                               SEQUENCE LISTING

<110> NORTHEASTERN UNIVERSITY
      COPERNICUS THERAPEUTICS, INC.
 
<120> METHODS FOR DELIVERY TO THE CENTRAL NERVOUS SYSTEM OF NUCLEIC 
      ACID NANOPARTICLES TO TREAT CENTRAL NERVOUS SYSTEM DISORDERS

<130> 0067403.00403WO1

<140> PCT/US2013/030264
<141> 2013-03-11

<150> 61/768,895
<151> 2013-02-25

<150> 61/725,662
<151> 2012-11-13

<150> 61/609,042
<151> 2012-03-09

<160> 2     

<170> PatentIn version 3.5

<210> 1
<211> 4064
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1
ttaattaaaa ttatctctaa ggcatgtgaa ctggctgtct tggttttcat ctgtacttca       60

tctgctacct ctgtgacctg aaacatattt ataattccat taagctgtgc atatgataga      120

tttatcatat gtattttcct taaaggattt ttgtaagaac taattgaatt gatacctgta      180

aagtctttat cacactaccc aataaataat aaatctcttt gttcagctct ctgtttctat      240

aaatatgtac cagttttatt gtttttagtg gtagtgattt tattctcttt ctatatatat      300

acacacacat gtgtgcattc ataaatatat acaattttta tgaataaaaa attattagca      360

atcaatattg aaaaccactg atttttgttt atgtgagcaa acagcagatt aaaaggaatt      420

cctgcaggcc tccgcgccgg gttttggcgc ctcccgcggg cgcccccctc ctcacggcga      480

gcgctgccac gtcagacgaa gggcgcagcg agcgtcctga tccttccgcc cggacgctca      540

ggacagcggc ccgctgctca taagactcgg ccttagaacc ccagtatcag cagaaggaca      600

ttttaggacg ggacttgggt gactctaggg cactggtttt ctttccagag agcggaacag      660

gcgaggaaaa gtagtccctt ctcggcgatt ctgcggaggg atctccgtgg ggcggtgaac      720

gccgatgatt atataaggac gcgccgggtg tggcacagct agttccgtcg cagccgggat      780

ttgggtcgcg gttcttgttt gtggatcgct gtgatcgtca cttggtgagt agcgggctgc      840

tgggctggcc ggggctttcg tggccgccgg gccgctcggt gggacggaag cgtgtggaga      900

gaccgccaag ggctgtagtc tgggtccgcg agcaaggttg ccctgaactg ggggttgggg      960

ggagcgcagc aaaatggcgg ctgttcccga gtcttgaatg gaagacgctt gtgaggcggg     1020

ctgtgaggtc gttgaaacaa ggtggggggc atggtgggcg gcaagaaccc aaggtcttga     1080

ggccttcgct aatgcgggaa agctcttatt cgggtgagat gggctgtggc accatctggg     1140

gaccctgacg tgaagtttgt cactgactgg agaactcggt ttgtcgtctg ttgcgggggc     1200

ggcagttatg gcggtgccgt tgggcagtgc acccgtacct ttgggagcgc gcgccctcgt     1260

cgtgtcgtga cgtcacccgt tctgttggct tataatgcag ggtggggcca cctgccggta     1320

ggtgtgcggt aggcttttct ccgtcgcagg acgcagggtt cgggcctagg gtaggctctc     1380

ctgaatcgac aggcgccgga cctctggtga ggggagggat aagtgaggcg tcagtttctt     1440

tggtcggttt tatgtaccta tcttcttaag tagctgaagc tccggttttg aactatgcgc     1500

tcggggttgg cgagtgtgtt ttgtgaagtt ttttaggcac cttttgaaat gtaatcattt     1560

gggtcaatat gtaattttca gtgttagact agtaaattgt ccgctaaatt ctggccgttt     1620

ttggcttttt tgttagacga gctagcccac catgaagtta tgggatgtcg tggctgtctg     1680

cctggtgctg ctccacaccg cgtccgcctt cccgctgccc gccggcaaga ggcctcccga     1740

ggcgcccgcc gaagaccgct ccctcggccg ccgccgcgcg cccttcgcgc tgagcagtga     1800

ctcaaatatg ccagaggatt atcctgatca gttcgatgat gtcatggatt ttattcaagc     1860

caccattaaa agactgaaaa ggtcaccaga taaacaaatg gcagtgcttc ctagaagaga     1920

gcggaatcgg caggctgcag ctgccaaccc agagaattcc agaggaaaag gtcggagagg     1980

ccagaggggc aaaaaccggg gttgtgtctt aactgcaata catttaaatg tcactgactt     2040

gggtctgggc tatgaaacca aggaggaact gatttttagg tactgcagcg gctcttgcga     2100

tgcagctgag acaacgtacg acaaaatatt gaaaaactta tccagaaata gaaggctggt     2160

gagtgacaaa gtagggcagg catgttgcag acccatcgcc tttgatgatg acctgtcgtt     2220

tttagatgat aacctggttt accatattct aagaaagcat tccgctaaaa ggtgtggatg     2280

tatctgataa tctagactag ctggccagac atgataagat acattgatga gtttggacaa     2340

accacaacta gaatgcagtg aaaaaaatgc tttatttgtg aaatttgtga tgctattgct     2400

ttatttgtaa ccattataag ctgcaataaa caagttaaca acaacaattg cattcatttt     2460

atgtttcagg ttcaggggga ggtgtgggag gttttttaaa gcaagtaaaa cctctacaaa     2520

tgtggtatgg aattcagtca atatgttcac cccaaaaaag ctgtttgtta acttgccaac     2580

ctcattctaa aatgtatata gaagcccaaa agacaataac aaaaatattc ttgtagaaca     2640

aaatgggaaa gaatgttcca ctaaatatca agatttagag caaagcatga gatgtgtggg     2700

gatagacagt gaggctgata aaatagagta gagctcagaa acagacccat tgatatatgt     2760

aagtgaccta tgaaaaaaat atggcatttt acaatgggaa aatgatgatc tttttctttt     2820

ttagaaaaac agggaaatat atttatatgt aaaaaataaa agggaaccca tatgtcatac     2880

catacacaca aaaaaattcc agtgaattat aagtctaaat ggagaaggca aaactttaaa     2940

tcttttagaa aataatatag aagcatgcca tcaagacttc agtgtagaga aaaatttctt     3000

atgactcaaa gtcctaacca caaagaaaag attgttaatt agattgcatg aatattaaga     3060

cttattttta aaattaaaaa accattaaga aaagtcaggc catagaatga cagaaaatat     3120

ttgcaacacc ccagtaaaga gaattgtaat atgcagatta taaaaagaag tcttacaaat     3180

cagtaaaaaa taaaactaga caaaaatttg aacagatgaa agagaaactc taaataatca     3240

ttacacatga gaaactcaat ctcagaaatc agagaactat cattgcatat acactaaatt     3300

agagaaatat taaaaggcta agtaacatct gtggcttaat taaaacagta gttgacaatt     3360

aaacattggc atagtatatc tgcatagtat aatacaactc actataggag ggccatcatg     3420

gccaagttga ccagtgctgt cccagtgctc acagccaggg atgtggctgg agctgttgag     3480

ttctggactg acaggttggg gttctccaga gattttgtgg aggatgactt tgcaggtgtg     3540

gtcagagatg atgtcaccct gttcatctca gcagtccagg accaggtggt gcctgacaac     3600

accctggctt gggtgtgggt gagaggactg gatgagctgt atgctgagtg gagtgaggtg     3660

gtctccacca acttcaggga tgccagtggc cctgccatga cagagattgg agagcagccc     3720

tgggggagag agtttgccct gagagaccca gcaggcaact gtgtgcactt tgtggcagag     3780

gagcaggact gaggataacc taggaaacct taaaaccttt aaaagcctta tatattcttt     3840

tttttcttat aaaacttaaa accttagagg ctatttaagt tgctgattta tattaatttt     3900

attgttcaaa catgagagct tagtacatga aacatgagag cttagtacat tagccatgag     3960

agcttagtac attagccatg agggtttagt tcattaaaca tgagagctta gtacattaaa     4020

catgagagct tagtacatac tatcaacagg ttgaactgct gatc                      4064


<210> 2
<211> 211
<212> PRT
<213> Homo sapiens

<400> 2
Met Lys Leu Trp Asp Val Val Ala Val Cys Leu Val Leu Leu His Thr 
1               5                   10                  15      


Ala Ser Ala Phe Pro Leu Pro Ala Gly Lys Arg Pro Pro Glu Ala Pro 
            20                  25                  30          


Ala Glu Asp Arg Ser Leu Gly Arg Arg Arg Ala Pro Phe Ala Leu Ser 
        35                  40                  45              


Ser Asp Ser Asn Met Pro Glu Asp Tyr Pro Asp Gln Phe Asp Asp Val 
    50                  55                  60                  


Met Asp Phe Ile Gln Ala Thr Ile Lys Arg Leu Lys Arg Ser Pro Asp 
65                  70                  75                  80  


Lys Gln Met Ala Val Leu Pro Arg Arg Glu Arg Asn Arg Gln Ala Ala 
                85                  90                  95      


Ala Ala Asn Pro Glu Asn Ser Arg Gly Lys Gly Arg Arg Gly Gln Arg 
            100                 105                 110         


Gly Lys Asn Arg Gly Cys Val Leu Thr Ala Ile His Leu Asn Val Thr 
        115                 120                 125             


Asp Leu Gly Leu Gly Tyr Glu Thr Lys Glu Glu Leu Ile Phe Arg Tyr 
    130                 135                 140                 


Cys Ser Gly Ser Cys Asp Ala Ala Glu Thr Thr Tyr Asp Lys Ile Leu 
145                 150                 155                 160 


Lys Asn Leu Ser Arg Asn Arg Arg Leu Val Ser Asp Lys Val Gly Gln 
                165                 170                 175     


Ala Cys Cys Arg Pro Ile Ala Phe Asp Asp Asp Leu Ser Phe Leu Asp 
            180                 185                 190         


Asp Asn Leu Val Tyr His Ile Leu Arg Lys His Ser Ala Lys Arg Cys 
        195                 200                 205             


Gly Cys Ile 
    210     


