                         SEQUENCE LISTING

<110>  ScaraTech Medical AB
       Tryggvason, Karl
       Pikkarainen, Timo
       Ojala, Juha
       Axelsson, Jonas
 
<120>  CHIMERIC PROTEINS FOR TREATMENT OF DISEASES

<130>  SCAR 200003US01

<150>  61/609523
<151>  2012-03-12

<160>  51    

<170>  PatentIn version 3.5

<210>  1
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker or affinity tag

<400>  1

Ser Val Glu Ala 
1               


<210>  2
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker or affinity tag

<400>  2

Asp Met Asp Phe 
1               


<210>  3
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant protein

<400>  3

Met Gly Ala Ala Ala Arg Thr Leu Arg Leu Ala Leu Gly Leu Leu Leu 
1               5                   10                  15      


Leu Ala Thr Leu Leu Arg Pro Ala Asp Ala Ser Ser Ala Pro His His 
            20                  25                  30          


His His His His Asp Ala Gly Gly Arg Pro Arg Ser Ser Pro Asp Asp 
        35                  40                  45              


Leu Lys Ala Leu Thr Arg Asn Val Asn Arg Leu Asn Glu Ser Phe Arg 
    50                  55                  60                  


Asp Leu Gln Leu Arg Leu Leu Gln Ala Pro Leu Gln Ala Asp Leu Thr 
65                  70                  75                  80  


Glu Gln Val Trp Lys Val Gln Asp Ala Leu Gln Asn Gln Ser Asp Ser 
                85                  90                  95      


Leu Leu Ala Leu Ala Gly Ala Val Gln Arg Leu Glu Gly Ala Leu Trp 
            100                 105                 110         


Gly Leu Gln Ala Gln Ala Val Gln Thr Glu Gln Ala Val Ala Leu Leu 
        115                 120                 125             


Arg Asp Arg Thr Gly Gln Gln Ser Asp Thr Ala Gln Leu Glu Leu Tyr 
    130                 135                 140                 


Gln Leu Gln Val Glu Ser Asn Ser Ser Gln Leu Leu Leu Arg Arg His 
145                 150                 155                 160 


Ala Gly Leu Leu Asp Gly Leu Ala Arg Arg Val Gly Ile Leu Gly Glu 
                165                 170                 175     


Glu Leu Ala Asp Val Gly Gly Val Leu Arg Gly Leu Asn His Ser Leu 
            180                 185                 190         


Ser Tyr Asp Val Ala Leu His Arg Thr Arg Leu Gln Asp Leu Arg Val 
        195                 200                 205             


Leu Val Ser Asn Ala Ser Glu Asp Thr Arg Arg Leu Arg Leu Ala His 
    210                 215                 220                 


Val Gly Met Glu Leu Gln Leu Lys Gln Glu Leu Ala Met Leu Asn Ala 
225                 230                 235                 240 


Val Thr Glu Asp Leu Arg Leu Lys Asp Trp Glu His Ser Ile Ala Leu 
                245                 250                 255     


Arg Asn Ile Ser Leu Ala Lys Gly Pro Pro Gly Pro Lys Gly Asp Gln 
            260                 265                 270         


Gly Asp Glu Gly Lys Glu Gly Arg Pro Gly Ile Pro Gly Leu Pro Gly 
        275                 280                 285             


Leu Arg Gly Leu Pro Gly Glu Arg Gly Thr Pro Gly Leu Pro Gly Pro 
    290                 295                 300                 


Lys Gly Asp Asp Gly Lys Leu Gly Ala Thr Gly Pro Met Gly Met Arg 
305                 310                 315                 320 


Gly Phe Lys Gly Asp Arg Gly Pro Lys Gly Glu Lys Gly Glu Lys Gly 
                325                 330                 335     


Asp Arg Ala Gly Asp Ala Ser Gly Val Glu Ala Pro Met Met Ile Arg 
            340                 345                 350         


Leu Val Asn Gly Ser Gly Pro His Glu Gly Arg Val Glu Val Tyr His 
        355                 360                 365             


Asp Arg Arg Trp Gly Thr Val Cys Asp Asp Gly Trp Asp Lys Lys Asp 
    370                 375                 380                 


Gly Asp Val Val Cys Arg Met Leu Gly Phe Arg Gly Val Glu Glu Val 
385                 390                 395                 400 


Tyr Arg Thr Ala Arg Phe Gly Gln Gly Thr Gly Arg Ile Trp Met Asp 
                405                 410                 415     


Asp Val Ala Cys Lys Gly Thr Glu Glu Thr Ile Phe Arg Cys Ser Phe 
            420                 425                 430         


Ser Lys Trp Gly Val Thr Asn Cys Gly His Ala Glu Asp Ala Ser Val 
        435                 440                 445             


Thr Cys Asn Arg His 
    450             


<210>  4
<211>  195
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant protein

<400>  4

Met Gly Ala Ala Ala Arg Thr Leu Arg Leu Ala Leu Gly Leu Leu Leu 
1               5                   10                  15      


Leu Ala Thr Leu Leu Arg Pro Ala Asp Ala Ser Ser Ala Pro His His 
            20                  25                  30          


His His His His Asp Ala Gly Gly Pro Gly Leu Pro Gly Pro Lys Gly 
        35                  40                  45              


Asp Asp Gly Lys Leu Gly Ala Thr Gly Pro Met Gly Met Arg Gly Phe 
    50                  55                  60                  


Lys Gly Asp Arg Gly Pro Lys Gly Glu Lys Gly Glu Lys Gly Asp Arg 
65                  70                  75                  80  


Ala Gly Asp Ala Ser Gly Val Glu Ala Pro Met Met Ile Arg Leu Val 
                85                  90                  95      


Asn Gly Ser Gly Pro His Glu Gly Arg Val Glu Val Tyr His Asp Arg 
            100                 105                 110         


Arg Trp Gly Thr Val Cys Asp Asp Gly Trp Asp Lys Lys Asp Gly Asp 
        115                 120                 125             


Val Val Cys Arg Met Leu Gly Phe Arg Gly Val Glu Glu Val Tyr Arg 
    130                 135                 140                 


Thr Ala Arg Phe Gly Gln Gly Thr Gly Arg Ile Trp Met Asp Asp Val 
145                 150                 155                 160 


Ala Cys Lys Gly Thr Glu Glu Thr Ile Phe Arg Cys Ser Phe Ser Lys 
                165                 170                 175     


Trp Gly Val Thr Asn Cys Gly His Ala Glu Asp Ala Ser Val Thr Cys 
            180                 185                 190         


Asn Arg His 
        195 


<210>  5
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant protein

<400>  5

Met Gly Ala Ala Ala Arg Thr Leu Arg Leu Ala Leu Gly Leu Leu Leu 
1               5                   10                  15      


Leu Ala Thr Leu Leu Arg Pro Ala Asp Ala Ser Ser Ala Pro His His 
            20                  25                  30          


His His His His Asp Ala Gly Gly Arg Pro Arg Ser Ser Pro Asp Asp 
        35                  40                  45              


Leu Lys Ala Leu Thr Arg Asn Val Asn Arg Leu Asn Glu Ser Leu Arg 
    50                  55                  60                  


Asp Met Gln Leu Arg Leu Leu Gln Ala Pro Leu Gln Ala Asp Leu Thr 
65                  70                  75                  80  


Glu Gln Val Trp Lys Val Gln Asp Ala Leu Gln Asn Gln Thr Asp Ser 
                85                  90                  95      


Leu Leu Ala Leu Ala Gly Leu Val Gln Arg Leu Glu Gly Thr Leu Trp 
            100                 105                 110         


Gly Leu His Ala Gln Ala Ala Gln Thr Glu Gln Ala Thr Ala Leu Leu 
        115                 120                 125             


Arg Asp Arg Thr Gly Gln Gln Ser Asp Ser Ala Gln Leu Glu Leu Tyr 
    130                 135                 140                 


Gln Leu Gln Val Glu Ser Asn Arg Ser Gln Leu Leu Leu Gln Arg His 
145                 150                 155                 160 


Ala Gly Leu Leu Asp Gly Leu Ala Arg Arg Val Gly Val Leu Gly Glu 
                165                 170                 175     


Glu Leu Ala Asp Val Gly Gly Ala Leu Arg Gly Leu Asn His Ser Leu 
            180                 185                 190         


Ser Tyr Asp Val Ala Leu His Ser Thr Trp Leu Gln Asp Leu Gln Val 
        195                 200                 205             


Leu Val Ser Asn Ala Ser Ala Asp Thr Arg Arg Met Arg Leu Val His 
    210                 215                 220                 


Met Asp Met Glu Met Gln Leu Lys Gln Glu Leu Ala Thr Leu Asn Val 
225                 230                 235                 240 


Val Thr Glu Asp Leu Arg Leu Lys Asp Trp Glu His Ser Ile Ala Leu 
                245                 250                 255     


Arg Asn Ile Thr Leu Ala Lys Gly Pro Pro Gly Pro Lys Gly Asp Gln 
            260                 265                 270         


Gly Asn Glu Gly Lys Glu Gly Lys Pro Gly Ser Pro Gly Leu Pro Gly 
        275                 280                 285             


Ser Arg Gly Leu Pro Gly Glu Arg Gly Asp Pro Gly Leu Pro Gly Pro 
    290                 295                 300                 


Lys Gly Asp Asp Gly Lys Leu Gly Ala Thr Gly Pro Met Gly Met Arg 
305                 310                 315                 320 


Gly Phe Lys Gly Asp Arg Gly Pro Lys Gly Glu Lys Gly Glu Arg Gly 
                325                 330                 335     


Glu Arg Ala Gly Asp Met Asp Phe Thr Met Ile Arg Leu Val Asn Gly 
            340                 345                 350         


Ser Gly Pro His Gln Gly Arg Val Glu Val Phe His Asp Arg Arg Trp 
        355                 360                 365             


Gly Thr Val Cys Asp Asp Gly Trp Asp Lys Lys Asp Gly Asp Val Val 
    370                 375                 380                 


Cys Arg Met Leu Gly Phe His Gly Val Glu Glu Val Tyr Arg Thr Ala 
385                 390                 395                 400 


Arg Phe Gly Gln Gly Thr Gly Arg Ile Trp Met Asp Asp Val Asn Cys 
                405                 410                 415     


Lys Gly Thr Glu Ser Ser Ile Phe His Cys Gln Phe Ser Lys Trp Gly 
            420                 425                 430         


Val Thr Asn Cys Gly His Ala Glu Asp Ala Gly Val Thr Cys Thr Val 
        435                 440                 445             


Pro 
    


<210>  6
<211>  191
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant protein

<400>  6

Met Gly Ala Ala Ala Arg Thr Leu Arg Leu Ala Leu Gly Leu Leu Leu 
1               5                   10                  15      


Leu Ala Thr Leu Leu Arg Pro Ala Asp Ala Ser Ser Ala Pro His His 
            20                  25                  30          


His His His His Asp Ala Gly Gly Pro Gly Leu Pro Gly Pro Lys Gly 
        35                  40                  45              


Asp Asp Gly Lys Leu Gly Ala Thr Gly Pro Met Gly Met Arg Gly Phe 
    50                  55                  60                  


Lys Gly Asp Arg Gly Pro Lys Gly Glu Lys Gly Glu Arg Gly Glu Arg 
65                  70                  75                  80  


Ala Gly Asp Met Asp Phe Thr Met Ile Arg Leu Val Asn Gly Ser Gly 
                85                  90                  95      


Pro His Gln Gly Arg Val Glu Val Phe His Asp Arg Arg Trp Gly Thr 
            100                 105                 110         


Val Cys Asp Asp Gly Trp Asp Lys Lys Asp Gly Asp Val Val Cys Arg 
        115                 120                 125             


Met Leu Gly Phe His Gly Val Glu Glu Val Tyr Arg Thr Ala Arg Phe 
    130                 135                 140                 


Gly Gln Gly Thr Gly Arg Ile Trp Met Asp Asp Val Asn Cys Lys Gly 
145                 150                 155                 160 


Thr Glu Ser Ser Ile Phe His Cys Gln Phe Ser Lys Trp Gly Val Thr 
                165                 170                 175     


Asn Cys Gly His Ala Glu Asp Ala Gly Val Thr Cys Thr Val Pro 
            180                 185                 190     


<210>  7
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant protein

<400>  7

Met Arg Ala Trp Ile Phe Phe Leu Leu Cys Leu Ala Gly Arg Ala Leu 
1               5                   10                  15      


Ala Ala Pro Leu Ala His His His His His His His His Lys Leu Gln 
            20                  25                  30          


Glu Gln Leu Gln Met Leu Glu Met Cys Cys Gly Asn Gly Ser Leu Ala 
        35                  40                  45              


Ile Glu Asp Lys Pro Phe Phe Ser Leu Gln Trp Ala Pro Lys Thr His 
    50                  55                  60                  


Leu Val Pro Arg Ala Gln Gly Leu Gln Ala Leu Gln Ala Gln Leu Ser 
65                  70                  75                  80  


Trp Val His Thr Ser Gln Glu Gln Leu Arg Gln Gln Phe Asn Asn Leu 
                85                  90                  95      


Thr Gln Asn Pro Glu Leu Phe Gln Ile Lys Gly Glu Arg Gly Ser Pro 
            100                 105                 110         


Gly Pro Lys Gly Ala Pro Gly Ala Pro Gly Ile Pro Gly Leu Pro Gly 
        115                 120                 125             


Pro Ala Ala Glu Lys Gly Glu Lys Gly Ala Ala Gly Arg Asp Gly Thr 
    130                 135                 140                 


Pro Gly Val Gln Gly Pro Gln Gly Pro Pro Gly Ser Lys Gly Glu Ala 
145                 150                 155                 160 


Gly Leu Gln Gly Leu Thr Gly Ala Pro Gly Lys Gln Gly Ala Thr Gly 
                165                 170                 175     


Ala Pro Gly Pro Arg Gly Glu Lys Gly Ser Lys Gly Asp Ile Gly Leu 
            180                 185                 190         


Thr Gly Pro Lys Gly Glu His Gly Thr Lys Gly Asp Lys Gly Asp Leu 
        195                 200                 205             


Gly Leu Pro Gly Asn Lys Gly Asp Met Gly Met Lys Gly Asp Thr Gly 
    210                 215                 220                 


Pro Met Gly Ser Pro Gly Ala Gln Gly Gly Lys Gly Asp Ala Gly Lys 
225                 230                 235                 240 


Pro Gly Leu Pro Gly Leu Ala Gly Ser Pro Gly Val Lys Gly Asp Gln 
                245                 250                 255     


Phe Gln Arg Val Arg Ile Met Gly Gly Thr Asn Arg Gly Arg Ala Glu 
            260                 265                 270         


Val Tyr Tyr Asn Asn Glu Trp Gly Thr Ile Cys Asp Asp Asp Trp Asp 
        275                 280                 285             


Asn Asn Asp Ala Thr Val Phe Cys Arg Met Leu Gly Tyr Ser Arg Gly 
    290                 295                 300                 


Arg Ala Leu Ser Ser Tyr Gly Gly Gly Ser Gly Asn Ile Trp Leu Asp 
305                 310                 315                 320 


Asn Val Asn Cys Arg Gly Thr Glu Asn Ser Leu Trp Asp Cys Ser Lys 
                325                 330                 335     


Asn Ser Trp Gly Asn His Asn Cys Val His Asn Glu Asp Ala Gly Val 
            340                 345                 350         


Glu Cys Ser 
        355 


<210>  8
<211>  370
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant protein

<400>  8

Met Gly Ala Ala Ala Arg Thr Leu Arg Leu Ala Leu Gly Leu Leu Leu 
1               5                   10                  15      


Leu Ala Thr Leu Leu Arg Pro Ala Asp Ala Ser Ser Ala Pro His His 
            20                  25                  30          


His His His His Asp Ala Gly Gly Gln Ala Arg Leu Arg Val Leu Glu 
        35                  40                  45              


Met Tyr Phe Leu Asn Asp Thr Leu Ala Ala Glu Asp Ser Pro Ser Phe 
    50                  55                  60                  


Ser Leu Leu Gln Ser Ala His Pro Gly Glu His Leu Ala Gln Gly Ala 
65                  70                  75                  80  


Ser Arg Leu Gln Val Leu Gln Ala Gln Leu Thr Trp Val Arg Val Ser 
                85                  90                  95      


His Glu His Leu Leu Gln Arg Val Asp Asn Phe Thr Gln Asn Pro Gly 
            100                 105                 110         


Met Phe Arg Ile Lys Gly Glu Gln Gly Ala Pro Gly Leu Gln Gly His 
        115                 120                 125             


Lys Gly Ala Met Gly Met Pro Gly Ala Pro Gly Pro Pro Gly Pro Pro 
    130                 135                 140                 


Ala Glu Lys Gly Ala Lys Gly Ala Met Gly Arg Asp Gly Ala Thr Gly 
145                 150                 155                 160 


Pro Ser Gly Pro Gln Gly Pro Pro Gly Val Lys Gly Glu Ala Gly Leu 
                165                 170                 175     


Gln Gly Pro Gln Gly Ala Pro Gly Lys Gln Gly Ala Thr Gly Thr Pro 
            180                 185                 190         


Gly Pro Gln Gly Glu Lys Gly Ser Lys Gly Asp Gly Gly Leu Ile Gly 
        195                 200                 205             


Pro Lys Gly Glu Thr Gly Thr Lys Gly Glu Lys Gly Asp Leu Gly Leu 
    210                 215                 220                 


Pro Gly Ser Lys Gly Asp Arg Gly Met Lys Gly Asp Ala Gly Val Met 
225                 230                 235                 240 


Gly Pro Pro Gly Ala Gln Gly Ser Lys Gly Asp Phe Gly Arg Pro Gly 
                245                 250                 255     


Pro Pro Gly Leu Ala Gly Phe Pro Gly Ala Lys Gly Asp Gln Ser Val 
            260                 265                 270         


Ser Val Arg Ile Val Gly Ser Ser Asn Arg Gly Arg Ala Glu Val Tyr 
        275                 280                 285             


Tyr Ser Gly Thr Trp Gly Thr Ile Cys Asp Asp Glu Trp Gln Asn Ser 
    290                 295                 300                 


Asp Ala Ile Val Phe Cys Arg Met Leu Gly Tyr Ser Lys Gly Arg Ala 
305                 310                 315                 320 


Leu Tyr Lys Val Gly Ala Gly Thr Gly Gln Ile Trp Leu Asp Asn Val 
                325                 330                 335     


Gln Cys Arg Gly Thr Glu Ser Thr Leu Trp Ser Cys Thr Lys Asn Ser 
            340                 345                 350         


Trp Gly His His Asp Cys Ser His Glu Glu Asp Ala Gly Val Glu Cys 
        355                 360                 365             


Ser Val 
    370 


<210>  9
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant protein

<400>  9

Met Gly Ala Ala Ala Arg Thr Leu Arg Leu Ala Leu Gly Leu Leu Leu 
1               5                   10                  15      


Leu Ala Thr Leu Leu Arg Pro Ala Asp Ala Ser Ser Ala Pro His His 
            20                  25                  30          


His His His His Asp Ala Gly Gly Arg Pro Arg Ser Ser Pro Asp Asp 
        35                  40                  45              


Leu Lys Ala Leu Thr Arg Asn Val Asn Arg Leu Asn Glu Ser Leu Arg 
    50                  55                  60                  


Asp Met Gln Leu Arg Leu Leu Gln Ala Pro Leu Gln Ala Asp Leu Thr 
65                  70                  75                  80  


Glu Gln Val Trp Lys Val Gln Asp Ala Leu Gln Asn Gln Thr Asp Ser 
                85                  90                  95      


Leu Leu Ala Leu Ala Gly Leu Val Gln Arg Leu Glu Gly Thr Leu Trp 
            100                 105                 110         


Gly Leu His Ala Gln Ala Ala Gln Thr Glu Gln Ala Met Ala Leu Leu 
        115                 120                 125             


Arg Asp Arg Thr Gly Gln Gln Ser Asp Ser Ala Gln Leu Glu Leu Tyr 
    130                 135                 140                 


Gln Leu Gln Val Glu Ser Asn Arg Ser Gln Leu Leu Leu Gln Arg His 
145                 150                 155                 160 


Ala Gly Leu Leu Asp Gly Leu Ala Arg Arg Val Gly Val Leu Gly Glu 
                165                 170                 175     


Glu Leu Ala Asp Val Gly Gly Ala Leu Arg Gly Leu Asn His Ser Leu 
            180                 185                 190         


Ser Tyr Asp Val Ala Leu His Ser Thr Trp Leu Gln Asp Leu Gln Val 
        195                 200                 205             


Leu Val Ser Asn Ala Ser Ala Asp Thr Arg Arg Met Arg Leu Val His 
    210                 215                 220                 


Met Asp Met Glu Met Gln Leu Lys Gln Glu Leu Ala Thr Leu Asn Val 
225                 230                 235                 240 


Val Thr Glu Asp Leu Arg Leu Lys Asp Trp Glu His Ser Ile Ala Leu 
                245                 250                 255     


Arg Asn Ile Thr Leu Ala Lys Gly Pro Pro Gly Pro Lys Gly Asp Gln 
            260                 265                 270         


Gly Asn Glu Gly Lys Glu Gly Lys Pro Gly Ser Pro Gly Leu Pro Gly 
        275                 280                 285             


Ser Arg Gly Leu Pro Gly Glu Arg Gly Asp Pro Gly Leu Pro Gly Pro 
    290                 295                 300                 


Lys Gly Asp Asp Gly Lys Leu Gly Ala Thr Gly Pro Met Gly Met Arg 
305                 310                 315                 320 


Gly Phe Lys Gly Asp Arg Gly Pro Lys Gly Glu Lys Gly Glu Arg Gly 
                325                 330                 335     


Glu Arg Gly Gly Ser Thr Pro Leu Lys Thr Val Arg Leu Val Gly Gly 
            340                 345                 350         


Ser Gly Ala His Glu Gly Arg Val Glu Ile Phe His Gln Gly Gln Trp 
        355                 360                 365             


Gly Thr Ile Cys Asp Asp Arg Trp Asp Ile Arg Ala Gly Gln Val Val 
    370                 375                 380                 


Cys Arg Ser Leu Gly Tyr Gln Glu Val Leu Ala Val His Lys Arg Ala 
385                 390                 395                 400 


His Phe Gly Gln Gly Thr Gly Pro Ile Trp Leu Asn Glu Val Met Cys 
                405                 410                 415     


Phe Gly Arg Glu Ser Ser Ile Glu Asn Cys Lys Ile Asn Gln Trp Gly 
            420                 425                 430         


Val Leu Ser Cys Ser His Ser Glu Asp Ala Gly Val Thr Cys Thr Ser 
        435                 440                 445             


<210>  10
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant protein

<400>  10

Met Gly Ala Ala Ala Arg Thr Leu Arg Leu Ala Leu Gly Leu Leu Leu 
1               5                   10                  15      


Leu Ala Thr Leu Leu Arg Pro Ala Asp Ala Ser Ser Ala Pro His His 
            20                  25                  30          


His His His His Asp Ala Gly Gly Arg Pro Arg Ser Ser Pro Asp Asp 
        35                  40                  45              


Leu Lys Ala Leu Thr Arg Asn Val Asn Arg Leu Asn Glu Ser Phe Arg 
    50                  55                  60                  


Asp Leu Gln Leu Arg Leu Leu Gln Ala Pro Leu Gln Ala Asp Leu Thr 
65                  70                  75                  80  


Glu Gln Val Trp Lys Val Gln Asp Ala Leu Gln Asn Gln Ser Asp Ser 
                85                  90                  95      


Leu Leu Ala Leu Ala Gly Ala Val Gln Arg Leu Glu Gly Ala Leu Trp 
            100                 105                 110         


Gly Leu Gln Ala Gln Ala Val Gln Thr Glu Gln Ala Val Ala Leu Leu 
        115                 120                 125             


Arg Asp Arg Thr Gly Gln Gln Ser Asp Thr Ala Gln Leu Glu Leu Tyr 
    130                 135                 140                 


Gln Leu Gln Val Glu Ser Asn Ser Ser Gln Leu Leu Leu Arg Arg His 
145                 150                 155                 160 


Ala Gly Leu Leu Asp Gly Leu Ala Arg Arg Val Gly Ile Leu Gly Glu 
                165                 170                 175     


Glu Leu Ala Asp Val Gly Gly Val Leu Arg Gly Leu Asn His Ser Leu 
            180                 185                 190         


Ser Tyr Asp Val Ala Leu His Arg Thr Arg Leu Gln Asp Leu Arg Val 
        195                 200                 205             


Leu Val Ser Asn Ala Ser Glu Asp Thr Arg Arg Leu Arg Leu Ala His 
    210                 215                 220                 


Val Gly Met Glu Leu Gln Leu Lys Gln Glu Leu Ala Met Leu Asn Ala 
225                 230                 235                 240 


Val Thr Glu Asp Leu Arg Leu Lys Asp Trp Glu His Ser Ile Ala Leu 
                245                 250                 255     


Arg Asn Ile Ser Leu Ala Lys Gly Pro Pro Gly Pro Lys Gly Asp Gln 
            260                 265                 270         


Gly Asp Glu Gly Lys Glu Gly Arg Pro Gly Ile Pro Gly Leu Pro Gly 
        275                 280                 285             


Leu Arg Gly Leu Pro Gly Glu Arg Gly Thr Pro Gly Leu Pro Gly Pro 
    290                 295                 300                 


Lys Gly Asp Asp Gly Lys Leu Gly Ala Thr Gly Pro Met Gly Met Arg 
305                 310                 315                 320 


Gly Phe Lys Gly Asp Arg Gly Pro Lys Gly Glu Lys Gly Glu Lys Gly 
                325                 330                 335     


Asp Arg Asn Thr Leu Thr Pro Phe Thr Lys Val Arg Leu Val Gly Gly 
            340                 345                 350         


Ser Gly Pro His Glu Gly Arg Val Glu Ile Leu His Ser Gly Gln Trp 
        355                 360                 365             


Gly Thr Ile Cys Asp Asp Arg Trp Glu Val Arg Val Gly Gln Val Val 
    370                 375                 380                 


Cys Arg Ser Leu Gly Tyr Pro Gly Val Gln Ala Val His Lys Ala Ala 
385                 390                 395                 400 


His Phe Gly Gln Gly Thr Gly Pro Ile Trp Leu Asn Glu Val Phe Cys 
                405                 410                 415     


Phe Gly Arg Glu Ser Ser Ile Glu Glu Cys Lys Ile Arg Gln Trp Gly 
            420                 425                 430         


Thr Arg Ala Cys Ser His Ser Glu Asp Ala Gly Val Thr Cys Thr Leu 
        435                 440                 445             


<210>  11
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker or affinity tag

<400>  11

Gly Ala Ala Gly Gly 
1               5   


<210>  12
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker or affinity tag

<400>  12

Ala Ala Ala Gly Gly 
1               5   


<210>  13
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker or affinity tag

<400>  13

Asp Ala Gly Gly 
1               


<210>  14
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker or affinity tag

<400>  14

His His Lys 
1           


<210>  15
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Gly Ala Ala Ala Arg Thr Leu Arg Leu Ala Leu Gly Leu Leu Leu 
1               5                   10                  15      


Leu Ala Thr Leu Leu Arg Pro Ala Asp Ala Ser Ser Ala Pro 
            20                  25                  30  


<210>  16
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Arg Ala Trp Ile Phe Phe Leu Leu Cys Leu Ala Gly Arg Ala Leu 
1               5                   10                  15      


Ala Ala Pro Leu Ala 
            20      


<210>  17
<211>  413
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant protein

<400>  17

Arg Pro Arg Ser Ser Pro Asp Asp Leu Lys Ala Leu Thr Arg Asn Val 
1               5                   10                  15      


Asn Arg Leu Asn Glu Ser Phe Arg Asp Leu Gln Leu Arg Leu Leu Gln 
            20                  25                  30          


Ala Pro Leu Gln Ala Asp Leu Thr Glu Gln Val Trp Lys Val Gln Asp 
        35                  40                  45              


Ala Leu Gln Asn Gln Ser Asp Ser Leu Leu Ala Leu Ala Gly Ala Val 
    50                  55                  60                  


Gln Arg Leu Glu Gly Ala Leu Trp Gly Leu Gln Ala Gln Ala Val Gln 
65                  70                  75                  80  


Thr Glu Gln Ala Val Ala Leu Leu Arg Asp Arg Thr Gly Gln Gln Ser 
                85                  90                  95      


Asp Thr Ala Gln Leu Glu Leu Tyr Gln Leu Gln Val Glu Ser Asn Ser 
            100                 105                 110         


Ser Gln Leu Leu Leu Arg Arg His Ala Gly Leu Leu Asp Gly Leu Ala 
        115                 120                 125             


Arg Arg Val Gly Ile Leu Gly Glu Glu Leu Ala Asp Val Gly Gly Val 
    130                 135                 140                 


Leu Arg Gly Leu Asn His Ser Leu Ser Tyr Asp Val Ala Leu His Arg 
145                 150                 155                 160 


Thr Arg Leu Gln Asp Leu Arg Val Leu Val Ser Asn Ala Ser Glu Asp 
                165                 170                 175     


Thr Arg Arg Leu Arg Leu Ala His Val Gly Met Glu Leu Gln Leu Lys 
            180                 185                 190         


Gln Glu Leu Ala Met Leu Asn Ala Val Thr Glu Asp Leu Arg Leu Lys 
        195                 200                 205             


Asp Trp Glu His Ser Ile Ala Leu Arg Asn Ile Ser Leu Ala Lys Gly 
    210                 215                 220                 


Pro Pro Gly Pro Lys Gly Asp Gln Gly Asp Glu Gly Lys Glu Gly Arg 
225                 230                 235                 240 


Pro Gly Ile Pro Gly Leu Pro Gly Leu Arg Gly Leu Pro Gly Glu Arg 
                245                 250                 255     


Gly Thr Pro Gly Leu Pro Gly Pro Lys Gly Asp Asp Gly Lys Leu Gly 
            260                 265                 270         


Ala Thr Gly Pro Met Gly Met Arg Gly Phe Lys Gly Asp Arg Gly Pro 
        275                 280                 285             


Lys Gly Glu Lys Gly Glu Lys Gly Asp Arg Ala Gly Asp Ala Ser Gly 
    290                 295                 300                 


Val Glu Ala Pro Met Met Ile Arg Leu Val Asn Gly Ser Gly Pro His 
305                 310                 315                 320 


Glu Gly Arg Val Glu Val Tyr His Asp Arg Arg Trp Gly Thr Val Cys 
                325                 330                 335     


Asp Asp Gly Trp Asp Lys Lys Asp Gly Asp Val Val Cys Arg Met Leu 
            340                 345                 350         


Gly Phe Arg Gly Val Glu Glu Val Tyr Arg Thr Ala Arg Phe Gly Gln 
        355                 360                 365             


Gly Thr Gly Arg Ile Trp Met Asp Asp Val Ala Cys Lys Gly Thr Glu 
    370                 375                 380                 


Glu Thr Ile Phe Arg Cys Ser Phe Ser Lys Trp Gly Val Thr Asn Cys 
385                 390                 395                 400 


Gly His Ala Glu Asp Ala Ser Val Thr Cys Asn Arg His 
                405                 410             


<210>  18
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant protein

<400>  18

Pro Gly Leu Pro Gly Pro Lys Gly Asp Asp Gly Lys Leu Gly Ala Thr 
1               5                   10                  15      


Gly Pro Met Gly Met Arg Gly Phe Lys Gly Asp Arg Gly Pro Lys Gly 
            20                  25                  30          


Glu Lys Gly Glu Lys Gly Asp Arg Ala Gly Asp Ala Ser Gly Val Glu 
        35                  40                  45              


Ala Pro Met Met Ile Arg Leu Val Asn Gly Ser Gly Pro His Glu Gly 
    50                  55                  60                  


Arg Val Glu Val Tyr His Asp Arg Arg Trp Gly Thr Val Cys Asp Asp 
65                  70                  75                  80  


Gly Trp Asp Lys Lys Asp Gly Asp Val Val Cys Arg Met Leu Gly Phe 
                85                  90                  95      


Arg Gly Val Glu Glu Val Tyr Arg Thr Ala Arg Phe Gly Gln Gly Thr 
            100                 105                 110         


Gly Arg Ile Trp Met Asp Asp Val Ala Cys Lys Gly Thr Glu Glu Thr 
        115                 120                 125             


Ile Phe Arg Cys Ser Phe Ser Lys Trp Gly Val Thr Asn Cys Gly His 
    130                 135                 140                 


Ala Glu Asp Ala Ser Val Thr Cys Asn Arg His 
145                 150                 155 


<210>  19
<211>  409
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant protein

<400>  19

Arg Pro Arg Ser Ser Pro Asp Asp Leu Lys Ala Leu Thr Arg Asn Val 
1               5                   10                  15      


Asn Arg Leu Asn Glu Ser Leu Arg Asp Met Gln Leu Arg Leu Leu Gln 
            20                  25                  30          


Ala Pro Leu Gln Ala Asp Leu Thr Glu Gln Val Trp Lys Val Gln Asp 
        35                  40                  45              


Ala Leu Gln Asn Gln Thr Asp Ser Leu Leu Ala Leu Ala Gly Leu Val 
    50                  55                  60                  


Gln Arg Leu Glu Gly Thr Leu Trp Gly Leu His Ala Gln Ala Ala Gln 
65                  70                  75                  80  


Thr Glu Gln Ala Thr Ala Leu Leu Arg Asp Arg Thr Gly Gln Gln Ser 
                85                  90                  95      


Asp Ser Ala Gln Leu Glu Leu Tyr Gln Leu Gln Val Glu Ser Asn Arg 
            100                 105                 110         


Ser Gln Leu Leu Leu Gln Arg His Ala Gly Leu Leu Asp Gly Leu Ala 
        115                 120                 125             


Arg Arg Val Gly Val Leu Gly Glu Glu Leu Ala Asp Val Gly Gly Ala 
    130                 135                 140                 


Leu Arg Gly Leu Asn His Ser Leu Ser Tyr Asp Val Ala Leu His Ser 
145                 150                 155                 160 


Thr Trp Leu Gln Asp Leu Gln Val Leu Val Ser Asn Ala Ser Ala Asp 
                165                 170                 175     


Thr Arg Arg Met Arg Leu Val His Met Asp Met Glu Met Gln Leu Lys 
            180                 185                 190         


Gln Glu Leu Ala Thr Leu Asn Val Val Thr Glu Asp Leu Arg Leu Lys 
        195                 200                 205             


Asp Trp Glu His Ser Ile Ala Leu Arg Asn Ile Thr Leu Ala Lys Gly 
    210                 215                 220                 


Pro Pro Gly Pro Lys Gly Asp Gln Gly Asn Glu Gly Lys Glu Gly Lys 
225                 230                 235                 240 


Pro Gly Ser Pro Gly Leu Pro Gly Ser Arg Gly Leu Pro Gly Glu Arg 
                245                 250                 255     


Gly Asp Pro Gly Leu Pro Gly Pro Lys Gly Asp Asp Gly Lys Leu Gly 
            260                 265                 270         


Ala Thr Gly Pro Met Gly Met Arg Gly Phe Lys Gly Asp Arg Gly Pro 
        275                 280                 285             


Lys Gly Glu Lys Gly Glu Arg Gly Glu Arg Ala Gly Asp Met Asp Phe 
    290                 295                 300                 


Thr Met Ile Arg Leu Val Asn Gly Ser Gly Pro His Gln Gly Arg Val 
305                 310                 315                 320 


Glu Val Phe His Asp Arg Arg Trp Gly Thr Val Cys Asp Asp Gly Trp 
                325                 330                 335     


Asp Lys Lys Asp Gly Asp Val Val Cys Arg Met Leu Gly Phe His Gly 
            340                 345                 350         


Val Glu Glu Val Tyr Arg Thr Ala Arg Phe Gly Gln Gly Thr Gly Arg 
        355                 360                 365             


Ile Trp Met Asp Asp Val Asn Cys Lys Gly Thr Glu Ser Ser Ile Phe 
    370                 375                 380                 


His Cys Gln Phe Ser Lys Trp Gly Val Thr Asn Cys Gly His Ala Glu 
385                 390                 395                 400 


Asp Ala Gly Val Thr Cys Thr Val Pro 
                405                 


<210>  20
<211>  151
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant protein

<400>  20

Pro Gly Leu Pro Gly Pro Lys Gly Asp Asp Gly Lys Leu Gly Ala Thr 
1               5                   10                  15      


Gly Pro Met Gly Met Arg Gly Phe Lys Gly Asp Arg Gly Pro Lys Gly 
            20                  25                  30          


Glu Lys Gly Glu Arg Gly Glu Arg Ala Gly Asp Met Asp Phe Thr Met 
        35                  40                  45              


Ile Arg Leu Val Asn Gly Ser Gly Pro His Gln Gly Arg Val Glu Val 
    50                  55                  60                  


Phe His Asp Arg Arg Trp Gly Thr Val Cys Asp Asp Gly Trp Asp Lys 
65                  70                  75                  80  


Lys Asp Gly Asp Val Val Cys Arg Met Leu Gly Phe His Gly Val Glu 
                85                  90                  95      


Glu Val Tyr Arg Thr Ala Arg Phe Gly Gln Gly Thr Gly Arg Ile Trp 
            100                 105                 110         


Met Asp Asp Val Asn Cys Lys Gly Thr Glu Ser Ser Ile Phe His Cys 
        115                 120                 125             


Gln Phe Ser Lys Trp Gly Val Thr Asn Cys Gly His Ala Glu Asp Ala 
    130                 135                 140                 


Gly Val Thr Cys Thr Val Pro 
145                 150     


<210>  21
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant protein

<400>  21

Leu Gln Glu Gln Leu Gln Met Leu Glu Met Cys Cys Gly Asn Gly Ser 
1               5                   10                  15      


Leu Ala Ile Glu Asp Lys Pro Phe Phe Ser Leu Gln Trp Ala Pro Lys 
            20                  25                  30          


Thr His Leu Val Pro Arg Ala Gln Gly Leu Gln Ala Leu Gln Ala Gln 
        35                  40                  45              


Leu Ser Trp Val His Thr Ser Gln Glu Gln Leu Arg Gln Gln Phe Asn 
    50                  55                  60                  


Asn Leu Thr Gln Asn Pro Glu Leu Phe Gln Ile Lys Gly Glu Arg Gly 
65                  70                  75                  80  


Ser Pro Gly Pro Lys Gly Ala Pro Gly Ala Pro Gly Ile Pro Gly Leu 
                85                  90                  95      


Pro Gly Pro Ala Ala Glu Lys Gly Glu Lys Gly Ala Ala Gly Arg Asp 
            100                 105                 110         


Gly Thr Pro Gly Val Gln Gly Pro Gln Gly Pro Pro Gly Ser Lys Gly 
        115                 120                 125             


Glu Ala Gly Leu Gln Gly Leu Thr Gly Ala Pro Gly Lys Gln Gly Ala 
    130                 135                 140                 


Thr Gly Ala Pro Gly Pro Arg Gly Glu Lys Gly Ser Lys Gly Asp Ile 
145                 150                 155                 160 


Gly Leu Thr Gly Pro Lys Gly Glu His Gly Thr Lys Gly Asp Lys Gly 
                165                 170                 175     


Asp Leu Gly Leu Pro Gly Asn Lys Gly Asp Met Gly Met Lys Gly Asp 
            180                 185                 190         


Thr Gly Pro Met Gly Ser Pro Gly Ala Gln Gly Gly Lys Gly Asp Ala 
        195                 200                 205             


Gly Lys Pro Gly Leu Pro Gly Leu Ala Gly Ser Pro Gly Val Lys Gly 
    210                 215                 220                 


Asp Gln Phe Gln Arg Val Arg Ile Met Gly Gly Thr Asn Arg Gly Arg 
225                 230                 235                 240 


Ala Glu Val Tyr Tyr Asn Asn Glu Trp Gly Thr Ile Cys Asp Asp Asp 
                245                 250                 255     


Trp Asp Asn Asn Asp Ala Thr Val Phe Cys Arg Met Leu Gly Tyr Ser 
            260                 265                 270         


Arg Gly Arg Ala Leu Ser Ser Tyr Gly Gly Gly Ser Gly Asn Ile Trp 
        275                 280                 285             


Leu Asp Asn Val Asn Cys Arg Gly Thr Glu Asn Ser Leu Trp Asp Cys 
    290                 295                 300                 


Ser Lys Asn Ser Trp Gly Asn His Asn Cys Val His Asn Glu Asp Ala 
305                 310                 315                 320 


Gly Val Glu Cys Ser 
                325 


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker or affinity tag

<400>  22

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  23
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker or affinity tag

<400>  23

Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
1               5                   10                  


<210>  24
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker or affinity tag

<400>  24

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  25
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker or affinity tag

<400>  25

Asp Tyr Lys Asp Asp Asp Asp Lys Gly 
1               5                   


<210>  26
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker or affinity tag

<400>  26

Gln Pro Glu Leu Ala Pro Glu Asp Pro Glu Asp 
1               5                   10      


<210>  27
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker or affinity tag

<400>  27

Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
1               5                   10      


<210>  28
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker or affinity tag

<400>  28

His His His His His His 
1               5       


<210>  29
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker or affinity tag

<400>  29

Ala Ser Met Thr Gly Gly Gln Gln Met Gly Arg 
1               5                   10      


<210>  30
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker or affinity tag

<400>  30

Gly Ala Gly Thr Pro Val Thr Ala Pro Leu Ala Gly Thr Ile Trp Lys 
1               5                   10                  15      


Val Leu Ser Glu Gly Gln Thr Val Ala Ala Gly Glu Val Leu Leu Ile 
            20                  25                  30          


Leu Glu Ala Met Lys Glu Thr Glu Ile Arg Ala Ala Gln Ala Gly Thr 
        35                  40                  45              


Val Arg Gly Ile Ala Val Lys Ala Gly Asp Ala Val Ala Val Gly Asp 
    50                  55                  60                  


Thr Leu Met Thr Leu Ala 
65                  70  


<210>  31
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker or affinity tag

<400>  31

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  32
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant protein

<400>  32

Gln Ala Arg Leu Arg Val Leu Glu Met Tyr Phe Leu Asn Asp Thr Leu 
1               5                   10                  15      


Ala Ala Glu Asp Ser Pro Ser Phe Ser Leu Leu Gln Ser Ala His Pro 
            20                  25                  30          


Gly Glu His Leu Ala Gln Gly Ala Ser Arg Leu Gln Val Leu Gln Ala 
        35                  40                  45              


Gln Leu Thr Trp Val Arg Val Ser His Glu His Leu Leu Gln Arg Val 
    50                  55                  60                  


Asp Asn Phe Thr Gln Asn Pro Gly Met Phe Arg Ile Lys Gly Glu Gln 
65                  70                  75                  80  


Gly Ala Pro Gly Leu Gln Gly His Lys Gly Ala Met Gly Met Pro Gly 
                85                  90                  95      


Ala Pro Gly Pro Pro Gly Pro Pro Ala Glu Lys Gly Ala Lys Gly Ala 
            100                 105                 110         


Met Gly Arg Asp Gly Ala Thr Gly Pro Ser Gly Pro Gln Gly Pro Pro 
        115                 120                 125             


Gly Val Lys Gly Glu Ala Gly Leu Gln Gly Pro Gln Gly Ala Pro Gly 
    130                 135                 140                 


Lys Gln Gly Ala Thr Gly Thr Pro Gly Pro Gln Gly Glu Lys Gly Ser 
145                 150                 155                 160 


Lys Gly Asp Gly Gly Leu Ile Gly Pro Lys Gly Glu Thr Gly Thr Lys 
                165                 170                 175     


Gly Glu Lys Gly Asp Leu Gly Leu Pro Gly Ser Lys Gly Asp Arg Gly 
            180                 185                 190         


Met Lys Gly Asp Ala Gly Val Met Gly Pro Pro Gly Ala Gln Gly Ser 
        195                 200                 205             


Lys Gly Asp Phe Gly Arg Pro Gly Pro Pro Gly Leu Ala Gly Phe Pro 
    210                 215                 220                 


Gly Ala Lys Gly Asp Gln Ser Val Ser Val Arg Ile Val Gly Ser Ser 
225                 230                 235                 240 


Asn Arg Gly Arg Ala Glu Val Tyr Tyr Ser Gly Thr Trp Gly Thr Ile 
                245                 250                 255     


Cys Asp Asp Glu Trp Gln Asn Ser Asp Ala Ile Val Phe Cys Arg Met 
            260                 265                 270         


Leu Gly Tyr Ser Lys Gly Arg Ala Leu Tyr Lys Val Gly Ala Gly Thr 
        275                 280                 285             


Gly Gln Ile Trp Leu Asp Asn Val Gln Cys Arg Gly Thr Glu Ser Thr 
    290                 295                 300                 


Leu Trp Ser Cys Thr Lys Asn Ser Trp Gly His His Asp Cys Ser His 
305                 310                 315                 320 


Glu Glu Asp Ala Gly Val Glu Cys Ser Val 
                325                 330 


<210>  33
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant protein

<400>  33

Arg Pro Arg Ser Ser Pro Asp Asp Leu Lys Ala Leu Thr Arg Asn Val 
1               5                   10                  15      


Asn Arg Leu Asn Glu Ser Leu Arg Asp Met Gln Leu Arg Leu Leu Gln 
            20                  25                  30          


Ala Pro Leu Gln Ala Asp Leu Thr Glu Gln Val Trp Lys Val Gln Asp 
        35                  40                  45              


Ala Leu Gln Asn Gln Thr Asp Ser Leu Leu Ala Leu Ala Gly Leu Val 
    50                  55                  60                  


Gln Arg Leu Glu Gly Thr Leu Trp Gly Leu His Ala Gln Ala Ala Gln 
65                  70                  75                  80  


Thr Glu Gln Ala Met Ala Leu Leu Arg Asp Arg Thr Gly Gln Gln Ser 
                85                  90                  95      


Asp Ser Ala Gln Leu Glu Leu Tyr Gln Leu Gln Val Glu Ser Asn Arg 
            100                 105                 110         


Ser Gln Leu Leu Leu Gln Arg His Ala Gly Leu Leu Asp Gly Leu Ala 
        115                 120                 125             


Arg Arg Val Gly Val Leu Gly Glu Glu Leu Ala Asp Val Gly Gly Ala 
    130                 135                 140                 


Leu Arg Gly Leu Asn His Ser Leu Ser Tyr Asp Val Ala Leu His Ser 
145                 150                 155                 160 


Thr Trp Leu Gln Asp Leu Gln Val Leu Val Ser Asn Ala Ser Ala Asp 
                165                 170                 175     


Thr Arg Arg Met Arg Leu Val His Met Asp Met Glu Met Gln Leu Lys 
            180                 185                 190         


Gln Glu Leu Ala Thr Leu Asn Val Val Thr Glu Asp Leu Arg Leu Lys 
        195                 200                 205             


Asp Trp Glu His Ser Ile Ala Leu Arg Asn Ile Thr Leu Ala Lys Gly 
    210                 215                 220                 


Pro Pro Gly Pro Lys Gly Asp Gln Gly Asn Glu Gly Lys Glu Gly Lys 
225                 230                 235                 240 


Pro Gly Ser Pro Gly Leu Pro Gly Ser Arg Gly Leu Pro Gly Glu Arg 
                245                 250                 255     


Gly Asp Pro Gly Leu Pro Gly Pro Lys Gly Asp Asp Gly Lys Leu Gly 
            260                 265                 270         


Ala Thr Gly Pro Met Gly Met Arg Gly Phe Lys Gly Asp Arg Gly Pro 
        275                 280                 285             


Lys Gly Glu Lys Gly Glu Arg Gly Glu Arg Gly Gly Ser Thr Pro Leu 
    290                 295                 300                 


Lys Thr Val Arg Leu Val Gly Gly Ser Gly Ala His Glu Gly Arg Val 
305                 310                 315                 320 


Glu Ile Phe His Gln Gly Gln Trp Gly Thr Ile Cys Asp Asp Arg Trp 
                325                 330                 335     


Asp Ile Arg Ala Gly Gln Val Val Cys Arg Ser Leu Gly Tyr Gln Glu 
            340                 345                 350         


Val Leu Ala Val His Lys Arg Ala His Phe Gly Gln Gly Thr Gly Pro 
        355                 360                 365             


Ile Trp Leu Asn Glu Val Met Cys Phe Gly Arg Glu Ser Ser Ile Glu 
    370                 375                 380                 


Asn Cys Lys Ile Asn Gln Trp Gly Val Leu Ser Cys Ser His Ser Glu 
385                 390                 395                 400 


Asp Ala Gly Val Thr Cys Thr Ser 
                405             


<210>  34
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant protein

<400>  34

Arg Pro Arg Ser Ser Pro Asp Asp Leu Lys Ala Leu Thr Arg Asn Val 
1               5                   10                  15      


Asn Arg Leu Asn Glu Ser Phe Arg Asp Leu Gln Leu Arg Leu Leu Gln 
            20                  25                  30          


Ala Pro Leu Gln Ala Asp Leu Thr Glu Gln Val Trp Lys Val Gln Asp 
        35                  40                  45              


Ala Leu Gln Asn Gln Ser Asp Ser Leu Leu Ala Leu Ala Gly Ala Val 
    50                  55                  60                  


Gln Arg Leu Glu Gly Ala Leu Trp Gly Leu Gln Ala Gln Ala Val Gln 
65                  70                  75                  80  


Thr Glu Gln Ala Val Ala Leu Leu Arg Asp Arg Thr Gly Gln Gln Ser 
                85                  90                  95      


Asp Thr Ala Gln Leu Glu Leu Tyr Gln Leu Gln Val Glu Ser Asn Ser 
            100                 105                 110         


Ser Gln Leu Leu Leu Arg Arg His Ala Gly Leu Leu Asp Gly Leu Ala 
        115                 120                 125             


Arg Arg Val Gly Ile Leu Gly Glu Glu Leu Ala Asp Val Gly Gly Val 
    130                 135                 140                 


Leu Arg Gly Leu Asn His Ser Leu Ser Tyr Asp Val Ala Leu His Arg 
145                 150                 155                 160 


Thr Arg Leu Gln Asp Leu Arg Val Leu Val Ser Asn Ala Ser Glu Asp 
                165                 170                 175     


Thr Arg Arg Leu Arg Leu Ala His Val Gly Met Glu Leu Gln Leu Lys 
            180                 185                 190         


Gln Glu Leu Ala Met Leu Asn Ala Val Thr Glu Asp Leu Arg Leu Lys 
        195                 200                 205             


Asp Trp Glu His Ser Ile Ala Leu Arg Asn Ile Ser Leu Ala Lys Gly 
    210                 215                 220                 


Pro Pro Gly Pro Lys Gly Asp Gln Gly Asp Glu Gly Lys Glu Gly Arg 
225                 230                 235                 240 


Pro Gly Ile Pro Gly Leu Pro Gly Leu Arg Gly Leu Pro Gly Glu Arg 
                245                 250                 255     


Gly Thr Pro Gly Leu Pro Gly Pro Lys Gly Asp Asp Gly Lys Leu Gly 
            260                 265                 270         


Ala Thr Gly Pro Met Gly Met Arg Gly Phe Lys Gly Asp Arg Gly Pro 
        275                 280                 285             


Lys Gly Glu Lys Gly Glu Lys Gly Asp Arg Asn Thr Leu Thr Pro Phe 
    290                 295                 300                 


Thr Lys Val Arg Leu Val Gly Gly Ser Gly Pro His Glu Gly Arg Val 
305                 310                 315                 320 


Glu Ile Leu His Ser Gly Gln Trp Gly Thr Ile Cys Asp Asp Arg Trp 
                325                 330                 335     


Glu Val Arg Val Gly Gln Val Val Cys Arg Ser Leu Gly Tyr Pro Gly 
            340                 345                 350         


Val Gln Ala Val His Lys Ala Ala His Phe Gly Gln Gly Thr Gly Pro 
        355                 360                 365             


Ile Trp Leu Asn Glu Val Phe Cys Phe Gly Arg Glu Ser Ser Ile Glu 
    370                 375                 380                 


Glu Cys Lys Ile Arg Gln Trp Gly Thr Arg Ala Cys Ser His Ser Glu 
385                 390                 395                 400 


Asp Ala Gly Val Thr Cys Thr Leu 
                405             


<210>  35
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker or affinity tag

<400>  35

Met Gly Ala Ala Ala Arg Thr Leu Arg Leu Ala Leu Gly Leu Leu Leu 
1               5                   10                  15      


Leu Ala Thr Leu Leu Arg Pro Ala Asp Ala Ser Ser Ala Pro His His 
            20                  25                  30          


His His His His His His Ser Gly Gly Leu Asn Asp Ile Phe Glu Ala 
        35                  40                  45              


Gln Lys Ile Glu Trp His Glu Ser Gly Arg Pro Arg Ser Ser Pro Asp 
    50                  55                  60                  


Asp Leu Lys Ala Leu Thr Arg Asn Val Asn Arg Leu Asn Glu Ser Phe 
65                  70                  75                  80  


Arg Asp Leu Gln Leu Arg Leu Leu Gln Ala Pro Leu Gln Ala Asp Leu 
                85                  90                  95      


Thr Glu Gln Val Trp Lys Val Gln Asp Ala Leu Gln Asn Gln Ser Asp 
            100                 105                 110         


Ser Leu Leu Ala Leu Ala Gly Ala Val Gln Arg Leu Glu Gly Ala Leu 
        115                 120                 125             


Trp Gly Leu Gln Ala Gln Ala Val Gln Thr Glu Gln Ala Val Ala Leu 
    130                 135                 140                 


Leu Arg Asp Arg Thr Gly Gln Gln Ser Asp Thr Ala Gln Leu Glu Leu 
145                 150                 155                 160 


Tyr Gln Leu Gln Val Glu Ser Asn Ser Ser Gln Leu Leu Leu Arg Arg 
                165                 170                 175     


His Ala Gly Leu Leu Asp Gly Leu Ala Arg Arg Val Gly Ile Leu Gly 
            180                 185                 190         


Glu Glu Leu Ala Asp Val Gly Gly Val Leu Arg Gly Leu Asn His Ser 
        195                 200                 205             


Leu Ser Tyr Asp Val Ala Leu His Arg Thr Arg Leu Gln Asp Leu Arg 
    210                 215                 220                 


Val Leu Val Ser Asn Ala Ser Glu Asp Thr Arg Arg Leu Arg Leu Ala 
225                 230                 235                 240 


His Val Gly Met Glu Leu Gln Leu Lys Gln Glu Leu Ala Met Leu Asn 
                245                 250                 255     


Ala Val Thr Glu Asp Leu Arg Leu Lys Asp Trp Glu His Ser Ile Ala 
            260                 265                 270         


Leu Arg Asn Ile Ser Leu Ala Lys Gly Pro Pro Gly Pro Lys Gly Asp 
        275                 280                 285             


Gln Gly Asp Glu Gly Lys Glu Gly Arg Pro Gly Ile Pro Gly Leu Pro 
    290                 295                 300                 


Gly Leu Arg Gly Leu Pro Gly Glu Arg Gly Thr Pro Gly Leu Pro Gly 
305                 310                 315                 320 


Pro Lys Gly Asp Asp Gly Lys Leu Gly Ala Thr Gly Pro Met Gly Met 
                325                 330                 335     


Arg Gly Phe Lys Gly Asp Arg Gly Pro Lys Gly Glu Lys Gly Glu Lys 
            340                 345                 350         


Gly Asp Arg Ala Gly Asp Ala Ser Gly Val Glu Ala Pro Met Met Ile 
        355                 360                 365             


Arg Leu Val Asn Gly Ser Gly Pro His Glu Gly Arg Val Glu Val Tyr 
    370                 375                 380                 


His Asp Arg Arg Trp Gly Thr Val Cys Asp Asp Gly Trp Asp Lys Lys 
385                 390                 395                 400 


Asp Gly Asp Val Val Cys Arg Met Leu Gly Phe Arg Gly Val Glu Glu 
                405                 410                 415     


Val Tyr Arg Thr Ala Arg Phe Gly Gln Gly Thr Gly Arg Ile Trp Met 
            420                 425                 430         


Asp Asp Val Ala Cys Lys Gly Thr Glu Glu Thr Ile Phe Arg Cys Ser 
        435                 440                 445             


Phe Ser Lys Trp Gly Val Thr Asn Cys Gly His Ala Glu Asp Ala Ser 
    450                 455                 460                 


Val Thr Cys Asn Arg His 
465                 470 


<210>  36
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant protein

<400>  36

Met Gly Ala Ala Ala Arg Thr Leu Arg Leu Ala Leu Gly Leu Leu Leu 
1               5                   10                  15      


Leu Ala Thr Leu Leu Arg Pro Ala Asp Ala Ser Ser Ala Ala Trp Arg 
            20                  25                  30          


His Pro Gln Phe Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
        35                  40                  45              


Ala Trp Arg His Pro Gln Phe Gly Gly Ser Gly His His His His His 
    50                  55                  60                  


His His His Arg Pro Arg Ser Ser Pro Asp Asp Leu Lys Ala Leu Thr 
65                  70                  75                  80  


Arg Asn Val Asn Arg Leu Asn Glu Ser Phe Arg Asp Leu Gln Leu Arg 
                85                  90                  95      


Leu Leu Gln Ala Pro Leu Gln Ala Asp Leu Thr Glu Gln Val Trp Lys 
            100                 105                 110         


Val Gln Asp Ala Leu Gln Asn Gln Ser Asp Ser Leu Leu Ala Leu Ala 
        115                 120                 125             


Gly Ala Val Gln Arg Leu Glu Gly Ala Leu Trp Gly Leu Gln Ala Gln 
    130                 135                 140                 


Ala Val Gln Thr Glu Gln Ala Val Ala Leu Leu Arg Asp Arg Thr Gly 
145                 150                 155                 160 


Gln Gln Ser Asp Thr Ala Gln Leu Glu Leu Tyr Gln Leu Gln Val Glu 
                165                 170                 175     


Ser Asn Ser Ser Gln Leu Leu Leu Arg Arg His Ala Gly Leu Leu Asp 
            180                 185                 190         


Gly Leu Ala Arg Arg Val Gly Ile Leu Gly Glu Glu Leu Ala Asp Val 
        195                 200                 205             


Gly Gly Val Leu Arg Gly Leu Asn His Ser Leu Ser Tyr Asp Val Ala 
    210                 215                 220                 


Leu His Arg Thr Arg Leu Gln Asp Leu Arg Val Leu Val Ser Asn Ala 
225                 230                 235                 240 


Ser Glu Asp Thr Arg Arg Leu Arg Leu Ala His Val Gly Met Glu Leu 
                245                 250                 255     


Gln Leu Lys Gln Glu Leu Ala Met Leu Asn Ala Val Thr Glu Asp Leu 
            260                 265                 270         


Arg Leu Lys Asp Trp Glu His Ser Ile Ala Leu Arg Asn Ile Ser Leu 
        275                 280                 285             


Ala Lys Gly Pro Pro Gly Pro Lys Gly Asp Gln Gly Asp Glu Gly Lys 
    290                 295                 300                 


Glu Gly Arg Pro Gly Ile Pro Gly Leu Pro Gly Leu Arg Gly Leu Pro 
305                 310                 315                 320 


Gly Glu Arg Gly Thr Pro Gly Leu Pro Gly Pro Lys Gly Asp Asp Gly 
                325                 330                 335     


Lys Leu Gly Ala Thr Gly Pro Met Gly Met Arg Gly Phe Lys Gly Asp 
            340                 345                 350         


Arg Gly Pro Lys Gly Glu Lys Gly Glu Lys Gly Asp Arg Ala Gly Asp 
        355                 360                 365             


Ala Ser Gly Val Glu Ala Pro Met Met Ile Arg Leu Val Asn Gly Ser 
    370                 375                 380                 


Gly Pro His Glu Gly Arg Val Glu Val Tyr His Asp Arg Arg Trp Gly 
385                 390                 395                 400 


Thr Val Cys Asp Asp Gly Trp Asp Lys Lys Asp Gly Asp Val Val Cys 
                405                 410                 415     


Arg Met Leu Gly Phe Arg Gly Val Glu Glu Val Tyr Arg Thr Ala Arg 
            420                 425                 430         


Phe Gly Gln Gly Thr Gly Arg Ile Trp Met Asp Asp Val Ala Cys Lys 
        435                 440                 445             


Gly Thr Glu Glu Thr Ile Phe Arg Cys Ser Phe Ser Lys Trp Gly Val 
    450                 455                 460                 


Thr Asn Cys Gly His Ala Glu Asp Ala Ser Val Thr Cys Asn Arg His 
465                 470                 475                 480 


<210>  37
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant protein

<400>  37

Met Gly Ala Ala Ala Arg Thr Leu Arg Leu Ala Leu Gly Leu Leu Leu 
1               5                   10                  15      


Leu Ala Thr Leu Leu Arg Pro Ala Asp Ala Ser Ser Ala Pro His His 
            20                  25                  30          


His His His His His His Ser Gly Gly Leu Asn Asp Ile Phe Glu Ala 
        35                  40                  45              


Gln Lys Ile Glu Trp His Glu Ser Gly Gln Ala Arg Leu Arg Val Leu 
    50                  55                  60                  


Glu Met Tyr Phe Leu Asn Asp Thr Leu Ala Ala Glu Asp Ser Pro Ser 
65                  70                  75                  80  


Phe Ser Leu Leu Gln Ser Ala His Pro Gly Glu His Leu Ala Gln Gly 
                85                  90                  95      


Ala Ser Arg Leu Gln Val Leu Gln Ala Gln Leu Thr Trp Val Arg Val 
            100                 105                 110         


Ser His Glu His Leu Leu Gln Arg Val Asp Asn Phe Thr Gln Asn Pro 
        115                 120                 125             


Gly Met Phe Arg Ile Lys Gly Glu Gln Gly Ala Pro Gly Leu Gln Gly 
    130                 135                 140                 


His Lys Gly Ala Met Gly Met Pro Gly Ala Pro Gly Pro Pro Gly Pro 
145                 150                 155                 160 


Pro Ala Glu Lys Gly Ala Lys Gly Ala Met Gly Arg Asp Gly Ala Thr 
                165                 170                 175     


Gly Pro Ser Gly Pro Gln Gly Pro Pro Gly Val Lys Gly Glu Ala Gly 
            180                 185                 190         


Leu Gln Gly Pro Gln Gly Ala Pro Gly Lys Gln Gly Ala Thr Gly Thr 
        195                 200                 205             


Pro Gly Pro Gln Gly Glu Lys Gly Ser Lys Gly Asp Gly Gly Leu Ile 
    210                 215                 220                 


Gly Pro Lys Gly Glu Thr Gly Thr Lys Gly Glu Lys Gly Asp Leu Gly 
225                 230                 235                 240 


Leu Pro Gly Ser Lys Gly Asp Arg Gly Met Lys Gly Asp Ala Gly Val 
                245                 250                 255     


Met Gly Pro Pro Gly Ala Gln Gly Ser Lys Gly Asp Phe Gly Arg Pro 
            260                 265                 270         


Gly Pro Pro Gly Leu Ala Gly Phe Pro Gly Ala Lys Gly Asp Gln Ser 
        275                 280                 285             


Val Ser Val Arg Ile Val Gly Ser Ser Asn Arg Gly Arg Ala Glu Val 
    290                 295                 300                 


Tyr Tyr Ser Gly Thr Trp Gly Thr Ile Cys Asp Asp Glu Trp Gln Asn 
305                 310                 315                 320 


Ser Asp Ala Ile Val Phe Cys Arg Met Leu Gly Tyr Ser Lys Gly Arg 
                325                 330                 335     


Ala Leu Tyr Lys Val Gly Ala Gly Thr Gly Gln Ile Trp Leu Asp Asn 
            340                 345                 350         


Val Gln Cys Arg Gly Thr Glu Ser Thr Leu Trp Ser Cys Thr Lys Asn 
        355                 360                 365             


Ser Trp Gly His His Asp Cys Ser His Glu Glu Asp Ala Gly Val Glu 
    370                 375                 380                 


Cys Ser Val 
385         


<210>  38
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant protein

<400>  38

Met Gly Ala Ala Ala Arg Thr Leu Arg Leu Ala Leu Gly Leu Leu Leu 
1               5                   10                  15      


Leu Ala Thr Leu Leu Arg Pro Ala Asp Ala Ser Ser Ala Ala Trp Arg 
            20                  25                  30          


His Pro Gln Phe Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
        35                  40                  45              


Ala Trp Arg His Pro Gln Phe Gly Gly Ser Gly His His His His His 
    50                  55                  60                  


His His His Gln Ala Arg Leu Arg Val Leu Glu Met Tyr Phe Leu Asn 
65                  70                  75                  80  


Asp Thr Leu Ala Ala Glu Asp Ser Pro Ser Phe Ser Leu Leu Gln Ser 
                85                  90                  95      


Ala His Pro Gly Glu His Leu Ala Gln Gly Ala Ser Arg Leu Gln Val 
            100                 105                 110         


Leu Gln Ala Gln Leu Thr Trp Val Arg Val Ser His Glu His Leu Leu 
        115                 120                 125             


Gln Arg Val Asp Asn Phe Thr Gln Asn Pro Gly Met Phe Arg Ile Lys 
    130                 135                 140                 


Gly Glu Gln Gly Ala Pro Gly Leu Gln Gly His Lys Gly Ala Met Gly 
145                 150                 155                 160 


Met Pro Gly Ala Pro Gly Pro Pro Gly Pro Pro Ala Glu Lys Gly Ala 
                165                 170                 175     


Lys Gly Ala Met Gly Arg Asp Gly Ala Thr Gly Pro Ser Gly Pro Gln 
            180                 185                 190         


Gly Pro Pro Gly Val Lys Gly Glu Ala Gly Leu Gln Gly Pro Gln Gly 
        195                 200                 205             


Ala Pro Gly Lys Gln Gly Ala Thr Gly Thr Pro Gly Pro Gln Gly Glu 
    210                 215                 220                 


Lys Gly Ser Lys Gly Asp Gly Gly Leu Ile Gly Pro Lys Gly Glu Thr 
225                 230                 235                 240 


Gly Thr Lys Gly Glu Lys Gly Asp Leu Gly Leu Pro Gly Ser Lys Gly 
                245                 250                 255     


Asp Arg Gly Met Lys Gly Asp Ala Gly Val Met Gly Pro Pro Gly Ala 
            260                 265                 270         


Gln Gly Ser Lys Gly Asp Phe Gly Arg Pro Gly Pro Pro Gly Leu Ala 
        275                 280                 285             


Gly Phe Pro Gly Ala Lys Gly Asp Gln Ser Val Ser Val Arg Ile Val 
    290                 295                 300                 


Gly Ser Ser Asn Arg Gly Arg Ala Glu Val Tyr Tyr Ser Gly Thr Trp 
305                 310                 315                 320 


Gly Thr Ile Cys Asp Asp Glu Trp Gln Asn Ser Asp Ala Ile Val Phe 
                325                 330                 335     


Cys Arg Met Leu Gly Tyr Ser Lys Gly Arg Ala Leu Tyr Lys Val Gly 
            340                 345                 350         


Ala Gly Thr Gly Gln Ile Trp Leu Asp Asn Val Gln Cys Arg Gly Thr 
        355                 360                 365             


Glu Ser Thr Leu Trp Ser Cys Thr Lys Asn Ser Trp Gly His His Asp 
    370                 375                 380                 


Cys Ser His Glu Glu Asp Ala Gly Val Glu Cys Ser Val 
385                 390                 395         


<210>  39
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant protein

<400>  39

Met Gly Ala Ala Ala Arg Thr Leu Arg Leu Ala Leu Gly Leu Leu Leu 
1               5                   10                  15      


Leu Ala Thr Leu Leu Arg Pro Ala Asp Ala Ser Ser Ala Pro His His 
            20                  25                  30          


His His His His His His Ser Gly Gly Leu Asn Asp Ile Phe Glu Ala 
        35                  40                  45              


Gln Lys Ile Glu Trp His Glu Ser Gly Gln Ala Arg Leu Arg Val Leu 
    50                  55                  60                  


Glu Met Tyr Phe Leu Asn Asp Thr Leu Ala Ala Glu Asp Ser Pro Ser 
65                  70                  75                  80  


Phe Ser Leu Leu Gln Ser Ala His Pro Gly Glu His Leu Ala Gln Gly 
                85                  90                  95      


Ala Ser Arg Leu Gln Val Leu Gln Ala Gln Leu Thr Trp Val Arg Val 
            100                 105                 110         


Ser His Glu His Leu Leu Gln Arg Val Asp Asn Phe Thr Gln Asn Pro 
        115                 120                 125             


Gly Met Phe Arg Ile Lys Gly Glu Gln Gly Ala Pro Gly Leu Gln Gly 
    130                 135                 140                 


His Lys Gly Ala Met Gly Met Pro Gly Ala Pro Gly Pro Pro Gly Pro 
145                 150                 155                 160 


Pro Ala Glu Lys Gly Ala Lys Gly Ala Met Gly Arg Asp Gly Ala Thr 
                165                 170                 175     


Gly Pro Ser Gly Pro Gln Gly Pro Pro Gly Val Lys Gly Glu Ala Gly 
            180                 185                 190         


Leu Gln Gly Pro Gln Gly Ala Pro Gly Leu Pro Gly Ser Pro Gly Ser 
        195                 200                 205             


Pro Gly Ala Thr Gly Leu Lys Gly Ser Lys Gly Asp Thr Gly Leu Gln 
    210                 215                 220                 


Gly Gln Gln Gly Arg Lys Gly Glu Ser Gly Val Pro Gly Pro Ala Gly 
225                 230                 235                 240 


Val Lys Gly Glu Gln Gly Ser Pro Gly Leu Ala Gly Pro Lys Gly Ala 
                245                 250                 255     


Pro Gly Gln Ala Gly Gln Lys Gly Asp Gln Gly Val Lys Gly Ser Ser 
            260                 265                 270         


Gly Glu Gln Gly Val Lys Gly Glu Lys Gly Glu Arg Gly Glu Asn Ser 
        275                 280                 285             


Val Ser Val Arg Ile Val Gly Ser Ser Asn Arg Gly Arg Ala Glu Val 
    290                 295                 300                 


Tyr Tyr Ser Gly Thr Trp Gly Thr Ile Cys Asp Asp Glu Trp Gln Asn 
305                 310                 315                 320 


Ser Asp Ala Ile Val Phe Cys Arg Met Leu Gly Tyr Ser Lys Gly Arg 
                325                 330                 335     


Ala Leu Tyr Lys Val Gly Ala Gly Thr Gly Gln Ile Trp Leu Asp Asn 
            340                 345                 350         


Val Gln Cys Arg Gly Thr Glu Ser Thr Leu Trp Ser Cys Thr Lys Asn 
        355                 360                 365             


Ser Trp Gly His His Asp Cys Ser His Glu Glu Asp Ala Gly Val Glu 
    370                 375                 380                 


Cys Ser Val 
385         


<210>  40
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant protein

<400>  40

Met Gly Ala Ala Ala Arg Thr Leu Arg Leu Ala Leu Gly Leu Leu Leu 
1               5                   10                  15      


Leu Ala Thr Leu Leu Arg Pro Ala Asp Ala Ser Ser Ala Ala Trp Arg 
            20                  25                  30          


His Pro Gln Phe Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
        35                  40                  45              


Ala Trp Arg His Pro Gln Phe Gly Gly Ser Gly His His His His His 
    50                  55                  60                  


His His His Gln Ala Arg Leu Arg Val Leu Glu Met Tyr Phe Leu Asn 
65                  70                  75                  80  


Asp Thr Leu Ala Ala Glu Asp Ser Pro Ser Phe Ser Leu Leu Gln Ser 
                85                  90                  95      


Ala His Pro Gly Glu His Leu Ala Gln Gly Ala Ser Arg Leu Gln Val 
            100                 105                 110         


Leu Gln Ala Gln Leu Thr Trp Val Arg Val Ser His Glu His Leu Leu 
        115                 120                 125             


Gln Arg Val Asp Asn Phe Thr Gln Asn Pro Gly Met Phe Arg Ile Lys 
    130                 135                 140                 


Gly Glu Gln Gly Ala Pro Gly Leu Gln Gly His Lys Gly Ala Met Gly 
145                 150                 155                 160 


Met Pro Gly Ala Pro Gly Pro Pro Gly Pro Pro Ala Glu Lys Gly Ala 
                165                 170                 175     


Lys Gly Ala Met Gly Arg Asp Gly Ala Thr Gly Pro Ser Gly Pro Gln 
            180                 185                 190         


Gly Pro Pro Gly Val Lys Gly Glu Ala Gly Leu Gln Gly Pro Gln Gly 
        195                 200                 205             


Ala Pro Gly Leu Pro Gly Ser Pro Gly Ser Pro Gly Ala Thr Gly Leu 
    210                 215                 220                 


Lys Gly Ser Lys Gly Asp Thr Gly Leu Gln Gly Gln Gln Gly Arg Lys 
225                 230                 235                 240 


Gly Glu Ser Gly Val Pro Gly Pro Ala Gly Val Lys Gly Glu Gln Gly 
                245                 250                 255     


Ser Pro Gly Leu Ala Gly Pro Lys Gly Ala Pro Gly Gln Ala Gly Gln 
            260                 265                 270         


Lys Gly Asp Gln Gly Val Lys Gly Ser Ser Gly Glu Gln Gly Val Lys 
        275                 280                 285             


Gly Glu Lys Gly Glu Arg Gly Glu Asn Ser Val Ser Val Arg Ile Val 
    290                 295                 300                 


Gly Ser Ser Asn Arg Gly Arg Ala Glu Val Tyr Tyr Ser Gly Thr Trp 
305                 310                 315                 320 


Gly Thr Ile Cys Asp Asp Glu Trp Gln Asn Ser Asp Ala Ile Val Phe 
                325                 330                 335     


Cys Arg Met Leu Gly Tyr Ser Lys Gly Arg Ala Leu Tyr Lys Val Gly 
            340                 345                 350         


Ala Gly Thr Gly Gln Ile Trp Leu Asp Asn Val Gln Cys Arg Gly Thr 
        355                 360                 365             


Glu Ser Thr Leu Trp Ser Cys Thr Lys Asn Ser Trp Gly His His Asp 
    370                 375                 380                 


Cys Ser His Glu Glu Asp Ala Gly Val Glu Cys Ser Val 
385                 390                 395         


<210>  41
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant protein

<400>  41

Met Gly Ala Ala Ala Arg Thr Leu Arg Leu Ala Leu Gly Leu Leu Leu 
1               5                   10                  15      


Leu Ala Thr Leu Leu Arg Pro Ala Asp Ala Ser Ser Ala Pro His His 
            20                  25                  30          


His His His His His His Ser Gly Gly Leu Asn Asp Ile Phe Glu Ala 
        35                  40                  45              


Gln Lys Ile Glu Trp His Glu Arg Pro Arg Ser Ser Pro Asp Asp Leu 
    50                  55                  60                  


Lys Ala Leu Thr Arg Asn Val Asn Arg Leu Asn Glu Ser Phe Arg Asp 
65                  70                  75                  80  


Leu Gln Leu Arg Leu Leu Gln Ala Pro Leu Gln Ala Asp Leu Thr Glu 
                85                  90                  95      


Gln Val Trp Lys Val Gln Asp Ala Leu Gln Asn Gln Ser Asp Ser Leu 
            100                 105                 110         


Leu Ala Leu Ala Gly Ala Val Gln Arg Leu Glu Gly Ala Leu Trp Gly 
        115                 120                 125             


Leu Gln Ala Gln Ala Val Gln Thr Glu Gln Ala Val Ala Leu Leu Arg 
    130                 135                 140                 


Asp Arg Thr Gly Gln Gln Ser Asp Thr Ala Gln Leu Glu Leu Tyr Gln 
145                 150                 155                 160 


Leu Gln Val Glu Ser Asn Ser Ser Gln Leu Leu Leu Arg Arg His Ala 
                165                 170                 175     


Gly Leu Leu Asp Gly Leu Ala Arg Arg Val Gly Ile Leu Gly Glu Glu 
            180                 185                 190         


Leu Ala Asp Val Gly Gly Val Leu Arg Gly Leu Asn His Ser Leu Ser 
        195                 200                 205             


Tyr Asp Val Ala Leu His Arg Thr Arg Leu Gln Asp Leu Arg Val Leu 
    210                 215                 220                 


Val Ser Asn Ala Ser Glu Asp Thr Arg Arg Leu Arg Leu Ala His Val 
225                 230                 235                 240 


Gly Met Glu Leu Gln Leu Lys Gln Glu Leu Ala Met Leu Asn Ala Val 
                245                 250                 255     


Thr Glu Asp Leu Arg Leu Lys Asp Trp Glu His Ser Ile Ala Leu Arg 
            260                 265                 270         


Asn Ile Ser Leu Ala Lys Gly Pro Pro Gly Pro Lys Gly Asp Gln Gly 
        275                 280                 285             


Asp Glu Gly Lys Glu Gly Arg Pro Gly Ile Pro Gly Leu Pro Gly Leu 
    290                 295                 300                 


Arg Gly Leu Pro Gly Glu Arg Gly Thr Pro Gly Leu Pro Gly Pro Lys 
305                 310                 315                 320 


Gly Asp Asp Gly Lys Leu Gly Ala Thr Gly Pro Met Gly Met Arg Gly 
                325                 330                 335     


Phe Lys Gly Asp Arg Gly Pro Lys Gly Glu Lys Gly Glu Lys Gly Asp 
            340                 345                 350         


Arg Asn Thr Leu Thr Pro Phe Thr Lys Val Arg Leu Val Gly Gly Ser 
        355                 360                 365             


Gly Pro His Glu Gly Arg Val Glu Ile Leu His Ser Gly Gln Trp Gly 
    370                 375                 380                 


Thr Ile Cys Asp Asp Arg Trp Glu Val Arg Val Gly Gln Val Val Cys 
385                 390                 395                 400 


Arg Ser Leu Gly Tyr Pro Gly Val Gln Ala Val His Lys Ala Ala His 
                405                 410                 415     


Phe Gly Gln Gly Thr Gly Pro Ile Trp Leu Asn Glu Val Phe Cys Phe 
            420                 425                 430         


Gly Arg Glu Ser Ser Ile Glu Glu Cys Lys Ile Arg Gln Trp Gly Thr 
        435                 440                 445             


Arg Ala Cys Ser His Ser Glu Asp Ala Gly Val Thr Cys Thr Leu 
    450                 455                 460             


<210>  42
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant protein

<400>  42

Met Gly Ala Ala Ala Arg Thr Leu Arg Leu Ala Leu Gly Leu Leu Leu 
1               5                   10                  15      


Leu Ala Thr Leu Leu Arg Pro Ala Asp Ala Ser Ser Ala Ala Trp Arg 
            20                  25                  30          


His Pro Gln Phe Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
        35                  40                  45              


Ala Trp Arg His Pro Gln Phe Gly Gly Ser Gly His His His His His 
    50                  55                  60                  


His His His Arg Pro Arg Ser Ser Pro Asp Asp Leu Lys Ala Leu Thr 
65                  70                  75                  80  


Arg Asn Val Asn Arg Leu Asn Glu Ser Phe Arg Asp Leu Gln Leu Arg 
                85                  90                  95      


Leu Leu Gln Ala Pro Leu Gln Ala Asp Leu Thr Glu Gln Val Trp Lys 
            100                 105                 110         


Val Gln Asp Ala Leu Gln Asn Gln Ser Asp Ser Leu Leu Ala Leu Ala 
        115                 120                 125             


Gly Ala Val Gln Arg Leu Glu Gly Ala Leu Trp Gly Leu Gln Ala Gln 
    130                 135                 140                 


Ala Val Gln Thr Glu Gln Ala Val Ala Leu Leu Arg Asp Arg Thr Gly 
145                 150                 155                 160 


Gln Gln Ser Asp Thr Ala Gln Leu Glu Leu Tyr Gln Leu Gln Val Glu 
                165                 170                 175     


Ser Asn Ser Ser Gln Leu Leu Leu Arg Arg His Ala Gly Leu Leu Asp 
            180                 185                 190         


Gly Leu Ala Arg Arg Val Gly Ile Leu Gly Glu Glu Leu Ala Asp Val 
        195                 200                 205             


Gly Gly Val Leu Arg Gly Leu Asn His Ser Leu Ser Tyr Asp Val Ala 
    210                 215                 220                 


Leu His Arg Thr Arg Leu Gln Asp Leu Arg Val Leu Val Ser Asn Ala 
225                 230                 235                 240 


Ser Glu Asp Thr Arg Arg Leu Arg Leu Ala His Val Gly Met Glu Leu 
                245                 250                 255     


Gln Leu Lys Gln Glu Leu Ala Met Leu Asn Ala Val Thr Glu Asp Leu 
            260                 265                 270         


Arg Leu Lys Asp Trp Glu His Ser Ile Ala Leu Arg Asn Ile Ser Leu 
        275                 280                 285             


Ala Lys Gly Pro Pro Gly Pro Lys Gly Asp Gln Gly Asp Glu Gly Lys 
    290                 295                 300                 


Glu Gly Arg Pro Gly Ile Pro Gly Leu Pro Gly Leu Arg Gly Leu Pro 
305                 310                 315                 320 


Gly Glu Arg Gly Thr Pro Gly Leu Pro Gly Pro Lys Gly Asp Asp Gly 
                325                 330                 335     


Lys Leu Gly Ala Thr Gly Pro Met Gly Met Arg Gly Phe Lys Gly Asp 
            340                 345                 350         


Arg Gly Pro Lys Gly Glu Lys Gly Glu Lys Gly Asp Arg Asn Thr Leu 
        355                 360                 365             


Thr Pro Phe Thr Lys Val Arg Leu Val Gly Gly Ser Gly Pro His Glu 
    370                 375                 380                 


Gly Arg Val Glu Ile Leu His Ser Gly Gln Trp Gly Thr Ile Cys Asp 
385                 390                 395                 400 


Asp Arg Trp Glu Val Arg Val Gly Gln Val Val Cys Arg Ser Leu Gly 
                405                 410                 415     


Tyr Pro Gly Val Gln Ala Val His Lys Ala Ala His Phe Gly Gln Gly 
            420                 425                 430         


Thr Gly Pro Ile Trp Leu Asn Glu Val Phe Cys Phe Gly Arg Glu Ser 
        435                 440                 445             


Ser Ile Glu Glu Cys Lys Ile Arg Gln Trp Gly Thr Arg Ala Cys Ser 
    450                 455                 460                 


His Ser Glu Asp Ala Gly Val Thr Cys Thr Leu 
465                 470                 475 


<210>  43
<211>  432
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant protein

<400>  43

Met Gly Ala Ala Ala Arg Thr Leu Arg Leu Ala Leu Gly Leu Leu Leu 
1               5                   10                  15      


Leu Ala Thr Leu Leu Arg Pro Ala Asp Ala Ser Ser Ala Pro His His 
            20                  25                  30          


His His His His His His Ser Gly Gly Leu Asn Asp Ile Phe Glu Ala 
        35                  40                  45              


Gln Lys Ile Glu Trp His Glu Ser Gly Lys Trp Glu Thr Lys Asn Cys 
    50                  55                  60                  


Ser Val Ser Ser Thr Asn Ala Asn Asp Ile Thr Gln Ser Leu Thr Gly 
65                  70                  75                  80  


Lys Gly Asn Asp Ser Glu Glu Glu Met Arg Phe Gln Glu Val Phe Met 
                85                  90                  95      


Glu His Met Ser Asn Met Glu Lys Arg Ile Gln His Ile Leu Asp Met 
            100                 105                 110         


Glu Ala Asn Leu Met Asp Thr Glu His Phe Gln Asn Phe Ser Met Thr 
        115                 120                 125             


Thr Asp Gln Arg Phe Asn Asp Ile Leu Leu Gln Leu Ser Thr Leu Phe 
    130                 135                 140                 


Ser Ser Val Gln Gly His Gly Asn Ala Ile Asp Glu Ile Ser Lys Ser 
145                 150                 155                 160 


Leu Ile Ser Leu Asn Thr Thr Leu Leu Asp Leu Gln Leu Asn Ile Glu 
                165                 170                 175     


Asn Leu Asn Gly Lys Ile Gln Glu Asn Thr Phe Lys Gln Gln Glu Glu 
            180                 185                 190         


Ile Ser Lys Leu Glu Glu Arg Val Tyr Asn Val Ser Ala Glu Ile Met 
        195                 200                 205             


Ala Met Lys Glu Glu Gln Val His Leu Glu Gln Glu Ile Lys Gly Glu 
    210                 215                 220                 


Val Lys Val Leu Asn Asn Ile Thr Asn Asp Leu Arg Leu Lys Asp Trp 
225                 230                 235                 240 


Glu His Ser Gln Thr Leu Arg Asn Ile Thr Leu Ile Gln Gly Pro Pro 
                245                 250                 255     


Gly Pro Pro Gly Glu Lys Gly Asp Arg Gly Pro Thr Gly Glu Ser Gly 
            260                 265                 270         


Pro Arg Gly Phe Pro Gly Pro Ile Gly Pro Pro Gly Leu Lys Gly Asp 
        275                 280                 285             


Arg Gly Ala Ile Gly Phe Pro Gly Ser Arg Gly Leu Pro Gly Tyr Ala 
    290                 295                 300                 


Gly Arg Pro Gly Asn Ser Gly Pro Lys Gly Gln Lys Gly Glu Lys Gly 
305                 310                 315                 320 


Ser Gly Asn Thr Leu Thr Pro Phe Thr Lys Val Arg Leu Val Gly Gly 
                325                 330                 335     


Ser Gly Pro His Glu Gly Arg Val Glu Ile Leu His Ser Gly Gln Trp 
            340                 345                 350         


Gly Thr Ile Cys Asp Asp Arg Trp Glu Val Arg Val Gly Gln Val Val 
        355                 360                 365             


Cys Arg Ser Leu Gly Tyr Pro Gly Val Gln Ala Val His Lys Ala Ala 
    370                 375                 380                 


His Phe Gly Gln Gly Thr Gly Pro Ile Trp Leu Asn Glu Val Phe Cys 
385                 390                 395                 400 


Phe Gly Arg Glu Ser Ser Ile Glu Glu Cys Lys Ile Arg Gln Trp Gly 
                405                 410                 415     


Thr Arg Ala Cys Ser His Ser Glu Asp Ala Gly Val Thr Cys Thr Leu 
            420                 425                 430         


<210>  44
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant protein

<400>  44

Met Gly Ala Ala Ala Arg Thr Leu Arg Leu Ala Leu Gly Leu Leu Leu 
1               5                   10                  15      


Leu Ala Thr Leu Leu Arg Pro Ala Asp Ala Ser Ser Ala Ala Trp Arg 
            20                  25                  30          


His Pro Gln Phe Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
        35                  40                  45              


Ala Trp Arg His Pro Gln Phe Gly Gly Ser Gly His His His His His 
    50                  55                  60                  


His His His Lys Trp Glu Thr Lys Asn Cys Ser Val Ser Ser Thr Asn 
65                  70                  75                  80  


Ala Asn Asp Ile Thr Gln Ser Leu Thr Gly Lys Gly Asn Asp Ser Glu 
                85                  90                  95      


Glu Glu Met Arg Phe Gln Glu Val Phe Met Glu His Met Ser Asn Met 
            100                 105                 110         


Glu Lys Arg Ile Gln His Ile Leu Asp Met Glu Ala Asn Leu Met Asp 
        115                 120                 125             


Thr Glu His Phe Gln Asn Phe Ser Met Thr Thr Asp Gln Arg Phe Asn 
    130                 135                 140                 


Asp Ile Leu Leu Gln Leu Ser Thr Leu Phe Ser Ser Val Gln Gly His 
145                 150                 155                 160 


Gly Asn Ala Ile Asp Glu Ile Ser Lys Ser Leu Ile Ser Leu Asn Thr 
                165                 170                 175     


Thr Leu Leu Asp Leu Gln Leu Asn Ile Glu Asn Leu Asn Gly Lys Ile 
            180                 185                 190         


Gln Glu Asn Thr Phe Lys Gln Gln Glu Glu Ile Ser Lys Leu Glu Glu 
        195                 200                 205             


Arg Val Tyr Asn Val Ser Ala Glu Ile Met Ala Met Lys Glu Glu Gln 
    210                 215                 220                 


Val His Leu Glu Gln Glu Ile Lys Gly Glu Val Lys Val Leu Asn Asn 
225                 230                 235                 240 


Ile Thr Asn Asp Leu Arg Leu Lys Asp Trp Glu His Ser Gln Thr Leu 
                245                 250                 255     


Arg Asn Ile Thr Leu Ile Gln Gly Pro Pro Gly Pro Pro Gly Glu Lys 
            260                 265                 270         


Gly Asp Arg Gly Pro Thr Gly Glu Ser Gly Pro Arg Gly Phe Pro Gly 
        275                 280                 285             


Pro Ile Gly Pro Pro Gly Leu Lys Gly Asp Arg Gly Ala Ile Gly Phe 
    290                 295                 300                 


Pro Gly Ser Arg Gly Leu Pro Gly Tyr Ala Gly Arg Pro Gly Asn Ser 
305                 310                 315                 320 


Gly Pro Lys Gly Gln Lys Gly Glu Lys Gly Ser Gly Asn Thr Leu Thr 
                325                 330                 335     


Pro Phe Thr Lys Val Arg Leu Val Gly Gly Ser Gly Pro His Glu Gly 
            340                 345                 350         


Arg Val Glu Ile Leu His Ser Gly Gln Trp Gly Thr Ile Cys Asp Asp 
        355                 360                 365             


Arg Trp Glu Val Arg Val Gly Gln Val Val Cys Arg Ser Leu Gly Tyr 
    370                 375                 380                 


Pro Gly Val Gln Ala Val His Lys Ala Ala His Phe Gly Gln Gly Thr 
385                 390                 395                 400 


Gly Pro Ile Trp Leu Asn Glu Val Phe Cys Phe Gly Arg Glu Ser Ser 
                405                 410                 415     


Ile Glu Glu Cys Lys Ile Arg Gln Trp Gly Thr Arg Ala Cys Ser His 
            420                 425                 430         


Ser Glu Asp Ala Gly Val Thr Cys Thr Leu 
        435                 440         


<210>  45
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker or affinity tag

<400>  45

Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
1               5                   10                  15  


<210>  46
<211>  606
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Lys Val Arg Ser Ala Gly Gly Asp Gly Asp Ala Leu Cys Val Thr 
1               5                   10                  15      


Glu Glu Asp Leu Ala Gly Asp Asp Glu Asp Met Pro Thr Phe Pro Cys 
            20                  25                  30          


Thr Gln Lys Gly Arg Pro Gly Pro Arg Cys Ser Arg Cys Gln Lys Asn 
        35                  40                  45              


Leu Ser Leu His Thr Ser Val Arg Ile Leu Tyr Leu Phe Leu Ala Leu 
    50                  55                  60                  


Leu Leu Val Ala Val Ala Val Leu Ala Ser Leu Val Phe Arg Lys Val 
65                  70                  75                  80  


Asp Ser Leu Ser Glu Asp Ile Ser Leu Thr Gln Ser Ile Tyr Asp Lys 
                85                  90                  95      


Lys Leu Val Leu Met Gln Lys Asn Leu Gln Gly Leu Asp Pro Lys Ala 
            100                 105                 110         


Leu Asn Asn Cys Ser Phe Cys His Glu Ala Gly Gln Leu Gly Pro Glu 
        115                 120                 125             


Ile Arg Lys Leu Gln Glu Glu Leu Glu Gly Ile Gln Lys Leu Leu Leu 
    130                 135                 140                 


Ala Gln Glu Val Gln Leu Asp Gln Thr Leu Gln Ala Gln Glu Val Leu 
145                 150                 155                 160 


Ser Thr Thr Ser Arg Gln Ile Ser Gln Glu Met Gly Ser Cys Ser Phe 
                165                 170                 175     


Ser Ile His Gln Val Asn Gln Ser Leu Gly Leu Phe Leu Ala Gln Val 
            180                 185                 190         


Arg Gly Trp Gln Ala Thr Thr Ala Gly Leu Asp Leu Ser Leu Lys Asp 
        195                 200                 205             


Leu Thr Gln Glu Cys Tyr Asp Val Lys Ala Ala Val His Gln Ile Asn 
    210                 215                 220                 


Phe Thr Val Gly Gln Thr Ser Glu Trp Ile His Gly Ile Gln Arg Lys 
225                 230                 235                 240 


Thr Asp Glu Glu Thr Leu Thr Leu Gln Lys Ile Val Thr Asp Trp Gln 
                245                 250                 255     


Asn Tyr Thr Arg Leu Phe Ser Gly Leu Arg Thr Thr Ser Thr Lys Thr 
            260                 265                 270         


Gly Glu Ala Val Lys Asn Ile Gln Ala Thr Leu Gly Ala Ser Ser Gln 
        275                 280                 285             


Arg Ile Ser Gln Asn Ser Glu Ser Met His Asp Leu Val Leu Gln Val 
    290                 295                 300                 


Met Gly Leu Gln Leu Gln Leu Asp Asn Ile Ser Ser Phe Leu Asp Asp 
305                 310                 315                 320 


His Glu Glu Asn Met His Asp Leu Gln Tyr His Thr His Tyr Ala Gln 
                325                 330                 335     


Asn Arg Thr Val Glu Arg Phe Glu Ser Leu Glu Gly Arg Met Ala Ser 
            340                 345                 350         


His Glu Ile Glu Ile Gly Thr Ile Phe Thr Asn Ile Asn Ala Thr Asp 
        355                 360                 365             


Asn His Val His Ser Met Leu Lys Tyr Leu Asp Asp Val Arg Leu Ser 
    370                 375                 380                 


Cys Thr Leu Gly Phe His Thr His Ala Glu Glu Leu Tyr Tyr Leu Asn 
385                 390                 395                 400 


Lys Ser Val Ser Ile Met Leu Gly Thr Thr Asp Leu Leu Arg Glu Arg 
                405                 410                 415     


Phe Ser Leu Leu Ser Ala Arg Leu Asp Leu Asn Val Arg Asn Leu Ser 
            420                 425                 430         


Met Ile Val Glu Glu Met Lys Ala Val Asp Thr Gln His Gly Glu Ile 
        435                 440                 445             


Leu Arg Asn Val Thr Ile Leu Arg Gly Ala Pro Gly Pro Pro Gly Pro 
    450                 455                 460                 


Arg Gly Phe Lys Gly Asp Met Gly Val Lys Gly Pro Val Gly Gly Arg 
465                 470                 475                 480 


Gly Pro Lys Gly Asp Pro Gly Ser Leu Gly Pro Leu Gly Pro Gln Gly 
                485                 490                 495     


Pro Gln Gly Gln Pro Gly Glu Ala Gly Pro Val Gly Glu Arg Gly Pro 
            500                 505                 510         


Val Gly Pro Arg Gly Phe Pro Gly Leu Lys Gly Ser Lys Gly Ser Phe 
        515                 520                 525             


Gly Thr Gly Gly Pro Arg Gly Gln Pro Gly Pro Lys Gly Asp Ile Gly 
    530                 535                 540                 


Pro Pro Gly Pro Glu Gly Pro Pro Gly Ser Pro Gly Pro Ser Gly Pro 
545                 550                 555                 560 


Gln Gly Lys Pro Gly Ile Ala Gly Lys Thr Gly Ser Pro Gly Gln Arg 
                565                 570                 575     


Gly Ala Met Gly Pro Lys Gly Glu Pro Gly Ile Gln Gly Pro Pro Gly 
            580                 585                 590         


Leu Pro Gly Pro Pro Gly Pro Pro Gly Ser Gln Ser Phe Tyr 
        595                 600                 605     


<210>  47
<211>  472
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Gly Cys Asp Arg Asn Cys Gly Leu Ile Ala Gly Ala Val Ile Gly 
1               5                   10                  15      


Ala Val Leu Ala Val Phe Gly Gly Ile Leu Met Pro Val Gly Asp Leu 
            20                  25                  30          


Leu Ile Gln Lys Thr Ile Lys Lys Gln Val Val Leu Glu Glu Gly Thr 
        35                  40                  45              


Ile Ala Phe Lys Asn Trp Val Lys Thr Gly Thr Glu Val Tyr Arg Gln 
    50                  55                  60                  


Phe Trp Ile Phe Asp Val Gln Asn Pro Gln Glu Val Met Met Asn Ser 
65                  70                  75                  80  


Ser Asn Ile Gln Val Lys Gln Arg Gly Pro Tyr Thr Tyr Arg Val Arg 
                85                  90                  95      


Phe Leu Ala Lys Glu Asn Val Thr Gln Asp Ala Glu Asp Asn Thr Val 
            100                 105                 110         


Ser Phe Leu Gln Pro Asn Gly Ala Ile Phe Glu Pro Ser Leu Ser Val 
        115                 120                 125             


Gly Thr Glu Ala Asp Asn Phe Thr Val Leu Asn Leu Ala Val Ala Ala 
    130                 135                 140                 


Ala Ser His Ile Tyr Gln Asn Gln Phe Val Gln Met Ile Leu Asn Ser 
145                 150                 155                 160 


Leu Ile Asn Lys Ser Lys Ser Ser Met Phe Gln Val Arg Thr Leu Arg 
                165                 170                 175     


Glu Leu Leu Trp Gly Tyr Arg Asp Pro Phe Leu Ser Leu Val Pro Tyr 
            180                 185                 190         


Pro Val Thr Thr Thr Val Gly Leu Phe Tyr Pro Tyr Asn Asn Thr Ala 
        195                 200                 205             


Asp Gly Val Tyr Lys Val Phe Asn Gly Lys Asp Asn Ile Ser Lys Val 
    210                 215                 220                 


Ala Ile Ile Asp Thr Tyr Lys Gly Lys Arg Asn Leu Ser Tyr Trp Glu 
225                 230                 235                 240 


Ser His Cys Asp Met Ile Asn Gly Thr Asp Ala Ala Ser Phe Pro Pro 
                245                 250                 255     


Phe Val Glu Lys Ser Gln Val Leu Gln Phe Phe Ser Ser Asp Ile Cys 
            260                 265                 270         


Arg Ser Ile Tyr Ala Val Phe Glu Ser Asp Val Asn Leu Lys Gly Ile 
        275                 280                 285             


Pro Val Tyr Arg Phe Val Leu Pro Ser Lys Ala Phe Ala Ser Pro Val 
    290                 295                 300                 


Glu Asn Pro Asp Asn Tyr Cys Phe Cys Thr Glu Lys Ile Ile Ser Lys 
305                 310                 315                 320 


Asn Cys Thr Ser Tyr Gly Val Leu Asp Ile Ser Lys Cys Lys Glu Gly 
                325                 330                 335     


Arg Pro Val Tyr Ile Ser Leu Pro His Phe Leu Tyr Ala Ser Pro Asp 
            340                 345                 350         


Val Ser Glu Pro Ile Asp Gly Leu Asn Pro Asn Glu Glu Glu His Arg 
        355                 360                 365             


Thr Tyr Leu Asp Ile Glu Pro Ile Thr Gly Phe Thr Leu Gln Phe Ala 
    370                 375                 380                 


Lys Arg Leu Gln Val Asn Leu Leu Val Lys Pro Ser Glu Lys Ile Gln 
385                 390                 395                 400 


Val Leu Lys Asn Leu Lys Arg Asn Tyr Ile Val Pro Ile Leu Trp Leu 
                405                 410                 415     


Asn Glu Thr Gly Thr Ile Gly Asp Glu Lys Ala Asn Met Phe Arg Ser 
            420                 425                 430         


Gln Val Thr Gly Lys Ile Asn Leu Leu Gly Leu Ile Glu Met Ile Leu 
        435                 440                 445             


Leu Ser Val Gly Val Val Met Phe Val Ala Phe Met Ile Ser Tyr Cys 
    450                 455                 460                 


Ala Cys Arg Ser Lys Thr Ile Lys 
465                 470         


<210>  48
<211>  1156
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Ser Lys Leu Arg Met Val Leu Leu Glu Asp Ser Gly Ser Ala Asp 
1               5                   10                  15      


Phe Arg Arg His Phe Val Asn Leu Ser Pro Phe Thr Ile Thr Val Val 
            20                  25                  30          


Leu Leu Leu Ser Ala Cys Phe Val Thr Ser Ser Leu Gly Gly Thr Asp 
        35                  40                  45              


Lys Glu Leu Arg Leu Val Asp Gly Glu Asn Lys Cys Ser Gly Arg Val 
    50                  55                  60                  


Glu Val Lys Val Gln Glu Glu Trp Gly Thr Val Cys Asn Asn Gly Trp 
65                  70                  75                  80  


Ser Met Glu Ala Val Ser Val Ile Cys Asn Gln Leu Gly Cys Pro Thr 
                85                  90                  95      


Ala Ile Lys Ala Pro Gly Trp Ala Asn Ser Ser Ala Gly Ser Gly Arg 
            100                 105                 110         


Ile Trp Met Asp His Val Ser Cys Arg Gly Asn Glu Ser Ala Leu Trp 
        115                 120                 125             


Asp Cys Lys His Asp Gly Trp Gly Lys His Ser Asn Cys Thr His Gln 
    130                 135                 140                 


Gln Asp Ala Gly Val Thr Cys Ser Asp Gly Ser Asn Leu Glu Met Arg 
145                 150                 155                 160 


Leu Thr Arg Gly Gly Asn Met Cys Ser Gly Arg Ile Glu Ile Lys Phe 
                165                 170                 175     


Gln Gly Arg Trp Gly Thr Val Cys Asp Asp Asn Phe Asn Ile Asp His 
            180                 185                 190         


Ala Ser Val Ile Cys Arg Gln Leu Glu Cys Gly Ser Ala Val Ser Phe 
        195                 200                 205             


Ser Gly Ser Ser Asn Phe Gly Glu Gly Ser Gly Pro Ile Trp Phe Asp 
    210                 215                 220                 


Asp Leu Ile Cys Asn Gly Asn Glu Ser Ala Leu Trp Asn Cys Lys His 
225                 230                 235                 240 


Gln Gly Trp Gly Lys His Asn Cys Asp His Ala Glu Asp Ala Gly Val 
                245                 250                 255     


Ile Cys Ser Lys Gly Ala Asp Leu Ser Leu Arg Leu Val Asp Gly Val 
            260                 265                 270         


Thr Glu Cys Ser Gly Arg Leu Glu Val Arg Phe Gln Gly Glu Trp Gly 
        275                 280                 285             


Thr Ile Cys Asp Asp Gly Trp Asp Ser Tyr Asp Ala Ala Val Ala Cys 
    290                 295                 300                 


Lys Gln Leu Gly Cys Pro Thr Ala Val Thr Ala Ile Gly Arg Val Asn 
305                 310                 315                 320 


Ala Ser Lys Gly Phe Gly His Ile Trp Leu Asp Ser Val Ser Cys Gln 
                325                 330                 335     


Gly His Glu Pro Ala Ile Trp Gln Cys Lys His His Glu Trp Gly Lys 
            340                 345                 350         


His Tyr Cys Asn His Asn Glu Asp Ala Gly Val Thr Cys Ser Asp Gly 
        355                 360                 365             


Ser Asp Leu Glu Leu Arg Leu Arg Gly Gly Gly Ser Arg Cys Ala Gly 
    370                 375                 380                 


Thr Val Glu Val Glu Ile Gln Arg Leu Leu Gly Lys Val Cys Asp Arg 
385                 390                 395                 400 


Gly Trp Gly Leu Lys Glu Ala Asp Val Val Cys Arg Gln Leu Gly Cys 
                405                 410                 415     


Gly Ser Ala Leu Lys Thr Ser Tyr Gln Val Tyr Ser Lys Ile Gln Ala 
            420                 425                 430         


Thr Asn Thr Trp Leu Phe Leu Ser Ser Cys Asn Gly Asn Glu Thr Ser 
        435                 440                 445             


Leu Trp Asp Cys Lys Asn Trp Gln Trp Gly Gly Leu Thr Cys Asp His 
    450                 455                 460                 


Tyr Glu Glu Ala Lys Ile Thr Cys Ser Ala His Arg Glu Pro Arg Leu 
465                 470                 475                 480 


Val Gly Gly Asp Ile Pro Cys Ser Gly Arg Val Glu Val Lys His Gly 
                485                 490                 495     


Asp Thr Trp Gly Ser Ile Cys Asp Ser Asp Phe Ser Leu Glu Ala Ala 
            500                 505                 510         


Ser Val Leu Cys Arg Glu Leu Gln Cys Gly Thr Val Val Ser Ile Leu 
        515                 520                 525             


Gly Gly Ala His Phe Gly Glu Gly Asn Gly Gln Ile Trp Ala Glu Glu 
    530                 535                 540                 


Phe Gln Cys Glu Gly His Glu Ser His Leu Ser Leu Cys Pro Val Ala 
545                 550                 555                 560 


Pro Arg Pro Glu Gly Thr Cys Ser His Ser Arg Asp Val Gly Val Val 
                565                 570                 575     


Cys Ser Arg Tyr Thr Glu Ile Arg Leu Val Asn Gly Lys Thr Pro Cys 
            580                 585                 590         


Glu Gly Arg Val Glu Leu Lys Thr Leu Gly Ala Trp Gly Ser Leu Cys 
        595                 600                 605             


Asn Ser His Trp Asp Ile Glu Asp Ala His Val Leu Cys Gln Gln Leu 
    610                 615                 620                 


Lys Cys Gly Val Ala Leu Ser Thr Pro Gly Gly Ala Arg Phe Gly Lys 
625                 630                 635                 640 


Gly Asn Gly Gln Ile Trp Arg His Met Phe His Cys Thr Gly Thr Glu 
                645                 650                 655     


Gln His Met Gly Asp Cys Pro Val Thr Ala Leu Gly Ala Ser Leu Cys 
            660                 665                 670         


Pro Ser Glu Gln Val Ala Ser Val Ile Cys Ser Gly Asn Gln Ser Gln 
        675                 680                 685             


Thr Leu Ser Ser Cys Asn Ser Ser Ser Leu Gly Pro Thr Arg Pro Thr 
    690                 695                 700                 


Ile Pro Glu Glu Ser Ala Val Ala Cys Ile Glu Ser Gly Gln Leu Arg 
705                 710                 715                 720 


Leu Val Asn Gly Gly Gly Arg Cys Ala Gly Arg Val Glu Ile Tyr His 
                725                 730                 735     


Glu Gly Ser Trp Gly Thr Ile Cys Asp Asp Ser Trp Asp Leu Ser Asp 
            740                 745                 750         


Ala His Val Val Cys Arg Gln Leu Gly Cys Gly Glu Ala Ile Asn Ala 
        755                 760                 765             


Thr Gly Ser Ala His Phe Gly Glu Gly Thr Gly Pro Ile Trp Leu Asp 
    770                 775                 780                 


Glu Met Lys Cys Asn Gly Lys Glu Ser Arg Ile Trp Gln Cys His Ser 
785                 790                 795                 800 


His Gly Trp Gly Gln Gln Asn Cys Arg His Lys Glu Asp Ala Gly Val 
                805                 810                 815     


Ile Cys Ser Glu Phe Met Ser Leu Arg Leu Thr Ser Glu Ala Ser Arg 
            820                 825                 830         


Glu Ala Cys Ala Gly Arg Leu Glu Val Phe Tyr Asn Gly Ala Trp Gly 
        835                 840                 845             


Thr Val Gly Lys Ser Ser Met Ser Glu Thr Thr Val Gly Val Val Cys 
    850                 855                 860                 


Arg Gln Leu Gly Cys Ala Asp Lys Gly Lys Ile Asn Pro Ala Ser Leu 
865                 870                 875                 880 


Asp Lys Ala Met Ser Ile Pro Met Trp Val Asp Asn Val Gln Cys Pro 
                885                 890                 895     


Lys Gly Pro Asp Thr Leu Trp Gln Cys Pro Ser Ser Pro Trp Glu Lys 
            900                 905                 910         


Arg Leu Ala Ser Pro Ser Glu Glu Thr Trp Ile Thr Cys Asp Asn Lys 
        915                 920                 925             


Ile Arg Leu Gln Glu Gly Pro Thr Ser Cys Ser Gly Arg Val Glu Ile 
    930                 935                 940                 


Trp His Gly Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Leu 
945                 950                 955                 960 


Asp Asp Ala Gln Val Val Cys Gln Gln Leu Gly Cys Gly Pro Ala Leu 
                965                 970                 975     


Lys Ala Phe Lys Glu Ala Glu Phe Gly Gln Gly Thr Gly Pro Ile Trp 
            980                 985                 990         


Leu Asn Glu Val Lys Cys Lys Gly  Asn Glu Ser Ser Leu  Trp Asp Cys 
        995                 1000                 1005             


Pro Ala  Arg Arg Trp Gly His  Ser Glu Cys Gly His  Lys Glu Asp 
    1010                 1015                 1020             


Ala Ala  Val Asn Cys Thr Asp  Ile Ser Val Gln Lys  Thr Pro Gln 
    1025                 1030                 1035             


Lys Ala  Thr Thr Gly Arg Ser  Ser Arg Gln Ser Ser  Phe Ile Ala 
    1040                 1045                 1050             


Val Gly  Ile Leu Gly Val Val  Leu Leu Ala Ile Phe  Val Ala Leu 
    1055                 1060                 1065             


Phe Phe  Leu Thr Lys Lys Arg  Arg Gln Arg Gln Arg  Leu Ala Val 
    1070                 1075                 1080             


Ser Ser  Arg Gly Glu Asn Leu  Val His Gln Ile Gln  Tyr Arg Glu 
    1085                 1090                 1095             


Met Asn  Ser Cys Leu Asn Ala  Asp Asp Leu Asp Leu  Met Asn Ser 
    1100                 1105                 1110             


Ser Glu  Asn Ser His Glu Ser  Ala Asp Phe Ser Ala  Ala Glu Leu 
    1115                 1120                 1125             


Ile Ser  Val Ser Lys Phe Leu  Pro Ile Ser Gly Met  Glu Lys Glu 
    1130                 1135                 1140             


Ala Ile  Leu Ser His Thr Glu  Lys Glu Asn Gly Asn  Leu 
    1145                 1150                 1155     


<210>  49
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Arg Leu Ala Val Leu Phe Ser Gly Ala Leu Leu Gly Leu Leu Ala 
1               5                   10                  15      


Ala Gln Gly Thr Gly Asn Asp Cys Pro His Lys Lys Ser Ala Thr Leu 
            20                  25                  30          


Leu Pro Ser Phe Thr Val Thr Pro Thr Val Thr Glu Ser Thr Gly Thr 
        35                  40                  45              


Thr Ser His Arg Thr Thr Lys Ser His Lys Thr Thr Thr His Arg Thr 
    50                  55                  60                  


Thr Thr Thr Gly Thr Thr Ser His Gly Pro Thr Thr Ala Thr His Asn 
65                  70                  75                  80  


Pro Thr Thr Thr Ser His Gly Asn Val Thr Val His Pro Thr Ser Asn 
                85                  90                  95      


Ser Thr Ala Thr Ser Gln Gly Pro Ser Thr Ala Thr His Ser Pro Ala 
            100                 105                 110         


Thr Thr Ser His Gly Asn Ala Thr Val His Pro Thr Ser Asn Ser Thr 
        115                 120                 125             


Ala Thr Ser Pro Gly Phe Thr Ser Ser Ala His Pro Glu Pro Pro Pro 
    130                 135                 140                 


Pro Ser Pro Ser Pro Ser Pro Thr Ser Lys Glu Thr Ile Gly Asp Tyr 
145                 150                 155                 160 


Thr Trp Thr Asn Gly Ser Gln Pro Cys Val His Leu Gln Ala Gln Ile 
                165                 170                 175     


Gln Ile Arg Val Met Tyr Thr Thr Gln Gly Gly Gly Glu Ala Trp Gly 
            180                 185                 190         


Ile Ser Val Leu Asn Pro Asn Lys Thr Lys Val Gln Gly Ser Cys Glu 
        195                 200                 205             


Gly Ala His Pro His Leu Leu Leu Ser Phe Pro Tyr Gly His Leu Ser 
    210                 215                 220                 


Phe Gly Phe Met Gln Asp Leu Gln Gln Lys Val Val Tyr Leu Ser Tyr 
225                 230                 235                 240 


Met Ala Val Glu Tyr Asn Val Ser Phe Pro His Ala Ala Gln Trp Thr 
                245                 250                 255     


Phe Ser Ala Gln Asn Ala Ser Leu Arg Asp Leu Gln Ala Pro Leu Gly 
            260                 265                 270         


Gln Ser Phe Ser Cys Ser Asn Ser Ser Ile Ile Leu Ser Pro Ala Val 
        275                 280                 285             


His Leu Asp Leu Leu Ser Leu Arg Leu Gln Ala Ala Gln Leu Pro His 
    290                 295                 300                 


Thr Gly Val Phe Gly Gln Ser Phe Ser Cys Pro Ser Asp Arg Ser Ile 
305                 310                 315                 320 


Leu Leu Pro Leu Ile Ile Gly Leu Ile Leu Leu Gly Leu Leu Ala Leu 
                325                 330                 335     


Val Leu Ile Ala Phe Cys Ile Ile Arg Arg Arg Pro Ser Ala Tyr Gln 
            340                 345                 350         


Ala Leu 
        


<210>  50
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Thr Phe Asp Asp Leu Lys Ile Gln Thr Val Lys Asp Gln Pro Asp 
1               5                   10                  15      


Glu Lys Ser Asn Gly Lys Lys Ala Lys Gly Leu Gln Phe Leu Tyr Ser 
            20                  25                  30          


Pro Trp Trp Cys Leu Ala Ala Ala Thr Leu Gly Val Leu Cys Leu Gly 
        35                  40                  45              


Leu Val Val Thr Ile Met Val Leu Gly Met Gln Leu Ser Gln Val Ser 
    50                  55                  60                  


Asp Leu Leu Thr Gln Glu Gln Ala Asn Leu Thr His Gln Lys Lys Lys 
65                  70                  75                  80  


Leu Glu Gly Gln Ile Ser Ala Arg Gln Gln Ala Glu Glu Ala Ser Gln 
                85                  90                  95      


Glu Ser Glu Asn Glu Leu Lys Glu Met Ile Glu Thr Leu Ala Arg Lys 
            100                 105                 110         


Leu Asn Glu Lys Ser Lys Glu Gln Met Glu Leu His His Gln Asn Leu 
        115                 120                 125             


Asn Leu Gln Glu Thr Leu Lys Arg Val Ala Asn Cys Ser Ala Pro Cys 
    130                 135                 140                 


Pro Gln Asp Trp Ile Trp His Gly Glu Asn Cys Tyr Leu Phe Ser Ser 
145                 150                 155                 160 


Gly Ser Phe Asn Trp Glu Lys Ser Gln Glu Lys Cys Leu Ser Leu Asp 
                165                 170                 175     


Ala Lys Leu Leu Lys Ile Asn Ser Thr Ala Asp Leu Asp Phe Ile Gln 
            180                 185                 190         


Gln Ala Ile Ser Tyr Ser Ser Phe Pro Phe Trp Met Gly Leu Ser Arg 
        195                 200                 205             


Arg Asn Pro Ser Tyr Pro Trp Leu Trp Glu Asp Gly Ser Pro Leu Met 
    210                 215                 220                 


Pro His Leu Phe Arg Val Arg Gly Ala Val Ser Gln Thr Tyr Pro Ser 
225                 230                 235                 240 


Gly Thr Cys Ala Tyr Ile Gln Arg Gly Ala Val Tyr Ala Glu Asn Cys 
                245                 250                 255     


Ile Leu Ala Ala Phe Ser Ile Cys Gln Lys Lys Ala Asn Leu Arg Ala 
            260                 265                 270         


Gln 
    


<210>  51
<211>  830
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Gly Leu Gly Leu Leu Leu Pro Leu Leu Leu Leu Trp Thr Arg Gly 
1               5                   10                  15      


Thr Gln Gly Ser Glu Leu Asp Pro Lys Gly Gln His Val Cys Val Ala 
            20                  25                  30          


Ser Ser Pro Ser Ala Glu Leu Gln Cys Cys Ala Gly Trp Arg Gln Lys 
        35                  40                  45              


Asp Gln Glu Cys Thr Ile Pro Ile Cys Glu Gly Pro Asp Ala Cys Gln 
    50                  55                  60                  


Lys Asp Glu Val Cys Val Lys Pro Gly Leu Cys Arg Cys Lys Pro Gly 
65                  70                  75                  80  


Phe Phe Gly Ala His Cys Ser Ser Arg Cys Pro Gly Gln Tyr Trp Gly 
                85                  90                  95      


Pro Asp Cys Arg Glu Ser Cys Pro Cys His Pro His Gly Gln Cys Glu 
            100                 105                 110         


Pro Ala Thr Gly Ala Cys Gln Cys Gln Ala Asp Arg Trp Gly Ala Arg 
        115                 120                 125             


Cys Glu Phe Pro Cys Ala Cys Gly Pro His Gly Arg Cys Asp Pro Ala 
    130                 135                 140                 


Thr Gly Val Cys His Cys Glu Pro Gly Trp Trp Ser Ser Thr Cys Arg 
145                 150                 155                 160 


Arg Pro Cys Gln Cys Asn Thr Ala Ala Ala Arg Cys Glu Gln Ala Thr 
                165                 170                 175     


Gly Ala Cys Val Cys Lys Pro Gly Trp Trp Gly Arg Arg Cys Ser Phe 
            180                 185                 190         


Arg Cys Asn Cys His Gly Ser Pro Cys Glu Gln Asp Ser Gly Arg Cys 
        195                 200                 205             


Ala Cys Arg Pro Gly Trp Trp Gly Pro Glu Cys Gln Gln Gln Cys Glu 
    210                 215                 220                 


Cys Val Arg Gly Arg Cys Ser Ala Ala Ser Gly Glu Cys Thr Cys Pro 
225                 230                 235                 240 


Pro Gly Phe Arg Gly Ala Arg Cys Glu Leu Pro Cys Pro Ala Gly Ser 
                245                 250                 255     


His Gly Val Gln Cys Ala His Ser Cys Gly Arg Cys Lys His Asn Glu 
            260                 265                 270         


Pro Cys Ser Pro Asp Thr Gly Ser Cys Glu Ser Cys Glu Pro Gly Trp 
        275                 280                 285             


Asn Gly Thr Gln Cys Gln Gln Pro Cys Leu Pro Gly Thr Phe Gly Glu 
    290                 295                 300                 


Ser Cys Glu Gln Gln Cys Pro His Cys Arg His Gly Glu Ala Cys Glu 
305                 310                 315                 320 


Pro Asp Thr Gly His Cys Gln Arg Cys Asp Pro Gly Trp Leu Gly Pro 
                325                 330                 335     


Arg Cys Glu Asp Pro Cys Pro Thr Gly Thr Phe Gly Glu Asp Cys Gly 
            340                 345                 350         


Ser Thr Cys Pro Thr Cys Val Gln Gly Ser Cys Asp Thr Val Thr Gly 
        355                 360                 365             


Asp Cys Val Cys Ser Ala Gly Tyr Trp Gly Pro Ser Cys Asn Ala Ser 
    370                 375                 380                 


Cys Pro Ala Gly Phe His Gly Asn Asn Cys Ser Val Pro Cys Glu Cys 
385                 390                 395                 400 


Pro Glu Gly Leu Cys His Pro Val Ser Gly Ser Cys Gln Pro Gly Ser 
                405                 410                 415     


Gly Ser Arg Asp Thr Ala Leu Ile Ala Gly Ser Leu Val Pro Leu Leu 
            420                 425                 430         


Leu Leu Phe Leu Gly Leu Ala Cys Cys Ala Cys Cys Cys Trp Ala Pro 
        435                 440                 445             


Arg Ser Asp Leu Lys Asp Arg Pro Ala Arg Asp Gly Ala Thr Val Ser 
    450                 455                 460                 


Arg Met Lys Leu Gln Val Trp Gly Thr Leu Thr Ser Leu Gly Ser Thr 
465                 470                 475                 480 


Leu Pro Cys Arg Ser Leu Ser Ser His Lys Leu Pro Trp Val Thr Val 
                485                 490                 495     


Ser His His Asp Pro Glu Val Pro Phe Asn His Ser Phe Ile Glu Pro 
            500                 505                 510         


Pro Ser Ala Gly Trp Ala Thr Asp Asp Ser Phe Ser Ser Asp Pro Glu 
        515                 520                 525             


Ser Gly Glu Ala Asp Glu Val Pro Ala Tyr Cys Val Pro Pro Gln Glu 
    530                 535                 540                 


Gly Met Val Pro Val Ala Gln Ala Gly Ser Ser Glu Ala Ser Leu Ala 
545                 550                 555                 560 


Ala Gly Ala Phe Pro Pro Pro Glu Asp Ala Ser Thr Pro Phe Ala Ile 
                565                 570                 575     


Pro Arg Thr Ser Ser Leu Ala Arg Ala Lys Arg Pro Ser Val Ser Phe 
            580                 585                 590         


Ala Glu Gly Thr Lys Phe Ala Pro Gln Ser Arg Arg Ser Ser Gly Glu 
        595                 600                 605             


Leu Ser Ser Pro Leu Arg Lys Pro Lys Arg Leu Ser Arg Gly Ala Gln 
    610                 615                 620                 


Ser Gly Pro Glu Gly Arg Glu Ala Glu Glu Ser Thr Gly Pro Glu Glu 
625                 630                 635                 640 


Ala Glu Ala Pro Glu Ser Phe Pro Ala Ala Ala Ser Pro Gly Asp Ser 
                645                 650                 655     


Ala Thr Gly His Arg Arg Pro Pro Leu Gly Gly Arg Thr Val Ala Glu 
            660                 665                 670         


His Val Glu Ala Ile Glu Gly Ser Val Gln Glu Ser Ser Gly Pro Val 
        675                 680                 685             


Thr Thr Ile Tyr Met Leu Ala Gly Lys Pro Arg Gly Ser Glu Gly Pro 
    690                 695                 700                 


Val Arg Ser Val Phe Arg His Phe Gly Ser Phe Gln Lys Gly Gln Ala 
705                 710                 715                 720 


Glu Ala Lys Val Lys Arg Ala Ile Pro Lys Pro Pro Arg Gln Ala Leu 
                725                 730                 735     


Asn Arg Lys Lys Gly Ser Pro Gly Leu Ala Ser Gly Ser Val Gly Gln 
            740                 745                 750         


Ser Pro Asn Ser Ala Pro Lys Ala Gly Leu Pro Gly Ala Thr Gly Pro 
        755                 760                 765             


Met Ala Val Arg Pro Glu Glu Ala Val Arg Gly Leu Gly Ala Gly Thr 
    770                 775                 780                 


Glu Ser Ser Arg Arg Ala Gln Glu Pro Val Ser Gly Cys Gly Ser Pro 
785                 790                 795                 800 


Glu Gln Asp Pro Gln Lys Gln Ala Glu Glu Glu Arg Gln Glu Glu Pro 
                805                 810                 815     


Glu Tyr Glu Asn Val Val Pro Ile Ser Arg Pro Pro Glu Pro 
            820                 825                 830 


