val Glu 
                965                 970                 975     


Pro Val Val Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Val Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Lys Leu Leu  Ala Pro Ile Thr Ala  Tyr Thr Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Ala Ile Val Val Ser  Leu Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Asn Glu Gln Ala  Gly Gln Val Gln Val  Leu Ser Ser 
    1055                 1060                 1065             


Val Thr  Gln Thr Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Pro Lys 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Thr Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Asp  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Val Arg Arg Lys Asp  Asp Arg Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Ser Arg Gly His Ala  Val Gly Leu Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ala  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Ser Leu  Asp Val Thr Thr Arg  Thr Pro Ser Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Ser Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Ala Ala Tyr 
    1235                 1240                 1245             


Ala Ser  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Met Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Ala  Thr Gly Asp 
    1280                 1285                 1290             


Ser Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Ile Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Ala Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ser Val  Asp Ala Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Val Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Thr Val Thr  Thr Pro His Ser Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly His Glu Gly  Glu Ile Pro Phe Tyr  Gly Lys Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ala Phe Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Val Asn Ala Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Ser Gln Ile  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Val Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Ser Gly Glu  Arg Pro Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ala Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Gly Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Thr 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ala Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Ile Met  Thr Ser Ser Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Ile Ser  Ile Ile Gly Arg Leu  His Leu Asn Asp Arg  Val Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Ile Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Lys Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Met 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Thr Arg  Gln Ala Gln Asp Ile  Gln Pro Ala Ile Gln  Ser Ser Trp 
    1745                 1750                 1755             


Pro Lys  Leu Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Pro Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Met Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Ile Leu Val Asp Val  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Thr Val  Glu Asp Val Val Asn  Leu Leu Pro Ala Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Gln Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Val  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Val Leu Ser 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Ala Trp Val 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Val Pro  Cys Ser Gly Ser Trp  Leu Gln Asp 
    1970                 1975                 1980             


Ile Trp  Asp Trp Val Cys Ser  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Ser  Ser Lys Leu Leu Pro  Lys Met Pro Gly Ile  Pro Phe Ile 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Val 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly His Val 
    2030                 2035                 2040             


Arg Met  Gly Thr Met Lys Ile  Thr Gly Pro Lys Thr  Cys Leu Asn 
    2045                 2050                 2055             


Leu Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Pro 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Pro Pro  Asn Tyr Lys Thr Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Val  Glu Val Thr Gln His  Gly Ser Phe 
    2090                 2095                 2100             


Ser Tyr  Val Thr Gly Leu Thr  Ser Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Val  Pro Ala Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Val  Pro Gly Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Thr  Phe Thr Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Glu Val Leu  Ala Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Ala Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Gln Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Lys Ala Thr Cys Thr  Thr His Lys 
    2210                 2215                 2220             


Thr Ala  Tyr Asp Cys Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Asp Ser Lys Val  Ile Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Ser Met Thr  Glu Val Glu Asp Asp  Arg Glu Pro 
    2255                 2260                 2265             


Ser Val  Pro Ser Glu Tyr Leu  Ile Lys Arg Arg Lys  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Pro Trp Ala Arg  Pro Asp Tyr Asn Pro  Val Leu Ile 
    2285                 2290                 2295             


Glu Thr  Trp Lys Arg Pro Gly  Tyr Glu Pro Pro Thr  Val Leu Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Thr Pro  Gln Thr Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Ala Lys Val Leu  Thr Gln Asp Asn Val  Glu Gly Ile 
    2330                 2335                 2340             


Leu Arg  Glu Met Ala Asp Lys  Val Leu Ser Pro Leu  Gln Asp Asn 
    2345                 2350                 2355             


Asn Asp  Ser Gly His Ser Thr  Gly Ala Asp Thr Gly  Gly Asp Ile 
    2360                 2365                 2370             


Val Gln  Gln Pro Ser Asp Glu  Thr Ala Ala Ser Glu  Ala Gly Ser 
    2375                 2380                 2385             


Leu Ser  Ser Met Pro Pro Leu  Glu Gly Glu Pro Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Phe Glu Pro Val Gly  Ser Ala Pro Pro Ser  Glu Gly Glu 
    2405                 2410                 2415             


Cys Glu  Val Ile Asp Ser Asp  Ser Lys Ser Trp Ser  Thr Val Ser 
    2420                 2425                 2430             


Asp Gln  Glu Asp Ser Val Ile  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Gly Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Met Arg Phe  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Ser Thr Thr Ser Arg  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Val Gln  Val Leu Asp Ala His  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Gln Asp Val Lys Arg  Ala Ala Ser Lys Val  Ser Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Val Glu Glu Ala  Cys Ala Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Lys  Ser Arg Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Arg  Arg Ala Val Asn His  Ile Arg Ser Val Trp  Glu Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Gln His Thr Pro  Ile Asp Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Ile Asp  Pro Thr Lys Gly Gly  Lys Lys Pro 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Ala Gln Lys Leu Pro  Lys Ala Ile 
    2615                 2620                 2625             


Met Gly  Pro Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Glu Arg Val 
    2630                 2635                 2640             


Asp Phe  Leu Leu Lys Ala Trp  Gly Ser Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Gln Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Gln Glu  Ala Arg Thr Val Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Thr Asn  Ser Lys Gly Gln Ser  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Phe Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Met  Thr Cys Tyr Ile Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Val Asp Pro Val Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Asn Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Leu  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Asp Ser Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Phe  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Thr  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Ile Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Leu Ala Gln Asp Thr  Leu Asn Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Asn Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Glu Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Ser  Pro Arg Glu Leu Ser  Arg Val Ala 
    2915                 2920                 2925             


Ala Thr  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ala  Gln Gly Ala 
    2945                 2950                 2955             


Arg Ala  Ala Ile Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Ser  Arg Leu Asp 
    2975                 2980                 2985             


Leu Ser  Gly Trp Phe Thr Val  Gly Ala Gly Gly Gly  Gly Ile Tyr 
    2990                 2995                 3000             


His Ser  Val Ser His Ala Arg  Pro Arg Leu Leu Leu  Leu Cys Leu 
    3005                 3010                 3015             


Leu Leu  Leu Ser Val Gly Val  Gly Ile Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  132
<211>  3033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Plasmid

<400>  132

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Asp Arg Arg Ser Thr Gly Lys Ser Trp Gly Lys Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg His Arg Ser Arg Asn Leu Gly Arg Val Ile Asp Thr Ile Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Val Thr Val Pro Val Ser Ala Val 
            180                 185                 190         


Glu Val Arg Asn Ile Ser Ser Ser Tyr Tyr Ala Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Asn Ser Ile Thr Trp Gln Leu Thr Asp Ala Val Leu His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Glu Asn Asp Asn Gly Thr Leu His Cys Trp Ile 
225                 230                 235                 240 


Gln Val Thr Pro Asn Val Ala Val Lys His Arg Gly Ala Leu Thr Arg 
                245                 250                 255     


Ser Leu Arg Thr His Val Asp Met Ile Val Met Ala Ala Thr Ala Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Val Cys Gly Ala Val Met Ile Leu Ser 
        275                 280                 285             


Gln Ala Phe Met Val Ser Pro Gln Arg His Asn Phe Thr Gln Glu Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Gln Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Leu Asn Trp Ser Pro Thr Leu Ala Met Ile Leu Ala Tyr 
                325                 330                 335     


Ala Ala Arg Val Pro Glu Met Val Leu Glu Ile Ile Phe Gly Gly His 
            340                 345                 350         


Trp Gly Val Val Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 
        355                 360                 365             


Ala Lys Val Ile Ala Ile Leu Leu Leu Val Ala Gly Val Asp Ala Thr 
    370                 375                 380                 


Thr Tyr Ser Ser Gly Gln Glu Ala Gly Arg Thr Val Leu Gly Phe Thr 
385                 390                 395                 400 


Asn Leu Phe Thr Ser Gly Ala Lys Gln Asn Leu Tyr Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Gln Thr Gly Phe Met Ala Ser Leu Phe Tyr Thr His Arg Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ser Ser Cys Arg Gly Leu Asp Asp 
    450                 455                 460                 


Phe Arg Ile Gly Trp Gly Thr Leu Glu Tyr Glu Thr His Val Thr Asn 
465                 470                 475                 480 


Asp Glu Asp Met Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys 
                485                 490                 495     


Gly Ile Val Pro Ala Arg Thr Val Cys Gly Pro Val Tyr Cys Phe Thr 
            500                 505                 510         


Pro Ser Pro Val Val Val Gly Thr Thr Asp Lys Gln Gly Val Pro Thr 
        515                 520                 525             


Tyr Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr 
    530                 535                 540                 


Arg Pro Pro Arg Gly Ala Trp Phe Gly Cys Thr Trp Met Asn Gly Thr 
545                 550                 555                 560 


Gly Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Arg Ile Arg Lys Asp 
                565                 570                 575     


Tyr Asn Ser Thr Ile Asp Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys 
            580                 585                 590         


His Pro Asp Ala Thr Tyr Leu Lys Cys Gly Ala Gly Pro Trp Leu Thr 
        595                 600                 605             


Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
    610                 615                 620                 


Thr Val Asn Phe Thr Ile Phe Lys Ala Arg Met Tyr Val Gly Gly Val 
625                 630                 635                 640 


Glu His Arg Phe Ser Ala Ala Cys Asn Phe Thr Arg Gly Asp Arg Cys 
                645                 650                 655     


Arg Leu Glu Asp Arg Asp Arg Gly Gln Gln Ser Pro Leu Leu His Ser 
            660                 665                 670         


Thr Thr Glu Trp Ala Val Leu Pro Cys Ser Phe Ser Asp Leu Pro Ala 
        675                 680                 685             


Leu Ser Thr Gly Leu Leu His Leu His Gln Asn Ile Val Asp Val Gln 
    690                 695                 700                 


Tyr Leu Tyr Gly Leu Ser Pro Ala Leu Thr Arg Tyr Ile Val Lys Trp 
705                 710                 715                 720 


Glu Trp Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys 
                725                 730                 735     


Ala Cys Leu Trp Met Leu Ile Ile Leu Gly Gln Ala Glu Ala Ala Leu 
            740                 745                 750         


Glu Lys Leu Ile Ile Leu His Ser Ala Ser Ala Ala Ser Ala Asn Gly 
        755                 760                 765             


Pro Leu Trp Cys Phe Ile Phe Phe Thr Ala Ala Trp Tyr Leu Lys Gly 
    770                 775                 780                 


Arg Val Val Pro Val Ala Thr Tyr Ser Val Leu Gly Leu Trp Ser Phe 
785                 790                 795                 800 


Leu Leu Leu Val Leu Ala Leu Pro Gln Gln Ala Tyr Ala Leu Asp Ala 
                805                 810                 815     


Ala Glu Gln Gly Glu Leu Gly Leu Ala Ile Leu Val Ile Ile Ser Ile 
            820                 825                 830         


Phe Thr Leu Thr Pro Ala Tyr Lys Ile Leu Leu Ser Arg Ser Val Trp 
        835                 840                 845             


Trp Leu Ser Tyr Met Leu Val Leu Ala Glu Ala Gln Ile Gln Gln Arg 
    850                 855                 860                 


Val Pro Pro Leu Glu Val Arg Gly Gly Arg Asp Gly Ile Ile Trp Val 
865                 870                 875                 880 


Ala Val Ile Leu His Pro Arg Leu Val Phe Glu Val Thr Lys Trp Leu 
                885                 890                 895     


Leu Ala Ile Leu Gly Pro Ala Tyr Leu Leu Lys Ala Ser Leu Leu Arg 
            900                 905                 910         


Ile Pro Tyr Phe Val Arg Ala His Ala Leu Leu Arg Val Cys Thr Leu 
        915                 920                 925             


Val Lys His Leu Ala Gly Ala Arg Tyr Ile Gln Met Leu Leu Ile Thr 
    930                 935                 940                 


Ile Gly Arg Trp Thr Gly Thr Tyr Ile Tyr Asp His Leu Ser Pro Leu 
945                 950                 955                 960 


Ser Thr Trp Ala Ala Gln Gly Leu Arg Asp Leu Ala Ile Ala Val Glu 
                965                 970                 975     


Pro Val Val Phe Ser Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala 
            980                 985                 990         


Glu Thr Val Ala Cys Gly Asp Ile  Leu His Gly Leu Pro  Val Ser Ala 
        995                 1000                 1005             


Arg Leu  Gly Arg Glu Val Leu  Leu Gly Pro Ala Asp  Gly Tyr Thr 
    1010                 1015                 1020             


Ser Lys  Gly Trp Lys Leu Leu  Ala Pro Ile Thr Ala  Tyr Thr Gln 
    1025                 1030                 1035             


Gln Thr  Arg Gly Leu Leu Gly  Ala Ile Val Val Ser  Leu Thr Gly 
    1040                 1045                 1050             


Arg Asp  Lys Asn Glu Gln Ala  Gly Gln Val Gln Val  Leu Ser Ser 
    1055                 1060                 1065             


Val Thr  Gln Thr Phe Leu Gly  Thr Ser Ile Ser Gly  Val Leu Trp 
    1070                 1075                 1080             


Thr Val  Tyr His Gly Ala Gly  Asn Lys Thr Leu Ala  Gly Pro Lys 
    1085                 1090                 1095             


Gly Pro  Val Thr Gln Met Tyr  Thr Ser Ala Glu Gly  Asp Leu Val 
    1100                 1105                 1110             


Gly Trp  Pro Ser Pro Pro Gly  Thr Lys Ser Leu Asp  Pro Cys Thr 
    1115                 1120                 1125             


Cys Gly  Ala Val Asp Leu Tyr  Leu Val Thr Arg Asn  Ala Asp Val 
    1130                 1135                 1140             


Ile Pro  Val Arg Arg Lys Asp  Asp Arg Arg Gly Ala  Leu Leu Ser 
    1145                 1150                 1155             


Pro Arg  Pro Leu Ser Thr Leu  Lys Gly Ser Ser Gly  Gly Pro Val 
    1160                 1165                 1170             


Leu Cys  Ser Arg Gly His Ala  Val Gly Leu Phe Arg  Ala Ala Val 
    1175                 1180                 1185             


Cys Ala  Arg Gly Val Ala Lys  Ser Ile Asp Phe Ile  Pro Val Glu 
    1190                 1195                 1200             


Ser Leu  Asp Val Thr Thr Arg  Thr Pro Ser Phe Ser  Asp Asn Ser 
    1205                 1210                 1215             


Thr Pro  Pro Ala Val Pro Gln  Ser Tyr Gln Val Gly  Tyr Leu His 
    1220                 1225                 1230             


Ala Pro  Thr Gly Ser Gly Lys  Ser Thr Lys Val Pro  Ala Ala Tyr 
    1235                 1240                 1245             


Ala Ser  Gln Gly Tyr Lys Val  Leu Val Leu Asn Pro  Ser Val Ala 
    1250                 1255                 1260             


Ala Thr  Leu Gly Phe Gly Ala  Tyr Met Ser Lys Ala  His Gly Ile 
    1265                 1270                 1275             


Asn Pro  Asn Ile Arg Thr Gly  Val Arg Thr Val Ala  Thr Gly Asp 
    1280                 1285                 1290             


Ser Ile  Thr Tyr Ser Thr Tyr  Gly Lys Phe Ile Ala  Asp Gly Gly 
    1295                 1300                 1305             


Cys Ala  Ala Gly Ala Tyr Asp  Ile Ile Ile Cys Asp  Glu Cys His 
    1310                 1315                 1320             


Ser Val  Asp Ala Thr Thr Ile  Leu Gly Ile Gly Thr  Val Leu Asp 
    1325                 1330                 1335             


Gln Ala  Glu Thr Ala Gly Val  Arg Leu Val Val Leu  Ala Thr Ala 
    1340                 1345                 1350             


Thr Pro  Pro Gly Thr Val Thr  Thr Pro His Ser Asn  Ile Glu Glu 
    1355                 1360                 1365             


Val Ala  Leu Gly His Glu Gly  Glu Ile Pro Phe Tyr  Gly Lys Ala 
    1370                 1375                 1380             


Ile Pro  Leu Ala Phe Ile Lys  Gly Gly Arg His Leu  Ile Phe Cys 
    1385                 1390                 1395             


His Ser  Lys Lys Lys Cys Asp  Glu Leu Ala Ala Ala  Leu Arg Gly 
    1400                 1405                 1410             


Met Gly  Val Asn Ala Val Ala  Tyr Tyr Arg Gly Leu  Asp Val Ser 
    1415                 1420                 1425             


Val Ile  Pro Thr Gln Gly Asp  Val Val Val Val Ala  Thr Asp Ala 
    1430                 1435                 1440             


Leu Met  Thr Gly Tyr Thr Gly  Asp Phe Asp Ser Val  Ile Asp Cys 
    1445                 1450                 1455             


Asn Val  Ala Val Ser Gln Ile  Val Asp Leu Ser Leu  Asp Pro Thr 
    1460                 1465                 1470             


Phe Thr  Ile Thr Thr Gln Ile  Val Pro Gln Asp Ala  Val Ser Arg 
    1475                 1480                 1485             


Ser Gln  Arg Arg Gly Arg Thr  Gly Arg Gly Arg Leu  Gly Val Tyr 
    1490                 1495                 1500             


Arg Tyr  Val Ser Ser Gly Glu  Arg Pro Ser Gly Met  Phe Asp Ser 
    1505                 1510                 1515             


Val Val  Leu Cys Glu Cys Tyr  Asp Ala Gly Ala Ala  Trp Tyr Glu 
    1520                 1525                 1530             


Leu Thr  Pro Ala Glu Thr Thr  Val Arg Leu Arg Ala  Tyr Phe Asn 
    1535                 1540                 1545             


Thr Pro  Gly Leu Pro Val Cys  Gln Asp His Leu Glu  Phe Trp Glu 
    1550                 1555                 1560             


Ala Val  Phe Thr Gly Leu Thr  His Ile Asp Ala His  Phe Leu Ser 
    1565                 1570                 1575             


Gln Thr  Lys Gln Gly Gly Glu  Asn Phe Ala Tyr Leu  Thr Ala Tyr 
    1580                 1585                 1590             


Gln Ala  Thr Val Cys Ala Arg  Ala Lys Ala Pro Pro  Pro Ser Trp 
    1595                 1600                 1605             


Asp Val  Met Trp Lys Cys Leu  Thr Arg Leu Lys Pro  Thr Leu Thr 
    1610                 1615                 1620             


Gly Pro  Thr Pro Leu Leu Tyr  Arg Leu Gly Ala Val  Thr Asn Glu 
    1625                 1630                 1635             


Val Thr  Leu Thr His Pro Val  Thr Lys Tyr Ile Ala  Thr Cys Met 
    1640                 1645                 1650             


Gln Ala  Asp Leu Glu Ile Met  Thr Ser Ser Trp Val  Leu Ala Gly 
    1655                 1660                 1665             


Gly Val  Leu Ala Ala Val Ala  Ser Tyr Cys Leu Ala  Thr Gly Cys 
    1670                 1675                 1680             


Ile Ser  Ile Ile Gly Arg Leu  His Leu Asn Asp Arg  Val Val Val 
    1685                 1690                 1695             


Ala Pro  Asp Lys Glu Ile Leu  Tyr Glu Ala Phe Asp  Glu Met Glu 
    1700                 1705                 1710             


Glu Cys  Ala Ser Lys Ala Ala  Leu Ile Glu Glu Gly  Gln Arg Met 
    1715                 1720                 1725             


Ala Glu  Met Leu Lys Ser Lys  Ile Gln Gly Leu Leu  Gln Gln Ala 
    1730                 1735                 1740             


Thr Arg  Gln Ala Gln Asp Ile  Gln Pro Ala Ile Gln  Ser Ser Trp 
    1745                 1750                 1755             


Pro Lys  Leu Glu Gln Phe Trp  Ala Lys His Met Trp  Asn Phe Ile 
    1760                 1765                 1770             


Ser Gly  Ile Gln Tyr Leu Ala  Gly Leu Ser Thr Leu  Pro Gly Asn 
    1775                 1780                 1785             


Pro Ala  Val Ala Ser Met Met  Ala Phe Ser Ala Ala  Leu Thr Ser 
    1790                 1795                 1800             


Pro Leu  Pro Thr Ser Thr Thr  Ile Leu Leu Asn Ile  Met Gly Gly 
    1805                 1810                 1815             


Trp Leu  Ala Ser Gln Ile Ala  Pro Pro Ala Gly Ala  Thr Gly Phe 
    1820                 1825                 1830             


Val Val  Ser Gly Leu Val Gly  Ala Ala Val Gly Ser  Ile Gly Leu 
    1835                 1840                 1845             


Gly Lys  Ile Leu Val Asp Val  Leu Ala Gly Tyr Gly  Ala Gly Ile 
    1850                 1855                 1860             


Ser Gly  Ala Leu Val Ala Phe  Lys Ile Met Ser Gly  Glu Lys Pro 
    1865                 1870                 1875             


Thr Val  Glu Asp Val Val Asn  Leu Leu Pro Ala Ile  Leu Ser Pro 
    1880                 1885                 1890             


Gly Ala  Leu Val Val Gly Val  Ile Cys Ala Ala Ile  Leu Arg Arg 
    1895                 1900                 1905             


His Val  Gly Gln Gly Glu Gly  Ala Val Gln Trp Met  Asn Arg Leu 
    1910                 1915                 1920             


Ile Ala  Phe Ala Ser Arg Gly  Asn His Val Ala Pro  Thr His Tyr 
    1925                 1930                 1935             


Val Val  Glu Ser Asp Ala Ser  Gln Arg Val Thr Gln  Val Leu Ser 
    1940                 1945                 1950             


Ser Leu  Thr Ile Thr Ser Leu  Leu Arg Arg Leu His  Ala Trp Val 
    1955                 1960                 1965             


Thr Glu  Asp Cys Pro Val Pro  Cys Ser Gly Ser Trp  Leu Gln Asp 
    1970                 1975                 1980             


Ile Trp  Asp Trp Val Cys Ser  Ile Leu Thr Asp Phe  Lys Asn Trp 
    1985                 1990                 1995             


Leu Ser  Ser Lys Leu Leu Pro  Lys Met Pro Gly Ile  Pro Phe Ile 
    2000                 2005                 2010             


Ser Cys  Gln Lys Gly Tyr Lys  Gly Val Trp Ala Gly  Thr Gly Val 
    2015                 2020                 2025             


Met Thr  Thr Arg Cys Pro Cys  Gly Ala Asn Ile Ser  Gly His Val 
    2030                 2035                 2040             


Arg Met  Gly Thr Met Lys Ile  Thr Gly Pro Lys Thr  Cys Leu Asn 
    2045                 2050                 2055             


Leu Trp  Gln Gly Thr Phe Pro  Ile Asn Cys Tyr Thr  Glu Gly Pro 
    2060                 2065                 2070             


Cys Val  Pro Lys Pro Pro Pro  Asn Tyr Lys Thr Ala  Ile Trp Arg 
    2075                 2080                 2085             


Val Ala  Ala Ser Glu Tyr Val  Glu Val Thr Gln His  Gly Ser Phe 
    2090                 2095                 2100             


Ser Tyr  Val Thr Gly Leu Thr  Ser Asp Asn Leu Lys  Val Pro Cys 
    2105                 2110                 2115             


Gln Val  Pro Ala Pro Glu Phe  Phe Ser Trp Val Asp  Gly Val Gln 
    2120                 2125                 2130             


Ile His  Arg Phe Ala Pro Val  Pro Gly Pro Phe Phe  Arg Asp Glu 
    2135                 2140                 2145             


Val Thr  Phe Thr Val Gly Leu  Asn Ser Phe Val Val  Gly Ser Gln 
    2150                 2155                 2160             


Leu Pro  Cys Asp Pro Glu Pro  Asp Thr Glu Val Leu  Ala Ser Met 
    2165                 2170                 2175             


Leu Thr  Asp Pro Ser His Ile  Thr Ala Glu Ala Ala  Ala Arg Arg 
    2180                 2185                 2190             


Leu Ala  Arg Gly Ser Pro Pro  Ser Gln Ala Ser Ser  Ser Ala Ser 
    2195                 2200                 2205             


Gln Leu  Ser Ala Pro Ser Leu  Lys Ala Thr Cys Thr  Thr His Lys 
    2210                 2215                 2220             


Thr Ala  Tyr Asp Cys Asp Met  Val Asp Ala Asn Leu  Phe Met Gly 
    2225                 2230                 2235             


Gly Asp  Val Thr Arg Ile Glu  Ser Asp Ser Lys Val  Ile Val Leu 
    2240                 2245                 2250             


Asp Ser  Leu Asp Ser Met Thr  Glu Val Val Asp Asp  Arg Glu Pro 
    2255                 2260                 2265             


Ser Val  Pro Ser Glu Tyr Leu  Ile Lys Arg Arg Lys  Phe Pro Pro 
    2270                 2275                 2280             


Ala Leu  Pro Pro Trp Ala Arg  Pro Asp Tyr Asn Pro  Val Leu Ile 
    2285                 2290                 2295             


Glu Thr  Trp Lys Arg Pro Gly  Tyr Glu Pro Pro Thr  Val Leu Gly 
    2300                 2305                 2310             


Cys Ala  Leu Pro Pro Thr Pro  Gln Thr Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Arg Arg  Arg Ala Lys Val Leu  Thr Gln Asp Asn Val  Glu Gly Ile 
    2330                 2335                 2340             


Leu Arg  Glu Met Ala Asp Lys  Val Leu Ser Pro Leu  Gln Asp Asn 
    2345                 2350                 2355             


Asn Asp  Ser Gly His Ser Thr  Gly Ala Asp Thr Gly  Gly Asp Ile 
    2360                 2365                 2370             


Val Gln  Gln Pro Ser Asp Glu  Thr Ala Ala Ser Glu  Ala Gly Ser 
    2375                 2380                 2385             


Leu Ser  Ser Met Pro Pro Leu  Glu Gly Glu Pro Gly  Asp Pro Asp 
    2390                 2395                 2400             


Leu Glu  Phe Glu Pro Val Gly  Ser Ala Pro Pro Ser  Glu Gly Glu 
    2405                 2410                 2415             


Cys Glu  Val Ile Asp Ser Asp  Ser Lys Ser Trp Ser  Thr Val Ser 
    2420                 2425                 2430             


Asp Gln  Glu Asp Ser Val Ile  Cys Cys Ser Met Ser  Tyr Ser Trp 
    2435                 2440                 2445             


Thr Gly  Ala Leu Ile Thr Pro  Cys Gly Pro Glu Glu  Glu Lys Leu 
    2450                 2455                 2460             


Pro Ile  Asn Pro Leu Ser Asn  Ser Leu Met Arg Phe  His Asn Lys 
    2465                 2470                 2475             


Val Tyr  Ser Thr Thr Ser Arg  Ser Ala Ser Leu Arg  Ala Lys Lys 
    2480                 2485                 2490             


Val Thr  Phe Asp Arg Val Gln  Val Leu Asp Ala His  Tyr Asp Ser 
    2495                 2500                 2505             


Val Leu  Gln Asp Val Lys Arg  Ala Ala Ser Lys Val  Ser Ala Arg 
    2510                 2515                 2520             


Leu Leu  Thr Val Glu Glu Ala  Cys Ala Leu Thr Pro  Pro His Ser 
    2525                 2530                 2535             


Ala Lys  Ser Arg Tyr Gly Phe  Gly Ala Lys Glu Val  Arg Ser Leu 
    2540                 2545                 2550             


Ser Arg  Arg Ala Val Asn His  Ile Arg Ser Val Trp  Glu Asp Leu 
    2555                 2560                 2565             


Leu Glu  Asp Gln His Thr Pro  Ile Asp Thr Thr Ile  Met Ala Lys 
    2570                 2575                 2580             


Asn Glu  Val Phe Cys Ile Asp  Pro Thr Lys Gly Gly  Lys Lys Pro 
    2585                 2590                 2595             


Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly Val Arg  Val Cys Glu 
    2600                 2605                 2610             


Lys Met  Ala Leu Tyr Asp Ile  Ala Gln Lys Leu Pro  Lys Ala Ile 
    2615                 2620                 2625             


Met Gly  Pro Ser Tyr Gly Phe  Gln Tyr Ser Pro Ala  Glu Arg Val 
    2630                 2635                 2640             


Asp Phe  Leu Leu Lys Ala Trp  Gly Ser Lys Lys Asp  Pro Met Gly 
    2645                 2650                 2655             


Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser Thr Val  Thr Glu Arg 
    2660                 2665                 2670             


Asp Ile  Arg Thr Glu Glu Ser  Ile Tyr Gln Ala Cys  Ser Leu Pro 
    2675                 2680                 2685             


Gln Glu  Ala Arg Thr Val Ile  His Ser Leu Thr Glu  Arg Leu Tyr 
    2690                 2695                 2700             


Val Gly  Gly Pro Met Thr Asn  Ser Lys Gly Gln Ser  Cys Gly Tyr 
    2705                 2710                 2715             


Arg Arg  Cys Arg Ala Ser Gly  Val Phe Thr Thr Ser  Met Gly Asn 
    2720                 2725                 2730             


Thr Met  Thr Cys Tyr Ile Lys  Ala Leu Ala Ala Cys  Lys Ala Ala 
    2735                 2740                 2745             


Gly Ile  Val Asp Pro Val Met  Leu Val Cys Gly Asp  Asp Leu Val 
    2750                 2755                 2760             


Val Ile  Ser Glu Ser Gln Gly  Asn Glu Glu Asp Glu  Arg Asn Leu 
    2765                 2770                 2775             


Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr Ser Ala  Pro Pro Gly 
    2780                 2785                 2790             


Asp Leu  Pro Arg Pro Glu Tyr  Asp Leu Glu Leu Ile  Thr Ser Cys 
    2795                 2800                 2805             


Ser Ser  Asn Val Ser Val Ala  Leu Asp Ser Arg Gly  Arg Arg Arg 
    2810                 2815                 2820             


Tyr Phe  Leu Thr Arg Asp Pro  Thr Thr Pro Ile Thr  Arg Ala Ala 
    2825                 2830                 2835             


Trp Glu  Thr Val Arg His Ser  Pro Val Asn Ser Trp  Leu Gly Asn 
    2840                 2845                 2850             


Ile Ile  Gln Tyr Ala Pro Thr  Ile Trp Val Arg Met  Val Ile Met 
    2855                 2860                 2865             


Thr His  Phe Phe Ser Ile Leu  Leu Ala Gln Asp Thr  Leu Asn Gln 
    2870                 2875                 2880             


Asn Leu  Asn Phe Glu Met Tyr  Gly Ala Val Tyr Ser  Val Ser Pro 
    2885                 2890                 2895             


Leu Asp  Leu Pro Ala Ile Ile  Glu Arg Leu His Gly  Leu Glu Ala 
    2900                 2905                 2910             


Phe Ser  Leu His Thr Tyr Ser  Pro Arg Glu Leu Ser  Arg Val Ala 
    2915                 2920                 2925             


Ala Thr  Leu Arg Lys Leu Gly  Ala Pro Pro Leu Arg  Ala Trp Lys 
    2930                 2935                 2940             


Ser Arg  Ala Arg Ala Val Arg  Ala Ser Leu Ile Ala  Gln Gly Ala 
    2945                 2950                 2955             


Arg Ala  Ala Ile Cys Gly Arg  Tyr Leu Phe Asn Trp  Ala Val Lys 
    2960                 2965                 2970             


Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Glu Ala Ser  Arg Leu Asp 
    2975                 2980                 2985             


Leu Ser  Gly Trp Phe Thr Val  Gly Ala Gly Gly Gly  Gly Ile Tyr 
    2990                 2995                 3000             


His Ser  Val Ser His Ala Arg  Pro Arg Leu Leu Leu  Leu Cys Leu 
    3005                 3010                 3015             


Leu Leu  Leu Ser Val Gly Val  Gly Ile Phe Leu Leu  Pro Ala Arg 
    3020                 3025                 3030             


<210>  133
<211>  9613
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid

<400>  133
gccagccccc tgatgggggc gacactccac catgaatcac tcccctgtga ggaactactg       60

tcttcacgca gaaagcgtct agccatggcg ttagtatgag tgtcgtgcag cctccaggac      120

cccccctccc gggagagcca tagtggtctg cggaaccggt gagtacaccg gaattgccag      180

gacgaccggg tcctttcttg gatcaacccg ctcaatgcct ggagatttgg gcgtgccccc      240

gcaagactgc tagccgagta gtgttgggtc gcgaaaggcc ttgtggtact gcctgatagg      300

gtgcttgcga gtgccccggg aggtctcgta gaccgtgcac catgagcacg aatcctaaac      360

ctcaaagaaa aaccaaacgt aacaccaacc gtcgcccaca ggacgtcaag ttcccgggtg      420

gcggtcagat cgttggtgga gtttacttgt tgccgcgcag gggccctaga ttgggtgtgc      480

gcgcgacgag gaagacttcc gagcggtcgc aacctcgagg tagacgtcag cctatcccca      540

aggcgcgtcg gcccgagggc aggacctggg ctcagcccgg gtacccttgg cccctctatg      600

gcaatgaggg ttgcgggtgg gcgggatggc tcctgtctcc ccgtggctct cggcctagct      660

ggggccccac ggacccccgg cgtaggtcgc gcaatttggg taaggtcatc gataccctta      720

cgtgcggctt cgccgacctc atggggtaca taccgctcgt cggcgcccct cttggaggcg      780

ctgccagggc cctggcgcat ggcgtccggg ttttggaaga cggcgtgaac tatgcaacag      840

ggaaccttcc tggttgctct ttctctattt tccttctggc cctgctctct tgtctgactg      900

gacccgcttc agcctaccaa gtgcgcaact ccacggggct ttaccatgtc accaatgatt      960

gccccaactc gagcattgtg ttcgaggcgg ctgatgccat cctgcacact ccggggtgtg     1020

tcccttgcgt acgcgagggt aacgcctcga ggtgttgggt ggcggtaacc cccacggtgg     1080

ccaccaggga tggcaaactc cccacaacgc agcttcgacg tcacatcgat ctgcttgtcg     1140

ggagcgccac cctctgctcg gccctttacg tgggggacct gtgcgggtct gtctttcttg     1200

ttggtcaact gttcaccttc tctcccaggc gccactggac gacgcaagat tgcaattgtt     1260

ctatctaccc cggccatatt tcaggtcacc gtatggcatg ggatatgatg atgaactggt     1320

cccctacggc ggcgttgttg gtagctcagc tgctccggat cccacaagcc atcctggaca     1380

tgatcgctgg tgctcactgg ggagtcctgg cgggcatggc gtatttctcc atggtgggga     1440

actgggcgaa ggttctggta gtgctgctgc tatttgccgg cgtcgacgcg gaaacctacg     1500

tcaccggggg aagtgccgcc cgtactacgg ctggacttgc tagtcttttc tcaccaggcg     1560

ccaagcagaa catccagctg gtcaacacca acggcagttg gcacatcaat agcacggcct     1620

tgaactgcaa tgacagcctc aacaccggct ggatagcagg acttttctat caccacaaat     1680

tcaactcttc gggctgttcc gagaggttag ccagctgccg accccttacc gattttgccc     1740

agggctgggg ccctatcagt cacgccgacg gaagtggccc cgaccaacgc ccctactgct     1800

ggcactaccc tccaaaacct tgtggtattg tgcccgcaaa gagcgtgtgt ggcccggtat     1860

attgtttcac tcccagtccc gtggtggtgg gaacgaccga caggtcgggc gcgcctacct     1920

acagctgggg tgcaaatgac acggacgtct tcgtccttaa caacaccagg ccaccgctgg     1980

gcaattggtt cggttgcacc tggatgaact caactggatt caccaaagtg tgcggagcgc     2040

ccccttgcgt catcggaggg gtgggcaaca acaccttgcg ctgccccact gattgtttcc     2100

gcaagcatcc ggaagccaca tactctcggt gcggctccgg tccctggatt acgcccaggt     2160

gcctggtcga ctacccgtat aggctttggc attatccttg taccatcaac tacaccgtgt     2220

ttaaagtcag gatgtacgtg ggaggggtcg agcacaggct ggaagctgcc tgcaactgga     2280

cgcggggcga ccgttgtaat ctggatgaca gggacaggtc cgagctcagc ccgctgctgc     2340

tgtccactac gcagtggcag gtcctcccgt gttccttcac gaccctgcca gccttgtcca     2400

ccggcctcat ccacctccac caaaacatcg tggacgtgca atacttgtac ggggtgggat     2460

caagcatcgc gtcctgggcc atcaagtggg aatacgtcgt tctcttgttc cttctgcttg     2520

cagacgcgcg cgtctgctcc tgcttgtgga tgatgttact catatcccaa gtggaggcgg     2580

ctttggagaa cctcgtagta ctcaatgcag catccctggc cgggacacac ggtcttgtat     2640

ccttcctcgt gttcttctgc tttgcatggt atctgaaggg taagtgggtg cccggagcgg     2700

tctacgccct ctacgggatg tggcctctcc tcttgctcct gttagcgttg ccccagcggg     2760

catacgcact ggacacggag gtggccgcgt cgtgtggcgg cgttgttctt gtcgggttaa     2820

tggcgctgac tctgtcacca tattacaagc gctatatcag ctggtgcttg tggtggcttc     2880

agtatttcct gaccagaata gaagcgcaac tgcacgtgtg gattccccct ctcaacgtcc     2940

ggggggggcg cgatgccgtc atcttactca tgtgtgttgt gcacccggct ctggtatttg     3000

acatcaccaa gctactgctg gctgccttcg ggcccctttg gattcttcaa gccagtttgc     3060

ttaaggtacc ctacttcgtg cgcgttcaag gccttctccg gatctgcgcg ctagcgcgga     3120

agatggctgg aggccattac gtgcaaatgg ccatcatcaa gttaggggcg cttactggca     3180

cttatgttta caaccatctc accccccttc gggactgggc gcacaacggc ctgcgagatc     3240

tggccgtggc tgtggagcca gtcgtcttct cccgaatgga gaccaagctt atcacctggg     3300

gggcagacac cgccgcgtgc ggtgacatca tcaacggctt gcccgtctcc gcccggaggg     3360

gccgggagat actgctcggg ccagccgatg gaatggtctc caaggggtgg agattgctgg     3420

cgcccatcac ggcgtacgcc cagcaaacga ggggcctcct agggtgtata atcaccagtc     3480

tgaccggccg ggacaaaaac caagtggagg gtgagatcca gattgtgtca actgctgccc     3540

aaaccttcct ggcaacgtgc atcaacgggg tttgctggac cgtctaccac ggggccggaa     3600

cgaggaccat cgcatcaccc aagggtccgg ttatccaaat gtataccaat gtggacaaag     3660

accttgtggg ctggcccgct cctcaaggtg cccgctcact gacaccctgt acctgcggct     3720

cctcggacct ttacctggtc acgaggcacg ccgatgtcat tcccgtgcgc cggcggggtg     3780

atagcagggg cagcctgctt tcgccccggc ccatttccta cttgaaaggc tcctcggggg     3840

gtccgctgct gtgccccgcg ggacacgccg taggcttatt cagggccgcg gtgtgcaccc     3900

gtggagtggc taaggcggtg gacttcatcc ctgtggagaa cctagagaca accatgaggt     3960

ccccggtgtt cacggacaac tcctctccac cagcagtgcc ccagagcttc caggtggccc     4020

acctgcatgc tcccaccggc agcggcaaaa gcaccaaggt cccggctgca tacgcagctc     4080

agggctataa ggtgctagtg ctcaacccct ctgtcgctgc aacactgggc tttggtgctt     4140

acatgtccaa ggcccatggg gtcgatccta atatcaggac cggggtgaga acaattacca     4200

ctggcagccc catcacgtac tccacctacg gcaagttcct tgccgacggc gggtgttcag     4260

ggggtgctta tgacataata atttgtgacg agtgccactc cacggatgcc acatccatct     4320

tgggcatcgg caccgttctt gaccaagcag agaccgcggg ggcgagactg gttgtgctcg     4380

ccaccgctac ccctccgggc tccatcaccg tgccccatcc taacatcgag gaggttgctc     4440

tgtccactac cggagagatc cctttttacg gcaaggctat ccccctcgag gcgatcaagg     4500

gggggagaca tctcatcttc tgtcactcaa agaagaagtg cgacgagctc gccgcaaagc     4560

tggtcgcatt gggcatcaat gccgtggcct actaccgcgg tcttgacgtg tctgtcatcc     4620

caaccagcgg cgatgttgtc gtcgtggcga ccgatgctct tatgactggc tataccggcg     4680

actttgactc ggtgatagac tgcaacacgt gtgtcaccca gacagtcgac ttcagccttg     4740

accctacctt caccattgag acgaccacgc tcccccagga cgctgtctcc cgcacacaac     4800

gccggggcag gactggcagg gggaagccag gcatctacag attcgtggca ctgggggagc     4860

gcccctccgg catgttcgac tcgtccgttc tctgtgagtg ctatgacgcg ggctgtgctt     4920

ggtatgagct cacgcccgcc gagactacag ttagactacg agcgtacatg aacaccccgg     4980

ggctccctgt gtgccaggac catcttgaat tttgggaggg cgtctttaca ggcctcaccc     5040

atatagatgc ccatttccta tctcagacaa agcagagcgg ggaaaacttt ccttacctgg     5100

tagcatacca agcaaccgtg tgcgctaggg ctcaagcccc tcccccatcg tgggaccaga     5160

tgtggaagtg tttgactcgc ctcaagccca ccctccatgg gccaacaccc ttgctataca     5220

gactgggcgc tgttcagaat gaagtcaccc tgacgcaccc aatcaccaaa tacatcatga     5280

catgcatgtc ggccgacctg gaggtcgtca cgagcacctg ggtgctcgtc ggcggcgtcc     5340

tggccgcttt ggccgcgtat tgcctgtcaa caggctgcgt ggtcatagtg ggcaggattg     5400

tcctgtctgg gaagccggca attatacctg acagggaagt tctctaccgg gagttcgatg     5460

agatggaaga gtgctctcag cacttaccgt acatcgagca agggatgatg ctcgccgagc     5520

agttcaagca gaaggccctc ggcctcctgc agaccgcgtc ccgtcaggca gaggttgtcg     5580

cccctgctgt ccagaccaac tggcaaaaac tcgaggcctt ctgggcgaag catatgtgga     5640

acttcatcag tgggatacaa tacttggcgg gcttgtcaac gttgcctggt aaccccgcca     5700

ttgcttcatt gatggctttt acagctgctg tcaccagccc actaaccact agccaaaccc     5760

tcctcttcaa catactgggg gggtgggtgg ctgcccagct tgccgccccc ggtgccgcca     5820

ccgcctttgt gggcgctggc ttagccggcg ccgcaatcgg cagtgttgga ctggggaagg     5880

tcctcgtgga cattctagca gggtatggcg cgggcgtggc gggagctctt gtagcattca     5940

agatcatgag cggtgaggtc ccctccacgg aggacctagt caacctgctg cccgccatcc     6000

tctcgcctgg agcccttgta gtcggtgtgg tctgcgcagc aatactgcgc cggcacgtcg     6060

gcccgggcga gggggcagtg caatggatga accggctaat cgccttcgcc tcccggggga     6120

accatgtttc ccccacgcac tatgtgccgg agagcgatgc agctgcccgc gtcactacca     6180

tactcagcag cctcactgta acccagctcc tgaggcgact gcaccagtgg ataagctcgg     6240

agtgtaccac tccatgctcc ggttcctggc tgagggacat ctgggactgg atatgcgagg     6300

tgctgagcga ctttaagacc tggctgaaag ccaagctcat gccgcaactg cctgggattc     6360

cctttgtgtc ctgccagcgt gggtataagg gggtctggcg aggggacggc atcatgcaca     6420

ctcgctgcca ctgtggagct gagataactg gacatgtcaa aaacgggacg atgaggatcg     6480

ttggtcctaa gacttgcagg aacatgtgga gtgggacttt ccccattaac gcctacacca     6540

cgggcccctg tactcccctt cctgcgccga actatacgtt cgcgctgtgg agggtgtctg     6600

cagaggaata cgtggagata aggcaggtgg gggacttcca ctacgtgacg ggtatgacta     6660

ctgacaacct taaatgcccg tgccaggtcc catcgcccga atttttcaca gaattggacg     6720

gggtgcgcct acataggttt gcgccccctt gcaagcccct gctgcgggag gaggtgtcat     6780

tcagagtggg actccacgag tacccggtgg ggtcgcaatt accttgcgag cccgaaccgg     6840

acgtggccgt gttgacgtcc atgctcactg atccctccca tataacagca gaggcggccg     6900

ggagaaggtt ggcgagggga tcacccccct ctatggccag ctcctcggct agccaactgt     6960

ccgctccatc tctcagggca acttgcacta ccaaccatga ctcccctgat gctgagctca     7020

tagaggccaa cctcctatgg aggcaggaga tgggcggcaa catcaccagg gttgagtcag     7080

agaacaaagt ggtgattctg gactccttcg atccgcttgt ggcagaggag gatgagcggg     7140

aggtctccgt gcccgcagag atactgcgga agtctcggaa attcacccca gccctaccca     7200

tttgggcgcg gccggactat aaccccccgc tggtggagcc gtggaaaaag cctgactacg     7260

aaccacctgt ggtccatggc tgcccgcttc cacctccaca gtcccctcct gtgcctccac     7320

ctcggaagaa gcggacggtg atcctcaccg aatcaaccct acctactgcc ttggccgagc     7380

ttgccaccaa aagttttggc agctcctcaa cttccggcat tacgggcgac gacacgacaa     7440

catcccctga gcccgcctcc tctagctgcc ctcccgactc cgacgctgag tcctattctt     7500

ccatgccccc tctggagggg gagcctgggg atccggatct cagcgacggg tcatggtcga     7560

cggtcagtag tgaggccgac aaggaggatg tcgtgtgctg ctccatgtca tactcctgga     7620

ccggggctct aataactccc tgtagccccg aagaggaaaa gttgccaatc aaccctttga     7680

gtaactcgct gttgcgatac cataacaagg tgtactgtac aacatcaaag agcgcctcac     7740

agagggctaa aaaggtaact tttgacagga cgcaagtgct cgacgcccat tatgactcag     7800

tcttaaagga catcaagcta gcggcttcca aggtcagcgc aaggctcctc accttggagg     7860

aggcgtgcca gttgactcca ccccattctg caagatccaa gtatggattc ggggccaagg     7920

aggtccgcag cttgtccggg agggccgtta accacatcaa gtccgtgtgg aaggacctcc     7980

tggaagaccc acaaacacca attcccacaa ccatcatggc caaaaatgag gtgttctgcg     8040

tggaccccgc caaggggggt aagaaaccag ctcgcctcat cgtttaccct gacctcggcg     8100

tccgggtctg cgagaaaatg gccctctatg acattacaca aaagcttcct caggcggtaa     8160

tgggagcttc ctatggcttc cagtactccc ctgcccaacg ggtggagtat ctcttgaaag     8220

catgggcgga aaagaaggac cccatgggtt tttcgtatga tacccgatgc ttcgactcaa     8280

ccgtcactga gagagacatc aggaccgagg agtccatata ccaggcctgc tccctgcccg     8340

aggaggcccg cactgccata cactcgctga ctgagagact ttacgtagga gggcccatgt     8400

tcaacagcaa gggtcaaacc tgcggttaca gacgttgccg cgccagcggg gtgctaacca     8460

ctagcatggg taacaccatc acatgctatg tgaaagccct agcggcctgc aaggctgcgg     8520

ggatagttgc gcccacaatg ctggtatgcg gcgatgacct agtagtcatc tcagaaagcc     8580

aggggactga ggaggacgag cggaacctga gagccttcac ggaggccatg accaggtact     8640

ctgcccctcc tggtgatccc cccagaccgg aatatgacct ggagctaata acatcctgtt     8700

cctcaaatgt gtctgtggcg ttgggcccgc ggggccgccg cagatactac ctgaccagag     8760

acccaaccac tccactcgcc cgggctgcct gggaaacagt tagacactcc cctatcaatt     8820

catggctggg aaacatcatc cagtatgctc caaccatatg ggttcgcatg gtcctaatga     8880

cacacttctt ctccattctc atggtccaag acaccctgga ccagaacctc aactttgaga     8940

tgtatggatc agtatactcc gtgaatcctt tggaccttcc agccataatt gagaggttac     9000

acgggcttga cgccttttct atgcacacat actctcacca cgaactgacg cgggtggctt     9060

cagccctcag aaaacttggg gcgccacccc tcagggtgtg gaagagtcgg gctcgcgcag     9120

tcagggcgtc cctcatctcc cgtggaggga aagcggccgt ttgcggccga tatctcttca     9180

attgggcggt gaagaccaag ctcaaactca ctccattgcc ggaggcgcgc ctactggact     9240

tatccagttg gttcaccgtc ggcgccggcg ggggcgacat ttttcacagc gtgtcgcgcg     9300

cccgaccccg ctcattactc ttcggcctac tcctactttt cgtaggggta ggcctcttcc     9360

tactccccgc tcggtagagc ggcacacact aggtacactc catagctaac tgttcctttt     9420

tttttttttt tttttttttt tttttttttt tttttttttc tttttttttt ttttccctct     9480

ttcttccctt ctcatcttat tctactttct ttcttggtgg ctccatctta gccctagtca     9540

cggctagctg tgaaaggtcc gtgagccgca tgactgcaga gagtgccgta actggtctct     9600

ctgcagatca tgt                                                        9613


<210>  134
<211>  9613
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid

<400>  134
gccagccccc tgatgggggc gacactccac catgaatcac tcccctgtga ggaactactg       60

tcttcacgca gaaagcgtct agccatggcg ttagtatgag tgtcgtgcag cctccaggac      120

cccccctccc gggagagcca tagtggtctg cggaaccggt gagtacaccg gaattgccag      180

gacgaccggg tcctttcttg gatcaacccg ctcaatgcct ggagatttgg gcgtgccccc      240

gcaagactgc tagccgagta gtgttgggtc gcgaaaggcc ttgtggtact gcctgatagg      300

gtgcttgcga gtgccccggg aggtctcgta gaccgtgcac catgagcacg aatcctaaac      360

ctcaaagaaa aaccaaacgt aacaccaacc gtcgcccaca ggacgtcaag ttcccgggtg      420

gcggtcagat cgttggtgga gtttacttgt tgccgcgcag gggccctaga ttgggtgtgc      480

gcgcgacgag gaagacttcc gagcggtcgc aacctcgagg tagacgtcag cctatcccca      540

aggcgcgtcg gcccgagggc aggacctggg ctcagcccgg gtacccttgg cccctctatg      600

gcaatgaggg ttgcgggtgg gcgggatggc tcctgtctcc ccgtggctct cggcctagct      660

ggggccccac ggacccccgg cgtaggtcgc gcaatttggg taaggtcatc gataccctta      720

cgtgcggctt cgccgacctc atggggtaca taccgctcgt cggcgcccct cttggaggcg      780

ctgccagggc cctggcgcat ggcgtccggg ttttggaaga cggcgtgaac tatgcaacag      840

ggaaccttcc tggttgctct ttctctattt tccttctggc cctgctctct tgtctgactg      900

gacccgcttc agcctaccaa gtgcgcaact ccacggggct ttaccatgtc accaatgatt      960

gccccaactc gagcattgtg ttcgaggcgg ctgatgccat cctgcacact ccggggtgtg     1020

tcccttgcgt acgcgagggt aacgcctcga ggtgttgggt ggcggtaacc cccacggtgg     1080

ccaccaggga tggcaaactc cccacaacgc agcttcgacg tcacatcgat ctgcttgtcg     1140

ggagcgccac cctctgctcg gccctttacg tgggggacct gtgcgggtct gtctttcttg     1200

ttggtcaact gttcaccttc tctcccaggc gccactggac gacgcaagat tgcaattgtt     1260

ctatctaccc cggccatatt tcaggtcacc gtatggcatg ggatatgatg atgaactggt     1320

cccctacggc ggcgttgttg gtagctcagc tgctccggat cccacaagcc atcctggaca     1380

tgatcgctgg tgctcactgg ggagtcctgg cgggcatggc gtatttctcc atggtgggga     1440

actgggcgaa ggttctggta gtgctgctgc tatttgccgg cgtcgacgcg gaaacctacg     1500

tcaccggggg aagtgccgcc cgtactacgg ctggacttgc tagtcttttc tcaccaggcg     1560

ccaagcagaa catccagctg gtcaacacca acggcagttg gcacatcaat agcacggcct     1620

tgaactgcaa tgacagcctc aacaccggct ggatagcagg acttttctat caccacaaat     1680

tcaactcttc gggctgttcc gagaggttag ccagctgccg accccttacc gattttgccc     1740

agggctgggg ccctatcagt cacgccgacg gaagtggccc cgaccaacgc ccctactgct     1800

ggcactaccc tccaaaacct tgtggtattg tgcccgcaaa gagcgtgtgt ggcccggtat     1860

attgtttcac tcccagtccc gtggtggtgg gaacgaccga caggtcgggc gcgcctacct     1920

acagctgggg tgcaaatgac acggacgtct tcgtccttaa caacaccagg ccaccgctgg     1980

gcaattggtt cggttgcacc tggatgaact caactggatt caccaaagtg tgcggagcgc     2040

ccccttgcgt catcggaggg gtgggcaaca acaccttgcg ctgccccact gattgtttcc     2100

gcaagcatcc ggaagccaca tactctcggt gcggctccgg tccctggatt acgcccaggt     2160

gcctggtcga ctacccgtat aggctttggc attatccttg taccatcaac tacaccgtgt     2220

ttaaagtcag gatgtacgtg ggaggggtcg agcacaggct ggaagctgcc tgcaactgga     2280

cgcggggcga ccgttgtaat ctggatgaca gggacaggtc cgagctcagc ccgctgctgc     2340

tgtccactac gcagtggcag gtcctcccgt gttccttcac gaccctgcca gccttgtcca     2400

ccggcctcat ccacctccac caaaacatcg tggacgtgca atacttgtac ggggtgggat     2460

caagcatcgc gtcctgggcc atcaagtggg aatacgtcgt tctcttgttc cttctgcttg     2520

cagacgcgcg cgtctgctcc tgcttgtgga tgatgttact catatcccaa gtggaggcgg     2580

ctttggagaa cctcgtagta ctcaatgcag catccctggc cgggacacac ggtcttgtat     2640

ccttcctcgt gttcttctgc tttgcatggt atctgaaggg taagtgggtg cccggagcgg     2700

tctacgccct ctacgggatg tggcctctcc tcttgctcct gttagcgttg ccccagcggg     2760

catacgcact ggacacggag gtggccgcgt cgtgtggcgg cgttgttctt gtcgggttaa     2820

tggcgctgac tctgtcacca tattacaagc gctatatcag ctggtgcttg tggtggcttc     2880

agtatttcct gaccagaata gaagcgcaac tgcacgtgtg gattccccct ctcaacgtcc     2940

ggggggggcg cgatgccgtc atcttactca tgtgtgttgt gcacccggct ctggtatttg     3000

acatcaccaa gctactgctg gctgccttcg ggcccctttg gattcttcaa gccagtttgc     3060

ttaaggtacc ctacttcgtg cgcgttcaag gccttctccg gatctgcgcg ctagcgcgga     3120

agatggctgg aggccattac gtgcaaatgg ccatcatcaa gttaggggcg cttactggca     3180

cttatgttta caaccatctc accccccttc gggactgggc gcacaacggc ctgcgagatc     3240

tggccgtggc tgtggagcca gtcgtcttct cccgaatgga gaccaagctt atcacctggg     3300

gggcagacac cgccgcgtgc ggtgacatca tcaacggctt gcccgtctcc gcccggaggg     3360

gccgggagat actgctcggg ccagccgatg gaatggtctc caaggggtgg agattgctgg     3420

cgcccatcac ggcgtacgcc cagcaaacga ggggcctcct agggtgtata atcaccagtc     3480

tgaccggccg ggacaaaaac caagtggagg gtgagatcca gattgtgtca actgctgccc     3540

aaaccttcct ggcaacgtgc atcaacgggg tttgctggac cgtctaccac ggggccggaa     3600

cgaggaccat cgcatcaccc aagggtccgg ttatccaaat gtataccaat gtggacaaag     3660

accttgtggg ctggcccgct cctcaaggtg cccgctcact gacaccctgt acctgcggct     3720

cctcggacct ttacctggtc acgaggcacg ccgatgtcat tcccgtgcgc cggcggggtg     3780

atagcagggg cagcctgctt tcgccccggc ccatttccta cttgaaaggc tcctcggggg     3840

gtccgctgct gtgccccgcg ggacacgccg taggcttatt cagggccgcg gtgtgcaccc     3900

gtggagtggc taaggcggtg gacttcatcc ctgtggagaa cctagagaca accatgaggt     3960

ccccggtgtt cacggacaac tcctctccac cagcagtgcc ccagagcttc caggtggccc     4020

acctgcatgc tcccaccggc agcggcaaaa gcaccaaggt cccggctgca tacgcagctc     4080

agggctataa ggtgctagtg ctcaacccct ctgtcgctgc aacactgggc tttggtgctt     4140

acatgtccaa ggcccatggg gtcgatccta atatcaggac cggggtgaga acaattacca     4200

ctggcagccc catcacgtac tccacctacg gcaagttcct tgccgacggc gggtgttcag     4260

ggggtgctta tgacataata atttgtgacg agtgccactc cacggatgcc acatccatct     4320

tgggcatcgg caccgttctt gaccaagcag agaccgcggg ggcgagactg gttgtgctcg     4380

ccaccgctac ccctccgggc tccatcaccg tgccccatcc taacatcgag gaggttgctc     4440

tgtccactac cggagagatc cctttttacg gcaaggctat ccccctcgag gcgatcaagg     4500

gggggagaca tctcatcttc tgtcactcaa agaagaagtg cgacgagctc gccgcaaagc     4560

tggtcgcatt gggcatcaat gccgtggcct actaccgcgg tcttgacgtg tctgtcatcc     4620

caaccagcgg cgatgttgtc gtcgtggcga ccgatgctct tatgactggc tataccggcg     4680

actttgactc ggtgatagac tgcaacacgt gtgtcaccca gacagtcgac ctcagccttg     4740

accctacctt caccattgag acgaccacgc tcccccagga cgctgtctcc cgcacacaac     4800

gccggggcag gactggcagg gggaagccag gcatctacag attcgtggca ctgggggagc     4860

gcccctccgg catgttcgac tcgtccgttc tctgtgagtg ctatgacgcg ggctgtgctt     4920

ggtatgagct cacgcccgcc gagactacag ttagactacg agcgtacatg aacaccccgg     4980

ggctccctgt gtgccaggac catcttgaat tttgggaggg cgtctttaca ggcctcaccc     5040

atatagatgc ccatttccta tctcagacaa agcagagcgg ggaaaacttt ccttacctgg     5100

tagcatacca agcaaccgtg tgcgctaggg ctcaagcccc tcccccatcg tgggaccaga     5160

tgtggaagtg tttgactcgc ctcaagccca ccctccatgg gccaacaccc ttgctataca     5220

gactgggcgc tgttcagaat gaagtcaccc tgacgcaccc aatcaccaaa tacatcatga     5280

catgcatgtc ggccgacctg gaggtcgtca cgagcacctg ggtgctcgtc ggcggcgtcc     5340

tggccgcttt ggcctcgtat tgcctgtcaa caggctgcgt ggtcatagtg ggcaggattg     5400

tcctgtctgg gaagccggca attatacctg acagggaagt tctctaccgg gagttcgatg     5460

agatggaaga gtgctctcag cacttaccgt acatcgagca agggatgatg ctcgccgagc     5520

agttcaagca gaaggccctc ggcctcctgc agaccgcgtc ccgtcaggca gaggttgtcg     5580

cccctgctgt ccagaccaac tggcaaaaac tcgaggcctt ctgggcgaag catatgtgga     5640

acttcatcag tgggatacaa tacttggcgg gcttgtcaac gttgcctggt aaccccgcca     5700

ttgcttcatt gatggctttt acagctgctg tcaccagccc actaaccact agccaaaccc     5760

tcctcttcaa catactgggg gggtgggtgg ctgcccagct tgccgccccc ggtgccgcca     5820

ccgcctttgt gggcgctggc ttagccggcg ccgcaatcgg cagtgttgga ctggggaagg     5880

tcctcgtgga cattctagca gggtatggcg cgggcgtggc gggagctctt gtagcattca     5940

agatcatgag cggtgaggtc ccctccacgg aggacctagt caacctgctg cccgccatcc     6000

tctcgcctgg agcccttgta gtcggtgtgg tctgcgcagc aatactgcgc cggcacgtcg     6060

gcccgggcga gggggcagtg caatggatga accggctaat cgccttcgcc tcccggggga     6120

accatgtttc ccccacgcac tatgtgccgg agagcgatgc agctgcccgc gtcactacca     6180

tactcagcag cctcactgta acccagctcc tgaggcgact gcaccagtgg ataagctcgg     6240

agtgtaccac tccatgctcc ggttcctggc tgagggacat ctgggactgg atatgcgagg     6300

tgctgagcga ctttaagacc tggctgaaag ccaagctcat gccgcaactg cctgggattc     6360

cctttgtgtc ctgccagcgt gggtataagg gggtctggcg aggggacggc atcatgcaca     6420

ctcgctgcca ctgtggagct gagataactg gacatgtcaa aaacgggacg atgaggatcg     6480

ttggtcctaa gacttgcagg aacatgtgga gtgggacttt ccccattaac gcctacacca     6540

cgggcccctg tactcccctt cctgcgccga actatacgtt cgcgctgtgg agggtgtctg     6600

cagaggaata cgtggagata aggcaggtgg gggacttcca ctacgtgacg ggtatgacta     6660

ctgacaacct taaatgcccg tgccaggtcc catcgcccga atttttcaca gaattggacg     6720

gggtgcgcct acataggttt gcgccccctt gcaagcccct gctgcgggag gaggtgtcat     6780

tcagagtggg actccacgag tacccggtgg ggtcgcaatt accttgcgag cccgaaccgg     6840

acgtggccgt gttgacgtcc atgctcactg atccctccca tataacagca gaggcggccg     6900

ggagaaggtt ggcgagggga tcacccccct ctatggccag ctcctcggct agccaactgt     6960

ccgctccatc tctcagggca acttgcacta ccaaccatga ctcccctgat gctgagctca     7020

tagaggccaa cctcctatgg aggcaggaga tgggcggcaa catcaccagg gttgagtcag     7080

agaacaaagt ggtgattctg gactccttcg atccgcttgt ggcagaggag gatgagcggg     7140

aggtctccgt gcccgcagag atactgcgga agtctcggaa attcacccca gccctaccca     7200

tttgggcgcg gccggactat aaccccccgc tggtggagcc gtggaaaaag cctgactacg     7260

aaccacctgt ggtccatggc tgcccgcttc cacctccaca gtcccctcct gtgcctccac     7320

ctcggaagaa gcggacggtg atcctcaccg aatcaaccct acctactgcc ttggccgagc     7380

ttgccaccaa aagttttggc agctcctcaa cttccggcat tacgggcgac gacacgacaa     7440

catcccctga gcccgcctcc tctagctgcc ctcccgactc cgacgctgag tcctattctt     7500

ccatgccccc tctggagggg gagcctgggg atccggatct cagcgacggg tcatggtcga     7560

cggtcagtag tgaggccgac aaggaggatg tcgtgtgctg ctccatgtca tactcctgga     7620

ccggggctct aataactccc tgtagccccg aagaggaaaa gttgccaatc aaccctttga     7680

gtaactcgct gttgcgatac cataacaagg tgtactgtac aacatcaaag agcgcctcac     7740

agagggctaa aaaggtaact tttgacagga cgcaagtgct cgacgcccat tatgactcag     7800

tcttaaagga catcaagcta gcggcttcca aggtcagcgc aaggctcctc accttggagg     7860

aggcgtgcca gttgactcca ccccattctg caagatccaa gtatggattc ggggccaagg     7920

aggtccgcag cttgtccggg agggccgtta accacatcaa gtccgtgtgg aaggacctcc     7980

tggaagaccc acaaacacca attcccacaa ccatcatggc caaaaatgag gtgttctgcg     8040

tggaccccgc caaggggggt aagaaaccag ctcgcctcat cgtttaccct gacctcggcg     8100

tccgggtctg cgagaaaatg gccctctatg acattacaca aaagcttcct caggcggtaa     8160

tgggagcttc ctatggcttc cagtactccc ctgcccaacg ggtggagtat ctcttgaaag     8220

catgggcgga aaagaaggac cccatgggtt tttcgtatga tacccgatgc ttcgactcaa     8280

ccgtcactga gagagacatc aggaccgagg agtccatata ccaggcctgc tccctgcccg     8340

aggaggcccg cactgccata cactcgctga ctgagagact ttacgtagga gggcccatgt     8400

tcaacagcaa gggtcaaacc tgcggttaca gacgttgccg cgccagcggg gtgctaacca     8460

ctagcatggg taacaccatc acatgctatg tgaaagccct agcggcctgc aaggctgcgg     8520

ggatagttgc gcccacaatg ctggtatgcg gcgatgacct agtagtcatc tcagaaagcc     8580

aggggactga ggaggacgag cggaacctga gagccttcac ggaggccatg accaggtact     8640

ctgcccctcc tggtgatccc cccagaccgg aatatgacct ggagctaata acatcctgtt     8700

cctcaaatgt gtctgtggcg ttgggcccgc ggggccgccg cagatactac ctgaccagag     8760

acccaaccac tccactcgcc cgggctgcct gggaaacagt tagacactcc cctatcaatt     8820

catggctggg aaacatcatc cagtatgctc caaccatatg ggttcgcatg gtcctaatga     8880

cacacttctt ctccattctc atggtccaag acaccctgga ccagaacctc aactttgaga     8940

tgtatggatc agtatactcc gtgaatcctt tggaccttcc agccataatt gagaggttac     9000

acgggcttga cgccttttct atgcacacat actctcacca cgaactgacg cgggtggctt     9060

cagccctcag aaaacttggg gcgccacccc tcagggtgtg gaagagtcgg gctcgcgcag     9120

tcagggcgtc cctcatctcc cgtggaggga aagcggccgt ttgcggccga tatctcttca     9180

attgggcggt gaagaccaag ctcaaactca ctccattgcc ggaggcgcgc ctactggact     9240

tatccagttg gttcaccgtc ggcgccggcg ggggcggcat ttttcacagc gtgtcgcgcg     9300

cccgaccccg ctcattactc ttcggcctac tcctactttt cgtaggggta ggcctcttcc     9360

tactccccgc tcggtagagc ggcacacact aggtacactc catagctaac tgttcctttt     9420

tttttttttt tttttttttt tttttttttt tttttttttc tttttttttt ttttccctct     9480

ttcttccctt ctcatcttat tctactttct ttcttggtgg ctccatctta gccctagtca     9540

cggctagctg tgaaaggtcc gtgagccgca tgactgcaga gagtgccgta actggtctct     9600

ctgcagatca tgt                                                        9613


<210>  135
<211>  9613
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid

<400>  135
gccagccccc tgatgggggc gacactccac catgaatcac tcccctgtga ggaactactg       60

tcttcacgca gaaagcgtct agccatggcg ttagtatgag tgtcgtgcag cctccaggac      120

cccccctccc gggagagcca tagtggtctg cggaaccggt gagtacaccg gaattgccag      180

gacgaccggg tcctttcttg gatcaacccg ctcaatgcct ggagatttgg gcgtgccccc      240

gcaagactgc tagccgagta gtgttgggtc gcgaaaggcc ttgtggtact gcctgatagg      300

gtgcttgcga gtgccccggg aggtctcgta gaccgtgcac catgagcacg aatcctaaac      360

ctcaaagaaa aaccaaacgt aacaccaacc gtcgcccaca ggacgtcaag ttcccgggtg      420

gcggtcagat cgttggtgga gtttacttgt tgccgcgcag gggccctaga ttgggtgtgc      480

gcgcgacgag gaagacttcc gagcggtcgc aacctcgagg tagacgtcag cctatcccca      540

aggcgcgtcg gcccgagggc aggacctggg ctcagcccgg gtacccttgg cccctctatg      600

gcaatgaggg ttgcgggtgg gcgggatggc tcctgtctcc ccgtggctct cggcctagct      660

ggggccccac ggacccccgg cgtaggtcgc gcaatttggg taaggtcatc gataccctta      720

cgtgcggctt cgccgacctc atggggtaca taccgctcgt cggcgcccct cttggaggcg      780

ctgccagggc cctggcgcat ggcgtccggg ttttggaaga cggcgtgaac tatgcaacag      840

ggaaccttcc tggttgctct ttctctattt tccttctggc cctgctctct tgtctgactg      900

gacccgcttc agcctaccaa gtgcgcaact ccacggggct ttaccatgtc accaatgatt      960

gccccaactc gagcattgtg ttcgaggcgg ctgatgccat cctgcacact ccggggtgtg     1020

tcccttgcgt acgcgagggt aacgcctcga ggtgttgggt ggcggtaacc cccacggtgg     1080

ccaccaggga tggcaaactc cccacaacgc agcttcgacg tcacatcgat ctgcttgtcg     1140

ggagcgccac cctctgctcg gccctttacg tgggggacct gtgcgggtct gtctttcttg     1200

ttggtcaact gttcaccttc tctcccaggc gccactggac gacgcaagat tgcaattgtt     1260

ctatctaccc cggccatatt tcaggtcacc gtatggcatg ggatatgatg atgaactggt     1320

cccctacggc ggcgttgttg gtagctcagc tgctccggat cccacaagcc atcctggaca     1380

tgatcgctgg tgctcactgg ggagtcctgg cgggcatggc gtatttctcc atggtgggga     1440

actgggcgaa ggttctggta gtgctgctgc tatttgccgg cgtcgacgcg gaaacctacg     1500

tcaccggggg aagtgccgcc cgtactacgg ctggacttgc tagtcttttc tcaccaggcg     1560

ccaagcagaa catccagctg gtcaacacca acggcagttg gcacatcaat agcacggcct     1620

tgaactgcaa tgacagcctc aacaccggct ggatagcagg acttttctat caccacaaat     1680

tcaactcttc gggctgttcc gagaggttag ccagctgccg accccttacc gattttgccc     1740

agggctgggg ccctatcagt cacgccgacg gaagtggccc cgaccaacgc ccctactgct     1800

ggcactaccc tccaaaacct tgtggtattg tgcccgcaaa gagcgtgtgt ggcccggtat     1860

attgtttcac tcccagtccc gtggtggtgg gaacgaccga caggtcgggc gcgcctacct     1920

acagctgggg tgcaaatgac acggacgtct tcgtccttaa caacaccagg ccaccgctgg     1980

gcaattggtt cggttgcacc tggatgaact caactggatt caccaaagtg tgcggagcgc     2040

ccccttgcgt catcggaggg gtgggcaaca acaccttgcg ctgccccact gattgtttcc     2100

gcaagcatcc ggaagccaca tactctcggt gcggctccgg tccctggatt acgcccaggt     2160

gcctggtcga ctacccgtat aggctttggc attatccttg taccatcaac tacaccgtgt     2220

ttaaagtcag gatgtacgtg ggaggggtcg agcacaggct ggaagctgcc tgcaactgga     2280

cgcggggcga ccgttgtaat ctggatgaca gggacaggtc cgagctcagc ccgctgctgc     2340

tgtccactac gcagtggcag gtcctcccgt gttccttcac gaccctgcca gccttgtcca     2400

ccggcctcat ccacctccac caaaacatcg tggacgtgca atacttgtac ggggtgggat     2460

caagcatcgc gtcctgggcc atcaagtggg aatacgtcgt tctcttgttc cttctgcttg     2520

cagacgcgcg cgtctgctcc tgcttgtgga tgatgttact catatcccaa gtggaggcgg     2580

ctttggagaa cctcgtagta ctcaatgcag catccctggc cgggacacac ggtcttgtat     2640

ccttcctcgt gttcttctgc tttgcatggt atctgaaggg taagtgggtg cccggagcgg     2700

tctacgccct ctacgggatg tggcctctcc tcttgctcct gttagcgttg ccccagcggg     2760

catacgcact ggacacggag gtggccgcgt cgtgtggcgg cgttgttctt gtcgggttaa     2820

tggcgctgac tctgtcacca tattacaagc gctatatcag ctggtgcttg tggtggcttc     2880

agtatttcct gaccagaata gaagcgcaac tgcacgtgtg gattccccct ctcaacgtcc     2940

ggggggggcg cgatgccgtc atcttactca tgtgtgttgt gcacccggct ctggtatttg     3000

acatcaccaa gctactgctg gctgccttcg ggcccctttg gattcttcaa gccagtttgc     3060

ttaaggtacc ctacttcgtg cgcgttcaag gccttctccg gatctgcgcg ctagcgcgga     3120

agatggctgg aggccattac gtgcaaatgg ccatcatcaa gttaggggcg cttactggca     3180

cttatgttta caaccatctc accccccttc gggactgggc gcacaacggc ctgcgagatc     3240

tggccgtggc tgtggagcca gtcgtcttct cccgaatgga gaccaagctt atcacctggg     3300

gggcagacac cgccgcgtgc ggtgacatca tcaacggctt gcccgtctcc gcccggaggg     3360

gccgggagat actgctcggg ccagccgatg gaatggtctc caaggggtgg agattgctgg     3420

cgcccatcac ggcgtacgcc cagcaaacga ggggcctcct agggtgtata atcaccagtc     3480

tgaccggccg ggacaaaaac caagtggagg gtgagatcca gattgtgtca actgctgccc     3540

aaaccttcct ggcaacgtgc atcaacgggg tttgctggac cgtctaccac ggggccggaa     3600

cgaggaccat cgcatcaccc aagggtccgg ttatccaaat gtataccaat gtggacaaag     3660

accttgtggg ctggcccgct cctcaaggtg cccgctcact gacaccctgt acctgcggct     3720

cctcggacct ttacctggtc acgaggcacg ccgatgtcat tcccgtgcgc cggcggggtg     3780

atagcagggg cagcctgctt tcgccccggc ccatttccta cttgaaaggc tcctcggggg     3840

gtccgctgct gtgccccgcg ggacacgccg taggcttatt cagggccgcg gtgtgcaccc     3900

gtggagtggc taaggcggtg gacttcatcc ctgtggagaa cctagagaca accatgaggt     3960

ccccggtgtt cacggacaac tcctctccac cagcagtgcc ccagagcttc caggtgggcc     4020

acctgcatgc tcccaccggc agcggcaaaa gcaccaaggt cccggctgca tacgcagctc     4080

agggctataa ggtgctagtg ctcaacccct ctgtcgctgc aacactgggc tttggtgctt     4140

acatgtccaa ggcccatggg gtcgatccta atatcaggac cggggtgaga acaattacca     4200

ctggcagccc catcacgtac tccacctacg gcaagttcct tgccgacggc gggtgttcag     4260

ggggtgctta tgacataata atttgtgacg agtgccactc cacggatgcc acatccatct     4320

tgggcatcgg caccgttctt gaccaagcag agaccgcggg ggcgagactg gttgtgctcg     4380

ccaccgctac ccctccgggc tccatcaccg tgccccatcc taacatcgag gaggttgctc     4440

tgtccactac cggagagatc cctttttacg gcaaggctat ccccctcgag gcgatcaagg     4500

gggggagaca tctcatcttc tgtcactcaa agaagaagtg cgacgagctc gccgcaaagc     4560

tggtcgcatt gggcatcaat gccgtggcct actaccgcgg tcttgacgtg tctgtcatcc     4620

caaccagcgg cgatgttgtc gtcgtggcga ccgatgctct tatgactggc tataccggcg     4680

actttgactc ggtgatagac tgcaacacgt gtgtcaccca gacagtcgac ctcagccttg     4740

accctacctt caccattgag acgaccacgc tcccccagga cgctgtctcc cgcacacaac     4800

gccggggcag gactggcagg gggaagccag gcatctacag attcgtggca ctgggggagc     4860

gcccctccgg catgttcgac tcgtccgttc tctgtgagtg ctatgacgcg ggctgtgctt     4920

ggtatgagct cacgcccgcc gagactacag ttagactacg agcgtacatg aacaccccgg     4980

ggctccctgt gtgccaggac catcttgaat tttgggaggg cgtctttaca ggcctcaccc     5040

atatagatgc ccatttccta tctcagacaa agcagagcgg ggaaaacttt ccttacctgg     5100

tagcatacca agcaaccgtg tgcgctaggg ctcaagcccc tcccccatcg tgggaccaga     5160

tgtggaagtg tttgactcgc ctcaagccca ccctccatgg gccaacaccc ttgctataca     5220

gactgggcgc tgttcagaat gaagtcaccc tgacgcaccc aatcaccaaa tacatcatga     5280

catgcatgtc ggccgacctg gaggtcgtca cgagcacctg ggtgctcgtc ggcggcgtcc     5340

tggccgcttt ggcctcgtat tgcctgtcaa caggctgcgt ggtcatagtg ggcaggattg     5400

tcctgtctgg gaagccggca attatacctg acagggaagt tctctaccgg gagttcgatg     5460

agatggaaga gtgctctcag cacttaccgt acatcgagca agggatgatg ctcgccgagc     5520

agttcaagca gaaggccctc ggcctcctgc agaccgcgtc ccgtcaggca gaggttgtcg     5580

cccctgctgt ccagaccaac tggcaaaaac tcgaggcctt ctgggcgaag catatgtgga     5640

acttcatcag tgggatacac tacttggcgg gcttgtcaac gttgcctggt aaccccgcca     5700

ttgcttcatt gatggctttt acagctgctg tcaccagccc actaaccact agccaaaccc     5760

tcctcttcaa catactgggg gggtgggtgg ctgcccagct tgccgccccc ggtgccgcca     5820

ccgcctttgt gggcgctggc ttagccggcg ccgcaatcgg cagtgttgga ctggggaagg     5880

tcctcgtgga cattctagca gggtatggcg cgggcgtggc gggagctctt gtagcattca     5940

agatcatgag cggtgaggtc ccctccacgg aggacctagt caacctgctg cccgccatcc     6000

tctcgcctgg agcccttgta gtcggtgtgg tctgcgcagc aatactgcgc cggcacgtcg     6060

gcccgggcga gggggcagtg caatggatga accggctaat cgccttcgcc tcccggggga     6120

accatgtttc ccccacgcac tatgtgccgg agagcgatgc agctgcccgc gtcactacca     6180

tactcagcag cctcactgta acccagctcc tgaggcgact gcaccagtgg ataagctcgg     6240

agtgtaccac tccatgctcc ggttcctggc tgagggacat ctgggactgg atatgcgagg     6300

tgctgagcga ctttaagacc tggctgaaag ccaagctcat gccgcaactg cctgggattc     6360

cctttgtgtc ctgccagcgt gggtataagg gggtctggcg aggggacggc atcatgcaca     6420

ctcgctgcca ctgtggagct gagataactg gacatgtcaa aaacgggacg atgaggatcg     6480

ttggtcctaa gacttgcagg aacatgtgga gtgggacttt ccccattaac gcctacacca     6540

cgggcccctg tactcccctt cctgcgccga actatacgtt cgcgctgtgg agggtgtctg     6600

cagaggaata cgtggagata aggcaggtgg gggacttcca ctacgtgacg ggtatgacta     6660

ctgacaacct taaatgcccg tgccaggtcc catcgcccga atttttcaca gaattggacg     6720

gggtgcgcct acataggttt gcgccccctt gcaagcccct gctgcgggag gaggtgtcat     6780

tcagagtggg actccacgag tacccggtgg ggtcgcaatt accttgcgag cccgaaccgg     6840

acgtggccgt gttgacgtcc atgctcactg atccctccca tataacagca gaggcggccg     6900

ggagaaggtt ggcgagggga tcacccccct ctatggccag ctcctcggct agccaactgt     6960

ccgctccatc tctcagggca acttgcacta ccaaccatga ctcccctgat gctgagctca     7020

tagaggccaa cctcctatgg aggcaggaga tgggcggcaa catcaccagg gttgagtcag     7080

agaacaaagt ggtgattctg gactccttcg atccgcttgt ggcagaggag gatgagcggg     7140

aggtctccgt gcccgcagag atactgcgga agtctcggaa attcacccca gccctaccca     7200

tttgggcgcg gccggactat aaccccccgc tggtggagcc gtggaaaaag cctgactacg     7260

aaccacctgt ggtccatggc tgcccgcttc cacctccaca gtcccctcct gtgcctccac     7320

ctcggaagaa gcggacggtg atcctcaccg aatcaaccct acctactgcc ttggccgagc     7380

ttgccaccaa aagttttggc agctcctcaa cttccggcat tacgggcgac gacacgacaa     7440

catcccctga gcccgcctcc tctagctgcc ctcccgactc cgacgctgag tcctattctt     7500

ccatgccccc tctggagggg gagcctgggg atccggatct cagcgacggg tcatggtcga     7560

cggtcagtag tgaggccgac aaggaggatg tcgtgtgctg ctccatgtca tactcctgga     7620

ccggggctct aataactccc tgtagccccg aagaggaaaa gttgccaatc aaccctttga     7680

gtaactcgct gttgcgatac cataacaagg tgtactgtac aacatcaaag agcgcctcac     7740

agagggctaa aaaggtaact tttgacagga cgcaagtgct cgacgcccat tatgactcag     7800

tcttaaagga catcaagcta gcggcttcca aggtcagcgc aaggctcctc accttggagg     7860

aggcgtgcca gttgactcca ccccattctg caagatccaa gtatggattc ggggccaagg     7920

aggtccgcag cttgtccggg agggccgtta accacatcaa gtccgtgtgg aaggacctcc     7980

tggaagaccc acaaacacca attcccacaa ccatcatggc caaaaatgag gtgttctgcg     8040

tggaccccgc caaggggggt aagaaaccag ctcgcctcat cgtttaccct gacctcggcg     8100

tccgggtctg cgagaaaatg gccctctatg acattacaca aaagcttcct caggcggtaa     8160

tgggagcttc ctatggcttc cagtactccc ctgcccaacg ggtggagtat ctcttgaaag     8220

catgggcgga aaagaaggac cccatgggtt tttcgtatga tacccgatgc ttcgactcaa     8280

ccgtcactga gagagacatc aggaccgagg agtccatata ccaggcctgc tccctgcccg     8340

aggaggcccg cactgccata cactcgctga ctgagagact ttacgtagga gggcccatgt     8400

tcaacagcaa gggtcaaacc tgcggttaca gacgttgccg cgccagcggg gtgctaacca     8460

ctagcatggg taacaccatc acatgctatg tgaaagccct agcggcctgc aaggctgcgg     8520

ggatagttgc gcccacaatg ctggtatgcg gcgatgacct agtagtcatc tcagaaagcc     8580

aggggactga ggaggacgag cggaacctga gagccttcac ggaggccatg accaggtact     8640

ctgcccctcc tggtgatccc cccagaccgg aatatgacct ggagctaata acatcctgtt     8700

cctcaaatgt gtctgtggcg ttgggcccgc ggggccgccg cagatactac ctgaccagag     8760

acccaaccac tccactcgcc cgggctgcct gggaaacagt tagacactcc cctatcaatt     8820

catggctggg aaacatcatc cagtatgctc caaccatatg ggttcgcatg gtcctaatga     8880

cacacttctt ctccattctc atggtccaag acaccctgga ccagaacctc aactttgaga     8940

tgtatggatc agtatactcc gtgaatcctt tggaccttcc agccataatt gagaggttac     9000

acgggcttga cgccttttct atgcacacat actctcacca cgaactgacg cgggtggctt     9060

cagccctcag aaaacttggg gcgccacccc tcagggtgtg gaagagtcgg gctcgcgcag     9120

tcagggcgtc cctcatctcc cgtggaggga aagcggccgt ttgcggccga tatctcttca     9180

attgggcggt gaagaccaag ctcaaactca ctccattgcc ggaggcgcgc ctactggact     9240

tatccagttg gttcaccgtc ggcgccggcg ggggcggcat ttttcacagc gtgtcgcgcg     9300

cccgaccccg ctcattactc ttcggcctac tcctactttt cgtaggggta ggcctcttcc     9360

tactccccgc tcggtagagc ggcacacact aggtacactc catagctaac tgttcctttt     9420

tttttttttt tttttttttt tttttttttt tttttttttc tttttttttt ttttccctct     9480

ttcttccctt ctcatcttat tctactttct ttcttggtgg ctccatctta gccctagtca     9540

cggctagctg tgaaaggtcc gtgagccgca tgactgcaga gagtgccgta actggtctct     9600

ctgcagatca tgt                                                        9613


<210>  136
<211>  9613
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid

<400>  136
gccagccccc tgatgggggc gacactccac catgaatcac tcccctgtga ggaactactg       60

tcttcacgca gaaagcgtct agccatggcg ttagtatgag tgtcgtgcag cctccaggac      120

cccccctccc gggagagcca tagtggtctg cggaaccggt gagtacaccg gaattgccag      180

gacgaccggg tcctttcttg gatcaacccg ctcaatgcct ggagatttgg gcgtgccccc      240

gcaagactgc tagccgagta gtgttgggtc gcgaaaggcc ttgtggtact gcctgatagg      300

gtgcttgcga gtgccccggg aggtctcgta gaccgtgcac catgagcacg aatcctaaac      360

ctcaaagaaa aaccaaacgt aacaccaacc gtcgcccaca ggacgtcaag ttcccgggtg      420

gcggtcagat cgttggtgga gtttacttgt tgccgcgcag gggccctaga ttgggtgtgc      480

gcgcgacgag gaagacttcc gagcggtcgc aacctcgagg tagacgtcag cctatcccca      540

aggcgcgtcg gcccgagggc aggacctggg ctcagcccgg gtacccttgg cccctctatg      600

gcaatgaggg ttgcgggtgg gcgggatggc tcctgtctcc ccgtggctct cggcctagct      660

ggggccccac ggacccccgg cgtaggtcgc gcaatttggg taaggtcatc gataccctta      720

cgtgcggctt cgccgacctc atggggtaca taccgctcgt cggcgcccct cttggaggcg      780

ctgccagggc cctggcgcat ggcgtccggg ttttggaaga cggcgtgaac tatgcaacag      840

ggaaccttcc tggttgctct ttctctattt tccttctggc cctgctctct tgtctgactg      900

gacccgcttc agcctaccaa gtgcgcaact ccacggggct ttaccatgtc accaatgatt      960

gccccaactc gagcattgtg ttcgaggcgg ctgatgccat cctgcacact ccggggtgtg     1020

tcccttgcgt acgcgagggt aacgcctcga ggtgttgggt ggcggtaacc cccacggtgg     1080

ccaccaggga tggcaaactc cccacaacgc agcttcgacg tcacatcgat ctgcttgtcg     1140

ggagcgccac cctctgctcg gccctttacg tgggggacct gtgcgggtct gtctttcttg     1200

ttggtcaact gttcaccttc tctcccaggc gccactggac gacgcaagat tgcaattgtt     1260

ctatctaccc cggccatatt tcaggtcacc gtatggcatg ggatatgatg atgaactggt     1320

cccctacggc ggcgttgttg gtagctcagc tgctccggat cccacaagcc atcctggaca     1380

tgatcgctgg tgctcactgg ggagtcctgg cgggcatggc gtatttctcc atggtgggga     1440

actgggcgaa ggttctggta gtgctgctgc tatttgccgg cgtcgacgcg gaaacctacg     1500

tcaccggggg aagtgccgcc cgtactacgg ctggacttgc tagtcttttc tcaccaggcg     1560

ccaagcagaa catccagctg gtcaacacca acggcagttg gcacatcaat agcacggcct     1620

tgaactgcaa tgacagcctc aacaccggct ggatagcagg acttttctat caccacaaat     1680

tcaactcttc gggctgttcc gagaggttag ccagctgccg accccttacc gattttgccc     1740

agggctgggg ccctatcagt cacgccgacg gaagtggccc cgaccaacgc ccctactgct     1800

ggcactaccc tccaaaacct tgtggtattg tgcccgcaaa gagcgtgtgt ggcccggtat     1860

attgtttcac tcccagtccc gtggtggtgg gaacgaccga caggtcgggc gcgcctacct     1920

acagctgggg tgcaaatgac acggacgtct tcgtccttaa caacaccagg ccaccgctgg     1980

gcaattggtt cggttgcacc tggatgaact caactggatt caccaaagtg tgcggagcgc     2040

ccccttgcgt catcggaggg gtgggcaaca acaccttgcg ctgccccact gattgtttcc     2100

gcaagcatcc ggaagccaca tactctcggt gcggctccgg tccctggatt acgcccaggt     2160

gcctggtcga ctacccgtat aggctttggc attatccttg taccatcaac tacaccgtgt     2220

ttaaagtcag gatgtacgtg ggaggggtcg agcacaggct ggaagctgcc tgcaactgga     2280

cgcggggcga ccgttgtaat ctggatgaca gggacaggtc cgagctcagc ccgctgctgc     2340

tgtccactac gcagtggcag gtcctcccgt gttccttcac gaccctgcca gccttgtcca     2400

ccggcctcat ccacctccac caaaacatcg tggacgtgca atacttgtac ggggtgggat     2460

caagcatcgc gtcctgggcc atcaagtggg aatacgtcgt tctcttgttc cttctgcttg     2520

cagacgcgcg cgtctgctcc tgcttgtgga tgatgttact catatcccaa gtggaggcgg     2580

ctttggagaa cctcgtagta ctcaatgcag catccctggc cgggacacac ggtcttgtat     2640

ccttcctcgt gttcttctgc tttgcatggt atctgaaggg taagtgggtg cccggagcgg     2700

tctacgccct ctacgggatg tggcctctcc tcttgctcct gttagcgttg ccccagcggg     2760

catacgcact ggacacggag gtggccgcgt cgtgtggcgg cgttgttctt gtcgggttaa     2820

tggcgctgac tctgtcacca tattacaagc gctatatcag ctggtgcttg tggtggcttc     2880

agtatttcct gaccagaata gaagcgcaac tgcacgtgtg gattccccct ctcaacgtcc     2940

ggggggggcg cgatgccgtc atcttactca tgtgtgttgt gcacccggct ctggtatttg     3000

acatcaccaa gctactgctg gctgccttcg ggcccctttg gattcttcaa gccagtttgc     3060

ttaaggtacc ctacttcgtg cgcgttcaag gccttctccg gatctgcgcg ctagcgcgga     3120

agatggctgg aggccattac gtgcaaatgg ccatcatcaa gttaggggcg cttactggca     3180

cttatgttta caaccatctc accccccttc gggactgggc gcacaacggc ctgcgagatc     3240

tggccgtggc tgtggagcca gtcgtcttct cccgaatgga gaccaagctt atcacctggg     3300

gggcagacac cgccgcgtgc ggtgacatca tcaacggctt gcccgtctcc gcccggaggg     3360

gccgggagat actgctcggg ccagccgatg gaatggtctc caaggggtgg agattgctgg     3420

cgcccatcac ggcgtacgcc cagcaaacga ggggcctcct agggtgtata atcaccagtc     3480

tgaccggccg ggacaaaaac caagtggagg gtgagatcca gattgtgtca actgctgccc     3540

aaaccttcct ggcaacgtgc atcaacgggg tttgctggac cgtctaccac ggggccggaa     3600

cgaggaccat cgcatcaccc aagggtccgg ttatccaaat gtataccaat gtggacaaag     3660

accttgtggg ctggcccgct cctcaaggtg cccgctcact gacaccctgt acctgcggct     3720

cctcggacct ttacctggtc acgaggcacg ccgatgtcat tcccgtgcgc cggcggggtg     3780

atagcagggg cagcctgctt tcgccccggc ccatttccta cttgaaaggc tcctcggggg     3840

gtccgctgct gtgccccgcg ggacacgccg taggcttatt cagggccgcg gtgtgcaccc     3900

gtggagtggc taaggcggtg gacttcatcc ctgtggagaa cctagagaca accatgaggt     3960

ccccggtgtt cacggacaac tcctctccac cagcagtgcc ccagagcttc caggtgggcc     4020

acctgcatgc tcccaccggc agcggcaaaa gcaccaaggt cccggctgca tacgcagctc     4080

agggctataa ggtgctagtg ctcaacccct ctgtcgctgc aacactgggc tttggtgctt     4140

acatgtccaa ggcccatggg gtcgatccta atatcaggac cggggtgaga acaattacca     4200

ctggcagccc catcacgtac tccacctacg gcaagttcct tgccgacggc gggtgttcag     4260

ggggtgctta tgacataata atttgtgacg agtgccactc cacggatgcc acatccatct     4320

tgggcatcgg caccgttctt gaccaagcag agaccgcggg ggcgagactg gttgtgctcg     4380

ccaccgctac ccctccgggc tccatcaccg tgccccatcc taacatcgag gaggttgctc     4440

tgtccactac cggagagatc cctttttacg gcaaggctat ccccctcgag gcgatcaagg     4500

gggggagaca tctcatcttc tgtcactcaa agaagaagtg cgacgagctc gccgcaaagc     4560

tggtcgcatt gggcatcaat gccgtggcct actaccgcgg tcttgacgtg tctgtcatcc     4620

caaccagcgg cgatgttgtc gtcgtggcga ccgatgctct tatgactggc tataccggcg     4680

actttgactc ggtgatagac tgcaacacgt gtgtcaccca gacagtcgac ctcagccttg     4740

accctacctt caccattgag acgaccacgc tcccccagga cgctgtctcc cgcacacaac     4800

gccggggcag gactggcagg gggaagccag gcatctacag attcgtggca ctgggggagc     4860

gcccctccgg catgttcgac tcgtccgttc tctgtgagtg ctatgacgcg ggctgtgctt     4920

ggtatgagct cacgcccgcc gagactacag ttagactacg agcgtacatg aacaccccgg     4980

ggctccctgt gtgccaggac catcttgaat tttgggaggg cgtctttaca ggcctcaccc     5040

atatagatgc ccatttccta tctcagacaa agcagagcgg ggaaaacttt ccttacctgg     5100

tagcatacca agcaaccgtg tgcgctaggg ctcaagcccc tcccccatcg tgggaccaga     5160

tgtggaagtg tttgactcgc ctcaagccca ccctccatgg gccaacaccc ttgctataca     5220

gactgggcgc tgttcagaat gaagtcaccc tgacgcaccc aatcaccaaa tacatcatga     5280

catgcatgtc ggccgacctg gaggtcgtca cgagcacctg ggtgctcgtc ggcggcgtcc     5340

tggccgcttt ggcctcgtat tgcctgtcaa caggctgcgt ggtcatagtg ggcaggattg     5400

tcctgtctgg gaagccggca attatacctg acagggaagt tctctaccgg gagttcgatg     5460

agatggaaga gtgctctcag cacttaccgt acatcgagca agggatgatg ctcgccgagc     5520

agttcaagca gaaggccctc ggcctcctgc agaccgcgtc ccgtcaggca gaggttgtcg     5580

cccctgctgt ccagaccaac tggcaaaaac tcgaggcctt ctgggcgaag catatgtgga     5640

acttcatcag tgggatacaa tacttggcgg gcttgtcaac gttgcctggt aaccccgcca     5700

ttgcttcatt gatggctttt acagctgctg tcaccagccc actaaccact agccaaaccc     5760

tcctcttcaa catactgggg gggtgggtgg ctgcccagct tgccgccccc ggtgccgcca     5820

ccgcctttgt gggcgctggc ttagccggcg ccgcaatcgg cagtgttgga ctggggaagg     5880

tcctcgtgga cattctagca gggtatggcg cgggcgtggc gggagctctt gtagcattca     5940

agatcatgag cggtgaggtc ccctccacgg aggacctagt caacctgctg cccgccatcc     6000

tctcgcctgg agcccttgta gtcggtgtgg tctgcgcagc aatactgcgc cggcacgtcg     6060

gcccgggcga gggggcagtg caatggatga accggctaat cgccttcgcc tcccggggga     6120

accatgtttc ccccacgcac tatgtgccgg agagcgatgc agctgcccgc gtcactacca     6180

tactcagcag cctcactgta acccagctcc tgaggcgact gcaccagtgg ataagctcgg     6240

agtgtaccac tccatgctcc ggttcctggc tgagggacat ctgggactgg atatgcgagg     6300

tgctgagcga ctttaagacc tggctgaaag ccaagctcat gccgcaactg cctgggattc     6360

cctttgtgtc ctgccagcgt gggtataagg gggtctggcg aggggacggc atcatgcaca     6420

ctcgctgcca ctgtggagct gagataactg gacatgtcaa aaacgggacg atgaggatcg     6480

ttggtcctaa gacttgcagg aacatgtgga gtgggacttt ccccattaac gcctacacca     6540

cgggcccctg tactcccctt cctgcgccga actatacgtt cgcgctgtgg agggtgtctg     6600

cagaggaata cgtggagata aggcaggtgg gggacttcca ctacgtgacg ggtatgacta     6660

ctgacaacct taaatgcccg tgccaggtcc catcgcccga atttttcaca gaattggacg     6720

gggtgcgcct acataggttt gcgccccctt gcaagcccct gctgcgggag gaggtgtcat     6780

tcagagtggg actccacgag tacccggtgg ggtcgcaatt accttgcgag cccgaaccgg     6840

acgtggccgt gttgacgtcc atgctcactg atccctccca tataacagca gaggcggccg     6900

ggagaaggtt ggcgagggga tcacccccct ctatggccag ctcctcggct agccaactgt     6960

ccgctccatc tctcagggca acttgcacta ccaaccatga ctcccctgat gctgagctca     7020

tagaggccaa cctcctatgg aggcaggaga tgggcggcaa catcaccagg gttgagtcag     7080

agaacaaagt ggtgattctg gactccttcg atccgcttgt ggcagaggag gatgagcggg     7140

aggtctccgt gcccgcagag atactgcgga agtctcggaa attcacccca gccctaccca     7200

tttgggcgcg gccggactat aaccccccgc tggtggagcc gtggaaaaag cctgactacg     7260

aaccacctgt ggtccatggc tgcccgcttc cacctccaca gtcccctcct gtgcctccac     7320

ctcggaagaa gcggacggtg atcctcaccg aatcaaccct acctactgcc ttggccgagc     7380

ttgccaccaa aagttttggc agctcctcaa cttccggcat tacgggcgac gacacgacaa     7440

catcccctga gcccgcctcc tctagctgcc ctcccgactc cgacgctgag tcctattctt     7500

ccatgccccc tctggagggg gagcctgggg atccggatct cagcgacggg tcatggtcga     7560

cggtcagtag tgaggccgac aaggaggatg tcgtgtgctg ctccatgtca tactcctgga     7620

ccggggctct aataactccc tgtagccccg aagaggaaaa gttgccaatc aaccctttga     7680

gtaactcgct gttgcgatac cataacaagg tgtactgtac aacatcaaag agcgcctcac     7740

agagggctaa aaaggtaact tttgacagga cgcaagtgct cgacgcccat tatgactcag     7800

tcttaaagga catcaagcta gcggcttcca aggtcagcgc aaggctcctc accttggagg     7860

aggcgtgcca gttgactcca ccccattctg caagatccaa gtatggattc ggggccaagg     7920

aggtccgcag cttgtccggg agggccgtta accacatcaa gtccgtgtgg aaggacctcc     7980

tggaagaccc acaaacacca attcccacaa ccatcatggc caaaaatgag gtgttctgcg     8040

tggaccccgc caaggggggt aagaaaccag ctcgcctcat cgtttaccct gacctcggcg     8100

tccgggtctg cgagaaaatg gccctctatg acattacaca aaagcttcct caggcggtaa     8160

tgggagcttc ctatggcttc cagtactccc ctgcccaacg ggtggagtat ctcttgaaag     8220

catgggcgga aaagaaggac cccatgggtt tttcgtatga tacccgatgc ttcgactcaa     8280

ccgtcactga gagagacatc aggaccgagg agtccatata ccaggcctgc tccctgcccg     8340

aggaggcccg cactgccata cactcgctga ctgagagact ttacgtagga gggcccatgt     8400

tcaacagcaa gggtcaaacc tgcggttaca gacgttgccg cgccagcggg gtgctaacca     8460

ctagcatggg taacaccatc acatgctatg tgaaagccct agcggcctgc aaggctgcgg     8520

ggatagttgc gcccacaatg ctggtatgcg gcgatgacct agtagtcatc tcagaaagcc     8580

aggggactga ggaggacgag cggaacctga gagccttcac ggaggccatg accaggtact     8640

ctgcccctcc tggtgatccc cccagaccgg aatatgacct ggagctaata acatcctgtt     8700

cctcaaatgt gtctgtggcg ttgggcccgc ggggccgccg cagatactac ctgaccagag     8760

acccaaccac tccactcgcc cgggctgcct gggaaacagt tagacactcc cctatcaatt     8820

catggctggg aaacatcatc cagtatgctc caaccatatg ggttcgcatg gtcctaatga     8880

cacacttctt ctccattctc atggtccaag acaccctgga ccagaacctc aactttgaga     8940

tgtatggatc agtatactcc gtgaatcctt tggaccttcc agccataatt gagaggttac     9000

acgggcttga cgccttttct atgcacacat actctcacca cgaactgacg cgggtggctt     9060

cagccctcag aaaacttggg gcgccacccc tcagggtgtg gaagagtcgg gctcgcgcag     9120

tcagggcgtc cctcatctcc cgtggaggga aagcggccgt ttgcggccga tatctcttca     9180

attgggcggt gaagaccaag ctcaaactca ctccattgcc ggaggcgcgc ctactggact     9240

tatccagttg gttcaccgtc ggcgccggcg ggggcggcat ttttcacagc gtgtcgcgcg     9300

cccgaccccg ctcattactc ttcggcctac tcctactttt cgtaggggta ggcctcttcc     9360

tactccccgc tcggtagagc ggcacacact aggtacactc catagctaac tgttcctttt     9420

tttttttttt tttttttttt tttttttttt tttttttttc tttttttttt ttttccctct     9480

ttcttccctt ctcatcttat tctactttct ttcttggtgg ctccatctta gccctagtca     9540

cggctagctg tgaaaggtcc gtgagccgca tgactgcaga gagtgccgta actggtctct     9600

ctgcagatca tgt                                                        9613


<210>  137
<211>  9613
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid

<400>  137
gccagccccc tgatgggggc gacactccac catgaatcac tcccctgtga ggaactactg       60

tcttcacgca gaaagcgtct agccatggcg ttagtatgag tgtcgtgcag cctccaggac      120

cccccctccc gggagagcca tagtggtctg cggaaccggt gagtacaccg gaattgccag      180

gacgaccggg tcctttcttg gatcaacccg ctcaatgcct ggagatttgg gcgtgccccc      240

gcaagactgc tagccgagta gtgttgggtc gcgaaaggcc ttgtggtact gcctgatagg      300

gtgcttgcga gtgccccggg aggtctcgta gaccgtgcac catgagcacg aatcctaaac      360

ctcaaagaaa aaccaaacgt aacaccaacc gtcgcccaca ggacgtcaag ttcccgggtg      420

gcggtcagat cgttggtgga gtttacttgt tgccgcgcag gggccctaga ttgggtgtgc      480

gcgcgacgag gaagacttcc gagcggtcgc aacctcgagg tagacgtcag cctatcccca      540

aggcgcgtcg gcccgagggc aggacctggg ctcagcccgg gtacccttgg cccctctatg      600

gcaatgaggg ttgcgggtgg gcgggatggc tcctgtctcc ccgtggctct cggcctagct      660

ggggccccac ggacccccgg cgtaggtcgc gcaatttggg taaggtcatc gataccctta      720

cgtgcggctt cgccgacctc atggggtaca taccgctcgt cggcgcccct cttggaggcg      780

ctgccagggc cctggcgcat ggcgtccggg ttttggaaga cggcgtgaac tatgcaacag      840

ggaaccttcc tggttgctct ttctctattt tccttctggc cctgctctct tgtctgactg      900

gacccgcttc agcctaccaa gtgcgcaact ccacggggct ttaccatgtc accaatgatt      960

gccccaactc gagcattgtg ttcgaggcgg ctgatgccat cctgcacact ccggggtgtg     1020

tcccttgcgt acgcgagggt aacgcctcga ggtgttgggt ggcggtaacc cccacggtgg     1080

ccaccaggga tggcaaactc cccacaacgc agcttcgacg tcacatcgat ctgcttgtcg     1140

ggagcgccac cctctgctcg gccctttacg tgggggacct gtgcgggtct gtctttcttg     1200

ttggtcaact gttcaccttc tctcccaggc gccactggac gacgcaagat tgcaattgtt     1260

ctatctaccc cggccatatt tcaggtcacc gtatggcatg ggatatgatg atgaactggt     1320

cccctacggc ggcgttgttg gtagctcagc tgctccggat cccacaagcc atcctggaca     1380

tgatcgctgg tgctcactgg ggagtcctgg cgggcatggc gtatttctcc atggtgggga     1440

actgggcgaa ggttctggta gtgctgctgc tatttgccgg cgtcgacgcg gaaacctacg     1500

tcaccggggg aagtgccgcc cgtactacgg ctggacttgc tagtcttttc tcaccaggcg     1560

ccaagcagaa catccagctg gtcaacacca acggcagttg gcacatcaat agcacggcct     1620

tgaactgcaa tgacagcctc aacaccggct ggatagcagg acttttctat caccacaaat     1680

tcaactcttc gggctgttcc gagaggttag ccagctgccg accccttacc gattttgccc     1740

agggctgggg ccctatcagt cacgccgacg gaagtggccc cgaccaacgc ccctactgct     1800

ggcactaccc tccaaaacct tgtggtattg tgcccgcaaa gagcgtgtgt ggcccggtat     1860

attgtttcac tcccagtccc gtggtggtgg gaacgaccga caggtcgggc gcgcctacct     1920

acagctgggg tgcaaatgac acggacgtct tcgtccttaa caacaccagg ccaccgctgg     1980

gcaattggtt cggttgcacc tggatgaact caactggatt caccaaagtg tgcggagcgc     2040

ccccttgcgt catcggaggg gtgggcaaca acaccttgcg ctgccccact gattgtttcc     2100

gcaagcatcc ggaagccaca tactctcggt gcggctccgg tccctggatt acgcccaggt     2160

gcctggtcga ctacccgtat aggctttggc attatccttg taccatcaac tacaccgtgt     2220

ttaaagtcag gatgtacgtg ggaggggtcg agcacaggct ggaagctgcc tgcaactgga     2280

cgcggggcga ccgttgtaat ctggatgaca gggacaggtc cgagctcagc ccgctgctgc     2340

tgtccactac gcagtggcag gtcctcccgt gttccttcac gaccctgcca gccttgtcca     2400

ccggcctcat ccacctccac caaaacatcg tggacgtgca atacttgtac ggggtgggat     2460

caagcatcgc gtcctgggcc atcaagtggg aatacgtcgt tctcttgttc cttctgcttg     2520

cagacgcgcg cgtctgctcc tgcttgtgga tgatgttact catatcccaa gtggaggcgg     2580

ctttggagaa cctcgtagta ctcaatgcag catccctggc cgggacacac ggtcttgtat     2640

ccttcctcgt gttcttctgc tttgcatggt atctgaaggg taagtgggtg cccggagcgg     2700

tctacgccct ctacgggatg tggcctctcc tcttgctcct gttagcgttg ccccagcggg     2760

catacgcact ggacacggag gtggccgcgt cgtgtggcgg cgttgttctt gtcgggttaa     2820

tggcgctgac tctgtcacca tattacaagc gctatatcag ctggtgcttg tggtggcttc     2880

agtatttcct gaccagaata gaagcgcaac tgcacgtgtg gattccccct ctcaacgtcc     2940

ggggggggcg cgatgccgtc atcttactca tgtgtgttgt gcacccggct ctggtatttg     3000

acatcaccaa gctactgctg gctgccttcg ggcccctttg gattcttcaa gccagtttgc     3060

ttaaggtacc ctacttcgtg cgcgttcaag gccttctccg gatctgcgcg ctagcgcgga     3120

agatggctgg aggccattac gtgcaaatgg ccatcatcaa gttaggggcg cttactggca     3180

cttatgttta caaccatctc accccccttc gggactgggc gcacaacggc ctgcgagatc     3240

tggccgtggc tgtggagcca gtcgtcttct cccgaatgga gaccaagctt atcacctggg     3300

gggcagacac cgccgcgtgc ggtgacatca tcaacggctt gcccgtctcc gcccggaggg     3360

gccgggagat actgctcggg ccagccgatg gaatggtctc caaggggtgg agattgctgg     3420

cgcccatcac ggcgtacgcc cagcaaacga ggggcctcct agggtgtata atcaccagtc     3480

tgaccggccg ggacaaaaac caagtggagg gtgagatcca gattgtgtca actgctgccc     3540

aaaccttcct ggcaacgtgc atcaacgggg tttgctggac cgtctaccac ggggccggaa     3600

cgaggaccat cgcatcaccc aagggtccgg ttatccaaat gtataccaat gtggacaaag     3660

accttgtggg ctggcccgct cctcaaggtg cccgctcact gacaccctgt acctgcggct     3720

cctcggacct ttacctggtc acgaggcacg ccgatgtcat tcccgtgcgc cggcggggtg     3780

atagcagggg cagcctgctt tcgccccggc ccatttccta cttgaaaggc tcctcggggg     3840

gtccgctgct gtgccccgcg ggacacgccg taggcttatt cagggccgcg gtgtgcaccc     3900

gtggagtggc taaggcggtg gacttcatcc ctgtggagaa cctagagaca accatgaggt     3960

ccccggtgtt cacggacaac tcctctccac cagcagtgcc ccagagcttc caggtggccc     4020

acctgcatgc tcccaccggc agcggcaaaa gcaccaaggt cccggctgca tacgcagctc     4080

agggctataa ggtgctagtg ctcaacccct ctgtcgctgc aacactgggc tttggtgctt     4140

acatgtccaa ggcccatggg gtcgatccta atatcaggac cggggtgaga acaattacca     4200

ctggcagccc catcacgtac tccacctacg gcaagttcct tgccgacggc gggtgttcag     4260

ggggtgctta tgacataata atttgtgacg agtgccactc cacggatgcc acatccatct     4320

tgggcatcgg caccgttctt gaccaagcag agaccgcggg ggcgagactg gttgtgctcg     4380

ccaccgctac ccctccgggc tccatcaccg tgccccatcc taacatcgag gaggttgctc     4440

tgtccactac cggagagatc cctttttacg gcaaggctat ccccctcgag gcgatcaagg     4500

gggggagaca tctcatcttc tgtcactcaa agaagaagtg cgacgagctc gccgcaaagc     4560

tggtcgcatt gggcatcaat gccgtggcct actaccgcgg tcttgacgtg tctgtcatcc     4620

caaccagcgg cgatgttgtc gtcgtggcga ccgatgctct tatgactggc tataccggcg     4680

actttgactc ggtgatagac tgcaacacgt gtgtcaccca gacagtcgac ctcagccttg     4740

accctacctt caccattgag acgaccacgc tcccccagga cgctgtctcc cgcacacaac     4800

gccggggcag gactggcagg gggaagccag gcatctacag attcgtggca ctgggggagc     4860

gcccctccgg catgttcgac tcgtccgttc tctgtgagtg ctatgacgcg ggctgtgctt     4920

ggtatgagct cacgcccgcc gagactacag ttagactacg agcgtacatg aacaccccgg     4980

ggctccctgt gtgccaggac catcttgaat tttgggaggg cgtctttaca ggcctcaccc     5040

atatagatgc ccatttccta tctcagacaa agcagagcgg ggaaaacttt ccttacctgg     5100

tagcatacca agcaaccgtg tgcgctaggg ctcaagcccc tcccccatcg tgggaccaga     5160

tgtggaagtg tttgactcgc ctcaagccca ccctccatgg gccaacaccc ttgctataca     5220

gactgggcgc tgttcagaat gaagtcaccc tgacgcaccc aatcaccaaa tacatcatga     5280

catgcatgtc ggccgacctg gaggtcgtca cgagcacctg ggtgctcgtc ggcggcgtcc     5340

tggccgcttt ggcctcgtat tgcctgtcaa caggctgcgt ggtcatagtg ggcaggattg     5400

tcctgtctgg gaagccggca attatacctg acagggaagt tctctaccgg gagttcgatg     5460

agatggaaga gtgctctcag cacttaccgt acatcgagca agggatgatg ctcgccgagc     5520

agttcaagca gaaggccctc ggcctcctgc agaccgcgtc ccgtcaggca gaggttgtcg     5580

cccctgctgt ccagaccaac tggcaaaaac tcgaggcctt ctgggcgaag catatgtgga     5640

acttcatcag tgggatacac tacttggcgg gcttgtcaac gttgcctggt aaccccgcca     5700

ttgcttcatt gatggctttt acagctgctg tcaccagccc actaaccact agccaaaccc     5760

tcctcttcaa catactgggg gggtgggtgg ctgcccagct tgccgccccc ggtgccgcca     5820

ccgcctttgt gggcgctggc ttagccggcg ccgcaatcgg cagtgttgga ctggggaagg     5880

tcctcgtgga cattctagca gggtatggcg cgggcgtggc gggagctctt gtagcattca     5940

agatcatgag cggtgaggtc ccctccacgg aggacctagt caacctgctg cccgccatcc     6000

tctcgcctgg agcccttgta gtcggtgtgg tctgcgcagc aatactgcgc cggcacgtcg     6060

gcccgggcga gggggcagtg caatggatga accggctaat cgccttcgcc tcccggggga     6120

accatgtttc ccccacgcac tatgtgccgg agagcgatgc agctgcccgc gtcactacca     6180

tactcagcag cctcactgta acccagctcc tgaggcgact gcaccagtgg ataagctcgg     6240

agtgtaccac tccatgctcc ggttcctggc tgagggacat ctgggactgg atatgcgagg     6300

tgctgagcga ctttaagacc tggctgaaag ccaagctcat gccgcaactg cctgggattc     6360

cctttgtgtc ctgccagcgt gggtataagg gggtctggcg aggggacggc atcatgcaca     6420

ctcgctgcca ctgtggagct gagataactg gacatgtcaa aaacgggacg atgaggatcg     6480

ttggtcctaa gacttgcagg aacatgtgga gtgggacttt ccccattaac gcctacacca     6540

cgggcccctg tactcccctt cctgcgccga actatacgtt cgcgctgtgg agggtgtctg     6600

cagaggaata cgtggagata aggcaggtgg gggacttcca ctacgtgacg ggtatgacta     6660

ctgacaacct taaatgcccg tgccaggtcc catcgcccga atttttcaca gaattggacg     6720

gggtgcgcct acataggttt gcgccccctt gcaagcccct gctgcgggag gaggtgtcat     6780

tcagagtggg actccacgag tacccggtgg ggtcgcaatt accttgcgag cccgaaccgg     6840

acgtggccgt gttgacgtcc atgctcactg atccctccca tataacagca gaggcggccg     6900

ggagaaggtt ggcgagggga tcacccccct ctatggccag ctcctcggct agccaactgt     6960

ccgctccatc tctcagggca acttgcacta ccaaccatga ctcccctgat gctgagctca     7020

tagaggccaa cctcctatgg aggcaggaga tgggcggcaa catcaccagg gttgagtcag     7080

agaacaaagt ggtgattctg gactccttcg atccgcttgt ggcagaggag gatgagcggg     7140

aggtctccgt gcccgcagag atactgcgga agtctcggaa attcacccca gccctaccca     7200

tttgggcgcg gccggactat aaccccccgc tggtggagcc gtggaaaaag cctgactacg     7260

aaccacctgt ggtccatggc tgcccgcttc cacctccaca gtcccctcct gtgcctccac     7320

ctcggaagaa gcggacggtg atcctcaccg aatcaaccct acctactgcc ttggccgagc     7380

ttgccaccaa aagttttggc agctcctcaa cttccggcat tacgggcgac gacacgacaa     7440

catcccctga gcccgcctcc tctagctgcc ctcccgactc cgacgctgag tcctattctt     7500

ccatgccccc tctggagggg gagcctgggg atccggatct cagcgacggg tcatggtcga     7560

cggtcagtag tgaggccgac aaggaggatg tcgtgtgctg ctccatgtca tactcctgga     7620

ccggggctct aataactccc tgtagccccg aagaggaaaa gttgccaatc aaccctttga     7680

gtaactcgct gttgcgatac cataacaagg tgtactgtac aacatcaaag agcgcctcac     7740

agagggctaa aaaggtaact tttgacagga cgcaagtgct cgacgcccat tatgactcag     7800

tcttaaagga catcaagcta gcggcttcca aggtcagcgc aaggctcctc accttggagg     7860

aggcgtgcca gttgactcca ccccattctg caagatccaa gtatggattc ggggccaagg     7920

aggtccgcag cttgtccggg agggccgtta accacatcaa gtccgtgtgg aaggacctcc     7980

tggaagaccc acaaacacca attcccacaa ccatcatggc caaaaatgag gtgttctgcg     8040

tggaccccgc caaggggggt aagaaaccag ctcgcctcat cgtttaccct gacctcggcg     8100

tccgggtctg cgagaaaatg gccctctatg acattacaca aaagcttcct caggcggtaa     8160

tgggagcttc ctatggcttc cagtactccc ctgcccaacg ggtggagtat ctcttgaaag     8220

catgggcgga aaagaaggac cccatgggtt tttcgtatga tacccgatgc ttcgactcaa     8280

ccgtcactga gagagacatc aggaccgagg agtccatata ccaggcctgc tccctgcccg     8340

aggaggcccg cactgccata cactcgctga ctgagagact ttacgtagga gggcccatgt     8400

tcaacagcaa gggtcaaacc tgcggttaca gacgttgccg cgccagcggg gtgctaacca     8460

ctagcatggg taacaccatc acatgctatg tgaaagccct agcggcctgc aaggctgcgg     8520

ggatagttgc gcccacaatg ctggtatgcg gcgatgacct agtagtcatc tcagaaagcc     8580

aggggactga ggaggacgag cggaacctga gagccttcac ggaggccatg accaggtact     8640

ctgcccctcc tggtgatccc cccagaccgg aatatgacct ggagctaata acatcctgtt     8700

cctcaaatgt gtctgtggcg ttgggcccgc ggggccgccg cagatactac ctgaccagag     8760

acccaaccac tccactcgcc cgggctgcct gggaaacagt tagacactcc cctatcaatt     8820

catggctggg aaacatcatc cagtatgctc caaccatatg ggttcgcatg gtcctaatga     8880

cacacttctt ctccattctc atggtccaag acaccctgga ccagaacctc aactttgaga     8940

tgtatggatc agtatactcc gtgaatcctt tggaccttcc agccataatt gagaggttac     9000

acgggcttga cgccttttct atgcacacat actctcacca cgaactgacg cgggtggctt     9060

cagccctcag aaaacttggg gcgccacccc tcagggtgtg gaagagtcgg gctcgcgcag     9120

tcagggcgtc cctcatctcc cgtggaggga aagcggccgt ttgcggccga tatctcttca     9180

attgggcggt gaagaccaag ctcaaactca ctccattgcc ggaggcgcgc ctactggact     9240

tatccagttg gttcaccgtc ggcgccggcg ggggcggcat ttttcacagc gtgtcgcgcg     9300

cccgaccccg ctcattactc ttcggcctac tcctactttt cgtaggggta ggcctcttcc     9360

tactccccgc tcggtagagc ggcacacact aggtacactc catagctaac tgttcctttt     9420

tttttttttt tttttttttt tttttttttt tttttttttc tttttttttt ttttccctct     9480

ttcttccctt ctcatcttat tctactttct ttcttggtgg ctccatctta gccctagtca     9540

cggctagctg tgaaaggtcc gtgagccgca tgactgcaga gagtgccgta actggtctct     9600

ctgcagatca tgt                                                        9613


<210>  138
<211>  9599
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid

<400>  138
gccagccccc tgatgggggc gacactccac catgaatcac tcccctgtga ggaactactg       60

tcttcacgca gaaagcgtct agccatggcg ttagtatgag tgtcgtgcag cctccaggac      120

cccccctccc gggagagcca tagtggtctg cggaaccggt gagtacaccg gaattgccag      180

gacgaccggg tcctttcttg gatcaacccg ctcaatgcct ggagatttgg gcgtgccccc      240

gcaagactgc tagccgagta gtgttgggtc gcgaaaggcc ttgtggtact gcctgatagg      300

gtgcttgcga gtgccccggg aggtctcgta gaccgtgcac catgagcacg aatcctaaac      360

ctcaaagaaa aaccaaacgt aacaccaacc gtcgcccaca ggacgtcaag ttcccgggtg      420

gcggtcagat cgttggtgga gtttacttgt tgccgcgcag gggccctaga ttgggtgtgc      480

gcgcgacgag gaagacttcc gagcggtcgc aacctcgagg tagacgtcag cctatcccca      540

aggcgcgtcg gcccgagggc aggacctggg ctcagcccgg gtacccttgg cccctctatg      600

gcaatgaggg ttgcgggtgg gcgggatggc tcctgtctcc ccgtggctct cggcctagct      660

ggggccccac ggacccccgg cgtaggtcgc gcaatttggg taaggtcatc gataccctta      720

cgtgcggctt cgccgacctc atggggtaca taccgctcgt cggcgcccct cttggaggcg      780

ctgccagggc cctggcgcat ggcgtccggg ttttggaaga cggcgtgaac tatgcaacag      840

ggaaccttcc tggttgctct ttctctattt tccttctggc cctgctctct tgtctgactg      900

gacccgcttc agcctaccaa gtgcgcaact ccacggggct ttaccatgtc accaatgatt      960

gccccaactc gagcattgtg ttcgaggcgg ctgatgccat cctgcacact ccggggtgtg     1020

tcccttgcgt acgcgagggt aacgcctcga ggtgttgggt ggcggtaacc cccacggtgg     1080

ccaccaggga tggcaaactc cccacaacgc agcttcgacg tcacatcgat ctgcttgtcg     1140

ggagcgccac cctctgctcg gccctttacg tgggggacct gtgcgggtct gtctttcttg     1200

ttggtcaact gttcaccttc tctcccaggc gccactggac gacgcaagat tgcaattgtt     1260

ctatctaccc cggccatatt tcaggtcacc gtatggcatg ggatatgatg atgaactggt     1320

cccctacggc ggcgttgttg gtagctcagc tgctccggat cccacaagcc atcctggaca     1380

tgatcgctgg tgctcactgg ggagtcctgg cgggcatggc gtatttctcc atggtgggga     1440

actgggcgaa ggttctggta gtgctgctgc tatttgccgg cgtcgacgcg gaaacctacg     1500

tcaccggggg aagtgccgcc cgtactacgg ctggacttgc tagtcttttc tcaccaggcg     1560

ccaagcagaa catccagctg gtcaacacca acggcagttg gcacatcaat agcacggcct     1620

tgaactgcaa tgacagcctc aacaccggct ggatagcagg acttttctat caccacaaat     1680

tcaactcttc gggctgttcc gagaggttag ccagctgccg accccttacc gattttgccc     1740

agggctgggg ccctatcagt cacgccgacg gaagtggccc cgaccaacgc ccctactgct     1800

ggcactaccc tccaaaacct tgtggtattg tgcccgcaaa gagcgtgtgt ggcccggtat     1860

attgtttcac tcccagtccc gtggtggtgg gaacgaccga caggtcgggc gcgcctacct     1920

acagctgggg tgcaaatgac acggacgtct tcgtccttaa caacaccagg ccaccgctgg     1980

gcaattggtt cggttgcacc tggatgaact caactggatt caccaaagtg tgcggagcgc     2040

ccccttgcgt catcggaggg gtgggcaaca acaccttgcg ctgccccact gattgtttcc     2100

gcaagcatcc ggaagccaca tactctcggt gcggctccgg tccctggatt acgcccaggt     2160

gcctggtcga ctacccgtat aggctttggc attatccttg taccatcaac tacaccgtgt     2220

ttaaagtcag gatgtacgtg ggaggggtcg agcacaggct ggaagctgcc tgcaactgga     2280

cgcggggcga ccgttgtaat ctggatgaca gggacaggtc cgagctcagc ccgctgctgc     2340

tgtccactac gcagtggcag gtcctcccgt gttccttcac gaccctgcca gccttgtcca     2400

ccggcctcat ccacctccac caaaacatcg tggacgtgca atacttgtac ggggtgggat     2460

caagcatcgc gtcctgggcc atcaagtggg aatacgtcgt tctcttgttc cttctgcttg     2520

cagacgcgcg cgtctgctcc tgcttgtgga tgatgttact catatcccaa gtggaggcgg     2580

ctttggagaa cctcgtagta ctcaatgcag catccctggc cgggacacac ggtcttgtat     2640

ccttcctcgt gttcttctgc tttgcatggt atctgaaggg taagtgggtg cccggagcgg     2700

tctacgccct ctacgggatg tggcctctcc tcttgctcct gttagcgttg ccccagcggg     2760

catacgcact ggacacggag gtggccgcgt cgtgtggcgg cgttgttctt gtcgggttaa     2820

tggcgctgac tctgtcacca tattacaagc gctatatcag ctggtgcttg tggtggcttc     2880

agtatttcct gaccagaata gaagcgcaac tgcacgtgtg gattccccct ctcaacgtcc     2940

ggggggggcg cgatgccgtc atcttactca tgtgtgttgt gcacccggct ctggtatttg     3000

acatcaccaa gctactgctg gctgccttcg ggcccctttg gattcttcaa gccagtttgc     3060

ttaaggtacc ctacttcgtg cgcgttcaag gccttctccg gatctgcgcg ctagcgcgga     3120

agatggctgg aggccattac gtgcaaatgg ccatcatcaa gttaggggcg cttactggca     3180

cttatgttta caaccatctc accccccttc gggactgggc gcacaacggc ctgcgagatc     3240

tggccgtggc tgtggagcca gtcgtcttct cccgaatgga gaccaagctt atcacctggg     3300

gggcagacac cgccgcgtgc ggtgacatca tcaacggctt gcccgtctcc gcccggaggg     3360

gccgggagat actgctcggg ccagccgatg gaatggtctc caaggggtgg agattgctgg     3420

cgcccatcac ggcgtacgcc cagcaaacga ggggcctcct agggtgtata atcaccagtc     3480

tgaccggccg ggacaaaaac caagtggagg gtgagatcca gattgtgtca actgctgccc     3540

aaaccttcct ggcaacgtgc atcaacgggg tttgctggac cgtctaccac ggggccggaa     3600

cgaggaccat cgcatcaccc aagggtccgg ttatccaaat gtataccaat gtggacaaag     3660

accttgtggg ctggcccgct cctcaaggtg cccgctcact gacaccctgt acctgcggct     3720

cctcggacct ttacctggtc acgaggcacg ccgatgtcat tcccgtgcgc cggcggggtg     3780

atagcagggg cagcctgctt tcgccccggc ccatttccta cttgaaaggc tcctcggggg     3840

gtccgctgct gtgccccgcg ggacacgccg taggcttatt cagggccgcg gtgtgcaccc     3900

gtggagtggc taaggcggtg gacttcatcc ctgtggagaa cctagagaca accatgaggt     3960

ccccggtgtt cacggacaac tcctctccac cagcagtgcc ccagagcttc caggtggccc     4020

acctgcatgc tcccaccggc agcggcaaaa gcaccaaggt cccggctgca tacgcagctc     4080

agggctataa ggtgctagtg ctcaacccct ctgtcgctgc aacactgggc tttggtgctt     4140

acatgtccaa ggcccatggg gtcgatccta atatcaggac cggggtgaga acaattacca     4200

ctggcagccc catcacgtac tccacctacg gcaagttcct tgccgacggc gggtgttcag     4260

ggggtgctta tgacataata atttgtgacg agtgccactc cacggatgcc acatccatct     4320

tgggcatcgg caccgttctt gaccaagcag agaccgcggg ggcgagactg gttgtgctcg     4380

ccaccgctac ccctccgggc tccatcaccg tgccccatcc taacatcgag gaggttgctc     4440

tgtccactac cggagagatc cctttttacg gcaaggctat ccccctcgag gcgatcaagg     4500

gggggagaca tctcatcttc tgtcactcaa agaagaagtg cgacgagctc gccgcaaagc     4560

tggtcgcatt gggcatcaat gccgtggcct actaccgcgg tcttgacgtg tctgtcatcc     4620

caaccagcgg cgatgttgtc gtcgtggcga ccgatgctct tatgactggc tataccggcg     4680

actttgactc ggtgatagac tgcaacacgt gtgtcaccca gacagtcgac ctcagccttg     4740

accctacctt caccattgag acgaccacgc tcccccagga cgctgtctcc cgcacacaac     4800

gccggggcag gactggcagg gggaagccag gcatctacag attcgtggca ctgggggagc     4860

gcccctccgg catgttcgac tcgtccgttc tctgtgagtg ctatgacgcg ggctgtgctt     4920

ggtatgagct cacgcccgcc gagactacag ttagactacg agcgtacatg aacaccccgg     4980

ggctccctgt gtgccaggac catcttgaat tttgggaggg cgtctttaca ggcctcaccc     5040

atatagatgc ccatttccta tctcagacaa agcagagcgg ggaaaacttt ccttacctgg     5100

tagcatacca agcaaccgtg tgcgctaggg ctcaagcccc tcccccatcg tgggaccaga     5160

tgtggaagtg tttgactcgc ctcaagccca ccctccatgg gccaacaccc ttgctataca     5220

gactgggcgc tgttcagaat gaagtcaccc tgacgcaccc aatcaccaaa tacatcatga     5280

catgcatgtc ggccgacctg gaggtcgtca cgagcacctg ggtgctcgtc ggcggcgtcc     5340

tggccgcttt ggcctcgtat tgcctgtcaa caggctgcgt ggtcatagtg ggcaggattg     5400

tcctgtctgg gaagccggca attatacctg acagggaagt tctctaccgg gagttcgatg     5460

agatggaaga gtgctctcag cacttaccgt acatcgagca agggatgatg ctcgccgagc     5520

agttcaagca gaaggccctc ggcctcctgc agaccgcgtc ccgtcaggca gaggttgtcg     5580

cccctgctgt ccagaccaac tggcaaaaac tcgaggcctt ctgggcgaag catatgtgga     5640

acttcatcag tgggatacaa tacttggcgg gcttgtcaac gttgcctggt aaccccgcca     5700

ttgcttcatt gatggctttt acagctgctg tcaccagccc actaaccact agccaaaccc     5760

tcctcttcaa catactgggg gggtgggtgg ctgcccagct tgccgccccc ggtgccgcca     5820

ccgcctttgt gggcgctggc ttagccggcg ccgcaatcgg cagtgttgga ctggggaagg     5880

tcctcgtgga cattctagca gggtatggcg cgggcgtggc gggagctctt gtagcattca     5940

agatcatgag cggtgaggtc ccctccacgg aggacctagt caacctgctg cccgccatcc     6000

tctcgcctgg agcccttgta gtcggtgtgg tctgcgcagc aatactgcgc cggcacgtcg     6060

gcccgggcga gggggcagtg caatggatga accggctaat cgccttcgcc tcccggggga     6120

accatgtttc ccccacgcac tatgtgccgg agagcgatgc agctgcccgc gtcactacca     6180

tactcagcag cctcactgta acccagctcc tgaggcgact gcaccagtgg ataagctcgg     6240

agtgtaccac tccatgctcc ggttcctggc tgagggacat ctgggactgg atatgcgagg     6300

tgctgagcga ctttaagacc tggctgaaag ccaagctcat gccgcaactg cctgggattc     6360

cctttgtgtc ctgccagcgt gggtataagg gggtctggcg aggggacggc atcatgcaca     6420

ctcgctgcca ctgtggagct gagataactg gacatgtcaa aaacgggacg atgaggatcg     6480

ttggtcctaa gacttgcagg aacatgtgga gtgggacttt ccccattaac gcctacacca     6540

cgggcccctg tactcccctt cctgcgccga actatacgtt cgcgctgtgg agggtgtctg     6600

cagaggaata cgtggagata aggcaggtgg gggacttcca ctacgtgacg ggtatgacta     6660

ctgacaacct taaatgcccg tgccaggtcc catcgcccga atttttcaca gaattggacg     6720

gggtgcgcct acataggttt gcgccccctt gcaagcccct gctgcgggag gaggtgtcat     6780

tcagagtggg actccacgag tacccggtgg ggtcgcaatt accttgcgag cccgaaccgg     6840

acgtggccgt gttgacgtcc atgctcactg atccctccca tataacagca gaggcggccg     6900

ggagaaggtt ggcgagggga tcacccccct ctatggccag ctcctcggct agccaactgt     6960

ccgctccatc tctcagggca acttgcacta ccaaccatga ctcccctgat gctgagctca     7020

tagaggccaa cctcctatgg aggcaggaga tgggcggcaa catcaccagg gttgagtcag     7080

agaacaaagt ggtgattctg gactccttcg atccgcttgt ggcagaggag gatgagcggg     7140

aggtctccgt gcccgcagag atactgcgga agtctcggaa attcacccca gccctaccca     7200

tttgggcgcg gccggactat aaccccccgc tggtggagcc gtggaaaaag cctgactacg     7260

aaccacctgt ggtccatggc tgcccgcttc cacctccaca gtcccctcct gtgcctccac     7320

ctcggaagaa gcggacggtg atcctcaccg aatcaaccct acctactgcc ttggccgagc     7380

ttgccaccaa aagttttggc agctcctcaa cttccggcat tacgggcgac gacacgacaa     7440

catcccctga gcccgcctcc tctagctgcc ctcccgactc cgacgctgag tcctattctt     7500

ccatgccccc tctggagggg gagcctgggg atccggatct cagcgacggg tcatggtcga     7560

cggtcagtag tgaggccgac aaggaggatg tcgtgtgctg ctcaatgtct tatacctgga     7620

caggcgcact cgtcaccccg tgcgccgcgg aagaacaaaa actgcccatc aacgcactaa     7680

gcaactcgtt gctgcgtcat cacaatctgg tgtattccac cacctcacgc agtgcttgcc     7740

aaaggcagaa gaaagtcaca tttgacagac tgcaagtcct ggacagccat taccaggacg     7800

tgctcaagga ggttaaggca gcggcgtcaa aagtgaaggc taacttgcta tccgtagagg     7860

aagcttgcag cctgacgccc ccacactcag ccaaatccaa gtttggctat ggggcaaaag     7920

acgtccgttg ccatgccaga aaggccgtaa accacatcaa ctccgtgtgg aaagaccttc     7980

tggaagacag tgtaacacca atagacacta ccatcatggc taagaacgag gttttctgcg     8040

ttcagcctga gaaggggggt cgtaagccag ctcgtctcat cgtgttcccc gacctgggtg     8100

tacgcgtgtg cgagaagatg gccttgtacg acgtagtcag caagctcccc ctagccgtga     8160

tgggaagctc ctacggattc caatactcac caggacagcg ggttgaattc ctcgtgcaag     8220

cgtggaagtc caagaagacc ccaatggggt tttcgtatga tacccgctgt tttgactcca     8280

cagtcactga gaatgatatc cgtacggagg aggcaatcta ccaatgttgt gacctggacc     8340

cccaagcccg cgtggccatc aagtccctca ctgagaggct ttatgtcggg ggccctctta     8400

ccaattcaag gggggagaac tgcggctatc gcaggtgccg cgcgagcggc gtactgacga     8460

ccagctgtgg taacaccctc acctgctaca tcaaggcccg agcagcctgt cgagccgcag     8520

ggctccagga ctgcaccatg ctcgtgtgtg gcgacgactt agtcgttatc tgtgagagtg     8580

cgggggtcca ggaggacgcg gcgagcctga gagccttcac ggaggctatg accaggtact     8640

ccgccccccc cggggacccc ccacaaccag aatacgactt ggagctcata acatcatgct     8700

cctccaacgt gtcagtcgcc cacgacggcg ctggaaaaag ggtctactac ctcacccgtg     8760

accctacaac ccccctcgcg cgggccgcgt gggagacagc aagacacact ccagtcaatt     8820

cctggctagg caacataatt atgtttgccc ccacactgtg ggcgaggatg atactgatga     8880

cccatttctt tagcgtcctc atagccaggg atcagcttga acaggccctc gattgcgaga     8940

tctacggggc ctgctactcc atagaaccac tggatctacc tccaatcatt caaagactcc     9000

atggcctcag cgcattttca ctccacagtt actctccagg tgaaatcaat agggtggccg     9060

catgcctcag aaaacttggg gtcccgccct tgcgagcttg gagacaccgg gcccggaatg     9120

tccgcgctag gcttctgtcc agaggaggca gggctgccat ttgtggcaag tacctcttca     9180

actgggcagt aaggacaaag ctcaaactca ctccaatagc ggccgctggc cggctagact     9240

tatctggctg gttcacggct ggctacagcg ggggaggcat ttttcacagc gtgtctcatg     9300

cccggccccg ctggttctgg ttttgcctac tcctgctcgc tgcaggggta ggcatctacc     9360

tcctccccaa ccgatgaagg ttggggtaaa cactccggcc tcttaggcca tttcctgttt     9420

tttttttttt tttttttttt tttttttttt tttttttttt tttctttttc cctctttttc     9480

ttctcttttt ccttctttaa tggtggctcc atcttagccc tagtcacggc tagctgtgaa     9540

aggtccgtga gccgcatgac tgcagagagt gctgatactg gcctctctgc agatcatgt      9599


<210>  139
<211>  9599
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid

<400>  139
gccagccccc tgatgggggc gacactccac catgaatcac tcccctgtga ggaactactg       60

tcttcacgca gaaagcgtct agccatggcg ttagtatgag tgtcgtgcag cctccaggac      120

cccccctccc gggagagcca tagtggtctg cggaaccggt gagtacaccg gaattgccag      180

gacgaccggg tcctttcttg gatcaacccg ctcaatgcct ggagatttgg gcgtgccccc      240

gcaagactgc tagccgagta gtgttgggtc gcgaaaggcc ttgtggtact gcctgatagg      300

gtgcttgcga gtgccccggg aggtctcgta gaccgtgcac catgagcacg aatcctaaac      360

ctcaaagaaa aaccaaacgt aacaccaacc gtcgcccaca ggacgtcaag ttcccgggtg      420

gcggtcagat cgttggtgga gtttacttgt tgccgcgcag gggccctaga ttgggtgtgc      480

gcgcgacgag gaagacttcc gagcggtcgc aacctcgagg tagacgtcag cctatcccca      540

aggcgcgtcg gcccgagggc aggacctggg ctcagcccgg gtacccttgg cccctctatg      600

gcaatgaggg ttgcgggtgg gcgggatggc tcctgtctcc ccgtggctct cggcctagct      660

ggggccccac ggacccccgg cgtaggtcgc gcaatttggg taaggtcatc gataccctta      720

cgtgcggctt cgccgacctc atggggtaca taccgctcgt cggcgcccct cttggaggcg      780

ctgccagggc cctggcgcat ggcgtccggg ttttggaaga cggcgtgaac tatgcaacag      840

ggaaccttcc tggttgctct ttctctattt tccttctggc cctgctctct tgtctgactg      900

gacccgcttc agcctaccaa gtgcgcaact ccacggggct ttaccatgtc accaatgatt      960

gccccaactc gagcattgtg ttcgaggcgg ctgatgccat cctgcacact ccggggtgtg     1020

tcccttgcgt acgcgagggt aacgcctcga ggtgttgggt ggcggtaacc cccacggtgg     1080

ccaccaggga tggcaaactc cccacaacgc agcttcgacg tcacatcgat ctgcttgtcg     1140

ggagcgccac cctctgctcg gccctttacg tgggggacct gtgcgggtct gtctttcttg     1200

ttggtcaact gttcaccttc tctcccaggc gccactggac gacgcaagat tgcaattgtt     1260

ctatctaccc cggccatatt tcaggtcacc gtatggcatg ggatatgatg atgaactggt     1320

cccctacggc ggcgttgttg gtagctcagc tgctccggat cccacaagcc atcctggaca     1380

tgatcgctgg tgctcactgg ggagtcctgg cgggcatggc gtatttctcc atggtgggga     1440

actgggcgaa ggttctggta gtgctgctgc tatttgccgg cgtcgacgcg gaaacctacg     1500

tcaccggggg aagtgccgcc cgtactacgg ctggacttgc tagtcttttc tcaccaggcg     1560

ccaagcagaa catccagctg gtcaacacca acggcagttg gcacatcaat agcacggcct     1620

tgaactgcaa tgacagcctc aacaccggct ggatagcagg acttttctat caccacaaat     1680

tcaactcttc gggctgttcc gagaggttag ccagctgccg accccttacc gattttgccc     1740

agggctgggg ccctatcagt cacgccgacg gaagtggccc cgaccaacgc ccctactgct     1800

ggcactaccc tccaaaacct tgtggtattg tgcccgcaaa gagcgtgtgt ggcccggtat     1860

attgtttcac tcccagtccc gtggtggtgg gaacgaccga caggtcgggc gcgcctacct     1920

acagctgggg tgcaaatgac acggacgtct tcgtccttaa caacaccagg ccaccgctgg     1980

gcaattggtt cggttgcacc tggatgaact caactggatt caccaaagtg tgcggagcgc     2040

ccccttgcgt catcggaggg gtgggcaaca acaccttgcg ctgccccact gattgtttcc     2100

gcaagcatcc ggaagccaca tactctcggt gcggctccgg tccctggatt acgcccaggt     2160

gcctggtcga ctacccgtat aggctttggc attatccttg taccatcaac tacaccgtgt     2220

ttaaagtcag gatgtacgtg ggaggggtcg agcacaggct ggaagctgcc tgcaactgga     2280

cgcggggcga ccgttgtaat ctggatgaca gggacaggtc cgagctcagc ccgctgctgc     2340

tgtccactac gcagtggcag gtcctcccgt gttccttcac gaccctgcca gccttgtcca     2400

ccggcctcat ccacctccac caaaacatcg tggacgtgca atacttgtac ggggtgggat     2460

caagcatcgc gtcctgggcc atcaagtggg aatacgtcgt tctcttgttc cttctgcttg     2520

cagacgcgcg cgtctgctcc tgcttgtgga tgatgttact catatcccaa gtggaggcgg     2580

ctttggagaa cctcgtagta ctcaatgcag catccctggc cgggacacac ggtcttgtat     2640

ccttcctcgt gttcttctgc tttgcatggt atctgaaggg taagtgggtg cccggagcgg     2700

tctacgccct ctacgggatg tggcctctcc tcttgctcct gttagcgttg ccccagcggg     2760

catacgcact ggacacggag gtggccgcgt cgtgtggcgg cgttgttctt gtcgggttaa     2820

tggcgctgac tctgtcacca tattacaagc gctatatcag ctggtgcttg tggtggcttc     2880

agtatttcct gaccagaata gaagcgcaac tgcacgtgtg gattccccct ctcaacgtcc     2940

ggggggggcg cgatgccgtc atcttactca tgtgtgttgt gcacccggct ctggtatttg     3000

acatcaccaa gctactgctg gctgccttcg ggcccctttg gattcttcaa gccagtttgc     3060

ttaaggtacc ctacttcgtg cgcgttcaag gccttctccg gatctgcgcg ctagcgcgga     3120

agatggctgg aggccattac gtgcaaatgg ccatcatcaa gttaggggcg cttactggca     3180

cttatgttta caaccatctc accccccttc gggactgggc gcacaacggc ctgcgagatc     3240

tggccgtggc tgtggagcca gtcgtcttct cccgaatgga gaccaagctt atcacctggg     3300

gggcagacac cgccgcgtgc ggtgacatca tcaacggctt gcccgtctcc gcccggaggg     3360

gccgggagat actgctcggg ccagccgatg gaatggtctc caaggggtgg agattgctgg     3420

cgcccatcac ggcgtacgcc cagcaaacga ggggcctcct agggtgtata atcaccagtc     3480

tgaccggccg ggacaaaaac caagtggagg gtgagatcca gattgtgtca actgctgccc     3540

aaaccttcct ggcaacgtgc atcaacgggg tttgctggac cgtctaccac ggggccggaa     3600

cgaggaccat cgcatcaccc aagggtccgg ttatccaaat gtataccaat gtggacaaag     3660

accttgtggg ctggcccgct cctcaaggtg cccgctcact gacaccctgt acctgcggct     3720

cctcggacct ttacctggtc acgaggcacg ccgatgtcat tcccgtgcgc cggcggggtg     3780

atagcagggg cagcctgctt tcgccccggc ccatttccta cttgaaaggc tcctcggggg     3840

gtccgctgct gtgccccgcg ggacacgccg taggcttatt cagggccgcg gtgtgcaccc     3900

gtggagtggc taaggcggtg gacttcatcc ctgtggagaa cctagagaca accatgaggt     3960

ccccggtgtt cacggacaac tcctctccac cagcagtgcc ccagagcttc caggtgggcc     4020

acctgcatgc tcccaccggc agcggcaaaa gcaccaaggt cccggctgca tacgcagctc     4080

agggctataa ggtgctagtg ctcaacccct ctgtcgctgc aacactgggc tttggtgctt     4140

acatgtccaa ggcccatggg gtcgatccta atatcaggac cggggtgaga acaattacca     4200

ctggcagccc catcacgtac tccacctacg gcaagttcct tgccgacggc gggtgttcag     4260

ggggtgctta tgacataata atttgtgacg agtgccactc cacggatgcc acatccatct     4320

tgggcatcgg caccgttctt gaccaagcag agaccgcggg ggcgagactg gttgtgctcg     4380

ccaccgctac ccctccgggc tccatcaccg tgccccatcc taacatcgag gaggttgctc     4440

tgtccactac cggagagatc cctttttacg gcaaggctat ccccctcgag gcgatcaagg     4500

gggggagaca tctcatcttc tgtcactcaa agaagaagtg cgacgagctc gccgcaaagc     4560

tggtcgcatt gggcatcaat gccgtggcct actaccgcgg tcttgacgtg tctgtcatcc     4620

caaccagcgg cgatgttgtc gtcgtggcga ccgatgctct tatgactggc tataccggcg     4680

actttgactc ggtgatagac tgcaacacgt gtgtcaccca gacagtcgac ctcagccttg     4740

accctacctt caccattgag acgaccacgc tcccccagga cgctgtctcc cgcacacaac     4800

gccggggcag gactggcagg gggaagccag gcatctacag attcgtggca ctgggggagc     4860

gcccctccgg catgttcgac tcgtccgttc tctgtgagtg ctatgacgcg ggctgtgctt     4920

ggtatgagct cacgcccgcc gagactacag ttagactacg agcgtacatg aacaccccgg     4980

ggctccctgt gtgccaggac catcttgaat tttgggaggg cgtctttaca ggcctcaccc     5040

atatagatgc ccatttccta tctcagacaa agcagagcgg ggaaaacttt ccttacctgg     5100

tagcatacca agcaaccgtg tgcgctaggg ctcaagcccc tcccccatcg tgggaccaga     5160

tgtggaagtg tttgactcgc ctcaagccca ccctccatgg gccaacaccc ttgctataca     5220

gactgggcgc tgttcagaat gaagtcaccc tgacgcaccc aatcaccaaa tacatcatga     5280

catgcatgtc ggccgacctg gaggtcgtca cgagcacctg ggtgctcgtc ggcggcgtcc     5340

tggccgcttt ggcctcgtat tgcctgtcaa caggctgcgt ggtcatagtg ggcaggattg     5400

tcctgtctgg gaagccggca attatacctg acagggaagt tctctaccgg gagttcgatg     5460

agatggaaga gtgctctcag cacttaccgt acatcgagca agggatgatg ctcgccgagc     5520

agttcaagca gaaggccctc ggcctcctgc agaccgcgtc ccgtcaggca gaggttgtcg     5580

cccctgctgt ccagaccaac tggcaaaaac tcgaggcctt ctgggcgaag catatgtgga     5640

acttcatcag tgggatacac tacttggcgg gcttgtcaac gttgcctggt aaccccgcca     5700

ttgcttcatt gatggctttt acagctgctg tcaccagccc actaaccact agccaaaccc     5760

tcctcttcaa catactgggg gggtgggtgg ctgcccagct tgccgccccc ggtgccgcca     5820

ccgcctttgt gggcgctggc ttagccggcg ccgcaatcgg cagtgttgga ctggggaagg     5880

tcctcgtgga cattctagca gggtatggcg cgggcgtggc gggagctctt gtagcattca     5940

agatcatgag cggtgaggtc ccctccacgg aggacctagt caacctgctg cccgccatcc     6000

tctcgcctgg agcccttgta gtcggtgtgg tctgcgcagc aatactgcgc cggcacgtcg     6060

gcccgggcga gggggcagtg caatggatga accggctaat cgccttcgcc tcccggggga     6120

accatgtttc ccccacgcac tatgtgccgg agagcgatgc agctgcccgc gtcactacca     6180

tactcagcag cctcactgta acccagctcc tgaggcgact gcaccagtgg ataagctcgg     6240

agtgtaccac tccatgctcc ggttcctggc tgagggacat ctgggactgg atatgcgagg     6300

tgctgagcga ctttaagacc tggctgaaag ccaagctcat gccgcaactg cctgggattc     6360

cctttgtgtc ctgccagcgt gggtataagg gggtctggcg aggggacggc atcatgcaca     6420

ctcgctgcca ctgtggagct gagataactg gacatgtcaa aaacgggacg atgaggatcg     6480

ttggtcctaa gacttgcagg aacatgtgga gtgggacttt ccccattaac gcctacacca     6540

cgggcccctg tactcccctt cctgcgccga actatacgtt cgcgctgtgg agggtgtctg     6600

cagaggaata cgtggagata aggcaggtgg gggacttcca ctacgtgacg ggtatgacta     6660

ctgacaacct taaatgcccg tgccaggtcc catcgcccga atttttcaca gaattggacg     6720

gggtgcgcct acataggttt gcgccccctt gcaagcccct gctgcgggag gaggtgtcat     6780

tcagagtggg actccacgag tacccggtgg ggtcgcaatt accttgcgag cccgaaccgg     6840

acgtggccgt gttgacgtcc atgctcactg atccctccca tataacagca gaggcggccg     6900

ggagaaggtt ggcgagggga tcacccccct ctatggccag ctcctcggct agccaactgt     6960

ccgctccatc tctcagggca acttgcacta ccaaccatga ctcccctgat gctgagctca     7020

tagaggccaa cctcctatgg aggcaggaga tgggcggcaa catcaccagg gttgagtcag     7080

agaacaaagt ggtgattctg gactccttcg atccgcttgt ggcagaggag gatgagcggg     7140

aggtctccgt gcccgcagag atactgcgga agtctcggaa attcacccca gccctaccca     7200

tttgggcgcg gccggactat aaccccccgc tggtggagcc gtggaaaaag cctgactacg     7260

aaccacctgt ggtccatggc tgcccgcttc cacctccaca gtcccctcct gtgcctccac     7320

ctcggaagaa gcggacggtg atcctcaccg aatcaaccct acctactgcc ttggccgagc     7380

ttgccaccaa aagttttggc agctcctcaa cttccggcat tacgggcgac gacacgacaa     7440

catcccctga gcccgcctcc tctagctgcc ctcccgactc cgacgctgag tcctattctt     7500

ccatgccccc tctggagggg gagcctgggg atccggatct cagcgacggg tcatggtcga     7560

cggtcagtag tgaggccgac aaggaggatg tcgtgtgctg ctcaatgtct tatacctgga     7620

caggcgcact cgtcaccccg tgcgccgcgg aagaacaaaa actgcccatc aacgcactaa     7680

gcaactcgtt gctgcgtcat cacaatctgg tgtattccac cacctcacgc agtgcttgcc     7740

aaaggcagaa gaaagtcaca tttgacagac tgcaagtcct ggacagccat taccaggacg     7800

tgctcaagga ggttaaggca gcggcgtcaa aagtgaaggc taacttgcta tccgtagagg     7860

aagcttgcag cctgacgccc ccacactcag ccaaatccaa gtttggctat ggggcaaaag     7920

acgtccgttg ccatgccaga aaggccgtaa accacatcaa ctccgtgtgg aaagaccttc     7980

tggaagacag tgtaacacca atagacacta ccatcatggc taagaacgag gttttctgcg     8040

ttcagcctga gaaggggggt cgtaagccag ctcgtctcat cgtgttcccc gacctgggtg     8100

tacgcgtgtg cgagaagatg gccttgtacg acgtagtcag caagctcccc ctagccgtga     8160

tgggaagctc ctacggattc caatactcac caggacagcg ggttgaattc ctcgtgcaag     8220

cgtggaagtc caagaagacc ccaatggggt tttcgtatga tacccgctgt tttgactcca     8280

cagtcactga gaatgatatc cgtacggagg aggcaatcta ccaatgttgt gacctggacc     8340

cccaagcccg cgtggccatc aagtccctca ctgagaggct ttatgtcggg ggccctctta     8400

ccaattcaag gggggagaac tgcggctatc gcaggtgccg cgcgagcggc gtactgacga     8460

ccagctgtgg taacaccctc acctgctaca tcaaggcccg agcagcctgt cgagccgcag     8520

ggctccagga ctgcaccatg ctcgtgtgtg gcgacgactt agtcgttatc tgtgagagtg     8580

cgggggtcca ggaggacgcg gcgagcctga gagccttcac ggaggctatg accaggtact     8640

ccgccccccc cggggacccc ccacaaccag aatacgactt ggagctcata acatcatgct     8700

cctccaacgt gtcagtcgcc cacgacggcg ctggaaaaag ggtctactac ctcacccgtg     8760

accctacaac ccccctcgcg cgggccgcgt gggagacagc aagacacact ccagtcaatt     8820

cctggctagg caacataatt atgtttgccc ccacactgtg ggcgaggatg atactgatga     8880

cccatttctt tagcgtcctc atagccaggg atcagcttga acaggccctc gattgcgaga     8940

tctacggggc ctgctactcc atagaaccac tggatctacc tccaatcatt caaagactcc     9000

atggcctcag cgcattttca ctccacagtt actctccagg tgaaatcaat agggtggccg     9060

catgcctcag aaaacttggg gtcccgccct tgcgagcttg gagacaccgg gcccggaatg     9120

tccgcgctag gcttctgtcc agaggaggca gggctgccat ttgtggcaag tacctcttca     9180

actgggcagt aaggacaaag ctcaaactca ctccaatagc ggccgctggc cggctagact     9240

tatctggctg gttcacggct ggctacagcg ggggaggcat ttttcacagc gtgtctcatg     9300

cccggccccg ctggttctgg ttttgcctac tcctgctcgc tgcaggggta ggcatctacc     9360

tcctccccaa ccgatgaagg ttggggtaaa cactccggcc tcttaggcca tttcctgttt     9420

tttttttttt tttttttttt tttttttttt tttttttttt tttctttttc cctctttttc     9480

ttctcttttt ccttctttaa tggtggctcc atcttagccc tagtcacggc tagctgtgaa     9540

aggtccgtga gccgcatgac tgcagagagt gctgatactg gcctctctgc agatcatgt      9599


<210>  140
<211>  9599
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid

<400>  140
gccagccccc tgatgggggc gacactccac catgaatcac tcccctgtga ggaactactg       60

tcttcacgca gaaagcgtct agccatggcg ttagtatgag tgtcgtgcag cctccaggac      120

cccccctccc gggagagcca tagtggtctg cggaaccggt gagtacaccg gaattgccag      180

gacgaccggg tcctttcttg gatcaacccg ctcaatgcct ggagatttgg gcgtgccccc      240

gcaagactgc tagccgagta gtgttgggtc gcgaaaggcc ttgtggtact gcctgatagg      300

gtgcttgcga gtgccccggg aggtctcgta gaccgtgcac catgagcacg aatcctaaac      360

ctcaaagaaa aaccaaacgt aacaccaacc gtcgcccaca ggacgtcaag ttcccgggtg      420

gcggtcagat cgttggtgga gtttacttgt tgccgcgcag gggccctaga ttgggtgtgc      480

gcgcgacgag gaagacttcc gagcggtcgc aacctcgagg tagacgtcag cctatcccca      540

aggcgcgtcg gcccgagggc aggacctggg ctcagcccgg gtacccttgg cccctctatg      600

gcaatgaggg ttgcgggtgg gcgggatggc tcctgtctcc ccgtggctct cggcctagct      660

ggggccccac ggacccccgg cgtaggtcgc gcaatttggg taaggtcatc gataccctta      720

cgtgcggctt cgccgacctc atggggtaca taccgctcgt cggcgcccct cttggaggcg      780

ctgccagggc cctggcgcat ggcgtccggg ttttggaaga cggcgtgaac tatgcaacag      840

ggaaccttcc tggttgctct ttctctattt tccttctggc cctgctctct tgtctgactg      900

gacccgcttc agcctaccaa gtgcgcaact ccacggggct ttaccatgtc accaatgatt      960

gccccaactc gagcattgtg ttcgaggcgg ctgatgccat cctgcacact ccggggtgtg     1020

tcccttgcgt acgcgagggt aacgcctcga ggtgttgggt ggcggtaacc cccacggtgg     1080

ccaccaggga tggcaaactc cccacaacgc agcttcgacg tcacatcgat ctgcttgtcg     1140

ggagcgccac cctctgctcg gccctttacg tgggggacct gtgcgggtct gtctttcttg     1200

ttggtcaact gttcaccttc tctcccaggc gccactggac gacgcaagat tgcaattgtt     1260

ctatctaccc cggccatatt tcaggtcacc gtatggcatg ggatatgatg atgaactggt     1320

cccctacggc ggcgttgttg gtagctcagc tgctccggat cccacaagcc atcctggaca     1380

tgatcgctgg tgctcactgg ggagtcctgg cgggcatggc gtatttctcc atggtgggga     1440

actgggcgaa ggttctggta gtgctgctgc tatttgccgg cgtcgacgcg gaaacctacg     1500

tcaccggggg aagtgccgcc cgtactacgg ctggacttgc tagtcttttc tcaccaggcg     1560

ccaagcagaa catccagctg gtcaacacca acggcagttg gcacatcaat agcacggcct     1620

tgaactgcaa tgacagcctc aacaccggct ggatagcagg acttttctat caccacaaat     1680

tcaactcttc gggctgttcc gagaggttag ccagctgccg accccttacc gattttgccc     1740

agggctgggg ccctatcagt cacgccgacg gaagtggccc cgaccaacgc ccctactgct     1800

ggcactaccc tccaaaacct tgtggtattg tgcccgcaaa gagcgtgtgt ggcccggtat     1860

attgtttcac tcccagtccc gtggtggtgg gaacgaccga caggtcgggc gcgcctacct     1920

acagctgggg tgcaaatgac acggacgtct tcgtccttaa caacaccagg ccaccgctgg     1980

gcaattggtt cggttgcacc tggatgaact caactggatt caccaaagtg tgcggagcgc     2040

ccccttgcgt catcggaggg gtgggcaaca acaccttgcg ctgccccact gattgtttcc     2100

gcaagcatcc ggaagccaca tactctcggt gcggctccgg tccctggatt acgcccaggt     2160

gcctggtcga ctacccgtat aggctttggc attatccttg taccatcaac tacaccgtgt     2220

ttaaagtcag gatgtacgtg ggaggggtcg agcacaggct ggaagctgcc tgcaactgga     2280

cgcggggcga ccgttgtaat ctggatgaca gggacaggtc cgagctcagc ccgctgctgc     2340

tgtccactac gcagtggcag gtcctcccgt gttccttcac gaccctgcca gccttgtcca     2400

ccggcctcat ccacctccac caaaacatcg tggacgtgca atacttgtac ggggtgggat     2460

caagcatcgc gtcctgggcc atcaagtggg aatacgtcgt tctcttgttc cttctgcttg     2520

cagacgcgcg cgtctgctcc tgcttgtgga tgatgttact catatcccaa gtggaggcgg     2580

ctttggagaa cctcgtagta ctcaatgcag catccctggc cgggacacac ggtcttgtat     2640

ccttcctcgt gttcttctgc tttgcatggt atctgaaggg taagtgggtg cccggagcgg     2700

tctacgccct ctacgggatg tggcctctcc tcttgctcct gttagcgttg ccccagcggg     2760

catacgcact ggacacggag gtggccgcgt cgtgtggcgg cgttgttctt gtcgggttaa     2820

tggcgctgac tctgtcacca tattacaagc gctatatcag ctggtgcttg tggtggcttc     2880

agtatttcct gaccagaata gaagcgcaac tgcacgtgtg gattccccct ctcaacgtcc     2940

ggggggggcg cgatgccgtc atcttactca tgtgtgttgt gcacccggct ctggtatttg     3000

acatcaccaa gctactgctg gctgccttcg ggcccctttg gattcttcaa gccagtttgc     3060

ttaaggtacc ctacttcgtg cgcgttcaag gccttctccg gatctgcgcg ctagcgcgga     3120

agatggctgg aggccattac gtgcaaatgg ccatcatcaa gttaggggcg cttactggca     3180

cttatgttta caaccatctc accccccttc gggactgggc gcacaacggc ctgcgagatc     3240

tggccgtggc tgtggagcca gtcgtcttct cccgaatgga gaccaagctt atcacctggg     3300

gggcagacac cgccgcgtgc ggtgacatca tcaacggctt gcccgtctcc gcccggaggg     3360

gccgggagat actgctcggg ccagccgatg gaatggtctc caaggggtgg agattgctgg     3420

cgcccatcac ggcgtacgcc cagcaaacga ggggcctcct agggtgtata atcaccagtc     3480

tgaccggccg ggacaaaaac caagtggagg gtgagatcca gattgtgtca actgctgccc     3540

aaaccttcct ggcaacgtgc atcaacgggg tttgctggac cgtctaccac ggggccggaa     3600

cgaggaccat cgcatcaccc aagggtccgg ttatccaaat gtataccaat gtggacaaag     3660

accttgtggg ctggcccgct cctcaaggtg cccgctcact gacaccctgt acctgcggct     3720

cctcggacct ttacctggtc acgaggcacg ccgatgtcat tcccgtgcgc cggcggggtg     3780

atagcagggg cagcctgctt tcgccccggc ccatttccta cttgaaaggc tcctcggggg     3840

gtccgctgct gtgccccgcg ggacacgccg taggcttatt cagggccgcg gtgtgcaccc     3900

gtggagtggc taaggcggtg gacttcatcc ctgtggagaa cctagagaca accatgaggt     3960

ccccggtgtt cacggacaac tcctctccac cagcagtgcc ccagagcttc caggtgggcc     4020

acctgcatgc tcccaccggc agcggcaaaa gcaccaaggt cccggctgca tacgcagctc     4080

agggctataa ggtgctagtg ctcaacccct ctgtcgctgc aacactgggc tttggtgctt     4140

acatgtccaa ggcccatggg gtcgatccta atatcaggac cggggtgaga acaattacca     4200

ctggcagccc catcacgtac tccacctacg gcaagttcct tgccgacggc gggtgttcag     4260

ggggtgctta tgacataata atttgtgacg agtgccactc cacggatgcc acatccatct     4320

tgggcatcgg caccgttctt gaccaagcag agaccgcggg ggcgagactg gttgtgctcg     4380

ccaccgctac ccctccgggc tccatcaccg tgccccatcc taacatcgag gaggttgctc     4440

tgtccactac cggagagatc cctttttacg gcaaggctat ccccctcgag gcgatcaagg     4500

gggggagaca tctcatcttc tgtcactcaa agaagaagtg cgacgagctc gccgcaaagc     4560

tggtcgcatt gggcatcaat gccgtggcct actaccgcgg tcttgacgtg tctgtcatcc     4620

caaccagcgg cgatgttgtc gtcgtggcga ccgatgctct tatgactggc tataccggcg     4680

actttgactc ggtgatagac tgcaacacgt gtgtcaccca gacagtcgac ctcagccttg     4740

accctacctt caccattgag acgaccacgc tcccccagga cgctgtctcc cgcacacaac     4800

gccggggcag gactggcagg gggaagccag gcatctacag attcgtggca ctgggggagc     4860

gcccctccgg catgttcgac tcgtccgttc tctgtgagtg ctatgacgcg ggctgtgctt     4920

ggtatgagct cacgcccgcc gagactacag ttagactacg agcgtacatg aacaccccgg     4980

ggctccctgt gtgccaggac catcttgaat tttgggaggg cgtctttaca ggcctcaccc     5040

atatagatgc ccatttccta tctcagacaa agcagagcgg ggaaaacttt ccttacctgg     5100

tagcatacca agcaaccgtg tgcgctaggg ctcaagcccc tcccccatcg tgggaccaga     5160

tgtggaagtg tttgactcgc ctcaagccca ccctccatgg gccaacaccc ttgctataca     5220

gactgggcgc tgttcagaat gaagtcaccc tgacgcaccc aatcaccaaa tacatcatga     5280

catgcatgtc ggccgacctg gaggtcgtca cgagcacctg ggtgctcgtc ggcggcgtcc     5340

tggccgcttt ggcctcgtat tgcctgtcaa caggctgcgt ggtcatagtg ggcaggattg     5400

tcctgtctgg gaagccggca attatacctg acagggaagt tctctaccgg gagttcgatg     5460

agatggaaga gtgctctcag cacttaccgt acatcgagca agggatgatg ctcgccgagc     5520

agttcaagca gaaggccctc ggcctcctgc agaccgcgtc ccgtcaggca gaggttgtcg     5580

cccctgctgt ccagaccaac tggcaaaaac tcgaggcctt ctgggcgaag catatgtgga     5640

acttcatcag tgggatacaa tacttggcgg gcttgtcaac gttgcctggt aaccccgcca     5700

ttgcttcatt gatggctttt acagctgctg tcaccagccc actaaccact agccaaaccc     5760

tcctcttcaa catactgggg gggtgggtgg ctgcccagct tgccgccccc ggtgccgcca     5820

ccgcctttgt gggcgctggc ttagccggcg ccgcaatcgg cagtgttgga ctggggaagg     5880

tcctcgtgga cattctagca gggtatggcg cgggcgtggc gggagctctt gtagcattca     5940

agatcatgag cggtgaggtc ccctccacgg aggacctagt caacctgctg cccgccatcc     6000

tctcgcctgg agcccttgta gtcggtgtgg tctgcgcagc aatactgcgc cggcacgtcg     6060

gcccgggcga gggggcagtg caatggatga accggctaat cgccttcgcc tcccggggga     6120

accatgtttc ccccacgcac tatgtgccgg agagcgatgc agctgcccgc gtcactacca     6180

tactcagcag cctcactgta acccagctcc tgaggcgact gcaccagtgg ataagctcgg     6240

agtgtaccac tccatgctcc ggttcctggc tgagggacat ctgggactgg atatgcgagg     6300

tgctgagcga ctttaagacc tggctgaaag ccaagctcat gccgcaactg cctgggattc     6360

cctttgtgtc ctgccagcgt gggtataagg gggtctggcg aggggacggc atcatgcaca     6420

ctcgctgcca ctgtggagct gagataactg gacatgtcaa aaacgggacg atgaggatcg     6480

ttggtcctaa gacttgcagg aacatgtgga gtgggacttt ccccattaac gcctacacca     6540

cgggcccctg tactcccctt cctgcgccga actatacgtt cgcgctgtgg agggtgtctg     6600

cagaggaata cgtggagata aggcaggtgg gggacttcca ctacgtgacg ggtatgacta     6660

ctgacaacct taaatgcccg tgccaggtcc catcgcccga atttttcaca gaattggacg     6720

gggtgcgcct acataggttt gcgccccctt gcaagcccct gctgcgggag gaggtgtcat     6780

tcagagtggg actccacgag tacccggtgg ggtcgcaatt accttgcgag cccgaaccgg     6840

acgtggccgt gttgacgtcc atgctcactg atccctccca tataacagca gaggcggccg     6900

ggagaaggtt ggcgagggga tcacccccct ctatggccag ctcctcggct agccaactgt     6960

ccgctccatc tctcagggca acttgcacta ccaaccatga ctcccctgat gctgagctca     7020

tagaggccaa cctcctatgg aggcaggaga tgggcggcaa catcaccagg gttgagtcag     7080

agaacaaagt ggtgattctg gactccttcg atccgcttgt ggcagaggag gatgagcggg     7140

aggtctccgt gcccgcagag atactgcgga agtctcggaa attcacccca gccctaccca     7200

tttgggcgcg gccggactat aaccccccgc tggtggagcc gtggaaaaag cctgactacg     7260

aaccacctgt ggtccatggc tgcccgcttc cacctccaca gtcccctcct gtgcctccac     7320

ctcggaagaa gcggacggtg atcctcaccg aatcaaccct acctactgcc ttggccgagc     7380

ttgccaccaa aagttttggc agctcctcaa cttccggcat tacgggcgac gacacgacaa     7440

catcccctga gcccgcctcc tctagctgcc ctcccgactc cgacgctgag tcctattctt     7500

ccatgccccc tctggagggg gagcctgggg atccggatct cagcgacggg tcatggtcga     7560

cggtcagtag tgaggccgac aaggaggatg tcgtgtgctg ctcaatgtct tatacctgga     7620

caggcgcact cgtcaccccg tgcgccgcgg aagaacaaaa actgcccatc aacgcactaa     7680

gcaactcgtt gctgcgtcat cacaatctgg tgtattccac cacctcacgc agtgcttgcc     7740

aaaggcagaa gaaagtcaca tttgacagac tgcaagtcct ggacagccat taccaggacg     7800

tgctcaagga ggttaaggca gcggcgtcaa aagtgaaggc taacttgcta tccgtagagg     7860

aagcttgcag cctgacgccc ccacactcag ccaaatccaa gtttggctat ggggcaaaag     7920

acgtccgttg ccatgccaga aaggccgtaa accacatcaa ctccgtgtgg aaagaccttc     7980

tggaagacag tgtaacacca atagacacta ccatcatggc taagaacgag gttttctgcg     8040

ttcagcctga gaaggggggt cgtaagccag ctcgtctcat cgtgttcccc gacctgggtg     8100

tacgcgtgtg cgagaagatg gccttgtacg acgtagtcag caagctcccc ctagccgtga     8160

tgggaagctc ctacggattc caatactcac caggacagcg ggttgaattc ctcgtgcaag     8220

cgtggaagtc caagaagacc ccaatggggt tttcgtatga tacccgctgt tttgactcca     8280

cagtcactga gaatgatatc cgtacggagg aggcaatcta ccaatgttgt gacctggacc     8340

cccaagcccg cgtggccatc aagtccctca ctgagaggct ttatgtcggg ggccctctta     8400

ccaattcaag gggggagaac tgcggctatc gcaggtgccg cgcgagcggc gtactgacga     8460

ccagctgtgg taacaccctc acctgctaca tcaaggcccg agcagcctgt cgagccgcag     8520

ggctccagga ctgcaccatg ctcgtgtgtg gcgacgactt agtcgttatc tgtgagagtg     8580

cgggggtcca ggaggacgcg gcgagcctga gagccttcac ggaggctatg accaggtact     8640

ccgccccccc cggggacccc ccacaaccag aatacgactt ggagctcata acatcatgct     8700

cctccaacgt gtcagtcgcc cacgacggcg ctggaaaaag ggtctactac ctcacccgtg     8760

accctacaac ccccctcgcg cgggccgcgt gggagacagc aagacacact ccagtcaatt     8820

cctggctagg caacataatt atgtttgccc ccacactgtg ggcgaggatg atactgatga     8880

cccatttctt tagcgtcctc atagccaggg atcagcttga acaggccctc gattgcgaga     8940

tctacggggc ctgctactcc atagaaccac tggatctacc tccaatcatt caaagactcc     9000

atggcctcag cgcattttca ctccacagtt actctccagg tgaaatcaat agggtggccg     9060

catgcctcag aaaacttggg gtcccgccct tgcgagcttg gagacaccgg gcccggaatg     9120

tccgcgctag gcttctgtcc agaggaggca gggctgccat ttgtggcaag tacctcttca     9180

actgggcagt aaggacaaag ctcaaactca ctccaatagc ggccgctggc cggctagact     9240

tatctggctg gttcacggct ggctacagcg ggggaggcat ttttcacagc gtgtctcatg     9300

cccggccccg ctggttctgg ttttgcctac tcctgctcgc tgcaggggta ggcatctacc     9360

tcctccccaa ccgatgaagg ttggggtaaa cactccggcc tcttaggcca tttcctgttt     9420

tttttttttt tttttttttt tttttttttt tttttttttt tttctttttc cctctttttc     9480

ttctcttttt ccttctttaa tggtggctcc atcttagccc tagtcacggc tagctgtgaa     9540

aggtccgtga gccgcatgac tgcagagagt gctgatactg gcctctctgc agatcatgt      9599


<210>  141
<211>  9599
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid

<400>  141
gccagccccc tgatgggggc gacactccac catgaatcac tcccctgtga ggaactactg       60

tcttcacgca gaaagcgtct agccatggcg ttagtatgag tgtcgtgcag cctccaggac      120

cccccctccc gggagagcca tagtggtctg cggaaccggt gagtacaccg gaattgccag      180

gacgaccggg tcctttcttg gatcaacccg ctcaatgcct ggagatttgg gcgtgccccc      240

gcaagactgc tagccgagta gtgttgggtc gcgaaaggcc ttgtggtact gcctgatagg      300

gtgcttgcga gtgccccggg aggtctcgta gaccgtgcac catgagcacg aatcctaaac      360

ctcaaagaaa aaccaaacgt aacaccaacc gtcgcccaca ggacgtcaag ttcccgggtg      420

gcggtcagat cgttggtgga gtttacttgt tgccgcgcag gggccctaga ttgggtgtgc      480

gcgcgacgag gaagacttcc gagcggtcgc aacctcgagg tagacgtcag cctatcccca      540

aggcgcgtcg gcccgagggc aggacctggg ctcagcccgg gtacccttgg cccctctatg      600

gcaatgaggg ttgcgggtgg gcgggatggc tcctgtctcc ccgtggctct cggcctagct      660

ggggccccac ggacccccgg cgtaggtcgc gcaatttggg taaggtcatc gataccctta      720

cgtgcggctt cgccgacctc atggggtaca taccgctcgt cggcgcccct cttggaggcg      780

ctgccagggc cctggcgcat ggcgtccggg ttttggaaga cggcgtgaac tatgcaacag      840

ggaaccttcc tggttgctct ttctctattt tccttctggc cctgctctct tgtctgactg      900

gacccgcttc agcctaccaa gtgcgcaact ccacggggct ttaccatgtc accaatgatt      960

gccccaactc gagcattgtg ttcgaggcgg ctgatgccat cctgcacact ccggggtgtg     1020

tcccttgcgt acgcgagggt aacgcctcga ggtgttgggt ggcggtaacc cccacggtgg     1080

ccaccaggga tggcaaactc cccacaacgc agcttcgacg tcacatcgat ctgcttgtcg     1140

ggagcgccac cctctgctcg gccctttacg tgggggacct gtgcgggtct gtctttcttg     1200

ttggtcaact gttcaccttc tctcccaggc gccactggac gacgcaagat tgcaattgtt     1260

ctatctaccc cggccatatt tcaggtcacc gtatggcatg ggatatgatg atgaactggt     1320

cccctacggc ggcgttgttg gtagctcagc tgctccggat cccacaagcc atcctggaca     1380

tgatcgctgg tgctcactgg ggagtcctgg cgggcatggc gtatttctcc atggtgggga     1440

actgggcgaa ggttctggta gtgctgctgc tatttgccgg cgtcgacgcg gaaacctacg     1500

tcaccggggg aagtgccgcc cgtactacgg ctggacttgc tagtcttttc tcaccaggcg     1560

ccaagcagaa catccagctg gtcaacacca acggcagttg gcacatcaat agcacggcct     1620

tgaactgcaa tgacagcctc aacaccggct ggatagcagg acttttctat caccacaaat     1680

tcaactcttc gggctgttcc gagaggttag ccagctgccg accccttacc gattttgccc     1740

agggctgggg ccctatcagt cacgccgacg gaagtggccc cgaccaacgc ccctactgct     1800

ggcactaccc tccaaaacct tgtggtattg tgcccgcaaa gagcgtgtgt ggcccggtat     1860

attgtttcac tcccagtccc gtggtggtgg gaacgaccga caggtcgggc gcgcctacct     1920

acagctgggg tgcaaatgac acggacgtct tcgtccttaa caacaccagg ccaccgctgg     1980

gcaattggtt cggttgcacc tggatgaact caactggatt caccaaagtg tgcggagcgc     2040

ccccttgcgt catcggaggg gtgggcaaca acaccttgcg ctgccccact gattgtttcc     2100

gcaagcatcc ggaagccaca tactctcggt gcggctccgg tccctggatt acgcccaggt     2160

gcctggtcga ctacccgtat aggctttggc attatccttg taccatcaac tacaccgtgt     2220

ttaaagtcag gatgtacgtg ggaggggtcg agcacaggct ggaagctgcc tgcaactgga     2280

cgcggggcga ccgttgtaat ctggatgaca gggacaggtc cgagctcagc ccgctgctgc     2340

tgtccactac gcagtggcag gtcctcccgt gttccttcac gaccctgcca gccttgtcca     2400

ccggcctcat ccacctccac caaaacatcg tggacgtgca atacttgtac ggggtgggat     2460

caagcatcgc gtcctgggcc atcaagtggg aatacgtcgt tctcttgttc cttctgcttg     2520

cagacgcgcg cgtctgctcc tgcttgtgga tgatgttact catatcccaa gtggaggcgg     2580

ctttggagaa cctcgtagta ctcaatgcag catccctggc cgggacacac ggtcttgtat     2640

ccttcctcgt gttcttctgc tttgcatggt atctgaaggg taagtgggtg cccggagcgg     2700

tctacgccct ctacgggatg tggcctctcc tcttgctcct gttagcgttg ccccagcggg     2760

catacgcact ggacacggag gtggccgcgt cgtgtggcgg cgttgttctt gtcgggttaa     2820

tggcgctgac tctgtcacca tattacaagc gctatatcag ctggtgcttg tggtggcttc     2880

agtatttcct gaccagaata gaagcgcaac tgcacgtgtg gattccccct ctcaacgtcc     2940

ggggggggcg cgatgccgtc atcttactca tgtgtgttgt gcacccggct ctggtatttg     3000

acatcaccaa gctactgctg gctgccttcg ggcccctttg gattcttcaa gccagtttgc     3060

ttaaggtacc ctacttcgtg cgcgttcaag gccttctccg gatctgcgcg ctagcgcgga     3120

agatggctgg aggccattac gtgcaaatgg ccatcatcaa gttaggggcg cttactggca     3180

cttatgttta caaccatctc accccccttc gggactgggc gcacaacggc ctgcgagatc     3240

tggccgtggc tgtggagcca gtcgtcttct cccgaatgga gaccaagctt atcacctggg     3300

gggcagacac cgccgcgtgc ggtgacatca tcaacggctt gcccgtctcc gcccggaggg     3360

gccgggagat actgctcggg ccagccgatg gaatggtctc caaggggtgg agattgctgg     3420

cgcccatcac ggcgtacgcc cagcaaacga ggggcctcct agggtgtata atcaccagtc     3480

tgaccggccg ggacaaaaac caagtggagg gtgagatcca gattgtgtca actgctgccc     3540

aaaccttcct ggcaacgtgc atcaacgggg tttgctggac cgtctaccac ggggccggaa     3600

cgaggaccat cgcatcaccc aagggtccgg ttatccaaat gtataccaat gtggacaaag     3660

accttgtggg ctggcccgct cctcaaggtg cccgctcact gacaccctgt acctgcggct     3720

cctcggacct ttacctggtc acgaggcacg ccgatgtcat tcccgtgcgc cggcggggtg     3780

atagcagggg cagcctgctt tcgccccggc ccatttccta cttgaaaggc tcctcggggg     3840

gtccgctgct gtgccccgcg ggacacgccg taggcttatt cagggccgcg gtgtgcaccc     3900

gtggagtggc taaggcggtg gacttcatcc ctgtggagaa cctagagaca accatgaggt     3960

ccccggtgtt cacggacaac tcctctccac cagcagtgcc ccagagcttc caggtgggcc     4020

acctgcatgc tcccaccggc agcggcaaaa gcaccaaggt cccggctgca tacgcagctc     4080

agggctataa ggtgctagtg ctcaacccct ctgtcgctgc aacactgggc tttggtgctt     4140

acatgtccaa ggcccatggg gtcgatccta atatcaggac cggggtgaga acaattacca     4200

ctggcagccc catcacgtac tccacctacg gcaagttcct tgccgacggc gggtgttcag     4260

ggggtgctta tgacataata atttgtgacg agtgccactc cacggatgcc acatccatct     4320

tgggcatcgg caccgttctt gaccaagcag agaccgcggg ggcgagactg gttgtgctcg     4380

ccaccgctac ccctccgggc tccatcaccg tgccccatcc taacatcgag gaggttgctc     4440

tgtccactac cggagagatc cctttttacg gcaaggctat ccccctcgag gcgatcaagg     4500

gggggagaca tctcatcttc tgtcactcaa agaagaagtg cgacgagctc gccgcaaagc     4560

tggtcgcatt gggcatcaat gccgtggcct actaccgcgg tcttgacgtg tctgtcatcc     4620

caaccagcgg cgatgttgtc gtcgtggcga ccgatgctct tatgactggc tataccggcg     4680

actttgactc ggtgatagac tgcaacacgt gtgtcaccca gacagtcgac ctcagccttg     4740

accctacctt caccattgag acgaccacgc tcccccagga cgctgtctcc cgcacacaac     4800

gccggggcag gactggcagg gggaagccag gcatctacag attcgtggca ctgggggagc     4860

gcccctccgg catgttcgac tcgtccgttc tctgtgagtg ctatgacgcg ggctgtgctt     4920

ggtatgagct cacgcccgcc gagactacag ttagactacg agcgtacatg aacaccccgg     4980

ggctccctgt gtgccaggac catcttgaat tttgggaggg cgtctttaca ggcctcaccc     5040

atatagatgc ccatttccta tctcagacaa agcagagcgg ggaaaacttt ccttacctgg     5100

tagcatacca agcaaccgtg tgcgctaggg ctcaagcccc tcccccatcg tgggaccaga     5160

tgtggaagtg tttgactcgc ctcaagccca ccctccatgg gccaacaccc ttgctataca     5220

gactgggcgc tgttcagaat gaagtcaccc tgacgcaccc aatcaccaaa tacatcatga     5280

catgcatgtc ggccgacctg gaggtcgtca cgagcacctg ggtgctcgtc ggcggcgtcc     5340

tggccgcttt ggcctcgtat tgcctgtcaa caggctgcgt ggtcatagtg ggcaggattg     5400

tcctgtctgg gaagccggca attatacctg acagggaagt tctctaccgg gagttcgatg     5460

agatggaaga gtgctctcag cacttaccgt acatcgagca agggatgatg ctcgccgagc     5520

agttcaagca gaaggccctc ggcctcctgc agaccgcgtc ccgtcaggca gaggttgtcg     5580

cccctgctgt ccagaccaac tggcaaaaac tcgaggcctt ctgggcgaag catatgtgga     5640

acttcatcag tgggatacac tacttggcgg gcttgtcaac gttgcctggt aaccccgcca     5700

ttgcttcatt gatggctttt acagctgctg tcaccagccc actaaccact agccaaaccc     5760

tcctcttcaa catactgggg gggtgggtgg ctgcccagct tgccgccccc ggtgccgcca     5820

ccgcctttgt gggcgctggc ttagccggcg ccgcaatcgg cagtgttgga ctggggaagg     5880

tcctcgtgga cattctagca gggtatggcg cgggcgtggc gggagctctt gtagcattca     5940

agatcatgag cggtgaggtc ccctccacgg aggacctagt caacctgctg cccgccatcc     6000

tctcgcctgg agcccttgta gtcggtgtgg tctgcgcagc aatactgcgc cggcacgtcg     6060

gcccgggcga gggggcagtg caatggatga accggctaat cgccttcgcc tcccggggga     6120

accatgtttc ccccacgcac tatgtgccgg agagcgatgc agctgcccgc gtcactacca     6180

tactcagcag cctcactgta acccagctcc tgaggcgact gcaccagtgg ataagctcgg     6240

agtgtaccac tccatgctcc ggttcctggc tgagggacat ctgggactgg atatgcgagg     6300

tgctgagcga ctttaagacc tggctgaaag ccaagctcat gccgcaactg cctgggattc     6360

cctttgtgtc ctgccagcgt gggtataagg gggtctggcg aggggacggc atcatgcaca     6420

ctcgctgcca ctgtggagct gagataactg gacatgtcaa aaacgggacg atgaggatcg     6480

ttggtcctaa gacttgcagg aacatgtgga gtgggacttt ccccattaac gcctacacca     6540

cgggcccctg tactcccctt cctgcgccga actatacgtt cgcgctgtgg agggtgtctg     6600

cagaggaata cgtggagata aggcaggtgg gggacttcca ctacgtgacg ggtatgacta     6660

ctgacaacct taaatgcccg tgccaggtcc catcgcccga atttttcaca gaattggacg     6720

gggtgcgcct acataggttt gcgccccctt gcaagcccct gctgcgggag gaggtgtcat     6780

tcagagtggg actccacgag tacccggtgg ggtcgcaatt accttgcgag cccgaaccgg     6840

acgtggccgt gttgacgtcc atgctcactg atccctccca tataacagca gaggcggccg     6900

ggagaaggtt ggcgagggga tcacccccct ctatggccag ctcctcggct agccaactgt     6960

ccgctccatc tctcagggca acttgcacta ccaaccatga ctcccctgat gctgagctca     7020

tagaggccaa cctcctatgg aggcaggaga tgggcggcaa catcaccagg gttgagtcag     7080

agaacaaagt ggtgattctg gactccttcg atccgcttgt ggcagaggag gatgagcggg     7140

aggtctccgt gcccgcagag atactgcgga agtctcggaa attcacccca gccctaccca     7200

tttgggcgcg gccggactat aaccccccgc tggtggagcc gtggaaaaag cctgactacg     7260

aaccacctgt ggtccatggc tgcccgcttc cacctccaca gtcccctcct gtgcctccac     7320

ctcggaagaa gcggacggtg atcctcaccg aatcaaccct acctactgcc ttggccgagc     7380

ttgccaccaa aagttttggc agctcctcaa cttccggcat tacgggcgac gacacgacaa     7440

catcccctga gcccgcctcc tctagctgcc ctcccgactc cgacgctgag tcctattctt     7500

ccatgccccc tctggagggg gagcctgggg atccggatct cagcgacggg tcatggtcga     7560

cggtcagtag tgaggccgac aaggaggatg tcgtgtgctg ctcaatgtct tatacctgga     7620

caggcgcact cgtcaccccg tgcgccgcgg aagaacaaaa actgcccatc aacgcactaa     7680

gcaactcgtt gctgcgtcat cacaatctgg tgtattccac cacctcacgc agtgcttgcc     7740

aaaggcagaa gaaagtcaca tttgacagac tgcaagtcct ggacagccat taccaggacg     7800

tgctcaagga ggttaaggca gcggcgtcaa aagtgaaggc taacttgcta tccgtagagg     7860

aagcttgcag cctgacgccc ccacactcag ccaaatccaa gtttggctat ggggcaaaag     7920

acgtccgttg ccatgccaga aaggccgtaa accacatcaa ctccgtgtgg aaagaccttc     7980

tggaagacag tgtaacacca atagacacta ccatcatggc taagaacgag gttttctgcg     8040

ttcagcctga gaaggggggt cgtaagccag ctcgtctcat cgtgttcccc gacctgggtg     8100

tacgcgtgtg cgagaagatg gccttgtacg acgtagtcag caagctcccc ctagccgtga     8160

tgggaagctc ctacggattc caatactcac caggacagcg ggttgaattc ctcgtgcaag     8220

cgtggaagtc caagaagacc ccaatggggt tttcgtatga tacccgctgt tttgactcca     8280

cagtcactga gaatgatatc cgtacggagg aggcaatcta ccaatgttgt gacctggacc     8340

cccaagcccg cgtggccatc aagtccctca ctgagaggct ttatgtcggg ggccctctta     8400

ccaattcaag gggggagaac tgcggctatc gcaggtgccg cgcgagcggc gtactgacga     8460

ccagctgtgg taacaccctc acctgctaca tcaaggcccg agcagcctgt cgagccgcag     8520

ggctccagga ctgcaccatg ctcgtgtgtg gcgacgactt agtcgttatc tgtgagagtg     8580

cgggggtcca ggaggacgcg gcgagcctga gagccttcac ggaggctatg accaggtact     8640

ccgccccccc cggggacccc ccacaaccag aatacgactt ggagctcata acatcatgct     8700

cctccaacgt gtcagtcgcc cacgacggcg ctggaaaaag ggtctactac ctcacccgtg     8760

accctacaac ccccctcgcg cgggccgcgt gggagacagc aagacacact ccagtcaatt     8820

cctggctagg caacataatt atgtttgccc ccacactgtg ggcgaggatg atactgatga     8880

cccatttctt tagcgtcctc atagccaggg atcagcttga acaggccctc gattgcgaga     8940

tctacggggc ctgctactcc atagaaccac tggatctacc tccaatcatt caaagactcc     9000

atggcctcag cgcattttca ctccacagtt actctccagg tgaaatcaat agggtggccg     9060

catgcctcag aaaacttggg gtcccgccct tgcgagcttg gagacaccgg gcccggaatg     9120

tccgcgctag gcttctgtcc agaggaggca gggctgccat ttgtggcaag tacctcttca     9180

actgggcagt aaggacaaag ctcaaactca ctccaatagc ggccgctggc cggctagact     9240

tatctggctg gttcacggct ggctacagcg ggggaggcat ttttcacagc gtgtctcatg     9300

cccggccccg ctggttctgg tcttgcctac tcctgctcgc tgcaggggta ggcatctacc     9360

tcctccccaa ccgatgaagg ttggggtaaa cactccggcc tcttaggcca tttcctgttt     9420

tttttttttt tttttttttt tttttttttt tttttttttt tttctttttc cctctttttc     9480

ttctcttttt ccttctttaa tggtggctcc atcttagccc tagtcacggc tagctgtgaa     9540

aggtccgtga gccgcatgac tgcagagagt gctgatactg gcctctctgc agatcatgt      9599


<210>  142
<211>  9599
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid

<400>  142
gccagccccc tgatgggggc gacactccac catgaatcac tcccctgtga ggaactactg       60

tcttcacgca gaaagcgtct agccatggcg ttagtatgag tgtcgtgcag cctccaggac      120

cccccctccc gggagagcca tagtggtctg cggaaccggt gagtacaccg gaattgccag      180

gacgaccggg tcctttcttg gatcaacccg ctcaatgcct ggagatttgg gcgtgccccc      240

gcaagactgc tagccgagta gtgttgggtc gcgaaaggcc ttgtggtact gcctgatagg      300

gtgcttgcga gtgccccggg aggtctcgta gaccgtgcac catgagcacg aatcctaaac      360

ctcaaagaaa aaccaaacgt aacaccaacc gtcgcccaca ggacgtcaag ttcccgggtg      420

gcggtcagat cgttggtgga gtttacttgt tgccgcgcag gggccctaga ttgggtgtgc      480

gcgcgacgag gaagacttcc gagcggtcgc aacctcgagg tagacgtcag cctatcccca      540

aggcgcgtcg gcccgagggc aggacctggg ctcagcccgg gtacccttgg cccctctatg      600

gcaatgaggg ttgcgggtgg gcgggatggc tcctgtctcc ccgtggctct cggcctagct      660

ggggccccac ggacccccgg cgtaggtcgc gcaatttggg taaggtcatc gataccctta      720

cgtgcggctt cgccgacctc atggggtaca taccgctcgt cggcgcccct cttggaggcg      780

ctgccagggc cctggcgcat ggcgtccggg ttttggaaga cggcgtgaac tatgcaacag      840

ggaaccttcc tggttgctct ttctctattt tccttctggc cctgctctct tgtctgactg      900

gacccgcttc agcctaccaa gtgcgcaact ccacggggct ttaccatgtc accaatgatt      960

gccccaactc gagcattgtg ttcgaggcgg ctgatgccat cctgcacact ccggggtgtg     1020

tcccttgcgt acgcgagggt aacgcctcga ggtgttgggt ggcggtaacc cccacggtgg     1080

ccaccaggga tggcaaactc cccacaacgc agcttcgacg tcacatcgat ctgcttgtcg     1140

ggagcgccac cctctgctcg gccctttacg tgggggacct gtgcgggtct gtctttcttg     1200

ttggtcaact gttcaccttc tctcccaggc gccactggac gacgcaagat tgcaattgtt     1260

ctatctaccc cggccatatt tcaggtcacc gtatggcatg ggatatgatg atgaactggt     1320

cccctacggc ggcgttgttg gtagctcagc tgctccggat cccacaagcc atcctggaca     1380

tgatcgctgg tgctcactgg ggagtcctgg cgggcatggc gtatttctcc atggtgggga     1440

actgggcgaa ggttctggta gtgctgctgc tatttgccgg cgtcgacgcg gaaacctacg     1500

tcaccggggg aagtgccgcc cgtactacgg ctggacttgc tagtcttttc tcaccaggcg     1560

ccaagcagaa catccagctg gtcaacacca acggcagttg gcacatcaat agcacggcct     1620

tgaactgcaa tgacagcctc aacaccggct ggatagcagg acttttctat caccacaaat     1680

tcaactcttc gggctgttcc gagaggttag ccagctgccg accccttacc gattttgccc     1740

agggctgggg ccctatcagt cacgccgacg gaagtggccc cgaccaacgc ccctactgct     1800

ggcactaccc tccaaaacct tgtggtattg tgcccgcaaa gagcgtgtgt ggcccggtat     1860

attgtttcac tcccagtccc gtggtggtgg gaacgaccga caggtcgggc gcgcctacct     1920

acagctgggg tgcaaatgac acggacgtct tcgtccttaa caacaccagg ccaccgctgg     1980

gcaattggtt cggttgcacc tggatgaact caactggatt caccaaagtg tgcggagcgc     2040

ccccttgcgt catcggaggg gtgggcaaca acaccttgcg ctgccccact gattgtttcc     2100

gcaagcatcc ggaagccaca tactctcggt gcggctccgg tccctggatt acgcccaggt     2160

gcctggtcga ctacccgtat aggctttggc attatccttg taccatcaac tacaccgtgt     2220

ttaaagtcag gatgtacgtg ggaggggtcg agcacaggct ggaagctgcc tgcaactgga     2280

cgcggggcga ccgttgtaat ctggatgaca gggacaggtc cgagctcagc ccgctgctgc     2340

tgtccactac gcagtggcag gtcctcccgt gttccttcac gaccctgcca gccttgtcca     2400

ccggcctcat ccacctccac caaaacatcg tggacgtgca atacttgtac ggggtgggat     2460

caagcatcgc gtcctgggcc atcaagtggg aatacgtcgt tctcttgttc cttctgcttg     2520

cagacgcgcg cgtctgctcc tgcttgtgga tgatgttact catatcccaa gtggaggcgg     2580

ctttggagaa cctcgtagta ctcaatgcag catccctggc cgggacacac ggtcttgtat     2640

ccttcctcgt gttcttctgc tttgcatggt atctgaaggg taagtgggtg cccggagcgg     2700

tctacgccct ctacgggatg tggcctctcc tcttgctcct gttagcgttg ccccagcggg     2760

catacgcact ggacacggag gtggccgcgt cgtgtggcgg cgttgttctt gtcgggttaa     2820

tggcgctgac tctgtcacca tattacaagc gctatatcag ctggtgcttg tggtggcttc     2880

agtatttcct gaccagaata gaagcgcaac tgcacgtgtg gattccccct ctcaacgtcc     2940

ggggggggcg cgatgccgtc atcttactca tgtgtgttgt gcacccggct ctggtatttg     3000

acatcaccaa gctactgctg gctgccttcg ggcccctttg gattcttcaa gccagtttgc     3060

ttaaggtacc ctacttcgtg cgcgttcaag gccttctccg gatctgcgcg ctagcgcgga     3120

agatggctgg aggccattac gtgcaaatgg ccatcatcaa gttaggggcg cttactggca     3180

cttatgttta caaccatctc accccccttc gggactgggc gcacaacggc ctgcgagatc     3240

tggccgtggc tgtggagcca gtcgtcttct cccgaatgga gaccaagctt atcacctggg     3300

gggcagacac cgccgcgtgc ggtgacatca tcaacggctt gcccgtctcc gcccggaggg     3360

gccgggagat actgctcggg ccagccgatg gaatggtctc caaggggtgg agattgctgg     3420

cgcccatcac ggcgtacgcc cagcaaacga ggggcctcct agggtgtata atcaccagtc     3480

tgaccggccg ggacaaaaac caagtggagg gtgagatcca gattgtgtca actgctgccc     3540

aaaccttcct ggcaacgtgc atcaacgggg tttgctggac cgtctaccac ggggccggaa     3600

cgaggaccat cgcatcaccc aagggtccgg ttatccaaat gtataccaat gtggacaaag     3660

accttgtggg ctggcccgct cctcaaggtg cccgctcact gacaccctgt acctgcggct     3720

cctcggacct ttacctggtc acgaggcacg ccgatgtcat tcccgtgcgc cggcggggtg     3780

atagcagggg cagcctgctt tcgccccggc ccatttccta cttgaaaggc tcctcggggg     3840

gtccgctgct gtgccccgcg ggacacgccg taggcttatt cagggccgcg gtgtgcaccc     3900

gtggagtggc taaggcggtg gacttcatcc ctgtggagaa cctagagaca accatgaggt     3960

ccccggtgtt cacggacaac tcctctccac cagcagtgcc ccagagcttc caggtgggcc     4020

acctgcatgc tcccaccggc agcggcaaaa gcaccaaggt cccggctgca tacgcagctc     4080

agggctataa ggtgctagtg ctcaacccct ctgtcgctgc aacactgggc tttggtgctt     4140

acatgtccaa ggcccatggg gtcgatccta atatcaggac cggggtgaga acaattacca     4200

ctggcagccc catcacgtac tccacctacg gcaagttcct tgccgacggc gggtgttcag     4260

ggggtgctta tgacataata atttgtgacg agtgccactc cacggatgcc acatccatct     4320

tgggcatcgg caccgttctt gaccaagcag agaccgcggg ggcgagactg gttgtgctcg     4380

ccaccgctac ccctccgggc tccatcaccg tgccccatcc taacatcgag gaggttgctc     4440

tgtccactac cggagagatc cctttttacg gcaaggctat ccccctcgag gcgatcaagg     4500

gggggagaca tctcatcttc tgtcactcaa agaagaagtg cgacgagctc gccgcaaagc     4560

tggtcgcatt gggcatcaat gccgtggcct actaccgcgg tcttgacgtg tctgtcatcc     4620

caaccagcgg cgatgttgtc gtcgtggcga ccgatgctct tatgactggc tataccggcg     4680

actttgactc ggtgatagac tgcaacacgt gtgtcaccca gacagtcgac ctcagccttg     4740

accctacctt caccattgag acgaccacgc tcccccagga cgctgtctcc cgcacacaac     4800

gccggggcag gactggcagg gggaagccag gcatctacag attcgtggca ctgggggagc     4860

gcccctccgg catgttcgac tcgtccgttc tctgtgagtg ctatgacgcg ggctgtgctt     4920

ggtatgagct cacgcccgcc gagactacag ttagactacg agcgtacatg aacaccccgg     4980

ggctccctgt gtgccaggac catcttgaat tttgggaggg cgtctttaca ggcctcaccc     5040

atatagatgc ccatttccta tctcagacaa agcagagcgg ggaaaacttt ccttacctgg     5100

tagcatacca agcaaccgtg tgcgctaggg ctcaagcccc tcccccatcg tgggaccaga     5160

tgtggaagtg tttgactcgc ctcaagccca ccctccatgg gccaacaccc ttgctataca     5220

gactgggcgc tgttcagaat gaagtcaccc tgacgcaccc aatcaccaaa tacatcatga     5280

catgcatgtc ggccgacctg gaggtcgtca cgagcacctg ggtgctcgtc ggcggcgtcc     5340

tggccgcttt ggcctcgtat tgcctgtcaa caggctgcgt ggtcatagtg ggcaggattg     5400

tcctgtctgg gaagccggca attatacctg acagggaagt tctctaccgg gagttcgatg     5460

agatggaaga gtgctctcag cacttaccgt acatcgagca agggatgatg ctcgccgagc     5520

agttcaagca gaaggccctc ggcctcctgc agaccgcgtc ccgtcaggca gaggttgtcg     5580

cccctgctgt ccagaccaac tggcaaaaac tcgaggcctt ctgggcgaag catatgtgga     5640

acttcatcag tgggatacaa tacttggcgg gcttgtcaac gttgcctggt aaccccgcca     5700

ttgcttcatt gatggctttt acagctgctg tcaccagccc actaaccact agccaaaccc     5760

tcctcttcaa catactgggg gggtgggtgg ctgcccagct tgccgccccc ggtgccgcca     5820

ccgcctttgt gggcgctggc ttagccggcg ccgcaatcgg cagtgttgga ctggggaagg     5880

tcctcgtgga cattctagca gggtatggcg cgggcgtggc gggagctctt gtagcattca     5940

agatcatgag cggtgaggtc ccctccacgg aggacctagt caacctgctg cccgccatcc     6000

tctcgcctgg agcccttgta gtcggtgtgg tctgcgcagc aatactgcgc cggcacgtcg     6060

gcccgggcga gggggcagtg caatggatga accggctaat cgccttcgcc tcccggggga     6120

gccatgtttc ccccacgcac tatgtgccgg agagcgatgc agctgcccgc gtcactacca     6180

tactcagcag cctcactgta acccagctcc tgaggcgact gcaccagtgg ataagctcgg     6240

agtgtaccac tccatgctcc ggttcctggc tgagggacat ctgggactgg atatgcgagg     6300

tgctgagcga ctttaagacc tggctgaaag ccaagctcat gccgcaactg cctgggattc     6360

cctttgtgtc ctgccagcgt gggtataagg gggtctggcg aggggacggc atcatgcaca     6420

ctcgctgcca ctgtggagct gagataactg gacatgtcaa aaacgggacg atgaggatcg     6480

ttggtcctaa gacttgcagg aacatgtgga gtgggacttt ccccattaac gcctacacca     6540

cgggcccctg tactcccctt cctgcgccga actatacgtt cgcgctgtgg agggtgtctg     6600

cagaggaata cgtggagata aggcaggtgg gggacttcca ctacgtgacg ggtatgacta     6660

ctgacaacct taaatgcccg tgccaggtcc catcgcccga atttttcaca gaattggacg     6720

gggtgcgcct acataggttt gcgccccctt gcaagcccct gctgcgggag gaggtgtcat     6780

tcagagtggg actccacgag tacccggtgg ggtcgcaatt accttgcgag cccgaaccgg     6840

acgtggccgt gttgacgtcc atgctcactg atccctccca tataacagca gaggcggccg     6900

ggagaaggtt ggcgagggga tcacccccct ctatggccag ctcctcggct agccaactgt     6960

ccgctccatc tctcagggca acttgcacta ccaaccatga ctcccctgat gctgagctca     7020

tagaggccaa cctcctatgg aggcaggaga tgggcggcaa catcaccagg gttgagtcag     7080

agaacaaagt ggtgattctg gactccttcg atccgcttgt ggcagaggag gatgagcggg     7140

aggtctccgt gcccgcagag atactgcgga agtctcggaa attcacccca gccctaccca     7200

tttgggcgcg gccggactat aaccccccgc tggtggagcc gtggaaaaag cctgactacg     7260

aaccacctgt ggtccatggc tgcccgcttc cacctccaca gtcccctcct gtgcctccac     7320

ctcggaagaa gcggacggtg atcctcaccg aatcaaccct acctactgcc ttggccgagc     7380

ttgccaccaa aagttttggc agctcctcaa cttccggcat tacgggcgac gacacgacaa     7440

catcccctga gcccgcctcc tctagctgcc ctcccgactc cgacgctgag tcctattctt     7500

ccatgccccc tctggagggg gagcctgggg atccggatct cagcgacggg tcatggtcga     7560

cggtcagtag tgaggccgac aaggaggatg tcgtgtgctg ctcaatgtct tatacctgga     7620

caggcgcact cgtcaccccg tgcgccgcgg aagaacaaaa actgcccatc aacgcactaa     7680

gcaactcgtt gctgcgtcat cacaatctgg tgtattccac cacctcacgc agtgcttgcc     7740

aaaggcagaa gaaagtcaca tttgacagac tgcaagtcct ggacagccat taccaggacg     7800

tgctcaagga ggttaaggca gcggcgtcaa aagtgaaggc taacttgcta tccgtagagg     7860

aagcttgcag cctgacgccc ccacactcag ccaaatccaa gtttggctat ggggcaaaag     7920

acgtccgttg ccatgccaga aaggccgtaa accacatcaa ctccgtgtgg aaagaccttc     7980

tggaagacag tgtaacacca atagacacta ccatcatggc taagaacgag gttttctgcg     8040

ttcagcctga gaaggggggt cgtaagccag ctcgtctcat cgtgttcccc gacctgggtg     8100

tacgcgtgtg cgagaagatg gccttgtacg acgtagtcag caagctcccc ctagccgtga     8160

tgggaagctc ctacggattc caatactcac caggacagcg ggttgaattc ctcgtgcaag     8220

cgtggaagtc caagaagacc ccaatggggt tttcgtatga tacccgctgt tttgactcca     8280

cagtcactga gaatgatatc cgtacggagg aggcaatcta ccaatgttgt gacctggacc     8340

cccaagcccg cgtggccatc aagtccctca ctgagaggct ttatgtcggg ggccctctta     8400

ccaattcaag gggggagaac tgcggctatc gcaggtgccg cgcgagcggc gtactgacga     8460

ccagctgtgg taacaccctc acctgctaca tcaaggcccg agcagcctgt cgagccgcag     8520

ggctccagga ctgcaccatg ctcgtgtgtg gcgacgactt agtcgttatc tgtgagagtg     8580

cgggggtcca ggaggacgcg gcgagcctga gagccttcac ggaggctatg accaggtact     8640

ccgccccccc cggggacccc ccacaaccag aatacgactt ggagctcata acatcatgct     8700

cctccaacgt gtcagtcgcc cacgacggcg ctggaaaaag ggtctactac ctcacccgtg     8760

accctacaac ccccctcgcg cgggccgcgt gggagacagc aagacacact ccagtcaatt     8820

cctggctagg caacataatt atgtttgccc ccacactgtg ggcgaggatg atactgatga     8880

cccatttctt tagcgtcctc atagccaggg atcagcttga acaggccctc gattgcgaga     8940

tctacggggc ctgctactcc atagaaccac tggatctacc tccaatcatt caaagactcc     9000

atggcctcag cgcattttca ctccacagtt actctccagg tgaaatcaat agggtggccg     9060

catgcctcag aaaacttggg gtcccgccct tgcgagcttg gagacaccgg gcccggaatg     9120

tccgcgctag gcttctgtcc agaggaggca gggctgccat ttgtggcaag tacctcttca     9180

actgggcagt aaggacaaag ctcaaactca ctccaatagc ggccgctggc cggctagact     9240

tatctggctg gttcacggct ggctacagcg ggggaggcat ttttcacagc gtgtctcatg     9300

cccggccccg ctggttctgg tcttgcctac tcctgctcgc tgcaggggta ggcatctacc     9360

tcctccccaa ccgatgaagg ttggggtaaa cactccggcc tcttaggcca tttcctgttt     9420

tttttttttt tttttttttt tttttttttt tttttttttt tttctttttc cctctttttc     9480

ttctcttttt ccttctttaa tggtggctcc atcttagccc tagtcacggc tagctgtgaa     9540

aggtccgtga gccgcatgac tgcagagagt gctgatactg gcctctctgc agatcatgt      9599


<210>  143
<211>  9599
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid

<400>  143
gccagccccc tgatgggggc gacactccac catgaatcac tcccctgtga ggaactactg       60

tcttcacgca gaaagcgtct agccatggcg ttagtatgag tgtcgtgcag cctccaggac      120

cccccctccc gggagagcca tagtggtctg cggaaccggt gagtacaccg gaattgccag      180

gacgaccggg tcctttcttg gatcaacccg ctcaatgcct ggagatttgg gcgtgccccc      240

gcaagactgc tagccgagta gtgttgggtc gcgaaaggcc ttgtggtact gcctgatagg      300

gtgcttgcga gtgccccggg aggtctcgta gaccgtgcac catgagcacg aatcctaaac      360

ctcaaagaaa aaccaaacgt aacaccaacc gtcgcccaca ggacgtcaag ttcccgggtg      420

gcggtcagat cgttggtgga gtttacttgt tgccgcgcag gggccctaga ttgggtgtgc      480

gcgcgacgag gaagacttcc gagcggtcgc aacctcgagg tagacgtcag cctatcccca      540

aggcgcgtcg gcccgagggc aggacctggg ctcagcccgg gtacccttgg cccctctatg      600

gcaatgaggg ttgcgggtgg gcgggatggc tcctgtctcc ccgtggctct cggcctagct      660

ggggccccac ggacccccgg cgtaggtcgc gcaatttggg taaggtcatc gataccctta      720

cgtgcggctt cgccgacctc atggggtaca taccgctcgt cggcgcccct cttggaggcg      780

ctgccagggc cctggcgcat ggcgtccggg ttttggaaga cggcgtgaac tatgcaacag      840

ggaaccttcc tggttgctct ttctctattt tccttctggc cctgctctct tgtctgactg      900

gacccgcttc agcctaccaa gtgcgcaact ccacggggct ttaccatgtc accaatgatt      960

gccccaactc gagcattgtg ttcgaggcgg ctgatgccat cctgcacact ccggggtgtg     1020

tcccttgcgt acgcgagggt aacgcctcga ggtgttgggt ggcggtaacc cccacggtgg     1080

ccaccaggga tggcaaactc cccacaacgc agcttcgacg tcacatcgat ctgcttgtcg     1140

ggagcgccac cctctgctcg gccctttacg tgggggacct gtgcgggtct gtctttcttg     1200

ttggtcaact gttcaccttc tctcccaggc gccactggac gacgcaagat tgcaattgtt     1260

ctatctaccc cggccatatt tcaggtcacc gtatggcatg ggatatgatg atgaactggt     1320

cccctacggc ggcgttgttg gtagctcagc tgctccggat cccacaagcc atcctggaca     1380

tgatcgctgg tgctcactgg ggagtcctgg cgggcatggc gtatttctcc atggtgggga     1440

actgggcgaa ggttctggta gtgctgctgc tatttgccgg cgtcgacgcg gaaacctacg     1500

tcaccggggg aagtgccgcc cgtactacgg ctggacttgc tagtcttttc tcaccaggcg     1560

ccaagcagaa catccagctg gtcaacacca acggcagttg gcacatcaat agcacggcct     1620

tgaactgcaa tgacagcctc aacaccggct ggatagcagg acttttctat caccacaaat     1680

tcaactcttc gggctgttcc gagaggttag ccagctgccg accccttacc gattttgccc     1740

agggctgggg ccctatcagt cacgccgacg gaagtggccc cgaccaacgc ccctactgct     1800

ggcactaccc tccaaaacct tgtggtattg tgcccgcaaa gagcgtgtgt ggcccggtat     1860

attgtttcac tcccagtccc gtggtggtgg gaacgaccga caggtcgggc gcgcctacct     1920

acagctgggg tgcaaatgac acggacgtct tcgtccttaa caacaccagg ccaccgctgg     1980

gcaattggtt cggttgcacc tggatgaact caactggatt caccaaagtg tgcggagcgc     2040

ccccttgcgt catcggaggg gtgggcaaca acaccttgcg ctgccccact gattgtttcc     2100

gcaagcatcc ggaagccaca tactctcggt gcggctccgg tccctggatt acgcccaggt     2160

gcctggtcga ctacccgtat aggctttggc attatccttg taccatcaac tacaccgtgt     2220

ttaaagtcag gatgtacgtg ggaggggtcg agcacaggct ggaagctgcc tgcaactgga     2280

cgcggggcga ccgttgtaat ctggatgaca gggacaggtc cgagctcagc ccgctgctgc     2340

tgtccactac gcagtggcag gtcctcccgt gttccttcac gaccctgcca gccttgtcca     2400

ccggcctcat ccacctccac caaaacatcg tggacgtgca atacttgtac ggggtgggat     2460

caagcatcgc gtcctgggcc atcaagtggg aatacgtcgt tctcttgttc cttctgcttg     2520

cagacgcgcg cgtctgctcc tgcttgtgga tgatgttact catatcccaa gtggaggcgg     2580

ctttggagaa cctcgtagta ctcaatgcag catccctggc cgggacacac ggtcttgtat     2640

ccttcctcgt gttcttctgc tttgcatggt atctgaaggg taagtgggtg cccggagcgg     2700

tctacgccct ctacgggatg tggcctctcc tcttgctcct gttagcgttg ccccagcggg     2760

catacgcact ggacacggag gtggccgcgt cgtgtggcgg cgttgttctt gtcgggttaa     2820

tggcgctgac tctgtcacca tattacaagc gctatatcag ctggtgcttg tggtggcttc     2880

agtatttcct gaccagaata gaagcgcaac tgcacgtgtg gattccccct ctcaacgtcc     2940

ggggggggcg cgatgccgtc atcttactca tgtgtgttgt gcacccggct ctggtatttg     3000

acatcaccaa gctactgctg gctgccttcg ggcccctttg gattcttcaa gccagtttgc     3060

ttaaggtacc ctacttcgtg cgcgttcaag gccttctccg gatctgcgcg ctagcgcgga     3120

agatggctgg aggccattac gtgcaaatgg ccatcatcaa gttaggggcg cttactggca     3180

cttatgttta caaccatctc accccccttc gggactgggc gcacaacggc ctgcgagatc     3240

tggccgtggc tgtggagcca gtcgtcttct cccgaatgga gaccaagctt atcacctggg     3300

gggcagacac cgccgcgtgc ggtgacatca tcaacggctt gcccgtctcc gcccggaggg     3360

gccgggagat actgctcggg ccagccgatg gaatggtctc caaggggtgg agattgctgg     3420

cgcccatcac ggcgtacgcc cagcaaacga ggggcctcct agggtgtata atcaccagtc     3480

tgaccggccg ggacaaaaac caagtggagg gtgagatcca gattgtgtca actgctgccc     3540

aaaccttcct ggcaacgtgc atcaacgggg tttgctggac cgtctaccac ggggccggaa     3600

cgaggaccat cgcatcaccc aagggtccgg ttatccaaat gtataccaat gtggacaaag     3660

accttgtggg ctggcccgct cctcaaggtg cccgctcact gacaccctgt acctgcggct     3720

cctcggacct ttacctggtc acgaggcacg ccgatgtcat tcccgtgcgc cggcggggtg     3780

atagcagggg cagcctgctt tcgccccggc ccatttccta cttgaaaggc tcctcggggg     3840

gtccgctgct gtgccccgcg ggacacgccg taggcttatt cagggccgcg gtgtgcaccc     3900

gtggagtggc taaggcggtg gacttcatcc ctgtggagaa cctagagaca accatgaggt     3960

ccccggtgtt cacggacaac tcctctccac cagcagtgcc ccagagcttc caggtgggcc     4020

acctgcatgc tcccaccggc agcggcaaaa gcaccaaggt cccggctgca tacgcagctc     4080

agggctataa ggtgctagtg ctcaacccct ctgtcgctgc aacactgggc tttggtgctt     4140

acatgtccaa ggcccatggg gtcgatccta atatcaggac cggggtgaga acaattacca     4200

ctggcagccc catcacgtac tccacctacg gcaagttcct tgccgacggc gggtgttcag     4260

ggggtgctta tgacataata atttgtgacg agtgccactc cacggatgcc acatccatct     4320

tgggcatcgg caccgttctt gaccaagcag agaccgcggg ggcgagactg gttgtgctcg     4380

ccaccgctac ccctccgggc tccatcaccg tgccccatcc taacatcgag gaggttgctc     4440

tgtccactac cggagagatc cctttttacg gcaaggctat ccccctcgag gcgatcaagg     4500

gggggagaca tctcatcttc tgtcactcaa agaagaagtg cgacgagctc gccgcaaagc     4560

tggtcgcatt gggcatcaat gccgtggcct actaccgcgg tcttgacgtg tctgtcatcc     4620

caaccagcgg cgatgttgtc gtcgtggcga ccgatgctct tatgactggc tataccggcg     4680

actttgactc ggtgatagac tgcaacacgt gtgtcaccca gacagtcgac ctcagccttg     4740

accctacctt caccattgag acgaccacgc tcccccagga cgctgtctcc cgcacacaac     4800

gccggggcag gactggcagg gggaagccag gcatctacag attcgtggca ctgggggagc     4860

gcccctccgg catgttcgac tcgtccgttc tctgtgagtg ctatgacgcg ggctgtgctt     4920

ggtatgagct cacgcccgcc gagactacag ttagactacg agcgtacatg aacaccccgg     4980

ggctccctgt gtgccaggac catcttgaat tttgggaggg cgtctttaca ggcctcaccc     5040

atatagatgc ccatttccta tctcagacaa agcagagcgg ggaaaacttt ccttacctgg     5100

tagcatacca agcaaccgtg tgcgctaggg ctcaagcccc tcccccatcg tgggaccaga     5160

tgtggaagtg tttgactcgc ctcaagccca ccctccatgg gccaacaccc ttgctataca     5220

gactgggcgc tgttcagaat gaagtcaccc tgacgcaccc aatcaccaaa tacatcatga     5280

catgcatgtc ggccgacctg gaggtcgtca cgagcacctg ggtgctcgtc ggcggcgtcc     5340

tggccgcttt ggcctcgtat tgcctgtcaa caggctgcgt ggtcatagtg ggcaggattg     5400

tcctgtctgg gaagccggca attatacctg acagggaagt tctctaccgg gagttcgatg     5460

agatggaaga gtgctctcag cacttaccgt acatcgagca agggatgatg ctcgccgagc     5520

agttcaagca gaaggccctc ggcctcctgc agaccgcgtc ccgtcaggca gaggttgtcg     5580

cccctgctgt ccagaccaac tggcaaaaac tcgaggcctt ctgggcgaag catatgtgga     5640

acttcatcag tgggatacaa tacttggcgg gcttgtcaac gttgcctggt aaccccgcca     5700

ttgcttcatt gatggctttt acagctgctg tcaccagccc actaaccact agccaaaccc     5760

tcctcttcaa catactgggg gggtgggtgg ctgcccagct tgccgccccc ggtgccgcca     5820

ccgcctttgt gggcgctggc ttagccggcg ccgcaatcgg cagtgttgga ctggggaagg     5880

tcctcgtgga cattctagca gggtatggcg cgggcgtggc gggagctctt gtagcattca     5940

agatcatgag cggtgaggtc ccctccacgg aggacctagt caacctgctg cccgccatcc     6000

tctcgcctgg agcccttgta gtcggtgtgg tctgcgcagc aatactgcgc cggcacgtcg     6060

gcccgggcga gggggcagtg caatggatga accggctaat cgccttcgcc tcccggggga     6120

cccatgtttc ccccacgcac tatgtgccgg agagcgatgc agctgcccgc gtcactacca     6180

tactcagcag cctcactgta acccagctcc tgaggcgact gcaccagtgg ataagctcgg     6240

agtgtaccac tccatgctcc ggttcctggc tgagggacat ctgggactgg atatgcgagg     6300

tgctgagcga ctttaagacc tggctgaaag ccaagctcat gccgcaactg cctgggattc     6360

cctttgtgtc ctgccagcgt gggtataagg gggtctggcg aggggacggc atcatgcaca     6420

ctcgctgcca ctgtggagct gagataactg gacatgtcaa aaacgggacg atgaggatcg     6480

ttggtcctaa gacttgcagg aacatgtgga gtgggacttt ccccattaac gcctacacca     6540

cgggcccctg tactcccctt cctgcgccga actatacgtt cgcgctgtgg agggtgtctg     6600

cagaggaata cgtggagata aggcaggtgg gggacttcca ctacgtgacg ggtatgacta     6660

ctgacaacct taaatgcccg tgccaggtcc catcgcccga atttttcaca gaattggacg     6720

gggtgcgcct acataggttt gcgccccctt gcaagcccct gctgcgggag gaggtgtcat     6780

tcagagtggg actccacgag tacccggtgg ggtcgcaatt accttgcgag cccgaaccgg     6840

acgtggccgt gttgacgtcc atgctcactg atccctccca tataacagca gaggcggccg     6900

ggagaaggtt ggcgagggga tcacccccct ctatggccag ctcctcggct agccaactgt     6960

ccgctccatc tctcagggca acttgcacta ccaaccatga ctcccctgat gctgagctca     7020

tagaggccaa cctcctatgg aggcaggaga tgggcggcaa catcaccagg gttgagtcag     7080

agaacaaagt ggtgattctg gactccttcg atccgcttgt ggcagaggag gatgagcggg     7140

aggtctccgt gcccgcagag atactgcgga agtctcggaa attcacccca gccctaccca     7200

tttgggcgcg gccggactat aaccccccgc tggtggagcc gtggaaaaag cctgactacg     7260

aaccacctgt ggtccatggc tgcccgcttc cacctccaca gtcccctcct gtgcctccac     7320

ctcggaagaa gcggacggtg atcctcaccg aatcaaccct acctactgcc ttggccgagc     7380

ttgccaccaa aagttttggc agctcctcaa cttccggcat tacgggcgac gacacgacaa     7440

catcccctga gcccgcctcc tctagctgcc ctcccgactc cgacgctgag tcctattctt     7500

ccatgccccc tctggagggg gagcctgggg atccggatct cagcgacggg tcatggtcga     7560

cggtcagtag tgaggccgac aaggaggatg tcgtgtgctg ctcaatgtct tatacctgga     7620

caggcgcact cgtcaccccg tgcgccgcgg aagaacaaaa actgcccatc aacgcactaa     7680

gcaactcgtt gctgcgtcat cacaatctgg tgtattccac cacctcacgc agtgcttgcc     7740

aaaggcagaa gaaagtcaca tttgacagac tgcaagtcct ggacagccat taccaggacg     7800

tgctcaagga ggttaaggca gcggcgtcaa aagtgaaggc taacttgcta tccgtagagg     7860

aagcttgcag cctgacgccc ccacactcag ccaaatccaa gtttggctat ggggcaaaag     7920

acgtccgttg ccatgccaga aaggccgtaa accacatcaa ctccgtgtgg aaagaccttc     7980

tggaagacag tgtaacacca atagacacta ccatcatggc taagaacgag gttttctgcg     8040

ttcagcctga gaaggggggt cgtaagccag ctcgtctcat cgtgttcccc gacctgggtg     8100

tacgcgtgtg cgagaagatg gccttgtacg acgtagtcag caagctcccc ctagccgtga     8160

tgggaagctc ctacggattc caatactcac caggacagcg ggttgaattc ctcgtgcaag     8220

cgtggaagtc caagaagacc ccaatggggt tttcgtatga tacccgctgt tttgactcca     8280

cagtcactga gaatgatatc cgtacggagg aggcaatcta ccaatgttgt gacctggacc     8340

cccaagcccg cgtggccatc aagtccctca ctgagaggct ttatgtcggg ggccctctta     8400

ccaattcaag gggggagaac tgcggctatc gcaggtgccg cgcgagcggc gtactgacga     8460

ccagctgtgg taacaccctc acctgctaca tcaaggcccg agcagcctgt cgagccgcag     8520

ggctccagga ctgcaccatg ctcgtgtgtg gcgacgactt agtcgttatc tgtgagagtg     8580

cgggggtcca ggaggacgcg gcgagcctga gagccttcac ggaggctatg accaggtact     8640

ccgccccccc cggggacccc ccacaaccag aatacgactt ggagctcata acatcatgct     8700

cctccaacgt gtcagtcgcc cacgacggcg ctggaaaaag ggtctactac ctcacccgtg     8760

accctacaac ccccctcgcg cgggccgcgt gggagacagc aagacacact ccagtcaatt     8820

cctggctagg caacataatt atgtttgccc ccacactgtg ggcgaggatg atactgatga     8880

cccatttctt tagcgtcctc atagccaggg atcagcttga acaggccctc gattgcgaga     8940

tctacggggc ctgctactcc atagaaccac tggatctacc tccaatcatt caaagactcc     9000

atggcctcag cgcattttca ctccacagtt actctccagg tgaaatcaat agggtggccg     9060

catgcctcag aaaacttggg gtcccgccct tgcgagcttg gagacaccgg gcccggaatg     9120

tccgcgctag gcttctgtcc agaggaggca gggctgccat ttgtggcaag tacctcttca     9180

actgggcagt aaggacaaag ctcaaactca ctccaatagc ggccgctggc cggctagact     9240

tatctggctg gttcacggct ggctacagcg ggggaggcat ttttcacagc gtgtctcatg     9300

cccggccccg ctggttctgg tcttgcctac tcctgctcgc tgcaggggta ggcatctacc     9360

tcctccccaa ccgatgaagg ttggggtaaa cactccggcc tcttaggcca tttcctgttt     9420

tttttttttt tttttttttt tttttttttt tttttttttt tttctttttc cctctttttc     9480

ttctcttttt ccttctttaa tggtggctcc atcttagccc tagtcacggc tagctgtgaa     9540

aggtccgtga gccgcatgac tgcagagagt gctgatactg gcctctctgc agatcatgt      9599


<210>  144
<211>  9599
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid

<400>  144
gccagccccc tgatgggggc gacactccac catgaatcac tcccctgtga ggaactactg       60

tcttcacgca gaaagcgtct agccatggcg ttagtatgag tgtcgtgcag cctccaggac      120

cccccctccc gggagagcca tagtggtctg cggaaccggt gagtacaccg gaattgccag      180

gacgaccggg tcctttcttg gatcaacccg ctcaatgcct ggagatttgg gcgtgccccc      240

gcaagactgc tagccgagta gtgttgggtc gcgaaaggcc ttgtggtact gcctgatagg      300

gtgcttgcga gtgccccggg aggtctcgta gaccgtgcac catgagcacg aatcctaaac      360

ctcaaagaaa aaccaaacgt aacaccaacc gtcgcccaca ggacgtcaag ttcccgggtg      420

gcggtcagat cgttggtgga gtttacttgt tgccgcgcag gggccctaga ttgggtgtgc      480

gcgcgacgag gaagacttcc gagcggtcgc aacctcgagg tagacgtcag cctatcccca      540

aggcgcgtcg gcccgagggc aggacctggg ctcagcccgg gtacccttgg cccctctatg      600

gcaatgaggg ttgcgggtgg gcgggatggc tcctgtctcc ccgtggctct cggcctagct      660

ggggccccac ggacccccgg cgtaggtcgc gcaatttggg taaggtcatc gataccctta      720

cgtgcggctt cgccgacctc atggggtaca taccgctcgt cggcgcccct cttggaggcg      780

ctgccagggc cctggcgcat ggcgtccggg ttttggaaga cggcgtgaac tatgcaacag      840

ggaaccttcc tggttgctct ttctctattt tccttctggc cctgctctct tgtctgactg      900

gacccgcttc agcctaccaa gtgcgcaact ccacggggct ttaccatgtc accaatgatt      960

gccccaactc gagcattgtg ttcgaggcgg ctgatgccat cctgcacact ccggggtgtg     1020

tcccttgcgt acgcgagggt aacgcctcga ggtgttgggt ggcggtaacc cccacggtgg     1080

ccaccaggga tggcaaactc cccacaacgc agcttcgacg tcacatcgat ctgcttgtcg     1140

ggagcgccac cctctgctcg gccctttacg tgggggacct gtgcgggtct gtctttcttg     1200

ttggtcaact gttcaccttc tctcccaggc gccactggac gacgcaagat tgcaattgtt     1260

ctatctaccc cggccatatt tcaggtcacc gtatggcatg ggatatgatg atgaactggt     1320

cccctacggc ggcgttgttg gtagctcagc tgctccggat cccacaagcc atcctggaca     1380

tgatcgctgg tgctcactgg ggagtcctgg cgggcatggc gtatttctcc atggtgggga     1440

actgggcgaa ggttctggta gtgctgctgc tatttgccgg cgtcgacgcg gaaacctacg     1500

tcaccggggg aagtgccgcc cgtactacgg ctggacttgc tagtcttttc tcaccaggcg     1560

ccaagcagaa catccagctg gtcaacacca acggcagttg gcacatcaat agcacggcct     1620

tgaactgcaa tgacagcctc aacaccggct ggatagcagg acttttctat caccacaaat     1680

tcaactcttc gggctgttcc gagaggttag ccagctgccg accccttacc gattttgccc     1740

agggctgggg ccctatcagt cacgccgacg gaagtggccc cgaccaacgc ccctactgct     1800

ggcactaccc tccaaaacct tgtggtattg tgcccgcaaa gagcgtgtgt ggcccggtat     1860

attgtttcac tcccagtccc gtggtggtgg gaacgaccga caggtcgggc gcgcctacct     1920

acagctgggg tgcaaatgac acggacgtct tcgtccttaa caacaccagg ccaccgctgg     1980

gcaattggtt cggttgcacc tggatgaact caactggatt caccaaagtg tgcggagcgc     2040

ccccttgcgt catcggaggg gtgggcaaca acaccttgcg ctgccccact gattgtttcc     2100

gcaagcatcc ggaagccaca tactctcggt gcggctccgg tccctggatt acgcccaggt     2160

gcctggtcga ctacccgtat aggctttggc attatccttg taccatcaac tacaccgtgt     2220

ttaaagtcag gatgtacgtg ggaggggtcg agcacaggct ggaagctgcc tgcaactgga     2280

cgcggggcga ccgttgtaat ctggatgaca gggacaggtc cgagctcagc ccgctgctgc     2340

tgtccactac gcagtggcag gtcctcccgt gttccttcac gaccctgcca gccttgtcca     2400

ccggcctcat ccacctccac caaaacatcg tggacgtgca atacttgtac ggggtgggat     2460

caagcatcgc gtcctgggcc atcaagtggg aatacgtcgt tctcttgttc cttctgcttg     2520

cagacgcgcg cgtctgctcc tgcttgtgga tgatgttact catatcccaa gtggaggcgg     2580

ctttggagaa cctcgtagta ctcaatgcag catccctggc cgggacacac ggtcttgtat     2640

ccttcctcgt gttcttctgc tttgcatggt atctgaaggg taagtgggtg cccggagcgg     2700

tctacgccct ctacgggatg tggcctctcc tcttgctcct gttagcgttg ccccagcggg     2760

catacgcact ggacacggag gtggccgcgt cgtgtggcgg cgttgttctt gtcgggttaa     2820

tggcgctgac tctgtcacca tattacaagc gctatatcag ctggtgcttg tggtggcttc     2880

agtatttcct gaccagaata gaagcgcaac tgcacgtgtg gattccccct ctcaacgtcc     2940

ggggggggcg cgatgccgtc atcttactca tgtgtgttgt gcacccggct ctggtatttg     3000

acatcaccaa gctactgctg gctgccttcg ggcccctttg gattcttcaa gccagtttgc     3060

ttaaggtacc ctacttcgtg cgcgttcaag gccttctccg gatctgcgcg ctagcgcgga     3120

agatggctgg aggccattac gtgcaaatgg ccatcatcaa gttaggggcg cttactggca     3180

cttatgttta caaccatctc accccccttc gggactgggc gcacaacggc ctgcgagatc     3240

tggccgtggc tgtggagcca gtcgtcttct cccgaatgga gaccaagctt atcacctggg     3300

gggcagacac cgccgcgtgc ggtgacatca tcaacggctt gcccgtctcc gcccggaggg     3360

gccgggagat actgctcggg ccagccgatg gaatggtctc caaggggtgg agattgctgg     3420

cgcccatcac ggcgtacgcc cagcaaacga ggggcctcct agggtgtata atcaccagtc     3480

tgaccggccg ggacaaaaac caagtggagg gtgagatcca gattgtgtca actgctgccc     3540

aaaccttcct ggcaacgtgc atcaacgggg tttgctggac cgtctaccac ggggccggaa     3600

cgaggaccat cgcatcaccc aagggtccgg ttatccaaat gtataccaat gtggacaaag     3660

accttgtggg ctggcccgct cctcaaggtg cccgctcact gacaccctgt acctgcggct     3720

cctcggacct ttacctggtc acgaggcacg ccgatgtcat tcccgtgcgc cggcggggtg     3780

atagcagggg cagcctgctt tcgccccggc ccatttccta cttgaaaggc tcctcggggg     3840

gtccgctgct gtgccccgcg ggacacgccg taggcttatt cagggccgcg gtgtgcaccc     3900

gtggagtggc taaggcggtg gacttcatcc ctgtggagaa cctagagaca accatgaggt     3960

ccccggtgtt cacggacaac tcctctccac cagcagtgcc ccagagcttc caggtgggcc     4020

acctgcatgc tcccaccggc agcggcaaaa gcaccaaggt cccggctgca tacgcagctc     4080

agggctataa ggtgctagtg ctcaacccct ctgtcgctgc aacactgggc tttggtgctt     4140

acatgtccaa ggcccatggg gtcgatccta atatcaggac cggggtgaga acaattacca     4200

ctggcagccc catcacgtac tccacctacg gcaagttcct tgccgacggc gggtgttcag     4260

ggggtgctta tgacataata atttgtgacg agtgccactc cacggatgcc acatccatct     4320

tgggcatcgg caccgttctt gaccaagcag agaccgcggg ggcgagactg gttgtgctcg     4380

ccaccgctac ccctccgggc tccatcaccg tgccccatcc taacatcgag gaggttgctc     4440

tgtccactac cggagagatc cctttttacg gcaaggctat ccccctcgag gcgatcaagg     4500

gggggagaca tctcatcttc tgtcactcaa agaagaagtg cgacgagctc gccgcaaagc     4560

tggtcgcatt gggcatcaat gccgtggcct actaccgcgg tcttgacgtg tctgtcatcc     4620

caaccagcgg cgatgttgtc gtcgtggcga ccgatgctct tatgactggc tataccggcg     4680

actttgactc ggtgatagac tgcaacacgt gtgtcaccca gacagtcgac ctcagccttg     4740

accctacctt caccattgag acgaccacgc tcccccagga cgctgtctcc cgcacacaac     4800

gccggggcag gactggcagg gggaagccag gcatctacag attcgtggca ctgggggagc     4860

gcccctccgg catgttcgac tcgtccgttc tctgtgagtg ctatgacgcg ggctgtgctt     4920

ggtatgagct cacgcccgcc gagactacag ttagactacg agcgtacatg aacaccccgg     4980

ggctccctgt gtgccaggac catcttgaat tttgggaggg cgtctttaca ggcctcaccc     5040

atatagatgc ccatttccta tctcagacaa agcagagcgg ggaaaacttt ccttacctgg     5100

tagcatacca agcaaccgtg tgcgctaggg ctcaagcccc tcccccatcg tgggaccaga     5160

tgtggaagtg tttgactcgc ctcaagccca ccctccatgg gccaacaccc ttgctataca     5220

gactgggcgc tgttcagaat gaagtcaccc tgacgcaccc aatcaccaaa tacatcatga     5280

catgcatgtc ggccgacctg gaggtcgtca cgagcacctg ggtgctcgtc ggcggcgtcc     5340

tggccgcttt ggcctcgtat tgcctgtcaa caggctgcgt ggtcatagtg ggcaggattg     5400

tcctgtctgg gaagccggca attatacctg acagggaagt tctctaccgg gagttcgatg     5460

agatggaaga gtgctctcag cacttaccgt acatcgagca agggatgatg ctcgccgagc     5520

agttcaagca gaaggccctc ggcctcctgc agaccgcgtc ccgtcaggca gaggttgtcg     5580

cccctgctgt ccagaccaac tggcaaaaac tcgaggcctt ctgggcgaag catatgtgga     5640

acttcatcag tgggatacac tacttggcgg gcttgtcaac gttgcctggt aaccccgcca     5700

ttgcttcatt gatggctttt acagctgctg tcaccagccc actaaccact agccaaaccc     5760

tcctcttcaa catactgggg gggtgggtgg ctgcccagct tgccgccccc ggtgccgcca     5820

ccgcctttgt gggcgctggc ttagccggcg ccgcaatcgg cagtgttgga ctggggaagg     5880

tcctcgtgga cattctagca gggtatggcg cgggcgtggc gggagctctt gtagcattca     5940

agatcatgag cggtgaggtc ccctccacgg aggacctagt caacctgctg cccgccatcc     6000

tctcgcctgg agcccttgta gtcggtgtgg tctgcgcagc aatactgcgc cggcacgtcg     6060

gcccgggcga gggggcagtg caatggatga accggctaat cgccttcgcc tcccggggga     6120

gccatgtttc ccccacgcac tatgtgccgg agagcgatgc agctgcccgc gtcactacca     6180

tactcagcag cctcactgta acccagctcc tgaggcgact gcaccagtgg ataagctcgg     6240

agtgtaccac tccatgctcc ggttcctggc tgagggacat ctgggactgg atatgcgagg     6300

tgctgagcga ctttaagacc tggctgaaag ccaagctcat gccgcaactg cctgggattc     6360

cctttgtgtc ctgccagcgt gggtataagg gggtctggcg aggggacggc atcatgcaca     6420

ctcgctgcca ctgtggagct gagataactg gacatgtcaa aaacgggacg atgaggatcg     6480

ttggtcctaa gacttgcagg aacatgtgga gtgggacttt ccccattaac gcctacacca     6540

cgggcccctg tactcccctt cctgcgccga actatacgtt cgcgctgtgg agggtgtctg     6600

cagaggaata cgtggagata aggcaggtgg gggacttcca ctacgtgacg ggtatgacta     6660

ctgacaacct taaatgcccg tgccaggtcc catcgcccga atttttcaca gaattggacg     6720

gggtgcgcct acataggttt gcgccccctt gcaagcccct gctgcgggag gaggtgtcat     6780

tcagagtggg actccacgag tacccggtgg ggtcgcaatt accttgcgag cccgaaccgg     6840

acgtggccgt gttgacgtcc atgctcactg atccctccca tataacagca gaggcggccg     6900

ggagaaggtt ggcgagggga tcacccccct ctatggccag ctcctcggct agccaactgt     6960

ccgctccatc tctcagggca acttgcacta ccaaccatga ctcccctgat gctgagctca     7020

tagaggccaa cctcctatgg aggcaggaga tgggcggcaa catcaccagg gttgagtcag     7080

agaacaaagt ggtgattctg gactccttcg atccgcttgt ggcagaggag gatgagcggg     7140

aggtctccgt gcccgcagag atactgcgga agtctcggaa attcacccca gccctaccca     7200

tttgggcgcg gccggactat aaccccccgc tggtggagcc gtggaaaaag cctgactacg     7260

aaccacctgt ggtccatggc tgcccgcttc cacctccaca gtcccctcct gtgcctccac     7320

ctcggaagaa gcggacggtg atcctcaccg aatcaaccct acctactgcc ttggccgagc     7380

ttgccaccaa aagttttggc agctcctcaa cttccggcat tacgggcgac gacacgacaa     7440

catcccctga gcccgcctcc tctagctgcc ctcccgactc cgacgctgag tcctattctt     7500

ccatgccccc tctggagggg gagcctgggg atccggatct cagcgacggg tcatggtcga     7560

cggtcagtag tgaggccgac aaggaggatg tcgtgtgctg ctcaatgtct tatacctgga     7620

caggcgcact cgtcaccccg tgcgccgcgg aagaacaaaa actgcccatc aacgcactaa     7680

gcaactcgtt gctgcgtcat cacaatctgg tgtattccac cacctcacgc agtgcttgcc     7740

aaaggcagaa gaaagtcaca tttgacagac tgcaagtcct ggacagccat taccaggacg     7800

tgctcaagga ggttaaggca gcggcgtcaa aagtgaaggc taacttgcta tccgtagagg     7860

aagcttgcag cctgacgccc ccacactcag ccaaatccaa gtttggctat ggggcaaaag     7920

acgtccgttg ccatgccaga aaggccgtaa accacatcaa ctccgtgtgg aaagaccttc     7980

tggaagacag tgtaacacca atagacacta ccatcatggc taagaacgag gttttctgcg     8040

ttcagcctga gaaggggggt cgtaagccag ctcgtctcat cgtgttcccc gacctgggtg     8100

tacgcgtgtg cgagaagatg gccttgtacg acgtagtcag caagctcccc ctagccgtga     8160

tgggaagctc ctacggattc caatactcac caggacagcg ggttgaattc ctcgtgcaag     8220

cgtggaagtc caagaagacc ccaatggggt tttcgtatga tacccgctgt tttgactcca     8280

cagtcactga gaatgatatc cgtacggagg aggcaatcta ccaatgttgt gacctggacc     8340

cccaagcccg cgtggccatc aagtccctca ctgagaggct ttatgtcggg ggccctctta     8400

ccaattcaag gggggagaac tgcggctatc gcaggtgccg cgcgagcggc gtactgacga     8460

ccagctgtgg taacaccctc acctgctaca tcaaggcccg agcagcctgt cgagccgcag     8520

ggctccagga ctgcaccatg ctcgtgtgtg gcgacgactt agtcgttatc tgtgagagtg     8580

cgggggtcca ggaggacgcg gcgagcctga gagccttcac ggaggctatg accaggtact     8640

ccgccccccc cggggacccc ccacaaccag aatacgactt ggagctcata acatcatgct     8700

cctccaacgt gtcagtcgcc cacgacggcg ctggaaaaag ggtctactac ctcacccgtg     8760

accctacaac ccccctcgcg cgggccgcgt gggagacagc aagacacact ccagtcaatt     8820

cctggctagg caacataatt atgtttgccc ccacactgtg ggcgaggatg atactgatga     8880

cccatttctt tagcgtcctc atagccaggg atcagcttga acaggccctc gattgcgaga     8940

tctacggggc ctgctactcc atagaaccac tggatctacc tccaatcatt caaagactcc     9000

atggcctcag cgcattttca ctccacagtt actctccagg tgaaatcaat agggtggccg     9060

catgcctcag aaaacttggg gtcccgccct tgcgagcttg gagacaccgg gcccggaatg     9120

tccgcgctag gcttctgtcc agaggaggca gggctgccat ttgtggcaag tacctcttca     9180

actgggcagt aaggacaaag ctcaaactca ctccaatagc ggccgctggc cggctagact     9240

tatctggctg gttcacggct ggctacagcg ggggaggcat ttttcacagc gtgtctcatg     9300

cccggccccg ctggttctgg tcttgcctac tcctgctcgc tgcaggggta ggcatctacc     9360

tcctccccaa ccgatgaagg ttggggtaaa cactccggcc tcttaggcca tttcctgttt     9420

tttttttttt tttttttttt tttttttttt tttttttttt tttctttttc cctctttttc     9480

ttctcttttt ccttctttaa tggtggctcc atcttagccc tagtcacggc tagctgtgaa     9540

aggtccgtga gccgcatgac tgcagagagt gctgatactg gcctctctgc agatcatgt      9599


<210>  145
<211>  9599
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid

<400>  145
gccagccccc tgatgggggc gacactccac catgaatcac tcccctgtga ggaactactg       60

tcttcacgca gaaagcgtct agccatggcg ttagtatgag tgtcgtgcag cctccaggac      120

cccccctccc gggagagcca tagtggtctg cggaaccggt gagtacaccg gaattgccag      180

gacgaccggg tcctttcttg gatcaacccg ctcaatgcct ggagatttgg gcgtgccccc      240

gcaagactgc tagccgagta gtgttgggtc gcgaaaggcc ttgtggtact gcctgatagg      300

gtgcttgcga gtgccccggg aggtctcgta gaccgtgcac catgagcacg aatcctaaac      360

ctcaaagaaa aaccaaacgt aacaccaacc gtcgcccaca ggacgtcaag ttcccgggtg      420

gcggtcagat cgttggtgga gtttacttgt tgccgcgcag gggccctaga ttgggtgtgc      480

gcgcgacgag gaagacttcc gagcggtcgc aacctcgagg tagacgtcag cctatcccca      540

aggcgcgtcg gcccgagggc aggacctggg ctcagcccgg gtacccttgg cccctctatg      600

gcaatgaggg ttgcgggtgg gcgggatggc tcctgtctcc ccgtggctct cggcctagct      660

ggggccccac ggacccccgg cgtaggtcgc gcaatttggg taaggtcatc gataccctta      720

cgtgcggctt cgccgacctc atggggtaca taccgctcgt cggcgcccct cttggaggcg      780

ctgccagggc cctggcgcat ggcgtccggg ttttggaaga cggcgtgaac tatgcaacag      840

ggaaccttcc tggttgctct ttctctattt tccttctggc cctgctctct tgtctgactg      900

gacccgcttc agcctaccaa gtgcgcaact ccacggggct ttaccatgtc accaatgatt      960

gccccaactc gagcattgtg ttcgaggcgg ctgatgccat cctgcacact ccggggtgtg     1020

tcccttgcgt acgcgagggt aacgcctcga ggtgttgggt ggcggtaacc cccacggtgg     1080

ccaccaggga tggcaaactc cccacaacgc agcttcgacg tcacatcgat ctgcttgtcg     1140

ggagcgccac cctctgctcg gccctttacg tgggggacct gtgcgggtct gtctttcttg     1200

ttggtcaact gttcaccttc tctcccaggc gccactggac gacgcaagat tgcaattgtt     1260

ctatctaccc cggccatatt tcaggtcacc gtatggcatg ggatatgatg atgaactggt     1320

cccctacggc ggcgttgttg gtagctcagc tgctccggat cccacaagcc atcctggaca     1380

tgatcgctgg tgctcactgg ggagtcctgg cgggcatggc gtatttctcc atggtgggga     1440

actgggcgaa ggttctggta gtgctgctgc tatttgccgg cgtcgacgcg gaaacctacg     1500

tcaccggggg aagtgccgcc cgtactacgg ctggacttgc tagtcttttc tcaccaggcg     1560

ccaagcagaa catccagctg gtcaacacca acggcagttg gcacatcaat agcacggcct     1620

tgaactgcaa tgacagcctc aacaccggct ggatagcagg acttttctat caccacaaat     1680

tcaactcttc gggctgttcc gagaggttag ccagctgccg accccttacc gattttgccc     1740

agggctgggg ccctatcagt cacgccgacg gaagtggccc cgaccaacgc ccctactgct     1800

ggcactaccc tccaaaacct tgtggtattg tgcccgcaaa gagcgtgtgt ggcccggtat     1860

attgtttcac tcccagtccc gtggtggtgg gaacgaccga caggtcgggc gcgcctacct     1920

acagctgggg tgcaaatgac acggacgtct tcgtccttaa caacaccagg ccaccgctgg     1980

gcaattggtt cggttgcacc tggatgaact caactggatt caccaaagtg tgcggagcgc     2040

ccccttgcgt catcggaggg gtgggcaaca acaccttgcg ctgccccact gattgtttcc     2100

gcaagcatcc ggaagccaca tactctcggt gcggctccgg tccctggatt acgcccaggt     2160

gcctggtcga ctacccgtat aggctttggc attatccttg taccatcaac tacaccgtgt     2220

ttaaagtcag gatgtacgtg ggaggggtcg agcacaggct ggaagctgcc tgcaactgga     2280

cgcggggcga ccgttgtaat ctggatgaca gggacaggtc cgagctcagc ccgctgctgc     2340

tgtccactac gcagtggcag gtcctcccgt gttccttcac gaccctgcca gccttgtcca     2400

ccggcctcat ccacctccac caaaacatcg tggacgtgca atacttgtac ggggtgggat     2460

caagcatcgc gtcctgggcc atcaagtggg aatacgtcgt tctcttgttc cttctgcttg     2520

cagacgcgcg cgtctgctcc tgcttgtgga tgatgttact catatcccaa gtggaggcgg     2580

ctttggagaa cctcgtagta ctcaatgcag catccctggc cgggacacac ggtcttgtat     2640

ccttcctcgt gttcttctgc tttgcatggt atctgaaggg taagtgggtg cccggagcgg     2700

tctacgccct ctacgggatg tggcctctcc tcttgctcct gttagcgttg ccccagcggg     2760

catacgcact ggacacggag gtggccgcgt cgtgtggcgg cgttgttctt gtcgggttaa     2820

tggcgctgac tctgtcacca tattacaagc gctatatcag ctggtgcttg tggtggcttc     2880

agtatttcct gaccagaata gaagcgcaac tgcacgtgtg gattccccct ctcaacgtcc     2940

ggggggggcg cgatgccgtc atcttactca tgtgtgttgt gcacccggct ctggtatttg     3000

acatcaccaa gctactgctg gctgccttcg ggcccctttg gattcttcaa gccagtttgc     3060

ttaaggtacc ctacttcgtg cgcgttcaag gccttctccg gatctgcgcg ctagcgcgga     3120

agatggctgg aggccattac gtgcaaatgg ccatcatcaa gttaggggcg cttactggca     3180

cttatgttta caaccatctc accccccttc gggactgggc gcacaacggc ctgcgagatc     3240

tggccgtggc tgtggagcca gtcgtcttct cccgaatgga gaccaagctt atcacctggg     3300

gggcagacac cgccgcgtgc ggtgacatca tcaacggctt gcccgtctcc gcccggaggg     3360

gccgggagat actgctcggg ccagccgatg gaatggtctc caaggggtgg agattgctgg     3420

cgcccatcac ggcgtacgcc cagcaaacga ggggcctcct agggtgtata atcaccagtc     3480

tgaccggccg ggacaaaaac caagtggagg gtgagatcca gattgtgtca actgctgccc     3540

aaaccttcct ggcaacgtgc atcaacgggg tttgctggac cgtctaccac ggggccggaa     3600

cgaggaccat cgcatcaccc aagggtccgg ttatccaaat gtataccaat gtggacaaag     3660

accttgtggg ctggcccgct cctcaaggtg cccgctcact gacaccctgt acctgcggct     3720

cctcggacct ttacctggtc acgaggcacg ccgatgtcat tcccgtgcgc cggcggggtg     3780

atagcagggg cagcctgctt tcgccccggc ccatttccta cttgaaaggc tcctcggggg     3840

gtccgctgct gtgccccgcg ggacacgccg taggcttatt cagggccgcg gtgtgcaccc     3900

gtggagtggc taaggcggtg gacttcatcc ctgtggagaa cctagagaca accatgaggt     3960

ccccggtgtt cacggacaac tcctctccac cagcagtgcc ccagagcttc caggtgggcc     4020

acctgcatgc tcccaccggc agcggcaaaa gcaccaaggt cccggctgca tacgcagctc     4080

agggctataa ggtgctagtg ctcaacccct ctgtcgctgc aacactgggc tttggtgctt     4140

acatgtccaa ggcccatggg gtcgatccta atatcaggac cggggtgaga acaattacca     4200

ctggcagccc catcacgtac tccacctacg gcaagttcct tgccgacggc gggtgttcag     4260

ggggtgctta tgacataata atttgtgacg agtgccactc cacggatgcc acatccatct     4320

tgggcatcgg caccgttctt gaccaagcag agaccgcggg ggcgagactg gttgtgctcg     4380

ccaccgctac ccctccgggc tccatcaccg tgccccatcc taacatcgag gaggttgctc     4440

tgtccactac cggagagatc cctttttacg gcaaggctat ccccctcgag gcgatcaagg     4500

gggggagaca tctcatcttc tgtcactcaa agaagaagtg cgacgagctc gccgcaaagc     4560

tggtcgcatt gggcatcaat gccgtggcct actaccgcgg tcttgacgtg tctgtcatcc     4620

caaccagcgg cgatgttgtc gtcgtggcga ccgatgctct tatgactggc tataccggcg     4680

actttgactc ggtgatagac tgcaacacgt gtgtcaccca gacagtcgac ctcagccttg     4740

accctacctt caccattgag acgaccacgc tcccccagga cgctgtctcc cgcacacaac     4800

gccggggcag gactggcagg gggaagccag gcatctacag attcgtggca ctgggggagc     4860

gcccctccgg catgttcgac tcgtccgttc tctgtgagtg ctatgacgcg ggctgtgctt     4920

ggtatgagct cacgcccgcc gagactacag ttagactacg agcgtacatg aacaccccgg     4980

ggctccctgt gtgccaggac catcttgaat tttgggaggg cgtctttaca ggcctcaccc     5040

atatagatgc ccatttccta tctcagacaa agcagagcgg ggaaaacttt ccttacctgg     5100

tagcatacca agcaaccgtg tgcgctaggg ctcaagcccc tcccccatcg tgggaccaga     5160

tgtggaagtg tttgactcgc ctcaagccca ccctccatgg gccaacaccc ttgctataca     5220

gactgggcgc tgttcagaat gaagtcaccc tgacgcaccc aatcaccaaa tacatcatga     5280

catgcatgtc ggccgacctg gaggtcgtca cgagcacctg ggtgctcgtc ggcggcgtcc     5340

tggccgcttt ggcctcgtat tgcctgtcaa caggctgcgt ggtcatagtg ggcaggattg     5400

tcctgtctgg gaagccggca attatacctg acagggaagt tctctaccgg gagttcgatg     5460

agatggaaga gtgctctcag cacttaccgt acatcgagca agggatgatg ctcgccgagc     5520

agttcaagca gaaggccctc ggcctcctgc agaccgcgtc ccgtcaggca gaggttgtcg     5580

cccctgctgt ccagaccaac tggcaaaaac tcgaggcctt ctgggcgaag catatgtgga     5640

acttcatcag tgggatacac tacttggcgg gcttgtcaac gttgcctggt aaccccgcca     5700

ttgcttcatt gatggctttt acagctgctg tcaccagccc actaaccact agccaaaccc     5760

tcctcttcaa catactgggg gggtgggtgg ctgcccagct tgccgccccc ggtgccgcca     5820

ccgcctttgt gggcgctggc ttagccggcg ccgcaatcgg cagtgttgga ctggggaagg     5880

tcctcgtgga cattctagca gggtatggcg cgggcgtggc gggagctctt gtagcattca     5940

agatcatgag cggtgaggtc ccctccacgg aggacctagt caacctgctg cccgccatcc     6000

tctcgcctgg agcccttgta gtcggtgtgg tctgcgcagc aatactgcgc cggcacgtcg     6060

gcccgggcga gggggcagtg caatggatga accggctaat cgccttcgcc tcccggggga     6120

cccatgtttc ccccacgcac tatgtgccgg agagcgatgc agctgcccgc gtcactacca     6180

tactcagcag cctcactgta acccagctcc tgaggcgact gcaccagtgg ataagctcgg     6240

agtgtaccac tccatgctcc ggttcctggc tgagggacat ctgggactgg atatgcgagg     6300

tgctgagcga ctttaagacc tggctgaaag ccaagctcat gccgcaactg cctgggattc     6360

cctttgtgtc ctgccagcgt gggtataagg gggtctggcg aggggacggc atcatgcaca     6420

ctcgctgcca ctgtggagct gagataactg gacatgtcaa aaacgggacg atgaggatcg     6480

ttggtcctaa gacttgcagg aacatgtgga gtgggacttt ccccattaac gcctacacca     6540

cgggcccctg tactcccctt cctgcgccga actatacgtt cgcgctgtgg agggtgtctg     6600

cagaggaata cgtggagata aggcaggtgg gggacttcca ctacgtgacg ggtatgacta     6660

ctgacaacct taaatgcccg tgccaggtcc catcgcccga atttttcaca gaattggacg     6720

gggtgcgcct acataggttt gcgccccctt gcaagcccct gctgcgggag gaggtgtcat     6780

tcagagtggg actccacgag tacccggtgg ggtcgcaatt accttgcgag cccgaaccgg     6840

acgtggccgt gttgacgtcc atgctcactg atccctccca tataacagca gaggcggccg     6900

ggagaaggtt ggcgagggga tcacccccct ctatggccag ctcctcggct agccaactgt     6960

ccgctccatc tctcagggca acttgcacta ccaaccatga ctcccctgat gctgagctca     7020

tagaggccaa cctcctatgg aggcaggaga tgggcggcaa catcaccagg gttgagtcag     7080

agaacaaagt ggtgattctg gactccttcg atccgcttgt ggcagaggag gatgagcggg     7140

aggtctccgt gcccgcagag atactgcgga agtctcggaa attcacccca gccctaccca     7200

tttgggcgcg gccggactat aaccccccgc tggtggagcc gtggaaaaag cctgactacg     7260

aaccacctgt ggtccatggc tgcccgcttc cacctccaca gtcccctcct gtgcctccac     7320

ctcggaagaa gcggacggtg atcctcaccg aatcaaccct acctactgcc ttggccgagc     7380

ttgccaccaa aagttttggc agctcctcaa cttccggcat tacgggcgac gacacgacaa     7440

catcccctga gcccgcctcc tctagctgcc ctcccgactc cgacgctgag tcctattctt     7500

ccatgccccc tctggagggg gagcctgggg atccggatct cagcgacggg tcatggtcga     7560

cggtcagtag tgaggccgac aaggaggatg tcgtgtgctg ctcaatgtct tatacctgga     7620

caggcgcact cgtcaccccg tgcgccgcgg aagaacaaaa actgcccatc aacgcactaa     7680

gcaactcgtt gctgcgtcat cacaatctgg tgtattccac cacctcacgc agtgcttgcc     7740

aaaggcagaa gaaagtcaca tttgacagac tgcaagtcct ggacagccat taccaggacg     7800

tgctcaagga ggttaaggca gcggcgtcaa aagtgaaggc taacttgcta tccgtagagg     7860

aagcttgcag cctgacgccc ccacactcag ccaaatccaa gtttggctat ggggcaaaag     7920

acgtccgttg ccatgccaga aaggccgtaa accacatcaa ctccgtgtgg aaagaccttc     7980

tggaagacag tgtaacacca atagacacta ccatcatggc taagaacgag gttttctgcg     8040

ttcagcctga gaaggggggt cgtaagccag ctcgtctcat cgtgttcccc gacctgggtg     8100

tacgcgtgtg cgagaagatg gccttgtacg acgtagtcag caagctcccc ctagccgtga     8160

tgggaagctc ctacggattc caatactcac caggacagcg ggttgaattc ctcgtgcaag     8220

cgtggaagtc caagaagacc ccaatggggt tttcgtatga tacccgctgt tttgactcca     8280

cagtcactga gaatgatatc cgtacggagg aggcaatcta ccaatgttgt gacctggacc     8340

cccaagcccg cgtggccatc aagtccctca ctgagaggct ttatgtcggg ggccctctta     8400

ccaattcaag gggggagaac tgcggctatc gcaggtgccg cgcgagcggc gtactgacga     8460

ccagctgtgg taacaccctc acctgctaca tcaaggcccg agcagcctgt cgagccgcag     8520

ggctccagga ctgcaccatg ctcgtgtgtg gcgacgactt agtcgttatc tgtgagagtg     8580

cgggggtcca ggaggacgcg gcgagcctga gagccttcac ggaggctatg accaggtact     8640

ccgccccccc cggggacccc ccacaaccag aatacgactt ggagctcata acatcatgct     8700

cctccaacgt gtcagtcgcc cacgacggcg ctggaaaaag ggtctactac ctcacccgtg     8760

accctacaac ccccctcgcg cgggccgcgt gggagacagc aagacacact ccagtcaatt     8820

cctggctagg caacataatt atgtttgccc ccacactgtg ggcgaggatg atactgatga     8880

cccatttctt tagcgtcctc atagccaggg atcagcttga acaggccctc gattgcgaga     8940

tctacggggc ctgctactcc atagaaccac tggatctacc tccaatcatt caaagactcc     9000

atggcctcag cgcattttca ctccacagtt actctccagg tgaaatcaat agggtggccg     9060

catgcctcag aaaacttggg gtcccgccct tgcgagcttg gagacaccgg gcccggaatg     9120

tccgcgctag gcttctgtcc agaggaggca gggctgccat ttgtggcaag tacctcttca     9180

actgggcagt aaggacaaag ctcaaactca ctccaatagc ggccgctggc cggctagact     9240

tatctggctg gttcacggct ggctacagcg ggggaggcat ttttcacagc gtgtctcatg     9300

cccggccccg ctggttctgg tcttgcctac tcctgctcgc tgcaggggta ggcatctacc     9360

tcctccccaa ccgatgaagg ttggggtaaa cactccggcc tcttaggcca tttcctgttt     9420

tttttttttt tttttttttt tttttttttt tttttttttt tttctttttc cctctttttc     9480

ttctcttttt ccttctttaa tggtggctcc atcttagccc tagtcacggc tagctgtgaa     9540

aggtccgtga gccgcatgac tgcagagagt gctgatactg gcctctctgc agatcatgt      9599


<210>  146
<211>  3011
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  plasmid

<400>  146

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Gly Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Thr Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Phe Glu Ala Ala Asp Ala Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Val Thr Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Thr Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Ser Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Ala Leu Leu Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Met Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr Tyr Val Thr Gly Gly Ser Ala Ala Arg Thr Thr Ala Gly Leu Ala 
385                 390                 395                 400 


Ser Leu Phe Ser Pro Gly Ala Lys Gln Asn Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Asn Thr Gly Trp Ile Ala Gly Leu Phe Tyr His His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Ser Glu Arg Leu Ala Ser Cys Arg Pro Leu Thr Asp 
    450                 455                 460                 


Phe Ala Gln Gly Trp Gly Pro Ile Ser His Ala Asp Gly Ser Gly Pro 
465                 470                 475                 480 


Asp Gln Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Lys Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly Ala Pro Thr Tyr Ser 
        515                 520                 525             


Trp Gly Ala Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu Arg Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Ile Asn Tyr 
    610                 615                 620                 


Thr Val Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Glu Ala Ala Cys Asn Trp Thr Arg Gly Asp Arg Cys Asn Leu Asp Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Ile Ala Ser Trp Ala Ile Lys Trp Glu Tyr Val Val 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Val Glu Ala Ala Leu Glu Asn Leu Val 
            740                 745                 750         


Val Leu Asn Ala Ala Ser Leu Ala Gly Thr His Gly Leu Val Ser Phe 
        755                 760                 765             


Leu Val Phe Phe Cys Phe Ala Trp Tyr Leu Lys Gly Lys Trp Val Pro 
    770                 775                 780                 


Gly Ala Val Tyr Ala Leu Tyr Gly Met Trp Pro Leu Leu Leu Leu Leu 
785                 790                 795                 800 


Leu Ala Leu Pro Gln Arg Ala Tyr Ala Leu Asp Thr Glu Val Ala Ala 
                805                 810                 815     


Ser Cys Gly Gly Val Val Leu Val Gly Leu Met Ala Leu Thr Leu Ser 
            820                 825                 830         


Pro Tyr Tyr Lys Arg Tyr Ile Ser Trp Cys Leu Trp Trp Leu Gln Tyr 
        835                 840                 845             


Phe Leu Thr Arg Ile Glu Ala Gln Leu His Val Trp Ile Pro Pro Leu 
    850                 855                 860                 


Asn Val Arg Gly Gly Arg Asp Ala Val Ile Leu Leu Met Cys Val Val 
865                 870                 875                 880 


His Pro Ala Leu Val Phe Asp Ile Thr Lys Leu Leu Leu Ala Ala Phe 
                885                 890                 895     


Gly Pro Leu Trp Ile Leu Gln Ala Ser Leu Leu Lys Val Pro Tyr Phe 
            900                 905                 910         


Val Arg Val Gln Gly Leu Leu Arg Ile Cys Ala Leu Ala Arg Lys Met 
        915                 920                 925             


Ala Gly Gly His Tyr Val Gln Met Ala Ile Ile Lys Leu Gly Ala Leu 
    930                 935                 940                 


Thr Gly Thr Tyr Val Tyr Asn His Leu Thr Pro Leu Arg Asp Trp Ala 
945                 950                 955                 960 


His Asn Gly Leu Arg Asp Leu Ala Val Ala Val Glu Pro Val Val Phe 
                965                 970                 975     


Ser Arg Met Glu Thr Lys Leu Ile Thr Trp Gly Ala Asp Thr Ala Ala 
            980                 985                 990         


Cys Gly Asp Ile Ile Asn Gly Leu  Pro Val Ser Ala Arg  Arg Gly Arg 
        995                 1000                 1005             


Glu Ile  Leu Leu Gly Pro Ala  Asp Gly Met Val Ser  Lys Gly Trp 
    1010                 1015                 1020             


Arg Leu  Leu Ala Pro Ile Thr  Ala Tyr Ala Gln Gln  Thr Arg Gly 
    1025                 1030                 1035             


Leu Leu  Gly Cys Ile Ile Thr  Ser Leu Thr Gly Arg  Asp Lys Asn 
    1040                 1045                 1050             


Gln Val  Glu Gly Glu Ile Gln  Ile Val Ser Thr Ala  Ala Gln Thr 
    1055                 1060                 1065             


Phe Leu  Ala Thr Cys Ile Asn  Gly Val Cys Trp Thr  Val Tyr His 
    1070                 1075                 1080             


Gly Ala  Gly Thr Arg Thr Ile  Ala Ser Pro Lys Gly  Pro Val Ile 
    1085                 1090                 1095             


Gln Met  Tyr Thr Asn Val Asp  Lys Asp Leu Val Gly  Trp Pro Ala 
    1100                 1105                 1110             


Pro Gln  Gly Ala Arg Ser Leu  Thr Pro Cys Thr Cys  Gly Ser Ser 
    1115                 1120                 1125             


Asp Leu  Tyr Leu Val Thr Arg  His Ala Asp Val Ile  Pro Val Arg 
    1130                 1135                 1140             


Arg Arg  Gly Asp Ser Arg Gly  Ser Leu Leu Ser Pro  Arg Pro Ile 
    1145                 1150                 1155             


Ser Tyr  Leu Lys Gly Ser Ser  Gly Gly Pro Leu Leu  Cys Pro Ala 
    1160                 1165                 1170             


Gly His  Ala Val Gly Leu Phe  Arg Ala Ala Val Cys  Thr Arg Gly 
    1175                 1180                 1185             


Val Ala  Lys Ala Val Asp Phe  Ile Pro Val Glu Asn  Leu Glu Thr 
    1190                 1195                 1200             


Thr Met  Arg Ser Pro Val Phe  Thr Asp Asn Ser Ser  Pro Pro Ala 
    1205                 1210                 1215             


Val Pro  Gln Ser Phe Gln Val  Ala His Leu His Ala  Pro Thr Gly 
    1220                 1225                 1230             


Ser Gly  Lys Ser Thr Lys Val  Pro Ala Ala Tyr Ala  Ala Gln Gly 
    1235                 1240                 1245             


Tyr Lys  Val Leu Val Leu Asn  Pro Ser Val Ala Ala  Thr Leu Gly 
    1250                 1255                 1260             


Phe Gly  Ala Tyr Met Ser Lys  Ala His Gly Val Asp  Pro Asn Ile 
    1265                 1270                 1275             


Arg Thr  Gly Val Arg Thr Ile  Thr Thr Gly Ser Pro  Ile Thr Tyr 
    1280                 1285                 1290             


Ser Thr  Tyr Gly Lys Phe Leu  Ala Asp Gly Gly Cys  Ser Gly Gly 
    1295                 1300                 1305             


Ala Tyr  Asp Ile Ile Ile Cys  Asp Glu Cys His Ser  Thr Asp Ala 
    1310                 1315                 1320             


Thr Ser  Ile Leu Gly Ile Gly  Thr Val Leu Asp Gln  Ala Glu Thr 
    1325                 1330                 1335             


Ala Gly  Ala Arg Leu Val Val  Leu Ala Thr Ala Thr  Pro Pro Gly 
    1340                 1345                 1350             


Ser Ile  Thr Val Pro His Pro  Asn Ile Glu Glu Val  Ala Leu Ser 
    1355                 1360                 1365             


Thr Thr  Gly Glu Ile Pro Phe  Tyr Gly Lys Ala Ile  Pro Leu Glu 
    1370                 1375                 1380             


Ala Ile  Lys Gly Gly Arg His  Leu Ile Phe Cys His  Ser Lys Lys 
    1385                 1390                 1395             


Lys Cys  Asp Glu Leu Ala Ala  Lys Leu Val Ala Leu  Gly Ile Asn 
    1400                 1405                 1410             


Ala Val  Ala Tyr Tyr Arg Gly  Leu Asp Val Ser Val  Ile Pro Thr 
    1415                 1420                 1425             


Ser Gly  Asp Val Val Val Val  Ala Thr Asp Ala Leu  Met Thr Gly 
    1430                 1435                 1440             


Tyr Thr  Gly Asp Phe Asp Ser  Val Ile Asp Cys Asn  Thr Cys Val 
    1445                 1450                 1455             


Thr Gln  Thr Val Asp Phe Ser  Leu Asp Pro Thr Phe  Thr Ile Glu 
    1460                 1465                 1470             


Thr Thr  Thr Leu Pro Gln Asp  Ala Val Ser Arg Thr  Gln Arg Arg 
    1475                 1480                 1485             


Gly Arg  Thr Gly Arg Gly Lys  Pro Gly Ile Tyr Arg  Phe Val Ala 
    1490                 1495                 1500             


Leu Gly  Glu Arg Pro Ser Gly  Met Phe Asp Ser Ser  Val Leu Cys 
    1505                 1510                 1515             


Glu Cys  Tyr Asp Ala Gly Cys  Ala Trp Tyr Glu Leu  Thr Pro Ala 
    1520                 1525                 1530             


Glu Thr  Thr Val Arg Leu Arg  Ala Tyr Met Asn Thr  Pro Gly Leu 
    1535                 1540                 1545             


Pro Val  Cys Gln Asp His Leu  Glu Phe Trp Glu Gly  Val Phe Thr 
    1550                 1555                 1560             


Gly Leu  Thr His Ile Asp Ala  His Phe Leu Ser Gln  Thr Lys Gln 
    1565                 1570                 1575             


Ser Gly  Glu Asn Phe Pro Tyr  Leu Val Ala Tyr Gln  Ala Thr Val 
    1580                 1585                 1590             


Cys Ala  Arg Ala Gln Ala Pro  Pro Pro Ser Trp Asp  Gln Met Trp 
    1595                 1600                 1605             


Lys Cys  Leu Thr Arg Leu Lys  Pro Thr Leu His Gly  Pro Thr Pro 
    1610                 1615                 1620             


Leu Leu  Tyr Arg Leu Gly Ala  Val Gln Asn Glu Val  Thr Leu Thr 
    1625                 1630                 1635             


His Pro  Ile Thr Lys Tyr Ile  Met Thr Cys Met Ser  Ala Asp Leu 
    1640                 1645                 1650             


Glu Val  Val Thr Ser Thr Trp  Val Leu Val Gly Gly  Val Leu Ala 
    1655                 1660                 1665             


Ala Leu  Ala Ala Tyr Cys Leu  Ser Thr Gly Cys Val  Val Ile Val 
    1670                 1675                 1680             


Gly Arg  Ile Val Leu Ser Gly  Lys Pro Ala Ile Ile  Pro Asp Arg 
    1685                 1690                 1695             


Glu Val  Leu Tyr Arg Glu Phe  Asp Glu Met Glu Glu  Cys Ser Gln 
    1700                 1705                 1710             


His Leu  Pro Tyr Ile Glu Gln  Gly Met Met Leu Ala  Glu Gln Phe 
    1715                 1720                 1725             


Lys Gln  Lys Ala Leu Gly Leu  Leu Gln Thr Ala Ser  Arg Gln Ala 
    1730                 1735                 1740             


Glu Val  Val Ala Pro Ala Val  Gln Thr Asn Trp Gln  Lys Leu Glu 
    1745                 1750                 1755             


Ala Phe  Trp Ala Lys His Met  Trp Asn Phe Ile Ser  Gly Ile Gln 
    1760                 1765                 1770             


Tyr Leu  Ala Gly Leu Ser Thr  Leu Pro Gly Asn Pro  Ala Ile Ala 
    1775                 1780                 1785             


Ser Leu  Met Ala Phe Thr Ala  Ala Val Thr Ser Pro  Leu Thr Thr 
    1790                 1795                 1800             


Ser Gln  Thr Leu Leu Phe Asn  Ile Leu Gly Gly Trp  Val Ala Ala 
    1805                 1810                 1815             


Gln Leu  Ala Ala Pro Gly Ala  Ala Thr Ala Phe Val  Gly Ala Gly 
    1820                 1825                 1830             


Leu Ala  Gly Ala Ala Ile Gly  Ser Val Gly Leu Gly  Lys Val Leu 
    1835                 1840                 1845             


Val Asp  Ile Leu Ala Gly Tyr  Gly Ala Gly Val Ala  Gly Ala Leu 
    1850                 1855                 1860             


Val Ala  Phe Lys Ile Met Ser  Gly Glu Val Pro Ser  Thr Glu Asp 
    1865                 1870                 1875             


Leu Val  Asn Leu Leu Pro Ala  Ile Leu Ser Pro Gly  Ala Leu Val 
    1880                 1885                 1890             


Val Gly  Val Val Cys Ala Ala  Ile Leu Arg Arg His  Val Gly Pro 
    1895                 1900                 1905             


Gly Glu  Gly Ala Val Gln Trp  Met Asn Arg Leu Ile  Ala Phe Ala 
    1910                 1915                 1920             


Ser Arg  Gly Asn His Val Ser  Pro Thr His Tyr Val  Pro Glu Ser 
    1925                 1930                 1935             


Asp Ala  Ala Ala Arg Val Thr  Thr Ile Leu Ser Ser  Leu Thr Val 
    1940                 1945                 1950             


Thr Gln  Leu Leu Arg Arg Leu  His Gln Trp Ile Ser  Ser Glu Cys 
    1955                 1960                 1965             


Thr Thr  Pro Cys Ser Gly Ser  Trp Leu Arg Asp Ile  Trp Asp Trp 
    1970                 1975                 1980             


Ile Cys  Glu Val Leu Ser Asp  Phe Lys Thr Trp Leu  Lys Ala Lys 
    1985                 1990                 1995             


Leu Met  Pro Gln Leu Pro Gly  Ile Pro Phe Val Ser  Cys Gln Arg 
    2000                 2005                 2010             


Gly Tyr  Lys Gly Val Trp Arg  Gly Asp Gly Ile Met  His Thr Arg 
    2015                 2020                 2025             


Cys His  Cys Gly Ala Glu Ile  Thr Gly His Val Lys  Asn Gly Thr 
    2030                 2035                 2040             


Met Arg  Ile Val Gly Pro Lys  Thr Cys Arg Asn Met  Trp Ser Gly 
    2045                 2050                 2055             


Thr Phe  Pro Ile Asn Ala Tyr  Thr Thr Gly Pro Cys  Thr Pro Leu 
    2060                 2065                 2070             


Pro Ala  Pro Asn Tyr Thr Phe  Ala Leu Trp Arg Val  Ser Ala Glu 
    2075                 2080                 2085             


Glu Tyr  Val Glu Ile Arg Gln  Val Gly Asp Phe His  Tyr Val Thr 
    2090                 2095                 2100             


Gly Met  Thr Thr Asp Asn Leu  Lys Cys Pro Cys Gln  Val Pro Ser 
    2105                 2110                 2115             


Pro Glu  Phe Phe Thr Glu Leu  Asp Gly Val Arg Leu  His Arg Phe 
    2120                 2125                 2130             


Ala Pro  Pro Cys Lys Pro Leu  Leu Arg Glu Glu Val  Ser Phe Arg 
    2135                 2140                 2145             


Val Gly  Leu His Glu Tyr Pro  Val Gly Ser Gln Leu  Pro Cys Glu 
    2150                 2155                 2160             


Pro Glu  Pro Asp Val Ala Val  Leu Thr Ser Met Leu  Thr Asp Pro 
    2165                 2170                 2175             


Ser His  Ile Thr Ala Glu Ala  Ala Gly Arg Arg Leu  Ala Arg Gly 
    2180                 2185                 2190             


Ser Pro  Pro Ser Met Ala Ser  Ser Ser Ala Ser Gln  Leu Ser Ala 
    2195                 2200                 2205             


Pro Ser  Leu Arg Ala Thr Cys  Thr Thr Asn His Asp  Ser Pro Asp 
    2210                 2215                 2220             


Ala Glu  Leu Ile Glu Ala Asn  Leu Leu Trp Arg Gln  Glu Met Gly 
    2225                 2230                 2235             


Gly Asn  Ile Thr Arg Val Glu  Ser Glu Asn Lys Val  Val Ile Leu 
    2240                 2245                 2250             


Asp Ser  Phe Asp Pro Leu Val  Ala Glu Glu Asp Glu  Arg Glu Val 
    2255                 2260                 2265             


Ser Val  Pro Ala Glu Ile Leu  Arg Lys Ser Arg Lys  Phe Thr Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ile Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Pro  Trp Lys Lys Pro Asp  Tyr Glu Pro Pro Val  Val His Gly 
    2300                 2305                 2310             


Cys Pro  Leu Pro Pro Pro Gln  Ser Pro Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Lys Lys  Arg Thr Val Ile Leu  Thr Glu Ser Thr Leu  Pro Thr Ala 
    2330                 2335                 2340             


Leu Ala  Glu Leu Ala Thr Lys  Ser Phe Gly Ser Ser  Ser Thr Ser 
    2345                 2350                 2355             


Gly Ile  Thr Gly Asp Asp Thr  Thr Thr Ser Pro Glu  Pro Ala Ser 
    2360                 2365                 2370             


Ser Ser  Cys Pro Pro Asp Ser  Asp Ala Glu Ser Tyr  Ser Ser Met 
    2375                 2380                 2385             


Pro Pro  Leu Glu Gly Glu Pro  Gly Asp Pro Asp Leu  Ser Asp Gly 
    2390                 2395                 2400             


Ser Trp  Ser Thr Val Ser Ser  Glu Ala Asp Lys Glu  Asp Val Val 
    2405                 2410                 2415             


Cys Cys  Ser Met Ser Tyr Ser  Trp Thr Gly Ala Leu  Ile Thr Pro 
    2420                 2425                 2430             


Cys Ser  Pro Glu Glu Glu Lys  Leu Pro Ile Asn Pro  Leu Ser Asn 
    2435                 2440                 2445             


Ser Leu  Leu Arg Tyr His Asn  Lys Val Tyr Cys Thr  Thr Ser Lys 
    2450                 2455                 2460             


Ser Ala  Ser Gln Arg Ala Lys  Lys Val Thr Phe Asp  Arg Thr Gln 
    2465                 2470                 2475             


Val Leu  Asp Ala His Tyr Asp  Ser Val Leu Lys Asp  Ile Lys Leu 
    2480                 2485                 2490             


Ala Ala  Ser Lys Val Ser Ala  Arg Leu Leu Thr Leu  Glu Glu Ala 
    2495                 2500                 2505             


Cys Gln  Leu Thr Pro Pro His  Ser Ala Arg Ser Lys  Tyr Gly Phe 
    2510                 2515                 2520             


Gly Ala  Lys Glu Val Arg Ser  Leu Ser Gly Arg Ala  Val Asn His 
    2525                 2530                 2535             


Ile Lys  Ser Val Trp Lys Asp  Leu Leu Glu Asp Pro  Gln Thr Pro 
    2540                 2545                 2550             


Ile Pro  Thr Thr Ile Met Ala  Lys Asn Glu Val Phe  Cys Val Asp 
    2555                 2560                 2565             


Pro Ala  Lys Gly Gly Lys Lys  Pro Ala Arg Leu Ile  Val Tyr Pro 
    2570                 2575                 2580             


Asp Leu  Gly Val Arg Val Cys  Glu Lys Met Ala Leu  Tyr Asp Ile 
    2585                 2590                 2595             


Thr Gln  Lys Leu Pro Gln Ala  Val Met Gly Ala Ser  Tyr Gly Phe 
    2600                 2605                 2610             


Gln Tyr  Ser Pro Ala Gln Arg  Val Glu Tyr Leu Leu  Lys Ala Trp 
    2615                 2620                 2625             


Ala Glu  Lys Lys Asp Pro Met  Gly Phe Ser Tyr Asp  Thr Arg Cys 
    2630                 2635                 2640             


Phe Asp  Ser Thr Val Thr Glu  Arg Asp Ile Arg Thr  Glu Glu Ser 
    2645                 2650                 2655             


Ile Tyr  Gln Ala Cys Ser Leu  Pro Glu Glu Ala Arg  Thr Ala Ile 
    2660                 2665                 2670             


His Ser  Leu Thr Glu Arg Leu  Tyr Val Gly Gly Pro  Met Phe Asn 
    2675                 2680                 2685             


Ser Lys  Gly Gln Thr Cys Gly  Tyr Arg Arg Cys Arg  Ala Ser Gly 
    2690                 2695                 2700             


Val Leu  Thr Thr Ser Met Gly  Asn Thr Ile Thr Cys  Tyr Val Lys 
    2705                 2710                 2715             


Ala Leu  Ala Ala Cys Lys Ala  Ala Gly Ile Val Ala  Pro Thr Met 
    2720                 2725                 2730             


Leu Val  Cys Gly Asp Asp Leu  Val Val Ile Ser Glu  Ser Gln Gly 
    2735                 2740                 2745             


Thr Glu  Glu Asp Glu Arg Asn  Leu Arg Ala Phe Thr  Glu Ala Met 
    2750                 2755                 2760             


Thr Arg  Tyr Ser Ala Pro Pro  Gly Asp Pro Pro Arg  Pro Glu Tyr 
    2765                 2770                 2775             


Asp Leu  Glu Leu Ile Thr Ser  Cys Ser Ser Asn Val  Ser Val Ala 
    2780                 2785                 2790             


Leu Gly  Pro Arg Gly Arg Arg  Arg Tyr Tyr Leu Thr  Arg Asp Pro 
    2795                 2800                 2805             


Thr Thr  Pro Leu Ala Arg Ala  Ala Trp Glu Thr Val  Arg His Ser 
    2810                 2815                 2820             


Pro Ile  Asn Ser Trp Leu Gly  Asn Ile Ile Gln Tyr  Ala Pro Thr 
    2825                 2830                 2835             


Ile Trp  Val Arg Met Val Leu  Met Thr His Phe Phe  Ser Ile Leu 
    2840                 2845                 2850             


Met Val  Gln Asp Thr Leu Asp  Gln Asn Leu Asn Phe  Glu Met Tyr 
    2855                 2860                 2865             


Gly Ser  Val Tyr Ser Val Asn  Pro Leu Asp Leu Pro  Ala Ile Ile 
    2870                 2875                 2880             


Glu Arg  Leu His Gly Leu Asp  Ala Phe Ser Met His  Thr Tyr Ser 
    2885                 2890                 2895             


His His  Glu Leu Thr Arg Val  Ala Ser Ala Leu Arg  Lys Leu Gly 
    2900                 2905                 2910             


Ala Pro  Pro Leu Arg Val Trp  Lys Ser Arg Ala Arg  Ala Val Arg 
    2915                 2920                 2925             


Ala Ser  Leu Ile Ser Arg Gly  Gly Lys Ala Ala Val  Cys Gly Arg 
    2930                 2935                 2940             


Tyr Leu  Phe Asn Trp Ala Val  Lys Thr Lys Leu Lys  Leu Thr Pro 
    2945                 2950                 2955             


Leu Pro  Glu Ala Arg Leu Leu  Asp Leu Ser Ser Trp  Phe Thr Val 
    2960                 2965                 2970             


Gly Ala  Gly Gly Gly Asp Ile  Phe His Ser Val Ser  Arg Ala Arg 
    2975                 2980                 2985             


Pro Arg  Ser Leu Leu Phe Gly  Leu Leu Leu Leu Phe  Val Gly Val 
    2990                 2995                 3000             


Gly Leu  Phe Leu Leu Pro Ala  Arg 
    3005                 3010     


<210>  147
<211>  3011
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  plasmid

<400>  147

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Gly Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Thr Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Phe Glu Ala Ala Asp Ala Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Val Thr Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Thr Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Ser Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Ala Leu Leu Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Met Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr Tyr Val Thr Gly Gly Ser Ala Ala Arg Thr Thr Ala Gly Leu Ala 
385                 390                 395                 400 


Ser Leu Phe Ser Pro Gly Ala Lys Gln Asn Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Asn Thr Gly Trp Ile Ala Gly Leu Phe Tyr His His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Ser Glu Arg Leu Ala Ser Cys Arg Pro Leu Thr Asp 
    450                 455                 460                 


Phe Ala Gln Gly Trp Gly Pro Ile Ser His Ala Asp Gly Ser Gly Pro 
465                 470                 475                 480 


Asp Gln Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Lys Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly Ala Pro Thr Tyr Ser 
        515                 520                 525             


Trp Gly Ala Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu Arg Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Ile Asn Tyr 
    610                 615                 620                 


Thr Val Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Glu Ala Ala Cys Asn Trp Thr Arg Gly Asp Arg Cys Asn Leu Asp Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Ile Ala Ser Trp Ala Ile Lys Trp Glu Tyr Val Val 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Val Glu Ala Ala Leu Glu Asn Leu Val 
            740                 745                 750         


Val Leu Asn Ala Ala Ser Leu Ala Gly Thr His Gly Leu Val Ser Phe 
        755                 760                 765             


Leu Val Phe Phe Cys Phe Ala Trp Tyr Leu Lys Gly Lys Trp Val Pro 
    770                 775                 780                 


Gly Ala Val Tyr Ala Leu Tyr Gly Met Trp Pro Leu Leu Leu Leu Leu 
785                 790                 795                 800 


Leu Ala Leu Pro Gln Arg Ala Tyr Ala Leu Asp Thr Glu Val Ala Ala 
                805                 810                 815     


Ser Cys Gly Gly Val Val Leu Val Gly Leu Met Ala Leu Thr Leu Ser 
            820                 825                 830         


Pro Tyr Tyr Lys Arg Tyr Ile Ser Trp Cys Leu Trp Trp Leu Gln Tyr 
        835                 840                 845             


Phe Leu Thr Arg Ile Glu Ala Gln Leu His Val Trp Ile Pro Pro Leu 
    850                 855                 860                 


Asn Val Arg Gly Gly Arg Asp Ala Val Ile Leu Leu Met Cys Val Val 
865                 870                 875                 880 


His Pro Ala Leu Val Phe Asp Ile Thr Lys Leu Leu Leu Ala Ala Phe 
                885                 890                 895     


Gly Pro Leu Trp Ile Leu Gln Ala Ser Leu Leu Lys Val Pro Tyr Phe 
            900                 905                 910         


Val Arg Val Gln Gly Leu Leu Arg Ile Cys Ala Leu Ala Arg Lys Met 
        915                 920                 925             


Ala Gly Gly His Tyr Val Gln Met Ala Ile Ile Lys Leu Gly Ala Leu 
    930                 935                 940                 


Thr Gly Thr Tyr Val Tyr Asn His Leu Thr Pro Leu Arg Asp Trp Ala 
945                 950                 955                 960 


His Asn Gly Leu Arg Asp Leu Ala Val Ala Val Glu Pro Val Val Phe 
                965                 970                 975     


Ser Arg Met Glu Thr Lys Leu Ile Thr Trp Gly Ala Asp Thr Ala Ala 
            980                 985                 990         


Cys Gly Asp Ile Ile Asn Gly Leu  Pro Val Ser Ala Arg  Arg Gly Arg 
        995                 1000                 1005             


Glu Ile  Leu Leu Gly Pro Ala  Asp Gly Met Val Ser  Lys Gly Trp 
    1010                 1015                 1020             


Arg Leu  Leu Ala Pro Ile Thr  Ala Tyr Ala Gln Gln  Thr Arg Gly 
    1025                 1030                 1035             


Leu Leu  Gly Cys Ile Ile Thr  Ser Leu Thr Gly Arg  Asp Lys Asn 
    1040                 1045                 1050             


Gln Val  Glu Gly Glu Ile Gln  Ile Val Ser Thr Ala  Ala Gln Thr 
    1055                 1060                 1065             


Phe Leu  Ala Thr Cys Ile Asn  Gly Val Cys Trp Thr  Val Tyr His 
    1070                 1075                 1080             


Gly Ala  Gly Thr Arg Thr Ile  Ala Ser Pro Lys Gly  Pro Val Ile 
    1085                 1090                 1095             


Gln Met  Tyr Thr Asn Val Asp  Lys Asp Leu Val Gly  Trp Pro Ala 
    1100                 1105                 1110             


Pro Gln  Gly Ala Arg Ser Leu  Thr Pro Cys Thr Cys  Gly Ser Ser 
    1115                 1120                 1125             


Asp Leu  Tyr Leu Val Thr Arg  His Ala Asp Val Ile  Pro Val Arg 
    1130                 1135                 1140             


Arg Arg  Gly Asp Ser Arg Gly  Ser Leu Leu Ser Pro  Arg Pro Ile 
    1145                 1150                 1155             


Ser Tyr  Leu Lys Gly Ser Ser  Gly Gly Pro Leu Leu  Cys Pro Ala 
    1160                 1165                 1170             


Gly His  Ala Val Gly Leu Phe  Arg Ala Ala Val Cys  Thr Arg Gly 
    1175                 1180                 1185             


Val Ala  Lys Ala Val Asp Phe  Ile Pro Val Glu Asn  Leu Glu Thr 
    1190                 1195                 1200             


Thr Met  Arg Ser Pro Val Phe  Thr Asp Asn Ser Ser  Pro Pro Ala 
    1205                 1210                 1215             


Val Pro  Gln Ser Phe Gln Val  Ala His Leu His Ala  Pro Thr Gly 
    1220                 1225                 1230             


Ser Gly  Lys Ser Thr Lys Val  Pro Ala Ala Tyr Ala  Ala Gln Gly 
    1235                 1240                 1245             


Tyr Lys  Val Leu Val Leu Asn  Pro Ser Val Ala Ala  Thr Leu Gly 
    1250                 1255                 1260             


Phe Gly  Ala Tyr Met Ser Lys  Ala His Gly Val Asp  Pro Asn Ile 
    1265                 1270                 1275             


Arg Thr  Gly Val Arg Thr Ile  Thr Thr Gly Ser Pro  Ile Thr Tyr 
    1280                 1285                 1290             


Ser Thr  Tyr Gly Lys Phe Leu  Ala Asp Gly Gly Cys  Ser Gly Gly 
    1295                 1300                 1305             


Ala Tyr  Asp Ile Ile Ile Cys  Asp Glu Cys His Ser  Thr Asp Ala 
    1310                 1315                 1320             


Thr Ser  Ile Leu Gly Ile Gly  Thr Val Leu Asp Gln  Ala Glu Thr 
    1325                 1330                 1335             


Ala Gly  Ala Arg Leu Val Val  Leu Ala Thr Ala Thr  Pro Pro Gly 
    1340                 1345                 1350             


Ser Ile  Thr Val Pro His Pro  Asn Ile Glu Glu Val  Ala Leu Ser 
    1355                 1360                 1365             


Thr Thr  Gly Glu Ile Pro Phe  Tyr Gly Lys Ala Ile  Pro Leu Glu 
    1370                 1375                 1380             


Ala Ile  Lys Gly Gly Arg His  Leu Ile Phe Cys His  Ser Lys Lys 
    1385                 1390                 1395             


Lys Cys  Asp Glu Leu Ala Ala  Lys Leu Val Ala Leu  Gly Ile Asn 
    1400                 1405                 1410             


Ala Val  Ala Tyr Tyr Arg Gly  Leu Asp Val Ser Val  Ile Pro Thr 
    1415                 1420                 1425             


Ser Gly  Asp Val Val Val Val  Ala Thr Asp Ala Leu  Met Thr Gly 
    1430                 1435                 1440             


Tyr Thr  Gly Asp Phe Asp Ser  Val Ile Asp Cys Asn  Thr Cys Val 
    1445                 1450                 1455             


Thr Gln  Thr Val Asp Leu Ser  Leu Asp Pro Thr Phe  Thr Ile Glu 
    1460                 1465                 1470             


Thr Thr  Thr Leu Pro Gln Asp  Ala Val Ser Arg Thr  Gln Arg Arg 
    1475                 1480                 1485             


Gly Arg  Thr Gly Arg Gly Lys  Pro Gly Ile Tyr Arg  Phe Val Ala 
    1490                 1495                 1500             


Leu Gly  Glu Arg Pro Ser Gly  Met Phe Asp Ser Ser  Val Leu Cys 
    1505                 1510                 1515             


Glu Cys  Tyr Asp Ala Gly Cys  Ala Trp Tyr Glu Leu  Thr Pro Ala 
    1520                 1525                 1530             


Glu Thr  Thr Val Arg Leu Arg  Ala Tyr Met Asn Thr  Pro Gly Leu 
    1535                 1540                 1545             


Pro Val  Cys Gln Asp His Leu  Glu Phe Trp Glu Gly  Val Phe Thr 
    1550                 1555                 1560             


Gly Leu  Thr His Ile Asp Ala  His Phe Leu Ser Gln  Thr Lys Gln 
    1565                 1570                 1575             


Ser Gly  Glu Asn Phe Pro Tyr  Leu Val Ala Tyr Gln  Ala Thr Val 
    1580                 1585                 1590             


Cys Ala  Arg Ala Gln Ala Pro  Pro Pro Ser Trp Asp  Gln Met Trp 
    1595                 1600                 1605             


Lys Cys  Leu Thr Arg Leu Lys  Pro Thr Leu His Gly  Pro Thr Pro 
    1610                 1615                 1620             


Leu Leu  Tyr Arg Leu Gly Ala  Val Gln Asn Glu Val  Thr Leu Thr 
    1625                 1630                 1635             


His Pro  Ile Thr Lys Tyr Ile  Met Thr Cys Met Ser  Ala Asp Leu 
    1640                 1645                 1650             


Glu Val  Val Thr Ser Thr Trp  Val Leu Val Gly Gly  Val Leu Ala 
    1655                 1660                 1665             


Ala Leu  Ala Ser Tyr Cys Leu  Ser Thr Gly Cys Val  Val Ile Val 
    1670                 1675                 1680             


Gly Arg  Ile Val Leu Ser Gly  Lys Pro Ala Ile Ile  Pro Asp Arg 
    1685                 1690                 1695             


Glu Val  Leu Tyr Arg Glu Phe  Asp Glu Met Glu Glu  Cys Ser Gln 
    1700                 1705                 1710             


His Leu  Pro Tyr Ile Glu Gln  Gly Met Met Leu Ala  Glu Gln Phe 
    1715                 1720                 1725             


Lys Gln  Lys Ala Leu Gly Leu  Leu Gln Thr Ala Ser  Arg Gln Ala 
    1730                 1735                 1740             


Glu Val  Val Ala Pro Ala Val  Gln Thr Asn Trp Gln  Lys Leu Glu 
    1745                 1750                 1755             


Ala Phe  Trp Ala Lys His Met  Trp Asn Phe Ile Ser  Gly Ile Gln 
    1760                 1765                 1770             


Tyr Leu  Ala Gly Leu Ser Thr  Leu Pro Gly Asn Pro  Ala Ile Ala 
    1775                 1780                 1785             


Ser Leu  Met Ala Phe Thr Ala  Ala Val Thr Ser Pro  Leu Thr Thr 
    1790                 1795                 1800             


Ser Gln  Thr Leu Leu Phe Asn  Ile Leu Gly Gly Trp  Val Ala Ala 
    1805                 1810                 1815             


Gln Leu  Ala Ala Pro Gly Ala  Ala Thr Ala Phe Val  Gly Ala Gly 
    1820                 1825                 1830             


Leu Ala  Gly Ala Ala Ile Gly  Ser Val Gly Leu Gly  Lys Val Leu 
    1835                 1840                 1845             


Val Asp  Ile Leu Ala Gly Tyr  Gly Ala Gly Val Ala  Gly Ala Leu 
    1850                 1855                 1860             


Val Ala  Phe Lys Ile Met Ser  Gly Glu Val Pro Ser  Thr Glu Asp 
    1865                 1870                 1875             


Leu Val  Asn Leu Leu Pro Ala  Ile Leu Ser Pro Gly  Ala Leu Val 
    1880                 1885                 1890             


Val Gly  Val Val Cys Ala Ala  Ile Leu Arg Arg His  Val Gly Pro 
    1895                 1900                 1905             


Gly Glu  Gly Ala Val Gln Trp  Met Asn Arg Leu Ile  Ala Phe Ala 
    1910                 1915                 1920             


Ser Arg  Gly Asn His Val Ser  Pro Thr His Tyr Val  Pro Glu Ser 
    1925                 1930                 1935             


Asp Ala  Ala Ala Arg Val Thr  Thr Ile Leu Ser Ser  Leu Thr Val 
    1940                 1945                 1950             


Thr Gln  Leu Leu Arg Arg Leu  His Gln Trp Ile Ser  Ser Glu Cys 
    1955                 1960                 1965             


Thr Thr  Pro Cys Ser Gly Ser  Trp Leu Arg Asp Ile  Trp Asp Trp 
    1970                 1975                 1980             


Ile Cys  Glu Val Leu Ser Asp  Phe Lys Thr Trp Leu  Lys Ala Lys 
    1985                 1990                 1995             


Leu Met  Pro Gln Leu Pro Gly  Ile Pro Phe Val Ser  Cys Gln Arg 
    2000                 2005                 2010             


Gly Tyr  Lys Gly Val Trp Arg  Gly Asp Gly Ile Met  His Thr Arg 
    2015                 2020                 2025             


Cys His  Cys Gly Ala Glu Ile  Thr Gly His Val Lys  Asn Gly Thr 
    2030                 2035                 2040             


Met Arg  Ile Val Gly Pro Lys  Thr Cys Arg Asn Met  Trp Ser Gly 
    2045                 2050                 2055             


Thr Phe  Pro Ile Asn Ala Tyr  Thr Thr Gly Pro Cys  Thr Pro Leu 
    2060                 2065                 2070             


Pro Ala  Pro Asn Tyr Thr Phe  Ala Leu Trp Arg Val  Ser Ala Glu 
    2075                 2080                 2085             


Glu Tyr  Val Glu Ile Arg Gln  Val Gly Asp Phe His  Tyr Val Thr 
    2090                 2095                 2100             


Gly Met  Thr Thr Asp Asn Leu  Lys Cys Pro Cys Gln  Val Pro Ser 
    2105                 2110                 2115             


Pro Glu  Phe Phe Thr Glu Leu  Asp Gly Val Arg Leu  His Arg Phe 
    2120                 2125                 2130             


Ala Pro  Pro Cys Lys Pro Leu  Leu Arg Glu Glu Val  Ser Phe Arg 
    2135                 2140                 2145             


Val Gly  Leu His Glu Tyr Pro  Val Gly Ser Gln Leu  Pro Cys Glu 
    2150                 2155                 2160             


Pro Glu  Pro Asp Val Ala Val  Leu Thr Ser Met Leu  Thr Asp Pro 
    2165                 2170                 2175             


Ser His  Ile Thr Ala Glu Ala  Ala Gly Arg Arg Leu  Ala Arg Gly 
    2180                 2185                 2190             


Ser Pro  Pro Ser Met Ala Ser  Ser Ser Ala Ser Gln  Leu Ser Ala 
    2195                 2200                 2205             


Pro Ser  Leu Arg Ala Thr Cys  Thr Thr Asn His Asp  Ser Pro Asp 
    2210                 2215                 2220             


Ala Glu  Leu Ile Glu Ala Asn  Leu Leu Trp Arg Gln  Glu Met Gly 
    2225                 2230                 2235             


Gly Asn  Ile Thr Arg Val Glu  Ser Glu Asn Lys Val  Val Ile Leu 
    2240                 2245                 2250             


Asp Ser  Phe Asp Pro Leu Val  Ala Glu Glu Asp Glu  Arg Glu Val 
    2255                 2260                 2265             


Ser Val  Pro Ala Glu Ile Leu  Arg Lys Ser Arg Lys  Phe Thr Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ile Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Pro  Trp Lys Lys Pro Asp  Tyr Glu Pro Pro Val  Val His Gly 
    2300                 2305                 2310             


Cys Pro  Leu Pro Pro Pro Gln  Ser Pro Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Lys Lys  Arg Thr Val Ile Leu  Thr Glu Ser Thr Leu  Pro Thr Ala 
    2330                 2335                 2340             


Leu Ala  Glu Leu Ala Thr Lys  Ser Phe Gly Ser Ser  Ser Thr Ser 
    2345                 2350                 2355             


Gly Ile  Thr Gly Asp Asp Thr  Thr Thr Ser Pro Glu  Pro Ala Ser 
    2360                 2365                 2370             


Ser Ser  Cys Pro Pro Asp Ser  Asp Ala Glu Ser Tyr  Ser Ser Met 
    2375                 2380                 2385             


Pro Pro  Leu Glu Gly Glu Pro  Gly Asp Pro Asp Leu  Ser Asp Gly 
    2390                 2395                 2400             


Ser Trp  Ser Thr Val Ser Ser  Glu Ala Asp Lys Glu  Asp Val Val 
    2405                 2410                 2415             


Cys Cys  Ser Met Ser Tyr Ser  Trp Thr Gly Ala Leu  Ile Thr Pro 
    2420                 2425                 2430             


Cys Ser  Pro Glu Glu Glu Lys  Leu Pro Ile Asn Pro  Leu Ser Asn 
    2435                 2440                 2445             


Ser Leu  Leu Arg Tyr His Asn  Lys Val Tyr Cys Thr  Thr Ser Lys 
    2450                 2455                 2460             


Ser Ala  Ser Gln Arg Ala Lys  Lys Val Thr Phe Asp  Arg Thr Gln 
    2465                 2470                 2475             


Val Leu  Asp Ala His Tyr Asp  Ser Val Leu Lys Asp  Ile Lys Leu 
    2480                 2485                 2490             


Ala Ala  Ser Lys Val Ser Ala  Arg Leu Leu Thr Leu  Glu Glu Ala 
    2495                 2500                 2505             


Cys Gln  Leu Thr Pro Pro His  Ser Ala Arg Ser Lys  Tyr Gly Phe 
    2510                 2515                 2520             


Gly Ala  Lys Glu Val Arg Ser  Leu Ser Gly Arg Ala  Val Asn His 
    2525                 2530                 2535             


Ile Lys  Ser Val Trp Lys Asp  Leu Leu Glu Asp Pro  Gln Thr Pro 
    2540                 2545                 2550             


Ile Pro  Thr Thr Ile Met Ala  Lys Asn Glu Val Phe  Cys Val Asp 
    2555                 2560                 2565             


Pro Ala  Lys Gly Gly Lys Lys  Pro Ala Arg Leu Ile  Val Tyr Pro 
    2570                 2575                 2580             


Asp Leu  Gly Val Arg Val Cys  Glu Lys Met Ala Leu  Tyr Asp Ile 
    2585                 2590                 2595             


Thr Gln  Lys Leu Pro Gln Ala  Val Met Gly Ala Ser  Tyr Gly Phe 
    2600                 2605                 2610             


Gln Tyr  Ser Pro Ala Gln Arg  Val Glu Tyr Leu Leu  Lys Ala Trp 
    2615                 2620                 2625             


Ala Glu  Lys Lys Asp Pro Met  Gly Phe Ser Tyr Asp  Thr Arg Cys 
    2630                 2635                 2640             


Phe Asp  Ser Thr Val Thr Glu  Arg Asp Ile Arg Thr  Glu Glu Ser 
    2645                 2650                 2655             


Ile Tyr  Gln Ala Cys Ser Leu  Pro Glu Glu Ala Arg  Thr Ala Ile 
    2660                 2665                 2670             


His Ser  Leu Thr Glu Arg Leu  Tyr Val Gly Gly Pro  Met Phe Asn 
    2675                 2680                 2685             


Ser Lys  Gly Gln Thr Cys Gly  Tyr Arg Arg Cys Arg  Ala Ser Gly 
    2690                 2695                 2700             


Val Leu  Thr Thr Ser Met Gly  Asn Thr Ile Thr Cys  Tyr Val Lys 
    2705                 2710                 2715             


Ala Leu  Ala Ala Cys Lys Ala  Ala Gly Ile Val Ala  Pro Thr Met 
    2720                 2725                 2730             


Leu Val  Cys Gly Asp Asp Leu  Val Val Ile Ser Glu  Ser Gln Gly 
    2735                 2740                 2745             


Thr Glu  Glu Asp Glu Arg Asn  Leu Arg Ala Phe Thr  Glu Ala Met 
    2750                 2755                 2760             


Thr Arg  Tyr Ser Ala Pro Pro  Gly Asp Pro Pro Arg  Pro Glu Tyr 
    2765                 2770                 2775             


Asp Leu  Glu Leu Ile Thr Ser  Cys Ser Ser Asn Val  Ser Val Ala 
    2780                 2785                 2790             


Leu Gly  Pro Arg Gly Arg Arg  Arg Tyr Tyr Leu Thr  Arg Asp Pro 
    2795                 2800                 2805             


Thr Thr  Pro Leu Ala Arg Ala  Ala Trp Glu Thr Val  Arg His Ser 
    2810                 2815                 2820             


Pro Ile  Asn Ser Trp Leu Gly  Asn Ile Ile Gln Tyr  Ala Pro Thr 
    2825                 2830                 2835             


Ile Trp  Val Arg Met Val Leu  Met Thr His Phe Phe  Ser Ile Leu 
    2840                 2845                 2850             


Met Val  Gln Asp Thr Leu Asp  Gln Asn Leu Asn Phe  Glu Met Tyr 
    2855                 2860                 2865             


Gly Ser  Val Tyr Ser Val Asn  Pro Leu Asp Leu Pro  Ala Ile Ile 
    2870                 2875                 2880             


Glu Arg  Leu His Gly Leu Asp  Ala Phe Ser Met His  Thr Tyr Ser 
    2885                 2890                 2895             


His His  Glu Leu Thr Arg Val  Ala Ser Ala Leu Arg  Lys Leu Gly 
    2900                 2905                 2910             


Ala Pro  Pro Leu Arg Val Trp  Lys Ser Arg Ala Arg  Ala Val Arg 
    2915                 2920                 2925             


Ala Ser  Leu Ile Ser Arg Gly  Gly Lys Ala Ala Val  Cys Gly Arg 
    2930                 2935                 2940             


Tyr Leu  Phe Asn Trp Ala Val  Lys Thr Lys Leu Lys  Leu Thr Pro 
    2945                 2950                 2955             


Leu Pro  Glu Ala Arg Leu Leu  Asp Leu Ser Ser Trp  Phe Thr Val 
    2960                 2965                 2970             


Gly Ala  Gly Gly Gly Gly Ile  Phe His Ser Val Ser  Arg Ala Arg 
    2975                 2980                 2985             


Pro Arg  Ser Leu Leu Phe Gly  Leu Leu Leu Leu Phe  Val Gly Val 
    2990                 2995                 3000             


Gly Leu  Phe Leu Leu Pro Ala  Arg 
    3005                 3010     


<210>  148
<211>  3011
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  plasmid

<400>  148

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Gly Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Thr Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Phe Glu Ala Ala Asp Ala Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Val Thr Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Thr Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Ser Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Ala Leu Leu Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Met Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr Tyr Val Thr Gly Gly Ser Ala Ala Arg Thr Thr Ala Gly Leu Ala 
385                 390                 395                 400 


Ser Leu Phe Ser Pro Gly Ala Lys Gln Asn Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Asn Thr Gly Trp Ile Ala Gly Leu Phe Tyr His His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Ser Glu Arg Leu Ala Ser Cys Arg Pro Leu Thr Asp 
    450                 455                 460                 


Phe Ala Gln Gly Trp Gly Pro Ile Ser His Ala Asp Gly Ser Gly Pro 
465                 470                 475                 480 


Asp Gln Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Lys Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly Ala Pro Thr Tyr Ser 
        515                 520                 525             


Trp Gly Ala Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu Arg Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Ile Asn Tyr 
    610                 615                 620                 


Thr Val Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Glu Ala Ala Cys Asn Trp Thr Arg Gly Asp Arg Cys Asn Leu Asp Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Ile Ala Ser Trp Ala Ile Lys Trp Glu Tyr Val Val 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Val Glu Ala Ala Leu Glu Asn Leu Val 
            740                 745                 750         


Val Leu Asn Ala Ala Ser Leu Ala Gly Thr His Gly Leu Val Ser Phe 
        755                 760                 765             


Leu Val Phe Phe Cys Phe Ala Trp Tyr Leu Lys Gly Lys Trp Val Pro 
    770                 775                 780                 


Gly Ala Val Tyr Ala Leu Tyr Gly Met Trp Pro Leu Leu Leu Leu Leu 
785                 790                 795                 800 


Leu Ala Leu Pro Gln Arg Ala Tyr Ala Leu Asp Thr Glu Val Ala Ala 
                805                 810                 815     


Ser Cys Gly Gly Val Val Leu Val Gly Leu Met Ala Leu Thr Leu Ser 
            820                 825                 830         


Pro Tyr Tyr Lys Arg Tyr Ile Ser Trp Cys Leu Trp Trp Leu Gln Tyr 
        835                 840                 845             


Phe Leu Thr Arg Ile Glu Ala Gln Leu His Val Trp Ile Pro Pro Leu 
    850                 855                 860                 


Asn Val Arg Gly Gly Arg Asp Ala Val Ile Leu Leu Met Cys Val Val 
865                 870                 875                 880 


His Pro Ala Leu Val Phe Asp Ile Thr Lys Leu Leu Leu Ala Ala Phe 
                885                 890                 895     


Gly Pro Leu Trp Ile Leu Gln Ala Ser Leu Leu Lys Val Pro Tyr Phe 
            900                 905                 910         


Val Arg Val Gln Gly Leu Leu Arg Ile Cys Ala Leu Ala Arg Lys Met 
        915                 920                 925             


Ala Gly Gly His Tyr Val Gln Met Ala Ile Ile Lys Leu Gly Ala Leu 
    930                 935                 940                 


Thr Gly Thr Tyr Val Tyr Asn His Leu Thr Pro Leu Arg Asp Trp Ala 
945                 950                 955                 960 


His Asn Gly Leu Arg Asp Leu Ala Val Ala Val Glu Pro Val Val Phe 
                965                 970                 975     


Ser Arg Met Glu Thr Lys Leu Ile Thr Trp Gly Ala Asp Thr Ala Ala 
            980                 985                 990         


Cys Gly Asp Ile Ile Asn Gly Leu  Pro Val Ser Ala Arg  Arg Gly Arg 
        995                 1000                 1005             


Glu Ile  Leu Leu Gly Pro Ala  Asp Gly Met Val Ser  Lys Gly Trp 
    1010                 1015                 1020             


Arg Leu  Leu Ala Pro Ile Thr  Ala Tyr Ala Gln Gln  Thr Arg Gly 
    1025                 1030                 1035             


Leu Leu  Gly Cys Ile Ile Thr  Ser Leu Thr Gly Arg  Asp Lys Asn 
    1040                 1045                 1050             


Gln Val  Glu Gly Glu Ile Gln  Ile Val Ser Thr Ala  Ala Gln Thr 
    1055                 1060                 1065             


Phe Leu  Ala Thr Cys Ile Asn  Gly Val Cys Trp Thr  Val Tyr His 
    1070                 1075                 1080             


Gly Ala  Gly Thr Arg Thr Ile  Ala Ser Pro Lys Gly  Pro Val Ile 
    1085                 1090                 1095             


Gln Met  Tyr Thr Asn Val Asp  Lys Asp Leu Val Gly  Trp Pro Ala 
    1100                 1105                 1110             


Pro Gln  Gly Ala Arg Ser Leu  Thr Pro Cys Thr Cys  Gly Ser Ser 
    1115                 1120                 1125             


Asp Leu  Tyr Leu Val Thr Arg  His Ala Asp Val Ile  Pro Val Arg 
    1130                 1135                 1140             


Arg Arg  Gly Asp Ser Arg Gly  Ser Leu Leu Ser Pro  Arg Pro Ile 
    1145                 1150                 1155             


Ser Tyr  Leu Lys Gly Ser Ser  Gly Gly Pro Leu Leu  Cys Pro Ala 
    1160                 1165                 1170             


Gly His  Ala Val Gly Leu Phe  Arg Ala Ala Val Cys  Thr Arg Gly 
    1175                 1180                 1185             


Val Ala  Lys Ala Val Asp Phe  Ile Pro Val Glu Asn  Leu Glu Thr 
    1190                 1195                 1200             


Thr Met  Arg Ser Pro Val Phe  Thr Asp Asn Ser Ser  Pro Pro Ala 
    1205                 1210                 1215             


Val Pro  Gln Ser Phe Gln Val  Gly His Leu His Ala  Pro Thr Gly 
    1220                 1225                 1230             


Ser Gly  Lys Ser Thr Lys Val  Pro Ala Ala Tyr Ala  Ala Gln Gly 
    1235                 1240                 1245             


Tyr Lys  Val Leu Val Leu Asn  Pro Ser Val Ala Ala  Thr Leu Gly 
    1250                 1255                 1260             


Phe Gly  Ala Tyr Met Ser Lys  Ala His Gly Val Asp  Pro Asn Ile 
    1265                 1270                 1275             


Arg Thr  Gly Val Arg Thr Ile  Thr Thr Gly Ser Pro  Ile Thr Tyr 
    1280                 1285                 1290             


Ser Thr  Tyr Gly Lys Phe Leu  Ala Asp Gly Gly Cys  Ser Gly Gly 
    1295                 1300                 1305             


Ala Tyr  Asp Ile Ile Ile Cys  Asp Glu Cys His Ser  Thr Asp Ala 
    1310                 1315                 1320             


Thr Ser  Ile Leu Gly Ile Gly  Thr Val Leu Asp Gln  Ala Glu Thr 
    1325                 1330                 1335             


Ala Gly  Ala Arg Leu Val Val  Leu Ala Thr Ala Thr  Pro Pro Gly 
    1340                 1345                 1350             


Ser Ile  Thr Val Pro His Pro  Asn Ile Glu Glu Val  Ala Leu Ser 
    1355                 1360                 1365             


Thr Thr  Gly Glu Ile Pro Phe  Tyr Gly Lys Ala Ile  Pro Leu Glu 
    1370                 1375                 1380             


Ala Ile  Lys Gly Gly Arg His  Leu Ile Phe Cys His  Ser Lys Lys 
    1385                 1390                 1395             


Lys Cys  Asp Glu Leu Ala Ala  Lys Leu Val Ala Leu  Gly Ile Asn 
    1400                 1405                 1410             


Ala Val  Ala Tyr Tyr Arg Gly  Leu Asp Val Ser Val  Ile Pro Thr 
    1415                 1420                 1425             


Ser Gly  Asp Val Val Val Val  Ala Thr Asp Ala Leu  Met Thr Gly 
    1430                 1435                 1440             


Tyr Thr  Gly Asp Phe Asp Ser  Val Ile Asp Cys Asn  Thr Cys Val 
    1445                 1450                 1455             


Thr Gln  Thr Val Asp Leu Ser  Leu Asp Pro Thr Phe  Thr Ile Glu 
    1460                 1465                 1470             


Thr Thr  Thr Leu Pro Gln Asp  Ala Val Ser Arg Thr  Gln Arg Arg 
    1475                 1480                 1485             


Gly Arg  Thr Gly Arg Gly Lys  Pro Gly Ile Tyr Arg  Phe Val Ala 
    1490                 1495                 1500             


Leu Gly  Glu Arg Pro Ser Gly  Met Phe Asp Ser Ser  Val Leu Cys 
    1505                 1510                 1515             


Glu Cys  Tyr Asp Ala Gly Cys  Ala Trp Tyr Glu Leu  Thr Pro Ala 
    1520                 1525                 1530             


Glu Thr  Thr Val Arg Leu Arg  Ala Tyr Met Asn Thr  Pro Gly Leu 
    1535                 1540                 1545             


Pro Val  Cys Gln Asp His Leu  Glu Phe Trp Glu Gly  Val Phe Thr 
    1550                 1555                 1560             


Gly Leu  Thr His Ile Asp Ala  His Phe Leu Ser Gln  Thr Lys Gln 
    1565                 1570                 1575             


Ser Gly  Glu Asn Phe Pro Tyr  Leu Val Ala Tyr Gln  Ala Thr Val 
    1580                 1585                 1590             


Cys Ala  Arg Ala Gln Ala Pro  Pro Pro Ser Trp Asp  Gln Met Trp 
    1595                 1600                 1605             


Lys Cys  Leu Thr Arg Leu Lys  Pro Thr Leu His Gly  Pro Thr Pro 
    1610                 1615                 1620             


Leu Leu  Tyr Arg Leu Gly Ala  Val Gln Asn Glu Val  Thr Leu Thr 
    1625                 1630                 1635             


His Pro  Ile Thr Lys Tyr Ile  Met Thr Cys Met Ser  Ala Asp Leu 
    1640                 1645                 1650             


Glu Val  Val Thr Ser Thr Trp  Val Leu Val Gly Gly  Val Leu Ala 
    1655                 1660                 1665             


Ala Leu  Ala Ser Tyr Cys Leu  Ser Thr Gly Cys Val  Val Ile Val 
    1670                 1675                 1680             


Gly Arg  Ile Val Leu Ser Gly  Lys Pro Ala Ile Ile  Pro Asp Arg 
    1685                 1690                 1695             


Glu Val  Leu Tyr Arg Glu Phe  Asp Glu Met Glu Glu  Cys Ser Gln 
    1700                 1705                 1710             


His Leu  Pro Tyr Ile Glu Gln  Gly Met Met Leu Ala  Glu Gln Phe 
    1715                 1720                 1725             


Lys Gln  Lys Ala Leu Gly Leu  Leu Gln Thr Ala Ser  Arg Gln Ala 
    1730                 1735                 1740             


Glu Val  Val Ala Pro Ala Val  Gln Thr Asn Trp Gln  Lys Leu Glu 
    1745                 1750                 1755             


Ala Phe  Trp Ala Lys His Met  Trp Asn Phe Ile Ser  Gly Ile His 
    1760                 1765                 1770             


Tyr Leu  Ala Gly Leu Ser Thr  Leu Pro Gly Asn Pro  Ala Ile Ala 
    1775                 1780                 1785             


Ser Leu  Met Ala Phe Thr Ala  Ala Val Thr Ser Pro  Leu Thr Thr 
    1790                 1795                 1800             


Ser Gln  Thr Leu Leu Phe Asn  Ile Leu Gly Gly Trp  Val Ala Ala 
    1805                 1810                 1815             


Gln Leu  Ala Ala Pro Gly Ala  Ala Thr Ala Phe Val  Gly Ala Gly 
    1820                 1825                 1830             


Leu Ala  Gly Ala Ala Ile Gly  Ser Val Gly Leu Gly  Lys Val Leu 
    1835                 1840                 1845             


Val Asp  Ile Leu Ala Gly Tyr  Gly Ala Gly Val Ala  Gly Ala Leu 
    1850                 1855                 1860             


Val Ala  Phe Lys Ile Met Ser  Gly Glu Val Pro Ser  Thr Glu Asp 
    1865                 1870                 1875             


Leu Val  Asn Leu Leu Pro Ala  Ile Leu Ser Pro Gly  Ala Leu Val 
    1880                 1885                 1890             


Val Gly  Val Val Cys Ala Ala  Ile Leu Arg Arg His  Val Gly Pro 
    1895                 1900                 1905             


Gly Glu  Gly Ala Val Gln Trp  Met Asn Arg Leu Ile  Ala Phe Ala 
    1910                 1915                 1920             


Ser Arg  Gly Asn His Val Ser  Pro Thr His Tyr Val  Pro Glu Ser 
    1925                 1930                 1935             


Asp Ala  Ala Ala Arg Val Thr  Thr Ile Leu Ser Ser  Leu Thr Val 
    1940                 1945                 1950             


Thr Gln  Leu Leu Arg Arg Leu  His Gln Trp Ile Ser  Ser Glu Cys 
    1955                 1960                 1965             


Thr Thr  Pro Cys Ser Gly Ser  Trp Leu Arg Asp Ile  Trp Asp Trp 
    1970                 1975                 1980             


Ile Cys  Glu Val Leu Ser Asp  Phe Lys Thr Trp Leu  Lys Ala Lys 
    1985                 1990                 1995             


Leu Met  Pro Gln Leu Pro Gly  Ile Pro Phe Val Ser  Cys Gln Arg 
    2000                 2005                 2010             


Gly Tyr  Lys Gly Val Trp Arg  Gly Asp Gly Ile Met  His Thr Arg 
    2015                 2020                 2025             


Cys His  Cys Gly Ala Glu Ile  Thr Gly His Val Lys  Asn Gly Thr 
    2030                 2035                 2040             


Met Arg  Ile Val Gly Pro Lys  Thr Cys Arg Asn Met  Trp Ser Gly 
    2045                 2050                 2055             


Thr Phe  Pro Ile Asn Ala Tyr  Thr Thr Gly Pro Cys  Thr Pro Leu 
    2060                 2065                 2070             


Pro Ala  Pro Asn Tyr Thr Phe  Ala Leu Trp Arg Val  Ser Ala Glu 
    2075                 2080                 2085             


Glu Tyr  Val Glu Ile Arg Gln  Val Gly Asp Phe His  Tyr Val Thr 
    2090                 2095                 2100             


Gly Met  Thr Thr Asp Asn Leu  Lys Cys Pro Cys Gln  Val Pro Ser 
    2105                 2110                 2115             


Pro Glu  Phe Phe Thr Glu Leu  Asp Gly Val Arg Leu  His Arg Phe 
    2120                 2125                 2130             


Ala Pro  Pro Cys Lys Pro Leu  Leu Arg Glu Glu Val  Ser Phe Arg 
    2135                 2140                 2145             


Val Gly  Leu His Glu Tyr Pro  Val Gly Ser Gln Leu  Pro Cys Glu 
    2150                 2155                 2160             


Pro Glu  Pro Asp Val Ala Val  Leu Thr Ser Met Leu  Thr Asp Pro 
    2165                 2170                 2175             


Ser His  Ile Thr Ala Glu Ala  Ala Gly Arg Arg Leu  Ala Arg Gly 
    2180                 2185                 2190             


Ser Pro  Pro Ser Met Ala Ser  Ser Ser Ala Ser Gln  Leu Ser Ala 
    2195                 2200                 2205             


Pro Ser  Leu Arg Ala Thr Cys  Thr Thr Asn His Asp  Ser Pro Asp 
    2210                 2215                 2220             


Ala Glu  Leu Ile Glu Ala Asn  Leu Leu Trp Arg Gln  Glu Met Gly 
    2225                 2230                 2235             


Gly Asn  Ile Thr Arg Val Glu  Ser Glu Asn Lys Val  Val Ile Leu 
    2240                 2245                 2250             


Asp Ser  Phe Asp Pro Leu Val  Ala Glu Glu Asp Glu  Arg Glu Val 
    2255                 2260                 2265             


Ser Val  Pro Ala Glu Ile Leu  Arg Lys Ser Arg Lys  Phe Thr Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ile Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Pro  Trp Lys Lys Pro Asp  Tyr Glu Pro Pro Val  Val His Gly 
    2300                 2305                 2310             


Cys Pro  Leu Pro Pro Pro Gln  Ser Pro Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Lys Lys  Arg Thr Val Ile Leu  Thr Glu Ser Thr Leu  Pro Thr Ala 
    2330                 2335                 2340             


Leu Ala  Glu Leu Ala Thr Lys  Ser Phe Gly Ser Ser  Ser Thr Ser 
    2345                 2350                 2355             


Gly Ile  Thr Gly Asp Asp Thr  Thr Thr Ser Pro Glu  Pro Ala Ser 
    2360                 2365                 2370             


Ser Ser  Cys Pro Pro Asp Ser  Asp Ala Glu Ser Tyr  Ser Ser Met 
    2375                 2380                 2385             


Pro Pro  Leu Glu Gly Glu Pro  Gly Asp Pro Asp Leu  Ser Asp Gly 
    2390                 2395                 2400             


Ser Trp  Ser Thr Val Ser Ser  Glu Ala Asp Lys Glu  Asp Val Val 
    2405                 2410                 2415             


Cys Cys  Ser Met Ser Tyr Ser  Trp Thr Gly Ala Leu  Ile Thr Pro 
    2420                 2425                 2430             


Cys Ser  Pro Glu Glu Glu Lys  Leu Pro Ile Asn Pro  Leu Ser Asn 
    2435                 2440                 2445             


Ser Leu  Leu Arg Tyr His Asn  Lys Val Tyr Cys Thr  Thr Ser Lys 
    2450                 2455                 2460             


Ser Ala  Ser Gln Arg Ala Lys  Lys Val Thr Phe Asp  Arg Thr Gln 
    2465                 2470                 2475             


Val Leu  Asp Ala His Tyr Asp  Ser Val Leu Lys Asp  Ile Lys Leu 
    2480                 2485                 2490             


Ala Ala  Ser Lys Val Ser Ala  Arg Leu Leu Thr Leu  Glu Glu Ala 
    2495                 2500                 2505             


Cys Gln  Leu Thr Pro Pro His  Ser Ala Arg Ser Lys  Tyr Gly Phe 
    2510                 2515                 2520             


Gly Ala  Lys Glu Val Arg Ser  Leu Ser Gly Arg Ala  Val Asn His 
    2525                 2530                 2535             


Ile Lys  Ser Val Trp Lys Asp  Leu Leu Glu Asp Pro  Gln Thr Pro 
    2540                 2545                 2550             


Ile Pro  Thr Thr Ile Met Ala  Lys Asn Glu Val Phe  Cys Val Asp 
    2555                 2560                 2565             


Pro Ala  Lys Gly Gly Lys Lys  Pro Ala Arg Leu Ile  Val Tyr Pro 
    2570                 2575                 2580             


Asp Leu  Gly Val Arg Val Cys  Glu Lys Met Ala Leu  Tyr Asp Ile 
    2585                 2590                 2595             


Thr Gln  Lys Leu Pro Gln Ala  Val Met Gly Ala Ser  Tyr Gly Phe 
    2600                 2605                 2610             


Gln Tyr  Ser Pro Ala Gln Arg  Val Glu Tyr Leu Leu  Lys Ala Trp 
    2615                 2620                 2625             


Ala Glu  Lys Lys Asp Pro Met  Gly Phe Ser Tyr Asp  Thr Arg Cys 
    2630                 2635                 2640             


Phe Asp  Ser Thr Val Thr Glu  Arg Asp Ile Arg Thr  Glu Glu Ser 
    2645                 2650                 2655             


Ile Tyr  Gln Ala Cys Ser Leu  Pro Glu Glu Ala Arg  Thr Ala Ile 
    2660                 2665                 2670             


His Ser  Leu Thr Glu Arg Leu  Tyr Val Gly Gly Pro  Met Phe Asn 
    2675                 2680                 2685             


Ser Lys  Gly Gln Thr Cys Gly  Tyr Arg Arg Cys Arg  Ala Ser Gly 
    2690                 2695                 2700             


Val Leu  Thr Thr Ser Met Gly  Asn Thr Ile Thr Cys  Tyr Val Lys 
    2705                 2710                 2715             


Ala Leu  Ala Ala Cys Lys Ala  Ala Gly Ile Val Ala  Pro Thr Met 
    2720                 2725                 2730             


Leu Val  Cys Gly Asp Asp Leu  Val Val Ile Ser Glu  Ser Gln Gly 
    2735                 2740                 2745             


Thr Glu  Glu Asp Glu Arg Asn  Leu Arg Ala Phe Thr  Glu Ala Met 
    2750                 2755                 2760             


Thr Arg  Tyr Ser Ala Pro Pro  Gly Asp Pro Pro Arg  Pro Glu Tyr 
    2765                 2770                 2775             


Asp Leu  Glu Leu Ile Thr Ser  Cys Ser Ser Asn Val  Ser Val Ala 
    2780                 2785                 2790             


Leu Gly  Pro Arg Gly Arg Arg  Arg Tyr Tyr Leu Thr  Arg Asp Pro 
    2795                 2800                 2805             


Thr Thr  Pro Leu Ala Arg Ala  Ala Trp Glu Thr Val  Arg His Ser 
    2810                 2815                 2820             


Pro Ile  Asn Ser Trp Leu Gly  Asn Ile Ile Gln Tyr  Ala Pro Thr 
    2825                 2830                 2835             


Ile Trp  Val Arg Met Val Leu  Met Thr His Phe Phe  Ser Ile Leu 
    2840                 2845                 2850             


Met Val  Gln Asp Thr Leu Asp  Gln Asn Leu Asn Phe  Glu Met Tyr 
    2855                 2860                 2865             


Gly Ser  Val Tyr Ser Val Asn  Pro Leu Asp Leu Pro  Ala Ile Ile 
    2870                 2875                 2880             


Glu Arg  Leu His Gly Leu Asp  Ala Phe Ser Met His  Thr Tyr Ser 
    2885                 2890                 2895             


His His  Glu Leu Thr Arg Val  Ala Ser Ala Leu Arg  Lys Leu Gly 
    2900                 2905                 2910             


Ala Pro  Pro Leu Arg Val Trp  Lys Ser Arg Ala Arg  Ala Val Arg 
    2915                 2920                 2925             


Ala Ser  Leu Ile Ser Arg Gly  Gly Lys Ala Ala Val  Cys Gly Arg 
    2930                 2935                 2940             


Tyr Leu  Phe Asn Trp Ala Val  Lys Thr Lys Leu Lys  Leu Thr Pro 
    2945                 2950                 2955             


Leu Pro  Glu Ala Arg Leu Leu  Asp Leu Ser Ser Trp  Phe Thr Val 
    2960                 2965                 2970             


Gly Ala  Gly Gly Gly Gly Ile  Phe His Ser Val Ser  Arg Ala Arg 
    2975                 2980                 2985             


Pro Arg  Ser Leu Leu Phe Gly  Leu Leu Leu Leu Phe  Val Gly Val 
    2990                 2995                 3000             


Gly Leu  Phe Leu Leu Pro Ala  Arg 
    3005                 3010     


<210>  149
<211>  3011
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  plasmid

<400>  149

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Gly Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Thr Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Phe Glu Ala Ala Asp Ala Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Val Thr Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Thr Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Ser Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Ala Leu Leu Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Met Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr Tyr Val Thr Gly Gly Ser Ala Ala Arg Thr Thr Ala Gly Leu Ala 
385                 390                 395                 400 


Ser Leu Phe Ser Pro Gly Ala Lys Gln Asn Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Asn Thr Gly Trp Ile Ala Gly Leu Phe Tyr His His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Ser Glu Arg Leu Ala Ser Cys Arg Pro Leu Thr Asp 
    450                 455                 460                 


Phe Ala Gln Gly Trp Gly Pro Ile Ser His Ala Asp Gly Ser Gly Pro 
465                 470                 475                 480 


Asp Gln Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Lys Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly Ala Pro Thr Tyr Ser 
        515                 520                 525             


Trp Gly Ala Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu Arg Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Ile Asn Tyr 
    610                 615                 620                 


Thr Val Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Glu Ala Ala Cys Asn Trp Thr Arg Gly Asp Arg Cys Asn Leu Asp Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Ile Ala Ser Trp Ala Ile Lys Trp Glu Tyr Val Val 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Val Glu Ala Ala Leu Glu Asn Leu Val 
            740                 745                 750         


Val Leu Asn Ala Ala Ser Leu Ala Gly Thr His Gly Leu Val Ser Phe 
        755                 760                 765             


Leu Val Phe Phe Cys Phe Ala Trp Tyr Leu Lys Gly Lys Trp Val Pro 
    770                 775                 780                 


Gly Ala Val Tyr Ala Leu Tyr Gly Met Trp Pro Leu Leu Leu Leu Leu 
785                 790                 795                 800 


Leu Ala Leu Pro Gln Arg Ala Tyr Ala Leu Asp Thr Glu Val Ala Ala 
                805                 810                 815     


Ser Cys Gly Gly Val Val Leu Val Gly Leu Met Ala Leu Thr Leu Ser 
            820                 825                 830         


Pro Tyr Tyr Lys Arg Tyr Ile Ser Trp Cys Leu Trp Trp Leu Gln Tyr 
        835                 840                 845             


Phe Leu Thr Arg Ile Glu Ala Gln Leu His Val Trp Ile Pro Pro Leu 
    850                 855                 860                 


Asn Val Arg Gly Gly Arg Asp Ala Val Ile Leu Leu Met Cys Val Val 
865                 870                 875                 880 


His Pro Ala Leu Val Phe Asp Ile Thr Lys Leu Leu Leu Ala Ala Phe 
                885                 890                 895     


Gly Pro Leu Trp Ile Leu Gln Ala Ser Leu Leu Lys Val Pro Tyr Phe 
            900                 905                 910         


Val Arg Val Gln Gly Leu Leu Arg Ile Cys Ala Leu Ala Arg Lys Met 
        915                 920                 925             


Ala Gly Gly His Tyr Val Gln Met Ala Ile Ile Lys Leu Gly Ala Leu 
    930                 935                 940                 


Thr Gly Thr Tyr Val Tyr Asn His Leu Thr Pro Leu Arg Asp Trp Ala 
945                 950                 955                 960 


His Asn Gly Leu Arg Asp Leu Ala Val Ala Val Glu Pro Val Val Phe 
                965                 970                 975     


Ser Arg Met Glu Thr Lys Leu Ile Thr Trp Gly Ala Asp Thr Ala Ala 
            980                 985                 990         


Cys Gly Asp Ile Ile Asn Gly Leu  Pro Val Ser Ala Arg  Arg Gly Arg 
        995                 1000                 1005             


Glu Ile  Leu Leu Gly Pro Ala  Asp Gly Met Val Ser  Lys Gly Trp 
    1010                 1015                 1020             


Arg Leu  Leu Ala Pro Ile Thr  Ala Tyr Ala Gln Gln  Thr Arg Gly 
    1025                 1030                 1035             


Leu Leu  Gly Cys Ile Ile Thr  Ser Leu Thr Gly Arg  Asp Lys Asn 
    1040                 1045                 1050             


Gln Val  Glu Gly Glu Ile Gln  Ile Val Ser Thr Ala  Ala Gln Thr 
    1055                 1060                 1065             


Phe Leu  Ala Thr Cys Ile Asn  Gly Val Cys Trp Thr  Val Tyr His 
    1070                 1075                 1080             


Gly Ala  Gly Thr Arg Thr Ile  Ala Ser Pro Lys Gly  Pro Val Ile 
    1085                 1090                 1095             


Gln Met  Tyr Thr Asn Val Asp  Lys Asp Leu Val Gly  Trp Pro Ala 
    1100                 1105                 1110             


Pro Gln  Gly Ala Arg Ser Leu  Thr Pro Cys Thr Cys  Gly Ser Ser 
    1115                 1120                 1125             


Asp Leu  Tyr Leu Val Thr Arg  His Ala Asp Val Ile  Pro Val Arg 
    1130                 1135                 1140             


Arg Arg  Gly Asp Ser Arg Gly  Ser Leu Leu Ser Pro  Arg Pro Ile 
    1145                 1150                 1155             


Ser Tyr  Leu Lys Gly Ser Ser  Gly Gly Pro Leu Leu  Cys Pro Ala 
    1160                 1165                 1170             


Gly His  Ala Val Gly Leu Phe  Arg Ala Ala Val Cys  Thr Arg Gly 
    1175                 1180                 1185             


Val Ala  Lys Ala Val Asp Phe  Ile Pro Val Glu Asn  Leu Glu Thr 
    1190                 1195                 1200             


Thr Met  Arg Ser Pro Val Phe  Thr Asp Asn Ser Ser  Pro Pro Ala 
    1205                 1210                 1215             


Val Pro  Gln Ser Phe Gln Val  Gly His Leu His Ala  Pro Thr Gly 
    1220                 1225                 1230             


Ser Gly  Lys Ser Thr Lys Val  Pro Ala Ala Tyr Ala  Ala Gln Gly 
    1235                 1240                 1245             


Tyr Lys  Val Leu Val Leu Asn  Pro Ser Val Ala Ala  Thr Leu Gly 
    1250                 1255                 1260             


Phe Gly  Ala Tyr Met Ser Lys  Ala His Gly Val Asp  Pro Asn Ile 
    1265                 1270                 1275             


Arg Thr  Gly Val Arg Thr Ile  Thr Thr Gly Ser Pro  Ile Thr Tyr 
    1280                 1285                 1290             


Ser Thr  Tyr Gly Lys Phe Leu  Ala Asp Gly Gly Cys  Ser Gly Gly 
    1295                 1300                 1305             


Ala Tyr  Asp Ile Ile Ile Cys  Asp Glu Cys His Ser  Thr Asp Ala 
    1310                 1315                 1320             


Thr Ser  Ile Leu Gly Ile Gly  Thr Val Leu Asp Gln  Ala Glu Thr 
    1325                 1330                 1335             


Ala Gly  Ala Arg Leu Val Val  Leu Ala Thr Ala Thr  Pro Pro Gly 
    1340                 1345                 1350             


Ser Ile  Thr Val Pro His Pro  Asn Ile Glu Glu Val  Ala Leu Ser 
    1355                 1360                 1365             


Thr Thr  Gly Glu Ile Pro Phe  Tyr Gly Lys Ala Ile  Pro Leu Glu 
    1370                 1375                 1380             


Ala Ile  Lys Gly Gly Arg His  Leu Ile Phe Cys His  Ser Lys Lys 
    1385                 1390                 1395             


Lys Cys  Asp Glu Leu Ala Ala  Lys Leu Val Ala Leu  Gly Ile Asn 
    1400                 1405                 1410             


Ala Val  Ala Tyr Tyr Arg Gly  Leu Asp Val Ser Val  Ile Pro Thr 
    1415                 1420                 1425             


Ser Gly  Asp Val Val Val Val  Ala Thr Asp Ala Leu  Met Thr Gly 
    1430                 1435                 1440             


Tyr Thr  Gly Asp Phe Asp Ser  Val Ile Asp Cys Asn  Thr Cys Val 
    1445                 1450                 1455             


Thr Gln  Thr Val Asp Leu Ser  Leu Asp Pro Thr Phe  Thr Ile Glu 
    1460                 1465                 1470             


Thr Thr  Thr Leu Pro Gln Asp  Ala Val Ser Arg Thr  Gln Arg Arg 
    1475                 1480                 1485             


Gly Arg  Thr Gly Arg Gly Lys  Pro Gly Ile Tyr Arg  Phe Val Ala 
    1490                 1495                 1500             


Leu Gly  Glu Arg Pro Ser Gly  Met Phe Asp Ser Ser  Val Leu Cys 
    1505                 1510                 1515             


Glu Cys  Tyr Asp Ala Gly Cys  Ala Trp Tyr Glu Leu  Thr Pro Ala 
    1520                 1525                 1530             


Glu Thr  Thr Val Arg Leu Arg  Ala Tyr Met Asn Thr  Pro Gly Leu 
    1535                 1540                 1545             


Pro Val  Cys Gln Asp His Leu  Glu Phe Trp Glu Gly  Val Phe Thr 
    1550                 1555                 1560             


Gly Leu  Thr His Ile Asp Ala  His Phe Leu Ser Gln  Thr Lys Gln 
    1565                 1570                 1575             


Ser Gly  Glu Asn Phe Pro Tyr  Leu Val Ala Tyr Gln  Ala Thr Val 
    1580                 1585                 1590             


Cys Ala  Arg Ala Gln Ala Pro  Pro Pro Ser Trp Asp  Gln Met Trp 
    1595                 1600                 1605             


Lys Cys  Leu Thr Arg Leu Lys  Pro Thr Leu His Gly  Pro Thr Pro 
    1610                 1615                 1620             


Leu Leu  Tyr Arg Leu Gly Ala  Val Gln Asn Glu Val  Thr Leu Thr 
    1625                 1630                 1635             


His Pro  Ile Thr Lys Tyr Ile  Met Thr Cys Met Ser  Ala Asp Leu 
    1640                 1645                 1650             


Glu Val  Val Thr Ser Thr Trp  Val Leu Val Gly Gly  Val Leu Ala 
    1655                 1660                 1665             


Ala Leu  Ala Ser Tyr Cys Leu  Ser Thr Gly Cys Val  Val Ile Val 
    1670                 1675                 1680             


Gly Arg  Ile Val Leu Ser Gly  Lys Pro Ala Ile Ile  Pro Asp Arg 
    1685                 1690                 1695             


Glu Val  Leu Tyr Arg Glu Phe  Asp Glu Met Glu Glu  Cys Ser Gln 
    1700                 1705                 1710             


His Leu  Pro Tyr Ile Glu Gln  Gly Met Met Leu Ala  Glu Gln Phe 
    1715                 1720                 1725             


Lys Gln  Lys Ala Leu Gly Leu  Leu Gln Thr Ala Ser  Arg Gln Ala 
    1730                 1735                 1740             


Glu Val  Val Ala Pro Ala Val  Gln Thr Asn Trp Gln  Lys Leu Glu 
    1745                 1750                 1755             


Ala Phe  Trp Ala Lys His Met  Trp Asn Phe Ile Ser  Gly Ile Gln 
    1760                 1765                 1770             


Tyr Leu  Ala Gly Leu Ser Thr  Leu Pro Gly Asn Pro  Ala Ile Ala 
    1775                 1780                 1785             


Ser Leu  Met Ala Phe Thr Ala  Ala Val Thr Ser Pro  Leu Thr Thr 
    1790                 1795                 1800             


Ser Gln  Thr Leu Leu Phe Asn  Ile Leu Gly Gly Trp  Val Ala Ala 
    1805                 1810                 1815             


Gln Leu  Ala Ala Pro Gly Ala  Ala Thr Ala Phe Val  Gly Ala Gly 
    1820                 1825                 1830             


Leu Ala  Gly Ala Ala Ile Gly  Ser Val Gly Leu Gly  Lys Val Leu 
    1835                 1840                 1845             


Val Asp  Ile Leu Ala Gly Tyr  Gly Ala Gly Val Ala  Gly Ala Leu 
    1850                 1855                 1860             


Val Ala  Phe Lys Ile Met Ser  Gly Glu Val Pro Ser  Thr Glu Asp 
    1865                 1870                 1875             


Leu Val  Asn Leu Leu Pro Ala  Ile Leu Ser Pro Gly  Ala Leu Val 
    1880                 1885                 1890             


Val Gly  Val Val Cys Ala Ala  Ile Leu Arg Arg His  Val Gly Pro 
    1895                 1900                 1905             


Gly Glu  Gly Ala Val Gln Trp  Met Asn Arg Leu Ile  Ala Phe Ala 
    1910                 1915                 1920             


Ser Arg  Gly Asn His Val Ser  Pro Thr His Tyr Val  Pro Glu Ser 
    1925                 1930                 1935             


Asp Ala  Ala Ala Arg Val Thr  Thr Ile Leu Ser Ser  Leu Thr Val 
    1940                 1945                 1950             


Thr Gln  Leu Leu Arg Arg Leu  His Gln Trp Ile Ser  Ser Glu Cys 
    1955                 1960                 1965             


Thr Thr  Pro Cys Ser Gly Ser  Trp Leu Arg Asp Ile  Trp Asp Trp 
    1970                 1975                 1980             


Ile Cys  Glu Val Leu Ser Asp  Phe Lys Thr Trp Leu  Lys Ala Lys 
    1985                 1990                 1995             


Leu Met  Pro Gln Leu Pro Gly  Ile Pro Phe Val Ser  Cys Gln Arg 
    2000                 2005                 2010             


Gly Tyr  Lys Gly Val Trp Arg  Gly Asp Gly Ile Met  His Thr Arg 
    2015                 2020                 2025             


Cys His  Cys Gly Ala Glu Ile  Thr Gly His Val Lys  Asn Gly Thr 
    2030                 2035                 2040             


Met Arg  Ile Val Gly Pro Lys  Thr Cys Arg Asn Met  Trp Ser Gly 
    2045                 2050                 2055             


Thr Phe  Pro Ile Asn Ala Tyr  Thr Thr Gly Pro Cys  Thr Pro Leu 
    2060                 2065                 2070             


Pro Ala  Pro Asn Tyr Thr Phe  Ala Leu Trp Arg Val  Ser Ala Glu 
    2075                 2080                 2085             


Glu Tyr  Val Glu Ile Arg Gln  Val Gly Asp Phe His  Tyr Val Thr 
    2090                 2095                 2100             


Gly Met  Thr Thr Asp Asn Leu  Lys Cys Pro Cys Gln  Val Pro Ser 
    2105                 2110                 2115             


Pro Glu  Phe Phe Thr Glu Leu  Asp Gly Val Arg Leu  His Arg Phe 
    2120                 2125                 2130             


Ala Pro  Pro Cys Lys Pro Leu  Leu Arg Glu Glu Val  Ser Phe Arg 
    2135                 2140                 2145             


Val Gly  Leu His Glu Tyr Pro  Val Gly Ser Gln Leu  Pro Cys Glu 
    2150                 2155                 2160             


Pro Glu  Pro Asp Val Ala Val  Leu Thr Ser Met Leu  Thr Asp Pro 
    2165                 2170                 2175             


Ser His  Ile Thr Ala Glu Ala  Ala Gly Arg Arg Leu  Ala Arg Gly 
    2180                 2185                 2190             


Ser Pro  Pro Ser Met Ala Ser  Ser Ser Ala Ser Gln  Leu Ser Ala 
    2195                 2200                 2205             


Pro Ser  Leu Arg Ala Thr Cys  Thr Thr Asn His Asp  Ser Pro Asp 
    2210                 2215                 2220             


Ala Glu  Leu Ile Glu Ala Asn  Leu Leu Trp Arg Gln  Glu Met Gly 
    2225                 2230                 2235             


Gly Asn  Ile Thr Arg Val Glu  Ser Glu Asn Lys Val  Val Ile Leu 
    2240                 2245                 2250             


Asp Ser  Phe Asp Pro Leu Val  Ala Glu Glu Asp Glu  Arg Glu Val 
    2255                 2260                 2265             


Ser Val  Pro Ala Glu Ile Leu  Arg Lys Ser Arg Lys  Phe Thr Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ile Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Pro  Trp Lys Lys Pro Asp  Tyr Glu Pro Pro Val  Val His Gly 
    2300                 2305                 2310             


Cys Pro  Leu Pro Pro Pro Gln  Ser Pro Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Lys Lys  Arg Thr Val Ile Leu  Thr Glu Ser Thr Leu  Pro Thr Ala 
    2330                 2335                 2340             


Leu Ala  Glu Leu Ala Thr Lys  Ser Phe Gly Ser Ser  Ser Thr Ser 
    2345                 2350                 2355             


Gly Ile  Thr Gly Asp Asp Thr  Thr Thr Ser Pro Glu  Pro Ala Ser 
    2360                 2365                 2370             


Ser Ser  Cys Pro Pro Asp Ser  Asp Ala Glu Ser Tyr  Ser Ser Met 
    2375                 2380                 2385             


Pro Pro  Leu Glu Gly Glu Pro  Gly Asp Pro Asp Leu  Ser Asp Gly 
    2390                 2395                 2400             


Ser Trp  Ser Thr Val Ser Ser  Glu Ala Asp Lys Glu  Asp Val Val 
    2405                 2410                 2415             


Cys Cys  Ser Met Ser Tyr Ser  Trp Thr Gly Ala Leu  Ile Thr Pro 
    2420                 2425                 2430             


Cys Ser  Pro Glu Glu Glu Lys  Leu Pro Ile Asn Pro  Leu Ser Asn 
    2435                 2440                 2445             


Ser Leu  Leu Arg Tyr His Asn  Lys Val Tyr Cys Thr  Thr Ser Lys 
    2450                 2455                 2460             


Ser Ala  Ser Gln Arg Ala Lys  Lys Val Thr Phe Asp  Arg Thr Gln 
    2465                 2470                 2475             


Val Leu  Asp Ala His Tyr Asp  Ser Val Leu Lys Asp  Ile Lys Leu 
    2480                 2485                 2490             


Ala Ala  Ser Lys Val Ser Ala  Arg Leu Leu Thr Leu  Glu Glu Ala 
    2495                 2500                 2505             


Cys Gln  Leu Thr Pro Pro His  Ser Ala Arg Ser Lys  Tyr Gly Phe 
    2510                 2515                 2520             


Gly Ala  Lys Glu Val Arg Ser  Leu Ser Gly Arg Ala  Val Asn His 
    2525                 2530                 2535             


Ile Lys  Ser Val Trp Lys Asp  Leu Leu Glu Asp Pro  Gln Thr Pro 
    2540                 2545                 2550             


Ile Pro  Thr Thr Ile Met Ala  Lys Asn Glu Val Phe  Cys Val Asp 
    2555                 2560                 2565             


Pro Ala  Lys Gly Gly Lys Lys  Pro Ala Arg Leu Ile  Val Tyr Pro 
    2570                 2575                 2580             


Asp Leu  Gly Val Arg Val Cys  Glu Lys Met Ala Leu  Tyr Asp Ile 
    2585                 2590                 2595             


Thr Gln  Lys Leu Pro Gln Ala  Val Met Gly Ala Ser  Tyr Gly Phe 
    2600                 2605                 2610             


Gln Tyr  Ser Pro Ala Gln Arg  Val Glu Tyr Leu Leu  Lys Ala Trp 
    2615                 2620                 2625             


Ala Glu  Lys Lys Asp Pro Met  Gly Phe Ser Tyr Asp  Thr Arg Cys 
    2630                 2635                 2640             


Phe Asp  Ser Thr Val Thr Glu  Arg Asp Ile Arg Thr  Glu Glu Ser 
    2645                 2650                 2655             


Ile Tyr  Gln Ala Cys Ser Leu  Pro Glu Glu Ala Arg  Thr Ala Ile 
    2660                 2665                 2670             


His Ser  Leu Thr Glu Arg Leu  Tyr Val Gly Gly Pro  Met Phe Asn 
    2675                 2680                 2685             


Ser Lys  Gly Gln Thr Cys Gly  Tyr Arg Arg Cys Arg  Ala Ser Gly 
    2690                 2695                 2700             


Val Leu  Thr Thr Ser Met Gly  Asn Thr Ile Thr Cys  Tyr Val Lys 
    2705                 2710                 2715             


Ala Leu  Ala Ala Cys Lys Ala  Ala Gly Ile Val Ala  Pro Thr Met 
    2720                 2725                 2730             


Leu Val  Cys Gly Asp Asp Leu  Val Val Ile Ser Glu  Ser Gln Gly 
    2735                 2740                 2745             


Thr Glu  Glu Asp Glu Arg Asn  Leu Arg Ala Phe Thr  Glu Ala Met 
    2750                 2755                 2760             


Thr Arg  Tyr Ser Ala Pro Pro  Gly Asp Pro Pro Arg  Pro Glu Tyr 
    2765                 2770                 2775             


Asp Leu  Glu Leu Ile Thr Ser  Cys Ser Ser Asn Val  Ser Val Ala 
    2780                 2785                 2790             


Leu Gly  Pro Arg Gly Arg Arg  Arg Tyr Tyr Leu Thr  Arg Asp Pro 
    2795                 2800                 2805             


Thr Thr  Pro Leu Ala Arg Ala  Ala Trp Glu Thr Val  Arg His Ser 
    2810                 2815                 2820             


Pro Ile  Asn Ser Trp Leu Gly  Asn Ile Ile Gln Tyr  Ala Pro Thr 
    2825                 2830                 2835             


Ile Trp  Val Arg Met Val Leu  Met Thr His Phe Phe  Ser Ile Leu 
    2840                 2845                 2850             


Met Val  Gln Asp Thr Leu Asp  Gln Asn Leu Asn Phe  Glu Met Tyr 
    2855                 2860                 2865             


Gly Ser  Val Tyr Ser Val Asn  Pro Leu Asp Leu Pro  Ala Ile Ile 
    2870                 2875                 2880             


Glu Arg  Leu His Gly Leu Asp  Ala Phe Ser Met His  Thr Tyr Ser 
    2885                 2890                 2895             


His His  Glu Leu Thr Arg Val  Ala Ser Ala Leu Arg  Lys Leu Gly 
    2900                 2905                 2910             


Ala Pro  Pro Leu Arg Val Trp  Lys Ser Arg Ala Arg  Ala Val Arg 
    2915                 2920                 2925             


Ala Ser  Leu Ile Ser Arg Gly  Gly Lys Ala Ala Val  Cys Gly Arg 
    2930                 2935                 2940             


Tyr Leu  Phe Asn Trp Ala Val  Lys Thr Lys Leu Lys  Leu Thr Pro 
    2945                 2950                 2955             


Leu Pro  Glu Ala Arg Leu Leu  Asp Leu Ser Ser Trp  Phe Thr Val 
    2960                 2965                 2970             


Gly Ala  Gly Gly Gly Gly Ile  Phe His Ser Val Ser  Arg Ala Arg 
    2975                 2980                 2985             


Pro Arg  Ser Leu Leu Phe Gly  Leu Leu Leu Leu Phe  Val Gly Val 
    2990                 2995                 3000             


Gly Leu  Phe Leu Leu Pro Ala  Arg 
    3005                 3010     


<210>  150
<211>  3011
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  plasmid

<400>  150

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Gly Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Thr Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Phe Glu Ala Ala Asp Ala Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Val Thr Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Thr Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Ser Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Ala Leu Leu Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Met Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr Tyr Val Thr Gly Gly Ser Ala Ala Arg Thr Thr Ala Gly Leu Ala 
385                 390                 395                 400 


Ser Leu Phe Ser Pro Gly Ala Lys Gln Asn Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Asn Thr Gly Trp Ile Ala Gly Leu Phe Tyr His His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Ser Glu Arg Leu Ala Ser Cys Arg Pro Leu Thr Asp 
    450                 455                 460                 


Phe Ala Gln Gly Trp Gly Pro Ile Ser His Ala Asp Gly Ser Gly Pro 
465                 470                 475                 480 


Asp Gln Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Lys Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly Ala Pro Thr Tyr Ser 
        515                 520                 525             


Trp Gly Ala Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu Arg Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Ile Asn Tyr 
    610                 615                 620                 


Thr Val Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Glu Ala Ala Cys Asn Trp Thr Arg Gly Asp Arg Cys Asn Leu Asp Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Ile Ala Ser Trp Ala Ile Lys Trp Glu Tyr Val Val 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Val Glu Ala Ala Leu Glu Asn Leu Val 
            740                 745                 750         


Val Leu Asn Ala Ala Ser Leu Ala Gly Thr His Gly Leu Val Ser Phe 
        755                 760                 765             


Leu Val Phe Phe Cys Phe Ala Trp Tyr Leu Lys Gly Lys Trp Val Pro 
    770                 775                 780                 


Gly Ala Val Tyr Ala Leu Tyr Gly Met Trp Pro Leu Leu Leu Leu Leu 
785                 790                 795                 800 


Leu Ala Leu Pro Gln Arg Ala Tyr Ala Leu Asp Thr Glu Val Ala Ala 
                805                 810                 815     


Ser Cys Gly Gly Val Val Leu Val Gly Leu Met Ala Leu Thr Leu Ser 
            820                 825                 830         


Pro Tyr Tyr Lys Arg Tyr Ile Ser Trp Cys Leu Trp Trp Leu Gln Tyr 
        835                 840                 845             


Phe Leu Thr Arg Ile Glu Ala Gln Leu His Val Trp Ile Pro Pro Leu 
    850                 855                 860                 


Asn Val Arg Gly Gly Arg Asp Ala Val Ile Leu Leu Met Cys Val Val 
865                 870                 875                 880 


His Pro Ala Leu Val Phe Asp Ile Thr Lys Leu Leu Leu Ala Ala Phe 
                885                 890                 895     


Gly Pro Leu Trp Ile Leu Gln Ala Ser Leu Leu Lys Val Pro Tyr Phe 
            900                 905                 910         


Val Arg Val Gln Gly Leu Leu Arg Ile Cys Ala Leu Ala Arg Lys Met 
        915                 920                 925             


Ala Gly Gly His Tyr Val Gln Met Ala Ile Ile Lys Leu Gly Ala Leu 
    930                 935                 940                 


Thr Gly Thr Tyr Val Tyr Asn His Leu Thr Pro Leu Arg Asp Trp Ala 
945                 950                 955                 960 


His Asn Gly Leu Arg Asp Leu Ala Val Ala Val Glu Pro Val Val Phe 
                965                 970                 975     


Ser Arg Met Glu Thr Lys Leu Ile Thr Trp Gly Ala Asp Thr Ala Ala 
            980                 985                 990         


Cys Gly Asp Ile Ile Asn Gly Leu  Pro Val Ser Ala Arg  Arg Gly Arg 
        995                 1000                 1005             


Glu Ile  Leu Leu Gly Pro Ala  Asp Gly Met Val Ser  Lys Gly Trp 
    1010                 1015                 1020             


Arg Leu  Leu Ala Pro Ile Thr  Ala Tyr Ala Gln Gln  Thr Arg Gly 
    1025                 1030                 1035             


Leu Leu  Gly Cys Ile Ile Thr  Ser Leu Thr Gly Arg  Asp Lys Asn 
    1040                 1045                 1050             


Gln Val  Glu Gly Glu Ile Gln  Ile Val Ser Thr Ala  Ala Gln Thr 
    1055                 1060                 1065             


Phe Leu  Ala Thr Cys Ile Asn  Gly Val Cys Trp Thr  Val Tyr His 
    1070                 1075                 1080             


Gly Ala  Gly Thr Arg Thr Ile  Ala Ser Pro Lys Gly  Pro Val Ile 
    1085                 1090                 1095             


Gln Met  Tyr Thr Asn Val Asp  Lys Asp Leu Val Gly  Trp Pro Ala 
    1100                 1105                 1110             


Pro Gln  Gly Ala Arg Ser Leu  Thr Pro Cys Thr Cys  Gly Ser Ser 
    1115                 1120                 1125             


Asp Leu  Tyr Leu Val Thr Arg  His Ala Asp Val Ile  Pro Val Arg 
    1130                 1135                 1140             


Arg Arg  Gly Asp Ser Arg Gly  Ser Leu Leu Ser Pro  Arg Pro Ile 
    1145                 1150                 1155             


Ser Tyr  Leu Lys Gly Ser Ser  Gly Gly Pro Leu Leu  Cys Pro Ala 
    1160                 1165                 1170             


Gly His  Ala Val Gly Leu Phe  Arg Ala Ala Val Cys  Thr Arg Gly 
    1175                 1180                 1185             


Val Ala  Lys Ala Val Asp Phe  Ile Pro Val Glu Asn  Leu Glu Thr 
    1190                 1195                 1200             


Thr Met  Arg Ser Pro Val Phe  Thr Asp Asn Ser Ser  Pro Pro Ala 
    1205                 1210                 1215             


Val Pro  Gln Ser Phe Gln Val  Ala His Leu His Ala  Pro Thr Gly 
    1220                 1225                 1230             


Ser Gly  Lys Ser Thr Lys Val  Pro Ala Ala Tyr Ala  Ala Gln Gly 
    1235                 1240                 1245             


Tyr Lys  Val Leu Val Leu Asn  Pro Ser Val Ala Ala  Thr Leu Gly 
    1250                 1255                 1260             


Phe Gly  Ala Tyr Met Ser Lys  Ala His Gly Val Asp  Pro Asn Ile 
    1265                 1270                 1275             


Arg Thr  Gly Val Arg Thr Ile  Thr Thr Gly Ser Pro  Ile Thr Tyr 
    1280                 1285                 1290             


Ser Thr  Tyr Gly Lys Phe Leu  Ala Asp Gly Gly Cys  Ser Gly Gly 
    1295                 1300                 1305             


Ala Tyr  Asp Ile Ile Ile Cys  Asp Glu Cys His Ser  Thr Asp Ala 
    1310                 1315                 1320             


Thr Ser  Ile Leu Gly Ile Gly  Thr Val Leu Asp Gln  Ala Glu Thr 
    1325                 1330                 1335             


Ala Gly  Ala Arg Leu Val Val  Leu Ala Thr Ala Thr  Pro Pro Gly 
    1340                 1345                 1350             


Ser Ile  Thr Val Pro His Pro  Asn Ile Glu Glu Val  Ala Leu Ser 
    1355                 1360                 1365             


Thr Thr  Gly Glu Ile Pro Phe  Tyr Gly Lys Ala Ile  Pro Leu Glu 
    1370                 1375                 1380             


Ala Ile  Lys Gly Gly Arg His  Leu Ile Phe Cys His  Ser Lys Lys 
    1385                 1390                 1395             


Lys Cys  Asp Glu Leu Ala Ala  Lys Leu Val Ala Leu  Gly Ile Asn 
    1400                 1405                 1410             


Ala Val  Ala Tyr Tyr Arg Gly  Leu Asp Val Ser Val  Ile Pro Thr 
    1415                 1420                 1425             


Ser Gly  Asp Val Val Val Val  Ala Thr Asp Ala Leu  Met Thr Gly 
    1430                 1435                 1440             


Tyr Thr  Gly Asp Phe Asp Ser  Val Ile Asp Cys Asn  Thr Cys Val 
    1445                 1450                 1455             


Thr Gln  Thr Val Asp Leu Ser  Leu Asp Pro Thr Phe  Thr Ile Glu 
    1460                 1465                 1470             


Thr Thr  Thr Leu Pro Gln Asp  Ala Val Ser Arg Thr  Gln Arg Arg 
    1475                 1480                 1485             


Gly Arg  Thr Gly Arg Gly Lys  Pro Gly Ile Tyr Arg  Phe Val Ala 
    1490                 1495                 1500             


Leu Gly  Glu Arg Pro Ser Gly  Met Phe Asp Ser Ser  Val Leu Cys 
    1505                 1510                 1515             


Glu Cys  Tyr Asp Ala Gly Cys  Ala Trp Tyr Glu Leu  Thr Pro Ala 
    1520                 1525                 1530             


Glu Thr  Thr Val Arg Leu Arg  Ala Tyr Met Asn Thr  Pro Gly Leu 
    1535                 1540                 1545             


Pro Val  Cys Gln Asp His Leu  Glu Phe Trp Glu Gly  Val Phe Thr 
    1550                 1555                 1560             


Gly Leu  Thr His Ile Asp Ala  His Phe Leu Ser Gln  Thr Lys Gln 
    1565                 1570                 1575             


Ser Gly  Glu Asn Phe Pro Tyr  Leu Val Ala Tyr Gln  Ala Thr Val 
    1580                 1585                 1590             


Cys Ala  Arg Ala Gln Ala Pro  Pro Pro Ser Trp Asp  Gln Met Trp 
    1595                 1600                 1605             


Lys Cys  Leu Thr Arg Leu Lys  Pro Thr Leu His Gly  Pro Thr Pro 
    1610                 1615                 1620             


Leu Leu  Tyr Arg Leu Gly Ala  Val Gln Asn Glu Val  Thr Leu Thr 
    1625                 1630                 1635             


His Pro  Ile Thr Lys Tyr Ile  Met Thr Cys Met Ser  Ala Asp Leu 
    1640                 1645                 1650             


Glu Val  Val Thr Ser Thr Trp  Val Leu Val Gly Gly  Val Leu Ala 
    1655                 1660                 1665             


Ala Leu  Ala Ser Tyr Cys Leu  Ser Thr Gly Cys Val  Val Ile Val 
    1670                 1675                 1680             


Gly Arg  Ile Val Leu Ser Gly  Lys Pro Ala Ile Ile  Pro Asp Arg 
    1685                 1690                 1695             


Glu Val  Leu Tyr Arg Glu Phe  Asp Glu Met Glu Glu  Cys Ser Gln 
    1700                 1705                 1710             


His Leu  Pro Tyr Ile Glu Gln  Gly Met Met Leu Ala  Glu Gln Phe 
    1715                 1720                 1725             


Lys Gln  Lys Ala Leu Gly Leu  Leu Gln Thr Ala Ser  Arg Gln Ala 
    1730                 1735                 1740             


Glu Val  Val Ala Pro Ala Val  Gln Thr Asn Trp Gln  Lys Leu Glu 
    1745                 1750                 1755             


Ala Phe  Trp Ala Lys His Met  Trp Asn Phe Ile Ser  Gly Ile His 
    1760                 1765                 1770             


Tyr Leu  Ala Gly Leu Ser Thr  Leu Pro Gly Asn Pro  Ala Ile Ala 
    1775                 1780                 1785             


Ser Leu  Met Ala Phe Thr Ala  Ala Val Thr Ser Pro  Leu Thr Thr 
    1790                 1795                 1800             


Ser Gln  Thr Leu Leu Phe Asn  Ile Leu Gly Gly Trp  Val Ala Ala 
    1805                 1810                 1815             


Gln Leu  Ala Ala Pro Gly Ala  Ala Thr Ala Phe Val  Gly Ala Gly 
    1820                 1825                 1830             


Leu Ala  Gly Ala Ala Ile Gly  Ser Val Gly Leu Gly  Lys Val Leu 
    1835                 1840                 1845             


Val Asp  Ile Leu Ala Gly Tyr  Gly Ala Gly Val Ala  Gly Ala Leu 
    1850                 1855                 1860             


Val Ala  Phe Lys Ile Met Ser  Gly Glu Val Pro Ser  Thr Glu Asp 
    1865                 1870                 1875             


Leu Val  Asn Leu Leu Pro Ala  Ile Leu Ser Pro Gly  Ala Leu Val 
    1880                 1885                 1890             


Val Gly  Val Val Cys Ala Ala  Ile Leu Arg Arg His  Val Gly Pro 
    1895                 1900                 1905             


Gly Glu  Gly Ala Val Gln Trp  Met Asn Arg Leu Ile  Ala Phe Ala 
    1910                 1915                 1920             


Ser Arg  Gly Asn His Val Ser  Pro Thr His Tyr Val  Pro Glu Ser 
    1925                 1930                 1935             


Asp Ala  Ala Ala Arg Val Thr  Thr Ile Leu Ser Ser  Leu Thr Val 
    1940                 1945                 1950             


Thr Gln  Leu Leu Arg Arg Leu  His Gln Trp Ile Ser  Ser Glu Cys 
    1955                 1960                 1965             


Thr Thr  Pro Cys Ser Gly Ser  Trp Leu Arg Asp Ile  Trp Asp Trp 
    1970                 1975                 1980             


Ile Cys  Glu Val Leu Ser Asp  Phe Lys Thr Trp Leu  Lys Ala Lys 
    1985                 1990                 1995             


Leu Met  Pro Gln Leu Pro Gly  Ile Pro Phe Val Ser  Cys Gln Arg 
    2000                 2005                 2010             


Gly Tyr  Lys Gly Val Trp Arg  Gly Asp Gly Ile Met  His Thr Arg 
    2015                 2020                 2025             


Cys His  Cys Gly Ala Glu Ile  Thr Gly His Val Lys  Asn Gly Thr 
    2030                 2035                 2040             


Met Arg  Ile Val Gly Pro Lys  Thr Cys Arg Asn Met  Trp Ser Gly 
    2045                 2050                 2055             


Thr Phe  Pro Ile Asn Ala Tyr  Thr Thr Gly Pro Cys  Thr Pro Leu 
    2060                 2065                 2070             


Pro Ala  Pro Asn Tyr Thr Phe  Ala Leu Trp Arg Val  Ser Ala Glu 
    2075                 2080                 2085             


Glu Tyr  Val Glu Ile Arg Gln  Val Gly Asp Phe His  Tyr Val Thr 
    2090                 2095                 2100             


Gly Met  Thr Thr Asp Asn Leu  Lys Cys Pro Cys Gln  Val Pro Ser 
    2105                 2110                 2115             


Pro Glu  Phe Phe Thr Glu Leu  Asp Gly Val Arg Leu  His Arg Phe 
    2120                 2125                 2130             


Ala Pro  Pro Cys Lys Pro Leu  Leu Arg Glu Glu Val  Ser Phe Arg 
    2135                 2140                 2145             


Val Gly  Leu His Glu Tyr Pro  Val Gly Ser Gln Leu  Pro Cys Glu 
    2150                 2155                 2160             


Pro Glu  Pro Asp Val Ala Val  Leu Thr Ser Met Leu  Thr Asp Pro 
    2165                 2170                 2175             


Ser His  Ile Thr Ala Glu Ala  Ala Gly Arg Arg Leu  Ala Arg Gly 
    2180                 2185                 2190             


Ser Pro  Pro Ser Met Ala Ser  Ser Ser Ala Ser Gln  Leu Ser Ala 
    2195                 2200                 2205             


Pro Ser  Leu Arg Ala Thr Cys  Thr Thr Asn His Asp  Ser Pro Asp 
    2210                 2215                 2220             


Ala Glu  Leu Ile Glu Ala Asn  Leu Leu Trp Arg Gln  Glu Met Gly 
    2225                 2230                 2235             


Gly Asn  Ile Thr Arg Val Glu  Ser Glu Asn Lys Val  Val Ile Leu 
    2240                 2245                 2250             


Asp Ser  Phe Asp Pro Leu Val  Ala Glu Glu Asp Glu  Arg Glu Val 
    2255                 2260                 2265             


Ser Val  Pro Ala Glu Ile Leu  Arg Lys Ser Arg Lys  Phe Thr Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ile Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Pro  Trp Lys Lys Pro Asp  Tyr Glu Pro Pro Val  Val His Gly 
    2300                 2305                 2310             


Cys Pro  Leu Pro Pro Pro Gln  Ser Pro Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Lys Lys  Arg Thr Val Ile Leu  Thr Glu Ser Thr Leu  Pro Thr Ala 
    2330                 2335                 2340             


Leu Ala  Glu Leu Ala Thr Lys  Ser Phe Gly Ser Ser  Ser Thr Ser 
    2345                 2350                 2355             


Gly Ile  Thr Gly Asp Asp Thr  Thr Thr Ser Pro Glu  Pro Ala Ser 
    2360                 2365                 2370             


Ser Ser  Cys Pro Pro Asp Ser  Asp Ala Glu Ser Tyr  Ser Ser Met 
    2375                 2380                 2385             


Pro Pro  Leu Glu Gly Glu Pro  Gly Asp Pro Asp Leu  Ser Asp Gly 
    2390                 2395                 2400             


Ser Trp  Ser Thr Val Ser Ser  Glu Ala Asp Lys Glu  Asp Val Val 
    2405                 2410                 2415             


Cys Cys  Ser Met Ser Tyr Ser  Trp Thr Gly Ala Leu  Ile Thr Pro 
    2420                 2425                 2430             


Cys Ser  Pro Glu Glu Glu Lys  Leu Pro Ile Asn Pro  Leu Ser Asn 
    2435                 2440                 2445             


Ser Leu  Leu Arg Tyr His Asn  Lys Val Tyr Cys Thr  Thr Ser Lys 
    2450                 2455                 2460             


Ser Ala  Ser Gln Arg Ala Lys  Lys Val Thr Phe Asp  Arg Thr Gln 
    2465                 2470                 2475             


Val Leu  Asp Ala His Tyr Asp  Ser Val Leu Lys Asp  Ile Lys Leu 
    2480                 2485                 2490             


Ala Ala  Ser Lys Val Ser Ala  Arg Leu Leu Thr Leu  Glu Glu Ala 
    2495                 2500                 2505             


Cys Gln  Leu Thr Pro Pro His  Ser Ala Arg Ser Lys  Tyr Gly Phe 
    2510                 2515                 2520             


Gly Ala  Lys Glu Val Arg Ser  Leu Ser Gly Arg Ala  Val Asn His 
    2525                 2530                 2535             


Ile Lys  Ser Val Trp Lys Asp  Leu Leu Glu Asp Pro  Gln Thr Pro 
    2540                 2545                 2550             


Ile Pro  Thr Thr Ile Met Ala  Lys Asn Glu Val Phe  Cys Val Asp 
    2555                 2560                 2565             


Pro Ala  Lys Gly Gly Lys Lys  Pro Ala Arg Leu Ile  Val Tyr Pro 
    2570                 2575                 2580             


Asp Leu  Gly Val Arg Val Cys  Glu Lys Met Ala Leu  Tyr Asp Ile 
    2585                 2590                 2595             


Thr Gln  Lys Leu Pro Gln Ala  Val Met Gly Ala Ser  Tyr Gly Phe 
    2600                 2605                 2610             


Gln Tyr  Ser Pro Ala Gln Arg  Val Glu Tyr Leu Leu  Lys Ala Trp 
    2615                 2620                 2625             


Ala Glu  Lys Lys Asp Pro Met  Gly Phe Ser Tyr Asp  Thr Arg Cys 
    2630                 2635                 2640             


Phe Asp  Ser Thr Val Thr Glu  Arg Asp Ile Arg Thr  Glu Glu Ser 
    2645                 2650                 2655             


Ile Tyr  Gln Ala Cys Ser Leu  Pro Glu Glu Ala Arg  Thr Ala Ile 
    2660                 2665                 2670             


His Ser  Leu Thr Glu Arg Leu  Tyr Val Gly Gly Pro  Met Phe Asn 
    2675                 2680                 2685             


Ser Lys  Gly Gln Thr Cys Gly  Tyr Arg Arg Cys Arg  Ala Ser Gly 
    2690                 2695                 2700             


Val Leu  Thr Thr Ser Met Gly  Asn Thr Ile Thr Cys  Tyr Val Lys 
    2705                 2710                 2715             


Ala Leu  Ala Ala Cys Lys Ala  Ala Gly Ile Val Ala  Pro Thr Met 
    2720                 2725                 2730             


Leu Val  Cys Gly Asp Asp Leu  Val Val Ile Ser Glu  Ser Gln Gly 
    2735                 2740                 2745             


Thr Glu  Glu Asp Glu Arg Asn  Leu Arg Ala Phe Thr  Glu Ala Met 
    2750                 2755                 2760             


Thr Arg  Tyr Ser Ala Pro Pro  Gly Asp Pro Pro Arg  Pro Glu Tyr 
    2765                 2770                 2775             


Asp Leu  Glu Leu Ile Thr Ser  Cys Ser Ser Asn Val  Ser Val Ala 
    2780                 2785                 2790             


Leu Gly  Pro Arg Gly Arg Arg  Arg Tyr Tyr Leu Thr  Arg Asp Pro 
    2795                 2800                 2805             


Thr Thr  Pro Leu Ala Arg Ala  Ala Trp Glu Thr Val  Arg His Ser 
    2810                 2815                 2820             


Pro Ile  Asn Ser Trp Leu Gly  Asn Ile Ile Gln Tyr  Ala Pro Thr 
    2825                 2830                 2835             


Ile Trp  Val Arg Met Val Leu  Met Thr His Phe Phe  Ser Ile Leu 
    2840                 2845                 2850             


Met Val  Gln Asp Thr Leu Asp  Gln Asn Leu Asn Phe  Glu Met Tyr 
    2855                 2860                 2865             


Gly Ser  Val Tyr Ser Val Asn  Pro Leu Asp Leu Pro  Ala Ile Ile 
    2870                 2875                 2880             


Glu Arg  Leu His Gly Leu Asp  Ala Phe Ser Met His  Thr Tyr Ser 
    2885                 2890                 2895             


His His  Glu Leu Thr Arg Val  Ala Ser Ala Leu Arg  Lys Leu Gly 
    2900                 2905                 2910             


Ala Pro  Pro Leu Arg Val Trp  Lys Ser Arg Ala Arg  Ala Val Arg 
    2915                 2920                 2925             


Ala Ser  Leu Ile Ser Arg Gly  Gly Lys Ala Ala Val  Cys Gly Arg 
    2930                 2935                 2940             


Tyr Leu  Phe Asn Trp Ala Val  Lys Thr Lys Leu Lys  Leu Thr Pro 
    2945                 2950                 2955             


Leu Pro  Glu Ala Arg Leu Leu  Asp Leu Ser Ser Trp  Phe Thr Val 
    2960                 2965                 2970             


Gly Ala  Gly Gly Gly Gly Ile  Phe His Ser Val Ser  Arg Ala Arg 
    2975                 2980                 2985             


Pro Arg  Ser Leu Leu Phe Gly  Leu Leu Leu Leu Phe  Val Gly Val 
    2990                 2995                 3000             


Gly Leu  Phe Leu Leu Pro Ala  Arg 
    3005                 3010     


<210>  151
<211>  3011
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  plasmid

<400>  151

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Gly Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Thr Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Phe Glu Ala Ala Asp Ala Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Val Thr Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Thr Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Ser Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Ala Leu Leu Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Met Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr Tyr Val Thr Gly Gly Ser Ala Ala Arg Thr Thr Ala Gly Leu Ala 
385                 390                 395                 400 


Ser Leu Phe Ser Pro Gly Ala Lys Gln Asn Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Asn Thr Gly Trp Ile Ala Gly Leu Phe Tyr His His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Ser Glu Arg Leu Ala Ser Cys Arg Pro Leu Thr Asp 
    450                 455                 460                 


Phe Ala Gln Gly Trp Gly Pro Ile Ser His Ala Asp Gly Ser Gly Pro 
465                 470                 475                 480 


Asp Gln Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Lys Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly Ala Pro Thr Tyr Ser 
        515                 520                 525             


Trp Gly Ala Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu Arg Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Ile Asn Tyr 
    610                 615                 620                 


Thr Val Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Glu Ala Ala Cys Asn Trp Thr Arg Gly Asp Arg Cys Asn Leu Asp Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Ile Ala Ser Trp Ala Ile Lys Trp Glu Tyr Val Val 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Val Glu Ala Ala Leu Glu Asn Leu Val 
            740                 745                 750         


Val Leu Asn Ala Ala Ser Leu Ala Gly Thr His Gly Leu Val Ser Phe 
        755                 760                 765             


Leu Val Phe Phe Cys Phe Ala Trp Tyr Leu Lys Gly Lys Trp Val Pro 
    770                 775                 780                 


Gly Ala Val Tyr Ala Leu Tyr Gly Met Trp Pro Leu Leu Leu Leu Leu 
785                 790                 795                 800 


Leu Ala Leu Pro Gln Arg Ala Tyr Ala Leu Asp Thr Glu Val Ala Ala 
                805                 810                 815     


Ser Cys Gly Gly Val Val Leu Val Gly Leu Met Ala Leu Thr Leu Ser 
            820                 825                 830         


Pro Tyr Tyr Lys Arg Tyr Ile Ser Trp Cys Leu Trp Trp Leu Gln Tyr 
        835                 840                 845             


Phe Leu Thr Arg Ile Glu Ala Gln Leu His Val Trp Ile Pro Pro Leu 
    850                 855                 860                 


Asn Val Arg Gly Gly Arg Asp Ala Val Ile Leu Leu Met Cys Val Val 
865                 870                 875                 880 


His Pro Ala Leu Val Phe Asp Ile Thr Lys Leu Leu Leu Ala Ala Phe 
                885                 890                 895     


Gly Pro Leu Trp Ile Leu Gln Ala Ser Leu Leu Lys Val Pro Tyr Phe 
            900                 905                 910         


Val Arg Val Gln Gly Leu Leu Arg Ile Cys Ala Leu Ala Arg Lys Met 
        915                 920                 925             


Ala Gly Gly His Tyr Val Gln Met Ala Ile Ile Lys Leu Gly Ala Leu 
    930                 935                 940                 


Thr Gly Thr Tyr Val Tyr Asn His Leu Thr Pro Leu Arg Asp Trp Ala 
945                 950                 955                 960 


His Asn Gly Leu Arg Asp Leu Ala Val Ala Val Glu Pro Val Val Phe 
                965                 970                 975     


Ser Arg Met Glu Thr Lys Leu Ile Thr Trp Gly Ala Asp Thr Ala Ala 
            980                 985                 990         


Cys Gly Asp Ile Ile Asn Gly Leu  Pro Val Ser Ala Arg  Arg Gly Arg 
        995                 1000                 1005             


Glu Ile  Leu Leu Gly Pro Ala  Asp Gly Met Val Ser  Lys Gly Trp 
    1010                 1015                 1020             


Arg Leu  Leu Ala Pro Ile Thr  Ala Tyr Ala Gln Gln  Thr Arg Gly 
    1025                 1030                 1035             


Leu Leu  Gly Cys Ile Ile Thr  Ser Leu Thr Gly Arg  Asp Lys Asn 
    1040                 1045                 1050             


Gln Val  Glu Gly Glu Ile Gln  Ile Val Ser Thr Ala  Ala Gln Thr 
    1055                 1060                 1065             


Phe Leu  Ala Thr Cys Ile Asn  Gly Val Cys Trp Thr  Val Tyr His 
    1070                 1075                 1080             


Gly Ala  Gly Thr Arg Thr Ile  Ala Ser Pro Lys Gly  Pro Val Ile 
    1085                 1090                 1095             


Gln Met  Tyr Thr Asn Val Asp  Lys Asp Leu Val Gly  Trp Pro Ala 
    1100                 1105                 1110             


Pro Gln  Gly Ala Arg Ser Leu  Thr Pro Cys Thr Cys  Gly Ser Ser 
    1115                 1120                 1125             


Asp Leu  Tyr Leu Val Thr Arg  His Ala Asp Val Ile  Pro Val Arg 
    1130                 1135                 1140             


Arg Arg  Gly Asp Ser Arg Gly  Ser Leu Leu Ser Pro  Arg Pro Ile 
    1145                 1150                 1155             


Ser Tyr  Leu Lys Gly Ser Ser  Gly Gly Pro Leu Leu  Cys Pro Ala 
    1160                 1165                 1170             


Gly His  Ala Val Gly Leu Phe  Arg Ala Ala Val Cys  Thr Arg Gly 
    1175                 1180                 1185             


Val Ala  Lys Ala Val Asp Phe  Ile Pro Val Glu Asn  Leu Glu Thr 
    1190                 1195                 1200             


Thr Met  Arg Ser Pro Val Phe  Thr Asp Asn Ser Ser  Pro Pro Ala 
    1205                 1210                 1215             


Val Pro  Gln Ser Phe Gln Val  Ala His Leu His Ala  Pro Thr Gly 
    1220                 1225                 1230             


Ser Gly  Lys Ser Thr Lys Val  Pro Ala Ala Tyr Ala  Ala Gln Gly 
    1235                 1240                 1245             


Tyr Lys  Val Leu Val Leu Asn  Pro Ser Val Ala Ala  Thr Leu Gly 
    1250                 1255                 1260             


Phe Gly  Ala Tyr Met Ser Lys  Ala His Gly Val Asp  Pro Asn Ile 
    1265                 1270                 1275             


Arg Thr  Gly Val Arg Thr Ile  Thr Thr Gly Ser Pro  Ile Thr Tyr 
    1280                 1285                 1290             


Ser Thr  Tyr Gly Lys Phe Leu  Ala Asp Gly Gly Cys  Ser Gly Gly 
    1295                 1300                 1305             


Ala Tyr  Asp Ile Ile Ile Cys  Asp Glu Cys His Ser  Thr Asp Ala 
    1310                 1315                 1320             


Thr Ser  Ile Leu Gly Ile Gly  Thr Val Leu Asp Gln  Ala Glu Thr 
    1325                 1330                 1335             


Ala Gly  Ala Arg Leu Val Val  Leu Ala Thr Ala Thr  Pro Pro Gly 
    1340                 1345                 1350             


Ser Ile  Thr Val Pro His Pro  Asn Ile Glu Glu Val  Ala Leu Ser 
    1355                 1360                 1365             


Thr Thr  Gly Glu Ile Pro Phe  Tyr Gly Lys Ala Ile  Pro Leu Glu 
    1370                 1375                 1380             


Ala Ile  Lys Gly Gly Arg His  Leu Ile Phe Cys His  Ser Lys Lys 
    1385                 1390                 1395             


Lys Cys  Asp Glu Leu Ala Ala  Lys Leu Val Ala Leu  Gly Ile Asn 
    1400                 1405                 1410             


Ala Val  Ala Tyr Tyr Arg Gly  Leu Asp Val Ser Val  Ile Pro Thr 
    1415                 1420                 1425             


Ser Gly  Asp Val Val Val Val  Ala Thr Asp Ala Leu  Met Thr Gly 
    1430                 1435                 1440             


Tyr Thr  Gly Asp Phe Asp Ser  Val Ile Asp Cys Asn  Thr Cys Val 
    1445                 1450                 1455             


Thr Gln  Thr Val Asp Leu Ser  Leu Asp Pro Thr Phe  Thr Ile Glu 
    1460                 1465                 1470             


Thr Thr  Thr Leu Pro Gln Asp  Ala Val Ser Arg Thr  Gln Arg Arg 
    1475                 1480                 1485             


Gly Arg  Thr Gly Arg Gly Lys  Pro Gly Ile Tyr Arg  Phe Val Ala 
    1490                 1495                 1500             


Leu Gly  Glu Arg Pro Ser Gly  Met Phe Asp Ser Ser  Val Leu Cys 
    1505                 1510                 1515             


Glu Cys  Tyr Asp Ala Gly Cys  Ala Trp Tyr Glu Leu  Thr Pro Ala 
    1520                 1525                 1530             


Glu Thr  Thr Val Arg Leu Arg  Ala Tyr Met Asn Thr  Pro Gly Leu 
    1535                 1540                 1545             


Pro Val  Cys Gln Asp His Leu  Glu Phe Trp Glu Gly  Val Phe Thr 
    1550                 1555                 1560             


Gly Leu  Thr His Ile Asp Ala  His Phe Leu Ser Gln  Thr Lys Gln 
    1565                 1570                 1575             


Ser Gly  Glu Asn Phe Pro Tyr  Leu Val Ala Tyr Gln  Ala Thr Val 
    1580                 1585                 1590             


Cys Ala  Arg Ala Gln Ala Pro  Pro Pro Ser Trp Asp  Gln Met Trp 
    1595                 1600                 1605             


Lys Cys  Leu Thr Arg Leu Lys  Pro Thr Leu His Gly  Pro Thr Pro 
    1610                 1615                 1620             


Leu Leu  Tyr Arg Leu Gly Ala  Val Gln Asn Glu Val  Thr Leu Thr 
    1625                 1630                 1635             


His Pro  Ile Thr Lys Tyr Ile  Met Thr Cys Met Ser  Ala Asp Leu 
    1640                 1645                 1650             


Glu Val  Val Thr Ser Thr Trp  Val Leu Val Gly Gly  Val Leu Ala 
    1655                 1660                 1665             


Ala Leu  Ala Ser Tyr Cys Leu  Ser Thr Gly Cys Val  Val Ile Val 
    1670                 1675                 1680             


Gly Arg  Ile Val Leu Ser Gly  Lys Pro Ala Ile Ile  Pro Asp Arg 
    1685                 1690                 1695             


Glu Val  Leu Tyr Arg Glu Phe  Asp Glu Met Glu Glu  Cys Ser Gln 
    1700                 1705                 1710             


His Leu  Pro Tyr Ile Glu Gln  Gly Met Met Leu Ala  Glu Gln Phe 
    1715                 1720                 1725             


Lys Gln  Lys Ala Leu Gly Leu  Leu Gln Thr Ala Ser  Arg Gln Ala 
    1730                 1735                 1740             


Glu Val  Val Ala Pro Ala Val  Gln Thr Asn Trp Gln  Lys Leu Glu 
    1745                 1750                 1755             


Ala Phe  Trp Ala Lys His Met  Trp Asn Phe Ile Ser  Gly Ile Gln 
    1760                 1765                 1770             


Tyr Leu  Ala Gly Leu Ser Thr  Leu Pro Gly Asn Pro  Ala Ile Ala 
    1775                 1780                 1785             


Ser Leu  Met Ala Phe Thr Ala  Ala Val Thr Ser Pro  Leu Thr Thr 
    1790                 1795                 1800             


Ser Gln  Thr Leu Leu Phe Asn  Ile Leu Gly Gly Trp  Val Ala Ala 
    1805                 1810                 1815             


Gln Leu  Ala Ala Pro Gly Ala  Ala Thr Ala Phe Val  Gly Ala Gly 
    1820                 1825                 1830             


Leu Ala  Gly Ala Ala Ile Gly  Ser Val Gly Leu Gly  Lys Val Leu 
    1835                 1840                 1845             


Val Asp  Ile Leu Ala Gly Tyr  Gly Ala Gly Val Ala  Gly Ala Leu 
    1850                 1855                 1860             


Val Ala  Phe Lys Ile Met Ser  Gly Glu Val Pro Ser  Thr Glu Asp 
    1865                 1870                 1875             


Leu Val  Asn Leu Leu Pro Ala  Ile Leu Ser Pro Gly  Ala Leu Val 
    1880                 1885                 1890             


Val Gly  Val Val Cys Ala Ala  Ile Leu Arg Arg His  Val Gly Pro 
    1895                 1900                 1905             


Gly Glu  Gly Ala Val Gln Trp  Met Asn Arg Leu Ile  Ala Phe Ala 
    1910                 1915                 1920             


Ser Arg  Gly Asn His Val Ser  Pro Thr His Tyr Val  Pro Glu Ser 
    1925                 1930                 1935             


Asp Ala  Ala Ala Arg Val Thr  Thr Ile Leu Ser Ser  Leu Thr Val 
    1940                 1945                 1950             


Thr Gln  Leu Leu Arg Arg Leu  His Gln Trp Ile Ser  Ser Glu Cys 
    1955                 1960                 1965             


Thr Thr  Pro Cys Ser Gly Ser  Trp Leu Arg Asp Ile  Trp Asp Trp 
    1970                 1975                 1980             


Ile Cys  Glu Val Leu Ser Asp  Phe Lys Thr Trp Leu  Lys Ala Lys 
    1985                 1990                 1995             


Leu Met  Pro Gln Leu Pro Gly  Ile Pro Phe Val Ser  Cys Gln Arg 
    2000                 2005                 2010             


Gly Tyr  Lys Gly Val Trp Arg  Gly Asp Gly Ile Met  His Thr Arg 
    2015                 2020                 2025             


Cys His  Cys Gly Ala Glu Ile  Thr Gly His Val Lys  Asn Gly Thr 
    2030                 2035                 2040             


Met Arg  Ile Val Gly Pro Lys  Thr Cys Arg Asn Met  Trp Ser Gly 
    2045                 2050                 2055             


Thr Phe  Pro Ile Asn Ala Tyr  Thr Thr Gly Pro Cys  Thr Pro Leu 
    2060                 2065                 2070             


Pro Ala  Pro Asn Tyr Thr Phe  Ala Leu Trp Arg Val  Ser Ala Glu 
    2075                 2080                 2085             


Glu Tyr  Val Glu Ile Arg Gln  Val Gly Asp Phe His  Tyr Val Thr 
    2090                 2095                 2100             


Gly Met  Thr Thr Asp Asn Leu  Lys Cys Pro Cys Gln  Val Pro Ser 
    2105                 2110                 2115             


Pro Glu  Phe Phe Thr Glu Leu  Asp Gly Val Arg Leu  His Arg Phe 
    2120                 2125                 2130             


Ala Pro  Pro Cys Lys Pro Leu  Leu Arg Glu Glu Val  Ser Phe Arg 
    2135                 2140                 2145             


Val Gly  Leu His Glu Tyr Pro  Val Gly Ser Gln Leu  Pro Cys Glu 
    2150                 2155                 2160             


Pro Glu  Pro Asp Val Ala Val  Leu Thr Ser Met Leu  Thr Asp Pro 
    2165                 2170                 2175             


Ser His  Ile Thr Ala Glu Ala  Ala Gly Arg Arg Leu  Ala Arg Gly 
    2180                 2185                 2190             


Ser Pro  Pro Ser Met Ala Ser  Ser Ser Ala Ser Gln  Leu Ser Ala 
    2195                 2200                 2205             


Pro Ser  Leu Arg Ala Thr Cys  Thr Thr Asn His Asp  Ser Pro Asp 
    2210                 2215                 2220             


Ala Glu  Leu Ile Glu Ala Asn  Leu Leu Trp Arg Gln  Glu Met Gly 
    2225                 2230                 2235             


Gly Asn  Ile Thr Arg Val Glu  Ser Glu Asn Lys Val  Val Ile Leu 
    2240                 2245                 2250             


Asp Ser  Phe Asp Pro Leu Val  Ala Glu Glu Asp Glu  Arg Glu Val 
    2255                 2260                 2265             


Ser Val  Pro Ala Glu Ile Leu  Arg Lys Ser Arg Lys  Phe Thr Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ile Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Pro  Trp Lys Lys Pro Asp  Tyr Glu Pro Pro Val  Val His Gly 
    2300                 2305                 2310             


Cys Pro  Leu Pro Pro Pro Gln  Ser Pro Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Lys Lys  Arg Thr Val Ile Leu  Thr Glu Ser Thr Leu  Pro Thr Ala 
    2330                 2335                 2340             


Leu Ala  Glu Leu Ala Thr Lys  Ser Phe Gly Ser Ser  Ser Thr Ser 
    2345                 2350                 2355             


Gly Ile  Thr Gly Asp Asp Thr  Thr Thr Ser Pro Glu  Pro Ala Ser 
    2360                 2365                 2370             


Ser Ser  Cys Pro Pro Asp Ser  Asp Ala Glu Ser Tyr  Ser Ser Met 
    2375                 2380                 2385             


Pro Pro  Leu Glu Gly Glu Pro  Gly Asp Pro Asp Leu  Ser Asp Gly 
    2390                 2395                 2400             


Ser Trp  Ser Thr Val Ser Ser  Glu Ala Asp Lys Glu  Asp Val Val 
    2405                 2410                 2415             


Cys Cys  Ser Met Ser Tyr Thr  Trp Thr Gly Ala Leu  Val Thr Pro 
    2420                 2425                 2430             


Cys Ala  Ala Glu Glu Gln Lys  Leu Pro Ile Asn Ala  Leu Ser Asn 
    2435                 2440                 2445             


Ser Leu  Leu Arg His His Asn  Leu Val Tyr Ser Thr  Thr Ser Arg 
    2450                 2455                 2460             


Ser Ala  Cys Gln Arg Gln Lys  Lys Val Thr Phe Asp  Arg Leu Gln 
    2465                 2470                 2475             


Val Leu  Asp Ser His Tyr Gln  Asp Val Leu Lys Glu  Val Lys Ala 
    2480                 2485                 2490             


Ala Ala  Ser Lys Val Lys Ala  Asn Leu Leu Ser Val  Glu Glu Ala 
    2495                 2500                 2505             


Cys Ser  Leu Thr Pro Pro His  Ser Ala Lys Ser Lys  Phe Gly Tyr 
    2510                 2515                 2520             


Gly Ala  Lys Asp Val Arg Cys  His Ala Arg Lys Ala  Val Asn His 
    2525                 2530                 2535             


Ile Asn  Ser Val Trp Lys Asp  Leu Leu Glu Asp Ser  Val Thr Pro 
    2540                 2545                 2550             


Ile Asp  Thr Thr Ile Met Ala  Lys Asn Glu Val Phe  Cys Val Gln 
    2555                 2560                 2565             


Pro Glu  Lys Gly Gly Arg Lys  Pro Ala Arg Leu Ile  Val Phe Pro 
    2570                 2575                 2580             


Asp Leu  Gly Val Arg Val Cys  Glu Lys Met Ala Leu  Tyr Asp Val 
    2585                 2590                 2595             


Val Ser  Lys Leu Pro Leu Ala  Val Met Gly Ser Ser  Tyr Gly Phe 
    2600                 2605                 2610             


Gln Tyr  Ser Pro Gly Gln Arg  Val Glu Phe Leu Val  Gln Ala Trp 
    2615                 2620                 2625             


Lys Ser  Lys Lys Thr Pro Met  Gly Phe Ser Tyr Asp  Thr Arg Cys 
    2630                 2635                 2640             


Phe Asp  Ser Thr Val Thr Glu  Asn Asp Ile Arg Thr  Glu Glu Ala 
    2645                 2650                 2655             


Ile Tyr  Gln Cys Cys Asp Leu  Asp Pro Gln Ala Arg  Val Ala Ile 
    2660                 2665                 2670             


Lys Ser  Leu Thr Glu Arg Leu  Tyr Val Gly Gly Pro  Leu Thr Asn 
    2675                 2680                 2685             


Ser Arg  Gly Glu Asn Cys Gly  Tyr Arg Arg Cys Arg  Ala Ser Gly 
    2690                 2695                 2700             


Val Leu  Thr Thr Ser Cys Gly  Asn Thr Leu Thr Cys  Tyr Ile Lys 
    2705                 2710                 2715             


Ala Arg  Ala Ala Cys Arg Ala  Ala Gly Leu Gln Asp  Cys Thr Met 
    2720                 2725                 2730             


Leu Val  Cys Gly Asp Asp Leu  Val Val Ile Cys Glu  Ser Ala Gly 
    2735                 2740                 2745             


Val Gln  Glu Asp Ala Ala Ser  Leu Arg Ala Phe Thr  Glu Ala Met 
    2750                 2755                 2760             


Thr Arg  Tyr Ser Ala Pro Pro  Gly Asp Pro Pro Gln  Pro Glu Tyr 
    2765                 2770                 2775             


Asp Leu  Glu Leu Ile Thr Ser  Cys Ser Ser Asn Val  Ser Val Ala 
    2780                 2785                 2790             


His Asp  Gly Ala Gly Lys Arg  Val Tyr Tyr Leu Thr  Arg Asp Pro 
    2795                 2800                 2805             


Thr Thr  Pro Leu Ala Arg Ala  Ala Trp Glu Thr Ala  Arg His Thr 
    2810                 2815                 2820             


Pro Val  Asn Ser Trp Leu Gly  Asn Ile Ile Met Phe  Ala Pro Thr 
    2825                 2830                 2835             


Leu Trp  Ala Arg Met Ile Leu  Met Thr His Phe Phe  Ser Val Leu 
    2840                 2845                 2850             


Ile Ala  Arg Asp Gln Leu Glu  Gln Ala Leu Asp Cys  Glu Ile Tyr 
    2855                 2860                 2865             


Gly Ala  Cys Tyr Ser Ile Glu  Pro Leu Asp Leu Pro  Pro Ile Ile 
    2870                 2875                 2880             


Gln Arg  Leu His Gly Leu Ser  Ala Phe Ser Leu His  Ser Tyr Ser 
    2885                 2890                 2895             


Pro Gly  Glu Ile Asn Arg Val  Ala Ala Cys Leu Arg  Lys Leu Gly 
    2900                 2905                 2910             


Val Pro  Pro Leu Arg Ala Trp  Arg His Arg Ala Arg  Asn Val Arg 
    2915                 2920                 2925             


Ala Arg  Leu Leu Ser Arg Gly  Gly Arg Ala Ala Ile  Cys Gly Lys 
    2930                 2935                 2940             


Tyr Leu  Phe Asn Trp Ala Val  Arg Thr Lys Leu Lys  Leu Thr Pro 
    2945                 2950                 2955             


Ile Ala  Ala Ala Gly Arg Leu  Asp Leu Ser Gly Trp  Phe Thr Ala 
    2960                 2965                 2970             


Gly Tyr  Ser Gly Gly Gly Ile  Phe His Ser Val Ser  His Ala Arg 
    2975                 2980                 2985             


Pro Arg  Trp Phe Trp Phe Cys  Leu Leu Leu Leu Ala  Ala Gly Val 
    2990                 2995                 3000             


Gly Ile  Tyr Leu Leu Pro Asn  Arg 
    3005                 3010     


<210>  152
<211>  3011
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  plasmid

<400>  152

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Gly Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Thr Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Phe Glu Ala Ala Asp Ala Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Val Thr Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Thr Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Ser Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Ala Leu Leu Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Met Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr Tyr Val Thr Gly Gly Ser Ala Ala Arg Thr Thr Ala Gly Leu Ala 
385                 390                 395                 400 


Ser Leu Phe Ser Pro Gly Ala Lys Gln Asn Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Asn Thr Gly Trp Ile Ala Gly Leu Phe Tyr His His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Ser Glu Arg Leu Ala Ser Cys Arg Pro Leu Thr Asp 
    450                 455                 460                 


Phe Ala Gln Gly Trp Gly Pro Ile Ser His Ala Asp Gly Ser Gly Pro 
465                 470                 475                 480 


Asp Gln Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Lys Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly Ala Pro Thr Tyr Ser 
        515                 520                 525             


Trp Gly Ala Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu Arg Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Ile Asn Tyr 
    610                 615                 620                 


Thr Val Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Glu Ala Ala Cys Asn Trp Thr Arg Gly Asp Arg Cys Asn Leu Asp Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Ile Ala Ser Trp Ala Ile Lys Trp Glu Tyr Val Val 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Val Glu Ala Ala Leu Glu Asn Leu Val 
            740                 745                 750         


Val Leu Asn Ala Ala Ser Leu Ala Gly Thr His Gly Leu Val Ser Phe 
        755                 760                 765             


Leu Val Phe Phe Cys Phe Ala Trp Tyr Leu Lys Gly Lys Trp Val Pro 
    770                 775                 780                 


Gly Ala Val Tyr Ala Leu Tyr Gly Met Trp Pro Leu Leu Leu Leu Leu 
785                 790                 795                 800 


Leu Ala Leu Pro Gln Arg Ala Tyr Ala Leu Asp Thr Glu Val Ala Ala 
                805                 810                 815     


Ser Cys Gly Gly Val Val Leu Val Gly Leu Met Ala Leu Thr Leu Ser 
            820                 825                 830         


Pro Tyr Tyr Lys Arg Tyr Ile Ser Trp Cys Leu Trp Trp Leu Gln Tyr 
        835                 840                 845             


Phe Leu Thr Arg Ile Glu Ala Gln Leu His Val Trp Ile Pro Pro Leu 
    850                 855                 860                 


Asn Val Arg Gly Gly Arg Asp Ala Val Ile Leu Leu Met Cys Val Val 
865                 870                 875                 880 


His Pro Ala Leu Val Phe Asp Ile Thr Lys Leu Leu Leu Ala Ala Phe 
                885                 890                 895     


Gly Pro Leu Trp Ile Leu Gln Ala Ser Leu Leu Lys Val Pro Tyr Phe 
            900                 905                 910         


Val Arg Val Gln Gly Leu Leu Arg Ile Cys Ala Leu Ala Arg Lys Met 
        915                 920                 925             


Ala Gly Gly His Tyr Val Gln Met Ala Ile Ile Lys Leu Gly Ala Leu 
    930                 935                 940                 


Thr Gly Thr Tyr Val Tyr Asn His Leu Thr Pro Leu Arg Asp Trp Ala 
945                 950                 955                 960 


His Asn Gly Leu Arg Asp Leu Ala Val Ala Val Glu Pro Val Val Phe 
                965                 970                 975     


Ser Arg Met Glu Thr Lys Leu Ile Thr Trp Gly Ala Asp Thr Ala Ala 
            980                 985                 990         


Cys Gly Asp Ile Ile Asn Gly Leu  Pro Val Ser Ala Arg  Arg Gly Arg 
        995                 1000                 1005             


Glu Ile  Leu Leu Gly Pro Ala  Asp Gly Met Val Ser  Lys Gly Trp 
    1010                 1015                 1020             


Arg Leu  Leu Ala Pro Ile Thr  Ala Tyr Ala Gln Gln  Thr Arg Gly 
    1025                 1030                 1035             


Leu Leu  Gly Cys Ile Ile Thr  Ser Leu Thr Gly Arg  Asp Lys Asn 
    1040                 1045                 1050             


Gln Val  Glu Gly Glu Ile Gln  Ile Val Ser Thr Ala  Ala Gln Thr 
    1055                 1060                 1065             


Phe Leu  Ala Thr Cys Ile Asn  Gly Val Cys Trp Thr  Val Tyr His 
    1070                 1075                 1080             


Gly Ala  Gly Thr Arg Thr Ile  Ala Ser Pro Lys Gly  Pro Val Ile 
    1085                 1090                 1095             


Gln Met  Tyr Thr Asn Val Asp  Lys Asp Leu Val Gly  Trp Pro Ala 
    1100                 1105                 1110             


Pro Gln  Gly Ala Arg Ser Leu  Thr Pro Cys Thr Cys  Gly Ser Ser 
    1115                 1120                 1125             


Asp Leu  Tyr Leu Val Thr Arg  His Ala Asp Val Ile  Pro Val Arg 
    1130                 1135                 1140             


Arg Arg  Gly Asp Ser Arg Gly  Ser Leu Leu Ser Pro  Arg Pro Ile 
    1145                 1150                 1155             


Ser Tyr  Leu Lys Gly Ser Ser  Gly Gly Pro Leu Leu  Cys Pro Ala 
    1160                 1165                 1170             


Gly His  Ala Val Gly Leu Phe  Arg Ala Ala Val Cys  Thr Arg Gly 
    1175                 1180                 1185             


Val Ala  Lys Ala Val Asp Phe  Ile Pro Val Glu Asn  Leu Glu Thr 
    1190                 1195                 1200             


Thr Met  Arg Ser Pro Val Phe  Thr Asp Asn Ser Ser  Pro Pro Ala 
    1205                 1210                 1215             


Val Pro  Gln Ser Phe Gln Val  Gly His Leu His Ala  Pro Thr Gly 
    1220                 1225                 1230             


Ser Gly  Lys Ser Thr Lys Val  Pro Ala Ala Tyr Ala  Ala Gln Gly 
    1235                 1240                 1245             


Tyr Lys  Val Leu Val Leu Asn  Pro Ser Val Ala Ala  Thr Leu Gly 
    1250                 1255                 1260             


Phe Gly  Ala Tyr Met Ser Lys  Ala His Gly Val Asp  Pro Asn Ile 
    1265                 1270                 1275             


Arg Thr  Gly Val Arg Thr Ile  Thr Thr Gly Ser Pro  Ile Thr Tyr 
    1280                 1285                 1290             


Ser Thr  Tyr Gly Lys Phe Leu  Ala Asp Gly Gly Cys  Ser Gly Gly 
    1295                 1300                 1305             


Ala Tyr  Asp Ile Ile Ile Cys  Asp Glu Cys His Ser  Thr Asp Ala 
    1310                 1315                 1320             


Thr Ser  Ile Leu Gly Ile Gly  Thr Val Leu Asp Gln  Ala Glu Thr 
    1325                 1330                 1335             


Ala Gly  Ala Arg Leu Val Val  Leu Ala Thr Ala Thr  Pro Pro Gly 
    1340                 1345                 1350             


Ser Ile  Thr Val Pro His Pro  Asn Ile Glu Glu Val  Ala Leu Ser 
    1355                 1360                 1365             


Thr Thr  Gly Glu Ile Pro Phe  Tyr Gly Lys Ala Ile  Pro Leu Glu 
    1370                 1375                 1380             


Ala Ile  Lys Gly Gly Arg His  Leu Ile Phe Cys His  Ser Lys Lys 
    1385                 1390                 1395             


Lys Cys  Asp Glu Leu Ala Ala  Lys Leu Val Ala Leu  Gly Ile Asn 
    1400                 1405                 1410             


Ala Val  Ala Tyr Tyr Arg Gly  Leu Asp Val Ser Val  Ile Pro Thr 
    1415                 1420                 1425             


Ser Gly  Asp Val Val Val Val  Ala Thr Asp Ala Leu  Met Thr Gly 
    1430                 1435                 1440             


Tyr Thr  Gly Asp Phe Asp Ser  Val Ile Asp Cys Asn  Thr Cys Val 
    1445                 1450                 1455             


Thr Gln  Thr Val Asp Leu Ser  Leu Asp Pro Thr Phe  Thr Ile Glu 
    1460                 1465                 1470             


Thr Thr  Thr Leu Pro Gln Asp  Ala Val Ser Arg Thr  Gln Arg Arg 
    1475                 1480                 1485             


Gly Arg  Thr Gly Arg Gly Lys  Pro Gly Ile Tyr Arg  Phe Val Ala 
    1490                 1495                 1500             


Leu Gly  Glu Arg Pro Ser Gly  Met Phe Asp Ser Ser  Val Leu Cys 
    1505                 1510                 1515             


Glu Cys  Tyr Asp Ala Gly Cys  Ala Trp Tyr Glu Leu  Thr Pro Ala 
    1520                 1525                 1530             


Glu Thr  Thr Val Arg Leu Arg  Ala Tyr Met Asn Thr  Pro Gly Leu 
    1535                 1540                 1545             


Pro Val  Cys Gln Asp His Leu  Glu Phe Trp Glu Gly  Val Phe Thr 
    1550                 1555                 1560             


Gly Leu  Thr His Ile Asp Ala  His Phe Leu Ser Gln  Thr Lys Gln 
    1565                 1570                 1575             


Ser Gly  Glu Asn Phe Pro Tyr  Leu Val Ala Tyr Gln  Ala Thr Val 
    1580                 1585                 1590             


Cys Ala  Arg Ala Gln Ala Pro  Pro Pro Ser Trp Asp  Gln Met Trp 
    1595                 1600                 1605             


Lys Cys  Leu Thr Arg Leu Lys  Pro Thr Leu His Gly  Pro Thr Pro 
    1610                 1615                 1620             


Leu Leu  Tyr Arg Leu Gly Ala  Val Gln Asn Glu Val  Thr Leu Thr 
    1625                 1630                 1635             


His Pro  Ile Thr Lys Tyr Ile  Met Thr Cys Met Ser  Ala Asp Leu 
    1640                 1645                 1650             


Glu Val  Val Thr Ser Thr Trp  Val Leu Val Gly Gly  Val Leu Ala 
    1655                 1660                 1665             


Ala Leu  Ala Ser Tyr Cys Leu  Ser Thr Gly Cys Val  Val Ile Val 
    1670                 1675                 1680             


Gly Arg  Ile Val Leu Ser Gly  Lys Pro Ala Ile Ile  Pro Asp Arg 
    1685                 1690                 1695             


Glu Val  Leu Tyr Arg Glu Phe  Asp Glu Met Glu Glu  Cys Ser Gln 
    1700                 1705                 1710             


His Leu  Pro Tyr Ile Glu Gln  Gly Met Met Leu Ala  Glu Gln Phe 
    1715                 1720                 1725             


Lys Gln  Lys Ala Leu Gly Leu  Leu Gln Thr Ala Ser  Arg Gln Ala 
    1730                 1735                 1740             


Glu Val  Val Ala Pro Ala Val  Gln Thr Asn Trp Gln  Lys Leu Glu 
    1745                 1750                 1755             


Ala Phe  Trp Ala Lys His Met  Trp Asn Phe Ile Ser  Gly Ile His 
    1760                 1765                 1770             


Tyr Leu  Ala Gly Leu Ser Thr  Leu Pro Gly Asn Pro  Ala Ile Ala 
    1775                 1780                 1785             


Ser Leu  Met Ala Phe Thr Ala  Ala Val Thr Ser Pro  Leu Thr Thr 
    1790                 1795                 1800             


Ser Gln  Thr Leu Leu Phe Asn  Ile Leu Gly Gly Trp  Val Ala Ala 
    1805                 1810                 1815             


Gln Leu  Ala Ala Pro Gly Ala  Ala Thr Ala Phe Val  Gly Ala Gly 
    1820                 1825                 1830             


Leu Ala  Gly Ala Ala Ile Gly  Ser Val Gly Leu Gly  Lys Val Leu 
    1835                 1840                 1845             


Val Asp  Ile Leu Ala Gly Tyr  Gly Ala Gly Val Ala  Gly Ala Leu 
    1850                 1855                 1860             


Val Ala  Phe Lys Ile Met Ser  Gly Glu Val Pro Ser  Thr Glu Asp 
    1865                 1870                 1875             


Leu Val  Asn Leu Leu Pro Ala  Ile Leu Ser Pro Gly  Ala Leu Val 
    1880                 1885                 1890             


Val Gly  Val Val Cys Ala Ala  Ile Leu Arg Arg His  Val Gly Pro 
    1895                 1900                 1905             


Gly Glu  Gly Ala Val Gln Trp  Met Asn Arg Leu Ile  Ala Phe Ala 
    1910                 1915                 1920             


Ser Arg  Gly Asn His Val Ser  Pro Thr His Tyr Val  Pro Glu Ser 
    1925                 1930                 1935             


Asp Ala  Ala Ala Arg Val Thr  Thr Ile Leu Ser Ser  Leu Thr Val 
    1940                 1945                 1950             


Thr Gln  Leu Leu Arg Arg Leu  His Gln Trp Ile Ser  Ser Glu Cys 
    1955                 1960                 1965             


Thr Thr  Pro Cys Ser Gly Ser  Trp Leu Arg Asp Ile  Trp Asp Trp 
    1970                 1975                 1980             


Ile Cys  Glu Val Leu Ser Asp  Phe Lys Thr Trp Leu  Lys Ala Lys 
    1985                 1990                 1995             


Leu Met  Pro Gln Leu Pro Gly  Ile Pro Phe Val Ser  Cys Gln Arg 
    2000                 2005                 2010             


Gly Tyr  Lys Gly Val Trp Arg  Gly Asp Gly Ile Met  His Thr Arg 
    2015                 2020                 2025             


Cys His  Cys Gly Ala Glu Ile  Thr Gly His Val Lys  Asn Gly Thr 
    2030                 2035                 2040             


Met Arg  Ile Val Gly Pro Lys  Thr Cys Arg Asn Met  Trp Ser Gly 
    2045                 2050                 2055             


Thr Phe  Pro Ile Asn Ala Tyr  Thr Thr Gly Pro Cys  Thr Pro Leu 
    2060                 2065                 2070             


Pro Ala  Pro Asn Tyr Thr Phe  Ala Leu Trp Arg Val  Ser Ala Glu 
    2075                 2080                 2085             


Glu Tyr  Val Glu Ile Arg Gln  Val Gly Asp Phe His  Tyr Val Thr 
    2090                 2095                 2100             


Gly Met  Thr Thr Asp Asn Leu  Lys Cys Pro Cys Gln  Val Pro Ser 
    2105                 2110                 2115             


Pro Glu  Phe Phe Thr Glu Leu  Asp Gly Val Arg Leu  His Arg Phe 
    2120                 2125                 2130             


Ala Pro  Pro Cys Lys Pro Leu  Leu Arg Glu Glu Val  Ser Phe Arg 
    2135                 2140                 2145             


Val Gly  Leu His Glu Tyr Pro  Val Gly Ser Gln Leu  Pro Cys Glu 
    2150                 2155                 2160             


Pro Glu  Pro Asp Val Ala Val  Leu Thr Ser Met Leu  Thr Asp Pro 
    2165                 2170                 2175             


Ser His  Ile Thr Ala Glu Ala  Ala Gly Arg Arg Leu  Ala Arg Gly 
    2180                 2185                 2190             


Ser Pro  Pro Ser Met Ala Ser  Ser Ser Ala Ser Gln  Leu Ser Ala 
    2195                 2200                 2205             


Pro Ser  Leu Arg Ala Thr Cys  Thr Thr Asn His Asp  Ser Pro Asp 
    2210                 2215                 2220             


Ala Glu  Leu Ile Glu Ala Asn  Leu Leu Trp Arg Gln  Glu Met Gly 
    2225                 2230                 2235             


Gly Asn  Ile Thr Arg Val Glu  Ser Glu Asn Lys Val  Val Ile Leu 
    2240                 2245                 2250             


Asp Ser  Phe Asp Pro Leu Val  Ala Glu Glu Asp Glu  Arg Glu Val 
    2255                 2260                 2265             


Ser Val  Pro Ala Glu Ile Leu  Arg Lys Ser Arg Lys  Phe Thr Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ile Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Pro  Trp Lys Lys Pro Asp  Tyr Glu Pro Pro Val  Val His Gly 
    2300                 2305                 2310             


Cys Pro  Leu Pro Pro Pro Gln  Ser Pro Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Lys Lys  Arg Thr Val Ile Leu  Thr Glu Ser Thr Leu  Pro Thr Ala 
    2330                 2335                 2340             


Leu Ala  Glu Leu Ala Thr Lys  Ser Phe Gly Ser Ser  Ser Thr Ser 
    2345                 2350                 2355             


Gly Ile  Thr Gly Asp Asp Thr  Thr Thr Ser Pro Glu  Pro Ala Ser 
    2360                 2365                 2370             


Ser Ser  Cys Pro Pro Asp Ser  Asp Ala Glu Ser Tyr  Ser Ser Met 
    2375                 2380                 2385             


Pro Pro  Leu Glu Gly Glu Pro  Gly Asp Pro Asp Leu  Ser Asp Gly 
    2390                 2395                 2400             


Ser Trp  Ser Thr Val Ser Ser  Glu Ala Asp Lys Glu  Asp Val Val 
    2405                 2410                 2415             


Cys Cys  Ser Met Ser Tyr Thr  Trp Thr Gly Ala Leu  Val Thr Pro 
    2420                 2425                 2430             


Cys Ala  Ala Glu Glu Gln Lys  Leu Pro Ile Asn Ala  Leu Ser Asn 
    2435                 2440                 2445             


Ser Leu  Leu Arg His His Asn  Leu Val Tyr Ser Thr  Thr Ser Arg 
    2450                 2455                 2460             


Ser Ala  Cys Gln Arg Gln Lys  Lys Val Thr Phe Asp  Arg Leu Gln 
    2465                 2470                 2475             


Val Leu  Asp Ser His Tyr Gln  Asp Val Leu Lys Glu  Val Lys Ala 
    2480                 2485                 2490             


Ala Ala  Ser Lys Val Lys Ala  Asn Leu Leu Ser Val  Glu Glu Ala 
    2495                 2500                 2505             


Cys Ser  Leu Thr Pro Pro His  Ser Ala Lys Ser Lys  Phe Gly Tyr 
    2510                 2515                 2520             


Gly Ala  Lys Asp Val Arg Cys  His Ala Arg Lys Ala  Val Asn His 
    2525                 2530                 2535             


Ile Asn  Ser Val Trp Lys Asp  Leu Leu Glu Asp Ser  Val Thr Pro 
    2540                 2545                 2550             


Ile Asp  Thr Thr Ile Met Ala  Lys Asn Glu Val Phe  Cys Val Gln 
    2555                 2560                 2565             


Pro Glu  Lys Gly Gly Arg Lys  Pro Ala Arg Leu Ile  Val Phe Pro 
    2570                 2575                 2580             


Asp Leu  Gly Val Arg Val Cys  Glu Lys Met Ala Leu  Tyr Asp Val 
    2585                 2590                 2595             


Val Ser  Lys Leu Pro Leu Ala  Val Met Gly Ser Ser  Tyr Gly Phe 
    2600                 2605                 2610             


Gln Tyr  Ser Pro Gly Gln Arg  Val Glu Phe Leu Val  Gln Ala Trp 
    2615                 2620                 2625             


Lys Ser  Lys Lys Thr Pro Met  Gly Phe Ser Tyr Asp  Thr Arg Cys 
    2630                 2635                 2640             


Phe Asp  Ser Thr Val Thr Glu  Asn Asp Ile Arg Thr  Glu Glu Ala 
    2645                 2650                 2655             


Ile Tyr  Gln Cys Cys Asp Leu  Asp Pro Gln Ala Arg  Val Ala Ile 
    2660                 2665                 2670             


Lys Ser  Leu Thr Glu Arg Leu  Tyr Val Gly Gly Pro  Leu Thr Asn 
    2675                 2680                 2685             


Ser Arg  Gly Glu Asn Cys Gly  Tyr Arg Arg Cys Arg  Ala Ser Gly 
    2690                 2695                 2700             


Val Leu  Thr Thr Ser Cys Gly  Asn Thr Leu Thr Cys  Tyr Ile Lys 
    2705                 2710                 2715             


Ala Arg  Ala Ala Cys Arg Ala  Ala Gly Leu Gln Asp  Cys Thr Met 
    2720                 2725                 2730             


Leu Val  Cys Gly Asp Asp Leu  Val Val Ile Cys Glu  Ser Ala Gly 
    2735                 2740                 2745             


Val Gln  Glu Asp Ala Ala Ser  Leu Arg Ala Phe Thr  Glu Ala Met 
    2750                 2755                 2760             


Thr Arg  Tyr Ser Ala Pro Pro  Gly Asp Pro Pro Gln  Pro Glu Tyr 
    2765                 2770                 2775             


Asp Leu  Glu Leu Ile Thr Ser  Cys Ser Ser Asn Val  Ser Val Ala 
    2780                 2785                 2790             


His Asp  Gly Ala Gly Lys Arg  Val Tyr Tyr Leu Thr  Arg Asp Pro 
    2795                 2800                 2805             


Thr Thr  Pro Leu Ala Arg Ala  Ala Trp Glu Thr Ala  Arg His Thr 
    2810                 2815                 2820             


Pro Val  Asn Ser Trp Leu Gly  Asn Ile Ile Met Phe  Ala Pro Thr 
    2825                 2830                 2835             


Leu Trp  Ala Arg Met Ile Leu  Met Thr His Phe Phe  Ser Val Leu 
    2840                 2845                 2850             


Ile Ala  Arg Asp Gln Leu Glu  Gln Ala Leu Asp Cys  Glu Ile Tyr 
    2855                 2860                 2865             


Gly Ala  Cys Tyr Ser Ile Glu  Pro Leu Asp Leu Pro  Pro Ile Ile 
    2870                 2875                 2880             


Gln Arg  Leu His Gly Leu Ser  Ala Phe Ser Leu His  Ser Tyr Ser 
    2885                 2890                 2895             


Pro Gly  Glu Ile Asn Arg Val  Ala Ala Cys Leu Arg  Lys Leu Gly 
    2900                 2905                 2910             


Val Pro  Pro Leu Arg Ala Trp  Arg His Arg Ala Arg  Asn Val Arg 
    2915                 2920                 2925             


Ala Arg  Leu Leu Ser Arg Gly  Gly Arg Ala Ala Ile  Cys Gly Lys 
    2930                 2935                 2940             


Tyr Leu  Phe Asn Trp Ala Val  Arg Thr Lys Leu Lys  Leu Thr Pro 
    2945                 2950                 2955             


Ile Ala  Ala Ala Gly Arg Leu  Asp Leu Ser Gly Trp  Phe Thr Ala 
    2960                 2965                 2970             


Gly Tyr  Ser Gly Gly Gly Ile  Phe His Ser Val Ser  His Ala Arg 
    2975                 2980                 2985             


Pro Arg  Trp Phe Trp Phe Cys  Leu Leu Leu Leu Ala  Ala Gly Val 
    2990                 2995                 3000             


Gly Ile  Tyr Leu Leu Pro Asn  Arg 
    3005                 3010     


<210>  153
<211>  3011
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  plasmid

<400>  153

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Gly Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Thr Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Phe Glu Ala Ala Asp Ala Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Val Thr Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Thr Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Ser Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Ala Leu Leu Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Met Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr Tyr Val Thr Gly Gly Ser Ala Ala Arg Thr Thr Ala Gly Leu Ala 
385                 390                 395                 400 


Ser Leu Phe Ser Pro Gly Ala Lys Gln Asn Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Asn Thr Gly Trp Ile Ala Gly Leu Phe Tyr His His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Ser Glu Arg Leu Ala Ser Cys Arg Pro Leu Thr Asp 
    450                 455                 460                 


Phe Ala Gln Gly Trp Gly Pro Ile Ser His Ala Asp Gly Ser Gly Pro 
465                 470                 475                 480 


Asp Gln Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Lys Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly Ala Pro Thr Tyr Ser 
        515                 520                 525             


Trp Gly Ala Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu Arg Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Ile Asn Tyr 
    610                 615                 620                 


Thr Val Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Glu Ala Ala Cys Asn Trp Thr Arg Gly Asp Arg Cys Asn Leu Asp Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Ile Ala Ser Trp Ala Ile Lys Trp Glu Tyr Val Val 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Val Glu Ala Ala Leu Glu Asn Leu Val 
            740                 745                 750         


Val Leu Asn Ala Ala Ser Leu Ala Gly Thr His Gly Leu Val Ser Phe 
        755                 760                 765             


Leu Val Phe Phe Cys Phe Ala Trp Tyr Leu Lys Gly Lys Trp Val Pro 
    770                 775                 780                 


Gly Ala Val Tyr Ala Leu Tyr Gly Met Trp Pro Leu Leu Leu Leu Leu 
785                 790                 795                 800 


Leu Ala Leu Pro Gln Arg Ala Tyr Ala Leu Asp Thr Glu Val Ala Ala 
                805                 810                 815     


Ser Cys Gly Gly Val Val Leu Val Gly Leu Met Ala Leu Thr Leu Ser 
            820                 825                 830         


Pro Tyr Tyr Lys Arg Tyr Ile Ser Trp Cys Leu Trp Trp Leu Gln Tyr 
        835                 840                 845             


Phe Leu Thr Arg Ile Glu Ala Gln Leu His Val Trp Ile Pro Pro Leu 
    850                 855                 860                 


Asn Val Arg Gly Gly Arg Asp Ala Val Ile Leu Leu Met Cys Val Val 
865                 870                 875                 880 


His Pro Ala Leu Val Phe Asp Ile Thr Lys Leu Leu Leu Ala Ala Phe 
                885                 890                 895     


Gly Pro Leu Trp Ile Leu Gln Ala Ser Leu Leu Lys Val Pro Tyr Phe 
            900                 905                 910         


Val Arg Val Gln Gly Leu Leu Arg Ile Cys Ala Leu Ala Arg Lys Met 
        915                 920                 925             


Ala Gly Gly His Tyr Val Gln Met Ala Ile Ile Lys Leu Gly Ala Leu 
    930                 935                 940                 


Thr Gly Thr Tyr Val Tyr Asn His Leu Thr Pro Leu Arg Asp Trp Ala 
945                 950                 955                 960 


His Asn Gly Leu Arg Asp Leu Ala Val Ala Val Glu Pro Val Val Phe 
                965                 970                 975     


Ser Arg Met Glu Thr Lys Leu Ile Thr Trp Gly Ala Asp Thr Ala Ala 
            980                 985                 990         


Cys Gly Asp Ile Ile Asn Gly Leu  Pro Val Ser Ala Arg  Arg Gly Arg 
        995                 1000                 1005             


Glu Ile  Leu Leu Gly Pro Ala  Asp Gly Met Val Ser  Lys Gly Trp 
    1010                 1015                 1020             


Arg Leu  Leu Ala Pro Ile Thr  Ala Tyr Ala Gln Gln  Thr Arg Gly 
    1025                 1030                 1035             


Leu Leu  Gly Cys Ile Ile Thr  Ser Leu Thr Gly Arg  Asp Lys Asn 
    1040                 1045                 1050             


Gln Val  Glu Gly Glu Ile Gln  Ile Val Ser Thr Ala  Ala Gln Thr 
    1055                 1060                 1065             


Phe Leu  Ala Thr Cys Ile Asn  Gly Val Cys Trp Thr  Val Tyr His 
    1070                 1075                 1080             


Gly Ala  Gly Thr Arg Thr Ile  Ala Ser Pro Lys Gly  Pro Val Ile 
    1085                 1090                 1095             


Gln Met  Tyr Thr Asn Val Asp  Lys Asp Leu Val Gly  Trp Pro Ala 
    1100                 1105                 1110             


Pro Gln  Gly Ala Arg Ser Leu  Thr Pro Cys Thr Cys  Gly Ser Ser 
    1115                 1120                 1125             


Asp Leu  Tyr Leu Val Thr Arg  His Ala Asp Val Ile  Pro Val Arg 
    1130                 1135                 1140             


Arg Arg  Gly Asp Ser Arg Gly  Ser Leu Leu Ser Pro  Arg Pro Ile 
    1145                 1150                 1155             


Ser Tyr  Leu Lys Gly Ser Ser  Gly Gly Pro Leu Leu  Cys Pro Ala 
    1160                 1165                 1170             


Gly His  Ala Val Gly Leu Phe  Arg Ala Ala Val Cys  Thr Arg Gly 
    1175                 1180                 1185             


Val Ala  Lys Ala Val Asp Phe  Ile Pro Val Glu Asn  Leu Glu Thr 
    1190                 1195                 1200             


Thr Met  Arg Ser Pro Val Phe  Thr Asp Asn Ser Ser  Pro Pro Ala 
    1205                 1210                 1215             


Val Pro  Gln Ser Phe Gln Val  Gly His Leu His Ala  Pro Thr Gly 
    1220                 1225                 1230             


Ser Gly  Lys Ser Thr Lys Val  Pro Ala Ala Tyr Ala  Ala Gln Gly 
    1235                 1240                 1245             


Tyr Lys  Val Leu Val Leu Asn  Pro Ser Val Ala Ala  Thr Leu Gly 
    1250                 1255                 1260             


Phe Gly  Ala Tyr Met Ser Lys  Ala His Gly Val Asp  Pro Asn Ile 
    1265                 1270                 1275             


Arg Thr  Gly Val Arg Thr Ile  Thr Thr Gly Ser Pro  Ile Thr Tyr 
    1280                 1285                 1290             


Ser Thr  Tyr Gly Lys Phe Leu  Ala Asp Gly Gly Cys  Ser Gly Gly 
    1295                 1300                 1305             


Ala Tyr  Asp Ile Ile Ile Cys  Asp Glu Cys His Ser  Thr Asp Ala 
    1310                 1315                 1320             


Thr Ser  Ile Leu Gly Ile Gly  Thr Val Leu Asp Gln  Ala Glu Thr 
    1325                 1330                 1335             


Ala Gly  Ala Arg Leu Val Val  Leu Ala Thr Ala Thr  Pro Pro Gly 
    1340                 1345                 1350             


Ser Ile  Thr Val Pro His Pro  Asn Ile Glu Glu Val  Ala Leu Ser 
    1355                 1360                 1365             


Thr Thr  Gly Glu Ile Pro Phe  Tyr Gly Lys Ala Ile  Pro Leu Glu 
    1370                 1375                 1380             


Ala Ile  Lys Gly Gly Arg His  Leu Ile Phe Cys His  Ser Lys Lys 
    1385                 1390                 1395             


Lys Cys  Asp Glu Leu Ala Ala  Lys Leu Val Ala Leu  Gly Ile Asn 
    1400                 1405                 1410             


Ala Val  Ala Tyr Tyr Arg Gly  Leu Asp Val Ser Val  Ile Pro Thr 
    1415                 1420                 1425             


Ser Gly  Asp Val Val Val Val  Ala Thr Asp Ala Leu  Met Thr Gly 
    1430                 1435                 1440             


Tyr Thr  Gly Asp Phe Asp Ser  Val Ile Asp Cys Asn  Thr Cys Val 
    1445                 1450                 1455             


Thr Gln  Thr Val Asp Leu Ser  Leu Asp Pro Thr Phe  Thr Ile Glu 
    1460                 1465                 1470             


Thr Thr  Thr Leu Pro Gln Asp  Ala Val Ser Arg Thr  Gln Arg Arg 
    1475                 1480                 1485             


Gly Arg  Thr Gly Arg Gly Lys  Pro Gly Ile Tyr Arg  Phe Val Ala 
    1490                 1495                 1500             


Leu Gly  Glu Arg Pro Ser Gly  Met Phe Asp Ser Ser  Val Leu Cys 
    1505                 1510                 1515             


Glu Cys  Tyr Asp Ala Gly Cys  Ala Trp Tyr Glu Leu  Thr Pro Ala 
    1520                 1525                 1530             


Glu Thr  Thr Val Arg Leu Arg  Ala Tyr Met Asn Thr  Pro Gly Leu 
    1535                 1540                 1545             


Pro Val  Cys Gln Asp His Leu  Glu Phe Trp Glu Gly  Val Phe Thr 
    1550                 1555                 1560             


Gly Leu  Thr His Ile Asp Ala  His Phe Leu Ser Gln  Thr Lys Gln 
    1565                 1570                 1575             


Ser Gly  Glu Asn Phe Pro Tyr  Leu Val Ala Tyr Gln  Ala Thr Val 
    1580                 1585                 1590             


Cys Ala  Arg Ala Gln Ala Pro  Pro Pro Ser Trp Asp  Gln Met Trp 
    1595                 1600                 1605             


Lys Cys  Leu Thr Arg Leu Lys  Pro Thr Leu His Gly  Pro Thr Pro 
    1610                 1615                 1620             


Leu Leu  Tyr Arg Leu Gly Ala  Val Gln Asn Glu Val  Thr Leu Thr 
    1625                 1630                 1635             


His Pro  Ile Thr Lys Tyr Ile  Met Thr Cys Met Ser  Ala Asp Leu 
    1640                 1645                 1650             


Glu Val  Val Thr Ser Thr Trp  Val Leu Val Gly Gly  Val Leu Ala 
    1655                 1660                 1665             


Ala Leu  Ala Ser Tyr Cys Leu  Ser Thr Gly Cys Val  Val Ile Val 
    1670                 1675                 1680             


Gly Arg  Ile Val Leu Ser Gly  Lys Pro Ala Ile Ile  Pro Asp Arg 
    1685                 1690                 1695             


Glu Val  Leu Tyr Arg Glu Phe  Asp Glu Met Glu Glu  Cys Ser Gln 
    1700                 1705                 1710             


His Leu  Pro Tyr Ile Glu Gln  Gly Met Met Leu Ala  Glu Gln Phe 
    1715                 1720                 1725             


Lys Gln  Lys Ala Leu Gly Leu  Leu Gln Thr Ala Ser  Arg Gln Ala 
    1730                 1735                 1740             


Glu Val  Val Ala Pro Ala Val  Gln Thr Asn Trp Gln  Lys Leu Glu 
    1745                 1750                 1755             


Ala Phe  Trp Ala Lys His Met  Trp Asn Phe Ile Ser  Gly Ile Gln 
    1760                 1765                 1770             


Tyr Leu  Ala Gly Leu Ser Thr  Leu Pro Gly Asn Pro  Ala Ile Ala 
    1775                 1780                 1785             


Ser Leu  Met Ala Phe Thr Ala  Ala Val Thr Ser Pro  Leu Thr Thr 
    1790                 1795                 1800             


Ser Gln  Thr Leu Leu Phe Asn  Ile Leu Gly Gly Trp  Val Ala Ala 
    1805                 1810                 1815             


Gln Leu  Ala Ala Pro Gly Ala  Ala Thr Ala Phe Val  Gly Ala Gly 
    1820                 1825                 1830             


Leu Ala  Gly Ala Ala Ile Gly  Ser Val Gly Leu Gly  Lys Val Leu 
    1835                 1840                 1845             


Val Asp  Ile Leu Ala Gly Tyr  Gly Ala Gly Val Ala  Gly Ala Leu 
    1850                 1855                 1860             


Val Ala  Phe Lys Ile Met Ser  Gly Glu Val Pro Ser  Thr Glu Asp 
    1865                 1870                 1875             


Leu Val  Asn Leu Leu Pro Ala  Ile Leu Ser Pro Gly  Ala Leu Val 
    1880                 1885                 1890             


Val Gly  Val Val Cys Ala Ala  Ile Leu Arg Arg His  Val Gly Pro 
    1895                 1900                 1905             


Gly Glu  Gly Ala Val Gln Trp  Met Asn Arg Leu Ile  Ala Phe Ala 
    1910                 1915                 1920             


Ser Arg  Gly Asn His Val Ser  Pro Thr His Tyr Val  Pro Glu Ser 
    1925                 1930                 1935             


Asp Ala  Ala Ala Arg Val Thr  Thr Ile Leu Ser Ser  Leu Thr Val 
    1940                 1945                 1950             


Thr Gln  Leu Leu Arg Arg Leu  His Gln Trp Ile Ser  Ser Glu Cys 
    1955                 1960                 1965             


Thr Thr  Pro Cys Ser Gly Ser  Trp Leu Arg Asp Ile  Trp Asp Trp 
    1970                 1975                 1980             


Ile Cys  Glu Val Leu Ser Asp  Phe Lys Thr Trp Leu  Lys Ala Lys 
    1985                 1990                 1995             


Leu Met  Pro Gln Leu Pro Gly  Ile Pro Phe Val Ser  Cys Gln Arg 
    2000                 2005                 2010             


Gly Tyr  Lys Gly Val Trp Arg  Gly Asp Gly Ile Met  His Thr Arg 
    2015                 2020                 2025             


Cys His  Cys Gly Ala Glu Ile  Thr Gly His Val Lys  Asn Gly Thr 
    2030                 2035                 2040             


Met Arg  Ile Val Gly Pro Lys  Thr Cys Arg Asn Met  Trp Ser Gly 
    2045                 2050                 2055             


Thr Phe  Pro Ile Asn Ala Tyr  Thr Thr Gly Pro Cys  Thr Pro Leu 
    2060                 2065                 2070             


Pro Ala  Pro Asn Tyr Thr Phe  Ala Leu Trp Arg Val  Ser Ala Glu 
    2075                 2080                 2085             


Glu Tyr  Val Glu Ile Arg Gln  Val Gly Asp Phe His  Tyr Val Thr 
    2090                 2095                 2100             


Gly Met  Thr Thr Asp Asn Leu  Lys Cys Pro Cys Gln  Val Pro Ser 
    2105                 2110                 2115             


Pro Glu  Phe Phe Thr Glu Leu  Asp Gly Val Arg Leu  His Arg Phe 
    2120                 2125                 2130             


Ala Pro  Pro Cys Lys Pro Leu  Leu Arg Glu Glu Val  Ser Phe Arg 
    2135                 2140                 2145             


Val Gly  Leu His Glu Tyr Pro  Val Gly Ser Gln Leu  Pro Cys Glu 
    2150                 2155                 2160             


Pro Glu  Pro Asp Val Ala Val  Leu Thr Ser Met Leu  Thr Asp Pro 
    2165                 2170                 2175             


Ser His  Ile Thr Ala Glu Ala  Ala Gly Arg Arg Leu  Ala Arg Gly 
    2180                 2185                 2190             


Ser Pro  Pro Ser Met Ala Ser  Ser Ser Ala Ser Gln  Leu Ser Ala 
    2195                 2200                 2205             


Pro Ser  Leu Arg Ala Thr Cys  Thr Thr Asn His Asp  Ser Pro Asp 
    2210                 2215                 2220             


Ala Glu  Leu Ile Glu Ala Asn  Leu Leu Trp Arg Gln  Glu Met Gly 
    2225                 2230                 2235             


Gly Asn  Ile Thr Arg Val Glu  Ser Glu Asn Lys Val  Val Ile Leu 
    2240                 2245                 2250             


Asp Ser  Phe Asp Pro Leu Val  Ala Glu Glu Asp Glu  Arg Glu Val 
    2255                 2260                 2265             


Ser Val  Pro Ala Glu Ile Leu  Arg Lys Ser Arg Lys  Phe Thr Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ile Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Pro  Trp Lys Lys Pro Asp  Tyr Glu Pro Pro Val  Val His Gly 
    2300                 2305                 2310             


Cys Pro  Leu Pro Pro Pro Gln  Ser Pro Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Lys Lys  Arg Thr Val Ile Leu  Thr Glu Ser Thr Leu  Pro Thr Ala 
    2330                 2335                 2340             


Leu Ala  Glu Leu Ala Thr Lys  Ser Phe Gly Ser Ser  Ser Thr Ser 
    2345                 2350                 2355             


Gly Ile  Thr Gly Asp Asp Thr  Thr Thr Ser Pro Glu  Pro Ala Ser 
    2360                 2365                 2370             


Ser Ser  Cys Pro Pro Asp Ser  Asp Ala Glu Ser Tyr  Ser Ser Met 
    2375                 2380                 2385             


Pro Pro  Leu Glu Gly Glu Pro  Gly Asp Pro Asp Leu  Ser Asp Gly 
    2390                 2395                 2400             


Ser Trp  Ser Thr Val Ser Ser  Glu Ala Asp Lys Glu  Asp Val Val 
    2405                 2410                 2415             


Cys Cys  Ser Met Ser Tyr Thr  Trp Thr Gly Ala Leu  Val Thr Pro 
    2420                 2425                 2430             


Cys Ala  Ala Glu Glu Gln Lys  Leu Pro Ile Asn Ala  Leu Ser Asn 
    2435                 2440                 2445             


Ser Leu  Leu Arg His His Asn  Leu Val Tyr Ser Thr  Thr Ser Arg 
    2450                 2455                 2460             


Ser Ala  Cys Gln Arg Gln Lys  Lys Val Thr Phe Asp  Arg Leu Gln 
    2465                 2470                 2475             


Val Leu  Asp Ser His Tyr Gln  Asp Val Leu Lys Glu  Val Lys Ala 
    2480                 2485                 2490             


Ala Ala  Ser Lys Val Lys Ala  Asn Leu Leu Ser Val  Glu Glu Ala 
    2495                 2500                 2505             


Cys Ser  Leu Thr Pro Pro His  Ser Ala Lys Ser Lys  Phe Gly Tyr 
    2510                 2515                 2520             


Gly Ala  Lys Asp Val Arg Cys  His Ala Arg Lys Ala  Val Asn His 
    2525                 2530                 2535             


Ile Asn  Ser Val Trp Lys Asp  Leu Leu Glu Asp Ser  Val Thr Pro 
    2540                 2545                 2550             


Ile Asp  Thr Thr Ile Met Ala  Lys Asn Glu Val Phe  Cys Val Gln 
    2555                 2560                 2565             


Pro Glu  Lys Gly Gly Arg Lys  Pro Ala Arg Leu Ile  Val Phe Pro 
    2570                 2575                 2580             


Asp Leu  Gly Val Arg Val Cys  Glu Lys Met Ala Leu  Tyr Asp Val 
    2585                 2590                 2595             


Val Ser  Lys Leu Pro Leu Ala  Val Met Gly Ser Ser  Tyr Gly Phe 
    2600                 2605                 2610             


Gln Tyr  Ser Pro Gly Gln Arg  Val Glu Phe Leu Val  Gln Ala Trp 
    2615                 2620                 2625             


Lys Ser  Lys Lys Thr Pro Met  Gly Phe Ser Tyr Asp  Thr Arg Cys 
    2630                 2635                 2640             


Phe Asp  Ser Thr Val Thr Glu  Asn Asp Ile Arg Thr  Glu Glu Ala 
    2645                 2650                 2655             


Ile Tyr  Gln Cys Cys Asp Leu  Asp Pro Gln Ala Arg  Val Ala Ile 
    2660                 2665                 2670             


Lys Ser  Leu Thr Glu Arg Leu  Tyr Val Gly Gly Pro  Leu Thr Asn 
    2675                 2680                 2685             


Ser Arg  Gly Glu Asn Cys Gly  Tyr Arg Arg Cys Arg  Ala Ser Gly 
    2690                 2695                 2700             


Val Leu  Thr Thr Ser Cys Gly  Asn Thr Leu Thr Cys  Tyr Ile Lys 
    2705                 2710                 2715             


Ala Arg  Ala Ala Cys Arg Ala  Ala Gly Leu Gln Asp  Cys Thr Met 
    2720                 2725                 2730             


Leu Val  Cys Gly Asp Asp Leu  Val Val Ile Cys Glu  Ser Ala Gly 
    2735                 2740                 2745             


Val Gln  Glu Asp Ala Ala Ser  Leu Arg Ala Phe Thr  Glu Ala Met 
    2750                 2755                 2760             


Thr Arg  Tyr Ser Ala Pro Pro  Gly Asp Pro Pro Gln  Pro Glu Tyr 
    2765                 2770                 2775             


Asp Leu  Glu Leu Ile Thr Ser  Cys Ser Ser Asn Val  Ser Val Ala 
    2780                 2785                 2790             


His Asp  Gly Ala Gly Lys Arg  Val Tyr Tyr Leu Thr  Arg Asp Pro 
    2795                 2800                 2805             


Thr Thr  Pro Leu Ala Arg Ala  Ala Trp Glu Thr Ala  Arg His Thr 
    2810                 2815                 2820             


Pro Val  Asn Ser Trp Leu Gly  Asn Ile Ile Met Phe  Ala Pro Thr 
    2825                 2830                 2835             


Leu Trp  Ala Arg Met Ile Leu  Met Thr His Phe Phe  Ser Val Leu 
    2840                 2845                 2850             


Ile Ala  Arg Asp Gln Leu Glu  Gln Ala Leu Asp Cys  Glu Ile Tyr 
    2855                 2860                 2865             


Gly Ala  Cys Tyr Ser Ile Glu  Pro Leu Asp Leu Pro  Pro Ile Ile 
    2870                 2875                 2880             


Gln Arg  Leu His Gly Leu Ser  Ala Phe Ser Leu His  Ser Tyr Ser 
    2885                 2890                 2895             


Pro Gly  Glu Ile Asn Arg Val  Ala Ala Cys Leu Arg  Lys Leu Gly 
    2900                 2905                 2910             


Val Pro  Pro Leu Arg Ala Trp  Arg His Arg Ala Arg  Asn Val Arg 
    2915                 2920                 2925             


Ala Arg  Leu Leu Ser Arg Gly  Gly Arg Ala Ala Ile  Cys Gly Lys 
    2930                 2935                 2940             


Tyr Leu  Phe Asn Trp Ala Val  Arg Thr Lys Leu Lys  Leu Thr Pro 
    2945                 2950                 2955             


Ile Ala  Ala Ala Gly Arg Leu  Asp Leu Ser Gly Trp  Phe Thr Ala 
    2960                 2965                 2970             


Gly Tyr  Ser Gly Gly Gly Ile  Phe His Ser Val Ser  His Ala Arg 
    2975                 2980                 2985             


Pro Arg  Trp Phe Trp Phe Cys  Leu Leu Leu Leu Ala  Ala Gly Val 
    2990                 2995                 3000             


Gly Ile  Tyr Leu Leu Pro Asn  Arg 
    3005                 3010     


<210>  154
<211>  3011
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  plasmid

<400>  154

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Gly Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Thr Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Phe Glu Ala Ala Asp Ala Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Val Thr Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Thr Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Ser Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Ala Leu Leu Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Met Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr Tyr Val Thr Gly Gly Ser Ala Ala Arg Thr Thr Ala Gly Leu Ala 
385                 390                 395                 400 


Ser Leu Phe Ser Pro Gly Ala Lys Gln Asn Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Asn Thr Gly Trp Ile Ala Gly Leu Phe Tyr His His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Ser Glu Arg Leu Ala Ser Cys Arg Pro Leu Thr Asp 
    450                 455                 460                 


Phe Ala Gln Gly Trp Gly Pro Ile Ser His Ala Asp Gly Ser Gly Pro 
465                 470                 475                 480 


Asp Gln Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Lys Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly Ala Pro Thr Tyr Ser 
        515                 520                 525             


Trp Gly Ala Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu Arg Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Ile Asn Tyr 
    610                 615                 620                 


Thr Val Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Glu Ala Ala Cys Asn Trp Thr Arg Gly Asp Arg Cys Asn Leu Asp Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Ile Ala Ser Trp Ala Ile Lys Trp Glu Tyr Val Val 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Val Glu Ala Ala Leu Glu Asn Leu Val 
            740                 745                 750         


Val Leu Asn Ala Ala Ser Leu Ala Gly Thr His Gly Leu Val Ser Phe 
        755                 760                 765             


Leu Val Phe Phe Cys Phe Ala Trp Tyr Leu Lys Gly Lys Trp Val Pro 
    770                 775                 780                 


Gly Ala Val Tyr Ala Leu Tyr Gly Met Trp Pro Leu Leu Leu Leu Leu 
785                 790                 795                 800 


Leu Ala Leu Pro Gln Arg Ala Tyr Ala Leu Asp Thr Glu Val Ala Ala 
                805                 810                 815     


Ser Cys Gly Gly Val Val Leu Val Gly Leu Met Ala Leu Thr Leu Ser 
            820                 825                 830         


Pro Tyr Tyr Lys Arg Tyr Ile Ser Trp Cys Leu Trp Trp Leu Gln Tyr 
        835                 840                 845             


Phe Leu Thr Arg Ile Glu Ala Gln Leu His Val Trp Ile Pro Pro Leu 
    850                 855                 860                 


Asn Val Arg Gly Gly Arg Asp Ala Val Ile Leu Leu Met Cys Val Val 
865                 870                 875                 880 


His Pro Ala Leu Val Phe Asp Ile Thr Lys Leu Leu Leu Ala Ala Phe 
                885                 890                 895     


Gly Pro Leu Trp Ile Leu Gln Ala Ser Leu Leu Lys Val Pro Tyr Phe 
            900                 905                 910         


Val Arg Val Gln Gly Leu Leu Arg Ile Cys Ala Leu Ala Arg Lys Met 
        915                 920                 925             


Ala Gly Gly His Tyr Val Gln Met Ala Ile Ile Lys Leu Gly Ala Leu 
    930                 935                 940                 


Thr Gly Thr Tyr Val Tyr Asn His Leu Thr Pro Leu Arg Asp Trp Ala 
945                 950                 955                 960 


His Asn Gly Leu Arg Asp Leu Ala Val Ala Val Glu Pro Val Val Phe 
                965                 970                 975     


Ser Arg Met Glu Thr Lys Leu Ile Thr Trp Gly Ala Asp Thr Ala Ala 
            980                 985                 990         


Cys Gly Asp Ile Ile Asn Gly Leu  Pro Val Ser Ala Arg  Arg Gly Arg 
        995                 1000                 1005             


Glu Ile  Leu Leu Gly Pro Ala  Asp Gly Met Val Ser  Lys Gly Trp 
    1010                 1015                 1020             


Arg Leu  Leu Ala Pro Ile Thr  Ala Tyr Ala Gln Gln  Thr Arg Gly 
    1025                 1030                 1035             


Leu Leu  Gly Cys Ile Ile Thr  Ser Leu Thr Gly Arg  Asp Lys Asn 
    1040                 1045                 1050             


Gln Val  Glu Gly Glu Ile Gln  Ile Val Ser Thr Ala  Ala Gln Thr 
    1055                 1060                 1065             


Phe Leu  Ala Thr Cys Ile Asn  Gly Val Cys Trp Thr  Val Tyr His 
    1070                 1075                 1080             


Gly Ala  Gly Thr Arg Thr Ile  Ala Ser Pro Lys Gly  Pro Val Ile 
    1085                 1090                 1095             


Gln Met  Tyr Thr Asn Val Asp  Lys Asp Leu Val Gly  Trp Pro Ala 
    1100                 1105                 1110             


Pro Gln  Gly Ala Arg Ser Leu  Thr Pro Cys Thr Cys  Gly Ser Ser 
    1115                 1120                 1125             


Asp Leu  Tyr Leu Val Thr Arg  His Ala Asp Val Ile  Pro Val Arg 
    1130                 1135                 1140             


Arg Arg  Gly Asp Ser Arg Gly  Ser Leu Leu Ser Pro  Arg Pro Ile 
    1145                 1150                 1155             


Ser Tyr  Leu Lys Gly Ser Ser  Gly Gly Pro Leu Leu  Cys Pro Ala 
    1160                 1165                 1170             


Gly His  Ala Val Gly Leu Phe  Arg Ala Ala Val Cys  Thr Arg Gly 
    1175                 1180                 1185             


Val Ala  Lys Ala Val Asp Phe  Ile Pro Val Glu Asn  Leu Glu Thr 
    1190                 1195                 1200             


Thr Met  Arg Ser Pro Val Phe  Thr Asp Asn Ser Ser  Pro Pro Ala 
    1205                 1210                 1215             


Val Pro  Gln Ser Phe Gln Val  Gly His Leu His Ala  Pro Thr Gly 
    1220                 1225                 1230             


Ser Gly  Lys Ser Thr Lys Val  Pro Ala Ala Tyr Ala  Ala Gln Gly 
    1235                 1240                 1245             


Tyr Lys  Val Leu Val Leu Asn  Pro Ser Val Ala Ala  Thr Leu Gly 
    1250                 1255                 1260             


Phe Gly  Ala Tyr Met Ser Lys  Ala His Gly Val Asp  Pro Asn Ile 
    1265                 1270                 1275             


Arg Thr  Gly Val Arg Thr Ile  Thr Thr Gly Ser Pro  Ile Thr Tyr 
    1280                 1285                 1290             


Ser Thr  Tyr Gly Lys Phe Leu  Ala Asp Gly Gly Cys  Ser Gly Gly 
    1295                 1300                 1305             


Ala Tyr  Asp Ile Ile Ile Cys  Asp Glu Cys His Ser  Thr Asp Ala 
    1310                 1315                 1320             


Thr Ser  Ile Leu Gly Ile Gly  Thr Val Leu Asp Gln  Ala Glu Thr 
    1325                 1330                 1335             


Ala Gly  Ala Arg Leu Val Val  Leu Ala Thr Ala Thr  Pro Pro Gly 
    1340                 1345                 1350             


Ser Ile  Thr Val Pro His Pro  Asn Ile Glu Glu Val  Ala Leu Ser 
    1355                 1360                 1365             


Thr Thr  Gly Glu Ile Pro Phe  Tyr Gly Lys Ala Ile  Pro Leu Glu 
    1370                 1375                 1380             


Ala Ile  Lys Gly Gly Arg His  Leu Ile Phe Cys His  Ser Lys Lys 
    1385                 1390                 1395             


Lys Cys  Asp Glu Leu Ala Ala  Lys Leu Val Ala Leu  Gly Ile Asn 
    1400                 1405                 1410             


Ala Val  Ala Tyr Tyr Arg Gly  Leu Asp Val Ser Val  Ile Pro Thr 
    1415                 1420                 1425             


Ser Gly  Asp Val Val Val Val  Ala Thr Asp Ala Leu  Met Thr Gly 
    1430                 1435                 1440             


Tyr Thr  Gly Asp Phe Asp Ser  Val Ile Asp Cys Asn  Thr Cys Val 
    1445                 1450                 1455             


Thr Gln  Thr Val Asp Leu Ser  Leu Asp Pro Thr Phe  Thr Ile Glu 
    1460                 1465                 1470             


Thr Thr  Thr Leu Pro Gln Asp  Ala Val Ser Arg Thr  Gln Arg Arg 
    1475                 1480                 1485             


Gly Arg  Thr Gly Arg Gly Lys  Pro Gly Ile Tyr Arg  Phe Val Ala 
    1490                 1495                 1500             


Leu Gly  Glu Arg Pro Ser Gly  Met Phe Asp Ser Ser  Val Leu Cys 
    1505                 1510                 1515             


Glu Cys  Tyr Asp Ala Gly Cys  Ala Trp Tyr Glu Leu  Thr Pro Ala 
    1520                 1525                 1530             


Glu Thr  Thr Val Arg Leu Arg  Ala Tyr Met Asn Thr  Pro Gly Leu 
    1535                 1540                 1545             


Pro Val  Cys Gln Asp His Leu  Glu Phe Trp Glu Gly  Val Phe Thr 
    1550                 1555                 1560             


Gly Leu  Thr His Ile Asp Ala  His Phe Leu Ser Gln  Thr Lys Gln 
    1565                 1570                 1575             


Ser Gly  Glu Asn Phe Pro Tyr  Leu Val Ala Tyr Gln  Ala Thr Val 
    1580                 1585                 1590             


Cys Ala  Arg Ala Gln Ala Pro  Pro Pro Ser Trp Asp  Gln Met Trp 
    1595                 1600                 1605             


Lys Cys  Leu Thr Arg Leu Lys  Pro Thr Leu His Gly  Pro Thr Pro 
    1610                 1615                 1620             


Leu Leu  Tyr Arg Leu Gly Ala  Val Gln Asn Glu Val  Thr Leu Thr 
    1625                 1630                 1635             


His Pro  Ile Thr Lys Tyr Ile  Met Thr Cys Met Ser  Ala Asp Leu 
    1640                 1645                 1650             


Glu Val  Val Thr Ser Thr Trp  Val Leu Val Gly Gly  Val Leu Ala 
    1655                 1660                 1665             


Ala Leu  Ala Ser Tyr Cys Leu  Ser Thr Gly Cys Val  Val Ile Val 
    1670                 1675                 1680             


Gly Arg  Ile Val Leu Ser Gly  Lys Pro Ala Ile Ile  Pro Asp Arg 
    1685                 1690                 1695             


Glu Val  Leu Tyr Arg Glu Phe  Asp Glu Met Glu Glu  Cys Ser Gln 
    1700                 1705                 1710             


His Leu  Pro Tyr Ile Glu Gln  Gly Met Met Leu Ala  Glu Gln Phe 
    1715                 1720                 1725             


Lys Gln  Lys Ala Leu Gly Leu  Leu Gln Thr Ala Ser  Arg Gln Ala 
    1730                 1735                 1740             


Glu Val  Val Ala Pro Ala Val  Gln Thr Asn Trp Gln  Lys Leu Glu 
    1745                 1750                 1755             


Ala Phe  Trp Ala Lys His Met  Trp Asn Phe Ile Ser  Gly Ile His 
    1760                 1765                 1770             


Tyr Leu  Ala Gly Leu Ser Thr  Leu Pro Gly Asn Pro  Ala Ile Ala 
    1775                 1780                 1785             


Ser Leu  Met Ala Phe Thr Ala  Ala Val Thr Ser Pro  Leu Thr Thr 
    1790                 1795                 1800             


Ser Gln  Thr Leu Leu Phe Asn  Ile Leu Gly Gly Trp  Val Ala Ala 
    1805                 1810                 1815             


Gln Leu  Ala Ala Pro Gly Ala  Ala Thr Ala Phe Val  Gly Ala Gly 
    1820                 1825                 1830             


Leu Ala  Gly Ala Ala Ile Gly  Ser Val Gly Leu Gly  Lys Val Leu 
    1835                 1840                 1845             


Val Asp  Ile Leu Ala Gly Tyr  Gly Ala Gly Val Ala  Gly Ala Leu 
    1850                 1855                 1860             


Val Ala  Phe Lys Ile Met Ser  Gly Glu Val Pro Ser  Thr Glu Asp 
    1865                 1870                 1875             


Leu Val  Asn Leu Leu Pro Ala  Ile Leu Ser Pro Gly  Ala Leu Val 
    1880                 1885                 1890             


Val Gly  Val Val Cys Ala Ala  Ile Leu Arg Arg His  Val Gly Pro 
    1895                 1900                 1905             


Gly Glu  Gly Ala Val Gln Trp  Met Asn Arg Leu Ile  Ala Phe Ala 
    1910                 1915                 1920             


Ser Arg  Gly Asn His Val Ser  Pro Thr His Tyr Val  Pro Glu Ser 
    1925                 1930                 1935             


Asp Ala  Ala Ala Arg Val Thr  Thr Ile Leu Ser Ser  Leu Thr Val 
    1940                 1945                 1950             


Thr Gln  Leu Leu Arg Arg Leu  His Gln Trp Ile Ser  Ser Glu Cys 
    1955                 1960                 1965             


Thr Thr  Pro Cys Ser Gly Ser  Trp Leu Arg Asp Ile  Trp Asp Trp 
    1970                 1975                 1980             


Ile Cys  Glu Val Leu Ser Asp  Phe Lys Thr Trp Leu  Lys Ala Lys 
    1985                 1990                 1995             


Leu Met  Pro Gln Leu Pro Gly  Ile Pro Phe Val Ser  Cys Gln Arg 
    2000                 2005                 2010             


Gly Tyr  Lys Gly Val Trp Arg  Gly Asp Gly Ile Met  His Thr Arg 
    2015                 2020                 2025             


Cys His  Cys Gly Ala Glu Ile  Thr Gly His Val Lys  Asn Gly Thr 
    2030                 2035                 2040             


Met Arg  Ile Val Gly Pro Lys  Thr Cys Arg Asn Met  Trp Ser Gly 
    2045                 2050                 2055             


Thr Phe  Pro Ile Asn Ala Tyr  Thr Thr Gly Pro Cys  Thr Pro Leu 
    2060                 2065                 2070             


Pro Ala  Pro Asn Tyr Thr Phe  Ala Leu Trp Arg Val  Ser Ala Glu 
    2075                 2080                 2085             


Glu Tyr  Val Glu Ile Arg Gln  Val Gly Asp Phe His  Tyr Val Thr 
    2090                 2095                 2100             


Gly Met  Thr Thr Asp Asn Leu  Lys Cys Pro Cys Gln  Val Pro Ser 
    2105                 2110                 2115             


Pro Glu  Phe Phe Thr Glu Leu  Asp Gly Val Arg Leu  His Arg Phe 
    2120                 2125                 2130             


Ala Pro  Pro Cys Lys Pro Leu  Leu Arg Glu Glu Val  Ser Phe Arg 
    2135                 2140                 2145             


Val Gly  Leu His Glu Tyr Pro  Val Gly Ser Gln Leu  Pro Cys Glu 
    2150                 2155                 2160             


Pro Glu  Pro Asp Val Ala Val  Leu Thr Ser Met Leu  Thr Asp Pro 
    2165                 2170                 2175             


Ser His  Ile Thr Ala Glu Ala  Ala Gly Arg Arg Leu  Ala Arg Gly 
    2180                 2185                 2190             


Ser Pro  Pro Ser Met Ala Ser  Ser Ser Ala Ser Gln  Leu Ser Ala 
    2195                 2200                 2205             


Pro Ser  Leu Arg Ala Thr Cys  Thr Thr Asn His Asp  Ser Pro Asp 
    2210                 2215                 2220             


Ala Glu  Leu Ile Glu Ala Asn  Leu Leu Trp Arg Gln  Glu Met Gly 
    2225                 2230                 2235             


Gly Asn  Ile Thr Arg Val Glu  Ser Glu Asn Lys Val  Val Ile Leu 
    2240                 2245                 2250             


Asp Ser  Phe Asp Pro Leu Val  Ala Glu Glu Asp Glu  Arg Glu Val 
    2255                 2260                 2265             


Ser Val  Pro Ala Glu Ile Leu  Arg Lys Ser Arg Lys  Phe Thr Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ile Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Pro  Trp Lys Lys Pro Asp  Tyr Glu Pro Pro Val  Val His Gly 
    2300                 2305                 2310             


Cys Pro  Leu Pro Pro Pro Gln  Ser Pro Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Lys Lys  Arg Thr Val Ile Leu  Thr Glu Ser Thr Leu  Pro Thr Ala 
    2330                 2335                 2340             


Leu Ala  Glu Leu Ala Thr Lys  Ser Phe Gly Ser Ser  Ser Thr Ser 
    2345                 2350                 2355             


Gly Ile  Thr Gly Asp Asp Thr  Thr Thr Ser Pro Glu  Pro Ala Ser 
    2360                 2365                 2370             


Ser Ser  Cys Pro Pro Asp Ser  Asp Ala Glu Ser Tyr  Ser Ser Met 
    2375                 2380                 2385             


Pro Pro  Leu Glu Gly Glu Pro  Gly Asp Pro Asp Leu  Ser Asp Gly 
    2390                 2395                 2400             


Ser Trp  Ser Thr Val Ser Ser  Glu Ala Asp Lys Glu  Asp Val Val 
    2405                 2410                 2415             


Cys Cys  Ser Met Ser Tyr Thr  Trp Thr Gly Ala Leu  Val Thr Pro 
    2420                 2425                 2430             


Cys Ala  Ala Glu Glu Gln Lys  Leu Pro Ile Asn Ala  Leu Ser Asn 
    2435                 2440                 2445             


Ser Leu  Leu Arg His His Asn  Leu Val Tyr Ser Thr  Thr Ser Arg 
    2450                 2455                 2460             


Ser Ala  Cys Gln Arg Gln Lys  Lys Val Thr Phe Asp  Arg Leu Gln 
    2465                 2470                 2475             


Val Leu  Asp Ser His Tyr Gln  Asp Val Leu Lys Glu  Val Lys Ala 
    2480                 2485                 2490             


Ala Ala  Ser Lys Val Lys Ala  Asn Leu Leu Ser Val  Glu Glu Ala 
    2495                 2500                 2505             


Cys Ser  Leu Thr Pro Pro His  Ser Ala Lys Ser Lys  Phe Gly Tyr 
    2510                 2515                 2520             


Gly Ala  Lys Asp Val Arg Cys  His Ala Arg Lys Ala  Val Asn His 
    2525                 2530                 2535             


Ile Asn  Ser Val Trp Lys Asp  Leu Leu Glu Asp Ser  Val Thr Pro 
    2540                 2545                 2550             


Ile Asp  Thr Thr Ile Met Ala  Lys Asn Glu Val Phe  Cys Val Gln 
    2555                 2560                 2565             


Pro Glu  Lys Gly Gly Arg Lys  Pro Ala Arg Leu Ile  Val Phe Pro 
    2570                 2575                 2580             


Asp Leu  Gly Val Arg Val Cys  Glu Lys Met Ala Leu  Tyr Asp Val 
    2585                 2590                 2595             


Val Ser  Lys Leu Pro Leu Ala  Val Met Gly Ser Ser  Tyr Gly Phe 
    2600                 2605                 2610             


Gln Tyr  Ser Pro Gly Gln Arg  Val Glu Phe Leu Val  Gln Ala Trp 
    2615                 2620                 2625             


Lys Ser  Lys Lys Thr Pro Met  Gly Phe Ser Tyr Asp  Thr Arg Cys 
    2630                 2635                 2640             


Phe Asp  Ser Thr Val Thr Glu  Asn Asp Ile Arg Thr  Glu Glu Ala 
    2645                 2650                 2655             


Ile Tyr  Gln Cys Cys Asp Leu  Asp Pro Gln Ala Arg  Val Ala Ile 
    2660                 2665                 2670             


Lys Ser  Leu Thr Glu Arg Leu  Tyr Val Gly Gly Pro  Leu Thr Asn 
    2675                 2680                 2685             


Ser Arg  Gly Glu Asn Cys Gly  Tyr Arg Arg Cys Arg  Ala Ser Gly 
    2690                 2695                 2700             


Val Leu  Thr Thr Ser Cys Gly  Asn Thr Leu Thr Cys  Tyr Ile Lys 
    2705                 2710                 2715             


Ala Arg  Ala Ala Cys Arg Ala  Ala Gly Leu Gln Asp  Cys Thr Met 
    2720                 2725                 2730             


Leu Val  Cys Gly Asp Asp Leu  Val Val Ile Cys Glu  Ser Ala Gly 
    2735                 2740                 2745             


Val Gln  Glu Asp Ala Ala Ser  Leu Arg Ala Phe Thr  Glu Ala Met 
    2750                 2755                 2760             


Thr Arg  Tyr Ser Ala Pro Pro  Gly Asp Pro Pro Gln  Pro Glu Tyr 
    2765                 2770                 2775             


Asp Leu  Glu Leu Ile Thr Ser  Cys Ser Ser Asn Val  Ser Val Ala 
    2780                 2785                 2790             


His Asp  Gly Ala Gly Lys Arg  Val Tyr Tyr Leu Thr  Arg Asp Pro 
    2795                 2800                 2805             


Thr Thr  Pro Leu Ala Arg Ala  Ala Trp Glu Thr Ala  Arg His Thr 
    2810                 2815                 2820             


Pro Val  Asn Ser Trp Leu Gly  Asn Ile Ile Met Phe  Ala Pro Thr 
    2825                 2830                 2835             


Leu Trp  Ala Arg Met Ile Leu  Met Thr His Phe Phe  Ser Val Leu 
    2840                 2845                 2850             


Ile Ala  Arg Asp Gln Leu Glu  Gln Ala Leu Asp Cys  Glu Ile Tyr 
    2855                 2860                 2865             


Gly Ala  Cys Tyr Ser Ile Glu  Pro Leu Asp Leu Pro  Pro Ile Ile 
    2870                 2875                 2880             


Gln Arg  Leu His Gly Leu Ser  Ala Phe Ser Leu His  Ser Tyr Ser 
    2885                 2890                 2895             


Pro Gly  Glu Ile Asn Arg Val  Ala Ala Cys Leu Arg  Lys Leu Gly 
    2900                 2905                 2910             


Val Pro  Pro Leu Arg Ala Trp  Arg His Arg Ala Arg  Asn Val Arg 
    2915                 2920                 2925             


Ala Arg  Leu Leu Ser Arg Gly  Gly Arg Ala Ala Ile  Cys Gly Lys 
    2930                 2935                 2940             


Tyr Leu  Phe Asn Trp Ala Val  Arg Thr Lys Leu Lys  Leu Thr Pro 
    2945                 2950                 2955             


Ile Ala  Ala Ala Gly Arg Leu  Asp Leu Ser Gly Trp  Phe Thr Ala 
    2960                 2965                 2970             


Gly Tyr  Ser Gly Gly Gly Ile  Phe His Ser Val Ser  His Ala Arg 
    2975                 2980                 2985             


Pro Arg  Trp Phe Trp Ser Cys  Leu Leu Leu Leu Ala  Ala Gly Val 
    2990                 2995                 3000             


Gly Ile  Tyr Leu Leu Pro Asn  Arg 
    3005                 3010     


<210>  155
<211>  3011
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  plasmid

<400>  155

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Gly Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Thr Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Phe Glu Ala Ala Asp Ala Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Val Thr Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Thr Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Ser Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Ala Leu Leu Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Met Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr Tyr Val Thr Gly Gly Ser Ala Ala Arg Thr Thr Ala Gly Leu Ala 
385                 390                 395                 400 


Ser Leu Phe Ser Pro Gly Ala Lys Gln Asn Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Asn Thr Gly Trp Ile Ala Gly Leu Phe Tyr His His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Ser Glu Arg Leu Ala Ser Cys Arg Pro Leu Thr Asp 
    450                 455                 460                 


Phe Ala Gln Gly Trp Gly Pro Ile Ser His Ala Asp Gly Ser Gly Pro 
465                 470                 475                 480 


Asp Gln Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Lys Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly Ala Pro Thr Tyr Ser 
        515                 520                 525             


Trp Gly Ala Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu Arg Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Ile Asn Tyr 
    610                 615                 620                 


Thr Val Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Glu Ala Ala Cys Asn Trp Thr Arg Gly Asp Arg Cys Asn Leu Asp Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Ile Ala Ser Trp Ala Ile Lys Trp Glu Tyr Val Val 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Val Glu Ala Ala Leu Glu Asn Leu Val 
            740                 745                 750         


Val Leu Asn Ala Ala Ser Leu Ala Gly Thr His Gly Leu Val Ser Phe 
        755                 760                 765             


Leu Val Phe Phe Cys Phe Ala Trp Tyr Leu Lys Gly Lys Trp Val Pro 
    770                 775                 780                 


Gly Ala Val Tyr Ala Leu Tyr Gly Met Trp Pro Leu Leu Leu Leu Leu 
785                 790                 795                 800 


Leu Ala Leu Pro Gln Arg Ala Tyr Ala Leu Asp Thr Glu Val Ala Ala 
                805                 810                 815     


Ser Cys Gly Gly Val Val Leu Val Gly Leu Met Ala Leu Thr Leu Ser 
            820                 825                 830         


Pro Tyr Tyr Lys Arg Tyr Ile Ser Trp Cys Leu Trp Trp Leu Gln Tyr 
        835                 840                 845             


Phe Leu Thr Arg Ile Glu Ala Gln Leu His Val Trp Ile Pro Pro Leu 
    850                 855                 860                 


Asn Val Arg Gly Gly Arg Asp Ala Val Ile Leu Leu Met Cys Val Val 
865                 870                 875                 880 


His Pro Ala Leu Val Phe Asp Ile Thr Lys Leu Leu Leu Ala Ala Phe 
                885                 890                 895     


Gly Pro Leu Trp Ile Leu Gln Ala Ser Leu Leu Lys Val Pro Tyr Phe 
            900                 905                 910         


Val Arg Val Gln Gly Leu Leu Arg Ile Cys Ala Leu Ala Arg Lys Met 
        915                 920                 925             


Ala Gly Gly His Tyr Val Gln Met Ala Ile Ile Lys Leu Gly Ala Leu 
    930                 935                 940                 


Thr Gly Thr Tyr Val Tyr Asn His Leu Thr Pro Leu Arg Asp Trp Ala 
945                 950                 955                 960 


His Asn Gly Leu Arg Asp Leu Ala Val Ala Val Glu Pro Val Val Phe 
                965                 970                 975     


Ser Arg Met Glu Thr Lys Leu Ile Thr Trp Gly Ala Asp Thr Ala Ala 
            980                 985                 990         


Cys Gly Asp Ile Ile Asn Gly Leu  Pro Val Ser Ala Arg  Arg Gly Arg 
        995                 1000                 1005             


Glu Ile  Leu Leu Gly Pro Ala  Asp Gly Met Val Ser  Lys Gly Trp 
    1010                 1015                 1020             


Arg Leu  Leu Ala Pro Ile Thr  Ala Tyr Ala Gln Gln  Thr Arg Gly 
    1025                 1030                 1035             


Leu Leu  Gly Cys Ile Ile Thr  Ser Leu Thr Gly Arg  Asp Lys Asn 
    1040                 1045                 1050             


Gln Val  Glu Gly Glu Ile Gln  Ile Val Ser Thr Ala  Ala Gln Thr 
    1055                 1060                 1065             


Phe Leu  Ala Thr Cys Ile Asn  Gly Val Cys Trp Thr  Val Tyr His 
    1070                 1075                 1080             


Gly Ala  Gly Thr Arg Thr Ile  Ala Ser Pro Lys Gly  Pro Val Ile 
    1085                 1090                 1095             


Gln Met  Tyr Thr Asn Val Asp  Lys Asp Leu Val Gly  Trp Pro Ala 
    1100                 1105                 1110             


Pro Gln  Gly Ala Arg Ser Leu  Thr Pro Cys Thr Cys  Gly Ser Ser 
    1115                 1120                 1125             


Asp Leu  Tyr Leu Val Thr Arg  His Ala Asp Val Ile  Pro Val Arg 
    1130                 1135                 1140             


Arg Arg  Gly Asp Ser Arg Gly  Ser Leu Leu Ser Pro  Arg Pro Ile 
    1145                 1150                 1155             


Ser Tyr  Leu Lys Gly Ser Ser  Gly Gly Pro Leu Leu  Cys Pro Ala 
    1160                 1165                 1170             


Gly His  Ala Val Gly Leu Phe  Arg Ala Ala Val Cys  Thr Arg Gly 
    1175                 1180                 1185             


Val Ala  Lys Ala Val Asp Phe  Ile Pro Val Glu Asn  Leu Glu Thr 
    1190                 1195                 1200             


Thr Met  Arg Ser Pro Val Phe  Thr Asp Asn Ser Ser  Pro Pro Ala 
    1205                 1210                 1215             


Val Pro  Gln Ser Phe Gln Val  Gly His Leu His Ala  Pro Thr Gly 
    1220                 1225                 1230             


Ser Gly  Lys Ser Thr Lys Val  Pro Ala Ala Tyr Ala  Ala Gln Gly 
    1235                 1240                 1245             


Tyr Lys  Val Leu Val Leu Asn  Pro Ser Val Ala Ala  Thr Leu Gly 
    1250                 1255                 1260             


Phe Gly  Ala Tyr Met Ser Lys  Ala His Gly Val Asp  Pro Asn Ile 
    1265                 1270                 1275             


Arg Thr  Gly Val Arg Thr Ile  Thr Thr Gly Ser Pro  Ile Thr Tyr 
    1280                 1285                 1290             


Ser Thr  Tyr Gly Lys Phe Leu  Ala Asp Gly Gly Cys  Ser Gly Gly 
    1295                 1300                 1305             


Ala Tyr  Asp Ile Ile Ile Cys  Asp Glu Cys His Ser  Thr Asp Ala 
    1310                 1315                 1320             


Thr Ser  Ile Leu Gly Ile Gly  Thr Val Leu Asp Gln  Ala Glu Thr 
    1325                 1330                 1335             


Ala Gly  Ala Arg Leu Val Val  Leu Ala Thr Ala Thr  Pro Pro Gly 
    1340                 1345                 1350             


Ser Ile  Thr Val Pro His Pro  Asn Ile Glu Glu Val  Ala Leu Ser 
    1355                 1360                 1365             


Thr Thr  Gly Glu Ile Pro Phe  Tyr Gly Lys Ala Ile  Pro Leu Glu 
    1370                 1375                 1380             


Ala Ile  Lys Gly Gly Arg His  Leu Ile Phe Cys His  Ser Lys Lys 
    1385                 1390                 1395             


Lys Cys  Asp Glu Leu Ala Ala  Lys Leu Val Ala Leu  Gly Ile Asn 
    1400                 1405                 1410             


Ala Val  Ala Tyr Tyr Arg Gly  Leu Asp Val Ser Val  Ile Pro Thr 
    1415                 1420                 1425             


Ser Gly  Asp Val Val Val Val  Ala Thr Asp Ala Leu  Met Thr Gly 
    1430                 1435                 1440             


Tyr Thr  Gly Asp Phe Asp Ser  Val Ile Asp Cys Asn  Thr Cys Val 
    1445                 1450                 1455             


Thr Gln  Thr Val Asp Leu Ser  Leu Asp Pro Thr Phe  Thr Ile Glu 
    1460                 1465                 1470             


Thr Thr  Thr Leu Pro Gln Asp  Ala Val Ser Arg Thr  Gln Arg Arg 
    1475                 1480                 1485             


Gly Arg  Thr Gly Arg Gly Lys  Pro Gly Ile Tyr Arg  Phe Val Ala 
    1490                 1495                 1500             


Leu Gly  Glu Arg Pro Ser Gly  Met Phe Asp Ser Ser  Val Leu Cys 
    1505                 1510                 1515             


Glu Cys  Tyr Asp Ala Gly Cys  Ala Trp Tyr Glu Leu  Thr Pro Ala 
    1520                 1525                 1530             


Glu Thr  Thr Val Arg Leu Arg  Ala Tyr Met Asn Thr  Pro Gly Leu 
    1535                 1540                 1545             


Pro Val  Cys Gln Asp His Leu  Glu Phe Trp Glu Gly  Val Phe Thr 
    1550                 1555                 1560             


Gly Leu  Thr His Ile Asp Ala  His Phe Leu Ser Gln  Thr Lys Gln 
    1565                 1570                 1575             


Ser Gly  Glu Asn Phe Pro Tyr  Leu Val Ala Tyr Gln  Ala Thr Val 
    1580                 1585                 1590             


Cys Ala  Arg Ala Gln Ala Pro  Pro Pro Ser Trp Asp  Gln Met Trp 
    1595                 1600                 1605             


Lys Cys  Leu Thr Arg Leu Lys  Pro Thr Leu His Gly  Pro Thr Pro 
    1610                 1615                 1620             


Leu Leu  Tyr Arg Leu Gly Ala  Val Gln Asn Glu Val  Thr Leu Thr 
    1625                 1630                 1635             


His Pro  Ile Thr Lys Tyr Ile  Met Thr Cys Met Ser  Ala Asp Leu 
    1640                 1645                 1650             


Glu Val  Val Thr Ser Thr Trp  Val Leu Val Gly Gly  Val Leu Ala 
    1655                 1660                 1665             


Ala Leu  Ala Ser Tyr Cys Leu  Ser Thr Gly Cys Val  Val Ile Val 
    1670                 1675                 1680             


Gly Arg  Ile Val Leu Ser Gly  Lys Pro Ala Ile Ile  Pro Asp Arg 
    1685                 1690                 1695             


Glu Val  Leu Tyr Arg Glu Phe  Asp Glu Met Glu Glu  Cys Ser Gln 
    1700                 1705                 1710             


His Leu  Pro Tyr Ile Glu Gln  Gly Met Met Leu Ala  Glu Gln Phe 
    1715                 1720                 1725             


Lys Gln  Lys Ala Leu Gly Leu  Leu Gln Thr Ala Ser  Arg Gln Ala 
    1730                 1735                 1740             


Glu Val  Val Ala Pro Ala Val  Gln Thr Asn Trp Gln  Lys Leu Glu 
    1745                 1750                 1755             


Ala Phe  Trp Ala Lys His Met  Trp Asn Phe Ile Ser  Gly Ile Gln 
    1760                 1765                 1770             


Tyr Leu  Ala Gly Leu Ser Thr  Leu Pro Gly Asn Pro  Ala Ile Ala 
    1775                 1780                 1785             


Ser Leu  Met Ala Phe Thr Ala  Ala Val Thr Ser Pro  Leu Thr Thr 
    1790                 1795                 1800             


Ser Gln  Thr Leu Leu Phe Asn  Ile Leu Gly Gly Trp  Val Ala Ala 
    1805                 1810                 1815             


Gln Leu  Ala Ala Pro Gly Ala  Ala Thr Ala Phe Val  Gly Ala Gly 
    1820                 1825                 1830             


Leu Ala  Gly Ala Ala Ile Gly  Ser Val Gly Leu Gly  Lys Val Leu 
    1835                 1840                 1845             


Val Asp  Ile Leu Ala Gly Tyr  Gly Ala Gly Val Ala  Gly Ala Leu 
    1850                 1855                 1860             


Val Ala  Phe Lys Ile Met Ser  Gly Glu Val Pro Ser  Thr Glu Asp 
    1865                 1870                 1875             


Leu Val  Asn Leu Leu Pro Ala  Ile Leu Ser Pro Gly  Ala Leu Val 
    1880                 1885                 1890             


Val Gly  Val Val Cys Ala Ala  Ile Leu Arg Arg His  Val Gly Pro 
    1895                 1900                 1905             


Gly Glu  Gly Ala Val Gln Trp  Met Asn Arg Leu Ile  Ala Phe Ala 
    1910                 1915                 1920             


Ser Arg  Gly Ser His Val Ser  Pro Thr His Tyr Val  Pro Glu Ser 
    1925                 1930                 1935             


Asp Ala  Ala Ala Arg Val Thr  Thr Ile Leu Ser Ser  Leu Thr Val 
    1940                 1945                 1950             


Thr Gln  Leu Leu Arg Arg Leu  His Gln Trp Ile Ser  Ser Glu Cys 
    1955                 1960                 1965             


Thr Thr  Pro Cys Ser Gly Ser  Trp Leu Arg Asp Ile  Trp Asp Trp 
    1970                 1975                 1980             


Ile Cys  Glu Val Leu Ser Asp  Phe Lys Thr Trp Leu  Lys Ala Lys 
    1985                 1990                 1995             


Leu Met  Pro Gln Leu Pro Gly  Ile Pro Phe Val Ser  Cys Gln Arg 
    2000                 2005                 2010             


Gly Tyr  Lys Gly Val Trp Arg  Gly Asp Gly Ile Met  His Thr Arg 
    2015                 2020                 2025             


Cys His  Cys Gly Ala Glu Ile  Thr Gly His Val Lys  Asn Gly Thr 
    2030                 2035                 2040             


Met Arg  Ile Val Gly Pro Lys  Thr Cys Arg Asn Met  Trp Ser Gly 
    2045                 2050                 2055             


Thr Phe  Pro Ile Asn Ala Tyr  Thr Thr Gly Pro Cys  Thr Pro Leu 
    2060                 2065                 2070             


Pro Ala  Pro Asn Tyr Thr Phe  Ala Leu Trp Arg Val  Ser Ala Glu 
    2075                 2080                 2085             


Glu Tyr  Val Glu Ile Arg Gln  Val Gly Asp Phe His  Tyr Val Thr 
    2090                 2095                 2100             


Gly Met  Thr Thr Asp Asn Leu  Lys Cys Pro Cys Gln  Val Pro Ser 
    2105                 2110                 2115             


Pro Glu  Phe Phe Thr Glu Leu  Asp Gly Val Arg Leu  His Arg Phe 
    2120                 2125                 2130             


Ala Pro  Pro Cys Lys Pro Leu  Leu Arg Glu Glu Val  Ser Phe Arg 
    2135                 2140                 2145             


Val Gly  Leu His Glu Tyr Pro  Val Gly Ser Gln Leu  Pro Cys Glu 
    2150                 2155                 2160             


Pro Glu  Pro Asp Val Ala Val  Leu Thr Ser Met Leu  Thr Asp Pro 
    2165                 2170                 2175             


Ser His  Ile Thr Ala Glu Ala  Ala Gly Arg Arg Leu  Ala Arg Gly 
    2180                 2185                 2190             


Ser Pro  Pro Ser Met Ala Ser  Ser Ser Ala Ser Gln  Leu Ser Ala 
    2195                 2200                 2205             


Pro Ser  Leu Arg Ala Thr Cys  Thr Thr Asn His Asp  Ser Pro Asp 
    2210                 2215                 2220             


Ala Glu  Leu Ile Glu Ala Asn  Leu Leu Trp Arg Gln  Glu Met Gly 
    2225                 2230                 2235             


Gly Asn  Ile Thr Arg Val Glu  Ser Glu Asn Lys Val  Val Ile Leu 
    2240                 2245                 2250             


Asp Ser  Phe Asp Pro Leu Val  Ala Glu Glu Asp Glu  Arg Glu Val 
    2255                 2260                 2265             


Ser Val  Pro Ala Glu Ile Leu  Arg Lys Ser Arg Lys  Phe Thr Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ile Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Pro  Trp Lys Lys Pro Asp  Tyr Glu Pro Pro Val  Val His Gly 
    2300                 2305                 2310             


Cys Pro  Leu Pro Pro Pro Gln  Ser Pro Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Lys Lys  Arg Thr Val Ile Leu  Thr Glu Ser Thr Leu  Pro Thr Ala 
    2330                 2335                 2340             


Leu Ala  Glu Leu Ala Thr Lys  Ser Phe Gly Ser Ser  Ser Thr Ser 
    2345                 2350                 2355             


Gly Ile  Thr Gly Asp Asp Thr  Thr Thr Ser Pro Glu  Pro Ala Ser 
    2360                 2365                 2370             


Ser Ser  Cys Pro Pro Asp Ser  Asp Ala Glu Ser Tyr  Ser Ser Met 
    2375                 2380                 2385             


Pro Pro  Leu Glu Gly Glu Pro  Gly Asp Pro Asp Leu  Ser Asp Gly 
    2390                 2395                 2400             


Ser Trp  Ser Thr Val Ser Ser  Glu Ala Asp Lys Glu  Asp Val Val 
    2405                 2410                 2415             


Cys Cys  Ser Met Ser Tyr Thr  Trp Thr Gly Ala Leu  Val Thr Pro 
    2420                 2425                 2430             


Cys Ala  Ala Glu Glu Gln Lys  Leu Pro Ile Asn Ala  Leu Ser Asn 
    2435                 2440                 2445             


Ser Leu  Leu Arg His His Asn  Leu Val Tyr Ser Thr  Thr Ser Arg 
    2450                 2455                 2460             


Ser Ala  Cys Gln Arg Gln Lys  Lys Val Thr Phe Asp  Arg Leu Gln 
    2465                 2470                 2475             


Val Leu  Asp Ser His Tyr Gln  Asp Val Leu Lys Glu  Val Lys Ala 
    2480                 2485                 2490             


Ala Ala  Ser Lys Val Lys Ala  Asn Leu Leu Ser Val  Glu Glu Ala 
    2495                 2500                 2505             


Cys Ser  Leu Thr Pro Pro His  Ser Ala Lys Ser Lys  Phe Gly Tyr 
    2510                 2515                 2520             


Gly Ala  Lys Asp Val Arg Cys  His Ala Arg Lys Ala  Val Asn His 
    2525                 2530                 2535             


Ile Asn  Ser Val Trp Lys Asp  Leu Leu Glu Asp Ser  Val Thr Pro 
    2540                 2545                 2550             


Ile Asp  Thr Thr Ile Met Ala  Lys Asn Glu Val Phe  Cys Val Gln 
    2555                 2560                 2565             


Pro Glu  Lys Gly Gly Arg Lys  Pro Ala Arg Leu Ile  Val Phe Pro 
    2570                 2575                 2580             


Asp Leu  Gly Val Arg Val Cys  Glu Lys Met Ala Leu  Tyr Asp Val 
    2585                 2590                 2595             


Val Ser  Lys Leu Pro Leu Ala  Val Met Gly Ser Ser  Tyr Gly Phe 
    2600                 2605                 2610             


Gln Tyr  Ser Pro Gly Gln Arg  Val Glu Phe Leu Val  Gln Ala Trp 
    2615                 2620                 2625             


Lys Ser  Lys Lys Thr Pro Met  Gly Phe Ser Tyr Asp  Thr Arg Cys 
    2630                 2635                 2640             


Phe Asp  Ser Thr Val Thr Glu  Asn Asp Ile Arg Thr  Glu Glu Ala 
    2645                 2650                 2655             


Ile Tyr  Gln Cys Cys Asp Leu  Asp Pro Gln Ala Arg  Val Ala Ile 
    2660                 2665                 2670             


Lys Ser  Leu Thr Glu Arg Leu  Tyr Val Gly Gly Pro  Leu Thr Asn 
    2675                 2680                 2685             


Ser Arg  Gly Glu Asn Cys Gly  Tyr Arg Arg Cys Arg  Ala Ser Gly 
    2690                 2695                 2700             


Val Leu  Thr Thr Ser Cys Gly  Asn Thr Leu Thr Cys  Tyr Ile Lys 
    2705                 2710                 2715             


Ala Arg  Ala Ala Cys Arg Ala  Ala Gly Leu Gln Asp  Cys Thr Met 
    2720                 2725                 2730             


Leu Val  Cys Gly Asp Asp Leu  Val Val Ile Cys Glu  Ser Ala Gly 
    2735                 2740                 2745             


Val Gln  Glu Asp Ala Ala Ser  Leu Arg Ala Phe Thr  Glu Ala Met 
    2750                 2755                 2760             


Thr Arg  Tyr Ser Ala Pro Pro  Gly Asp Pro Pro Gln  Pro Glu Tyr 
    2765                 2770                 2775             


Asp Leu  Glu Leu Ile Thr Ser  Cys Ser Ser Asn Val  Ser Val Ala 
    2780                 2785                 2790             


His Asp  Gly Ala Gly Lys Arg  Val Tyr Tyr Leu Thr  Arg Asp Pro 
    2795                 2800                 2805             


Thr Thr  Pro Leu Ala Arg Ala  Ala Trp Glu Thr Ala  Arg His Thr 
    2810                 2815                 2820             


Pro Val  Asn Ser Trp Leu Gly  Asn Ile Ile Met Phe  Ala Pro Thr 
    2825                 2830                 2835             


Leu Trp  Ala Arg Met Ile Leu  Met Thr His Phe Phe  Ser Val Leu 
    2840                 2845                 2850             


Ile Ala  Arg Asp Gln Leu Glu  Gln Ala Leu Asp Cys  Glu Ile Tyr 
    2855                 2860                 2865             


Gly Ala  Cys Tyr Ser Ile Glu  Pro Leu Asp Leu Pro  Pro Ile Ile 
    2870                 2875                 2880             


Gln Arg  Leu His Gly Leu Ser  Ala Phe Ser Leu His  Ser Tyr Ser 
    2885                 2890                 2895             


Pro Gly  Glu Ile Asn Arg Val  Ala Ala Cys Leu Arg  Lys Leu Gly 
    2900                 2905                 2910             


Val Pro  Pro Leu Arg Ala Trp  Arg His Arg Ala Arg  Asn Val Arg 
    2915                 2920                 2925             


Ala Arg  Leu Leu Ser Arg Gly  Gly Arg Ala Ala Ile  Cys Gly Lys 
    2930                 2935                 2940             


Tyr Leu  Phe Asn Trp Ala Val  Arg Thr Lys Leu Lys  Leu Thr Pro 
    2945                 2950                 2955             


Ile Ala  Ala Ala Gly Arg Leu  Asp Leu Ser Gly Trp  Phe Thr Ala 
    2960                 2965                 2970             


Gly Tyr  Ser Gly Gly Gly Ile  Phe His Ser Val Ser  His Ala Arg 
    2975                 2980                 2985             


Pro Arg  Trp Phe Trp Ser Cys  Leu Leu Leu Leu Ala  Ala Gly Val 
    2990                 2995                 3000             


Gly Ile  Tyr Leu Leu Pro Asn  Arg 
    3005                 3010     


<210>  156
<211>  3011
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  plasmid

<400>  156

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Gly Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Thr Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Phe Glu Ala Ala Asp Ala Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Val Thr Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Thr Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Ser Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Ala Leu Leu Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Met Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr Tyr Val Thr Gly Gly Ser Ala Ala Arg Thr Thr Ala Gly Leu Ala 
385                 390                 395                 400 


Ser Leu Phe Ser Pro Gly Ala Lys Gln Asn Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Asn Thr Gly Trp Ile Ala Gly Leu Phe Tyr His His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Ser Glu Arg Leu Ala Ser Cys Arg Pro Leu Thr Asp 
    450                 455                 460                 


Phe Ala Gln Gly Trp Gly Pro Ile Ser His Ala Asp Gly Ser Gly Pro 
465                 470                 475                 480 


Asp Gln Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Lys Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly Ala Pro Thr Tyr Ser 
        515                 520                 525             


Trp Gly Ala Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu Arg Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Ile Asn Tyr 
    610                 615                 620                 


Thr Val Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Glu Ala Ala Cys Asn Trp Thr Arg Gly Asp Arg Cys Asn Leu Asp Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Ile Ala Ser Trp Ala Ile Lys Trp Glu Tyr Val Val 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Val Glu Ala Ala Leu Glu Asn Leu Val 
            740                 745                 750         


Val Leu Asn Ala Ala Ser Leu Ala Gly Thr His Gly Leu Val Ser Phe 
        755                 760                 765             


Leu Val Phe Phe Cys Phe Ala Trp Tyr Leu Lys Gly Lys Trp Val Pro 
    770                 775                 780                 


Gly Ala Val Tyr Ala Leu Tyr Gly Met Trp Pro Leu Leu Leu Leu Leu 
785                 790                 795                 800 


Leu Ala Leu Pro Gln Arg Ala Tyr Ala Leu Asp Thr Glu Val Ala Ala 
                805                 810                 815     


Ser Cys Gly Gly Val Val Leu Val Gly Leu Met Ala Leu Thr Leu Ser 
            820                 825                 830         


Pro Tyr Tyr Lys Arg Tyr Ile Ser Trp Cys Leu Trp Trp Leu Gln Tyr 
        835                 840                 845             


Phe Leu Thr Arg Ile Glu Ala Gln Leu His Val Trp Ile Pro Pro Leu 
    850                 855                 860                 


Asn Val Arg Gly Gly Arg Asp Ala Val Ile Leu Leu Met Cys Val Val 
865                 870                 875                 880 


His Pro Ala Leu Val Phe Asp Ile Thr Lys Leu Leu Leu Ala Ala Phe 
                885                 890                 895     


Gly Pro Leu Trp Ile Leu Gln Ala Ser Leu Leu Lys Val Pro Tyr Phe 
            900                 905                 910         


Val Arg Val Gln Gly Leu Leu Arg Ile Cys Ala Leu Ala Arg Lys Met 
        915                 920                 925             


Ala Gly Gly His Tyr Val Gln Met Ala Ile Ile Lys Leu Gly Ala Leu 
    930                 935                 940                 


Thr Gly Thr Tyr Val Tyr Asn His Leu Thr Pro Leu Arg Asp Trp Ala 
945                 950                 955                 960 


His Asn Gly Leu Arg Asp Leu Ala Val Ala Val Glu Pro Val Val Phe 
                965                 970                 975     


Ser Arg Met Glu Thr Lys Leu Ile Thr Trp Gly Ala Asp Thr Ala Ala 
            980                 985                 990         


Cys Gly Asp Ile Ile Asn Gly Leu  Pro Val Ser Ala Arg  Arg Gly Arg 
        995                 1000                 1005             


Glu Ile  Leu Leu Gly Pro Ala  Asp Gly Met Val Ser  Lys Gly Trp 
    1010                 1015                 1020             


Arg Leu  Leu Ala Pro Ile Thr  Ala Tyr Ala Gln Gln  Thr Arg Gly 
    1025                 1030                 1035             


Leu Leu  Gly Cys Ile Ile Thr  Ser Leu Thr Gly Arg  Asp Lys Asn 
    1040                 1045                 1050             


Gln Val  Glu Gly Glu Ile Gln  Ile Val Ser Thr Ala  Ala Gln Thr 
    1055                 1060                 1065             


Phe Leu  Ala Thr Cys Ile Asn  Gly Val Cys Trp Thr  Val Tyr His 
    1070                 1075                 1080             


Gly Ala  Gly Thr Arg Thr Ile  Ala Ser Pro Lys Gly  Pro Val Ile 
    1085                 1090                 1095             


Gln Met  Tyr Thr Asn Val Asp  Lys Asp Leu Val Gly  Trp Pro Ala 
    1100                 1105                 1110             


Pro Gln  Gly Ala Arg Ser Leu  Thr Pro Cys Thr Cys  Gly Ser Ser 
    1115                 1120                 1125             


Asp Leu  Tyr Leu Val Thr Arg  His Ala Asp Val Ile  Pro Val Arg 
    1130                 1135                 1140             


Arg Arg  Gly Asp Ser Arg Gly  Ser Leu Leu Ser Pro  Arg Pro Ile 
    1145                 1150                 1155             


Ser Tyr  Leu Lys Gly Ser Ser  Gly Gly Pro Leu Leu  Cys Pro Ala 
    1160                 1165                 1170             


Gly His  Ala Val Gly Leu Phe  Arg Ala Ala Val Cys  Thr Arg Gly 
    1175                 1180                 1185             


Val Ala  Lys Ala Val Asp Phe  Ile Pro Val Glu Asn  Leu Glu Thr 
    1190                 1195                 1200             


Thr Met  Arg Ser Pro Val Phe  Thr Asp Asn Ser Ser  Pro Pro Ala 
    1205                 1210                 1215             


Val Pro  Gln Ser Phe Gln Val  Gly His Leu His Ala  Pro Thr Gly 
    1220                 1225                 1230             


Ser Gly  Lys Ser Thr Lys Val  Pro Ala Ala Tyr Ala  Ala Gln Gly 
    1235                 1240                 1245             


Tyr Lys  Val Leu Val Leu Asn  Pro Ser Val Ala Ala  Thr Leu Gly 
    1250                 1255                 1260             


Phe Gly  Ala Tyr Met Ser Lys  Ala His Gly Val Asp  Pro Asn Ile 
    1265                 1270                 1275             


Arg Thr  Gly Val Arg Thr Ile  Thr Thr Gly Ser Pro  Ile Thr Tyr 
    1280                 1285                 1290             


Ser Thr  Tyr Gly Lys Phe Leu  Ala Asp Gly Gly Cys  Ser Gly Gly 
    1295                 1300                 1305             


Ala Tyr  Asp Ile Ile Ile Cys  Asp Glu Cys His Ser  Thr Asp Ala 
    1310                 1315                 1320             


Thr Ser  Ile Leu Gly Ile Gly  Thr Val Leu Asp Gln  Ala Glu Thr 
    1325                 1330                 1335             


Ala Gly  Ala Arg Leu Val Val  Leu Ala Thr Ala Thr  Pro Pro Gly 
    1340                 1345                 1350             


Ser Ile  Thr Val Pro His Pro  Asn Ile Glu Glu Val  Ala Leu Ser 
    1355                 1360                 1365             


Thr Thr  Gly Glu Ile Pro Phe  Tyr Gly Lys Ala Ile  Pro Leu Glu 
    1370                 1375                 1380             


Ala Ile  Lys Gly Gly Arg His  Leu Ile Phe Cys His  Ser Lys Lys 
    1385                 1390                 1395             


Lys Cys  Asp Glu Leu Ala Ala  Lys Leu Val Ala Leu  Gly Ile Asn 
    1400                 1405                 1410             


Ala Val  Ala Tyr Tyr Arg Gly  Leu Asp Val Ser Val  Ile Pro Thr 
    1415                 1420                 1425             


Ser Gly  Asp Val Val Val Val  Ala Thr Asp Ala Leu  Met Thr Gly 
    1430                 1435                 1440             


Tyr Thr  Gly Asp Phe Asp Ser  Val Ile Asp Cys Asn  Thr Cys Val 
    1445                 1450                 1455             


Thr Gln  Thr Val Asp Leu Ser  Leu Asp Pro Thr Phe  Thr Ile Glu 
    1460                 1465                 1470             


Thr Thr  Thr Leu Pro Gln Asp  Ala Val Ser Arg Thr  Gln Arg Arg 
    1475                 1480                 1485             


Gly Arg  Thr Gly Arg Gly Lys  Pro Gly Ile Tyr Arg  Phe Val Ala 
    1490                 1495                 1500             


Leu Gly  Glu Arg Pro Ser Gly  Met Phe Asp Ser Ser  Val Leu Cys 
    1505                 1510                 1515             


Glu Cys  Tyr Asp Ala Gly Cys  Ala Trp Tyr Glu Leu  Thr Pro Ala 
    1520                 1525                 1530             


Glu Thr  Thr Val Arg Leu Arg  Ala Tyr Met Asn Thr  Pro Gly Leu 
    1535                 1540                 1545             


Pro Val  Cys Gln Asp His Leu  Glu Phe Trp Glu Gly  Val Phe Thr 
    1550                 1555                 1560             


Gly Leu  Thr His Ile Asp Ala  His Phe Leu Ser Gln  Thr Lys Gln 
    1565                 1570                 1575             


Ser Gly  Glu Asn Phe Pro Tyr  Leu Val Ala Tyr Gln  Ala Thr Val 
    1580                 1585                 1590             


Cys Ala  Arg Ala Gln Ala Pro  Pro Pro Ser Trp Asp  Gln Met Trp 
    1595                 1600                 1605             


Lys Cys  Leu Thr Arg Leu Lys  Pro Thr Leu His Gly  Pro Thr Pro 
    1610                 1615                 1620             


Leu Leu  Tyr Arg Leu Gly Ala  Val Gln Asn Glu Val  Thr Leu Thr 
    1625                 1630                 1635             


His Pro  Ile Thr Lys Tyr Ile  Met Thr Cys Met Ser  Ala Asp Leu 
    1640                 1645                 1650             


Glu Val  Val Thr Ser Thr Trp  Val Leu Val Gly Gly  Val Leu Ala 
    1655                 1660                 1665             


Ala Leu  Ala Ser Tyr Cys Leu  Ser Thr Gly Cys Val  Val Ile Val 
    1670                 1675                 1680             


Gly Arg  Ile Val Leu Ser Gly  Lys Pro Ala Ile Ile  Pro Asp Arg 
    1685                 1690                 1695             


Glu Val  Leu Tyr Arg Glu Phe  Asp Glu Met Glu Glu  Cys Ser Gln 
    1700                 1705                 1710             


His Leu  Pro Tyr Ile Glu Gln  Gly Met Met Leu Ala  Glu Gln Phe 
    1715                 1720                 1725             


Lys Gln  Lys Ala Leu Gly Leu  Leu Gln Thr Ala Ser  Arg Gln Ala 
    1730                 1735                 1740             


Glu Val  Val Ala Pro Ala Val  Gln Thr Asn Trp Gln  Lys Leu Glu 
    1745                 1750                 1755             


Ala Phe  Trp Ala Lys His Met  Trp Asn Phe Ile Ser  Gly Ile Gln 
    1760                 1765                 1770             


Tyr Leu  Ala Gly Leu Ser Thr  Leu Pro Gly Asn Pro  Ala Ile Ala 
    1775                 1780                 1785             


Ser Leu  Met Ala Phe Thr Ala  Ala Val Thr Ser Pro  Leu Thr Thr 
    1790                 1795                 1800             


Ser Gln  Thr Leu Leu Phe Asn  Ile Leu Gly Gly Trp  Val Ala Ala 
    1805                 1810                 1815             


Gln Leu  Ala Ala Pro Gly Ala  Ala Thr Ala Phe Val  Gly Ala Gly 
    1820                 1825                 1830             


Leu Ala  Gly Ala Ala Ile Gly  Ser Val Gly Leu Gly  Lys Val Leu 
    1835                 1840                 1845             


Val Asp  Ile Leu Ala Gly Tyr  Gly Ala Gly Val Ala  Gly Ala Leu 
    1850                 1855                 1860             


Val Ala  Phe Lys Ile Met Ser  Gly Glu Val Pro Ser  Thr Glu Asp 
    1865                 1870                 1875             


Leu Val  Asn Leu Leu Pro Ala  Ile Leu Ser Pro Gly  Ala Leu Val 
    1880                 1885                 1890             


Val Gly  Val Val Cys Ala Ala  Ile Leu Arg Arg His  Val Gly Pro 
    1895                 1900                 1905             


Gly Glu  Gly Ala Val Gln Trp  Met Asn Arg Leu Ile  Ala Phe Ala 
    1910                 1915                 1920             


Ser Arg  Gly Thr His Val Ser  Pro Thr His Tyr Val  Pro Glu Ser 
    1925                 1930                 1935             


Asp Ala  Ala Ala Arg Val Thr  Thr Ile Leu Ser Ser  Leu Thr Val 
    1940                 1945                 1950             


Thr Gln  Leu Leu Arg Arg Leu  His Gln Trp Ile Ser  Ser Glu Cys 
    1955                 1960                 1965             


Thr Thr  Pro Cys Ser Gly Ser  Trp Leu Arg Asp Ile  Trp Asp Trp 
    1970                 1975                 1980             


Ile Cys  Glu Val Leu Ser Asp  Phe Lys Thr Trp Leu  Lys Ala Lys 
    1985                 1990                 1995             


Leu Met  Pro Gln Leu Pro Gly  Ile Pro Phe Val Ser  Cys Gln Arg 
    2000                 2005                 2010             


Gly Tyr  Lys Gly Val Trp Arg  Gly Asp Gly Ile Met  His Thr Arg 
    2015                 2020                 2025             


Cys His  Cys Gly Ala Glu Ile  Thr Gly His Val Lys  Asn Gly Thr 
    2030                 2035                 2040             


Met Arg  Ile Val Gly Pro Lys  Thr Cys Arg Asn Met  Trp Ser Gly 
    2045                 2050                 2055             


Thr Phe  Pro Ile Asn Ala Tyr  Thr Thr Gly Pro Cys  Thr Pro Leu 
    2060                 2065                 2070             


Pro Ala  Pro Asn Tyr Thr Phe  Ala Leu Trp Arg Val  Ser Ala Glu 
    2075                 2080                 2085             


Glu Tyr  Val Glu Ile Arg Gln  Val Gly Asp Phe His  Tyr Val Thr 
    2090                 2095                 2100             


Gly Met  Thr Thr Asp Asn Leu  Lys Cys Pro Cys Gln  Val Pro Ser 
    2105                 2110                 2115             


Pro Glu  Phe Phe Thr Glu Leu  Asp Gly Val Arg Leu  His Arg Phe 
    2120                 2125                 2130             


Ala Pro  Pro Cys Lys Pro Leu  Leu Arg Glu Glu Val  Ser Phe Arg 
    2135                 2140                 2145             


Val Gly  Leu His Glu Tyr Pro  Val Gly Ser Gln Leu  Pro Cys Glu 
    2150                 2155                 2160             


Pro Glu  Pro Asp Val Ala Val  Leu Thr Ser Met Leu  Thr Asp Pro 
    2165                 2170                 2175             


Ser His  Ile Thr Ala Glu Ala  Ala Gly Arg Arg Leu  Ala Arg Gly 
    2180                 2185                 2190             


Ser Pro  Pro Ser Met Ala Ser  Ser Ser Ala Ser Gln  Leu Ser Ala 
    2195                 2200                 2205             


Pro Ser  Leu Arg Ala Thr Cys  Thr Thr Asn His Asp  Ser Pro Asp 
    2210                 2215                 2220             


Ala Glu  Leu Ile Glu Ala Asn  Leu Leu Trp Arg Gln  Glu Met Gly 
    2225                 2230                 2235             


Gly Asn  Ile Thr Arg Val Glu  Ser Glu Asn Lys Val  Val Ile Leu 
    2240                 2245                 2250             


Asp Ser  Phe Asp Pro Leu Val  Ala Glu Glu Asp Glu  Arg Glu Val 
    2255                 2260                 2265             


Ser Val  Pro Ala Glu Ile Leu  Arg Lys Ser Arg Lys  Phe Thr Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ile Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Pro  Trp Lys Lys Pro Asp  Tyr Glu Pro Pro Val  Val His Gly 
    2300                 2305                 2310             


Cys Pro  Leu Pro Pro Pro Gln  Ser Pro Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Lys Lys  Arg Thr Val Ile Leu  Thr Glu Ser Thr Leu  Pro Thr Ala 
    2330                 2335                 2340             


Leu Ala  Glu Leu Ala Thr Lys  Ser Phe Gly Ser Ser  Ser Thr Ser 
    2345                 2350                 2355             


Gly Ile  Thr Gly Asp Asp Thr  Thr Thr Ser Pro Glu  Pro Ala Ser 
    2360                 2365                 2370             


Ser Ser  Cys Pro Pro Asp Ser  Asp Ala Glu Ser Tyr  Ser Ser Met 
    2375                 2380                 2385             


Pro Pro  Leu Glu Gly Glu Pro  Gly Asp Pro Asp Leu  Ser Asp Gly 
    2390                 2395                 2400             


Ser Trp  Ser Thr Val Ser Ser  Glu Ala Asp Lys Glu  Asp Val Val 
    2405                 2410                 2415             


Cys Cys  Ser Met Ser Tyr Thr  Trp Thr Gly Ala Leu  Val Thr Pro 
    2420                 2425                 2430             


Cys Ala  Ala Glu Glu Gln Lys  Leu Pro Ile Asn Ala  Leu Ser Asn 
    2435                 2440                 2445             


Ser Leu  Leu Arg His His Asn  Leu Val Tyr Ser Thr  Thr Ser Arg 
    2450                 2455                 2460             


Ser Ala  Cys Gln Arg Gln Lys  Lys Val Thr Phe Asp  Arg Leu Gln 
    2465                 2470                 2475             


Val Leu  Asp Ser His Tyr Gln  Asp Val Leu Lys Glu  Val Lys Ala 
    2480                 2485                 2490             


Ala Ala  Ser Lys Val Lys Ala  Asn Leu Leu Ser Val  Glu Glu Ala 
    2495                 2500                 2505             


Cys Ser  Leu Thr Pro Pro His  Ser Ala Lys Ser Lys  Phe Gly Tyr 
    2510                 2515                 2520             


Gly Ala  Lys Asp Val Arg Cys  His Ala Arg Lys Ala  Val Asn His 
    2525                 2530                 2535             


Ile Asn  Ser Val Trp Lys Asp  Leu Leu Glu Asp Ser  Val Thr Pro 
    2540                 2545                 2550             


Ile Asp  Thr Thr Ile Met Ala  Lys Asn Glu Val Phe  Cys Val Gln 
    2555                 2560                 2565             


Pro Glu  Lys Gly Gly Arg Lys  Pro Ala Arg Leu Ile  Val Phe Pro 
    2570                 2575                 2580             


Asp Leu  Gly Val Arg Val Cys  Glu Lys Met Ala Leu  Tyr Asp Val 
    2585                 2590                 2595             


Val Ser  Lys Leu Pro Leu Ala  Val Met Gly Ser Ser  Tyr Gly Phe 
    2600                 2605                 2610             


Gln Tyr  Ser Pro Gly Gln Arg  Val Glu Phe Leu Val  Gln Ala Trp 
    2615                 2620                 2625             


Lys Ser  Lys Lys Thr Pro Met  Gly Phe Ser Tyr Asp  Thr Arg Cys 
    2630                 2635                 2640             


Phe Asp  Ser Thr Val Thr Glu  Asn Asp Ile Arg Thr  Glu Glu Ala 
    2645                 2650                 2655             


Ile Tyr  Gln Cys Cys Asp Leu  Asp Pro Gln Ala Arg  Val Ala Ile 
    2660                 2665                 2670             


Lys Ser  Leu Thr Glu Arg Leu  Tyr Val Gly Gly Pro  Leu Thr Asn 
    2675                 2680                 2685             


Ser Arg  Gly Glu Asn Cys Gly  Tyr Arg Arg Cys Arg  Ala Ser Gly 
    2690                 2695                 2700             


Val Leu  Thr Thr Ser Cys Gly  Asn Thr Leu Thr Cys  Tyr Ile Lys 
    2705                 2710                 2715             


Ala Arg  Ala Ala Cys Arg Ala  Ala Gly Leu Gln Asp  Cys Thr Met 
    2720                 2725                 2730             


Leu Val  Cys Gly Asp Asp Leu  Val Val Ile Cys Glu  Ser Ala Gly 
    2735                 2740                 2745             


Val Gln  Glu Asp Ala Ala Ser  Leu Arg Ala Phe Thr  Glu Ala Met 
    2750                 2755                 2760             


Thr Arg  Tyr Ser Ala Pro Pro  Gly Asp Pro Pro Gln  Pro Glu Tyr 
    2765                 2770                 2775             


Asp Leu  Glu Leu Ile Thr Ser  Cys Ser Ser Asn Val  Ser Val Ala 
    2780                 2785                 2790             


His Asp  Gly Ala Gly Lys Arg  Val Tyr Tyr Leu Thr  Arg Asp Pro 
    2795                 2800                 2805             


Thr Thr  Pro Leu Ala Arg Ala  Ala Trp Glu Thr Ala  Arg His Thr 
    2810                 2815                 2820             


Pro Val  Asn Ser Trp Leu Gly  Asn Ile Ile Met Phe  Ala Pro Thr 
    2825                 2830                 2835             


Leu Trp  Ala Arg Met Ile Leu  Met Thr His Phe Phe  Ser Val Leu 
    2840                 2845                 2850             


Ile Ala  Arg Asp Gln Leu Glu  Gln Ala Leu Asp Cys  Glu Ile Tyr 
    2855                 2860                 2865             


Gly Ala  Cys Tyr Ser Ile Glu  Pro Leu Asp Leu Pro  Pro Ile Ile 
    2870                 2875                 2880             


Gln Arg  Leu His Gly Leu Ser  Ala Phe Ser Leu His  Ser Tyr Ser 
    2885                 2890                 2895             


Pro Gly  Glu Ile Asn Arg Val  Ala Ala Cys Leu Arg  Lys Leu Gly 
    2900                 2905                 2910             


Val Pro  Pro Leu Arg Ala Trp  Arg His Arg Ala Arg  Asn Val Arg 
    2915                 2920                 2925             


Ala Arg  Leu Leu Ser Arg Gly  Gly Arg Ala Ala Ile  Cys Gly Lys 
    2930                 2935                 2940             


Tyr Leu  Phe Asn Trp Ala Val  Arg Thr Lys Leu Lys  Leu Thr Pro 
    2945                 2950                 2955             


Ile Ala  Ala Ala Gly Arg Leu  Asp Leu Ser Gly Trp  Phe Thr Ala 
    2960                 2965                 2970             


Gly Tyr  Ser Gly Gly Gly Ile  Phe His Ser Val Ser  His Ala Arg 
    2975                 2980                 2985             


Pro Arg  Trp Phe Trp Ser Cys  Leu Leu Leu Leu Ala  Ala Gly Val 
    2990                 2995                 3000             


Gly Ile  Tyr Leu Leu Pro Asn  Arg 
    3005                 3010     


<210>  157
<211>  3011
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  plasmid

<400>  157

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Gly Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Thr Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Phe Glu Ala Ala Asp Ala Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Val Thr Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Thr Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Ser Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Ala Leu Leu Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Met Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr Tyr Val Thr Gly Gly Ser Ala Ala Arg Thr Thr Ala Gly Leu Ala 
385                 390                 395                 400 


Ser Leu Phe Ser Pro Gly Ala Lys Gln Asn Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Asn Thr Gly Trp Ile Ala Gly Leu Phe Tyr His His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Ser Glu Arg Leu Ala Ser Cys Arg Pro Leu Thr Asp 
    450                 455                 460                 


Phe Ala Gln Gly Trp Gly Pro Ile Ser His Ala Asp Gly Ser Gly Pro 
465                 470                 475                 480 


Asp Gln Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Lys Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly Ala Pro Thr Tyr Ser 
        515                 520                 525             


Trp Gly Ala Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu Arg Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Ile Asn Tyr 
    610                 615                 620                 


Thr Val Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Glu Ala Ala Cys Asn Trp Thr Arg Gly Asp Arg Cys Asn Leu Asp Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Ile Ala Ser Trp Ala Ile Lys Trp Glu Tyr Val Val 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Val Glu Ala Ala Leu Glu Asn Leu Val 
            740                 745                 750         


Val Leu Asn Ala Ala Ser Leu Ala Gly Thr His Gly Leu Val Ser Phe 
        755                 760                 765             


Leu Val Phe Phe Cys Phe Ala Trp Tyr Leu Lys Gly Lys Trp Val Pro 
    770                 775                 780                 


Gly Ala Val Tyr Ala Leu Tyr Gly Met Trp Pro Leu Leu Leu Leu Leu 
785                 790                 795                 800 


Leu Ala Leu Pro Gln Arg Ala Tyr Ala Leu Asp Thr Glu Val Ala Ala 
                805                 810                 815     


Ser Cys Gly Gly Val Val Leu Val Gly Leu Met Ala Leu Thr Leu Ser 
            820                 825                 830         


Pro Tyr Tyr Lys Arg Tyr Ile Ser Trp Cys Leu Trp Trp Leu Gln Tyr 
        835                 840                 845             


Phe Leu Thr Arg Ile Glu Ala Gln Leu His Val Trp Ile Pro Pro Leu 
    850                 855                 860                 


Asn Val Arg Gly Gly Arg Asp Ala Val Ile Leu Leu Met Cys Val Val 
865                 870                 875                 880 


His Pro Ala Leu Val Phe Asp Ile Thr Lys Leu Leu Leu Ala Ala Phe 
                885                 890                 895     


Gly Pro Leu Trp Ile Leu Gln Ala Ser Leu Leu Lys Val Pro Tyr Phe 
            900                 905                 910         


Val Arg Val Gln Gly Leu Leu Arg Ile Cys Ala Leu Ala Arg Lys Met 
        915                 920                 925             


Ala Gly Gly His Tyr Val Gln Met Ala Ile Ile Lys Leu Gly Ala Leu 
    930                 935                 940                 


Thr Gly Thr Tyr Val Tyr Asn His Leu Thr Pro Leu Arg Asp Trp Ala 
945                 950                 955                 960 


His Asn Gly Leu Arg Asp Leu Ala Val Ala Val Glu Pro Val Val Phe 
                965                 970                 975     


Ser Arg Met Glu Thr Lys Leu Ile Thr Trp Gly Ala Asp Thr Ala Ala 
            980                 985                 990         


Cys Gly Asp Ile Ile Asn Gly Leu  Pro Val Ser Ala Arg  Arg Gly Arg 
        995                 1000                 1005             


Glu Ile  Leu Leu Gly Pro Ala  Asp Gly Met Val Ser  Lys Gly Trp 
    1010                 1015                 1020             


Arg Leu  Leu Ala Pro Ile Thr  Ala Tyr Ala Gln Gln  Thr Arg Gly 
    1025                 1030                 1035             


Leu Leu  Gly Cys Ile Ile Thr  Ser Leu Thr Gly Arg  Asp Lys Asn 
    1040                 1045                 1050             


Gln Val  Glu Gly Glu Ile Gln  Ile Val Ser Thr Ala  Ala Gln Thr 
    1055                 1060                 1065             


Phe Leu  Ala Thr Cys Ile Asn  Gly Val Cys Trp Thr  Val Tyr His 
    1070                 1075                 1080             


Gly Ala  Gly Thr Arg Thr Ile  Ala Ser Pro Lys Gly  Pro Val Ile 
    1085                 1090                 1095             


Gln Met  Tyr Thr Asn Val Asp  Lys Asp Leu Val Gly  Trp Pro Ala 
    1100                 1105                 1110             


Pro Gln  Gly Ala Arg Ser Leu  Thr Pro Cys Thr Cys  Gly Ser Ser 
    1115                 1120                 1125             


Asp Leu  Tyr Leu Val Thr Arg  His Ala Asp Val Ile  Pro Val Arg 
    1130                 1135                 1140             


Arg Arg  Gly Asp Ser Arg Gly  Ser Leu Leu Ser Pro  Arg Pro Ile 
    1145                 1150                 1155             


Ser Tyr  Leu Lys Gly Ser Ser  Gly Gly Pro Leu Leu  Cys Pro Ala 
    1160                 1165                 1170             


Gly His  Ala Val Gly Leu Phe  Arg Ala Ala Val Cys  Thr Arg Gly 
    1175                 1180                 1185             


Val Ala  Lys Ala Val Asp Phe  Ile Pro Val Glu Asn  Leu Glu Thr 
    1190                 1195                 1200             


Thr Met  Arg Ser Pro Val Phe  Thr Asp Asn Ser Ser  Pro Pro Ala 
    1205                 1210                 1215             


Val Pro  Gln Ser Phe Gln Val  Gly His Leu His Ala  Pro Thr Gly 
    1220                 1225                 1230             


Ser Gly  Lys Ser Thr Lys Val  Pro Ala Ala Tyr Ala  Ala Gln Gly 
    1235                 1240                 1245             


Tyr Lys  Val Leu Val Leu Asn  Pro Ser Val Ala Ala  Thr Leu Gly 
    1250                 1255                 1260             


Phe Gly  Ala Tyr Met Ser Lys  Ala His Gly Val Asp  Pro Asn Ile 
    1265                 1270                 1275             


Arg Thr  Gly Val Arg Thr Ile  Thr Thr Gly Ser Pro  Ile Thr Tyr 
    1280                 1285                 1290             


Ser Thr  Tyr Gly Lys Phe Leu  Ala Asp Gly Gly Cys  Ser Gly Gly 
    1295                 1300                 1305             


Ala Tyr  Asp Ile Ile Ile Cys  Asp Glu Cys His Ser  Thr Asp Ala 
    1310                 1315                 1320             


Thr Ser  Ile Leu Gly Ile Gly  Thr Val Leu Asp Gln  Ala Glu Thr 
    1325                 1330                 1335             


Ala Gly  Ala Arg Leu Val Val  Leu Ala Thr Ala Thr  Pro Pro Gly 
    1340                 1345                 1350             


Ser Ile  Thr Val Pro His Pro  Asn Ile Glu Glu Val  Ala Leu Ser 
    1355                 1360                 1365             


Thr Thr  Gly Glu Ile Pro Phe  Tyr Gly Lys Ala Ile  Pro Leu Glu 
    1370                 1375                 1380             


Ala Ile  Lys Gly Gly Arg His  Leu Ile Phe Cys His  Ser Lys Lys 
    1385                 1390                 1395             


Lys Cys  Asp Glu Leu Ala Ala  Lys Leu Val Ala Leu  Gly Ile Asn 
    1400                 1405                 1410             


Ala Val  Ala Tyr Tyr Arg Gly  Leu Asp Val Ser Val  Ile Pro Thr 
    1415                 1420                 1425             


Ser Gly  Asp Val Val Val Val  Ala Thr Asp Ala Leu  Met Thr Gly 
    1430                 1435                 1440             


Tyr Thr  Gly Asp Phe Asp Ser  Val Ile Asp Cys Asn  Thr Cys Val 
    1445                 1450                 1455             


Thr Gln  Thr Val Asp Leu Ser  Leu Asp Pro Thr Phe  Thr Ile Glu 
    1460                 1465                 1470             


Thr Thr  Thr Leu Pro Gln Asp  Ala Val Ser Arg Thr  Gln Arg Arg 
    1475                 1480                 1485             


Gly Arg  Thr Gly Arg Gly Lys  Pro Gly Ile Tyr Arg  Phe Val Ala 
    1490                 1495                 1500             


Leu Gly  Glu Arg Pro Ser Gly  Met Phe Asp Ser Ser  Val Leu Cys 
    1505                 1510                 1515             


Glu Cys  Tyr Asp Ala Gly Cys  Ala Trp Tyr Glu Leu  Thr Pro Ala 
    1520                 1525                 1530             


Glu Thr  Thr Val Arg Leu Arg  Ala Tyr Met Asn Thr  Pro Gly Leu 
    1535                 1540                 1545             


Pro Val  Cys Gln Asp His Leu  Glu Phe Trp Glu Gly  Val Phe Thr 
    1550                 1555                 1560             


Gly Leu  Thr His Ile Asp Ala  His Phe Leu Ser Gln  Thr Lys Gln 
    1565                 1570                 1575             


Ser Gly  Glu Asn Phe Pro Tyr  Leu Val Ala Tyr Gln  Ala Thr Val 
    1580                 1585                 1590             


Cys Ala  Arg Ala Gln Ala Pro  Pro Pro Ser Trp Asp  Gln Met Trp 
    1595                 1600                 1605             


Lys Cys  Leu Thr Arg Leu Lys  Pro Thr Leu His Gly  Pro Thr Pro 
    1610                 1615                 1620             


Leu Leu  Tyr Arg Leu Gly Ala  Val Gln Asn Glu Val  Thr Leu Thr 
    1625                 1630                 1635             


His Pro  Ile Thr Lys Tyr Ile  Met Thr Cys Met Ser  Ala Asp Leu 
    1640                 1645                 1650             


Glu Val  Val Thr Ser Thr Trp  Val Leu Val Gly Gly  Val Leu Ala 
    1655                 1660                 1665             


Ala Leu  Ala Ser Tyr Cys Leu  Ser Thr Gly Cys Val  Val Ile Val 
    1670                 1675                 1680             


Gly Arg  Ile Val Leu Ser Gly  Lys Pro Ala Ile Ile  Pro Asp Arg 
    1685                 1690                 1695             


Glu Val  Leu Tyr Arg Glu Phe  Asp Glu Met Glu Glu  Cys Ser Gln 
    1700                 1705                 1710             


His Leu  Pro Tyr Ile Glu Gln  Gly Met Met Leu Ala  Glu Gln Phe 
    1715                 1720                 1725             


Lys Gln  Lys Ala Leu Gly Leu  Leu Gln Thr Ala Ser  Arg Gln Ala 
    1730                 1735                 1740             


Glu Val  Val Ala Pro Ala Val  Gln Thr Asn Trp Gln  Lys Leu Glu 
    1745                 1750                 1755             


Ala Phe  Trp Ala Lys His Met  Trp Asn Phe Ile Ser  Gly Ile His 
    1760                 1765                 1770             


Tyr Leu  Ala Gly Leu Ser Thr  Leu Pro Gly Asn Pro  Ala Ile Ala 
    1775                 1780                 1785             


Ser Leu  Met Ala Phe Thr Ala  Ala Val Thr Ser Pro  Leu Thr Thr 
    1790                 1795                 1800             


Ser Gln  Thr Leu Leu Phe Asn  Ile Leu Gly Gly Trp  Val Ala Ala 
    1805                 1810                 1815             


Gln Leu  Ala Ala Pro Gly Ala  Ala Thr Ala Phe Val  Gly Ala Gly 
    1820                 1825                 1830             


Leu Ala  Gly Ala Ala Ile Gly  Ser Val Gly Leu Gly  Lys Val Leu 
    1835                 1840                 1845             


Val Asp  Ile Leu Ala Gly Tyr  Gly Ala Gly Val Ala  Gly Ala Leu 
    1850                 1855                 1860             


Val Ala  Phe Lys Ile Met Ser  Gly Glu Val Pro Ser  Thr Glu Asp 
    1865                 1870                 1875             


Leu Val  Asn Leu Leu Pro Ala  Ile Leu Ser Pro Gly  Ala Leu Val 
    1880                 1885                 1890             


Val Gly  Val Val Cys Ala Ala  Ile Leu Arg Arg His  Val Gly Pro 
    1895                 1900                 1905             


Gly Glu  Gly Ala Val Gln Trp  Met Asn Arg Leu Ile  Ala Phe Ala 
    1910                 1915                 1920             


Ser Arg  Gly Ser His Val Ser  Pro Thr His Tyr Val  Pro Glu Ser 
    1925                 1930                 1935             


Asp Ala  Ala Ala Arg Val Thr  Thr Ile Leu Ser Ser  Leu Thr Val 
    1940                 1945                 1950             


Thr Gln  Leu Leu Arg Arg Leu  His Gln Trp Ile Ser  Ser Glu Cys 
    1955                 1960                 1965             


Thr Thr  Pro Cys Ser Gly Ser  Trp Leu Arg Asp Ile  Trp Asp Trp 
    1970                 1975                 1980             


Ile Cys  Glu Val Leu Ser Asp  Phe Lys Thr Trp Leu  Lys Ala Lys 
    1985                 1990                 1995             


Leu Met  Pro Gln Leu Pro Gly  Ile Pro Phe Val Ser  Cys Gln Arg 
    2000                 2005                 2010             


Gly Tyr  Lys Gly Val Trp Arg  Gly Asp Gly Ile Met  His Thr Arg 
    2015                 2020                 2025             


Cys His  Cys Gly Ala Glu Ile  Thr Gly His Val Lys  Asn Gly Thr 
    2030                 2035                 2040             


Met Arg  Ile Val Gly Pro Lys  Thr Cys Arg Asn Met  Trp Ser Gly 
    2045                 2050                 2055             


Thr Phe  Pro Ile Asn Ala Tyr  Thr Thr Gly Pro Cys  Thr Pro Leu 
    2060                 2065                 2070             


Pro Ala  Pro Asn Tyr Thr Phe  Ala Leu Trp Arg Val  Ser Ala Glu 
    2075                 2080                 2085             


Glu Tyr  Val Glu Ile Arg Gln  Val Gly Asp Phe His  Tyr Val Thr 
    2090                 2095                 2100             


Gly Met  Thr Thr Asp Asn Leu  Lys Cys Pro Cys Gln  Val Pro Ser 
    2105                 2110                 2115             


Pro Glu  Phe Phe Thr Glu Leu  Asp Gly Val Arg Leu  His Arg Phe 
    2120                 2125                 2130             


Ala Pro  Pro Cys Lys Pro Leu  Leu Arg Glu Glu Val  Ser Phe Arg 
    2135                 2140                 2145             


Val Gly  Leu His Glu Tyr Pro  Val Gly Ser Gln Leu  Pro Cys Glu 
    2150                 2155                 2160             


Pro Glu  Pro Asp Val Ala Val  Leu Thr Ser Met Leu  Thr Asp Pro 
    2165                 2170                 2175             


Ser His  Ile Thr Ala Glu Ala  Ala Gly Arg Arg Leu  Ala Arg Gly 
    2180                 2185                 2190             


Ser Pro  Pro Ser Met Ala Ser  Ser Ser Ala Ser Gln  Leu Ser Ala 
    2195                 2200                 2205             


Pro Ser  Leu Arg Ala Thr Cys  Thr Thr Asn His Asp  Ser Pro Asp 
    2210                 2215                 2220             


Ala Glu  Leu Ile Glu Ala Asn  Leu Leu Trp Arg Gln  Glu Met Gly 
    2225                 2230                 2235             


Gly Asn  Ile Thr Arg Val Glu  Ser Glu Asn Lys Val  Val Ile Leu 
    2240                 2245                 2250             


Asp Ser  Phe Asp Pro Leu Val  Ala Glu Glu Asp Glu  Arg Glu Val 
    2255                 2260                 2265             


Ser Val  Pro Ala Glu Ile Leu  Arg Lys Ser Arg Lys  Phe Thr Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ile Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Pro  Trp Lys Lys Pro Asp  Tyr Glu Pro Pro Val  Val His Gly 
    2300                 2305                 2310             


Cys Pro  Leu Pro Pro Pro Gln  Ser Pro Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Lys Lys  Arg Thr Val Ile Leu  Thr Glu Ser Thr Leu  Pro Thr Ala 
    2330                 2335                 2340             


Leu Ala  Glu Leu Ala Thr Lys  Ser Phe Gly Ser Ser  Ser Thr Ser 
    2345                 2350                 2355             


Gly Ile  Thr Gly Asp Asp Thr  Thr Thr Ser Pro Glu  Pro Ala Ser 
    2360                 2365                 2370             


Ser Ser  Cys Pro Pro Asp Ser  Asp Ala Glu Ser Tyr  Ser Ser Met 
    2375                 2380                 2385             


Pro Pro  Leu Glu Gly Glu Pro  Gly Asp Pro Asp Leu  Ser Asp Gly 
    2390                 2395                 2400             


Ser Trp  Ser Thr Val Ser Ser  Glu Ala Asp Lys Glu  Asp Val Val 
    2405                 2410                 2415             


Cys Cys  Ser Met Ser Tyr Thr  Trp Thr Gly Ala Leu  Val Thr Pro 
    2420                 2425                 2430             


Cys Ala  Ala Glu Glu Gln Lys  Leu Pro Ile Asn Ala  Leu Ser Asn 
    2435                 2440                 2445             


Ser Leu  Leu Arg His His Asn  Leu Val Tyr Ser Thr  Thr Ser Arg 
    2450                 2455                 2460             


Ser Ala  Cys Gln Arg Gln Lys  Lys Val Thr Phe Asp  Arg Leu Gln 
    2465                 2470                 2475             


Val Leu  Asp Ser His Tyr Gln  Asp Val Leu Lys Glu  Val Lys Ala 
    2480                 2485                 2490             


Ala Ala  Ser Lys Val Lys Ala  Asn Leu Leu Ser Val  Glu Glu Ala 
    2495                 2500                 2505             


Cys Ser  Leu Thr Pro Pro His  Ser Ala Lys Ser Lys  Phe Gly Tyr 
    2510                 2515                 2520             


Gly Ala  Lys Asp Val Arg Cys  His Ala Arg Lys Ala  Val Asn His 
    2525                 2530                 2535             


Ile Asn  Ser Val Trp Lys Asp  Leu Leu Glu Asp Ser  Val Thr Pro 
    2540                 2545                 2550             


Ile Asp  Thr Thr Ile Met Ala  Lys Asn Glu Val Phe  Cys Val Gln 
    2555                 2560                 2565             


Pro Glu  Lys Gly Gly Arg Lys  Pro Ala Arg Leu Ile  Val Phe Pro 
    2570                 2575                 2580             


Asp Leu  Gly Val Arg Val Cys  Glu Lys Met Ala Leu  Tyr Asp Val 
    2585                 2590                 2595             


Val Ser  Lys Leu Pro Leu Ala  Val Met Gly Ser Ser  Tyr Gly Phe 
    2600                 2605                 2610             


Gln Tyr  Ser Pro Gly Gln Arg  Val Glu Phe Leu Val  Gln Ala Trp 
    2615                 2620                 2625             


Lys Ser  Lys Lys Thr Pro Met  Gly Phe Ser Tyr Asp  Thr Arg Cys 
    2630                 2635                 2640             


Phe Asp  Ser Thr Val Thr Glu  Asn Asp Ile Arg Thr  Glu Glu Ala 
    2645                 2650                 2655             


Ile Tyr  Gln Cys Cys Asp Leu  Asp Pro Gln Ala Arg  Val Ala Ile 
    2660                 2665                 2670             


Lys Ser  Leu Thr Glu Arg Leu  Tyr Val Gly Gly Pro  Leu Thr Asn 
    2675                 2680                 2685             


Ser Arg  Gly Glu Asn Cys Gly  Tyr Arg Arg Cys Arg  Ala Ser Gly 
    2690                 2695                 2700             


Val Leu  Thr Thr Ser Cys Gly  Asn Thr Leu Thr Cys  Tyr Ile Lys 
    2705                 2710                 2715             


Ala Arg  Ala Ala Cys Arg Ala  Ala Gly Leu Gln Asp  Cys Thr Met 
    2720                 2725                 2730             


Leu Val  Cys Gly Asp Asp Leu  Val Val Ile Cys Glu  Ser Ala Gly 
    2735                 2740                 2745             


Val Gln  Glu Asp Ala Ala Ser  Leu Arg Ala Phe Thr  Glu Ala Met 
    2750                 2755                 2760             


Thr Arg  Tyr Ser Ala Pro Pro  Gly Asp Pro Pro Gln  Pro Glu Tyr 
    2765                 2770                 2775             


Asp Leu  Glu Leu Ile Thr Ser  Cys Ser Ser Asn Val  Ser Val Ala 
    2780                 2785                 2790             


His Asp  Gly Ala Gly Lys Arg  Val Tyr Tyr Leu Thr  Arg Asp Pro 
    2795                 2800                 2805             


Thr Thr  Pro Leu Ala Arg Ala  Ala Trp Glu Thr Ala  Arg His Thr 
    2810                 2815                 2820             


Pro Val  Asn Ser Trp Leu Gly  Asn Ile Ile Met Phe  Ala Pro Thr 
    2825                 2830                 2835             


Leu Trp  Ala Arg Met Ile Leu  Met Thr His Phe Phe  Ser Val Leu 
    2840                 2845                 2850             


Ile Ala  Arg Asp Gln Leu Glu  Gln Ala Leu Asp Cys  Glu Ile Tyr 
    2855                 2860                 2865             


Gly Ala  Cys Tyr Ser Ile Glu  Pro Leu Asp Leu Pro  Pro Ile Ile 
    2870                 2875                 2880             


Gln Arg  Leu His Gly Leu Ser  Ala Phe Ser Leu His  Ser Tyr Ser 
    2885                 2890                 2895             


Pro Gly  Glu Ile Asn Arg Val  Ala Ala Cys Leu Arg  Lys Leu Gly 
    2900                 2905                 2910             


Val Pro  Pro Leu Arg Ala Trp  Arg His Arg Ala Arg  Asn Val Arg 
    2915                 2920                 2925             


Ala Arg  Leu Leu Ser Arg Gly  Gly Arg Ala Ala Ile  Cys Gly Lys 
    2930                 2935                 2940             


Tyr Leu  Phe Asn Trp Ala Val  Arg Thr Lys Leu Lys  Leu Thr Pro 
    2945                 2950                 2955             


Ile Ala  Ala Ala Gly Arg Leu  Asp Leu Ser Gly Trp  Phe Thr Ala 
    2960                 2965                 2970             


Gly Tyr  Ser Gly Gly Gly Ile  Phe His Ser Val Ser  His Ala Arg 
    2975                 2980                 2985             


Pro Arg  Trp Phe Trp Ser Cys  Leu Leu Leu Leu Ala  Ala Gly Val 
    2990                 2995                 3000             


Gly Ile  Tyr Leu Leu Pro Asn  Arg 
    3005                 3010     


<210>  158
<211>  3011
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  plasmid

<400>  158

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Gly Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Thr Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Phe Glu Ala Ala Asp Ala Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Val Thr Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Thr Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Ser Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Ala Leu Leu Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Met Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr Tyr Val Thr Gly Gly Ser Ala Ala Arg Thr Thr Ala Gly Leu Ala 
385                 390                 395                 400 


Ser Leu Phe Ser Pro Gly Ala Lys Gln Asn Ile Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Asn Thr Gly Trp Ile Ala Gly Leu Phe Tyr His His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Ser Glu Arg Leu Ala Ser Cys Arg Pro Leu Thr Asp 
    450                 455                 460                 


Phe Ala Gln Gly Trp Gly Pro Ile Ser His Ala Asp Gly Ser Gly Pro 
465                 470                 475                 480 


Asp Gln Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Lys Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly Ala Pro Thr Tyr Ser 
        515                 520                 525             


Trp Gly Ala Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu Arg Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Ile Asn Tyr 
    610                 615                 620                 


Thr Val Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Glu Ala Ala Cys Asn Trp Thr Arg Gly Asp Arg Cys Asn Leu Asp Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Ile Ala Ser Trp Ala Ile Lys Trp Glu Tyr Val Val 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Val Glu Ala Ala Leu Glu Asn Leu Val 
            740                 745                 750         


Val Leu Asn Ala Ala Ser Leu Ala Gly Thr His Gly Leu Val Ser Phe 
        755                 760                 765             


Leu Val Phe Phe Cys Phe Ala Trp Tyr Leu Lys Gly Lys Trp Val Pro 
    770                 775                 780                 


Gly Ala Val Tyr Ala Leu Tyr Gly Met Trp Pro Leu Leu Leu Leu Leu 
785                 790                 795                 800 


Leu Ala Leu Pro Gln Arg Ala Tyr Ala Leu Asp Thr Glu Val Ala Ala 
                805                 810                 815     


Ser Cys Gly Gly Val Val Leu Val Gly Leu Met Ala Leu Thr Leu Ser 
            820                 825                 830         


Pro Tyr Tyr Lys Arg Tyr Ile Ser Trp Cys Leu Trp Trp Leu Gln Tyr 
        835                 840                 845             


Phe Leu Thr Arg Ile Glu Ala Gln Leu His Val Trp Ile Pro Pro Leu 
    850                 855                 860                 


Asn Val Arg Gly Gly Arg Asp Ala Val Ile Leu Leu Met Cys Val Val 
865                 870                 875                 880 


His Pro Ala Leu Val Phe Asp Ile Thr Lys Leu Leu Leu Ala Ala Phe 
                885                 890                 895     


Gly Pro Leu Trp Ile Leu Gln Ala Ser Leu Leu Lys Val Pro Tyr Phe 
            900                 905                 910         


Val Arg Val Gln Gly Leu Leu Arg Ile Cys Ala Leu Ala Arg Lys Met 
        915                 920                 925             


Ala Gly Gly His Tyr Val Gln Met Ala Ile Ile Lys Leu Gly Ala Leu 
    930                 935                 940                 


Thr Gly Thr Tyr Val Tyr Asn His Leu Thr Pro Leu Arg Asp Trp Ala 
945                 950                 955                 960 


His Asn Gly Leu Arg Asp Leu Ala Val Ala Val Glu Pro Val Val Phe 
                965                 970                 975     


Ser Arg Met Glu Thr Lys Leu Ile Thr Trp Gly Ala Asp Thr Ala Ala 
            980                 985                 990         


Cys Gly Asp Ile Ile Asn Gly Leu  Pro Val Ser Ala Arg  Arg Gly Arg 
        995                 1000                 1005             


Glu Ile  Leu Leu Gly Pro Ala  Asp Gly Met Val Ser  Lys Gly Trp 
    1010                 1015                 1020             


Arg Leu  Leu Ala Pro Ile Thr  Ala Tyr Ala Gln Gln  Thr Arg Gly 
    1025                 1030                 1035             


Leu Leu  Gly Cys Ile Ile Thr  Ser Leu Thr Gly Arg  Asp Lys Asn 
    1040                 1045                 1050             


Gln Val  Glu Gly Glu Ile Gln  Ile Val Ser Thr Ala  Ala Gln Thr 
    1055                 1060                 1065             


Phe Leu  Ala Thr Cys Ile Asn  Gly Val Cys Trp Thr  Val Tyr His 
    1070                 1075                 1080             


Gly Ala  Gly Thr Arg Thr Ile  Ala Ser Pro Lys Gly  Pro Val Ile 
    1085                 1090                 1095             


Gln Met  Tyr Thr Asn Val Asp  Lys Asp Leu Val Gly  Trp Pro Ala 
    1100                 1105                 1110             


Pro Gln  Gly Ala Arg Ser Leu  Thr Pro Cys Thr Cys  Gly Ser Ser 
    1115                 1120                 1125             


Asp Leu  Tyr Leu Val Thr Arg  His Ala Asp Val Ile  Pro Val Arg 
    1130                 1135                 1140             


Arg Arg  Gly Asp Ser Arg Gly  Ser Leu Leu Ser Pro  Arg Pro Ile 
    1145                 1150                 1155             


Ser Tyr  Leu Lys Gly Ser Ser  Gly Gly Pro Leu Leu  Cys Pro Ala 
    1160                 1165                 1170             


Gly His  Ala Val Gly Leu Phe  Arg Ala Ala Val Cys  Thr Arg Gly 
    1175                 1180                 1185             


Val Ala  Lys Ala Val Asp Phe  Ile Pro Val Glu Asn  Leu Glu Thr 
    1190                 1195                 1200             


Thr Met  Arg Ser Pro Val Phe  Thr Asp Asn Ser Ser  Pro Pro Ala 
    1205                 1210                 1215             


Val Pro  Gln Ser Phe Gln Val  Gly His Leu His Ala  Pro Thr Gly 
    1220                 1225                 1230             


Ser Gly  Lys Ser Thr Lys Val  Pro Ala Ala Tyr Ala  Ala Gln Gly 
    1235                 1240                 1245             


Tyr Lys  Val Leu Val Leu Asn  Pro Ser Val Ala Ala  Thr Leu Gly 
    1250                 1255                 1260             


Phe Gly  Ala Tyr Met Ser Lys  Ala His Gly Val Asp  Pro Asn Ile 
    1265                 1270                 1275             


Arg Thr  Gly Val Arg Thr Ile  Thr Thr Gly Ser Pro  Ile Thr Tyr 
    1280                 1285                 1290             


Ser Thr  Tyr Gly Lys Phe Leu  Ala Asp Gly Gly Cys  Ser Gly Gly 
    1295                 1300                 1305             


Ala Tyr  Asp Ile Ile Ile Cys  Asp Glu Cys His Ser  Thr Asp Ala 
    1310                 1315                 1320             


Thr Ser  Ile Leu Gly Ile Gly  Thr Val Leu Asp Gln  Ala Glu Thr 
    1325                 1330                 1335             


Ala Gly  Ala Arg Leu Val Val  Leu Ala Thr Ala Thr  Pro Pro Gly 
    1340                 1345                 1350             


Ser Ile  Thr Val Pro His Pro  Asn Ile Glu Glu Val  Ala Leu Ser 
    1355                 1360                 1365             


Thr Thr  Gly Glu Ile Pro Phe  Tyr Gly Lys Ala Ile  Pro Leu Glu 
    1370                 1375                 1380             


Ala Ile  Lys Gly Gly Arg His  Leu Ile Phe Cys His  Ser Lys Lys 
    1385                 1390                 1395             


Lys Cys  Asp Glu Leu Ala Ala  Lys Leu Val Ala Leu  Gly Ile Asn 
    1400                 1405                 1410             


Ala Val  Ala Tyr Tyr Arg Gly  Leu Asp Val Ser Val  Ile Pro Thr 
    1415                 1420                 1425             


Ser Gly  Asp Val Val Val Val  Ala Thr Asp Ala Leu  Met Thr Gly 
    1430                 1435                 1440             


Tyr Thr  Gly Asp Phe Asp Ser  Val Ile Asp Cys Asn  Thr Cys Val 
    1445                 1450                 1455             


Thr Gln  Thr Val Asp Leu Ser  Leu Asp Pro Thr Phe  Thr Ile Glu 
    1460                 1465                 1470             


Thr Thr  Thr Leu Pro Gln Asp  Ala Val Ser Arg Thr  Gln Arg Arg 
    1475                 1480                 1485             


Gly Arg  Thr Gly Arg Gly Lys  Pro Gly Ile Tyr Arg  Phe Val Ala 
    1490                 1495                 1500             


Leu Gly  Glu Arg Pro Ser Gly  Met Phe Asp Ser Ser  Val Leu Cys 
    1505                 1510                 1515             


Glu Cys  Tyr Asp Ala Gly Cys  Ala Trp Tyr Glu Leu  Thr Pro Ala 
    1520                 1525                 1530             


Glu Thr  Thr Val Arg Leu Arg  Ala Tyr Met Asn Thr  Pro Gly Leu 
    1535                 1540                 1545             


Pro Val  Cys Gln Asp His Leu  Glu Phe Trp Glu Gly  Val Phe Thr 
    1550                 1555                 1560             


Gly Leu  Thr His Ile Asp Ala  His Phe Leu Ser Gln  Thr Lys Gln 
    1565                 1570                 1575             


Ser Gly  Glu Asn Phe Pro Tyr  Leu Val Ala Tyr Gln  Ala Thr Val 
    1580                 1585                 1590             


Cys Ala  Arg Ala Gln Ala Pro  Pro Pro Ser Trp Asp  Gln Met Trp 
    1595                 1600                 1605             


Lys Cys  Leu Thr Arg Leu Lys  Pro Thr Leu His Gly  Pro Thr Pro 
    1610                 1615                 1620             


Leu Leu  Tyr Arg Leu Gly Ala  Val Gln Asn Glu Val  Thr Leu Thr 
    1625                 1630                 1635             


His Pro  Ile Thr Lys Tyr Ile  Met Thr Cys Met Ser  Ala Asp Leu 
    1640                 1645                 1650             


Glu Val  Val Thr Ser Thr Trp  Val Leu Val Gly Gly  Val Leu Ala 
    1655                 1660                 1665             


Ala Leu  Ala Ser Tyr Cys Leu  Ser Thr Gly Cys Val  Val Ile Val 
    1670                 1675                 1680             


Gly Arg  Ile Val Leu Ser Gly  Lys Pro Ala Ile Ile  Pro Asp Arg 
    1685                 1690                 1695             


Glu Val  Leu Tyr Arg Glu Phe  Asp Glu Met Glu Glu  Cys Ser Gln 
    1700                 1705                 1710             


His Leu  Pro Tyr Ile Glu Gln  Gly Met Met Leu Ala  Glu Gln Phe 
    1715                 1720                 1725             


Lys Gln  Lys Ala Leu Gly Leu  Leu Gln Thr Ala Ser  Arg Gln Ala 
    1730                 1735                 1740             


Glu Val  Val Ala Pro Ala Val  Gln Thr Asn Trp Gln  Lys Leu Glu 
    1745                 1750                 1755             


Ala Phe  Trp Ala Lys His Met  Trp Asn Phe Ile Ser  Gly Ile His 
    1760                 1765                 1770             


Tyr Leu  Ala Gly Leu Ser Thr  Leu Pro Gly Asn Pro  Ala Ile Ala 
    1775                 1780                 1785             


Ser Leu  Met Ala Phe Thr Ala  Ala Val Thr Ser Pro  Leu Thr Thr 
    1790                 1795                 1800             


Ser Gln  Thr Leu Leu Phe Asn  Ile Leu Gly Gly Trp  Val Ala Ala 
    1805                 1810                 1815             


Gln Leu  Ala Ala Pro Gly Ala  Ala Thr Ala Phe Val  Gly Ala Gly 
    1820                 1825                 1830             


Leu Ala  Gly Ala Ala Ile Gly  Ser Val Gly Leu Gly  Lys Val Leu 
    1835                 1840                 1845             


Val Asp  Ile Leu Ala Gly Tyr  Gly Ala Gly Val Ala  Gly Ala Leu 
    1850                 1855                 1860             


Val Ala  Phe Lys Ile Met Ser  Gly Glu Val Pro Ser  Thr Glu Asp 
    1865                 1870                 1875             


Leu Val  Asn Leu Leu Pro Ala  Ile Leu Ser Pro Gly  Ala Leu Val 
    1880                 1885                 1890             


Val Gly  Val Val Cys Ala Ala  Ile Leu Arg Arg His  Val Gly Pro 
    1895                 1900                 1905             


Gly Glu  Gly Ala Val Gln Trp  Met Asn Arg Leu Ile  Ala Phe Ala 
    1910                 1915                 1920             


Ser Arg  Gly Thr His Val Ser  Pro Thr His Tyr Val  Pro Glu Ser 
    1925                 1930                 1935             


Asp Ala  Ala Ala Arg Val Thr  Thr Ile Leu Ser Ser  Leu Thr Val 
    1940                 1945                 1950             


Thr Gln  Leu Leu Arg Arg Leu  His Gln Trp Ile Ser  Ser Glu Cys 
    1955                 1960                 1965             


Thr Thr  Pro Cys Ser Gly Ser  Trp Leu Arg Asp Ile  Trp Asp Trp 
    1970                 1975                 1980             


Ile Cys  Glu Val Leu Ser Asp  Phe Lys Thr Trp Leu  Lys Ala Lys 
    1985                 1990                 1995             


Leu Met  Pro Gln Leu Pro Gly  Ile Pro Phe Val Ser  Cys Gln Arg 
    2000                 2005                 2010             


Gly Tyr  Lys Gly Val Trp Arg  Gly Asp Gly Ile Met  His Thr Arg 
    2015                 2020                 2025             


Cys His  Cys Gly Ala Glu Ile  Thr Gly His Val Lys  Asn Gly Thr 
    2030                 2035                 2040             


Met Arg  Ile Val Gly Pro Lys  Thr Cys Arg Asn Met  Trp Ser Gly 
    2045                 2050                 2055             


Thr Phe  Pro Ile Asn Ala Tyr  Thr Thr Gly Pro Cys  Thr Pro Leu 
    2060                 2065                 2070             


Pro Ala  Pro Asn Tyr Thr Phe  Ala Leu Trp Arg Val  Ser Ala Glu 
    2075                 2080                 2085             


Glu Tyr  Val Glu Ile Arg Gln  Val Gly Asp Phe His  Tyr Val Thr 
    2090                 2095                 2100             


Gly Met  Thr Thr Asp Asn Leu  Lys Cys Pro Cys Gln  Val Pro Ser 
    2105                 2110                 2115             


Pro Glu  Phe Phe Thr Glu Leu  Asp Gly Val Arg Leu  His Arg Phe 
    2120                 2125                 2130             


Ala Pro  Pro Cys Lys Pro Leu  Leu Arg Glu Glu Val  Ser Phe Arg 
    2135                 2140                 2145             


Val Gly  Leu His Glu Tyr Pro  Val Gly Ser Gln Leu  Pro Cys Glu 
    2150                 2155                 2160             


Pro Glu  Pro Asp Val Ala Val  Leu Thr Ser Met Leu  Thr Asp Pro 
    2165                 2170                 2175             


Ser His  Ile Thr Ala Glu Ala  Ala Gly Arg Arg Leu  Ala Arg Gly 
    2180                 2185                 2190             


Ser Pro  Pro Ser Met Ala Ser  Ser Ser Ala Ser Gln  Leu Ser Ala 
    2195                 2200                 2205             


Pro Ser  Leu Arg Ala Thr Cys  Thr Thr Asn His Asp  Ser Pro Asp 
    2210                 2215                 2220             


Ala Glu  Leu Ile Glu Ala Asn  Leu Leu Trp Arg Gln  Glu Met Gly 
    2225                 2230                 2235             


Gly Asn  Ile Thr Arg Val Glu  Ser Glu Asn Lys Val  Val Ile Leu 
    2240                 2245                 2250             


Asp Ser  Phe Asp Pro Leu Val  Ala Glu Glu Asp Glu  Arg Glu Val 
    2255                 2260                 2265             


Ser Val  Pro Ala Glu Ile Leu  Arg Lys Ser Arg Lys  Phe Thr Pro 
    2270                 2275                 2280             


Ala Leu  Pro Ile Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Pro  Trp Lys Lys Pro Asp  Tyr Glu Pro Pro Val  Val His Gly 
    2300                 2305                 2310             


Cys Pro  Leu Pro Pro Pro Gln  Ser Pro Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Lys Lys  Arg Thr Val Ile Leu  Thr Glu Ser Thr Leu  Pro Thr Ala 
    2330                 2335                 2340             


Leu Ala  Glu Leu Ala Thr Lys  Ser Phe Gly Ser Ser  Ser Thr Ser 
    2345                 2350                 2355             


Gly Ile  Thr Gly Asp Asp Thr  Thr Thr Ser Pro Glu  Pro Ala Ser 
    2360                 2365                 2370             


Ser Ser  Cys Pro Pro Asp Ser  Asp Ala Glu Ser Tyr  Ser Ser Met 
    2375                 2380                 2385             


Pro Pro  Leu Glu Gly Glu Pro  Gly Asp Pro Asp Leu  Ser Asp Gly 
    2390                 2395                 2400             


Ser Trp  Ser Thr Val Ser Ser  Glu Ala Asp Lys Glu  Asp Val Val 
    2405                 2410                 2415             


Cys Cys  Ser Met Ser Tyr Thr  Trp Thr Gly Ala Leu  Val Thr Pro 
    2420                 2425                 2430             


Cys Ala  Ala Glu Glu Gln Lys  Leu Pro Ile Asn Ala  Leu Ser Asn 
    2435                 2440                 2445             


Ser Leu  Leu Arg His His Asn  Leu Val Tyr Ser Thr  Thr Ser Arg 
    2450                 2455                 2460             


Ser Ala  Cys Gln Arg Gln Lys  Lys Val Thr Phe Asp  Arg Leu Gln 
    2465                 2470                 2475             


Val Leu  Asp Ser His Tyr Gln  Asp Val Leu Lys Glu  Val Lys Ala 
    2480                 2485                 2490             


Ala Ala  Ser Lys Val Lys Ala  Asn Leu Leu Ser Val  Glu Glu Ala 
    2495                 2500                 2505             


Cys Ser  Leu Thr Pro Pro His  Ser Ala Lys Ser Lys  Phe Gly Tyr 
    2510                 2515                 2520             


Gly Ala  Lys Asp Val Arg Cys  His Ala Arg Lys Ala  Val Asn His 
    2525                 2530                 2535             


Ile Asn  Ser Val Trp Lys Asp  Leu Leu Glu Asp Ser  Val Thr Pro 
    2540                 2545                 2550             


Ile Asp  Thr Thr Ile Met Ala  Lys Asn Glu Val Phe  Cys Val Gln 
    2555                 2560                 2565             


Pro Glu  Lys Gly Gly Arg Lys  Pro Ala Arg Leu Ile  Val Phe Pro 
    2570                 2575                 2580             


Asp Leu  Gly Val Arg Val Cys  Glu Lys Met Ala Leu  Tyr Asp Val 
    2585                 2590                 2595             


Val Ser  Lys Leu Pro Leu Ala  Val Met Gly Ser Ser  Tyr Gly Phe 
    2600                 2605                 2610             


Gln Tyr  Ser Pro Gly Gln Arg  Val Glu Phe Leu Val  Gln Ala Trp 
    2615                 2620                 2625             


Lys Ser  Lys Lys Thr Pro Met  Gly Phe Ser Tyr Asp  Thr Arg Cys 
    2630                 2635                 2640             


Phe Asp  Ser Thr Val Thr Glu  Asn Asp Ile Arg Thr  Glu Glu Ala 
    2645                 2650                 2655             


Ile Tyr  Gln Cys Cys Asp Leu  Asp Pro Gln Ala Arg  Val Ala Ile 
    2660                 2665                 2670             


Lys Ser  Leu Thr Glu Arg Leu  Tyr Val Gly Gly Pro  Leu Thr Asn 
    2675                 2680                 2685             


Ser Arg  Gly Glu Asn Cys Gly  Tyr Arg Arg Cys Arg  Ala Ser Gly 
    2690                 2695                 2700             


Val Leu  Thr Thr Ser Cys Gly  Asn Thr Leu Thr Cys  Tyr Ile Lys 
    2705                 2710                 2715             


Ala Arg  Ala Ala Cys Arg Ala  Ala Gly Leu Gln Asp  Cys Thr Met 
    2720                 2725                 2730             


Leu Val  Cys Gly Asp Asp Leu  Val Val Ile Cys Glu  Ser Ala Gly 
    2735                 2740                 2745             


Val Gln  Glu Asp Ala Ala Ser  Leu Arg Ala Phe Thr  Glu Ala Met 
    2750                 2755                 2760             


Thr Arg  Tyr Ser Ala Pro Pro  Gly Asp Pro Pro Gln  Pro Glu Tyr 
    2765                 2770                 2775             


Asp Leu  Glu Leu Ile Thr Ser  Cys Ser Ser Asn Val  Ser Val Ala 
    2780                 2785                 2790             


His Asp  Gly Ala Gly Lys Arg  Val Tyr Tyr Leu Thr  Arg Asp Pro 
    2795                 2800                 2805             


Thr Thr  Pro Leu Ala Arg Ala  Ala Trp Glu Thr Ala  Arg His Thr 
    2810                 2815                 2820             


Pro Val  Asn Ser Trp Leu Gly  Asn Ile Ile Met Phe  Ala Pro Thr 
    2825                 2830                 2835             


Leu Trp  Ala Arg Met Ile Leu  Met Thr His Phe Phe  Ser Val Leu 
    2840                 2845                 2850             


Ile Ala  Arg Asp Gln Leu Glu  Gln Ala Leu Asp Cys  Glu Ile Tyr 
    2855                 2860                 2865             


Gly Ala  Cys Tyr Ser Ile Glu  Pro Leu Asp Leu Pro  Pro Ile Ile 
    2870                 2875                 2880             


Gln Arg  Leu His Gly Leu Ser  Ala Phe Ser Leu His  Ser Tyr Ser 
    2885                 2890                 2895             


Pro Gly  Glu Ile Asn Arg Val  Ala Ala Cys Leu Arg  Lys Leu Gly 
    2900                 2905                 2910             


Val Pro  Pro Leu Arg Ala Trp  Arg His Arg Ala Arg  Asn Val Arg 
    2915                 2920                 2925             


Ala Arg  Leu Leu Ser Arg Gly  Gly Arg Ala Ala Ile  Cys Gly Lys 
    2930                 2935                 2940             


Tyr Leu  Phe Asn Trp Ala Val  Arg Thr Lys Leu Lys  Leu Thr Pro 
    2945                 2950                 2955             


Ile Ala  Ala Ala Gly Arg Leu  Asp Leu Ser Gly Trp  Phe Thr Ala 
    2960                 2965                 2970             


Gly Tyr  Ser Gly Gly Gly Ile  Phe His Ser Val Ser  His Ala Arg 
    2975                 2980                 2985             


Pro Arg  Trp Phe Trp Ser Cys  Leu Leu Leu Leu Ala  Ala Gly Val 
    2990                 2995                 3000             


Gly Ile  Tyr Leu Leu Pro Asn  Arg 
    3005                 3010     


