                         SEQUENCE LISTING

<110>  Janssen Biotech, Inc.
       Zhou, Hong
 
<120>  Human Oncostatin M Antibodies and Methods of Use

<130>  CEN5318WOPCT

<140>  To be determined
<141>  Herewith

<150>  US 61/611,241
<151>  2012-03-15

<160>  208   

<170>  PatentIn version 3.5

<210>  1
<211>  98
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (33)..(33)
<223>  X may be Ala or Gly

<220>
<221>  VARIANT
<222>  (50)..(50)
<223>  X may be Gly or Trp

<220>
<221>  VARIANT
<222>  (52)..(52)
<223>  X may be Ile or Ser

<220>
<221>  VARIANT
<222>  (53)..(53)
<223>  X may be Ala or Pro

<220>
<221>  VARIANT
<222>  (54)..(54)
<223>  X may be Ile or Tyr

<220>
<221>  VARIANT
<222>  (55)..(55)
<223>  X may be Asn or Phe

<400>  1

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Xaa Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Xaa Ile Xaa Xaa Xaa Xaa Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  2
<211>  98
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (31)..(31)
<223>  X may be Asp, Asn,  Ser or Thr

<220>
<221>  VARIANT
<222>  (33)..(33)
<223>  X may be Asp, Gly, or Trp

<220>
<221>  VARIANT
<222>  (35)..(35)
<223>  X may be His or Ser

<220>
<221>  VARIANT
<222>  (50)..(50)
<223>  X may be Ala, Asn, Gly, or Val

<220>
<221>  VARIANT
<222>  (52)..(52)
<223>  X may be Asn, Lys, Ser, or Trp

<220>
<221>  VARIANT
<222>  (53)..(53)
<223>  X may be Gln, Gly, Ser, or Tyr

<220>
<221>  VARIANT
<222>  (54)..(54)
<223>  X may be Asp or Ser

<220>
<221>  VARIANT
<222>  (56)..(56)
<223>  X may be Gly or Ser

<400>  2

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Xaa Tyr 
            20                  25                  30          


Xaa Met Xaa Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Xaa Ile Xaa Xaa Xaa Gly Xaa Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys 
        


<210>  3
<211>  98
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (31)..(31)
<223>  X may be Asn, Ser or Thr

<220>
<221>  VARIANT
<222>  (35)..(35)
<223>  X may be Gly or Ser

<220>
<221>  VARIANT
<222>  (50)..(50)
<223>  X may be Arg or Ile

<220>
<221>  VARIANT
<222>  (52)..(52)
<223>  X may be Asp or Tyr

<220>
<221>  VARIANT
<222>  (54)..(54)
<223>  X may be Gly or Ser

<220>
<221>  VARIANT
<222>  (57)..(57)
<223>  X may be Asp or Tyr

<400>  3

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Xaa Tyr 
            20                  25                  30          


Trp Ile Xaa Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Xaa Ile Xaa Pro Xaa Asp Ser Xaa Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  4
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  4

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  5
<211>  88
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (30)..(30)
<223>  X may be Ala, Asp, Asn, Ser or Arg

<220>
<221>  VARIANT
<222>  (31)..(31)
<223>  X may be Asp, Gly, Lys, Asn, or Ser

<220>
<221>  VARIANT
<222>  (32)..(32)
<223>  X may be Ala, Asp, Phe, His, Asn, Ser Trp, Val or Tyr

<220>
<221>  VARIANT
<222>  (50)..(50)
<223>  X may be Ala, Asp, Phe, Gly, Asn, Lys, Thr or Tyr

<400>  5

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Xaa Xaa Xaa 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Xaa Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys 
                85              


<210>  6
<211>  88
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (30)..(30)
<223>  X may be Ala, Asn, Asp, Arg, or Ser

<220>
<221>  VARIANT
<222>  (31)..(31)
<223>  X may be  Asn,  Asp, Lys, or Ser

<220>
<221>  VARIANT
<222>  (32)..(32)
<223>  X may be  Ala, Asn,  Asp, His, Phe, Ser, Trp, or Tyr

<220>
<221>  VARIANT
<222>  (50)..(50)
<223>  X may be Ala, Asn, Asp, Gly, Lys, Phe, Thr, or Tyr

<400>  6

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Xaa Xaa Xaa 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Xaa Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys 
                85              


<210>  7
<211>  89
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (30)..(30)
<223>  X may be Asn, Asp, Arg, Ser, or Thr

<220>
<221>  VARIANT
<222>  (31)..(31)
<223>  X may be Asn, Arg, or Ser

<220>
<221>  VARIANT
<222>  (32)..(32)
<223>  X may be Ala, Asp, Asn, Arg, His, or Ser

<220>
<221>  VARIANT
<222>  (33)..(33)
<223>  X may be Glu, Gln, His, Lys, Phe, Ser, or Tyr

<220>
<221>  VARIANT
<222>  (51)..(51)
<223>  X may be Ala, Asp, Gly or Ser

<400>  7

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Xaa Xaa Xaa 
            20                  25                  30          


Xaa Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Xaa Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
                85                  


<210>  8
<211>  94
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (31)..(31)
<223>  X may be Ala, His, Phe, Ser, or Tyr

<220>
<221>  VARIANT
<222>  (36)..(36)
<223>  X may be Asn, Glu, Lys, or Thr

<220>
<221>  VARIANT
<222>  (38)..(38)
<223>  X may be Ala, Asp, Asn, His, Phe, Ser, Trp, or Tyr

<220>
<221>  VARIANT
<222>  (56)..(56)
<223>  X may be Ala, Asp, Arg, Ser, Trp, or Tyr

<400>  8

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Xaa Ser 
            20                  25                  30          


Ser Asn Asn Xaa Asn Xaa Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Xaa Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys 
                85                  90                  


<210>  9
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  X may be Ala, Asp, Arg, Gly, His, Phe, Pro, Ser, or Tyr

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  X may be Asp, Asn, Arg, Glu, Gly, His, Ile, Leu, Lys, Phe,  Ser, 
       or Tyr

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  X may be Asp, Asn, Arg, Gly, His, Lys, Thr, or Ser

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  X may be Ala, Arg, Gly, Leu, Phe, Pro, Ser, Thr, Trp, or Val

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  X may be Asn, Arg,  Ile, Leu, Phe, Trp, or Tyr

<400>  9

Gln Gln Xaa Xaa Xaa Xaa Pro Xaa Thr 
1               5                   


<210>  10
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  10

Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  11
<211>  863
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Arg Arg Ser Ser Phe Gln Ser Cys Gln Ile Ile Ser Leu Phe 
1               5                   10                  15      


Thr Phe Ala Val Gly Val Asn Ile Cys Leu Gly Phe Thr Ala His Arg 
            20                  25                  30          


Ile Lys Arg Ala Glu Gly Trp Glu Glu Gly Pro Pro Thr Val Leu Ser 
        35                  40                  45              


Asp Ser Pro Trp Thr Asn Ile Ser Gly Ser Cys Lys Gly Arg Cys Phe 
    50                  55                  60                  


Glu Leu Gln Glu Ala Gly Pro Pro Asp Cys Arg Cys Asp Asn Leu Cys 
65                  70                  75                  80  


Lys Ser Tyr Thr Ser Cys Cys His Asp Phe Asp Glu Leu Cys Leu Lys 
                85                  90                  95      


Thr Ala Arg Gly Trp Glu Cys Thr Lys Asp Arg Cys Gly Glu Val Arg 
            100                 105                 110         


Asn Glu Glu Asn Ala Cys His Cys Ser Glu Asp Cys Leu Ala Arg Gly 
        115                 120                 125             


Asp Cys Cys Thr Asn Tyr Gln Val Val Cys Lys Gly Glu Ser His Trp 
    130                 135                 140                 


Val Asp Asp Asp Cys Glu Glu Ile Lys Ala Ala Glu Cys Pro Ala Gly 
145                 150                 155                 160 


Phe Val Arg Pro Pro Leu Ile Ile Phe Ser Val Asp Gly Phe Arg Ala 
                165                 170                 175     


Ser Tyr Met Lys Lys Gly Ser Lys Val Met Pro Asn Ile Glu Lys Leu 
            180                 185                 190         


Arg Ser Cys Gly Thr His Ser Pro Tyr Met Arg Pro Val Tyr Pro Thr 
        195                 200                 205             


Lys Thr Phe Pro Asn Leu Tyr Thr Leu Ala Thr Gly Leu Tyr Pro Glu 
    210                 215                 220                 


Ser His Gly Ile Val Gly Asn Ser Met Tyr Asp Pro Val Phe Asp Ala 
225                 230                 235                 240 


Thr Phe His Leu Arg Gly Arg Glu Lys Phe Asn His Arg Trp Trp Gly 
                245                 250                 255     


Gly Gln Pro Leu Trp Ile Thr Ala Thr Lys Gln Gly Val Lys Ala Gly 
            260                 265                 270         


Thr Phe Phe Trp Ser Val Val Ile Pro His Glu Arg Arg Ile Leu Thr 
        275                 280                 285             


Ile Leu Gln Trp Leu Thr Leu Pro Asp His Glu Arg Pro Ser Val Tyr 
    290                 295                 300                 


Ala Phe Tyr Ser Glu Gln Pro Asp Phe Ser Gly His Lys Tyr Gly Pro 
305                 310                 315                 320 


Phe Gly Pro Glu Met Thr Asn Pro Leu Arg Glu Ile Asp Lys Ile Val 
                325                 330                 335     


Gly Gln Leu Met Asp Gly Leu Lys Gln Leu Lys Leu His Arg Cys Val 
            340                 345                 350         


Asn Val Ile Phe Val Gly Asp His Gly Met Glu Asp Val Thr Cys Asp 
        355                 360                 365             


Arg Thr Glu Phe Leu Ser Asn Tyr Leu Thr Asn Val Asp Asp Ile Thr 
    370                 375                 380                 


Leu Val Pro Gly Thr Leu Gly Arg Ile Arg Ser Lys Phe Ser Asn Asn 
385                 390                 395                 400 


Ala Lys Tyr Asp Pro Lys Ala Ile Ile Ala Asn Leu Thr Cys Lys Lys 
                405                 410                 415     


Pro Asp Gln His Phe Lys Pro Tyr Leu Lys Gln His Leu Pro Lys Arg 
            420                 425                 430         


Leu His Tyr Ala Asn Asn Arg Arg Ile Glu Asp Ile His Leu Leu Val 
        435                 440                 445             


Glu Arg Arg Trp His Val Ala Arg Lys Pro Leu Asp Val Tyr Lys Lys 
    450                 455                 460                 


Pro Ser Gly Lys Cys Phe Phe Gln Gly Asp His Gly Phe Asp Asn Lys 
465                 470                 475                 480 


Val Asn Ser Met Gln Thr Val Phe Val Gly Tyr Gly Ser Thr Phe Lys 
                485                 490                 495     


Tyr Lys Thr Lys Val Pro Pro Phe Glu Asn Ile Glu Leu Tyr Asn Val 
            500                 505                 510         


Met Cys Asp Leu Leu Gly Leu Lys Pro Ala Pro Asn Asn Gly Thr His 
        515                 520                 525             


Gly Ser Leu Asn His Leu Leu Arg Thr Asn Thr Phe Arg Pro Thr Met 
    530                 535                 540                 


Pro Glu Glu Val Thr Arg Pro Asn Tyr Pro Gly Ile Met Tyr Leu Gln 
545                 550                 555                 560 


Ser Asp Phe Asp Leu Gly Cys Thr Cys Asp Asp Lys Val Glu Pro Lys 
                565                 570                 575     


Asn Lys Leu Asp Glu Leu Asn Lys Arg Leu His Thr Lys Gly Ser Thr 
            580                 585                 590         


Glu Glu Arg His Leu Leu Tyr Gly Arg Pro Ala Val Leu Tyr Arg Thr 
        595                 600                 605             


Arg Tyr Asp Ile Leu Tyr His Thr Asp Phe Glu Ser Gly Tyr Ser Glu 
    610                 615                 620                 


Ile Phe Leu Met Pro Leu Trp Thr Ser Tyr Thr Val Ser Lys Gln Ala 
625                 630                 635                 640 


Glu Val Ser Ser Val Pro Asp His Leu Thr Ser Cys Val Arg Pro Asp 
                645                 650                 655     


Val Arg Val Ser Pro Ser Phe Ser Gln Asn Cys Leu Ala Tyr Lys Asn 
            660                 665                 670         


Asp Lys Gln Met Ser Tyr Gly Phe Leu Phe Pro Pro Tyr Leu Ser Ser 
        675                 680                 685             


Ser Pro Glu Ala Lys Tyr Asp Ala Phe Leu Val Thr Asn Met Val Pro 
    690                 695                 700                 


Met Tyr Pro Ala Phe Lys Arg Val Trp Asn Tyr Phe Gln Arg Val Leu 
705                 710                 715                 720 


Val Lys Lys Tyr Ala Ser Glu Arg Asn Gly Val Asn Val Ile Ser Gly 
                725                 730                 735     


Pro Ile Phe Asp Tyr Asp Tyr Asp Gly Leu His Asp Thr Glu Asp Lys 
            740                 745                 750         


Ile Lys Gln Tyr Val Glu Gly Ser Ser Ile Pro Val Pro Thr His Tyr 
        755                 760                 765             


Tyr Ser Ile Ile Thr Ser Cys Leu Asp Phe Thr Gln Pro Ala Asp Lys 
    770                 775                 780                 


Cys Asp Gly Pro Leu Ser Val Ser Ser Phe Ile Leu Pro His Arg Pro 
785                 790                 795                 800 


Asp Asn Glu Glu Ser Cys Asn Ser Ser Glu Asp Glu Ser Lys Trp Val 
                805                 810                 815     


Glu Glu Leu Met Lys Met His Thr Ala Arg Val Arg Asp Ile Glu His 
            820                 825                 830         


Leu Thr Ser Leu Asp Phe Phe Arg Lys Thr Ser Arg Ser Tyr Pro Glu 
        835                 840                 845             


Ile Leu Thr Leu Lys Thr Tyr Leu His Thr Tyr Glu Ser Glu Ile 
    850                 855                 860             


<210>  12
<211>  915
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Arg Arg Ser Ser Phe Gln Ser Cys Gln Ile Ile Ser Leu Phe 
1               5                   10                  15      


Thr Phe Ala Val Gly Val Asn Ile Cys Leu Gly Phe Thr Ala His Arg 
            20                  25                  30          


Ile Lys Arg Ala Glu Gly Trp Glu Glu Gly Pro Pro Thr Val Leu Ser 
        35                  40                  45              


Asp Ser Pro Trp Thr Asn Ile Ser Gly Ser Cys Lys Gly Arg Cys Phe 
    50                  55                  60                  


Glu Leu Gln Glu Ala Gly Pro Pro Asp Cys Arg Cys Asp Asn Leu Cys 
65                  70                  75                  80  


Lys Ser Tyr Thr Ser Cys Cys His Asp Phe Asp Glu Leu Cys Leu Lys 
                85                  90                  95      


Thr Ala Arg Gly Trp Glu Cys Thr Lys Asp Arg Cys Gly Glu Val Arg 
            100                 105                 110         


Asn Glu Glu Asn Ala Cys His Cys Ser Glu Asp Cys Leu Ala Arg Gly 
        115                 120                 125             


Asp Cys Cys Thr Asn Tyr Gln Val Val Cys Lys Gly Glu Ser His Trp 
    130                 135                 140                 


Val Asp Asp Asp Cys Glu Glu Ile Lys Ala Ala Glu Cys Pro Ala Gly 
145                 150                 155                 160 


Phe Val Arg Pro Pro Leu Ile Ile Phe Ser Val Asp Gly Phe Arg Ala 
                165                 170                 175     


Ser Tyr Met Lys Lys Gly Ser Lys Val Met Pro Asn Ile Glu Lys Leu 
            180                 185                 190         


Arg Ser Cys Gly Thr His Ser Pro Tyr Met Arg Pro Val Tyr Pro Thr 
        195                 200                 205             


Lys Thr Phe Pro Asn Leu Tyr Thr Leu Ala Thr Gly Leu Tyr Pro Glu 
    210                 215                 220                 


Ser His Gly Ile Val Gly Asn Ser Met Tyr Asp Pro Val Phe Asp Ala 
225                 230                 235                 240 


Thr Phe His Leu Arg Gly Arg Glu Lys Phe Asn His Arg Trp Trp Gly 
                245                 250                 255     


Gly Gln Pro Leu Trp Ile Thr Ala Thr Lys Gln Gly Val Lys Ala Gly 
            260                 265                 270         


Thr Phe Phe Trp Ser Val Val Ile Pro His Glu Arg Arg Ile Leu Thr 
        275                 280                 285             


Ile Leu Gln Trp Leu Thr Leu Pro Asp His Glu Arg Pro Ser Val Tyr 
    290                 295                 300                 


Ala Phe Tyr Ser Glu Gln Pro Asp Phe Ser Gly His Lys Tyr Gly Pro 
305                 310                 315                 320 


Phe Gly Pro Glu Glu Ser Ser Tyr Gly Ser Pro Phe Thr Pro Ala Lys 
                325                 330                 335     


Arg Pro Lys Arg Lys Val Ala Pro Lys Arg Arg Gln Glu Arg Pro Val 
            340                 345                 350         


Ala Pro Pro Lys Lys Arg Arg Arg Lys Ile His Arg Met Asp His Tyr 
        355                 360                 365             


Ala Ala Glu Thr Arg Gln Asp Lys Met Thr Asn Pro Leu Arg Glu Ile 
    370                 375                 380                 


Asp Lys Ile Val Gly Gln Leu Met Asp Gly Leu Lys Gln Leu Lys Leu 
385                 390                 395                 400 


His Arg Cys Val Asn Val Ile Phe Val Gly Asp His Gly Met Glu Asp 
                405                 410                 415     


Val Thr Cys Asp Arg Thr Glu Phe Leu Ser Asn Tyr Leu Thr Asn Val 
            420                 425                 430         


Asp Asp Ile Thr Leu Val Pro Gly Thr Leu Gly Arg Ile Arg Ser Lys 
        435                 440                 445             


Phe Ser Asn Asn Ala Lys Tyr Asp Pro Lys Ala Ile Ile Ala Asn Leu 
    450                 455                 460                 


Thr Cys Lys Lys Pro Asp Gln His Phe Lys Pro Tyr Leu Lys Gln His 
465                 470                 475                 480 


Leu Pro Lys Arg Leu His Tyr Ala Asn Asn Arg Arg Ile Glu Asp Ile 
                485                 490                 495     


His Leu Leu Val Glu Arg Arg Trp His Val Ala Arg Lys Pro Leu Asp 
            500                 505                 510         


Val Tyr Lys Lys Pro Ser Gly Lys Cys Phe Phe Gln Gly Asp His Gly 
        515                 520                 525             


Phe Asp Asn Lys Val Asn Ser Met Gln Thr Val Phe Val Gly Tyr Gly 
    530                 535                 540                 


Ser Thr Phe Lys Tyr Lys Thr Lys Val Pro Pro Phe Glu Asn Ile Glu 
545                 550                 555                 560 


Leu Tyr Asn Val Met Cys Asp Leu Leu Gly Leu Lys Pro Ala Pro Asn 
                565                 570                 575     


Asn Gly Thr His Gly Ser Leu Asn His Leu Leu Arg Thr Asn Thr Phe 
            580                 585                 590         


Arg Pro Thr Met Pro Glu Glu Val Thr Arg Pro Asn Tyr Pro Gly Ile 
        595                 600                 605             


Met Tyr Leu Gln Ser Asp Phe Asp Leu Gly Cys Thr Cys Asp Asp Lys 
    610                 615                 620                 


Val Glu Pro Lys Asn Lys Leu Asp Glu Leu Asn Lys Arg Leu His Thr 
625                 630                 635                 640 


Lys Gly Ser Thr Glu Glu Arg His Leu Leu Tyr Gly Arg Pro Ala Val 
                645                 650                 655     


Leu Tyr Arg Thr Arg Tyr Asp Ile Leu Tyr His Thr Asp Phe Glu Ser 
            660                 665                 670         


Gly Tyr Ser Glu Ile Phe Leu Met Pro Leu Trp Thr Ser Tyr Thr Val 
        675                 680                 685             


Ser Lys Gln Ala Glu Val Ser Ser Val Pro Asp His Leu Thr Ser Cys 
    690                 695                 700                 


Val Arg Pro Asp Val Arg Val Ser Pro Ser Phe Ser Gln Asn Cys Leu 
705                 710                 715                 720 


Ala Tyr Lys Asn Asp Lys Gln Met Ser Tyr Gly Phe Leu Phe Pro Pro 
                725                 730                 735     


Tyr Leu Ser Ser Ser Pro Glu Ala Lys Tyr Asp Ala Phe Leu Val Thr 
            740                 745                 750         


Asn Met Val Pro Met Tyr Pro Ala Phe Lys Arg Val Trp Asn Tyr Phe 
        755                 760                 765             


Gln Arg Val Leu Val Lys Lys Tyr Ala Ser Glu Arg Asn Gly Val Asn 
    770                 775                 780                 


Val Ile Ser Gly Pro Ile Phe Asp Tyr Asp Tyr Asp Gly Leu His Asp 
785                 790                 795                 800 


Thr Glu Asp Lys Ile Lys Gln Tyr Val Glu Gly Ser Ser Ile Pro Val 
                805                 810                 815     


Pro Thr His Tyr Tyr Ser Ile Ile Thr Ser Cys Leu Asp Phe Thr Gln 
            820                 825                 830         


Pro Ala Asp Lys Cys Asp Gly Pro Leu Ser Val Ser Ser Phe Ile Leu 
        835                 840                 845             


Pro His Arg Pro Asp Asn Glu Glu Ser Cys Asn Ser Ser Glu Asp Glu 
    850                 855                 860                 


Ser Lys Trp Val Glu Glu Leu Met Lys Met His Thr Ala Arg Val Arg 
865                 870                 875                 880 


Asp Ile Glu His Leu Thr Ser Leu Asp Phe Phe Arg Lys Thr Ser Arg 
                885                 890                 895     


Ser Tyr Pro Glu Ile Leu Thr Leu Lys Thr Tyr Leu His Thr Tyr Glu 
            900                 905                 910         


Ser Glu Ile 
        915 


<210>  13
<211>  888
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (599)..(599)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (602)..(602)
<223>  Xaa can be any naturally occurring amino acid

<400>  13

Met Ala Arg Arg Ser Ser Phe Gln Ser Cys Gln Ile Ile Ser Leu Phe 
1               5                   10                  15      


Thr Phe Ala Val Gly Val Asn Ile Cys Leu Gly Phe Thr Ala His Arg 
            20                  25                  30          


Ile Lys Arg Ala Glu Gly Trp Glu Glu Gly Pro Pro Thr Val Leu Ser 
        35                  40                  45              


Asp Ser Pro Trp Thr Asn Ile Ser Gly Ser Cys Lys Gly Arg Cys Phe 
    50                  55                  60                  


Glu Leu Gln Glu Ala Gly Pro Pro Asp Cys Arg Cys Asp Asn Leu Cys 
65                  70                  75                  80  


Lys Ser Tyr Thr Ser Cys Cys His Asp Phe Asp Glu Leu Cys Leu Lys 
                85                  90                  95      


Thr Ala Arg Gly Trp Glu Cys Thr Lys Asp Arg Cys Gly Glu Val Arg 
            100                 105                 110         


Asn Glu Glu Asn Ala Cys His Cys Ser Glu Asp Cys Leu Ala Arg Gly 
        115                 120                 125             


Asp Cys Cys Thr Asn Tyr Gln Val Val Cys Lys Gly Glu Ser His Trp 
    130                 135                 140                 


Val Asp Asp Asp Cys Glu Glu Ile Lys Ala Ala Glu Cys Pro Ala Gly 
145                 150                 155                 160 


Phe Val Arg Pro Pro Leu Ile Ile Phe Ser Val Asp Gly Phe Arg Ala 
                165                 170                 175     


Ser Tyr Met Lys Lys Gly Ser Lys Val Met Pro Asn Ile Glu Lys Leu 
            180                 185                 190         


Arg Ser Cys Gly Thr His Ser Pro Tyr Met Arg Pro Val Tyr Pro Thr 
        195                 200                 205             


Lys Thr Phe Pro Asn Leu Tyr Thr Leu Ala Thr Gly Leu Tyr Pro Glu 
    210                 215                 220                 


Ser His Gly Ile Val Gly Asn Ser Met Tyr Asp Pro Val Phe Asp Ala 
225                 230                 235                 240 


Thr Phe His Leu Arg Gly Arg Glu Lys Phe Asn His Arg Trp Trp Gly 
                245                 250                 255     


Gly Gln Pro Leu Trp Ile Thr Ala Thr Lys Gln Gly Val Lys Ala Gly 
            260                 265                 270         


Thr Phe Phe Trp Ser Val Val Ile Pro His Glu Arg Arg Ile Leu Thr 
        275                 280                 285             


Ile Leu Gln Trp Leu Thr Leu Pro Asp His Glu Arg Pro Ser Val Tyr 
    290                 295                 300                 


Ala Phe Tyr Ser Glu Gln Pro Asp Phe Ser Gly His Lys Tyr Gly Pro 
305                 310                 315                 320 


Phe Gly Pro Glu Met Thr Asn Pro Leu Arg Glu Ile Asp Lys Ile Val 
                325                 330                 335     


Gly Gln Leu Met Asp Gly Leu Lys Gln Leu Lys Leu His Arg Cys Val 
            340                 345                 350         


Asn Val Ile Phe Val Gly Asp His Gly Met Glu Asp Val Thr Cys Asp 
        355                 360                 365             


Arg Thr Glu Phe Leu Ser Asn Tyr Leu Thr Asn Val Asp Asp Ile Thr 
    370                 375                 380                 


Leu Val Pro Gly Thr Leu Gly Arg Ile Arg Ser Lys Phe Ser Asn Asn 
385                 390                 395                 400 


Ala Lys Tyr Asp Pro Lys Ala Ile Ile Ala Asn Leu Thr Cys Lys Lys 
                405                 410                 415     


Pro Asp Gln His Phe Lys Pro Tyr Leu Lys Gln His Leu Pro Lys Arg 
            420                 425                 430         


Leu His Tyr Ala Asn Asn Arg Arg Ile Glu Asp Ile His Leu Leu Val 
        435                 440                 445             


Glu Arg Arg Trp His Val Ala Arg Lys Pro Leu Asp Val Tyr Lys Lys 
    450                 455                 460                 


Pro Ser Gly Lys Cys Phe Phe Gln Gly Asp His Gly Phe Asp Asn Lys 
465                 470                 475                 480 


Val Asn Ser Met Gln Thr Val Phe Val Gly Tyr Gly Ser Thr Phe Lys 
                485                 490                 495     


Tyr Lys Thr Lys Val Pro Pro Phe Glu Asn Ile Glu Leu Tyr Asn Val 
            500                 505                 510         


Met Cys Asp Leu Leu Gly Leu Lys Pro Ala Pro Asn Asn Gly Thr His 
        515                 520                 525             


Gly Ser Leu Asn His Leu Leu Arg Thr Asn Thr Phe Arg Pro Thr Met 
    530                 535                 540                 


Pro Glu Glu Val Thr Arg Pro Asn Tyr Pro Gly Ile Met Tyr Leu Gln 
545                 550                 555                 560 


Ser Asp Phe Asp Leu Gly Cys Thr Cys Asp Asp Lys Val Glu Pro Lys 
                565                 570                 575     


Asn Lys Leu Asp Glu Leu Asn Lys Arg Leu His Thr Lys Gly Ser Thr 
            580                 585                 590         


Glu Ala Glu Thr Arg Lys Xaa Arg Gly Xaa Arg Asn Glu Asn Lys Glu 
        595                 600                 605             


Asn Ile Asn Gly Asn Phe Glu Pro Arg Lys Glu Arg His Leu Leu Tyr 
    610                 615                 620                 


Gly Arg Pro Ala Val Leu Tyr Arg Thr Arg Tyr Asp Ile Leu Tyr His 
625                 630                 635                 640 


Thr Asp Phe Glu Ser Gly Tyr Ser Glu Ile Phe Leu Met Pro Leu Trp 
                645                 650                 655     


Thr Ser Tyr Thr Val Ser Lys Gln Ala Glu Val Ser Ser Val Pro Asp 
            660                 665                 670         


His Leu Thr Ser Cys Val Arg Pro Asp Val Arg Val Ser Pro Ser Phe 
        675                 680                 685             


Ser Gln Asn Cys Leu Ala Tyr Lys Asn Asp Lys Gln Met Ser Tyr Gly 
    690                 695                 700                 


Phe Leu Phe Pro Pro Tyr Leu Ser Ser Ser Pro Glu Ala Lys Tyr Asp 
705                 710                 715                 720 


Ala Phe Leu Val Thr Asn Met Val Pro Met Tyr Pro Ala Phe Lys Arg 
                725                 730                 735     


Val Trp Asn Tyr Phe Gln Arg Val Leu Val Lys Lys Tyr Ala Ser Glu 
            740                 745                 750         


Arg Asn Gly Val Asn Val Ile Ser Gly Pro Ile Phe Asp Tyr Asp Tyr 
        755                 760                 765             


Asp Gly Leu His Asp Thr Glu Asp Lys Ile Lys Gln Tyr Val Glu Gly 
    770                 775                 780                 


Ser Ser Ile Pro Val Pro Thr His Tyr Tyr Ser Ile Ile Thr Ser Cys 
785                 790                 795                 800 


Leu Asp Phe Thr Gln Pro Ala Asp Lys Cys Asp Gly Pro Leu Ser Val 
                805                 810                 815     


Ser Ser Phe Ile Leu Pro His Arg Pro Asp Asn Glu Glu Ser Cys Asn 
            820                 825                 830         


Ser Ser Glu Asp Glu Ser Lys Trp Val Glu Glu Leu Met Lys Met His 
        835                 840                 845             


Thr Ala Arg Val Arg Asp Ile Glu His Leu Thr Ser Leu Asp Phe Phe 
    850                 855                 860                 


Arg Lys Thr Ser Arg Ser Tyr Pro Glu Ile Leu Thr Leu Lys Thr Tyr 
865                 870                 875                 880 


Leu His Thr Tyr Glu Ser Glu Ile 
                885             


<210>  14
<211>  862
<212>  PRT
<213>  Mus spps

<400>  14

Met Ala Arg Gln Gly Cys Phe Gly Ser Tyr Gln Val Ile Ser Leu Phe 
1               5                   10                  15      


Thr Phe Ala Ile Gly Val Asn Leu Cys Leu Gly Phe Thr Ala Ser Arg 
            20                  25                  30          


Ile Lys Arg Ala Glu Trp Asp Glu Gly Pro Pro Thr Val Leu Ser Asp 
        35                  40                  45              


Ser Pro Trp Thr Asn Thr Ser Gly Ser Cys Lys Gly Arg Cys Phe Glu 
    50                  55                  60                  


Leu Gln Glu Val Gly Pro Pro Asp Cys Arg Cys Asp Asn Leu Cys Lys 
65                  70                  75                  80  


Ser Tyr Ser Ser Cys Cys His Asp Phe Asp Glu Leu Cys Leu Lys Thr 
                85                  90                  95      


Ala Arg Gly Trp Glu Cys Thr Lys Asp Arg Cys Gly Glu Val Arg Asn 
            100                 105                 110         


Glu Glu Asn Ala Cys His Cys Ser Glu Asp Cys Leu Ser Arg Gly Asp 
        115                 120                 125             


Cys Cys Thr Asn Tyr Gln Val Val Cys Lys Gly Glu Ser His Trp Val 
    130                 135                 140                 


Asp Asp Asp Cys Glu Glu Ile Arg Val Pro Glu Cys Pro Ala Gly Phe 
145                 150                 155                 160 


Val Arg Pro Pro Leu Ile Ile Phe Ser Val Asp Gly Phe Arg Ala Ser 
                165                 170                 175     


Tyr Met Lys Lys Gly Ser Lys Val Met Pro Asn Ile Glu Lys Leu Arg 
            180                 185                 190         


Ser Cys Gly Thr His Ala Pro Tyr Met Arg Pro Val Tyr Pro Thr Lys 
        195                 200                 205             


Thr Phe Pro Asn Leu Tyr Thr Leu Ala Thr Gly Leu Tyr Pro Glu Ser 
    210                 215                 220                 


His Gly Ile Val Gly Asn Ser Met Tyr Asp Pro Val Phe Asp Ala Thr 
225                 230                 235                 240 


Phe His Leu Arg Gly Arg Glu Lys Phe Asn His Arg Trp Trp Gly Gly 
                245                 250                 255     


Gln Pro Leu Trp Ile Thr Ala Thr Lys Gln Gly Val Arg Ala Gly Thr 
            260                 265                 270         


Phe Phe Trp Ser Val Ser Ile Pro His Glu Arg Arg Ile Leu Thr Ile 
        275                 280                 285             


Leu Gln Trp Leu Ser Leu Pro Asp Asn Glu Arg Pro Ser Val Tyr Ala 
    290                 295                 300                 


Phe Tyr Ser Glu Gln Pro Asp Phe Ser Gly His Lys Tyr Gly Pro Phe 
305                 310                 315                 320 


Gly Pro Glu Met Thr Asn Pro Leu Arg Glu Ile Asp Lys Thr Val Gly 
                325                 330                 335     


Gln Leu Met Asp Gly Leu Lys Gln Leu Lys Leu His Arg Cys Val Asn 
            340                 345                 350         


Val Ile Phe Val Gly Asp His Gly Met Glu Asp Val Thr Cys Asp Arg 
        355                 360                 365             


Thr Glu Phe Leu Ser Asn Tyr Leu Thr Asn Val Asp Asp Ile Thr Leu 
    370                 375                 380                 


Val Pro Gly Thr Leu Gly Arg Ile Arg Pro Lys Ile Pro Asn Asn Leu 
385                 390                 395                 400 


Lys Tyr Asp Pro Lys Ala Ile Ile Ala Asn Leu Thr Cys Lys Lys Pro 
                405                 410                 415     


Asp Gln His Phe Lys Pro Tyr Met Lys Gln His Leu Pro Lys Arg Leu 
            420                 425                 430         


His Tyr Ala Asn Asn Arg Arg Ile Glu Asp Leu His Leu Leu Val Glu 
        435                 440                 445             


Arg Arg Trp His Val Ala Arg Lys Pro Leu Asp Val Tyr Lys Lys Pro 
    450                 455                 460                 


Ser Gly Lys Cys Phe Phe Gln Gly Asp His Gly Phe Asp Asn Lys Val 
465                 470                 475                 480 


Asn Ser Met Gln Thr Val Phe Val Gly Tyr Gly Pro Thr Phe Lys Tyr 
                485                 490                 495     


Arg Thr Lys Val Pro Pro Phe Glu Asn Ile Glu Leu Tyr Asn Val Met 
            500                 505                 510         


Cys Asp Leu Leu Gly Leu Lys Pro Ala Pro Asn Asn Gly Thr His Gly 
        515                 520                 525             


Ser Leu Asn His Leu Leu Arg Thr Asn Thr Phe Arg Pro Thr Leu Pro 
    530                 535                 540                 


Glu Glu Val Ser Arg Pro Asn Tyr Pro Gly Ile Met Tyr Leu Gln Ser 
545                 550                 555                 560 


Asp Phe Asp Leu Gly Cys Thr Cys Asp Asp Lys Val Glu Pro Lys Asn 
                565                 570                 575     


Lys Leu Glu Glu Leu Asn Lys Arg Leu His Thr Lys Gly Ser Thr Glu 
            580                 585                 590         


Glu Arg His Leu Leu Tyr Gly Arg Pro Ala Val Leu Tyr Arg Thr Ser 
        595                 600                 605             


Tyr Asp Ile Leu Tyr His Thr Asp Phe Glu Ser Gly Tyr Ser Glu Ile 
    610                 615                 620                 


Phe Leu Met Pro Leu Trp Thr Ser Tyr Thr Ile Ser Lys Gln Ala Glu 
625                 630                 635                 640 


Val Ser Ser Ile Pro Glu His Leu Thr Asn Cys Val Arg Pro Asp Val 
                645                 650                 655     


Arg Val Ser Pro Gly Phe Ser Gln Asn Cys Leu Ala Tyr Lys Asn Asp 
            660                 665                 670         


Lys Gln Met Ser Tyr Gly Phe Leu Phe Pro Pro Tyr Leu Ser Ser Ser 
        675                 680                 685             


Pro Glu Ala Lys Tyr Asp Ala Phe Leu Val Thr Asn Met Val Pro Met 
    690                 695                 700                 


Tyr Pro Ala Phe Lys Arg Val Trp Thr Tyr Phe Gln Arg Val Leu Val 
705                 710                 715                 720 


Lys Lys Tyr Ala Ser Glu Arg Asn Gly Val Asn Val Ile Ser Gly Pro 
                725                 730                 735     


Ile Phe Asp Tyr Asn Tyr Asn Gly Leu Arg Asp Ile Glu Asp Glu Ile 
            740                 745                 750         


Lys Gln Tyr Val Glu Gly Ser Ser Ile Pro Val Pro Thr His Tyr Tyr 
        755                 760                 765             


Ser Ile Ile Thr Ser Cys Leu Asp Phe Thr Gln Pro Ala Asp Lys Cys 
    770                 775                 780                 


Asp Gly Pro Leu Ser Val Ser Ser Phe Ile Leu Pro His Arg Pro Asp 
785                 790                 795                 800 


Asn Asp Glu Ser Cys Asn Ser Ser Glu Asp Glu Ser Lys Trp Val Glu 
                805                 810                 815     


Glu Leu Met Lys Met His Thr Ala Arg Val Arg Asp Ile Glu His Leu 
            820                 825                 830         


Thr Gly Leu Asp Phe Tyr Arg Lys Thr Ser Arg Ser Tyr Ser Glu Ile 
        835                 840                 845             


Leu Thr Leu Lys Thr Tyr Leu His Thr Tyr Glu Ser Glu Ile 
    850                 855                 860         


<210>  15
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polymer for binding metal ions

<400>  15

Gly Ser His His His His His His 
1               5               


<210>  16
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  16

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Trp Ser Glu Ala Leu Tyr Val Val Phe Asp Tyr 
            100                 105                 110 


<210>  17
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  17

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ala Asn Phe 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Phe Ser Ala Pro Phe 
                85                  90                  95      


Thr 
    


<210>  18
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  18

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Ala Asp Phe Trp Tyr Phe Asp Tyr 
            100                 105             


<210>  19
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  19

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asp Val Trp 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr 
    


<210>  20
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  20

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Tyr Gly Thr Phe Asp Tyr 
            100                 105 


<210>  21
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  21

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ala Asp Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Asn Gly Trp Pro Arg 
                85                  90                  95      


Thr 
    


<210>  22
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  22

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Asp Leu Pro Leu Gly Arg Leu Asp Tyr 
            100                 105             


<210>  23
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  23

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asn Lys His 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Arg Ala Pro Tyr 
                85                  90                  95      


Thr 
    


<210>  24
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  24

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Tyr Ile Tyr Gly Asp Leu Asp Tyr 
            100                 105             


<210>  25
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  25

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ala Lys Phe 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Asn Ser Ala Pro Ile 
                85                  90                  95      


Thr Phe 
        


<210>  26
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  26

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Ile Gly Thr Gly Tyr Tyr Gly Phe Phe Asp Tyr 
            100                 105                 110 


<210>  27
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  27

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Gly Trp 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Thr Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Tyr Pro Ile 
                85                  90                  95      


Thr 
    


<210>  28
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  28

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Ser Ala Tyr Gly Asp Phe Asp Tyr 
            100                 105             


<210>  29
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  29

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ala Lys Trp 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Phe Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr 
    


<210>  30
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  30

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ser Pro Tyr Phe Gly Asn Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Gly Asp Phe Gly Gly Asn Val Phe Thr Glu Phe Asp Tyr 
            100                 105                 110         


<210>  31
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  31

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asp Gly Trp 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr 
    


<210>  32
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  32

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Ala Arg Tyr Ala Arg Gly Tyr Met His Thr Phe Asp Tyr 
            100                 105                 110         


<210>  33
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  33

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asn Asn Ser 
            20                  25                  30          


Asp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Thr Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ala Thr Thr Val Pro 
                85                  90                  95      


Leu Thr 
        


<210>  34
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  34

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Asp Leu Pro Leu Gly Met Leu Asp Tyr 
            100                 105             


<210>  35
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  35

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Leu Ser Ile Pro Ile 
                85                  90                  95      


Thr 
    


<210>  36
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  36

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Tyr Tyr Phe Thr Val Leu Asp Tyr 
            100                 105             


<210>  37
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  37

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Thr Ala Phe Pro 
                85                  90                  95      


Leu Thr 
        


<210>  38
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  38

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Phe Ser Val Tyr Gly Asp Phe Asp Tyr 
            100                 105             


<210>  39
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  39

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ala Thr Ala Phe Pro 
                85                  90                  95      


Leu Thr 
        


<210>  40
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  40

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ile Ser Gly Tyr Gly Asp Leu Asp Tyr 
            100                 105             


<210>  41
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  41

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ala Lys Trp 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr 
    


<210>  42
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  42

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asn Ala Trp Glu Gly Ala Met Leu Asp Tyr 
            100                 105             


<210>  43
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  43

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile His Asn Trp 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr 
    


<210>  44
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  44

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Asn Ser Asp Gly Ser Ser Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Leu Glu Ala Ile Asp Tyr Ala Trp Gly Phe Asp Tyr 
            100                 105                 110 


<210>  45
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  45

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ala Asp Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Phe His Trp Pro Leu 
                85                  90                  95      


Thr 
    


<210>  46
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  46

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Val Lys Gly Ser Ala Thr Leu Asp Tyr 
            100                 105             


<210>  47
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  47

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ala Asn Trp 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr 
    


<210>  48
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  48

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ala Ser Thr Tyr Gly Asp Leu Asp Tyr 
            100                 105             


<210>  49
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  49

Ser Tyr Ala Ile Ser 
1               5   


<210>  50
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  50

Ser Tyr Gly Ile Ser 
1               5   


<210>  51
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  51

Ser Tyr Ala Met Ser 
1               5   


<210>  52
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  52

Ser Tyr Trp Ile Gly 
1               5   


<210>  53
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  53

Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  54
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  54

Gly Ile Ile Pro Ile Phe Gly Asn Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  55
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  55

Gly Ile Ser Pro Tyr Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  56
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  56

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  57
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  57

Val Ile Asn Ser Asp Gly Ser Ser Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  58
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  58

Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  59
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  59

Gly Ile Ile Pro Ile Phe Gly Asn Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  60
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  60

Gly Ile Ile Pro Ile Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  61
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  61

Asp Leu Tyr Ile Tyr Gly Asp Leu Asp Tyr 
1               5                   10  


<210>  62
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  62

Asp Ser Ser Ala Tyr Gly Asp Phe Asp Tyr 
1               5                   10  


<210>  63
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  63

Asp Ala Ser Thr Tyr Gly Asp Leu Asp Tyr 
1               5                   10  


<210>  64
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  64

Asp Ile Ser Gly Tyr Gly Asp Leu Asp Tyr 
1               5                   10  


<210>  65
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  65

Asp Phe Ser Val Tyr Gly Asp Phe Asp Tyr 
1               5                   10  


<210>  66
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  66

Pro Ile Gly Thr Gly Tyr Tyr Gly Phe Phe Asp Tyr 
1               5                   10          


<210>  67
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  67

Tyr Gly Asp Phe Gly Gly Asn Val Phe Thr Glu Phe Asp Tyr 
1               5                   10                  


<210>  68
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  68

Ile Ala Arg Tyr Ala Arg Gly Tyr Met His Thr Phe Asp Tyr 
1               5                   10                  


<210>  69
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  69

Asp Asp Leu Pro Leu Gly Arg Leu Asp Tyr 
1               5                   10  


<210>  70
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  70

Asp Asp Leu Pro Leu Gly Met Leu Asp Tyr 
1               5                   10  


<210>  71
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  71

Asp Arg Tyr Tyr Phe Thr Val Leu Asp Tyr 
1               5                   10  


<210>  72
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  72

Lys Asn Ala Trp Glu Gly Ala Met Leu Asp Tyr 
1               5                   10      


<210>  73
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  73

Lys Asp Val Lys Gly Ser Ala Thr Leu Asp Tyr 
1               5                   10      


<210>  74
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  74

Lys Leu Glu Ala Ile Asp Tyr Ala Trp Gly Phe Asp Tyr 
1               5                   10              


<210>  75
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  75

Gly Leu Ala Asp Phe Trp Tyr Phe Asp Tyr 
1               5                   10  


<210>  76
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  76

Pro Tyr Gly Thr Phe Asp Tyr 
1               5           


<210>  77
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  77

Asn Trp Ser Glu Ala Leu Tyr Val Val Phe Asp Tyr 
1               5                   10          


<210>  78
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  78

Asp Asp Val Ala Leu Gly Arg Leu Asp Tyr 
1               5                   10  


<210>  79
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  79

Ser Asp Leu Asn Asn Val Ser Thr Val Leu Asp Tyr 
1               5                   10          


<210>  80
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  80

Ala Asp Ala Asn Gln Leu Ser Gly Tyr Leu Asp Tyr 
1               5                   10          


<210>  81
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  81

Glu Asp Val Ala Leu Gly Arg Leu Asp Tyr 
1               5                   10  


<210>  82
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  82

His Asp Val Asn Ser Leu Trp Ala Tyr Phe Asp Tyr 
1               5                   10          


<210>  83
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  83

Gly Asp Tyr Asn Ala Ile Tyr Tyr Ala Leu Asp Tyr 
1               5                   10          


<210>  84
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  84

Asp Asp Leu Ala Leu Gly Arg Leu Asp Tyr 
1               5                   10  


<210>  85
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  85

Asp Asp Asp Val Asn Ser Leu Ala Ser Tyr Pro Leu Asp Tyr 
1               5                   10                  


<210>  86
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  86

Asp Gly Asp Val Asn Ser Val Tyr Ser Ser Gly Leu Asp Tyr 
1               5                   10                  


<210>  87
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  87

Gly Asp Ala Asn Ala Leu Tyr Asp Tyr Phe Asp Tyr 
1               5                   10          


<210>  88
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  88

Asp Asp Trp Leu Ser His Phe Asp Tyr 
1               5                   


<210>  89
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  89

Arg Asp Gly Asn Tyr Leu His Val Asp His Phe Asp Tyr 
1               5                   10              


<210>  90
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  90

Asp His Gly Tyr Ala Tyr Tyr Ser Ala Phe Asp Tyr 
1               5                   10          


<210>  91
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  91

Asp Phe Leu Ser Gln Phe Ser Trp Leu Asp Tyr 
1               5                   10      


<210>  92
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  92

Asp Gly Val Thr Thr Tyr Asp Tyr Phe Asp Tyr 
1               5                   10      


<210>  93
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  93

His Tyr Leu Pro Asp Ala Thr Leu Asp Tyr 
1               5                   10  


<210>  94
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  94

Gly Thr Phe Thr Tyr Asp Phe Leu Asp Tyr 
1               5                   10  


<210>  95
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  95

Gly Phe Val Asn Phe Ser Arg Leu Asp Tyr 
1               5                   10  


<210>  96
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  96

Asp Trp Trp Val Thr Asp Ile Leu Asp Tyr 
1               5                   10  


<210>  97
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  97

Gly Glu Ala Asn Glu Val Tyr Pro Gly Leu Asp Tyr 
1               5                   10          


<210>  98
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  98

Asp Leu Tyr Gly Ile Asp Ile Tyr Tyr Ala Leu Asp Tyr 
1               5                   10              


<210>  99
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  99

Asp Thr Phe Trp Phe Thr Val Phe Asp Tyr 
1               5                   10  


<210>  100
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  100

Gly Asp Ala Asn Ser Ile Tyr Pro Leu Phe Asp Tyr 
1               5                   10          


<210>  101
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  101

Gly Ala Asp Ser Asn Ala Val Arg Leu Val Gly Phe Asp Tyr 
1               5                   10                  


<210>  102
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  102

Glu Asp Val Asn Tyr Ile Ser Thr Tyr Ser Glu Phe Asp Tyr 
1               5                   10                  


<210>  103
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  103

Gly Asp Asp Asn Glu Val Ile Tyr His Leu Asp Tyr 
1               5                   10          


<210>  104
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  104

Arg Ala Ser Gln Ser Ile Gly Gly Trp Leu Asn 
1               5                   10      


<210>  105
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  105

Arg Ala Ser Gln Ser Ile Asp Gly Trp Leu Asn 
1               5                   10      


<210>  106
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  106

Arg Ala Ser Gln Ser Ile Ala Lys Trp Leu Asn 
1               5                   10      


<210>  107
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  107

Arg Ala Ser Gln Ser Val Asn Asn Ser Asp Leu Ala 
1               5                   10          


<210>  108
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  108

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  109
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  109

Arg Ala Ser Gln Ser Val Asn Lys His Leu Ala 
1               5                   10      


<210>  110
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  110

Arg Ala Ser Gln Ser Val Ala Lys Phe Leu Ala 
1               5                   10      


<210>  111
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  111

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  112
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  112

Arg Ala Ser Gln Ser Ile His Asn Trp Leu Asn 
1               5                   10      


<210>  113
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  113

Arg Ala Ser Gln Ser Ile Ala Asn Trp Leu Asn 
1               5                   10      


<210>  114
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  114

Arg Ala Ser Gln Ser Val Ala Asp Ser Leu Ala 
1               5                   10      


<210>  115
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  115

Arg Ala Ser Gln Ser Ile Asp Val Trp Leu Asn 
1               5                   10      


<210>  116
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  116

Arg Ala Ser Gln Ser Val Ala Asn Phe Leu Ala 
1               5                   10      


<210>  117
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  117

Arg Ala Ser Gln Ser Ile Gly Lys Val Leu Asn 
1               5                   10      


<210>  118
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  118

Arg Ala Ser Gln Ser Ile Gly Arg Ser Leu Asn 
1               5                   10      


<210>  119
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  119

Arg Ala Ser Gln Ser Val Ser Lys Ala Leu Ala 
1               5                   10      


<210>  120
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  120

Arg Ala Ser Gln Ser Val Ser Ser Phe Leu Ala 
1               5                   10      


<210>  121
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  121

Arg Ala Ser Gln Ser Val Asn Ser Trp Leu Ala 
1               5                   10      


<210>  122
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  122

Arg Ala Ser Gln Ser Val Ala Asp Phe Leu Ala 
1               5                   10      


<210>  123
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  123

Arg Ala Ser Gln Ser Val Ser Asp Tyr Leu Ala 
1               5                   10      


<210>  124
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  124

Arg Ala Ser Gln Ser Val Asn Lys Phe Leu Ala 
1               5                   10      


<210>  125
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  125

Arg Ala Ser Gln Ser Val Arg Asp Trp Leu Ala 
1               5                   10      


<210>  126
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  126

Arg Ala Ser Gln Ser Val Arg Lys Tyr Leu Ala 
1               5                   10      


<210>  127
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  127

Arg Ala Ser Gln Ser Val Arg Asn Phe Leu Ala 
1               5                   10      


<210>  128
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  128

Arg Ala Ser Gln Ser Val Ser Asn Trp Leu Ala 
1               5                   10      


<210>  129
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  129

Arg Ala Ser Gln Ser Val Asn Asn Phe Leu Ala 
1               5                   10      


<210>  130
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  130

Arg Ala Ser Gln Ser Val Ala Asp Trp Leu Ala 
1               5                   10      


<210>  131
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  131

Arg Ala Ser Gln Ser Val Ser Ser Trp Leu Ala 
1               5                   10      


<210>  132
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  132

Arg Ala Ser Gln Ser Val Ala Asp Tyr Leu Ala 
1               5                   10      


<210>  133
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  133

Arg Ala Ser Gln Ser Val Ala Lys Asp Leu Ala 
1               5                   10      


<210>  134
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  134

Arg Ala Ser Gln Ser Val Ala Ser Ala Leu Ala 
1               5                   10      


<210>  135
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  135

Arg Ala Ser Gln Ser Val Ser Lys Ser Ala Leu Ala 
1               5                   10          


<210>  136
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  136

Arg Ala Ser Gln Ser Val Ala Tyr Ser Ser Leu Ala 
1               5                   10          


<210>  137
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  137

Arg Ala Ser Gln Ser Val Arg Lys Ser Gly Leu Ala 
1               5                   10          


<210>  138
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  138

Arg Ala Ser Gln Ser Val Ala Lys Ser Asp Leu Ala 
1               5                   10          


<210>  139
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  139

Thr Ala Ser Ser Leu Gln Ser 
1               5           


<210>  140
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  140

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  141
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  141

Phe Ala Ser Ser Leu Gln Ser 
1               5           


<210>  142
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  142

Thr Ala Ser Ser Arg Ala Thr 
1               5           


<210>  143
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  143

Lys Ala Ser Asn Arg Ala Thr 
1               5           


<210>  144
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  144

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  145
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  145

Asn Ala Ser Asn Arg Ala Thr 
1               5           


<210>  146
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  146

Tyr Ala Ser Asn Arg Ala Thr 
1               5           


<210>  147
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  147

Gly Ala Ser Ser Leu Gln Ser 
1               5           


<210>  148
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  148

Lys Ala Ser Ser Leu Gln Ser 
1               5           


<210>  149
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  149

Thr Ala Ser Asn Arg Ala Thr 
1               5           


<210>  150
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  150

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  151
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  151

Phe Ala Ser Asn Arg Ala Thr 
1               5           


<210>  152
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  152

Gly Ala Ser Asn Arg Ala Thr 
1               5           


<210>  153
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  153

Asn Ala Ser Ser Arg Ala Thr 
1               5           


<210>  154
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  154

Ala Ala Ser Ser Arg Ala Thr 
1               5           


<210>  155
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  155

Gln Gln Ser Tyr Thr Tyr Pro Ile Thr 
1               5                   


<210>  156
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  156

Gln Gln Ser Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  157
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  157

Gln Gln Ala Thr Thr Val Pro Leu Thr 
1               5                   


<210>  158
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  158

Gln Gln His Leu Ser Ile Pro Ile Thr 
1               5                   


<210>  159
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  159

Gln Gln Gly Ile Arg Ala Pro Tyr Thr 
1               5                   


<210>  160
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  160

Gln Gln Phe Asn Ser Ala Pro Ile Thr 
1               5                   


<210>  161
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  161

Gln Gln Tyr Thr Ala Phe Pro Leu Thr 
1               5                   


<210>  162
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  162

Gln Gln Ala Thr Ala Phe Pro Leu Thr 
1               5                   


<210>  163
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  163

Gln Gln Ser Phe His Trp Pro Leu Thr 
1               5                   


<210>  164
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  164

Gln Gln Ser Asn Gly Trp Pro Arg Thr 
1               5                   


<210>  165
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  165

Gln Gln Tyr Phe Ser Ala Pro Phe Thr 
1               5                   


<210>  166
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  166

Gln Gln Pro Ile Ser Thr Pro Leu Thr 
1               5                   


<210>  167
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  167

Gln Gln Pro Phe Asp Tyr Pro Phe Thr 
1               5                   


<210>  168
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  168

Gln Gln Pro Ile Ser Phe Pro Tyr Thr 
1               5                   


<210>  169
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  169

Gln Gln Gly His Gly Trp Pro Arg Thr 
1               5                   


<210>  170
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  170

Gln Gln Tyr Lys Asn Ala Pro Arg Thr 
1               5                   


<210>  171
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  171

Gln Gln Ser His Arg Ala Pro Trp Thr 
1               5                   


<210>  172
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  172

Gln Gln Gly His Arg Trp Pro Phe Thr 
1               5                   


<210>  173
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  173

Gln Gln Gly Ser Thr Ala Pro Tyr Thr 
1               5                   


<210>  174
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  174

Gln Gln Gly Ser Asp Ala Pro Leu Thr 
1               5                   


<210>  175
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  175

Gln Gln Tyr Asn His Ala Pro Phe Thr 
1               5                   


<210>  176
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  176

Gln Gln Gly Asp Gly Trp Pro Trp Thr 
1               5                   


<210>  177
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  177

Gln Gln Gly Asp Thr Ala Pro Ile 
1               5               


<210>  178
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  178

Gln Gln Gly Tyr Arg Ala Pro Ile Thr 
1               5                   


<210>  179
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  179

Gln Gln Arg Tyr Thr Ala Pro Trp Thr 
1               5                   


<210>  180
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  180

Gln Gln Phe Lys Gly Ala Pro Leu Thr 
1               5                   


<210>  181
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  181

Gln Gln Ser Phe Arg Trp Pro Leu Thr 
1               5                   


<210>  182
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  182

Gln Gln Phe Lys Gly Trp Pro Phe Thr 
1               5                   


<210>  183
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  183

Gln Gln Tyr Ile Arg Trp Pro Ile Thr 
1               5                   


<210>  184
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  184

Gln Gln Tyr Ile Ser Ala Pro Leu Thr 
1               5                   


<210>  185
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  185

Gln Gln Gly Ile Asn Trp Pro Phe Thr 
1               5                   


<210>  186
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  186

Gln Gln Gly Gly Asn Trp Pro Trp Thr 
1               5                   


<210>  187
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  187

Gln Gln Tyr Ser Thr Trp Pro Phe Thr 
1               5                   


<210>  188
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  188

Gln Gln Ser Ser Arg Asp Pro Trp Thr 
1               5                   


<210>  189
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  189

Gln Gln Ser Ser Gly Phe Pro Leu Thr 
1               5                   


<210>  190
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  190

Gln Gln Ser Ser Arg Tyr Pro Trp Thr 
1               5                   


<210>  191
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  191

Gln Gln Tyr Gly Ser Ser Pro Leu Thr 
1               5                   


<210>  192
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  192

Gln Gln Ser Ser Arg Phe Pro Trp Thr 
1               5                   


<210>  193
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  193

Gln Gln Asp Ser Ala Phe Pro Trp Thr 
1               5                   


<210>  194
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  194

Gln Gln Ser Asn Thr Asn Pro Leu Thr 
1               5                   


<210>  195
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  195

Gln Gln Ser Asn Lys Asp Pro Leu Thr 
1               5                   


<210>  196
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  196

Gln Gln Ser Asn Thr Leu Pro Leu Thr 
1               5                   


<210>  197
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  197

Gln Gln Ser Asn Thr Pro Pro Leu Thr 
1               5                   


<210>  198
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  198

Gln Gln Ala Thr Lys Pro Pro Leu Thr 
1               5                   


<210>  199
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  199

Gln Gln Asp Tyr Gly Tyr Pro Leu Thr 
1               5                   


<210>  200
<211>  108
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MUTAGEN
<222>  (52)..(52)
<223>  May be Ile or Ser

<220>
<221>  MUTAGEN
<222>  (54)..(54)
<223>  May be Ile or Tyr

<220>
<221>  MUTAGEN
<222>  (57)..(57)
<223>  May be Asn or Thr

<220>
<221>  MUTAGEN
<222>  (58)..(58)
<223>  May be  Ala or Thr

<220>
<221>  MUTAGEN
<222>  (105)..(105)
<223>  May be  Asp or Phe

<220>
<221>  MUTAGEN
<222>  (106)..(106)
<223>  May be  Phe or Leu

<400>  200

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Xaa Pro Xaa Phe Gly Xaa Xaa Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Tyr Ile Tyr Gly Xaa Xaa Asp Tyr 
            100                 105             


<210>  201
<211>  97
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MUTAGEN
<222>  (30)..(30)
<223>  X may be Ala, Asp or Gly

<220>
<221>  MUTAGEN
<222>  (31)..(31)
<223>  X may be Gly or Lys

<220>
<221>  MUTAGEN
<222>  (50)..(50)
<223>  X may be Ala or Thr

<220>
<221>  MUTAGEN
<222>  (93)..(93)
<223>  X may be Ser or Thr

<220>
<221>  MUTAGEN
<222>  (94)..(94)
<223>  X may be Thr or Tyr

<220>
<221>  MUTAGEN
<222>  (96)..(96)
<223>  X may be Ile or Leu

<400>  201

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Xaa Xaa Trp 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Xaa Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Xaa Xaa Pro Xaa 
                85                  90                  95      


Thr 
    


<210>  202
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  202

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 


<210>  203
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  203

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 


<210>  204
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  204

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 


<210>  205
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  205

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  206
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  206

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  207
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  207

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  208
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  208

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


