﻿               SEQUENCE LISTING

<110> Thommen Medical AG

<120> Device for the diagnosis of inflammatory tissues in dental applications

<160> 47

<170> BiSSAP 1.2

<210> 1
<211> 8
<212> PRT
<213> Homo sapiens


<400> 1
Gly Pro Gln Gly Ile Ala Gly Gln 
1               5               

<210> 2
<211> 8
<212> PRT
<213> Homo sapiens


<400> 2
Gly Asn Gln Gly Ile Ala Gly Gln 
1               5               

<210> 3
<211> 8
<212> PRT
<213> Homo sapiens


<400> 3
Gly Leu Gln Gly Ile Ala Gly Gln 
1               5               

<210> 4
<211> 8
<212> PRT
<213> Homo sapiens


<400> 4
Gly Pro Asp Gly Ile Ala Gly Gln 
1               5               

<210> 5
<211> 8
<212> PRT
<213> Homo sapiens


<400> 5
Gly Pro Leu Gly Ile Ala Gly Gln 
1               5               

<210> 6
<211> 8
<212> PRT
<213> Homo sapiens


<400> 6
Gly Pro Gln Glu Ile Ala Gly Gln 
1               5               

<210> 7
<211> 8
<212> PRT
<213> Homo sapiens


<400> 7
Gly Pro Gln Phe Ile Ala Gly Gln 
1               5               

<210> 8
<211> 8
<212> PRT
<213> Homo sapiens


<400> 8
Gly Pro Gln Arg Ile Ala Gly Gln 
1               5               

<210> 9
<211> 8
<212> PRT
<213> Homo sapiens


<400> 9
Gly Pro Gln Gly Leu Ala Gly Gln 
1               5               

<210> 10
<211> 8
<212> PRT
<213> Homo sapiens


<400> 10
Gly Pro Gln Gly Tyr Ala Gly Gln 
1               5               

<210> 11
<211> 8
<212> PRT
<213> Homo sapiens


<400> 11
Gly Pro Gln Gly Ile Phe Gly Gln 
1               5               

<210> 12
<211> 8
<212> PRT
<213> Homo sapiens


<400> 12
Gly Pro Gln Gly Ile Glu Gly Gln 
1               5               

<210> 13
<211> 19
<212> PRT
<213> Homo sapiens


<400> 13
Ala Ser Gln Lys Arg Pro Ser Gln Arg His Gly Ser Lys Tyr Leu Ala 
1               5                   10                  15      
Thr Ala Ser 
            

<210> 14
<211> 16
<212> PRT
<213> Homo sapiens


<400> 14
Ala Ser Gln Lys Arg Pro Gln Arg Ser Lys Tyr Leu Ala Thr Ala Ser 
1               5                   10                  15      



<210> 15
<211> 5
<212> PRT
<213> Homo sapiens

<220> 
<223> Ac-Pro-Leu-Gly-(2-mercapto-4-methyl-pentanoly)-Leu-Gly-OEt

<400> 15
Pro Leu Gly Leu Gly 
1               5   

<210> 16
<211> 6
<212> PRT
<213> Homo sapiens

<220> 
<223> Ac-Pro-Leu-Gly-S-Leu-Leu-Gly-OC2H5

<400> 16
Pro Leu Gly Leu Leu Gly 
1               5       

<210> 17
<211> 4
<212> PRT
<213> Homo sapiens

<220> 
<223> Ac-Pro-Leu-Gly-S-CH2CH(CH3)CH2CH3

<400> 17
Pro Leu Gly Met 
1               

<210> 18
<211> 6
<212> PRT
<213> Homo sapiens

<220> 
<223> Ac-Pro-Leu-Gly-Leu-Leu-GIy-OC2H5

<400> 18
Pro Leu Gly Leu Leu Gly 
1               5       

<210> 19
<211> 6
<212> PRT
<213> Homo sapiens

<220> 
<223> Ac-Pro-Leu-Gly-Leu-Leu-Gly-OC2H5

<400> 19
Pro Leu Gly Leu Leu Gly 
1               5       

<210> 20
<211> 8
<212> PRT
<213> Homo sapiens

<220> 
<223> Mca-Lys-Pro-Leu-Gly-Leu-Lys (Dnp)-Ala-Arg-NH2

<400> 20
Lys Pro Leu Gly Leu Lys Ala Arg 
1               5               

<210> 21
<211> 6
<212> PRT
<213> Homo sapiens

<220> 
<223> (Gly-Pro-Hyp)5-Gly-Pro-Lys-Gly-Pro-Gln-Gly/Leu-Arg-Gly-Gln-Lys(Dn
      p)-Gly-Val-Arg-(Gly-Pro-Hyp)5-NH2

<400> 21
Gly Pro Leu Gln Arg Pro 
1               5       

<210> 22
<211> 25
<212> PRT
<213> Homo sapiens

<220> 
<223> (Gly-Pro-Hyp)5-Gly-Pro-Ser-Gly-Ala-Glu-Gly-Pro-Lys-Gly-Pro-Gln-Gl
      y/Leu-Arg-Gly-Gln-Lys(Dnp)-Gly-Val-Arg-(Gly-Pro-Hyp)5-NH2

<400> 22
Gly Pro Gly Pro Ser Gly Ala Glu Gly Pro Lys Gly Pro Gln Gly Leu 
1               5                   10                  15      
Arg Gly Gln Lys Gly Val Arg Gly Pro 
            20                  25  

<210> 23
<211> 27
<212> PRT
<213> Homo sapiens

<220> 
<223> (Gly-Pro-Hyp)4-Gly-Pro-Lys-Gly-Pro-Gln-Gly/Leu-Arg-Gly-Gln-Lys(Dn
      p)-Gly-Val-Arg-Gly-Leu-Hyp-Gly-Gln-Arg-Gly-Glu-Arg-(Gly-Pro-Hyp)4
      -NH2

<400> 23
Gly Pro Gly Pro Lys Gly Pro Gln Gly Leu Arg Gly Gln Lys Gly Val 
1               5                   10                  15      
Arg Gly Leu Gly Gln Arg Gly Glu Arg Gly Pro 
            20                  25          

<210> 24
<211> 12
<212> PRT
<213> Homo sapiens


<400> 24
Gly Thr Pro Gly Pro Gln Gly Ile Ala Gly Gln Arg 
1               5                   10          

<210> 25
<211> 13
<212> PRT
<213> Homo sapiens


<400> 25
Gly Thr Ala Gly Pro Pro Gly Thr Pro Gly Pro Gln Gly 
1               5                   10              

<210> 26
<211> 5
<212> PRT
<213> Homo sapiens

<220> 
<223> "The following bitter sequence can be combined with the in
      sequence 1 untill 25 mentioned linker peptides, taking the part
      left of the slash listed in the text thereof only:

<400> 26
Ile Ala Met Glu Lys 
1               5   

<210> 27
<211> 6
<212> PRT
<213> Homo sapiens

<220> 
<223> "The following bitter sequence can be combined with the in
      sequence 1 untill 25 mentioned linker peptides, taking the part
      left of the slash listed in the text thereof only:

<400> 27
Leu Leu Gly Ala Ile Leu 
1               5       

<210> 28
<211> 6
<212> PRT
<213> Homo sapiens

<220> 
<223> "The following bitter sequence can be combined with the in
      sequence 1 untill 25 mentioned linker peptides, taking the part
      left of the slash listed in the text thereof only:

<400> 28
Ile Ala Gly Ile Phe Pro 
1               5       

<210> 29
<211> 4
<212> PRT
<213> Homo sapiens

<220> 
<223> "The following bitter sequence can be combined with the in
      sequence 1 untill 25 mentioned linker peptides, taking the part
      left of the slash listed in the text thereof only:

<400> 29
Ile Ala Phe Pro 
1               

<210> 30
<211> 4
<212> PRT
<213> Homo sapiens

<220> 
<223> "The following bitter sequence can be combined with the in
      sequence 1 untill 25 mentioned linker peptides, taking the part
      left of the slash listed in the text thereof only:

<400> 30
Ile Ala Gly Ile 
1               

<210> 31
<211> 4
<212> PRT
<213> Homo sapiens

<220> 
<223> "The following bitter sequence can be combined with the in
      sequence 1 untill 25 mentioned linker peptides, taking the part
      left of the slash listed in the text thereof only:

<400> 31
Ile Phe Phe Pro 
1               

<210> 32
<211> 4
<212> PRT
<213> Homo sapiens

<220> 
<223> "The following bitter sequence can be combined with the in
      sequence 1 untill 25 mentioned linker peptides, taking the part
      left of the slash listed in the text thereof only:

<400> 32
Ile Phe Ile Phe 
1               

<210> 33
<211> 4
<212> PRT
<213> Homo sapiens

<220> 
<223> The following bitter sequence can be combined with the in
      sequence 1 untill 25 mentioned linker peptides, taking the part
      left of the slash listed in the text thereof only:

<400> 33
Ile Phe Val Leu 
1               

<210> 34
<211> 4
<212> PRT
<213> Homo sapiens

<220> 
<223> The following bitter sequence can be combined with the in
      sequence 1 untill 25 mentioned linker peptides, taking the part
      left of the slash listed in the text thereof only:

<400> 34
Ile Phe Trp Ile 
1               

<210> 35
<211> 4
<212> PRT
<213> Homo sapiens

<220> 
<223> The following bitter sequence can be combined with the in
      sequence 1 untill 25 mentioned linker peptides, taking the part
      left of the slash listed in the text thereof only:

<400> 35
Ile Phe Trp Tyr 
1               

<210> 36
<211> 6
<212> PRT
<213> Homo sapiens

<220> 
<223> Generally speaking, combinations of Tyr, Ile, Phe, Pro, Leu, Val 
      can be used for the bitter part sequences. "The following bitter 
      sequence can be combined with the in sequence 1 untill 25 mention
      ed linker peptides, taking the part left of the slash listed in t

<400> 36
Tyr Ile Phe Pro Leu Val 
1               5       

<210> 37
<211> 4
<212> PRT
<213> Homo sapiens

<220> 
<223> The following bitter sequence can be combined with the in
      sequence 1 untill 25 mentioned linker peptides, taking the part
      left of the slash listed in the text thereof only:

<400> 37
Ile Trp Gly Gln 
1               

<210> 38
<211> 4
<212> PRT
<213> Homo sapiens

<220> 
<223> The following bitter sequence can be combined with the in
      sequence 1 untill 25 mentioned linker peptides, taking the part
      left of the slash listed in the text thereof only:

<400> 38
Ile Trp Ile Phe 
1               

<210> 39
<211> 4
<212> PRT
<213> Homo sapiens

<220> 
<223> "The following bitter sequence can be combined with the in
      sequence 1 untill 25 mentioned linker peptides, taking the part
      left of the slash listed in the text thereof only:

<400> 39
Ile Trp Gly Pro 
1               

<210> 40
<211> 8
<212> PRT
<213> Homo sapiens

<220> 
<223> The following bitter sequence can be combined with the in
      sequence 1 untill 25 mentioned linker peptides, taking the part
      left of the slash listed in the text thereof only:

<400> 40
Ile Ala Gly Gln Ile Tyr Pro Ile 
1               5               

<210> 41
<211> 6
<212> PRT
<213> Homo sapiens

<220> 
<223> The following bitter sequence can be combined with the in
      sequence 1 untill 25 mentioned linker peptides, taking the part
      left of the slash listed in the text thereof only:

<400> 41
Ile Ser Pro Pro Pro Gly 
1               5       

<210> 42
<211> 7
<212> PRT
<213> Homo sapiens

<220> 
<223> The following bitter sequence can be combined with the in
      sequence 1 untill 25 mentioned linker peptides, taking the part
      left of the slash listed in the text thereof only:

<400> 42
Ile Ala Gly Gln Val Val Val 
1               5           

<210> 43
<211> 6
<212> PRT
<213> Homo sapiens

<220> 
<223> The following bitter sequence can be combined with the in
      sequence 1 untill 25 mentioned linker peptides, taking the part
      left of the slash listed in the text thereof only:

<400> 43
Gly Pro Phe Pro Val Ile 
1               5       

<210> 44
<211> 8
<212> PRT
<213> Homo sapiens

<220> 
<223> The following bitter sequence can be combined with the in
      sequence 1 untill 25 mentioned linker peptides, taking the part
      left of the slash listed in the text thereof only:

<400> 44
Phe Ala Leu Pro Glu Tyr Leu Lys 
1               5               

<210> 45
<211> 5
<212> PRT
<213> Homo sapiens

<220> 
<223> The following bitter sequence can be combined with the in
      sequence 1 untill 25 mentioned linker peptides, taking the part
      left of the slash listed in the text thereof only:

<400> 45
Leu Ile Tyr Pro Ile 
1               5   

<210> 46
<211> 4
<212> PRT
<213> Homo sapiens

<220> 
<223> Ethylation or acetylation just ahead of the cleavage site can be
      used to reduce the bitterness. E.g: OEtGlyProLeuGly

<400> 46
Gly Pro Leu Gly 
1               

<210> 47
<211> 4
<212> PRT
<213> Homo sapiens

<220> 
<223> Ethylation or acetylation just ahead of the cleavage site can be
      used to reduce the bitterness. E.g: CH3(O)CGlyProLeuGly

<400> 47
Gly Pro Leu Gly 
1               

