                         SEQUENCE LISTING

<110>  Universitt Heidelberg
 
<120>  Dll4 binding polypeptide and uses thereof

<130>  778-3 PCT

<150>  12 159 274.5

<151>  2012-03-13

<160>  80    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  binding polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid or absent

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Phe or Tyr

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Phe or Tyr

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Leu, Val or Ile

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Phe or Tyr

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Leu, Val or Ile

<400>  1

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  preferred amino acid sequence of the binding polypeptide

<400>  2

Leu Phe His Leu Phe Ile Tyr Ile 
1               5               


<210>  3
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scaffold protein comprising the polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Nle or Met

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is Phe or Tyr

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is Phe or Tyr

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Leu, Val or Ile

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Phe or Tyr

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Leu, Val or Ile

<400>  3

Leu Xaa Arg Cys Lys Gln Asp Ser Asp Cys Leu Ala Gly Ser Val Cys 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Phe Cys Gly 
            20                  25          


<210>  4
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scaffold protein comprising the polypeptide


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Phe or Tyr

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Phe or Tyr

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Leu, Val or Ile

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Phe or Tyr

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Leu, Val or Ile

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is Tyr or Phe

<400>  4

Gly Arg Cys Thr Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Xaa Pro Asp 
1               5                   10                  15      


<210>  5
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scaffold protein comprising the polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Nle or M

<400>  5

Leu Xaa Arg Cys Lys Gln Asp Ser Asp Cys Leu Ala Gly Ser Val Cys 
1               5                   10                  15      


Leu Phe His Leu Phe Ile Tyr Ile Phe Cys Gly 
            20                  25          


<210>  6
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scaffold protein comprising the polypeptide

<400>  6

Gly Arg Cys Thr Leu Phe His Leu Phe Ile Tyr Ile Cys Tyr Pro Asp 
1               5                   10                  15      


<210>  7
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scaffold protein comprising the polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Nle

<400>  7

Leu Xaa Arg Cys Lys Gln Asp Ser Asp Cys Leu Ala Gly Ser Val Cys 
1               5                   10                  15      


Leu Phe His Leu Phe Ile Tyr Ile Phe Cys Gly 
            20                  25          


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  8

Xaa Phe Xaa Xaa Phe Ile Tyr Ile 
1               5               


<210>  9
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  9

Xaa Tyr Xaa Xaa Phe Ile Tyr Ile 
1               5               


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  10

Xaa Phe Xaa Xaa Tyr Ile Tyr Ile 
1               5               


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  11

Xaa Tyr Xaa Xaa Tyr Ile Tyr Ile 
1               5               


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  12

Xaa Phe Xaa Xaa Phe Leu Tyr Ile 
1               5               


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  13

Xaa Tyr Xaa Xaa Phe Leu Tyr Ile 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  14

Xaa Phe Xaa Xaa Tyr Leu Tyr Ile 
1               5               


<210>  15
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  15

Xaa Tyr Xaa Xaa Tyr Leu Tyr Ile 
1               5               


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  16

Xaa Phe Xaa Xaa Phe Val Tyr Ile 
1               5               


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  17

Xaa Tyr Xaa Xaa Phe Val Tyr Ile 
1               5               


<210>  18
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  18

Xaa Phe Xaa Xaa Tyr Val Tyr Ile 
1               5               


<210>  19
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  19

Xaa Tyr Xaa Xaa Tyr Val Tyr Ile 
1               5               


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  20

Xaa Phe Xaa Xaa Phe Ile Phe Ile 
1               5               


<210>  21
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  21

Xaa Tyr Xaa Xaa Phe Ile Phe Ile 
1               5               


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  22

Xaa Phe Xaa Xaa Tyr Ile Phe Ile 
1               5               


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  23

Xaa Tyr Xaa Xaa Tyr Ile Phe Ile 
1               5               


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  24

Xaa Phe Xaa Xaa Phe Leu Phe Ile 
1               5               


<210>  25
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  25

Xaa Tyr Xaa Xaa Phe Leu Phe Ile 
1               5               


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  26

Xaa Phe Xaa Xaa Tyr Leu Phe Ile 
1               5               


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  27

Xaa Tyr Xaa Xaa Tyr Leu Phe Ile 
1               5               


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  28

Xaa Phe Xaa Xaa Phe Val Phe Ile 
1               5               


<210>  29
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  29

Xaa Tyr Xaa Xaa Phe Val Phe Ile 
1               5               


<210>  30
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  30

Xaa Phe Xaa Xaa Tyr Val Phe Ile 
1               5               


<210>  31
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  31

Xaa Tyr Xaa Xaa Tyr Val Phe Ile 
1               5               


<210>  32
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  32

Xaa Phe Xaa Xaa Phe Ile Tyr Leu 
1               5               


<210>  33
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  33

Xaa Tyr Xaa Xaa Phe Ile Tyr Leu 
1               5               


<210>  34
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  34

Xaa Phe Xaa Xaa Tyr Ile Tyr Leu 
1               5               


<210>  35
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  35

Xaa Tyr Xaa Xaa Tyr Ile Tyr Leu 
1               5               


<210>  36
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  36

Xaa Phe Xaa Xaa Phe Leu Tyr Leu 
1               5               


<210>  37
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  37

Xaa Tyr Xaa Xaa Phe Leu Tyr Leu 
1               5               


<210>  38
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  38

Xaa Phe Xaa Xaa Tyr Leu Tyr Leu 
1               5               


<210>  39
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  39

Xaa Tyr Xaa Xaa Tyr Leu Tyr Leu 
1               5               


<210>  40
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  40

Xaa Phe Xaa Xaa Phe Val Tyr Leu 
1               5               


<210>  41
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  41

Xaa Tyr Xaa Xaa Phe Val Tyr Leu 
1               5               


<210>  42
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  42

Xaa Phe Xaa Xaa Tyr Val Tyr Leu 
1               5               


<210>  43
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  43

Xaa Tyr Xaa Xaa Tyr Val Tyr Leu 
1               5               


<210>  44
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  44

Xaa Phe Xaa Xaa Phe Ile Phe Leu 
1               5               


<210>  45
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  45

Xaa Tyr Xaa Xaa Phe Ile Phe Leu 
1               5               


<210>  46
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  46

Xaa Phe Xaa Xaa Tyr Ile Phe Leu 
1               5               


<210>  47
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  47

Xaa Tyr Xaa Xaa Tyr Ile Phe Leu 
1               5               


<210>  48
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  48

Xaa Phe Xaa Xaa Phe Leu Phe Leu 
1               5               


<210>  49
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  49

Xaa Tyr Xaa Xaa Phe Leu Phe Leu 
1               5               


<210>  50
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  50

Xaa Phe Xaa Xaa Tyr Leu Phe Leu 
1               5               


<210>  51
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  51

Xaa Tyr Xaa Xaa Tyr Leu Phe Leu 
1               5               


<210>  52
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  52

Xaa Phe Xaa Xaa Phe Val Phe Leu 
1               5               


<210>  53
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  53

Xaa Tyr Xaa Xaa Phe Val Phe Leu 
1               5               


<210>  54
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  54

Xaa Phe Xaa Xaa Tyr Val Phe Leu 
1               5               


<210>  55
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  55

Xaa Tyr Xaa Xaa Tyr Val Phe Leu 
1               5               


<210>  56
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  56

Xaa Phe Xaa Xaa Phe Ile Tyr Val 
1               5               


<210>  57
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  57

Xaa Tyr Xaa Xaa Phe Ile Tyr Val 
1               5               


<210>  58
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  58

Xaa Phe Xaa Xaa Tyr Ile Tyr Val 
1               5               


<210>  59
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  59

Xaa Tyr Xaa Xaa Tyr Ile Tyr Val 
1               5               


<210>  60
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  60

Xaa Phe Xaa Xaa Phe Leu Tyr Val 
1               5               


<210>  61
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  61

Xaa Tyr Xaa Xaa Phe Leu Tyr Val 
1               5               


<210>  62
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  62

Xaa Phe Xaa Xaa Tyr Leu Tyr Val 
1               5               


<210>  63
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  63

Xaa Tyr Xaa Xaa Tyr Leu Tyr Val 
1               5               


<210>  64
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  64

Xaa Phe Xaa Xaa Phe Val Tyr Val 
1               5               


<210>  65
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  65

Xaa Tyr Xaa Xaa Phe Val Tyr Val 
1               5               


<210>  66
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  66

Xaa Phe Xaa Xaa Tyr Val Tyr Val 
1               5               


<210>  67
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  67

Xaa Tyr Xaa Xaa Tyr Val Tyr Val 
1               5               


<210>  68
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  68

Xaa Phe Xaa Xaa Phe Ile Phe Val 
1               5               


<210>  69
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  69

Xaa Tyr Xaa Xaa Phe Ile Phe Val 
1               5               


<210>  70
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  70

Xaa Phe Xaa Xaa Tyr Ile Phe Val 
1               5               


<210>  71
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  71

Xaa Tyr Xaa Xaa Tyr Ile Phe Val 
1               5               


<210>  72
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  72

Xaa Phe Xaa Xaa Phe Leu Phe Val 
1               5               


<210>  73
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  73

Xaa Tyr Xaa Xaa Phe Leu Phe Val 
1               5               


<210>  74
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  74

Xaa Phe Xaa Xaa Tyr Leu Phe Val 
1               5               


<210>  75
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  75

Xaa Tyr Xaa Xaa Tyr Leu Phe Val 
1               5               


<210>  76
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  76

Xaa Phe Xaa Xaa Phe Val Phe Val 
1               5               


<210>  77
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  77

Xaa Tyr Xaa Xaa Phe Val Phe Val 
1               5               


<210>  78
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  78

Xaa Phe Xaa Xaa Tyr Val Phe Val 
1               5               


<210>  79
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is any amino acid

<400>  79

Xaa Tyr Xaa Xaa Tyr Val Phe Val 
1               5               


<210>  80
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scaffold protein comprising the polypeptide

<400>  80

Gly Arg Cys Thr Leu Phe His Leu Phe Ile Tyr Ile Cys Phe Pro Asp 
1               5                   10                  15      


