                         SEQUENCE LISTING

<110>  Merz Pharma GmbH & Co.KGaA
 
<120>  Means and methods for determining neurotoxin activity based on a 
       modified luciferase

<130>  MP10478PC

<150>  EP 12 158 450.2
<151>  2012-03-07

<150>  US 61/607,760
<151>  2012-03-07

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  685
<212>  PRT
<213>  artificial

<220>
<223>  luciferase fusion protein LuxAB

<400>  1

Met Lys Phe Gly Asn Phe Leu Leu Thr Tyr Gln Pro Pro Glu Leu Ser 
1               5                   10                  15      


Gln Thr Glu Val Met Lys Arg Leu Val Asn Leu Gly Lys Ala Ser Glu 
            20                  25                  30          


Gly Cys Gly Phe Asp Thr Val Trp Leu Leu Glu His His Phe Thr Glu 
        35                  40                  45              


Phe Gly Leu Leu Gly Asn Pro Tyr Val Ala Ala Ala His Leu Leu Gly 
    50                  55                  60                  


Ala Thr Glu Thr Leu Asn Val Gly Thr Ala Ala Ile Val Leu Pro Thr 
65                  70                  75                  80  


Ala His Pro Val Arg Gln Ala Glu Asp Val Asn Leu Leu Asp Gln Met 
                85                  90                  95      


Ser Lys Gly Arg Phe Arg Phe Gly Ile Cys Arg Gly Leu Tyr Asp Lys 
            100                 105                 110         


Asp Phe Arg Val Phe Gly Thr Asp Met Asp Asn Ser Arg Ala Leu Met 
        115                 120                 125             


Asp Cys Trp Tyr Asp Leu Met Lys Glu Gly Phe Asn Glu Gly Tyr Ile 
    130                 135                 140                 


Ala Ala Asp Asn Glu His Ile Lys Phe Pro Lys Ile Gln Leu Asn Pro 
145                 150                 155                 160 


Ser Ala Tyr Thr Gln Gly Gly Ala Pro Val Tyr Val Val Ala Glu Ser 
                165                 170                 175     


Ala Ser Thr Thr Glu Trp Ala Ala Glu Arg Gly Leu Pro Met Ile Leu 
            180                 185                 190         


Ser Trp Ile Ile Asn Thr His Glu Lys Lys Ala Gln Leu Asp Leu Tyr 
        195                 200                 205             


Asn Glu Val Ala Thr Glu His Gly Tyr Asp Val Thr Lys Ile Asp His 
    210                 215                 220                 


Cys Leu Ser Tyr Ile Thr Ser Val Asp His Asp Ser Asn Arg Ala Lys 
225                 230                 235                 240 


Asp Ile Cys Arg Asn Phe Leu Gly His Trp Tyr Asp Ser Tyr Val Asn 
                245                 250                 255     


Ala Thr Lys Ile Phe Asp Asp Ser Asp Gln Thr Lys Gly Tyr Asp Phe 
            260                 265                 270         


Asn Lys Gly Gln Trp Arg Asp Phe Val Leu Lys Gly His Lys Asp Thr 
        275                 280                 285             


Asn Arg Arg Ile Asp Tyr Ser Tyr Glu Ile Asn Pro Val Gly Thr Pro 
    290                 295                 300                 


Glu Glu Cys Ile Ala Ile Ile Gln Gln Asp Ile Asp Ala Thr Gly Ile 
305                 310                 315                 320 


Asp Asn Ile Cys Cys Gly Phe Glu Ala Asn Gly Ser Glu Glu Glu Ile 
                325                 330                 335     


Ile Ala Ser Met Lys Leu Phe Gln Ser Asp Val Met Pro Tyr Leu Lys 
            340                 345                 350         


Glu Lys Gln Tyr Leu Ile Phe Ser Gln Lys Glu Arg Asp Lys Lys Phe 
        355                 360                 365             


Gly Leu Phe Phe Leu Asn Phe Met Asn Ser Lys Arg Ser Ser Asp Gln 
    370                 375                 380                 


Val Ile Glu Glu Met Leu Asp Thr Ala His Tyr Val Asp Gln Leu Lys 
385                 390                 395                 400 


Phe Asp Thr Leu Ala Val Tyr Glu Asn His Phe Ser Asn Asn Gly Val 
                405                 410                 415     


Val Gly Ala Pro Leu Thr Val Ala Gly Phe Leu Leu Gly Met Thr Lys 
            420                 425                 430         


Asn Ala Lys Val Ala Ser Leu Asn His Val Ile Thr Thr His His Pro 
        435                 440                 445             


Val Arg Val Ala Glu Glu Ala Cys Leu Leu Asp Gln Met Ser Glu Gly 
    450                 455                 460                 


Arg Phe Ala Phe Gly Phe Ser Asp Cys Glu Lys Ser Ala Asp Met Arg 
465                 470                 475                 480 


Phe Phe Asn Arg Pro Thr Asp Ser Gln Phe Gln Leu Phe Ser Glu Cys 
                485                 490                 495     


His Lys Ile Ile Asn Asp Ala Phe Thr Thr Gly Tyr Cys His Pro Asn 
            500                 505                 510         


Asn Asp Phe Tyr Ser Phe Pro Lys Ile Ser Val Asn Pro His Ala Phe 
        515                 520                 525             


Thr Glu Gly Gly Pro Ala Gln Phe Val Asn Ala Thr Ser Lys Glu Val 
    530                 535                 540                 


Val Glu Trp Ala Ala Lys Leu Gly Leu Pro Leu Val Phe Arg Trp Asp 
545                 550                 555                 560 


Asp Ser Asn Ala Gln Arg Lys Glu Tyr Ala Gly Leu Tyr His Glu Val 
                565                 570                 575     


Ala Gln Ala His Gly Val Asp Val Ser Gln Val Arg His Lys Leu Thr 
            580                 585                 590         


Leu Leu Val Asn Gln Asn Val Asp Gly Glu Ala Ala Arg Ala Glu Ala 
        595                 600                 605             


Arg Val Tyr Leu Glu Glu Phe Val Arg Glu Ser Tyr Ser Asn Thr Asp 
    610                 615                 620                 


Phe Glu Gln Lys Met Gly Glu Leu Leu Ser Glu Asn Ala Ile Gly Thr 
625                 630                 635                 640 


Tyr Glu Glu Ser Thr Gln Ala Ala Arg Val Ala Ile Glu Cys Cys Gly 
                645                 650                 655     


Ala Ala Asp Leu Leu Met Ser Phe Glu Ser Met Glu Asp Lys Ala Gln 
            660                 665                 670         


Gln Arg Ala Val Ile Asp Val Val Asn Ala Asn Ile Val 
        675                 680                 685 


<210>  2
<211>  691
<212>  PRT
<213>  artificial

<220>
<223>  luciferase fusion protein LuxBA_1

<400>  2

Met Lys Phe Gly Leu Phe Phe Leu Asn Phe Met Asn Ser Lys Arg Ser 
1               5                   10                  15      


Ser Asp Gln Val Ile Glu Glu Met Leu Asp Thr Ala His Tyr Val Asp 
            20                  25                  30          


Gln Leu Lys Phe Asp Thr Leu Ala Val Tyr Glu Asn His Phe Ser Asn 
        35                  40                  45              


Asn Gly Val Val Gly Ala Pro Leu Thr Val Ala Gly Phe Leu Leu Gly 
    50                  55                  60                  


Met Thr Lys Asn Ala Lys Val Ala Ser Leu Asn His Val Ile Thr Thr 
65                  70                  75                  80  


His His Pro Val Arg Val Ala Glu Glu Ala Cys Leu Leu Asp Gln Met 
                85                  90                  95      


Ser Glu Gly Arg Phe Ala Phe Gly Phe Ser Asp Cys Glu Lys Ser Ala 
            100                 105                 110         


Asp Met Arg Phe Phe Asn Arg Pro Thr Asp Ser Gln Phe Gln Leu Phe 
        115                 120                 125             


Ser Glu Cys His Lys Ile Ile Asn Asp Ala Phe Thr Thr Gly Tyr Cys 
    130                 135                 140                 


His Pro Asn Asn Asp Phe Tyr Ser Phe Pro Lys Ile Ser Val Asn Pro 
145                 150                 155                 160 


His Ala Phe Thr Glu Gly Gly Pro Ala Gln Phe Val Asn Ala Thr Ser 
                165                 170                 175     


Lys Glu Val Val Glu Trp Ala Ala Lys Leu Gly Leu Pro Leu Val Phe 
            180                 185                 190         


Arg Trp Asp Asp Ser Asn Ala Gln Arg Lys Glu Tyr Ala Gly Leu Tyr 
        195                 200                 205             


His Glu Val Ala Gln Ala His Gly Val Asp Val Ser Gln Val Arg His 
    210                 215                 220                 


Lys Leu Thr Leu Leu Val Asn Gln Asn Val Asp Gly Glu Ala Ala Arg 
225                 230                 235                 240 


Ala Glu Ala Arg Val Tyr Leu Glu Glu Phe Val Arg Glu Ser Tyr Ser 
                245                 250                 255     


Asn Thr Asp Phe Glu Gln Lys Met Gly Glu Leu Leu Ser Glu Asn Ala 
            260                 265                 270         


Ile Gly Thr Tyr Glu Glu Ser Thr Gln Ala Ala Arg Val Ala Ile Glu 
        275                 280                 285             


Cys Cys Gly Ala Ala Asp Leu Leu Met Ser Phe Glu Ser Met Glu Asp 
    290                 295                 300                 


Lys Ala Gln Gln Arg Ala Val Ile Asp Val Val Ala Asn Ile Val Thr 
305                 310                 315                 320 


Arg Ile Asp Glu Ala Asn Gln Arg Ala Thr Lys Met Leu Gly Ser Gly 
                325                 330                 335     


Met Lys Phe Gly Asn Phe Leu Leu Thr Tyr Gln Pro Pro Glu Leu Ser 
            340                 345                 350         


Gln Thr Glu Val Met Lys Arg Leu Val Asn Leu Gly Lys Ala Ser Glu 
        355                 360                 365             


Gly Cys Gly Phe Asp Thr Val Trp Leu Leu Glu His His Phe Thr Glu 
    370                 375                 380                 


Phe Gly Leu Leu Gly Asn Pro Tyr Val Ala Ala Ala His Leu Leu Gly 
385                 390                 395                 400 


Ala Thr Glu Thr Leu Asn Val Gly Thr Ala Ala Ile Val Leu Pro Thr 
                405                 410                 415     


Ala His Pro Val Arg Gln Ala Glu Asp Val Asn Leu Leu Asp Gln Met 
            420                 425                 430         


Ser Lys Gly Arg Phe Arg Phe Gly Ile Cys Arg Gly Leu Tyr Asp Lys 
        435                 440                 445             


Asp Phe Arg Val Phe Gly Thr Asp Met Asp Asn Ser Arg Ala Leu Met 
    450                 455                 460                 


Asp Cys Trp Tyr Asp Leu Met Lys Glu Gly Phe Asn Glu Gly Tyr Ile 
465                 470                 475                 480 


Ala Ala Asp Asn Glu His Ile Lys Phe Pro Lys Ile Gln Leu Asn Pro 
                485                 490                 495     


Ser Ala Tyr Thr Gln Gly Gly Ala Pro Val Tyr Val Val Ala Glu Ser 
            500                 505                 510         


Ala Ser Thr Thr Glu Trp Ala Ala Glu Arg Gly Leu Pro Met Ile Leu 
        515                 520                 525             


Ser Trp Ile Ile Asn Thr His Glu Lys Lys Ala Gln Leu Asp Leu Tyr 
    530                 535                 540                 


Asn Glu Val Ala Thr Glu His Gly Tyr Asp Val Thr Lys Ile Asp His 
545                 550                 555                 560 


Cys Leu Ser Tyr Ile Thr Ser Val Asp His Asp Ser Asn Arg Ala Lys 
                565                 570                 575     


Asp Ile Cys Arg Asn Phe Leu Gly His Trp Tyr Asp Ser Tyr Val Asn 
            580                 585                 590         


Ala Thr Lys Ile Phe Asp Asp Ser Asp Gln Thr Lys Gly Tyr Asp Phe 
        595                 600                 605             


Asn Lys Gly Gln Trp Arg Asp Phe Val Leu Lys Gly His Lys Asp Thr 
    610                 615                 620                 


Asn Arg Arg Ile Asp Tyr Ser Tyr Glu Ile Asn Pro Val Gly Thr Pro 
625                 630                 635                 640 


Glu Glu Cys Ile Ala Ile Ile Gln Gln Asp Ile Asp Ala Thr Gly Ile 
                645                 650                 655     


Asp Asn Ile Cys Cys Gly Phe Glu Ala Asn Gly Ser Glu Glu Glu Ile 
            660                 665                 670         


Ile Ala Ser Met Lys Leu Phe Gln Ser Asp Val Met Pro Tyr Leu Lys 
        675                 680                 685             


Glu Lys Gln 
    690     


<210>  3
<211>  741
<212>  PRT
<213>  artificial

<220>
<223>  luciferase fusion protein LuxBA_3

<400>  3

Met Lys Phe Gly Leu Phe Phe Leu Asn Phe Met Asn Ser Lys Arg Ser 
1               5                   10                  15      


Ser Asp Gln Val Ile Glu Glu Met Leu Asp Thr Ala His Tyr Val Asp 
            20                  25                  30          


Gln Leu Lys Phe Asp Thr Leu Ala Val Tyr Glu Asn His Phe Ser Asn 
        35                  40                  45              


Asn Gly Val Val Gly Ala Pro Leu Thr Val Ala Gly Phe Leu Leu Gly 
    50                  55                  60                  


Met Thr Lys Asn Ala Lys Val Ala Ser Leu Asn His Val Ile Thr Thr 
65                  70                  75                  80  


His His Pro Val Arg Val Ala Glu Glu Ala Cys Leu Leu Asp Gln Met 
                85                  90                  95      


Ser Glu Gly Arg Phe Ala Phe Gly Phe Ser Asp Cys Glu Lys Ser Ala 
            100                 105                 110         


Asp Met Arg Phe Phe Asn Arg Pro Thr Asp Ser Gln Phe Gln Leu Phe 
        115                 120                 125             


Ser Glu Cys His Lys Ile Ile Asn Asp Ala Phe Thr Thr Gly Tyr Cys 
    130                 135                 140                 


His Pro Asn Asn Asp Phe Tyr Ser Phe Pro Lys Ile Ser Val Asn Pro 
145                 150                 155                 160 


His Ala Phe Thr Glu Gly Gly Pro Ala Gln Phe Val Asn Ala Thr Ser 
                165                 170                 175     


Lys Glu Val Val Glu Trp Ala Ala Lys Leu Gly Leu Pro Leu Val Phe 
            180                 185                 190         


Arg Trp Asp Asp Ser Asn Ala Gln Arg Lys Glu Tyr Ala Gly Leu Tyr 
        195                 200                 205             


His Glu Val Ala Gln Ala His Gly Val Asp Val Ser Gln Val Arg His 
    210                 215                 220                 


Lys Leu Thr Leu Leu Val Asn Gln Asn Val Asp Gly Glu Ala Ala Arg 
225                 230                 235                 240 


Ala Glu Ala Arg Val Tyr Leu Glu Glu Phe Val Arg Glu Ser Tyr Ser 
                245                 250                 255     


Asn Thr Asp Phe Glu Gln Lys Met Gly Glu Leu Leu Ser Glu Asn Ala 
            260                 265                 270         


Ile Gly Thr Tyr Glu Glu Ser Thr Gln Ala Ala Arg Val Ala Ile Glu 
        275                 280                 285             


Cys Cys Gly Ala Ala Asp Leu Leu Met Ser Phe Glu Ser Met Glu Asp 
    290                 295                 300                 


Lys Ala Gln Gln Arg Ala Val Ile Asp Val Val Arg Arg Val Thr Asp 
305                 310                 315                 320 


Ala Arg Glu Asn Glu Met Asp Glu Asn Leu Glu Gln Val Ser Gly Ile 
                325                 330                 335     


Ile Gly Asn Leu Arg His Met Ala Leu Asp Met Gly Asn Glu Ile Asp 
            340                 345                 350         


Thr Gln Asn Arg Gln Ile Asp Arg Ile Met Glu Lys Ala Asp Ser Asn 
        355                 360                 365             


Lys Thr Arg Ile Asp Glu Ala Asn Gln Arg Ala Thr Lys Met Leu Gly 
    370                 375                 380                 


Ser Gly Lys Lys Phe Gly Asn Phe Leu Leu Thr Tyr Gln Pro Pro Glu 
385                 390                 395                 400 


Leu Ser Gln Thr Glu Val Met Lys Arg Leu Val Asn Leu Gly Lys Ala 
                405                 410                 415     


Ser Glu Gly Cys Gly Phe Asp Thr Val Trp Leu Leu Glu His His Phe 
            420                 425                 430         


Thr Glu Phe Gly Leu Leu Gly Asn Pro Tyr Val Ala Ala Ala His Leu 
        435                 440                 445             


Leu Gly Ala Thr Glu Thr Leu Asn Val Gly Thr Ala Ala Ile Val Leu 
    450                 455                 460                 


Pro Thr Ala His Pro Val Arg Gln Ala Glu Asp Val Asn Leu Leu Asp 
465                 470                 475                 480 


Gln Met Ser Lys Gly Arg Phe Arg Phe Gly Ile Cys Arg Gly Leu Tyr 
                485                 490                 495     


Asp Lys Asp Phe Arg Val Phe Gly Thr Asp Met Asp Asn Ser Arg Ala 
            500                 505                 510         


Leu Met Asp Cys Trp Tyr Asp Leu Met Lys Glu Gly Phe Asn Glu Gly 
        515                 520                 525             


Tyr Ile Ala Ala Asp Asn Glu His Ile Lys Phe Pro Lys Ile Gln Leu 
    530                 535                 540                 


Asn Pro Ser Ala Tyr Thr Gln Gly Gly Ala Pro Val Tyr Val Val Ala 
545                 550                 555                 560 


Glu Ser Ala Ser Thr Thr Glu Trp Ala Ala Glu Arg Gly Leu Pro Met 
                565                 570                 575     


Ile Leu Ser Trp Ile Ile Asn Thr His Glu Lys Lys Ala Gln Leu Asp 
            580                 585                 590         


Leu Tyr Asn Glu Val Ala Thr Glu His Gly Tyr Asp Val Thr Lys Ile 
        595                 600                 605             


Asp His Cys Leu Ser Tyr Ile Thr Ser Val Asp His Asp Ser Asn Arg 
    610                 615                 620                 


Ala Lys Asp Ile Cys Arg Asn Phe Leu Gly His Trp Tyr Asp Ser Tyr 
625                 630                 635                 640 


Val Asn Ala Thr Lys Ile Phe Asp Asp Ser Asp Gln Thr Lys Gly Tyr 
                645                 650                 655     


Asp Phe Asn Lys Gly Gln Trp Arg Asp Phe Val Leu Lys Gly His Lys 
            660                 665                 670         


Asp Thr Asn Arg Arg Ile Asp Tyr Ser Tyr Glu Ile Asn Pro Val Gly 
        675                 680                 685             


Thr Pro Glu Glu Cys Ile Ala Ile Ile Gln Gln Asp Ile Asp Ala Thr 
    690                 695                 700                 


Gly Ile Asp Asn Ile Cys Cys Gly Phe Glu Ala Asn Gly Ser Glu Glu 
705                 710                 715                 720 


Glu Ile Ile Ala Ser Met Lys Leu Phe Gln Ser Asp Val Met Pro Tyr 
                725                 730                 735     


Leu Lys Glu Lys Gln 
            740     


<210>  4
<211>  319
<212>  PRT
<213>  Vibrio fischeri

<400>  4

Lys Phe Gly Leu Phe Phe Leu Asn Phe Met Asn Ser Lys Arg Ser Ser 
1               5                   10                  15      


Asp Gln Val Ile Glu Glu Met Leu Asp Thr Ala His Tyr Val Asp Gln 
            20                  25                  30          


Leu Lys Phe Asp Thr Leu Ala Val Tyr Glu Asn His Phe Ser Asn Asn 
        35                  40                  45              


Gly Val Val Gly Ala Pro Leu Thr Val Ala Gly Phe Leu Leu Gly Met 
    50                  55                  60                  


Thr Lys Asn Ala Lys Val Ala Ser Leu Asn His Val Ile Thr Thr His 
65                  70                  75                  80  


His Pro Val Arg Val Ala Glu Glu Ala Cys Leu Leu Asp Gln Met Ser 
                85                  90                  95      


Glu Gly Arg Phe Ala Phe Gly Phe Ser Asp Cys Glu Lys Ser Ala Asp 
            100                 105                 110         


Met Arg Phe Phe Asn Arg Pro Thr Asp Ser Gln Phe Gln Leu Phe Ser 
        115                 120                 125             


Glu Cys His Lys Ile Ile Asn Asp Ala Phe Thr Thr Gly Tyr Cys His 
    130                 135                 140                 


Pro Asn Asn Asp Phe Tyr Ser Phe Pro Lys Ile Ser Val Asn Pro His 
145                 150                 155                 160 


Ala Phe Thr Glu Gly Gly Pro Ala Gln Phe Val Asn Ala Thr Ser Lys 
                165                 170                 175     


Glu Val Val Glu Trp Ala Ala Lys Leu Gly Leu Pro Leu Val Phe Arg 
            180                 185                 190         


Trp Asp Asp Ser Asn Ala Gln Arg Lys Glu Tyr Ala Gly Leu Tyr His 
        195                 200                 205             


Glu Val Ala Gln Ala His Gly Val Asp Val Ser Gln Val Arg His Lys 
    210                 215                 220                 


Leu Thr Leu Leu Val Asn Gln Asn Val Asp Gly Glu Ala Ala Arg Ala 
225                 230                 235                 240 


Glu Ala Arg Val Tyr Leu Glu Glu Phe Val Arg Glu Ser Tyr Ser Asn 
                245                 250                 255     


Thr Asp Phe Glu Gln Lys Met Gly Glu Leu Leu Ser Glu Asn Ala Ile 
            260                 265                 270         


Gly Thr Tyr Glu Glu Ser Thr Gln Ala Ala Arg Val Ala Ile Glu Cys 
        275                 280                 285             


Cys Gly Ala Ala Asp Leu Leu Met Ser Phe Glu Ser Met Glu Asp Lys 
    290                 295                 300                 


Ala Gln Gln Arg Ala Val Ile Asp Val Val Asn Ala Asn Ile Val 
305                 310                 315                 


<210>  5
<211>  355
<212>  PRT
<213>  Vibrio fischeri

<400>  5

Met Lys Phe Gly Asn Phe Leu Leu Thr Tyr Gln Pro Pro Glu Leu Ser 
1               5                   10                  15      


Gln Thr Glu Val Met Lys Arg Leu Val Asn Leu Gly Lys Ala Ser Glu 
            20                  25                  30          


Gly Cys Gly Phe Asp Thr Val Trp Leu Leu Glu His His Phe Thr Glu 
        35                  40                  45              


Phe Gly Leu Leu Gly Asn Pro Tyr Val Ala Ala Ala His Leu Leu Gly 
    50                  55                  60                  


Ala Thr Glu Thr Leu Asn Val Gly Thr Ala Ala Ile Val Leu Pro Thr 
65                  70                  75                  80  


Ala His Pro Val Arg Gln Ala Glu Asp Val Asn Leu Leu Asp Gln Met 
                85                  90                  95      


Ser Lys Gly Arg Phe Arg Phe Gly Ile Cys Arg Gly Leu Tyr Asp Lys 
            100                 105                 110         


Asp Phe Arg Val Phe Gly Thr Asp Met Asp Asn Ser Arg Ala Leu Met 
        115                 120                 125             


Asp Cys Trp Tyr Asp Leu Met Lys Glu Gly Phe Asn Glu Gly Tyr Ile 
    130                 135                 140                 


Ala Ala Asp Asn Glu His Ile Lys Phe Pro Lys Ile Gln Leu Asn Pro 
145                 150                 155                 160 


Ser Ala Tyr Thr Gln Gly Gly Ala Pro Val Tyr Val Val Ala Glu Ser 
                165                 170                 175     


Ala Ser Thr Thr Glu Trp Ala Ala Glu Arg Gly Leu Pro Met Ile Leu 
            180                 185                 190         


Ser Trp Ile Ile Asn Thr His Glu Lys Lys Ala Gln Leu Asp Leu Tyr 
        195                 200                 205             


Asn Glu Val Ala Thr Glu His Gly Tyr Asp Val Thr Lys Ile Asp His 
    210                 215                 220                 


Cys Leu Ser Tyr Ile Thr Ser Val Asp His Asp Ser Asn Arg Ala Lys 
225                 230                 235                 240 


Asp Ile Cys Arg Asn Phe Leu Gly His Trp Tyr Asp Ser Tyr Val Asn 
                245                 250                 255     


Ala Thr Lys Ile Phe Asp Asp Ser Asp Gln Thr Lys Gly Tyr Asp Phe 
            260                 265                 270         


Asn Lys Gly Gln Trp Arg Asp Phe Val Leu Lys Gly His Lys Asp Thr 
        275                 280                 285             


Asn Arg Arg Ile Asp Tyr Ser Tyr Glu Ile Asn Pro Val Gly Thr Pro 
    290                 295                 300                 


Glu Glu Cys Ile Ala Ile Ile Gln Gln Asp Ile Asp Ala Thr Gly Ile 
305                 310                 315                 320 


Asp Asn Ile Cys Cys Gly Phe Glu Ala Asn Gly Ser Glu Glu Glu Ile 
                325                 330                 335     


Ile Ala Ser Met Lys Leu Phe Gln Ser Asp Val Met Pro Tyr Leu Lys 
            340                 345                 350         


Glu Lys Gln 
        355 


<210>  6
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  SNAP25 linker 1

<400>  6

Thr Arg Ile Asp Glu Ala Asn Gln Arg Ala Thr Lys Met Leu Gly Ser 
1               5                   10                  15      


Gly 
    


<210>  7
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  SNAP25 linker 2

<400>  7

Ile Asp Glu Ala Asn Gln Arg Ala Thr Lys Met Leu Gly 
1               5                   10              


<210>  8
<211>  72
<212>  PRT
<213>  artificial

<220>
<223>  SNAP25 linker 3

<400>  8

Arg Arg Val Thr Asp Ala Arg Glu Asn Glu Met Asp Glu Asn Leu Glu 
1               5                   10                  15      


Gln Val Ser Gly Ile Ile Gly Asn Leu Arg His Met Ala Leu Asp Met 
            20                  25                  30          


Gly Asn Glu Ile Asp Thr Gln Asn Arg Gln Ile Asp Arg Ile Met Glu 
        35                  40                  45              


Lys Ala Asp Ser Asn Lys Thr Arg Ile Asp Glu Ala Asn Gln Arg Ala 
    50                  55                  60                  


Thr Lys Met Leu Gly Ser Gly Lys 
65                  70          


<210>  9
<211>  5230
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  construct MRZ_LuxAB0; DNA vector comprising LuxAB0 sequence

<400>  9
ccatcgaatg gccagatgat taattcctaa tttttgttga cactctatca ttgatagagt       60

tattttacca ctccctatca gtgatagaga aaagtgaaat gaatagttcg acaaaaatct      120

agaaataatt ttgtttaact ttaagaagga gatatacaaa tgaagttcgg caacttcctg      180

ctgacctacc agccccctga gctgagccag accgaagtga tgaagaggct ggtgaacctg      240

ggcaaggcca gcgagggctg tggcttcgac accgtgtggc tgctggaaca ccacttcacc      300

gagttcggcc tgctgggcaa cccttacgtg gccgctgccc atctgctggg cgccaccgag      360

acactgaacg tgggcaccgc cgccattgtg ctgcctacag cccaccctgt gcggcaggcc      420

gaggacgtga acctgctgga ccagatgagc aagggcaggt tcagattcgg catctgcagg      480

ggcctgtacg acaaggactt cagggtgttc ggcaccgaca tggacaacag cagggctctg      540

atggactgtt ggtacgacct gatgaaggaa ggcttcaacg agggctacat tgccgccgac      600

aacgagcaca tcaagttccc caagatccag ctgaacccca gcgcctacac acagggcgga      660

gcccctgtgt acgtggtggc cgagagcgcc tctacaaccg agtgggccgc tgagaggggc      720

ctgcccatga tcctgagctg gatcatcaac acccacgaga agaaggccca gctggacctg      780

tacaacgagg tggccacaga gcacggctac gacgtgacca agatcgacca ctgcctgagc      840

tacatcacca gcgtggacca cgacagcaac agggccaagg acatctgcag gaactttctg      900

ggccattggt acgacagcta cgtgaacgcc accaagatct tcgacgacag cgaccagacc      960

aagggctacg acttcaacaa gggccagtgg agggacttcg tgctgaaggg ccacaaggac     1020

accaacaggc ggatcgacta cagctacgag atcaaccccg tgggcacccc cgaggaatgt     1080

atcgccatca tccagcagga catcgacgcc accggcatcg acaacatctg ctgcggcttc     1140

gaggccaacg gcagcgagga agagatcatt gccagcatga agctgttcca gagcgacgtg     1200

atgccctacc tgaaagagaa gcagtacctg atcttcagcc agaaagagag ggacaagaag     1260

ttcgggctgt tcttcctgaa cttcatgaac agcaagaggt ccagcgacca ggtgatcgag     1320

gaaatgctgg acaccgccca ctacgtggac cagctgaagt tcgacaccct ggccgtgtac     1380

gagaaccact tcagcaacaa cggcgtggtg ggagcccctc tgacagtggc cggcttcctg     1440

ctgggaatga ccaagaacgc caaggtggcc agcctgaacc acgtgatcac cacccaccat     1500

cctgtgcggg tggccgaaga ggcctgtctg ctggatcaga tgtccgaggg cagattcgcc     1560

ttcggcttca gcgactgcga gaagtccgcc gacatgcggt tcttcaacag gcccaccgac     1620

agccagttcc agctgttcag cgagtgccac aagatcatca acgacgcctt caccaccggc     1680

tactgccacc ccaacaacga cttctacagc ttccctaaga tctccgtgaa cccccacgcc     1740

tttacagagg gcggacccgc ccagttcgtg aacgctacca gcaaggaagt ggtggagtgg     1800

gctgccaagc tgggcctgcc cctggtgttc agatgggacg actccaacgc ccagaggaaa     1860

gagtacgccg gcctgtacca tgaagtggct caggctcacg gcgtggacgt gtcccaggtc     1920

cggcacaagc tgaccctgct ggtgaaccag aacgtggacg gcgaggccgc tagagccgag     1980

gccagggtgt acctggaaga gttcgtgcgg gagagctaca gcaacaccga cttcgagcag     2040

aagatgggcg agctgctgag cgagaacgcc atcggcacct acgaggaaag cacccaggcc     2100

gccagagtgg ccatcgagtg ctgtggagcc gccgacctgc tgatgagctt cgagagcatg     2160

gaagataagg cccagcagag ggccgtgatc gacgtggtga acgccaacat cgtgggtctc     2220

agcgcttgga gccacccgca gttcgaaaaa taataagctt gacctgtgaa gtgaaaaatg     2280

gcgcacattg tgcgacattt tttttgtctg ccgtttaccg ctactgcgtc acggatctcc     2340

acgcgccctg tagcggcgca ttaagcgcgg cgggtgtggt ggttacgcgc agcgtgaccg     2400

ctacacttgc cagcgcccta gcgcccgctc ctttcgcttt cttcccttcc tttctcgcca     2460

cgttcgccgg ctttccccgt caagctctaa atcgggggct ccctttaggg ttccgattta     2520

gtgctttacg gcacctcgac cccaaaaaac ttgattaggg tgatggttca cgtagtgggc     2580

catcgccctg atagacggtt tttcgccctt tgacgttgga gtccacgttc tttaatagtg     2640

gactcttgtt ccaaactgga acaacactca accctatctc ggtctattct tttgatttat     2700

aagggatttt gccgatttcg gcctattggt taaaaaatga gctgatttaa caaaaattta     2760

acgcgaattt taacaaaata ttaacgctta caatttcagg tggcactttt cggggaaatg     2820

tgcgcggaac ccctatttgt ttatttttct aaatacattc aaatatgtat ccgctcatga     2880

gacaataacc ctgataaatg cttcaataat attgaaaaag gaagagtatg agtattcaac     2940

atttccgtgt cgcccttatt cccttttttg cggcattttg ccttcctgtt tttgctcacc     3000

cagaaacgct ggtgaaagta aaagatgctg aagatcagtt gggtgcacga gtgggttaca     3060

tcgaactgga tctcaacagc ggtaagatcc ttgagagttt tcgccccgaa gaacgttttc     3120

caatgatgag cacttttaaa gttctgctat gtggcgcggt attatcccgt attgacgccg     3180

ggcaagagca actcggtcgc cgcatacact attctcagaa tgacttggtt gagtactcac     3240

cagtcacaga aaagcatctt acggatggca tgacagtaag agaattatgc agtgctgcca     3300

taaccatgag tgataacact gcggccaact tacttctgac aacgatcgga ggaccgaagg     3360

agctaaccgc ttttttgcac aacatggggg atcatgtaac tcgccttgat cgttgggaac     3420

cggagctgaa tgaagccata ccaaacgacg agcgtgacac cacgatgcct gtagcaatgg     3480

caacaacgtt gcgcaaacta ttaactggcg aactacttac tctagcttcc cggcaacaat     3540

tgatagactg gatggaggcg gataaagttg caggaccact tctgcgctcg gcccttccgg     3600

ctggctggtt tattgctgat aaatctggag ccggtgagcg tggctctcgc ggtatcattg     3660

cagcactggg gccagatggt aagccctccc gtatcgtagt tatctacacg acggggagtc     3720

aggcaactat ggatgaacga aatagacaga tcgctgagat aggtgcctca ctgattaagc     3780

attggtagga attaatgatg tctcgtttag ataaaagtaa agtgattaac agcgcattag     3840

agctgcttaa tgaggtcgga atcgaaggtt taacaacccg taaactcgcc cagaagctag     3900

gtgtagagca gcctacattg tattggcatg taaaaaataa gcgggctttg ctcgacgcct     3960

tagccattga gatgttagat aggcaccata ctcacttttg ccctttagaa ggggaaagct     4020

ggcaagattt tttacgtaat aacgctaaaa gttttagatg tgctttacta agtcatcgcg     4080

atggagcaaa agtacattta ggtacacggc ctacagaaaa acagtatgaa actctcgaaa     4140

atcaattagc ctttttatgc caacaaggtt tttcactaga gaatgcatta tatgcactca     4200

gcgcagtggg gcattttact ttaggttgcg tattggaaga tcaagagcat caagtcgcta     4260

aagaagaaag ggaaacacct actactgata gtatgccgcc attattacga caagctatcg     4320

aattatttga tcaccaaggt gcagagccag ccttcttatt cggccttgaa ttgatcatat     4380

gcggattaga aaaacaactt aaatgtgaaa gtgggtctta aaagcagcat aacctttttc     4440

cgtgatggta acttcactag tttaaaagga tctaggtgaa gatccttttt gataatctca     4500

tgaccaaaat cccttaacgt gagttttcgt tccactgagc gtcagacccc gtagaaaaga     4560

tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa     4620

aaccaccgct accagcggtg gtttgtttgc cggatcaaga gctaccaact ctttttccga     4680

aggtaactgg cttcagcaga gcgcagatac caaatactgt ccttctagtg tagccgtagt     4740

taggccacca cttcaagaac tctgtagcac cgcctacata cctcgctctg ctaatcctgt     4800

taccagtggc tgctgccagt ggcgataagt cgtgtcttac cgggttggac tcaagacgat     4860

agttaccgga taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca cagcccagct     4920

tggagcgaac gacctacacc gaactgagat acctacagcg tgagctatga gaaagcgcca     4980

cgcttcccga agggagaaag gcggacaggt atccggtaag cggcagggtc ggaacaggag     5040

agcgcacgag ggagcttcca gggggaaacg cctggtatct ttatagtcct gtcgggtttc     5100

gccacctctg acttgagcgt cgatttttgt gatgctcgtc aggggggcgg agcctatgga     5160

aaaacgccag caacgcggcc tttttacggt tcctggcctt ttgctggcct tttgctcaca     5220

tgacccgaca                                                            5230


<210>  10
<211>  5398
<212>  DNA
<213>  artificial sequences

<220>
<223>  construct MRZ_LuxBA3; DNA vector comprising LuxBA3 sequence

<400>  10
ccatcgaatg gccagatgat taattcctaa tttttgttga cactctatca ttgatagagt       60

tattttacca ctccctatca gtgatagaga aaagtgaaat gaatagttcg acaaaaatct      120

agaaataatt ttgtttaact ttaagaagga gatatacaaa tgaagttcgg cctgttcttc      180

ctgaacttca tgaacagcaa gaggtccagc gaccaggtga tcgaggaaat gctggacacc      240

gcccactacg tggaccagct gaagttcgac accctggccg tgtacgagaa ccacttcagc      300

aacaacggcg tggtgggagc ccctctgaca gtggccggct tcctgctggg catgaccaag      360

aacgccaagg tggccagcct gaaccacgtg atcaccaccc accatcctgt gcgggtggcc      420

gaggaagcct gcctgctgga ccagatgagc gagggcagat tcgccttcgg cttcagcgac      480

tgcgagaagt ccgccgacat gcggttcttc aacaggccca ccgacagcca gttccagctg      540

ttcagcgagt gccacaagat catcaacgac gccttcacca ccggctactg ccaccccaac      600

aacgacttct acagcttccc caagatcagc gtgaaccccc acgccttcac agaaggcggc      660

cctgcccagt tcgtgaacgc tacaagcaaa gaggtggtgg aatgggccgc taagctgggc      720

ctgcccctgg tgttcagatg ggacgacagc aacgcccaga ggaaagagta cgccggcctg      780

taccacgaag tggcccaggc tcatggcgtg gacgtgtccc aggtccggca caagctgacc      840

ctgctggtga accagaacgt ggacggcgag gccgctagag ccgaggctag ggtgtacctg      900

gaagagttcg tgcgggagag ctacagcaac accgacttcg agcagaagat gggcgagctg      960

ctgagcgaga acgccatcgg cacctacgag gaaagcaccc aggccgccag agtggccatc     1020

gagtgctgtg gagccgccga cctgctgatg agcttcgaga gcatggaaga taaggcccag     1080

cagagggccg tgatcgacgt ggtgcggaga gtgaccgacg cccgggagaa cgagatggac     1140

gagaacctgg aacaggtgtc cggcatcatc ggcaacctga ggcacatggc cctggacatg     1200

ggcaacgaga tcgacaccca gaacaggcag atcgacagga tcatggaaaa ggccgacagc     1260

aacaagacca ggatcgacga ggccaaccag agggccacca agatgctggg aagcggcaag     1320

aagttcggca acttcctgct gacctaccag ccccctgagc tgagccagac cgaagtgatg     1380

aagagactgg tgaacctggg caaggccagc gagggctgtg gcttcgacac cgtgtggctg     1440

ctggaacacc acttcaccga gttcggactg ctgggcaacc cttacgtggc cgctgcccat     1500

ctgctgggcg ccaccgagac actgaacgtg ggcaccgccg ccattgtgct gcctacagcc     1560

caccctgtgc ggcaggctga ggacgtgaac ctgctggatc agatgtccaa gggcaggttc     1620

agattcggca tctgcagggg cctgtacgac aaggacttca gggtgttcgg caccgacatg     1680

gacaacagca gggccctgat ggactgttgg tacgacctga tgaaggaagg cttcaacgag     1740

ggctacattg ccgccgacaa cgagcacatc aagttcccta agatccagct gaatcccagc     1800

gcctacacac agggcggagc ccctgtgtac gtggtggccg agagcgcctc tacaaccgag     1860

tgggctgccg agaggggcct gcccatgatc ctgagctgga tcatcaacac ccacgagaag     1920

aaggcccagc tggacctgta caatgaggtg gccaccgagc acggctacga cgtgaccaag     1980

atcgaccact gcctgagcta catcaccagc gtggaccacg actccaacag ggccaaggac     2040

atctgcagga actttctggg ccattggtac gacagctacg tgaacgctac caagatcttc     2100

gacgacagcg accagaccaa gggctacgac ttcaacaagg gacagtggag ggacttcgtg     2160

ctgaagggcc acaaggacac caacagacgg atcgactaca gctacgagat caaccccgtg     2220

ggcacacctg aggaatgtat cgccatcatc cagcaggaca tcgacgccac cggcatcgac     2280

aacatctgct gcggcttcga ggccaacggc agcgaggaag agatcattgc cagcatgaag     2340

ctgttccaga gcgacgtgat gccctacctg aaagagaagc agggtctcag cgcttggagc     2400

cacccgcagt tcgaaaaata ataagcttga cctgtgaagt gaaaaatggc gcacattgtg     2460

cgacattttt tttgtctgcc gtttaccgct actgcgtcac ggatctccac gcgccctgta     2520

gcggcgcatt aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca     2580

gcgccctagc gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct     2640

ttccccgtca agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc     2700

acctcgaccc caaaaaactt gattagggtg atggttcacg tagtgggcca tcgccctgat     2760

agacggtttt tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc     2820

aaactggaac aacactcaac cctatctcgg tctattcttt tgatttataa gggattttgc     2880

cgatttcggc ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaatttta     2940

acaaaatatt aacgcttaca atttcaggtg gcacttttcg gggaaatgtg cgcggaaccc     3000

ctatttgttt atttttctaa atacattcaa atatgtatcc gctcatgaga caataaccct     3060

gataaatgct tcaataatat tgaaaaagga agagtatgag tattcaacat ttccgtgtcg     3120

cccttattcc cttttttgcg gcattttgcc ttcctgtttt tgctcaccca gaaacgctgg     3180

tgaaagtaaa agatgctgaa gatcagttgg gtgcacgagt gggttacatc gaactggatc     3240

tcaacagcgg taagatcctt gagagttttc gccccgaaga acgttttcca atgatgagca     3300

cttttaaagt tctgctatgt ggcgcggtat tatcccgtat tgacgccggg caagagcaac     3360

tcggtcgccg catacactat tctcagaatg acttggttga gtactcacca gtcacagaaa     3420

agcatcttac ggatggcatg acagtaagag aattatgcag tgctgccata accatgagtg     3480

ataacactgc ggccaactta cttctgacaa cgatcggagg accgaaggag ctaaccgctt     3540

ttttgcacaa catgggggat catgtaactc gccttgatcg ttgggaaccg gagctgaatg     3600

aagccatacc aaacgacgag cgtgacacca cgatgcctgt agcaatggca acaacgttgc     3660

gcaaactatt aactggcgaa ctacttactc tagcttcccg gcaacaattg atagactgga     3720

tggaggcgga taaagttgca ggaccacttc tgcgctcggc ccttccggct ggctggttta     3780

ttgctgataa atctggagcc ggtgagcgtg gctctcgcgg tatcattgca gcactggggc     3840

cagatggtaa gccctcccgt atcgtagtta tctacacgac ggggagtcag gcaactatgg     3900

atgaacgaaa tagacagatc gctgagatag gtgcctcact gattaagcat tggtaggaat     3960

taatgatgtc tcgtttagat aaaagtaaag tgattaacag cgcattagag ctgcttaatg     4020

aggtcggaat cgaaggttta acaacccgta aactcgccca gaagctaggt gtagagcagc     4080

ctacattgta ttggcatgta aaaaataagc gggctttgct cgacgcctta gccattgaga     4140

tgttagatag gcaccatact cacttttgcc ctttagaagg ggaaagctgg caagattttt     4200

tacgtaataa cgctaaaagt tttagatgtg ctttactaag tcatcgcgat ggagcaaaag     4260

tacatttagg tacacggcct acagaaaaac agtatgaaac tctcgaaaat caattagcct     4320

ttttatgcca acaaggtttt tcactagaga atgcattata tgcactcagc gcagtggggc     4380

attttacttt aggttgcgta ttggaagatc aagagcatca agtcgctaaa gaagaaaggg     4440

aaacacctac tactgatagt atgccgccat tattacgaca agctatcgaa ttatttgatc     4500

accaaggtgc agagccagcc ttcttattcg gccttgaatt gatcatatgc ggattagaaa     4560

aacaacttaa atgtgaaagt gggtcttaaa agcagcataa cctttttccg tgatggtaac     4620

ttcactagtt taaaaggatc taggtgaaga tcctttttga taatctcatg accaaaatcc     4680

cttaacgtga gttttcgttc cactgagcgt cagaccccgt agaaaagatc aaaggatctt     4740

cttgagatcc tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa ccaccgctac     4800

cagcggtggt ttgtttgccg gatcaagagc taccaactct ttttccgaag gtaactggct     4860

tcagcagagc gcagatacca aatactgtcc ttctagtgta gccgtagtta ggccaccact     4920

tcaagaactc tgtagcaccg cctacatacc tcgctctgct aatcctgtta ccagtggctg     4980

ctgccagtgg cgataagtcg tgtcttaccg ggttggactc aagacgatag ttaccggata     5040

aggcgcagcg gtcgggctga acggggggtt cgtgcacaca gcccagcttg gagcgaacga     5100

cctacaccga actgagatac ctacagcgtg agctatgaga aagcgccacg cttcccgaag     5160

ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg     5220

agcttccagg gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc cacctctgac     5280

ttgagcgtcg atttttgtga tgctcgtcag gggggcggag cctatggaaa aacgccagca     5340

acgcggcctt tttacggttc ctggcctttt gctggccttt tgctcacatg acccgaca       5398


<210>  11
<211>  2262
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LuxBA3 with C-terminal Streptavidin-tag

<400>  11
atgaagttcg gcctgttctt cctgaacttc atgaacagca agaggtccag cgaccaggtg       60

atcgaggaaa tgctggacac cgcccactac gtggaccagc tgaagttcga caccctggcc      120

gtgtacgaga accacttcag caacaacggc gtggtgggag cccctctgac agtggccggc      180

ttcctgctgg gcatgaccaa gaacgccaag gtggccagcc tgaaccacgt gatcaccacc      240

caccatcctg tgcgggtggc cgaggaagcc tgcctgctgg accagatgag cgagggcaga      300

ttcgccttcg gcttcagcga ctgcgagaag tccgccgaca tgcggttctt caacaggccc      360

accgacagcc agttccagct gttcagcgag tgccacaaga tcatcaacga cgccttcacc      420

accggctact gccaccccaa caacgacttc tacagcttcc ccaagatcag cgtgaacccc      480

cacgccttca cagaaggcgg ccctgcccag ttcgtgaacg ctacaagcaa agaggtggtg      540

gaatgggccg ctaagctggg cctgcccctg gtgttcagat gggacgacag caacgcccag      600

aggaaagagt acgccggcct gtaccacgaa gtggcccagg ctcatggcgt ggacgtgtcc      660

caggtccggc acaagctgac cctgctggtg aaccagaacg tggacggcga ggccgctaga      720

gccgaggcta gggtgtacct ggaagagttc gtgcgggaga gctacagcaa caccgacttc      780

gagcagaaga tgggcgagct gctgagcgag aacgccatcg gcacctacga ggaaagcacc      840

caggccgcca gagtggccat cgagtgctgt ggagccgccg acctgctgat gagcttcgag      900

agcatggaag ataaggccca gcagagggcc gtgatcgacg tggtgcggag agtgaccgac      960

gcccgggaga acgagatgga cgagaacctg gaacaggtgt ccggcatcat cggcaacctg     1020

aggcacatgg ccctggacat gggcaacgag atcgacaccc agaacaggca gatcgacagg     1080

atcatggaaa aggccgacag caacaagacc aggatcgacg aggccaacca gagggccacc     1140

aagatgctgg gaagcggcaa gaagttcggc aacttcctgc tgacctacca gccccctgag     1200

ctgagccaga ccgaagtgat gaagagactg gtgaacctgg gcaaggccag cgagggctgt     1260

ggcttcgaca ccgtgtggct gctggaacac cacttcaccg agttcggact gctgggcaac     1320

ccttacgtgg ccgctgccca tctgctgggc gccaccgaga cactgaacgt gggcaccgcc     1380

gccattgtgc tgcctacagc ccaccctgtg cggcaggctg aggacgtgaa cctgctggat     1440

cagatgtcca agggcaggtt cagattcggc atctgcaggg gcctgtacga caaggacttc     1500

agggtgttcg gcaccgacat ggacaacagc agggccctga tggactgttg gtacgacctg     1560

atgaaggaag gcttcaacga gggctacatt gccgccgaca acgagcacat caagttccct     1620

aagatccagc tgaatcccag cgcctacaca cagggcggag cccctgtgta cgtggtggcc     1680

gagagcgcct ctacaaccga gtgggctgcc gagaggggcc tgcccatgat cctgagctgg     1740

atcatcaaca cccacgagaa gaaggcccag ctggacctgt acaatgaggt ggccaccgag     1800

cacggctacg acgtgaccaa gatcgaccac tgcctgagct acatcaccag cgtggaccac     1860

gactccaaca gggccaagga catctgcagg aactttctgg gccattggta cgacagctac     1920

gtgaacgcta ccaagatctt cgacgacagc gaccagacca agggctacga cttcaacaag     1980

ggacagtgga gggacttcgt gctgaagggc cacaaggaca ccaacagacg gatcgactac     2040

agctacgaga tcaaccccgt gggcacacct gaggaatgta tcgccatcat ccagcaggac     2100

atcgacgcca ccggcatcga caacatctgc tgcggcttcg aggccaacgg cagcgaggaa     2160

gagatcattg ccagcatgaa gctgttccag agcgacgtga tgccctacct gaaagagaag     2220

cagggtctca gcgcttggag ccacccgcag ttcgaaaaat aa                        2262


<210>  12
<211>  2937
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LuxBA3 with N-terminal glutathione-S-transferase and C-terminal 
       Streptavidin-tag

<400>  12
atgtccccta tactaggtta ttggaaaatt aagggccttg tgcaacccac tcgacttctt       60

ttggaatatc ttgaagaaaa atatgaagag catttgtatg agcgcgatga aggtgataaa      120

tggcgaaaca aaaagtttga attgggtttg gagtttccca atcttcctta ttatattgat      180

ggtgatgtta aattaacaca gtctatggcc atcatacgtt atatagctga caagcacaac      240

atgttgggtg gttgtccaaa agagcgtgca gagatttcaa tgcttgaagg agcggttttg      300

gatattagat acggtgtttc gagaattgca tatagtaaag actttgaaac tctcaaagtt      360

gattttctta gcaagctacc tgaaatgctg aaaatgttcg aagatcgttt atgtcataaa      420

acatatttaa atggtgatca tgtaacccat cctgacttca tgttgtatga cgctcttgat      480

gttgttttat acatggaccc aatgtgcctg gatgcgttcc caaaattagt ttgttttaaa      540

aaacgtattg aagctatccc acaaattgat aagtacttga aatccagcaa gtatatagca      600

tggcctttgc agggctggca agccacgttt ggtggtggcg accatcctcc aaaatcggat      660

ctgatcgaag gtcggatgaa gttcggcctg ttcttcctga acttcatgaa cagcaagagg      720

tccagcgacc aggtgatcga ggaaatgctg gacaccgccc actacgtgga ccagctgaag      780

ttcgacaccc tggccgtgta cgagaaccac ttcagcaaca acggcgtggt gggagcccct      840

ctgacagtgg ccggcttcct gctgggcatg accaagaacg ccaaggtggc cagcctgaac      900

cacgtgatca ccacccacca tcctgtgcgg gtggccgagg aagcctgcct gctggaccag      960

atgagcgagg gcagattcgc cttcggcttc agcgactgcg agaagtccgc cgacatgcgg     1020

ttcttcaaca ggcccaccga cagccagttc cagctgttca gcgagtgcca caagatcatc     1080

aacgacgcct tcaccaccgg ctactgccac cccaacaacg acttctacag cttccccaag     1140

atcagcgtga acccccacgc cttcacagaa ggcggccctg cccagttcgt gaacgctaca     1200

agcaaagagg tggtggaatg ggccgctaag ctgggcctgc ccctggtgtt cagatgggac     1260

gacagcaacg cccagaggaa agagtacgcc ggcctgtacc acgaagtggc ccaggctcat     1320

ggcgtggacg tgtcccaggt ccggcacaag ctgaccctgc tggtgaacca gaacgtggac     1380

ggcgaggccg ctagagccga ggctagggtg tacctggaag agttcgtgcg ggagagctac     1440

agcaacaccg acttcgagca gaagatgggc gagctgctga gcgagaacgc catcggcacc     1500

tacgaggaaa gcacccaggc cgccagagtg gccatcgagt gctgtggagc cgccgacctg     1560

ctgatgagct tcgagagcat ggaagataag gcccagcaga gggccgtgat cgacgtggtg     1620

cggagagtga ccgacgcccg ggagaacgag atggacgaga acctggaaca ggtgtccggc     1680

atcatcggca acctgaggca catggccctg gacatgggca acgagatcga cacccagaac     1740

aggcagatcg acaggatcat ggaaaaggcc gacagcaaca agaccaggat cgacgaggcc     1800

aaccagaggg ccaccaagat gctgggaagc ggcaagaagt tcggcaactt cctgctgacc     1860

taccagcccc ctgagctgag ccagaccgaa gtgatgaaga gactggtgaa cctgggcaag     1920

gccagcgagg gctgtggctt cgacaccgtg tggctgctgg aacaccactt caccgagttc     1980

ggactgctgg gcaaccctta cgtggccgct gcccatctgc tgggcgccac cgagacactg     2040

aacgtgggca ccgccgccat tgtgctgcct acagcccacc ctgtgcggca ggctgaggac     2100

gtgaacctgc tggatcagat gtccaagggc aggttcagat tcggcatctg caggggcctg     2160

tacgacaagg acttcagggt gttcggcacc gacatggaca acagcagggc cctgatggac     2220

tgttggtacg acctgatgaa ggaaggcttc aacgagggct acattgccgc cgacaacgag     2280

cacatcaagt tccctaagat ccagctgaat cccagcgcct acacacaggg cggagcccct     2340

gtgtacgtgg tggccgagag cgcctctaca accgagtggg ctgccgagag gggcctgccc     2400

atgatcctga gctggatcat caacacccac gagaagaagg cccagctgga cctgtacaat     2460

gaggtggcca ccgagcacgg ctacgacgtg accaagatcg accactgcct gagctacatc     2520

accagcgtgg accacgactc caacagggcc aaggacatct gcaggaactt tctgggccat     2580

tggtacgaca gctacgtgaa cgctaccaag atcttcgacg acagcgacca gaccaagggc     2640

tacgacttca acaagggaca gtggagggac ttcgtgctga agggccacaa ggacaccaac     2700

agacggatcg actacagcta cgagatcaac cccgtgggca cacctgagga atgtatcgcc     2760

atcatccagc aggacatcga cgccaccggc atcgacaaca tctgctgcgg cttcgaggcc     2820

aacggcagcg aggaagagat cattgccagc atgaagctgt tccagagcga cgtgatgccc     2880

tacctgaaag agaagcaggg tctcagcgct tggagccacc cgcagttcga aaaataa        2937


<210>  13
<211>  2307
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LuxBA3 with N-terminal 9xHistidin and C-terminal Streptavidin-tag

<400>  13
atgggccatc atcatcatca tcaccaccat cacatcgaag gtcggatgaa gttcggcctg       60

ttcttcctga acttcatgaa cagcaagagg tccagcgacc aggtgatcga ggaaatgctg      120

gacaccgccc actacgtgga ccagctgaag ttcgacaccc tggccgtgta cgagaaccac      180

ttcagcaaca acggcgtggt gggagcccct ctgacagtgg ccggcttcct gctgggcatg      240

accaagaacg ccaaggtggc cagcctgaac cacgtgatca ccacccacca tcctgtgcgg      300

gtggccgagg aagcctgcct gctggaccag atgagcgagg gcagattcgc cttcggcttc      360

agcgactgcg agaagtccgc cgacatgcgg ttcttcaaca ggcccaccga cagccagttc      420

cagctgttca gcgagtgcca caagatcatc aacgacgcct tcaccaccgg ctactgccac      480

cccaacaacg acttctacag cttccccaag atcagcgtga acccccacgc cttcacagaa      540

ggcggccctg cccagttcgt gaacgctaca agcaaagagg tggtggaatg ggccgctaag      600

ctgggcctgc ccctggtgtt cagatgggac gacagcaacg cccagaggaa agagtacgcc      660

ggcctgtacc acgaagtggc ccaggctcat ggcgtggacg tgtcccaggt ccggcacaag      720

ctgaccctgc tggtgaacca gaacgtggac ggcgaggccg ctagagccga ggctagggtg      780

tacctggaag agttcgtgcg ggagagctac agcaacaccg acttcgagca gaagatgggc      840

gagctgctga gcgagaacgc catcggcacc tacgaggaaa gcacccaggc cgccagagtg      900

gccatcgagt gctgtggagc cgccgacctg ctgatgagct tcgagagcat ggaagataag      960

gcccagcaga gggccgtgat cgacgtggtg cggagagtga ccgacgcccg ggagaacgag     1020

atggacgaga acctggaaca ggtgtccggc atcatcggca acctgaggca catggccctg     1080

gacatgggca acgagatcga cacccagaac aggcagatcg acaggatcat ggaaaaggcc     1140

gacagcaaca agaccaggat cgacgaggcc aaccagaggg ccaccaagat gctgggaagc     1200

ggcaagaagt tcggcaactt cctgctgacc taccagcccc ctgagctgag ccagaccgaa     1260

gtgatgaaga gactggtgaa cctgggcaag gccagcgagg gctgtggctt cgacaccgtg     1320

tggctgctgg aacaccactt caccgagttc ggactgctgg gcaaccctta cgtggccgct     1380

gcccatctgc tgggcgccac cgagacactg aacgtgggca ccgccgccat tgtgctgcct     1440

acagcccacc ctgtgcggca ggctgaggac gtgaacctgc tggatcagat gtccaagggc     1500

aggttcagat tcggcatctg caggggcctg tacgacaagg acttcagggt gttcggcacc     1560

gacatggaca acagcagggc cctgatggac tgttggtacg acctgatgaa ggaaggcttc     1620

aacgagggct acattgccgc cgacaacgag cacatcaagt tccctaagat ccagctgaat     1680

cccagcgcct acacacaggg cggagcccct gtgtacgtgg tggccgagag cgcctctaca     1740

accgagtggg ctgccgagag gggcctgccc atgatcctga gctggatcat caacacccac     1800

gagaagaagg cccagctgga cctgtacaat gaggtggcca ccgagcacgg ctacgacgtg     1860

accaagatcg accactgcct gagctacatc accagcgtgg accacgactc caacagggcc     1920

aaggacatct gcaggaactt tctgggccat tggtacgaca gctacgtgaa cgctaccaag     1980

atcttcgacg acagcgacca gaccaagggc tacgacttca acaagggaca gtggagggac     2040

ttcgtgctga agggccacaa ggacaccaac agacggatcg actacagcta cgagatcaac     2100

cccgtgggca cacctgagga atgtatcgcc atcatccagc aggacatcga cgccaccggc     2160

atcgacaaca tctgctgcgg cttcgaggcc aacggcagcg aggaagagat cattgccagc     2220

atgaagctgt tccagagcga cgtgatgccc tacctgaaag agaagcaggg tctcagcgct     2280

tggagccacc cgcagttcga aaaataa                                         2307


<210>  14
<211>  7555
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ligation of LuxBA3 into pTZ_E47 vector

<400>  14
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg       60

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc      120

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg      180

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc      240

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt      300

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc      360

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta      420

acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt      480

tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta      540

tccgctcatg aattaattct tagaaaaact catcgagcat caaatgaaac tgcaatttat      600

tcatatcagg attatcaata ccatattttt gaaaaagccg tttctgtaat gaaggagaaa      660

actcaccgag gcagttccat aggatggcaa gatcctggta tcggtctgcg attccgactc      720

gtccaacatc aatacaacct attaatttcc cctcgtcaaa aataaggtta tcaagtgaga      780

aatcaccatg agtgacgact gaatccggtg agaatggcaa aagtttatgc atttctttcc      840

agacttgttc aacaggccag ccattacgct cgtcatcaaa atcactcgca tcaaccaaac      900

cgttattcat tcgtgattgc gcctgagcga gacgaaatac gcgatcgctg ttaaaaggac      960

aattacaaac aggaatcgaa tgcaaccggc gcaggaacac tgccagcgca tcaacaatat     1020

tttcacctga atcaggatat tcttctaata cctggaatgc tgttttcccg gggatcgcag     1080

tggtgagtaa ccatgcatca tcaggagtac ggataaaatg cttgatggtc ggaagaggca     1140

taaattccgt cagccagttt agtctgacca tctcatctgt aacatcattg gcaacgctac     1200

ctttgccatg tttcagaaac aactctggcg catcgggctt cccatacaat cgatagattg     1260

tcgcacctga ttgcccgaca ttatcgcgag cccatttata cccatataaa tcagcatcca     1320

tgttggaatt taatcgcggc ctagagcaag acgtttcccg ttgaatatgg ctcataacac     1380

cccttgtatt actgtttatg taagcagaca gttttattgt tcatgaccaa aatcccttaa     1440

cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga     1500

gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg     1560

gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc     1620

agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag     1680

aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc     1740

agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg     1800

cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac     1860

accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga     1920

aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt     1980

ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag     2040

cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg     2100

gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta     2160

tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc     2220

agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cctgatgcgg     2280

tattttctcc ttacgcatct gtgcggtatt tcacaccgca tatatggtgc actctcagta     2340

caatctgctc tgatgccgca tagttaagcc agtatacact ccgctatcgc tacgtgactg     2400

ggtcatggct gcgccccgac acccgccaac acccgctgac gcgccctgac gggcttgtct     2460

gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca tgtgtcagag     2520

gttttcaccg tcatcaccga aacgcgcgag gcagctgcgg taaagctcat cagcgtggtc     2580

gtgaagcgat tcacagatgt ctgcctgttc atccgcgtcc agctcgttga gtttctccag     2640

aagcgttaat gtctggcttc tgataaagcg ggccatgtta agggcggttt tttcctgttt     2700

ggtcactgat gcctccgtgt aagggggatt tctgttcatg ggggtaatga taccgatgaa     2760

acgagagagg atgctcacga tacgggttac tgatgatgaa catgcccggt tactggaacg     2820

ttgtgagggt aaacaactgg cggtatggat gcggcgggac cagagaaaaa tcactcaggg     2880

tcaatgccag cgcttcgtta atacagatgt aggtgttcca cagggtagcc agcagcatcc     2940

tgcgatgcag atccggaaca taatggtgca gggcgctgac ttccgcgttt ccagacttta     3000

cgaaacacgg aaaccgaaga ccattcatgt tgttgctcag gtcgcagacg ttttgcagca     3060

gcagtcgctt cacgttcgct cgcgtatcgg tgattcattc tgctaaccag taaggcaacc     3120

ccgccagcct agccgggtcc tcaacgacag gagcacgatc atgcgcaccc gtggggccgc     3180

catgccggcg ataatggcct gcttctcgcc gaaacgtttg gtggcgggac cagtgacgaa     3240

ggcttgagcg agggcgtgca agattccgaa taccgcaagc gacaggccga tcatcgtcgc     3300

gctccagcga aagcggtcct cgccgaaaat gacccagagc gctgccggca cctgtcctac     3360

gagttgcatg ataaagaaga cagtcataag tgcggcgacg atagtcatgc cccgcgccca     3420

ccggaaggag ctgactgggt tgaaggctct caagggcatc ggtcgagatc ccggtgccta     3480

atgagtgagc taacttacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa     3540

cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat     3600

tgggcgccag ggtggttttt cttttcacca gtgagacggg caacagctga ttgcccttca     3660

ccgcctggcc ctgagagagt tgcagcaagc ggtccacgct ggtttgcccc agcaggcgaa     3720

aatcctgttt gatggtggtt aacggcggga tataacatga gctgtcttcg gtatcgtcgt     3780

atcccactac cgagatatcc gcaccaacgc gcagcccgga ctcggtaatg gcgcgcattg     3840

cgcccagcgc catctgatcg ttggcaacca gcatcgcagt gggaacgatg ccctcattca     3900

gcatttgcat ggtttgttga aaaccggaca tggcactcca gtcgccttcc cgttccgcta     3960

tcggctgaat ttgattgcga gtgagatatt tatgccagcc agccagacgc agacgcgccg     4020

agacagaact taatgggccc gctaacagcg cgatttgctg gtgacccaat gcgaccagat     4080

gctccacgcc cagtcgcgta ccgtcttcat gggagaaaat aatactgttg atgggtgtct     4140

ggtcagagac atcaagaaat aacgccggaa cattagtgca ggcagcttcc acagcaatgg     4200

catcctggtc atccagcgga tagttaatga tcagcccact gacgcgttgc gcgagaagat     4260

tgtgcaccgc cgctttacag gcttcgacgc cgcttcgttc taccatcgac accaccacgc     4320

tggcacccag ttgatcggcg cgagatttaa tcgccgcgac aatttgcgac ggcgcgtgca     4380

gggccagact ggaggtggca acgccaatca gcaacgactg tttgcccgcc agttgttgtg     4440

ccacgcggtt gggaatgtaa ttcagctccg ccatcgccgc ttccactttt tcccgcgttt     4500

tcgcagaaac gtggctggcc tggttcacca cgcgggaaac ggtctgataa gagacaccgg     4560

catactctgc gacatcgtat aacgttactg gtttcacatt caccaccctg aattgactct     4620

cttccgggcg ctatcatgcc ataccgcgaa aggttttgcg ccattcgatg gtgtccggga     4680

tctcgacgct ctcccttatg cgactcctgc attaggaagc agcccagtag taggttgagg     4740

ccgttgagca ccgccgccgc aaggaatggt gcatgcaagg agatggcgcc caacagtccc     4800

ccggccacgg ggcctgccac catacccacg ccgaaacaag cgctcatgag cccgaagtgg     4860

cgagcccgat cttccccatc ggtgatgtcg gcgatatagg cgccagcaac cgcacctgtg     4920

gcgccggtga tgccggccac gatgcgtccg gcgtagagga tcgagatctc gatcccgcga     4980

aattaatacg actcactata ggggaattgt gagcggataa caattcccct ctagaaataa     5040

ttttgtttaa ctttaagaag gagatatacc atgggccatc atcatcatca tcaccaccat     5100

cacatcgaag gtcggatgaa gttcggcctg ttcttcctga acttcatgaa cagcaagagg     5160

tccagcgacc aggtgatcga ggaaatgctg gacaccgccc actacgtgga ccagctgaag     5220

ttcgacaccc tggccgtgta cgagaaccac ttcagcaaca acggcgtggt gggagcccct     5280

ctgacagtgg ccggcttcct gctgggcatg accaagaacg ccaaggtggc cagcctgaac     5340

cacgtgatca ccacccacca tcctgtgcgg gtggccgagg aagcctgcct gctggaccag     5400

atgagcgagg gcagattcgc cttcggcttc agcgactgcg agaagtccgc cgacatgcgg     5460

ttcttcaaca ggcccaccga cagccagttc cagctgttca gcgagtgcca caagatcatc     5520

aacgacgcct tcaccaccgg ctactgccac cccaacaacg acttctacag cttccccaag     5580

atcagcgtga acccccacgc cttcacagaa ggcggccctg cccagttcgt gaacgctaca     5640

agcaaagagg tggtggaatg ggccgctaag ctgggcctgc ccctggtgtt cagatgggac     5700

gacagcaacg cccagaggaa agagtacgcc ggcctgtacc acgaagtggc ccaggctcat     5760

ggcgtggacg tgtcccaggt ccggcacaag ctgaccctgc tggtgaacca gaacgtggac     5820

ggcgaggccg ctagagccga ggctagggtg tacctggaag agttcgtgcg ggagagctac     5880

agcaacaccg acttcgagca gaagatgggc gagctgctga gcgagaacgc catcggcacc     5940

tacgaggaaa gcacccaggc cgccagagtg gccatcgagt gctgtggagc cgccgacctg     6000

ctgatgagct tcgagagcat ggaagataag gcccagcaga gggccgtgat cgacgtggtg     6060

cggagagtga ccgacgcccg ggagaacgag atggacgaga acctggaaca ggtgtccggc     6120

atcatcggca acctgaggca catggccctg gacatgggca acgagatcga cacccagaac     6180

aggcagatcg acaggatcat ggaaaaggcc gacagcaaca agaccaggat cgacgaggcc     6240

aaccagaggg ccaccaagat gctgggaagc ggcaagaagt tcggcaactt cctgctgacc     6300

taccagcccc ctgagctgag ccagaccgaa gtgatgaaga gactggtgaa cctgggcaag     6360

gccagcgagg gctgtggctt cgacaccgtg tggctgctgg aacaccactt caccgagttc     6420

ggactgctgg gcaaccctta cgtggccgct gcccatctgc tgggcgccac cgagacactg     6480

aacgtgggca ccgccgccat tgtgctgcct acagcccacc ctgtgcggca ggctgaggac     6540

gtgaacctgc tggatcagat gtccaagggc aggttcagat tcggcatctg caggggcctg     6600

tacgacaagg acttcagggt gttcggcacc gacatggaca acagcagggc cctgatggac     6660

tgttggtacg acctgatgaa ggaaggcttc aacgagggct acattgccgc cgacaacgag     6720

cacatcaagt tccctaagat ccagctgaat cccagcgcct acacacaggg cggagcccct     6780

gtgtacgtgg tggccgagag cgcctctaca accgagtggg ctgccgagag gggcctgccc     6840

atgatcctga gctggatcat caacacccac gagaagaagg cccagctgga cctgtacaat     6900

gaggtggcca ccgagcacgg ctacgacgtg accaagatcg accactgcct gagctacatc     6960

accagcgtgg accacgactc caacagggcc aaggacatct gcaggaactt tctgggccat     7020

tggtacgaca gctacgtgaa cgctaccaag atcttcgacg acagcgacca gaccaagggc     7080

tacgacttca acaagggaca gtggagggac ttcgtgctga agggccacaa ggacaccaac     7140

agacggatcg actacagcta cgagatcaac cccgtgggca cacctgagga atgtatcgcc     7200

atcatccagc aggacatcga cgccaccggc atcgacaaca tctgctgcgg cttcgaggcc     7260

aacggcagcg aggaagagat cattgccagc atgaagctgt tccagagcga cgtgatgccc     7320

tacctgaaag agaagcaggg tctcagcgct tggagccacc cgcagttcga aaaataatag     7380

gcgcgccgga tcctcgagca ccaccaccac caccactgag atccggctgc taacaaagcc     7440

cgaaaggaag ctgagttggc tgctgccacc gctgagcaat aactagcata accccttggg     7500

gcctctaaac gggtcttgag gggttttttg ctgaaaggag gaactatatc cggat          7555


