                         SEQUENCE LISTING

<110>  Yeda Research And Development Co. Ltd.
       Tawfik, Dan S.
       Gupta, Rinkoo Devi
       Goldsmith, Moshe
       Ashani, Yaacov
 
<120>  ISOLATED PON1 POLYPEPTIDES, POLYNUCLEOTIDES ENCODING SAME AND 
       USES THEREOF IN TREATING OR PREVENTING ORGANOPHOSPHATE EXPOSURE 
       ASSOCIATED DAMAGE

<130>  55881

<150>  US 13/420,920
<151>  2012-03-15

<160>  142   

<170>  PatentIn version 3.5

<210>  1
<211>  355
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  1

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu 
        355 


<210>  2
<211>  366
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  2

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Gly Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Trp Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn Arg Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Ser Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Ser Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu Ala Ala Ala Leu Glu His His His His His His 
        355                 360                 365     


<210>  3
<211>  366
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  3

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Val Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Leu Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn Arg Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Ser Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Leu Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Ser Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu Ala Ala Ala Leu Glu His His His His His His 
        355                 360                 365     


<210>  4
<211>  366
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  4

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Gly Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Thr Phe 
            100                 105                 110         


Asn Pro Trp Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn Arg Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu Pro Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Ser Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Ser Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu Ala Ala Ala Leu Glu His His His His His His 
        355                 360                 365     


<210>  5
<211>  366
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  5

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Val Lys Phe Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Leu Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn Arg Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Phe His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Ser Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Ser Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu Ala Ala Ala Leu Glu His His His His His His 
        355                 360                 365     


<210>  6
<211>  366
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  6

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Val Lys Phe Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Leu Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn Arg Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Ser Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Ser Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu Ala Ala Ala Leu Glu His His His His His His 
        355                 360                 365     


<210>  7
<211>  366
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  7

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Val Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Val Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn Arg Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Ser Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Ser Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu Ala Ala Ala Leu Glu His His His His His His 
        355                 360                 365     


<210>  8
<211>  366
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  8

Met Ala Lys Leu Thr Ala Leu Thr Leu Ser Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Ser Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Gly Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Trp Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn Arg Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Ser Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Arg Thr Leu 
                245                 250                 255     


Thr Pro Met Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Ser Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu Ala Ala Ala Leu Glu His His His His His His 
        355                 360                 365     


<210>  9
<211>  366
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  9

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Val Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Trp Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn Arg Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Ser Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Ser Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu Ala Ala Ala Leu Glu His His His His His His 
        355                 360                 365     


<210>  10
<211>  366
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  10

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Val Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Leu Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn Asn Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Leu His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Ser Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Ser Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu Ala Ala Ala Leu Glu His His His His His His 
        355                 360                 365     


<210>  11
<211>  366
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  11

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu Ala Ala Ala Leu Glu His His His His His His 
        355                 360                 365     


<210>  12
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  12

Met Ala Lys Leu Thr Glu Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Gly Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Trp Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn Arg Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Ser Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Glu Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Ser Val Leu Gln Gly Ser Ser Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


<210>  13
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  13

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Gly Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Trp Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn Arg Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Cys Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


<210>  14
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  14

Met Ala Lys Pro Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Ala Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Trp Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Ala Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Val His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Ser Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


<210>  15
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  15

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Gly Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Trp Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn Thr Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Leu Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


<210>  16
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  16

Met Ala Lys Leu Thr Thr Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Ala Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Trp Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Ala Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asn Val Arg Val Val Ala Glu Gly Phe Asp Ser Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Ile Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


<210>  17
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  17

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Trp Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Ala Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Ala Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


<210>  18
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  18

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Ser 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Ala Thr Gly Asp Leu Trp Val Gly Cys Arg Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Ser Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


<210>  19
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  19

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Thr Ser Ser Phe 
            100                 105                 110         


Asn Pro Trp Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Pro Asp Ser Ser Pro Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Ala Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


<210>  20
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  20

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Gly Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Trp Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn Arg Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Ser Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Glu Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


<210>  21
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  21

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Ser 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys Arg Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Ser Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


<210>  22
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  22

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asp Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Ser 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys Arg Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Ser Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Ser Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


<210>  23
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  23

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Thr Asp Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys Arg Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Ser Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Ser Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


<210>  24
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  24

Met Ala Lys Leu Thr Ala Leu Thr Leu Ser Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Gly Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Trp Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Ala Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Ser Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


<210>  25
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  25

Met Ala Lys Leu Thr Ala Leu Thr Leu Ser Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Ala Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Trp Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn Arg Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Ser Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


<210>  26
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  26

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Ala Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Trp Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Ala Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Ser Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Ile Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


<210>  27
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  27

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asp Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Pro Ser Phe 
            100                 105                 110         


Asn Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Ser 
225                 230                 235                 240 


Leu Ala Arg Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Leu Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asp Gly Thr Val Leu Gln Gly Ser Ala Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


<210>  28
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  28

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Gly Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Trp Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn Arg Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Val His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Ser Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Ser Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


<210>  29
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  29

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Ser Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Trp Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Ala Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


<210>  30
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  30

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Gly Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Trp Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Leu Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


<210>  31
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  31

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Ser Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Trp Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Ala Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Ser Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


<210>  32
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  32

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Trp Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Ala Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


<210>  33
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  33

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Trp Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Ile His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


<210>  34
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  34

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Trp Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Leu Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Ala Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


<210>  35
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  35

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Trp Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Ile Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Ala Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


<210>  36
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  36

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Trp Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Leu Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Ala Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


<210>  37
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  37

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Trp Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Pro Asp Ser Ser Pro Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Met Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Ala Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


<210>  38
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  38

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Trp Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Ala Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


<210>  39
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  39

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Gly Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Trp Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Ser Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


<210>  40
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  40

Met Ala Lys Leu Thr Ala Leu Thr Leu Ser Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Tyr Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Gly Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Trp Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn Arg Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Ser Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Ser Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


<210>  41
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  41

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Trp Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Val Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


<210>  42
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  42

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Ala Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Trp Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Ala Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Val His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Ser Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Ile Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


<210>  43
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  43

Met Ala Lys Leu Thr Ala Leu Thr Leu Ser Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Ser Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Trp Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Ala Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Ser Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


<210>  44
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  44

Met Ala Lys Leu Thr Ala Leu Thr Leu Ser Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Trp Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Ala Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Ser Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


<210>  45
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  45

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Trp Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Ser Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asn Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Ala Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


<210>  46
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  46

Met Ala Lys Leu Thr Ala Leu Thr Leu Ser Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Trp Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Ser Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Ile Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Ala Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


<210>  47
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  47

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Ser Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Ala Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Trp Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Ala Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Ser Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


<210>  48
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  48

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Ala Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Trp Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Ala Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Ser Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Val Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Phe Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


<210>  49
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  49

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Ala Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Trp Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Ala Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Ser Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


<210>  50
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  50

Met Ala Lys Leu Thr Ala Leu Thr Leu Ser Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Gly Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Trp Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn Lys Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Ser Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


<210>  51
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  51

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Trp Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


<210>  52
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  52

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Trp Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Ala Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


<210>  53
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  53

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Met Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Gly Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Thr Phe 
            100                 105                 110         


Asn Pro Trp Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn Arg Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Ser Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Ser Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


<210>  54
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  54

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Ala Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


<210>  55
<211>  1065
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  55
atggcgaaac tgaccgcgct gaccctgctg ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcctgaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgcatggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc atccggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gattttgcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcatgcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcaccgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgtgtt tcataaagcg ctgtattgcg aactg                     1065


<210>  56
<211>  1098
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  56
atggcgaaac tgaccgcgct gaccctgctg ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcggcaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgtggggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc gcccggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gatagcgcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcatgcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcagcgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgtgtt tcataaagcg ctgtattgcg aactggcggc ggcgctggaa     1080

catcatcatc atcatcat                                                   1098


<210>  57
<211>  1098
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  57
atggcgaaac tgaccgcgct gaccctgctg ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcgtgaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgctgggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc gcccggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gatagcgcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcatgcgc attctgtatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcagcgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgtgtt tcataaagcg ctgtattgcg aactggcggc ggcgctggaa     1080

catcatcatc atcatcat                                                   1098


<210>  58
<211>  1098
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  58
atggcgaaac tgaccgcgct gaccctgctg ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcggcaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggatattagc acctttaacc cgtggggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc gcccggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgccgctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gatagcgcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcatgcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcagcgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgtgtt tcataaagcg ctgtattgcg aactggcggc ggcgctggaa     1080

catcatcatc atcatcat                                                   1098


<210>  59
<211>  1098
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  59
atggcgaaac tgaccgcgct gaccctgctg ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcgtgaaa tttccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgctgggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc gcccggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaatttca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gatagcgcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcatgcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcagcgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgtgtt tcataaagcg ctgtattgcg aactggcggc ggcgctggaa     1080

catcatcatc atcatcat                                                   1098


<210>  60
<211>  1098
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  60
atggcgaaac tgaccgcgct gaccctgctg ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcgtgaaa tttccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgctgggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc gcccggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gatagcgcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcatgcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcagcgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgtgtt tcataaagcg ctgtattgcg aactggcggc ggcgctggaa     1080

catcatcatc atcatcat                                                   1098


<210>  61
<211>  1098
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  61
atggcgaaac tgaccgcgct gaccctgctg ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcgtgaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cggtgggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc gcccggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gatagcgcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcatgcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcagcgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgtgtt tcataaagcg ctgtattgcg aactggcggc ggcgctggaa     1080

catcatcatc atcatcat                                                   1098


<210>  62
<211>  1098
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  62
atggcgaaac tgaccgcgct gaccctgagc ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgagcccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcggcaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgtggggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc gcccggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gatagcgcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaacc gcaccctgac cccgatgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcatgcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcagcgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgtgtt tcataaagcg ctgtattgcg aactggcggc ggcgctggaa     1080

catcatcatc atcatcat                                                   1098


<210>  63
<211>  1098
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  63
atggcgaaac tgaccgcgct gaccctgctg ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcgtgaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgtggggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc gcccggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gatagcgcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcatgcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcagcgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgtgtt tcataaagcg ctgtattgcg aactggcggc ggcgctggaa     1080

catcatcatc atcatcat                                                   1098


<210>  64
<211>  1098
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  64
atggcgaaac tgaccgcgct gaccctgctg ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcgtgaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgctgggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaaca acccggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaactgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gatagcgcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcatgcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcagcgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgtgtt tcataaagcg ctgtattgcg aactggcggc ggcgctggaa     1080

catcatcatc atcatcat                                                   1098


<210>  65
<211>  1098
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  65
atggcgaaac tgaccgcgct gaccctgctg ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcctgaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgcatggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc atccggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gattttgcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcatgcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcaccgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgtgtt tcataaagcg ctgtattgcg aactggcggc ggcgctggaa     1080

catcatcatc atcatcat                                                   1098


<210>  66
<211>  1089
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  66
atggcgaaac tgaccgaact gaccctgctg ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcggcaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgtggggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc gcccggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gatagcgcga acggcattaa cattagcccg gatggcgaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcatgcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcagcgt gctgcagggc agcagcgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgtgtt tcataaagcg ctgtattgcg aactgcatca tcatcatcat     1080

catcatcat                                                             1089


<210>  67
<211>  1089
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  67
atggcgaaac tgaccgcgct gaccctgctg ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcggcaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgtggggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc gcccggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gattgcgcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcatgcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcaccgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgtgtt tcataaagcg ctgtattgcg aactgcatca tcatcatcat     1080

catcatcat                                                             1089


<210>  68
<211>  1089
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  68
atggcgaaac cgaccgcgct gaccctgctg ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcctgaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggc gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgtggggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc atgcggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaagtgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gatagcgcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcatgcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcaccgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgtgtt tcataaagcg ctgtattgcg aactgcatca tcatcatcat     1080

catcatcat                                                             1089


<210>  69
<211>  1089
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  69
atggcgaaac tgaccgcgct gaccctgctg ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcggcaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgtggggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaaca ccccggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gatctggcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcatgcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcaccgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgtgtt tcataaagcg ctgtattgcg aactgcatca tcatcatcat     1080

catcatcat                                                             1089


<210>  70
<211>  1089
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  70
atggcgaaac tgaccaccct gaccctgctg ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcctgaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggc gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgtggggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc atgcggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacaacgtgc gcgtggtggc ggaaggcttt      660

gatagcgcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcattcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcaccgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgtgtt tcataaagcg ctgtattgcg aactgcatca tcatcatcat     1080

catcatcat                                                             1089


<210>  71
<211>  1089
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  71
atggcgaaac tgaccgcgct gaccctgctg ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcctgaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgtggggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc atgcggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gattttgcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcatgcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcaccgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgcgtt tcataaagcg ctgtattgcg aactgcatca tcatcatcat     1080

catcatcat                                                             1089


<210>  72
<211>  1089
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  72
atggcgaaac tgaccgcgct gaccctgctg ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcctgaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgcatggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc atccggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gattttgcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaaagc      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggcgac cggcgatctg      840

tgggtgggct gccgcccgaa cggcatgcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcagcgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgtgtt tcataaagcg ctgtattgcg aactgcatca tcatcatcat     1080

catcatcat                                                             1089


<210>  73
<211>  1089
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  73
atggcgaaac tgaccgcgct gaccctgctg ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcctgaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggataccagc agctttaacc cgtggggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc atccggatag cagcccgacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gattttgcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcatgcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcaccgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgcgtt tcataaagcg ctgtattgcg aactgcatca tcatcatcat     1080

catcatcat                                                             1089


<210>  74
<211>  1089
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  74
atggcgaaac tgaccgcgct gaccctgctg ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcggcaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgtggggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc gcccggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gatagcgcga acggcattaa cattagcccg gatggcgaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcatgcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcaccgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgtgtt tcataaagcg ctgtattgcg aactgcatca tcatcatcat     1080

catcatcat                                                             1089


<210>  75
<211>  1089
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  75
atggcgaaac tgaccgcgct gaccctgctg ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcctgaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgcatggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc atccggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gattttgcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaaagc      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccgcccgaa cggcatgcgc atttttagct atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcaccgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgtgtt tcataaagcg ctgtattgcg aactgcatca tcatcatcat     1080

catcatcat                                                             1089


<210>  76
<211>  1089
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  76
atggcgaaac tgaccgcgct gaccctgctg ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

gattgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcctgaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgcatggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc atccggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gattttgcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaaagc      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccgcccgaa cggcatgcgc atttttagct atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcagcgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgtgtt tcataaagcg ctgtattgcg aactgcatca tcatcatcat     1080

catcatcat                                                             1089


<210>  77
<211>  1089
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  77
atggcgaaac tgaccgcgct gaccctgctg ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcctgaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgcatggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc atccggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg accgatgtgc gcgtggtggc ggaaggcttt      660

gattttgcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccgcccgaa cggcatgcgc atttttagct atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcagcgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgtgtt tcataaagcg ctgtattgcg aactgcatca tcatcatcat     1080

catcatcat                                                             1089


<210>  78
<211>  1089
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  78
atggcgaaac tgaccgcgct gaccctgagc ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcggcaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgtggggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc atgcggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gatagcgcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcatgcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcaccgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgtgtt tcataaagcg ctgtattgcg aactgcatca tcatcatcat     1080

catcatcat                                                             1089


<210>  79
<211>  1089
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  79
atggcgaaac tgaccgcgct gaccctgagc ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcgcgaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgtggggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc gcccggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gatagcgcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcatgcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcaccgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgtgtt tcataaagcg ctgtattgcg aactgcatca tcatcatcat     1080

catcatcat                                                             1089


<210>  80
<211>  1089
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  80
atggcgaaac tgaccgcgct gaccctgctg ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcctgaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggc gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgtggggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc atgcggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gatagcgcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcattcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcaccgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgtgtt tcataaagcg ctgtattgcg aactgcatca tcatcatcat     1080

catcatcat                                                             1089


<210>  81
<211>  1089
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  81
atggcgaaac tgaccgcgct gaccctgctg ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

gattgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcctgaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggatattccg agctttaacc cgcatggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc atccggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gattttgcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaaagc      720

ctggcgcgca aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatc tggataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcatgcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaag atggcaccgt gctgcagggc agcgcggtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgtgtt tcataaagcg ctgtattgcg aactgcatca tcatcatcat     1080

catcatcat                                                             1089


<210>  82
<211>  1089
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  82
atggcgaaac tgaccgcgct gaccctgctg ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcggcaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgtggggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc gcccggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaagtgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gatagcgcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcatgcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcagcgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgtgtt tcataaagcg ctgtattgcg aactgcatca tcatcatcat     1080

catcatcat                                                             1089


<210>  83
<211>  1089
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  83
atggcgaaac tgaccgcgct gaccctgctg ggcctgggcc tggcgctgag cgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcctgaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgtggggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc atccggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gattttgcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcatgcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcaccgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgcgtt tcataaagcg ctgtattgcg aactgcatca tcatcatcat     1080

catcatcat                                                             1089


<210>  84
<211>  1089
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  84
atggcgaaac tgaccgcgct gaccctgctg ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcggcaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgtggggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc atccggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gatctggcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcatgcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcaccgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgtgtt tcataaagcg ctgtattgcg aactgcatca tcatcatcat     1080

catcatcat                                                             1089


<210>  85
<211>  1089
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  85
atggcgaaac tgaccgcgct gaccctgctg ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcagcaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgtggggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc atgcggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gatagcgcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcatgcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcaccgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgtgtt tcataaagcg ctgtattgcg aactgcatca tcatcatcat     1080

catcatcat                                                             1089


<210>  86
<211>  1089
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  86
atggcgaaac tgaccgcgct gaccctgctg ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcctgaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgtggggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc atccggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gattttgcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcatgcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcaccgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgcgtt tcataaagcg ctgtattgcg aactgcatca tcatcatcat     1080

catcatcat                                                             1089


<210>  87
<211>  1089
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  87
atggcgaaac tgaccgcgct gaccctgctg ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcctgaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgtggggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc atccggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gattttgcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcatgcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcaccgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgtgat tcataaagcg ctgtattgcg aactgcatca tcatcatcat     1080

catcatcat                                                             1089


<210>  88
<211>  1089
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  88
atggcgaaac tgaccgcgct gaccctgctg ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcctgaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgtggggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc atccggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gatctggcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcatgcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcaccgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgcgtt tcataaagcg ctgtattgcg aactgcatca tcatcatcat     1080

catcatcat                                                             1089


<210>  89
<211>  1089
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  89
atggcgaaac tgaccgcgct gaccctgctg ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcctgaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgtggggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc atccggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gattttgcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcattcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcaccgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgcgtt tcataaagcg ctgtattgcg aactgcatca tcatcatcat     1080

catcatcat                                                             1089


<210>  90
<211>  1089
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  90
atggcgaaac tgaccgcgct gaccctgctg ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcctgaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgtggggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc atccggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gatctggcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcatgcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcaccgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgcgtt tcataaagcg ctgtattgcg aactgcatca tcatcatcat     1080

catcatcat                                                             1089


<210>  91
<211>  1089
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  91
atggcgaaac tgaccgcgct gaccctgctg ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcctgaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgtggggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc atccggatag cagcccgacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcat gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gattttgcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcatgcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcaccgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgcgtt tcataaagcg ctgtattgcg aactgcatca tcatcatcat     1080

catcatcat                                                             1089


<210>  92
<211>  1089
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  92
atggcgaaac tgaccgcgct gaccctgctg ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcctgaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgtggggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc atccggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gattttgcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcatgcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcaccgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgcgtt tcataaagcg ctgtattgcg aactgcatca tcatcatcat     1080

catcatcat                                                             1089


<210>  93
<211>  1089
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  93
atggcgaaac tgaccgcgct gaccctgctg ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcggcaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgtggggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc atccggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gatagcgcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcatgcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcaccgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgtgtt tcataaagcg ctgtattgcg aactgcatca tcatcatcat     1080

catcatcat                                                             1089


<210>  94
<211>  1089
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  94
atggcgaaac tgaccgcgct gaccctgagc ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctataacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcggcaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgtggggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc gcccggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gatagcgcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcatgcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcagcgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgtgtt tcataaagcg ctgtattgcg aactgcatca tcatcatcat     1080

catcatcat                                                             1089


<210>  95
<211>  1089
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  95
atggcgaaac tgaccgcgct gaccctgctg ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcctgaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgtggggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc atccggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gatgtggcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcatgcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcaccgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgtgtt tcataaagcg ctgtattgcg aactgcatca tcatcatcat     1080

catcatcat                                                             1089


<210>  96
<211>  1089
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  96
atggcgaaac tgaccgcgct gaccctgctg ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcctgaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggc gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgtggggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc atgcggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaagtgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gatagcgcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcattcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcaccgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgtgtt tcataaagcg ctgtattgcg aactgcatca tcatcatcat     1080

catcatcat                                                             1089


<210>  97
<211>  1089
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  97
atggcgaaac tgaccgcgct gaccctgagc ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcagcaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgtggggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc atgcggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gatagcgcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcatgcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcaccgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgtgtt tcataaagcg ctgtattgcg aactgcatca tcatcatcat     1080

catcatcat                                                             1089


<210>  98
<211>  1089
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  98
atggcgaaac tgaccgcgct gaccctgagc ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcctgaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgtggggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc atgcggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gatagcgcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcatgcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcaccgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgtgtt tcataaagcg ctgtattgcg aactgcatca tcatcatcat     1080

catcatcat                                                             1089


<210>  99
<211>  1089
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  99
atggcgaaac tgaccgcgct gaccctgctg ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcctgaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgtggggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc atccggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gatagcgcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcatgcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcagaacatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcaccgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgcgtt tcataaagcg ctgtattgcg aactgcatca tcatcatcat     1080

catcatcat                                                             1089


<210>  100
<211>  1089
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  100
atggcgaaac tgaccgcgct gaccctgagc ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcctgaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgtggggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc atccggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gatagcgcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcattcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcaccgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgcgtt tcataaagcg ctgtattgcg aactgcatca tcatcatcat     1080

catcatcat                                                             1089


<210>  101
<211>  1089
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  101
atggcgaaac tgaccgcgct gaccctgctg ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcagcaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggc gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgtggggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc atgcggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gatagcgcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcatgcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcaccgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgtgtt tcataaagcg ctgtattgcg aactgcatca tcatcatcat     1080

catcatcat                                                             1089


<210>  102
<211>  1089
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  102
atggcgaaac tgaccgcgct gaccctgctg ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcctgaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggc gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgtggggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc atgcggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gatagcgcga acggcattaa cattagcccg gatggcaaat atgtgtatgt ggcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agctttgatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcatgcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcaccgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgtgtt tcataaagcg ctgtattgcg aactgcatca tcatcatcat     1080

catcatcat                                                             1089


<210>  103
<211>  1089
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  103
atggcgaaac tgaccgcgct gaccctgctg ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcctgaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggc gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgtggggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc atgcggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gatagcgcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcatgcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcaccgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgtgtt tcataaagcg ctgtattgcg aactgcatca tcatcatcat     1080

catcatcat                                                             1089


<210>  104
<211>  1089
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  104
atggcgaaac tgaccgcgct gaccctgagc ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcggcaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgtggggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaaca aaccggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gatagcgcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcatgcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcaccgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgtgtt tcataaagcg ctgtattgcg aactgcatca tcatcatcat     1080

catcatcat                                                             1089


<210>  105
<211>  1089
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  105
atggcgaaac tgaccgcgct gaccctgctg ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcctgaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgtggggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc atccggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gattttgcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcatgcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcaccgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgtgtt tcataaagcg ctgtattgcg aactgcatca tcatcatcat     1080

catcatcat                                                             1089


<210>  106
<211>  1089
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  106
atggcgaaac tgaccgcgct gaccctgctg ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcctgaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgtggggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc atccggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gattttgcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcatgcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcaccgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgcgtt tcataaagcg ctgtattgcg aactgcatca tcatcatcat     1080

catcatcat                                                             1089


<210>  107
<211>  1089
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  107
atggcgaaac tgaccgcgct gaccctgctg ggcctgggca tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcggcaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggatattagc acctttaacc cgtggggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc gcccggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gatagcgcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcatgcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcagcgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgtgtt tcataaagcg ctgtattgcg aactgcatca tcatcatcat     1080

catcatcat                                                             1089


<210>  108
<211>  1089
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  108
atggcgaaac tgaccgcgct gaccctgctg ggcctgggcc tggcgctgtt tgatggccag       60

aaaagcagct ttcagacccg ctttaacgtg catcgcgaag tgaccccggt ggaactgccg      120

aactgcaacc tggtgaaagg cgtggataac ggcagcgaag atctggaaat tctgccgaac      180

ggcctggcgt ttattagcag cggcctgaaa tatccgggca ttatgagctt tgatccggat      240

aaaagcggca aaattctgct gatggatctg aacgaagaag atccggtggt gctggaactg      300

ggcattaccg gcaacaccct ggatattagc agctttaacc cgcatggcat tagcaccttt      360

accgatgaag ataacaccgt gtatctgctg gtggtgaacc atccggatag cagcagcacc      420

gtggaagtgt ttaaatttca ggaagaagaa aaaagcctgc tgcatctgaa aaccattcgc      480

cataaactgc tgccgagcgt gaacgatatt gtggcggtgg gcccggaaca tttttatgcg      540

accaacgatc attattttgc ggatccgtat ctgaaaagct gggaaatgca tctgggcctg      600

gcgtggagct ttgtgaccta ttatagcccg aacgatgtgc gcgtggtggc ggaaggcttt      660

gattttgcga acggcattaa cattagcccg gatggcaaat atgtgtatat tgcggaactg      720

ctggcgcata aaattcatgt gtatgaaaaa catgcgaact ggaccctgac cccgctgaaa      780

agcctggatt ttgataccct ggtggataac attagcgtgg atccggtgac cggcgatctg      840

tgggtgggct gccatccgaa cggcatgcgc attttttatt atgatccgaa aaacccgccg      900

ggcagcgaag tgctgcgcat tcaggatatt ctgagcgaag aaccgaaagt gaccgtggtg      960

tatgcggaaa acggcaccgt gctgcagggc agcaccgtgg cggcggtgta taaaggcaaa     1020

ctgctgattg gcaccgcgtt tcataaagcg ctgtattgcg aactgcatca tcatcatcat     1080

catcatcat                                                             1089


<210>  109
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  109
gatggcgccc aacagtcc                                                     18


<210>  110
<211>  15
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  110
gcgcgtccca ttcgc                                                        15


<210>  111
<211>  47
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  111
tgatctagtg cggccgccag ctcacagtaa agagctttgt gaaacac                     47


<210>  112
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  112
gtccggcgta gaggatcg                                                     18


<210>  113
<211>  43
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n is a, c, g, or t

<400>  113
ggctttcatc agctccggan nsaagtatcc tggaataatg agc                         43


<210>  114
<211>  32
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide


<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  n is a, c, g, or t

<400>  114
cttcatttaa ccctnnsggg attagcacat tc                                     32


<210>  115
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  n is a, c, g, or t

<400>  115
ctactggtgg taaacnnscc agactcctcg tcc                                    33


<210>  116
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide


<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  n is a, c, g, or t

<400>  116
gttgattccg ttagcsnnat caaatccttc tgc                                    33


<210>  117
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide


<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  n is a, c, g, or t

<400>  117
gagctttgtg aaasnntgtg ccaatcagca g                                      31


<210>  118
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide


<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  n is a, c, g, or t

<400>  118
gtaaagagct ttgtgsnnca ctgtgccaat cag                                    33


<210>  119
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  n is a, c, g, or t

<400>  119
cagtaaagag ctttsnnaaa cactgtgcca atc                                    33


<210>  120
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  120

Met Ala Lys Leu Thr Glu Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Gly Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Trp Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn Arg Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Ser Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Glu Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Ser Val Leu Gln Gly Ser Ser Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


<210>  121
<211>  366
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  121

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Val Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Leu Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn Arg Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Met Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Ser Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu Ala Ala Ala Leu Glu His His His His His His 
        355                 360                 365     


<210>  122
<211>  366
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  122

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Val Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Ala Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn Arg Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Met Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Gly Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Ser Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu Ala Ala Ala Leu Glu His His His His His His 
        355                 360                 365     


<210>  123
<211>  366
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  123

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Leu 
    50                  55                  60                  


Ile Ser Ser Gly Val Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Val Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn Arg Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Met Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Ser Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu Ala Ala Ala Leu Glu His His His His His His 
        355                 360                 365     


<210>  124
<211>  366
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  124

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Val Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Val Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn Arg Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Val Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Ser Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu Ala Ala Ala Leu Glu His His His His His His 
        355                 360                 365     


<210>  125
<211>  366
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  125

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Val Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Ala Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn Arg Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Met Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Gly Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Ser Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu Ala Ala Ala Leu Glu His His His His His His 
        355                 360                 365     


<210>  126
<211>  366
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  126

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Asn Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Leu Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn Arg Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Met Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Ile Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Ser Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu Ala Ala Ala Leu Glu His His His His His His 
        355                 360                 365     


<210>  127
<211>  366
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  127

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Ile Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Val Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Ala Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn Arg Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Met Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Phe Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Ser Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu Ala Ala Ala Leu Glu His His His His His His 
        355                 360                 365     


<210>  128
<211>  366
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  128

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Ile Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Val Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Leu Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn Arg Pro His Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Met Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Leu Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Ser Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu Ala Ala Ala Leu Glu His His His His His His 
        355                 360                 365     


<210>  129
<211>  366
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  129

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Met Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Val Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Ala Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn Arg Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Met Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Leu Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Ser Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu Ala Ala Ala Leu Glu His His His His His His 
        355                 360                 365     


<210>  130
<211>  1101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  130
atggctaaac tgacagcgct cacactcttg gggctgggat tggcactctt cgatggacag       60

aagtcttctt tccaaacacg atttaatgtt caccgtgaag taactccagt ggaacttcct      120

aactgtaatt tagttaaagg ggttgacaat ggttctgaag acttggaaat actgcccaat      180

ggactggctt tcatcagctc cggagtgaag tatcctggaa taatgagctt tgaccctgat      240

aagtctggaa agatacttct aatggacctg aatgaggaag acccagtagt gttggaactg      300

ggcattactg gaaatacatt ggatatatct tcatttaacc ctgcggggat tagcacattc      360

acagatgaag ataacactgt gtacctactg gtggtaaaca ggccagactc ctcgtccacc      420

gtggaggtgt ttaaatttca agaagaagaa aaatcacttt tgcatctgaa aaccatcaga      480

cacaagcttc tgcctagtgt gaatgacatt gtcgctgtgg gacctgaaca cttttatgcc      540

acaaatgatc actattttgc tgacccttac ttaaaatcat gggaaatgca tttgggatta      600

gcgtggtcat ttgttactta ttatagtccc aatgatgttc gagtagtggc agaaggattt      660

gatatggcta acggaatcaa catctcacca gacggcaagt atgtctatat agctgagttg      720

ctggctcata agatccatgt gtatgaaaag cacgctaatt ggactttaac tccattgaag      780

tccctcgact ttgacaccct tgtggataac atctctgtgg atcctgtgac aggggacctc      840

tgggtgggat gccatcccaa cggaatgcga atcttctact atgacccaaa gaatcctccc      900

ggctcagagg tgcttcgaat ccaggacatt ttatccgaag agcccaaagt gacagtggtt      960

tatgcagaaa atggcactgt attacagggc agctcggtgg ccgctgtgta caaagggaaa     1020

ctgctgattg gcacagtgtt tcacaaagct ctttactgtg agctggcggc cgcactcgag     1080

caccaccacc accaccactg a                                               1101


<210>  131
<211>  1101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  131
atggctaaac tgacagcgct cacactcttg gggctgggat tggcactctt cgatggacag       60

aagtcttctt tccaaacacg atttaatgtt caccgtgaag taactccagt ggaacttcct      120

aactgtaatt tagttaaagg ggttgacaat ggttctgaag acttggaaat actgcccaat      180

ggactggctt tcatcagctc cggagtgaag tatcctggaa taatgagctt tgaccctgat      240

aagtctggaa agatacttct aatggacctg aatgaggaag acccagtagt gttggaactg      300

ggcattactg gaaatacatt ggatatatct tcatttaacc ctctggggat tagcacattc      360

acagatgaag ataacactgt gtacctactg gtggtaaaca ggccagactc ctcgtccacc      420

gtggaggtgt ttaaatttca agaagaagaa aaatcacttt tgcatctgaa aaccatcaga      480

cacaagcttc tgcctagtgt gaatgacatt gtcgctgtgg gacctgaaca cttttatgcc      540

acaaatgatc actattttgc tgacccttac ttaaaatcat gggaaatgca tttgggatta      600

gcgtggtcat ttgttactta ttatagtccc aatgatgttc gagtagtggc agaaggattt      660

gatatggcta acggaatcaa catctcacca gacggcaagt atgtctatat agctgagttg      720

ctggctcata agatccatgt gtatgaaaag cacgctaatt ggactttaac tccattgaag      780

tccctcgact ttgacaccct tgtggataac atctctgtgg atcctgtgac aggggacctc      840

tgggtgggat gccatcccaa cggaatgcga atcttctact atgacccaaa gaatcctccc      900

ggctcagagg tgcttcgaat ccaggacatt ttatccgaag agcccaaagt gacagtggtt      960

tatgcagaaa atggcactgt attacagggc agctcggtgg ccgctgtgta caaagggaaa     1020

ctgctgattg gcacagtgtt tcacaaagct ctttactgtg agctggcggc cgcactcgag     1080

caccaccacc accaccactg a                                               1101


<210>  132
<211>  1101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  132
atggctaaac tgacagcgct cacactcttg gggctgggat tggcactctt cgatggacag       60

aagtcttctt tccaaacacg atttaatgtt caccgtgaag taactccagt ggaacttcct      120

aactgtaatt tagttaaagg ggttgacaat ggttctgaag acttggaaat actgcccaat      180

ggactggctt tcatcagctc cggagtgaag tatcctggaa taatgagctt tgaccctgat      240

aagtctggaa agatacttct aatggacctg aatgaggaag acccagtagt gttggaactg      300

ggcattactg gaaatacatt ggatatatct tcatttaacc ctgcggggat tagcacattc      360

acagatgaag ataacactgt gtacctactg gtggtaaaca ggccagactc ctcgtccacc      420

gtggaggtgt ttaaatttca agaagaagaa aaatcacttt tgcatctgaa aaccatcaga      480

cacaagcttc tgcctagtgt gaatgacatt gtcgctgtgg gacctgaaca cttttatgcc      540

acaaatgatc actattttgc tgacccttac ttaaaatcat gggaactgca tttgggatta      600

gcgtggtcat ttgttactta ttatagtccc aatgatgttc gagtagtggc agaaggattt      660

gatatggcta acggaatcaa catctcacca gacggcaagt atgtctatat agctgagttg      720

ctggctcata agatccatgt gtatgaaaag cacgctaatt ggactttaac tccattgaag      780

tccctcgact ttgacaccct tgtggataac atctctgtgg atcctgtgac aggggacctc      840

tgggtgggat gccatcccaa cggaatgcga atcttctact atgacccaaa gaatcctccc      900

ggctcagagg tgcttcgaat ccaggacatt ttatccgaag agcccaaagt gacagtggtt      960

tatgcagaaa atggcactgt attacagggc agctcggtgg ccgctgtgta caaagggaaa     1020

ctgctgattg gcacagtgtt tcacaaagct ctttactgtg agctggcggc cgcactcgag     1080

caccaccacc accaccactg a                                               1101


<210>  133
<211>  1101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  133
atggctaaac tgacagcgct cacactcttg gggctgggat tggcactctt cgatggacag       60

aagtcttctt tccaaacacg atttaatgtt caccgtgaag taactccagt ggaacttcct      120

aactgtaatt tagttaaagg ggttgacaat ggttctgaag acttggaaat actgcccaat      180

ggactggctc tcatcagctc cggagtgaag tatcctggaa taatgagctt tgaccctgat      240

aagtctggaa agatacttct aatggacctg aatgaggaag acccagtagt gttggaactg      300

ggcattactg gaaatacatt ggatatatct tcatttaacc ctgtggggat tagcacattc      360

acagatgaag ataacactgt gtacctactg gtggtaaaca ggccagactc ctcgtccacc      420

gtggaggtgt ttaaatttca agaagaagaa aaatcacttt tgcatctgaa aaccatcaga      480

cacaagcttc tgcctagtgt gaatgacatt gtcgctgtgg gacctgaaca cttttatgcc      540

acaaatgatc actattttgc tgacccttac ttaaaatcat gggaaatgca tttgggatta      600

gcgtggtcat ttgttactta ttatagtccc aatgatgttc gagtagtggc agaaggattt      660

gatatggcta acggaatcaa catctcacca gacggcaagt atgtctatat agctgagttg      720

ctggctcata agatccatgt gtatgaaaag cacgctaatt ggactttaac tccattgaag      780

tccctcgact ttgacaccct tgtggataac atctctgtgg atcctgtgac aggggacctc      840

tgggtgggat gccatcccaa cggaatgcga atcttctact atgacccaaa gaatcctccc      900

ggctcagagg tgcttcgaat ccaggacatt ttatccgaag agcccaaagt gacagtggtt      960

tatgcagaaa atggcactgt attacagggc agctcggtgg ccgctgtgta caaagggaaa     1020

ctgctgattg gcacagtgtt tcacaaagct ctttactgtg agctggcggc cgcactcgag     1080

caccaccacc accaccactg a                                               1101


<210>  134
<211>  1101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  134
atggctaaac tgacagcgct cacactcttg gggctgggat tggcactctt cgatggacag       60

aagtcttctt tccaaacacg atttaatgtt caccgtgaag taactccagt ggaacttcct      120

aactgtaatt tagttaaagg ggttgacaat ggttctgaag acttggaaat actgcccaat      180

ggactggctt tcatcagctc cggagtgaag tatcctggaa taatgagctt tgaccctgat      240

aagtctggaa agatacttct aatggacctg aatgaggaag acccagtagt gttggaactg      300

ggcattactg gaaatacatt ggatatatct tcatttaacc ctgtggggat tagcacattc      360

acagatgaag ataacactgt gtacctactg gtggtaaaca ggccagactc ctcgtccacc      420

gtggaggtgt ttaaatttca agaagaagaa aaatcacttt tgcatctgaa aaccatcaga      480

cacaagcttc tgcctagtgt gaatgacatt gtcgctgtgg gacctgaaca cttttatgcc      540

acaaatgatc actattttgc tgacccttac ttaaaatcat gggaaatgca tttgggatta      600

gcgtggtcat ttgttactta ttatagtccc aatgatgttc gagtagtggc agaaggattt      660

gatgtggcta acggaatcaa catctcacca gacggcaagt atgtctatat agctgagttg      720

ctggctcata agatccatgt gtatgaaaag cacgctaatt ggactttaac tccattgaag      780

tccctcgact ttgacaccct tgtggataac atctctgtgg atcctgtgac aggggacctc      840

tgggtgggat gccatcccaa cggaatgcga atcttctact atgacccaaa gaatcctccc      900

ggctcagagg tgcttcgaat ccaggacatt ttatccgaag agcccaaagt gacagtggtt      960

tatgcagaaa atggcactgt attacagggc agctcggtgg ccgctgtgta caaagggaaa     1020

ctgctgattg gcacagtgtt tcacaaagct ctttactgtg agctggcggc cgcactcgag     1080

caccaccacc accaccactg a                                               1101


<210>  135
<211>  1101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  135
atggctaaac tgacagcgct cacactcttg gggctgggat tggcactctt cgatggacag       60

aagtcttctt tccaaacacg atttaatgtt caccgtgaag taactccagt ggaacttcct      120

aactgtaatt tagttaaagg ggttgacaat ggttctgaag acttggaaat actgcccaat      180

ggactggctt tcatcagctc cggagtgaag tatcctggaa taatgagctt tgaccctgat      240

aagtctggaa agatacttct aatggacctg aatgaggaag acccagtagt gttggaactg      300

ggcattactg gaaatacatt ggatatatct tcatttaacc ctgcggggat tagcacattc      360

acagatgaag ataacactgt gtacctactg gtggtaaaca ggccagactc ctcgtccacc      420

gtggaggtgt ttaaatttca agaagaagaa aaatcacttt tgcatctgaa aaccatcaga      480

cacaagcttc tgcctagtgt gaatgacatt gtcgctgtgg gacctgaaca cttttatgcc      540

acaaatgatc actattttgc tgacccttac ttaaaatcat gggaaatgca tttgggatta      600

gcgtggtcat ttgttactta ttatagtccc aatgatgttc gagtagtggc agaaggattt      660

gatatggcta acggaatcaa catctcacca gacggcaagt atgtctatat agctgagttg      720

ctggctcata agatccatgt gtatgaaaag cacgctaatt ggactttaac tccattgaag      780

tccctcgact ttgacaccct tgtggataac atctctgtgg atcctgtgac aggggacctc      840

tgggtgggat gccatcccaa cggaatgcga atcttctact atgacccaaa gaatcctccc      900

ggctcagagg tgcttcgaat ccagggcatt ttatccgaag agcccaaagt gacagtggtt      960

tatgcagaaa atggcactgt attacagggc agctcggtgg ccgctgtgta caaagggaaa     1020

ctgctgattg gcacagtgtt tcacaaagct ctttactgtg agctggcggc cgcactcgag     1080

caccaccacc accaccactg a                                               1101


<210>  136
<211>  1101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  136
atggctaaac tgacagcgct cacactcttg gggctgggat tggcactctt cgatggacag       60

aagtcttctt tccaaacacg atttaatgtt caccgtgaag taactccagt ggaacttcct      120

aactgtaatt tagttaaagg ggttgacaat ggttctgaag acttggaaat actgcccaat      180

ggactggctt tcatcagctc cggactgaac tatcctggaa taatgagctt tgaccctgat      240

aagtctggaa agatacttct aatggacctg aatgaggaag acccagtagt gttggaactg      300

ggcattactg gaaatacatt ggatatatct tcatttaacc ctctggggat tagcacattc      360

acagatgaag ataacactgt gtacctactg gtggtaaaca ggccagactc ctcgtccacc      420

gtggaggtgt ttaaatttca agaagaagaa aaatcacttt tgcatctgaa aaccatcaga      480

cacaagcttc tgcctagtgt gaatgacatt gtcgctgtgg gacctgaaca cttttatgcc      540

acaaatgatc actattttgc tgacccttac ttaaaatcat gggaaatgca tttgggatta      600

gcgtggtcat ttgttactta ttatagtccc aatgatgttc gagtagtggc agaaggattt      660

gatatggcta acggaatcaa catctcacca gacggcaagt atgtctatat agctgagttg      720

ctggctcata agatccatgt gtatgaaaag cacgctaatt ggactttaac tccattgaag      780

tccctcgact ttgacaccct tgtggataac atctctgtgg atcctgtgac aggggacctc      840

tgggtgggat gccatcccaa cggaatgcga atcttctact atgacccaaa gaatcctccc      900

ggctcagagg tgcttcgaat ccaggacatt ttatccgaag agcccaaagt gacagtggtt      960

tatgcagaaa atggcactgt attacagggc agctcggtgg ccgctgtgta caaagggaaa     1020

ctgctgattg gcacagtgtt tcacaaagct ctttactgtg agctggcggc cgcactcgag     1080

caccaccacc accaccactg a                                               1101


<210>  137
<211>  1101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  137
atggctaaac tgacagcgct cacactcttg gggctgggat tggcactctt cgatggacag       60

aagtcttctt tccaaacacg atttaatgtt caccgtgaag taactccagt ggaacttcct      120

aactgtaatt tagttaaagg ggttgacaat ggttctgaag acattgaaat actgcccaat      180

ggactggctt tcatcagctc cggagtgaag tatcctggaa taatgagctt tgaccctgat      240

aagtctggaa agatacttct aatggacctg aatgaggaag acccagtagt gttggaactt      300

ggcattactg gaaatacatt ggatatatct tcatttaacc ctgcggggat tagcacattc      360

acagatgaag ataacactgt gtacctactg gtggtaaaca ggccagactc ctcgtccacc      420

gtggaggtgt ttaaatttca agaagaagaa aaatcacttt tgcatctgaa aaccatcaga      480

cacaagcttc tgcctagtgt gaatgacatt gtcgctgtgg gacctgaaca cttttatgcc      540

acaaatgatc actattttgc tgacccttac ttaaaatcat gggaaatgca tttgggatta      600

gcgtggtcat ttgttactta ttatagtccc aatgatgttc gagtagtggc agaaggattt      660

gatatggcta acggaatcaa catctcacca gacggcaagt atgtctatat agctgagttg      720

ctggctcata agatccatgt gtatgaaaag cacgctaatt ggactttaac tccattgaag      780

tccctcgact ttgacaccct tgtggataac atctctgtgg atcctgtgac aggggacctc      840

tgggtgggat gccatcccaa cggaatgcga tttttctact atgacccaaa gaatcctccc      900

ggctcagagg tgcttcgaat ccaggacatt ttatccgaag agcccaaagt gacagtggtt      960

tatgcagaaa atggcactgt attacagggc agctcggtgg ccgctgtgta caaagggaaa     1020

ctgctgattg gcacagtgtt tcacaaagct ctttactgtg agctggcggc cgcactcgag     1080

caccaccacc accaccactg a                                               1101


<210>  138
<211>  1101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  138
atggctaaac tgacagcgct cacactcttg gggctgggat tggcactctt cgatggacag       60

aagtcttctt tccaaacacg atttaatgtt caccgtgaag taactccagt ggaacttcct      120

aactgtaatt tagttaaagg ggttgacaat ggttctgaag acattgaaat actgcccaat      180

ggactggctt tcatcagctc cggagtgaag tatcctggaa taatgagctt tgaccctgat      240

aagtctggaa agatacttct aatggacctg aatgaggaag acccagtagt gttggaactg      300

ggcattactg gaaatacatt ggatatatct tcatttaacc ctctggggat tagcacattc      360

acagatgaag ataacactgt gtacctactg gtggtaaaca ggccacattc ctcgtccacc      420

gtggaggtgt ttaaatttca agaagaagaa aaatcacttt tgcatctgaa aaccatcaga      480

cacaagcttc tgcctagtgt gaatgacatt gtcgctgtgg gacctgaaca cttttatgcc      540

acaaatgatc actattttgc tgacccttac ttaaaatcat gggaaatgca tttgggatta      600

gcgtggtcat ttgttactta ttatagtccc aatgatgttc gagtagtggc agaaggattt      660

gatatggcta acggaatcaa catctcacca gacggcaagt atgtctatat agctgagttg      720

ctggctcata agatccatgt gtatgaaaag cacgctaatt ggactttaac tccattgaag      780

tccctcgact ttgacaccct tgtggataac atctctgtgg atcctgtgac aggggacctc      840

tgggtgggat gccatcccaa cggaatgcga ctgttctact atgacccaaa gaatcctccc      900

ggctcagagg tgcttcgaat ccaggacatt ttatccgaag agcccaaagt gacagtggtt      960

tatgcagaaa atggcactgt attacagggc agctcggtgg ccgctgtgta caaagggaaa     1020

ctgctgattg gcacagtgtt tcacaaagct ctttactgtg agctggcggc cgcactcgag     1080

caccaccacc accaccactg a                                               1101


<210>  139
<211>  1101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant coding sequence

<400>  139
atggctaaac tgacagcgct cacactcttg gggctgggat tggcactctt cgatggacag       60

aagtcttctt tccaaacacg atttaatgtt caccgtgaag taactccagt ggaacttcct      120

aactgtaatt tagttaaagg ggttgacaat ggttctgaag acatggaaat actgcccaat      180

ggactggctt tcatcagctc cggagtgaag tatcctggaa taatgagctt tgaccctgat      240

aagtctggaa agatacttct aatggacctg aatgaggaag acccagtagt gttggaactg      300

ggcattactg gaaatacatt ggatatatct tcatttaacc ctgcggggat tagcacattc      360

acagatgaag ataacactgt gtacctactg gtggtaaaca ggccagactc ctcgtccacc      420

gtggaggtgt ttaaatttca agaagaagaa aaatcacttt tgcatctgaa aaccatcaga      480

cacaagcttc tgcctagtgt gaatgacatt gtcgctgtgg gacctgaaca cttttatgcc      540

acaaatgatc actattttgc tgacccttac ttaaaatcat gggaaatgca tttgggatta      600

gcgtggtcat ttgttactta ttatagtccc aatgatgttc gagtagtggc agaaggattt      660

gatatggcta acggaatcaa catctcacca gacggcaagt atgtctatat agctgagttg      720

ctggctcata agatccatgt gtatgaaaag cacgctaatt ggactttaac tccattgaag      780

tccctcgact ttgacaccct tgtggataac atctctgtgg atcctgtgac aggggacctc      840

tgggtgggat gccatcccaa cggaatgcga ctgttctact atgacccaaa gaatcctccc      900

ggctcagagg tgcttcgaat ccaggacatt ttatccgaag agcccaaagt gacagtggtt      960

tatgcagaaa atggcactgt attacagggc agctcggtgg ccgctgtgta caaagggaaa     1020

ctgctgattg gcacagtgtt tcacaaagct ctttactgtg agctggcggc cgcactcgag     1080

caccaccacc accaccactg a                                               1101


<210>  140
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  140

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Val Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Ala Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn Arg Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Met Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Leu Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Ser Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


<210>  141
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  141

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Ile Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Val Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Ala Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn Arg Pro Asp Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met Arg Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Met Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Leu Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Ser Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


<210>  142
<211>  363
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Serum paraoxonase (PON1) Variant amino acid sequence

<400>  142

Met Ala Lys Leu Thr Ala Leu Thr Leu Leu Gly Leu Gly Leu Ala Leu 
1               5                   10                  15      


Phe Asp Gly Gln Lys Ser Ser Phe Gln Thr Arg Phe Asn Val His Arg 
            20                  25                  30          


Glu Val Thr Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Val 
        35                  40                  45              


Asp Asn Gly Ser Glu Asp Ile Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Val Lys Tyr Pro Gly Ile Met Ser Phe Asp Pro Asp 
65                  70                  75                  80  


Lys Ser Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Val 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Asn Thr Leu Asp Ile Ser Ser Phe 
            100                 105                 110         


Asn Pro Ala Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Thr Val Tyr 
        115                 120                 125             


Leu Leu Val Val Asn Arg Pro Gln Ser Ser Ser Thr Val Glu Val Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Ser Val Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Ala Thr Asn Asp His Tyr Phe Ala Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met His Leu Gly Leu Ala Trp Ser Phe Val Thr Tyr Tyr 
        195                 200                 205             


Ser Pro Asn Asp Val Arg Val Val Ala Glu Gly Phe Asp Met Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asp Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Val Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Arg Leu Phe Tyr Tyr Asp Pro Lys Asn Pro Pro Gly Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asp Ile Leu Ser Glu Glu Pro Lys Val Thr Val Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Ser Val Ala Ala Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu His His His His His His His His 
        355                 360             


