                         SEQUENCE LISTING

<110>  UCL Business PLC
 
<120>  Treatment of cancer

<130>  N.116113B

<150>  US 61/608,872
<151>  2012-03-09

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  1780
<212>  DNA
<213>  Homo sapiens

<400>  1
gcagagctac catgtcctct tggagcagac agcgaccaaa aagcccaggg ggcattcaac       60

cccatgtttc tagaactctg ttcctgctgc tgctgttggc agcctcagcc tggggggtca      120

ccctgagccc caaagactgc caggtgttcc gctcagacca tggcagctcc atctcctgtc      180

aaccacctgc cgaaatcccc ggctacctgc cagccgacac cgtgcacctg gccgtggaat      240

tcttcaacct gacccacctg ccagccaacc tcctccaggg cgcctctaag ctccaagaat      300

tgcacctctc cagcaatggg ctggaaagcc tctcgcccga attcctgcgg ccagtgccgc      360

agctgagggt gctggatcta acccgaaacg ccctgaccgg gctgcccccg ggcctcttcc      420

aggcctcagc caccctggac accctggtat tgaaagaaaa ccagctggag gtcctggagg      480

tctcgtggct acacggcctg aaagctctgg ggcatctgga cctgtctggg aaccgcctcc      540

ggaaactgcc ccccgggctg ctggccaact tcaccctcct gcgcaccctt gaccttgggg      600

agaaccagtt ggagaccttg ccacctgacc tcctgagggg tccgctgcaa ttagaacggc      660

tacatctaga aggcaacaaa ttgcaagtac tgggaaaaga tctcctcttg ccgcagccgg      720

acctgcgcta cctcttcctg aacggcaaca agctggccag ggtggcagcc ggtgccttcc      780

agggcctgcg gcagctggac atgctggacc tctccaataa ctcactggcc agcgtgcccg      840

aggggctctg ggcatcccta gggcagccaa actgggacat gcgggatggc ttcgacatct      900

ccggcaaccc ctggatctgt gaccagaacc tgagcgacct ctatcgttgg cttcaggccc      960

aaaaagacaa gatgttttcc cagaatgaca cgcgctgtgc tgggcctgaa gccgtgaagg     1020

gccagacgct cctggcagtg gccaagtccc agtgagacca ggggcttggg ttgagggtgg     1080

ggggtctggt agaacactgc aacccgctta acaaataatc ctgcctttgg ccgggtgcgg     1140

gggctcacgc ctgtaatccc agcactttgg gaggcccagg tgggcggatc acgaggtcag     1200

gagatcgaga ccatcttggc taacatggtg aaaccctgtc tctactaaaa atataaaaaa     1260

ttagccaggc gtggtggtgg gcacctgtag tcccagcaac tcgggaggct gaggcaggag     1320

aatggcgtga acttgggagg cggagcttgc ggtgagccaa gatcgtgcca ctgcactcta     1380

gcctgggcga cagagcaaga ctgtctcaaa aaaattaaaa ttaaaattaa aaacaaataa     1440

tcctgccttt tacaggtgaa actcggggct gtccatagcg gctgggaccc cgtttcatcc     1500

atccatgctt cctagaacac acgatgggct ttccttaccc atgcccaagg tgtgccctcc     1560

gtctggaatg ccgttccctg tttcccagat ctcttgaact ctgggttctc ccagcccctt     1620

gtccttcctt ccagctgagc cctggccaca ctggggctgc ctttctctga ctctgtcttc     1680

cccaagtcag ggggctctct gagtgcaggg tctgatgctg agtcccactt agcttggggt     1740

cagaaccaag gggtttaata aataaccctt gaaaactgga                           1780


<210>  2
<211>  347
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Ser Trp Ser Arg Gln Arg Pro Lys Ser Pro Gly Gly Ile Gln 
1               5                   10                  15      


Pro His Val Ser Arg Thr Leu Phe Leu Leu Leu Leu Leu Ala Ala Ser 
            20                  25                  30          


Ala Trp Gly Val Thr Leu Ser Pro Lys Asp Cys Gln Val Phe Arg Ser 
        35                  40                  45              


Asp His Gly Ser Ser Ile Ser Cys Gln Pro Pro Ala Glu Ile Pro Gly 
    50                  55                  60                  


Tyr Leu Pro Ala Asp Thr Val His Leu Ala Val Glu Phe Phe Asn Leu 
65                  70                  75                  80  


Thr His Leu Pro Ala Asn Leu Leu Gln Gly Ala Ser Lys Leu Gln Glu 
                85                  90                  95      


Leu His Leu Ser Ser Asn Gly Leu Glu Ser Leu Ser Pro Glu Phe Leu 
            100                 105                 110         


Arg Pro Val Pro Gln Leu Arg Val Leu Asp Leu Thr Arg Asn Ala Leu 
        115                 120                 125             


Thr Gly Leu Pro Pro Gly Leu Phe Gln Ala Ser Ala Thr Leu Asp Thr 
    130                 135                 140                 


Leu Val Leu Lys Glu Asn Gln Leu Glu Val Leu Glu Val Ser Trp Leu 
145                 150                 155                 160 


His Gly Leu Lys Ala Leu Gly His Leu Asp Leu Ser Gly Asn Arg Leu 
                165                 170                 175     


Arg Lys Leu Pro Pro Gly Leu Leu Ala Asn Phe Thr Leu Leu Arg Thr 
            180                 185                 190         


Leu Asp Leu Gly Glu Asn Gln Leu Glu Thr Leu Pro Pro Asp Leu Leu 
        195                 200                 205             


Arg Gly Pro Leu Gln Leu Glu Arg Leu His Leu Glu Gly Asn Lys Leu 
    210                 215                 220                 


Gln Val Leu Gly Lys Asp Leu Leu Leu Pro Gln Pro Asp Leu Arg Tyr 
225                 230                 235                 240 


Leu Phe Leu Asn Gly Asn Lys Leu Ala Arg Val Ala Ala Gly Ala Phe 
                245                 250                 255     


Gln Gly Leu Arg Gln Leu Asp Met Leu Asp Leu Ser Asn Asn Ser Leu 
            260                 265                 270         


Ala Ser Val Pro Glu Gly Leu Trp Ala Ser Leu Gly Gln Pro Asn Trp 
        275                 280                 285             


Asp Met Arg Asp Gly Phe Asp Ile Ser Gly Asn Pro Trp Ile Cys Asp 
    290                 295                 300                 


Gln Asn Leu Ser Asp Leu Tyr Arg Trp Leu Gln Ala Gln Lys Asp Lys 
305                 310                 315                 320 


Met Phe Ser Gln Asn Asp Thr Arg Cys Ala Gly Pro Glu Ala Val Lys 
                325                 330                 335     


Gly Gln Thr Leu Leu Ala Val Ala Lys Ser Gln 
            340                 345         


<210>  3
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  3

Leu Gln Glu Leu His Leu Ser Ser Asn Gly Leu Glu Ser Leu Ser Pro 
1               5                   10                  15      


Glu Phe Leu Arg Pro Val Pro Gln 
            20                  


<210>  4
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  4

Leu Asp Met Leu Asp Leu Ser Asn Asn Ser Leu Ala Ser Val Pro Glu 
1               5                   10                  15      


Gly Leu Trp Ala Ser Leu Gly Gln 
            20                  


<210>  5
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  5

Lys Met Phe Ser Gln Asn Asp Thr Arg Cys Ala Gly Pro Glu Ala Val 
1               5                   10                  15      


Lys Gly Gln Thr Leu Leu Ala Val Ala Lys 
            20                  25      


<210>  6
<211>  342
<212>  PRT
<213>  Mus musculus

<400>  6

Met Val Ser Trp Gln His Gln Gly Ser Leu Gln Asp Leu Lys Thr Cys 
1               5                   10                  15      


Leu Ala Arg Thr Leu Phe Leu Leu Ala Leu Leu Gly Arg Val Ser Ser 
            20                  25                  30          


Leu Lys Glu Cys Leu Ile Leu Gln Ser Ala Glu Gly Ser Thr Val Ser 
        35                  40                  45              


Cys His Gly Pro Thr Glu Phe Pro Ser Ser Leu Pro Ala Asp Thr Val 
    50                  55                  60                  


His Leu Ser Val Glu Phe Ser Asn Leu Thr Gln Leu Pro Ala Ala Ala 
65                  70                  75                  80  


Leu Gln Gly Cys Pro Gly Leu Arg Glu Leu His Leu Ser Ser Asn Arg 
                85                  90                  95      


Leu Gln Ala Leu Ser Pro Glu Leu Leu Ala Pro Val Pro Arg Leu Arg 
            100                 105                 110         


Ala Leu Asp Leu Thr Arg Asn Ala Leu Arg Ser Leu Pro Pro Gly Leu 
        115                 120                 125             


Phe Ser Thr Ser Ala Asn Leu Ser Thr Leu Val Leu Arg Glu Asn Gln 
    130                 135                 140                 


Leu Arg Glu Val Ser Ala Gln Trp Leu Gln Gly Leu Asp Ala Leu Gly 
145                 150                 155                 160 


His Leu Asp Leu Ala Glu Asn Gln Leu Ser Ser Leu Pro Ser Gly Leu 
                165                 170                 175     


Leu Ala Ser Leu Gly Ala Leu His Thr Leu Asp Leu Gly Tyr Asn Leu 
            180                 185                 190         


Leu Glu Ser Leu Pro Glu Gly Leu Leu Arg Gly Pro Arg Arg Leu Gln 
        195                 200                 205             


Arg Leu His Leu Glu Gly Asn Arg Leu Gln Arg Leu Glu Asp Ser Leu 
    210                 215                 220                 


Leu Ala Pro Gln Pro Phe Leu Arg Val Leu Phe Leu Asn Asp Asn Gln 
225                 230                 235                 240 


Leu Val Gly Val Ala Thr Gly Ser Phe Gln Gly Leu Gln His Leu Asp 
                245                 250                 255     


Met Leu Asp Leu Ser Asn Asn Ser Leu Ser Ser Thr Pro Pro Gly Leu 
            260                 265                 270         


Trp Ala Phe Leu Gly Arg Pro Thr Arg Asp Met Gln Asp Gly Phe Asp 
        275                 280                 285             


Ile Ser His Asn Pro Trp Ile Cys Asp Lys Asn Leu Ala Asp Leu Cys 
    290                 295                 300                 


Arg Trp Leu Val Ala Asn Arg Asn Lys Met Phe Ser Gln Asn Asp Thr 
305                 310                 315                 320 


Arg Cys Ala Gly Pro Glu Ala Met Lys Gly Gln Arg Leu Leu Asp Val 
                325                 330                 335     


Ala Glu Leu Gly Ser Leu 
            340         


<210>  7
<211>  248
<212>  PRT
<213>  Mus musculus

<400>  7

His Leu Ser Ser Asn Arg Leu Gln Ala Leu Ser Pro Glu Leu Leu Ala 
1               5                   10                  15      


Pro Val Pro Arg Leu Arg Ala Leu Asp Leu Thr Arg Asn Ala Leu Arg 
            20                  25                  30          


Ser Leu Pro Pro Gly Leu Phe Ser Thr Ser Ala Asn Leu Ser Thr Leu 
        35                  40                  45              


Val Leu Arg Glu Asn Gln Leu Arg Glu Val Ser Ala Gln Trp Leu Gln 
    50                  55                  60                  


Gly Leu Asp Ala Leu Gly His Leu Asp Leu Ala Glu Asn Gln Leu Ser 
65                  70                  75                  80  


Ser Leu Pro Ser Gly Leu Leu Ala Ser Leu Gly Ala Leu His Thr Leu 
                85                  90                  95      


Asp Leu Gly Tyr Asn Leu Leu Glu Ser Leu Pro Glu Gly Leu Leu Arg 
            100                 105                 110         


Gly Pro Arg Arg Leu Gln Arg Leu His Leu Glu Gly Asn Arg Leu Gln 
        115                 120                 125             


Arg Leu Glu Asp Ser Leu Leu Ala Pro Gln Pro Phe Leu Arg Val Leu 
    130                 135                 140                 


Phe Leu Asn Asp Asn Gln Leu Val Gly Val Ala Thr Gly Ser Phe Gln 
145                 150                 155                 160 


Gly Leu Gln His Leu Asp Met Leu Asp Leu Ser Asn Asn Ser Leu Ser 
                165                 170                 175     


Ser Thr Pro Pro Gly Leu Trp Ala Phe Leu Gly Arg Pro Thr Arg Asp 
            180                 185                 190         


Met Gln Asp Gly Phe Asp Ile Ser His Asn Pro Trp Ile Cys Asp Lys 
        195                 200                 205             


Asn Leu Ala Asp Leu Cys Arg Trp Leu Val Ala Asn Arg Asn Lys Met 
    210                 215                 220                 


Phe Ser Gln Asn Asp Thr Arg Cys Ala Gly Pro Glu Ala Met Lys Gly 
225                 230                 235                 240 


Gln Arg Leu Leu Asp Val Ala Glu 
                245             


<210>  8
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  8

Leu Gln Glu Leu His Leu Ser Ser Asn Gly Leu Glu Ser Leu Ser Pro 
1               5                   10                  15      


Glu Phe Leu Arg Pro Val Pro Gln Leu Arg Val Leu Asp Leu Thr Arg 
            20                  25                  30          


Asn Ala Leu Thr Gly Leu Pro Pro Gly Leu Phe Gln Ala Ser Ala Thr 
        35                  40                  45              


Leu Asp Thr Leu Val Leu Lys Glu Asn Gln Leu Glu Val Leu Glu Val 
    50                  55                  60                  


Ser Trp Leu His Gly Leu Lys Ala Leu Gly His Leu Asp Leu Ser Gly 
65                  70                  75                  80  


Asn Arg Leu Arg Lys Leu Pro Pro Gly Leu Leu Ala Asn Phe Thr Leu 
                85                  90                  95      


Leu Arg Thr Leu Asp Leu Gly Glu Asn Gln Leu Glu Thr Leu Pro Pro 
            100                 105                 110         


Asp Leu Leu Arg Gly Pro Leu Gln Leu Glu Arg Leu His Leu Glu Gly 
        115                 120                 125             


Asn Lys Leu Gln Val Leu Gly Lys Asp Leu Leu Leu Pro Gln Pro Asp 
    130                 135                 140                 


Leu Arg Tyr Leu Phe Leu Asn Gly Asn Lys Leu Ala Arg Val Ala Ala 
145                 150                 155                 160 


Gly Ala Phe Gln Gly Leu Arg Gln Leu Asp Met Leu Asp Leu Ser Asn 
                165                 170                 175     


Asn Ser Leu Ala Ser Val Pro Glu Gly Leu Trp Ala Ser Leu Gly Gln 
            180                 185                 190         


Pro Asn Trp Asp Met Arg Asp Gly Phe Asp Ile Ser Gly Asn Pro Trp 
        195                 200                 205             


Ile Cys Asp Gln Asn Leu Ser Asp Leu Tyr Arg Trp Leu Gln Ala Gln 
    210                 215                 220                 


Lys Asp Lys Met Phe Ser Gln Asn Asp Thr Arg Cys Ala Gly Pro Glu 
225                 230                 235                 240 


Ala Val Lys Gly Gln Thr Leu Leu Ala Val Ala Lys 
                245                 250         


