                         SEQUENCE LISTING

<110>  Universitt Heidelberg
 
<120>  Dll4 binding polypeptides and uses thereof

<130>  778-2 PCT

<150>  EP 12 159 272.9

<151>  2012-03-13 

<160>  77    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  binding polypeptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Phe or Tyr

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Leu, Val or Ile

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Gln or Asn

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Ala or Val

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Leu, Val or Ile

<400>  1

Gly Trp Xaa Xaa Ser Xaa Trp Xaa Xaa His 
1               5                   10  


<210>  2
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  preferred amino acid sequence of the binding polypeptide

<400>  2

Gly Trp Tyr Ile Ser Asn Trp Ala Ile His 
1               5                   10  


<210>  3
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scaffold protein comprising the polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Nle or M

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Phe or Tyr

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Leu, Val or Ile

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Gln or Asn

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Ala or Val

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is Leu, Val or Ile

<400>  3

Leu Xaa Arg Cys Lys Gln Asp Ser Asp Cys Leu Ala Gly Ser Val Cys 
1               5                   10                  15      


Gly Trp Xaa Xaa Ser Xaa Trp Xaa Xaa His Phe Cys Gly 
            20                  25                  


<210>  4
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scaffold protein comprising the polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Nle or M

<400>  4

Leu Xaa Arg Cys Lys Gln Asp Ser Asp Cys Leu Ala Gly Ser Val Cys 
1               5                   10                  15      


Gly Trp Tyr Ile Ser Asn Trp Ala Ile His Phe Cys Gly 
            20                  25                  


<210>  5
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scaffold protein comprising the polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Nle

<400>  5

Leu Xaa Arg Cys Lys Gln Asp Ser Asp Cys Leu Ala Gly Ser Val Cys 
1               5                   10                  15      


Gly Trp Tyr Ile Ser Asn Trp Ala Ile His Phe Cys Gly 
            20                  25                  


<210>  6
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  6

Gly Trp Phe Leu Ser Gln Trp Ala Leu His 
1               5                   10  


<210>  7
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  7

Gly Trp Tyr Leu Ser Gln Trp Ala Leu His 
1               5                   10  


<210>  8
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  8

Gly Trp Phe Val Ser Gln Trp Ala Leu His 
1               5                   10  


<210>  9
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  9

Gly Trp Tyr Val Ser Gln Trp Ala Leu His 
1               5                   10  


<210>  10
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  10

Gly Trp Phe Ile Ser Gln Trp Ala Leu His 
1               5                   10  


<210>  11
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  11

Gly Trp Tyr Ile Ser Gln Trp Ala Leu His 
1               5                   10  


<210>  12
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  12

Gly Trp Phe Leu Ser Asn Trp Ala Leu His 
1               5                   10  


<210>  13
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  13

Gly Trp Tyr Leu Ser Asn Trp Ala Leu His 
1               5                   10  


<210>  14
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  14

Gly Trp Phe Val Ser Asn Trp Ala Leu His 
1               5                   10  


<210>  15
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  15

Gly Trp Tyr Val Ser Asn Trp Ala Leu His 
1               5                   10  


<210>  16
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  16

Gly Trp Phe Ile Ser Asn Trp Ala Leu His 
1               5                   10  


<210>  17
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  17

Gly Trp Tyr Ile Ser Asn Trp Ala Leu His 
1               5                   10  


<210>  18
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  18

Gly Trp Phe Leu Ser Gln Trp Val Leu His 
1               5                   10  


<210>  19
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  19

Gly Trp Tyr Leu Ser Gln Trp Val Leu His 
1               5                   10  


<210>  20
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  20

Gly Trp Phe Val Ser Gln Trp Val Leu His 
1               5                   10  


<210>  21
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  21

Gly Trp Tyr Val Ser Gln Trp Val Leu His 
1               5                   10  


<210>  22
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  22

Gly Trp Phe Ile Ser Gln Trp Val Leu His 
1               5                   10  


<210>  23
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  23

Gly Trp Tyr Ile Ser Gln Trp Val Leu His 
1               5                   10  


<210>  24
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  24

Gly Trp Phe Leu Ser Asn Trp Val Leu His 
1               5                   10  


<210>  25
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  25

Gly Trp Tyr Leu Ser Asn Trp Val Leu His 
1               5                   10  


<210>  26
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  26

Gly Trp Phe Val Ser Asn Trp Val Leu His 
1               5                   10  


<210>  27
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  27

Gly Trp Tyr Val Ser Asn Trp Val Leu His 
1               5                   10  


<210>  28
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  28

Gly Trp Phe Ile Ser Asn Trp Val Leu His 
1               5                   10  


<210>  29
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  29

Gly Trp Tyr Ile Ser Asn Trp Val Leu His 
1               5                   10  


<210>  30
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  30

Gly Trp Phe Leu Ser Gln Trp Ala Val His 
1               5                   10  


<210>  31
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  31

Gly Trp Tyr Leu Ser Gln Trp Ala Val His 
1               5                   10  


<210>  32
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  32

Gly Trp Phe Val Ser Gln Trp Ala Val His 
1               5                   10  


<210>  33
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  33

Gly Trp Tyr Val Ser Gln Trp Ala Val His 
1               5                   10  


<210>  34
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  34

Gly Trp Phe Ile Ser Gln Trp Ala Val His 
1               5                   10  


<210>  35
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  35

Gly Trp Tyr Ile Ser Gln Trp Ala Val His 
1               5                   10  


<210>  36
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  36

Gly Trp Phe Leu Ser Asn Trp Ala Val His 
1               5                   10  


<210>  37
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  37

Gly Trp Tyr Leu Ser Asn Trp Ala Val His 
1               5                   10  


<210>  38
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  38

Gly Trp Phe Val Ser Asn Trp Ala Val His 
1               5                   10  


<210>  39
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  39

Gly Trp Tyr Val Ser Asn Trp Ala Val His 
1               5                   10  


<210>  40
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  40

Gly Trp Phe Ile Ser Asn Trp Ala Val His 
1               5                   10  


<210>  41
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  41

Gly Trp Tyr Ile Ser Asn Trp Ala Val His 
1               5                   10  


<210>  42
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  42

Gly Trp Phe Leu Ser Gln Trp Val Val His 
1               5                   10  


<210>  43
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  43

Gly Trp Tyr Leu Ser Gln Trp Val Val His 
1               5                   10  


<210>  44
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  44

Gly Trp Phe Val Ser Gln Trp Val Val His 
1               5                   10  


<210>  45
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  45

Gly Trp Tyr Val Ser Gln Trp Val Val His 
1               5                   10  


<210>  46
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  46

Gly Trp Phe Ile Ser Gln Trp Val Val His 
1               5                   10  


<210>  47
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  47

Gly Trp Tyr Ile Ser Gln Trp Val Val His 
1               5                   10  


<210>  48
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  48

Gly Trp Phe Leu Ser Asn Trp Val Val His 
1               5                   10  


<210>  49
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  49

Gly Trp Tyr Leu Ser Asn Trp Val Val His 
1               5                   10  


<210>  50
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  50

Gly Trp Phe Val Ser Asn Trp Val Val His 
1               5                   10  


<210>  51
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  51

Gly Trp Tyr Val Ser Asn Trp Val Val His 
1               5                   10  


<210>  52
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  52

Gly Trp Phe Ile Ser Asn Trp Val Val His 
1               5                   10  


<210>  53
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  53

Gly Trp Tyr Ile Ser Asn Trp Val Val His 
1               5                   10  


<210>  54
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  54

Gly Trp Phe Leu Ser Gln Trp Ala Ile His 
1               5                   10  


<210>  55
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  55

Gly Trp Tyr Leu Ser Gln Trp Ala Ile His 
1               5                   10  


<210>  56
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  56

Gly Trp Phe Val Ser Gln Trp Ala Ile His 
1               5                   10  


<210>  57
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  57

Gly Trp Tyr Val Ser Gln Trp Ala Ile His 
1               5                   10  


<210>  58
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  58

Gly Trp Phe Ile Ser Gln Trp Ala Ile His 
1               5                   10  


<210>  59
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  59

Gly Trp Tyr Ile Ser Gln Trp Ala Ile His 
1               5                   10  


<210>  60
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  60

Gly Trp Phe Leu Ser Asn Trp Ala Ile His 
1               5                   10  


<210>  61
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  61

Gly Trp Tyr Leu Ser Asn Trp Ala Ile His 
1               5                   10  


<210>  62
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  62

Gly Trp Phe Val Ser Asn Trp Ala Ile His 
1               5                   10  


<210>  63
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  63

Gly Trp Tyr Val Ser Asn Trp Ala Ile His 
1               5                   10  


<210>  64
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  64

Gly Trp Phe Ile Ser Asn Trp Ala Ile His 
1               5                   10  


<210>  65
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  65

Gly Trp Tyr Ile Ser Asn Trp Ala Ile His 
1               5                   10  


<210>  66
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  66

Gly Trp Phe Leu Ser Gln Trp Val Ile His 
1               5                   10  


<210>  67
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  67

Gly Trp Tyr Leu Ser Gln Trp Val Ile His 
1               5                   10  


<210>  68
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  68

Gly Trp Phe Val Ser Gln Trp Val Ile His 
1               5                   10  


<210>  69
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  69

Gly Trp Tyr Val Ser Gln Trp Val Ile His 
1               5                   10  


<210>  70
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  70

Gly Trp Phe Ile Ser Gln Trp Val Ile His 
1               5                   10  


<210>  71
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  71

Gly Trp Tyr Ile Ser Gln Trp Val Ile His 
1               5                   10  


<210>  72
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  72

Gly Trp Phe Leu Ser Asn Trp Val Ile His 
1               5                   10  


<210>  73
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  73

Gly Trp Tyr Leu Ser Asn Trp Val Ile His 
1               5                   10  


<210>  74
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  74

Gly Trp Phe Val Ser Asn Trp Val Ile His 
1               5                   10  


<210>  75
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  75

Gly Trp Tyr Val Ser Asn Trp Val Ile His 
1               5                   10  


<210>  76
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  76

Gly Trp Phe Ile Ser Asn Trp Val Ile His 
1               5                   10  


<210>  77
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide variant

<400>  77

Gly Trp Tyr Ile Ser Asn Trp Val Ile His 
1               5                   10  


