SEQUENCE LISTING

<110>   NOVARTIS AG

<120>   ADJUVANTED FORMULATIONS OF STREPTOCOCCUS PNEUMONIAE ANTIGENS

<130>   PAT055007-WO-PCT

<140>   PCT/__2013/______
<141>   2013-03-??

<150>   US 61/607,987
<151>   2012-03-07

<150>   US 61/608,013
<151>   2012-03-07

<160>   340

<170>   SeqWin99, version 1.02

<210>   1
<211>   1312
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   1
Met Lys His Glu Lys Gln Gln Arg Phe Ser Ile Arg Lys Tyr Ala Val 
1               5                   10                  15      

Gly Ala Ala Ser Val Leu Ile Gly Phe Ala Phe Gln Ala Gln Thr Val 
            20                  25                  30          

Ala Ala Asp Gly Val Thr Pro Thr Thr Thr Glu Asn Gln Pro Thr Ile 
        35                  40                  45              

His Thr Val Ser Asp Ser Pro Gln Ser Ser Glu Asn Arg Thr Glu Glu 
    50                  55                  60                  

Thr Pro Lys Ala Glu Leu Gln Pro Glu Ala Pro Lys Thr Val Glu Thr 
65                  70                  75                  80  

Glu Thr Pro Ala Thr Asp Lys Val Ala Ser Leu Pro Lys Thr Glu Glu 
                85                  90                  95      

Lys Pro Gln Glu Glu Val Ser Ser Thr Pro Ser Asp Lys Ala Glu Val 
            100                 105                 110         

Val Thr Pro Thr Ser Ala Glu Lys Glu Thr Ala Asn Lys Lys Glu Glu 
        115                 120                 125             

Glu Ala Ser Pro Lys Lys Glu Glu Ala Lys Glu Val Asp Ser Lys Glu 
    130                 135                 140                 

Ser Asn Thr Asp Lys Thr Asp Lys Asp Lys Pro Ala Lys Lys Asp Glu 
145                 150                 155                 160 

Ala Lys Ala Glu Ala Asp Lys Pro Glu Thr Glu Thr Gly Lys Glu Arg 
                165                 170                 175     

Ala Ala Thr Val Asn Glu Lys Leu Ala Lys Lys Lys Ile Val Ser Ile 
            180                 185                 190         

Asp Ala Gly Arg Lys Tyr Phe Ser Pro Glu Gln Leu Lys Glu Ile Ile 
        195                 200                 205             

Asp Lys Ala Lys His Tyr Gly Tyr Thr Asp Leu His Leu Leu Val Gly 
    210                 215                 220                 

Asn Asp Gly Leu Arg Phe Met Leu Asp Asp Met Ser Ile Thr Ala Asn 
225                 230                 235                 240 

Gly Lys Thr Tyr Ala Ser Asp Asp Val Lys Arg Ala Ile Glu Lys Gly 
                245                 250                 255     

Thr Asn Asp Tyr Tyr Asn Asp Pro Asn Gly Asn His Leu Thr Glu Ser 
            260                 265                 270         

Gln Met Thr Asp Leu Ile Asn Tyr Ala Lys Asp Lys Gly Ile Gly Leu 
        275                 280                 285             

Ile Pro Thr Val Asn Ser Pro Gly His Met Asp Ala Ile Leu Asn Ala 
    290                 295                 300                 

Met Lys Glu Leu Gly Ile Gln Asn Pro Asn Phe Ser Tyr Phe Gly Lys 
305                 310                 315                 320 

Lys Ser Ala Arg Thr Val Asp Leu Asp Asn Glu Gln Ala Val Ala Phe 
                325                 330                 335     

Thr Lys Ala Leu Ile Asp Lys Tyr Ala Ala Tyr Phe Ala Lys Lys Thr 
            340                 345                 350         

Glu Ile Phe Asn Ile Gly Leu Asp Glu Tyr Ala Asn Asp Ala Thr Asp 
        355                 360                 365             

Ala Lys Gly Trp Ser Val Leu Gln Ala Asp Lys Tyr Tyr Pro Asn Glu 
    370                 375                 380                 

Gly Tyr Pro Val Lys Gly Tyr Glu Lys Phe Ile Ala Tyr Ala Asn Asp 
385                 390                 395                 400 

Leu Ala Arg Ile Val Lys Ser His Gly Leu Lys Pro Met Ala Phe Asn 
                405                 410                 415     

Asp Gly Ile Tyr Tyr Asn Ser Asp Thr Ser Phe Gly Ser Phe Asp Lys 
            420                 425                 430         

Asp Ile Ile Val Ser Met Trp Thr Gly Gly Trp Gly Gly Tyr Asp Val 
        435                 440                 445             

Ala Ser Ser Lys Leu Leu Ala Glu Lys Gly His Gln Ile Leu Asn Thr 
    450                 455                 460                 

Asn Asp Ala Trp Cys Tyr Val Leu Gly Arg Asn Ala Asp Gly Gln Gly 
465                 470                 475                 480 

Trp Tyr Asn Leu Asp Gln Gly Leu Asn Gly Ile Lys Asn Thr Pro Ile 
                485                 490                 495     

Thr Ser Val Pro Lys Thr Glu Gly Ala Asp Ile Pro Ile Ile Gly Gly 
            500                 505                 510         

Met Val Ala Ala Trp Ala Asp Thr Pro Ser Ala Arg Tyr Ser Pro Ser 
        515                 520                 525             

His Leu Phe Lys Leu Met Arg His Phe Ala Asn Ala Asn Ala Glu Tyr 
    530                 535                 540                 

Phe Ala Ala Asp Tyr Glu Ser Ala Glu Gln Ala Leu Asn Glu Val Pro 
545                 550                 555                 560 

Lys Asp Leu Asn Arg Tyr Thr Ala Glu Ser Val Ala Ala Val Lys Glu 
                565                 570                 575     

Ala Glu Lys Ala Ile Arg Ser Leu Asp Ser Asn Leu Ser Arg Ala Gln 
            580                 585                 590         

Gln Asp Thr Ile Asp Gln Ala Ile Ala Lys Leu Gln Glu Thr Val Asn 
        595                 600                 605             

Asn Leu Thr Leu Thr Pro Glu Ala Gln Lys Glu Glu Glu Ala Lys Arg 
    610                 615                 620                 

Glu Val Glu Lys Leu Ala Lys Asn Lys Val Ile Ser Ile Asp Ala Gly 
625                 630                 635                 640 

Arg Lys Tyr Phe Thr Leu Asp Gln Leu Lys Arg Ile Val Asp Lys Ala 
                645                 650                 655     

Ser Glu Leu Gly Tyr Ser Asp Val His Leu Leu Leu Gly Asn Asp Gly 
            660                 665                 670         

Leu Arg Phe Leu Leu Asn Asp Met Thr Ile Thr Ala Asn Gly Lys Thr 
        675                 680                 685             

Tyr Ala Ser Asp Asp Val Lys Lys Ala Ile Ile Glu Gly Thr Lys Ala 
    690                 695                 700                 

Tyr Tyr Asp Asp Pro Asn Gly Thr Ala Leu Thr Gln Ala Glu Val Thr 
705                 710                 715                 720 

Glu Leu Ile Glu Tyr Ala Lys Ser Lys Asp Ile Gly Leu Ile Pro Ala 
                725                 730                 735     

Ile Asn Ser Pro Gly His Met Asp Ala Met Leu Val Ala Met Glu Lys 
            740                 745                 750         

Leu Gly Ile Lys Asn Pro Gln Ala His Phe Asp Lys Val Ser Lys Thr 
        755                 760                 765             

Thr Met Asp Leu Lys Asn Glu Glu Ala Met Asn Phe Val Lys Ala Leu 
    770                 775                 780                 

Ile Gly Lys Tyr Met Asp Phe Phe Ala Gly Lys Thr Lys Ile Phe Asn 
785                 790                 795                 800 

Phe Gly Thr Asp Glu Tyr Ala Asn Asp Ala Thr Ser Ala Gln Gly Trp 
                805                 810                 815     

Tyr Tyr Leu Lys Trp Tyr Gln Leu Tyr Gly Lys Phe Ala Glu Tyr Ala 
            820                 825                 830         

Asn Thr Leu Ala Ala Met Ala Lys Glu Arg Gly Leu Gln Pro Met Ala 
        835                 840                 845             

Phe Asn Asp Gly Phe Tyr Tyr Glu Asp Lys Asp Asp Val Gln Phe Asp 
    850                 855                 860                 

Lys Asp Val Leu Ile Ser Tyr Trp Ser Lys Gly Trp Trp Gly Tyr Asn 
865                 870                 875                 880 

Leu Ala Ser Pro Gln Tyr Leu Ala Ser Lys Gly Tyr Lys Phe Leu Asn 
                885                 890                 895     

Thr Asn Gly Asp Trp Tyr Tyr Val Ile Gly Asn His Lys Gln Asp Glu 
            900                 905                 910         

Ala Tyr Pro Leu Ser Lys Ala Val Glu Asn Ser Gly Lys Val Pro Phe 
        915                 920                 925             

Asn Gln Leu Ala Ser Thr Lys Tyr Pro Glu Val Asp Leu Pro Thr Val 
    930                 935                 940                 

Gly Ser Met Leu Ser Ile Trp Ala Asp Arg Pro Ser Ala Glu Tyr Lys 
945                 950                 955                 960 

Glu Glu Glu Ile Phe Glu Leu Met Thr Ala Phe Ala Asp His Asn Lys 
                965                 970                 975     

Asp Tyr Phe Arg Ala Asn Tyr Asn Ala Leu Arg Glu Glu Leu Ala Lys 
            980                 985                 990         

Ile Pro Thr Asn Leu Glu Gly Tyr Ser Lys Glu Ser Leu Glu Ala Leu 
        995                 1000                1005            

Asp Ala Ala Lys Thr Ala Leu Asn Tyr Asn Leu Asn Arg Asn Lys Gln 
    1010                1015                1020                

Ala Glu Leu Asp Thr Leu Val Ala Asn Leu Lys Ala Ala Leu Gln Gly 
1025                1030                1035                1040

Leu Lys Pro Ala Ala Thr His Ser Gly Ser Leu Asp Glu Asn Glu Val 
                1045                1050                1055    

Ala Ala Asn Val Glu Thr Arg Pro Glu Leu Ile Thr Arg Thr Glu Glu 
            1060                1065                1070        

Ile Pro Phe Glu Val Ile Lys Lys Glu Asn Pro Asn Leu Pro Ala Gly 
        1075                1080                1085            

Gln Glu Asn Ile Ile Thr Ala Gly Val Lys Gly Glu Arg Thr His Tyr 
    1090                1095                1100                

Ile Ser Val Leu Thr Glu Asn Gly Lys Thr Thr Glu Thr Val Leu Asp 
1105                1110                1115                1120

Ser Gln Val Thr Lys Glu Val Ile Asn Gln Val Val Glu Val Gly Ser 
                1125                1130                1135    

Pro Val Thr His Lys Gly Asp Glu Ser Gly Leu Ala Pro Thr Thr Glu 
            1140                1145                1150        

Val Lys Pro Arg Leu Asp Ile Gln Glu Glu Glu Ile Pro Phe Thr Thr 
        1155                1160                1165            

Val Thr Arg Glu Asn Pro Leu Leu Leu Lys Gly Lys Thr Gln Val Ile 
    1170                1175                1180                

Thr Lys Gly Val Asn Gly His Arg Ser Asn Phe Tyr Ser Val Ser Thr 
1185                1190                1195                1200

Ser Ala Asp Gly Lys Glu Val Lys Thr Leu Val Asn Ser Val Val Ala 
                1205                1210                1215    

Gln Glu Ala Val Thr Gln Ile Val Glu Val Gly Thr Met Val Thr His 
            1220                1225                1230        

Val Gly Asp Glu Asn Gly Gln Ala Ala Ile Ala Glu Glu Lys Pro Lys 
        1235                1240                1245            

Leu Glu Ile Pro Ser Gln Pro Ala Pro Ser Thr Ala Pro Ala Glu Glu 
    1250                1255                1260                

Ser Lys Ala Leu Pro Gln Asp Pro Ala Pro Val Val Thr Glu Lys Lys 
1265                1270                1275                1280

Leu Pro Glu Thr Gly Thr His Asp Ser Ala Glu Leu Val Val Ala Gly 
                1285                1290                1295    

Leu Met Ser Thr Leu Ala Ala Tyr Gly Leu Thr Lys Arg Lys Glu Asp 
            1300                1305                1310        


<210>   2
<211>   1078
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   2
Met Ile Leu Gln Tyr Val Tyr Trp Ser Val Tyr Met Gln Thr Lys Thr 
1               5                   10                  15      

Lys Lys Leu Ile Val Ser Leu Ser Ser Leu Val Leu Ser Gly Phe Leu 
            20                  25                  30          

Leu Asn His Tyr Met Thr Val Gly Ala Glu Glu Thr Thr Thr Asn Thr 
        35                  40                  45              

Ile Gln Gln Ser Gln Lys Glu Val Gln Tyr Gln Gln Arg Asp Thr Lys 
    50                  55                  60                  

Asn Leu Val Glu Asn Gly Asp Phe Gly Gln Thr Glu Asp Gly Ser Ser 
65                  70                  75                  80  

Pro Trp Thr Gly Ser Lys Ala Gln Gly Trp Ser Ala Trp Val Asp Gln 
                85                  90                  95      

Lys Asn Ser Ser Ala Asp Ala Ser Thr Arg Val Ile Glu Ala Lys Asp 
            100                 105                 110         

Gly Ala Ile Thr Ile Ser Ser Pro Glu Lys Leu Arg Ala Ala Val His 
        115                 120                 125             

Arg Met Val Pro Ile Glu Ala Lys Lys Lys Tyr Lys Leu Arg Phe Lys 
    130                 135                 140                 

Ile Lys Thr Asp Asn Lys Val Gly Ile Ala Lys Val Arg Ile Ile Glu 
145                 150                 155                 160 

Glu Ser Gly Lys Asp Lys Arg Leu Trp Asn Ser Ala Thr Thr Ser Gly 
                165                 170                 175     

Thr Lys Asp Trp Gln Thr Ile Glu Ala Asp Tyr Ser Pro Thr Leu Asp 
            180                 185                 190         

Val Asp Lys Ile Lys Leu Glu Leu Phe Tyr Glu Thr Gly Thr Gly Thr 
        195                 200                 205             

Val Ser Phe Lys Asp Ile Glu Leu Val Glu Val Ala Asp Gln Pro Ser 
    210                 215                 220                 

Glu Asp Ser Gln Thr Asp Lys Gln Leu Glu Glu Lys Ile Asp Leu Pro 
225                 230                 235                 240 

Ile Gly Lys Lys His Val Phe Ser Leu Ala Asp Tyr Thr Tyr Lys Val 
                245                 250                 255     

Glu Asn Pro Asp Val Ala Ser Val Lys Asn Gly Ile Leu Glu Pro Leu 
            260                 265                 270         

Lys Glu Gly Thr Thr Asn Val Ile Val Ser Lys Asp Gly Lys Glu Val 
        275                 280                 285             

Lys Lys Ile Pro Leu Lys Ile Leu Ala Ser Val Lys Asp Thr Tyr Thr 
    290                 295                 300                 

Asp Arg Leu Asp Asp Trp Asn Gly Ile Ile Ala Gly Asn Gln Tyr Tyr 
305                 310                 315                 320 

Asp Ser Lys Asn Glu Gln Met Ala Lys Leu Asn Gln Glu Leu Glu Gly 
                325                 330                 335     

Lys Val Ala Asp Ser Leu Ser Ser Ile Ser Ser Gln Ala Asp Arg Ile 
            340                 345                 350         

Tyr Leu Trp Glu Lys Phe Ser Asn Tyr Lys Thr Ser Ala Asn Leu Thr 
        355                 360                 365             

Ala Thr Tyr Arg Lys Leu Glu Glu Met Ala Lys Gln Val Thr Asn Pro 
    370                 375                 380                 

Ser Ser Arg Tyr Tyr Gln Asp Glu Thr Val Val Arg Thr Val Arg Asp 
385                 390                 395                 400 

Ser Met Glu Trp Met His Lys His Val Tyr Asn Ser Glu Lys Ser Ile 
                405                 410                 415     

Val Gly Asn Trp Trp Asp Tyr Glu Ile Gly Thr Pro Arg Ala Ile Asn 
            420                 425                 430         

Asn Thr Leu Ser Leu Met Lys Glu Tyr Phe Ser Asp Glu Glu Ile Lys 
        435                 440                 445             

Lys Tyr Thr Asp Val Ile Glu Lys Phe Val Pro Asp Pro Glu His Phe 
    450                 455                 460                 

Arg Lys Thr Thr Asp Asn Pro Phe Lys Ala Leu Gly Gly Asn Leu Val 
465                 470                 475                 480 

Asp Met Gly Arg Val Lys Val Ile Ala Gly Leu Leu Arg Lys Asp Asp 
                485                 490                 495     

Gln Glu Ile Ser Ser Thr Ile Arg Ser Ile Glu Gln Val Phe Lys Leu 
            500                 505                 510         

Val Asp Gln Gly Glu Gly Phe Tyr Gln Asp Gly Ser Tyr Ile Asp His 
        515                 520                 525             

Thr Asn Val Ala Tyr Thr Gly Ala Tyr Gly Asn Val Leu Ile Asp Gly 
    530                 535                 540                 

Leu Ser Gln Leu Leu Pro Val Ile Gln Lys Thr Lys Asn Pro Ile Asp 
545                 550                 555                 560 

Lys Asp Lys Met Gln Thr Met Tyr His Trp Ile Asp Lys Ser Phe Ala 
                565                 570                 575     

Pro Leu Leu Val Asn Gly Glu Leu Met Asp Met Ser Arg Gly Arg Ser 
            580                 585                 590         

Ile Ser Arg Ala Asn Ser Glu Gly His Val Ala Ala Val Glu Val Leu 
        595                 600                 605             

Arg Gly Ile His Arg Ile Ala Asp Met Ser Glu Gly Glu Thr Lys Gln 
    610                 615                 620                 

Arg Leu Gln Ser Leu Val Lys Thr Ile Val Gln Ser Asp Ser Tyr Tyr 
625                 630                 635                 640 

Asp Val Phe Lys Asn Leu Lys Thr Tyr Lys Asp Ile Ser Leu Met Gln 
                645                 650                 655     

Ser Leu Leu Ser Asp Ala Gly Val Ala Ser Val Pro Arg Thr Ser Tyr 
            660                 665                 670         

Leu Ser Ala Phe Asn Lys Met Asp Lys Thr Ala Met Tyr Asn Ala Glu 
        675                 680                 685             

Lys Gly Phe Gly Phe Gly Leu Ser Leu Phe Ser Ser Arg Thr Leu Asn 
    690                 695                 700                 

Tyr Glu His Met Asn Lys Glu Asn Lys Arg Gly Trp Tyr Thr Ser Asp 
705                 710                 715                 720 

Gly Met Phe Tyr Leu Tyr Asn Gly Asp Leu Ser His Tyr Ser Asp Gly 
                725                 730                 735     

Tyr Trp Pro Thr Val Asn Pro Tyr Lys Met Pro Gly Thr Thr Glu Thr 
            740                 745                 750         

Asp Ala Lys Arg Ala Asp Ser Asp Thr Gly Lys Val Leu Pro Ser Ala 
        755                 760                 765             

Phe Val Gly Thr Ser Lys Leu Asp Asp Ala Asn Ala Thr Ala Thr Met 
    770                 775                 780                 

Asp Phe Thr Asn Trp Asn Gln Thr Leu Thr Ala His Lys Ser Trp Phe 
785                 790                 795                 800 

Met Leu Lys Asp Lys Ile Ala Phe Leu Gly Ser Asn Ile Gln Asn Thr 
                805                 810                 815     

Ser Thr Asp Thr Ala Ala Thr Thr Ile Asp Gln Arg Lys Leu Glu Ser 
            820                 825                 830         

Ser Asn Pro Tyr Lys Val Tyr Val Asn Asp Lys Glu Ala Ser Leu Thr 
        835                 840                 845             

Glu Gln Glu Lys Asp Tyr Pro Glu Thr Gln Ser Val Phe Leu Glu Ser 
    850                 855                 860                 

Ser Asp Ser Lys Lys Asn Ile Gly Tyr Phe Phe Phe Lys Lys Ser Ser 
865                 870                 875                 880 

Ile Ser Met Ser Lys Ala Leu Gln Lys Gly Ala Trp Lys Asp Ile Asn 
                885                 890                 895     

Glu Gly Gln Ser Asp Lys Glu Val Glu Asn Glu Phe Leu Thr Ile Ser 
            900                 905                 910         

Gln Ala His Lys Gln Asn Gly Asp Ser Tyr Gly Tyr Met Leu Ile Pro 
        915                 920                 925             

Asn Val Asp Arg Ala Thr Phe Asn Gln Met Ile Lys Glu Leu Glu Ser 
    930                 935                 940                 

Ser Leu Ile Glu Asn Asn Glu Thr Leu Gln Ser Val Tyr Asp Ala Lys 
945                 950                 955                 960 

Gln Gly Val Trp Gly Ile Val Lys Tyr Asp Asp Ser Val Ser Thr Ile 
                965                 970                 975     

Ser Asn Gln Phe Gln Val Leu Lys Arg Gly Val Tyr Thr Ile Arg Lys 
            980                 985                 990         

Glu Gly Asp Glu Tyr Lys Ile Ala Tyr Tyr Asn Pro Glu Thr Gln Glu 
        995                 1000                1005            

Ser Ala Pro Asp Gln Glu Val Phe Lys Lys Leu Glu Gln Ala Ala Gln 
    1010                1015                1020                

Pro Gln Val Gln Asn Ser Lys Glu Lys Glu Lys Ser Glu Glu Glu Lys 
1025                1030                1035                1040

Asn His Ser Asp Gln Lys Asn Leu Pro Gln Thr Gly Glu Gly Gln Ser 
                1045                1050                1055    

Ile Leu Ala Ser Leu Gly Phe Leu Leu Leu Gly Ala Phe Tyr Leu Phe 
            1060                1065                1070        

Arg Arg Gly Lys Asn Asn 
        1075            

<210>   3
<211>   2228
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   3
Met Gly Lys Gly His Trp Asn Arg Lys Arg Val Tyr Ser Ile Arg Lys 
1               5                   10                  15      

Phe Ala Val Gly Ala Cys Ser Val Met Ile Gly Thr Cys Ala Val Leu 
            20                  25                  30          

Leu Gly Gly Asn Ile Ala Gly Glu Ser Val Val Tyr Ala Asp Glu Thr 
        35                  40                  45              

Leu Ile Thr His Thr Ala Glu Lys Pro Lys Glu Glu Lys Met Ile Val 
    50                  55                  60                  

Glu Glu Lys Ala Asp Lys Ala Leu Glu Thr Lys Asn Val Val Glu Arg 
65                  70                  75                  80  

Thr Glu Gln Ser Glu Pro Ser Ser Thr Glu Ala Ile Ala Ser Glu Lys 
                85                  90                  95      

Lys Glu Asp Glu Ala Val Thr Pro Lys Glu Glu Lys Val Ser Ala Lys 
            100                 105                 110         

Pro Glu Glu Lys Ala Pro Arg Ile Glu Ser Gln Ala Ser Ser Gln Glu 
        115                 120                 125             

Lys Pro Leu Lys Glu Asp Ala Lys Ala Val Thr Asn Glu Glu Val Asn 
    130                 135                 140                 

Gln Met Ile Glu Asn Arg Lys Val Asp Phe Asn Gln Asn Trp Tyr Phe 
145                 150                 155                 160 

Lys Leu Asn Ala Asn Ser Lys Glu Ala Ile Lys Pro Asp Ala Asp Val 
                165                 170                 175     

Ser Thr Trp Lys Lys Leu Asp Leu Pro Tyr Asp Trp Ser Ile Phe Asn 
            180                 185                 190         

Asp Phe Asp His Glu Ser Pro Ala Gln Asn Glu Gly Gly Gln Leu Asn 
        195                 200                 205             

Gly Gly Glu Ala Trp Tyr Arg Lys Thr Phe Lys Leu Asp Glu Lys Asp 
    210                 215                 220                 

Leu Lys Lys Asn Val Arg Leu Thr Phe Asp Gly Val Tyr Met Asp Ser 
225                 230                 235                 240 

Gln Val Tyr Val Asn Gly Gln Leu Val Gly His Tyr Pro Asn Gly Tyr 
                245                 250                 255     

Asn Gln Phe Ser Tyr Asp Ile Thr Lys Tyr Leu Tyr Lys Asp Gly Arg 
            260                 265                 270         

Glu Asn Val Ile Ala Val His Ala Val Asn Lys Gln Pro Ser Ser Arg 
        275                 280                 285             

Trp Tyr Ser Gly Ser Gly Ile Tyr Arg Asp Val Thr Leu Gln Val Thr 
    290                 295                 300                 

Asp Lys Val His Val Glu Lys Asn Gly Thr Thr Ile Leu Thr Pro Lys 
305                 310                 315                 320 

Leu Glu Glu Gln Gln His Gly Lys Val Glu Thr His Val Thr Ser Lys 
                325                 330                 335     

Ile Val Asn Thr Asp Asp Lys Asp His Glu Leu Val Ala Glu Tyr Gln 
            340                 345                 350         

Ile Val Glu Arg Gly Gly His Ala Val Thr Gly Leu Val Arg Thr Ala 
        355                 360                 365             

Ser Arg Thr Leu Lys Ala His Glu Ser Thr Ser Leu Asp Ala Ile Leu 
    370                 375                 380                 

Glu Val Glu Arg Pro Lys Leu Trp Thr Val Leu Asn Asp Lys Pro Ala 
385                 390                 395                 400 

Leu Tyr Glu Leu Ile Thr Arg Val Tyr Arg Asp Gly Gln Leu Val Asp 
                405                 410                 415     

Ala Lys Lys Asp Leu Phe Gly Tyr Arg Tyr Tyr His Trp Thr Pro Asn 
            420                 425                 430         

Glu Gly Phe Ser Leu Asn Gly Glu Arg Ile Lys Phe His Gly Val Ser 
        435                 440                 445             

Leu His His Asp His Gly Ala Leu Gly Ala Glu Glu Asn Tyr Lys Ala 
    450                 455                 460                 

Glu Tyr Arg Arg Leu Lys Gln Met Lys Glu Met Gly Val Asn Ser Ile 
465                 470                 475                 480 

Arg Thr Thr His Asn Pro Ala Ser Glu Gln Thr Leu Gln Ile Ala Ala 
                485                 490                 495     

Glu Leu Gly Leu Leu Val Gln Glu Glu Ala Phe Asp Thr Trp Tyr Gly 
            500                 505                 510         

Gly Lys Lys Pro Tyr Asp Tyr Gly Arg Phe Phe Glu Lys Asp Ala Thr 
        515                 520                 525             

His Pro Glu Ala Arg Lys Gly Glu Lys Trp Ser Asp Phe Asp Leu Arg 
    530                 535                 540                 

Thr Met Val Glu Arg Gly Lys Asn Asn Pro Ala Ile Phe Met Trp Ser 
545                 550                 555                 560 

Ile Gly Asn Glu Ile Gly Glu Ala Asn Gly Asp Ala His Ser Leu Ala 
                565                 570                 575     

Thr Val Lys Arg Leu Val Lys Val Ile Lys Asp Val Asp Lys Thr Arg 
            580                 585                 590         

Tyr Val Thr Met Gly Ala Asp Lys Phe Arg Phe Gly Asn Gly Ser Gly 
        595                 600                 605             

Gly His Glu Lys Ile Ala Asp Glu Leu Asp Ala Val Gly Phe Asn Tyr 
    610                 615                 620                 

Ser Glu Asp Asn Tyr Lys Ala Leu Arg Ala Lys His Pro Lys Trp Leu 
625                 630                 635                 640 

Ile Tyr Gly Ser Glu Thr Ser Ser Ala Thr Arg Thr Arg Gly Ser Tyr 
                645                 650                 655     

Tyr Arg Pro Glu Arg Glu Leu Lys His Ser Asn Gly Pro Glu Arg Asn 
            660                 665                 670         

Tyr Glu Gln Ser Asp Tyr Gly Asn Asp Arg Val Gly Trp Gly Lys Thr 
        675                 680                 685             

Ala Thr Ala Ser Trp Thr Phe Asp Arg Asp Asn Ala Gly Tyr Ala Gly 
    690                 695                 700                 

Gln Phe Ile Trp Thr Gly Thr Asp Tyr Ile Gly Glu Pro Thr Pro Trp 
705                 710                 715                 720 

His Asn Gln Asn Gln Thr Pro Val Lys Ser Ser Tyr Phe Gly Ile Val 
                725                 730                 735     

Asp Thr Ala Gly Ile Pro Lys His Asp Phe Tyr Leu Tyr Gln Ser Gln 
            740                 745                 750         

Trp Val Ser Val Lys Lys Lys Pro Met Val His Leu Leu Pro His Trp 
        755                 760                 765             

Asn Trp Glu Asn Lys Glu Leu Ala Ser Lys Val Ala Asp Ser Glu Gly 
    770                 775                 780                 

Lys Ile Pro Val Arg Ala Tyr Ser Asn Ala Ser Ser Val Glu Leu Phe 
785                 790                 795                 800 

Leu Asn Gly Lys Ser Leu Gly Leu Lys Thr Phe Asn Lys Lys Gln Thr 
                805                 810                 815     

Ser Asp Gly Arg Thr Tyr Gln Glu Gly Ala Asn Ala Asn Glu Leu Tyr 
            820                 825                 830         

Leu Glu Trp Lys Val Ala Tyr Gln Pro Gly Thr Leu Glu Ala Ile Ala 
        835                 840                 845             

Arg Asp Glu Ser Gly Lys Glu Ile Ala Arg Asp Lys Ile Thr Thr Ala 
    850                 855                 860                 

Gly Lys Pro Ala Ala Val Arg Leu Ile Lys Glu Asp His Ala Ile Ala 
865                 870                 875                 880 

Ala Asp Gly Lys Asp Leu Thr Tyr Ile Tyr Tyr Glu Ile Val Asp Ser 
                885                 890                 895     

Gln Gly Asn Val Val Pro Thr Ala Asn Asn Leu Val Arg Phe Gln Leu 
            900                 905                 910         

His Gly Gln Gly Gln Leu Val Gly Val Asp Asn Gly Glu Gln Ala Ser 
        915                 920                 925             

Arg Glu Arg Tyr Lys Ala Gln Ala Asp Gly Ser Trp Ile Arg Lys Ala 
    930                 935                 940                 

Phe Asn Gly Lys Gly Val Ala Ile Val Lys Ser Thr Glu Gln Ala Gly 
945                 950                 955                 960 

Lys Phe Thr Leu Thr Ala His Ser Asp Leu Leu Lys Ser Asn Gln Val 
                965                 970                 975     

Thr Val Phe Thr Gly Lys Lys Glu Gly Gln Glu Lys Thr Val Leu Gly 
            980                 985                 990         

Thr Glu Val Pro Lys Val Gln Thr Ile Ile Gly Glu Ala Pro Glu Met 
        995                 1000                1005            

Pro Thr Thr Val Pro Phe Val Tyr Ser Asp Gly Ser Arg Ala Glu Arg 
    1010                1015                1020                

Pro Val Thr Trp Ser Leu Val Asp Val Ser Lys Pro Gly Ile Val Thr 
1025                1030                1035                1040

Val Lys Gly Met Ala Asp Gly Arg Glu Val Glu Ala Arg Val Glu Val 
                1045                1050                1055    

Ile Ala Leu Lys Ser Glu Leu Pro Val Val Lys Arg Ile Ala Pro Asn 
            1060                1065                1070        

Thr Asn Leu Asn Ser Val Asp Lys Ser Val Ser Tyr Val Leu Thr Asp 
        1075                1080                1085            

Gly Ser Val Gln Glu Tyr Glu Val Asp Lys Trp Glu Ile Ala Glu Glu 
    1090                1095                1100                

Asp Lys Ala Lys Leu Ala Ile Pro Gly Ser Arg Ile Gln Ala Thr Gly 
1105                1110                1115                1120

Tyr Leu Glu Gly Gln Pro Ile His Ala Thr Leu Val Val Glu Glu Gly 
                1125                1130                1135    

Asn Pro Ala Ala Pro Val Val Pro Thr Val Thr Val Gly Gly Glu Ala 
            1140                1145                1150        

Val Thr Gly Leu Thr Ser Arg Gln Pro Met Gln Tyr Arg Thr Leu Ser 
        1155                1160                1165            

Tyr Gly Ala Gln Leu Pro Glu Val Thr Ala Ser Ala Glu Asn Ala Asp 
    1170                1175                1180                

Val Thr Val Leu Gln Ala Ser Ala Ala Asn Gly Met Arg Ala Ser Ile 
1185                1190                1195                1200

Phe Ile Gln Pro Lys Asp Gly Gly Pro Leu Gln Thr Tyr Ala Ile Gln 
                1205                1210                1215    

Phe Leu Glu Glu Ala Pro Lys Ile Ala His Leu Ser Leu Gln Val Glu 
            1220                1225                1230        

Lys Ala Asp Ser Leu Lys Glu Asp Gln Thr Val Lys Leu Ser Val Arg 
        1235                1240                1245            

Ala His Tyr Gln Asp Gly Thr Gln Ala Val Leu Pro Ala Asp Lys Val 
    1250                1255                1260                

Thr Phe Ser Thr Ser Gly Glu Gly Glu Val Ala Ile Arg Lys Gly Met 
1265                1270                1275                1280

Leu Glu Leu His Lys Pro Gly Ala Val Thr Leu Asn Ala Glu Tyr Glu 
                1285                1290                1295    

Gly Ala Lys Gly Gln Val Glu Leu Thr Ile Gln Ala Asn Thr Glu Lys 
            1300                1305                1310        

Lys Ile Ala Gln Ser Ile Arg Pro Val Asn Val Val Thr Asp Leu His 
        1315                1320                1325            

Gln Glu Pro Ser Leu Pro Ala Thr Val Thr Val Glu Tyr Asp Lys Gly 
    1330                1335                1340                

Phe Pro Lys Thr His Lys Val Thr Trp Gln Ala Ile Pro Lys Glu Lys 
1345                1350                1355                1360

Leu Asp Ser Tyr Gln Ile Phe Glu Val Leu Gly Lys Val Glu Gly Ile 
                1365                1370                1375    

Asp Leu Glu Ala Arg Ala Lys Val Ser Val Glu Gly Ile Val Ser Val 
            1380                1385                1390        

Glu Glu Val Ser Val Thr Thr Pro Ile Ala Glu Ala Pro Gln Leu Pro 
        1395                1400                1405            

Glu Ser Val Arg Thr Tyr Asp Ser Asn Gly His Val Ser Ser Ala Lys 
    1410                1415                1420                

Val Ala Trp Asp Ala Ile Arg Pro Glu Gln Tyr Ala Lys Glu Gly Val 
1425                1430                1435                1440

Phe Thr Val Asn Gly Arg Leu Glu Gly Thr Gln Leu Thr Thr Lys Leu 
                1445                1450                1455    

His Val Arg Val Ser Ala Gln Thr Glu Gln Gly Ala Asn Ile Ser Asp 
            1460                1465                1470        

Gln Trp Thr Gly Ser Glu Leu Pro Leu Ala Phe Ala Ser Asp Ser Asn 
        1475                1480                1485            

Pro Ser Asp Pro Val Ser Asn Val Asn Asp Lys Leu Ile Ser Tyr Asn 
    1490                1495                1500                

Asn Gln Pro Ala Asn Arg Trp Thr Asn Trp Asn Arg Ser Asn Pro Glu 
1505                1510                1515                1520

Ala Ser Val Gly Val Leu Phe Gly Asp Ser Gly Ile Leu Ser Lys Arg 
                1525                1530                1535    

Ser Val Asp Asn Leu Ser Val Gly Phe His Glu Asp His Gly Val Gly 
            1540                1545                1550        

Ala Pro Lys Ser Tyr Val Ile Glu Tyr Tyr Val Gly Lys Thr Val Pro 
        1555                1560                1565            

Thr Ala Pro Lys Asn Pro Ser Phe Val Gly Asn Glu Asp His Val Phe 
    1570                1575                1580                

Asn Asp Ser Ala Asn Trp Lys Pro Val Thr Asn Leu Lys Ala Pro Ala 
1585                1590                1595                1600

Gln Leu Lys Ala Gly Glu Met Asn His Phe Ser Phe Asp Lys Val Glu 
                1605                1610                1615    

Thr Tyr Ala Ile Arg Ile Arg Met Val Lys Ala Asp Asn Lys Arg Gly 
            1620                1625                1630        

Thr Ser Ile Thr Glu Val Gln Ile Phe Ala Lys Gln Val Ala Ala Ala 
        1635                1640                1645            

Lys Gln Gly Gln Thr Arg Ile Gln Val Asp Gly Lys Asp Leu Ala Asn 
    1650                1655                1660                

Phe Asn Pro Asp Leu Thr Asp Tyr Tyr Leu Glu Ser Val Asp Gly Lys 
1665                1670                1675                1680

Val Pro Ala Val Thr Ala Asn Val Ser Asn Asn Gly Leu Ala Thr Val 
                1685                1690                1695    

Val Pro Ser Val Arg Glu Gly Glu Pro Val Arg Val Ile Ala Lys Ala 
            1700                1705                1710        

Glu Asn Gly Asp Ile Leu Gly Glu Tyr Arg Leu His Phe Thr Lys Asp 
        1715                1720                1725            

Lys Asn Leu Leu Ser His Lys Pro Val Ala Ala Val Lys Gln Ala Arg 
    1730                1735                1740                

Leu Leu Gln Val Gly Gln Ala Leu Glu Leu Pro Thr Lys Val Pro Val 
1745                1750                1755                1760

Tyr Phe Thr Gly Lys Asp Gly Tyr Glu Thr Lys Asp Leu Thr Val Glu 
                1765                1770                1775    

Trp Glu Glu Val Pro Ala Glu Asn Leu Thr Lys Ala Gly Gln Phe Thr 
            1780                1785                1790        

Val Arg Gly Arg Val Leu Gly Ser Asn Leu Val Ala Glu Val Thr Val 
        1795                1800                1805            

Arg Val Thr Asp Lys Leu Gly Glu Thr Leu Ser Asp Asn Pro Asn Tyr 
    1810                1815                1820                

Asp Glu Asn Ser Asn Gln Ala Phe Ala Ser Ala Thr Asn Asp Ile Asp 
1825                1830                1835                1840

Lys Asn Ser His Asp Arg Val Asp Tyr Leu Asn Asp Gly Asp His Ser 
                1845                1850                1855    

Glu Asn Arg Arg Trp Thr Asn Trp Ser Pro Thr Pro Ser Ser Asn Pro 
            1860                1865                1870        

Glu Val Ser Ala Gly Val Ile Phe Arg Glu Asn Gly Lys Ile Val Glu 
        1875                1880                1885            

Arg Thr Val Ala Gln Ala Lys Leu His Phe Phe Ala Asp Ser Gly Thr 
    1890                1895                1900                

Asp Ala Pro Ser Lys Leu Val Leu Glu Arg Tyr Val Gly Pro Gly Phe 
1905                1910                1915                1920

Glu Val Pro Thr Tyr Tyr Ser Asn Tyr Gln Ala Tyr Glu Ser Gly His 
                1925                1930                1935    

Pro Phe Asn Asn Pro Glu Asn Trp Glu Ala Val Pro Tyr Arg Ala Asp 
            1940                1945                1950        

Lys Asp Ile Ala Ala Gly Asp Glu Ile Asn Val Thr Phe Lys Ala Val 
        1955                1960                1965            

Lys Ala Lys Val Met Arg Trp Arg Met Glu Arg Lys Ala Asp Lys Ser 
    1970                1975                1980                

Gly Val Ala Met Ile Glu Met Thr Phe Leu Ala Pro Ser Glu Leu Pro 
1985                1990                1995                2000

Gln Glu Ser Thr Gln Ser Lys Ile Leu Val Asp Gly Lys Glu Leu Ala 
                2005                2010                2015    

Asp Phe Ala Glu Asn Arg Gln Asp Tyr Gln Ile Thr Tyr Lys Gly Gln 
            2020                2025                2030        

Arg Pro Lys Val Ser Val Glu Glu Asn Asn Gln Val Ala Ser Thr Val 
        2035                2040                2045            

Val Asp Ser Gly Glu Asp Ser Leu Pro Val Leu Val Arg Leu Val Ser 
    2050                2055                2060                

Glu Ser Gly Lys Gln Val Lys Glu Tyr Arg Ile Gln Leu Thr Lys Glu 
2065                2070                2075                2080

Lys Pro Val Ser Ala Val Gln Glu Asp Leu Pro Lys Leu Glu Phe Val 
                2085                2090                2095    

Glu Lys Asp Leu Ala Tyr Lys Thr Val Glu Lys Lys Asp Ser Thr Leu 
            2100                2105                2110        

Tyr Leu Gly Glu Thr Arg Val Glu Gln Glu Gly Lys Val Gly Lys Glu 
        2115                2120                2125            

Arg Ile Phe Thr Val Ile Asn Pro Asp Gly Ser Lys Glu Glu Lys Leu 
    2130                2135                2140                

Arg Glu Val Val Glu Val Pro Thr Asp Arg Ile Val Leu Val Gly Thr 
2145                2150                2155                2160

Lys Pro Val Ala Gln Glu Ala Lys Lys Pro Gln Val Ser Glu Lys Ala 
                2165                2170                2175    

Asp Thr Lys Pro Ile Asp Ser Ser Glu Ala Asp Gln Thr Asn Lys Ala 
            2180                2185                2190        

Gln Leu Pro Asn Thr Gly Ser Ala Ala Ser Gln Ala Ala Val Ala Ala 
        2195                2200                2205            

Gly Leu Ala Leu Leu Gly Leu Ser Ala Gly Leu Val Val Thr Lys Gly 
    2210                2215                2220                

Lys Lys Glu Asp 
2225            

<210>   4
<211>   247
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   4
Met Ser Gln Lys Asn Asn Lys Lys Lys Asn Lys Arg Lys Asn Leu Leu 
1               5                   10                  15      

Thr Asn Ile Leu Ala Gly Phe Leu Ile Leu Leu Ser Leu Ala Leu Ile 
            20                  25                  30          

Phe Asn Thr Gln Ile Arg Asn Ile Phe Ile Val Trp Asn Thr Asn Lys 
        35                  40                  45              

Tyr Gln Val Ser Gln Val Ser Lys Glu Lys Leu Glu Glu Asn Gln Asp 
    50                  55                  60                  

Thr Glu Gly Asn Phe Asp Phe Asp Ser Val Lys Ala Ile Ser Ser Glu 
65                  70                  75                  80  

Ala Val Leu Thr Ser Gln Trp Asp Ala Gln Lys Leu Pro Val Ile Gly 
                85                  90                  95      

Gly Ile Ala Ile Pro Glu Leu Glu Met Asn Leu Pro Ile Phe Lys Gly 
            100                 105                 110         

Leu Asp Asn Val Asn Leu Phe Tyr Gly Ala Gly Thr Met Lys Arg Glu 
        115                 120                 125             

Gln Val Met Gly Glu Gly Asn Tyr Ser Leu Ala Ser His His Ile Phe 
    130                 135                 140                 

Gly Val Asp Asn Ala Asn Lys Met Leu Phe Ser Pro Leu Asp Asn Ala 
145                 150                 155                 160 

Lys Asn Gly Met Lys Ile Tyr Leu Thr Asp Lys Asn Lys Val Tyr Thr 
                165                 170                 175     

Tyr Glu Ile Arg Glu Val Lys Arg Val Thr Pro Asp Arg Val Asp Glu 
            180                 185                 190         

Val Asp Asp Arg Asp Gly Val Asn Glu Ile Thr Leu Val Thr Cys Glu 
        195                 200                 205             

Asp Leu Ala Ala Thr Glu Arg Ile Ile Val Lys Gly Asp Leu Lys Glu 
    210                 215                 220                 

Thr Lys Asp Tyr Ser Gln Thr Ser Asp Glu Ile Leu Thr Ala Phe Asn 
225                 230                 235                 240 

Gln Pro Tyr Lys Gln Phe Tyr 
                245         

<210>   5
<211>   202
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   5
Met Val Pro Lys Thr Ala Thr Ser Thr Glu Thr Lys Thr Ile Thr Arg 
1               5                   10                  15      

Ile Ile His Tyr Val Asp Lys Val Thr Asn Gln Asn Val Lys Glu Asp 
            20                  25                  30          

Val Val Gln Pro Val Thr Leu Ser Arg Thr Lys Thr Glu Asn Lys Val 
        35                  40                  45              

Thr Gly Val Val Thr Tyr Gly Glu Trp Thr Thr Gly Asn Trp Asp Glu 
    50                  55                  60                  

Val Ile Ser Gly Lys Ile Asp Lys Tyr Lys Asp Pro Asp Ile Pro Thr 
65                  70                  75                  80  

Val Glu Ser Gln Glu Val Thr Ser Asp Ser Ser Asp Lys Glu Ile Thr 
                85                  90                  95      

Val Arg Tyr Asp Arg Leu Ser Thr Pro Glu Lys Pro Ile Pro Gln Pro 
            100                 105                 110         

Asn Pro Glu His Pro Ser Val Pro Thr Pro Asn Pro Glu Leu Pro Asn 
        115                 120                 125             

Gln Glu Thr Pro Thr Pro Asp Lys Pro Thr Pro Glu Pro Gly Thr Pro 
    130                 135                 140                 

Lys Thr Glu Thr Pro Val Asn Pro Asp Pro Glu Val Pro Thr Tyr Glu 
145                 150                 155                 160 

Thr Gly Lys Arg Glu Glu Leu Pro Asn Thr Gly Thr Glu Ala Asn Ala 
                165                 170                 175     

Thr Leu Ala Ser Ala Gly Ile Met Thr Leu Leu Ala Gly Leu Gly Leu 
            180                 185                 190         

Gly Phe Phe Lys Lys Lys Glu Asp Glu Lys 
        195                 200         

<210>   6
<211>   128
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   6
Met Glu Lys Asp Met Asn Leu Lys Arg Glu Gln Glu Phe Val Ser Gln 
1               5                   10                  15      

Tyr His Phe Asp Ala Arg Asn Phe Glu Trp Glu Asn Glu Asn Gly Ala 
            20                  25                  30          

Pro Glu Thr Lys Val Asp Val Asn Phe Gln Leu Leu Gln His Asp Gln 
        35                  40                  45              

Glu Asn Gln Val Thr Ser Leu Ile Val Ile Leu Ser Phe Met Ile Val 
    50                  55                  60                  

Phe Asp Lys Phe Val Ile Ser Gly Thr Ile Ser Gln Val Asn His Ile 
65                  70                  75                  80  

Asp Gly Arg Ile Val Asn Glu Pro Asn Glu Leu Asn Gln Glu Glu Val 
                85                  90                  95      

Glu Thr Leu Ala Arg Pro Cys Leu Asn Met Leu Asn Arg Leu Thr Tyr 
            100                 105                 110         

Glu Val Thr Glu Ile Ala Leu Asp Leu Pro Gly Ile Asn Leu Glu Phe 
        115                 120                 125             


<210>   7
<211>   259
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   7
Met Lys Lys Asn Ser Leu Tyr Ile Ile Ser Ser Leu Phe Phe Ala Cys 
1               5                   10                  15      

Val Leu Phe Val Tyr Ala Thr Ala Thr Asn Phe Gln Asn Ser Thr Ser 
            20                  25                  30          

Ala Arg Gln Val Lys Thr Glu Thr Tyr Thr Asn Thr Val Thr Asn Val 
        35                  40                  45              

Pro Ile Asp Ile Arg Tyr Asn Ser Asp Lys Tyr Phe Ile Ser Gly Phe 
    50                  55                  60                  

Ala Ser Glu Val Ser Val Val Leu Thr Gly Ala Asn Arg Leu Ser Leu 
65                  70                  75                  80  

Ala Ser Glu Met Gln Glu Ser Thr Arg Lys Phe Lys Val Thr Ala Asp 
                85                  90                  95      

Leu Thr Asp Ala Gly Val Gly Thr Ile Glu Val Pro Leu Ser Ile Glu 
            100                 105                 110         

Asp Leu Pro Asn Gly Leu Thr Ala Val Ala Thr Pro Gln Lys Ile Thr 
        115                 120                 125             

Val Lys Ile Gly Lys Lys Ala Gln Lys Asp Lys Val Lys Ile Val Pro 
    130                 135                 140                 

Glu Ile Asp Pro Ser Gln Ile Asp Ser Arg Val Gln Ile Glu Asn Val 
145                 150                 155                 160 

Met Val Ser Asp Lys Glu Val Ser Ile Thr Ser Asp Gln Glu Thr Leu 
                165                 170                 175     

Asp Arg Ile Asp Lys Ile Ile Ala Val Leu Pro Thr Ser Glu Arg Ile 
            180                 185                 190         

Thr Gly Asn Tyr Ser Gly Ser Val Pro Leu Gln Ala Ile Asp Arg Asn 
        195                 200                 205             

Gly Val Val Leu Pro Ala Val Ile Thr Pro Phe Asp Thr Ile Met Lys 
    210                 215                 220                 

Val Thr Thr Lys Pro Val Ala Pro Ser Ser Ser Thr Ser Asn Ser Ser 
225                 230                 235                 240 

Thr Ser Ser Ser Ser Glu Thr Ser Ser Ser Thr Lys Ala Thr Ser Ser 
                245                 250                 255     

Lys Thr Asn 
            

<210>   8
<211>   721
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   8
Met Asn Leu Gly Glu Phe Trp Tyr Asn Lys Ile Asn Lys Asn Arg Gly 
1               5                   10                  15      

Arg Arg Leu Met Lys Lys Val Arg Phe Ile Phe Leu Ala Leu Leu Phe 
            20                  25                  30          

Phe Leu Ala Ser Pro Glu Gly Ala Met Ala Ser Asp Gly Thr Trp Gln 
        35                  40                  45              

Gly Lys Gln Tyr Leu Lys Glu Asp Gly Ser Gln Ala Ala Asn Glu Trp 
    50                  55                  60                  

Val Phe Asp Thr His Tyr Gln Ser Trp Phe Tyr Ile Lys Ala Asp Ala 
65                  70                  75                  80  

Asn Tyr Ala Glu Asn Glu Trp Leu Lys Gln Gly Asp Asp Tyr Phe Tyr 
                85                  90                  95      

Leu Lys Ser Gly Gly Tyr Met Ala Lys Ser Glu Trp Val Glu Asp Lys 
            100                 105                 110         

Gly Ala Phe Tyr Tyr Leu Asp Gln Asp Gly Lys Met Lys Arg Asn Ala 
        115                 120                 125             

Trp Val Gly Thr Ser Tyr Val Gly Ala Thr Gly Ala Lys Val Ile Glu 
    130                 135                 140                 

Asp Trp Val Tyr Asp Ser Gln Tyr Asp Ala Trp Phe Tyr Ile Lys Ala 
145                 150                 155                 160 

Asp Gly Gln His Ala Glu Lys Glu Trp Leu Gln Ile Lys Gly Lys Asp 
                165                 170                 175     

Tyr Tyr Phe Lys Ser Gly Gly Tyr Leu Leu Thr Ser Gln Trp Ile Asn 
            180                 185                 190         

Gln Ala Tyr Val Asn Ala Ser Gly Ala Lys Val Gln Gln Gly Trp Leu 
        195                 200                 205             

Phe Asp Lys Gln Tyr Gln Ser Trp Phe Tyr Ile Lys Glu Asn Gly Asn 
    210                 215                 220                 

Tyr Ala Asp Lys Glu Trp Ile Phe Glu Asn Gly His Tyr Tyr Tyr Leu 
225                 230                 235                 240 

Lys Ser Gly Gly Tyr Met Ala Ala Asn Glu Trp Ile Trp Asp Lys Glu 
                245                 250                 255     

Ser Trp Phe Tyr Leu Lys Phe Asp Gly Lys Ile Ala Glu Lys Glu Trp 
            260                 265                 270         

Val Tyr Asp Ser His Ser Gln Ala Trp Tyr Tyr Phe Lys Ser Gly Gly 
        275                 280                 285             

Tyr Met Ala Ala Asn Glu Trp Ile Trp Asp Lys Glu Ser Trp Phe Tyr 
    290                 295                 300                 

Leu Lys Phe Asp Gly Lys Met Ala Glu Lys Glu Trp Val Tyr Asp Ser 
305                 310                 315                 320 

His Ser Gln Ala Trp Tyr Tyr Phe Lys Ser Gly Gly Tyr Met Thr Ala 
                325                 330                 335     

Asn Glu Trp Ile Trp Asp Lys Glu Ser Trp Phe Tyr Leu Lys Ser Asp 
            340                 345                 350         

Gly Lys Ile Ala Glu Lys Glu Trp Val Tyr Asp Ser His Ser Gln Ala 
        355                 360                 365             

Trp Tyr Tyr Phe Lys Ser Gly Gly Tyr Met Thr Ala Asn Glu Trp Ile 
    370                 375                 380                 

Trp Asp Lys Glu Ser Trp Phe Tyr Leu Lys Ser Asp Gly Lys Met Ala 
385                 390                 395                 400 

Glu Lys Glu Trp Val Tyr Asp Ser His Ser Gln Ala Trp Tyr Tyr Phe 
                405                 410                 415     

Lys Ser Gly Gly Tyr Met Ala Lys Asn Glu Thr Val Asp Gly Tyr Gln 
            420                 425                 430         

Leu Gly Ser Asp Gly Lys Trp Leu Gly Gly Lys Ala Thr Asn Lys Asn 
        435                 440                 445             

Ala Ala Tyr Tyr Gln Val Val Pro Val Thr Ala Asn Val Tyr Asp Ser 
    450                 455                 460                 

Asp Gly Glu Lys Leu Ser Tyr Ile Ser Gln Gly Ser Val Val Trp Leu 
465                 470                 475                 480 

Asp Lys Asp Arg Lys Ser Asp Asp Lys Arg Leu Ala Ile Thr Ile Ser 
                485                 490                 495     

Gly Leu Ser Gly Tyr Met Lys Thr Glu Asp Leu Gln Ala Leu Asp Ala 
            500                 505                 510         

Ser Lys Asp Phe Ile Pro Tyr Tyr Glu Ser Asp Gly His Arg Phe Tyr 
        515                 520                 525             

His Tyr Val Ala Gln Asn Ala Ser Ile Pro Val Ala Ser His Leu Ser 
    530                 535                 540                 

Asp Met Glu Val Gly Lys Lys Tyr Tyr Ser Ala Asp Gly Leu His Phe 
545                 550                 555                 560 

Asp Gly Phe Lys Leu Glu Asn Pro Phe Leu Phe Lys Asp Leu Thr Glu 
                565                 570                 575     

Ala Thr Asn Tyr Ser Ala Glu Glu Leu Asp Lys Val Phe Ser Leu Leu 
            580                 585                 590         

Asn Ile Asn Asn Ser Leu Leu Glu Asn Lys Gly Ala Thr Phe Lys Glu 
        595                 600                 605             

Ala Glu Glu His Tyr His Ile Asn Ala Leu Tyr Leu Leu Ala His Ser 
    610                 615                 620                 

Ala Leu Glu Ser Asn Trp Gly Arg Ser Lys Ile Ala Lys Asp Lys Asn 
625                 630                 635                 640 

Asn Phe Phe Gly Ile Thr Ala Tyr Asp Thr Thr Pro Tyr Leu Ser Ala 
                645                 650                 655     

Lys Thr Phe Asp Asp Val Asp Lys Gly Ile Leu Gly Ala Thr Lys Trp 
            660                 665                 670         

Ile Lys Glu Asn Tyr Ile Asp Arg Gly Arg Thr Phe Leu Gly Asn Lys 
        675                 680                 685             

Ala Ser Gly Met Asn Val Glu Tyr Ala Ser Asp Pro Tyr Trp Gly Glu 
    690                 695                 700                 

Lys Ile Ala Ser Val Met Met Lys Ile Asn Glu Lys Leu Gly Gly Lys 
705                 710                 715                 720 

Asp 
    

<210>   9
<211>   501
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   9
Met Ser Val Thr Phe Phe Ile Gly Glu Glu Arg Leu Lys Ile Lys Ile 
1               5                   10                  15      

Gly Leu Ala Ser Ile Cys Leu Leu Gly Leu Ala Thr Ser His Val Ala 
            20                  25                  30          

Ala Asn Glu Thr Glu Val Ala Lys Thr Ser Gln Asp Thr Thr Thr Ala 
        35                  40                  45              

Ser Ser Ser Ser Glu Gln Asn Gln Ser Ser Asn Lys Thr Gln Thr Ser 
    50                  55                  60                  

Ala Glu Val Gln Thr Asn Ala Ala Ala Tyr Trp Asp Gly Asp Tyr Tyr 
65                  70                  75                  80  

Val Lys Asp Asp Gly Ser Lys Ala Gln Ser Glu Trp Ile Phe Asp Asn 
                85                  90                  95      

Tyr Tyr Lys Ala Trp Phe Tyr Ile Asn Ser Asp Gly Arg Tyr Ser Gln 
            100                 105                 110         

Asn Glu Trp His Gly Asn Tyr Tyr Leu Lys Ser Gly Gly Tyr Met Ala 
        115                 120                 125             

Gln Asn Glu Trp Ile Tyr Asp Ser Asn Tyr Lys Ser Trp Phe Tyr Leu 
    130                 135                 140                 

Lys Ser Asp Gly Ala Tyr Ala His Gln Glu Trp Gln Leu Ile Gly Asn 
145                 150                 155                 160 

Lys Trp Tyr Tyr Phe Lys Lys Trp Gly Tyr Met Ala Lys Ser Gln Trp 
                165                 170                 175     

Gln Gly Ser Tyr Phe Leu Asn Gly Gln Gly Ala Met Ile Gln Asn Glu 
            180                 185                 190         

Trp Leu Tyr Asp Pro Ala Tyr Ser Ala Tyr Phe Tyr Leu Lys Ser Asp 
        195                 200                 205             

Gly Thr Tyr Ala Asn Gln Glu Trp Gln Lys Val Gly Gly Lys Trp Tyr 
    210                 215                 220                 

Tyr Phe Lys Lys Trp Gly Tyr Met Ala Arg Asn Glu Trp Gln Gly Asn 
225                 230                 235                 240 

Tyr Tyr Leu Thr Gly Ser Gly Ala Met Ala Thr Asp Glu Val Ile Met 
                245                 250                 255     

Asp Gly Ala Arg Tyr Ile Phe Ala Ala Ser Gly Glu Leu Lys Glu Lys 
            260                 265                 270         

Lys Asp Leu Asn Val Gly Trp Val His Arg Asp Gly Lys Arg Tyr Phe 
        275                 280                 285             

Phe Asn Asn Arg Glu Glu Gln Val Gly Thr Glu His Ala Lys Lys Ile 
    290                 295                 300                 

Ile Asp Ile Ser Glu His Asn Gly Arg Ile Asn Asp Trp Lys Lys Val 
305                 310                 315                 320 

Ile Asp Glu Asn Lys Val Asp Gly Val Ile Val Arg Leu Gly Tyr Ser 
                325                 330                 335     

Gly Lys Glu Asp Lys Glu Leu Ala His Asn Ile Lys Glu Leu Asn Arg 
            340                 345                 350         

Leu Gly Ile Pro Tyr Gly Val Tyr Leu Tyr Thr Tyr Ala Glu Asn Glu 
        355                 360                 365             

Thr Asp Ala Glu Asn Asp Ala Lys Gln Thr Ile Glu Leu Ile Lys Lys 
    370                 375                 380                 

Tyr Asn Met Asn Leu Ser Tyr Pro Ile Tyr Tyr Asp Val Glu Asn Trp 
385                 390                 395                 400 

Glu Tyr Val Asn Lys Ser Lys Arg Ala Pro Ser Asp Thr Asp Thr Trp 
                405                 410                 415     

Val Lys Ile Ile Asn Lys Tyr Met Asp Thr Met Lys Gln Ala Gly Tyr 
            420                 425                 430         

Gln Asn Val Tyr Val Tyr Ser Tyr Arg Ser Leu Leu Gln Thr Arg Leu 
        435                 440                 445             

Lys His Pro Asp Ile Leu Lys His Val Asn Trp Val Ala Ala Tyr Thr 
    450                 455                 460                 

Asn Ala Leu Glu Trp Glu Asn Pro Tyr Tyr Ser Gly Glu Lys Gly Trp 
465                 470                 475                 480 

Gln Tyr Thr Ser Ser Glu Tyr Met Lys Gly Ile Gln Gly Arg Val Asp 
                485                 490                 495     

Val Ser Val Trp Tyr 
            500     

<210>   10
<211>   471
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   10
Met Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp 
1               5                   10                  15      

Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe 
            20                  25                  30          

Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg 
        35                  40                  45              

Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala 
    50                  55                  60                  

Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
65                  70                  75                  80  

Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
                85                  90                  95      

Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
            100                 105                 110         

Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
        115                 120                 125             

Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
    130                 135                 140                 

Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln 
145                 150                 155                 160 

Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
                165                 170                 175     

Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
            180                 185                 190         

Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
        195                 200                 205             

Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
    210                 215                 220                 

Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val 
225                 230                 235                 240 

Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
                245                 250                 255     

Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val 
            260                 265                 270         

Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys 
        275                 280                 285             

Ala Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr 
    290                 295                 300                 

Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe 
305                 310                 315                 320 

Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu 
                325                 330                 335     

Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu 
            340                 345                 350         

Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser 
        355                 360                 365             

Gly Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asp Glu Leu Ser Tyr 
    370                 375                 380                 

Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn 
385                 390                 395                 400 

Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly 
                405                 410                 415     

Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala 
            420                 425                 430         

Trp Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val 
        435                 440                 445             

Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gln Val 
    450                 455                 460                 

Glu Asp Lys Val Glu Asn Asp 
465                 470     

<210>   11
<211>   392
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   11
Met Lys Lys Lys Ile Leu Ala Ser Leu Leu Leu Ser Thr Val Met Val 
1               5                   10                  15      

Ser Gln Val Ala Val Leu Thr Thr Ala His Ala Glu Thr Thr Asp Asp 
            20                  25                  30          

Lys Ile Ala Ala Gln Asp Asn Lys Ile Ser Asn Leu Thr Ala Gln Gln 
        35                  40                  45              

Gln Glu Ala Gln Lys Gln Val Asp Gln Ile Gln Glu Gln Val Ser Ala 
    50                  55                  60                  

Ile Gln Ala Glu Gln Ser Asn Leu Gln Ala Glu Asn Asp Arg Leu Gln 
65                  70                  75                  80  

Ala Glu Ser Lys Lys Leu Glu Gly Glu Ile Thr Glu Leu Ser Lys Asn 
                85                  90                  95      

Ile Val Ser Arg Asn Gln Ser Leu Glu Lys Gln Ala Arg Ser Ala Gln 
            100                 105                 110         

Thr Asn Gly Ala Val Thr Ser Tyr Ile Asn Thr Ile Val Asn Ser Lys 
        115                 120                 125             

Ser Ile Thr Glu Ala Ile Ser Arg Val Ala Ala Met Ser Glu Ile Val 
    130                 135                 140                 

Ser Ala Asn Asn Lys Met Leu Glu Gln Gln Lys Ala Asp Lys Lys Ala 
145                 150                 155                 160 

Ile Ser Glu Lys Gln Val Ala Asn Asn Asp Ala Ile Asn Thr Val Ile 
                165                 170                 175     

Ala Asn Gln Gln Lys Leu Ala Asp Asp Ala Gln Ala Leu Thr Thr Lys 
            180                 185                 190         

Gln Ala Glu Leu Lys Ala Ala Glu Leu Ser Leu Ala Ala Glu Lys Ala 
        195                 200                 205             

Thr Ala Glu Gly Glu Lys Ala Ser Leu Leu Glu Gln Lys Ala Ala Ala 
    210                 215                 220                 

Glu Ala Glu Ala Arg Ala Ala Ala Val Ala Glu Ala Ala Tyr Lys Glu 
225                 230                 235                 240 

Lys Arg Ala Ser Gln Gln Gln Ser Val Leu Ala Ser Ala Asn Thr Asn 
                245                 250                 255     

Leu Thr Ala Gln Val Gln Ala Val Ser Glu Ser Ala Ala Ala Pro Val 
            260                 265                 270         

Arg Ala Lys Val Arg Pro Thr Tyr Ser Thr Asn Ala Ser Ser Tyr Pro 
        275                 280                 285             

Ile Gly Glu Cys Thr Trp Gly Val Lys Thr Leu Ala Pro Trp Ala Gly 
    290                 295                 300                 

Asp Tyr Trp Gly Asn Gly Ala Gln Trp Ala Thr Ser Ala Ala Ala Ala 
305                 310                 315                 320 

Gly Phe Arg Thr Gly Ser Thr Pro Gln Val Gly Ala Ile Ala Cys Trp 
                325                 330                 335     

Asn Asp Gly Gly Tyr Gly His Val Ala Val Val Thr Ala Val Glu Ser 
            340                 345                 350         

Thr Thr Arg Ile Gln Val Ser Glu Ser Asn Tyr Ala Gly Asn Arg Thr 
        355                 360                 365             

Ile Gly Asn His Arg Gly Trp Phe Asn Pro Thr Thr Thr Ser Glu Gly 
    370                 375                 380                 

Phe Val Thr Tyr Ile Tyr Ala Asp 
385                 390         

<210>   12
<211>   167
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   12
Met Lys Ser Ile Thr Lys Lys Ile Lys Ala Thr Leu Ala Gly Val Ala 
1               5                   10                  15      

Ala Leu Phe Ala Val Phe Ala Pro Ser Phe Val Ser Ala Gln Glu Ser 
            20                  25                  30          

Ser Thr Tyr Thr Val Lys Glu Gly Asp Thr Leu Ser Glu Ile Ala Glu 
        35                  40                  45              

Thr His Asn Thr Thr Val Glu Lys Leu Ala Glu Asn Asn His Ile Asp 
    50                  55                  60                  

Asn Ile His Leu Ile Tyr Val Asp Gln Glu Leu Val Ile Asp Gly Pro 
65                  70                  75                  80  

Val Ala Pro Val Ala Thr Pro Ala Pro Ala Thr Tyr Ala Ala Pro Ala 
                85                  90                  95      

Ala Gln Asp Glu Thr Val Ser Ala Pro Val Ala Glu Thr Pro Val Val 
            100                 105                 110         

Ser Glu Thr Val Val Ser Thr Val Ser Gly Ser Glu Ala Glu Ala Lys 
        115                 120                 125             

Glu Trp Ile Ala Gln Lys Glu Ser Gly Gly Ser Tyr Thr Ala Thr Asn 
    130                 135                 140                 

Gly Arg Tyr Ile Gly Arg Tyr Gly Ser Trp Thr Ala Ala Lys Asn Phe 
145                 150                 155                 160 

Trp Leu Asn Asn Gly Trp Tyr 
                165         

<210>   13
<211>   225
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   13
Met Thr Tyr Leu Asp Ala Phe Lys Ser Gly Thr Leu Val Leu Pro Ser 
1               5                   10                  15      

Ala Leu Leu Leu His Phe Lys Glu Leu Phe Pro Ser Ser Asp Asp Phe 
            20                  25                  30          

Leu Val Trp Gln Phe Phe Tyr Leu Gln Asn Thr Thr Gly Leu Glu Glu 
        35                  40                  45              

Met Ser Pro Ser Gln Ile Ala Glu Arg Ile Gly Lys Glu Ile Ser Asp 
    50                  55                  60                  

Val Asn Gln Ser Ile Ser Asn Leu Thr Glu Arg Gly Leu Leu Gln Tyr 
65                  70                  75                  80  

Arg Thr Ile Glu Leu Asn Gly Glu Ile Glu Leu Leu Phe Asp Ala Ser 
                85                  90                  95      

Leu Ala Leu Glu Arg Leu Asp Asp Leu Phe Gly Ala Val His Ser Ser 
            100                 105                 110         

Ser Asp Gln Leu Thr Ser Gln Asn Gln Leu Lys Asp Leu Val Glu Thr 
        115                 120                 125             

Phe Gln Gln Glu Leu Gly Arg Leu Leu Thr Pro Phe Glu Ile Glu Asp 
    130                 135                 140                 

Leu Thr Lys Thr Leu Lys Glu Asp Gly Thr Ser Ala Asp Leu Ile Lys 
145                 150                 155                 160 

Glu Ala Leu Arg Glu Ala Val Leu Asn Gly Lys Pro Asn Trp Lys Tyr 
                165                 170                 175     

Ile Gln Ala Ile Leu Arg Asn Trp Arg His Glu Gly Ile Lys Ser Val 
            180                 185                 190         

Ala Gln Ile Glu Ala Lys Arg Ala Glu Arg Glu Ala Ser Asn Pro Gln 
        195                 200                 205             

Leu Thr Gln Val Ser Ala Asp Phe Arg Asn Ala Met Asp Leu Trp Lys 
    210                 215                 220                 

Asp 
225 

<210>   14
<211>   659
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   14
Met Lys Lys Asn Arg Val Phe Ala Thr Ala Gly Leu Val Leu Leu Ala 
1               5                   10                  15      

Ala Gly Val Leu Ala Ala Cys Ser Ser Ser Lys Ser Ser Asp Ser Ser 
            20                  25                  30          

Ala Pro Lys Ala Tyr Gly Tyr Val Tyr Thr Ala Asp Pro Glu Thr Leu 
        35                  40                  45              

Asp Tyr Leu Ile Ser Arg Lys Asn Ser Thr Thr Val Val Thr Ser Asn 
    50                  55                  60                  

Gly Ile Asp Gly Leu Phe Thr Asn Asp Asn Tyr Gly Asn Leu Ala Pro 
65                  70                  75                  80  

Ala Val Ala Glu Asp Trp Glu Val Ser Lys Asp Gly Leu Thr Tyr Thr 
                85                  90                  95      

Tyr Lys Ile Arg Lys Gly Val Lys Trp Phe Thr Ser Asp Gly Glu Glu 
            100                 105                 110         

Tyr Ala Glu Val Thr Ala Lys Asp Phe Val Asn Gly Leu Lys His Ala 
        115                 120                 125             

Ala Asp Lys Lys Ser Glu Ala Met Tyr Leu Ala Glu Asn Ser Val Lys 
    130                 135                 140                 

Gly Leu Ala Asp Tyr Leu Ser Gly Thr Ser Thr Asp Phe Ser Thr Val 
145                 150                 155                 160 

Gly Val Lys Ala Val Asp Asp Tyr Thr Leu Gln Tyr Thr Leu Asn Gln 
                165                 170                 175     

Pro Glu Pro Phe Trp Asn Ser Lys Leu Thr Tyr Ser Ile Phe Trp Pro 
            180                 185                 190         

Leu Asn Glu Glu Phe Glu Thr Ser Lys Gly Ser Asp Phe Ala Lys Pro 
        195                 200                 205             

Thr Asp Pro Thr Ser Leu Leu Tyr Asn Gly Pro Phe Leu Leu Lys Gly 
    210                 215                 220                 

Leu Thr Ala Lys Ser Ser Val Glu Phe Val Lys Asn Glu Gln Tyr Trp 
225                 230                 235                 240 

Asp Lys Glu Asn Val His Leu Asp Thr Ile Asn Leu Ala Tyr Tyr Asp 
                245                 250                 255     

Gly Ser Asp Gln Glu Ser Leu Glu Arg Asn Phe Thr Ser Gly Ala Tyr 
            260                 265                 270         

Ser Tyr Ala Arg Leu Tyr Pro Thr Ser Ser Asn Tyr Ser Lys Val Ala 
        275                 280                 285             

Glu Glu Tyr Lys Asp Asn Ile Tyr Tyr Thr Gln Ser Gly Ser Gly Ile 
    290                 295                 300                 

Ala Gly Leu Gly Val Asn Ile Asp Arg Gln Ser Tyr Asn Tyr Thr Ser 
305                 310                 315                 320 

Lys Thr Thr Asp Ser Glu Lys Val Ala Thr Lys Lys Ala Leu Leu Asn 
                325                 330                 335     

Lys Asp Phe Arg Gln Ala Leu Asn Phe Ala Leu Asp Arg Ser Ala Tyr 
            340                 345                 350         

Ser Ala Gln Ile Asn Gly Lys Asp Gly Ala Ala Leu Ala Val Arg Asn 
        355                 360                 365             

Leu Phe Val Lys Pro Asp Phe Val Ser Ala Gly Glu Lys Thr Phe Gly 
    370                 375                 380                 

Asp Leu Val Ala Ala Gln Leu Pro Ala Tyr Gly Asp Glu Trp Lys Gly 
385                 390                 395                 400 

Val Asn Leu Ala Asp Gly Gln Asp Gly Leu Phe Asn Ala Asp Lys Ala 
                405                 410                 415     

Lys Ala Glu Phe Ala Lys Ala Lys Lys Ala Leu Glu Ala Asp Gly Val 
            420                 425                 430         

Gln Phe Pro Ile His Leu Asp Val Pro Val Asp Gln Ala Ser Lys Asn 
        435                 440                 445             

Tyr Ile Ser Arg Ile Gln Ser Phe Lys Gln Ser Val Glu Thr Val Leu 
    450                 455                 460                 

Gly Val Glu Asn Val Val Val Asp Ile Gln Gln Met Thr Ser Asp Glu 
465                 470                 475                 480 

Phe Leu Asn Ile Thr Tyr Tyr Ala Ala Asn Ala Ser Ser Glu Asp Trp 
                485                 490                 495     

Asp Val Ser Gly Gly Val Ser Trp Gly Pro Asp Tyr Gln Asp Pro Ser 
            500                 505                 510         

Thr Tyr Leu Asp Ile Leu Lys Thr Thr Ser Ser Glu Thr Thr Lys Thr 
        515                 520                 525             

Tyr Leu Gly Phe Asp Asn Pro Asn Ser Pro Ser Val Val Gln Val Gly 
    530                 535                 540                 

Leu Lys Glu Tyr Asp Lys Leu Val Asp Glu Ala Ala Lys Glu Thr Ser 
545                 550                 555                 560 

Asp Leu Asn Val Arg Tyr Glu Lys Tyr Ala Ala Ala Gln Ala Trp Leu 
                565                 570                 575     

Thr Asp Ser Ser Leu Phe Ile Pro Ala Met Ala Ser Ser Gly Ala Ala 
            580                 585                 590         

Pro Val Leu Ser Arg Ile Val Pro Phe Thr Gly Ala Ser Ala Gln Thr 
        595                 600                 605             

Gly Ser Lys Gly Ser Asp Val Tyr Phe Lys Tyr Leu Lys Leu Gln Asp 
    610                 615                 620                 

Lys Ala Val Thr Lys Glu Glu Tyr Glu Lys Ala Arg Glu Lys Trp Leu 
625                 630                 635                 640 

Lys Glu Lys Ala Glu Ser Asn Glu Lys Ala Gln Lys Glu Leu Ala Ser 
                645                 650                 655     

His Val Lys 
            

<210>   15
<211>   701
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   15
Met Phe Ala Ser Lys Ser Glu Arg Lys Val His Tyr Ser Ile Arg Lys 
1               5                   10                  15      

Phe Ser Ile Gly Val Ala Ser Val Ala Val Ala Ser Leu Val Met Gly 
            20                  25                  30          

Ser Val Val His Ala Thr Glu Asn Glu Gly Ser Thr Gln Ala Ala Thr 
        35                  40                  45              

Ser Ser Asn Met Ala Lys Thr Glu His Arg Lys Ala Ala Lys Gln Val 
    50                  55                  60                  

Val Asp Glu Tyr Ile Glu Lys Met Leu Arg Glu Ile Gln Leu Asp Arg 
65                  70                  75                  80  

Arg Lys His Thr Gln Asn Val Ala Leu Asn Ile Lys Leu Ser Ala Ile 
                85                  90                  95      

Lys Thr Lys Tyr Leu Arg Glu Leu Asn Val Leu Glu Glu Lys Ser Lys 
            100                 105                 110         

Asp Glu Leu Pro Ser Glu Ile Lys Ala Lys Leu Asp Ala Ala Phe Glu 
        115                 120                 125             

Lys Phe Lys Lys Asp Thr Leu Lys Pro Gly Glu Lys Val Ala Glu Ala 
    130                 135                 140                 

Lys Lys Lys Val Glu Glu Ala Lys Lys Lys Ala Glu Asp Gln Lys Glu 
145                 150                 155                 160 

Glu Asp Arg Arg Asn Tyr Pro Thr Asn Thr Tyr Lys Thr Leu Glu Leu 
                165                 170                 175     

Glu Ile Ala Glu Phe Asp Val Lys Val Lys Glu Ala Glu Leu Glu Leu 
            180                 185                 190         

Val Lys Glu Glu Ala Lys Glu Ser Arg Asn Glu Gly Thr Ile Lys Gln 
        195                 200                 205             

Ala Lys Glu Lys Val Glu Ser Lys Lys Ala Glu Ala Thr Arg Leu Glu 
    210                 215                 220                 

Asn Ile Lys Thr Asp Arg Lys Lys Ala Glu Glu Glu Ala Lys Arg Lys 
225                 230                 235                 240 

Ala Asp Ala Lys Leu Lys Glu Ala Asn Val Ala Thr Ser Asp Gln Gly 
                245                 250                 255     

Lys Pro Lys Gly Arg Ala Lys Arg Gly Val Pro Gly Glu Leu Ala Thr 
            260                 265                 270         

Pro Asp Lys Lys Glu Asn Asp Ala Lys Ser Ser Asp Ser Ser Val Gly 
        275                 280                 285             

Glu Glu Thr Leu Pro Ser Ser Ser Leu Lys Ser Gly Lys Lys Val Ala 
    290                 295                 300                 

Glu Ala Glu Lys Lys Val Glu Glu Ala Glu Lys Lys Ala Lys Asp Gln 
305                 310                 315                 320 

Lys Glu Glu Asp Arg Arg Asn Tyr Pro Thr Asn Thr Tyr Lys Thr Leu 
                325                 330                 335     

Asp Leu Glu Ile Ala Glu Ser Asp Val Lys Val Lys Glu Ala Glu Leu 
            340                 345                 350         

Glu Leu Val Lys Glu Glu Ala Lys Glu Pro Arg Asp Glu Glu Lys Ile 
        355                 360                 365             

Lys Gln Ala Lys Ala Lys Val Glu Ser Lys Lys Ala Glu Ala Thr Arg 
    370                 375                 380                 

Leu Glu Asn Ile Lys Thr Asp Arg Lys Lys Ala Glu Glu Glu Ala Lys 
385                 390                 395                 400 

Arg Lys Ala Ala Glu Glu Asp Lys Val Lys Glu Lys Pro Ala Glu Gln 
                405                 410                 415     

Pro Gln Pro Ala Pro Ala Thr Gln Pro Glu Lys Pro Ala Pro Lys Pro 
            420                 425                 430         

Glu Lys Pro Ala Glu Gln Pro Lys Ala Glu Lys Thr Asp Asp Gln Gln 
        435                 440                 445             

Ala Glu Glu Asp Tyr Ala Arg Arg Ser Glu Glu Glu Tyr Asn Arg Leu 
    450                 455                 460                 

Thr Gln Gln Gln Pro Pro Lys Thr Glu Lys Pro Ala Gln Pro Ser Thr 
465                 470                 475                 480 

Pro Lys Thr Gly Trp Lys Gln Glu Asn Gly Met Trp Tyr Phe Tyr Asn 
                485                 490                 495     

Thr Asp Gly Ser Met Ala Thr Gly Trp Leu Gln Asn Asn Gly Ser Trp 
            500                 505                 510         

Tyr Tyr Leu Asn Ala Asn Gly Ala Met Ala Thr Gly Trp Leu Gln Asn 
        515                 520                 525             

Asn Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Ser Met Ala Thr Gly 
    530                 535                 540                 

Trp Leu Gln Asn Asn Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Ala 
545                 550                 555                 560 

Met Ala Thr Gly Trp Leu Gln Tyr Asn Gly Ser Trp Tyr Tyr Leu Asn 
                565                 570                 575     

Ser Asn Gly Ala Met Ala Thr Gly Trp Leu Gln Tyr Asn Gly Ser Trp 
            580                 585                 590         

Tyr Tyr Leu Asn Ala Asn Gly Asp Met Ala Thr Gly Trp Leu Gln Asn 
        595                 600                 605             

Asn Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Asp Met Ala Thr Gly 
    610                 615                 620                 

Trp Leu Gln Tyr Asn Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Asp 
625                 630                 635                 640 

Met Ala Thr Gly Trp Val Lys Asp Gly Asp Thr Trp Tyr Tyr Leu Glu 
                645                 650                 655     

Ala Ser Gly Ala Met Lys Ala Ser Gln Trp Phe Lys Val Ser Asp Lys 
            660                 665                 670         

Trp Tyr Tyr Val Asn Gly Ser Gly Ala Leu Ala Val Asn Thr Thr Val 
        675                 680                 685             

Asp Gly Tyr Gly Val Asn Ala Asn Gly Glu Trp Val Asn 
    690                 695                 700     

<210>   16
<211>   196
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   16
Met Ile Pro Val Val Ile Glu Gln Thr Ser Arg Gly Glu Arg Ser Tyr 
1               5                   10                  15      

Asp Ile Tyr Ser Arg Leu Leu Lys Asp Arg Ile Ile Met Leu Thr Gly 
            20                  25                  30          

Pro Val Glu Asp Asn Met Ala Asn Ser Val Ile Ala Gln Leu Leu Phe 
        35                  40                  45              

Leu Asp Ala Gln Asp Ser Thr Lys Asp Ile Tyr Leu Tyr Val Asn Thr 
    50                  55                  60                  

Pro Gly Gly Ser Val Ser Ala Gly Leu Ala Ile Val Asp Thr Met Asn 
65                  70                  75                  80  

Phe Ile Lys Ala Asp Val Gln Thr Ile Val Met Gly Met Ala Ala Ser 
                85                  90                  95      

Met Gly Thr Val Ile Ala Ser Ser Gly Ala Lys Gly Lys Arg Phe Met 
            100                 105                 110         

Leu Pro Asn Ala Glu Tyr Met Ile His Gln Pro Met Gly Gly Thr Gly 
        115                 120                 125             

Gly Gly Thr Gln Gln Thr Asp Met Ala Ile Ala Ala Glu His Leu Leu 
    130                 135                 140                 

Lys Thr Arg Asn Thr Leu Glu Lys Ile Leu Ala Glu Asn Ser Gly Gln 
145                 150                 155                 160 

Ser Met Glu Lys Val His Ala Asp Ala Glu Arg Asp Asn Trp Met Ser 
                165                 170                 175     

Ala Gln Glu Thr Leu Glu Tyr Gly Phe Ile Asp Glu Ile Met Ala Asn 
            180                 185                 190         

Asn Ser Leu Asn 
        195     

<210>   17
<211>   318
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   17
Met Glu Ile Asn Val Ser Lys Leu Arg Thr Asp Leu Pro Gln Val Gly 
1               5                   10                  15      

Val Gln Pro Tyr Arg Gln Val His Ala His Ser Thr Gly Asn Pro His 
            20                  25                  30          

Ser Thr Val Gln Asn Glu Ala Asp Tyr His Trp Arg Lys Asp Pro Glu 
        35                  40                  45              

Leu Gly Phe Phe Ser His Ile Val Gly Asn Gly Cys Ile Met Gln Val 
    50                  55                  60                  

Gly Pro Val Asp Asn Gly Ala Trp Asp Val Gly Gly Gly Trp Asn Ala 
65                  70                  75                  80  

Glu Thr Tyr Ala Ala Val Glu Leu Ile Glu Ser His Ser Thr Lys Glu 
                85                  90                  95      

Glu Phe Met Thr Asp Tyr Arg Leu Tyr Ile Glu Leu Leu Arg Asn Leu 
            100                 105                 110         

Ala Asp Glu Ala Gly Leu Pro Lys Thr Leu Asp Thr Gly Ser Leu Ala 
        115                 120                 125             

Gly Ile Lys Thr His Glu Tyr Cys Thr Asn Asn Gln Pro Asn Asn His 
    130                 135                 140                 

Ser Asp His Val Asp Pro Tyr Pro Tyr Leu Ala Lys Trp Gly Ile Ser 
145                 150                 155                 160 

Arg Glu Gln Phe Lys His Asp Ile Glu Asn Gly Leu Thr Ile Glu Thr 
                165                 170                 175     

Gly Trp Gln Lys Asn Asp Thr Gly Tyr Trp Tyr Val His Ser Asp Gly 
            180                 185                 190         

Ser Tyr Pro Lys Asp Lys Phe Glu Lys Ile Asn Gly Thr Trp Tyr Tyr 
        195                 200                 205             

Phe Asp Ser Ser Gly Tyr Met Leu Ala Asp Arg Trp Arg Lys His Thr 
    210                 215                 220                 

Asp Gly Asn Trp Tyr Trp Phe Asp Asn Ser Gly Glu Met Ala Thr Gly 
225                 230                 235                 240 

Trp Lys Lys Ile Ala Asp Lys Trp Tyr Tyr Phe Asn Glu Glu Gly Ala 
                245                 250                 255     

Met Lys Thr Gly Trp Val Lys Tyr Lys Asp Thr Trp Tyr Tyr Leu Asp 
            260                 265                 270         

Ala Lys Glu Gly Ala Met Val Ser Asn Ala Phe Ile Gln Ser Ala Asp 
        275                 280                 285             

Gly Thr Gly Trp Tyr Tyr Leu Lys Pro Asp Gly Thr Leu Ala Asp Arg 
    290                 295                 300                 

Pro Glu Phe Thr Val Glu Pro Asp Gly Leu Ile Thr Val Lys 
305                 310                 315             

<210>   18
<211>   828
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   18
Met Gln Leu Glu Ile Ser Asn Arg Lys Arg Val Ser Met Lys Ile Asn 
1               5                   10                  15      

Lys Lys Tyr Leu Val Gly Ser Ala Ala Ala Leu Ile Leu Ser Val Cys 
            20                  25                  30          

Ser Tyr Glu Leu Gly Leu Tyr Gln Ala Arg Thr Val Lys Glu Asn Asn 
        35                  40                  45              

Arg Val Ser Tyr Ile Asp Gly Lys Gln Ala Thr Gln Lys Thr Glu Asn 
    50                  55                  60                  

Leu Thr Pro Asp Glu Val Ser Lys Arg Glu Gly Ile Asn Ala Glu Gln 
65                  70                  75                  80  

Ile Val Ile Lys Ile Thr Asp Gln Gly Tyr Val Thr Ser His Gly Asp 
                85                  90                  95      

His Tyr His Tyr Tyr Asn Gly Lys Val Pro Tyr Asp Ala Ile Phe Ser 
            100                 105                 110         

Glu Glu Leu Leu Met Lys Asp Pro Asn Tyr Lys Leu Lys Asp Glu Asp 
        115                 120                 125             

Ile Val Asn Glu Val Lys Gly Gly Tyr Val Ile Lys Val Asp Gly Lys 
    130                 135                 140                 

Tyr Tyr Val Tyr Leu Lys Asp Ala Ala His Ala Asp Asn Val Arg Thr 
145                 150                 155                 160 

Lys Glu Glu Ile Asn Arg Gln Lys Gln Glu His Ser Gln His Arg Glu 
                165                 170                 175     

Gly Gly Thr Pro Arg Asn Asp Gly Ala Val Ala Leu Ala Arg Ser Gln 
            180                 185                 190         

Gly Arg Tyr Thr Thr Asp Asp Gly Tyr Ile Phe Asn Ala Ser Asp Ile 
        195                 200                 205             

Ile Glu Asp Thr Gly Asp Ala Tyr Ile Val Pro His Gly Asp His Tyr 
    210                 215                 220                 

His Tyr Ile Pro Lys Asn Glu Leu Ser Ala Ser Glu Leu Ala Ala Ala 
225                 230                 235                 240 

Glu Ala Phe Leu Ser Gly Arg Gly Asn Leu Ser Asn Ser Arg Thr Tyr 
                245                 250                 255     

Arg Arg Gln Asn Ser Asp Asn Thr Ser Arg Thr Asn Trp Val Pro Ser 
            260                 265                 270         

Val Ser Asn Pro Gly Thr Thr Asn Thr Asn Thr Ser Asn Asn Ser Asn 
        275                 280                 285             

Thr Asn Ser Gln Ala Ser Gln Ser Asn Asp Ile Asp Ser Leu Leu Lys 
    290                 295                 300                 

Gln Leu Tyr Lys Leu Pro Leu Ser Gln Arg His Val Glu Ser Asp Gly 
305                 310                 315                 320 

Leu Val Phe Asp Pro Ala Gln Ile Thr Ser Arg Thr Ala Arg Gly Val 
                325                 330                 335     

Ala Val Pro His Gly Asp His Tyr His Phe Ile Pro Tyr Ser Gln Met 
            340                 345                 350         

Ser Glu Leu Glu Glu Arg Ile Ala Arg Ile Ile Pro Leu Arg Tyr Arg 
        355                 360                 365             

Ser Asn His Trp Val Pro Asp Ser Arg Pro Glu Gln Pro Ser Pro Gln 
    370                 375                 380                 

Pro Thr Pro Glu Pro Ser Pro Gly Pro Gln Pro Ala Pro Asn Leu Lys 
385                 390                 395                 400 

Ile Asp Ser Asn Ser Ser Leu Val Ser Gln Leu Val Arg Lys Val Gly 
                405                 410                 415     

Glu Gly Tyr Val Phe Glu Glu Lys Gly Ile Ser Arg Tyr Val Phe Ala 
            420                 425                 430         

Lys Asp Leu Pro Ser Glu Thr Val Lys Asn Leu Glu Ser Lys Leu Ser 
        435                 440                 445             

Lys Gln Glu Ser Val Ser His Thr Leu Thr Ala Lys Lys Glu Asn Val 
    450                 455                 460                 

Ala Pro Arg Asp Gln Glu Phe Tyr Asp Lys Ala Tyr Asn Leu Leu Thr 
465                 470                 475                 480 

Glu Ala His Lys Ala Leu Phe Glu Asn Lys Gly Arg Asn Ser Asp Phe 
                485                 490                 495     

Gln Ala Leu Asp Lys Leu Leu Glu Arg Leu Asn Asp Glu Ser Thr Asn 
            500                 505                 510         

Lys Glu Lys Leu Val Asp Asp Leu Leu Ala Phe Leu Ala Pro Ile Thr 
        515                 520                 525             

His Pro Glu Arg Leu Gly Lys Pro Asn Ser Gln Ile Glu Tyr Thr Glu 
    530                 535                 540                 

Asp Glu Val Arg Ile Ala Gln Leu Ala Asp Lys Tyr Thr Thr Ser Asp 
545                 550                 555                 560 

Gly Tyr Ile Phe Asp Glu His Asp Ile Ile Ser Asp Glu Gly Asp Ala 
                565                 570                 575     

Tyr Val Thr Pro His Met Gly His Ser His Trp Ile Gly Lys Asp Ser 
            580                 585                 590         

Leu Ser Asp Lys Glu Lys Val Ala Ala Gln Ala Tyr Thr Lys Glu Lys 
        595                 600                 605             

Gly Ile Leu Pro Pro Ser Pro Asp Ala Asp Val Lys Ala Asn Pro Thr 
    610                 615                 620                 

Gly Asp Ser Ala Ala Ala Ile Tyr Asn Arg Val Lys Gly Glu Lys Arg 
625                 630                 635                 640 

Ile Pro Leu Val Arg Leu Pro Tyr Met Val Glu His Thr Val Glu Val 
                645                 650                 655     

Lys Asn Gly Asn Leu Ile Ile Pro His Lys Asp His Tyr His Asn Ile 
            660                 665                 670         

Lys Phe Ala Trp Phe Asp Asp His Thr Tyr Lys Ala Pro Asn Gly Tyr 
        675                 680                 685             

Thr Leu Glu Asp Leu Phe Ala Thr Ile Lys Tyr Tyr Val Glu His Pro 
    690                 695                 700                 

Asp Glu Arg Pro His Ser Asn Asp Gly Trp Gly Asn Ala Ser Glu His 
705                 710                 715                 720 

Val Leu Gly Lys Lys Asp His Ser Glu Asp Pro Asn Lys Asn Phe Lys 
                725                 730                 735     

Ala Asp Glu Glu Pro Val Glu Glu Thr Pro Ala Glu Pro Glu Val Pro 
            740                 745                 750         

Gln Val Glu Thr Glu Lys Val Glu Ala Gln Leu Lys Glu Ala Glu Val 
        755                 760                 765             

Leu Leu Ala Lys Val Thr Asp Ser Ser Leu Lys Ala Asn Ala Thr Glu 
    770                 775                 780                 

Thr Leu Ala Gly Leu Arg Asn Asn Leu Thr Leu Gln Ile Met Asp Asn 
785                 790                 795                 800 

Asn Ser Ile Met Ala Glu Ala Glu Lys Leu Leu Ala Leu Leu Lys Gly 
                805                 810                 815     

Ser Asn Pro Ser Ser Val Ser Lys Glu Lys Ile Asn 
            820                 825             

<210>   19
<211>   819
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<221>   Xaa
<222>   578
<223>   Xaa is any amino acid e.g. K

<400>   19
Met Lys Ile Asn Lys Lys Tyr Leu Ala Gly Ser Val Ala Val Leu Ala 
1               5                   10                  15      

Leu Ser Val Cys Ser Tyr Glu Leu Gly Arg Tyr Gln Ala Gly Gln Asp 
            20                  25                  30          

Lys Lys Glu Ser Asn Arg Val Ala Tyr Ile Asp Gly Asp Gln Ala Gly 
        35                  40                  45              

Gln Lys Ala Glu Asn Leu Thr Pro Asp Glu Val Ser Lys Arg Glu Gly 
    50                  55                  60                  

Ile Asn Ala Glu Gln Ile Val Ile Lys Ile Thr Asp Gln Gly Tyr Val 
65                  70                  75                  80  

Thr Ser His Gly Asp His Tyr His Tyr Tyr Asn Gly Lys Val Pro Tyr 
                85                  90                  95      

Asp Ala Ile Ile Ser Glu Glu Leu Leu Met Lys Asp Pro Asn Tyr Gln 
            100                 105                 110         

Leu Lys Asp Ser Asp Ile Val Asn Glu Ile Lys Gly Gly Tyr Val Ile 
        115                 120                 125             

Lys Val Asn Gly Lys Tyr Tyr Val Tyr Leu Lys Asp Ala Ala His Ala 
    130                 135                 140                 

Asp Asn Ile Arg Thr Lys Glu Glu Ile Lys Arg Gln Lys Gln Glu Arg 
145                 150                 155                 160 

Ser His Asn His Asn Ser Arg Ala Asp Asn Ala Val Ala Ala Ala Arg 
                165                 170                 175     

Ala Gln Gly Arg Tyr Thr Thr Asp Asp Gly Tyr Ile Phe Asn Ala Ser 
            180                 185                 190         

Asp Ile Ile Glu Asp Thr Gly Asp Ala Tyr Ile Val Pro His Gly Asp 
        195                 200                 205             

His Tyr His Tyr Ile Pro Lys Asn Glu Leu Ser Ala Ser Glu Leu Ala 
    210                 215                 220                 

Ala Ala Glu Ala Tyr Trp Asn Gly Lys Gln Gly Ser Arg Pro Ser Ser 
225                 230                 235                 240 

Ser Ser Ser Tyr Asn Ala Asn Pro Ala Gln Pro Arg Leu Ser Glu Asn 
                245                 250                 255     

His Asn Leu Thr Val Thr Pro Thr Tyr His Gln Asn Gln Gly Glu Asn 
            260                 265                 270         

Ile Ser Ser Leu Leu Arg Glu Leu Tyr Ala Lys Pro Leu Ser Glu Arg 
        275                 280                 285             

His Val Glu Ser Asp Gly Leu Ile Phe Asp Pro Ala Gln Ile Thr Ser 
    290                 295                 300                 

Arg Thr Ala Arg Gly Val Ala Val Pro His Gly Asn His Tyr His Phe 
305                 310                 315                 320 

Ile Pro Tyr Glu Gln Met Ser Glu Leu Glu Lys Arg Ile Ala Arg Ile 
                325                 330                 335     

Ile Pro Leu Arg Tyr Arg Ser Asn His Trp Val Pro Asp Ser Arg Pro 
            340                 345                 350         

Glu Glu Pro Ser Pro Gln Pro Thr Pro Glu Pro Ser Pro Ser Pro Gln 
        355                 360                 365             

Pro Ala Pro Ser Asn Pro Ile Asp Gly Lys Leu Val Lys Glu Ala Val 
    370                 375                 380                 

Arg Lys Val Gly Asp Gly Tyr Val Phe Glu Glu Asn Gly Val Ser Arg 
385                 390                 395                 400 

Tyr Ile Pro Ala Lys Asp Leu Ser Ala Glu Thr Ala Ala Gly Ile Asp 
                405                 410                 415     

Ser Lys Leu Ala Lys Gln Glu Ser Leu Ser His Lys Leu Gly Thr Lys 
            420                 425                 430         

Lys Thr Asp Leu Pro Ser Ser Asp Arg Glu Phe Tyr Asn Lys Ala Tyr 
        435                 440                 445             

Asp Leu Leu Ala Arg Ile His Gln Asp Leu Leu Asp Asn Lys Gly Arg 
    450                 455                 460                 

Gln Val Asp Phe Glu Ala Leu Asp Asn Leu Leu Glu Arg Leu Lys Asp 
465                 470                 475                 480 

Val Ser Ser Asp Lys Val Lys Leu Val Glu Asp Ile Leu Ala Phe Leu 
                485                 490                 495     

Ala Pro Ile Arg His Pro Glu Arg Leu Gly Lys Pro Asn Ala Gln Ile 
            500                 505                 510         

Thr Tyr Thr Asp Asp Glu Ile Gln Val Ala Lys Leu Ala Gly Lys Tyr 
        515                 520                 525             

Thr Ala Glu Asp Gly Tyr Ile Phe Asp Pro Arg Asp Ile Thr Ser Asp 
    530                 535                 540                 

Glu Gly Asp Ala Tyr Val Thr Pro His Met Thr His Ser His Trp Ile 
545                 550                 555                 560 

Lys Lys Asp Ser Leu Ser Glu Ala Glu Arg Ala Ala Ala Gln Ala Tyr 
                565                 570                 575     

Ala Xaa Glu Lys Gly Leu Thr Pro Pro Ser Thr Asp His Gln Asp Ser 
            580                 585                 590         

Gly Asn Thr Glu Ala Lys Gly Ala Glu Ala Ile Tyr Asn Arg Val Lys 
        595                 600                 605             

Ala Ala Lys Lys Val Pro Leu Asp Arg Met Pro Tyr Asn Leu Gln Tyr 
    610                 615                 620                 

Thr Val Glu Val Lys Asn Gly Ser Leu Ile Ile Pro His Tyr Asp His 
625                 630                 635                 640 

Tyr His Asn Ile Lys Phe Glu Trp Phe Asp Glu Gly Leu Tyr Glu Ala 
                645                 650                 655     

Pro Lys Gly Tyr Thr Leu Glu Asp Leu Leu Ala Thr Val Lys Tyr Tyr 
            660                 665                 670         

Val Glu His Pro Asn Glu Arg Pro His Ser Asp Asn Gly Phe Gly Asn 
        675                 680                 685             

Ala Ser Asp His Val Gln Arg Asn Lys Asn Gly Gln Ala Asp Thr Asn 
    690                 695                 700                 

Gln Thr Glu Lys Pro Ser Glu Glu Lys Pro Gln Thr Glu Lys Pro Glu 
705                 710                 715                 720 

Glu Glu Thr Pro Arg Glu Glu Lys Pro Gln Ser Glu Lys Pro Glu Ser 
                725                 730                 735     

Pro Lys Pro Thr Glu Glu Pro Glu Glu Ser Pro Glu Glu Ser Glu Glu 
            740                 745                 750         

Pro Gln Val Glu Thr Glu Lys Val Glu Glu Lys Leu Arg Glu Ala Glu 
        755                 760                 765             

Asp Leu Leu Gly Lys Ile Gln Asp Pro Ile Ile Lys Ser Asn Ala Lys 
    770                 775                 780                 

Glu Thr Leu Thr Gly Leu Lys Asn Asn Leu Leu Phe Gly Thr Gln Asp 
785                 790                 795                 800 

Asn Asn Thr Ile Met Ala Glu Ala Glu Lys Leu Leu Ala Leu Leu Lys 
                805                 810                 815     

Glu Ser Lys 
            

<210>   20
<211>   853
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   20
Met Lys Ile Asn Lys Lys Tyr Leu Ala Gly Ser Val Ala Val Leu Ala 
1               5                   10                  15      

Leu Ser Val Cys Ser Tyr Glu Leu Gly Arg His Gln Ala Gly Gln Val 
            20                  25                  30          

Lys Lys Glu Ser Asn Arg Val Ser Tyr Ile Asp Gly Asp Gln Ala Gly 
        35                  40                  45              

Gln Lys Ala Glu Asn Leu Thr Pro Asp Glu Val Ser Lys Arg Glu Gly 
    50                  55                  60                  

Ile Asn Ala Glu Gln Ile Val Ile Lys Ile Thr Asp Gln Gly Tyr Val 
65                  70                  75                  80  

Thr Ser His Gly Asp His Tyr His Tyr Tyr Asn Gly Lys Val Pro Tyr 
                85                  90                  95      

Asp Ala Ile Ile Ser Glu Glu Leu Leu Met Lys Asp Pro Asn Tyr Gln 
            100                 105                 110         

Leu Lys Asp Ser Asp Ile Val Asn Glu Ile Lys Gly Gly Tyr Val Ile 
        115                 120                 125             

Lys Val Asp Gly Lys Tyr Tyr Val Tyr Leu Lys Asp Ala Ala His Ala 
    130                 135                 140                 

Asp Asn Ile Arg Thr Lys Glu Glu Ile Lys Arg Gln Lys Gln Glu Arg 
145                 150                 155                 160 

Ser His Asn His Asn Ser Arg Ala Asp Asn Ala Val Ala Ala Ala Arg 
                165                 170                 175     

Ala Gln Gly Arg Tyr Thr Thr Asp Asp Gly Tyr Ile Phe Asn Ala Ser 
            180                 185                 190         

Asp Ile Ile Glu Asp Thr Gly Asp Ala Tyr Ile Val Pro His Gly Asp 
        195                 200                 205             

His Tyr His Tyr Ile Pro Lys Ser Asp Leu Ser Ala Ser Glu Leu Ala 
    210                 215                 220                 

Ala Ala Gln Ala Tyr Trp Asn Gly Lys Gln Gly Ser Arg Pro Ser Ser 
225                 230                 235                 240 

Ser Ser Ser His Asn Ala Asn Pro Ala Gln Pro Arg Leu Ser Glu Asn 
                245                 250                 255     

His Asn Leu Thr Val Thr Pro Thr Tyr His Gln Asn Gln Gly Glu Asn 
            260                 265                 270         

Ile Ser Ser Leu Leu Arg Glu Leu Tyr Ala Lys Pro Leu Ser Glu Arg 
        275                 280                 285             

His Val Glu Ser Asp Gly Leu Ile Phe Asp Pro Ala Gln Ile Thr Ser 
    290                 295                 300                 

Arg Thr Ala Asn Gly Val Ala Val Pro His Gly Asp His Tyr His Phe 
305                 310                 315                 320 

Ile Pro Tyr Ser Gln Leu Ser Pro Leu Glu Glu Lys Leu Ala Arg Ile 
                325                 330                 335     

Ile Pro Leu Arg Tyr Arg Ser Asn His Trp Val Pro Asp Ser Arg Pro 
            340                 345                 350         

Glu Gln Pro Ser Pro Gln Ser Thr Pro Glu Pro Ser Pro Ser Pro Gln 
        355                 360                 365             

Pro Ala Pro Asn Pro Gln Pro Ala Pro Ser Asn Pro Ile Asp Glu Lys 
    370                 375                 380                 

Leu Val Lys Glu Ala Val Arg Lys Val Gly Asp Gly Tyr Val Phe Glu 
385                 390                 395                 400 

Glu Asn Gly Val Pro Arg Tyr Ile Pro Ala Lys Asp Leu Ser Ala Glu 
                405                 410                 415     

Thr Ala Ala Gly Ile Asp Ser Lys Leu Ala Lys Gln Glu Ser Leu Ser 
            420                 425                 430         

His Lys Leu Gly Ala Lys Lys Thr Asp Leu Pro Ser Ser Asp Arg Glu 
        435                 440                 445             

Phe Tyr Asn Lys Ala Tyr Asp Leu Leu Ala Arg Ile His Gln Asp Leu 
    450                 455                 460                 

Leu Asp Asn Lys Gly Arg Gln Val Asp Phe Glu Ala Leu Asp Asn Leu 
465                 470                 475                 480 

Leu Glu Arg Leu Lys Asp Val Ser Ser Asp Lys Val Lys Leu Val Asp 
                485                 490                 495     

Asp Ile Leu Ala Phe Leu Ala Pro Ile Arg His Pro Glu Arg Leu Gly 
            500                 505                 510         

Lys Pro Asn Ala Gln Ile Thr Tyr Thr Asp Asp Glu Ile Gln Val Ala 
        515                 520                 525             

Lys Leu Ala Gly Lys Tyr Thr Thr Glu Asp Gly Tyr Ile Phe Asp Pro 
    530                 535                 540                 

Arg Asp Ile Thr Ser Asp Glu Gly Asp Ala Tyr Val Thr Pro His Met 
545                 550                 555                 560 

Thr His Ser His Trp Ile Lys Lys Asp Ser Leu Ser Glu Ala Glu Arg 
                565                 570                 575     

Ala Ala Ala Gln Ala Tyr Ala Lys Glu Lys Gly Leu Thr Pro Pro Ser 
            580                 585                 590         

Thr Asp His Gln Asp Ser Gly Asn Thr Glu Ala Lys Gly Ala Glu Ala 
        595                 600                 605             

Ile Tyr Asn Arg Val Lys Ala Ala Lys Lys Val Pro Leu Asp Arg Met 
    610                 615                 620                 

Pro Tyr Asn Leu Gln Tyr Thr Val Glu Val Lys Asn Gly Ser Leu Ile 
625                 630                 635                 640 

Ile Pro His Tyr Asp His Tyr His Asn Ile Lys Phe Glu Trp Phe Asp 
                645                 650                 655     

Glu Gly Leu Tyr Glu Ala Pro Lys Gly Tyr Ser Leu Glu Asp Leu Leu 
            660                 665                 670         

Ala Thr Val Lys Tyr Tyr Val Glu His Pro Asn Glu Arg Pro His Ser 
        675                 680                 685             

Asp Asn Gly Phe Gly Asn Ala Ser Asp His Val Gln Arg Asn Lys Asn 
    690                 695                 700                 

Gly Gln Ala Asp Thr Asn Gln Thr Glu Lys Pro Asn Glu Glu Lys Pro 
705                 710                 715                 720 

Gln Thr Glu Lys Pro Glu Glu Asp Lys Glu His Asp Glu Val Ser Glu 
                725                 730                 735     

Pro Thr His Pro Glu Ser Asp Glu Lys Glu Asn His Val Gly Leu Asn 
            740                 745                 750         

Pro Ser Ala Asp Asn Leu Tyr Lys Pro Ser Thr Asp Thr Glu Glu Thr 
        755                 760                 765             

Glu Glu Glu Ala Glu Asp Thr Thr Asp Glu Ala Glu Ile Pro Gln Val 
    770                 775                 780                 

Glu His Ser Val Ile Asn Ala Lys Ile Ala Glu Ala Glu Ala Leu Leu 
785                 790                 795                 800 

Glu Lys Val Thr Asp Ser Ser Ile Arg Gln Asn Ala Val Glu Thr Leu 
                805                 810                 815     

Thr Gly Leu Lys Ser Ser Leu Leu Leu Gly Thr Lys Asp Asn Asn Thr 
            820                 825                 830         

Ile Ser Ala Glu Val Asp Ser Leu Leu Ala Leu Leu Lys Glu Ser Gln 
        835                 840                 845             

Pro Thr Pro Ile Gln 
    850             

<210>   21
<211>   1039
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   21
Met Lys Phe Ser Lys Lys Tyr Ile Ala Ala Gly Ser Ala Val Ile Val 
1               5                   10                  15      

Ser Leu Ser Leu Cys Ala Tyr Ala Leu Asn Gln His Arg Ser Gln Glu 
            20                  25                  30          

Asn Lys Asp Asn Asn Arg Val Ser Tyr Val Asp Gly Ser Gln Ser Ser 
        35                  40                  45              

Gln Lys Ser Glu Asn Leu Thr Pro Asp Gln Val Ser Gln Lys Glu Gly 
    50                  55                  60                  

Ile Gln Ala Glu Gln Ile Val Ile Lys Ile Thr Asp Gln Gly Tyr Val 
65                  70                  75                  80  

Thr Ser His Gly Asp His Tyr His Tyr Tyr Asn Gly Lys Val Pro Tyr 
                85                  90                  95      

Asp Ala Leu Phe Ser Glu Glu Leu Leu Met Lys Asp Pro Asn Tyr Gln 
            100                 105                 110         

Leu Lys Asp Ala Asp Ile Val Asn Glu Val Lys Gly Gly Tyr Ile Ile 
        115                 120                 125             

Lys Val Asp Gly Lys Tyr Tyr Val Tyr Leu Lys Asp Ala Ala His Ala 
    130                 135                 140                 

Asp Asn Val Arg Thr Lys Asp Glu Ile Asn Arg Gln Lys Gln Glu His 
145                 150                 155                 160 

Val Lys Asp Asn Glu Lys Val Asn Ser Asn Val Ala Val Ala Arg Ser 
                165                 170                 175     

Gln Gly Arg Tyr Thr Thr Asn Asp Gly Tyr Val Phe Asn Pro Ala Asp 
            180                 185                 190         

Ile Ile Glu Asp Thr Gly Asn Ala Tyr Ile Val Pro His Gly Gly His 
        195                 200                 205             

Tyr His Tyr Ile Pro Lys Ser Asp Leu Ser Ala Ser Glu Leu Ala Ala 
    210                 215                 220                 

Ala Lys Ala His Leu Ala Gly Lys Asn Met Gln Pro Ser Gln Leu Ser 
225                 230                 235                 240 

Tyr Ser Ser Thr Ala Ser Asp Asn Asn Thr Gln Ser Val Ala Lys Gly 
                245                 250                 255     

Ser Thr Ser Lys Pro Ala Asn Lys Ser Glu Asn Leu Gln Ser Leu Leu 
            260                 265                 270         

Lys Glu Leu Tyr Asp Ser Pro Ser Ala Gln Arg Tyr Ser Glu Ser Asp 
        275                 280                 285             

Gly Leu Val Phe Asp Pro Ala Lys Ile Ile Ser Arg Thr Pro Asn Gly 
    290                 295                 300                 

Val Ala Ile Pro His Gly Asp His Tyr His Phe Ile Pro Tyr Ser Lys 
305                 310                 315                 320 

Leu Ser Ala Leu Glu Glu Lys Ile Ala Arg Arg Val Pro Ile Ser Gly 
                325                 330                 335     

Thr Gly Ser Thr Val Ser Thr Asn Ala Lys Pro Asn Glu Val Val Ser 
            340                 345                 350         

Ser Leu Gly Ser Leu Ser Ser Asn Pro Ser Ser Leu Thr Thr Ser Lys 
        355                 360                 365             

Glu Leu Ser Ser Ala Ser Asp Gly Tyr Ile Phe Asn Pro Lys Asp Ile 
    370                 375                 380                 

Val Glu Glu Thr Ala Thr Ala Tyr Ile Val Arg His Gly Asp His Phe 
385                 390                 395                 400 

His Tyr Ile Pro Lys Ser Asn Gln Ile Gly Gln Pro Thr Leu Pro Asn 
                405                 410                 415     

Asn Ser Leu Ala Thr Pro Ser Pro Ser Leu Pro Ile Asn Pro Gly Ile 
            420                 425                 430         

Ser His Glu Lys His Glu Glu Asp Gly Tyr Gly Phe Asp Ala Asn Arg 
        435                 440                 445             

Ile Ile Ala Glu Asp Glu Ser Gly Phe Ile Met Ser His Gly Asn His 
    450                 455                 460                 

Asn His Tyr Phe Phe Lys Lys Asp Leu Thr Glu Glu Gln Ile Lys Ala 
465                 470                 475                 480 

Ala Gln Lys His Leu Glu Glu Val Lys Thr Ser His Asn Gly Leu Asp 
                485                 490                 495     

Ser Leu Ser Ser His Glu Gln Asp Tyr Pro Gly Asn Ala Lys Glu Met 
            500                 505                 510         

Lys Asp Leu Asp Lys Lys Ile Glu Glu Lys Ile Ala Gly Ile Met Lys 
        515                 520                 525             

Gln Tyr Gly Val Lys Arg Glu Ser Ile Val Val Asn Lys Glu Lys Asn 
    530                 535                 540                 

Ala Ile Ile Tyr Pro His Gly Asp His His His Ala Asp Pro Ile Asp 
545                 550                 555                 560 

Glu His Lys Pro Val Gly Ile Gly His Ser His Ser Asn Tyr Glu Leu 
                565                 570                 575     

Phe Lys Pro Glu Glu Gly Val Ala Lys Lys Glu Gly Asn Lys Val Tyr 
            580                 585                 590         

Thr Gly Glu Glu Leu Thr Asn Val Val Asn Leu Leu Lys Asn Ser Thr 
        595                 600                 605             

Phe Asn Asn Gln Asn Phe Thr Leu Ala Asn Gly Gln Lys Arg Val Ser 
    610                 615                 620                 

Phe Ser Phe Pro Pro Glu Leu Glu Lys Lys Leu Gly Ile Asn Met Leu 
625                 630                 635                 640 

Val Lys Leu Ile Thr Pro Asp Gly Lys Val Leu Glu Lys Val Ser Gly 
                645                 650                 655     

Lys Val Phe Gly Glu Gly Val Gly Asn Ile Ala Asn Phe Glu Leu Asp 
            660                 665                 670         

Gln Pro Tyr Leu Pro Gly Gln Thr Phe Lys Tyr Thr Ile Ala Ser Lys 
        675                 680                 685             

Asp Tyr Pro Glu Val Ser Tyr Asp Gly Thr Phe Thr Val Pro Thr Ser 
    690                 695                 700                 

Leu Ala Tyr Lys Met Ala Ser Gln Thr Ile Phe Tyr Pro Phe His Ala 
705                 710                 715                 720 

Gly Asp Thr Tyr Leu Arg Val Asn Pro Gln Phe Ala Val Pro Lys Gly 
                725                 730                 735     

Thr Asp Ala Leu Val Arg Val Phe Asp Glu Phe His Gly Asn Ala Tyr 
            740                 745                 750         

Leu Glu Asn Asn Tyr Lys Val Gly Glu Ile Lys Leu Pro Ile Pro Lys 
        755                 760                 765             

Leu Asn Gln Gly Thr Thr Arg Thr Ala Gly Asn Lys Ile Pro Val Thr 
    770                 775                 780                 

Phe Met Ala Asn Ala Tyr Leu Asp Asn Gln Ser Thr Tyr Ile Val Glu 
785                 790                 795                 800 

Val Pro Ile Leu Glu Lys Glu Asn Gln Thr Asp Lys Pro Ser Ile Leu 
                805                 810                 815     

Pro Gln Phe Lys Arg Asn Lys Ala Gln Glu Asn Ser Lys Leu Asp Glu 
            820                 825                 830         

Lys Val Glu Glu Pro Lys Thr Ser Glu Lys Val Glu Lys Glu Lys Leu 
        835                 840                 845             

Ser Glu Thr Gly Asn Ser Thr Ser Asn Ser Thr Leu Glu Glu Val Pro 
    850                 855                 860                 

Thr Val Asp Pro Val Gln Glu Lys Val Ala Lys Phe Ala Glu Ser Tyr 
865                 870                 875                 880 

Gly Met Lys Leu Glu Asn Val Leu Phe Asn Met Asp Gly Thr Ile Glu 
                885                 890                 895     

Leu Tyr Leu Pro Ser Gly Glu Val Ile Lys Lys Asn Met Ala Asp Phe 
            900                 905                 910         

Thr Gly Glu Ala Pro Gln Gly Asn Gly Glu Asn Lys Pro Ser Glu Asn 
        915                 920                 925             

Gly Lys Val Ser Thr Gly Thr Val Glu Asn Gln Pro Thr Glu Asn Lys 
    930                 935                 940                 

Pro Ala Asp Ser Leu Pro Glu Ala Pro Asn Glu Lys Pro Val Lys Pro 
945                 950                 955                 960 

Glu Asn Ser Thr Asp Asn Gly Met Leu Asn Pro Glu Gly Asn Val Gly 
                965                 970                 975     

Ser Asp Pro Met Leu Asp Pro Ala Leu Glu Glu Ala Pro Ala Val Asp 
            980                 985                 990         

Pro Val Gln Glu Lys Leu Glu Lys Phe Thr Ala Ser Tyr Gly Leu Gly 
        995                 1000                1005            

Leu Asp Ser Val Ile Phe Asn Met Asp Gly Thr Ile Glu Leu Arg Leu 
    1010                1015                1020                

Pro Ser Gly Glu Val Ile Lys Lys Asn Leu Ser Asp Leu Ile Ala 
1025                1030                1035                

<210>   22
<211>   1876
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   22
Met Phe Lys Lys Asp Arg Phe Ser Ile Arg Lys Ile Lys Gly Val Val 
1               5                   10                  15      

Gly Ser Val Phe Leu Gly Ser Leu Leu Met Ala Pro Ser Val Val Asp 
            20                  25                  30          

Ala Ala Thr Tyr His Tyr Val Asn Lys Glu Ile Ile Ser Gln Glu Ala 
        35                  40                  45              

Lys Asp Leu Ile Gln Thr Gly Lys Pro Asp Arg Asn Glu Val Val Tyr 
    50                  55                  60                  

Gly Leu Val Tyr Gln Lys Asp Gln Leu Pro Gln Thr Gly Thr Glu Ala 
65                  70                  75                  80  

Ser Val Leu Thr Ala Phe Gly Leu Leu Thr Val Gly Ser Leu Leu Leu 
                85                  90                  95      

Ile Tyr Lys Arg Lys Lys Ile Ala Ser Val Phe Leu Val Gly Thr Met 
            100                 105                 110         

Gly Leu Val Val Leu Pro Ser Ala Gly Ala Val Asp Pro Val Ala Thr 
        115                 120                 125             

Leu Ala Leu Ala Ser Arg Glu Gly Val Val Glu Met Glu Gly Tyr Arg 
    130                 135                 140                 

Tyr Val Gly Tyr Leu Ser Gly Asp Ile Leu Lys Thr Leu Gly Leu Asp 
145                 150                 155                 160 

Thr Val Leu Glu Glu Thr Ser Ala Lys Pro Gly Glu Val Thr Val Val 
                165                 170                 175     

Glu Val Glu Thr Pro Gln Ser Thr Thr Asn Gln Glu Gln Ala Arg Thr 
            180                 185                 190         

Glu Asn Gln Val Val Glu Thr Glu Glu Ala Pro Lys Glu Glu Ala Pro 
        195                 200                 205             

Lys Thr Glu Glu Ser Pro Lys Glu Glu Pro Lys Ser Glu Val Lys Pro 
    210                 215                 220                 

Thr Asp Asp Thr Leu Pro Lys Val Glu Glu Gly Lys Glu Asp Ser Ala 
225                 230                 235                 240 

Glu Pro Ala Pro Val Glu Glu Val Gly Gly Glu Val Glu Ser Lys Pro 
                245                 250                 255     

Glu Glu Lys Val Ala Val Lys Pro Glu Ser Gln Pro Ser Asp Lys Pro 
            260                 265                 270         

Ala Glu Glu Ser Lys Val Glu Gln Ala Gly Glu Pro Val Ala Pro Arg 
        275                 280                 285             

Lys Asp Glu Gln Ala Pro Val Glu Pro Glu Asn Gln Pro Glu Ala Pro 
    290                 295                 300                 

Glu Glu Glu Lys Ala Val Glu Glu Thr Pro Lys Gln Glu Glu Ser Thr 
305                 310                 315                 320 

Pro Asp Thr Lys Ala Glu Glu Thr Val Glu Pro Lys Glu Glu Thr Lys 
                325                 330                 335     

Thr Ala Lys Gly Thr Gln Glu Glu Gly Lys Glu Gly Gln Ala Pro Val 
            340                 345                 350         

Gln Glu Val Asn Pro Glu Tyr Lys Val Thr Thr Gly Thr Val Glu Lys 
        355                 360                 365             

Ser Thr Glu Ser Glu Leu Asp Phe Thr Thr Glu Val Val Pro Asp Asp 
    370                 375                 380                 

Thr Lys Tyr Val Asp Glu Glu Val Val Glu Arg Gln Gly Ser Lys Gly 
385                 390                 395                 400 

Val Gln Val Thr Lys Thr Thr Tyr Glu Thr Val Glu Val Val Glu Thr 
                405                 410                 415     

Asp Lys Val Leu Ser Thr Thr Thr Glu Val Lys Thr Pro Val Val Pro 
            420                 425                 430         

Lys Val Val Lys Lys Gly Thr Lys Pro Val Glu Thr Arg Glu Glu Val 
        435                 440                 445             

Ile Pro Phe Ala Thr Lys Glu Gln Glu Asp Asp Thr Leu Lys Arg Gly 
    450                 455                 460                 

Thr Arg Gln Val Ala Gln Glu Gly Val Asn Gly Lys Lys Gln Ile Thr 
465                 470                 475                 480 

Glu Thr Tyr Lys Thr Ile Arg Gly Glu Lys Thr Asn Glu Ala Pro Thr 
                485                 490                 495     

Val Glu Glu Thr Val Leu Gln Ala Pro Gln Asp Glu Ile Ile Lys Lys 
            500                 505                 510         

Gly Thr Lys Gly Leu Glu Lys Pro Thr Leu Gln Trp Ala Asn Thr Glu 
        515                 520                 525             

Lys Asp Val Leu Lys Lys Ser Ala Thr Ala Ser Tyr Thr Leu Thr Lys 
    530                 535                 540                 

Pro Ala Gly Val Glu Ile Lys Ser Ile Lys Leu Ala Leu Lys Asp Lys 
545                 550                 555                 560 

Asp Gly Gln Leu Val Lys Glu Val Thr Val Ala Glu Asn Asn Leu Asn 
                565                 570                 575     

Ala Thr Leu Asp Lys Leu Lys Tyr Tyr Gln Gly Tyr Thr Leu Ser Thr 
            580                 585                 590         

Thr Met Val Tyr Asp Arg Gly Glu Gly Glu Glu Thr Glu Lys Leu Glu 
        595                 600                 605             

Asp Lys Gln Ile Gln Leu Asp Leu Lys Lys Val Glu Ile Lys Asn Ile 
    610                 615                 620                 

Lys Glu Thr Ser Leu Met Asn Val Asp Ala Glu Gly Asn Glu Thr Asp 
625                 630                 635                 640 

Lys Ser Leu Leu Ser Glu Lys Pro Thr Asp Val Ser Gln Leu Tyr Leu 
                645                 650                 655     

Arg Val Thr Thr His Asp Asn Lys Val Thr Arg Leu Ala Val Ser Ser 
            660                 665                 670         

Val Glu Glu Val Val Val Asp Gly Lys Thr Leu Tyr Lys Val Val Ala 
        675                 680                 685             

Lys Ala Pro Asp Leu Val Gln Arg Arg Ala Asp Asp Thr Leu Ser Glu 
    690                 695                 700                 

Glu Tyr Val His Tyr Phe Glu Lys Gln Leu Pro Lys Val Asn Asn Val 
705                 710                 715                 720 

Tyr Tyr Asn Phe Asn Glu Leu Val Lys Asp Met Gln Ala Asn Pro Met 
                725                 730                 735     

Gly Glu Phe Lys Leu Gly Ala Asp Leu Asn Ala Val Asn Val Lys Pro 
            740                 745                 750         

Ala Gly Lys Ala Tyr Val Met Ala Lys Phe Arg Gly Thr Leu Ser Ser 
        755                 760                 765             

Val Glu Asn His Gln Tyr Thr Ile His Asn Leu Glu Arg Pro Leu Phe 
    770                 775                 780                 

Asn Glu Ala Glu Gly Ala Thr Leu Lys Asn Phe Asn Leu Gly Asn Val 
785                 790                 795                 800 

Asn Ile Asn Met Pro Trp Ala Asp Lys Val Ala Pro Ile Gly Asn Met 
                805                 810                 815     

Phe Lys Lys Ser Thr Leu Glu Asn Ile Lys Val Val Gly Ser Val Thr 
            820                 825                 830         

Gly Asn Asn Asp Val Thr Gly Ala Val Asn Lys Leu Asp Glu Ala Asn 
        835                 840                 845             

Met Arg Asn Val Ala Phe Ile Gly Lys Ile Asn Ser Leu Gly Asp Lys 
    850                 855                 860                 

Gly Trp Trp Ser Gly Gly Leu Val Ser Glu Ser Trp Arg Ser Asn Thr 
865                 870                 875                 880 

Asp Ser Val Tyr Phe Asp Gly Asp Ile Val Gly Asn Asn Ser Lys Phe 
                885                 890                 895     

Gly Gly Leu Val Ala Lys Val Asn His Gly Ser Asn Gln Trp Asp Val 
            900                 905                 910         

Lys Gln Lys Gly Arg Leu Thr Asn Ser Val Val Lys Gly Thr Met Thr 
        915                 920                 925             

Leu Lys Asn His Gly Gln Ser Gly Gly Leu Val His Glu Asn Tyr Asp 
    930                 935                 940                 

Trp Gly Trp Val Glu Asn Asn Ile Ser Met Met Lys Val Asn Asn Gly 
945                 950                 955                 960 

Glu Ile Met Tyr Gly Ser Gly Ser Ile Asp Gly Asp Pro Tyr Phe Gly 
                965                 970                 975     

Phe Asp Tyr Phe Lys Asn Asn Tyr Tyr Val Lys Asp Val Ala Thr Gly 
            980                 985                 990         

Glu Ser Thr Tyr Lys Arg Ser Lys Gln Ile Gln Ser Ile Ser Gln Ala 
        995                 1000                1005            

Glu Ala Asp Ala Lys Ile Ala Asn Met Gly Ile Thr Ala Asn Thr Phe 
    1010                1015                1020                

Ala Ile Gln Asp Pro Val Val Asn Lys Leu Asn Arg Ile Ile Asp Arg 
1025                1030                1035                1040

Asp Ser Glu Tyr Lys Ala Ile Gln Asp Tyr Gln Glu Thr Arg Asn Leu 
                1045                1050                1055    

Ala Tyr Arg Asn Leu Glu Lys Leu Gln Pro Phe Tyr Asn Lys Glu Trp 
            1060                1065                1070        

Ile Val Asn Gln Gly Asn Lys Leu Thr Asp Glu Ser Asn Leu Val Lys 
        1075                1080                1085            

Lys Thr Val Leu Ser Val Thr Gly Met Lys Ser Gly Gln Phe Val Thr 
    1090                1095                1100                

Asp Leu Ser Ser Val Asp Lys Ile Met Ile His Tyr Ala Asp Gly Thr 
1105                1110                1115                1120

Lys Glu Glu Phe Gly Val Ser Ala Ile Ser Asp Ser Arg Val Lys Gln 
                1125                1130                1135    

Val Lys Glu Tyr Asn Val Asp Asp Leu Gly Val Val Tyr Thr Pro Asn 
            1140                1145                1150        

Met Val Asp Lys Asn Arg Asp Ser Leu Ile Thr Lys Val Lys Glu Lys 
        1155                1160                1165            

Leu Ser Ser Val Ala Leu Asp Ser Ala Glu Val Lys Ser Ile Thr Asn 
    1170                1175                1180                

Asn Pro Ala Ser Leu Tyr Leu Glu Glu Ser Phe Ala Glu Val Arg Glu 
1185                1190                1195                1200

Thr Leu Asp Lys Leu Val Lys Ser Leu Leu Glu Asn Glu Asp His Gln 
                1205                1210                1215    

Leu Asn Ser Asp Glu Val Ala Glu Lys Ala Leu Leu Lys Lys Val Glu 
            1220                1225                1230        

Asp Asn Lys Ala Lys Ile Ile Leu Ala Leu Thr Tyr Leu Asn Arg Tyr 
        1235                1240                1245            

Tyr Gly Ile Asp Tyr Asp Gly Leu Asn Phe Lys His Leu Met Met Phe 
    1250                1255                1260                

Lys Pro Asp Phe Tyr Gly Lys Thr Pro Ser Ile Leu Asp Phe Leu Ile 
1265                1270                1275                1280

Arg Ile Gly Ser Ala Glu Lys Asn Leu Lys Gly Asp Arg Ser Leu Glu 
                1285                1290                1295    

Ala Tyr Arg Glu Val Ile Gly Gly Thr Ile Gly Lys Gly Glu Leu Asn 
            1300                1305                1310        

Gly Leu Leu Gly Tyr Asn Met Arg Leu Phe Thr Lys Tyr Thr Asp Leu 
        1315                1320                1325            

Asn Asp Trp Phe Ile His Ala Ala Lys Asn Val Tyr Val Ser Glu Pro 
    1330                1335                1340                

Glu Thr Thr Thr Glu Asp Phe Lys Asp Lys Arg His Arg Ile Tyr Asp 
1345                1350                1355                1360

Gly Leu Asn Asn Asp Val His Gly Arg Met Ile Leu Pro Leu Leu Asn 
                1365                1370                1375    

Leu Lys Lys Ala His Ile Phe Val Ile Ser Thr Tyr Asn Thr Ile Ala 
            1380                1385                1390        

Phe Ser Ser Phe Glu Lys Tyr Gly Lys Asn Thr Glu Glu Glu Arg Asn 
        1395                1400                1405            

Ala Tyr Lys Ala Glu Ile Asp Arg Val Ala Lys Ala Gln Gln Arg Tyr 
    1410                1415                1420                

Leu Asp Phe Trp Ser Arg Leu Ala Leu Pro Lys Val Arg Asn Gln Leu 
1425                1430                1435                1440

Leu Lys Ser Gln Asn Ser Val Pro Thr Pro Val Trp Asp Asn Gln Val 
                1445                1450                1455    

Tyr Val Gly Leu Gly Gly Ala Asn Arg Met Gly Tyr Gly Asp Gly Gly 
            1460                1465                1470        

Arg Val Val Thr Pro Val Arg Glu Leu Phe Gly Pro Thr Asp Arg Trp 
        1475                1480                1485            

His Gln Ile Asn Trp Asn Met Gly Ala Met Ala Lys Ile Tyr Glu Arg 
    1490                1495                1500                

Pro Trp Lys Asp Asp Gln Val Tyr Phe Met Val Thr Asn Met Met Glu 
1505                1510                1515                1520

Pro Phe Gly Ile Ser Ala Phe Thr His Glu Thr Thr His Val Asn Asp 
                1525                1530                1535    

Arg Met Ala Tyr Tyr Gly Gly Asp Trp His Arg Glu Gly Thr Asp Leu 
            1540                1545                1550        

Glu Ala Phe Ala Gln Gly Met Leu Gln Thr Pro Asp Lys Ser Thr Thr 
        1555                1560                1565            

Asn Gly Glu Tyr Gly Ala Leu Gly Ile Asn Met Ala Tyr Glu Arg Lys 
    1570                1575                1580                

Asn Asp Gly Glu Gln Leu Tyr Asn Tyr Asp Pro Glu Lys Leu Asp Ser 
1585                1590                1595                1600

Arg Glu Lys Ile Asp Ser Tyr Met Lys Asn Tyr Asn Glu Ser Met Met 
                1605                1610                1615    

Met Leu Asp Tyr Leu Glu Ala Ser Ala Val Ile Arg Gln Asn Leu Ser 
            1620                1625                1630        

Asp Asn Ser Lys Trp Phe Lys Lys Met Asp Lys Glu Trp Arg Thr Asn 
        1635                1640                1645            

Ala Asp Arg Asn Arg Leu Ile Gly Glu Pro His Gln Trp Asp Lys Leu 
    1650                1655                1660                

Arg Asp Leu Thr Glu Glu Glu Lys Lys Leu Pro Ile Asp Ser Ile Asp 
1665                1670                1675                1680

Lys Leu Val Glu Asn Asn Phe Val Thr Leu His Gly Met Pro Lys Asn 
                1685                1690                1695    

Gly Arg Tyr Arg Thr Glu Gly Phe Asp Ser Ser Tyr Gln Pro Val Asn 
            1700                1705                1710        

Met Met Ala Gly Val Phe Gly Gly Asn Thr Ser Lys Ser Thr Val Gly 
        1715                1720                1725            

Ser Ile Ser Phe Lys His Asn Ala Phe Arg Met Trp Gly Tyr Tyr Gly 
    1730                1735                1740                

Tyr Glu Asn Gly Phe Ile Pro Tyr Val Ser Asn Lys Leu Lys Gly Ala 
1745                1750                1755                1760

Ala Asn Lys Glu Asn Lys Gly Leu Leu Gly Asp Asp Phe Ile Ile Lys 
                1765                1770                1775    

Lys Val Ser Lys Asn Gln Phe Gln Asn Leu Glu Glu Trp Lys Lys His 
            1780                1785                1790        

Trp Tyr His Glu Val Tyr Asp Lys Ala Gln Lys Gly Phe Val Glu Ile 
        1795                1800                1805            

Glu Val Asp Gly Val Lys Ile Ser Thr Tyr Ala Gln Leu Gln Ser Leu 
    1810                1815                1820                

Phe Glu Glu Ala Val Ser Lys Asp Leu Ala Gly Met Asp Asp Lys Asn 
1825                1830                1835                1840

Ile Lys Asn His Tyr Gln Tyr Thr Glu Asn Leu Lys Trp Lys Ile Tyr 
                1845                1850                1855    

Lys Gln Leu Leu Lys Asn Thr Asp Gly Phe Ser Ser Asp Leu Phe Thr 
            1860                1865                1870        

Ala Pro Gln Ala 
        1875    

<210>   23
<211>   448
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   23
Met Lys Ile Leu Pro Phe Ile Ala Arg Gly Thr Ser Tyr Tyr Leu Lys 
1               5                   10                  15      

Met Ser Val Lys Lys Leu Val Pro Phe Leu Val Val Gly Leu Met Leu 
            20                  25                  30          

Ala Ala Gly Asp Ser Val Tyr Ala Tyr Ser Arg Gly Asn Gly Ser Ile 
        35                  40                  45              

Ala Arg Gly Asp Asp Tyr Pro Ala Tyr Tyr Lys Asn Gly Ser Gln Glu 
    50                  55                  60                  

Ile Asp Gln Trp Arg Met Tyr Ser Arg Gln Cys Thr Ser Phe Val Ala 
65                  70                  75                  80  

Phe Arg Leu Ser Asn Val Asn Gly Phe Glu Ile Pro Ala Ala Tyr Gly 
                85                  90                  95      

Asn Ala Asn Glu Trp Gly His Arg Ala Arg Arg Glu Gly Tyr Arg Val 
            100                 105                 110         

Asp Asn Thr Pro Thr Ile Gly Ser Ile Thr Trp Ser Thr Ala Gly Thr 
        115                 120                 125             

Tyr Gly His Val Ala Trp Val Ser Asn Val Met Gly Asp Gln Ile Glu 
    130                 135                 140                 

Ile Glu Glu Tyr Asn Tyr Gly Tyr Thr Glu Ser Tyr Asn Lys Arg Val 
145                 150                 155                 160 

Ile Lys Ala Asn Thr Met Thr Gly Phe Ile His Phe Lys Asp Leu Asp 
                165                 170                 175     

Ser Gly Ser Val Gly Asn Ser Gln Ser Ser Ala Ser Thr Gly Gly Thr 
            180                 185                 190         

His Tyr Phe Lys Thr Lys Ser Ala Ile Lys Thr Glu Pro Leu Val Ser 
        195                 200                 205             

Ala Thr Val Ile Asp Tyr Tyr Tyr Pro Gly Glu Lys Val His Tyr Asp 
    210                 215                 220                 

Gln Ile Leu Glu Lys Asp Gly Tyr Lys Trp Leu Ser Tyr Thr Ala Tyr 
225                 230                 235                 240 

Asn Gly Ser Tyr Arg Tyr Val Gln Leu Glu Ala Val Asn Lys Asn Pro 
                245                 250                 255     

Leu Gly Asn Ser Val Leu Ser Ser Thr Gly Gly Thr His Tyr Phe Lys 
            260                 265                 270         

Ile Lys Ser Ala Ile Lys Thr Glu Pro Leu Val Ser Ala Thr Val Ile 
        275                 280                 285             

Asp Tyr Tyr Tyr Pro Gly Glu Lys Val His Tyr Asp Gln Ile Leu Glu 
    290                 295                 300                 

Lys Asp Gly Tyr Lys Trp Leu Ser Tyr Thr Ala Tyr Asn Gly Ser Arg 
305                 310                 315                 320 

Arg Tyr Ile Gln Leu Glu Gly Val Thr Ser Ser Gln Asn Tyr Gln Asn 
                325                 330                 335     

Gln Ser Gly Asn Ile Ser Ser Tyr Gly Ser Asn Asn Ser Ser Thr Val 
            340                 345                 350         

Gly Trp Lys Lys Ile Asn Gly Ser Trp Tyr His Phe Lys Ser Asn Gly 
        355                 360                 365             

Ser Lys Ser Thr Gly Trp Leu Lys Asp Gly Ser Ser Trp Tyr Tyr Leu 
    370                 375                 380                 

Lys Leu Ser Gly Glu Met Gln Thr Gly Trp Leu Lys Glu Asn Gly Ser 
385                 390                 395                 400 

Trp Tyr Tyr Leu Gly Ser Ser Gly Ala Met Lys Thr Gly Trp Tyr Gln 
                405                 410                 415     

Val Ser Gly Glu Trp Tyr Tyr Ser Tyr Ser Ser Gly Ala Leu Ala Ile 
            420                 425                 430         

Asn Thr Thr Val Asp Gly Tyr Arg Val Asn Ser Asp Gly Glu Arg Val 
        435                 440                 445             


<210>   24
<211>   42
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   24
Met Leu Thr Asp Trp Gln Lys Val Asn Gly Asn Trp Tyr Tyr Leu Asn 
1               5                   10                  15      

Ser Asn Gly Ala Met Val Thr Gly Ser Gln Thr Ile Asp Gly Lys Val 
            20                  25                  30          

Tyr Asn Phe Ala Ser Ser Gly Glu Trp Ile 
        35                  40          

<210>   25
<211>   204
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   25
Met Phe Lys Arg Ile Arg Arg Val Leu Val Leu Ala Val Phe Leu Phe 
1               5                   10                  15      

Ala Gly Tyr Lys Ala Tyr Arg Val His Gln Asp Val Lys Gln Val Met 
            20                  25                  30          

Thr Tyr Gln Pro Met Val Arg Glu Ile Leu Ser Glu Gln Asp Thr Pro 
        35                  40                  45              

Ala Asn Glu Glu Leu Val Leu Ala Met Ile Tyr Thr Glu Thr Lys Gly 
    50                  55                  60                  

Lys Glu Gly Asp Val Met Gln Ser Ser Glu Ser Ala Ser Gly Ser Thr 
65                  70                  75                  80  

Asn Thr Ile Asn Asp Asn Ala Ser Ser Ile Arg Gln Gly Ile Gln Thr 
                85                  90                  95      

Leu Thr Gly Asn Leu Tyr Leu Ala Gln Lys Lys Gly Val Asp Ile Trp 
            100                 105                 110         

Thr Ala Val Gln Ala Tyr Asn Phe Gly Pro Ala Tyr Ile Asp Phe Ile 
        115                 120                 125             

Ala Gln Asn Gly Lys Glu Asn Thr Leu Ala Leu Ala Lys Gln Tyr Ser 
    130                 135                 140                 

Arg Glu Thr Val Ala Pro Leu Leu Gly Asn Arg Thr Gly Lys Thr Tyr 
145                 150                 155                 160 

Ser Tyr Ile His Pro Ile Ser Ile Phe His Gly Ala Glu Leu Tyr Val 
                165                 170                 175     

Asn Gly Gly Asn Tyr Tyr Tyr Ser Arg Gln Val Arg Leu Asn Leu Tyr 
            180                 185                 190         

Ile Ile Lys Cys Phe Thr Leu Phe Ser Thr Ser Gly 
        195                 200                 

<210>   26
<211>   339
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   26
Met Val Lys Lys Asn Asp Leu Phe Val Asp Val Ser Ser His Asn Gly 
1               5                   10                  15      

Tyr Asp Ile Thr Gly Ile Leu Glu Gln Met Gly Thr Thr Asn Thr Ile 
            20                  25                  30          

Ile Lys Ile Ser Glu Ser Thr Thr Tyr Leu Asn Pro Cys Leu Ser Ala 
        35                  40                  45              

Gln Val Glu Gln Ser Asn Pro Ile Gly Phe Tyr His Phe Ala Arg Phe 
    50                  55                  60                  

Gly Gly Asp Val Ala Glu Ala Glu Arg Glu Ala Gln Phe Phe Leu Asp 
65                  70                  75                  80  

Asn Val Pro Met Gln Val Lys Tyr Leu Val Leu Asp Tyr Glu Asp Asp 
                85                  90                  95      

Pro Ser Gly Asp Ala Gln Ala Asn Thr Asn Ala Cys Leu Arg Phe Met 
            100                 105                 110         

Gln Met Ile Ala Asp Ala Gly Tyr Lys Pro Ile Tyr Tyr Ser Tyr Lys 
        115                 120                 125             

Pro Phe Thr His Asp Asn Val Asp Tyr Gln Gln Ile Leu Ala Gln Phe 
    130                 135                 140                 

Pro Asn Ser Leu Trp Ile Ala Gly Tyr Gly Leu Asn Asp Gly Thr Ala 
145                 150                 155                 160 

Asn Phe Glu Tyr Phe Pro Ser Met Asp Gly Ile Arg Trp Trp Gln Tyr 
                165                 170                 175     

Ser Ser Asn Pro Phe Asp Lys Asn Ile Val Leu Leu Asp Asp Glu Glu 
            180                 185                 190         

Asp Asp Lys Pro Lys Thr Ala Gly Thr Trp Lys Gln Asp Ser Lys Gly 
        195                 200                 205             

Trp Trp Phe Arg Arg Asn Asn Gly Ser Phe Pro Tyr Asn Lys Trp Glu 
    210                 215                 220                 

Lys Ile Gly Gly Val Trp Tyr Tyr Phe Asp Ser Lys Gly Tyr Cys Leu 
225                 230                 235                 240 

Thr Ser Glu Trp Leu Lys Asp Asn Glu Lys Trp Tyr Tyr Leu Lys Asp 
                245                 250                 255     

Asn Gly Ala Met Ala Thr Gly Trp Val Leu Val Gly Ser Glu Trp Tyr 
            260                 265                 270         

Tyr Met Asp Asp Ser Gly Ala Met Val Thr Gly Trp Val Lys Tyr Lys 
        275                 280                 285             

Asn Asn Trp Tyr Tyr Met Thr Asn Glu Arg Gly Asn Met Val Ser Asn 
    290                 295                 300                 

Glu Phe Ile Lys Ser Gly Lys Gly Trp Tyr Phe Met Asn Thr Asn Gly 
305                 310                 315                 320 

Glu Leu Ala Asp Asn Pro Ser Phe Thr Lys Glu Pro Asp Gly Leu Ile 
                325                 330                 335     

Thr Val Ala 
            

<210>   27
<211>   612
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   27
Met Phe Ala Phe Lys Lys Arg Arg Lys Val His Tyr Ser Ile Arg Lys 
1               5                   10                  15      

Phe Ser Ile Gly Val Ala Ser Val Ala Val Ala Ser Leu Phe Met Gly 
            20                  25                  30          

Ser Val Val His Ala Thr Glu Lys Glu Val Thr Thr Gln Val Ala Thr 
        35                  40                  45              

Ser Ser Asn Lys Ala Asn Lys Ser Gln Thr Glu His Met Lys Ala Ala 
    50                  55                  60                  

Lys Gln Val Asp Glu Tyr Ile Glu Lys Met Leu Ser Glu Ile Gln Leu 
65                  70                  75                  80  

Asp Arg Arg Lys His Thr Gln Asn Val Gly Leu Leu Thr Lys Leu Gly 
                85                  90                  95      

Ala Ile Lys Thr Glu Tyr Leu Arg Gly Leu Ser Val Ser Lys Glu Lys 
            100                 105                 110         

Ser Thr Ala Glu Leu Pro Ser Glu Ile Lys Glu Lys Leu Thr Ala Ala 
        115                 120                 125             

Phe Glu Gln Phe Lys Lys Asp Thr Leu Lys Ser Gly Lys Lys Val Ala 
    130                 135                 140                 

Glu Ala Gln Lys Lys Ala Lys Asp Gln Lys Glu Ala Lys Gln Glu Ile 
145                 150                 155                 160 

Glu Ala Leu Ile Val Lys His Lys Gly Arg Glu Ile Asp Leu Asp Arg 
                165                 170                 175     

Lys Lys Ala Lys Ala Ala Val Thr Glu His Leu Lys Lys Leu Leu Asn 
            180                 185                 190         

Asp Ile Glu Lys Asn Leu Lys Lys Glu Gln His Thr His Thr Val Glu 
        195                 200                 205             

Leu Ile Lys Asn Leu Lys Asp Ile Glu Lys Thr Tyr Leu His Lys Leu 
    210                 215                 220                 

Asp Glu Ser Thr Gln Lys Ala Gln Leu Gln Lys Leu Ile Ala Glu Ser 
225                 230                 235                 240 

Gln Ser Lys Leu Asp Glu Ala Phe Ser Lys Phe Lys Asn Gly Leu Ser 
                245                 250                 255     

Ser Ser Ser Asn Ser Gly Ser Ser Thr Lys Pro Glu Thr Pro Gln Pro 
            260                 265                 270         

Glu Thr Pro Lys Pro Glu Val Lys Pro Glu Leu Glu Thr Pro Lys Pro 
        275                 280                 285             

Glu Val Lys Pro Glu Pro Glu Thr Pro Lys Pro Glu Val Lys Pro Glu 
    290                 295                 300                 

Pro Glu Thr Pro Lys Pro Glu Val Lys Pro Glu Leu Glu Thr Pro Lys 
305                 310                 315                 320 

Pro Glu Val Lys Pro Glu Pro Glu Thr Pro Lys Pro Glu Val Lys Pro 
                325                 330                 335     

Glu Pro Glu Thr Pro Lys Pro Glu Val Lys Pro Glu Pro Glu Thr Pro 
            340                 345                 350         

Lys Pro Glu Val Lys Pro Glu Leu Glu Thr Pro Lys Pro Glu Val Lys 
        355                 360                 365             

Pro Glu Leu Glu Thr Pro Lys Pro Glu Val Lys Pro Glu Pro Glu Thr 
    370                 375                 380                 

Pro Lys Pro Glu Val Lys Pro Glu Leu Glu Thr Pro Lys Pro Glu Val 
385                 390                 395                 400 

Lys Pro Glu Pro Glu Thr Pro Lys Pro Glu Val Lys Pro Glu Leu Glu 
                405                 410                 415     

Thr Pro Lys Pro Glu Val Lys Pro Glu Pro Glu Thr Pro Lys Pro Glu 
            420                 425                 430         

Val Lys Pro Glu Leu Glu Thr Pro Lys Pro Glu Val Lys Pro Glu Pro 
        435                 440                 445             

Glu Thr Pro Lys Pro Glu Val Lys Pro Glu Pro Glu Thr Pro Lys Pro 
    450                 455                 460                 

Glu Val Lys Pro Glu Pro Glu Thr Pro Lys Pro Glu Val Lys Pro Glu 
465                 470                 475                 480 

Leu Glu Thr Pro Lys Gln Lys Val Lys Pro Glu Pro Glu Thr Pro Lys 
                485                 490                 495     

Pro Glu Val Lys Pro Glu Pro Glu Thr Pro Lys Pro Glu Val Lys Pro 
            500                 505                 510         

Glu Leu Glu Thr Pro Lys Pro Glu Val Lys Pro Glu Leu Glu Ile Pro 
        515                 520                 525             

Lys Pro Glu Val Lys Pro Asp Asn Ser Lys Pro Gln Ala Asp Asp Lys 
    530                 535                 540                 

Lys Pro Ser Thr Pro Asn Asn Leu Ser Lys Asp Lys Gln Ser Ser Asn 
545                 550                 555                 560 

Gln Ala Ser Thr Asn Glu Asn Lys Lys Gln Gly Pro Ala Thr Asn Lys 
                565                 570                 575     

Pro Lys Lys Ser Leu Pro Ser Thr Gly Ser Ile Ser Asn Leu Ala Leu 
            580                 585                 590         

Glu Ile Ala Gly Leu Leu Thr Leu Ala Gly Ala Thr Ile Leu Ala Lys 
        595                 600                 605             

Lys Arg Met Lys 
    610         

<210>   28
<211>   313
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   28
Met Lys Lys Lys Leu Leu Ala Gly Ala Ile Thr Leu Leu Ser Val Ala 
1               5                   10                  15      

Thr Leu Ala Ala Cys Ser Lys Gly Ser Glu Gly Ala Asp Leu Ile Ser 
            20                  25                  30          

Met Lys Gly Asp Val Ile Thr Glu His Gln Phe Tyr Glu Gln Val Lys 
        35                  40                  45              

Asn Asn Pro Ser Ala Gln Gln Val Leu Leu Asn Met Thr Ile Gln Lys 
    50                  55                  60                  

Val Phe Glu Lys Gln Tyr Gly Ser Glu Leu Asp Asp Lys Glu Val Asp 
65                  70                  75                  80  

Asp Thr Ile Ala Glu Glu Lys Lys Gln Tyr Gly Glu Asn Tyr Gln Arg 
                85                  90                  95      

Val Leu Ser Gln Ala Gly Met Thr Leu Glu Thr Arg Lys Ala Gln Ile 
            100                 105                 110         

Arg Thr Ser Lys Leu Val Glu Leu Ala Val Lys Lys Val Ala Glu Ala 
        115                 120                 125             

Glu Leu Thr Asp Glu Ala Tyr Lys Lys Ala Phe Asp Glu Tyr Thr Pro 
    130                 135                 140                 

Asp Val Thr Ala Gln Ile Ile Arg Leu Asn Asn Glu Asp Lys Ala Lys 
145                 150                 155                 160 

Glu Val Leu Glu Lys Ala Lys Ala Glu Gly Ala Asp Phe Ala Gln Leu 
                165                 170                 175     

Ala Lys Asp Asn Ser Thr Asp Glu Lys Thr Lys Glu Asn Gly Gly Glu 
            180                 185                 190         

Ile Thr Phe Asp Ser Ala Ser Thr Glu Val Pro Glu Gln Val Lys Lys 
        195                 200                 205             

Ala Ala Phe Ala Leu Asp Val Asp Gly Val Ser Asp Val Ile Thr Ala 
    210                 215                 220                 

Thr Gly Thr Gln Ala Tyr Ser Ser Gln Tyr Tyr Ile Val Lys Leu Thr 
225                 230                 235                 240 

Lys Lys Thr Glu Lys Ser Ser Asn Ile Asp Asp Tyr Lys Glu Lys Leu 
                245                 250                 255     

Lys Thr Val Ile Leu Thr Gln Lys Gln Asn Asp Ser Thr Phe Val Gln 
            260                 265                 270         

Ser Ile Ile Gly Lys Glu Leu Gln Ala Ala Asn Ile Lys Val Lys Asp 
        275                 280                 285             

Gln Ala Phe Gln Asn Ile Phe Thr Gln Tyr Ile Gly Gly Gly Asp Ser 
    290                 295                 300                 

Ser Ser Ser Ser Ser Thr Ser Asn Glu 
305                 310             

<210>   29
<211>   619
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   29
Met Asn Lys Lys Lys Met Ile Leu Thr Ser Leu Ala Ser Val Ala Ile 
1               5                   10                  15      

Leu Gly Ala Gly Phe Val Ala Ser Gln Pro Thr Val Val Arg Ala Glu 
            20                  25                  30          

Glu Ser Pro Val Ala Ser Gln Ser Lys Ala Glu Lys Asp Tyr Asp Ala 
        35                  40                  45              

Ala Lys Lys Asp Ala Lys Asn Ala Lys Lys Ala Val Glu Asp Ala Gln 
    50                  55                  60                  

Lys Ala Leu Asp Asp Ala Lys Ala Ala Gln Lys Lys Tyr Asp Glu Asp 
65                  70                  75                  80  

Gln Lys Lys Thr Glu Glu Lys Ala Ala Leu Glu Lys Ala Ala Ser Glu 
                85                  90                  95      

Glu Met Asp Lys Ala Val Ala Ala Val Gln Gln Ala Tyr Leu Ala Tyr 
            100                 105                 110         

Gln Gln Ala Thr Asp Lys Ala Ala Lys Asp Ala Ala Asp Lys Met Ile 
        115                 120                 125             

Asp Glu Ala Lys Lys Arg Glu Glu Glu Ala Lys Thr Lys Phe Asn Thr 
    130                 135                 140                 

Val Arg Ala Met Val Val Pro Glu Pro Glu Gln Leu Ala Glu Thr Lys 
145                 150                 155                 160 

Lys Lys Ser Glu Glu Ala Lys Gln Lys Ala Pro Glu Leu Thr Lys Lys 
                165                 170                 175     

Leu Glu Glu Ala Lys Ala Lys Leu Glu Glu Ala Glu Lys Lys Ala Thr 
            180                 185                 190         

Glu Ala Lys Gln Lys Val Asp Ala Glu Glu Val Ala Pro Gln Ala Lys 
        195                 200                 205             

Ile Ala Glu Leu Glu Asn Gln Val His Arg Leu Glu Gln Glu Leu Lys 
    210                 215                 220                 

Glu Ile Asp Glu Ser Glu Ser Glu Asp Tyr Ala Lys Glu Gly Phe Arg 
225                 230                 235                 240 

Ala Pro Leu Gln Ser Lys Leu Asp Ala Lys Lys Ala Lys Leu Ser Lys 
                245                 250                 255     

Leu Glu Glu Leu Ser Asp Lys Ile Asp Glu Leu Asp Ala Glu Ile Ala 
            260                 265                 270         

Lys Leu Glu Asp Gln Leu Lys Ala Ala Glu Glu Asn Asn Asn Val Glu 
        275                 280                 285             

Asp Tyr Phe Lys Glu Gly Leu Glu Lys Thr Ile Ala Ala Lys Lys Ala 
    290                 295                 300                 

Glu Leu Glu Lys Thr Glu Ala Asp Leu Lys Lys Ala Val Asn Glu Pro 
305                 310                 315                 320 

Glu Lys Pro Ala Pro Ala Pro Glu Thr Pro Ala Pro Glu Ala Pro Ala 
                325                 330                 335     

Glu Gln Pro Lys Pro Ala Pro Ala Pro Gln Pro Ala Pro Ala Pro Lys 
            340                 345                 350         

Pro Glu Lys Pro Ala Glu Gln Pro Lys Pro Glu Lys Thr Asp Asp Gln 
        355                 360                 365             

Gln Ala Glu Glu Asp Tyr Ala Arg Arg Ser Glu Glu Glu Tyr Asn Arg 
    370                 375                 380                 

Leu Thr Gln Gln Gln Pro Pro Lys Ala Glu Lys Pro Ala Pro Ala Pro 
385                 390                 395                 400 

Lys Thr Gly Trp Lys Gln Glu Asn Gly Met Trp Tyr Phe Tyr Asn Thr 
                405                 410                 415     

Asp Gly Ser Met Ala Thr Gly Trp Leu Gln Asn Asn Gly Ser Trp Tyr 
            420                 425                 430         

Tyr Leu Asn Ser Asn Gly Ala Met Ala Thr Gly Trp Leu Gln Tyr Asn 
        435                 440                 445             

Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Ala Met Ala Thr Gly Trp 
    450                 455                 460                 

Ala Lys Val Asn Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Ala Met 
465                 470                 475                 480 

Ala Thr Gly Trp Leu Gln Tyr Asn Gly Ser Trp Tyr Tyr Leu Asn Ala 
                485                 490                 495     

Asn Gly Ala Met Ala Thr Gly Trp Ala Lys Val Asn Gly Ser Trp Tyr 
            500                 505                 510         

Tyr Leu Asn Ala Asn Gly Ala Met Ala Thr Gly Trp Leu Gln Tyr Asn 
        515                 520                 525             

Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Ala Met Ala Thr Gly Trp 
    530                 535                 540                 

Ala Lys Val Asn Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Ala Met 
545                 550                 555                 560 

Ala Thr Gly Trp Val Lys Asp Gly Asp Thr Trp Tyr Tyr Leu Glu Ala 
                565                 570                 575     

Ser Gly Ala Met Lys Ala Ser Gln Trp Phe Lys Val Ser Asp Lys Trp 
            580                 585                 590         

Tyr Tyr Val Asn Gly Leu Gly Ala Leu Ala Val Asn Thr Thr Val Asp 
        595                 600                 605             

Gly Tyr Lys Val Asn Ala Asn Gly Glu Trp Val 
    610                 615                 

<210>   30
<211>   309
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   30
Met Lys Lys Leu Gly Thr Leu Leu Val Leu Phe Leu Ser Ala Ile Ile 
1               5                   10                  15      

Leu Val Ala Cys Ala Ser Gly Lys Lys Asp Thr Thr Ser Gly Gln Lys 
            20                  25                  30          

Leu Lys Val Val Ala Thr Asn Ser Ile Ile Ala Asp Ile Thr Lys Asn 
        35                  40                  45              

Ile Ala Gly Asp Lys Ile Asp Leu His Ser Ile Val Pro Ile Gly Gln 
    50                  55                  60                  

Asp Pro His Glu Tyr Glu Pro Leu Pro Glu Asp Val Lys Lys Thr Ser 
65                  70                  75                  80  

Glu Ala Asp Leu Ile Phe Tyr Asn Gly Ile Asn Leu Glu Thr Gly Gly 
                85                  90                  95      

Asn Ala Trp Phe Thr Lys Leu Val Glu Asn Ala Lys Lys Thr Glu Asn 
            100                 105                 110         

Lys Asp Tyr Phe Ala Val Ser Asp Gly Val Asp Val Ile Tyr Leu Glu 
        115                 120                 125             

Gly Gln Asn Glu Lys Gly Lys Glu Asp Pro His Ala Trp Leu Asn Leu 
    130                 135                 140                 

Glu Asn Gly Ile Ile Phe Ala Lys Asn Ile Ala Lys Gln Leu Ser Ala 
145                 150                 155                 160 

Lys Asp Pro Asn Asn Lys Glu Phe Tyr Glu Lys Asn Leu Lys Glu Tyr 
                165                 170                 175     

Thr Asp Lys Leu Asp Lys Leu Asp Lys Glu Ser Lys Asp Lys Phe Asn 
            180                 185                 190         

Lys Ile Pro Ala Glu Lys Lys Leu Ile Val Thr Ser Glu Gly Ala Phe 
        195                 200                 205             

Lys Tyr Phe Ser Lys Ala Tyr Gly Val Pro Ser Ala Tyr Ile Trp Glu 
    210                 215                 220                 

Ile Asn Thr Glu Glu Glu Gly Thr Pro Glu Gln Ile Lys Thr Leu Val 
225                 230                 235                 240 

Glu Lys Leu Arg Gln Thr Lys Val Pro Ser Leu Phe Val Glu Ser Ser 
                245                 250                 255     

Val Asp Asp Arg Pro Met Lys Thr Val Ser Gln Asp Thr Asn Ile Pro 
            260                 265                 270         

Ile Tyr Ala Gln Ile Phe Thr Asp Ser Ile Ala Glu Gln Gly Lys Glu 
        275                 280                 285             

Gly Asp Ser Tyr Tyr Ser Met Met Lys Tyr Asn Leu Asp Lys Ile Ala 
    290                 295                 300                 

Glu Gly Leu Ala Lys 
305                 

<210>   31
<211>   2144
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   31
Met Lys Lys Ser Thr Val Leu Ser Leu Thr Thr Ala Ala Val Ile Leu 
1               5                   10                  15      

Ala Ala Tyr Ala Pro Asn Glu Val Val Leu Ala Asp Thr Ser Ser Ser 
            20                  25                  30          

Glu Asp Ala Leu Ser Ile Ser Asp Lys Glu Lys Val Val Val Asp Lys 
        35                  40                  45              

Glu Thr Glu Asn Lys Glu Lys His Lys Asp Ile His Asn Ala Ile Glu 
    50                  55                  60                  

Thr Ser Lys Asp Thr Glu Glu Lys Lys Thr Thr Ile Ile Glu Glu Lys 
65                  70                  75                  80  

Glu Val Val Ser Lys Asn Pro Val Ile Asp Thr Lys Thr Ser Asn Glu 
                85                  90                  95      

Glu Ala Lys Ile Lys Glu Glu Asn Ser Asn Gln Ser Gln Gly Asp His 
            100                 105                 110         

Thr Asp Ser Phe Val Asn Lys Asn Thr Glu Asn Pro Lys Lys Glu Asp 
        115                 120                 125             

Lys Val Val Tyr Ile Ala Glu Phe Lys Asp Lys Glu Ser Gly Glu Lys 
    130                 135                 140                 

Ala Ile Lys Gly Leu Ser Asn Leu Lys Asn Thr Lys Val Leu Tyr Thr 
145                 150                 155                 160 

Tyr Asp Arg Ile Phe Asn Gly Ser Ala Ile Glu Thr Thr Pro Asp Asn 
                165                 170                 175     

Leu Asp Lys Ile Lys Gln Ile Glu Gly Ile Ser Ser Ile Glu Arg Ala 
            180                 185                 190         

Gln Lys Val Gln Pro Met Met Asn His Ala Arg Lys Glu Ile Gly Val 
        195                 200                 205             

Glu Glu Ala Ile Asp Tyr Leu Lys Ser Ile Asn Ala Pro Phe Gly Lys 
    210                 215                 220                 

Asn Phe Asp Gly Arg Gly Met Val Ile Ser Asn Ile Asp Thr Gly Thr 
225                 230                 235                 240 

Asp Tyr Arg His Lys Ala Met Arg Ile Asp Asp Asp Ala Lys Ala Ser 
                245                 250                 255     

Met Arg Phe Lys Lys Glu Asp Leu Lys Gly Thr Asp Lys Asn Tyr Trp 
            260                 265                 270         

Leu Ser Asp Lys Ile Pro His Ala Phe Asn Tyr Tyr Asn Gly Gly Lys 
        275                 280                 285             

Ile Thr Val Glu Lys Tyr Asp Asp Gly Arg Asp Tyr Phe Asp Pro His 
    290                 295                 300                 

Gly Met His Ile Ala Gly Ile Leu Ala Gly Asn Asp Thr Glu Gln Asp 
305                 310                 315                 320 

Ile Lys Asn Phe Asn Gly Ile Asp Gly Ile Ala Pro Asn Ala Gln Ile 
                325                 330                 335     

Phe Ser Tyr Lys Met Tyr Ser Asp Ala Gly Ser Gly Phe Ala Gly Asp 
            340                 345                 350         

Glu Thr Met Phe His Ala Ile Glu Asp Ser Ile Lys His Asn Val Asp 
        355                 360                 365             

Val Val Ser Val Ser Ser Gly Phe Thr Gly Thr Gly Leu Val Gly Glu 
    370                 375                 380                 

Lys Tyr Trp Gln Ala Ile Arg Ala Leu Arg Lys Ala Gly Ile Pro Met 
385                 390                 395                 400 

Val Val Ala Thr Gly Asn Tyr Ala Thr Ser Ala Ser Ser Ser Ser Trp 
                405                 410                 415     

Asp Leu Val Ala Asn Asn His Leu Lys Met Thr Asp Thr Gly Asn Val 
            420                 425                 430         

Thr Arg Thr Ala Ala His Glu Asp Ala Ile Ala Val Ala Ser Ala Lys 
        435                 440                 445             

Asn Gln Thr Val Glu Phe Asp Lys Val Asn Ile Gly Gly Glu Ser Phe 
    450                 455                 460                 

Lys Tyr Arg Asn Ile Gly Ala Phe Phe Asp Lys Asn Lys Ile Thr Thr 
465                 470                 475                 480 

Asn Glu Asp Gly Thr Lys Ala Pro Ser Lys Leu Lys Phe Val Tyr Ile 
                485                 490                 495     

Gly Lys Gly Gln Asp Gln Asp Leu Ile Gly Leu Asp Leu Arg Gly Lys 
            500                 505                 510         

Ile Ala Val Met Asp Arg Ile Tyr Thr Lys Asp Leu Lys Asn Ala Phe 
        515                 520                 525             

Lys Lys Ala Met Asp Lys Gly Ala Arg Ala Ile Met Val Val Asn Thr 
    530                 535                 540                 

Val Asn Tyr Tyr Asn Arg Asp Asn Trp Thr Glu Leu Pro Ala Met Gly 
545                 550                 555                 560 

Tyr Glu Ala Asp Glu Gly Thr Lys Ser Gln Val Phe Ser Ile Ser Gly 
                565                 570                 575     

Asp Asp Gly Val Lys Leu Trp Asn Met Ile Asn Pro Asp Lys Lys Thr 
            580                 585                 590         

Glu Val Lys Arg Asn Asn Lys Glu Asp Phe Lys Asp Lys Leu Glu Gln 
        595                 600                 605             

Tyr Tyr Pro Ile Asp Met Glu Ser Phe Asn Ser Asn Lys Pro Asn Val 
    610                 615                 620                 

Gly Asp Glu Lys Glu Ile Asp Phe Lys Phe Ala Pro Asp Thr Asp Lys 
625                 630                 635                 640 

Glu Leu Tyr Lys Glu Asp Ile Ile Val Pro Ala Gly Ser Thr Ser Trp 
                645                 650                 655     

Gly Pro Arg Ile Asp Leu Leu Leu Lys Pro Asp Val Ser Ala Pro Gly 
            660                 665                 670         

Lys Asn Ile Lys Ser Thr Leu Asn Val Ile Asn Gly Lys Ser Thr Tyr 
        675                 680                 685             

Gly Tyr Met Ser Gly Thr Ser Met Ala Thr Pro Ile Val Ala Ala Ser 
    690                 695                 700                 

Thr Val Leu Ile Arg Pro Lys Leu Lys Glu Met Leu Glu Arg Pro Val 
705                 710                 715                 720 

Leu Lys Asn Leu Lys Gly Asp Asp Lys Ile Asp Leu Thr Ser Leu Thr 
                725                 730                 735     

Lys Ile Ala Leu Gln Asn Thr Ala Arg Pro Met Met Asp Ala Thr Ser 
            740                 745                 750         

Trp Lys Glu Lys Ser Gln Tyr Phe Ala Ser Pro Arg Gln Gln Gly Ala 
        755                 760                 765             

Gly Leu Ile Asn Val Ala Asn Ala Leu Arg Asn Glu Val Val Ala Thr 
    770                 775                 780                 

Phe Lys Asn Thr Asp Ser Lys Gly Leu Val Asn Ser Tyr Gly Ser Ile 
785                 790                 795                 800 

Ser Leu Lys Glu Ile Lys Gly Asp Lys Lys Tyr Phe Thr Ile Lys Leu 
                805                 810                 815     

His Asn Thr Ser Asn Arg Pro Leu Thr Phe Lys Val Ser Ala Ser Ala 
            820                 825                 830         

Ile Thr Thr Asp Ser Leu Thr Asp Arg Leu Lys Leu Asp Glu Thr Tyr 
        835                 840                 845             

Lys Asp Glu Lys Ser Pro Asp Gly Lys Gln Ile Val Pro Glu Ile His 
    850                 855                 860                 

Pro Glu Lys Val Lys Gly Ala Asn Ile Thr Phe Glu His Gly Thr Phe 
865                 870                 875                 880 

Thr Ile Gly Ala Asn Ser Ser Phe Asp Leu Asn Ala Val Ile Asn Val 
                885                 890                 895     

Gly Glu Ala Lys Asn Lys Asn Lys Phe Val Glu Ser Phe Ile His Phe 
            900                 905                 910         

Glu Ser Val Glu Glu Met Glu Ala Leu Asn Ser Asn Gly Lys Lys Ile 
        915                 920                 925             

Asn Phe Gln Pro Ser Leu Ser Met Pro Leu Met Gly Phe Ala Gly Asn 
    930                 935                 940                 

Trp Asn His Glu Pro Ile Leu Asp Lys Trp Ala Trp Glu Glu Gly Ser 
945                 950                 955                 960 

Arg Ser Lys Thr Leu Gly Gly Tyr Asp Asp Asp Gly Lys Pro Lys Ile 
                965                 970                 975     

Pro Gly Thr Leu Asn Lys Gly Ile Gly Gly Glu His Gly Ile Asp Lys 
            980                 985                 990         

Phe Asn Pro Ala Gly Val Ile Gln Asn Arg Lys Asp Lys Asn Thr Thr 
        995                 1000                1005            

Ser Leu Asp Gln Asn Pro Glu Leu Phe Ala Phe Asn Asn Gln Gly Ile 
    1010                1015                1020                

Asn Ala Pro Ser Ser Ser Gly Ser Lys Ile Ala Asn Ile Tyr Pro Leu 
1025                1030                1035                1040

Asp Ser Asn Gly Asn Pro Gln Asp Ala Gln Leu Glu Arg Gly Leu Thr 
                1045                1050                1055    

Pro Ser Pro Leu Val Leu Arg Ser Ala Glu Glu Gly Leu Ile Ser Ile 
            1060                1065                1070        

Val Asn Thr Asn Lys Glu Gly Glu Asn Gln Arg Asp Leu Lys Val Ile 
        1075                1080                1085            

Ser Arg Glu His Phe Ile Arg Gly Ile Leu Asn Ser Lys Ser Asn Asp 
    1090                1095                1100                

Ala Lys Gly Ile Lys Ser Ser Lys Leu Lys Val Trp Gly Asp Leu Lys 
1105                1110                1115                1120

Trp Asp Gly Leu Ile Tyr Asn Pro Arg Gly Arg Glu Glu Asn Ala Pro 
                1125                1130                1135    

Glu Ser Lys Asp Asn Gln Asp Pro Ala Thr Lys Ile Arg Gly Gln Phe 
            1140                1145                1150        

Glu Pro Ile Ala Glu Gly Gln Tyr Phe Tyr Lys Phe Lys Tyr Arg Leu 
        1155                1160                1165            

Thr Lys Asp Tyr Pro Trp Gln Val Ser Tyr Ile Pro Val Lys Ile Asp 
    1170                1175                1180                

Asn Thr Ala Pro Lys Ile Val Ser Val Asp Phe Ser Asn Pro Glu Lys 
1185                1190                1195                1200

Ile Lys Leu Ile Thr Lys Asp Thr Tyr His Lys Val Lys Asp Gln Tyr 
                1205                1210                1215    

Lys Asn Glu Thr Leu Phe Ala Arg Asp Gln Lys Glu His Pro Glu Lys 
            1220                1225                1230        

Phe Asp Glu Ile Ala Asn Glu Val Trp Tyr Ala Gly Ala Ala Leu Val 
        1235                1240                1245            

Asn Glu Asp Gly Glu Val Glu Lys Asn Leu Glu Val Thr Tyr Ala Gly 
    1250                1255                1260                

Glu Gly Gln Gly Arg Asn Arg Lys Leu Asp Lys Asp Gly Asn Thr Ile 
1265                1270                1275                1280

Tyr Glu Ile Lys Gly Ala Gly Asp Leu Arg Gly Lys Ile Ile Glu Val 
                1285                1290                1295    

Ile Ala Leu Asp Gly Ser Ser Asn Phe Thr Lys Ile His Arg Ile Lys 
            1300                1305                1310        

Phe Ala Asp Gln Ala Asp Glu Lys Gly Met Ile Ser Tyr Tyr Leu Val 
        1315                1320                1325            

Asp Pro Asp Lys Asp Ala Ser Lys Tyr Glu Lys Leu Gly Glu Ile Ser 
    1330                1335                1340                

Glu Asp Lys Leu Lys Asn Ala Lys Ser Pro Glu Glu Asn Thr Asn Asn 
1345                1350                1355                1360

Asn Gln Ala Lys Asp Glu Asp Ser Lys Pro Asp Glu Lys Ser Ser Val 
                1365                1370                1375    

Glu Gly Glu Ala Ser Leu Glu Ile Asn Lys Thr Ile Ser Thr Ile Arg 
            1380                1385                1390        

Glu Phe Glu Asn Lys Asp Leu Lys Lys Leu Ile Lys Lys Lys Phe Arg 
        1395                1400                1405            

Glu Val Asn Asp Phe Thr Ser Glu Thr Gly Lys Arg Ile Glu Glu Tyr 
    1410                1415                1420                

Asp Tyr Lys Tyr Asp Asp Lys Gly Asn Ile Ile Ala Tyr Asp Asp Gly 
1425                1430                1435                1440

Ser Ala Leu Gln Tyr Glu Thr Glu Lys Phe Asp Glu Ile Lys Ser Lys 
                1445                1450                1455    

Ile Tyr Gly Val Leu Ser Pro Ser Lys Asp Gly His Phe Glu Ile Leu 
            1460                1465                1470        

Gly Lys Ile Ser Asn Val Ser Lys Asn Ala Lys Val Tyr Tyr Gly Asn 
        1475                1480                1485            

Ser Tyr Lys Ser Ile Glu Ile Lys Ala Thr Lys Tyr Asp Ser His Ser 
    1490                1495                1500                

Lys Thr Met Ile Phe Asp Leu Tyr Ala Asn Ile Asn Asp Ile Val Asp 
1505                1510                1515                1520

Gly Leu Ala Phe Ala Gly Asp Met Arg Leu Phe Val Lys Asp Asp Asn 
                1525                1530                1535    

Gln Ile Lys Ala Glu Thr Lys Ile Arg Met Pro Glu Lys Asn Lys Glu 
            1540                1545                1550        

Thr Lys Ala Glu Tyr Pro Tyr Val Ser Ser Tyr Gly Asn Val Ile Glu 
        1555                1560                1565            

Leu Gly Glu Gly Asp Leu Ser Lys Asn Lys Pro Asp Asn Leu Thr Lys 
    1570                1575                1580                

Met Glu Ser Gly Lys Ile Tyr Ser Asp Ser Glu Lys Gln Gln Tyr Leu 
1585                1590                1595                1600

Leu Lys Asp Asn Ile Ile Leu Arg Lys Gly Tyr Ala Leu Lys Val Thr 
                1605                1610                1615    

Thr Tyr Asn Pro Gly Lys Thr Asp Met Leu Glu Gly Asn Gly Val Tyr 
            1620                1625                1630        

Ser Lys Glu Asp Ile Ala Lys Ile Gln Lys Ala Asn Pro Asn Leu Arg 
        1635                1640                1645            

Val Leu Ser Glu Thr Thr Ile Tyr Ala Asp Ser Arg Asn Val Glu Asp 
    1650                1655                1660                

Gly Arg Ser Thr Gln Ala Val Leu Met Ser Ala Leu Asp Gly Phe Asn 
1665                1670                1675                1680

Ile Ile Arg Tyr Gln Val Phe Thr Phe Lys Met Asn Asp Lys Gly Glu 
                1685                1690                1695    

Ala Ile Asp Lys Asp Gly Asn Leu Val Thr Asp Ser Ser Lys Leu Val 
            1700                1705                1710        

Leu Phe Gly Lys Asp Asp Lys Glu Tyr Thr Gly Glu Asp Lys Ser Asn 
        1715                1720                1725            

Val Glu Ala Ile Lys Glu Asp Gly Ser Met Leu Phe Ile Asp Thr Lys 
    1730                1735                1740                

Pro Val Asn Leu Ser Met Asp Lys Asn Tyr Phe Asn Pro Ser Lys Ser 
1745                1750                1755                1760

Asn Lys Ile Tyr Val Arg Asn Pro Glu Phe Tyr Leu Arg Gly Lys Ile 
                1765                1770                1775    

Ser Asp Lys Gly Gly Phe Asn Trp Glu Leu Arg Val Asn Glu Ser Val 
            1780                1785                1790        

Val Asp Asn Tyr Leu Ile Tyr Gly Asp Leu His Ile Asp Asn Thr Arg 
        1795                1800                1805            

Asp Phe Asn Ile Lys Leu Asn Val Lys Asp Gly Asp Ile Met Asp Trp 
    1810                1815                1820                

Gly Met Lys Asp Tyr Lys Ala Asn Gly Phe Pro Asp Lys Val Thr Asp 
1825                1830                1835                1840

Met Asp Gly Asn Val Tyr Leu Gln Thr Gly Tyr Ser Asp Leu Asn Ala 
                1845                1850                1855    

Lys Ala Val Gly Val His Tyr Gln Phe Leu Tyr Asp Asn Val Lys Pro 
            1860                1865                1870        

Glu Val Asn Ile Asp Pro Lys Gly Asn Thr Ser Ile Glu Tyr Ala Asp 
        1875                1880                1885            

Gly Lys Ser Val Val Phe Asn Ile Asn Asp Lys Arg Asn Asn Gly Phe 
    1890                1895                1900                

Asp Gly Glu Ile Gln Glu Gln His Ile Tyr Val Asn Gly Lys Glu Tyr 
1905                1910                1915                1920

Thr Ser Phe Asp Asp Ile Lys Gln Ile Thr Asp Lys Thr Leu Asn Ile 
                1925                1930                1935    

Lys Ile Val Val Lys Asp Phe Ala Arg Asn Thr Thr Val Lys Glu Phe 
            1940                1945                1950        

Ile Leu Asn Lys Asp Thr Gly Glu Val Ser Glu Leu Lys Pro His Arg 
        1955                1960                1965            

Val Thr Val Thr Ile Gln Asn Gly Lys Glu Met Ser Ser Thr Ile Val 
    1970                1975                1980                

Ser Glu Glu Asp Phe Ile Leu Pro Val Tyr Lys Gly Glu Leu Glu Lys 
1985                1990                1995                2000

Gly Tyr Gln Phe Asp Gly Trp Glu Ile Ser Gly Phe Glu Gly Lys Lys 
                2005                2010                2015    

Asp Ala Gly Tyr Val Ile Asn Leu Ser Lys Asp Thr Phe Ile Lys Pro 
            2020                2025                2030        

Val Phe Lys Lys Ile Glu Glu Lys Lys Glu Glu Glu Asn Lys Pro Thr 
        2035                2040                2045            

Phe Asp Val Ser Lys Lys Lys Asp Asn Pro Gln Val Asn His Ser Gln 
    2050                2055                2060                

Leu Asn Glu Ser His Arg Lys Glu Asp Leu Gln Arg Glu Asp His Ser 
2065                2070                2075                2080

Gln Lys Ser Asp Ser Thr Lys Asp Val Thr Ala Thr Val Leu Asp Lys 
                2085                2090                2095    

Asn Asn Ile Ser Ser Lys Ser Thr Thr Asn Asn Pro Asn Lys Leu Pro 
            2100                2105                2110        

Lys Thr Gly Thr Ala Ser Gly Ala Gln Thr Leu Leu Ala Ala Gly Ile 
        2115                2120                2125            

Met Phe Ile Val Gly Ile Phe Leu Gly Leu Lys Lys Lys Asn Gln Asp 
    2130                2135                2140                


<210>   32
<211>   324
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   32
Met Arg Lys Lys Leu Phe Leu Thr Ser Ala Ala Ile Leu Trp Ala Val 
1               5                   10                  15      

Thr Ala Met Asn Ser Val His Ala Ala Thr Asp Val Gln Lys Val Ile 
            20                  25                  30          

Asp Glu Thr Tyr Val Gln Pro Glu Tyr Val Leu Gly Ser Ser Leu Ser 
        35                  40                  45              

Glu Asp Gln Lys Asn Gln Thr Leu Lys Lys Leu Gly Tyr Asn Ala Ser 
    50                  55                  60                  

Thr Asp Thr Lys Glu Leu Lys Thr Met Thr Pro Asp Val Tyr Ser Lys 
65                  70                  75                  80  

Ile Met Asn Val Ala Asn Asp Ser Ser Leu Gln Leu Tyr Ser Ser Ala 
                85                  90                  95      

Lys Ile Gln Lys Leu Gly Asp Lys Ser Pro Leu Glu Val Lys Ile Glu 
            100                 105                 110         

Thr Pro Glu Asn Ile Thr Lys Val Thr Gln Asp Met Tyr Arg Asn Ala 
        115                 120                 125             

Ala Val Thr Leu Gly Val Glu His Ala Lys Ile Thr Val Ala Ala Pro 
    130                 135                 140                 

Ile Pro Val Thr Gly Glu Ser Ala Leu Ala Gly Ile Tyr Tyr Ser Leu 
145                 150                 155                 160 

Glu Ala Asn Gly Ala Lys Val Pro Gln Ala Asn Lys Asp Leu Ala Gln 
                165                 170                 175     

Glu Glu Leu Lys Ala Leu Ser Asp Ile Asn Ala Glu Asn Lys Asp Lys 
            180                 185                 190         

Ser Gly Tyr Asp Ala Asn Lys Leu Asn Val Ala Leu Ala Asp Ile Lys 
        195                 200                 205             

Ser Gly Leu Ala Lys Ala Lys Glu Ser Lys Gly Asn Leu Thr Glu Glu 
    210                 215                 220                 

Asp Ile Arg Lys Ile Val Glu Asp Thr Leu Lys Asn Tyr Lys Leu Asp 
225                 230                 235                 240 

Gln Val Ile Thr Gly Asn Gln Ile Asn Ile Ile Ile Asn Phe Ala Leu 
                245                 250                 255     

Asn Leu Ser Lys Ser Asp Ile Leu Ser Asn Ala Asp Phe Thr Lys Thr 
            260                 265                 270         

Leu Asn Asp Leu Lys Gln Ser Ile Val Ser Gln Ala Gly Asp Ser Phe 
        275                 280                 285             

Lys Asn Ile Asn Leu Asn Phe Asp Ser Asp Lys Ala Leu Glu Asp Gly 
    290                 295                 300                 

Gly Asn Phe Leu Ser Ser Leu Trp Gln Ala Leu Val Asn Phe Phe Lys 
305                 310                 315                 320 

Ser Phe Gly Ser 
                

<210>   33
<211>   339
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   33
Met His Ala Lys Met Arg Asn Lys Lys Gln Ile Asn Leu Gly Ile Ile 
1               5                   10                  15      

Phe Val Ile Cys Leu Gly Leu Leu Ile Thr Ile Phe Leu Ser Leu Lys 
            20                  25                  30          

Leu Gly Thr Lys Glu Ile Asn Ile Arg Asp Phe Leu Ala Ala Phe Gly 
        35                  40                  45              

Met Gly Asn Thr Asn Asp Asp Phe Ile Lys Ser Ile Ile Tyr Lys Arg 
    50                  55                  60                  

Ile Pro Arg Thr Ile Phe Ala Ile Leu Ala Gly Ser Ser Leu Ala Ile 
65                  70                  75                  80  

Ser Gly Val Leu Met Gln Ser Val Thr Arg Asn Pro Ile Ala Asp Pro 
                85                  90                  95      

Gly Ile Leu Gly Ile Asn Thr Gly Ala Ser Leu Ser Val Val Ile Gly 
            100                 105                 110         

Leu Ser Phe Leu Gly Ile Ser Ser Ser Ile Ser His Ile Ser Phe Ala 
        115                 120                 125             

Ile Ile Gly Gly Leu Val Ser Ala Ile Phe Val Tyr Ala Ile Ala Val 
    130                 135                 140                 

Ser Gly Lys Ala Gly Leu Thr Pro Ile Lys Leu Ala Leu Ser Gly Thr 
145                 150                 155                 160 

Cys Val Ser Met Ala Leu Ser Ser Phe Val Ser Phe Leu Ile Leu Pro 
                165                 170                 175     

Asn Asn Asn Val Leu Asp Lys Phe Arg Phe Trp Gln Ile Gly Ser Leu 
            180                 185                 190         

Gly Ala Ala Thr Leu Ser Ser Ile Ser Thr Leu Leu Pro Phe Ile Ile 
        195                 200                 205             

Leu Gly His Leu Ile Ala Ile Phe Ile Ser Ser Asp Leu Asn Ala Leu 
    210                 215                 220                 

Ala Met Gly Asp Glu Met Ala Val Gly Leu Gly Val Asn Val Asn Arg 
225                 230                 235                 240 

Ile Arg Ser Leu Ala Ile Ile Ala Ser Val Leu Leu Cys Ser Ser Ile 
                245                 250                 255     

Thr Ala Ile Gly Gly Pro Ile Gly Phe Val Gly Leu Ile Val Pro His 
            260                 265                 270         

Phe Cys Gly Leu Phe Ile Ser Lys Asp Ile Arg Thr Met Thr Ile Ser 
        275                 280                 285             

Ser Ala Phe Ile Gly Ala Glu Leu Leu Leu Ile Cys Asp Ile Ile Gly 
    290                 295                 300                 

Arg Met Leu Gly Lys Pro Gly Glu Ile Glu Val Gly Ile Ile Thr Ala 
305                 310                 315                 320 

Ile Ile Gly Gly Pro Val Leu Ile Tyr Val Thr Met Lys Asn Arg Gly 
                325                 330                 335     

Val Asn Thr 
            

<210>   34
<211>   321
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   34
Met Lys Thr Ser Leu Lys Leu Tyr Phe Thr Ala Leu Val Ala Ser Phe 
1               5                   10                  15      

Leu Leu Leu Leu Gly Ala Cys Ser Thr Asn Ser Ser Thr Ser Gln Thr 
            20                  25                  30          

Glu Thr Ser Ser Ser Ala Pro Thr Glu Ile Thr Ile Lys Ser Ser Leu 
        35                  40                  45              

Asp Glu Val Lys Leu Ser Lys Val Pro Glu Lys Ile Val Thr Phe Asp 
    50                  55                  60                  

Leu Gly Ala Ala Asp Thr Ile Arg Ala Leu Gly Phe Glu Lys Asn Ile 
65                  70                  75                  80  

Val Gly Met Pro Thr Lys Thr Val Pro Thr Tyr Leu Lys Asp Leu Val 
                85                  90                  95      

Gly Thr Val Lys Asn Val Gly Ser Met Lys Glu Pro Asp Leu Glu Ala 
            100                 105                 110         

Ile Ala Ala Leu Glu Pro Asp Leu Ile Ile Ala Ser Pro Arg Thr Gln 
        115                 120                 125             

Lys Phe Val Asp Lys Phe Lys Glu Ile Ala Pro Thr Val Leu Phe Gln 
    130                 135                 140                 

Ala Ser Lys Asp Asp Tyr Trp Thr Ser Thr Lys Ala Asn Ile Glu Ser 
145                 150                 155                 160 

Leu Ala Ser Ala Phe Gly Glu Thr Ser Thr Gln Lys Ala Lys Glu Glu 
                165                 170                 175     

Leu Ala Lys Leu Asp Lys Ser Ile Gln Glu Val Ala Thr Lys Asn Glu 
            180                 185                 190         

Ser Ser Asp Lys Lys Ala Leu Ala Ile Leu Leu Asn Glu Gly Lys Met 
        195                 200                 205             

Ala Ala Phe Gly Ala Lys Ser Arg Phe Ser Phe Leu Tyr Gln Thr Leu 
    210                 215                 220                 

Lys Phe Lys Pro Thr Asp Thr Lys Phe Glu Asp Ser Arg His Gly Gln 
225                 230                 235                 240 

Glu Val Ser Phe Glu Ser Val Lys Glu Ile Asn Pro Asp Ile Leu Phe 
                245                 250                 255     

Val Ile Asn Arg Thr Leu Ala Ile Gly Gly Asp Asn Ser Ser Asn Asp 
            260                 265                 270         

Gly Val Leu Glu Asn Ala Leu Ile Ala Glu Thr Pro Ala Ala Lys Asn 
        275                 280                 285             

Gly Lys Ile Ile Gln Leu Thr Pro Asp Leu Trp Tyr Leu Ser Gly Gly 
    290                 295                 300                 

Gly Leu Glu Ser Thr Lys Leu Met Ile Glu Asp Ile Gln Lys Ala Leu 
305                 310                 315                 320 

Lys 
    

<210>   35
<211>   122
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   35
Met Ser Lys Asn Ile Val Gln Leu Asn Asn Ser Phe Ile Gln Asn Glu 
1               5                   10                  15      

Tyr Gln Arg Arg Arg Tyr Leu Met Lys Glu Arg Gln Lys Arg Asn Arg 
            20                  25                  30          

Phe Met Gly Gly Val Leu Ile Leu Ile Met Leu Leu Phe Ile Leu Pro 
        35                  40                  45              

Thr Phe Asn Leu Ala Gln Ser Tyr Gln Gln Leu Leu Gln Arg Arg Gln 
    50                  55                  60                  

Gln Leu Ala Asp Leu Gln Thr Gln Tyr Gln Thr Leu Ser Asp Glu Lys 
65                  70                  75                  80  

Asp Lys Glu Thr Ala Phe Ala Thr Lys Leu Lys Asp Glu Asp Tyr Ala 
                85                  90                  95      

Ala Lys Tyr Thr Arg Ala Lys Tyr Tyr Tyr Ser Lys Ser Arg Glu Lys 
            100                 105                 110         

Val Tyr Thr Ile Pro Asp Leu Leu Gln Arg 
        115                 120         

<210>   36
<211>   877
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   36
Met Asp Lys Lys Lys Leu Leu Leu Ile Asp Gly Ser Ser Val Ala Phe 
1               5                   10                  15      

Arg Ala Phe Phe Ala Leu Tyr Gln Gln Leu Asp Arg Phe Lys Asn Val 
            20                  25                  30          

Ala Gly Leu His Thr Asn Ala Ile Tyr Gly Phe Gln Leu Met Leu Ser 
        35                  40                  45              

His Leu Leu Glu Arg Val Glu Pro Ser His Ile Leu Val Ala Phe Asp 
    50                  55                  60                  

Ala Gly Lys Thr Thr Phe Arg Thr Glu Met Tyr Ala Asp Tyr Lys Gly 
65                  70                  75                  80  

Gly Arg Ala Lys Thr Pro Asp Glu Phe Arg Glu Gln Phe Pro Phe Ile 
                85                  90                  95      

Arg Glu Leu Leu Asp His Met Gly Ile Arg His Tyr Asp Leu Ala Gln 
            100                 105                 110         

Tyr Glu Ala Asp Asp Ile Ile Gly Thr Leu Asp Lys Leu Ala Glu Gln 
        115                 120                 125             

Asp Gly Phe Asp Ile Thr Ile Val Ser Gly Asp Lys Asp Leu Ile Gln 
    130                 135                 140                 

Leu Thr Asp Glu His Thr Val Val Glu Ile Ser Lys Lys Gly Val Ala 
145                 150                 155                 160 

Glu Phe Glu Ala Phe Thr Pro Asp Tyr Leu Met Glu Glu Met Gly Leu 
                165                 170                 175     

Thr Pro Ala Gln Phe Ile Asp Leu Lys Ala Leu Met Gly Asp Lys Ser 
            180                 185                 190         

Asp Asn Ile Pro Gly Val Thr Lys Val Gly Glu Lys Thr Gly Ile Lys 
        195                 200                 205             

Leu Leu Leu Glu His Gly Ser Leu Glu Gly Ile Tyr Glu Asn Ile Asp 
    210                 215                 220                 

Gly Met Lys Thr Ser Lys Met Lys Glu Asn Leu Ile Asn Asp Lys Glu 
225                 230                 235                 240 

Gln Ala Phe Leu Ser Lys Thr Leu Ala Thr Ile Asp Thr Lys Ala Pro 
                245                 250                 255     

Ile Ala Ile Gly Leu Glu Asp Leu Val Tyr Ser Gly Pro Asp Val Glu 
            260                 265                 270         

Asn Leu Gly Lys Phe Tyr Asp Glu Met Gly Phe Lys Gln Leu Lys Gln 
        275                 280                 285             

Ala Leu Asn Val Ser Ser Ala Asp Val Ser Glu Ser Leu Asp Phe Thr 
    290                 295                 300                 

Ile Val Asp Gln Ile Ser Gln Asp Met Leu Ser Glu Glu Ser Ile Phe 
305                 310                 315                 320 

His Phe Glu Leu Phe Gly Glu Asn Tyr His Thr Asp Asn Leu Val Gly 
                325                 330                 335     

Phe Val Trp Ser Cys Gly Asp Lys Leu Tyr Ala Thr Asp Lys Leu Glu 
            340                 345                 350         

Leu Leu Gln Asp Pro Ile Phe Lys Asp Phe Leu Glu Lys Thr Ser Leu 
        355                 360                 365             

Arg Val Tyr Asp Phe Lys Lys Val Lys Val Leu Leu Gln Arg Phe Gly 
    370                 375                 380                 

Val Asp Leu Gln Ala Pro Ala Phe Asp Ile Arg Leu Ala Lys Tyr Leu 
385                 390                 395                 400 

Leu Ser Thr Val Glu Asp Asn Glu Ile Ala Thr Ile Ala Ser Leu Tyr 
                405                 410                 415     

Gly Gln Thr Tyr Leu Val Asp Asp Glu Thr Phe Tyr Gly Lys Gly Val 
            420                 425                 430         

Lys Lys Ala Ile Pro Glu Arg Glu Lys Phe Leu Glu His Leu Ala Cys 
        435                 440                 445             

Lys Leu Ala Val Leu Val Glu Thr Glu Pro Ile Leu Leu Glu Lys Leu 
    450                 455                 460                 

Ser Glu Asn Gly Gln Leu Glu Leu Leu Tyr Asp Met Glu Gln Pro Leu 
465                 470                 475                 480 

Ala Phe Val Leu Ala Lys Met Glu Ile Ala Gly Ile Met Val Lys Lys 
                485                 490                 495     

Glu Thr Leu Leu Glu Met Gln Ala Glu Asn Glu Leu Val Ile Glu Lys 
            500                 505                 510         

Leu Thr Gln Glu Ile Tyr Glu Leu Ala Gly Glu Glu Phe Asn Val Asn 
        515                 520                 525             

Ser Pro Lys Gln Leu Gly Val Leu Leu Phe Glu Lys Leu Gly Leu Pro 
    530                 535                 540                 

Leu Glu Tyr Thr Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ala Val Asp 
545                 550                 555                 560 

Val Leu Glu Arg Leu Ala Pro Ile Ala Pro Ile Val Lys Lys Ile Leu 
                565                 570                 575     

Asp Tyr Arg Gln Ile Ala Lys Ile Gln Ser Thr Tyr Val Ile Gly Leu 
            580                 585                 590         

Gln Asp Trp Ile Leu Ala Asp Gly Lys Ile His Thr Arg Tyr Val Gln 
        595                 600                 605             

Asp Leu Thr Gln Thr Gly Arg Leu Ser Ser Val Asp Pro Asn Leu Gln 
    610                 615                 620                 

Asn Ile Pro Ala Arg Leu Glu Gln Gly Arg Leu Ile Arg Lys Ala Phe 
625                 630                 635                 640 

Val Pro Glu Trp Glu Asp Ser Val Leu Leu Ser Ser Asp Tyr Ser Gln 
                645                 650                 655     

Ile Glu Leu Arg Val Leu Ala His Ile Ser Lys Asp Glu His Leu Ile 
            660                 665                 670         

Lys Ala Phe Gln Glu Gly Ala Asp Ile His Thr Ser Thr Ala Met Arg 
        675                 680                 685             

Val Phe Gly Ile Glu Arg Pro Asp Asp Val Thr Ala Asn Asp Arg Arg 
    690                 695                 700                 

Asn Ala Lys Ala Val Asn Phe Gly Val Val Tyr Gly Ile Ser Asp Phe 
705                 710                 715                 720 

Gly Leu Ser Asn Asn Leu Gly Ile Ser Arg Lys Glu Ala Lys Ala Tyr 
                725                 730                 735     

Ile Asp Thr Tyr Phe Glu Arg Phe Pro Gly Ile Lys Asn Tyr Met Asp 
            740                 745                 750         

Glu Val Val Arg Glu Ala Arg Asp Lys Gly Tyr Val Glu Thr Leu Phe 
        755                 760                 765             

Lys Arg Arg Arg Glu Leu Pro Asp Ile Asn Ser Arg Asn Phe Asn Ile 
    770                 775                 780                 

Arg Gly Phe Ala Glu Arg Thr Ala Ile Asn Ser Pro Ile Gln Gly Ser 
785                 790                 795                 800 

Ala Ala Asp Ile Leu Lys Ile Ala Met Ile Gln Leu Asp Lys Ala Leu 
                805                 810                 815     

Val Ala Gly Gly Tyr Gln Thr Lys Met Leu Leu Gln Val His Asp Glu 
            820                 825                 830         

Ile Val Leu Glu Val Pro Lys Ser Glu Leu Val Glu Met Lys Lys Leu 
        835                 840                 845             

Val Lys Gln Thr Met Glu Glu Ala Ile Gln Leu Ser Val Pro Leu Ile 
    850                 855                 860                 

Ala Asp Glu Asn Glu Gly Ala Thr Trp Tyr Glu Ala Lys 
865                 870                 875         

<210>   37
<211>   211
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   37
Met Gly Met Ala Ala Phe Lys Asn Pro Asn Asn Gln Tyr Lys Ala Ile 
1               5                   10                  15      

Thr Ile Ala Gln Thr Leu Gly Asp Asp Ala Ser Ser Glu Glu Leu Ala 
            20                  25                  30          

Gly Arg Tyr Gly Ser Ala Val Gln Cys Thr Glu Val Thr Ala Ser Asn 
        35                  40                  45              

Leu Ser Thr Val Lys Thr Lys Ala Thr Val Val Glu Lys Pro Leu Lys 
    50                  55                  60                  

Asp Phe Arg Ala Ser Thr Ser Asp Gln Ser Gly Trp Val Glu Ser Asn 
65                  70                  75                  80  

Gly Lys Trp Tyr Phe Tyr Glu Ser Gly Asp Val Lys Thr Gly Trp Val 
                85                  90                  95      

Lys Thr Asp Gly Lys Trp Tyr Tyr Leu Asn Asp Leu Gly Val Met Gln 
            100                 105                 110         

Thr Gly Phe Val Lys Phe Ser Gly Ser Trp Tyr Tyr Leu Ser Asn Ser 
        115                 120                 125             

Gly Ala Met Phe Thr Gly Trp Gly Thr Asp Gly Ser Arg Trp Phe Tyr 
    130                 135                 140                 

Phe Asp Gly Ser Gly Ala Met Lys Thr Gly Trp Tyr Lys Glu Asn Gly 
145                 150                 155                 160 

Thr Trp Tyr Tyr Leu Asp Glu Ala Gly Ile Met Lys Thr Gly Trp Phe 
                165                 170                 175     

Lys Val Gly Pro His Trp Tyr Tyr Ala Tyr Gly Ser Gly Ala Leu Ala 
            180                 185                 190         

Val Ser Thr Thr Thr Pro Asp Gly Tyr Arg Val Asn Gly Asn Gly Glu 
        195                 200                 205             

Trp Val Asn 
    210     

<210>   38
<211>   1856
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   38
Met Ser Arg Lys Ser Ile Gly Glu Lys Arg His Ser Phe Ser Met Arg 
1               5                   10                  15      

Lys Leu Ser Val Gly Leu Val Ser Val Thr Val Ser Ser Phe Phe Leu 
            20                  25                  30          

Met Ser Gln Gly Ile Gln Ser Val Ser Ala Asp Asn Met Glu Ser Pro 
        35                  40                  45              

Ile His Tyr Lys Tyr Met Thr Glu Gly Lys Leu Thr Asp Glu Glu Lys 
    50                  55                  60                  

Ser Leu Leu Val Glu Ala Leu Pro Gln Leu Ala Glu Glu Ser Asp Asp 
65                  70                  75                  80  

Thr Tyr Tyr Leu Val Tyr Arg Ser Gln Gln Phe Leu Pro Asn Thr Gly 
                85                  90                  95      

Phe Asn Pro Thr Val Gly Thr Phe Leu Phe Thr Ala Gly Leu Ser Leu 
            100                 105                 110         

Leu Val Leu Leu Val Ser Lys Arg Glu Asn Gly Lys Lys Arg Leu Val 
        115                 120                 125             

His Phe Leu Leu Leu Thr Ser Met Gly Val Gln Leu Leu Pro Ala Ser 
    130                 135                 140                 

Ala Phe Gly Leu Thr Ser Gln Ile Leu Ser Ala Tyr Asn Ser Gln Leu 
145                 150                 155                 160 

Ser Ile Gly Val Gly Glu His Leu Pro Glu Pro Leu Lys Ile Glu Gly 
                165                 170                 175     

Tyr Gln Tyr Ile Gly Tyr Ile Lys Thr Lys Lys Gln Asp Asn Thr Glu 
            180                 185                 190         

Leu Ser Arg Thr Val Asp Gly Lys Tyr Ser Ala Gln Arg Asp Ser Gln 
        195                 200                 205             

Pro Asn Ser Thr Lys Thr Ser Asp Val Val His Ser Ala Asp Leu Glu 
    210                 215                 220                 

Trp Asn Gln Gly Gln Gly Lys Val Ser Leu Gln Gly Glu Ala Ser Gly 
225                 230                 235                 240 

Asp Asp Gly Leu Ser Glu Lys Ser Ser Ile Ala Ala Asp Asn Leu Ser 
                245                 250                 255     

Ser Asn Asp Ser Phe Ala Ser Gln Val Glu Gln Asn Pro Asp His Lys 
            260                 265                 270         

Gly Glu Ser Val Val Arg Pro Thr Val Pro Glu Gln Gly Asn Pro Val 
        275                 280                 285             

Ser Ala Thr Thr Val Gln Ser Ala Glu Glu Glu Val Leu Ala Thr Thr 
    290                 295                 300                 

Asn Asp Arg Pro Glu Tyr Lys Leu Pro Leu Glu Thr Lys Gly Thr Gln 
305                 310                 315                 320 

Glu Pro Gly His Glu Gly Glu Ala Ala Val Arg Glu Asp Leu Pro Val 
                325                 330                 335     

Tyr Thr Lys Pro Leu Glu Thr Lys Gly Thr Gln Gly Pro Gly His Glu 
            340                 345                 350         

Gly Glu Ala Ala Val Arg Glu Glu Glu Pro Ala Tyr Thr Glu Pro Leu 
        355                 360                 365             

Ala Thr Lys Gly Thr Gln Glu Pro Gly His Glu Gly Lys Ala Thr Val 
    370                 375                 380                 

Arg Glu Glu Thr Leu Glu Tyr Thr Glu Pro Val Ala Thr Lys Gly Thr 
385                 390                 395                 400 

Gln Glu Pro Glu His Glu Gly Glu Ala Ala Val Glu Glu Glu Leu Pro 
                405                 410                 415     

Ala Leu Glu Val Thr Thr Arg Asn Arg Thr Glu Ile Gln Asn Ile Pro 
            420                 425                 430         

Tyr Thr Thr Glu Glu Ile Gln Asp Pro Thr Leu Leu Lys Asn Arg Arg 
        435                 440                 445             

Lys Ile Glu Arg Gln Gly Gln Ala Gly Thr Arg Thr Ile Gln Tyr Glu 
    450                 455                 460                 

Asp Tyr Ile Val Asn Gly Asn Val Val Glu Thr Lys Glu Val Ser Arg 
465                 470                 475                 480 

Thr Glu Val Ala Pro Val Asn Glu Val Val Lys Val Gly Thr Leu Val 
                485                 490                 495     

Lys Val Lys Pro Thr Val Glu Ile Thr Asn Leu Thr Lys Val Glu Asn 
            500                 505                 510         

Lys Lys Ser Ile Thr Val Ser Tyr Asn Leu Ile Asp Thr Thr Ser Ala 
        515                 520                 525             

Tyr Val Ser Ala Lys Thr Gln Val Phe His Gly Asp Lys Leu Val Lys 
    530                 535                 540                 

Glu Val Asp Ile Glu Asn Pro Ala Lys Glu Gln Val Ile Ser Gly Leu 
545                 550                 555                 560 

Asp Tyr Tyr Thr Pro Tyr Thr Val Lys Thr His Leu Thr Tyr Asn Leu 
                565                 570                 575     

Gly Glu Asn Asn Glu Glu Asn Thr Glu Thr Ser Thr Gln Asp Phe Gln 
            580                 585                 590         

Leu Glu Tyr Lys Lys Ile Glu Ile Lys Asp Ile Asp Ser Val Glu Leu 
        595                 600                 605             

Tyr Gly Lys Glu Asn Asp Arg Tyr Arg Arg Tyr Leu Ser Leu Ser Glu 
    610                 615                 620                 

Ala Pro Thr Asp Thr Ala Lys Tyr Phe Val Lys Val Lys Ser Asp Arg 
625                 630                 635                 640 

Phe Lys Glu Met Tyr Leu Pro Val Lys Ser Ile Thr Glu Asn Thr Asp 
                645                 650                 655     

Gly Thr Tyr Lys Val Thr Val Ala Val Asp Gln Leu Val Glu Glu Gly 
            660                 665                 670         

Thr Asp Gly Tyr Lys Asp Asp Tyr Thr Phe Thr Val Ala Lys Ser Lys 
        675                 680                 685             

Ala Glu Gln Pro Gly Val Tyr Thr Ser Phe Lys Gln Leu Val Thr Ala 
    690                 695                 700                 

Met Gln Ser Asn Leu Ser Gly Val Tyr Thr Leu Ala Ser Asp Met Thr 
705                 710                 715                 720 

Ala Asp Glu Val Ser Leu Gly Asp Lys Gln Thr Ser Tyr Leu Thr Gly 
                725                 730                 735     

Ala Phe Thr Gly Ser Leu Ile Gly Ser Asp Gly Thr Lys Ser Tyr Ala 
            740                 745                 750         

Ile Tyr Asp Leu Lys Lys Pro Leu Phe Asp Thr Leu Asn Gly Ala Thr 
        755                 760                 765             

Val Arg Asp Leu Asp Ile Lys Thr Val Ser Ala Asp Ser Lys Glu Asn 
    770                 775                 780                 

Val Ala Ala Leu Ala Lys Ala Ala Asn Ser Ala Asn Ile Asn Asn Val 
785                 790                 795                 800 

Ala Val Glu Gly Lys Ile Ser Gly Ala Lys Ser Val Ala Gly Leu Val 
                805                 810                 815     

Ala Ser Ala Thr Asn Thr Val Ile Glu Asn Ser Ser Phe Thr Gly Lys 
            820                 825                 830         

Leu Ile Ala Asn His Gln Asp Ser Asn Lys Asn Asp Thr Gly Gly Ile 
        835                 840                 845             

Val Gly Asn Ile Thr Gly Asn Ser Ser Arg Val Asn Lys Val Arg Val 
    850                 855                 860                 

Asp Ala Leu Ile Ser Thr Asn Ala Arg Asn Asn Asn Gln Thr Ala Gly 
865                 870                 875                 880 

Gly Ile Val Gly Arg Leu Glu Asn Gly Ala Leu Ile Ser Asn Ser Val 
                885                 890                 895     

Ala Thr Gly Glu Ile Arg Asn Gly Gln Gly Tyr Ser Arg Val Gly Gly 
            900                 905                 910         

Ile Val Gly Ser Thr Trp Gln Asn Gly Arg Val Asn Asn Val Val Ser 
        915                 920                 925             

Asn Val Asp Val Gly Asp Gly Tyr Val Ile Thr Gly Asp Gln Tyr Ala 
    930                 935                 940                 

Ala Ala Asp Val Lys Asn Ala Ser Thr Ser Val Asp Asn Arg Lys Ala 
945                 950                 955                 960 

Asp Arg Phe Ala Thr Lys Leu Ser Lys Asp Gln Ile Asp Ala Lys Val 
                965                 970                 975     

Ala Asp Tyr Gly Ile Thr Val Thr Leu Asp Asp Thr Gly Gln Asp Leu 
            980                 985                 990         

Lys Arg Asn Leu Arg Glu Val Asp Tyr Thr Arg Leu Asn Lys Ala Glu 
        995                 1000                1005            

Ala Glu Arg Lys Val Ala Tyr Ser Asn Ile Glu Lys Leu Met Pro Phe 
    1010                1015                1020                

Tyr Asn Lys Asp Leu Val Val His Tyr Gly Asn Lys Val Ala Thr Thr 
1025                1030                1035                1040

Asp Lys Leu Tyr Thr Thr Glu Leu Leu Asp Val Val Pro Met Lys Asp 
                1045                1050                1055    

Asp Glu Val Val Thr Asp Ile Asn Asn Lys Lys Asn Ser Ile Asn Lys 
            1060                1065                1070        

Val Met Leu His Phe Lys Asp Asn Thr Val Glu Tyr Leu Asp Val Thr 
        1075                1080                1085            

Phe Lys Glu Asn Phe Ile Asn Ser Gln Val Ile Glu Tyr Asn Val Thr 
    1090                1095                1100                

Gly Lys Glu Tyr Ile Phe Thr Pro Glu Ala Phe Val Ser Asp Tyr Thr 
1105                1110                1115                1120

Ala Ile Thr Asn Asn Val Leu Ser Asp Leu Gln Asn Val Thr Leu Asn 
                1125                1130                1135    

Ser Glu Ala Thr Lys Lys Val Leu Gly Ala Ala Asn Asp Ala Ala Leu 
            1140                1145                1150        

Asp Asn Leu Tyr Leu Asp Arg Gln Phe Glu Glu Val Lys Ala Asn Ile 
        1155                1160                1165            

Ala Glu His Leu Arg Lys Val Leu Ala Met Asp Lys Ser Ile Asn Thr 
    1170                1175                1180                

Thr Gly Asp Gly Val Val Glu Tyr Val Ser Glu Lys Ile Lys Asn Asn 
1185                1190                1195                1200

Lys Glu Ala Phe Met Leu Gly Leu Thr Tyr Met Asn Arg Trp Tyr Asp 
                1205                1210                1215    

Ile Asn Tyr Gly Lys Met Asn Thr Lys Asp Leu Ser Thr Tyr Lys Phe 
            1220                1225                1230        

Asp Phe Asn Gly Asn Asn Glu Thr Ser Thr Leu Asp Thr Ile Val Ala 
        1235                1240                1245            

Leu Gly Asn Ser Gly Leu Asp Asn Leu Arg Ala Ser Asn Thr Val Gly 
    1250                1255                1260                

Leu Tyr Ala Asn Lys Leu Ala Ser Val Lys Gly Glu Asp Ser Val Phe 
1265                1270                1275                1280

Asp Phe Val Glu Ala Tyr Arg Lys Leu Phe Leu Pro Asn Lys Thr Asn 
                1285                1290                1295    

Asn Glu Trp Phe Lys Glu Asn Thr Lys Ala Tyr Ile Val Glu Met Lys 
            1300                1305                1310        

Ser Asp Ile Ala Glu Val Arg Glu Lys Gln Glu Ser Pro Thr Ala Asp 
        1315                1320                1325            

Arg Lys Tyr Ser Leu Gly Val Tyr Asp Arg Ile Ser Ala Pro Ser Trp 
    1330                1335                1340                

Gly His Lys Ser Met Leu Leu Pro Leu Leu Thr Leu Pro Glu Glu Ser 
1345                1350                1355                1360

Val Tyr Ile Ser Ser Asn Met Ser Thr Leu Ala Phe Gly Ser Tyr Glu 
                1365                1370                1375    

Arg Tyr Arg Asp Ser Val Asp Gly Val Ile Leu Ser Gly Asp Ala Leu 
            1380                1385                1390        

Arg Thr Tyr Val Arg Asn Arg Val Asp Ile Ala Ala Lys Arg His Arg 
        1395                1400                1405            

Asp His Tyr Asp Ile Trp Tyr Asn Leu Leu Asp Ser Ala Ser Lys Glu 
    1410                1415                1420                

Lys Leu Phe Arg Ser Val Ile Val Tyr Asp Gly Phe Asn Val Lys Asp 
1425                1430                1435                1440

Glu Thr Gly Arg Thr Tyr Trp Ala Arg Leu Thr Asp Lys Asn Ile Gly 
                1445                1450                1455    

Ser Ile Lys Glu Phe Phe Gly Pro Val Gly Lys Trp Tyr Glu Tyr Asn 
            1460                1465                1470        

Ser Ser Ala Gly Ala Tyr Ala Asn Gly Ser Leu Thr His Phe Val Leu 
        1475                1480                1485            

Asp Arg Leu Leu Asp Ala Tyr Gly Thr Ser Val Tyr Thr His Glu Met 
    1490                1495                1500                

Val His Asn Ser Asp Ser Ala Ile Tyr Phe Glu Gly Asn Gly Arg Arg 
1505                1510                1515                1520

Glu Gly Leu Gly Ala Glu Leu Tyr Ala Leu Gly Leu Leu Gln Ser Val 
                1525                1530                1535    

Asp Ser Val Asn Ser His Ile Leu Ala Leu Asn Thr Leu Tyr Lys Ala 
            1540                1545                1550        

Glu Lys Asp Asp Leu Asn Arg Leu His Thr Tyr Asn Pro Val Glu Arg 
        1555                1560                1565            

Phe Asp Ser Asp Glu Ala Leu Gln Ser Tyr Met His Gly Ser Tyr Asp 
    1570                1575                1580                

Val Met Tyr Thr Leu Asp Ala Met Glu Ala Lys Ala Ile Leu Ala Gln 
1585                1590                1595                1600

Asn Asn Asp Val Lys Lys Lys Trp Phe Arg Lys Ile Glu Asn Tyr Tyr 
                1605                1610                1615    

Val Arg Asp Thr Arg His Asn Lys Asp Thr His Ala Gly Asn Lys Val 
            1620                1625                1630        

Arg Pro Leu Thr Asp Glu Glu Val Ala Asn Leu Thr Ser Leu Asn Ser 
        1635                1640                1645            

Leu Ile Asp Asn Asp Ile Ile Asn Arg Arg Ser Tyr Asp Asp Ser Arg 
    1650                1655                1660                

Glu Tyr Lys Arg Asn Gly Tyr Tyr Thr Ile Ser Met Phe Ser Pro Val 
1665                1670                1675                1680

Tyr Ala Ala Leu Ser Asn Ser Lys Gly Ala Pro Gly Asp Ile Met Phe 
                1685                1690                1695    

Arg Lys Ile Ala Tyr Glu Leu Leu Ala Glu Lys Gly Tyr His Lys Gly 
            1700                1705                1710        

Phe Leu Pro Tyr Val Ser Asn Gln Tyr Gly Ala Glu Ala Phe Ala Ser 
        1715                1720                1725            

Gly Ser Lys Thr Phe Ser Ser Trp His Gly Arg Asp Val Ala Leu Val 
    1730                1735                1740                

Thr Asp Asp Leu Val Phe Lys Lys Val Phe Asn Gly Glu Tyr Ser Ser 
1745                1750                1755                1760

Trp Ala Asp Phe Lys Lys Ala Met Phe Lys Gln Arg Ile Asp Lys Gln 
                1765                1770                1775    

Asp Asn Leu Lys Pro Ile Thr Ile Gln Tyr Glu Leu Gly Asn Pro Asn 
            1780                1785                1790        

Ser Thr Lys Glu Val Thr Ile Thr Thr Ala Ala Gln Met Gln Gln Leu 
        1795                1800                1805            

Ile Asn Glu Ala Ala Ala Lys Asp Ile Thr Asn Ile Asp Arg Ala Thr 
    1810                1815                1820                

Ser His Thr Pro Ala Ser Trp Val His Leu Leu Lys Gln Lys Ile Tyr 
1825                1830                1835                1840

Asn Ala Tyr Leu Arg Thr Thr Asp Asp Phe Arg Asn Ser Ile Tyr Lys 
                1845                1850                1855    


<210>   39
<211>   857
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   39
Met Lys Phe Asn Pro Asn Gln Arg Tyr Thr Arg Trp Ser Ile Arg Arg 
1               5                   10                  15      

Leu Ser Val Gly Val Ala Ser Val Val Val Ala Ser Gly Phe Phe Val 
            20                  25                  30          

Leu Val Gly Gln Pro Ser Ser Val Arg Ala Asp Gly Leu Asn Pro Thr 
        35                  40                  45              

Pro Gly Gln Val Leu Pro Glu Glu Thr Ser Gly Thr Lys Glu Gly Asp 
    50                  55                  60                  

Leu Ser Glu Lys Pro Gly Asp Thr Val Leu Thr Gln Ala Lys Pro Glu 
65                  70                  75                  80  

Gly Val Thr Gly Asn Thr Asn Ser Leu Pro Thr Pro Thr Glu Arg Thr 
                85                  90                  95      

Glu Val Ser Glu Glu Thr Ser Pro Ser Ser Leu Asp Thr Leu Phe Glu 
            100                 105                 110         

Lys Asp Glu Glu Ala Gln Lys Asn Pro Glu Leu Thr Asp Val Leu Lys 
        115                 120                 125             

Glu Thr Val Asp Thr Ala Asp Val Asp Gly Thr Gln Ala Ser Pro Ala 
    130                 135                 140                 

Glu Thr Thr Pro Glu Gln Val Lys Gly Gly Val Lys Glu Asn Thr Lys 
145                 150                 155                 160 

Asp Ser Ile Asp Val Pro Ala Ala Tyr Leu Glu Lys Ala Glu Gly Lys 
                165                 170                 175     

Gly Pro Phe Thr Ala Gly Val Asn Gln Val Ile Pro Tyr Glu Leu Phe 
            180                 185                 190         

Ala Gly Asp Gly Met Leu Thr Arg Leu Leu Leu Lys Ala Ser Asp Asn 
        195                 200                 205             

Ala Pro Trp Ser Asp Asn Gly Thr Ala Lys Asn Pro Ala Leu Pro Pro 
    210                 215                 220                 

Leu Glu Gly Leu Thr Lys Gly Lys Tyr Phe Tyr Glu Val Asp Leu Asn 
225                 230                 235                 240 

Gly Asn Thr Val Gly Lys Gln Gly Gln Ala Leu Ile Asp Gln Leu Arg 
                245                 250                 255     

Ala Asn Gly Thr Gln Thr Tyr Lys Ala Thr Val Lys Val Tyr Gly Asn 
            260                 265                 270         

Lys Asp Gly Lys Ala Asp Leu Thr Asn Leu Val Ala Thr Lys Asn Val 
        275                 280                 285             

Asp Ile Asn Ile Asn Gly Leu Val Ala Lys Glu Thr Val Gln Lys Ala 
    290                 295                 300                 

Val Ala Asp Asn Val Lys Asp Ser Ile Asp Val Pro Ala Ala Tyr Leu 
305                 310                 315                 320 

Glu Lys Ala Lys Gly Glu Gly Pro Phe Thr Ala Gly Val Asn His Val 
                325                 330                 335     

Ile Pro Tyr Glu Leu Phe Ala Gly Asp Gly Met Leu Thr Arg Leu Leu 
            340                 345                 350         

Leu Lys Ala Ser Asp Lys Ala Pro Trp Ser Asp Asn Gly Asp Ala Lys 
        355                 360                 365             

Asn Pro Ala Leu Ser Pro Leu Gly Glu Asn Val Lys Thr Lys Gly Gln 
    370                 375                 380                 

Tyr Phe Tyr Gln Val Ala Leu Asp Gly Asn Val Ala Gly Lys Glu Lys 
385                 390                 395                 400 

Gln Ala Leu Ile Asp Gln Phe Arg Ala Asn Gly Thr Gln Thr Tyr Ser 
                405                 410                 415     

Ala Thr Val Asn Val Tyr Gly Asn Lys Asp Gly Lys Pro Asp Leu Asp 
            420                 425                 430         

Asn Ile Val Ala Thr Lys Lys Val Thr Ile Asn Ile Asn Gly Leu Ile 
        435                 440                 445             

Ser Lys Glu Thr Val Gln Lys Ala Val Ala Asp Asn Val Lys Asp Ser 
    450                 455                 460                 

Ile Asp Val Pro Ala Ala Tyr Leu Glu Lys Ala Lys Gly Glu Gly Pro 
465                 470                 475                 480 

Phe Thr Ala Gly Val Asn His Val Ile Pro Tyr Glu Leu Phe Ala Gly 
                485                 490                 495     

Asp Gly Met Leu Thr Arg Leu Leu Leu Lys Ala Ser Asp Lys Ala Pro 
            500                 505                 510         

Trp Ser Asp Asn Gly Asp Ala Lys Asn Pro Ala Leu Ser Pro Leu Gly 
        515                 520                 525             

Glu Asn Val Lys Thr Lys Gly Gln Tyr Phe Tyr Gln Leu Ala Leu Asp 
    530                 535                 540                 

Gly Asn Val Ala Gly Lys Glu Lys Gln Ala Leu Ile Asp Gln Phe Arg 
545                 550                 555                 560 

Ala Asn Gly Thr Gln Thr Tyr Ser Ala Thr Val Asn Val Tyr Gly Asn 
                565                 570                 575     

Lys Asp Gly Lys Pro Asp Leu Asp Asn Ile Val Ala Thr Lys Lys Val 
            580                 585                 590         

Thr Ile Asn Ile Asn Gly Leu Ile Ser Lys Glu Thr Val Gln Lys Ala 
        595                 600                 605             

Val Ala Asp Asn Val Lys Asp Ser Ile Asp Val Pro Ala Ala Tyr Leu 
    610                 615                 620                 

Glu Lys Ala Lys Gly Glu Gly Pro Phe Thr Ala Gly Val Asn His Val 
625                 630                 635                 640 

Ile Pro Tyr Glu Leu Phe Ala Gly Asp Gly Met Leu Thr Arg Leu Leu 
                645                 650                 655     

Leu Lys Ala Ser Asp Lys Ala Pro Trp Ser Asp Asn Gly Asp Ala Lys 
            660                 665                 670         

Asn Pro Ala Leu Ser Pro Leu Gly Glu Asn Val Lys Thr Lys Gly Gln 
        675                 680                 685             

Tyr Phe Tyr Gln Val Ala Leu Asp Gly Asn Val Ala Gly Lys Glu Lys 
    690                 695                 700                 

Gln Ala Leu Ile Asp Gln Phe Arg Ala Asn Gly Thr Gln Thr Tyr Ser 
705                 710                 715                 720 

Ala Thr Val Asn Val Tyr Gly Asn Lys Asp Gly Lys Pro Asp Leu Asp 
                725                 730                 735     

Asn Ile Val Ala Thr Lys Lys Val Thr Ile Lys Ile Asn Val Lys Glu 
            740                 745                 750         

Thr Ser Asp Thr Ala Asn Gly Ser Leu Ser Pro Ser Asn Ser Gly Ser 
        755                 760                 765             

Gly Val Thr Pro Met Asn His Asn His Ala Thr Gly Thr Thr Asp Ser 
    770                 775                 780                 

Met Pro Ala Asp Thr Met Thr Ser Ser Thr Asn Thr Met Ala Gly Glu 
785                 790                 795                 800 

Asn Met Ala Ala Ser Ala Asn Lys Met Ser Asp Thr Met Met Ser Glu 
                805                 810                 815     

Asp Lys Ala Met Leu Pro Asn Thr Gly Glu Thr Gln Thr Ser Met Ala 
            820                 825                 830         

Ser Ile Gly Phe Leu Gly Leu Ala Leu Ala Gly Leu Leu Gly Gly Leu 
        835                 840                 845             

Gly Leu Lys Asn Lys Lys Glu Glu Asn 
    850                 855         

<210>   40
<211>   195
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   40
Met Lys Ser Ile Thr Lys Lys Ile Lys Ala Thr Leu Ala Gly Val Ala 
1               5                   10                  15      

Ala Leu Phe Ala Val Phe Ala Pro Ser Phe Val Ser Ala Gln Glu Ser 
            20                  25                  30          

Ser Thr Tyr Thr Val Lys Glu Gly Asp Thr Leu Ser Glu Ile Ala Glu 
        35                  40                  45              

Thr His Asn Thr Thr Val Glu Lys Leu Ala Glu Asn Asn His Ile Asp 
    50                  55                  60                  

Asn Ile His Leu Ile Tyr Val Asp Gln Glu Leu Val Ile Asp Gly Pro 
65                  70                  75                  80  

Val Ala Pro Val Ala Thr Pro Ala Pro Ala Thr Tyr Ala Ala Pro Ala 
                85                  90                  95      

Ala Gln Asp Glu Thr Val Ser Ala Pro Val Ala Glu Thr Pro Val Val 
            100                 105                 110         

Ser Glu Thr Val Val Ser Thr Val Ser Gly Ser Glu Ala Glu Ala Lys 
        115                 120                 125             

Glu Trp Ile Ala Gln Lys Glu Ser Gly Gly Ser Tyr Thr Ala Thr Asn 
    130                 135                 140                 

Gly Arg Tyr Ile Gly Arg Tyr Gln Leu Thr Asp Ser Tyr Leu Asn Gly 
145                 150                 155                 160 

Asp Tyr Ser Ala Glu Asn Gln Glu Arg Val Ala Asp Ala Tyr Val Ala 
                165                 170                 175     

Gly Arg Tyr Gly Ser Trp Thr Ala Ala Lys Asn Phe Trp Leu Asn Asn 
            180                 185                 190         

Gly Trp Tyr 
        195 

<210>   41
<211>   189
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   41
Met Lys Lys Ile Val Leu Val Ser Leu Ala Phe Leu Phe Val Leu Val 
1               5                   10                  15      

Gly Cys Gly Gln Lys Lys Glu Thr Gly Pro Ala Thr Lys Thr Glu Lys 
            20                  25                  30          

Asp Thr Leu Gln Ser Ala Leu Pro Val Ile Glu Asn Ala Glu Lys Asn 
        35                  40                  45              

Thr Val Val Thr Lys Thr Leu Val Leu Pro Lys Ser Asp Asp Gly Ser 
    50                  55                  60                  

Gln Gln Thr Gln Thr Ile Thr Tyr Lys Asp Lys Thr Phe Leu Ser Leu 
65                  70                  75                  80  

Ala Ile Gln Gln Lys Arg Pro Val Ser Asp Glu Leu Lys Thr Tyr Ile 
                85                  90                  95      

Asp Gln His Gly Val Glu Glu Thr Gln Lys Ala Leu Leu Glu Ala Glu 
            100                 105                 110         

Glu Lys Asp Lys Ser Ile Ile Glu Ala Arg Lys Leu Ala Gly Phe Lys 
        115                 120                 125             

Leu Glu Thr Lys Leu Leu Ser Ala Thr Glu Leu Gln Thr Thr Thr Ser 
    130                 135                 140                 

Phe Asp Phe Gln Val Leu Asp Val Lys Lys Ala Ser Gln Leu Glu His 
145                 150                 155                 160 

Leu Lys Asn Ile Gly Leu Glu Asn Leu Leu Lys Asn Glu Pro Ser Lys 
                165                 170                 175     

Tyr Ile Ser Asp Arg Leu Ala Asn Gly Ala Thr Glu Gln 
            180                 185                 

<210>   42
<211>   416
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   42
Met Phe Glu Val Glu Glu Trp Leu His Ser Arg Ile Gly Leu Asn Phe 
1               5                   10                  15      

Arg Ser Gly Leu Gly Arg Met Gln Gln Ala Val Asp Leu Leu Gly Asn 
            20                  25                  30          

Pro Glu Gln Ser Tyr Pro Ile Ile His Val Thr Gly Thr Asn Gly Lys 
        35                  40                  45              

Gly Ser Thr Ile Ala Phe Met Arg Glu Leu Phe Met Gly His Gly Lys 
    50                  55                  60                  

Lys Val Ala Thr Phe Thr Ser Pro His Ile Val Ser Ile Asn Asp Arg 
65                  70                  75                  80  

Ile Cys Ile Asn Gly Gln Pro Ile Ala Asp Ala Asp Phe Ile Arg Leu 
                85                  90                  95      

Thr Asp Gln Val Lys Glu Met Glu Lys Thr Leu Leu Gln Thr Pro Ala 
            100                 105                 110         

Gln Leu Ser Phe Phe Glu Leu Leu Thr Leu Val Ala Phe Leu Tyr Phe 
        115                 120                 125             

Arg Glu Gln Glu Val Asp Leu Val Leu Leu Glu Val Gly Ile Gly Gly 
    130                 135                 140                 

Leu Leu Asp Thr Thr Asn Val Val Thr Gly Glu Phe Ala Val Ile Thr 
145                 150                 155                 160 

Ser Ile Gly Leu Asp His Gln Glu Thr Leu Gly Asp Ser Leu Glu Ala 
                165                 170                 175     

Ile Ala Glu Gln Lys Ala Gly Ile Phe Lys Ala Gly Lys Lys Ala Val 
            180                 185                 190         

Ile Ala Lys Leu Pro Pro Glu Ala Arg Leu Ala Cys Gln Lys Lys Ala 
        195                 200                 205             

Glu Ser Leu Ala Val Asn Leu Tyr Gln Ala Gly Gln Asp Phe Leu Met 
    210                 215                 220                 

Leu Asn Gly Asp Phe Ser Ser Ser Leu Leu Asn Leu Ser Gln Leu Asn 
225                 230                 235                 240 

Ile Gly Leu Glu Gly Val Tyr Gln Gln Glu Asn Ala Ala Leu Ala Leu 
                245                 250                 255     

Gln Thr Phe Leu Leu Phe Met Arg Glu Arg Lys Glu Ala Val Asp Glu 
            260                 265                 270         

Gln Ala Val Arg Lys Ala Leu Glu Gln Thr His Trp Ala Gly Arg Leu 
        275                 280                 285             

Glu Arg Ile Arg Pro Gln Ile Tyr Leu Asp Gly Ala His Asn Leu Pro 
    290                 295                 300                 

Ala Leu Thr Arg Leu Ala Glu Phe Ile Lys Glu Lys Glu Gln Glu Gly 
305                 310                 315                 320 

Tyr Arg Pro Gln Ile Leu Phe Gly Ser Leu Lys Arg Lys Asp Tyr Gln 
                325                 330                 335     

Gly Met Leu Gly Tyr Leu Thr Glu Lys Leu Pro Gln Val Glu Leu Lys 
            340                 345                 350         

Val Thr Gly Phe Asp Tyr Gln Gly Ala Leu Asp Glu Arg Asp Val Thr 
        355                 360                 365             

Gly Tyr Asp Ile Val Ser Ser Tyr Arg Glu Phe Ile Ser Asp Phe Glu 
    370                 375                 380                 

Glu Arg Ala Asp Ala Gln Asp Leu Leu Phe Val Thr Gly Ser Leu Tyr 
385                 390                 395                 400 

Phe Ile Ser Glu Val Arg Gly Tyr Leu Leu Asp Arg Glu Gln Ile Asn 
                405                 410                 415     


<210>   43
<211>   277
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   43
Val Gly Ile Arg Val Tyr Lys Pro Thr Thr Asn Gly Arg Arg Asn Met 
1               5                   10                  15      

Thr Ser Leu Asp Phe Ala Glu Ile Thr Thr Ser Thr Pro Glu Lys Ser 
            20                  25                  30          

Leu Leu Val Ala Leu Lys Ser Lys Ala Gly Arg Asn Asn Asn Gly Arg 
        35                  40                  45              

Ile Thr Val Arg His Gln Gly Gly Gly His Lys Arg Phe Tyr Arg Leu 
    50                  55                  60                  

Val Asp Phe Lys Arg Asn Lys Asp Asn Val Glu Ala Val Val Lys Thr 
65                  70                  75                  80  

Ile Glu Tyr Asp Pro Asn Arg Ser Ala Asn Ile Ala Leu Val His Tyr 
                85                  90                  95      

Thr Asp Gly Val Lys Ala Tyr Ile Ile Ala Pro Lys Gly Leu Glu Val 
            100                 105                 110         

Gly Gln Arg Ile Val Ser Gly Pro Glu Ala Asp Ile Lys Val Gly Asn 
        115                 120                 125             

Ala Leu Pro Leu Ala Asn Ile Pro Val Gly Thr Leu Ile His Asn Ile 
    130                 135                 140                 

Glu Leu Lys Pro Gly Arg Gly Gly Glu Leu Val Arg Ala Ala Gly Ala 
145                 150                 155                 160 

Ser Ala Gln Val Leu Gly Ser Glu Gly Lys Tyr Val Leu Val Arg Leu 
                165                 170                 175     

Gln Ser Gly Glu Val Arg Met Ile Leu Gly Thr Cys Arg Ala Thr Val 
            180                 185                 190         

Gly Val Val Gly Asn Glu Gln His Gly Leu Val Asn Leu Gly Lys Ala 
        195                 200                 205             

Gly Arg Ser Arg Trp Lys Gly Ile Arg Pro Thr Val Arg Gly Ser Val 
    210                 215                 220                 

Met Asn Pro Asn Asp His Pro His Gly Gly Gly Glu Gly Lys Ala Pro 
225                 230                 235                 240 

Val Gly Arg Lys Ala Pro Ser Thr Pro Trp Gly Lys Pro Ala Leu Gly 
                245                 250                 255     

Leu Lys Thr Arg Asn Lys Lys Ala Lys Ser Asp Lys Leu Ile Val Arg 
            260                 265                 270         

Arg Arg Asn Glu Lys 
        275         

<210>   44
<211>   89
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   44
Met Ala Lys Lys Ser Met Val Ala Arg Glu Ala Lys Arg Gln Lys Ile 
1               5                   10                  15      

Val Asp Arg Tyr Ala Glu Lys Arg Ala Ala Leu Lys Ala Ala Gly Asp 
            20                  25                  30          

Tyr Glu Gly Leu Ser Lys Leu Pro Arg Asn Ala Ser Pro Thr Arg Leu 
        35                  40                  45              

His Asn Arg Cys Arg Val Thr Gly Arg Pro His Ser Val Tyr Arg Lys 
    50                  55                  60                  

Phe Gly Leu Ser Arg Ile Ala Phe Arg Glu Leu Ala His Lys Gly Gln 
65                  70                  75                  80  

Ile Pro Gly Val Thr Lys Ala Ser Trp 
                85                  

<210>   45
<211>   445
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   45
Met Asp Ile Arg Gln Val Thr Glu Thr Ile Ala Met Ile Glu Glu Gln 
1               5                   10                  15      

Asn Phe Asp Ile Arg Thr Ile Thr Met Gly Ile Ser Leu Leu Asp Cys 
            20                  25                  30          

Ile Asp Pro Asp Ile Asn Arg Ala Ala Glu Lys Ile Tyr Gln Lys Ile 
        35                  40                  45              

Thr Thr Lys Ala Ala Asn Leu Val Ala Val Gly Asp Glu Ile Ala Ala 
    50                  55                  60                  

Glu Leu Gly Ile Pro Ile Val Asn Lys Arg Val Ser Val Thr Pro Ile 
65                  70                  75                  80  

Ser Leu Ile Gly Ala Ala Thr Asp Ala Thr Asp Tyr Val Val Leu Ala 
                85                  90                  95      

Lys Ala Leu Asp Lys Ala Ala Lys Glu Ile Gly Val Asp Phe Ile Gly 
            100                 105                 110         

Gly Phe Ser Ala Leu Val Gln Lys Gly Tyr Gln Lys Gly Asp Glu Ile 
        115                 120                 125             

Leu Ile Asn Ser Ile Pro Arg Ala Leu Ala Glu Thr Asp Lys Val Cys 
    130                 135                 140                 

Ser Ser Val Asn Ile Gly Ser Thr Lys Ser Gly Ile Asn Met Thr Ala 
145                 150                 155                 160 

Val Ala Asp Met Gly Arg Ile Ile Lys Glu Thr Ala Asn Leu Ser Asp 
                165                 170                 175     

Met Gly Val Ala Lys Leu Val Val Phe Ala Asn Ala Val Glu Asp Asn 
            180                 185                 190         

Pro Phe Met Ala Gly Ala Phe His Gly Val Gly Glu Ala Asp Val Ile 
        195                 200                 205             

Ile Asn Val Gly Val Ser Gly Pro Gly Val Val Lys Arg Ala Leu Glu 
    210                 215                 220                 

Lys Val Arg Gly Gln Ser Phe Asp Val Val Ala Glu Thr Val Lys Lys 
225                 230                 235                 240 

Thr Ala Phe Lys Ile Thr Arg Ile Gly Gln Leu Val Gly Gln Met Ala 
                245                 250                 255     

Ser Glu Arg Leu Gly Val Glu Phe Gly Ile Val Asp Leu Ser Leu Ala 
            260                 265                 270         

Pro Thr Pro Ala Val Gly Asp Ser Val Ala Arg Val Leu Glu Glu Met 
        275                 280                 285             

Gly Leu Glu Thr Val Gly Thr His Gly Thr Thr Ala Ala Leu Ala Leu 
    290                 295                 300                 

Leu Asn Asp Gln Val Lys Lys Gly Gly Val Met Ala Cys Asn Gln Val 
305                 310                 315                 320 

Gly Gly Leu Ser Gly Ala Phe Ile Pro Val Ser Glu Asp Glu Gly Met 
                325                 330                 335     

Ile Ala Ala Val Gln Asn Gly Ser Leu Asn Leu Glu Lys Leu Glu Ala 
            340                 345                 350         

Met Thr Ala Ile Cys Ser Val Gly Leu Asp Met Ile Ala Ile Pro Glu 
        355                 360                 365             

Asp Thr Pro Ala Glu Thr Ile Ala Ala Met Ile Ala Asp Glu Ala Ala 
    370                 375                 380                 

Ile Gly Val Ile Asn Met Lys Thr Thr Ala Val Arg Ile Ile Pro Lys 
385                 390                 395                 400 

Gly Lys Glu Gly Asp Met Ile Glu Phe Gly Gly Leu Leu Gly Thr Ala 
                405                 410                 415     

Pro Val Met Lys Val Asn Gly Ala Ser Ser Val Asp Phe Ile Ser Arg 
            420                 425                 430         

Gly Gly Gln Ile Pro Ala Pro Ile His Ser Phe Lys Asn 
        435                 440                 445 

<210>   46
<211>   812
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   46
Met Val Asn Thr Glu Val Ala Arg Thr Thr Ile Lys Thr Glu Tyr Phe 
1               5                   10                  15      

Gly Ser Leu Thr Glu Arg Met Asn Lys Tyr Arg Glu Asp Val Leu Asn 
            20                  25                  30          

Lys Lys Pro Tyr Ile Asp Ala Glu Arg Ala Val Leu Ala Thr Arg Ala 
        35                  40                  45              

Tyr Glu Arg Tyr Lys Glu Gln Pro Asn Val Leu Lys Arg Ala Tyr Met 
    50                  55                  60                  

Leu Lys Glu Ile Leu Glu Asn Met Thr Ile Tyr Ile Glu Glu Glu Ser 
65                  70                  75                  80  

Met Ile Ala Gly Asn Gln Ala Ser Ser Asn Lys Asp Ala Pro Ile Phe 
                85                  90                  95      

Pro Glu Tyr Thr Leu Glu Phe Val Leu Asn Glu Leu Asp Leu Phe Glu 
            100                 105                 110         

Lys Arg Asp Gly Asp Val Phe Tyr Ile Thr Glu Glu Thr Lys Glu Gln 
        115                 120                 125             

Leu Arg Ser Ile Ala Pro Phe Trp Glu Asn Asn Asn Leu Arg Ala Arg 
    130                 135                 140                 

Ala Gly Ala Leu Leu Pro Glu Glu Val Ser Val Tyr Met Glu Thr Gly 
145                 150                 155                 160 

Phe Phe Gly Met Glu Gly Lys Met Asn Ser Gly Asp Ala His Leu Ala 
                165                 170                 175     

Val Asn Tyr Gln Lys Leu Leu Gln Phe Gly Leu Arg Gly Phe Glu Glu 
            180                 185                 190         

Arg Ala Arg Lys Ala Lys Val Ala Leu Asp Leu Thr Asp Pro Ala Ser 
        195                 200                 205             

Ile Asp Lys Tyr His Phe Tyr Asp Ser Ile Phe Ile Val Ile Asp Ala 
    210                 215                 220                 

Ile Lys Val Tyr Ala Lys Arg Phe Val Ala Leu Ala Lys Ser Leu Ala 
225                 230                 235                 240 

Glu Asn Ala Asn Pro Lys Arg Lys Lys Glu Leu Leu Glu Ile Ala Asp 
                245                 250                 255     

Ile Cys Ser Arg Val Pro Tyr Glu Pro Ala Thr Thr Phe Ala Glu Ala 
            260                 265                 270         

Ile Gln Ser Val Trp Phe Ile Gln Cys Ile Leu Gln Ile Glu Ser Asn 
        275                 280                 285             

Gly His Ser Leu Ser Tyr Gly Arg Phe Asp Gln Tyr Met Tyr Pro Tyr 
    290                 295                 300                 

Met Lys Ala Asp Leu Glu Ser Gly Lys Glu Thr Glu Asp Ser Ile Val 
305                 310                 315                 320 

Glu Arg Leu Thr Asn Leu Trp Ile Lys Thr Ile Thr Ile Asn Lys Val 
                325                 330                 335     

Arg Ser Gln Ser His Thr Phe Ser Ser Ala Gly Ser Pro Leu Tyr Gln 
            340                 345                 350         

Asn Val Thr Ile Gly Gly Gln Thr Arg Asp Lys Lys Asp Ala Val Asn 
        355                 360                 365             

Pro Leu Ser Tyr Leu Val Leu Lys Ser Val Ala Gln Thr His Leu Pro 
    370                 375                 380                 

Gln Pro Asn Leu Thr Val Arg Tyr His Ala Gly Leu Asp Ala Arg Phe 
385                 390                 395                 400 

Met Asn Glu Cys Ile Glu Val Met Lys Leu Gly Phe Gly Met Pro Ala 
                405                 410                 415     

Phe Asn Asn Asp Glu Ile Ile Ile Pro Ser Phe Ile Ala Lys Gly Val 
            420                 425                 430         

Leu Glu Asp Asp Ala Tyr Asp Tyr Ser Ala Ile Gly Cys Val Glu Thr 
        435                 440                 445             

Ala Val Pro Gly Lys Trp Gly Tyr Arg Cys Thr Gly Met Ser Tyr Met 
    450                 455                 460                 

Asn Phe Pro Lys Val Leu Leu Ile Thr Met Asn Asp Gly Ile Asp Pro 
465                 470                 475                 480 

Ala Ser Gly Lys Arg Phe Ala Pro Ser Phe Gly Arg Phe Lys Asp Met 
                485                 490                 495     

Lys Asn Phe Ser Glu Leu Glu Asn Ala Trp Asp Lys Thr Leu Arg Tyr 
            500                 505                 510         

Leu Thr Arg Met Ser Val Ile Val Glu Asn Ser Ile Asp Leu Ser Leu 
        515                 520                 525             

Glu Arg Glu Val Pro Asp Ile Leu Cys Ser Ala Leu Thr Asp Asp Cys 
    530                 535                 540                 

Ile Gly Arg Gly Lys His Leu Lys Glu Gly Gly Ala Val Tyr Asp Tyr 
545                 550                 555                 560 

Ile Ser Gly Leu Gln Val Gly Ile Ala Asn Leu Ser Asp Ser Leu Ala 
                565                 570                 575     

Ala Ile Lys Lys Leu Val Phe Glu Glu Glu Arg Ile Ser Pro Ser Gln 
            580                 585                 590         

Leu Trp His Ala Leu Glu Thr Asp Tyr Ala Gly Glu Glu Gly Lys Val 
        595                 600                 605             

Ile Gln Glu Met Leu Ile His Asp Ala Pro Lys Tyr Gly Asn Asp Asp 
    610                 615                 620                 

Asp Tyr Ala Asp Lys Leu Val Thr Ala Ala Tyr Asp Ile Tyr Val Asp 
625                 630                 635                 640 

Glu Ile Ala Lys Tyr Pro Asn Thr Arg Tyr Gly Arg Gly Pro Ile Gly 
                645                 650                 655     

Gly Ile Arg Tyr Ser Gly Thr Ser Ser Ile Ser Ala Asn Val Gly Gln 
            660                 665                 670         

Gly Arg Gly Thr Leu Ala Thr Pro Asp Gly Arg Asn Ala Gly Thr Pro 
        675                 680                 685             

Leu Ala Glu Gly Cys Ser Pro Ser His Asn Met Asp Gln His Gly Pro 
    690                 695                 700                 

Thr Ser Val Leu Lys Ser Val Ser Lys Leu Pro Thr Asp Glu Ile Val 
705                 710                 715                 720 

Gly Gly Val Leu Leu Asn Gln Lys Val Asn Pro Gln Thr Leu Ala Lys 
                725                 730                 735     

Glu Glu Asp Lys Leu Lys Leu Ile Ala Leu Leu Arg Thr Phe Phe Asn 
            740                 745                 750         

Arg Leu His Gly Tyr His Ile Gln Tyr Asn Val Val Ser Arg Glu Thr 
        755                 760                 765             

Leu Ile Asp Ala Gln Lys His Pro Glu Lys His Arg Asp Leu Ile Val 
    770                 775                 780                 

Arg Val Ala Gly Tyr Ser Ala Phe Phe Asn Val Leu Ser Lys Ala Thr 
785                 790                 795                 800 

Gln Asp Asp Ile Ile Gly Arg Thr Glu His Thr Leu 
                805                 810         

<210>   47
<211>   130
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   47
Met Ser Gln Ala Gln Tyr Ala Gly Thr Gly Arg Arg Lys Asn Ala Val 
1               5                   10                  15      

Ala Arg Val Arg Leu Val Pro Gly Thr Gly Lys Ile Thr Val Asn Lys 
            20                  25                  30          

Lys Asp Val Glu Glu Tyr Ile Pro His Ala Asp Leu Arg Leu Val Ile 
        35                  40                  45              

Asn Gln Pro Phe Ala Val Thr Ser Thr Val Gly Ser Tyr Asp Val Phe 
    50                  55                  60                  

Val Asn Val Ile Gly Gly Gly Tyr Ala Gly Gln Ser Gly Ala Ile Arg 
65                  70                  75                  80  

His Gly Ile Ala Arg Ala Leu Leu Gln Val Asp Pro Asp Phe Arg Asp 
                85                  90                  95      

Ser Leu Lys Arg Ala Gly Leu Leu Thr Arg Asp Ser Arg Lys Val Glu 
            100                 105                 110         

Arg Lys Lys Pro Gly Leu Lys Lys Ala Arg Lys Ala Ser Gln Phe Ser 
        115                 120                 125             

Lys Arg 
    130 

<210>   48
<211>   333
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   48
Leu Glu Lys Lys Leu Thr Ile Lys Asp Ile Ala Glu Met Ala Gln Thr 
1               5                   10                  15      

Ser Lys Thr Thr Val Ser Phe Tyr Leu Asn Gly Lys Tyr Glu Lys Met 
            20                  25                  30          

Ser Gln Glu Thr Arg Glu Lys Ile Glu Lys Val Ile His Glu Thr Asn 
        35                  40                  45              

Tyr Lys Pro Ser Ile Val Ala Arg Ser Leu Asn Ser Lys Arg Thr Lys 
    50                  55                  60                  

Leu Ile Gly Val Leu Ile Gly Asp Ile Thr Asn Ser Phe Ser Asn Gln 
65                  70                  75                  80  

Ile Val Lys Gly Ile Glu Asp Ile Ala Ser Gln Asn Gly Tyr Gln Val 
                85                  90                  95      

Met Ile Gly Asn Ser Asn Tyr Ser Gln Glu Ser Glu Asp Arg Tyr Ile 
            100                 105                 110         

Glu Ser Met Leu Leu Leu Gly Val Asp Gly Phe Ile Ile Gln Pro Thr 
        115                 120                 125             

Ser Asn Phe Arg Lys Tyr Ser Arg Ile Ile Asp Glu Lys Lys Lys Lys 
    130                 135                 140                 

Met Val Phe Phe Asp Ser Gln Leu Tyr Glu His Arg Thr Ser Trp Val 
145                 150                 155                 160 

Lys Thr Asn Asn Tyr Asp Ala Val Tyr Asp Met Thr Gln Ser Cys Ile 
                165                 170                 175     

Glu Lys Gly Tyr Glu His Phe Leu Leu Ile Thr Ala Asp Thr Ser Arg 
            180                 185                 190         

Leu Ser Thr Arg Ile Glu Arg Ala Ser Gly Phe Val Asp Ala Leu Thr 
        195                 200                 205             

Asp Ala Asn Met Arg His Ala Ser Leu Thr Ile Glu Asp Lys His Thr 
    210                 215                 220                 

Asn Leu Glu Gln Ile Lys Glu Phe Leu Gln Lys Glu Ile Asp Pro Asp 
225                 230                 235                 240 

Glu Lys Thr Leu Val Phe Ile Pro Asn Cys Trp Ala Leu Pro Leu Val 
                245                 250                 255     

Phe Thr Val Ile Lys Glu Leu Asn Tyr Asn Leu Pro Gln Val Gly Leu 
            260                 265                 270         

Ile Gly Phe Asp Asn Thr Glu Trp Thr Cys Phe Ser Ser Pro Ser Val 
        275                 280                 285             

Ser Thr Leu Val Gln Pro Ser Phe Glu Glu Gly Gln Gln Ala Thr Lys 
    290                 295                 300                 

Ile Leu Ile Asp Gln Ile Glu Gly Arg Asn Gln Glu Glu Arg Gln Gln 
305                 310                 315                 320 

Val Leu Asp Cys Ser Val Asn Trp Lys Glu Ser Thr Phe 
                325                 330             

<210>   49
<211>   1767
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   49
Met Asn Lys Gly Leu Phe Glu Lys Arg Cys Lys Tyr Ser Ile Arg Lys 
1               5                   10                  15      

Phe Ser Leu Gly Val Ala Ser Val Met Ile Gly Ala Ala Phe Phe Gly 
            20                  25                  30          

Thr Ser Pro Val Leu Ala Asp Ser Val Gln Ser Gly Ser Thr Ala Asn 
        35                  40                  45              

Leu Pro Ala Asp Leu Ala Thr Ala Leu Ala Thr Ala Lys Glu Asn Asp 
    50                  55                  60                  

Gly Arg Asp Phe Glu Ala Pro Lys Val Gly Glu Asp Gln Gly Ser Pro 
65                  70                  75                  80  

Glu Val Thr Asp Gly Pro Lys Thr Glu Glu Glu Leu Leu Ala Leu Glu 
                85                  90                  95      

Lys Glu Lys Pro Ala Glu Glu Lys Pro Lys Glu Asp Lys Pro Ala Ala 
            100                 105                 110         

Ala Lys Pro Glu Thr Pro Lys Thr Val Thr Pro Glu Trp Gln Thr Val 
        115                 120                 125             

Ala Asn Lys Glu Gln Gln Gly Thr Val Thr Ile Arg Glu Glu Lys Gly 
    130                 135                 140                 

Val Arg Tyr Asn Gln Leu Ser Ser Thr Ala Gln Asn Asp Asn Ala Gly 
145                 150                 155                 160 

Lys Pro Ala Leu Phe Glu Lys Lys Gly Leu Thr Val Asp Ala Asn Gly 
                165                 170                 175     

Asn Ala Thr Val Asp Leu Thr Phe Lys Asp Asp Ser Glu Lys Gly Lys 
            180                 185                 190         

Ser Arg Phe Gly Val Phe Leu Lys Phe Lys Asp Thr Lys Asn Asn Val 
        195                 200                 205             

Phe Val Gly Tyr Asp Lys Asp Gly Trp Phe Trp Glu Tyr Lys Ser Pro 
    210                 215                 220                 

Thr Thr Ser Thr Trp Tyr Arg Gly Ser Arg Val Ala Ala Pro Glu Thr 
225                 230                 235                 240 

Gly Ser Thr Asn Arg Leu Ser Ile Thr Leu Lys Ser Asp Gly Gln Leu 
                245                 250                 255     

Asn Ala Ser Asn Asn Asp Val Asn Leu Phe Asp Thr Val Thr Leu Pro 
            260                 265                 270         

Ala Ala Val Asn Asp His Leu Lys Asn Glu Lys Lys Ile Leu Leu Lys 
        275                 280                 285             

Ala Gly Ser Tyr Asp Asp Glu Arg Thr Val Val Ser Val Lys Thr Asp 
    290                 295                 300                 

Asn Gln Glu Gly Val Lys Thr Glu Asp Thr Pro Ala Glu Lys Glu Thr 
305                 310                 315                 320 

Gly Pro Glu Val Asp Asp Ser Lys Val Thr Tyr Asp Thr Ile Gln Ser 
                325                 330                 335     

Lys Val Leu Lys Ala Val Ile Asp Gln Ala Phe Pro Arg Val Lys Glu 
            340                 345                 350         

Tyr Ser Leu Asn Gly His Thr Leu Pro Gly Gln Val Gln Gln Phe Asn 
        355                 360                 365             

Gln Val Phe Ile Asn Asn His Arg Ile Thr Pro Glu Val Thr Tyr Lys 
    370                 375                 380                 

Lys Ile Asn Glu Thr Thr Ala Glu Tyr Leu Met Lys Leu Arg Asp Asp 
385                 390                 395                 400 

Ala His Leu Ile Asn Ala Glu Met Thr Val Arg Leu Gln Val Val Asp 
                405                 410                 415     

Asn Gln Leu His Phe Asp Val Thr Lys Ile Val Asn His Asn Gln Val 
            420                 425                 430         

Thr Pro Gly Gln Lys Ile Asp Asp Glu Ser Lys Leu Leu Ser Ser Ile 
        435                 440                 445             

Ser Phe Leu Gly Asn Ala Leu Val Ser Val Ser Ser Asn Gln Thr Gly 
    450                 455                 460                 

Ala Lys Phe Asp Gly Ala Thr Met Ser Asn Asn Thr His Val Ser Gly 
465                 470                 475                 480 

Asp Asp His Ile Asp Val Thr Asn Pro Met Lys Asp Leu Ala Lys Gly 
                485                 490                 495     

Tyr Met Tyr Gly Phe Val Ser Thr Asp Lys Leu Ala Ala Gly Val Trp 
            500                 505                 510         

Ser Asn Ser Gln Asn Ser Tyr Gly Gly Gly Ser Asn Asp Trp Thr Arg 
        515                 520                 525             

Leu Thr Ala Tyr Lys Glu Thr Val Gly Asn Ala Asn Tyr Val Gly Ile 
    530                 535                 540                 

His Ser Ser Glu Trp Gln Trp Glu Lys Ala Tyr Lys Gly Ile Val Phe 
545                 550                 555                 560 

Pro Glu Tyr Thr Lys Glu Leu Pro Ser Ala Lys Val Val Ile Thr Glu 
                565                 570                 575     

Asp Ala Asn Ala Asp Lys Asn Val Asp Trp Gln Asp Gly Ala Ile Ala 
            580                 585                 590         

Tyr Arg Ser Ile Met Asn Asn Pro Gln Gly Trp Glu Lys Val Lys Asp 
        595                 600                 605             

Ile Thr Ala Tyr Arg Ile Ala Met Asn Phe Gly Ser Gln Ala Gln Asn 
    610                 615                 620                 

Pro Phe Leu Met Thr Leu Asp Gly Ile Lys Lys Ile Asn Leu His Thr 
625                 630                 635                 640 

Asp Gly Leu Gly Gln Gly Val Leu Leu Lys Gly Tyr Gly Ser Glu Gly 
                645                 650                 655     

His Asp Ser Gly His Leu Asn Tyr Ala Asp Ile Gly Lys Arg Ile Gly 
            660                 665                 670         

Gly Val Glu Asp Phe Lys Thr Leu Ile Glu Lys Ala Lys Lys Tyr Gly 
        675                 680                 685             

Ala His Leu Gly Ile His Val Asn Ala Ser Glu Thr Tyr Pro Glu Ser 
    690                 695                 700                 

Lys Tyr Phe Asn Glu Lys Ile Leu Arg Lys Asn Pro Asp Gly Ser Tyr 
705                 710                 715                 720 

Ser Tyr Gly Trp Asn Trp Leu Asp Gln Gly Ile Asn Ile Asp Ala Ala 
                725                 730                 735     

Tyr Asp Leu Ala His Gly Arg Leu Ala Arg Trp Glu Asp Leu Lys Lys 
            740                 745                 750         

Lys Leu Gly Asp Gly Leu Asp Phe Ile Tyr Val Asp Val Trp Gly Asn 
        755                 760                 765             

Gly Gln Ser Gly Asp Asn Gly Ala Trp Ala Thr His Val Leu Ala Lys 
    770                 775                 780                 

Glu Ile Asn Lys Gln Gly Trp Arg Phe Ala Ile Glu Trp Gly His Gly 
785                 790                 795                 800 

Gly Glu Tyr Asp Ser Thr Phe His His Trp Ala Ala Asp Leu Thr Tyr 
                805                 810                 815     

Gly Gly Tyr Thr Asn Lys Gly Ile Asn Ser Ala Ile Thr Arg Phe Ile 
            820                 825                 830         

Arg Asn His Gln Lys Asp Ala Trp Val Gly Asp Tyr Arg Ser Tyr Gly 
        835                 840                 845             

Gly Ala Ala Asn Tyr Pro Leu Leu Gly Gly Tyr Ser Met Lys Asp Phe 
    850                 855                 860                 

Glu Gly Trp Gln Gly Arg Ser Asp Tyr Asn Gly Tyr Val Thr Asn Leu 
865                 870                 875                 880 

Phe Ala His Asp Val Met Thr Lys Tyr Phe Gln His Phe Thr Val Ser 
                885                 890                 895     

Lys Trp Glu Asn Gly Thr Pro Val Thr Met Thr Asp Asn Gly Ser Thr 
            900                 905                 910         

Tyr Lys Trp Thr Pro Glu Met Arg Val Glu Leu Val Asp Ala Asp Asn 
        915                 920                 925             

Asn Lys Val Val Val Thr Arg Lys Ser Asn Asp Val Asn Ser Pro Gln 
    930                 935                 940                 

Tyr Arg Glu Arg Thr Val Thr Leu Asn Gly Arg Val Ile Gln Asp Gly 
945                 950                 955                 960 

Ser Ala Tyr Leu Thr Pro Trp Asn Trp Asp Ala Asn Gly Lys Lys Leu 
                965                 970                 975     

Ser Thr Asp Lys Glu Lys Met Tyr Tyr Phe Asn Thr Gln Ala Gly Ala 
            980                 985                 990         

Thr Thr Trp Thr Leu Pro Ser Asp Trp Ala Lys Ser Lys Val Tyr Leu 
        995                 1000                1005            

Tyr Lys Leu Thr Asp Gln Gly Lys Thr Glu Glu Gln Glu Leu Thr Val 
    1010                1015                1020                

Lys Asp Gly Lys Ile Thr Leu Asp Leu Leu Ala Asn Gln Pro Tyr Val 
1025                1030                1035                1040

Leu Tyr Arg Ser Lys Gln Thr Asn Pro Glu Met Ser Trp Ser Glu Gly 
                1045                1050                1055    

Met His Ile Tyr Asp Gln Gly Phe Asn Ser Gly Thr Leu Lys His Trp 
            1060                1065                1070        

Thr Ile Ser Gly Asp Ala Ser Lys Ala Glu Ile Val Lys Ser Gln Gly 
        1075                1080                1085            

Ala Asn Asp Met Leu Arg Ile Gln Gly Asn Lys Glu Lys Val Ser Leu 
    1090                1095                1100                

Thr Gln Lys Leu Thr Gly Leu Lys Pro Asn Thr Lys Tyr Ala Val Tyr 
1105                1110                1115                1120

Val Gly Val Asp Asn Arg Ser Asn Ala Lys Ala Ser Ile Thr Val Asn 
                1125                1130                1135    

Thr Gly Glu Lys Glu Val Thr Thr Tyr Thr Asn Lys Ser Leu Ala Leu 
            1140                1145                1150        

Asn Tyr Val Lys Ala Tyr Ala His Asn Thr Arg Arg Asp Asn Ala Thr 
        1155                1160                1165            

Val Asp Asp Thr Ser Tyr Phe Gln Asn Met Tyr Ala Phe Phe Thr Thr 
    1170                1175                1180                

Gly Ala Asp Val Ser Asn Val Thr Leu Thr Leu Ser Arg Glu Ala Gly 
1185                1190                1195                1200

Asp Gln Ala Thr Tyr Phe Asp Glu Ile Arg Thr Phe Glu Asn Asn Ser 
                1205                1210                1215    

Ser Met Tyr Gly Asp Lys His Asp Thr Gly Lys Gly Thr Phe Lys Gln 
            1220                1225                1230        

Asp Phe Glu Asn Val Ala Gln Gly Ile Phe Pro Phe Val Val Gly Gly 
        1235                1240                1245            

Val Glu Gly Val Glu Asp Asn Arg Thr His Leu Ser Glu Lys His Asn 
    1250                1255                1260                

Pro Tyr Thr Gln Arg Gly Trp Asn Gly Lys Lys Val Asp Asp Val Ile 
1265                1270                1275                1280

Glu Gly Asn Trp Ser Leu Lys Thr Asn Gly Leu Val Ser Arg Arg Asn 
                1285                1290                1295    

Leu Val Tyr Gln Thr Ile Pro Gln Asn Phe Arg Phe Glu Ala Gly Lys 
            1300                1305                1310        

Thr Tyr Arg Val Thr Phe Glu Tyr Glu Ala Gly Ser Asp Asn Thr Tyr 
        1315                1320                1325            

Ala Phe Val Val Gly Lys Gly Glu Phe Gln Ser Gly Arg Arg Gly Thr 
    1330                1335                1340                

Gln Ala Ser Asn Leu Glu Met His Glu Leu Pro Asn Thr Trp Thr Asp 
1345                1350                1355                1360

Ser Lys Lys Ala Lys Lys Ala Thr Phe Leu Val Thr Gly Ala Glu Thr 
                1365                1370                1375    

Gly Asp Thr Trp Val Gly Ile Tyr Ser Thr Gly Asn Ala Ser Asn Thr 
            1380                1385                1390        

Arg Gly Asp Ser Gly Gly Asn Ala Asn Phe Arg Gly Tyr Asn Asp Phe 
        1395                1400                1405            

Met Met Asp Asn Leu Gln Ile Glu Glu Ile Thr Leu Thr Gly Lys Met 
    1410                1415                1420                

Leu Thr Glu Asn Ala Leu Lys Asn Tyr Leu Pro Thr Val Ala Met Thr 
1425                1430                1435                1440

Asn Tyr Thr Lys Glu Ser Met Asp Ala Leu Lys Glu Ala Val Phe Asn 
                1445                1450                1455    

Leu Ser Gln Ala Asp Asp Asp Ile Ser Val Glu Glu Ala Arg Ala Glu 
            1460                1465                1470        

Ile Ala Lys Ile Glu Ala Leu Lys Asn Ala Leu Val Gln Lys Lys Thr 
        1475                1480                1485            

Ala Leu Val Ala Asp Asp Phe Ala Ser Leu Thr Ala Pro Ala Gln Ala 
    1490                1495                1500                

Gln Glu Gly Leu Ala Asn Ala Phe Asp Gly Asn Val Ser Ser Leu Trp 
1505                1510                1515                1520

His Thr Ser Trp Asn Gly Gly Asp Val Gly Lys Pro Ala Thr Met Val 
                1525                1530                1535    

Leu Lys Glu Pro Thr Glu Ile Thr Gly Leu Arg Tyr Val Pro Arg Gly 
            1540                1545                1550        

Ser Gly Ser Asn Gly Asn Leu Arg Asp Val Lys Leu Val Val Thr Asp 
        1555                1560                1565            

Glu Ser Gly Lys Glu His Thr Phe Thr Ala Thr Asp Trp Pro Asn Asn 
    1570                1575                1580                

Asn Lys Pro Lys Asp Ile Asp Phe Gly Lys Thr Ile Lys Ala Lys Lys 
1585                1590                1595                1600

Ile Val Leu Thr Gly Thr Lys Thr Tyr Gly Asp Gly Gly Asp Lys Tyr 
                1605                1610                1615    

Gln Ser Ala Ala Glu Leu Ile Phe Thr Arg Pro Gln Val Ala Glu Thr 
            1620                1625                1630        

Pro Leu Asp Leu Ser Gly Tyr Glu Ala Ala Leu Val Lys Ala Gln Lys 
        1635                1640                1645            

Leu Thr Asp Lys Asp Asn Gln Glu Glu Val Ala Ser Val Gln Ala Ser 
    1650                1655                1660                

Met Lys Tyr Ala Thr Asp Asn His Leu Leu Thr Glu Arg Met Val Glu 
1665                1670                1675                1680

Tyr Phe Ala Asp Tyr Leu Asn Gln Leu Lys Asp Ser Ala Thr Lys Pro 
                1685                1690                1695    

Asp Ala Pro Thr Val Glu Lys Pro Glu Phe Lys Leu Arg Ser Leu Ala 
            1700                1705                1710        

Ser Glu Gln Gly Lys Thr Pro Asp Tyr Lys Gln Glu Ile Ala Arg Pro 
        1715                1720                1725            

Glu Thr Pro Glu Gln Ile Leu Pro Ala Thr Gly Glu Ser Gln Ser Asp 
    1730                1735                1740                

Thr Ala Leu Ile Leu Ala Ser Val Ser Leu Ala Leu Ser Ala Leu Phe 
1745                1750                1755                1760

Val Val Lys Thr Lys Lys Asp 
                1765        

<210>   50
<211>   719
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   50
Met Asn Lys Pro Thr Ile Leu Arg Leu Ile Lys Tyr Leu Ser Ile Ser 
1               5                   10                  15      

Phe Leu Ser Leu Val Ile Ala Ala Ile Val Leu Gly Gly Gly Val Phe 
            20                  25                  30          

Phe Tyr Tyr Val Ser Lys Ala Pro Ser Leu Ser Glu Ser Lys Leu Val 
        35                  40                  45              

Ala Thr Thr Ser Ser Lys Ile Tyr Asp Asn Lys Asn Gln Leu Ile Ala 
    50                  55                  60                  

Asp Leu Gly Ser Glu Arg Arg Val Asn Ala Gln Ala Asn Asp Ile Pro 
65                  70                  75                  80  

Thr Asp Leu Val Lys Ala Ile Val Ser Ile Glu Asp His Arg Phe Phe 
                85                  90                  95      

Asp His Arg Gly Ile Asp Thr Ile Arg Ile Leu Gly Ala Phe Leu Arg 
            100                 105                 110         

Asn Leu Gln Ser Asn Ser Leu Gln Gly Gly Ser Thr Leu Thr Gln Gln 
        115                 120                 125             

Leu Ile Lys Leu Thr Tyr Phe Ser Thr Ser Thr Ser Asp Gln Thr Ile 
    130                 135                 140                 

Ser Arg Lys Ala Gln Glu Ala Trp Leu Ala Ile Gln Leu Glu Gln Lys 
145                 150                 155                 160 

Ala Thr Lys Gln Glu Ile Leu Thr Tyr Tyr Ile Asn Lys Val Tyr Met 
                165                 170                 175     

Ser Asn Gly Asn Tyr Gly Met Gln Thr Ala Ala Gln Asn Tyr Tyr Gly 
            180                 185                 190         

Lys Asp Leu Asn Asn Leu Ser Leu Pro Gln Leu Ala Leu Leu Ala Gly 
        195                 200                 205             

Met Pro Gln Ala Pro Asn Gln Tyr Asp Pro Tyr Ser His Pro Glu Ala 
    210                 215                 220                 

Ala Gln Asp Arg Arg Asn Leu Val Leu Ser Glu Met Lys Asn Gln Gly 
225                 230                 235                 240 

Tyr Ile Ser Ala Glu Gln Tyr Glu Lys Ala Val Asn Thr Pro Ile Thr 
                245                 250                 255     

Asp Gly Leu Gln Ser Leu Lys Ser Ala Ser Asn Tyr Pro Ala Tyr Met 
            260                 265                 270         

Asp Asn Tyr Leu Lys Glu Val Ile Asn Gln Val Glu Glu Glu Thr Gly 
        275                 280                 285             

Tyr Asn Leu Leu Thr Thr Gly Met Asp Val Tyr Thr Asn Val Asp Gln 
    290                 295                 300                 

Glu Ala Gln Lys His Leu Trp Asp Ile Tyr Asn Thr Asp Glu Tyr Val 
305                 310                 315                 320 

Ala Tyr Pro Asp Asp Glu Leu Gln Val Ala Ser Thr Ile Val Asp Val 
                325                 330                 335     

Ser Asn Gly Lys Val Ile Ala Gln Leu Gly Ala Arg His Gln Ser Ser 
            340                 345                 350         

Asn Val Ser Phe Gly Ile Asn Gln Ala Val Glu Thr Asn Arg Asp Trp 
        355                 360                 365             

Gly Ser Thr Met Lys Pro Ile Thr Asp Tyr Ala Pro Ala Leu Glu Tyr 
    370                 375                 380                 

Gly Val Tyr Asp Ser Thr Ala Thr Ile Val His Asp Glu Pro Tyr Asn 
385                 390                 395                 400 

Tyr Pro Gly Thr Asn Thr Pro Val Tyr Asn Trp Asp Arg Gly Tyr Phe 
                405                 410                 415     

Gly Asn Ile Thr Leu Gln Tyr Ala Leu Gln Gln Ser Arg Asn Val Pro 
            420                 425                 430         

Ala Val Glu Thr Leu Asn Lys Val Gly Leu Asn Arg Ala Lys Thr Phe 
        435                 440                 445             

Leu Asn Gly Leu Gly Ile Asp Tyr Pro Ser Ile His Tyr Ser Asn Ala 
    450                 455                 460                 

Ile Ser Ser Asn Thr Thr Glu Ser Asp Lys Lys Tyr Gly Ala Ser Ser 
465                 470                 475                 480 

Glu Lys Met Ala Ala Ala Tyr Ala Ala Phe Ala Asn Gly Gly Thr Tyr 
                485                 490                 495     

Tyr Lys Pro Met Tyr Ile His Lys Val Val Phe Ser Asp Gly Ser Glu 
            500                 505                 510         

Lys Glu Phe Ser Asn Val Gly Thr Arg Ala Met Lys Glu Thr Thr Ala 
        515                 520                 525             

Tyr Met Met Thr Asp Met Met Lys Thr Val Leu Thr Tyr Gly Thr Gly 
    530                 535                 540                 

Arg Asn Ala Tyr Leu Ala Trp Leu Pro Gln Ala Gly Lys Thr Gly Thr 
545                 550                 555                 560 

Ser Asn Tyr Thr Asp Glu Glu Ile Glu Asn His Ile Lys Thr Ser Gln 
                565                 570                 575     

Phe Val Ala Pro Asp Glu Leu Phe Ala Gly Tyr Thr Arg Lys Tyr Ser 
            580                 585                 590         

Met Ala Val Trp Thr Gly Tyr Ser Asn Arg Leu Thr Pro Leu Val Gly 
        595                 600                 605             

Asn Gly Leu Thr Val Ala Ala Lys Val Tyr Arg Ser Met Met Thr Tyr 
    610                 615                 620                 

Leu Ser Glu Gly Ser Asn Pro Glu Asp Trp Asn Ile Pro Glu Gly Leu 
625                 630                 635                 640 

Tyr Arg Asn Gly Glu Phe Val Phe Lys Asn Gly Ala Arg Ser Thr Trp 
                645                 650                 655     

Asn Ser Pro Ala Pro Gln Gln Pro Pro Ser Thr Glu Ser Ser Ser Ser 
            660                 665                 670         

Ser Ser Asp Ser Ser Thr Ser Gln Ser Ser Ser Thr Thr Pro Ser Thr 
        675                 680                 685             

Asn Asn Ser Thr Thr Thr Asn Pro Asn Asn Asn Thr Gln Gln Ser Asn 
    690                 695                 700                 

Thr Thr Pro Asp Gln Gln Asn Gln Asn Pro Gln Pro Ala Gln Pro 
705                 710                 715                 

<210>   51
<211>   464
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   51
Met Ser Lys Lys Arg Arg Asn Arg His Lys Lys Glu Gly Gln Glu Pro 
1               5                   10                  15      

Gln Phe Asp Phe Asp Glu Ala Lys Glu Leu Thr Val Gly Gln Ala Ile 
            20                  25                  30          

Arg Lys Asn Glu Glu Val Glu Ser Gly Val Leu Pro Glu Asp Ser Ile 
        35                  40                  45              

Leu Asp Lys Tyr Val Lys Gln His Arg Asp Glu Ile Glu Ala Asp Lys 
    50                  55                  60                  

Phe Ala Thr Arg Gln Tyr Lys Lys Glu Glu Phe Val Glu Thr Gln Ser 
65                  70                  75                  80  

Leu Asp Asp Leu Ile Gln Glu Met Arg Glu Ala Val Glu Lys Ser Glu 
                85                  90                  95      

Ala Ser Ser Glu Glu Val Pro Ser Ser Glu Asp Ile Leu Leu Pro Leu 
            100                 105                 110         

Pro Leu Asp Asp Glu Glu Gln Gly Leu Asp Pro Leu Leu Leu Asp Asp 
        115                 120                 125             

Glu Asn Pro Thr Glu Met Thr Glu Glu Val Glu Glu Glu Gln Asn Leu 
    130                 135                 140                 

Ser Arg Leu Asp Gln Glu Asp Ser Glu Lys Lys Ser Lys Lys Gly Phe 
145                 150                 155                 160 

Ile Leu Thr Val Leu Ala Leu Val Ser Val Ile Ile Cys Val Ser Ala 
                165                 170                 175     

Tyr Tyr Val Tyr Arg Gln Val Ala Arg Ser Thr Lys Glu Ile Glu Thr 
            180                 185                 190         

Ser Gln Ser Thr Thr Ala Asn Gln Ser Asp Val Asp Asp Phe Asn Thr 
        195                 200                 205             

Leu Tyr Asp Ala Phe Tyr Thr Asp Ser Asn Lys Thr Ala Leu Lys Asn 
    210                 215                 220                 

Ser Gln Phe Asp Lys Leu Ser Gln Leu Lys Thr Leu Leu Asp Lys Leu 
225                 230                 235                 240 

Glu Gly Ser Arg Glu His Thr Leu Ala Lys Ser Lys Tyr Asp Ser Leu 
                245                 250                 255     

Ala Thr Gln Ile Lys Ala Ile Gln Asp Val Asn Ala Gln Phe Glu Lys 
            260                 265                 270         

Pro Ala Ile Val Asp Gly Val Leu Asp Thr Asn Ala Lys Ala Lys Ser 
        275                 280                 285             

Asp Ala Lys Phe Thr Asp Ile Lys Thr Gly Asn Thr Glu Leu Asp Lys 
    290                 295                 300                 

Val Leu Asp Lys Ala Ile Ser Leu Gly Lys Ser Gln Gln Thr Ser Thr 
305                 310                 315                 320 

Ser Ser Ser Ser Ser Ser Gln Thr Ser Ser Ser Ser Ser Ser Gln Ala 
                325                 330                 335     

Ser Ser Asn Thr Thr Ser Glu Pro Lys Pro Ser Ser Ser Asn Glu Thr 
            340                 345                 350         

Arg Ser Ser Arg Ser Glu Val Asn Met Gly Leu Ser Ser Ala Gly Val 
        355                 360                 365             

Ala Val Gln Arg Ser Ala Ser Arg Val Ala Tyr Asn Gln Ser Ala Ile 
    370                 375                 380                 

Asp Asp Ser Asn Asn Ser Ala Trp Asp Phe Ala Asp Gly Val Leu Glu 
385                 390                 395                 400 

Gln Ile Leu Ala Thr Ser Arg Ser Arg Gly Tyr Ile Thr Gly Asp Gln 
                405                 410                 415     

Tyr Ile Leu Glu Arg Val Asn Ile Val Asn Gly Asn Gly Tyr Tyr Asn 
            420                 425                 430         

Leu Tyr Lys Pro Asp Gly Thr Tyr Leu Phe Thr Leu Asn Cys Lys Thr 
        435                 440                 445             

Gly Tyr Phe Val Gly Asn Gly Ala Gly His Ala Asp Asp Leu Asp Tyr 
    450                 455                 460                 


<210>   52
<211>   340
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   52
Met Lys Leu Leu Lys Lys Met Met Gln Val Ala Leu Ala Val Phe Phe 
1               5                   10                  15      

Phe Gly Leu Leu Ala Thr Asn Thr Val Phe Ala Asn Thr Thr Gly Gly 
            20                  25                  30          

Arg Phe Val Asp Lys Asp Asn Arg Lys Tyr Tyr Val Lys Asp Asp His 
        35                  40                  45              

Lys Ala Ile Tyr Trp His Lys Ile Asp Gly Lys Thr Tyr Tyr Phe Gly 
    50                  55                  60                  

Asp Ile Gly Glu Met Val Val Gly Trp Gln Tyr Leu Glu Ile Pro Gly 
65                  70                  75                  80  

Thr Gly Tyr Arg Asp Asn Leu Phe Asp Asn Gln Pro Val Asn Glu Ile 
                85                  90                  95      

Gly Leu Gln Glu Lys Trp Tyr Tyr Phe Gly Gln Asp Gly Ala Leu Leu 
            100                 105                 110         

Glu Gln Thr Asp Lys Gln Val Leu Glu Ala Lys Thr Ser Glu Asn Thr 
        115                 120                 125             

Gly Lys Val Tyr Gly Glu Gln Tyr Pro Leu Ser Ala Glu Lys Arg Thr 
    130                 135                 140                 

Tyr Tyr Phe Asp Asn Asn Tyr Ala Val Lys Thr Gly Trp Ile Tyr Glu 
145                 150                 155                 160 

Glu Gly His Trp Tyr Tyr Leu Asn Lys Leu Gly Asn Phe Gly Asp Asp 
                165                 170                 175     

Ser Tyr Asn Pro Leu Pro Ile Gly Glu Val Ala Lys Gly Trp Thr Gln 
            180                 185                 190         

Asp Phe His Val Thr Ile Asp Ile Asp Arg Ser Lys Pro Ala Pro Trp 
        195                 200                 205             

Tyr Tyr Leu Asp Ala Ser Gly Lys Met Leu Thr Asp Trp Gln Lys Val 
    210                 215                 220                 

Asn Gly Lys Trp Tyr Tyr Phe Gly Ser Ser Gly Ser Met Ala Thr Gly 
225                 230                 235                 240 

Trp Lys Tyr Val Arg Gly Lys Trp Tyr Tyr Leu Asp Asn Lys Asn Gly 
                245                 250                 255     

Asp Met Lys Thr Gly Trp Gln Tyr Leu Gly Asn Lys Trp Tyr Tyr Leu 
            260                 265                 270         

Arg Ser Ser Gly Ala Met Val Thr Gly Trp Tyr Gln Asp Gly Ser Thr 
        275                 280                 285             

Trp Tyr Tyr Leu Asp Pro Ser Asn Gly Asp Met Lys Ile Gly Trp Thr 
    290                 295                 300                 

Lys Val Asn Gly Lys Trp Tyr Tyr Leu Asn Ser Asn Gly Ala Met Val 
305                 310                 315                 320 

Thr Gly Ser Gln Thr Ile Asp Gly Lys Val Tyr Asn Phe Ala Ser Ser 
                325                 330                 335     

Gly Glu Trp Ile 
            340 

<210>   53
<211>   332
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   53
Met Lys Ile Leu Lys Lys Thr Met Gln Val Gly Leu Thr Val Phe Phe 
1               5                   10                  15      

Phe Gly Leu Leu Gly Thr Ser Thr Val Phe Ala Asp Asp Ser Glu Gly 
            20                  25                  30          

Trp Gln Phe Val Gln Glu Asn Gly Arg Thr Tyr Tyr Lys Lys Gly Asp 
        35                  40                  45              

Leu Lys Glu Thr Tyr Trp Arg Val Ile Asp Gly Lys Tyr Tyr Tyr Phe 
    50                  55                  60                  

Asp Ser Leu Ser Gly Glu Met Val Val Gly Trp Gln Tyr Ile Pro Phe 
65                  70                  75                  80  

Pro Ser Lys Gly Ser Thr Ile Gly Pro Tyr Pro Asn Gly Ile Arg Leu 
                85                  90                  95      

Glu Gly Phe Pro Lys Ser Glu Trp Tyr Tyr Phe Asp Lys Asn Gly Val 
            100                 105                 110         

Leu Gln Glu Phe Val Gly Trp Lys Thr Leu Glu Ile Lys Thr Lys Asp 
        115                 120                 125             

Ser Val Gly Arg Lys Tyr Gly Glu Lys Arg Glu Asp Ser Glu Asp Lys 
    130                 135                 140                 

Glu Glu Lys Arg Tyr Tyr Thr Asn Tyr Tyr Phe Asn Gln Asn His Ser 
145                 150                 155                 160 

Leu Glu Thr Gly Trp Leu Tyr Asp Gln Ser Asn Trp Tyr Tyr Leu Ala 
                165                 170                 175     

Lys Thr Glu Ile Asn Gly Glu Asn Tyr Leu Gly Gly Glu Arg Arg Ala 
            180                 185                 190         

Gly Trp Ile Asn Asp Asp Ser Thr Trp Tyr Tyr Leu Asp Pro Thr Thr 
        195                 200                 205             

Gly Ile Met Gln Thr Gly Trp Gln Tyr Leu Gly Asn Lys Trp Tyr Tyr 
    210                 215                 220                 

Leu Arg Ser Ser Gly Ala Met Ala Thr Gly Trp Tyr Gln Glu Gly Thr 
225                 230                 235                 240 

Thr Trp Tyr Tyr Leu Asp His Pro Asn Gly Asp Met Lys Thr Gly Trp 
                245                 250                 255     

Gln Asn Leu Gly Asn Lys Trp Tyr Tyr Leu Arg Ser Ser Gly Ala Met 
            260                 265                 270         

Ala Thr Gly Trp Tyr Gln Asp Gly Ser Thr Trp Tyr Tyr Leu Asn Ala 
        275                 280                 285             

Gly Asn Gly Asp Met Lys Thr Gly Trp Phe Gln Val Asn Gly Asn Trp 
    290                 295                 300                 

Tyr Tyr Ala Tyr Ser Ser Gly Ala Leu Ala Val Asn Thr Thr Val Asp 
305                 310                 315                 320 

Gly Tyr Ser Val Asn Tyr Asn Gly Glu Trp Val Arg 
                325                 330         

<210>   54
<211>   285
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   54
Met Val Leu Ser Lys Tyr Tyr Gly Val Ala Asp Gly Met Asn Val Glu 
1               5                   10                  15      

Gly Arg Gly Ser Ala Asn Phe Ile Lys Asp Asn Val Leu Ile Thr Ala 
            20                  25                  30          

Ala His Asn Tyr Tyr Arg His Asp Tyr Gly Lys Glu Ala Asp Asp Ile 
        35                  40                  45              

Tyr Val Leu Pro Ala Val Ser Pro Ser Gln Glu Pro Phe Gly Lys Ile 
    50                  55                  60                  

Lys Val Lys Glu Val Arg Tyr Leu Lys Glu Phe Arg Asn Leu Asn Ser 
65                  70                  75                  80  

Lys Asp Ala Arg Glu Tyr Asp Leu Ala Leu Leu Ile Leu Glu Glu Pro 
                85                  90                  95      

Ile Gly Ala Lys Leu Gly Thr Leu Gly Leu Pro Thr Ser Gln Lys Asn 
            100                 105                 110         

Leu Thr Gly Ile Thr Val Thr Ile Thr Gly Tyr Pro Ser Tyr Asn Phe 
        115                 120                 125             

Lys Ile His Gln Met Tyr Thr Asp Lys Lys Gln Val Leu Ser Asp Asp 
    130                 135                 140                 

Gly Met Phe Leu Asp Tyr Gln Val Asp Thr Leu Glu Gly Ser Ser Gly 
145                 150                 155                 160 

Ser Thr Val Tyr Asp Ala Ser His Arg Val Val Gly Val His Thr Leu 
                165                 170                 175     

Gly Asp Gly Ala Asn Gln Ile Asn Ser Ala Val Lys Leu Asn Glu Arg 
            180                 185                 190         

Asn Leu Pro Phe Ile Tyr Ser Val Leu Lys Gly Tyr Ser Leu Glu Gly 
        195                 200                 205             

Trp Lys Lys Ile Asn Gly Ser Trp Tyr His Tyr Arg Gln His Asp Lys 
    210                 215                 220                 

Gln Thr Gly Trp Gln Glu Ile Asn Asp Thr Trp Tyr Tyr Leu Asp Ser 
225                 230                 235                 240 

Ser Gly Lys Met Leu Thr Asp Trp Gln Lys Val Asn Gly Lys Trp Tyr 
                245                 250                 255     

Tyr Leu Asn Ser Asn Gly Ala Met Val Thr Gly Ser Gln Thr Ile Asp 
            260                 265                 270         

Gly Lys Val Tyr Asn Phe Ala Ser Ser Gly Glu Trp Ile 
        275                 280                 285 

<210>   55
<211>   630
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   55
Leu Met Lys Lys Thr Phe Phe Leu Leu Val Leu Gly Leu Phe Cys Leu 
1               5                   10                  15      

Leu Pro Leu Ser Val Phe Ala Ile Asp Phe Lys Ile Asn Ser Tyr Gln 
            20                  25                  30          

Gly Asp Leu Tyr Ile His Ala Asp Asn Thr Ala Glu Phe Arg Gln Lys 
        35                  40                  45              

Ile Val Tyr Gln Phe Glu Glu Asp Phe Lys Gly Gln Ile Val Gly Leu 
    50                  55                  60                  

Gly Arg Ala Gly Lys Met Pro Ser Gly Phe Asp Ile Asp Pro His Pro 
65                  70                  75                  80  

Lys Ile Gln Ala Ala Lys Asn Gly Ala Glu Leu Ala Asp Val Thr Ser 
                85                  90                  95      

Glu Val Thr Glu Glu Ala Asp Gly Tyr Thr Val Arg Val Tyr Asn Pro 
            100                 105                 110         

Gly Gln Glu Gly Asp Ile Val Glu Val Asp Leu Val Trp Asn Leu Lys 
        115                 120                 125             

Asn Leu Leu Phe Leu Tyr Asp Asp Ile Ala Glu Leu Asn Trp Gln Pro 
    130                 135                 140                 

Leu Thr Asp Ser Ser Glu Ser Ile Glu Lys Phe Glu Phe His Val Arg 
145                 150                 155                 160 

Gly Asp Lys Gly Ala Glu Lys Leu Phe Phe His Thr Gly Lys Leu Phe 
                165                 170                 175     

Arg Glu Gly Thr Ile Glu Lys Ser Asn Leu Asp Tyr Thr Ile Arg Leu 
            180                 185                 190         

Asp Asn Leu Pro Ala Lys Arg Gly Val Glu Leu His Ala Tyr Trp Pro 
        195                 200                 205             

Arg Thr Asp Phe Ala Ser Ala Arg Asp Gln Gly Leu Lys Gly Asn Arg 
    210                 215                 220                 

Leu Glu Glu Phe Asn Lys Ile Glu Asp Ser Ile Val Arg Glu Lys Asp 
225                 230                 235                 240 

Gln Ser Lys Gln Leu Val Thr Trp Val Leu Pro Ser Ile Leu Ser Ile 
                245                 250                 255     

Ser Leu Leu Leu Ser Val Cys Phe Tyr Phe Ile Tyr Arg Arg Lys Thr 
            260                 265                 270         

Thr Pro Ser Val Lys Tyr Ala Lys Asn His Arg Leu Tyr Glu Pro Pro 
        275                 280                 285             

Met Glu Leu Glu Pro Met Val Leu Ser Glu Ala Val Tyr Ser Thr Ser 
    290                 295                 300                 

Leu Glu Glu Val Ser Pro Leu Val Lys Gly Ala Gly Lys Phe Thr Phe 
305                 310                 315                 320 

Asp Gln Leu Ile Gln Ala Thr Leu Leu Asp Val Ile Asp Arg Gly Asn 
                325                 330                 335     

Val Ser Ile Ile Ser Glu Gly Asp Ala Val Gly Leu Arg Leu Val Lys 
            340                 345                 350         

Glu Asp Gly Leu Ser Ser Phe Glu Lys Asp Cys Leu Asn Leu Ala Phe 
        355                 360                 365             

Ser Gly Lys Lys Glu Glu Thr Leu Ser Asn Leu Phe Ala Asp Tyr Lys 
    370                 375                 380                 

Val Ser Asp Ser Leu Tyr Arg Arg Ala Lys Val Ser Asp Glu Lys Arg 
385                 390                 395                 400 

Ile Gln Ala Arg Gly Leu Gln Leu Lys Ser Ser Phe Glu Glu Val Leu 
                405                 410                 415     

Asn Gln Met Gln Glu Gly Val Arg Lys Arg Val Ser Phe Trp Gly Leu 
            420                 425                 430         

Pro Asp Tyr Tyr Arg Pro Leu Thr Gly Gly Glu Lys Ala Leu Gln Val 
        435                 440                 445             

Gly Met Gly Ala Leu Thr Ile Leu Pro Leu Phe Ile Gly Phe Gly Leu 
    450                 455                 460                 

Phe Leu Tyr Ser Leu Asp Val His Gly Tyr Leu Tyr Leu Pro Leu Pro 
465                 470                 475                 480 

Ile Leu Gly Phe Leu Gly Leu Val Leu Ser Val Phe Tyr Tyr Trp Lys 
                485                 490                 495     

Leu Arg Leu Asp Asn Arg Asp Gly Val Leu Asn Glu Ala Gly Ala Glu 
            500                 505                 510         

Val Tyr Tyr Leu Trp Thr Ser Phe Glu Asn Met Leu Arg Glu Ile Ala 
        515                 520                 525             

Arg Leu Asp Gln Ala Glu Leu Glu Ser Ile Val Val Trp Asn Arg Leu 
    530                 535                 540                 

Leu Val Tyr Ala Thr Leu Phe Gly Tyr Ala Asp Lys Val Ser His Leu 
545                 550                 555                 560 

Met Lys Val His Gln Ile Gln Val Glu Asn Pro Asp Ile Asn Leu Tyr 
                565                 570                 575     

Val Ala Tyr Gly Trp His Ser Thr Phe Tyr His Ser Thr Ala Gln Met 
            580                 585                 590         

Ser His Tyr Ala Ser Val Ala Asn Thr Ala Ser Thr Tyr Ser Val Ser 
        595                 600                 605             

Ser Gly Ser Gly Ser Ser Gly Gly Gly Phe Ser Gly Gly Gly Gly Gly 
    610                 615                 620                 

Gly Ser Ile Gly Ala Phe 
625                 630 

<210>   56
<211>   665
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   56
Met Lys Ser Ile Asn Lys Phe Leu Thr Met Leu Ala Ala Leu Leu Leu 
1               5                   10                  15      

Thr Ala Ser Ser Leu Phe Ser Ala Ala Thr Val Phe Ala Ala Gly Thr 
            20                  25                  30          

Thr Thr Thr Ser Val Thr Val His Lys Leu Leu Ala Thr Asp Gly Asp 
        35                  40                  45              

Met Asp Lys Ile Ala Asn Glu Leu Glu Thr Gly Asn Tyr Ala Gly Asn 
    50                  55                  60                  

Lys Val Gly Val Leu Pro Ala Asn Ala Lys Glu Ile Ala Gly Val Met 
65                  70                  75                  80  

Phe Val Trp Thr Asn Thr Asn Asn Glu Ile Ile Asp Glu Asn Gly Gln 
                85                  90                  95      

Thr Leu Gly Val Asn Ile Asp Pro Gln Thr Phe Lys Leu Ser Gly Ala 
            100                 105                 110         

Met Pro Ala Thr Ala Met Lys Lys Leu Thr Glu Ala Glu Gly Ala Lys 
        115                 120                 125             

Phe Asn Thr Ala Asn Leu Pro Ala Ala Lys Tyr Lys Ile Tyr Glu Ile 
    130                 135                 140                 

His Ser Leu Ser Thr Tyr Val Gly Glu Asp Gly Ala Thr Leu Thr Gly 
145                 150                 155                 160 

Ser Lys Ala Val Pro Ile Glu Ile Glu Leu Pro Leu Asn Asp Val Val 
                165                 170                 175     

Asp Ala His Val Tyr Pro Lys Asn Thr Glu Ala Lys Pro Lys Ile Asp 
            180                 185                 190         

Lys Asp Phe Lys Gly Lys Ala Asn Pro Asp Thr Pro Arg Val Asp Lys 
        195                 200                 205             

Asp Thr Pro Val Asn His Gln Val Gly Asp Val Val Glu Tyr Glu Ile 
    210                 215                 220                 

Val Thr Lys Ile Pro Ala Leu Ala Asn Tyr Ala Thr Ala Asn Trp Ser 
225                 230                 235                 240 

Asp Arg Met Thr Glu Gly Leu Ala Phe Asn Lys Gly Thr Val Lys Val 
                245                 250                 255     

Thr Val Asp Asp Val Ala Leu Glu Ala Gly Asp Tyr Ala Leu Thr Glu 
            260                 265                 270         

Val Ala Thr Gly Phe Asp Leu Lys Leu Thr Asp Ala Gly Leu Ala Lys 
        275                 280                 285             

Val Asn Asp Gln Asn Ala Glu Lys Thr Val Lys Ile Thr Tyr Ser Ala 
    290                 295                 300                 

Thr Leu Asn Asp Lys Ala Ile Val Glu Val Pro Glu Ser Asn Asp Val 
305                 310                 315                 320 

Thr Phe Asn Tyr Gly Asn Asn Pro Asp His Gly Asn Thr Pro Lys Pro 
                325                 330                 335     

Asn Lys Pro Asn Glu Asn Gly Asp Leu Thr Leu Thr Lys Thr Trp Val 
            340                 345                 350         

Asp Ala Thr Gly Ala Pro Ile Pro Ala Gly Ala Glu Ala Thr Phe Asp 
        355                 360                 365             

Leu Val Asn Ala Gln Thr Gly Lys Val Val Gln Thr Val Thr Leu Thr 
    370                 375                 380                 

Thr Asp Lys Asn Thr Val Thr Val Asn Gly Leu Asp Lys Asn Thr Glu 
385                 390                 395                 400 

Tyr Lys Phe Val Glu Arg Ser Ile Lys Gly Tyr Ser Ala Asp Tyr Gln 
                405                 410                 415     

Glu Ile Thr Thr Ala Gly Glu Ile Ala Val Lys Asn Trp Lys Asp Glu 
            420                 425                 430         

Asn Pro Lys Pro Leu Asp Pro Thr Glu Pro Lys Val Val Thr Tyr Gly 
        435                 440                 445             

Lys Lys Phe Val Lys Val Asn Asp Lys Asp Asn Arg Leu Ala Gly Ala 
    450                 455                 460                 

Glu Phe Val Ile Ala Asn Ala Asp Asn Ala Gly Gln Tyr Leu Ala Arg 
465                 470                 475                 480 

Lys Ala Asp Lys Val Ser Gln Glu Glu Lys Gln Leu Val Val Thr Thr 
                485                 490                 495     

Lys Asp Ala Leu Asp Arg Ala Val Ala Ala Tyr Asn Ala Leu Thr Ala 
            500                 505                 510         

Gln Gln Gln Thr Gln Gln Glu Lys Glu Lys Val Asp Lys Ala Gln Ala 
        515                 520                 525             

Ala Tyr Asn Ala Ala Val Ile Ala Ala Asn Asn Ala Phe Glu Trp Val 
    530                 535                 540                 

Ala Asp Lys Asp Asn Glu Asn Val Val Lys Leu Val Ser Asp Ala Gln 
545                 550                 555                 560 

Gly Arg Phe Glu Ile Thr Gly Leu Leu Ala Gly Thr Tyr Tyr Leu Glu 
                565                 570                 575     

Glu Thr Lys Gln Pro Ala Gly Tyr Ala Leu Leu Thr Ser Arg Gln Lys 
            580                 585                 590         

Phe Glu Val Thr Ala Thr Ser Tyr Ser Ala Thr Gly Gln Gly Ile Glu 
        595                 600                 605             

Tyr Thr Ala Gly Ser Gly Lys Asp Asp Ala Thr Lys Val Val Asn Lys 
    610                 615                 620                 

Lys Ile Thr Ile Pro Gln Thr Gly Gly Ile Gly Thr Ile Ile Phe Ala 
625                 630                 635                 640 

Val Ala Gly Ala Ala Ile Met Gly Ile Ala Val Tyr Ala Tyr Val Lys 
                645                 650                 655     

Asn Asn Lys Asp Glu Asp Gln Leu Ala 
            660                 665 

<210>   57
<211>   279
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   57
Met Ala Val Met Ala Tyr Pro Leu Val Ser Arg Leu Tyr Tyr Arg Val 
1               5                   10                  15      

Glu Ser Asn Gln Gln Ile Ala Asp Phe Asp Lys Glu Lys Ala Thr Leu 
            20                  25                  30          

Asp Glu Ala Asp Ile Asp Glu Arg Met Lys Leu Ala Gln Ala Phe Asn 
        35                  40                  45              

Asp Ser Leu Asn Asn Val Val Ser Gly Asp Pro Trp Ser Glu Glu Met 
    50                  55                  60                  

Lys Lys Lys Gly Arg Ala Glu Tyr Ala Arg Met Leu Glu Ile His Glu 
65                  70                  75                  80  

Arg Met Gly His Val Glu Ile Pro Val Ile Asp Val Asp Leu Pro Val 
                85                  90                  95      

Tyr Ala Gly Thr Ala Glu Glu Val Leu Gln Gln Gly Ala Gly His Leu 
            100                 105                 110         

Glu Gly Thr Ser Leu Pro Ile Gly Gly Asn Ser Thr His Ala Val Ile 
        115                 120                 125             

Thr Ala His Thr Gly Leu Pro Thr Ala Lys Met Phe Thr Asp Leu Thr 
    130                 135                 140                 

Lys Leu Lys Val Gly Asp Lys Phe Tyr Val His Asn Ile Lys Glu Val 
145                 150                 155                 160 

Met Ala Tyr Gln Val Asp Gln Val Lys Val Ile Glu Pro Thr Asn Phe 
                165                 170                 175     

Asp Asp Leu Leu Ile Val Pro Gly His Asp Tyr Val Thr Leu Leu Thr 
            180                 185                 190         

Cys Thr Pro Tyr Met Ile Asn Thr His Arg Leu Leu Val Arg Gly His 
        195                 200                 205             

Arg Ile Pro Tyr Val Ala Glu Val Glu Glu Glu Phe Ile Ala Ala Asn 
    210                 215                 220                 

Lys Leu Ser His Leu Tyr Arg Tyr Leu Phe Tyr Val Ala Val Gly Leu 
225                 230                 235                 240 

Ile Val Ile Leu Leu Trp Ile Ile Arg Arg Leu Arg Lys Lys Lys Lys 
                245                 250                 255     

Gln Pro Glu Lys Ala Leu Lys Ala Leu Lys Ala Ala Arg Lys Glu Val 
            260                 265                 270         

Lys Val Glu Asp Gly Gln Gln 
        275                 

<210>   58
<211>   283
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   58
Met Ser Arg Thr Lys Leu Arg Ala Leu Leu Gly Tyr Leu Leu Met Leu 
1               5                   10                  15      

Val Ala Cys Leu Ile Pro Ile Tyr Cys Phe Gly Gln Met Val Leu Gln 
            20                  25                  30          

Ser Leu Gly Gln Val Lys Gly His Ala Thr Phe Val Lys Ser Met Thr 
        35                  40                  45              

Thr Glu Met Tyr Gln Glu Gln Gln Asn His Ser Leu Ala Tyr Asn Gln 
    50                  55                  60                  

Arg Leu Ala Ser Gln Asn Arg Ile Val Asp Pro Phe Leu Ala Glu Gly 
65                  70                  75                  80  

Tyr Glu Val Asn Tyr Gln Val Ser Asp Asp Pro Asp Ala Val Tyr Gly 
                85                  90                  95      

Tyr Leu Ser Ile Pro Ser Leu Glu Ile Met Glu Pro Val Tyr Leu Gly 
            100                 105                 110         

Ala Asp Tyr His His Leu Gly Met Gly Leu Ala His Val Asp Gly Thr 
        115                 120                 125             

Pro Leu Pro Leu Asp Gly Thr Gly Ile Arg Ser Val Ile Ala Gly His 
    130                 135                 140                 

Arg Ala Glu Pro Ser His Val Phe Phe Arg His Leu Asp Gln Leu Lys 
145                 150                 155                 160 

Val Gly Asp Ala Leu Tyr Tyr Asp Asn Gly Gln Glu Ile Val Glu Tyr 
                165                 170                 175     

Gln Met Met Asp Thr Glu Ile Ile Leu Pro Ser Glu Trp Glu Lys Leu 
            180                 185                 190         

Glu Ser Val Ser Ser Lys Asn Ile Met Thr Leu Ile Thr Cys Asp Pro 
        195                 200                 205             

Ile Pro Thr Phe Asn Lys Arg Leu Leu Val Asn Phe Glu Arg Val Ala 
    210                 215                 220                 

Val Tyr Gln Lys Ser Asp Pro Gln Thr Ala Ala Val Ala Arg Val Ala 
225                 230                 235                 240 

Phe Thr Lys Glu Gly Gln Ser Val Ser Arg Val Ala Thr Ser Gln Trp 
                245                 250                 255     

Leu Tyr Arg Gly Leu Val Val Leu Ala Phe Leu Gly Ile Leu Phe Val 
            260                 265                 270         

Leu Trp Lys Leu Ala Arg Leu Leu Arg Gly Lys 
        275                 280             

<210>   59
<211>   1659
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   59
Met Lys Asn Pro Phe Phe Glu Arg Arg Cys Arg Tyr Ser Ile Arg Lys 
1               5                   10                  15      

Leu Ser Val Gly Ala Cys Ser Leu Met Ile Gly Ala Val Leu Phe Ala 
            20                  25                  30          

Gly Pro Ala Leu Ala Glu Glu Thr Ala Val Pro Glu Asn Ser Gly Ala 
        35                  40                  45              

Asn Thr Glu Leu Val Ser Gly Glu Ser Glu His Ser Thr Asn Glu Ala 
    50                  55                  60                  

Asp Lys Gln Asn Glu Gly Glu His Ala Arg Glu Asn Lys Leu Glu Lys 
65                  70                  75                  80  

Ala Glu Gly Val Ala Ile Ala Ser Glu Thr Ala Ser Pro Ala Ser Asn 
                85                  90                  95      

Glu Ala Ala Thr Thr Glu Thr Ala Glu Ala Ala Ser Ala Ala Lys Pro 
            100                 105                 110         

Glu Glu Lys Ala Ser Glu Val Val Ala Glu Thr Pro Ser Ala Glu Ala 
        115                 120                 125             

Lys Pro Lys Ser Asp Lys Glu Thr Glu Ala Lys Pro Glu Ala Thr Asn 
    130                 135                 140                 

Gln Gly Asp Glu Ser Lys Pro Ala Ala Glu Ala Asn Lys Thr Glu Lys 
145                 150                 155                 160 

Glu Val Gln Pro Asp Val Pro Lys Asn Thr Glu Lys Thr Leu Lys Pro 
                165                 170                 175     

Lys Glu Ile Lys Phe Asn Ser Trp Glu Glu Leu Leu Lys Trp Glu Pro 
            180                 185                 190         

Gly Ala Arg Glu Asp Asp Ala Ile Asn Arg Gly Ser Val Val Leu Ala 
        195                 200                 205             

Ser Arg Arg Thr Gly His Leu Val Asn Glu Lys Ala Ser Lys Glu Ala 
    210                 215                 220                 

Lys Val Gln Ala Leu Ser Asn Thr Asn Ser Lys Ala Lys Asp His Ala 
225                 230                 235                 240 

Ser Val Gly Gly Glu Glu Phe Lys Ala Tyr Ala Phe Asp Tyr Trp Gln 
                245                 250                 255     

Tyr Leu Asp Ser Met Val Phe Trp Glu Gly Leu Val Pro Thr Pro Asp 
            260                 265                 270         

Val Ile Asp Ala Gly His Arg Asn Gly Val Pro Val Tyr Gly Thr Leu 
        275                 280                 285             

Phe Phe Asn Trp Ser Asn Ser Ile Ala Asp Gln Glu Arg Phe Ala Glu 
    290                 295                 300                 

Ala Leu Lys Gln Asp Ala Asp Gly Ser Phe Pro Ile Ala Arg Lys Leu 
305                 310                 315                 320 

Val Asp Met Ala Lys Tyr Tyr Gly Tyr Asp Gly Tyr Phe Ile Asn Gln 
                325                 330                 335     

Glu Thr Thr Gly Asp Leu Val Lys Pro Leu Gly Glu Lys Met Arg Gln 
            340                 345                 350         

Phe Met Leu Tyr Ser Lys Glu Tyr Ala Ala Lys Val Asn His Pro Ile 
        355                 360                 365             

Lys Tyr Ser Trp Tyr Asp Ala Met Thr Tyr Asn Tyr Gly Arg Tyr His 
    370                 375                 380                 

Gln Asp Gly Leu Gly Glu Tyr Asn Tyr Gln Phe Met Gln Pro Glu Gly 
385                 390                 395                 400 

Asp Lys Val Pro Ala Asp Asn Phe Phe Ala Asn Phe Asn Trp Asp Lys 
                405                 410                 415     

Ala Lys Asn Asp Tyr Thr Ile Ala Thr Ala Asn Trp Ile Gly Arg Asn 
            420                 425                 430         

Pro Tyr Asp Val Phe Ala Gly Leu Glu Leu Gln Gln Gly Gly Ser Tyr 
        435                 440                 445             

Lys Thr Lys Val Lys Trp Asn Asp Ile Leu Asp Glu Asn Gly Lys Leu 
    450                 455                 460                 

Arg Leu Ser Leu Gly Leu Phe Ala Pro Asp Thr Ile Thr Ser Leu Gly 
465                 470                 475                 480 

Lys Thr Gly Glu Asp Tyr His Lys Asn Glu Asp Ile Phe Phe Thr Gly 
                485                 490                 495     

Tyr Gln Gly Asp Pro Thr Gly Gln Lys Pro Gly Asp Lys Asp Trp Tyr 
            500                 505                 510         

Gly Ile Ala Asn Leu Val Ala Asp Arg Thr Pro Ala Val Gly Asn Thr 
        515                 520                 525             

Phe Thr Thr Ser Phe Asn Thr Gly His Gly Lys Lys Trp Phe Val Asp 
    530                 535                 540                 

Gly Lys Val Ser Lys Asp Ser Glu Trp Asn Tyr Arg Ser Val Ser Gly 
545                 550                 555                 560 

Val Leu Pro Thr Trp Arg Trp Trp Gln Thr Ser Thr Gly Glu Lys Leu 
                565                 570                 575     

Arg Ala Glu Tyr Asp Phe Thr Asp Ala Tyr Asn Gly Gly Asn Ser Leu 
            580                 585                 590         

Lys Phe Ser Gly Asp Val Ala Gly Lys Thr Asp Gln Asp Val Arg Leu 
        595                 600                 605             

Tyr Ser Thr Lys Leu Glu Val Thr Glu Lys Thr Lys Leu Arg Val Ala 
    610                 615                 620                 

His Lys Gly Gly Lys Gly Ser Lys Val Tyr Met Ala Phe Ser Thr Thr 
625                 630                 635                 640 

Pro Asp Tyr Lys Phe Asp Asp Ala Asp Ala Trp Lys Glu Leu Thr Leu 
                645                 650                 655     

Ser Asp Asn Trp Thr Asn Glu Glu Phe Asp Leu Ser Ser Leu Ala Gly 
            660                 665                 670         

Lys Thr Ile Tyr Ala Val Lys Leu Phe Phe Glu His Glu Gly Ala Val 
        675                 680                 685             

Lys Asp Tyr Gln Phe Asn Leu Gly Gln Leu Thr Ile Ser Asp Asn His 
    690                 695                 700                 

Gln Glu Pro Gln Ser Pro Thr Ser Phe Ser Val Val Lys Gln Ser Leu 
705                 710                 715                 720 

Lys Asn Ala Gln Glu Ala Glu Ala Val Val Gln Phe Lys Gly Asn Lys 
                725                 730                 735     

Asp Ala Asp Phe Tyr Glu Val Tyr Glu Lys Asp Gly Asp Ser Trp Lys 
            740                 745                 750         

Leu Leu Thr Gly Ser Ser Ser Thr Thr Ile Tyr Leu Pro Lys Val Ser 
        755                 760                 765             

Arg Ser Ala Ser Ala Gln Gly Thr Thr Gln Glu Leu Lys Val Val Ala 
    770                 775                 780                 

Val Gly Lys Asn Gly Val Arg Ser Glu Ala Ala Thr Thr Thr Phe Asp 
785                 790                 795                 800 

Trp Gly Met Thr Val Lys Asp Thr Ser Leu Pro Lys Pro Leu Ala Glu 
                805                 810                 815     

Asn Ile Val Pro Gly Ala Thr Val Ile Asp Ser Thr Phe Pro Lys Thr 
            820                 825                 830         

Glu Gly Gly Glu Gly Ile Glu Gly Met Leu Asn Gly Thr Ile Thr Ser 
        835                 840                 845             

Leu Ser Asp Lys Trp Ser Ser Ala Gln Leu Ser Gly Ser Val Asp Ile 
    850                 855                 860                 

Arg Leu Thr Lys Pro Arg Thr Val Val Arg Trp Val Met Asp His Ala 
865                 870                 875                 880 

Gly Ala Gly Gly Glu Ser Val Asn Asp Gly Leu Met Asn Thr Lys Asp 
                885                 890                 895     

Phe Asp Leu Tyr Tyr Lys Asp Ala Asp Gly Glu Trp Lys Leu Ala Lys 
            900                 905                 910         

Glu Val Arg Gly Asn Lys Ala His Val Thr Asp Ile Thr Leu Asp Lys 
        915                 920                 925             

Pro Ile Thr Ala Gln Asp Trp Arg Leu Asn Val Val Thr Ser Asp Asn 
    930                 935                 940                 

Gly Thr Pro Trp Lys Ala Ile Arg Ile Tyr Asn Trp Lys Met Tyr Glu 
945                 950                 955                 960 

Lys Leu Asp Thr Glu Ser Val Asn Ile Pro Met Ala Lys Ala Ala Ala 
                965                 970                 975     

Arg Ser Leu Gly Asn Asn Lys Val Gln Val Gly Phe Ala Asp Val Pro 
            980                 985                 990         

Ala Gly Ala Thr Ile Thr Val Tyr Asp Asn Pro Asn Ser Gln Thr Pro 
        995                 1000                1005            

Leu Ala Thr Leu Lys Ser Glu Val Gly Gly Asp Leu Ala Ser Ala Pro 
    1010                1015                1020                

Leu Asp Leu Thr Asn Gln Ser Gly Leu Leu Tyr Tyr Arg Thr Gln Leu 
1025                1030                1035                1040

Pro Gly Lys Glu Ile Ser Asn Val Leu Ala Val Ser Val Pro Lys Asp 
                1045                1050                1055    

Asp Arg Arg Ile Lys Ser Val Ser Leu Glu Thr Gly Pro Lys Lys Thr 
            1060                1065                1070        

Ser Tyr Ala Glu Gly Glu Asp Leu Asp Leu Arg Gly Gly Val Leu Arg 
        1075                1080                1085            

Val Gln Tyr Glu Gly Gly Thr Glu Asp Glu Leu Ile Arg Leu Thr His 
    1090                1095                1100                

Ala Gly Val Ser Val Ser Gly Phe Asp Thr His His Lys Gly Glu Gln 
1105                1110                1115                1120

Asn Leu Thr Leu Gln Tyr Leu Gly Gln Pro Val Asn Ala Asn Leu Ser 
                1125                1130                1135    

Val Thr Val Thr Gly Gln Asp Glu Ala Ser Pro Lys Thr Ile Leu Gly 
            1140                1145                1150        

Ile Glu Val Ser Gln Glu Pro Lys Lys Asp Tyr Leu Val Gly Asp Ser 
        1155                1160                1165            

Leu Asp Leu Ser Glu Gly Arg Phe Ala Val Ala Tyr Ser Asn Asp Thr 
    1170                1175                1180                

Met Glu Glu His Ser Phe Thr Asp Glu Gly Val Glu Ile Ser Gly Tyr 
1185                1190                1195                1200

Asp Ala Gln Lys Thr Gly Arg Gln Thr Leu Thr Leu His Tyr Gln Gly 
                1205                1210                1215    

His Glu Val Ser Phe Asp Val Leu Val Ser Pro Lys Ala Ala Leu Asn 
            1220                1225                1230        

Asp Glu Tyr Leu Lys Gln Lys Leu Ala Glu Val Glu Ala Ala Lys Asn 
        1235                1240                1245            

Lys Val Val Tyr Asn Phe Ala Ser Ser Glu Val Lys Glu Ala Phe Leu 
    1250                1255                1260                

Lys Ala Ile Glu Ala Ala Glu Gln Val Leu Lys Asp His Glu Thr Ser 
1265                1270                1275                1280

Thr Gln Asp Gln Val Asn Asp Arg Leu Asn Lys Leu Thr Glu Ala His 
                1285                1290                1295    

Lys Ala Leu Asn Gly Gln Glu Lys Phe Thr Glu Glu Lys Thr Glu Leu 
            1300                1305                1310        

Asp Arg Leu Thr Gly Glu Val Gln Glu Leu Leu Ala Ala Lys Pro Asn 
        1315                1320                1325            

His Pro Ser Gly Ser Ala Leu Ala Pro Leu Leu Glu Lys Asn Lys Ala 
    1330                1335                1340                

Leu Val Glu Lys Val Asp Leu Ser Pro Glu Glu Leu Thr Thr Ala Lys 
1345                1350                1355                1360

Gln Ser Leu Lys Asp Leu Val Ala Leu Leu Lys Glu Asp Lys Pro Ala 
                1365                1370                1375    

Val Phe Ser Asp Ser Lys Thr Gly Val Glu Val His Phe Ser Asn Lys 
            1380                1385                1390        

Glu Lys Thr Val Ile Lys Gly Leu Lys Val Glu Arg Val Gln Ala Ser 
        1395                1400                1405            

Ala Glu Glu Lys Lys Tyr Phe Ala Gly Glu Asp Ala His Val Phe Glu 
    1410                1415                1420                

Ile Glu Gly Leu Asp Glu Lys Gly Gln Asp Val Asp Leu Ser Tyr Ala 
1425                1430                1435                1440

Ser Ile Val Lys Ile Pro Ile Glu Lys Asp Lys Lys Val Lys Lys Val 
                1445                1450                1455    

Phe Phe Leu Pro Glu Gly Lys Glu Ala Val Glu Leu Ala Phe Glu Gln 
            1460                1465                1470        

Thr Asp Ser His Val Ile Phe Thr Ala Pro His Phe Thr His Tyr Ala 
        1475                1480                1485            

Phe Val Tyr Glu Ser Ala Glu Lys Pro Gln Pro Ala Lys Pro Ala Pro 
    1490                1495                1500                

Gln Asn Thr Val Leu Pro Lys Pro Thr Tyr Gln Pro Thr Ser Asp Gln 
1505                1510                1515                1520

Gln Lys Ala Pro Lys Leu Glu Val Gln Glu Glu Lys Val Ala Phe His 
                1525                1530                1535    

Arg Gln Glu His Glu Asn Thr Glu Met Leu Val Gly Glu Gln Arg Val 
            1540                1545                1550        

Ile Ile Gln Gly Arg Asp Gly Leu Leu Arg His Val Phe Glu Val Asp 
        1555                1560                1565            

Glu Asn Gly Gln Arg Arg Leu Arg Ser Thr Glu Val Ile Gln Glu Ala 
    1570                1575                1580                

Ile Pro Glu Ile Val Glu Ile Gly Thr Lys Val Lys Thr Val Pro Ala 
1585                1590                1595                1600

Val Val Ala Thr Gln Glu Lys Pro Ala Gln Asn Thr Ala Val Lys Ser 
                1605                1610                1615    

Glu Glu Ala Ser Lys Gln Leu Pro Asn Thr Gly Thr Ala Asp Ala Asn 
            1620                1625                1630        

Glu Ala Leu Ile Ala Gly Leu Ala Ser Leu Gly Leu Ala Ser Leu Ala 
        1635                1640                1645            

Leu Thr Leu Arg Arg Lys Arg Glu Asp Lys Asp 
    1650                1655                

<210>   60
<211>   487
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   60
Met Ser Ile Thr Ser Phe Val Lys Arg Ile Gln Asp Ile Thr Arg Asn 
1               5                   10                  15      

Asp Ala Gly Val Asn Gly Asp Ala Gln Arg Ile Glu Gln Met Ser Trp 
            20                  25                  30          

Leu Leu Phe Leu Lys Ile Tyr Asp Ser Arg Glu Met Val Trp Glu Leu 
        35                  40                  45              

Glu Glu Asp Glu Tyr Glu Ser Ile Ile Pro Glu Glu Leu Lys Trp Arg 
    50                  55                  60                  

Asn Trp Ala His Ala Gln Asn Gly Glu Arg Val Leu Thr Gly Asp Glu 
65                  70                  75                  80  

Leu Leu Asp Phe Val Asn Asn Lys Leu Phe Lys Glu Leu Lys Glu Leu 
                85                  90                  95      

Glu Ile Thr Ser Asn Met Pro Ile Arg Lys Thr Ile Val Lys Ser Ala 
            100                 105                 110         

Phe Glu Asp Ala Asn Asn Tyr Met Lys Asn Gly Val Leu Leu Arg Gln 
        115                 120                 125             

Val Ile Asn Val Ile Asp Glu Val Asp Phe Asn Ser Pro Glu Asp Arg 
    130                 135                 140                 

His Ser Phe Asn Asp Ile Tyr Glu Lys Ile Leu Lys Asp Ile Gln Asn 
145                 150                 155                 160 

Ala Gly Asn Ser Gly Glu Phe Tyr Thr Pro Arg Ala Ala Thr Asp Phe 
                165                 170                 175     

Ile Ala Glu Val Leu Asp Pro Lys Leu Gly Glu Ser Met Ala Asp Leu 
            180                 185                 190         

Ala Cys Gly Thr Gly Gly Phe Leu Thr Ser Thr Leu Asn Arg Leu Ser 
        195                 200                 205             

Ser Gln Arg Lys Thr Ser Glu Asp Thr Lys Lys Tyr Asn Thr Ala Val 
    210                 215                 220                 

Phe Gly Ile Glu Lys Lys Ala Phe Pro His Leu Leu Ala Val Thr Asn 
225                 230                 235                 240 

Leu Phe Leu His Glu Ile Asp Asp Pro Lys Ile Val His Gly Asn Thr 
                245                 250                 255     

Leu Glu Lys Asn Val Arg Glu Tyr Thr Asp Asp Glu Lys Phe Asp Ile 
            260                 265                 270         

Ile Met Met Asn Pro Pro Phe Gly Gly Ser Glu Leu Glu Thr Ile Lys 
        275                 280                 285             

Asn Asn Phe Pro Ala Glu Leu Arg Ser Ser Glu Thr Ala Asp Leu Phe 
    290                 295                 300                 

Met Ala Val Ile Met Tyr Arg Leu Lys Glu Asn Gly Arg Val Gly Val 
305                 310                 315                 320 

Ile Leu Pro Asp Gly Phe Leu Phe Gly Glu Gly Val Lys Thr Arg Leu 
                325                 330                 335     

Lys Gln Lys Leu Val Asp Glu Phe Asn Leu His Thr Ile Ile Arg Leu 
            340                 345                 350         

Pro His Ser Val Phe Ala Pro Tyr Thr Gly Ile His Thr Asn Ile Leu 
        355                 360                 365             

Phe Phe Asp Lys Thr Lys Lys Thr Glu Glu Thr Trp Phe Tyr Arg Leu 
    370                 375                 380                 

Asp Met Pro Asp Gly Tyr Lys Asn Phe Ser Lys Thr Lys Pro Met Lys 
385                 390                 395                 400 

Ser Glu His Phe Asn Pro Val Arg Asp Trp Trp Glu Asn Arg Glu Glu 
                405                 410                 415     

Ile Leu Glu Gly Lys Phe Tyr Lys Ser Lys Ser Phe Thr Pro Ser Glu 
            420                 425                 430         

Leu Ala Glu Leu Asn Tyr Asn Leu Asp Gln Cys Asp Phe Pro Lys Glu 
        435                 440                 445             

Glu Glu Glu Ile Leu Asn Pro Phe Glu Leu Ile Gln Asn Tyr Gln Ala 
    450                 455                 460                 

Glu Arg Ala Thr Leu Asn His Lys Ile Asp Asn Val Leu Ala Asp Ile 
465                 470                 475                 480 

Leu Gln Leu Leu Glu Asp Lys 
                485         

<210>   61
<211>   378
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   61
Met Asn Asn Thr Glu Phe Tyr Asp Arg Leu Gly Val Ser Lys Asn Ala 
1               5                   10                  15      

Ser Ala Asp Glu Ile Lys Lys Ala Tyr Arg Lys Leu Ser Lys Lys Tyr 
            20                  25                  30          

His Pro Asp Ile Asn Lys Glu Pro Gly Ala Glu Asp Lys Tyr Lys Glu 
        35                  40                  45              

Val Gln Glu Ala Tyr Glu Thr Leu Ser Asp Asp Gln Lys Arg Ala Ala 
    50                  55                  60                  

Tyr Asp Gln Tyr Gly Ala Ala Gly Ala Asn Gly Gly Phe Gly Gly Ala 
65                  70                  75                  80  

Gly Gly Phe Gly Gly Phe Asn Gly Ala Gly Gly Phe Gly Gly Phe Glu 
                85                  90                  95      

Asp Ile Phe Ser Ser Phe Phe Gly Gly Gly Gly Ser Ser Arg Asn Pro 
            100                 105                 110         

Asn Ala Pro Arg Gln Gly Asp Asp Leu Gln Tyr Arg Val Asn Leu Thr 
        115                 120                 125             

Phe Glu Glu Ala Ile Phe Gly Thr Glu Lys Glu Val Lys Tyr His Arg 
    130                 135                 140                 

Glu Ala Gly Cys Arg Thr Cys Asn Gly Ser Gly Ala Lys Pro Gly Thr 
145                 150                 155                 160 

Ser Pro Val Thr Cys Gly Arg Cys His Gly Ala Gly Val Ile Asn Val 
                165                 170                 175     

Asp Thr Gln Thr Pro Leu Gly Met Met Arg Arg Gln Val Thr Cys Asp 
            180                 185                 190         

Val Cys His Gly Arg Gly Lys Glu Ile Lys Tyr Pro Cys Thr Thr Cys 
        195                 200                 205             

His Gly Thr Gly His Glu Lys Gln Ala His Ser Val His Val Lys Ile 
    210                 215                 220                 

Pro Ala Gly Val Glu Thr Gly Gln Gln Ile Arg Leu Ala Gly Gln Gly 
225                 230                 235                 240 

Glu Ala Gly Phe Asn Gly Gly Pro Tyr Gly Asp Leu Tyr Val Val Val 
                245                 250                 255     

Ser Val Glu Ala Ser Asp Lys Phe Glu Arg Glu Gly Thr Thr Ile Phe 
            260                 265                 270         

Tyr Asn Leu Asn Leu Asn Phe Val Gln Ala Ala Leu Gly Asp Thr Val 
        275                 280                 285             

Asp Ile Pro Thr Val His Gly Asp Val Glu Leu Val Ile Pro Glu Gly 
    290                 295                 300                 

Thr Gln Thr Gly Lys Lys Phe Arg Leu Arg Ser Lys Gly Ala Pro Ser 
305                 310                 315                 320 

Leu Arg Gly Gly Ala Val Gly Asp Gln Tyr Val Thr Val Asn Val Val 
                325                 330                 335     

Thr Pro Thr Gly Leu Asn Asp Arg Gln Lys Val Ala Leu Lys Glu Phe 
            340                 345                 350         

Ala Ala Ala Gly Asp Leu Lys Val Asn Pro Lys Lys Lys Gly Phe Phe 
        355                 360                 365             

Asp His Ile Lys Asp Ala Phe Asp Gly Glu 
    370                 375             

<210>   62
<211>   453
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   62
Met Asn Pro Asn Leu Phe Arg Ser Val Glu Phe Tyr Gln Arg Arg Tyr 
1               5                   10                  15      

His Asn Tyr Ala Thr Val Leu Ile Ile Pro Leu Ser Leu Leu Phe Thr 
            20                  25                  30          

Phe Ile Leu Ile Phe Ser Leu Val Ala Thr Lys Glu Ile Thr Val Thr 
        35                  40                  45              

Ser Gln Gly Glu Ile Ala Pro Thr Ser Val Ile Ala Ser Ile Gln Ser 
    50                  55                  60                  

Thr Ser Asp Asn Pro Ile Leu Ala Asn His Leu Val Ala Asn Gln Val 
65                  70                  75                  80  

Val Glu Lys Gly Asp Leu Leu Ile Lys Tyr Ser Glu Thr Met Glu Glu 
                85                  90                  95      

Ser Gln Lys Thr Ala Leu Ala Thr Gln Leu Gln Arg Leu Glu Lys Gln 
            100                 105                 110         

Lys Glu Gly Leu Gly Ile Leu Lys Gln Ser Leu Glu Lys Ala Thr Asp 
        115                 120                 125             

Leu Phe Ser Gly Glu Asp Glu Phe Gly Tyr His Asn Thr Phe Met Asn 
    130                 135                 140                 

Phe Thr Lys Gln Ser His Asp Ile Glu Leu Gly Ile Thr Lys Thr Asn 
145                 150                 155                 160 

Thr Glu Val Ser Asn Gln Ala Asn Leu Ser Asn Ser Ser Ser Ser Ala 
                165                 170                 175     

Ile Glu Gln Glu Ile Thr Lys Val Gln Gln Gln Ile Gly Glu Tyr Gln 
            180                 185                 190         

Glu Leu Arg Asp Ala Ile Ile Asn Asn Arg Ala Arg Leu Pro Thr Gly 
        195                 200                 205             

Asn Pro His Gln Ser Ile Leu Asn Arg Tyr Leu Val Ala Ser Gln Gly 
    210                 215                 220                 

Gln Thr Gln Gly Thr Ala Glu Glu Pro Phe Leu Ser Gln Ile Asn Gln 
225                 230                 235                 240 

Ser Ile Ala Gly Leu Glu Ser Ser Ile Ala Ser Leu Lys Ile Gln Gln 
                245                 250                 255     

Ala Gly Ile Gly Ser Val Ala Thr Tyr Asp Asn Ser Leu Ala Thr Lys 
            260                 265                 270         

Ile Glu Val Leu Arg Thr Gln Phe Leu Gln Thr Ala Ser Gln Gln Gln 
        275                 280                 285             

Leu Thr Val Glu Asn Gln Leu Thr Glu Leu Lys Val Gln Leu Asp Gln 
    290                 295                 300                 

Ala Thr Gln Arg Leu Glu Asn Asn Thr Leu Thr Ser Pro Ser Lys Gly 
305                 310                 315                 320 

Ile Val His Leu Asn Ser Glu Phe Glu Gly Lys Asn Arg Ile Pro Thr 
                325                 330                 335     

Gly Thr Glu Ile Ala Gln Ile Phe Pro Val Ile Thr Asp Thr Arg Glu 
            340                 345                 350         

Val Leu Ile Thr Tyr Tyr Val Ser Ser Asp Tyr Leu Pro Leu Leu Asp 
        355                 360                 365             

Lys Gly Gln Thr Val Arg Leu Lys Leu Glu Lys Ile Gly Asn His Gly 
    370                 375                 380                 

Thr Thr Ile Ile Gly Gln Leu Gln Thr Ile Asp Gln Thr Pro Thr Arg 
385                 390                 395                 400 

Thr Glu Gln Gly Asn Leu Phe Lys Leu Thr Ala Leu Ala Lys Leu Ser 
                405                 410                 415     

Asn Glu Asp Ser Lys Leu Ile Gln Tyr Gly Leu Gln Gly Arg Val Thr 
            420                 425                 430         

Ser Val Thr Thr Lys Lys Thr Tyr Phe Asp Tyr Phe Lys Asp Lys Ile 
        435                 440                 445             

Leu Thr His Ser Asp 
    450             

<210>   63
<211>   131
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   63
Met Ser Lys Lys Leu Asn Arg Lys Lys Gln Leu Arg Asn Gly Leu Arg 
1               5                   10                  15      

Arg Ala Gly Ala Phe Ser Ser Thr Val Thr Lys Val Val Asp Glu Thr 
            20                  25                  30          

Lys Lys Val Val Lys Arg Ala Glu Gln Ser Ala Ser Ala Ala Gly Lys 
        35                  40                  45              

Ala Val Ser Lys Lys Val Glu Gln Ala Val Glu Ala Thr Lys Glu Gln 
    50                  55                  60                  

Ala Gln Lys Val Ala Asn Ser Val Glu Asp Phe Ala Ala Asn Leu Gly 
65                  70                  75                  80  

Gly Leu Pro Leu Asp Arg Ala Lys Thr Phe Tyr Asp Glu Gly Ile Lys 
                85                  90                  95      

Ser Ala Ser Asp Phe Lys Asn Trp Thr Glu Lys Glu Leu Leu Ala Leu 
            100                 105                 110         

Lys Gly Ile Gly Pro Ala Thr Ile Lys Lys Leu Lys Glu Asn Gly Ile 
        115                 120                 125             

Lys Phe Lys 
    130     

<210>   64
<211>   254
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   64
Leu Ile Ser Leu Phe Gly Leu Ala Ala Ala Lys Pro Val Gln Ala Asp 
1               5                   10                  15      

Thr Ser Ile Ala Asp Ile Gln Lys Arg Gly Glu Leu Val Val Gly Val 
            20                  25                  30          

Lys Gln Asp Val Pro Asn Phe Gly Tyr Lys Asp Pro Lys Thr Gly Thr 
        35                  40                  45              

Tyr Ser Gly Ile Glu Thr Asp Leu Ala Lys Met Val Ala Asp Glu Leu 
    50                  55                  60                  

Lys Val Lys Ile Arg Tyr Val Pro Val Thr Ala Gln Thr Arg Gly Pro 
65                  70                  75                  80  

Leu Leu Asp Asn Glu Gln Val Asp Met Asp Ile Ala Thr Phe Thr Ile 
                85                  90                  95      

Thr Asp Glu Arg Lys Lys Leu Tyr Asn Phe Thr Ser Pro Tyr Tyr Thr 
            100                 105                 110         

Asp Ala Ser Gly Phe Leu Val Asn Lys Ser Ala Lys Ile Lys Lys Ile 
        115                 120                 125             

Glu Asp Leu Asn Gly Lys Thr Ile Gly Val Ala Gln Gly Ser Ile Thr 
    130                 135                 140                 

Gln Arg Leu Ile Thr Glu Leu Gly Lys Lys Lys Gly Leu Lys Phe Lys 
145                 150                 155                 160 

Phe Val Glu Leu Gly Ser Tyr Pro Glu Leu Ile Thr Ser Leu His Ala 
                165                 170                 175     

His Arg Ile Asp Thr Phe Ser Val Asp Arg Ser Ile Leu Ser Gly Tyr 
            180                 185                 190         

Thr Ser Lys Arg Thr Ala Leu Leu Asp Asp Ser Phe Lys Pro Ser Asp 
        195                 200                 205             

Tyr Gly Ile Val Thr Lys Lys Ser Asn Thr Glu Leu Asn Asp Tyr Leu 
    210                 215                 220                 

Asp Asn Leu Val Thr Lys Trp Ser Lys Asp Gly Ser Leu Gln Lys Leu 
225                 230                 235                 240 

Tyr Asp Arg Tyr Lys Leu Lys Pro Ser Ser His Thr Ala Asp 
                245                 250                 

<210>   65
<211>   553
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   65
Met Ser Asn Ile Ser Leu Thr Thr Leu Gly Gly Val Arg Glu Asn Gly 
1               5                   10                  15      

Lys Asn Met Tyr Ile Ala Glu Ile Gly Glu Ser Ile Phe Val Leu Asn 
            20                  25                  30          

Val Gly Leu Lys Tyr Pro Glu Asn Glu Gln Leu Gly Val Asp Val Val 
        35                  40                  45              

Ile Pro Asn Met Asp Tyr Leu Phe Glu Asn Ser Asp Arg Ile Ala Gly 
    50                  55                  60                  

Val Phe Leu Thr His Gly His Ala Asp Ala Ile Gly Ala Leu Pro Tyr 
65                  70                  75                  80  

Leu Leu Ala Glu Ala Lys Val Pro Val Phe Gly Ser Glu Leu Thr Ile 
                85                  90                  95      

Glu Leu Ala Lys Leu Phe Val Lys Gly Asn Asp Ala Val Lys Lys Phe 
            100                 105                 110         

Asn Asp Phe His Val Ile Asp Glu Asn Thr Glu Ile Asp Phe Gly Gly 
        115                 120                 125             

Thr Val Val Ser Phe Phe Pro Thr Thr Tyr Ser Val Pro Glu Ser Leu 
    130                 135                 140                 

Gly Ile Val Leu Lys Thr Ser Glu Gly Ser Ile Val Tyr Thr Gly Asp 
145                 150                 155                 160 

Phe Lys Phe Asp Gln Thr Ala Ser Glu Ser Tyr Ala Thr Asp Phe Ala 
                165                 170                 175     

Arg Leu Ala Glu Ile Gly Arg Asp Gly Val Leu Ala Leu Leu Ser Asp 
            180                 185                 190         

Ser Ala Asn Ala Asp Ser Asn Ile Gln Val Ala Ser Glu Ser Glu Val 
        195                 200                 205             

Arg Asp Glu Ile Thr Gln Thr Ile Ala Asp Trp Glu Gly Arg Ile Ile 
    210                 215                 220                 

Val Ala Ala Val Ser Ser Asn Leu Ser Arg Ile Gln Gln Ile Phe Asp 
225                 230                 235                 240 

Ala Ala Asp Lys Thr Gly Arg Arg Ile Val Leu Thr Gly Phe Asp Ile 
                245                 250                 255     

Glu Asn Ile Val Arg Thr Ala Ile Arg Leu Lys Lys Leu Ser Leu Ala 
            260                 265                 270         

Asn Glu Ile Leu Leu Ile Lys Pro Lys Asp Met Ser Arg Phe Glu Asp 
        275                 280                 285             

His Glu Leu Ile Ile Leu Glu Thr Gly Arg Met Gly Glu Pro Ile Asn 
    290                 295                 300                 

Gly Leu Arg Lys Met Ser Ile Gly Arg His Arg Tyr Val Glu Ile Lys 
305                 310                 315                 320 

Asp Gly Asp Leu Val Tyr Ile Ala Thr Ala Pro Ser Ile Ala Lys Glu 
                325                 330                 335     

Ala Phe Val Ala Arg Val Glu Asn Met Ile Tyr Gln Ala Gly Gly Val 
            340                 345                 350         

Val Lys Leu Ile Thr Gln Ser Leu His Val Ser Gly His Gly Asn Val 
        355                 360                 365             

Arg Asp Leu Gln Leu Met Ile Asn Leu Leu Gln Pro Lys Tyr Leu Phe 
    370                 375                 380                 

Pro Val Gln Gly Glu Tyr Arg Glu Leu Asp Ala His Ala Lys Ala Ala 
385                 390                 395                 400 

Met Ala Val Gly Met Leu Pro Glu Arg Ile Phe Ile Pro Lys Lys Gly 
                405                 410                 415     

Thr Thr Met Ala Tyr Glu Asn Gly Asp Phe Val Pro Ala Gly Ser Val 
            420                 425                 430         

Ser Ala Gly Asp Ile Leu Ile Asp Gly Asn Ala Ile Gly Asp Val Gly 
        435                 440                 445             

Asn Val Val Leu Arg Asp Arg Lys Val Leu Ser Glu Asp Gly Ile Phe 
    450                 455                 460                 

Ile Val Ala Ile Thr Val Asn Arg Arg Glu Lys Lys Ile Val Ala Arg 
465                 470                 475                 480 

Ala Arg Val His Thr Arg Gly Phe Val Tyr Leu Lys Lys Ser Arg Asp 
                485                 490                 495     

Ile Leu Arg Glu Ser Ser Glu Leu Ile Asn Gln Thr Val Glu Glu Tyr 
            500                 505                 510         

Leu Gln Gly Asp Asp Phe Asp Trp Ala Asp Leu Lys Gly Lys Val Arg 
        515                 520                 525             

Asp Asn Leu Thr Lys Tyr Leu Phe Asp Gln Thr Lys Arg Arg Pro Ala 
    530                 535                 540                 

Ile Leu Pro Val Val Met Glu Ala Lys 
545                 550             

<210>   66
<211>   2233
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   66
Met Gly Lys Gly His Trp Asn Arg Lys Arg Val Tyr Ser Ile Arg Lys 
1               5                   10                  15      

Phe Ala Val Gly Ala Cys Ser Val Met Ile Gly Thr Cys Ala Val Leu 
            20                  25                  30          

Leu Gly Gly Asn Ile Ala Gly Glu Ser Val Val Tyr Ala Asp Glu Thr 
        35                  40                  45              

Leu Ile Thr His Thr Ala Glu Lys Pro Lys Glu Glu Lys Met Ile Val 
    50                  55                  60                  

Glu Glu Lys Ala Asp Lys Ala Leu Glu Thr Lys Asn Ile Val Glu Arg 
65                  70                  75                  80  

Thr Glu Gln Ser Glu Pro Ser Ser Thr Glu Ala Ile Ala Ser Glu Lys 
                85                  90                  95      

Lys Glu Asp Glu Ala Val Thr Pro Lys Glu Glu Lys Val Ser Ala Lys 
            100                 105                 110         

Pro Glu Glu Lys Ala Pro Arg Ile Glu Ser Gln Ala Ser Asn Gln Glu 
        115                 120                 125             

Lys Pro Leu Lys Glu Asp Ala Lys Ala Val Thr Asn Glu Glu Val Asn 
    130                 135                 140                 

Gln Met Ile Glu Asp Arg Lys Val Asp Phe Asn Gln Asn Trp Tyr Phe 
145                 150                 155                 160 

Lys Leu Asn Ala Asn Ser Lys Glu Ala Ile Lys Pro Asp Ala Asp Val 
                165                 170                 175     

Ser Thr Trp Lys Lys Leu Asp Leu Pro Tyr Asp Trp Ser Ile Phe Asn 
            180                 185                 190         

Asp Phe Asp His Glu Ser Pro Ala Gln Asn Glu Gly Gly Gln Leu Asn 
        195                 200                 205             

Gly Gly Glu Ala Trp Tyr Arg Lys Thr Phe Lys Leu Asp Glu Lys Asp 
    210                 215                 220                 

Leu Lys Lys Asn Val Arg Leu Thr Phe Asp Gly Val Tyr Met Asp Ser 
225                 230                 235                 240 

Gln Val Tyr Val Asn Gly Gln Leu Val Gly His Tyr Pro Asn Gly Tyr 
                245                 250                 255     

Asn Gln Phe Ser Tyr Asp Ile Thr Lys Tyr Leu Gln Lys Asp Gly Arg 
            260                 265                 270         

Glu Asn Val Ile Ala Val His Ala Val Asn Lys Gln Pro Ser Ser Arg 
        275                 280                 285             

Trp Tyr Ser Gly Ser Gly Ile Tyr Arg Asp Val Thr Leu Gln Val Thr 
    290                 295                 300                 

Asp Lys Val His Val Glu Lys Asn Gly Thr Thr Ile Leu Thr Pro Lys 
305                 310                 315                 320 

Leu Glu Glu Gln Gln His Gly Lys Val Glu Thr His Val Thr Ser Lys 
                325                 330                 335     

Ile Val Asn Thr Asp Asp Lys Asp His Glu Leu Val Ala Glu Tyr Gln 
            340                 345                 350         

Ile Val Glu Arg Gly Gly His Ala Val Thr Gly Leu Val Arg Thr Ala 
        355                 360                 365             

Ser Arg Thr Leu Lys Ala His Glu Ser Thr Ser Leu Asp Ala Ile Leu 
    370                 375                 380                 

Glu Val Glu Arg Pro Lys Leu Trp Thr Val Leu Asn Asp Lys Pro Ala 
385                 390                 395                 400 

Leu Tyr Glu Leu Ile Thr Arg Val Tyr Arg Asp Gly Gln Leu Val Asp 
                405                 410                 415     

Ala Lys Lys Asp Leu Phe Gly Tyr Arg Tyr Tyr His Trp Thr Pro Asn 
            420                 425                 430         

Glu Gly Phe Ser Leu Asn Gly Glu Arg Ile Lys Phe His Gly Val Ser 
        435                 440                 445             

Leu His His Asp His Gly Ala Leu Gly Ala Glu Glu Asn Tyr Lys Ala 
    450                 455                 460                 

Glu Tyr Arg Arg Leu Lys Gln Met Lys Glu Met Gly Val Asn Ser Ile 
465                 470                 475                 480 

Arg Thr Thr His Asn Pro Ala Ser Glu Gln Thr Leu Gln Ile Ala Ala 
                485                 490                 495     

Glu Leu Gly Leu Leu Val Gln Glu Glu Ala Phe Asp Thr Trp Tyr Gly 
            500                 505                 510         

Gly Lys Lys Pro Tyr Asp Tyr Gly Arg Phe Phe Glu Lys Asp Ala Thr 
        515                 520                 525             

His Pro Glu Ala Arg Lys Gly Glu Lys Trp Ser Asp Phe Asp Leu Arg 
    530                 535                 540                 

Thr Met Val Glu Arg Gly Lys Asn Asn Pro Ala Ile Phe Met Trp Ser 
545                 550                 555                 560 

Ile Gly Asn Glu Ile Gly Glu Ala Asn Gly Asp Ala His Ser Leu Ala 
                565                 570                 575     

Thr Val Lys Arg Leu Val Lys Val Ile Lys Asp Val Asp Lys Thr Arg 
            580                 585                 590         

Tyr Val Thr Met Gly Ala Asp Lys Phe Arg Phe Gly Asn Gly Ser Gly 
        595                 600                 605             

Gly His Glu Lys Ile Ala Asp Glu Leu Asp Ala Val Gly Phe Asn Tyr 
    610                 615                 620                 

Ser Glu Asp Asn Tyr Lys Ala Leu Arg Ala Lys His Pro Lys Trp Leu 
625                 630                 635                 640 

Ile Tyr Gly Ser Glu Thr Ser Ser Ala Thr Arg Thr Arg Gly Ser Tyr 
                645                 650                 655     

Tyr Arg Pro Glu Arg Glu Leu Lys His Ser Asn Gly Pro Glu Arg Asn 
            660                 665                 670         

Tyr Glu Gln Ser Asp Tyr Gly Asn Asp Arg Val Gly Trp Gly Lys Thr 
        675                 680                 685             

Ala Thr Ala Ser Trp Thr Phe Asp Arg Asp Asn Ala Gly Tyr Ala Gly 
    690                 695                 700                 

Gln Phe Ile Trp Thr Gly Thr Asp Tyr Ile Gly Glu Pro Thr Pro Trp 
705                 710                 715                 720 

His Asn Gln Asn Gln Thr Pro Val Lys Ser Ser Tyr Phe Gly Ile Val 
                725                 730                 735     

Asp Thr Ala Gly Ile Pro Lys His Asp Phe Tyr Leu Tyr Gln Ser Gln 
            740                 745                 750         

Trp Val Ser Val Lys Lys Lys Pro Met Val His Leu Leu Pro His Trp 
        755                 760                 765             

Asn Trp Glu Asn Lys Glu Leu Ala Ser Lys Val Ala Asp Ser Glu Gly 
    770                 775                 780                 

Lys Ile Pro Val Arg Ala Tyr Ser Asn Ala Ser Ser Val Glu Leu Phe 
785                 790                 795                 800 

Leu Asn Gly Lys Ser Leu Gly Leu Lys Thr Phe Asn Lys Lys Gln Thr 
                805                 810                 815     

Ser Asp Gly Arg Thr Tyr Gln Glu Gly Ala Asn Ala Asn Glu Leu Tyr 
            820                 825                 830         

Leu Glu Trp Lys Val Ala Tyr Gln Pro Gly Thr Leu Glu Ala Ile Ala 
        835                 840                 845             

Arg Asp Glu Ser Gly Lys Glu Ile Ala Arg Asp Lys Ile Thr Thr Ala 
    850                 855                 860                 

Gly Lys Pro Ala Ala Val Arg Leu Ile Lys Glu Asp His Ala Ile Ala 
865                 870                 875                 880 

Ala Asp Gly Lys Asp Leu Thr Tyr Ile Tyr Tyr Glu Ile Val Asp Ser 
                885                 890                 895     

Gln Gly Asn Val Val Pro Thr Ala Asn Asn Leu Val Arg Phe Gln Leu 
            900                 905                 910         

His Gly Gln Gly Gln Leu Val Gly Val Asp Asn Gly Glu Gln Ala Ser 
        915                 920                 925             

Arg Glu Arg Tyr Lys Ala Gln Ala Asp Gly Ser Trp Ile Arg Lys Ala 
    930                 935                 940                 

Phe Asn Gly Lys Gly Val Ala Ile Val Lys Ser Thr Glu Gln Ala Gly 
945                 950                 955                 960 

Lys Phe Thr Leu Thr Ala His Ser Asp Leu Leu Lys Ser Asn Gln Val 
                965                 970                 975     

Thr Val Phe Thr Gly Lys Lys Glu Gly Gln Glu Lys Thr Val Leu Gly 
            980                 985                 990         

Thr Glu Val Pro Lys Val Gln Thr Ile Ile Gly Glu Ala Pro Glu Met 
        995                 1000                1005            

Pro Thr Thr Val Pro Phe Val Tyr Ser Asp Gly Ser Arg Ala Glu Arg 
    1010                1015                1020                

Pro Val Thr Trp Ser Ser Val Asp Val Ser Lys Pro Gly Ile Val Thr 
1025                1030                1035                1040

Val Lys Gly Met Ala Asp Gly Arg Glu Val Glu Ala Arg Val Glu Val 
                1045                1050                1055    

Ile Ala Leu Lys Ser Glu Leu Pro Val Val Lys Arg Ile Ala Pro Asn 
            1060                1065                1070        

Thr Asp Leu Asn Ser Val Asp Lys Ser Val Ser Tyr Val Leu Ile Asp 
        1075                1080                1085            

Gly Ser Val Glu Glu Tyr Glu Val Asp Lys Trp Glu Ile Ala Glu Glu 
    1090                1095                1100                

Asp Lys Ala Lys Leu Ala Ile Pro Gly Ser Arg Ile Gln Ala Thr Gly 
1105                1110                1115                1120

Tyr Leu Glu Gly Gln Pro Ile His Ala Thr Leu Val Val Glu Glu Gly 
                1125                1130                1135    

Asn Pro Ala Ala Pro Ala Val Pro Thr Val Thr Val Gly Gly Glu Ala 
            1140                1145                1150        

Val Thr Gly Leu Thr Ser Gln Lys Pro Met Gln Tyr Arg Thr Leu Ala 
        1155                1160                1165            

Tyr Gly Ala Lys Leu Pro Glu Val Thr Ala Ser Ala Lys Asn Ala Ala 
    1170                1175                1180                

Val Thr Val Leu Gln Ala Ser Ala Ala Asn Gly Met Arg Ala Ser Ile 
1185                1190                1195                1200

Phe Ile Gln Pro Lys Asp Gly Gly Pro Leu Gln Thr Tyr Ala Ile Gln 
                1205                1210                1215    

Phe Leu Glu Glu Ala Pro Lys Ile Ala His Leu Ser Leu Gln Val Glu 
            1220                1225                1230        

Lys Ala Asp Ser Leu Lys Glu Asp Gln Thr Val Lys Leu Ser Val Arg 
        1235                1240                1245            

Ala His Tyr Gln Asp Gly Thr Gln Ala Val Leu Pro Ala Asp Lys Val 
    1250                1255                1260                

Thr Phe Ser Thr Ser Gly Glu Gly Glu Val Ala Ile Arg Lys Gly Met 
1265                1270                1275                1280

Leu Glu Leu His Lys Pro Gly Ala Val Thr Leu Asn Ala Glu Tyr Glu 
                1285                1290                1295    

Gly Ala Lys Asp Gln Val Glu Leu Thr Ile Gln Ala Asn Thr Glu Lys 
            1300                1305                1310        

Lys Ile Ala Gln Ser Ile Arg Pro Val Asn Val Val Thr Asp Leu His 
        1315                1320                1325            

Gln Glu Pro Ser Leu Pro Ala Thr Val Thr Val Glu Tyr Asp Lys Gly 
    1330                1335                1340                

Phe Pro Lys Thr His Lys Val Thr Trp Gln Ala Ile Pro Lys Glu Lys 
1345                1350                1355                1360

Leu Asp Ser Tyr Gln Thr Phe Glu Val Leu Gly Lys Val Glu Gly Ile 
                1365                1370                1375    

Asp Leu Glu Ala Arg Ala Lys Val Ser Val Glu Gly Ile Val Ser Val 
            1380                1385                1390        

Glu Glu Val Ser Val Thr Thr Pro Ile Ala Glu Ala Pro Gln Leu Pro 
        1395                1400                1405            

Glu Ser Val Arg Thr Tyr Asp Ser Asn Gly His Val Ser Ser Ala Lys 
    1410                1415                1420                

Val Ala Trp Asp Ala Ile Arg Pro Glu Gln Tyr Ala Lys Glu Gly Val 
1425                1430                1435                1440

Phe Thr Val Asn Gly Arg Leu Glu Gly Thr Gln Leu Thr Thr Lys Leu 
                1445                1450                1455    

His Val Arg Val Ser Ala Gln Thr Glu Gln Gly Ala Asn Ile Ser Asp 
            1460                1465                1470        

Gln Trp Thr Gly Ser Glu Leu Pro Leu Ala Phe Ala Ser Asp Ser Asn 
        1475                1480                1485            

Pro Ser Asp Pro Val Ser Asn Val Asn Asp Lys Leu Ile Ser Tyr Asn 
    1490                1495                1500                

Asn Gln Pro Ala Asn Arg Trp Thr Asn Trp Asn Arg Thr Asn Pro Glu 
1505                1510                1515                1520

Ala Ser Val Gly Val Leu Phe Gly Asp Ser Gly Ile Leu Ser Lys Arg 
                1525                1530                1535    

Ser Val Asp Asn Leu Ser Val Gly Phe His Glu Asp His Gly Val Gly 
            1540                1545                1550        

Val Pro Lys Ser Tyr Val Ile Glu Tyr Tyr Val Gly Lys Thr Val Pro 
        1555                1560                1565            

Thr Ala Pro Lys Asn Pro Ser Phe Val Gly Asn Glu Asp His Val Phe 
    1570                1575                1580                

Asn Asp Ser Ala Asn Trp Lys Pro Val Thr Asn Leu Lys Ala Pro Ala 
1585                1590                1595                1600

Gln Leu Lys Ala Gly Glu Met Asn His Phe Ser Phe Asp Lys Val Glu 
                1605                1610                1615    

Thr Tyr Ala Val Arg Ile Arg Met Val Lys Ala Asp Asn Lys Arg Gly 
            1620                1625                1630        

Thr Ser Ile Thr Glu Val Gln Ile Phe Ala Lys Gln Val Ala Ala Ala 
        1635                1640                1645            

Lys Gln Gly Gln Thr Arg Ile Gln Val Asp Gly Lys Asp Leu Ala Asn 
    1650                1655                1660                

Phe Asn Pro Asp Leu Thr Asp Tyr Tyr Leu Glu Ser Val Asp Gly Lys 
1665                1670                1675                1680

Val Pro Ala Val Thr Ala Ser Val Ser Asn Asn Gly Leu Ala Thr Val 
                1685                1690                1695    

Val Pro Ser Val Arg Glu Gly Glu Pro Val Arg Val Ile Ala Lys Ala 
            1700                1705                1710        

Glu Asn Gly Asp Ile Leu Gly Glu Tyr Arg Leu His Phe Thr Lys Asp 
        1715                1720                1725            

Lys Ser Leu Leu Ser His Lys Pro Val Ala Ala Val Lys Gln Ala Arg 
    1730                1735                1740                

Leu Leu Gln Val Gly Gln Ala Leu Glu Leu Pro Thr Lys Val Pro Val 
1745                1750                1755                1760

Tyr Phe Thr Gly Lys Asp Gly Tyr Glu Thr Lys Asp Leu Thr Val Glu 
                1765                1770                1775    

Trp Glu Glu Val Pro Ala Glu Asn Leu Thr Lys Ala Gly Gln Phe Thr 
            1780                1785                1790        

Val Arg Gly Arg Val Leu Gly Ser Asn Leu Val Ala Glu Ile Thr Val 
        1795                1800                1805            

Arg Val Thr Asp Lys Leu Gly Glu Thr Leu Ser Asp Asn Pro Asn Tyr 
    1810                1815                1820                

Asp Glu Asn Ser Asn Gln Ala Phe Ala Ser Ala Thr Asn Asp Ile Asp 
1825                1830                1835                1840

Lys Asn Ser His Asp Arg Val Asp Tyr Leu Asn Asp Gly Asp His Ser 
                1845                1850                1855    

Glu Asn Arg Arg Trp Thr Asn Trp Ser Pro Thr Pro Ser Ser Asn Pro 
            1860                1865                1870        

Glu Val Ser Ala Gly Val Ile Phe Arg Glu Asn Gly Lys Ile Val Glu 
        1875                1880                1885            

Arg Thr Val Thr Gln Gly Lys Val Gln Phe Phe Ala Asp Ser Gly Thr 
    1890                1895                1900                

Asp Ala Pro Ser Lys Leu Val Leu Glu Arg Tyr Val Gly Pro Glu Phe 
1905                1910                1915                1920

Glu Val Pro Thr Tyr Tyr Ser Asn Tyr Gln Ala Tyr Asp Ala Asp His 
                1925                1930                1935    

Pro Phe Asn Asn Pro Glu Asn Trp Glu Ala Val Pro Tyr Arg Ala Asp 
            1940                1945                1950        

Lys Asp Ile Ala Ala Gly Asp Glu Ile Asn Val Thr Phe Lys Ala Ile 
        1955                1960                1965            

Lys Ala Lys Ala Met Arg Trp Arg Met Glu Arg Lys Ala Asp Lys Ser 
    1970                1975                1980                

Gly Val Ala Met Ile Glu Met Thr Phe Leu Ala Pro Ser Glu Leu Pro 
1985                1990                1995                2000

Gln Glu Ser Thr Gln Ser Lys Ile Leu Val Asp Gly Lys Glu Leu Ala 
                2005                2010                2015    

Asp Phe Ala Glu Asn Arg Gln Asp Tyr Gln Ile Thr Tyr Lys Gly Gln 
            2020                2025                2030        

Arg Pro Lys Val Ser Val Glu Glu Asn Asn Gln Val Ala Ser Thr Val 
        2035                2040                2045            

Val Asp Ser Gly Glu Asp Ser Phe Pro Val Leu Val Arg Leu Val Ser 
    2050                2055                2060                

Glu Ser Gly Lys Gln Val Lys Glu Tyr Arg Ile His Leu Thr Lys Glu 
2065                2070                2075                2080

Lys Pro Val Ser Glu Lys Thr Val Ala Ala Val Gln Glu Asp Leu Pro 
                2085                2090                2095    

Lys Ile Glu Phe Val Glu Lys Asp Leu Ala Tyr Lys Thr Val Glu Lys 
            2100                2105                2110        

Lys Asp Ser Thr Leu Tyr Leu Gly Glu Thr Arg Val Glu Gln Glu Gly 
        2115                2120                2125            

Lys Val Gly Lys Glu Arg Ile Phe Thr Ala Ile Asn Pro Asp Gly Ser 
    2130                2135                2140                

Lys Glu Glu Lys Leu Arg Glu Val Val Glu Val Pro Thr Asp Arg Ile 
2145                2150                2155                2160

Val Leu Val Gly Thr Lys Pro Val Ala Gln Glu Ala Lys Lys Pro Gln 
                2165                2170                2175    

Val Ser Glu Lys Ala Asp Thr Lys Pro Ile Asp Ser Ser Glu Ala Ser 
            2180                2185                2190        

Gln Thr Asn Lys Ala Gln Leu Pro Ser Thr Gly Ser Ala Ala Ser Gln 
        2195                2200                2205            

Ala Ala Val Ala Ala Gly Leu Thr Leu Leu Gly Leu Ser Ala Gly Leu 
    2210                2215                2220                

Val Val Thr Lys Gly Lys Lys Glu Asp 
2225                2230            

<210>   67
<211>   332
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   67
Met Asn Lys Arg Leu Phe Ser Lys Met Ser Leu Val Thr Leu Pro Ile 
1               5                   10                  15      

Leu Ala Leu Phe Ser Gln Ser Val Leu Ala Glu Glu Asn Ile His Phe 
            20                  25                  30          

Ser Ser Cys Lys Glu Ala Trp Ala Asn Gly Tyr Ser Asp Ile His Glu 
        35                  40                  45              

Gly Glu Pro Gly Tyr Ser Ala Lys Leu Asp Arg Asp His Asp Gly Val 
    50                  55                  60                  

Ala Cys Glu Leu Lys Asn Ala Pro Lys Gly Ala Phe Lys Ala Lys Gln 
65                  70                  75                  80  

Ser Thr Ala Ile Gln Ile Asn Thr Ser Ser Ala Thr Thr Ser Gly Trp 
                85                  90                  95      

Val Lys Gln Asp Gly Ala Trp Tyr Tyr Phe Asp Gly Asn Gly Asn Leu 
            100                 105                 110         

Val Lys Asn Ala Trp Gln Gly Ser Tyr Tyr Leu Lys Ala Asp Gly Lys 
        115                 120                 125             

Met Ala Gln Ser Glu Trp Ile Tyr Asp Ser Ser Tyr Gln Ala Trp Tyr 
    130                 135                 140                 

Tyr Leu Lys Ser Asp Gly Ser Tyr Ala Lys Asn Ala Trp Gln Gly Ala 
145                 150                 155                 160 

Tyr Tyr Leu Lys Ser Asn Gly Lys Met Ala Gln Gly Glu Trp Val Tyr 
                165                 170                 175     

Asp Ser Ser Tyr Gln Ala Trp Tyr Tyr Leu Lys Ser Asp Gly Ser Tyr 
            180                 185                 190         

Ala Arg Asn Ala Trp Gln Gly Asn Tyr Tyr Leu Lys Ser Asp Gly Lys 
        195                 200                 205             

Met Ala Lys Gly Glu Trp Val Tyr Asp Ala Thr Tyr Gln Ala Trp Tyr 
    210                 215                 220                 

Tyr Leu Thr Ser Asp Gly Ser Tyr Ala Tyr Ser Thr Trp Gln Gly Asn 
225                 230                 235                 240 

Tyr Tyr Leu Lys Ser Asp Gly Lys Met Ala Val Asn Glu Trp Val Asp 
                245                 250                 255     

Gly Gly Arg Tyr Tyr Val Gly Ala Asp Gly Val Trp Lys Glu Val Gln 
            260                 265                 270         

Ala Ser Thr Ala Ser Ser Ser Asn Asp Ser Asn Ser Glu Tyr Ser Ala 
        275                 280                 285             

Ala Leu Gly Lys Ala Lys Ser Tyr Asn Ser Leu Phe His Met Ser Lys 
    290                 295                 300                 

Lys Arg Met Tyr Arg Gln Leu Thr Ser Asp Phe Asp Lys Phe Ser Asn 
305                 310                 315                 320 

Asp Ala Ala Gln Tyr Ala Ile Asp His Leu Asp Asp 
                325                 330         

<210>   68
<211>   450
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   68
Met Lys Val Ile Asp Gln Phe Lys Asn Lys Lys Val Leu Val Leu Gly 
1               5                   10                  15      

Leu Ala Lys Ser Gly Glu Ser Ala Ala Arg Leu Leu Asp Lys Leu Gly 
            20                  25                  30          

Ala Ile Val Thr Val Asn Asp Gly Lys Pro Phe Glu Asp Asn Pro Ala 
        35                  40                  45              

Ala Gln Ser Leu Leu Glu Glu Gly Ile Lys Val Ile Thr Gly Gly His 
    50                  55                  60                  

Pro Leu Glu Leu Leu Asp Glu Glu Phe Ala Leu Met Val Lys Asn Pro 
65                  70                  75                  80  

Gly Ile Pro Tyr Asn Asn Pro Met Ile Glu Lys Ala Leu Ala Lys Gly 
                85                  90                  95      

Ile Pro Val Leu Thr Glu Val Glu Leu Ala Tyr Leu Ile Ser Glu Ala 
            100                 105                 110         

Pro Ile Ile Gly Ile Thr Gly Ser Asn Gly Lys Thr Thr Thr Thr Thr 
        115                 120                 125             

Met Ile Gly Glu Val Leu Thr Ala Ala Gly Gln His Gly Leu Leu Ser 
    130                 135                 140                 

Gly Asn Ile Gly Tyr Pro Ala Ser Gln Val Ala Gln Ile Ala Ser Asp 
145                 150                 155                 160 

Lys Asp Thr Leu Val Met Glu Leu Ser Ser Phe Gln Leu Met Gly Val 
                165                 170                 175     

Gln Glu Phe His Pro Glu Ile Ala Val Ile Thr Asn Leu Met Pro Thr 
            180                 185                 190         

His Ile Asp Tyr His Gly Ser Phe Ser Glu Tyr Val Ala Ala Lys Trp 
        195                 200                 205             

Asn Ile Gln Asn Lys Met Thr Ala Ala Asp Phe Leu Val Leu Asn Phe 
    210                 215                 220                 

Asn Gln Asp Leu Ala Lys Asp Leu Thr Ser Lys Thr Glu Ala Thr Val 
225                 230                 235                 240 

Val Pro Phe Ser Thr Leu Glu Lys Val Asp Gly Ala Tyr Leu Glu Asp 
                245                 250                 255     

Gly Gln Leu Tyr Phe Arg Gly Glu Val Val Met Ala Ala Asn Glu Ile 
            260                 265                 270         

Gly Val Pro Gly Ser His Asn Val Glu Asn Ala Leu Ala Thr Ile Ala 
        275                 280                 285             

Val Ala Lys Leu Arg Asp Val Asp Asn Gln Thr Ile Lys Glu Thr Leu 
    290                 295                 300                 

Ser Ala Phe Gly Gly Val Lys His Arg Leu Gln Phe Val Asp Asp Ile 
305                 310                 315                 320 

Lys Gly Val Lys Phe Tyr Asn Asp Ser Lys Ser Thr Asn Ile Leu Ala 
                325                 330                 335     

Thr Gln Lys Ala Leu Ser Gly Phe Asp Asn Ser Lys Val Val Leu Ile 
            340                 345                 350         

Ala Gly Gly Leu Asp Arg Gly Asn Glu Phe Asp Glu Leu Val Pro Asp 
        355                 360                 365             

Ile Thr Gly Leu Lys Lys Met Val Ile Leu Gly Gln Ser Ala Glu Arg 
    370                 375                 380                 

Val Lys Arg Ala Ala Asp Lys Ala Gly Val Ala Tyr Val Glu Ala Thr 
385                 390                 395                 400 

Asp Ile Ala Asp Ala Thr Arg Lys Ala Tyr Glu Leu Ala Thr Gln Gly 
                405                 410                 415     

Asp Val Val Leu Leu Ser Pro Ala Asn Ala Ser Trp Asp Met Tyr Ala 
            420                 425                 430         

Asn Phe Glu Val Arg Gly Asp Leu Phe Ile Asp Thr Val Ala Glu Leu 
        435                 440                 445             

Lys Glu 
    450 

<210>   69
<211>   386
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   69
Met Lys Lys Lys Phe Ala Leu Ser Phe Val Ala Leu Ala Ser Val Ala 
1               5                   10                  15      

Leu Leu Ala Ala Cys Gly Glu Val Lys Ser Gly Ala Val Asn Thr Ala 
            20                  25                  30          

Gly Asn Ser Val Glu Glu Lys Thr Ile Lys Ile Gly Phe Asn Phe Glu 
        35                  40                  45              

Glu Ser Gly Ser Leu Ala Ala Tyr Gly Thr Ala Glu Gln Lys Gly Ala 
    50                  55                  60                  

Gln Leu Ala Val Asp Glu Ile Asn Ala Ala Gly Gly Ile Asp Gly Lys 
65                  70                  75                  80  

Gln Ile Glu Val Val Asp Lys Asp Asn Lys Ser Glu Thr Ala Glu Ala 
                85                  90                  95      

Ala Ser Val Thr Thr Asn Leu Val Thr Gln Ser Lys Val Ser Ala Val 
            100                 105                 110         

Val Gly Pro Ala Thr Ser Gly Ala Thr Ala Ala Ala Val Ala Asn Ala 
        115                 120                 125             

Thr Lys Ala Gly Val Pro Leu Ile Ser Pro Ser Ala Thr Gln Asp Gly 
    130                 135                 140                 

Leu Thr Lys Gly Gln Asp Tyr Leu Phe Ile Gly Thr Phe Gln Asp Ser 
145                 150                 155                 160 

Phe Gln Gly Lys Ile Ile Ser Asn Tyr Val Ser Glu Lys Leu Asn Ala 
                165                 170                 175     

Lys Lys Val Val Leu Tyr Thr Asp Asn Ala Ser Asp Tyr Ala Lys Gly 
            180                 185                 190         

Ile Ala Lys Ser Phe Arg Glu Ser Tyr Lys Gly Glu Ile Val Ala Asp 
        195                 200                 205             

Glu Thr Phe Val Ala Gly Asp Thr Asp Phe Gln Ala Ala Leu Thr Lys 
    210                 215                 220                 

Met Lys Gly Lys Asp Phe Asp Ala Ile Val Val Pro Gly Tyr Tyr Asn 
225                 230                 235                 240 

Glu Ala Gly Lys Ile Val Asn Gln Ala Arg Gly Met Gly Ile Asp Lys 
                245                 250                 255     

Pro Ile Val Gly Gly Asp Gly Phe Asn Gly Glu Glu Phe Val Gln Gln 
            260                 265                 270         

Ala Thr Ala Glu Lys Ala Ser Asn Ile Tyr Phe Ile Ser Gly Phe Ser 
        275                 280                 285             

Thr Thr Val Glu Val Ser Ala Lys Ala Lys Ala Phe Leu Asp Ala Tyr 
    290                 295                 300                 

Arg Ala Lys Tyr Asn Glu Glu Pro Ser Thr Phe Ala Ala Leu Ala Tyr 
305                 310                 315                 320 

Asp Ser Val His Leu Val Ala Asn Ala Ala Lys Gly Ala Lys Asn Ser 
                325                 330                 335     

Gly Glu Ile Lys Asn Asn Leu Ala Lys Thr Lys Asp Phe Glu Gly Val 
            340                 345                 350         

Thr Gly Gln Thr Ser Phe Asp Ala Asp His Asn Thr Val Lys Thr Ala 
        355                 360                 365             

Tyr Met Met Thr Met Asn Asn Gly Lys Val Glu Ala Ala Glu Val Val 
    370                 375                 380                 

Lys Pro 
385     

<210>   70
<211>   513
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   70
Met Ser Ile Leu Glu Val Lys Asn Leu Ser His Gly Phe Gly Asp Arg 
1               5                   10                  15      

Ala Ile Phe Glu Asp Val Ser Phe Arg Leu Leu Lys Gly Glu His Ile 
            20                  25                  30          

Gly Leu Val Gly Ala Asn Gly Glu Gly Lys Ser Thr Phe Met Ser Ile 
        35                  40                  45              

Val Thr Gly Lys Met Leu Pro Asp Glu Gly Lys Val Glu Trp Ser Lys 
    50                  55                  60                  

Tyr Val Thr Ala Gly Tyr Leu Asp Gln His Ser Val Leu Ala Glu Arg 
65                  70                  75                  80  

Gln Ser Val Arg Asp Val Leu Arg Thr Ala Phe Asp Glu Leu Phe Lys 
                85                  90                  95      

Ala Glu Ala Arg Ile Asn Asp Leu Tyr Met Lys Met Ala Glu Asp Gly 
            100                 105                 110         

Ala Asp Val Asp Ala Leu Met Glu Glu Val Gly Glu Leu Gln Asp Arg 
        115                 120                 125             

Leu Glu Ser Arg Asp Phe Tyr Thr Leu Asp Ala Lys Ile Asp Glu Val 
    130                 135                 140                 

Ala Arg Ala Leu Gly Val Met Asp Phe Gly Met Asp Thr Asp Val Thr 
145                 150                 155                 160 

Ser Leu Ser Gly Gly Gln Arg Thr Lys Val Leu Leu Ala Lys Leu Leu 
                165                 170                 175     

Leu Glu Lys Pro Asp Ile Leu Leu Leu Asp Glu Pro Thr Asn Tyr Leu 
            180                 185                 190         

Asp Ala Glu His Ile Asp Trp Leu Lys Arg Tyr Leu Gln Asn Tyr Glu 
        195                 200                 205             

Asn Ala Phe Val Leu Ile Ser His Asp Ile Pro Phe Leu Asn Asp Val 
    210                 215                 220                 

Ile Asn Ile Val Tyr His Val Glu Asn Gln Gln Leu Thr Arg Tyr Ser 
225                 230                 235                 240 

Gly Asp Tyr Tyr Gln Phe Gln Glu Val Tyr Ala Met Lys Lys Ser Gln 
                245                 250                 255     

Leu Glu Ala Ala Tyr Glu Arg Gln Gln Lys Glu Ile Ala Asp Leu Lys 
            260                 265                 270         

Asp Phe Val Ala Arg Asn Lys Ala Arg Val Ala Thr Arg Asn Met Ala 
        275                 280                 285             

Met Ser Arg Gln Lys Lys Leu Asp Lys Met Asp Ile Ile Glu Leu Gln 
    290                 295                 300                 

Ser Glu Lys Pro Lys Pro Ser Phe Asp Phe Lys Pro Ala Arg Thr Pro 
305                 310                 315                 320 

Gly Arg Phe Ile Phe Gln Ala Lys Asn Leu Gln Ile Gly Tyr Asp Arg 
                325                 330                 335     

Pro Leu Thr Lys Pro Leu Asn Leu Thr Phe Glu Arg Asn Gln Lys Val 
            340                 345                 350         

Ala Ile Ile Gly Ala Asn Gly Ile Gly Lys Thr Thr Leu Leu Lys Ser 
        355                 360                 365             

Leu Leu Gly Ile Ile Ser Pro Ile Ala Gly Glu Val Glu Arg Gly Asp 
    370                 375                 380                 

Tyr Leu Glu Leu Gly Tyr Phe Glu Gln Glu Val Glu Gly Gly Asn Arg 
385                 390                 395                 400 

Gln Thr Pro Leu Glu Ala Val Trp Asn Ala Phe Pro Ala Leu Asn Gln 
                405                 410                 415     

Ala Glu Val Arg Ala Ala Leu Ala Arg Cys Gly Leu Thr Thr Lys His 
            420                 425                 430         

Ile Glu Ser Gln Ile Gln Val Leu Ser Gly Gly Glu Gln Ala Lys Val 
        435                 440                 445             

Arg Phe Cys Leu Leu Met Asn Arg Glu Asn Asn Val Leu Val Leu Asp 
    450                 455                 460                 

Glu Pro Thr Asn His Leu Asp Val Asp Ala Lys Asp Glu Leu Lys Arg 
465                 470                 475                 480 

Ala Leu Lys Glu Tyr Arg Gly Ser Ile Leu Met Val Cys His Glu Pro 
                485                 490                 495     

Asp Phe Tyr Glu Gly Trp Ile Asp Gln Ile Trp Asp Phe Asn Asn Leu 
            500                 505                 510         

Thr 
    

<210>   71
<211>   399
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   71
Met Lys Lys Lys Asn Gly Lys Ala Lys Lys Trp Gln Leu Tyr Ala Ala 
1               5                   10                  15      

Ile Gly Ala Ala Ser Val Val Val Leu Gly Ala Gly Gly Ile Leu Leu 
            20                  25                  30          

Phe Arg Gln Pro Ser Gln Thr Ala Leu Lys Asp Glu Pro Thr His Leu 
        35                  40                  45              

Val Val Ala Lys Glu Gly Ser Val Ala Ser Ser Val Leu Leu Ser Gly 
    50                  55                  60                  

Thr Val Thr Ala Lys Asn Glu Gln Tyr Val Tyr Phe Asp Ala Ser Lys 
65                  70                  75                  80  

Gly Asp Leu Asp Glu Ile Leu Val Ser Val Gly Asp Lys Val Ser Glu 
                85                  90                  95      

Gly Gln Ala Leu Val Lys Tyr Ser Ser Ser Glu Ala Gln Ala Ala Tyr 
            100                 105                 110         

Asp Ser Ala Ser Arg Ala Val Ala Arg Ala Asp Arg His Ile Asn Glu 
        115                 120                 125             

Leu Asn Gln Ala Arg Asn Glu Ala Ala Ser Ala Pro Ala Pro Gln Leu 
    130                 135                 140                 

Pro Ala Pro Val Gly Gly Glu Asp Ala Thr Val Gln Ser Pro Thr Pro 
145                 150                 155                 160 

Val Ala Gly Asn Ser Val Ala Ser Ile Asp Ala Gln Leu Gly Asp Ala 
                165                 170                 175     

Arg Asp Ala Arg Ala Asp Ala Ala Ala Gln Leu Ser Lys Ala Gln Ser 
            180                 185                 190         

Gln Leu Asp Ala Thr Thr Val Leu Ser Thr Leu Glu Gly Thr Val Val 
        195                 200                 205             

Glu Val Asn Ser Asn Val Ser Lys Ser Pro Thr Gly Ala Ser Gln Val 
    210                 215                 220                 

Met Val His Ile Val Ser Asn Glu Asn Leu Gln Val Lys Gly Glu Leu 
225                 230                 235                 240 

Ser Glu Tyr Asn Leu Ala Asn Leu Ser Val Gly Gln Glu Val Ser Phe 
                245                 250                 255     

Thr Ser Lys Val Tyr Pro Asp Lys Lys Trp Thr Gly Lys Leu Ser Tyr 
            260                 265                 270         

Ile Ser Asp Tyr Pro Lys Asn Asn Gly Glu Ala Ala Ser Pro Ala Ala 
        275                 280                 285             

Gly Asn Asn Thr Gly Ser Lys Tyr Pro Tyr Thr Ile Asp Val Thr Gly 
    290                 295                 300                 

Glu Val Gly Asp Leu Lys Gln Gly Phe Ser Val Asn Ile Glu Val Lys 
305                 310                 315                 320 

Ser Lys Thr Lys Ala Ile Leu Val Pro Val Ser Ser Leu Val Met Asp 
                325                 330                 335     

Asp Ser Lys Asn Tyr Val Trp Ile Val Asp Glu Gln Gln Lys Ala Lys 
            340                 345                 350         

Lys Val Glu Val Ser Leu Gly Asn Ala Asp Ala Glu Asn Gln Glu Ile 
        355                 360                 365             

Thr Ser Gly Leu Thr Asn Gly Ala Lys Val Ile Ser Asn Pro Thr Ser 
    370                 375                 380                 

Ser Leu Glu Glu Gly Lys Glu Val Lys Ala Asp Glu Ala Thr Asn 
385                 390                 395                 

<210>   72
<211>   230
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   72
Ser Glu Thr Asn His Glu Ile Asp Ser Asn Phe Ala Gly Arg Leu Asn 
1               5                   10                  15      

Ile Leu Arg Ala Gly Val Leu Asp Ala Asn Asp Gly Ile Ile Ser Ile 
            20                  25                  30          

Ala Gly Val Val Ile Gly Val Ala Ser Ala Thr Thr Asn Ile Trp Ile 
        35                  40                  45              

Ile Phe Leu Ser Gly Phe Thr Ala Ile Leu Ala Gly Ala Phe Ser Met 
    50                  55                  60                  

Ala Gly Gly Glu Tyr Val Ser Val Ser Thr Pro Lys Asp Thr Glu Glu 
65                  70                  75                  80  

Ala Ala Val Ser Arg Glu Lys Leu Leu Leu Asp Gln Asp Arg Glu Leu 
                85                  90                  95      

Ala Lys Lys Ser Leu Tyr Ala Ala Tyr Ile Gln Asn Gly Glu Phe Lys 
            100                 105                 110         

Thr Ser Ala Gln Leu Leu Thr Asn Lys Ile Phe Leu Lys Asn Pro Leu 
        115                 120                 125             

Lys Ala Leu Val Glu Glu Lys Tyr Gly Ile Glu Tyr Glu Glu Phe Thr 
    130                 135                 140                 

Asn Pro Trp His Ala Ala Ile Ser Ser Phe Val Ala Phe Phe Leu Arg 
145                 150                 155                 160 

Ser Leu Pro Pro Met Leu Ser Val Thr Ile Phe Pro Ser Asp Tyr Arg 
                165                 170                 175     

Ile Pro Ala Thr Val Leu Ile Val Gly Val Ala Leu Leu Leu Thr Gly 
            180                 185                 190         

Tyr Thr Ser Ala Arg Leu Gly Lys Ala Pro Thr Lys Thr Ala Met Ile 
        195                 200                 205             

Arg Asn Leu Ala Ile Gly Leu Leu Thr Met Gly Val Thr Phe Leu Leu 
    210                 215                 220                 

Gly Gln Leu Phe Ser Ile 
225                 230 

<210>   73
<211>   627
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   73
Met Lys Lys Lys Leu Thr Ser Leu Ala Leu Val Gly Ala Phe Leu Gly 
1               5                   10                  15      

Leu Ser Trp Tyr Gly Asn Val Gln Ala Gln Glu Ser Ser Gly Asn Lys 
            20                  25                  30          

Ile His Phe Ile Asn Val Gln Glu Gly Gly Ser Asp Ala Ile Ile Leu 
        35                  40                  45              

Glu Ser Asn Gly His Phe Ala Met Val Asp Thr Gly Glu Asp Tyr Asp 
    50                  55                  60                  

Phe Pro Asp Gly Ser Asp Ser Arg Tyr Pro Trp Arg Glu Gly Ile Glu 
65                  70                  75                  80  

Thr Ser Tyr Lys His Val Leu Thr Asp Arg Val Phe Arg Arg Leu Lys 
                85                  90                  95      

Glu Leu Gly Val Gln Lys Leu Asp Phe Ile Leu Val Thr His Thr His 
            100                 105                 110         

Ser Asp His Ile Gly Asn Val Asp Glu Leu Leu Ser Thr Tyr Pro Val 
        115                 120                 125             

Asp Arg Val Tyr Leu Lys Lys Tyr Ser Asp Ser Arg Ile Thr Asn Ser 
    130                 135                 140                 

Glu Arg Leu Trp Asp Asn Leu Tyr Gly Tyr Asp Lys Val Leu Gln Thr 
145                 150                 155                 160 

Ala Ala Glu Lys Gly Val Ser Val Ile Gln Asn Ile Thr Gln Gly Asp 
                165                 170                 175     

Ala His Phe Gln Phe Gly Asp Met Asp Ile Gln Leu Tyr Asn Tyr Glu 
            180                 185                 190         

Asn Glu Thr Asp Ser Ser Gly Glu Leu Lys Lys Ile Trp Asp Asp Asn 
        195                 200                 205             

Ser Asn Ser Leu Ile Ser Val Val Lys Val Asn Gly Lys Lys Ile Tyr 
    210                 215                 220                 

Leu Gly Gly Asp Leu Asp Asn Val His Gly Ala Glu Asp Lys Tyr Gly 
225                 230                 235                 240 

Pro Leu Ile Gly Lys Val Asp Leu Met Lys Phe Asn His His His Asp 
                245                 250                 255     

Thr Asn Lys Ser Asn Thr Lys Asp Phe Ile Lys Asn Leu Ser Pro Ser 
            260                 265                 270         

Leu Ile Val Gln Thr Ser Asp Ser Leu Pro Trp Lys Asn Gly Val Asp 
        275                 280                 285             

Ser Glu Tyr Val Asn Trp Leu Lys Glu Arg Gly Ile Glu Arg Ile Asn 
    290                 295                 300                 

Ala Ala Ser Lys Asp Tyr Asp Ala Thr Val Phe Asp Ile Arg Lys Asp 
305                 310                 315                 320 

Gly Phe Val Asn Ile Ser Thr Ser Tyr Lys Pro Ile Pro Ser Phe Gln 
                325                 330                 335     

Ala Gly Trp His Lys Ser Ala Tyr Gly Asn Trp Trp Tyr Gln Ala Pro 
            340                 345                 350         

Asp Ser Thr Gly Glu Tyr Ala Val Gly Trp Asn Glu Ile Glu Gly Glu 
        355                 360                 365             

Trp Tyr Tyr Phe Asn Gln Thr Gly Ile Leu Leu Gln Asn Gln Trp Lys 
    370                 375                 380                 

Lys Trp Asn Asn His Trp Phe Tyr Leu Thr Asp Ser Gly Ala Ser Ala 
385                 390                 395                 400 

Lys Asn Trp Lys Lys Ile Ala Gly Ile Trp Tyr Tyr Phe Asn Lys Glu 
                405                 410                 415     

Asn Gln Met Glu Ile Gly Trp Ile Gln Asp Lys Glu Gln Trp Tyr Tyr 
            420                 425                 430         

Leu Asp Val Asp Gly Ser Met Lys Thr Gly Trp Leu Gln Tyr Met Gly 
        435                 440                 445             

Gln Trp Tyr Tyr Phe Ala Pro Ser Gly Glu Met Lys Met Gly Trp Val 
    450                 455                 460                 

Lys Asp Lys Glu Thr Trp Tyr Tyr Met Asp Ser Thr Gly Val Met Lys 
465                 470                 475                 480 

Thr Gly Glu Ile Glu Val Ala Gly Gln His Tyr Tyr Leu Glu Asp Ser 
                485                 490                 495     

Gly Ala Met Lys Gln Gly Trp His Lys Lys Ala Asn Asp Trp Tyr Phe 
            500                 505                 510         

Tyr Lys Thr Asp Gly Ser Arg Ala Val Gly Trp Ile Lys Asp Lys Asp 
        515                 520                 525             

Lys Trp Tyr Phe Leu Lys Glu Asn Gly Gln Leu Leu Val Asn Gly Lys 
    530                 535                 540                 

Thr Pro Glu Gly Tyr Thr Val Asp Ser Ser Gly Ala Trp Leu Val Asp 
545                 550                 555                 560 

Val Ser Ile Glu Lys Ser Ala Thr Ile Lys Thr Thr Ser His Ser Glu 
                565                 570                 575     

Ile Lys Glu Ser Lys Glu Val Val Lys Lys Asp Leu Glu Asn Lys Glu 
            580                 585                 590         

Thr Ser Gln His Glu Ser Val Thr Asn Phe Ser Thr Ser Gln Asp Leu 
        595                 600                 605             

Thr Ser Ser Thr Ser Gln Ser Ser Glu Thr Ser Val Asn Lys Ser Glu 
    610                 615                 620                 

Ser Glu Gln 
625         

<210>   74
<211>   456
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   74
Met Asp Leu Gly Pro Thr Gln Arg Gly Ile Ser Val Val Ser Gln Ser 
1               5                   10                  15      

Tyr Ile Asn Val Ile Gly Ala Gly Leu Ala Gly Ser Glu Ala Ala Tyr 
            20                  25                  30          

Gln Ile Ala Glu Arg Gly Ile Pro Val Lys Leu Tyr Glu Met Arg Gly 
        35                  40                  45              

Val Lys Ser Thr Pro Gln His Lys Thr Asp Asn Phe Ala Glu Leu Val 
    50                  55                  60                  

Cys Ser Asn Ser Leu Arg Gly Asp Ala Leu Thr Asn Ala Val Gly Leu 
65                  70                  75                  80  

Leu Lys Glu Glu Met Arg Arg Leu Gly Ser Val Ile Leu Glu Ser Ala 
                85                  90                  95      

Glu Ala Thr Arg Val Pro Ala Gly Gly Ala Leu Ala Val Asp Arg Asp 
            100                 105                 110         

Gly Phe Ser Gln Met Val Thr Glu Lys Val Ala Asn His Pro Leu Ile 
        115                 120                 125             

Glu Val Val Arg Asp Glu Ile Thr Glu Leu Pro Thr Asp Val Ile Thr 
    130                 135                 140                 

Val Ile Ala Thr Gly Pro Leu Thr Ser Asp Ala Leu Ala Glu Lys Ile 
145                 150                 155                 160 

His Ala Leu Asn Asp Gly Ala Gly Phe Tyr Phe Tyr Asp Ala Ala Ala 
                165                 170                 175     

Pro Ile Ile Asp Val Asn Thr Ile Asp Met Ser Lys Val Tyr Leu Lys 
            180                 185                 190         

Ser Arg Tyr Asp Lys Gly Glu Ala Ala Tyr Leu Asn Ala Pro Met Thr 
        195                 200                 205             

Lys Gln Glu Phe Met Asp Phe His Glu Ala Leu Val Asn Ala Glu Glu 
    210                 215                 220                 

Ala Pro Leu Ser Ser Phe Glu Lys Glu Lys Tyr Phe Glu Gly Cys Met 
225                 230                 235                 240 

Pro Ile Glu Val Met Ala Lys Arg Gly Ile Lys Thr Met Leu Tyr Gly 
                245                 250                 255     

Pro Met Lys Pro Val Gly Leu Glu Tyr Pro Asp Asp Tyr Thr Gly Pro 
            260                 265                 270         

Arg Asp Gly Glu Phe Lys Thr Pro Tyr Ala Val Val Gln Leu Arg Gln 
        275                 280                 285             

Asp Asn Ala Ala Gly Ser Leu Tyr Asn Ile Val Gly Phe Gln Thr His 
    290                 295                 300                 

Leu Lys Trp Gly Glu Gln Lys Arg Val Phe Gln Met Ile Pro Gly Leu 
305                 310                 315                 320 

Glu Asn Ala Glu Phe Val Arg Tyr Gly Val Met His Arg Asn Ser Tyr 
                325                 330                 335     

Met Asp Ser Pro Asn Leu Leu Glu Gln Thr Tyr Arg Ser Lys Lys Gln 
            340                 345                 350         

Pro Asn Leu Phe Phe Ala Gly Gln Met Thr Gly Val Glu Gly Tyr Val 
        355                 360                 365             

Glu Ser Ala Ala Ser Gly Leu Val Ala Gly Ile Asn Ala Ala Arg Leu 
    370                 375                 380                 

Phe Lys Glu Glu Ser Glu Ala Ile Phe Pro Glu Thr Thr Ala Ile Gly 
385                 390                 395                 400 

Ser Leu Ala His Tyr Ile Thr His Ala Asp Ser Lys His Phe Gln Pro 
                405                 410                 415     

Met Asn Val Asn Phe Gly Ile Ile Lys Glu Leu Glu Gly Glu Arg Ile 
            420                 425                 430         

Arg Asp Lys Lys Ala Arg Tyr Glu Lys Ile Ala Glu Arg Ala Leu Ala 
        435                 440                 445             

Asp Leu Glu Glu Phe Leu Thr Val 
    450                 455     

<210>   75
<211>   360
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   75
Met Leu Ile Gly Ile Pro Lys Glu Ile Lys Asn Asn Glu Asn Arg Val 
1               5                   10                  15      

Ala Leu Thr Pro Ala Gly Val His Ser Leu Val Ser Arg Gly His Arg 
            20                  25                  30          

Val Leu Ile Glu Thr Asn Ala Gly Leu Gly Ser Gly Phe Thr Asp Ala 
        35                  40                  45              

Asp Tyr Gln Lys Gln Gly Ala Glu Ile Val Ala Thr Ala Gly Glu Ala 
    50                  55                  60                  

Trp Ala Ala Glu Leu Val Val Lys Val Lys Glu Ser Leu Ser Ser Glu 
65                  70                  75                  80  

Tyr Gly Tyr Leu Arg Asp Asp Leu Leu Leu Phe Thr Tyr Leu His Met 
                85                  90                  95      

Ala Ala Ala Pro Glu Leu Ala Asp Ala Met Leu Thr Ala Lys Thr Thr 
            100                 105                 110         

Glu Thr Val Arg Asp Asn Gln Gly Gln Leu Pro Leu Leu Val Pro Met 
        115                 120                 125             

Ser Glu Val Ala Gly Arg Met Ala Val Gln Ile Gly Ala His Phe Leu 
    130                 135                 140                 

Thr Lys Gln Ala Gly Gly Ser Gly Val Leu Leu Gly Gly Val Pro Gly 
145                 150                 155                 160 

Val Pro Lys Gly Lys Val Thr Ile Ile Gly Gly Gly Val Val Gly Thr 
                165                 170                 175     

His Ala Ala Arg Ile Ala Leu Gly Leu Gly Ala Gln Val Thr Ile Leu 
            180                 185                 190         

Asp Ile Ser Ser Lys Arg Leu Ser Val Leu Glu Glu Val Phe Gly Ser 
        195                 200                 205             

Gln Ile Gln Thr Leu Met Ser Asn Ser Phe Asn Ile Glu Ala Ser Val 
    210                 215                 220                 

Arg Asp Ala Asp Val Val Ile Gly Ala Ile Leu Ile Pro Gly Ala Lys 
225                 230                 235                 240 

Ala Pro Glu Leu Val Thr Asp Glu Met Val Lys Gln Met Arg Pro Gly 
                245                 250                 255     

Ser Val Ser Leu Thr Leu Leu Leu Thr Lys Val Ala Leu Ser Lys Gln 
            260                 265                 270         

Leu Thr Val Gln Arg Thr Met Asn Pro Ser Met Lys Asn Thr Val Phe 
        275                 280                 285             

Ser Thr Met Pro Leu Pro Ile Ser Leu Val Arg Leu Leu Ala Leu Gln 
    290                 295                 300                 

Pro Ser Pro Pro Met Ser Leu Phe Leu Ile Ser Lys Leu Trp Leu Ala 
305                 310                 315                 320 

Lys Asp Ser His Lys Gln Ser Leu Lys Met Lys Ala Cys Val Lys Val 
                325                 330                 335     

Leu Leu Ile Lys Val Thr Leu Thr Tyr Gln Leu Leu Lys Asp Leu Ile 
            340                 345                 350         

Val Thr Thr Leu Ile Ser Met Ile 
        355                 360 

<210>   76
<211>   477
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   76
Met Lys Ile Leu Phe Val Ala Ala Glu Gly Ala Pro Phe Ser Lys Thr 
1               5                   10                  15      

Gly Gly Leu Gly Asp Val Ile Gly Ala Leu Pro Lys Ser Leu Val Lys 
            20                  25                  30          

Ala Gly His Glu Val Ala Val Ile Leu Pro Tyr Tyr Asp Met Val Glu 
        35                  40                  45              

Ala Lys Phe Gly Asn Gln Ile Glu Asp Val Leu His Phe Glu Val Ser 
    50                  55                  60                  

Val Gly Trp Arg Arg Gln Tyr Cys Gly Ile Lys Lys Thr Val Leu Asn 
65                  70                  75                  80  

Gly Val Thr Phe Tyr Phe Ile Asp Asn Gln Tyr Tyr Phe Phe Arg Gly 
                85                  90                  95      

His Val Tyr Gly Asp Phe Asp Asp Gly Glu Arg Phe Ala Phe Phe Gln 
            100                 105                 110         

Leu Ala Ala Ile Glu Ala Met Glu Arg Ile Asp Phe Ile Pro Asp Leu 
        115                 120                 125             

Leu His Val His Asp Tyr His Thr Ala Met Ile Pro Phe Leu Leu Lys 
    130                 135                 140                 

Glu Lys Tyr Arg Trp Ile Gln Ala Tyr Glu Asp Ile Glu Thr Val Leu 
145                 150                 155                 160 

Thr Ile His Asn Leu Glu Phe Gln Gly Gln Phe Ser Glu Gly Met Leu 
                165                 170                 175     

Gly Asp Leu Phe Gly Val Gly Phe Glu Arg Tyr Ala Asp Gly Thr Leu 
            180                 185                 190         

Arg Trp Asn Asn Cys Leu Asn Trp Met Lys Ala Gly Ile Leu Tyr Ala 
        195                 200                 205             

Asn Arg Val Ser Thr Val Ser Pro Ser Tyr Ala His Glu Ile Met Thr 
    210                 215                 220                 

Ser Gln Phe Gly Cys Asn Leu Asp Gln Ile Leu Lys Met Glu Ser Gly 
225                 230                 235                 240 

Lys Val Ser Gly Ile Val Asn Gly Ile Asp Ala Asp Leu Tyr Asn Pro 
                245                 250                 255     

Gln Thr Asp Ala Leu Leu Asp Tyr His Phe Asn Gln Glu Asp Leu Ser 
            260                 265                 270         

Gly Lys Ala Lys Asn Lys Ala Lys Leu Gln Glu Arg Val Gly Leu Pro 
        275                 280                 285             

Val Arg Ala Asp Val Pro Leu Val Gly Ile Val Ser Arg Leu Thr Arg 
    290                 295                 300                 

Gln Lys Gly Phe Asp Val Val Val Glu Ser Leu His His Ile Leu Gln 
305                 310                 315                 320 

Glu Asp Val Gln Ile Val Leu Leu Gly Thr Gly Asp Pro Ala Phe Glu 
                325                 330                 335     

Gly Ala Phe Ser Trp Phe Ala Gln Ile Tyr Pro Asp Lys Leu Ser Thr 
            340                 345                 350         

Asn Ile Thr Phe Asp Val Lys Leu Ala Gln Glu Ile Tyr Ala Ala Cys 
        355                 360                 365             

Asp Leu Phe Leu Met Pro Ser Arg Phe Glu Pro Cys Gly Leu Ser Gln 
    370                 375                 380                 

Met Met Ala Met Arg Tyr Gly Thr Leu Pro Leu Val His Glu Val Gly 
385                 390                 395                 400 

Gly Leu Arg Asp Thr Val Arg Ala Phe Asn Pro Ile Glu Gly Ser Gly 
                405                 410                 415     

Thr Gly Phe Ser Phe Asp Asn Leu Ser Pro Tyr Trp Leu Asn Trp Thr 
            420                 425                 430         

Phe Gln Thr Ala Leu Asp Leu Tyr Arg Asn His Pro Asp Ile Trp Arg 
        435                 440                 445             

Asn Leu Gln Lys Gln Ala Met Glu Ser Asp Phe Ser Trp Asp Thr Ala 
    450                 455                 460                 

Cys Lys Ser Tyr Leu Asp Leu Tyr His Ser Leu Val Asn 
465                 470                 475         

<210>   77
<211>   2004
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   77
Met Glu Lys Tyr Phe Gly Glu Lys Gln Glu Arg Phe Ser Phe Arg Lys 
1               5                   10                  15      

Leu Ser Val Gly Leu Val Ser Ala Thr Ile Ser Ser Leu Phe Phe Met 
            20                  25                  30          

Ser Val Leu Ala Ser Ser Ser Val Asp Ala Gln Glu Thr Ala Gly Val 
        35                  40                  45              

His Tyr Lys Tyr Val Ala Asp Ser Glu Leu Ser Ser Glu Glu Lys Lys 
    50                  55                  60                  

Gln Leu Val Tyr Asp Ile Pro Thr Tyr Val Glu Asn Asp Asp Glu Thr 
65                  70                  75                  80  

Tyr Tyr Leu Val Tyr Lys Leu Asn Ser Gln Asn Gln Leu Ala Glu Leu 
                85                  90                  95      

Pro Asn Thr Gly Ser Lys Asn Glu Arg Gln Ala Leu Val Ala Gly Ala 
            100                 105                 110         

Ser Leu Ala Ala Met Gly Ile Leu Ile Phe Ala Val Ser Lys Lys Lys 
        115                 120                 125             

Val Lys Asn Lys Thr Val Leu His Leu Val Leu Val Ala Gly Ile Gly 
    130                 135                 140                 

Asn Gly Val Leu Val Ser Val His Ala Leu Glu Asn His Leu Leu Leu 
145                 150                 155                 160 

Asn Tyr Asn Thr Asp Tyr Glu Leu Thr Ser Gly Glu Lys Leu Pro Leu 
                165                 170                 175     

Pro Lys Glu Ile Ser Gly Tyr Thr Tyr Ile Gly Tyr Ile Lys Glu Gly 
            180                 185                 190         

Lys Thr Thr Ser Glu Ser Glu Val Ser Asn Gln Lys Ser Ser Val Ala 
        195                 200                 205             

Thr Pro Thr Lys Gln Gln Lys Val Asp Tyr Asn Val Thr Pro Asn Phe 
    210                 215                 220                 

Val Asp His Pro Ser Thr Val Gln Ala Ile Gln Glu Gln Thr Pro Val 
225                 230                 235                 240 

Ser Ser Thr Lys Pro Thr Glu Val Gln Val Val Glu Lys Pro Phe Ser 
                245                 250                 255     

Thr Glu Leu Ile Asn Pro Arg Lys Glu Glu Lys Gln Ser Ser Asp Ser 
            260                 265                 270         

Gln Glu Gln Leu Ala Glu His Lys Asn Leu Glu Thr Lys Lys Glu Glu 
        275                 280                 285             

Lys Ile Ser Pro Lys Glu Lys Thr Gly Val Asn Thr Leu Asn Pro Gln 
    290                 295                 300                 

Asp Glu Val Leu Ser Gly Gln Leu Asn Lys Pro Glu Leu Leu Tyr Arg 
305                 310                 315                 320 

Glu Glu Thr Met Glu Thr Lys Ile Asp Phe Gln Glu Glu Ile Gln Glu 
                325                 330                 335     

Asn Pro Asp Leu Ala Glu Gly Thr Val Arg Val Lys Gln Glu Gly Lys 
            340                 345                 350         

Leu Gly Lys Lys Val Glu Ile Val Arg Ile Phe Ser Val Asn Lys Glu 
        355                 360                 365             

Glu Val Ser Arg Glu Ile Val Ser Thr Ser Thr Thr Ala Pro Ser Pro 
    370                 375                 380                 

Arg Ile Val Glu Lys Gly Thr Lys Lys Thr Gln Val Ile Lys Glu Gln 
385                 390                 395                 400 

Pro Glu Thr Gly Val Glu His Lys Asp Val Gln Ser Gly Ala Ile Val 
                405                 410                 415     

Glu Pro Ala Ile Gln Pro Glu Leu Pro Glu Ala Val Val Ser Asp Lys 
            420                 425                 430         

Gly Glu Pro Glu Val Gln Pro Thr Leu Pro Glu Ala Val Val Thr Asp 
        435                 440                 445             

Lys Gly Glu Thr Glu Val Gln Pro Glu Ser Pro Asp Thr Val Val Ser 
    450                 455                 460                 

Asp Lys Gly Glu Pro Glu Gln Val Ala Pro Leu Pro Glu Tyr Lys Gly 
465                 470                 475                 480 

Asn Ile Glu Gln Val Lys Pro Glu Thr Pro Val Glu Lys Thr Lys Glu 
                485                 490                 495     

Gln Gly Pro Glu Lys Thr Glu Glu Val Pro Val Lys Pro Thr Glu Glu 
            500                 505                 510         

Thr Pro Val Asn Pro Asn Glu Gly Thr Thr Glu Gly Thr Ser Ile Gln 
        515                 520                 525             

Glu Ala Glu Asn Pro Val Gln Pro Ala Glu Glu Ser Thr Thr Asn Ser 
    530                 535                 540                 

Glu Lys Val Ser Pro Asp Thr Ser Ser Lys Asn Thr Gly Glu Val Ser 
545                 550                 555                 560 

Ser Asn Pro Ser Asp Ser Thr Thr Ser Val Gly Glu Ser Asn Lys Pro 
                565                 570                 575     

Glu His Asn Asp Ser Lys Asn Glu Asn Ser Glu Lys Thr Val Glu Glu 
            580                 585                 590         

Val Pro Val Asn Pro Asn Glu Gly Thr Val Glu Gly Thr Ser Asn Gln 
        595                 600                 605             

Glu Thr Glu Lys Pro Val Gln Pro Ala Glu Glu Thr Gln Thr Asn Ser 
    610                 615                 620                 

Gly Lys Ile Ala Asn Glu Asn Thr Gly Glu Val Ser Asn Lys Pro Ser 
625                 630                 635                 640 

Asp Ser Lys Pro Pro Val Glu Glu Ser Asn Gln Pro Glu Lys Asn Gly 
                645                 650                 655     

Thr Ala Thr Lys Pro Glu Asn Ser Gly Asn Thr Thr Ser Glu Asn Gly 
            660                 665                 670         

Gln Thr Glu Pro Glu Pro Ser Asn Gly Asn Ser Thr Glu Asp Val Ser 
        675                 680                 685             

Thr Glu Ser Asn Thr Ser Asn Ser Asn Gly Asn Glu Glu Ile Lys Gln 
    690                 695                 700                 

Glu Asn Glu Leu Asp Pro Asp Lys Lys Val Glu Glu Pro Glu Lys Thr 
705                 710                 715                 720 

Leu Glu Leu Arg Asn Val Ser Asp Leu Glu Leu Tyr Ser Leu Ser Asn 
                725                 730                 735     

Gly Thr Tyr Lys Gln His Ile Ser Leu Glu Gln Val Pro Ser Asn Pro 
            740                 745                 750         

Asn Ser Tyr Phe Val Lys Val Lys Ser Ser Ser Phe Lys Asp Val Tyr 
        755                 760                 765             

Leu Pro Val Ala Ser Ile Ser Glu Glu Arg Lys Asn Asp Lys Ile Leu 
    770                 775                 780                 

Tyr Lys Ile Thr Ala Lys Val Glu Lys Leu Gln Gln Glu Ile Glu Ser 
785                 790                 795                 800 

Arg Tyr Lys Asp Asn Phe Thr Phe Tyr Leu Ala Lys Lys Gly Thr Glu 
                805                 810                 815     

Glu Thr Thr Asn Phe Thr Ser Phe Ser Asn Leu Val Lys Ala Ile Asn 
            820                 825                 830         

Gln Asn Pro Ser Gly Thr Tyr His Leu Ala Ala Ser Leu Asn Ala Asn 
        835                 840                 845             

Glu Val Glu Leu Gly Pro Asp Glu Arg Ser Tyr Ile Lys Asp Thr Phe 
    850                 855                 860                 

Thr Gly Arg Leu Ile Gly Glu Lys Asp Gly Lys Asn Tyr Ala Ile Tyr 
865                 870                 875                 880 

Asn Leu Lys Lys Pro Leu Phe Glu Asn Leu Ser Gly Ala Thr Val Glu 
                885                 890                 895     

Lys Leu Ser Leu Lys Asn Val Ala Ile Ser Gly Lys Asp Asp Ile Gly 
            900                 905                 910         

Ser Leu Ala Asn Glu Ala Gln Asn Asn Thr Lys Ile Lys Gln Val His 
        915                 920                 925             

Val Asp Gly Val Leu Ala Gly Glu Arg Gly Ile Gly Gly Leu Leu Ala 
    930                 935                 940                 

Lys Ala Glu Gln Ser Ser Ile Thr Glu Ser Ser Phe Lys Gly Arg Ile 
945                 950                 955                 960 

Ile Asn Thr Tyr Glu Thr Thr Ala Ala Tyr Asn Ile Gly Gly Met Val 
                965                 970                 975     

Gly His Leu Thr Gly Asp Lys Ala Leu Leu Thr Lys Ser Lys Ala Thr 
            980                 985                 990         

Val Ala Ile Ser Ser Asn Thr Asn Thr Ser Asp Gln Thr Val Gly Gly 
        995                 1000                1005            

Leu Ala Gly Leu Val Asp Arg Asp Ala Gln Ile Gln Asp Ser Tyr Ala 
    1010                1015                1020                

Glu Gly Asp Ile Asn Asn Val Lys His Phe Gly Arg Val Ala Gly Val 
1025                1030                1035                1040

Ala Gly Asn Leu Trp Asp Arg Thr Ser Gly Asp Val Arg His Ala Gly 
                1045                1050                1055    

Ser Leu Thr Asn Val Leu Ser Asp Val Asn Val Thr Asn Gly Asn Ala 
            1060                1065                1070        

Ile Thr Gly Tyr His Tyr Asn Glu Met Lys Val Lys Asp Thr Phe Ser 
        1075                1080                1085            

Ser Lys Ala Asn Arg Val Tyr Asn Val Thr Leu Val Lys Asp Glu Val 
    1090                1095                1100                

Val Ser Lys Glu Ser Phe Glu Glu Arg Gly Thr Met Leu Asp Ala Ser 
1105                1110                1115                1120

Gln Ile Ala Ser Lys Lys Ala Glu Ile Asn Pro Leu Ile Leu Pro Thr 
                1125                1130                1135    

Val Glu Pro Leu Ser Thr Ser Gly Lys Lys Asp Ser Asp Phe Ser Lys 
            1140                1145                1150        

Val Ala Tyr Tyr Gln Ala Lys Arg Asn Leu Thr Tyr Lys Asn Ile Glu 
        1155                1160                1165            

Lys Leu Leu Pro Phe Tyr Asn Lys Ala Thr Ile Val Lys Tyr Gly Asn 
    1170                1175                1180                

Leu Val Asn Glu Asn Ser Leu Leu Tyr Gln Lys Glu Leu Leu Ser Ala 
1185                1190                1195                1200

Val Met Met Lys Asp Asn Gln Val Ile Thr Asp Ile Val Ser Asn Lys 
                1205                1210                1215    

Gln Thr Ala Asn Lys Leu Leu Leu His Tyr Lys Asp Asp Leu Ser Glu 
            1220                1225                1230        

Lys Leu Asp Leu Lys Tyr Gln Asn Asp Phe Ala Lys Leu Ala Glu Tyr 
        1235                1240                1245            

Ser Leu Gly Asn Thr Gly Leu Leu Tyr Thr Pro Asn Gln Phe Leu Tyr 
    1250                1255                1260                

Asp Gln Thr Ser Ile Ile Lys Gln Val Leu Pro Asp Leu Gln Lys Val 
1265                1270                1275                1280

Asp Tyr His Ser Glu Ala Ile Arg Lys Thr Leu Gly Ile Ser Pro Asn 
                1285                1290                1295    

Val Lys Gln Thr Glu Leu Tyr Leu Glu Asp Gln Phe Ala Lys Thr Lys 
            1300                1305                1310        

Gln Gln Leu Glu Asp Ser Leu Lys Lys Leu Leu Ser Ala Asp Ala Gly 
        1315                1320                1325            

Leu Ala Ser Ala Asn Pro Val Thr Glu Gly Tyr Leu Val Asp Lys Ile 
    1330                1335                1340                

Lys Arg Asn Lys Glu Ala Leu Leu Leu Gly Leu Thr Tyr Leu Glu Arg 
1345                1350                1355                1360

Trp Tyr Asn Phe Ser Tyr Gly Gln Val Asn Val Lys Asp Leu Val Leu 
                1365                1370                1375    

Tyr His Leu Asp Phe Phe Gly Lys Gly Asn Ala Ser Pro Leu Asp Thr 
            1380                1385                1390        

Leu Ile Glu Leu Gly Lys Ser Gly Phe Asn Asn Leu Leu Ala Lys Asn 
        1395                1400                1405            

Asn Val Asp Thr Tyr Gly Ile Ser Leu Ala Ser Gln His Gly Thr Thr 
    1410                1415                1420                

Asp Leu Phe Ser Thr Leu Glu His Tyr Arg Lys Val Phe Leu Pro Asn 
1425                1430                1435                1440

Thr Ser Asn Asn Asp Trp Phe Lys Ser Glu Thr Lys Ala Tyr Ile Val 
                1445                1450                1455    

Glu Glu Lys Ser Thr Ile Glu Glu Val Lys Thr Lys Gln Gly Leu Ala 
            1460                1465                1470        

Gly Thr Lys Tyr Ser Ile Gly Val Tyr Asp Arg Ile Thr Ser Ala Thr 
        1475                1480                1485            

Trp Lys Tyr Arg Asn Met Val Leu Pro Leu Leu Thr Leu Pro Glu Arg 
    1490                1495                1500                

Ser Val Phe Val Ile Ser Thr Met Ser Ser Leu Gly Phe Gly Ala Tyr 
1505                1510                1515                1520

Asp Arg Tyr Arg Ser Ser Asp His Lys Ala Gly Lys Ala Leu Asn Asp 
                1525                1530                1535    

Phe Val Glu Glu Asn Ala Arg Glu Thr Ala Lys Arg Gln Arg Asp His 
            1540                1545                1550        

Tyr Asp Tyr Trp Tyr Arg Ile Leu Asp Asp Asn Ala Arg Glu Lys Leu 
        1555                1560                1565            

Tyr Arg Asn Ile Leu Leu Tyr Asp Ala Tyr Lys Phe Gly Asp Asp Asn 
    1570                1575                1580                

Thr Val Gly Lys Ala Thr Glu Val Ala Asp Phe Asp Asn Pro Asn Pro 
1585                1590                1595                1600

Ala Met Gln His Phe Phe Gly Pro Val Gly Asn Lys Val Gly His Asn 
                1605                1610                1615    

Gln His Gly Ala Tyr Ala Thr Gly Asp Ala Val Tyr Tyr Met Gly Tyr 
            1620                1625                1630        

Arg Met Leu Asp Lys Asp Gly Ala Ile Thr Tyr Thr His Glu Met Thr 
        1635                1640                1645            

His Asp Ser Asp Gln Asp Ile Tyr Leu Gly Gly Tyr Gly Arg Arg Ser 
    1650                1655                1660                

Gly Leu Gly Pro Glu Phe Phe Ala Lys Gly Leu Leu Gln Ala Pro Asp 
1665                1670                1675                1680

His Pro Asp Asp Ala Thr Ile Thr Ile Asn Ser Ile Leu Lys His Ser 
                1685                1690                1695    

Lys Ser Asp Ser Thr Glu Ser Arg Arg Leu Gln Val Leu Asp Pro Thr 
            1700                1705                1710        

Thr Arg Phe Asn Asn Ala Asp Asp Leu Lys Gln Tyr Val His Asn Met 
        1715                1720                1725            

Phe Asp Val Val Tyr Met Leu Glu Tyr Leu Glu Gly Asn Ser Ile Leu 
    1730                1735                1740                

Lys Leu Asp Thr Asn Gln Lys Gln Gln Leu Leu Arg Lys Val Thr Asn 
1745                1750                1755                1760

Glu Tyr His Pro Asp Pro Asp Gly Asn Lys Val Tyr Ala Thr Asn Val 
                1765                1770                1775    

Val Arg Asn Leu Thr Val Glu Glu Val Glu Arg Leu Arg Ser Phe Asn 
            1780                1785                1790        

Asp Leu Ile Asp Asn Asn Ile Leu Ser Ser Arg Glu Tyr Ala Ser Gly 
        1795                1800                1805            

Lys Tyr Glu Arg Asn Gly Tyr Phe Thr Ile Lys Leu Phe Ala Pro Ile 
    1810                1815                1820                

Tyr Ala Ala Leu Ser Asn Asp Ile Gly Thr Pro Gly Asp Leu Met Gly 
1825                1830                1835                1840

Arg Arg Ile Ala Tyr Glu Leu Leu Ala Ala Lys Gly Phe Lys Asp Gly 
                1845                1850                1855    

Met Val Pro Tyr Ile Ser Asn Gln Tyr Glu Glu Glu Ala Lys Gln Lys 
            1860                1865                1870        

Gly Lys Thr Ile Asn Leu Tyr Gly Lys Thr Arg Gly Leu Val Thr Asp 
        1875                1880                1885            

Asp Leu Val Leu Glu Lys Val Phe Asn Asn Gln Tyr His Thr Trp Ser 
    1890                1895                1900                

Glu Phe Lys Lys Ala Met Tyr Gln Glu Arg Gln Asp Gln Phe Asp Arg 
1905                1910                1915                1920

Leu Asn Lys Val Thr Phe Asn Asp Thr Thr Gln Pro Trp Gln Thr Phe 
                1925                1930                1935    

Ala Lys Lys Thr Thr Ser Ser Val Asp Glu Leu Gln Lys Leu Met Asp 
            1940                1945                1950        

Val Ala Val Arg Lys Asp Ala Glu His Asn Tyr Tyr His Trp Asn Asn 
        1955                1960                1965            

Tyr Asn Pro Asp Ile Asp Ser Glu Val His Lys Leu Lys Arg Ala Ile 
    1970                1975                1980                

Phe Lys Ala Tyr Leu Asp Gln Thr Asn Asp Phe Arg Ser Ser Ile Phe 
1985                1990                1995                2000

Glu Asn Lys Lys 
                

<210>   78
<211>   1084
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   78
Met Pro Val Glu Ile Lys Thr Thr Lys Glu Ile His Pro Lys Ile Tyr 
1               5                   10                  15      

Ala Tyr Thr Thr Pro Thr Val Thr Ser Asn Glu Gly Trp Ile Lys Ile 
            20                  25                  30          

Gly Tyr Thr Glu Arg Asp Val Thr Gln Arg Ile Lys Glu Gln Thr His 
        35                  40                  45              

Thr Ala His Ile Ala Thr Asp Val Leu Trp Thr Gly Asp Ala Ala Tyr 
    50                  55                  60                  

Thr Glu Glu Pro Asp Lys Gly Lys Thr Phe Lys Asp His Asp Phe His 
65                  70                  75                  80  

His Phe Leu Ser Phe His Asp Val Glu Arg Arg Pro Lys Thr Glu Trp 
                85                  90                  95      

Phe Tyr Phe Asn Gly Thr Pro Glu Lys Ser Lys Asn Leu Phe Asp Lys 
            100                 105                 110         

Phe Val Gln His Asp Leu Ser Gly Tyr Gln Pro Gly Lys Gly Gln Asp 
        115                 120                 125             

Tyr Thr Leu Arg Gln Glu Gln Glu Glu Ala Val Ala Lys Thr Leu Ala 
    130                 135                 140                 

Tyr Phe Gln Glu His Ala Gly Gly Lys Phe Leu Trp Asn Ala Lys Pro 
145                 150                 155                 160 

Arg Phe Gly Lys Thr Leu Ser Thr Tyr Asp Leu Ala Arg Arg Met Glu 
                165                 170                 175     

Ala Val Asn Val Leu Ile Val Thr Asn Arg Pro Ala Ile Ala Asn Ser 
            180                 185                 190         

Trp Tyr Asp Asp Phe Glu Thr Phe Ile Ala Gly Gln Thr Thr Tyr Lys 
        195                 200                 205             

Phe Val Ser Glu Ser Asp Ser Leu Lys Ser Arg Pro Ile Leu Ser Arg 
    210                 215                 220                 

Gln Glu Phe Leu Gly Ile Leu Ala Asp Asp Val Arg Gln Leu Ala Phe 
225                 230                 235                 240 

Ile Ser Leu Gln Asp Leu Lys Gly Ser Val Tyr Leu Gly Gly Glu His 
                245                 250                 255     

Asp Lys Leu Lys Trp Val Thr Asp Leu His Trp Asp Leu Leu Val Ile 
            260                 265                 270         

Asp Glu Ala His Glu Gly Val Asp Thr Phe Lys Thr Asp Gln Ala Phe 
        275                 280                 285             

Asn Lys Ile Arg Arg Asn Phe Thr Leu His Leu Ser Gly Thr Ser Phe 
    290                 295                 300                 

Lys Ala Leu Ala Lys Gly Asp Phe Thr Glu Glu Gln Ile Tyr Asn Trp 
305                 310                 315                 320 

Ser Tyr Ala Asp Glu Gln Ala Ala Lys Tyr Ser Trp Ser Leu Glu Gln 
                325                 330                 335     

Glu Glu Glu Asn Pro Tyr Glu Ser Leu Pro Gln Leu Asn Leu Phe Thr 
            340                 345                 350         

Tyr Gln Met Ser Gln Met Ile Gly Glu Lys Leu Glu Lys Gly Ala Gln 
        355                 360                 365             

Ile Asp Gly Glu Asn Ile Asp Tyr Val Phe Asp Leu Ser Glu Phe Phe 
    370                 375                 380                 

Ala Thr Asp Asp Lys Gly Lys Phe Ile His Glu His Asp Val Arg Asn 
385                 390                 395                 400 

Trp Leu Asp Thr Leu Ser Ser Asn Glu Lys Tyr Pro Phe Ser Thr Lys 
                405                 410                 415     

Glu Leu Arg Asn Glu Leu Lys His Thr Phe Trp Leu Leu Glu Arg Val 
            420                 425                 430         

Ala Ser Ala Lys Ala Leu Lys Ala Leu Leu Glu Glu His Pro Ile Tyr 
        435                 440                 445             

Glu Asn Tyr Glu Ile Val Leu Ala Ala Gly Asp Gly Arg Met Ser Glu 
    450                 455                 460                 

Glu Asp Asp Lys Val Lys Leu Lys Ser Leu Asp Leu Val Arg Lys Ala 
465                 470                 475                 480 

Ile Ala Glu Asn Asp Lys Thr Ile Thr Leu Ser Val Gly Gln Leu Thr 
                485                 490                 495     

Thr Gly Val Thr Ile Pro Glu Trp Thr Gly Val Leu Met Leu Ser Asn 
            500                 505                 510         

Leu Lys Ser Pro Ala Leu Tyr Met Gln Ala Ala Phe Arg Ala Gln Asn 
        515                 520                 525             

Pro Tyr Ser Trp Ser Asp Asn Lys Gly Asn His Phe Arg Lys Glu Arg 
    530                 535                 540                 

Ala Tyr Val Phe Asp Phe Ala Pro Glu Arg Thr Leu Ile Leu Phe Asp 
545                 550                 555                 560 

Glu Phe Ala Asn Asn Leu Leu Leu Val Thr Ala Ala Gly Arg Gly Thr 
                565                 570                 575     

Ser Ala Thr Arg Glu Glu Asn Ile Arg Glu Leu Leu Asn Phe Phe Pro 
            580                 585                 590         

Ile Ile Ala Glu Asp Arg Ala Gly Lys Met Val Glu Ile Asp Ala Lys 
        595                 600                 605             

Ala Val Leu Thr Thr Pro Arg Gln Ile Lys Ala Arg Glu Val Leu Lys 
    610                 615                 620                 

Arg Gly Phe Met Ser Asn Leu Leu Phe Asp Asn Ile Ser Gly Ile Phe 
625                 630                 635                 640 

Gln Ala Ser Gln Thr Val Leu Asp Ile Leu Asn Glu Leu Pro Val Glu 
                645                 650                 655     

Lys Glu Gly Lys Val Gln Asp Ser Ser Asp Leu Leu Asp Phe Ser Asp 
            660                 665                 670         

Val Thr Val Asp Asp Glu Gly Asn Ala Val Val Asp His Glu Ile Val 
        675                 680                 685             

Val Asn Gln Gln Met Arg Leu Phe Gly Glu Lys Val Tyr Gly Leu Gly 
    690                 695                 700                 

Glu Ser Val Ala Glu Leu Val Thr Lys Asp Glu Glu Arg Thr Gln Lys 
705                 710                 715                 720 

Gln Leu Val Asn Asp Leu Ser Lys Thr Val Ser Ser Val Ile Val Glu 
                725                 730                 735     

Glu Leu Lys Ala Asp Tyr Ser Leu Lys Thr Arg Glu Thr Glu Gln Ile 
            740                 745                 750         

Lys Lys Gln Ile Thr Ala Thr Leu Glu Asn Glu Ile Arg Lys Asn Asp 
        755                 760                 765             

Ile Glu Arg Lys Ile Ser Glu Ala His Ile Lys Gln Glu Leu Gln Gln 
    770                 775                 780                 

Gln Leu Lys Glu Ala Asn Asp Lys Ala Gln Lys Asp Lys Ile Gln Glu 
785                 790                 795                 800 

Asp Leu Glu Lys Arg Leu Glu Glu Asn Lys Leu Ile His Lys Glu Lys 
                805                 810                 815     

Leu Glu Gln Thr Leu Lys Lys Glu Val Glu Lys Met Pro Glu Lys Phe 
            820                 825                 830         

Ile Glu Gln Val Glu Ile Lys Arg Val Glu Gln Leu Lys Gln Ser Ala 
        835                 840                 845             

Gln Asp Glu Ile Arg Asp His Leu Arg Gly Phe Ala Arg Thr Ile Pro 
    850                 855                 860                 

Ser Phe Ile Met Ala Tyr Gly Asp Gln Thr Leu Thr Leu Asp Asn Phe 
865                 870                 875                 880 

Asp Ala Phe Val Pro Glu His Val Phe Tyr Glu Val Thr Gly Ile Thr 
                885                 890                 895     

Ile Asp Gln Phe Arg Tyr Leu Arg Asp Gly Gly Gln Asp Phe Ala Gly 
            900                 905                 910         

His Leu Phe Asp Lys Ala Thr Phe Asp Glu Ala Ile Gln Glu Phe Leu 
        915                 920                 925             

Arg Lys Lys Lys Glu Leu Ala Asp Tyr Phe Lys Asp Gln Lys Glu Asp 
    930                 935                 940                 

Ile Phe Asp Tyr Ile Pro Pro Gln Lys Thr Asn Gln Ile Phe Thr Pro 
945                 950                 955                 960 

Lys Arg Val Val Lys Arg Met Val Asp Asp Leu Glu Lys Glu Asn Pro 
                965                 970                 975     

Gly Ile Phe Asp Asp Pro Ser Lys Thr Phe Ile Asp Leu Tyr Met Lys 
            980                 985                 990         

Ser Gly Leu Tyr Ile Ala Glu Leu Val Lys Arg Leu Tyr Asn Ser Asn 
        995                 1000                1005            

Gly Leu Lys Glu Ala Phe Pro Asn Pro Glu Glu Arg Leu Lys His Ile 
    1010                1015                1020                

Leu Glu Lys Gln Val Tyr Gly Phe Ala Pro Ser Glu Ile Ile Tyr Asn 
1025                1030                1035                1040

Ile Ser Thr Asn Phe Ile Phe Gly Asn Leu Ser Lys Asp Ile Ser Arg 
                1045                1050                1055    

Lys Asn Phe Val Leu Ala Asp Thr Ile Pro Ala Ala Lys Glu Gly Ser 
            1060                1065                1070        

Ile Gln Lys Leu Val Asp Ser Tyr Phe Glu Asn Asn 
        1075                1080                

<210>   79
<211>   234
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   79
Met Lys Lys Ile Leu Ile Val Asp Asp Glu Lys Pro Ile Ser Asp Ile 
1               5                   10                  15      

Ile Lys Phe Asn Met Thr Lys Glu Gly Tyr Glu Val Val Thr Ala Phe 
            20                  25                  30          

Asn Gly Arg Glu Ala Leu Glu Gln Phe Glu Ala Glu Gln Pro Asp Ile 
        35                  40                  45              

Ile Ile Leu Asp Leu Met Leu Pro Glu Ile Asp Gly Leu Glu Val Ala 
    50                  55                  60                  

Lys Thr Ile Arg Lys Thr Ser Ser Val Pro Ile Leu Met Leu Ser Ala 
65                  70                  75                  80  

Lys Asp Ser Glu Phe Asp Lys Val Ile Gly Leu Glu Leu Gly Ala Asp 
                85                  90                  95      

Asp Tyr Val Thr Lys Pro Phe Ser Asn Arg Glu Leu Gln Ala Arg Val 
            100                 105                 110         

Lys Ala Leu Leu Arg Arg Ser Gln Pro Met Pro Val Asp Gly Gln Glu 
        115                 120                 125             

Ala Asp Ser Lys Pro Gln Pro Ile Gln Ile Gly Asp Leu Glu Ile Val 
    130                 135                 140                 

Pro Asp Ala Tyr Val Ala Lys Lys Tyr Gly Glu Glu Leu Asp Leu Thr 
145                 150                 155                 160 

His Arg Glu Phe Glu Leu Leu Tyr His Leu Ala Ser His Thr Gly Gln 
                165                 170                 175     

Val Ile Thr Arg Glu His Leu Leu Glu Thr Val Trp Gly Tyr Asp Tyr 
            180                 185                 190         

Phe Gly Asp Val Arg Thr Val Asp Val Thr Val Arg Arg Leu Arg Glu 
        195                 200                 205             

Lys Ile Glu Asp Thr Pro Ser Arg Pro Glu Tyr Ile Leu Thr Arg Arg 
    210                 215                 220                 

Gly Val Gly Tyr Tyr Met Arg Asn Asn Ala 
225                 230                 

<210>   80
<211>   721
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   80
Met Lys Lys Lys Phe Leu Ala Phe Leu Leu Ile Leu Phe Pro Ile Phe 
1               5                   10                  15      

Ser Leu Gly Ile Ala Lys Ala Glu Thr Ile Lys Ile Val Ser Asp Thr 
            20                  25                  30          

Ala Tyr Ala Pro Phe Glu Phe Lys Asp Ser Asp Gln Thr Tyr Lys Gly 
        35                  40                  45              

Ile Asp Val Asp Ile Ile Asn Lys Val Ala Glu Ile Lys Gly Trp Asn 
    50                  55                  60                  

Ile Gln Met Ser Tyr Pro Gly Phe Asp Ala Ala Val Asn Ala Val Gln 
65                  70                  75                  80  

Ala Gly Gln Ala Asp Ala Ile Met Ala Gly Met Thr Lys Thr Lys Glu 
                85                  90                  95      

Arg Glu Lys Val Phe Thr Met Ser Asp Thr Tyr Tyr Asp Thr Lys Val 
            100                 105                 110         

Val Ile Ala Thr Thr Lys Ser His Lys Ile Ser Lys Tyr Asp Gln Leu 
        115                 120                 125             

Thr Gly Lys Thr Val Gly Val Lys Asn Gly Thr Ala Ala Gln Arg Phe 
    130                 135                 140                 

Leu Glu Thr Ile Lys Asp Lys Tyr Gly Phe Thr Ile Lys Thr Phe Asp 
145                 150                 155                 160 

Thr Gly Asp Leu Met Asn Asn Ser Leu Ser Ala Gly Ala Ile Asp Ala 
                165                 170                 175     

Met Met Asp Asp Lys Pro Val Ile Glu Tyr Ala Ile Asn Gln Gly Gln 
            180                 185                 190         

Asp Leu His Ile Glu Met Asp Gly Glu Ala Val Gly Ser Phe Ala Phe 
        195                 200                 205             

Gly Val Lys Lys Gly Ser Lys Tyr Glu His Leu Val Thr Glu Phe Asn 
    210                 215                 220                 

Gln Ala Leu Ser Glu Met Lys Lys Asp Gly Ser Leu Asp Lys Ile Ile 
225                 230                 235                 240 

Lys Lys Trp Thr Ala Ser Ser Ser Ser Ala Val Pro Thr Thr Thr Thr 
                245                 250                 255     

Leu Ala Gly Leu Lys Ala Ile Pro Val Lys Ala Lys Tyr Ile Ile Ala 
            260                 265                 270         

Ser Asp Ser Ser Phe Ala Pro Phe Val Phe Gln Asn Ser Ser Asn Gln 
        275                 280                 285             

Tyr Thr Gly Ile Asp Met Glu Leu Ile Lys Ala Ile Ala Lys Asp Gln 
    290                 295                 300                 

Gly Phe Glu Ile Glu Ile Thr Asn Pro Gly Phe Asp Ala Ala Ile Ser 
305                 310                 315                 320 

Ala Val Gln Ala Gly Gln Ala Asp Gly Ile Ile Ala Gly Met Ser Val 
                325                 330                 335     

Thr Asp Ala Arg Lys Ala Thr Phe Asp Phe Ser Glu Ser Tyr Tyr Thr 
            340                 345                 350         

Ala Asn Thr Ile Leu Gly Val Lys Glu Ser Ser Asn Ile Ala Ser Tyr 
        355                 360                 365             

Glu Asp Leu Lys Gly Lys Thr Val Gly Val Lys Asn Gly Thr Ala Ser 
    370                 375                 380                 

Gln Thr Phe Leu Thr Glu Asn Gln Ser Lys Tyr Gly Tyr Lys Ile Lys 
385                 390                 395                 400 

Thr Phe Ala Asp Gly Ser Ser Met Tyr Asp Ser Leu Asn Thr Gly Ala 
                405                 410                 415     

Ile Asp Ala Val Met Asp Asp Glu Pro Val Leu Lys Tyr Ser Ile Ser 
            420                 425                 430         

Gln Gly Gln Lys Leu Lys Thr Pro Ile Ser Gly Thr Pro Ile Gly Glu 
        435                 440                 445             

Thr Ala Phe Ala Val Lys Lys Gly Ala Asn Pro Glu Leu Ile Glu Met 
    450                 455                 460                 

Phe Asn Asn Gly Leu Ala Asn Leu Lys Ala Asn Gly Glu Phe Gln Lys 
465                 470                 475                 480 

Ile Leu Asp Lys Tyr Leu Ala Ser Glu Ser Ser Thr Ala Ser Thr Ser 
                485                 490                 495     

Thr Val Asp Glu Thr Thr Leu Trp Gly Leu Leu Gln Asn Asn Tyr Lys 
            500                 505                 510         

Gln Leu Leu Ser Gly Leu Gly Ile Thr Leu Ala Leu Ala Leu Ile Ser 
        515                 520                 525             

Phe Ala Ile Ala Ile Val Ile Gly Ile Ile Phe Gly Met Phe Ser Val 
    530                 535                 540                 

Ser Pro Tyr Lys Ser Leu Arg Val Ile Ser Glu Ile Phe Val Asp Val 
545                 550                 555                 560 

Ile Arg Gly Ile Pro Leu Met Ile Leu Ala Ala Phe Ile Phe Trp Gly 
                565                 570                 575     

Ile Pro Asn Phe Ile Glu Ser Ile Thr Gly Gln Gln Ser Pro Ile Asn 
            580                 585                 590         

Asp Phe Val Ala Gly Thr Ile Ala Leu Ser Leu Asn Ala Ala Ala Tyr 
        595                 600                 605             

Ile Ala Glu Ile Val Arg Gly Gly Ile Gln Ala Val Pro Val Gly Gln 
    610                 615                 620                 

Met Glu Ala Ser Arg Ser Leu Gly Ile Ser Tyr Gly Lys Thr Met Arg 
625                 630                 635                 640 

Lys Ile Ile Leu Pro Gln Ala Thr Lys Leu Met Leu Pro Asn Phe Val 
                645                 650                 655     

Asn Gln Phe Val Ile Ala Leu Lys Asp Thr Thr Ile Val Ser Ala Ile 
            660                 665                 670         

Gly Leu Val Glu Leu Phe Gln Thr Gly Lys Ile Ile Ile Ala Arg Asn 
        675                 680                 685             

Tyr Gln Ser Phe Lys Met Tyr Ala Ile Leu Ala Ile Phe Tyr Leu Val 
    690                 695                 700                 

Ile Ile Thr Leu Leu Thr Arg Leu Ala Lys Arg Leu Glu Lys Arg Ile 
705                 710                 715                 720 

Arg 
    

<210>   81
<211>   523
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   81
Met Ala Phe Glu Ser Leu Thr Glu Arg Leu Gln Asn Val Phe Lys Asn 
1               5                   10                  15      

Leu Arg Lys Lys Gly Lys Ile Ser Glu Ser Asp Val Gln Glu Ala Thr 
            20                  25                  30          

Lys Glu Ile Arg Leu Ala Leu Leu Glu Ala Asp Val Ala Leu Pro Val 
        35                  40                  45              

Val Lys Asp Phe Ile Lys Lys Val Arg Glu Arg Ala Val Gly His Glu 
    50                  55                  60                  

Val Ile Asp Thr Leu Asn Pro Ala Gln Gln Ile Ile Lys Ile Val Asp 
65                  70                  75                  80  

Glu Glu Leu Thr Ala Val Leu Gly Ser Asp Thr Ala Glu Ile Ile Lys 
                85                  90                  95      

Ser Pro Lys Ile Pro Thr Ile Ile Met Met Val Gly Leu Gln Gly Ala 
            100                 105                 110         

Gly Lys Thr Thr Phe Ala Gly Lys Leu Ala Asn Lys Leu Lys Lys Glu 
        115                 120                 125             

Glu Asn Ala Arg Pro Leu Met Ile Ala Ala Asp Ile Tyr Arg Pro Ala 
    130                 135                 140                 

Ala Ile Asp Gln Leu Lys Thr Leu Gly Gln Gln Ile Asp Val Pro Val 
145                 150                 155                 160 

Phe Ala Leu Gly Thr Glu Val Pro Ala Val Glu Ile Val Arg Gln Gly 
                165                 170                 175     

Leu Glu Gln Ala Gln Thr Asn His Asn Asp Tyr Val Leu Ile Asp Thr 
            180                 185                 190         

Ala Gly Arg Leu Gln Ile Asp Glu Leu Leu Met Asn Glu Leu Arg Asp 
        195                 200                 205             

Val Lys Ala Leu Ala Gln Pro Asn Glu Ile Leu Leu Val Val Asp Ala 
    210                 215                 220                 

Met Ile Gly Gln Glu Ala Ala Asn Val Ala Arg Glu Phe Asn Ala Gln 
225                 230                 235                 240 

Leu Glu Val Thr Gly Val Ile Leu Thr Lys Ile Asp Gly Asp Thr Arg 
                245                 250                 255     

Gly Gly Ala Ala Leu Ser Val Arg His Ile Thr Gly Lys Pro Ile Lys 
            260                 265                 270         

Phe Thr Gly Thr Gly Glu Lys Ile Thr Asp Ile Glu Thr Phe His Pro 
        275                 280                 285             

Asp Arg Met Ser Ser Arg Ile Leu Gly Met Gly Asp Met Leu Thr Leu 
    290                 295                 300                 

Ile Glu Lys Ala Ser Gln Glu Tyr Asp Glu Gln Lys Ala Leu Glu Met 
305                 310                 315                 320 

Ala Glu Lys Met Arg Glu Asn Thr Phe Asp Phe Asn Asp Phe Ile Asp 
                325                 330                 335     

Gln Leu Asp Gln Val Gln Asn Met Gly Pro Met Glu Asp Leu Leu Lys 
            340                 345                 350         

Met Ile Pro Gly Met Ala Asn Asn Pro Ala Leu Gln Asn Met Lys Val 
        355                 360                 365             

Asp Glu Arg Gln Ile Ala Arg Lys Arg Ala Ile Val Ser Ser Met Thr 
    370                 375                 380                 

Pro Glu Glu Arg Glu Asn Pro Asp Leu Leu Asn Pro Ser Arg Arg Arg 
385                 390                 395                 400 

Arg Ile Ala Ala Gly Ser Gly Asn Thr Phe Val Glu Val Asn Lys Phe 
                405                 410                 415     

Ile Lys Asp Phe Asn Gln Ala Lys Gln Leu Met Gln Gly Val Met Ser 
            420                 425                 430         

Gly Asp Met Asn Lys Met Met Lys Gln Met Gly Ile Asn Pro Asn Asn 
        435                 440                 445             

Leu Pro Lys Asn Met Pro Asn Met Gly Gly Met Asp Met Ser Ala Leu 
    450                 455                 460                 

Glu Gly Met Met Gly Gln Gly Gly Met Pro Asp Leu Ser Ala Leu Gly 
465                 470                 475                 480 

Gly Ala Gly Met Pro Asp Met Ser Gln Met Phe Gly Gly Gly Leu Lys 
                485                 490                 495     

Gly Lys Ile Gly Glu Phe Ala Met Lys Gln Ser Met Lys Arg Met Ala 
            500                 505                 510         

Asn Lys Met Lys Lys Ala Lys Lys Lys Arg Lys 
        515                 520             

<210>   82
<211>   233
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   82
Met Ser Gln Ile Trp Thr Lys Glu Lys Phe Ile Ser Gln Val Gln Gly 
1               5                   10                  15      

Gly Val Ile Val Ser Cys Gln Ala Leu Pro Gly Glu Ala Leu Tyr Asn 
            20                  25                  30          

Glu Glu Phe Ser Leu Met Pro Phe Met Ala Lys Ala Ala Leu Glu Ala 
        35                  40                  45              

Gly Ala Val Gly Ile Arg Ala Asn Ser Val Arg Asp Ile Lys Ala Ile 
    50                  55                  60                  

Gln Lys Val Val Asp Leu Pro Ile Ile Gly Ile Ile Lys Arg Asp Tyr 
65                  70                  75                  80  

Pro Pro Gln Glu Pro Tyr Ile Thr Ala Thr Met Lys Glu Val Asp Glu 
                85                  90                  95      

Leu Val Glu Cys Gly Thr Thr Val Ile Ala Phe Asp Ala Thr Leu Arg 
            100                 105                 110         

Pro Arg Tyr Asp Gly Leu Val Val Ser Glu Phe Ile Lys Lys Ile Lys 
        115                 120                 125             

Glu Lys Tyr Pro Asn Gln Leu Leu Met Ala Asp Val Ser Asn Leu Asp 
    130                 135                 140                 

Glu Gly Leu Tyr Ala Phe Lys Ser Gly Val Asp Phe Val Gly Thr Thr 
145                 150                 155                 160 

Leu Ser Gly Tyr Thr Ser Thr Ser Val Gln Ser Asp Glu Pro Asp Phe 
                165                 170                 175     

Glu Leu Met Lys Lys Leu Ala Asp Phe Asn Ile Pro Val Ile Ala Glu 
            180                 185                 190         

Gly Lys Ile His Tyr Pro Glu Gln Leu Lys Lys Ala Tyr Ser Leu Gly 
        195                 200                 205             

Val Thr Ser Val Val Ile Gly Gly Ala Ile Thr Arg Pro Lys Glu Ile 
    210                 215                 220                 

Ala Gln Arg Phe Ile Asn Val Ile Lys 
225                 230             

<210>   83
<211>   388
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   83
Met Arg Tyr Leu Thr Ala Gly Glu Ser His Gly Pro Arg Leu Thr Ala 
1               5                   10                  15      

Ile Ile Glu Gly Ile Pro Ala Gly Leu Pro Leu Thr Ala Glu Asp Ile 
            20                  25                  30          

Asn Glu Asp Leu Arg Arg Arg Gln Gly Gly Tyr Gly Arg Gly Gly Arg 
        35                  40                  45              

Met Lys Ile Glu Asn Asp Gln Val Val Phe Thr Ser Gly Val Arg His 
    50                  55                  60                  

Gly Lys Thr Thr Gly Ala Pro Ile Thr Met Asp Val Ile Asn Lys Asp 
65                  70                  75                  80  

His Gln Lys Trp Leu Asp Ile Met Ser Ala Glu Asp Ile Glu Asp Arg 
                85                  90                  95      

Leu Lys Ser Lys Arg Lys Ile Thr His Pro Arg Pro Gly His Ala Asp 
            100                 105                 110         

Leu Val Gly Gly Ile Lys Tyr Arg Phe Asp Asp Leu Arg Asn Ser Leu 
        115                 120                 125             

Glu Arg Ser Ser Ala Arg Glu Thr Thr Met Arg Val Ala Val Gly Ala 
    130                 135                 140                 

Val Ala Lys Arg Leu Leu Ala Glu Leu Asp Met Glu Ile Ala Asn His 
145                 150                 155                 160 

Val Val Val Phe Gly Gly Lys Glu Ile Asp Val Pro Glu Asn Leu Thr 
                165                 170                 175     

Val Ala Glu Ile Lys Gln Arg Ala Ala Gln Ser Glu Val Ser Ile Val 
            180                 185                 190         

Asn Gln Glu Arg Glu Gln Glu Ile Lys Asp Tyr Ile Asp Gln Ile Lys 
        195                 200                 205             

Arg Asp Gly Asp Thr Ile Gly Gly Val Val Glu Thr Val Val Gly Gly 
    210                 215                 220                 

Val Pro Val Gly Leu Gly Ser Tyr Val Gln Trp Asp Arg Lys Leu Asp 
225                 230                 235                 240 

Ala Arg Leu Ala Gln Ala Val Val Ser Ile Asn Ala Phe Lys Gly Val 
                245                 250                 255     

Glu Phe Gly Leu Gly Phe Glu Ala Gly Tyr Arg Lys Gly Ser Gln Val 
            260                 265                 270         

Met Asp Glu Ile Leu Trp Ser Lys Glu Asp Gly Tyr Thr Arg Arg Thr 
        275                 280                 285             

Asn Asn Leu Gly Gly Phe Glu Gly Gly Met Thr Asn Gly Gln Pro Ile 
    290                 295                 300                 

Val Val Arg Gly Val Met Lys Pro Ile Pro Thr Leu Tyr Lys Pro Leu 
305                 310                 315                 320 

Met Ser Val Asp Ile Glu Thr His Glu Pro Tyr Lys Ala Thr Val Glu 
                325                 330                 335     

Arg Ser Asp Pro Thr Ala Leu Pro Ala Ala Gly Met Val Met Glu Ala 
            340                 345                 350         

Val Val Ala Thr Val Leu Ala Gln Glu Ile Leu Glu Lys Phe Ser Ser 
        355                 360                 365             

Asp Asn Leu Glu Glu Leu Lys Glu Ala Val Ala Lys His Arg Asp Tyr 
    370                 375                 380                 

Thr Lys Asn Tyr 
385             

<210>   84
<211>   390
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   84
Met Val Val Met Asn Arg Ile Arg Val Ser Lys Arg Val Glu Lys Lys 
1               5                   10                  15      

Leu Ala Lys Gly Leu Val Leu Leu Glu Ala Ser Asp Leu Glu Asn Val 
            20                  25                  30          

Asn Leu Lys Asp Gln Glu Val Glu Val Gln Gly Gln Glu Gly Asn Phe 
        35                  40                  45              

Leu Gly Thr Ala Tyr Leu Ser Gln Gln Asn Lys Gly Leu Gly Trp Phe 
    50                  55                  60                  

Ile Ser Lys Asp Lys Val Ala Phe Asn Gln Ala Phe Phe Glu Thr Leu 
65                  70                  75                  80  

Phe Arg Lys Ala Lys Glu Lys Arg Asn Ala Tyr Tyr Gln Asp Asp Leu 
                85                  90                  95      

Thr Thr Ala Phe Arg Leu Phe Asn Gln Glu Gly Asp Gly Phe Gly Gly 
            100                 105                 110         

Leu Thr Val Asp Leu Tyr Gly Asp Tyr Ala Val Phe Ser Trp Tyr Asn 
        115                 120                 125             

Ser Tyr Val Tyr Gln Ile Arg Gln Thr Ile Ser Glu Ala Phe Arg Gln 
    130                 135                 140                 

Val Phe Pro Glu Val Leu Gly Ala Tyr Glu Lys Ile Arg Phe Lys Gly 
145                 150                 155                 160 

Leu Asp Tyr Glu Ser Ala His Val Tyr Gly Gln Glu Ala Pro Asp Phe 
                165                 170                 175     

Phe Asn Val Leu Glu Asn Gly Val Leu Tyr Gln Val Phe Met Asn Asp 
            180                 185                 190         

Gly Leu Met Thr Gly Ile Phe Leu Asp Gln His Glu Val Arg Gly Ser 
        195                 200                 205             

Leu Val Asp Gly Leu Ala Met Gly Lys Ser Leu Leu Asn Met Phe Ser 
    210                 215                 220                 

Tyr Thr Ala Ala Phe Ser Val Ala Ala Ala Met Gly Gly Ala Ser His 
225                 230                 235                 240 

Thr Thr Ser Val Asp Leu Ala Lys Arg Ser Arg Glu Leu Ser Gln Ala 
                245                 250                 255     

His Phe Gln Ala Asn Gly Leu Ser Thr Asp Glu His Arg Phe Ile Val 
            260                 265                 270         

Met Asp Val Phe Glu Tyr Phe Lys Tyr Ala Lys Arg Lys Asp Leu Thr 
        275                 280                 285             

Tyr Asp Val Ile Val Leu Asp Pro Pro Ser Phe Ala Arg Asn Lys Lys 
    290                 295                 300                 

Gln Thr Phe Ser Val Ala Lys Asp Tyr His Lys Leu Ile Ser Gln Ser 
305                 310                 315                 320 

Leu Glu Ile Leu Asn Pro Gly Gly Ile Ile Ile Ala Ser Thr Asn Ala 
                325                 330                 335     

Ala Asn Val Ser Arg Gln Lys Phe Thr Glu Gln Ile Asp Lys Gly Phe 
            340                 345                 350         

Ala Gly Arg Ser Tyr Gln Ile Leu Asn Lys Tyr Gly Leu Pro Ala Asp 
        355                 360                 365             

Phe Ala Tyr Asn Lys Lys Asp Glu Ser Ser Asn Tyr Leu Lys Val Ile 
    370                 375                 380                 

Ser Met Lys Val Ser Lys 
385                 390 

<210>   85
<211>   428
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   85
Met Thr Lys Thr Leu Lys Arg Pro Glu Val Leu Ser Pro Ala Gly Thr 
1               5                   10                  15      

Leu Glu Lys Leu Lys Val Ala Val Gln Tyr Gly Ala Asp Ala Val Phe 
            20                  25                  30          

Ile Gly Gly Gln Ala Tyr Gly Leu Arg Ser Arg Ala Gly Asn Phe Thr 
        35                  40                  45              

Phe Glu Gln Met Glu Glu Gly Val Gln Phe Ala Ala Lys Tyr Gly Ala 
    50                  55                  60                  

Lys Val Tyr Val Ala Ala Asn Met Val Met His Glu Gly Asn Glu Ala 
65                  70                  75                  80  

Gly Ala Gly Glu Trp Phe Arg Lys Leu Arg Asp Ile Gly Ile Ala Ala 
                85                  90                  95      

Val Ile Val Ser Asp Pro Ala Leu Ile Met Ile Ala Val Thr Glu Ala 
            100                 105                 110         

Pro Gly Leu Glu Ile His Leu Ser Thr Gln Ala Ser Ala Thr Asn Tyr 
        115                 120                 125             

Glu Thr Leu Glu Phe Trp Lys Glu Leu Gly Leu Thr Arg Val Val Leu 
    130                 135                 140                 

Ala Arg Glu Val Ser Met Glu Glu Leu Ala Glu Ile Arg Lys Arg Thr 
145                 150                 155                 160 

Asp Val Glu Ile Glu Ala Phe Val His Gly Ala Met Cys Ile Ser Tyr 
                165                 170                 175     

Ser Gly Arg Cys Thr Leu Ser Asn His Met Ser Met Arg Asp Ala Asn 
            180                 185                 190         

Arg Gly Gly Cys Ser Gln Ser Cys Arg Trp Lys Tyr Asp Leu Tyr Asp 
        195                 200                 205             

Met Pro Phe Gly Lys Glu Arg Lys Ser Leu Gln Gly Glu Ile Pro Glu 
    210                 215                 220                 

Glu Phe Ser Met Ser Ala Val Asp Met Ser Met Ile Asp His Ile Pro 
225                 230                 235                 240 

Asp Met Ile Glu Asn Gly Val Asp Ser Leu Lys Ile Glu Gly Arg Met 
                245                 250                 255     

Lys Ser Ile His Tyr Val Ser Thr Val Thr Asn Cys Tyr Lys Ala Ala 
            260                 265                 270         

Val Asp Ala Tyr Leu Glu Ser Pro Glu Lys Phe Glu Ala Ile Lys Gln 
        275                 280                 285             

Asp Leu Val Asp Glu Met Trp Lys Val Ala Gln Arg Glu Leu Ala Thr 
    290                 295                 300                 

Gly Phe Tyr Tyr Gly Thr Pro Ser Glu Asn Glu Gln Leu Phe Gly Ala 
305                 310                 315                 320 

Arg Arg Lys Ile Pro Glu Tyr Lys Phe Val Ala Glu Val Val Ser Tyr 
                325                 330                 335     

Asp Asp Ala Ala Gln Thr Ala Thr Ile Arg Gln Arg Asn Val Ile Asn 
            340                 345                 350         

Glu Gly Asp Gln Val Glu Phe Tyr Gly Pro Gly Phe Arg His Phe Glu 
        355                 360                 365             

Thr Tyr Ile Glu Asp Leu His Asp Ala Lys Gly Asn Lys Ile Asp Arg 
    370                 375                 380                 

Ala Pro Asn Pro Met Glu Leu Leu Thr Ile Lys Val Pro Gln Pro Val 
385                 390                 395                 400 

Gln Ser Gly Asp Met Val Arg Ala Leu Lys Glu Gly Leu Ile Asn Leu 
                405                 410                 415     

Tyr Lys Glu Asp Gly Thr Ser Val Thr Val Arg Ala 
            420                 425             

<210>   86
<211>   280
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   86
Met Asn Thr Tyr Gln Leu Asn Asn Gly Val Glu Ile Pro Val Leu Gly 
1               5                   10                  15      

Phe Gly Thr Phe Lys Ala Lys Asp Gly Glu Glu Ala Tyr Arg Ala Val 
            20                  25                  30          

Leu Glu Ala Leu Lys Ala Gly Tyr Arg His Ile Asp Thr Ala Ala Ile 
        35                  40                  45              

Tyr Gln Asn Glu Glu Ser Val Gly Gln Ala Ile Lys Asp Ser Gly Val 
    50                  55                  60                  

Pro Arg Glu Glu Met Phe Val Thr Thr Lys Leu Trp Asn Ser Gln Gln 
65                  70                  75                  80  

Thr Tyr Glu Gln Thr Arg Gln Ala Leu Glu Lys Ser Ile Glu Lys Leu 
                85                  90                  95      

Gly Leu Asp Tyr Leu Asp Leu Tyr Leu Ile His Trp Pro Asn Pro Lys 
            100                 105                 110         

Pro Leu Arg Glu Asn Asp Ala Trp Lys Thr Arg Asn Ala Glu Val Trp 
        115                 120                 125             

Arg Ala Met Glu Asp Leu Tyr Gln Glu Gly Lys Ile Arg Ala Ile Gly 
    130                 135                 140                 

Val Ser Asn Phe Leu Pro His His Leu Asp Ala Leu Leu Glu Thr Ala 
145                 150                 155                 160 

Thr Ile Val Pro Ala Val Asn Gln Val Arg Leu Ala Pro Gly Val Tyr 
                165                 170                 175     

Gln Asp Gln Val Val Ala Tyr Cys Arg Glu Lys Gly Ile Leu Leu Glu 
            180                 185                 190         

Ala Trp Gly Pro Phe Gly Gln Gly Glu Leu Phe Asp Ser Lys Gln Val 
        195                 200                 205             

Gln Glu Ile Ala Ala Asn His Gly Lys Ser Val Ala Gln Ile Ala Leu 
    210                 215                 220                 

Ala Trp Ser Leu Ala Glu Gly Phe Leu Pro Leu Pro Lys Ser Val Thr 
225                 230                 235                 240 

Thr Ser Arg Ile Gln Ala Asn Leu Asp Cys Phe Gly Ile Glu Leu Ser 
                245                 250                 255     

His Glu Glu Arg Glu Thr Leu Lys Thr Ile Ala Val Gln Ser Gly Ala 
            260                 265                 270         

Pro Arg Val Asp Asp Val Asp Phe 
        275                 280 

<210>   87
<211>   551
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   87
Leu Ser Glu Lys Ser Arg Glu Glu Glu Lys Leu Ser Phe Lys Glu Gln 
1               5                   10                  15      

Ile Leu Arg Asp Leu Glu Lys Val Lys Gly Tyr Asp Glu Val Leu Lys 
            20                  25                  30          

Glu Asp Glu Ala Val Val Arg Thr Pro Ala Asn Glu Pro Ser Thr Glu 
        35                  40                  45              

Glu Leu Met Ala Asp Ser Leu Ser Thr Val Glu Glu Ile Met Arg Lys 
    50                  55                  60                  

Ala Pro Thr Val Pro Thr His Pro Ser Gln Gly Val Pro Ala Ser Pro 
65                  70                  75                  80  

Ala Asp Glu Ile Gln Arg Glu Thr Pro Gly Val Pro Ser His Pro Ser 
                85                  90                  95      

Gln Asp Val Pro Ser Ser Pro Ala Glu Glu Ser Gly Ser Arg Pro Gly 
            100                 105                 110         

Pro Gly Pro Val Arg Pro Lys Lys Leu Glu Arg Glu Tyr Asn Glu Thr 
        115                 120                 125             

Pro Thr Arg Val Ala Val Ser Tyr Thr Thr Ala Glu Lys Lys Ala Glu 
    130                 135                 140                 

Gln Ala Gly Pro Glu Thr Pro Thr Pro Ala Thr Glu Thr Val Asp Ile 
145                 150                 155                 160 

Ile Arg Asp Thr Ser Arg Arg Ser Arg Arg Glu Gly Ala Lys Pro Val 
                165                 170                 175     

Lys Pro Lys Lys Glu Lys Lys Ser His Val Lys Ala Phe Val Ile Ser 
            180                 185                 190         

Phe Leu Val Phe Leu Ala Leu Leu Ser Ala Gly Gly Tyr Phe Gly Tyr 
        195                 200                 205             

Gln Tyr Val Leu Asp Ser Leu Leu Pro Ile Asp Ala Asn Ser Lys Lys 
    210                 215                 220                 

Tyr Val Thr Val Gly Ile Pro Glu Gly Ser Asn Val Gln Glu Ile Gly 
225                 230                 235                 240 

Thr Thr Leu Glu Lys Ala Gly Leu Val Lys His Gly Leu Ile Phe Ser 
                245                 250                 255     

Phe Tyr Ala Lys Tyr Lys Asn Tyr Thr Asp Leu Lys Ala Gly Tyr Tyr 
            260                 265                 270         

Asn Leu Gln Lys Ser Met Ser Thr Glu Asp Leu Leu Lys Glu Leu Gln 
        275                 280                 285             

Lys Gly Gly Thr Asp Glu Pro Gln Glu Pro Val Leu Ala Thr Leu Thr 
    290                 295                 300                 

Ile Pro Glu Gly Tyr Thr Leu Asp Gln Ile Ala Gln Ala Val Gly Gln 
305                 310                 315                 320 

Leu Gln Gly Asp Phe Lys Glu Ser Leu Thr Ala Glu Ala Phe Leu Ala 
                325                 330                 335     

Lys Val Gln Asp Glu Thr Phe Ile Ser Gln Ala Val Ala Lys Tyr Pro 
            340                 345                 350         

Thr Leu Leu Glu Ser Leu Pro Val Lys Asp Ser Gly Ala Arg Tyr Arg 
        355                 360                 365             

Leu Glu Gly Tyr Leu Phe Pro Ala Thr Tyr Ser Ile Lys Glu Ser Thr 
    370                 375                 380                 

Thr Ile Glu Ser Leu Ile Asp Glu Met Leu Ala Ala Met Asp Lys Asn 
385                 390                 395                 400 

Leu Ser Pro Tyr Tyr Ser Thr Ile Lys Ser Lys Asn Leu Thr Val Asn 
                405                 410                 415     

Glu Leu Leu Thr Ile Ala Ser Leu Val Glu Lys Glu Gly Ala Lys Thr 
            420                 425                 430         

Glu Asp Arg Lys Leu Ile Ala Gly Val Phe Tyr Asn Arg Leu Asn Arg 
        435                 440                 445             

Asp Met Pro Leu Gln Ser Asn Ile Ala Ile Leu Tyr Ala Gln Gly Lys 
    450                 455                 460                 

Leu Gly Gln Asn Ile Ser Leu Ala Glu Asp Val Ala Ile Asp Thr Asn 
465                 470                 475                 480 

Ile Asp Ser Pro Tyr Asn Val Tyr Lys Asn Val Gly Leu Met Pro Gly 
                485                 490                 495     

Pro Val Asp Ser Pro Ser Leu Asp Ala Ile Glu Ser Ser Ile Asn Gln 
            500                 505                 510         

Thr Lys Ser Asp Asn Leu Tyr Phe Val Ala Asp Val Thr Glu Gly Lys 
        515                 520                 525             

Val Tyr Tyr Ala Asn Asn Gln Glu Asp His Asp Arg Asn Val Ala Glu 
    530                 535                 540                 

His Val Asn Ser Lys Leu Asn 
545                 550     

<210>   88
<211>   205
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   88
Met Lys Gln Glu Arg Phe Pro Leu Val Ser Asp Asp Glu Val Met Leu 
1               5                   10                  15      

Thr Glu Met Pro Val Met Asn Leu Tyr Asp Glu Ser Asp Leu Ile Ser 
            20                  25                  30          

Asn Ile Lys Gly Glu Tyr Arg Asp Lys Asn Tyr Leu Glu Trp Ala Pro 
        35                  40                  45              

Ile Ala Glu Glu Lys Pro Val Lys Pro Ile Glu Lys Gln Val Glu Lys 
    50                  55                  60                  

Pro Lys Lys Ala Pro Leu Gly Val Lys Lys Glu Gly Lys Ser Tyr Ala 
65                  70                  75                  80  

Glu Val Ala Arg Glu Glu Ala Arg Ala Asp Leu Lys Lys Lys Arg Ser 
                85                  90                  95      

Ala Asn Tyr Leu Thr Gln Asp Phe Ser Leu Ala Arg Arg His Ser Gln 
            100                 105                 110         

Pro Ser Leu Val Arg Gln Gly Asn Gln Pro Thr Ala Pro Phe Gln Lys 
        115                 120                 125             

Glu Asn Pro Gly Glu Phe Val Lys Tyr Ser Gln Lys Leu Thr Gln Ser 
    130                 135                 140                 

His Tyr Ile Leu Ala Glu Glu Val His Ser Ile Pro Thr Lys Asn Glu 
145                 150                 155                 160 

Glu Val Ser Ala Pro Ala Pro Lys Lys Asn Asn Tyr Asp Phe Leu Lys 
                165                 170                 175     

Lys Ser Gln Ile Tyr Asn Lys Lys Ser Lys Gln Thr Glu Gln Glu Arg 
            180                 185                 190         

Arg Val Ala Gln Glu Leu Asn Leu Thr Arg Met Thr Glu 
        195                 200                 205 

<210>   89
<211>   652
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   89
Met Lys Lys Ser Lys Ser Lys Tyr Leu Thr Leu Ala Gly Leu Val Leu 
1               5                   10                  15      

Gly Thr Gly Val Leu Leu Ser Ala Cys Gly Asn Ser Ser Thr Ala Ser 
            20                  25                  30          

Lys Thr Tyr Asn Tyr Val Tyr Ser Ser Asp Pro Ser Ser Leu Asn Tyr 
        35                  40                  45              

Leu Ala Glu Asn Arg Ala Ala Thr Ser Asp Ile Val Ala Asn Leu Val 
    50                  55                  60                  

Asp Gly Leu Leu Glu Asn Asp Gln Tyr Gly Asn Ile Ile Pro Ser Leu 
65                  70                  75                  80  

Ala Glu Asp Trp Thr Val Ser Gln Asp Gly Leu Thr Tyr Thr Tyr Lys 
                85                  90                  95      

Leu Arg Lys Asp Ala Lys Trp Phe Thr Ser Glu Gly Glu Glu Tyr Ala 
            100                 105                 110         

Pro Val Thr Ala Gln Asp Phe Val Thr Gly Leu Gln Tyr Ala Ala Asp 
        115                 120                 125             

Lys Lys Ser Glu Ala Leu Tyr Leu Val Gln Asp Ser Val Ala Gly Leu 
    130                 135                 140                 

Asp Asp Tyr Ile Thr Gly Lys Thr Ser Asp Phe Ser Thr Val Gly Val 
145                 150                 155                 160 

Lys Ala Leu Asp Asp Gln Thr Val Gln Tyr Thr Leu Val Lys Pro Glu 
                165                 170                 175     

Leu Tyr Trp Asn Ser Lys Thr Leu Ala Thr Ile Leu Phe Pro Val Asn 
            180                 185                 190         

Ala Asp Phe Leu Lys Ser Lys Gly Asp Asp Phe Gly Lys Ala Asp Pro 
        195                 200                 205             

Ser Ser Ile Leu Tyr Asn Gly Pro Phe Leu Met Lys Ala Leu Val Ser 
    210                 215                 220                 

Lys Ser Ala Ile Glu Tyr Lys Lys Asn Pro Asn Tyr Trp Asp Ala Lys 
225                 230                 235                 240 

Asn Val Phe Val Asp Asp Val Lys Leu Thr Tyr Tyr Asp Gly Ser Asp 
                245                 250                 255     

Gln Glu Ser Leu Glu Arg Asn Phe Thr Ala Gly Ala Tyr Thr Thr Ala 
            260                 265                 270         

Arg Leu Phe Pro Asn Ser Ser Ser Tyr Glu Gly Ile Lys Glu Lys Tyr 
        275                 280                 285             

Lys Asn Asn Ile Ile Tyr Ser Met Gln Asn Ser Thr Ser Tyr Phe Phe 
    290                 295                 300                 

Asn Phe Asn Leu Asp Arg Lys Ser Tyr Asn Tyr Thr Ser Lys Thr Ser 
305                 310                 315                 320 

Asp Ile Glu Lys Lys Ser Thr Gln Glu Ala Val Leu Asn Lys Asn Phe 
                325                 330                 335     

Arg Gln Ala Ile Asn Phe Ala Phe Asp Arg Thr Ser Tyr Gly Ala Gln 
            340                 345                 350         

Ser Glu Gly Lys Glu Gly Ala Thr Lys Ile Leu Arg Asn Leu Val Val 
        355                 360                 365             

Pro Pro Asn Phe Val Ser Ile Lys Gly Lys Asp Phe Gly Glu Val Val 
    370                 375                 380                 

Ala Ser Lys Met Val Asn Tyr Gly Lys Glu Trp Gln Gly Ile Asn Phe 
385                 390                 395                 400 

Ala Asp Gly Gln Asp Pro Tyr Tyr Asn Pro Glu Lys Ala Lys Ala Lys 
                405                 410                 415     

Phe Ala Glu Ala Lys Lys Glu Leu Glu Ala Lys Gly Val Gln Phe Pro 
            420                 425                 430         

Ile His Leu Asp Lys Thr Val Glu Val Thr Asp Lys Val Gly Ile Gln 
        435                 440                 445             

Gly Val Ser Ser Ile Lys Gln Ser Ile Glu Ser Val Leu Gly Ser Asp 
    450                 455                 460                 

Asn Val Val Ile Asp Ile Gln Gln Leu Thr Ser Asp Glu Phe Asp Ser 
465                 470                 475                 480 

Ser Gly Tyr Phe Ala Gln Thr Ala Ala Gln Lys Asp Tyr Asp Leu Tyr 
                485                 490                 495     

His Gly Gly Trp Gly Pro Asp Tyr Gln Asp Pro Ser Thr Tyr Leu Asp 
            500                 505                 510         

Ile Phe Asn Thr Asn Ser Gly Gly Phe Leu Gln Asn Leu Gly Leu Glu 
        515                 520                 525             

Pro Gly Glu Ala Asn Asp Lys Ala Lys Ala Val Gly Leu Asp Val Tyr 
    530                 535                 540                 

Thr Gln Met Leu Glu Glu Ala Asn Lys Glu Gln Asp Pro Ala Lys Arg 
545                 550                 555                 560 

Tyr Glu Lys Tyr Ala Asp Ile Gln Ala Trp Leu Ile Asp Ser Ser Leu 
                565                 570                 575     

Val Leu Pro Ser Val Ser Arg Gly Gly Thr Pro Ser Leu Arg Arg Thr 
            580                 585                 590         

Val Pro Phe Ala Ala Ala Tyr Gly Leu Thr Gly Thr Lys Gly Val Glu 
        595                 600                 605             

Ser Tyr Lys Tyr Leu Lys Val Gln Asp Lys Ile Val Thr Thr Asp Glu 
    610                 615                 620                 

Tyr Ala Lys Ala Arg Glu Lys Trp Leu Lys Glu Lys Glu Glu Ser Asn 
625                 630                 635                 640 

Lys Lys Ala Gln Glu Glu Leu Ala Lys His Val Lys 
                645                 650         

<210>   90
<211>   158
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   90
Met Ala Lys Glu Pro Trp Gln Glu Asp Ile Tyr Asp Gln Glu Glu Ser 
1               5                   10                  15      

Arg Ala Glu Arg Arg His Arg Asn His Gly Gly Ala Asp Arg Met Ala 
            20                  25                  30          

Asn Arg Ile Leu Thr Ile Leu Ala Ser Ile Phe Phe Val Ile Val Val 
        35                  40                  45              

Val Met Val Ile Val Leu Ile Tyr Leu Ser Ser Gly Gly Ser Asn Arg 
    50                  55                  60                  

Thr Ala Ala Leu Lys Gly Phe His Asp Ser Asp Ala Ser Val Val Gln 
65                  70                  75                  80  

Ile Ser Ser Ser Ser Ser Ser Gln Pro Glu Gln Ser Ser Glu Pro Glu 
                85                  90                  95      

Ser Thr Ser Ser Ser Ser Glu Glu Ala Ala Asn Pro Glu Gly Thr Ile 
            100                 105                 110         

Lys Val Leu Ala Gly Glu Gly Glu Ala Ala Ile Ala Ala Arg Ala Gly 
        115                 120                 125             

Ile Ser Ile Ala Gln Leu Glu Ala Leu Asn Pro Gly His Met Ala Thr 
    130                 135                 140                 

Gly Ser Trp Phe Ala Asn Pro Gly Asp Val Ile Lys Ile Lys 
145                 150                 155             

<210>   91
<211>   262
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   91
Met Pro Ile Thr Ser Leu Glu Ile Lys Asp Lys Thr Phe Gly Thr Arg 
1               5                   10                  15      

Phe Arg Gly Phe Asp Pro Glu Glu Val Asp Glu Phe Leu Asp Ile Val 
            20                  25                  30          

Val Arg Asp Tyr Glu Asp Leu Val Arg Ala Asn His Asp Lys Asn Leu 
        35                  40                  45              

Arg Ile Lys Ser Leu Glu Glu Arg Leu Ser Tyr Phe Asp Glu Ile Lys 
    50                  55                  60                  

Asp Ser Leu Ser Gln Ser Val Leu Ile Ala Gln Asp Thr Ala Glu Arg 
65                  70                  75                  80  

Val Lys Gln Ala Ala His Glu Arg Ser Asn Asn Ile Ile His Gln Ala 
                85                  90                  95      

Glu Gln Asp Ala Gln Arg Leu Leu Glu Glu Ala Lys Tyr Lys Ala Asn 
            100                 105                 110         

Glu Ile Leu Arg Gln Ala Thr Asp Asn Ala Lys Lys Val Ala Val Glu 
        115                 120                 125             

Thr Glu Glu Leu Lys Asn Lys Ser Arg Val Phe His Gln Arg Leu Lys 
    130                 135                 140                 

Ser Thr Ile Glu Ser Gln Leu Ala Ile Val Glu Ser Ser Asp Trp Glu 
145                 150                 155                 160 

Asp Ile Leu Arg Pro Thr Ala Thr Tyr Leu Gln Thr Ser Asp Glu Ala 
                165                 170                 175     

Phe Lys Glu Val Val Ser Glu Val Leu Gly Glu Pro Ile Pro Ala Pro 
            180                 185                 190         

Ile Glu Glu Glu Pro Ile Asp Met Thr Arg Gln Phe Ser Gln Ala Glu 
        195                 200                 205             

Met Ala Glu Leu Gln Ala Arg Ile Glu Val Ala Asp Lys Glu Leu Ser 
    210                 215                 220                 

Glu Phe Glu Ala Gln Ile Lys Gln Glu Val Glu Ala Pro Thr Pro Val 
225                 230                 235                 240 

Val Ser Pro Gln Val Glu Glu Glu Pro Leu Leu Ile Gln Leu Ala Gln 
                245                 250                 255     

Cys Met Lys Asn Gln Lys 
            260         

<210>   92
<211>   179
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   92
Met Ser Leu Lys Asp Arg Phe Asp Arg Phe Ile Asp Tyr Phe Thr Glu 
1               5                   10                  15      

Asp Glu Asp Ser Ser Leu Pro Tyr Glu Lys Arg Asp Glu Pro Val Phe 
            20                  25                  30          

Thr Ser Val Asn Ser Ser Gln Glu Pro Ala Leu Pro Met Asn Gln Pro 
        35                  40                  45              

Ser Gln Ser Ala Gly Thr Lys Glu Asn Asn Ile Thr Arg Leu His Ala 
    50                  55                  60                  

Arg Gln Gln Glu Leu Ala Asn Gln Ser Gln Arg Ala Thr Asp Lys Val 
65                  70                  75                  80  

Ile Ile Asp Val Arg Tyr Pro Arg Lys Tyr Glu Asp Ala Thr Glu Ile 
                85                  90                  95      

Val Asp Leu Leu Ala Gly Asn Glu Ser Ile Leu Ile Asp Phe Gln Tyr 
            100                 105                 110         

Met Thr Glu Val Gln Ala Arg Arg Cys Leu Asp Tyr Leu Asp Gly Ala 
        115                 120                 125             

Cys His Val Leu Ala Gly Asn Leu Lys Lys Val Ala Ser Thr Met Tyr 
    130                 135                 140                 

Leu Leu Thr Pro Val Asn Val Ile Val Asn Val Glu Asp Ile Arg Leu 
145                 150                 155                 160 

Pro Asp Glu Asp Gln Gln Gly Glu Phe Gly Phe Asp Met Lys Arg Asn 
                165                 170                 175     

Arg Val Arg 
            

<210>   93
<211>   305
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   93
Met Ser Asp Leu Lys Lys Tyr Glu Gly Val Ile Pro Ala Phe Tyr Ala 
1               5                   10                  15      

Cys Tyr Asp Asp Gln Gly Glu Val Ser Pro Glu Arg Thr Arg Ala Leu 
            20                  25                  30          

Val Gln Tyr Phe Ile Asp Lys Gly Val Gln Gly Leu Tyr Val Asn Gly 
        35                  40                  45              

Ser Ser Gly Glu Cys Ile Tyr Gln Ser Val Glu Asp Arg Lys Leu Ile 
    50                  55                  60                  

Leu Glu Glu Val Met Ala Val Ala Lys Gly Lys Leu Thr Ile Ile Ala 
65                  70                  75                  80  

His Val Ala Cys Asn Asn Thr Lys Asp Ser Met Glu Leu Ala Arg His 
                85                  90                  95      

Ala Glu Ser Leu Gly Val Asp Ala Ile Ala Thr Ile Pro Pro Ile Tyr 
            100                 105                 110         

Phe Arg Leu Pro Glu Tyr Ser Val Ala Lys Tyr Trp Asn Asp Ile Ser 
        115                 120                 125             

Ser Ala Ala Pro Asn Thr Asp Tyr Val Ile Tyr Asn Ile Pro Gln Leu 
    130                 135                 140                 

Ala Gly Val Ala Leu Thr Pro Ser Leu Tyr Thr Glu Met Leu Lys Asn 
145                 150                 155                 160 

Pro Arg Val Ile Gly Val Lys Asn Ser Ser Met Pro Val Gln Asp Ile 
                165                 170                 175     

Gln Thr Phe Val Ser Leu Gly Gly Glu Asp His Ile Val Phe Asn Gly 
            180                 185                 190         

Pro Asp Glu Gln Phe Leu Gly Gly Arg Leu Met Gly Ala Arg Ala Gly 
        195                 200                 205             

Ile Gly Gly Thr Tyr Gly Ala Met Pro Glu Leu Phe Leu Lys Leu Asn 
    210                 215                 220                 

Gln Leu Ile Ala Asp Lys Asp Leu Glu Thr Ala Arg Glu Leu Gln Tyr 
225                 230                 235                 240 

Ala Ile Asn Ala Ile Ile Gly Lys Leu Thr Ser Ala His Gly Asn Met 
                245                 250                 255     

Tyr Gly Val Ile Lys Glu Val Leu Lys Ile Asn Glu Gly Leu Asn Ile 
            260                 265                 270         

Gly Ser Val Arg Ser Pro Leu Thr Pro Val Thr Glu Glu Asp Arg Pro 
        275                 280                 285             

Val Val Glu Ala Ala Ala Ala Leu Ile Arg Glu Thr Lys Glu Arg Phe 
    290                 295                 300                 

Leu 
305 

<210>   94
<211>   659
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   94
Met Ile Gln Ile Gly Lys Ile Phe Ala Gly Arg Tyr Arg Ile Val Lys 
1               5                   10                  15      

Gln Ile Gly Arg Gly Gly Met Ala Asp Val Tyr Leu Ala Lys Asp Leu 
            20                  25                  30          

Ile Leu Asp Gly Glu Glu Val Ala Val Lys Val Leu Arg Thr Asn Tyr 
        35                  40                  45              

Gln Thr Asp Pro Ile Ala Val Ala Arg Phe Gln Arg Glu Ala Arg Ala 
    50                  55                  60                  

Met Ala Asp Leu Asp His Pro His Ile Val Arg Ile Thr Asp Ile Gly 
65                  70                  75                  80  

Glu Glu Asp Gly Gln Gln Tyr Leu Ala Met Glu Tyr Val Ala Gly Leu 
                85                  90                  95      

Asp Leu Lys Arg Tyr Ile Lys Glu His Tyr Pro Leu Ser Asn Glu Glu 
            100                 105                 110         

Ala Val Arg Ile Met Gly Gln Ile Leu Leu Ala Met Arg Leu Ala His 
        115                 120                 125             

Thr Arg Gly Ile Val His Arg Asp Leu Lys Pro Gln Asn Ile Leu Leu 
    130                 135                 140                 

Thr Pro Asp Gly Thr Ala Lys Val Thr Asp Phe Gly Ile Ala Val Ala 
145                 150                 155                 160 

Phe Ala Glu Thr Ser Leu Thr Gln Thr Asn Ser Met Leu Gly Ser Val 
                165                 170                 175     

His Tyr Leu Ser Pro Glu Gln Ala Arg Gly Ser Lys Ala Thr Val Gln 
            180                 185                 190         

Ser Asp Ile Tyr Ala Met Gly Ile Ile Phe Tyr Glu Met Leu Thr Gly 
        195                 200                 205             

His Ile Pro Tyr Asp Gly Asp Ser Ala Val Thr Ile Ala Leu Gln His 
    210                 215                 220                 

Phe Gln Lys Pro Leu Pro Ser Val Ile Ala Glu Asn Pro Ser Val Pro 
225                 230                 235                 240 

Gln Ala Leu Glu Asn Val Ile Ile Lys Ala Thr Ala Lys Lys Leu Thr 
                245                 250                 255     

Asn Arg Tyr Arg Ser Val Ser Glu Met Tyr Val Asp Leu Ser Ser Ser 
            260                 265                 270         

Leu Ser Tyr Asn Arg Arg Asn Glu Ser Lys Leu Ile Phe Asp Glu Thr 
        275                 280                 285             

Ser Lys Ala Asp Thr Lys Thr Leu Pro Lys Val Ser Gln Ser Thr Leu 
    290                 295                 300                 

Thr Ser Ile Pro Lys Val Gln Ala Gln Thr Glu His Lys Ser Ile Lys 
305                 310                 315                 320 

Asn Pro Ser Gln Ala Val Thr Glu Glu Thr Tyr Gln Pro Gln Ala Pro 
                325                 330                 335     

Lys Lys His Arg Phe Lys Met Arg Tyr Leu Ile Leu Leu Ala Ser Leu 
            340                 345                 350         

Val Leu Val Ala Ala Ser Leu Ile Trp Ile Leu Ser Arg Thr Pro Ala 
        355                 360                 365             

Thr Ile Ala Ile Pro Asp Val Ala Gly Gln Thr Val Ala Glu Ala Lys 
    370                 375                 380                 

Ala Thr Leu Lys Lys Ala Asn Phe Glu Ile Gly Glu Glu Lys Thr Glu 
385                 390                 395                 400 

Ala Ser Glu Lys Val Glu Glu Gly Arg Ile Ile Arg Thr Asp Pro Gly 
                405                 410                 415     

Ala Gly Thr Gly Arg Lys Glu Gly Thr Lys Ile Asn Leu Val Val Ser 
            420                 425                 430         

Ser Gly Lys Gln Ser Phe Gln Ile Ser Asn Tyr Val Gly Arg Lys Ser 
        435                 440                 445             

Ser Asp Val Ile Ala Glu Leu Lys Glu Lys Lys Val Pro Asp Asn Leu 
    450                 455                 460                 

Ile Lys Ile Glu Glu Glu Glu Ser Asn Glu Ser Glu Ala Gly Thr Val 
465                 470                 475                 480 

Leu Lys Gln Ser Leu Pro Glu Gly Thr Thr Tyr Asp Leu Ser Lys Ala 
                485                 490                 495     

Thr Gln Ile Val Leu Thr Val Ala Lys Lys Ala Thr Thr Ile Gln Leu 
            500                 505                 510         

Gly Asn Tyr Ile Gly Arg Asn Ser Thr Glu Val Ile Ser Glu Leu Lys 
        515                 520                 525             

Gln Lys Lys Val Pro Glu Asn Leu Ile Lys Ile Glu Glu Glu Glu Ser 
    530                 535                 540                 

Ser Glu Ser Glu Pro Gly Thr Ile Met Lys Gln Ser Pro Gly Ala Gly 
545                 550                 555                 560 

Thr Thr Tyr Asp Val Ser Lys Pro Thr Gln Ile Val Leu Thr Val Ala 
                565                 570                 575     

Lys Lys Val Thr Ser Val Ala Met Pro Ser Tyr Ile Gly Ser Ser Leu 
            580                 585                 590         

Glu Phe Thr Lys Asn Asn Leu Ile Gln Ile Val Gly Ile Lys Glu Ala 
        595                 600                 605             

Asn Ile Glu Val Val Glu Val Thr Thr Ala Pro Ala Gly Ser Ala Glu 
    610                 615                 620                 

Gly Met Val Val Glu Gln Ser Pro Arg Ala Gly Glu Lys Val Asp Leu 
625                 630                 635                 640 

Asn Lys Thr Arg Val Lys Ile Ser Ile Tyr Lys Pro Lys Thr Thr Ser 
                645                 650                 655     

Ala Thr Pro 
            

<210>   95
<211>   311
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   95
Met Thr Lys Leu Ile Phe Met Gly Thr Pro Asp Phe Ser Ala Thr Val 
1               5                   10                  15      

Leu Lys Gly Leu Leu Thr Asp Asp Arg Tyr Glu Ile Leu Ala Val Val 
            20                  25                  30          

Thr Gln Pro Asp Arg Ala Val Gly Arg Lys Lys Val Ile Gln Glu Thr 
        35                  40                  45              

Pro Val Lys Gln Ala Ala Lys Glu Ala Gly Leu Ser Ile Tyr Gln Pro 
    50                  55                  60                  

Glu Lys Leu Ser Gly Ser Pro Glu Met Glu Asp Leu Met Lys Leu Gly 
65                  70                  75                  80  

Ala Asp Gly Ile Val Thr Ala Ala Phe Gly Gln Phe Leu Pro Ser Lys 
                85                  90                  95      

Leu Leu Asp Ser Met Asp Phe Ala Val Asn Val His Ala Ser Leu Leu 
            100                 105                 110         

Pro Arg His Arg Gly Gly Ala Pro Ile His Tyr Ala Leu Ile Gln Gly 
        115                 120                 125             

Asp Glu Glu Ala Gly Val Thr Ile Met Glu Met Val Lys Glu Met Asp 
    130                 135                 140                 

Ala Gly Asp Met Ile Ser Arg Arg Ser Ile Pro Ile Thr Asp Glu Asp 
145                 150                 155                 160 

Asn Val Gly Thr Leu Phe Glu Lys Leu Ala Leu Val Gly Arg Asp Leu 
                165                 170                 175     

Leu Leu Asp Thr Leu Pro Ala Tyr Ile Ala Gly Asp Ile Lys Pro Glu 
            180                 185                 190         

Pro Gln Asp Thr Ser Gln Val Thr Phe Ser Pro Asn Ile Lys Pro Glu 
        195                 200                 205             

Glu Glu Lys Leu Asp Trp Asn Lys Thr Asn Arg Gln Leu Phe Asn Gln 
    210                 215                 220                 

Ile Arg Gly Met Asn Pro Trp Pro Val Ala His Thr Phe Leu Lys Gly 
225                 230                 235                 240 

Asp Arg Phe Lys Ile Tyr Glu Ala Leu Pro Val Glu Gly Gln Gly Asn 
                245                 250                 255     

Pro Gly Glu Ile Leu Ser Ile Gly Lys Lys Glu Leu Ile Val Ala Thr 
            260                 265                 270         

Ala Glu Gly Ala Leu Ser Leu Lys Gln Val Gln Pro Ala Gly Lys Pro 
        275                 280                 285             

Lys Met Asp Ile Ala Ser Phe Leu Asn Gly Val Gly Arg Thr Leu Thr 
    290                 295                 300                 

Val Gly Glu Arg Phe Gly Asp 
305                 310     

<210>   96
<211>   790
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   96
Val Phe Arg Arg Leu Gly Gln Asp Phe Gln Leu Arg Lys Val Lys Lys 
1               5                   10                  15      

Ile Leu Lys Gln Ile Asn Ala Leu Lys Gly Lys Met Ser Ser Leu Ser 
            20                  25                  30          

Asp Gln Glu Leu Val Ala Lys Thr Val Glu Phe Arg Gln Arg Leu Ser 
        35                  40                  45              

Glu Gly Glu Ser Leu Asp Asp Ile Leu Val Glu Ala Phe Ala Val Val 
    50                  55                  60                  

Arg Glu Ala Asp Lys Arg Ile Leu Gly Met Phe Pro Tyr Asp Val Gln 
65                  70                  75                  80  

Val Met Gly Ala Ile Val Met His Tyr Gly Asn Val Ala Glu Met Asn 
                85                  90                  95      

Thr Gly Glu Gly Lys Thr Leu Thr Ala Thr Met Pro Val Tyr Leu Asn 
            100                 105                 110         

Ala Phe Ser Gly Glu Gly Val Met Val Val Thr Pro Asn Glu Tyr Leu 
        115                 120                 125             

Ser Lys Arg Asp Ala Glu Glu Met Gly Gln Val Tyr Arg Phe Leu Gly 
    130                 135                 140                 

Leu Thr Ile Gly Val Pro Phe Thr Glu Asp Pro Lys Lys Glu Met Lys 
145                 150                 155                 160 

Ala Glu Glu Lys Lys Leu Ile Tyr Ala Ser Asp Ile Ile Tyr Thr Thr 
                165                 170                 175     

Asn Ser Asn Leu Gly Phe Asp Tyr Leu Asn Asp Asn Leu Ala Ser Asn 
            180                 185                 190         

Glu Glu Gly Lys Phe Leu Arg Pro Phe Asn Tyr Val Ile Ile Asp Glu 
        195                 200                 205             

Ile Asp Asp Ile Leu Leu Asp Ser Ala Gln Thr Pro Leu Ile Ile Ala 
    210                 215                 220                 

Gly Ser Pro Arg Val Gln Ser Asn Tyr Tyr Ala Ile Ile Asp Thr Leu 
225                 230                 235                 240 

Val Thr Thr Leu Val Glu Gly Glu Asp Tyr Ile Phe Lys Glu Glu Lys 
                245                 250                 255     

Glu Glu Val Trp Leu Thr Thr Lys Gly Ala Lys Ser Ala Glu Asn Phe 
            260                 265                 270         

Leu Gly Ile Asp Asn Leu Tyr Lys Glu Glu His Ala Ser Phe Ala Arg 
        275                 280                 285             

His Leu Val Tyr Ala Ile Arg Ala His Lys Leu Phe Thr Lys Asp Lys 
    290                 295                 300                 

Asp Tyr Ile Ile Arg Gly Asn Glu Met Val Leu Val Asp Lys Gly Thr 
305                 310                 315                 320 

Gly Arg Leu Met Glu Met Thr Lys Leu Gln Gly Gly Leu His Gln Ala 
                325                 330                 335     

Ile Glu Ala Lys Glu His Val Lys Leu Ser Pro Glu Thr Arg Ala Met 
            340                 345                 350         

Ala Ser Ile Thr Tyr Gln Ser Leu Phe Lys Met Phe Asn Lys Ile Ser 
        355                 360                 365             

Gly Met Thr Gly Thr Gly Lys Val Ala Glu Lys Glu Phe Ile Glu Thr 
    370                 375                 380                 

Tyr Asn Met Ser Val Val Arg Ile Pro Thr Asn Arg Pro Arg Gln Arg 
385                 390                 395                 400 

Ile Asp Tyr Pro Asp Asn Leu Tyr Ile Thr Leu Pro Glu Lys Val Tyr 
                405                 410                 415     

Ala Ser Leu Glu Tyr Ile Lys Gln Tyr His Ala Lys Gly Asn Pro Leu 
            420                 425                 430         

Leu Val Phe Val Gly Ser Val Glu Met Ser Gln Leu Tyr Ser Ser Leu 
        435                 440                 445             

Leu Phe Arg Glu Gly Ile Ala His Asn Val Leu Asn Ala Asn Asn Ala 
    450                 455                 460                 

Ala Arg Glu Ala Gln Ile Ile Ser Glu Ser Gly Gln Met Gly Ala Val 
465                 470                 475                 480 

Thr Val Ala Thr Ser Met Ala Gly Arg Gly Thr Asp Ile Lys Leu Gly 
                485                 490                 495     

Lys Gly Val Ala Glu Leu Gly Gly Leu Ile Val Ile Gly Thr Glu Arg 
            500                 505                 510         

Met Glu Ser Gln Arg Ile Asp Leu Gln Ile Arg Gly Arg Ser Gly Arg 
        515                 520                 525             

Gln Gly Asp Pro Gly Met Ser Lys Phe Phe Val Ser Leu Glu Asp Asp 
    530                 535                 540                 

Val Ile Lys Lys Phe Gly Pro Ser Trp Val His Lys Lys Tyr Lys Asp 
545                 550                 555                 560 

Tyr Gln Val Gln Asp Met Thr Gln Pro Glu Val Leu Lys Gly Arg Lys 
                565                 570                 575     

Tyr Arg Lys Leu Val Glu Lys Ala Gln His Ala Ser Asp Ser Ala Gly 
            580                 585                 590         

Arg Ser Ala Arg Arg Gln Thr Leu Glu Tyr Ala Glu Ser Met Asn Ile 
        595                 600                 605             

Gln Arg Asp Ile Val Tyr Lys Glu Arg Asn Arg Leu Ile Asp Gly Ser 
    610                 615                 620                 

Arg Asp Leu Glu Asp Val Val Val Asp Ile Ile Glu Arg Tyr Thr Glu 
625                 630                 635                 640 

Glu Val Ala Ala Asp His Tyr Ala Ser Arg Glu Leu Leu Phe His Phe 
                645                 650                 655     

Ile Val Thr Asn Ile Ser Phe His Val Lys Glu Val Pro Asp Tyr Ile 
            660                 665                 670         

Asp Val Thr Asp Lys Thr Ala Val Arg Ser Phe Met Lys Gln Val Ile 
        675                 680                 685             

Asp Lys Glu Leu Ser Glu Lys Lys Glu Leu Leu Asn Gln His Asp Leu 
    690                 695                 700                 

Tyr Glu Gln Phe Leu Arg Leu Ser Leu Leu Lys Ala Ile Asp Asp Asn 
705                 710                 715                 720 

Trp Val Glu Gln Val Asp Tyr Leu Gln Gln Leu Ser Met Ala Ile Gly 
                725                 730                 735     

Gly Gln Ser Ala Ser Gln Lys Asn Pro Ile Val Glu Tyr Tyr Gln Glu 
            740                 745                 750         

Ala Tyr Ala Gly Phe Glu Ala Met Lys Glu Gln Ile His Ala Asp Met 
        755                 760                 765             

Val Arg Asn Leu Leu Met Gly Leu Val Glu Val Thr Pro Lys Gly Glu 
    770                 775                 780                 

Ile Val Thr His Phe Pro 
785                 790 

<210>   97
<211>   4776
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   97
Met Thr Glu Thr Val Glu Asp Lys Val Ser His Ser Ile Thr Gly Leu 
1               5                   10                  15      

Asp Ile Leu Lys Gly Ile Val Ala Ala Gly Ala Val Ile Ser Gly Thr 
            20                  25                  30          

Val Ala Thr Gln Thr Lys Val Phe Thr Asn Glu Ser Ala Val Leu Glu 
        35                  40                  45              

Lys Thr Val Glu Lys Thr Asp Ala Leu Ala Thr Asn Asp Thr Val Val 
    50                  55                  60                  

Leu Gly Thr Ile Ser Thr Ser Asn Ser Ala Ser Ser Thr Ser Leu Ser 
65                  70                  75                  80  

Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser 
                85                  90                  95      

Ala Ser Thr Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser 
            100                 105                 110         

Ala Ser Thr Ser Ile Ser Ala Ser Ser Thr Val Val Gly Ser Gln Thr 
        115                 120                 125             

Ala Ala Ala Thr Glu Ala Thr Ala Lys Lys Val Glu Glu Asp Arg Lys 
    130                 135                 140                 

Lys Pro Ala Ser Asp Tyr Val Ala Ser Val Thr Asn Val Asn Leu Gln 
145                 150                 155                 160 

Ser Tyr Ala Lys Arg Arg Lys Arg Ser Val Asp Ser Ile Glu Gln Leu 
                165                 170                 175     

Leu Ala Ser Ile Lys Asn Ala Ala Val Phe Ser Gly Asn Thr Ile Val 
            180                 185                 190         

Asn Gly Ala Pro Ala Ile Asn Ala Ser Leu Asn Ile Ala Lys Ser Glu 
        195                 200                 205             

Thr Lys Val Tyr Thr Gly Glu Gly Val Asp Ser Val Tyr Arg Val Pro 
    210                 215                 220                 

Ile Tyr Tyr Lys Leu Lys Val Thr Asn Asp Gly Ser Lys Leu Thr Phe 
225                 230                 235                 240 

Thr Tyr Thr Val Thr Tyr Val Asn Pro Lys Thr Asn Asp Leu Gly Asn 
                245                 250                 255     

Ile Ser Ser Met Arg Pro Gly Tyr Ser Ile Tyr Asn Ser Gly Thr Ser 
            260                 265                 270         

Thr Gln Thr Met Leu Thr Leu Gly Ser Asp Leu Gly Lys Pro Ser Gly 
        275                 280                 285             

Val Lys Asn Tyr Ile Thr Asp Lys Asn Gly Arg Gln Val Leu Ser Tyr 
    290                 295                 300                 

Asn Thr Ser Thr Met Thr Thr Gln Gly Ser Gly Tyr Thr Trp Gly Asn 
305                 310                 315                 320 

Gly Ala Gln Met Asn Gly Phe Phe Ala Lys Lys Gly Tyr Gly Leu Thr 
                325                 330                 335     

Ser Ser Trp Thr Val Pro Ile Thr Gly Thr Asp Thr Ser Phe Thr Phe 
            340                 345                 350         

Thr Pro Tyr Ala Ala Arg Thr Asp Arg Ile Gly Ile Asn Tyr Phe Asn 
        355                 360                 365             

Gly Gly Gly Lys Val Val Glu Ser Ser Thr Thr Ser Gln Ser Leu Ser 
    370                 375                 380                 

Gln Ser Lys Ser Leu Ser Val Ser Ala Ser Gln Ser Ala Ser Ala Ser 
385                 390                 395                 400 

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
                405                 410                 415     

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Val Ser 
            420                 425                 430         

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
        435                 440                 445             

Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser 
    450                 455                 460                 

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
465                 470                 475                 480 

Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser 
                485                 490                 495     

Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser 
            500                 505                 510         

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Gly Ser 
        515                 520                 525             

Ala Ser Thr Ser Thr Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
    530                 535                 540                 

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Ile Ser Ala Ser Glu Ser 
545                 550                 555                 560 

Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Thr Ser Ala Ser 
                565                 570                 575     

Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser 
            580                 585                 590         

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
        595                 600                 605             

Ala Ser Thr Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser 
    610                 615                 620                 

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
625                 630                 635                 640 

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
                645                 650                 655     

Thr Ser Ala Ser Val Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
            660                 665                 670         

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser 
        675                 680                 685             

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
    690                 695                 700                 

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
705                 710                 715                 720 

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser 
                725                 730                 735     

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
            740                 745                 750         

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
        755                 760                 765             

Thr Ser Ala Ser Ala Ser Ala Ser Ile Ser Ala Ser Glu Ser Ala Ser 
    770                 775                 780                 

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
785                 790                 795                 800 

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser 
                805                 810                 815     

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
            820                 825                 830         

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
        835                 840                 845             

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
    850                 855                 860                 

Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
865                 870                 875                 880 

Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
                885                 890                 895     

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
            900                 905                 910         

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
        915                 920                 925             

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Thr Ser 
    930                 935                 940                 

Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
945                 950                 955                 960 

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
                965                 970                 975     

Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
            980                 985                 990         

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
        995                 1000                1005            

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Ile Ser 
    1010                1015                1020                

Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
1025                1030                1035                1040

Ala Ser Val Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
                1045                1050                1055    

Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
            1060                1065                1070        

Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
        1075                1080                1085            

Ala Ser Ala Ser Ala Ser Ile Ser Ala Ser Glu Ser Ala Ser Thr Ser 
    1090                1095                1100                

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
1105                1110                1115                1120

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser 
                1125                1130                1135    

Thr Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser 
            1140                1145                1150        

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
        1155                1160                1165            

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
    1170                1175                1180                

Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser 
1185                1190                1195                1200

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
                1205                1210                1215    

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
            1220                1225                1230        

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
        1235                1240                1245            

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
    1250                1255                1260                

Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
1265                1270                1275                1280

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
                1285                1290                1295    

Ala Ser Ala Ser Thr Ser Ala Ser Val Ser Ala Ser Thr Ser Ala Ser 
            1300                1305                1310        

Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
        1315                1320                1325            

Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser 
    1330                1335                1340                

Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser 
1345                1350                1355                1360

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
                1365                1370                1375    

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
            1380                1385                1390        

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
        1395                1400                1405            

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
    1410                1415                1420                

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
1425                1430                1435                1440

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
                1445                1450                1455    

Ala Ser Ala Ser Ile Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser 
            1460                1465                1470        

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
        1475                1480                1485            

Val Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
    1490                1495                1500                

Ala Ser Ala Ser Ile Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser 
1505                1510                1515                1520

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
                1525                1530                1535    

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Ile Ser Ala Ser 
            1540                1545                1550        

Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
        1555                1560                1565            

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
    1570                1575                1580                

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
1585                1590                1595                1600

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
                1605                1610                1615    

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
            1620                1625                1630        

Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
        1635                1640                1645            

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
    1650                1655                1660                

Val Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser 
1665                1670                1675                1680

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
                1685                1690                1695    

Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser 
            1700                1705                1710        

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
        1715                1720                1725            

Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
    1730                1735                1740                

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
1745                1750                1755                1760

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
                1765                1770                1775    

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Ile Ser 
            1780                1785                1790        

Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser 
        1795                1800                1805            

Thr Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser 
    1810                1815                1820                

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
1825                1830                1835                1840

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Thr Ser Ala Ser 
                1845                1850                1855    

Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
            1860                1865                1870        

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
        1875                1880                1885            

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
    1890                1895                1900                

Val Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
1905                1910                1915                1920

Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser 
                1925                1930                1935    

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
            1940                1945                1950        

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
        1955                1960                1965            

Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser 
    1970                1975                1980                

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
1985                1990                1995                2000

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
                2005                2010                2015    

Ala Ser Ala Ser Ile Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser 
            2020                2025                2030        

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
        2035                2040                2045            

Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser 
    2050                2055                2060                

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
2065                2070                2075                2080

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
                2085                2090                2095    

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
            2100                2105                2110        

Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
        2115                2120                2125            

Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
    2130                2135                2140                

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
2145                2150                2155                2160

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
                2165                2170                2175    

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser 
            2180                2185                2190        

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
        2195                2200                2205            

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser 
    2210                2215                2220                

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
2225                2230                2235                2240

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
                2245                2250                2255    

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Ile Ser Ala Ser Glu Ser 
            2260                2265                2270        

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Val Ser 
        2275                2280                2285            

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser 
    2290                2295                2300                

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser 
2305                2310                2315                2320

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
                2325                2330                2335    

Ala Ser Ile Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser 
            2340                2345                2350        

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
        2355                2360                2365            

Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Thr Ser Ala Ser 
    2370                2375                2380                

Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser 
2385                2390                2395                2400

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
                2405                2410                2415    

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
            2420                2425                2430        

Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
        2435                2440                2445            

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
    2450                2455                2460                

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
2465                2470                2475                2480

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
                2485                2490                2495    

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
            2500                2505                2510        

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
        2515                2520                2525            

Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
    2530                2535                2540                

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
2545                2550                2555                2560

Thr Ser Ala Ser Val Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser 
                2565                2570                2575    

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
            2580                2585                2590        

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser 
        2595                2600                2605            

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
    2610                2615                2620                

Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
2625                2630                2635                2640

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
                2645                2650                2655    

Thr Ser Ala Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
            2660                2665                2670        

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
        2675                2680                2685            

Ala Ser Ile Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser 
    2690                2695                2700                

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
2705                2710                2715                2720

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Ile Ser Ala Ser 
                2725                2730                2735    

Glu Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Thr Ser 
            2740                2745                2750        

Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser 
        2755                2760                2765            

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
    2770                2775                2780                

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser 
2785                2790                2795                2800

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
                2805                2810                2815    

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
            2820                2825                2830        

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Val Ser 
        2835                2840                2845            

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
    2850                2855                2860                

Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser 
2865                2870                2875                2880

Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
                2885                2890                2895    

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
            2900                2905                2910        

Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
        2915                2920                2925            

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser 
    2930                2935                2940                

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
2945                2950                2955                2960

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser 
                2965                2970                2975    

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser 
            2980                2985                2990        

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
        2995                3000                3005            

Thr Ser Ala Ser Gly Ser Ala Ser Thr Ser Thr Ser Ala Ser Ala Ser 
    3010                3015                3020                

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
3025                3030                3035                3040

Ile Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser 
                3045                3050                3055    

Thr Ser Thr Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser 
            3060                3065                3070        

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
        3075                3080                3085            

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Thr Ser 
    3090                3095                3100                

Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
3105                3110                3115                3120

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
                3125                3130                3135    

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Val Ser Ala Ser Thr Ser 
            3140                3145                3150        

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
        3155                3160                3165            

Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
    3170                3175                3180                

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
3185                3190                3195                3200

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
                3205                3210                3215    

Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
            3220                3225                3230        

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
        3235                3240                3245            

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Ile Ser 
    3250                3255                3260                

Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
3265                3270                3275                3280

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
                3285                3290                3295    

Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
            3300                3305                3310        

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
        3315                3320                3325            

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
    3330                3335                3340                

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser 
3345                3350                3355                3360

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser 
                3365                3370                3375    

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
            3380                3385                3390        

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
        3395                3400                3405            

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
    3410                3415                3420                

Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser 
3425                3430                3435                3440

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
                3445                3450                3455    

Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser 
            3460                3465                3470        

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
        3475                3480                3485            

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
    3490                3495                3500                

Ala Ser Ala Ser Ile Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser 
3505                3510                3515                3520

Ala Ser Ala Ser Thr Ser Ala Ser Val Ser Ala Ser Thr Ser Ala Ser 
                3525                3530                3535    

Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser 
            3540                3545                3550        

Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser 
        3555                3560                3565            

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Ile Ser Ala Ser 
    3570                3575                3580                

Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
3585                3590                3595                3600

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
                3605                3610                3615    

Glu Ser Ala Ser Thr Ser Thr Ser Ala Ser Ala Ser Thr Ser Ala Ser 
            3620                3625                3630        

Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
        3635                3640                3645            

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
    3650                3655                3660                

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser 
3665                3670                3675                3680

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
                3685                3690                3695    

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
            3700                3705                3710        

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
        3715                3720                3725            

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
    3730                3735                3740                

Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser 
3745                3750                3755                3760

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
                3765                3770                3775    

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Val Ser 
            3780                3785                3790        

Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser 
        3795                3800                3805            

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser 
    3810                3815                3820                

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser 
3825                3830                3835                3840

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
                3845                3850                3855    

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
            3860                3865                3870        

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
        3875                3880                3885            

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
    3890                3895                3900                

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
3905                3910                3915                3920

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
                3925                3930                3935    

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Ile Ser Ala Ser Glu Ser 
            3940                3945                3950        

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
        3955                3960                3965            

Ala Ser Thr Ser Ala Ser Val Ser Ala Ser Thr Ser Ala Ser Ala Ser 
    3970                3975                3980                

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Ile Ser Ala Ser Glu Ser 
3985                3990                3995                4000

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
                4005                4010                4015    

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
            4020                4025                4030        

Ala Ser Ile Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser 
        4035                4040                4045            

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
    4050                4055                4060                

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
4065                4070                4075                4080

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
                4085                4090                4095    

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
            4100                4105                4110        

Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser 
        4115                4120                4125            

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Ile Ser Ala Ser Glu Ser 
    4130                4135                4140                

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
4145                4150                4155                4160

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser 
                4165                4170                4175    

Ala Ser Thr Ser Thr Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser 
            4180                4185                4190        

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
        4195                4200                4205            

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
    4210                4215                4220                

Ala Ser Thr Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser 
4225                4230                4235                4240

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
                4245                4250                4255    

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
            4260                4265                4270        

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
        4275                4280                4285            

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
    4290                4295                4300                

Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
4305                4310                4315                4320

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
                4325                4330                4335    

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Val Ser Ala Ser 
            4340                4345                4350        

Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
        4355                4360                4365            

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser 
    4370                4375                4380                

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser 
4385                4390                4395                4400

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
                4405                4410                4415    

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
            4420                4425                4430        

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
        4435                4440                4445            

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
    4450                4455                4460                

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
4465                4470                4475                4480

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
                4485                4490                4495    

Thr Ser Ala Ser Ala Ser Ala Ser Ile Ser Ala Ser Glu Ser Ala Ser 
            4500                4505                4510        

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
        4515                4520                4525            

Thr Ser Ala Ser Val Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
    4530                4535                4540                

Thr Ser Ala Ser Ala Ser Ala Ser Ile Ser Ala Ser Glu Ser Ala Ser 
4545                4550                4555                4560

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
                4565                4570                4575    

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
            4580                4585                4590        

Ile Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
        4595                4600                4605            

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
    4610                4615                4620                

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
4625                4630                4635                4640

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
                4645                4650                4655    

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
            4660                4665                4670        

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
        4675                4680                4685            

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
    4690                4695                4700                

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Val Ser Asn Ser Ala Asn 
4705                4710                4715                4720

His Ser Asn Ser Gln Val Gly Asn Thr Ser Gly Ser Thr Gly Lys Ser 
                4725                4730                4735    

Gln Lys Glu Leu Pro Asn Thr Gly Thr Glu Ser Ser Ile Gly Ser Val 
            4740                4745                4750        

Leu Leu Gly Val Leu Ala Ala Val Thr Gly Ile Gly Leu Val Ala Lys 
        4755                4760                4765            

Arg Arg Lys Arg Asp Glu Glu Glu 
    4770                4775    

<210>   98
<211>   202
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   98
Met Ser Asn Glu Lys Asn Thr Asn Thr Asn Val Glu Lys Lys Asp Ala 
1               5                   10                  15      

Thr Val Val Ala His Glu Ile Lys Gly Glu Leu Thr Tyr Glu Asp Lys 
            20                  25                  30          

Val Ile Gln Lys Ile Ile Gly Leu Ser Leu Glu Asn Val Ser Gly Leu 
        35                  40                  45              

Leu Gly Ile Asp Gly Gly Phe Phe Ser Asn Leu Lys Glu Lys Ile Val 
    50                  55                  60                  

Asn Ser Asp Asp Val Thr Ser Gly Val Asn Val Glu Val Gly Lys Thr 
65                  70                  75                  80  

Gln Val Ala Val Asp Leu Asn Val Ile Val Glu Tyr Gln Lys Asn Val 
                85                  90                  95      

Pro Ala Leu Tyr Ser Glu Ile Arg Glu Ile Val Ser Ser Glu Val Ala 
            100                 105                 110         

Lys Met Thr Asp Leu Glu Ile Val Glu Ile Asn Val Asn Val Val Asp 
        115                 120                 125             

Ile Lys Thr Lys Glu Gln His Glu Ala Asp Ser Val Ser Leu Gln Asp 
    130                 135                 140                 

Arg Val Ser Asp Val Ala Glu Ser Thr Gly Glu Phe Thr Ser Glu Gln 
145                 150                 155                 160 

Phe Glu Lys Ala Lys Ser Gly Leu Gly Ser Gly Phe Ser Thr Val Gln 
                165                 170                 175     

Glu Lys Val Ser Glu Gly Val Glu Ala Val Lys Gly Ala Ala Asn Gly 
            180                 185                 190         

Val Val Ser His Glu Asn Thr Arg Val Asn 
        195                 200         

<210>   99
<211>   355
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   99
Met Thr Lys Glu Lys Asn Val Ile Leu Thr Ala Arg Asp Ile Val Val 
1               5                   10                  15      

Glu Phe Asp Val Arg Asp Lys Val Leu Thr Ala Ile Arg Gly Val Ser 
            20                  25                  30          

Leu Glu Leu Val Glu Gly Glu Val Leu Ala Leu Val Gly Glu Ser Gly 
        35                  40                  45              

Ser Gly Lys Ser Val Leu Thr Lys Thr Phe Thr Gly Met Leu Glu Glu 
    50                  55                  60                  

Asn Gly Arg Ile Ala Gln Gly Ser Ile Asp Tyr Arg Gly Gln Asp Leu 
65                  70                  75                  80  

Thr Ala Leu Ser Ser His Lys Asp Trp Glu Gln Ile Arg Gly Ala Lys 
                85                  90                  95      

Ile Ala Thr Ile Phe Gln Asp Pro Met Thr Ser Leu Asp Pro Ile Lys 
            100                 105                 110         

Thr Ile Gly Ser Gln Ile Thr Glu Val Ile Val Lys His Gln Gly Lys 
        115                 120                 125             

Thr Ala Lys Glu Ala Lys Glu Leu Ala Ile Asp Tyr Met Asn Lys Val 
    130                 135                 140                 

Gly Ile Pro Asp Ala Asp Arg Arg Phe Asn Glu Tyr Pro Phe Gln Tyr 
145                 150                 155                 160 

Ser Gly Gly Met Arg Gln Arg Ile Val Ile Ala Ile Ala Leu Ala Cys 
                165                 170                 175     

Arg Pro Asp Val Leu Ile Cys Asp Glu Pro Thr Thr Ala Leu Asp Val 
            180                 185                 190         

Thr Ile Gln Ala Gln Ile Ile Asp Leu Leu Lys Ser Leu Gln Asn Glu 
        195                 200                 205             

Tyr His Phe Thr Thr Ile Phe Ile Thr His Asp Leu Gly Val Val Ala 
    210                 215                 220                 

Ser Ile Ala Asp Lys Val Ala Val Met Tyr Ala Gly Glu Ile Val Glu 
225                 230                 235                 240 

Tyr Gly Thr Val Glu Glu Val Phe Tyr Asp Pro Arg His Pro Tyr Thr 
                245                 250                 255     

Trp Ser Leu Leu Ser Ser Leu Pro Gln Leu Ala Asp Asp Lys Gly Asp 
            260                 265                 270         

Leu Tyr Ser Ile Pro Gly Thr Pro Pro Ser Leu Tyr Thr Asp Leu Lys 
        275                 280                 285             

Gly Asp Ala Phe Ala Leu Arg Ser Asp Tyr Ala Met Gln Ile Asp Phe 
    290                 295                 300                 

Glu Gln Lys Ala Pro Gln Phe Ser Val Ser Glu Thr His Trp Ala Lys 
305                 310                 315                 320 

Thr Trp Leu Leu His Glu Asp Ala Pro Lys Val Glu Lys Pro Ala Val 
                325                 330                 335     

Ile Ala Asn Leu His Asp Lys Ile Arg Glu Lys Met Gly Phe Ala His 
            340                 345                 350         

Leu Ala Asp 
        355 

<210>   100
<211>   659
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   100
Met Lys Lys Asn Arg Val Phe Ala Thr Ala Gly Leu Val Leu Leu Ala 
1               5                   10                  15      

Ala Gly Val Leu Ala Ala Cys Ser Ser Ser Lys Ser Ser Asp Ser Ser 
            20                  25                  30          

Ala Pro Lys Ala Tyr Gly Tyr Val Tyr Thr Ala Asp Pro Glu Thr Leu 
        35                  40                  45              

Asp Tyr Leu Ile Ser Ser Lys Asn Ser Thr Thr Val Val Thr Ser Asn 
    50                  55                  60                  

Gly Ile Asp Gly Leu Phe Thr Asn Asp Asn Tyr Gly Asn Leu Ala Pro 
65                  70                  75                  80  

Ala Val Ala Glu Asp Trp Glu Val Ser Lys Asp Gly Leu Thr Tyr Thr 
                85                  90                  95      

Tyr Lys Ile Arg Lys Gly Val Lys Trp Phe Thr Ser Asp Gly Glu Glu 
            100                 105                 110         

Tyr Ala Glu Val Thr Ala Lys Asp Phe Val Asn Gly Leu Lys His Ala 
        115                 120                 125             

Ala Asp Lys Lys Ser Glu Ala Met Tyr Leu Ala Glu Asn Ser Val Lys 
    130                 135                 140                 

Gly Leu Ala Asp Tyr Leu Ser Gly Thr Ser Thr Asp Phe Ser Thr Val 
145                 150                 155                 160 

Gly Val Lys Ala Val Asp Asp Tyr Thr Leu Gln Tyr Thr Leu Asn Gln 
                165                 170                 175     

Pro Glu Pro Phe Trp Asn Ser Lys Leu Thr Tyr Ser Ile Phe Trp Pro 
            180                 185                 190         

Leu Asn Glu Glu Phe Glu Thr Ser Lys Gly Ser Asp Phe Ala Lys Pro 
        195                 200                 205             

Thr Asp Pro Thr Ser Leu Leu Tyr Asn Gly Pro Phe Leu Leu Lys Gly 
    210                 215                 220                 

Leu Thr Ala Lys Ser Ser Val Glu Phe Val Lys Asn Glu Gln Tyr Trp 
225                 230                 235                 240 

Asp Lys Glu Asn Val His Leu Asp Thr Ile Asn Leu Ala Tyr Tyr Asp 
                245                 250                 255     

Gly Ser Asp Gln Glu Ser Leu Glu Arg Asn Phe Thr Ser Gly Ala Tyr 
            260                 265                 270         

Ser Tyr Ala Arg Leu Tyr Pro Thr Ser Ser Asn Tyr Ser Lys Val Ala 
        275                 280                 285             

Glu Glu Tyr Lys Asp Asn Ile Tyr Tyr Thr Gln Ser Gly Ser Gly Ile 
    290                 295                 300                 

Ala Gly Leu Gly Val Asn Ile Asp Arg Gln Ser Tyr Asn Tyr Thr Ser 
305                 310                 315                 320 

Lys Thr Thr Asp Ser Glu Lys Val Ala Thr Lys Lys Ala Leu Leu Asn 
                325                 330                 335     

Lys Asp Phe Arg Gln Ala Leu Asn Phe Ala Leu Asp Arg Ser Ala Tyr 
            340                 345                 350         

Ser Ala Gln Ile Asn Gly Lys Asp Gly Ala Ala Leu Ala Val Arg Asn 
        355                 360                 365             

Leu Phe Val Lys Pro Asp Phe Val Ser Ala Gly Glu Lys Thr Phe Gly 
    370                 375                 380                 

Asp Leu Val Ala Ala Gln Leu Pro Ala Tyr Gly Asp Glu Trp Lys Gly 
385                 390                 395                 400 

Val Asn Leu Ala Asp Gly Gln Asp Gly Leu Phe Asn Ala Asp Lys Ala 
                405                 410                 415     

Lys Ala Glu Phe Ala Lys Ala Lys Lys Ala Leu Glu Ala Asp Gly Val 
            420                 425                 430         

Gln Phe Pro Ile His Leu Asp Val Pro Val Asp Gln Ala Ser Lys Asn 
        435                 440                 445             

Tyr Ile Ser Arg Ile Gln Ser Phe Lys Gln Ser Val Glu Thr Val Leu 
    450                 455                 460                 

Gly Val Glu Asn Val Val Val Asp Ile Gln Gln Met Thr Ser Asp Glu 
465                 470                 475                 480 

Phe Leu Asn Ile Thr Tyr Tyr Ala Ala Asn Ala Ser Ser Glu Asp Trp 
                485                 490                 495     

Asp Val Ser Gly Gly Val Ser Trp Gly Pro Asp Tyr Gln Asp Pro Ser 
            500                 505                 510         

Thr Tyr Leu Asp Ile Leu Lys Thr Thr Ser Ser Glu Thr Thr Lys Thr 
        515                 520                 525             

Tyr Leu Gly Phe Asp Asn Pro Asn Ser Pro Ser Val Val Gln Val Gly 
    530                 535                 540                 

Leu Lys Glu Tyr Asp Lys Leu Val Asp Glu Ala Ala Arg Glu Thr Ser 
545                 550                 555                 560 

Asp Leu Asn Val Arg Tyr Glu Lys Tyr Ala Ala Ala Gln Ala Trp Leu 
                565                 570                 575     

Thr Asp Ser Ser Leu Phe Ile Pro Ala Met Ala Ser Ser Gly Ala Ala 
            580                 585                 590         

Pro Val Leu Ser Arg Ile Val Pro Phe Thr Gly Ala Ser Ala Gln Thr 
        595                 600                 605             

Gly Ser Lys Gly Ser Asp Val Tyr Phe Lys Tyr Leu Lys Ser Gln Asp 
    610                 615                 620                 

Lys Val Val Thr Lys Glu Glu Tyr Glu Lys Ala Arg Glu Lys Trp Leu 
625                 630                 635                 640 

Lys Glu Lys Ala Glu Ser Asn Glu Lys Ala Gln Lys Glu Leu Ala Ser 
                645                 650                 655     

His Val Lys 
            

<210>   101
<211>   467
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   101
Met Lys Lys Lys Tyr Trp Thr Leu Ala Ile Leu Phe Phe Cys Leu Phe 
1               5                   10                  15      

Asn Asn Ser Val Thr Ala Gln Glu Ile Pro Lys Asn Leu Asp Gly Asn 
            20                  25                  30          

Ile Thr His Thr Gln Thr Ser Glu Ser Phe Ser Glu Ser Asp Glu Lys 
        35                  40                  45              

Gln Val Asp Tyr Ser Asn Lys Asn Gln Glu Glu Val Asp Gln Asn Lys 
    50                  55                  60                  

Phe Arg Ile Gln Ile Asp Lys Thr Glu Leu Phe Val Thr Thr Asp Lys 
65                  70                  75                  80  

His Leu Glu Lys Asn Cys Cys Lys Leu Glu Leu Glu Pro Gln Ile Asn 
                85                  90                  95      

Asn Asp Ile Val Asn Ser Glu Ser Asn Asn Leu Leu Gly Glu Asp Asn 
            100                 105                 110         

Leu Asp Asn Lys Ile Lys Glu Asn Val Ser His Leu Asp Asn Arg Gly 
        115                 120                 125             

Gly Asn Ile Glu His Asp Lys Asp Asn Leu Glu Ser Ser Ile Val Arg 
    130                 135                 140                 

Lys Tyr Glu Trp Asp Ile Asp Lys Val Thr Gly Gly Gly Glu Ser Tyr 
145                 150                 155                 160 

Lys Leu Tyr Ser Lys Ser Asn Ser Lys Val Ser Ile Ala Ile Leu Asp 
                165                 170                 175     

Ser Gly Val Asp Leu Gln Asn Thr Gly Leu Leu Lys Asn Leu Ser Asn 
            180                 185                 190         

His Ser Lys Asn Tyr Val Pro Asn Lys Gly Tyr Leu Gly Lys Glu Glu 
        195                 200                 205             

Gly Glu Glu Gly Ile Ile Ser Asp Ile Gln Asp Arg Leu Gly His Gly 
    210                 215                 220                 

Thr Ala Val Val Ala Gln Ile Val Gly Asp Asp Asn Ile Asn Gly Val 
225                 230                 235                 240 

Asn Pro His Val Asn Ile Asn Val Tyr Arg Ile Phe Gly Lys Ser Ser 
                245                 250                 255     

Ala Ser Pro Asp Trp Ile Val Lys Ala Ile Phe Asp Ala Val Asp Asp 
            260                 265                 270         

Gly Asn Asp Ile Ile Asn Leu Ser Thr Gly Gln Tyr Leu Met Ile Asp 
        275                 280                 285             

Gly Glu Tyr Glu Asp Gly Thr Asn Asp Phe Glu Thr Phe Leu Lys Tyr 
    290                 295                 300                 

Lys Lys Ala Ile Asp Tyr Ala Asn Gln Lys Gly Val Ile Ile Val Ala 
305                 310                 315                 320 

Ala Leu Gly Asn Asp Ser Leu Asn Val Ser Asn Gln Ser Asp Leu Leu 
                325                 330                 335     

Lys Leu Ile Ser Ser Arg Lys Lys Val Arg Lys Pro Gly Leu Val Val 
            340                 345                 350         

Asp Val Pro Ser Tyr Phe Ser Ser Thr Ile Ser Val Gly Gly Ile Asp 
        355                 360                 365             

Arg Leu Gly Asn Leu Ser Asp Phe Ser Asn Lys Gly Asp Ser Asp Ala 
    370                 375                 380                 

Ile Tyr Ala Pro Ala Gly Ser Thr Leu Ser Leu Ser Glu Leu Gly Leu 
385                 390                 395                 400 

Asn Asn Phe Ile Asn Ala Glu Lys Tyr Lys Glu Asp Trp Ile Phe Ser 
                405                 410                 415     

Ala Thr Leu Gly Gly Tyr Thr Tyr Leu Tyr Gly Asn Ser Phe Ala Ala 
            420                 425                 430         

Pro Lys Val Ser Gly Ala Ile Ala Met Ile Ile Asp Lys Tyr Lys Leu 
        435                 440                 445             

Lys Asp Gln Pro Tyr Asn Tyr Met Phe Val Lys Lys Phe Trp Lys Lys 
    450                 455                 460                 

His Tyr Gln 
465         

<210>   102
<211>   308
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   102
Met Lys Lys Asp Glu Leu Phe Glu Gly Phe Tyr Leu Ile Lys Ser Ala 
1               5                   10                  15      

Asp Leu Arg Gln Thr Arg Ala Gly Lys Asn Tyr Leu Ala Phe Thr Phe 
            20                  25                  30          

Gln Asp Asp Ser Gly Glu Ile Asp Gly Lys Leu Trp Asp Ala Gln Pro 
        35                  40                  45              

His Asn Ile Glu Ala Phe Thr Ala Gly Lys Val Val His Met Lys Gly 
    50                  55                  60                  

Arg Arg Glu Val Tyr Asn Asn Thr Pro Gln Val Asn Gln Ile Thr Leu 
65                  70                  75                  80  

Arg Leu Pro Gln Ala Gly Glu Pro Asn Asp Pro Ala Asp Phe Lys Val 
                85                  90                  95      

Lys Ser Pro Val Asp Val Lys Glu Ile Arg Asp Tyr Met Ser Gln Met 
            100                 105                 110         

Ile Phe Lys Ile Glu Asn Pro Val Trp Gln Arg Ile Val Arg Asn Leu 
        115                 120                 125             

Tyr Thr Lys Tyr Asp Lys Glu Phe Tyr Ser Tyr Pro Ala Ala Lys Thr 
    130                 135                 140                 

Asn His His Ala Phe Glu Thr Gly Leu Ala Tyr His Thr Ala Thr Met 
145                 150                 155                 160 

Val Arg Leu Ala Asp Ala Ile Ser Glu Val Tyr Pro Gln Leu Asn Lys 
                165                 170                 175     

Ser Leu Leu Tyr Ala Gly Ile Met Leu His Asp Leu Ala Lys Val Ile 
            180                 185                 190         

Glu Leu Thr Gly Pro Asp Gln Thr Glu Tyr Thr Val Arg Gly Asn Leu 
        195                 200                 205             

Leu Gly His Ile Ala Leu Ile Asp Ser Glu Ile Thr Lys Thr Val Met 
    210                 215                 220                 

Glu Leu Gly Ile Asp Asp Thr Lys Glu Glu Val Val Leu Leu Arg His 
225                 230                 235                 240 

Val Ile Leu Ser His His Gly Leu Leu Glu Tyr Gly Ser Pro Val Arg 
                245                 250                 255     

Pro Arg Ile Met Glu Ala Glu Ile Ile His Met Ile Asp Asn Leu Asp 
            260                 265                 270         

Ala Ser Met Met Met Met Ser Thr Ala Leu Ala Leu Val Asp Lys Gly 
        275                 280                 285             

Glu Met Thr Asn Lys Ile Phe Ala Met Asp Asn Arg Ser Phe Tyr Lys 
    290                 295                 300                 

Pro Asp Leu Asp 
305             

<210>   103
<211>   221
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   103
Val Thr Ile Leu Gly Lys Asp Thr Val Gln Gln Ser Ala Lys Gly Glu 
1               5                   10                  15      

Ser Val Thr Gln Glu Ala Thr Pro Glu Tyr Lys Leu Glu Asn Thr Pro 
            20                  25                  30          

Gly Gly Asp Lys Gly Gly Asn Thr Gly Ser Ser Asp Ala Asn Ala Asn 
        35                  40                  45              

Glu Gly Gly Gly Ser Gln Ala Gly Gly Ser Ala His Thr Gly Ser Gln 
    50                  55                  60                  

Asn Ser Ala Gln Ser Gln Ala Ser Lys Gln Leu Ala Thr Glu Lys Glu 
65                  70                  75                  80  

Ser Ala Lys Asn Ala Ile Glu Lys Ala Ala Lys Asp Lys Gln Asp Glu 
                85                  90                  95      

Ile Lys Gly Ala Pro Leu Ser Asp Lys Glu Lys Ala Glu Leu Leu Ala 
            100                 105                 110         

Arg Val Glu Ala Glu Lys Gln Ala Ala Leu Lys Glu Ile Glu Asn Ala 
        115                 120                 125             

Lys Thr Met Glu Asp Val Lys Glu Ala Glu Thr Ile Gly Val Gln Ala 
    130                 135                 140                 

Ile Ala Met Val Thr Val Pro Lys Arg Pro Val Ala Pro Asn Ala Ala 
145                 150                 155                 160 

Pro Lys Thr Thr Ser Ala Pro Gln Ala Thr Ala Gly Thr Met Gln Asp 
                165                 170                 175     

Val Thr Tyr Gln Ser Pro Ala Gly Lys Gln Leu Pro Asn Thr Gly Ser 
            180                 185                 190         

Ala Ser Ser Ala Ala Leu Ala Ser Leu Gly Leu Val Val Ala Thr Ser 
        195                 200                 205             

Gly Phe Ala Leu Leu Gly Arg Lys Thr Arg Arg Arg Lys 
    210                 215                 220     

<210>   104
<211>   336
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   104
Met Asn Ala Asp Asp Thr Val Thr Ile Tyr Asp Val Ala Arg Glu Ala 
1               5                   10                  15      

Gly Val Ser Met Ala Thr Val Ser Arg Val Val Asn Gly Asn Lys Asn 
            20                  25                  30          

Val Lys Glu Asn Thr Arg Lys Lys Val Leu Glu Val Ile Asp Arg Leu 
        35                  40                  45              

Asp Tyr Arg Pro Asn Ala Val Ala Arg Gly Leu Ala Ser Lys Lys Thr 
    50                  55                  60                  

Thr Thr Val Gly Val Val Ile Pro Asn Ile Thr Asn Gly Tyr Phe Ser 
65                  70                  75                  80  

Ser Leu Ala Lys Gly Ile Asp Asp Ile Ala Glu Met Tyr Lys Tyr Asn 
                85                  90                  95      

Ile Val Leu Ala Asn Ser Asp Glu Asp Asn Glu Lys Glu Val Ser Val 
            100                 105                 110         

Val Asn Thr Leu Phe Ser Lys Gln Val Asp Gly Ile Ile Tyr Met Gly 
        115                 120                 125             

Tyr His Leu Thr Asp Lys Ile Arg Ser Glu Phe Ser Arg Ser Arg Thr 
    130                 135                 140                 

Pro Ile Val Leu Ala Gly Thr Val Asp Val Glu His Gln Leu Pro Ser 
145                 150                 155                 160 

Val Asn Ile Asp Tyr Lys Gln Ala Thr Ile Asp Ala Val Ser Tyr Leu 
                165                 170                 175     

Ala Lys Glu Asn Glu Arg Ile Ala Phe Val Ser Gly Pro Leu Val Asp 
            180                 185                 190         

Asp Ile Asn Gly Lys Val Arg Leu Val Gly Tyr Lys Glu Thr Leu Lys 
        195                 200                 205             

Lys Ala Gly Ile Thr Tyr Ser Glu Gly Leu Val Phe Glu Ser Lys Tyr 
    210                 215                 220                 

Ser Tyr Asp Asp Gly Tyr Ala Leu Ala Glu Arg Leu Ile Ser Ser Asn 
225                 230                 235                 240 

Ala Thr Ala Ala Val Val Thr Gly Asp Glu Leu Ala Ala Gly Val Leu 
                245                 250                 255     

Asn Gly Leu Ala Asp Lys Gly Val Ser Val Pro Glu Asp Phe Glu Ile 
            260                 265                 270         

Ile Thr Ser Asp Asp Ser Gln Ile Ser Arg Phe Thr Arg Pro Asn Leu 
        275                 280                 285             

Thr Thr Ile Ala Gln Pro Leu Tyr Asp Leu Gly Ala Ile Ser Met Arg 
    290                 295                 300                 

Met Leu Thr Lys Ile Met His Lys Glu Glu Leu Glu Glu Arg Glu Val 
305                 310                 315                 320 

Leu Leu Pro His Gly Leu Thr Glu Arg Ser Ser Thr Arg Lys Arg Lys 
                325                 330                 335     


<210>   105
<211>   469
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   105
Met Lys Lys Lys Leu Val Phe Pro Asn Leu Phe Trp Trp Gly Ala Ala 
1               5                   10                  15      

Ser Ser Gly Pro Gln Thr Glu Gly Gln Tyr Gly Lys Val His Glu Asn 
            20                  25                  30          

Val Met Asp Tyr Trp Phe Lys Thr His Pro Glu Asp Phe Phe Asp Asn 
        35                  40                  45              

Val Gly Pro Leu Val Ala Ser Asn Phe Phe His Thr Tyr Thr Glu Asp 
    50                  55                  60                  

Phe His Leu Met Lys Glu Ile Gly Val Asn Ser Phe Arg Thr Ser Ile 
65                  70                  75                  80  

Gln Trp Ser Arg Leu Ile Lys Asn Leu Glu Thr Gly Glu Pro Asp Pro 
                85                  90                  95      

Lys Gly Ile Ala Phe Tyr Asn Ala Ile Ile Glu Glu Ala Lys Lys Asn 
            100                 105                 110         

Gln Met Asp Leu Val Met Asn Leu His His Phe Asp Leu Pro Val Glu 
        115                 120                 125             

Leu Leu Gln Lys Tyr Gly Gly Trp Glu Ser Lys His Val Val Glu Leu 
    130                 135                 140                 

Phe Val Lys Phe Ala Lys Thr Ala Phe Thr Cys Phe Gly Asp Lys Val 
145                 150                 155                 160 

His Tyr Trp Thr Thr Phe Asn Glu Pro Met Val Ile Pro Glu Ala Gly 
                165                 170                 175     

Tyr Leu Tyr Ala Phe His Tyr Pro Asn Leu Lys Gly Lys Gly Lys Glu 
            180                 185                 190         

Ala Val Gln Val Ile Tyr Asn Leu Asn Leu Ala Ser Ala Lys Val Ile 
        195                 200                 205             

Gln Leu Tyr Arg Ser Leu Glu Leu Asp Gly Lys Ile Gly Ile Ile Leu 
    210                 215                 220                 

Asn Leu Thr Pro Ala Tyr Pro Arg Ser Asn Ser Pro Glu Asp Leu Glu 
225                 230                 235                 240 

Ala Ser Arg Phe Thr Asp Asp Phe Phe Asn Lys Val Phe Leu Asn Pro 
                245                 250                 255     

Ala Val Lys Gly Thr Phe Pro Glu Arg Leu Val Lys Gln Leu Glu Arg 
            260                 265                 270         

Asp Gly Val Leu Trp Ser His Thr Glu Lys Glu Leu Gln Leu Met Lys 
        275                 280                 285             

Ser Asn Thr Val Asp Phe Leu Gly Val Asn Tyr Tyr His Pro Lys Arg 
    290                 295                 300                 

Val Gln Ala Gln Ala Asn Pro Glu Glu Tyr Gln Thr Pro Trp Met Pro 
305                 310                 315                 320 

Asp Gln Tyr Phe Lys Glu Tyr Glu Trp Leu Glu Arg Arg Met Asn Pro 
                325                 330                 335     

Tyr Arg Gly Trp Glu Ile Phe Pro Lys Ala Ile Tyr Asp Ile Ala Met 
            340                 345                 350         

Ile Val Lys Glu Glu Tyr Gly Asn Ile Pro Trp Phe Ile Ser Glu Asn 
        355                 360                 365             

Gly Met Gly Val Glu Asn Glu Ala Arg Phe Ile Asp Glu Asn Gly Val 
    370                 375                 380                 

Ile Asp Asp Val Tyr Arg Ile Glu Phe Tyr Glu Glu His Leu Arg Trp 
385                 390                 395                 400 

Leu His Lys Ala Ile Glu Glu Gly Ser His Cys Phe Gly Tyr His Ala 
                405                 410                 415     

Trp Thr Ala Phe Asp Cys Trp Ser Trp Asn Asn Ala Tyr Lys Asn Arg 
            420                 425                 430         

Tyr Gly Phe Ile Ser Val Asp Leu Glu Thr Gln Lys Arg Thr Ile Lys 
        435                 440                 445             

Ser Ser Gly Arg Trp Tyr Arg Lys Val Ser Asp Asn Asn Gly Phe Glu 
    450                 455                 460                 

Val Glu Ile Glu Glu 
465                 

<210>   106
<211>   136
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   106
Val Glu Asn Leu Thr Asn Phe Tyr Glu Lys Tyr Arg Val Tyr Leu Thr 
1               5                   10                  15      

Arg Pro Arg Leu Glu Leu Leu Ala Val Val Thr Ile Val Phe Cys Ala 
            20                  25                  30          

Val Leu Val Phe Phe Leu Asn Ile Pro Gly Lys Gly Val Leu Lys Leu 
        35                  40                  45              

Asp Asn Gly Thr Ile Val Tyr Asp Gly Ser Leu Val Arg Gly Lys Met 
    50                  55                  60                  

Asn Gly Gln Gly Thr Ile Thr Phe Gln Asn Gly Asp Gln Tyr Thr Gly 
65                  70                  75                  80  

Gly Phe Asn Asn Gly Ala Phe Asn Gly Lys Gly Thr Phe Gln Ser Lys 
                85                  90                  95      

Glu Gly Trp Thr Tyr Glu Gly Asp Phe Val Asn Gly Gln Ala Glu Gly 
            100                 105                 110         

Lys Gly Lys Leu Thr Thr Glu Gln Glu Val Val Tyr Glu Gly Thr Phe 
        115                 120                 125             

Lys Gln Gly Val Phe Gln Gln Lys 
    130                 135     

<210>   107
<211>   207
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   107
Met Leu Asn Lys Ile Arg Asp Tyr Leu Asp Phe Ala Gly Leu Gln Tyr 
1               5                   10                  15      

Arg Asn Pro Asp Lys Ala Gly Ala Glu Arg Glu Lys Met Leu Ala Phe 
            20                  25                  30          

Arg His Lys Gly Gln Glu Ala Arg Lys Val Phe Thr Glu Leu Ala Lys 
        35                  40                  45              

Ala Phe Gln Ala Ser His Pro Glu Trp Gln Leu Gln Gln Thr Ser Gln 
    50                  55                  60                  

Trp Met Asn Gln Ala Gln Arg Leu Arg Pro His Phe Trp Val Tyr Leu 
65                  70                  75                  80  

Gln Arg Asp Gly Gln Val Thr Glu Pro Met Met Ala Leu Arg Leu Tyr 
                85                  90                  95      

Gly Thr Ser Thr Asp Phe Gly Ile Ser Leu Glu Val Ser Phe Ile Glu 
            100                 105                 110         

Arg Lys Lys Asp Glu Gln Thr Leu Gly Lys Gln Ala Lys Val Leu Asp 
        115                 120                 125             

Ile Pro Thr Val Lys Gly Ile Tyr Tyr Leu Thr Tyr Ser Asn Gly Gln 
    130                 135                 140                 

Ser Gln Arg Trp Glu Ala Asn Glu Glu Lys Arg Arg Thr Leu Arg Glu 
145                 150                 155                 160 

Lys Val Arg Ser Gln Glu Val Arg Lys Val Leu Val Lys Val Asp Val 
                165                 170                 175     

Pro Met Thr Glu Asn Ser Ser Glu Glu Glu Ile Val Glu Gly Leu Leu 
            180                 185                 190         

Lys Ser Tyr Ser Lys Ile Leu Pro Tyr Tyr Leu Ala Thr Arg Lys 
        195                 200                 205         

<210>   108
<211>   152
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   108
Met Val Gln Asn Ser Cys Trp Gln Ser Lys Ser His Lys Val Lys Ala 
1               5                   10                  15      

Phe Thr Leu Leu Glu Ser Leu Leu Ala Leu Ile Val Ile Ser Gly Gly 
            20                  25                  30          

Leu Leu Leu Phe Gln Ala Met Ser Gln Leu Leu Ile Ser Glu Val Arg 
        35                  40                  45              

Tyr Gln Gln Gln Ser Glu Gln Lys Glu Trp Leu Leu Phe Val Asp Gln 
    50                  55                  60                  

Leu Glu Val Glu Leu Asp Arg Ser Gln Phe Glu Lys Val Glu Gly Asn 
65                  70                  75                  80  

Arg Leu Tyr Met Lys Gln Asp Gly Lys Asp Ile Ala Ile Gly Lys Ser 
                85                  90                  95      

Lys Ser Asp Asp Phe Arg Lys Thr Asn Ala Arg Gly Arg Gly Tyr Gln 
            100                 105                 110         

Pro Met Val Tyr Gly Leu Lys Ser Val Arg Ile Thr Glu Asp Asn Gln 
        115                 120                 125             

Leu Val Arg Phe His Phe Gln Phe Gln Lys Gly Leu Glu Arg Glu Phe 
    130                 135                 140                 

Ile Tyr Arg Val Glu Lys Glu Lys 
145                 150         

<210>   109
<211>   108
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   109
Met Lys Lys Met Met Thr Phe Leu Lys Lys Ala Lys Val Lys Ala Phe 
1               5                   10                  15      

Thr Leu Val Glu Met Leu Val Val Leu Leu Ile Ile Ser Val Leu Phe 
            20                  25                  30          

Leu Leu Phe Val Pro Asn Leu Thr Lys Gln Lys Glu Ala Val Asn Asp 
        35                  40                  45              

Lys Gly Lys Ala Ala Val Val Lys Val Val Glu Ser Gln Ala Glu Leu 
    50                  55                  60                  

Tyr Ser Leu Glu Lys Asn Glu Asp Ala Ser Leu Arg Lys Leu Gln Ala 
65                  70                  75                  80  

Asp Gly Arg Ile Thr Glu Glu Gln Ala Lys Ala Tyr Lys Glu Tyr Asn 
                85                  90                  95      

Asp Lys Asn Gly Gly Ala Asn Arg Lys Val Asn Asp 
            100                 105             

<210>   110
<211>   299
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   110
Met Thr Ser Lys Val Arg Lys Ala Val Ile Pro Ala Ala Gly Leu Gly 
1               5                   10                  15      

Thr Arg Phe Leu Pro Ala Thr Lys Ala Leu Ala Lys Glu Met Leu Pro 
            20                  25                  30          

Ile Val Asp Lys Pro Thr Ile Gln Phe Ile Val Glu Glu Ala Leu Lys 
        35                  40                  45              

Ser Gly Ile Glu Asp Ile Leu Val Val Thr Gly Lys Ser Lys Arg Ser 
    50                  55                  60                  

Ile Glu Asp His Phe Asp Ser Asn Phe Glu Leu Glu Tyr Asn Leu Lys 
65                  70                  75                  80  

Glu Lys Gly Lys Thr Asp Leu Leu Lys Leu Val Asp Lys Thr Thr Asp 
                85                  90                  95      

Met Arg Leu His Phe Ile Arg Gln Thr His Pro Arg Gly Leu Gly Asp 
            100                 105                 110         

Ala Val Leu Gln Ala Lys Ala Phe Val Gly Asn Glu Pro Phe Val Val 
        115                 120                 125             

Met Leu Gly Asp Asp Leu Met Asp Ile Thr Asp Glu Lys Ala Val Pro 
    130                 135                 140                 

Leu Thr Lys Gln Leu Met Asp Asp Tyr Glu Arg Thr His Ala Ser Thr 
145                 150                 155                 160 

Ile Ala Val Met Pro Val Pro His Asp Glu Val Ser Ala Tyr Gly Val 
                165                 170                 175     

Ile Ala Pro Gln Gly Glu Gly Lys Asp Gly Leu Tyr Ser Val Glu Thr 
            180                 185                 190         

Phe Val Glu Lys Pro Ala Pro Glu Asp Ala Pro Ser Asp Leu Ala Ile 
        195                 200                 205             

Ile Gly Arg Tyr Leu Leu Thr Pro Glu Ile Phe Glu Ile Leu Glu Lys 
    210                 215                 220                 

Gln Ala Pro Gly Ala Gly Asn Glu Ile Gln Leu Thr Asp Ala Ile Asp 
225                 230                 235                 240 

Thr Leu Asn Lys Thr Gln Arg Val Phe Ala Arg Glu Phe Lys Gly Ala 
                245                 250                 255     

Arg Tyr Asp Val Gly Asp Lys Phe Gly Phe Met Lys Thr Ser Ile Asp 
            260                 265                 270         

Tyr Ala Leu Lys His Pro Gln Val Lys Asp Asp Leu Lys Asn Tyr Leu 
        275                 280                 285             

Ile Gln Leu Gly Lys Glu Leu Thr Glu Lys Glu 
    290                 295                 

<210>   111
<211>   821
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   111
Met Gln Asn Gln Leu Asn Glu Leu Lys Arg Lys Met Leu Glu Phe Phe 
1               5                   10                  15      

Gln Gln Lys Gln Lys Asn Lys Lys Ser Ala Arg Pro Gly Lys Lys Gly 
            20                  25                  30          

Ser Ser Thr Lys Lys Ser Lys Thr Leu Asp Lys Ser Val Ile Phe Pro 
        35                  40                  45              

Ala Ile Leu Leu Ser Ile Lys Ala Leu Phe Asn Leu Leu Phe Val Leu 
    50                  55                  60                  

Gly Phe Leu Gly Gly Met Leu Gly Ala Gly Ile Ala Leu Gly Tyr Gly 
65                  70                  75                  80  

Val Ala Leu Phe Asp Lys Val Arg Val Pro Gln Thr Glu Glu Leu Val 
                85                  90                  95      

Asn Gln Val Lys Asp Ile Ser Ser Ile Ser Glu Ile Thr Tyr Ser Asp 
            100                 105                 110         

Gly Thr Val Ile Ala Ser Ile Glu Ser Asp Leu Leu Arg Thr Ser Ile 
        115                 120                 125             

Ser Ser Glu Gln Ile Ser Glu Asn Leu Lys Lys Ala Ile Ile Ala Thr 
    130                 135                 140                 

Glu Asp Glu His Phe Lys Glu His Lys Gly Val Val Pro Lys Ala Val 
145                 150                 155                 160 

Ile Arg Ala Thr Leu Gly Lys Phe Val Gly Leu Gly Ser Ser Ser Gly 
                165                 170                 175     

Gly Ser Thr Leu Thr Gln Gln Leu Ile Lys Gln Gln Val Val Gly Asp 
            180                 185                 190         

Ala Pro Thr Leu Ala Arg Lys Ala Ala Glu Ile Val Asp Ala Leu Ala 
        195                 200                 205             

Leu Glu Arg Ala Met Asn Lys Asp Glu Ile Leu Thr Thr Tyr Leu Asn 
    210                 215                 220                 

Val Ala Pro Phe Gly Arg Asn Asn Lys Gly Gln Asn Ile Ala Gly Ala 
225                 230                 235                 240 

Arg Gln Ala Ala Glu Gly Ile Phe Gly Val Asp Ala Ser Gln Leu Thr 
                245                 250                 255     

Val Pro Gln Ala Ala Phe Leu Ala Gly Leu Pro Gln Ser Pro Ile Thr 
            260                 265                 270         

Tyr Ser Pro Tyr Glu Asn Thr Gly Glu Leu Lys Ser Asp Glu Asp Leu 
        275                 280                 285             

Glu Ile Gly Leu Arg Arg Ala Lys Ala Val Leu Tyr Ser Met Tyr Arg 
    290                 295                 300                 

Thr Gly Ala Leu Ser Lys Asp Glu Tyr Ser Gln Tyr Lys Asp Tyr Asp 
305                 310                 315                 320 

Leu Lys Gln Asp Phe Leu Pro Ser Gly Thr Val Thr Gly Ile Ser Arg 
                325                 330                 335     

Asp Tyr Leu Tyr Phe Thr Thr Leu Ala Glu Ala Gln Glu Arg Met Tyr 
            340                 345                 350         

Asp Tyr Leu Ala Gln Arg Asp Asn Val Ser Ala Lys Glu Leu Lys Asn 
        355                 360                 365             

Glu Ala Thr Gln Lys Phe Tyr Arg Asp Leu Ala Ala Lys Glu Ile Glu 
    370                 375                 380                 

Asn Gly Gly Tyr Lys Ile Thr Thr Thr Ile Asp Gln Lys Ile His Ser 
385                 390                 395                 400 

Ala Met Gln Ser Ala Val Ala Asp Tyr Gly Tyr Leu Leu Asp Asp Gly 
                405                 410                 415     

Thr Gly Arg Val Glu Val Gly Asn Val Leu Met Asp Asn Gln Thr Gly 
            420                 425                 430         

Ala Ile Leu Gly Phe Val Gly Gly Arg Asn Tyr Gln Glu Asn Gln Asn 
        435                 440                 445             

Asn His Ala Phe Asp Thr Lys Arg Ser Pro Ala Ser Thr Thr Lys Pro 
    450                 455                 460                 

Leu Leu Ala Tyr Gly Ile Ala Ile Asp Gln Gly Leu Met Gly Ser Glu 
465                 470                 475                 480 

Thr Ile Leu Ser Asn Tyr Pro Thr Asn Phe Ala Asn Gly Asn Pro Ile 
                485                 490                 495     

Met Tyr Ala Asn Ser Lys Gly Thr Gly Met Met Thr Leu Gly Glu Ala 
            500                 505                 510         

Leu Asn Tyr Ser Trp Asn Ile Pro Ala Tyr Trp Thr Tyr Arg Met Leu 
        515                 520                 525             

Arg Glu Lys Gly Val Asp Val Lys Gly Tyr Met Glu Lys Met Gly Tyr 
    530                 535                 540                 

Glu Ile Pro Glu Tyr Gly Ile Glu Ser Leu Pro Met Gly Gly Gly Ile 
545                 550                 555                 560 

Glu Val Thr Val Ala Gln His Thr Asn Gly Tyr Gln Thr Leu Ala Asn 
                565                 570                 575     

Asn Gly Val Tyr His Gln Lys His Val Ile Ser Lys Ile Glu Ala Ala 
            580                 585                 590         

Asp Gly Arg Val Val Tyr Glu Tyr Gln Asp Lys Pro Val Gln Val Tyr 
        595                 600                 605             

Ser Lys Ala Thr Ala Thr Ile Met Gln Gly Leu Leu Arg Glu Val Leu 
    610                 615                 620                 

Ser Ser Arg Val Thr Thr Thr Phe Lys Ser Asn Leu Thr Ser Leu Asn 
625                 630                 635                 640 

Pro Thr Leu Ala Asn Ala Asp Trp Ile Gly Lys Thr Gly Thr Thr Asn 
                645                 650                 655     

Gln Asp Glu Asn Met Trp Leu Met Leu Ser Thr Pro Arg Leu Thr Leu 
            660                 665                 670         

Gly Gly Trp Ile Gly His Asp Asp Asn His Ser Leu Ser Arg Arg Ala 
        675                 680                 685             

Gly Tyr Ser Asn Asn Ser Asn Tyr Met Ala His Leu Val Asn Ala Ile 
    690                 695                 700                 

Gln Gln Ala Ser Pro Ser Ile Trp Gly Asn Glu Arg Phe Ala Leu Asp 
705                 710                 715                 720 

Pro Ser Val Val Lys Ser Glu Val Leu Lys Ser Thr Gly Gln Lys Pro 
                725                 730                 735     

Glu Lys Val Ser Val Glu Gly Lys Glu Val Glu Val Thr Gly Ser Thr 
            740                 745                 750         

Val Thr Ser Tyr Trp Ala Asn Lys Ser Gly Ala Pro Ala Thr Ser Tyr 
        755                 760                 765             

Arg Phe Ala Ile Gly Gly Ser Asp Ala Asp Tyr Gln Asn Ala Trp Ser 
    770                 775                 780                 

Ser Ile Val Gly Ser Leu Pro Thr Pro Ser Ser Ser Ser Ser Ser Ser 
785                 790                 795                 800 

Ser Ser Ser Ser Asp Ser Ser Asn Ser Ser Thr Thr Arg Pro Ser Ser 
                805                 810                 815     

Ser Arg Ala Arg Arg 
            820     

<210>   112
<211>   423
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   112
Met Ser Ser Lys Phe Met Lys Ser Ala Ala Val Leu Gly Thr Ala Thr 
1               5                   10                  15      

Leu Ala Ser Leu Leu Leu Val Ala Cys Gly Ser Lys Thr Ala Asp Lys 
            20                  25                  30          

Pro Ala Asp Ser Gly Ser Ser Glu Val Lys Glu Leu Thr Val Tyr Val 
        35                  40                  45              

Asp Glu Gly Tyr Lys Ser Tyr Ile Glu Glu Val Ala Lys Ala Tyr Glu 
    50                  55                  60                  

Lys Glu Ala Gly Val Lys Val Thr Leu Lys Thr Gly Asp Ala Leu Gly 
65                  70                  75                  80  

Gly Leu Asp Lys Leu Ser Leu Asp Asn Gln Ser Gly Asn Val Pro Asp 
                85                  90                  95      

Val Met Met Ala Pro Tyr Asp Arg Val Gly Ser Leu Gly Ser Asp Gly 
            100                 105                 110         

Gln Leu Ser Glu Val Lys Leu Ser Asp Gly Ala Lys Thr Asp Asp Thr 
        115                 120                 125             

Thr Lys Ser Leu Val Thr Ala Ala Asn Gly Lys Val Tyr Gly Ala Pro 
    130                 135                 140                 

Ala Val Ile Glu Ser Leu Val Met Tyr Tyr Asn Lys Asp Leu Val Lys 
145                 150                 155                 160 

Asp Ala Pro Lys Thr Phe Ala Asp Leu Glu Asn Leu Ala Lys Asp Ser 
                165                 170                 175     

Lys Tyr Ala Phe Ala Gly Glu Asp Gly Lys Thr Thr Ala Phe Leu Ala 
            180                 185                 190         

Asp Trp Thr Asn Phe Tyr Tyr Thr Tyr Gly Leu Leu Ala Gly Asn Gly 
        195                 200                 205             

Ala Tyr Val Phe Gly Gln Asn Gly Lys Asp Ala Lys Asp Ile Gly Leu 
    210                 215                 220                 

Ala Asn Asp Gly Ser Ile Val Gly Ile Asn Tyr Ala Lys Ser Trp Tyr 
225                 230                 235                 240 

Glu Lys Trp Pro Lys Gly Met Gln Asp Thr Glu Gly Ala Gly Asn Leu 
                245                 250                 255     

Ile Gln Thr Gln Phe Gln Glu Gly Lys Thr Ala Ala Ile Ile Asp Gly 
            260                 265                 270         

Pro Trp Lys Ala Gln Ala Phe Lys Asp Ala Lys Val Asn Tyr Gly Val 
        275                 280                 285             

Ala Thr Ile Pro Thr Leu Pro Asn Gly Lys Glu Tyr Ala Ala Phe Gly 
    290                 295                 300                 

Gly Gly Lys Ala Trp Val Ile Pro Gln Ala Val Lys Asn Leu Glu Ala 
305                 310                 315                 320 

Ser Gln Lys Phe Val Asp Phe Leu Val Ala Thr Glu Gln Gln Lys Val 
                325                 330                 335     

Leu Tyr Asp Lys Thr Asn Glu Ile Pro Ala Asn Thr Glu Ala Arg Ser 
            340                 345                 350         

Tyr Ala Glu Gly Lys Asn Asp Glu Leu Thr Thr Ala Val Ile Lys Gln 
        355                 360                 365             

Phe Lys Asn Thr Gln Pro Leu Pro Asn Ile Ser Gln Met Ser Ala Val 
    370                 375                 380                 

Trp Asp Pro Ala Lys Asn Met Leu Phe Asp Ala Val Ser Gly Gln Lys 
385                 390                 395                 400 

Asp Ala Lys Thr Ala Ala Asn Asp Ala Val Thr Leu Ile Lys Glu Thr 
                405                 410                 415     

Ile Lys Gln Lys Phe Gly Glu 
            420             

<210>   113
<211>   155
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   113
Met Ile Asp Lys Val Val Arg Asn Leu Leu Leu Thr Phe Phe Phe Cys 
1               5                   10                  15      

Lys Met Thr Lys Ile Ile Ile Phe Leu Thr Thr Ile Leu Val Lys Lys 
            20                  25                  30          

Lys Lys Ile Cys Tyr Asn Glu Phe Lys Leu Arg Asn Arg Lys Gln Lys 
        35                  40                  45              

Gly Val Ile Met Trp Val Leu Gly Phe Ile Leu Phe Met Ile Phe Phe 
    50                  55                  60                  

Tyr Ser Asn Asn Ser Lys Lys Ile Lys Lys Leu Glu Asn Lys Ile Lys 
65                  70                  75                  80  

Arg Leu Glu Arg Lys Glu Lys Gly Asn Ala Glu Met Ser Arg Leu Leu 
                85                  90                  95      

Gln Glu Met Ile Gly Lys Glu Pro Ile Ile Thr Gly Val Tyr Ile Gly 
            100                 105                 110         

Pro Asp Asn Trp Glu Val Val Asp Val Asp Glu Glu Trp Val Lys Leu 
        115                 120                 125             

Arg Arg Val Asp Asn Thr Gly Lys Glu Lys Phe Lys Leu Gln Arg Ile 
    130                 135                 140                 

Glu Asp Ile Gln Thr Val Glu Phe Asp Gly Glu 
145                 150                 155 

<210>   114
<211>   285
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   114
Met Ile Leu Ser Lys Asn Arg Glu Asp Gly Leu Arg Lys Phe Ala Thr 
1               5                   10                  15      

Asn Ile Arg Leu Asn Thr Leu Arg Thr Leu Asn His Leu Gly Phe Gly 
            20                  25                  30          

His Tyr Gly Gly Ser Leu Ser Ile Val Glu Val Leu Ala Val Leu Tyr 
        35                  40                  45              

Gly Glu Ile Met Pro Met Thr Pro Glu Ile Phe Ala Ala Arg Asp Arg 
    50                  55                  60                  

Asp Tyr Phe Ile Leu Ser Lys Gly His Gly Gly Pro Ala Leu Tyr Ser 
65                  70                  75                  80  

Thr Leu Tyr Leu Asn Gly Phe Phe Asp Lys Glu Phe Leu Tyr Ser Leu 
                85                  90                  95      

Asn Thr Asn Gly Thr Lys Leu Pro Ser His Pro Asp Arg Asn Leu Thr 
            100                 105                 110         

Pro Gly Ile Asp Met Thr Thr Gly Ser Leu Gly Gln Gly Ile Ser Val 
        115                 120                 125             

Ala Thr Gly Leu Ala Tyr Gly Gln Arg Ile Arg Lys Ser Pro Phe Tyr 
    130                 135                 140                 

Thr Tyr Ala Ile Val Gly Asp Gly Glu Leu Asn Glu Gly Gln Cys Trp 
145                 150                 155                 160 

Glu Ala Ile Gln Phe Ala Ser His Gln Gln Leu Ser Asn Leu Ile Val 
                165                 170                 175     

Phe Val Asp Asp Asn Lys Lys Gln Leu Asp Gly Phe Thr Lys Asp Ile 
            180                 185                 190         

Cys Asn Pro Gly Asp Phe Val Glu Lys Phe Ser Ala Phe Gly Phe Glu 
        195                 200                 205             

Ser Ile Arg Val Lys Gly Ser Asp Ile Arg Glu Ile Tyr Glu Gly Ile 
    210                 215                 220                 

Val Gln Leu Lys Gln Ser Asn Asn Ser Ser Pro Lys Cys Ile Val Leu 
225                 230                 235                 240 

Asp Thr Ile Lys Gly Gln Gly Val Gln Glu Leu Glu Glu Met Lys Ser 
                245                 250                 255     

Asn His His Leu Arg Pro Thr Val Glu Glu Lys Gln Met Leu Thr Ser 
            260                 265                 270         

Val Val Glu Arg Leu Ser Gln Glu Leu Glu Glu Thr Glu 
        275                 280                 285 

<210>   115
<211>   621
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   115
Met Lys Lys Thr Thr Ile Leu Ser Leu Thr Thr Ala Ala Val Ile Leu 
1               5                   10                  15      

Ala Ala Tyr Val Pro Asn Glu Pro Ile Leu Ala Asp Thr Pro Ser Ser 
            20                  25                  30          

Glu Val Ile Lys Glu Thr Lys Val Gly Ser Ile Ile Gln Gln Asn Asn 
        35                  40                  45              

Ile Lys Tyr Lys Val Leu Thr Val Glu Gly Asn Ile Gly Thr Val Gln 
    50                  55                  60                  

Val Gly Asn Gly Val Thr Pro Val Glu Phe Glu Ala Gly Gln Asp Gly 
65                  70                  75                  80  

Lys Pro Phe Thr Ile Pro Thr Lys Ile Thr Val Gly Asp Lys Val Phe 
                85                  90                  95      

Thr Val Thr Glu Val Ala Ser Gln Ala Phe Ser Tyr Tyr Pro Asp Glu 
            100                 105                 110         

Thr Gly Arg Ile Val Tyr Tyr Pro Ser Ser Ile Thr Ile Pro Ser Ser 
        115                 120                 125             

Ile Lys Lys Ile Gln Lys Lys Gly Phe His Gly Ser Lys Ala Lys Thr 
    130                 135                 140                 

Ile Ile Phe Asp Lys Gly Ser Gln Leu Glu Lys Ile Glu Asp Arg Ala 
145                 150                 155                 160 

Phe Asp Phe Ser Glu Leu Glu Glu Ile Glu Leu Pro Ala Ser Leu Glu 
                165                 170                 175     

Tyr Ile Gly Thr Ser Ala Phe Ser Phe Ser Gln Lys Leu Lys Lys Leu 
            180                 185                 190         

Thr Phe Ser Ser Ser Ser Lys Leu Glu Leu Ile Ser His Glu Ala Phe 
        195                 200                 205             

Ala Asn Leu Ser Asn Leu Glu Lys Leu Thr Leu Pro Lys Ser Val Lys 
    210                 215                 220                 

Thr Leu Gly Ser Asn Leu Phe Arg Leu Thr Thr Ser Leu Lys His Val 
225                 230                 235                 240 

Asp Val Glu Glu Gly Asn Glu Ser Phe Ala Ser Val Asp Gly Val Leu 
                245                 250                 255     

Phe Ser Lys Asp Lys Thr Gln Leu Ile Tyr Tyr Pro Ser Gln Lys Asn 
            260                 265                 270         

Asp Glu Ser Tyr Lys Thr Pro Lys Glu Thr Lys Glu Leu Ala Ser Tyr 
        275                 280                 285             

Ser Phe Asn Lys Asn Ser Tyr Leu Lys Lys Leu Glu Leu Asn Glu Gly 
    290                 295                 300                 

Leu Glu Lys Ile Gly Thr Phe Ala Phe Ala Asp Ala Ile Lys Leu Glu 
305                 310                 315                 320 

Glu Ile Ser Leu Pro Asn Ser Leu Glu Thr Ile Glu Arg Leu Ala Phe 
                325                 330                 335     

Tyr Gly Asn Leu Glu Leu Lys Glu Leu Ile Leu Pro Asp Asn Val Lys 
            340                 345                 350         

Asn Phe Gly Lys His Val Met Asn Gly Leu Pro Lys Leu Lys Ser Leu 
        355                 360                 365             

Thr Ile Gly Asn Asn Ile Asn Ser Leu Pro Ser Phe Phe Leu Ser Gly 
    370                 375                 380                 

Val Leu Asp Ser Leu Lys Glu Ile His Ile Lys Asn Lys Ser Thr Glu 
385                 390                 395                 400 

Phe Ser Val Lys Lys Asp Thr Phe Ala Ile Pro Glu Thr Val Lys Phe 
                405                 410                 415     

Tyr Val Thr Ser Glu His Ile Lys Asp Val Leu Lys Ser Asn Leu Ser 
            420                 425                 430         

Thr Ser Asn Asp Ile Ile Val Glu Lys Val Asp Asn Ile Lys Gln Glu 
        435                 440                 445             

Thr Asp Val Ala Lys Pro Lys Lys Asn Ser Asn Gln Gly Val Val Gly 
    450                 455                 460                 

Trp Val Lys Asp Lys Gly Leu Trp Tyr Tyr Leu Asn Glu Ser Gly Ser 
465                 470                 475                 480 

Met Ala Thr Gly Trp Val Lys Asp Lys Gly Leu Trp Tyr Tyr Leu Asn 
                485                 490                 495     

Glu Ser Gly Ser Met Ala Thr Gly Trp Val Lys Asp Lys Gly Leu Trp 
            500                 505                 510         

Tyr Tyr Leu Asn Glu Ser Gly Ser Met Ala Thr Gly Trp Val Lys Asp 
        515                 520                 525             

Lys Gly Leu Trp Tyr Tyr Leu Asn Glu Ser Gly Ser Met Ala Thr Gly 
    530                 535                 540                 

Trp Val Lys Asp Lys Gly Leu Trp Tyr Tyr Leu Asn Glu Ser Gly Ser 
545                 550                 555                 560 

Met Ala Thr Gly Trp Val Lys Asp Lys Gly Leu Trp Tyr Tyr Leu Asn 
                565                 570                 575     

Glu Ser Gly Ser Met Ala Thr Gly Trp Val Thr Val Ser Gly Lys Trp 
            580                 585                 590         

Tyr Tyr Thr Tyr Asn Ser Gly Asp Leu Leu Val Asn Thr Thr Thr Pro 
        595                 600                 605             

Asp Gly Tyr Arg Val Asn Ala Asn Gly Glu Trp Val Gly 
    610                 615                 620     

<210>   116
<211>   626
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   116
Met Val Arg Phe Thr Gly Leu Ser Leu Lys Gln Thr Gln Ala Ile Glu 
1               5                   10                  15      

Val Leu Lys Gly His Ile Ser Leu Pro Asp Val Glu Val Ala Val Thr 
            20                  25                  30          

Gln Ser Asp Gln Ala Ser Ile Ser Ile Glu Gly Glu Glu Gly His Tyr 
        35                  40                  45              

Gln Leu Thr Tyr Arg Lys Pro His Gln Leu Tyr Arg Ala Leu Ser Leu 
    50                  55                  60                  

Leu Val Thr Val Leu Ala Glu Ala Asp Lys Val Glu Ile Glu Glu Gln 
65                  70                  75                  80  

Ala Ala Tyr Glu Asp Leu Ala Tyr Met Val Asp Cys Ser Arg Asn Ala 
                85                  90                  95      

Val Leu Asn Val Ala Ser Ala Lys Gln Met Ile Glu Ile Leu Ala Leu 
            100                 105                 110         

Met Gly Tyr Ser Thr Phe Glu Leu Tyr Met Glu Asp Thr Tyr Gln Ile 
        115                 120                 125             

Glu Gly Gln Pro Tyr Phe Gly Tyr Phe Arg Gly Ala Tyr Ser Ala Glu 
    130                 135                 140                 

Glu Leu Gln Glu Ile Glu Ala Tyr Ala Gln Gln Phe Asp Val Thr Phe 
145                 150                 155                 160 

Val Pro Cys Ile Gln Thr Leu Ala His Leu Ser Ala Phe Val Lys Trp 
                165                 170                 175     

Gly Val Lys Glu Val Gln Glu Leu Arg Asp Val Glu Asp Ile Leu Leu 
            180                 185                 190         

Ile Gly Glu Glu Lys Val Tyr Asp Leu Ile Asp Gly Met Phe Ala Thr 
        195                 200                 205             

Leu Ser Lys Leu Lys Thr Arg Lys Val Asn Ile Gly Met Asp Glu Ala 
    210                 215                 220                 

His Leu Val Gly Leu Gly Arg Tyr Leu Ile Leu Asn Gly Val Val Asp 
225                 230                 235                 240 

Arg Ser Leu Leu Met Cys Gln His Leu Glu Arg Val Leu Asp Ile Ala 
                245                 250                 255     

Asp Lys Tyr Gly Phe His Cys Gln Met Trp Ser Asp Met Phe Phe Lys 
            260                 265                 270         

Leu Met Ser Ala Asp Gly Gln Tyr Asp Arg Asp Val Glu Ile Pro Glu 
        275                 280                 285             

Glu Thr Arg Val Tyr Leu Asp Arg Leu Lys Asp Arg Val Thr Leu Val 
    290                 295                 300                 

Tyr Trp Asp Tyr Tyr Gln Asp Ser Glu Glu Lys Tyr Asn Arg Asn Phe 
305                 310                 315                 320 

Arg Asn His His Lys Ile Ser His Asp Leu Ala Phe Ala Gly Gly Ala 
                325                 330                 335     

Trp Lys Trp Ile Gly Phe Thr Pro His Asn His Phe Ser Arg Leu Val 
            340                 345                 350         

Ala Ile Glu Ala Asn Lys Ala Cys Arg Ala Asn Gln Ile Lys Glu Val 
        355                 360                 365             

Ile Val Thr Gly Trp Gly Asp Asn Gly Gly Glu Thr Ala Gln Phe Ser 
    370                 375                 380                 

Ile Leu Pro Ser Leu Gln Ile Trp Ala Glu Leu Ser Tyr Arg Asn Asp 
385                 390                 395                 400 

Leu Asp Gly Leu Ser Ala His Phe Lys Thr Asn Thr Gly Leu Thr Val 
                405                 410                 415     

Glu Asp Phe Met Gln Ile Asp Leu Ala Asn Leu Leu Pro Asp Leu Pro 
            420                 425                 430         

Gly Asn Leu Ser Gly Ile Asn Pro Asn Arg Tyr Val Phe Tyr Gln Asp 
        435                 440                 445             

Ile Leu Cys Pro Ile Leu Asp Gln His Met Thr Pro Glu Gln Asp Lys 
    450                 455                 460                 

Pro His Phe Ala Gln Ala Ala Glu Thr Leu Ala Asn Ile Lys Glu Lys 
465                 470                 475                 480 

Ala Gly Asn Tyr Ala Tyr Leu Phe Glu Thr Gln Ala Gln Leu Asn Ala 
                485                 490                 495     

Ile Leu Ser Ser Lys Val Asp Val Gly Arg Arg Ile Arg Gln Ala Tyr 
            500                 505                 510         

Gln Ala Asp Asp Lys Glu Ser Leu Gln Gln Ile Ala Arg Gln Glu Leu 
        515                 520                 525             

Pro Glu Leu Arg Ser Gln Ile Glu Asp Phe His Ala Leu Phe Ser His 
    530                 535                 540                 

Gln Trp Leu Lys Glu Asn Lys Val Phe Gly Leu Asp Thr Val Asp Ile 
545                 550                 555                 560 

Arg Met Gly Gly Leu Leu Gln Arg Ile Lys Arg Ala Glu Ser Arg Ile 
                565                 570                 575     

Glu Val Tyr Leu Ala Gly Gln Leu Asp Arg Ile Asp Glu Leu Glu Val 
            580                 585                 590         

Glu Ile Leu Pro Phe Thr Asp Phe Tyr Ala Asp Lys Asp Phe Ala Ala 
        595                 600                 605             

Thr Thr Ala Asn Gln Trp His Thr Ile Ala Thr Ala Ser Thr Ile Tyr 
    610                 615                 620                 

Thr Thr 
625     

<210>   117
<211>   782
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   117
Met Ser Asn Ser Phe Val Lys Leu Leu Val Ser Gln Leu Phe Ala Asn 
1               5                   10                  15      

Leu Ala Asp Ile Phe Phe Arg Val Thr Ile Ile Ala Asn Ile Tyr Ile 
            20                  25                  30          

Ile Ser Lys Ser Val Ile Ala Thr Ser Leu Val Pro Ile Leu Ile Gly 
        35                  40                  45              

Ile Ser Ser Phe Val Ala Ser Leu Leu Val Pro Leu Val Thr Lys Arg 
    50                  55                  60                  

Leu Ala Leu Asn Arg Val Leu Ser Leu Ser Gln Phe Gly Lys Thr Ile 
65                  70                  75                  80  

Leu Leu Ala Ile Leu Val Gly Met Phe Thr Val Met Gln Ser Val Ala 
                85                  90                  95      

Pro Leu Val Thr Tyr Leu Phe Val Val Ala Ile Ser Ile Leu Asp Gly 
            100                 105                 110         

Phe Ala Ala Pro Val Ser Tyr Ala Ile Val Pro Arg Tyr Ala Thr Asp 
        115                 120                 125             

Leu Gly Lys Ala Asn Ser Ala Leu Ser Met Thr Gly Glu Ala Val Gln 
    130                 135                 140                 

Leu Ile Gly Trp Gly Leu Gly Gly Leu Leu Phe Ala Thr Ile Gly Leu 
145                 150                 155                 160 

Leu Pro Thr Thr Cys Ile Asn Leu Val Leu Tyr Ile Ile Ser Ser Phe 
                165                 170                 175     

Leu Met Leu Phe Leu Pro Asn Ala Glu Val Glu Val Leu Glu Ser Glu 
            180                 185                 190         

Thr Asn Leu Glu Ile Leu Leu Lys Gly Trp Lys Leu Val Ala Arg Asn 
        195                 200                 205             

Pro Arg Leu Arg Leu Phe Val Ser Ala Asn Leu Leu Glu Ile Phe Ser 
    210                 215                 220                 

Asn Thr Ile Trp Val Ser Ser Ile Ile Leu Val Phe Val Thr Glu Leu 
225                 230                 235                 240 

Leu Asn Lys Thr Glu Ser Tyr Trp Gly Tyr Ser Asn Thr Ala Tyr Ser 
                245                 250                 255     

Ile Gly Ile Ile Ile Ser Gly Leu Ile Ala Phe Arg Leu Ser Glu Lys 
            260                 265                 270         

Phe Leu Ala Ala Lys Trp Glu Pro Gln Leu Phe Thr Pro Asn Leu Lys 
        275                 280                 285             

Thr Ile Gln Asn Pro Cys Leu Ser Leu Asp Pro Gly Trp Phe Leu Phe 
    290                 295                 300                 

Ser Pro Asn Gly Cys Phe Leu Leu Asp Lys Lys Glu Phe Pro Leu Tyr 
305                 310                 315                 320 

Gly Ile Ser Val Glu Lys Asn Thr Lys Arg Lys Glu Thr His Met Asn 
                325                 330                 335     

Ser Leu Pro Asn His His Phe Gln Asn Lys Ser Phe Tyr Gln Leu Ser 
            340                 345                 350         

Phe Asp Gly Gly His Leu Thr Gln Tyr Gly Gly Leu Ile Phe Phe Gln 
        355                 360                 365             

Glu Leu Phe Ser Gln Leu Lys Leu Lys Glu Arg Ile Ser Lys Tyr Leu 
    370                 375                 380                 

Val Thr Asn Asp Gln Arg Arg Tyr Cys Arg Tyr Ser Asp Ser Asp Ile 
385                 390                 395                 400 

Leu Val Gln Phe Leu Phe Gln Leu Leu Thr Gly Tyr Gly Thr Asp Tyr 
                405                 410                 415     

Ala Cys Lys Glu Leu Ser Ala Asp Ala Tyr Phe Pro Lys Leu Leu Glu 
            420                 425                 430         

Gly Gly Gln Leu Ala Ser Gln Pro Thr Leu Ser Arg Phe Leu Ser Arg 
        435                 440                 445             

Thr Asp Glu Glu Thr Val His Ser Leu Arg Cys Leu Asn Leu Glu Leu 
    450                 455                 460                 

Val Glu Phe Phe Leu Gln Phe His Gln Leu Asn Gln Leu Ile Val Asp 
465                 470                 475                 480 

Ile Asp Ser Thr His Phe Thr Thr Tyr Gly Lys Gln Glu Gly Val Ala 
                485                 490                 495     

Tyr Asn Ala His Tyr Arg Ala His Gly Tyr His Pro Leu Tyr Ala Phe 
            500                 505                 510         

Glu Gly Lys Thr Gly Tyr Cys Phe Asn Ala Gln Leu Arg Pro Gly Asn 
        515                 520                 525             

Arg Tyr Cys Ser Glu Glu Ala Asp Ser Phe Ile Thr Pro Val Leu Glu 
    530                 535                 540                 

Arg Phe Asn Gln Leu Leu Phe Arg Met Asp Ser Gly Phe Ala Thr Pro 
545                 550                 555                 560 

Lys Leu Tyr Asp Leu Ile Glu Lys Thr Gly Gln Tyr Tyr Leu Ile Lys 
                565                 570                 575     

Leu Lys Lys Asn Thr Val Leu Ser Arg Leu Gly Asp Leu Ser Leu Pro 
            580                 585                 590         

Cys Pro Gln Asp Glu Asp Leu Thr Ile Leu Pro His Ser Ala Tyr Ser 
        595                 600                 605             

Glu Thr Leu Tyr Gln Ala Gly Ser Trp Ser His Lys Arg Arg Val Cys 
    610                 615                 620                 

Gln Phe Ser Glu Arg Lys Glu Gly Asn Leu Phe Tyr Asp Val Ile Ser 
625                 630                 635                 640 

Leu Val Thr Asn Met Thr Ser Gly Thr Ser Gln Asp Gln Phe Gln Leu 
                645                 650                 655     

Tyr Arg Gly Arg Gly Gln Ala Glu Asn Phe Ile Lys Glu Met Lys Glu 
            660                 665                 670         

Gly Phe Phe Gly Asp Lys Thr Asp Ser Ser Thr Leu Ile Lys Asn Glu 
        675                 680                 685             

Val Arg Met Met Met Ser Cys Ile Ala Tyr Asn Leu Tyr Leu Phe Leu 
    690                 695                 700                 

Lys His Leu Ala Gly Gly Asp Phe Gln Thr Leu Thr Ile Lys Arg Phe 
705                 710                 715                 720 

Arg His Leu Phe Leu His Val Val Gly Lys Cys Val Arg Thr Gly Arg 
                725                 730                 735     

Lys Gln Leu Leu Lys Leu Ser Ser Leu Tyr Ala Tyr Ser Glu Leu Phe 
            740                 745                 750         

Ser Ala Leu Tyr Ser Arg Ile Arg Lys Val Asn Leu Asn Leu Pro Val 
        755                 760                 765             

Pro Tyr Glu Pro Pro Arg Arg Lys Ala Ser Leu Met Met His 
    770                 775                 780         

<210>   118
<211>   810
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   118
Met Asn Tyr Ser Lys Ala Leu Asn Glu Cys Ile Glu Ser Ala Tyr Met 
1               5                   10                  15      

Val Ala Gly His Phe Gly Ala Arg Tyr Leu Glu Ser Trp His Leu Leu 
            20                  25                  30          

Ile Ala Met Ser Asn His Ser Tyr Ser Val Ala Gly Ala Thr Leu Asn 
        35                  40                  45              

Asp Tyr Pro Tyr Glu Met Asp Arg Leu Glu Glu Val Ala Leu Glu Leu 
    50                  55                  60                  

Thr Glu Thr Asp Tyr Ser Gln Asp Glu Thr Phe Thr Glu Leu Pro Phe 
65                  70                  75                  80  

Ser Arg Arg Leu Gln Val Leu Phe Asp Glu Ala Glu Tyr Val Ala Ser 
                85                  90                  95      

Val Val His Ala Lys Val Leu Gly Thr Glu His Val Leu Tyr Ala Ile 
            100                 105                 110         

Leu His Asp Ser Asn Ala Leu Ala Thr Arg Ile Leu Glu Arg Ala Gly 
        115                 120                 125             

Phe Ser Tyr Glu Asp Lys Lys Asp Gln Val Lys Ile Ala Ala Leu Arg 
    130                 135                 140                 

Arg Asn Leu Glu Glu Arg Ala Gly Trp Thr Arg Glu Asp Leu Lys Ala 
145                 150                 155                 160 

Leu Arg Gln Arg His Arg Thr Val Ala Asp Lys Gln Asn Ser Met Ala 
                165                 170                 175     

Asn Met Met Gly Met Pro Gln Thr Pro Ser Gly Gly Leu Glu Asp Tyr 
            180                 185                 190         

Thr His Asp Leu Thr Glu Gln Ala Arg Ser Gly Lys Leu Glu Pro Val 
        195                 200                 205             

Ile Gly Arg Asp Lys Glu Ile Ser Arg Met Ile Gln Ile Leu Ser Arg 
    210                 215                 220                 

Lys Thr Lys Asn Asn Pro Val Leu Val Gly Asp Ala Gly Val Gly Lys 
225                 230                 235                 240 

Thr Ala Leu Ala Leu Gly Leu Ala Gln Arg Ile Ala Ser Gly Asp Val 
                245                 250                 255     

Pro Ala Glu Met Ala Lys Met Arg Val Leu Glu Leu Asp Leu Met Asn 
            260                 265                 270         

Val Val Ala Gly Thr Arg Phe Arg Gly Asp Phe Glu Glu Arg Met Asn 
        275                 280                 285             

Asn Ile Ile Lys Asp Ile Glu Glu Asp Gly Gln Val Ile Leu Phe Ile 
    290                 295                 300                 

Asp Glu Leu His Thr Ile Met Gly Ser Gly Ser Gly Ile Asp Ser Thr 
305                 310                 315                 320 

Leu Asp Ala Ala Asn Ile Leu Lys Pro Ala Leu Ala Arg Gly Thr Leu 
                325                 330                 335     

Arg Thr Val Gly Ala Thr Thr Gln Glu Glu Tyr Gln Lys His Ile Glu 
            340                 345                 350         

Lys Asp Ala Ala Leu Ser Arg Arg Phe Ala Lys Val Thr Ile Glu Glu 
        355                 360                 365             

Pro Ser Val Ala Asp Ser Met Thr Ile Leu Gln Gly Leu Lys Ala Thr 
    370                 375                 380                 

Tyr Glu Lys His His Arg Val Gln Ile Thr Asp Glu Ala Val Glu Thr 
385                 390                 395                 400 

Ala Val Lys Met Ala His Arg Tyr Leu Thr Ser Arg His Leu Pro Asp 
                405                 410                 415     

Ser Ala Ile Asp Leu Leu Asp Glu Ala Ala Ala Thr Val Gln Asn Lys 
            420                 425                 430         

Ala Lys His Val Lys Ala Asp Asp Ser Asp Leu Ser Pro Ala Asp Lys 
        435                 440                 445             

Ala Leu Met Asp Gly Lys Trp Lys Gln Ala Ala Gln Leu Ile Ala Lys 
    450                 455                 460                 

Glu Glu Glu Val Pro Val Tyr Lys Asp Leu Val Thr Glu Ser Asp Ile 
465                 470                 475                 480 

Leu Thr Thr Leu Ser Arg Leu Ser Gly Ile Pro Val Gln Lys Leu Thr 
                485                 490                 495     

Gln Thr Asp Ala Lys Lys Tyr Leu Asn Leu Glu Ala Glu Leu His Lys 
            500                 505                 510         

Arg Val Ile Gly Gln Asp Gln Ala Val Ser Ser Ile Ser Arg Ala Ile 
        515                 520                 525             

Arg Arg Asn Gln Ser Gly Ile Arg Ser His Lys Arg Pro Ile Gly Ser 
    530                 535                 540                 

Phe Met Phe Leu Gly Pro Thr Gly Val Gly Lys Thr Glu Leu Ala Lys 
545                 550                 555                 560 

Ala Leu Ala Glu Val Leu Phe Asp Asp Glu Ser Ala Leu Ile Arg Phe 
                565                 570                 575     

Asp Met Ser Glu Tyr Met Glu Lys Phe Ala Ala Ser Arg Leu Asn Gly 
            580                 585                 590         

Ala Pro Pro Gly Tyr Val Gly Tyr Glu Glu Gly Gly Glu Leu Thr Glu 
        595                 600                 605             

Lys Val Arg Asn Lys Pro Tyr Ser Val Leu Leu Phe Asp Glu Val Glu 
    610                 615                 620                 

Lys Ala His Pro Asp Ile Phe Asn Val Leu Leu Gln Val Leu Asp Asp 
625                 630                 635                 640 

Gly Val Leu Thr Asp Ser Lys Gly Arg Lys Val Asp Phe Ser Asn Thr 
                645                 650                 655     

Ile Ile Ile Met Thr Ser Asn Leu Gly Ala Thr Ala Leu Arg Asp Asp 
            660                 665                 670         

Lys Thr Val Gly Phe Gly Ala Lys Asp Ile Arg Phe Asp Gln Glu Asn 
        675                 680                 685             

Met Glu Lys Arg Met Phe Glu Glu Leu Lys Lys Ala Tyr Arg Pro Glu 
    690                 695                 700                 

Phe Ile Asn Arg Ile Asp Glu Lys Val Val Phe His Ser Leu Ser Ser 
705                 710                 715                 720 

Asp His Met Gln Glu Val Val Lys Ile Met Val Lys Pro Leu Val Ala 
                725                 730                 735     

Ser Leu Thr Glu Lys Gly Ile Asp Leu Lys Leu Gln Ala Ser Ala Leu 
            740                 745                 750         

Lys Leu Leu Ala Asn Gln Gly Tyr Asp Pro Glu Met Gly Ala Arg Pro 
        755                 760                 765             

Leu Arg Arg Thr Leu Gln Thr Glu Val Glu Asp Lys Leu Ala Glu Leu 
    770                 775                 780                 

Leu Leu Lys Gly Asp Leu Val Ala Gly Ser Thr Leu Lys Ile Gly Val 
785                 790                 795                 800 

Lys Ala Gly Gln Leu Lys Phe Asp Ile Ala 
                805                 810 

<210>   119
<211>   448
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   119
Met Lys Ile Leu Pro Phe Ile Ala Arg Gly Thr Ser Tyr Tyr Leu Lys 
1               5                   10                  15      

Met Ser Val Lys Lys Leu Val Pro Phe Leu Val Val Gly Leu Met Leu 
            20                  25                  30          

Ala Ala Gly Asp Ser Val Tyr Ala Tyr Ser Arg Gly Asn Gly Ser Ile 
        35                  40                  45              

Ala Arg Gly Asp Asp Tyr Pro Ala Tyr Tyr Lys Asn Gly Ser Gln Glu 
    50                  55                  60                  

Ile Asp Gln Trp Arg Met Tyr Ser Arg Gln Cys Thr Ser Phe Val Ala 
65                  70                  75                  80  

Phe Arg Leu Ser Asn Val Asn Gly Phe Glu Ile Pro Ala Ala Tyr Gly 
                85                  90                  95      

Asn Ala Asn Glu Trp Gly His Arg Ala Arg Arg Glu Gly Tyr Arg Val 
            100                 105                 110         

Asp Asn Thr Pro Thr Ile Gly Ser Ile Thr Trp Ser Thr Ala Gly Thr 
        115                 120                 125             

Tyr Gly His Val Ala Trp Val Ser Asn Val Met Gly Asp Gln Ile Glu 
    130                 135                 140                 

Ile Glu Glu Tyr Asn Tyr Gly Tyr Thr Glu Ser Tyr Asn Lys Arg Val 
145                 150                 155                 160 

Ile Lys Ala Asn Thr Met Thr Gly Phe Ile His Phe Lys Asp Leu Asp 
                165                 170                 175     

Gly Gly Ser Val Gly Asn Ser Gln Ser Ser Thr Ser Thr Gly Gly Thr 
            180                 185                 190         

His Tyr Phe Lys Thr Lys Ser Ala Ile Lys Thr Glu Pro Leu Ala Ser 
        195                 200                 205             

Gly Thr Val Ile Asp Tyr Tyr Tyr Pro Gly Glu Lys Val His Tyr Asp 
    210                 215                 220                 

Gln Ile Leu Glu Lys Asp Gly Tyr Lys Trp Leu Ser Tyr Thr Ala Tyr 
225                 230                 235                 240 

Asn Gly Ser Tyr Arg Tyr Val Gln Leu Glu Ala Val Asn Lys Asn Pro 
                245                 250                 255     

Leu Gly Asn Ser Val Leu Ser Ser Thr Gly Gly Thr His Tyr Phe Lys 
            260                 265                 270         

Thr Lys Ser Ala Ile Lys Thr Glu Pro Leu Val Ser Ala Thr Val Ile 
        275                 280                 285             

Asp Tyr Tyr Tyr Pro Gly Glu Lys Val His Tyr Asp Gln Ile Leu Glu 
    290                 295                 300                 

Lys Asp Gly Tyr Lys Trp Leu Ser Tyr Thr Ala Tyr Asn Gly Ser Arg 
305                 310                 315                 320 

Arg Tyr Ile Gln Leu Glu Gly Val Thr Ser Ser Gln Asn Tyr Gln Asn 
                325                 330                 335     

Gln Ser Gly Asn Ile Ser Ser Tyr Gly Ser His Ser Ser Ser Thr Val 
            340                 345                 350         

Gly Trp Lys Lys Ile Asn Gly Ser Trp Tyr His Phe Lys Ser Asn Gly 
        355                 360                 365             

Ser Lys Ser Thr Gly Trp Leu Lys Asp Gly Ser Ser Trp Tyr Tyr Leu 
    370                 375                 380                 

Lys Leu Ser Gly Glu Met Gln Thr Gly Trp Leu Lys Glu Asn Gly Leu 
385                 390                 395                 400 

Trp Tyr Tyr Leu Gly Ser Ser Gly Ala Met Lys Thr Gly Trp Tyr Gln 
                405                 410                 415     

Val Ser Gly Lys Trp Tyr Tyr Ser Tyr Ser Ser Gly Ala Leu Ala Val 
            420                 425                 430         

Asn Thr Thr Val Asp Gly Tyr Arg Val Asn Ser Asp Gly Glu Arg Val 
        435                 440                 445             


<210>   120
<211>   150
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   120
Met Lys Val Ile Phe Leu Ala Asp Val Lys Gly Lys Gly Lys Lys Gly 
1               5                   10                  15      

Glu Ile Lys Glu Val Pro Thr Gly Tyr Ala Gln Asn Phe Leu Ile Lys 
            20                  25                  30          

Lys Asn Leu Ala Lys Glu Ala Thr Ala Gln Ala Val Gly Glu Leu Arg 
        35                  40                  45              

Gly Lys Gln Lys Ser Glu Glu Lys Ala His Ala Glu Met Ile Ala Glu 
    50                  55                  60                  

Gly Lys Ala Ile Lys Ala Gln Leu Glu Ala Glu Glu Thr Val Val Glu 
65                  70                  75                  80  

Phe Val Glu Lys Val Gly Pro Asp Gly Arg Thr Phe Gly Ser Ile Thr 
                85                  90                  95      

Asn Lys Lys Ile Ala Glu Glu Leu Gln Lys Gln Phe Gly Ile Lys Ile 
            100                 105                 110         

Asp Lys Arg His Ile Gln Val Gln Ala Pro Ile Arg Ala Val Gly Leu 
        115                 120                 125             

Ile Asp Val Pro Val Lys Ile Tyr Gln Asp Ile Thr Ser Val Ile Asn 
    130                 135                 140                 

Leu Arg Val Lys Glu Gly 
145                 150 

<210>   121
<211>   363
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   121
Met Ser Glu Ile Glu Ile Ile Asn Ala Lys Lys Ile Tyr His Asp Val 
1               5                   10                  15      

Pro Val Ile Glu Asn Leu Asn Ile Thr Ile Pro Lys Gly Ser Leu Phe 
            20                  25                  30          

Thr Leu Leu Gly Ala Ser Gly Cys Gly Lys Thr Thr Leu Leu Arg Met 
        35                  40                  45              

Ile Ala Gly Phe Asn Ser Ile Lys Asp Gly Glu Phe Tyr Phe Asp Asp 
    50                  55                  60                  

Thr Lys Ile Asn Asn Met Glu Pro Ser Lys Arg Asn Ile Gly Leu Val 
65                  70                  75                  80  

Phe Gln Asn Tyr Ala Ile Phe Pro His Leu Thr Val Arg Asp Asn Val 
                85                  90                  95      

Ala Phe Gly Leu Met Gln Lys Lys Val Pro Lys Glu Glu Leu Ile Gln 
            100                 105                 110         

Gln Thr Asn Lys Tyr Leu Glu Leu Met Gln Ile Ala Gln Tyr Ala Asp 
        115                 120                 125             

Arg Lys Pro Asp Lys Leu Ser Gly Gly Gln Gln Gln Arg Val Thr Leu 
    130                 135                 140                 

Ala Cys Ala Leu Ala Val Asn Pro Ser Val Leu Leu Met Asp Glu Pro 
145                 150                 155                 160 

Leu Ser Asn Leu Glu Ala Lys Leu Arg Leu Asp Met Arg Gln Thr Ile 
                165                 170                 175     

Arg Glu Ile Gln His Glu Val Gly Ile Thr Thr Val Tyr Val Thr His 
            180                 185                 190         

Asp Gln Glu Glu Ala Met Ala Ile Ser Asp Gln Ile Ala Val Met Lys 
        195                 200                 205             

Asp Gly Val Ile Gln Gln Ile Gly Arg Pro Lys Glu Leu Tyr His Lys 
    210                 215                 220                 

Pro Ala Asn Glu Phe Val Ala Thr Phe Ile Gly Arg Thr Asn Ile Ile 
225                 230                 235                 240 

Pro Ala Asn Leu Glu Lys Arg Ser Asp Gly Ala Tyr Ile Val Phe Ser 
                245                 250                 255     

Asp Gly Tyr Ala Leu Arg Met Pro Ala Leu Asp Gln Val Glu Glu Gln 
            260                 265                 270         

Ala Ile His Val Ser Ile Arg Pro Glu Glu Phe Ile Lys Asp Glu Ser 
        275                 280                 285             

Gly Asp Ile Glu Gly Thr Ile Arg Asp Ser Val Tyr Leu Gly Leu Asn 
    290                 295                 300                 

Thr Asp Tyr Phe Ile Glu Thr Gly Phe Ala Ser Lys Ile Gln Val Ser 
305                 310                 315                 320 

Glu Glu Ser Thr Phe Glu Glu Glu Leu Gln Lys Gly Asn Arg Ile Arg 
                325                 330                 335     

Leu Arg Ile Asn Thr Gln Lys Leu Asn Ile Phe Ser Ala Asp Gly Ser 
            340                 345                 350         

Gln Asn Leu Ile Lys Gly Val Asn His Gly Thr 
        355                 360             

<210>   122
<211>   129
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   122
Met Val Lys Arg Arg Ile Arg Arg Gly Thr Arg Glu Pro Glu Lys Val 
1               5                   10                  15      

Val Val Pro Glu Gln Ser Ser Ile Pro Ser Tyr Pro Val Ser Val Thr 
            20                  25                  30          

Ser Asn Gln Gly Thr Asp Val Ala Val Glu Pro Ala Lys Ala Val Ala 
        35                  40                  45              

Pro Thr Thr Asp Trp Lys Gln Glu Asn Gly Met Trp Tyr Phe Tyr Asn 
    50                  55                  60                  

Thr Asp Gly Ser Met Ala Thr Gly Trp Val Gln Val Asn Ser Ser Trp 
65                  70                  75                  80  

Tyr Tyr Leu Asn Ser Asn Gly Ser Met Lys Val Asn Gln Trp Phe Gln 
                85                  90                  95      

Val Gly Gly Lys Trp Tyr Tyr Val Asn Thr Ser Gly Glu Leu Ala Val 
            100                 105                 110         

Asn Thr Ser Ile Asp Gly Tyr Arg Val Asn Asp Asn Gly Glu Trp Val 
        115                 120                 125             

Arg 
    

<210>   123
<211>   46
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   123
Glu Leu Arg Arg Leu Ser Arg Leu Val Asp Gln Glu Leu Tyr Phe Gly 
1               5                   10                  15      

Cys Gly Trp Arg Leu Ser Leu Glu Trp Leu Pro Ser Met Arg Lys Asp 
            20                  25                  30          

Ser Trp Pro Ser Asn Thr Ala Pro Arg Thr Thr Met Val Gln 
        35                  40                  45      

<210>   124
<211>   31
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   124
Asp Cys Ile Arg Lys Gln Pro Phe Thr Arg Asp Glu Pro Asn Lys Thr 
1               5                   10                  15      

Cys Arg Lys Thr Lys Pro Ser Lys Ser Tyr Cys Ser Tyr Arg Trp 
            20                  25                  30      

<210>   125
<211>   26
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   125
Gly Gln Arg Asn Pro Arg Arg Ile Glu Arg Val Ile Arg Met Ala Glu 
1               5                   10                  15      

Thr Lys Pro Arg Ile Ser Lys Lys Glu Gly 
            20                  25      

<210>   126
<211>   83
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   126
Gln Arg Lys Leu Phe Lys Ile Phe His Leu Phe Gln Lys Lys Ser Gly 
1               5                   10                  15      

Trp Asn Gln Lys Ser Ser Cys Leu Lys Leu Asn Leu Asn Ser Leu Asn 
            20                  25                  30          

Arg Lys Met Thr Gln Met Thr Lys Met Phe Arg Ser Ile Phe Gln Pro 
        35                  40                  45              

Lys Lys Pro Leu Asn Thr Asn Phe Gln Ala Tyr Asn Ser Leu His Gln 
    50                  55                  60                  

Ile Asn Gln Lys Ile Ser Leu Lys Arg Arg Lys Leu Ser Glu Lys Ile 
65                  70                  75                  80  

Ser Lys Ser 
            

<210>   127
<211>   104
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   127
Leu Val Ile Ile Val Leu Lys Ile Gln Ser Lys Ser Glu Thr Asp Phe 
1               5                   10                  15      

Ile Phe Lys Thr Trp Pro Phe Ile Leu Leu Ser Lys Ile Ile Pro Leu 
            20                  25                  30          

Met Val Leu Asp Cys Gln Val Ser Ile Ser Trp Thr Asn Arg Glu Thr 
        35                  40                  45              

Val Ala Tyr Ser Lys Leu Leu Ala Ile Lys Thr Leu Lys Gly Asp Tyr 
    50                  55                  60                  

His Asp Gly Gln Ser Lys Lys Ile Arg Leu Ser His Ala Ser Arg Val 
65                  70                  75                  80  

Arg Thr Pro Ser Trp Tyr Pro His Asp Met Ala Asp Ser Thr Arg Ile 
                85                  90                  95      

Met Ala Phe Ser Arg Lys Gly Cys 
            100                 

<210>   128
<211>   30
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   128
Glu Arg Leu Pro Ala Phe Pro Arg Ser Leu Ser Gly Arg Lys Leu Asp 
1               5                   10                  15      

Gln Gly Gly Thr Lys Glu Lys Gly Ser Asp Gly Arg Ser Pro 
            20                  25                  30  

<210>   129
<211>   245
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   129
Arg Asn Cys Leu Ser Thr Trp Lys Ser Ser Ser Asn Tyr His Thr Glu 
1               5                   10                  15      

Ile Lys Arg Gly Thr Val Arg Gln Cys Leu Gly Lys Gly Arg Phe Lys 
            20                  25                  30          

Glu Val Tyr Ser Ala Asp Tyr Ala Gln Gln Ser Tyr Glu Asn Asn Arg 
        35                  40                  45              

Lys Arg Ser Val Lys Lys Ser Ser Leu Thr Lys Glu Leu Lys Glu Lys 
    50                  55                  60                  

Ile Leu His Tyr His Asn Gln Lys Phe Ser Pro Glu Met Met Val Met 
65                  70                  75                  80  

Ala Lys Gly Val Asn Val Gly Ile Ser Thr Ile Tyr Tyr Trp Ile His 
                85                  90                  95      

His Gly Lys Leu Gly Leu Ser Lys Gln Asp Leu Leu Tyr Pro Arg Lys 
            100                 105                 110         

Gly Lys Ala Leu Lys Lys Gln Ala Ser Thr Asn Phe Lys Pro Ala Gly 
        115                 120                 125             

Gln Ser Ile Glu Gln Arg Pro Glu Ala Ile Asn Leu Arg Leu Glu Asn 
    130                 135                 140                 

Gly His Tyr Glu Ile Asp Thr Val Leu Leu Thr Arg Ser Lys Asn Tyr 
145                 150                 155                 160 

Cys Leu Ile Val Leu Thr Asp Arg Lys Ser Arg His Gln Ile Ile Arg 
                165                 170                 175     

Leu Ile Pro Asn Lys Ser Ala Glu Val Val Asn Gln Ala Leu Lys Leu 
            180                 185                 190         

Ile Leu Lys Gln His Lys Ile Leu Ser Ile Thr Ala Asp Asn Gly Thr 
        195                 200                 205             

Glu Phe Asn Arg Leu Phe Asp Ile Phe Ser Glu Glu His Ile Tyr Tyr 
    210                 215                 220                 

Ala His Pro Tyr Ala Ser Trp Glu Arg Gly Thr Asn Glu Asn His Asn 
225                 230                 235                 240 

Arg Leu Ile Arg Arg 
                245 

<210>   130
<211>   36
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   130
Pro Val Met Thr Ile Ser Ser Pro Thr Met Lys Asn Met Asp Leu Ser 
1               5                   10                  15      

Thr Lys Ala Ser Pro Ser Gln Pro Leu Gln Gly Lys His Gly Met Ile 
            20                  25                  30          

Trp Ser Gly Lys 
        35      

<210>   131
<211>   28
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   131
Thr Ser Ser Ile Arg Ile His Thr Arg Lys Ser Ser Pro Asn Trp Thr 
1               5                   10                  15      

Thr Thr Pro His Leu Ala Leu Ser Ala Glu Thr Asn 
            20                  25              

<210>   132
<211>   27
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   132
Tyr Phe Leu Pro His Lys Tyr Ala Arg Glu Ser Leu Ser Leu Pro Ser 
1               5                   10                  15      

Thr Asn Lys Ile Leu His Arg Lys Gln Gly Ser 
            20                  25          

<210>   133
<211>   53
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   133
Ala Ala Phe Lys Lys Asp Gln Ile Asn Glu Arg Val Glu Lys Leu Gly 
1               5                   10                  15      

Lys Leu Lys Pro Ile Thr Ile Asn Tyr Asn Gly Lys Ser Glu Val Ile 
            20                  25                  30          

Asp Ser Lys Glu Lys Leu Gln Glu Leu Met Asn Lys Ala Val Lys Asp 
        35                  40                  45              

Glu Val Ala Gln Ile 
    50              

<210>   134
<211>   33
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   134
Ala Tyr Ala His Ser Lys Arg Ser Ala Gly Ser Gly Arg Ala Gly Gly 
1               5                   10                  15      

Arg Gln Cys Leu Cys Gln Cys Gln Asn Lys Cys Arg Arg Asp Phe Lys 
            20                  25                  30          

Tyr 
    

<210>   135
<211>   36
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   135
His Gly Arg Pro Tyr His Lys Pro His Gln Pro His His His Gly Phe 
1               5                   10                  15      

Pro Gln Gln Ser Tyr Asn Leu Leu Pro Pro Lys His Lys Pro Thr Leu 
            20                  25                  30          

Cys Val Arg Arg 
        35      

<210>   136
<211>   130
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   136
Lys Gly Lys Ile Leu Leu Leu Pro Arg Leu Thr Thr Gln Arg Trp Gln 
1               5                   10                  15      

Arg Lys Ile Arg Pro Asp Ser Arg Lys Ser Ala Asn Asn Lys Ala Asn 
            20                  25                  30          

Leu Asp Phe His Asn Ser Arg Cys Lys Ser Ser Leu Ser Asp Glu Ala 
        35                  40                  45              

Pro Asn Leu His Lys Asn Pro Ala Leu Leu Val His Ser Leu Ser Arg 
    50                  55                  60                  

Val Ile Ala Val Leu Leu Glu Leu Ser Pro Leu Gln Ala Tyr Ser Ile 
65                  70                  75                  80  

Val Lys Phe Ser Pro Lys Glu Asp Asp Leu Ile His Asp Asp Ala Ile 
                85                  90                  95      

Leu Val Arg Phe Gly Ile Leu Glu Val His Asp Ser Pro Tyr Glu Leu 
            100                 105                 110         

Leu Leu Leu Tyr His Thr His Ser Tyr Arg Phe Ser Cys Ser Ile Tyr 
        115                 120                 125             

Leu Ser 
    130 

<210>   137
<211>   144
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   137
Phe Thr Val Ser His Val Phe Leu Leu Tyr Leu Ser Phe Asn Pro Arg 
1               5                   10                  15      

Pro Lys Ser Met Ser Leu Ser Phe Thr Ser Ser Lys Leu Leu Arg Pro 
            20                  25                  30          

Arg Phe Arg Thr Phe Ile Ile Ser Ala Ser Asp Phe Ser Val Lys Ser 
        35                  40                  45              

Cys Thr Val Leu Ile Pro Ala Arg Phe Lys Gln Leu Tyr Glu Arg Thr 
    50                  55                  60                  

Asp Lys Ser Ser Ser Ser Ile Val Arg Ser Lys Ile Arg Ser Ser Asp 
65                  70                  75                  80  

Ser Val Ser Ala Ser Phe Ile Thr Ser Val Asp Leu Ala Ile Ser Val 
                85                  90                  95      

Arg Phe Val Asn Lys Ser Arg Cys Ser Val Lys Ile Arg Ala Glu Ser 
            100                 105                 110         

Pro Lys Ala Ser Ser Gly Ile Ile Val Pro Phe Val Lys Ile Ser Arg 
        115                 120                 125             

Val Asn Leu Ser Lys Pro Ser Leu Leu Pro Thr Arg Ala Gly Ser Thr 
    130                 135                 140                 


<210>   138
<211>   18
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   138
Leu Val Cys Met Lys Asn Lys Gly Cys Tyr Lys Glu Arg Asn Asn Cys 
1               5                   10                  15      

Cys His 
        

<210>   139
<211>   58
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   139
Phe His Tyr Leu Ser Lys Tyr Phe Leu Val Ser Ala Ile Thr Thr Gly 
1               5                   10                  15      

Asp Lys Thr Lys Arg Ala Ile Lys Phe Gly Arg Ala Ile Lys Ala Leu 
            20                  25                  30          

Thr Ile Ser Ala Ile Ile Gln Thr Ile Ser Asn Ser Ile Asn Pro Pro 
        35                  40                  45              

Asn Lys Thr Met Ser Thr Lys Thr Thr Arg 
    50                  55              

<210>   140
<211>   47
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   140
Gly Lys Lys Val Phe Ile Lys Tyr Pro Leu Ser Arg Val Ser Ser Lys 
1               5                   10                  15      

Thr Gly Pro Met Ile Thr Gly Arg Thr Lys Asp Lys Ile Val Asp Lys 
            20                  25                  30          

Lys Val Gly Cys Pro Phe Glu Lys Ser Thr Val Lys Tyr Ser Ser 
        35                  40                  45          

<210>   141
<211>   37
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   141
Ser Ser Pro Val Phe Pro Lys Leu Val Met Val Ser Gly Ala Asn Lys 
1               5                   10                  15      

Pro Arg Glu Arg Arg Asn Phe Pro Phe Ser Ser Lys Met Ser Phe His 
            20                  25                  30          

Leu Thr Phe Val Leu 
        35          

<210>   142
<211>   77
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   142
Tyr Leu Thr Ser Phe Ser Val Pro Lys Ile Ala Ser Ser Lys Val Lys 
1               5                   10                  15      

Leu Thr Arg Tyr Trp Arg Ser Ser Pro Trp Arg Gly Ala Phe Gly Leu 
            20                  25                  30          

Arg Glu Glu Pro Pro Pro Pro Lys Lys Leu Glu Lys Ile Ser Ser Lys 
        35                  40                  45              

Pro Pro Lys Pro Pro Ala Pro Leu Lys Pro Pro Lys Pro Pro Ala Pro 
    50                  55                  60                  

Pro Lys Pro Pro Leu Ala Pro Ala Ala Pro Tyr Trp Ser 
65                  70                  75          

<210>   143
<211>   89
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   143
Gln Ser Trp Arg Pro Ile Pro Asp Ser Lys Cys Tyr Thr Gln Glu Lys 
1               5                   10                  15      

Leu Thr Ile Pro Ile Lys Arg Arg Lys Asp Ile Lys Asp Phe Tyr His 
            20                  25                  30          

Asn Ser Ile Gln Arg His Lys Asn Ser His Lys Ser His Leu Leu Asp 
        35                  40                  45              

Ser Tyr Arg Leu Ile Ile Thr Arg Leu Ala Glu Ile Val His Glu Asn 
    50                  55                  60                  

Lys Ile Leu Ile Val Leu Ile Leu Tyr Val Thr Asn Ile Pro Ser Arg 
65                  70                  75                  80  

Ser Arg Arg Tyr Glu Val Asn Arg Val 
                85                  

<210>   144
<211>   60
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   144
Leu Phe Arg Phe Tyr Arg Val Ile Val Leu Tyr Arg Gly Trp His Ile 
1               5                   10                  15      

Tyr Leu Leu Ile Leu Val Asn Leu Gln Tyr Val Gln Asn Val Phe Arg 
            20                  25                  30          

Lys Asp Arg Phe Leu Val Arg Gly Ala Gln Pro Phe Phe His Gly Glu 
        35                  40                  45              

Arg Ser Ala Gly His Leu Val Leu Pro Tyr Val Leu 
    50                  55                  60  

<210>   145
<211>   60
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   145
Ile Thr His Pro Pro Leu Asn Pro Glu His Phe Val Ser Arg Val Phe 
1               5                   10                  15      

Ser Ser Leu Gly Leu Lys Ser Tyr Gln Pro Lys Asp Asp Arg Phe Leu 
            20                  25                  30          

Arg Lys Pro Ser Asp Ser Arg His Pro Glu Ser Gly Asn Ser Gly Lys 
        35                  40                  45              

Trp Gln Val Leu Asn Ser Pro Leu Val Ile Val Lys 
    50                  55                  60  

<210>   146
<211>   30
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   146
Thr Leu Ala Lys Ala Val Gly Leu Met Tyr Ser Pro Pro Ile Pro Pro 
1               5                   10                  15      

Lys Pro Phe Leu Gly Arg Ile Thr Thr Asp Ser Ser Ser Ile 
            20                  25                  30  

<210>   147
<211>   83
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   147
Pro Gly Ser Pro Phe Ser Glu Ile Ser Gly Ala Gly Phe Phe Gly Val 
1               5                   10                  15      

Ala Lys Arg Ile Phe Pro Arg Pro Pro Arg Pro Pro Trp Ala Thr Ile 
            20                  25                  30          

Asn Ser Cys Pro Cys Ser Ile Lys Ser Val Lys Thr Leu Pro Val Ser 
        35                  40                  45              

Ala Ser Arg Thr Val Val Pro Cys Gly Thr Arg Thr Leu Arg Ser Ser 
    50                  55                  60                  

Ala Pro Arg Pro Cys Ile Pro Leu Val Ile Pro Phe Ser Pro Glu Ser 
65                  70                  75                  80  

Ala Leu Lys 
            

<210>   148
<211>   111
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   148
Ile Asn Ser Leu Thr Leu Ala Thr Ser Leu Ser Lys Arg Arg Ala Pro 
1               5                   10                  15      

Arg Lys Ala Ser Lys Ala Ser Pro Arg Met Val Ser Arg Leu Arg Pro 
            20                  25                  30          

Pro Asp Phe Ser Ser Pro Leu Pro Asn Leu Ile Asn Trp Ser Asn Trp 
        35                  40                  45              

Gln Ser Arg Ala Lys Pro Ala Lys Leu Ser Ser Arg Thr Ile Ile Ala 
    50                  55                  60                  

Arg Ser Phe Asp Arg Ser Pro Ser Gly Phe Leu Gly Tyr Phe Leu Tyr 
65                  70                  75                  80  

Arg Tyr Ser Glu Ile Asn Asn Cys Arg Thr Ala Ser Pro Lys Asn Ser 
                85                  90                  95      

Lys Arg Ser Leu Cys Glu Ile Phe Lys Arg Arg Cys Ser Leu Ala 
            100                 105                 110     

<210>   149
<211>   49
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   149
Pro Ile Gly Lys Arg Asn Cys Lys Ala Glu Cys Gln Ser His His Leu 
1               5                   10                  15      

Leu Glu Lys Gln Lys Thr Phe Gln Ser Arg Lys Thr Lys Arg Tyr Gly 
            20                  25                  30          

Ala Ser Pro Glu Pro Arg Tyr Arg Glu Ser Arg Lys Pro Arg Leu Ser 
        35                  40                  45              

Gln 
    

<210>   150
<211>   58
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   150
Gln Pro Leu Gly His Ser Lys Ala Glu Glu His Glu Thr Ile Cys Ser 
1               5                   10                  15      

His Thr Phe Asp Asn His Thr Thr Glu Thr Ile Pro Asn Gln Val Lys 
            20                  25                  30          

Gly Arg Asp Met Thr Ser Ser Glu Thr Leu Pro Phe Pro Ser Lys Asn 
        35                  40                  45              

Gln Asn Gln Gly Lys Ala Lys Gln Ile Pro 
    50                  55              

<210>   151
<211>   125
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   151
Pro Cys Ser Leu Pro Asp Tyr Gly Leu Val Gly Ser Gly Tyr His Ser 
1               5                   10                  15      

Cys His Tyr Gln Ser Asn Asp Thr Arg Phe Leu Glu Ser His Gly Asn 
            20                  25                  30          

Trp Arg Thr Leu Leu Tyr Ser Trp Ser Trp Ile Leu Cys Gln Glu Lys 
        35                  40                  45              

Thr Leu Phe Pro His Asp Leu Ala Ser Leu Tyr Pro Ser Cys Val Arg 
    50                  55                  60                  

Thr Ser Ile His Arg Tyr Cys Leu Leu His Val Lys Lys Leu Arg Asn 
65                  70                  75                  80  

Ser Ile Ser Thr Phe Phe Phe Thr His Ile Asp Lys Val Leu Val Gln 
                85                  90                  95      

Ala His Ile Ile Ser Gln Phe Trp Met Lys Arg Thr Tyr Gln His Ile 
            100                 105                 110         

Phe Phe Leu Gly Cys Asn Asn Leu Ile Val His Cys Cys 
        115                 120                 125 

<210>   152
<211>   69
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   152
Arg Val Lys Asp Asn His Leu Asp Lys Leu Val Lys Ala Leu Leu Lys 
1               5                   10                  15      

Arg Arg Ser Ser Thr Gln Tyr Tyr Ile His Gln Leu Leu Arg Lys Met 
            20                  25                  30          

Ile Arg Leu Tyr Gly His Gln Gln Leu His Asn Asn Ser Glu Ile Leu 
        35                  40                  45              

Val Tyr Ser Asp Tyr Gly His Val Asp Leu Leu Leu Leu Glu Thr Asn 
    50                  55                  60                  

Lys Ile Pro Val Tyr 
65                  

<210>   153
<211>   40
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   153
Gln Val Ile Lys Ile Asp Ile Ala Thr Thr Asn Lys Thr Glu Ser Val 
1               5                   10                  15      

Lys Ser Gln Ser Glu Arg Glu Lys Lys Arg Leu Thr Ser Ser Asn Ile 
            20                  25                  30          

Leu Lys Val Arg Gly Arg Pro Ile 
        35                  40  

<210>   154
<211>   32
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   154
Ala Phe Lys Ser Ser Lys Val Pro Ser Leu Asp Pro Ser Ser Thr Lys 
1               5                   10                  15      

Thr Tyr Ser Ile Ser Val Ser Lys Ser Gly Ser Lys Ala Ser Arg Ala 
            20                  25                  30          


<210>   155
<211>   69
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   155
Asp Lys Thr Asp Pro Leu Ala Arg Lys Leu Pro Asp Lys Ser Lys Pro 
1               5                   10                  15      

Ser Thr Ser Phe Cys Thr Lys Ser Leu Ser Pro Val Asn Met Ala Ser 
            20                  25                  30          

Leu Thr Ser Ala Lys Pro Ser Lys Thr Lys Ala Ser Leu Gly Ile Cys 
        35                  40                  45              

Ser Pro Ala Asp Lys Arg Met Thr Ser Pro Ser Thr Asn Ser Ser Gly 
    50                  55                  60                  

Leu Arg Ala Thr Ser 
65                  

<210>   156
<211>   38
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   156
Leu Cys Arg Leu Gln Thr Gln Ala Arg Pro Arg Gly Ser Val Thr Asn 
1               5                   10                  15      

Leu Thr Lys Gln Asn Lys Val Tyr Arg Tyr Leu Asn Tyr Leu Arg Gln 
            20                  25                  30          

Thr Gln Leu Ser Ala Met 
        35              

<210>   157
<211>   110
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   157
Cys Ile Gln Ser Ile Gly Asn Glu Gly Gln Cys Lys Gly Asn Ser Cys 
1               5                   10                  15      

Tyr Val Gly Lys Glu Ile His Leu Ala Pro Ile Ser Asp Ile Val Gly 
            20                  25                  30          

His Lys Gly Lys Glu Glu Gly Asp Asp Gly Asn Asp Asp Gly Arg Gln 
        35                  40                  45              

Phe Tyr Leu Phe Leu Ala His Leu Val Gly Ser Ala Phe Leu Arg Ser 
    50                  55                  60                  

Phe Pro Leu Leu Tyr Ser Lys Gly Ile Asn Glu Glu Gly Asp Gly Ile 
65                  70                  75                  80  

Gly Asn Asp Gly Arg Leu Ile Ser Lys Asp Ile Ile Asn Ser Thr Gly 
                85                  90                  95      

Gln Asn Gly Ile Asn Asn Thr Lys Val Ile Ser Pro Phe Ala 
            100                 105                 110 

<210>   158
<211>   121
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   158
Thr Ser Thr Lys Leu Val Ile Asp Thr Thr Thr Phe Met Thr Phe Cys 
1               5                   10                  15      

Thr Asn Asn Thr Lys Ser Ser Lys Phe Thr Asn Thr Phe Thr Lys Leu 
            20                  25                  30          

Asp Val Gly Thr Thr Thr Arg His Val Gly Cys Asp Gly Asn Gly Thr 
        35                  40                  45              

Thr Leu Thr Ser Ile His Asp Asp Leu Gly Phe Ser Ile Val Val Phe 
    50                  55                  60                  

Gly Ile Gln Asp Phe Val Arg Asn Thr Ser Cys Asn Gln Phe Leu Arg 
65                  70                  75                  80  

Asn Val Val Thr Ser Phe Asn Arg Tyr Cys Thr Asn Gln Asp Arg Leu 
                85                  90                  95      

Thr Leu Leu Val Thr Ser Leu Asn Val Phe Asp Asn Arg Phe Lys Leu 
            100                 105                 110         

Arg Phe Asp Thr Cys Ile Lys Lys Val 
        115                 120     

<210>   159
<211>   27
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   159
Ile Ser Thr Gly Val Pro Thr Cys Ser Met Tyr Pro Leu Leu Lys Thr 
1               5                   10                  15      

Ala Ile Leu Ser Asp Lys Val Lys Ala Ser Ser 
            20                  25          

<210>   160
<211>   34
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   160
Leu Ser Thr Met Ser Ser Ile Lys Ser Ile Leu Cys Ser Leu Pro Thr 
1               5                   10                  15      

His Thr Ile Phe Ser Lys Ser Ala Ile Ser Pro Lys Arg Gly Ser Thr 
            20                  25                  30          

Ala Ile 
        

<210>   161
<211>   111
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   161
Ser Cys Ser Tyr Ser Ser Thr Asn Ser Lys Ala Cys Ser Ile Val Gly 
1               5                   10                  15      

Leu Ser Lys Pro Thr Ile Phe Ile Cys Val Thr Pro Ile Ser Ala Ala 
            20                  25                  30          

Lys Ala Ile Ser Ser Ala Ser Arg Pro Ala Asn Ser Ser Thr Phe Lys 
        35                  40                  45              

Cys Val Cys Val Ser Lys Ile Ile Ser Ser Asn Leu Val Phe Tyr Leu 
    50                  55                  60                  

Leu Leu Tyr Gln Lys Arg Gly Gly Ala Pro Asn Phe Ser Val Ser Pro 
65                  70                  75                  80  

Pro Leu Phe Asn Arg Glu Leu Phe Cys Tyr Leu Phe Tyr Pro Ile Leu 
                85                  90                  95      

Pro Ile Ser Tyr Ser Thr Val Arg Asp Arg Arg Asp Trp Leu His 
            100                 105                 110     

<210>   162
<211>   110
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   162
Val Thr Ser Cys Ile Val Pro Ala Val Ala Cys Gly Ala Leu Val Val 
1               5                   10                  15      

Leu Gly Ala Ala Leu Gly Ala Thr Gly Leu Leu Gly Thr Val Thr Met 
            20                  25                  30          

Ala Met Ala Cys Thr Pro Ile Val Ser Ala Ser Phe Thr Ser Ser Ile 
        35                  40                  45              

Val Phe Ala Phe Ser Ile Ser Leu Arg Ala Ala Cys Phe Ser Ala Ser 
    50                  55                  60                  

Thr Leu Ala Lys Ser Ser Ala Phe Ser Leu Ser Glu Ser Gly Ala Pro 
65                  70                  75                  80  

Leu Ile Ser Ser Cys Leu Ser Leu Ala Ala Phe Ser Met Ala Phe Leu 
                85                  90                  95      

Ala Asp Ser Phe Ser Val Ala Asn Cys Leu Glu Ala Cys Asp 
            100                 105                 110 

<210>   163
<211>   53
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   163
Tyr Ser Pro Phe Asn His Ser Ile Leu Ile Arg Lys Thr Thr Lys Ile 
1               5                   10                  15      

Ile Asn Pro Asn Pro Lys Ala Pro Arg Met Asn Trp Arg Ser Lys Val 
            20                  25                  30          

Trp Ser Asn Gln Pro Val Asn Ile Ser Thr Asn His Thr Lys Ser Asp 
        35                  40                  45              

Arg Pro Ile Lys Lys 
    50              

<210>   164
<211>   48
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   164
Asp Tyr Phe Lys Phe Arg Thr Thr Phe Thr Arg Phe Ser Thr Val Lys 
1               5                   10                  15      

Pro Tyr Ser Ala Asn Thr Phe Gly Ala Gly Ala Glu Ala Pro Lys Val 
            20                  25                  30          

Ser Ile Pro Arg Thr Ala Pro Ser Arg Pro Thr Tyr Leu Tyr Gln Phe 
        35                  40                  45              


<210>   165
<211>   74
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   165
Arg Gly Arg Arg Gly Leu Cys Val Ala Arg Ile Lys Ala Pro Arg Leu 
1               5                   10                  15      

Val Ile Lys Pro Lys Arg Thr Ile Asp Pro Pro Thr Lys Asp Arg Tyr 
            20                  25                  30          

Ser Pro Pro Leu Ser Ala Thr Ser Leu Ser Val Pro Lys Ser Pro Ile 
        35                  40                  45              

Ile Ser Phe Pro Ala Lys Met Asp Lys Asn Pro Lys Arg Lys Leu Asn 
    50                  55                  60                  

Ser Lys Val Ile Phe Asn Ala Ser Val Thr 
65                  70                  

<210>   166
<211>   30
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   166
Thr Pro Pro Tyr Thr Lys Ile Pro Ala Lys Thr Ala Ile Ile Pro Phe 
1               5                   10                  15      

Ile Ser Ala Gln Asp Phe Asn Gln Ala Gln Arg Leu Ser Gly 
            20                  25                  30  

<210>   167
<211>   279
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   167
Met Gly Ile Ala Leu Glu Asn Val Asn Phe Ile Tyr Gln Glu Gly Thr 
1               5                   10                  15      

Pro Leu Ala Ser Ala Ala Leu Ser Asp Val Ser Leu Thr Ile Glu Asp 
            20                  25                  30          

Gly Ser Tyr Thr Ala Leu Ile Gly His Thr Gly Ser Gly Lys Ser Thr 
        35                  40                  45              

Ile Leu Gln Leu Leu Asn Gly Leu Leu Val Pro Ser Gln Gly Ser Val 
    50                  55                  60                  

Arg Val Phe Asp Thr Leu Ile Thr Ser Thr Ser Lys Asn Lys Asp Ile 
65                  70                  75                  80  

Arg Gln Ile Arg Lys Gln Val Gly Leu Val Phe Gln Phe Ala Glu Asn 
                85                  90                  95      

Gln Ile Phe Glu Glu Thr Val Leu Lys Asp Val Ala Phe Gly Pro Gln 
            100                 105                 110         

Asn Phe Gly Val Ser Glu Glu Asp Ala Val Lys Thr Ala Arg Glu Lys 
        115                 120                 125             

Leu Ala Leu Val Gly Ile Asp Glu Ser Leu Phe Asp Arg Ser Pro Phe 
    130                 135                 140                 

Glu Leu Ser Gly Gly Gln Met Arg Arg Val Ala Ile Ala Gly Ile Leu 
145                 150                 155                 160 

Ala Met Glu Pro Ser Ile Leu Val Leu Asp Glu Pro Thr Ala Gly Leu 
                165                 170                 175     

Asp Pro Leu Gly Arg Lys Glu Leu Met Thr Leu Phe Lys Lys Leu His 
            180                 185                 190         

Gln Ser Gly Met Thr Ile Val Leu Val Thr His Leu Met Asp Asp Val 
        195                 200                 205             

Ala Glu Tyr Ala Asn Gln Val Tyr Val Met Glu Lys Gly Arg Leu Val 
    210                 215                 220                 

Lys Gly Gly Lys Pro Ser Asp Val Phe Gln Asp Val Val Phe Met Glu 
225                 230                 235                 240 

Glu Val Gln Leu Gly Val Pro Lys Ile Thr Ala Phe Cys Lys Arg Leu 
                245                 250                 255     

Ala Asp Arg Gly Val Ser Phe Lys Arg Leu Pro Ile Lys Ile Glu Glu 
            260                 265                 270         

Phe Lys Glu Ser Leu Asn Gly 
        275                 

<210>   168
<211>   132
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   168
Met Val Met Thr Asp Pro Ile Ala Asp Phe Leu Thr Arg Ile Arg Asn 
1               5                   10                  15      

Ala Asn Gln Ala Lys His Glu Val Leu Glu Val Pro Ala Ser Asn Ile 
            20                  25                  30          

Lys Lys Gly Ile Ala Glu Ile Leu Lys Arg Glu Gly Phe Val Lys Asn 
        35                  40                  45              

Val Glu Ile Ile Glu Asp Asp Lys Gln Gly Val Ile Arg Val Phe Leu 
    50                  55                  60                  

Lys Tyr Gly Pro Asn Gly Glu Lys Val Ile Thr Asn Leu Lys Arg Val 
65                  70                  75                  80  

Ser Lys Pro Gly Leu Arg Val Tyr Lys Lys Arg Glu Asp Leu Pro Lys 
                85                  90                  95      

Val Leu Asn Gly Leu Gly Ile Ala Ile Leu Ser Thr Ser Glu Gly Leu 
            100                 105                 110         

Leu Thr Asp Lys Glu Ala Arg Gln Lys Asn Val Gly Gly Glu Val Ile 
        115                 120                 125             

Ala Tyr Val Trp 
    130         

<210>   169
<211>   471
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   169
Met Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp 
1               5                   10                  15      

Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe 
            20                  25                  30          

Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg 
        35                  40                  45              

Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala 
    50                  55                  60                  

Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
65                  70                  75                  80  

Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
                85                  90                  95      

Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
            100                 105                 110         

Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
        115                 120                 125             

Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
    130                 135                 140                 

Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln 
145                 150                 155                 160 

Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
                165                 170                 175     

Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
            180                 185                 190         

Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
        195                 200                 205             

Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
    210                 215                 220                 

Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val 
225                 230                 235                 240 

Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
                245                 250                 255     

Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val 
            260                 265                 270         

Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys 
        275                 280                 285             

Ala Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr 
    290                 295                 300                 

Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe 
305                 310                 315                 320 

Thr Ala Asp His Leu Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu 
                325                 330                 335     

Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu 
            340                 345                 350         

Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser 
        355                 360                 365             

Gly Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr 
    370                 375                 380                 

Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn 
385                 390                 395                 400 

Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly 
                405                 410                 415     

Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala 
            420                 425                 430         

Trp Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val 
        435                 440                 445             

Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gln Val 
    450                 455                 460                 

Glu Asp Lys Val Glu Asn Asp 
465                 470     

<210>   170
<211>   464
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   170
Met Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp 
1               5                   10                  15      

Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe 
            20                  25                  30          

Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg 
        35                  40                  45              

Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala 
    50                  55                  60                  

Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
65                  70                  75                  80  

Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
                85                  90                  95      

Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
            100                 105                 110         

Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
        115                 120                 125             

Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
    130                 135                 140                 

Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln 
145                 150                 155                 160 

Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
                165                 170                 175     

Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
            180                 185                 190         

Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
        195                 200                 205             

Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
    210                 215                 220                 

Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val 
225                 230                 235                 240 

Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
                245                 250                 255     

Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val 
            260                 265                 270         

Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys 
        275                 280                 285             

Ala Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr 
    290                 295                 300                 

Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe 
305                 310                 315                 320 

Thr Ala Asp His Leu Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu 
                325                 330                 335     

Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu 
            340                 345                 350         

Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser 
        355                 360                 365             

Gly Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr 
    370                 375                 380                 

Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn 
385                 390                 395                 400 

Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly 
                405                 410                 415     

Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala 
            420                 425                 430         

Trp Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val 
        435                 440                 445             

Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gln Val 
    450                 455                 460                 


<210>   171
<211>   471
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   171
Met Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp 
1               5                   10                  15      

Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe 
            20                  25                  30          

Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg 
        35                  40                  45              

Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala 
    50                  55                  60                  

Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
65                  70                  75                  80  

Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
                85                  90                  95      

Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
            100                 105                 110         

Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
        115                 120                 125             

Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
    130                 135                 140                 

Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln 
145                 150                 155                 160 

Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
                165                 170                 175     

Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
            180                 185                 190         

Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
        195                 200                 205             

Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
    210                 215                 220                 

Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val 
225                 230                 235                 240 

Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
                245                 250                 255     

Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val 
            260                 265                 270         

Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys 
        275                 280                 285             

Ala Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr 
    290                 295                 300                 

Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe 
305                 310                 315                 320 

Thr Ala Asp His Leu Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu 
                325                 330                 335     

Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu 
            340                 345                 350         

Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser 
        355                 360                 365             

Gly Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr 
    370                 375                 380                 

Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn 
385                 390                 395                 400 

Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly 
                405                 410                 415     

Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala 
            420                 425                 430         

Phe Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val 
        435                 440                 445             

Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gln Val 
    450                 455                 460                 

Glu Asp Lys Val Glu Asn Asp 
465                 470     

<210>   172
<211>   886
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   172
Met Lys Lys Val Arg Lys Ile Phe Gln Lys Ala Val Ala Gly Leu Cys 
1               5                   10                  15      

Cys Ile Ser Gln Leu Thr Ala Phe Ser Ser Ile Val Ala Leu Ala Glu 
            20                  25                  30          

Thr Pro Glu Thr Ser Pro Ala Ile Gly Lys Val Val Ile Lys Glu Thr 
        35                  40                  45              

Gly Glu Gly Gly Ala Leu Leu Gly Asp Ala Val Phe Glu Leu Lys Asn 
    50                  55                  60                  

Asn Thr Asp Gly Thr Thr Val Ser Gln Arg Thr Glu Ala Gln Thr Gly 
65                  70                  75                  80  

Glu Ala Ile Phe Ser Asn Ile Lys Pro Gly Thr Tyr Thr Leu Thr Glu 
                85                  90                  95      

Ala Gln Pro Pro Val Gly Tyr Lys Pro Ser Thr Lys Gln Trp Thr Val 
            100                 105                 110         

Glu Val Glu Lys Asn Gly Arg Thr Thr Val Gln Gly Glu Gln Val Glu 
        115                 120                 125             

Asn Arg Glu Glu Ala Leu Ser Asp Gln Tyr Pro Gln Thr Gly Thr Tyr 
    130                 135                 140                 

Pro Asp Val Gln Thr Pro Tyr Gln Ile Ile Lys Val Asp Gly Ser Glu 
145                 150                 155                 160 

Lys Asn Gly Gln His Lys Ala Leu Asn Pro Asn Pro Tyr Glu Arg Val 
                165                 170                 175     

Ile Pro Glu Gly Thr Leu Ser Lys Arg Ile Tyr Gln Val Asn Asn Leu 
            180                 185                 190         

Asp Asp Asn Gln Tyr Gly Ile Glu Leu Thr Val Ser Gly Lys Thr Val 
        195                 200                 205             

Tyr Glu Gln Lys Asp Lys Ser Val Pro Leu Asp Val Val Ile Leu Leu 
    210                 215                 220                 

Asp Asn Ser Asn Ser Met Ser Asn Ile Arg Asn Lys Asn Ala Arg Arg 
225                 230                 235                 240 

Ala Glu Arg Ala Gly Glu Ala Thr Arg Ser Leu Ile Asp Lys Ile Thr 
                245                 250                 255     

Ser Asp Ser Glu Asn Arg Val Ala Leu Val Thr Tyr Ala Ser Thr Ile 
            260                 265                 270         

Phe Asp Gly Thr Glu Phe Thr Val Glu Lys Gly Val Ala Asp Lys Asn 
        275                 280                 285             

Gly Lys Arg Leu Asn Asp Ser Leu Phe Trp Asn Tyr Asp Gln Thr Ser 
    290                 295                 300                 

Phe Thr Thr Asn Thr Lys Asp Tyr Ser Tyr Leu Lys Leu Thr Asn Asp 
305                 310                 315                 320 

Lys Asn Asp Ile Val Glu Leu Lys Asn Lys Val Pro Thr Glu Ala Glu 
                325                 330                 335     

Asp His Asp Gly Asn Arg Leu Met Tyr Gln Phe Gly Ala Thr Phe Thr 
            340                 345                 350         

Gln Lys Ala Leu Met Lys Ala Asp Glu Ile Leu Thr Gln Gln Ala Arg 
        355                 360                 365             

Gln Asn Ser Gln Lys Val Ile Phe His Ile Thr Asp Gly Val Pro Thr 
    370                 375                 380                 

Met Ser Tyr Pro Ile Asn Phe Asn His Ala Thr Phe Ala Pro Ser Tyr 
385                 390                 395                 400 

Gln Asn Gln Leu Asn Ala Phe Phe Ser Lys Ser Pro Asn Lys Asp Gly 
                405                 410                 415     

Ile Leu Leu Ser Asp Phe Ile Thr Gln Ala Thr Ser Gly Glu His Thr 
            420                 425                 430         

Ile Val Arg Gly Asp Gly Gln Ser Tyr Gln Met Phe Thr Asp Lys Thr 
        435                 440                 445             

Val Tyr Glu Lys Gly Ala Pro Ala Ala Phe Pro Val Lys Pro Glu Lys 
    450                 455                 460                 

Tyr Ser Glu Met Lys Ala Ala Gly Tyr Ala Val Ile Gly Asp Pro Ile 
465                 470                 475                 480 

Asn Gly Gly Tyr Ile Trp Leu Asn Trp Arg Glu Ser Ile Leu Ala Tyr 
                485                 490                 495     

Pro Phe Asn Ser Asn Thr Ala Lys Ile Thr Asn His Gly Asp Pro Thr 
            500                 505                 510         

Arg Trp Tyr Tyr Asn Gly Asn Ile Ala Pro Asp Gly Tyr Asp Val Phe 
        515                 520                 525             

Thr Val Gly Ile Gly Ile Asn Gly Asp Pro Gly Thr Asp Glu Ala Thr 
    530                 535                 540                 

Ala Thr Ser Phe Met Gln Ser Ile Ser Ser Lys Pro Glu Asn Tyr Thr 
545                 550                 555                 560 

Asn Val Thr Asp Thr Thr Lys Ile Leu Glu Gln Leu Asn Arg Tyr Phe 
                565                 570                 575     

His Thr Ile Val Thr Glu Lys Lys Ser Ile Glu Asn Gly Thr Ile Thr 
            580                 585                 590         

Asp Pro Met Gly Glu Leu Ile Asp Leu Gln Leu Gly Thr Asp Gly Arg 
        595                 600                 605             

Phe Asp Pro Ala Asp Tyr Thr Leu Thr Ala Asn Asp Gly Ser Arg Leu 
    610                 615                 620                 

Glu Asn Gly Gln Ala Val Gly Gly Pro Gln Asn Asp Gly Gly Leu Leu 
625                 630                 635                 640 

Lys Asn Ala Lys Val Leu Tyr Asp Thr Thr Glu Lys Arg Ile Arg Val 
                645                 650                 655     

Thr Gly Leu Tyr Leu Gly Thr Asp Glu Lys Val Thr Leu Thr Tyr Asn 
            660                 665                 670         

Val Arg Leu Asn Asp Glu Phe Val Ser Asn Lys Phe Tyr Asp Thr Asn 
        675                 680                 685             

Gly Arg Thr Thr Leu His Pro Lys Glu Val Glu Gln Asn Thr Val Arg 
    690                 695                 700                 

Asp Phe Pro Ile Pro Lys Ile Arg Asp Val Arg Lys Tyr Pro Glu Ile 
705                 710                 715                 720 

Thr Ile Ser Lys Glu Lys Lys Leu Gly Asp Ile Glu Phe Ile Lys Val 
                725                 730                 735     

Asn Lys Asn Asp Lys Lys Pro Leu Arg Gly Ala Val Phe Ser Leu Gln 
            740                 745                 750         

Lys Gln His Pro Asp Tyr Pro Asp Ile Tyr Gly Ala Ile Asp Gln Asn 
        755                 760                 765             

Gly Thr Tyr Gln Asn Val Arg Thr Gly Glu Asp Gly Lys Leu Thr Phe 
    770                 775                 780                 

Lys Asn Leu Ser Asp Gly Lys Tyr Arg Leu Phe Glu Asn Ser Glu Pro 
785                 790                 795                 800 

Ala Gly Tyr Lys Pro Val Gln Asn Lys Pro Ile Val Ala Phe Gln Ile 
                805                 810                 815     

Val Asn Gly Glu Val Arg Asp Val Thr Ser Ile Val Pro Gln Asp Ile 
            820                 825                 830         

Pro Ala Gly Tyr Glu Phe Thr Asn Asp Lys His Tyr Ile Thr Asn Glu 
        835                 840                 845             

Pro Ile Pro Pro Lys Arg Glu Tyr Pro Arg Thr Gly Gly Ile Gly Met 
    850                 855                 860                 

Leu Pro Phe Tyr Leu Ile Gly Cys Met Met Met Gly Gly Val Leu Leu 
865                 870                 875                 880 

Tyr Thr Arg Lys His Pro 
                885     

<210>   173
<211>   665
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   173
Met Lys Ser Ile Asn Lys Phe Leu Thr Met Leu Ala Ala Leu Leu Leu 
1               5                   10                  15      

Thr Ala Ser Ser Leu Phe Ser Ala Ala Thr Val Phe Ala Ala Gly Thr 
            20                  25                  30          

Thr Thr Thr Ser Val Thr Val His Lys Leu Leu Ala Thr Asp Gly Asp 
        35                  40                  45              

Met Asp Lys Ile Ala Asn Glu Leu Glu Thr Gly Asn Tyr Ala Gly Asn 
    50                  55                  60                  

Lys Val Gly Val Leu Pro Ala Asn Ala Lys Glu Ile Ala Gly Val Met 
65                  70                  75                  80  

Phe Val Trp Thr Asn Thr Asn Asn Glu Ile Ile Asp Glu Asn Gly Gln 
                85                  90                  95      

Thr Leu Gly Val Asn Ile Asp Pro Gln Thr Phe Lys Leu Ser Gly Ala 
            100                 105                 110         

Met Pro Ala Thr Ala Met Lys Lys Leu Thr Glu Ala Glu Gly Ala Lys 
        115                 120                 125             

Phe Asn Thr Ala Asn Leu Pro Ala Ala Lys Tyr Lys Ile Tyr Glu Ile 
    130                 135                 140                 

His Ser Leu Ser Thr Tyr Val Gly Glu Asp Gly Ala Thr Leu Thr Gly 
145                 150                 155                 160 

Ser Lys Ala Val Pro Ile Glu Ile Glu Leu Pro Leu Asn Asp Val Val 
                165                 170                 175     

Asp Ala His Val Tyr Pro Lys Asn Thr Glu Ala Lys Pro Lys Ile Asp 
            180                 185                 190         

Lys Asp Phe Lys Gly Lys Ala Asn Pro Asp Thr Pro Arg Val Asp Lys 
        195                 200                 205             

Asp Thr Pro Val Asn His Gln Val Gly Asp Val Val Glu Tyr Glu Ile 
    210                 215                 220                 

Val Thr Lys Ile Pro Ala Leu Ala Asn Tyr Ala Thr Ala Asn Trp Ser 
225                 230                 235                 240 

Asp Arg Met Thr Glu Gly Leu Ala Phe Asn Lys Gly Thr Val Lys Val 
                245                 250                 255     

Thr Val Asp Asp Val Ala Leu Glu Ala Gly Asp Tyr Ala Leu Thr Glu 
            260                 265                 270         

Val Ala Thr Gly Phe Asp Leu Lys Leu Thr Asp Ala Gly Leu Ala Lys 
        275                 280                 285             

Val Asn Asp Gln Asn Ala Glu Lys Thr Val Lys Ile Thr Tyr Ser Ala 
    290                 295                 300                 

Thr Leu Asn Asp Lys Ala Ile Val Glu Val Pro Glu Ser Asn Asp Val 
305                 310                 315                 320 

Thr Phe Asn Tyr Gly Asn Asn Pro Asp His Gly Asn Thr Pro Lys Pro 
                325                 330                 335     

Asn Lys Pro Asn Glu Asn Gly Asp Leu Thr Leu Thr Lys Thr Trp Val 
            340                 345                 350         

Asp Ala Thr Gly Ala Pro Ile Pro Ala Gly Ala Glu Ala Thr Phe Asp 
        355                 360                 365             

Leu Val Asn Ala Gln Thr Gly Lys Val Val Gln Thr Val Thr Leu Thr 
    370                 375                 380                 

Thr Asp Lys Asn Thr Val Thr Val Asn Gly Leu Asp Lys Asn Thr Glu 
385                 390                 395                 400 

Tyr Lys Phe Val Glu Arg Ser Ile Lys Gly Tyr Ser Ala Asp Tyr Gln 
                405                 410                 415     

Glu Ile Thr Thr Ala Gly Glu Ile Ala Val Lys Asn Trp Lys Asp Glu 
            420                 425                 430         

Asn Pro Lys Pro Leu Asp Pro Thr Glu Pro Lys Val Val Thr Tyr Gly 
        435                 440                 445             

Lys Lys Phe Val Lys Val Asn Asp Lys Asp Asn Arg Leu Ala Gly Ala 
    450                 455                 460                 

Glu Phe Val Ile Ala Asn Ala Asp Asn Ala Gly Gln Tyr Leu Ala Arg 
465                 470                 475                 480 

Lys Ala Asp Lys Val Ser Gln Glu Glu Lys Gln Leu Val Val Thr Thr 
                485                 490                 495     

Lys Asp Ala Leu Asp Arg Ala Val Ala Ala Tyr Asn Ala Leu Thr Ala 
            500                 505                 510         

Gln Gln Gln Thr Gln Gln Glu Lys Glu Lys Val Asp Lys Ala Gln Ala 
        515                 520                 525             

Ala Tyr Asn Ala Ala Val Ile Ala Ala Asn Asn Ala Phe Glu Trp Val 
    530                 535                 540                 

Ala Asp Lys Asp Asn Glu Asn Val Val Lys Leu Val Ser Asp Ala Gln 
545                 550                 555                 560 

Gly Arg Phe Glu Ile Thr Gly Leu Leu Ala Gly Thr Tyr Tyr Leu Glu 
                565                 570                 575     

Glu Thr Lys Gln Pro Ala Gly Tyr Ala Leu Leu Thr Ser Arg Gln Lys 
            580                 585                 590         

Phe Glu Val Thr Ala Thr Ser Tyr Ser Ala Thr Gly Gln Gly Ile Glu 
        595                 600                 605             

Tyr Thr Ala Gly Ser Gly Lys Asp Asp Ala Thr Lys Val Val Asn Lys 
    610                 615                 620                 

Lys Ile Thr Ile Pro Gln Thr Gly Gly Ile Gly Thr Ile Ile Phe Ala 
625                 630                 635                 640 

Val Ala Gly Ala Ala Ile Met Gly Ile Ala Val Tyr Ala Tyr Val Lys 
                645                 650                 655     

Asn Asn Lys Asp Glu Asp Gln Leu Ala 
            660                 665 

<210>   174
<211>   644
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   174
Met Lys Ser Ile Asn Lys Phe Leu Thr Met Leu Ala Ala Leu Leu Leu 
1               5                   10                  15      

Thr Ala Ser Ser Leu Phe Ser Ala Ala Thr Val Phe Ala Ala Asp Asn 
            20                  25                  30          

Val Ser Thr Ala Pro Asp Ala Val Thr Lys Thr Leu Thr Ile His Lys 
        35                  40                  45              

Leu Leu Leu Ser Glu Asp Asp Leu Lys Thr Trp Asp Thr Asn Gly Pro 
    50                  55                  60                  

Lys Gly Tyr Asp Gly Thr Gln Ser Ser Leu Lys Asp Leu Thr Gly Val 
65                  70                  75                  80  

Val Ala Glu Glu Ile Pro Asn Val Tyr Phe Glu Leu Gln Lys Tyr Asn 
                85                  90                  95      

Leu Thr Asp Gly Lys Glu Lys Glu Asn Leu Lys Asp Asp Ser Lys Trp 
            100                 105                 110         

Thr Thr Val His Gly Gly Leu Thr Thr Lys Asp Gly Leu Lys Ile Glu 
        115                 120                 125             

Thr Ser Thr Leu Lys Gly Val Tyr Arg Ile Arg Glu Asp Arg Thr Lys 
    130                 135                 140                 

Thr Thr Tyr Val Gly Pro Asn Gly Gln Val Leu Thr Gly Ser Lys Ala 
145                 150                 155                 160 

Val Pro Ala Leu Val Thr Leu Pro Leu Val Asn Asn Asn Gly Thr Val 
                165                 170                 175     

Ile Asp Ala His Val Phe Pro Lys Asn Ser Tyr Asn Lys Pro Val Val 
            180                 185                 190         

Asp Lys Arg Ile Ala Asp Thr Leu Asn Tyr Asn Asp Gln Asn Gly Leu 
        195                 200                 205             

Ser Ile Gly Thr Lys Ile Pro Tyr Val Val Asn Thr Thr Ile Pro Ser 
    210                 215                 220                 

Asn Ala Thr Phe Ala Thr Ser Phe Trp Ser Asp Glu Met Thr Glu Gly 
225                 230                 235                 240 

Leu Thr Tyr Asn Glu Asp Val Thr Ile Thr Leu Asn Asn Val Ala Met 
                245                 250                 255     

Asp Gln Ala Asp Tyr Glu Val Thr Lys Gly Asn Asn Gly Phe Asn Leu 
            260                 265                 270         

Lys Leu Thr Glu Ala Gly Leu Ala Lys Ile Asn Gly Lys Asp Ala Asp 
        275                 280                 285             

Gln Lys Ile Gln Ile Thr Tyr Ser Ala Thr Leu Asn Ser Leu Ala Val 
    290                 295                 300                 

Ala Asp Ile Pro Glu Ser Asn Asp Ile Thr Tyr His Tyr Gly Asn His 
305                 310                 315                 320 

Gln Asp His Gly Asn Thr Pro Lys Pro Thr Lys Pro Asn Asn Gly Gln 
                325                 330                 335     

Ile Thr Val Thr Lys Thr Trp Asp Ser Gln Pro Ala Pro Glu Gly Val 
            340                 345                 350         

Lys Ala Thr Val Gln Leu Val Asn Ala Lys Thr Gly Glu Lys Val Gly 
        355                 360                 365             

Ala Pro Val Glu Leu Ser Glu Asn Asn Trp Thr Tyr Thr Trp Ser Gly 
    370                 375                 380                 

Leu Asp Asn Ser Ile Glu Tyr Lys Val Glu Glu Glu Tyr Asn Gly Tyr 
385                 390                 395                 400 

Ser Ala Glu Tyr Thr Val Glu Ser Lys Gly Lys Leu Gly Val Lys Asn 
                405                 410                 415     

Trp Lys Asp Asn Asn Pro Ala Pro Ile Asn Pro Glu Glu Pro Arg Val 
            420                 425                 430         

Lys Thr Tyr Gly Lys Lys Phe Val Lys Val Asp Gln Lys Asp Thr Arg 
        435                 440                 445             

Leu Glu Asn Ala Gln Phe Val Val Lys Lys Ala Asp Ser Asn Lys Tyr 
    450                 455                 460                 

Ile Ala Phe Lys Ser Thr Ala Gln Gln Ala Ala Asp Glu Lys Ala Ala 
465                 470                 475                 480 

Ala Thr Ala Lys Gln Lys Leu Asp Ala Ala Val Ala Ala Tyr Thr Asn 
                485                 490                 495     

Ala Ala Asp Lys Gln Ala Ala Gln Ala Leu Val Asp Gln Ala Gln Gln 
            500                 505                 510         

Glu Tyr Asn Val Ala Tyr Lys Glu Ala Lys Phe Gly Tyr Val Glu Val 
        515                 520                 525             

Ala Gly Lys Asp Glu Ala Met Val Leu Thr Ser Asn Thr Asp Gly Gln 
    530                 535                 540                 

Phe Gln Ile Ser Gly Leu Ala Ala Gly Thr Tyr Lys Leu Glu Glu Ile 
545                 550                 555                 560 

Lys Ala Pro Glu Gly Phe Ala Lys Ile Asp Asp Val Glu Phe Val Val 
                565                 570                 575     

Gly Ala Gly Ser Trp Asn Gln Gly Glu Phe Asn Tyr Leu Lys Asp Val 
            580                 585                 590         

Gln Lys Asn Asp Ala Thr Lys Val Val Asn Lys Lys Ile Thr Ile Pro 
        595                 600                 605             

Gln Thr Gly Gly Ile Gly Thr Ile Ile Phe Ala Val Ala Gly Ala Ala 
    610                 615                 620                 

Ile Met Gly Ile Ala Val Tyr Ala Tyr Val Lys Asn Asn Lys Asp Glu 
625                 630                 635                 640 

Asp Gln Leu Ala 
                

<210>   175
<211>   654
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   175
Met Lys Ser Ile Asn Lys Phe Leu Thr Ile Leu Ala Ala Leu Leu Leu 
1               5                   10                  15      

Thr Val Ser Ser Leu Phe Ser Ala Ala Thr Val Phe Ala Ala Glu Gln 
            20                  25                  30          

Lys Thr Lys Thr Leu Thr Val His Lys Leu Leu Met Thr Asp Gln Glu 
        35                  40                  45              

Leu Asp Ala Trp Asn Ser Asp Ala Ile Thr Thr Ala Gly Tyr Asp Gly 
    50                  55                  60                  

Ser Gln Asn Phe Glu Gln Phe Lys Gln Leu Gln Gly Val Pro Gln Gly 
65                  70                  75                  80  

Val Thr Glu Ile Ser Gly Val Ala Phe Glu Leu Gln Ser Tyr Thr Gly 
                85                  90                  95      

Pro Gln Gly Lys Glu Gln Glu Asn Leu Thr Asn Asp Ala Val Trp Thr 
            100                 105                 110         

Ala Val Asn Lys Gly Val Thr Thr Glu Thr Gly Val Lys Phe Asp Thr 
        115                 120                 125             

Glu Val Leu Gln Gly Thr Tyr Arg Leu Val Glu Val Arg Lys Glu Ser 
    130                 135                 140                 

Thr Tyr Val Gly Pro Asn Gly Lys Val Leu Thr Gly Met Lys Ala Val 
145                 150                 155                 160 

Pro Ala Leu Ile Thr Leu Pro Leu Val Asn Gln Asn Gly Val Val Glu 
                165                 170                 175     

Asn Ala His Val Tyr Pro Lys Asn Ser Glu Asp Lys Pro Thr Ala Thr 
            180                 185                 190         

Lys Thr Phe Asp Thr Ala Ala Gly Phe Val Asp Pro Gly Glu Lys Gly 
        195                 200                 205             

Leu Ala Ile Gly Thr Lys Val Pro Tyr Ile Val Thr Thr Thr Ile Pro 
    210                 215                 220                 

Lys Asn Ser Thr Leu Ala Thr Ala Phe Trp Ser Asp Glu Met Thr Glu 
225                 230                 235                 240 

Gly Leu Asp Tyr Asn Gly Asp Val Val Val Asn Tyr Asn Gly Gln Pro 
                245                 250                 255     

Leu Asp Asn Ser His Tyr Thr Leu Glu Ala Gly His Asn Gly Phe Ile 
            260                 265                 270         

Leu Lys Leu Asn Glu Lys Gly Leu Glu Ala Ile Asn Gly Lys Asp Ala 
        275                 280                 285             

Glu Ala Thr Ile Thr Leu Lys Tyr Thr Ala Thr Leu Asn Ala Leu Ala 
    290                 295                 300                 

Val Ala Asp Val Pro Glu Ala Asn Asp Val Thr Phe His Tyr Gly Asn 
305                 310                 315                 320 

Asn Pro Gly His Gly Asn Thr Pro Lys Pro Asn Lys Pro Lys Asn Gly 
                325                 330                 335     

Glu Leu Thr Ile Thr Lys Thr Trp Ala Asp Ala Lys Asp Ala Pro Ile 
            340                 345                 350         

Ala Gly Val Glu Val Thr Phe Asp Leu Val Asn Ala Gln Thr Gly Glu 
        355                 360                 365             

Val Val Lys Val Pro Gly His Glu Thr Gly Ile Val Leu Asn Gln Thr 
    370                 375                 380                 

Asn Asn Trp Thr Phe Thr Ala Thr Gly Leu Asp Asn Asn Thr Glu Tyr 
385                 390                 395                 400 

Lys Phe Val Glu Arg Thr Ile Lys Gly Tyr Ser Ala Asp Tyr Gln Thr 
                405                 410                 415     

Ile Thr Glu Thr Gly Lys Ile Ala Val Lys Asn Trp Lys Asp Glu Asn 
            420                 425                 430         

Pro Glu Pro Ile Asn Pro Glu Glu Pro Arg Val Lys Thr Tyr Gly Lys 
        435                 440                 445             

Lys Phe Val Lys Val Asp Gln Lys Asp Glu Arg Leu Lys Glu Ala Gln 
    450                 455                 460                 

Phe Val Val Lys Asn Glu Gln Gly Lys Tyr Leu Ala Leu Lys Ser Ala 
465                 470                 475                 480 

Ala Gln Gln Ala Val Asn Glu Lys Ala Ala Ala Glu Ala Lys Gln Ala 
                485                 490                 495     

Leu Asp Ala Ala Ile Ala Ala Tyr Thr Asn Ala Ala Asp Lys Asn Ala 
            500                 505                 510         

Ala Gln Ala Val Val Asp Ala Ala Gln Lys Thr Tyr Asn Asp Asn Tyr 
        515                 520                 525             

Arg Ala Ala Arg Phe Gly Tyr Val Glu Val Glu Arg Lys Glu Asp Ala 
    530                 535                 540                 

Leu Val Leu Thr Ser Asn Thr Asp Gly Gln Phe Gln Ile Ser Gly Leu 
545                 550                 555                 560 

Ala Ala Gly Ser Tyr Thr Leu Glu Glu Thr Lys Ala Pro Glu Gly Phe 
                565                 570                 575     

Ala Lys Leu Gly Asp Val Lys Phe Glu Val Gly Ala Gly Ser Trp Asn 
            580                 585                 590         

Gln Gly Asp Phe Asn Tyr Leu Lys Asp Val Gln Lys Asn Asp Ala Thr 
        595                 600                 605             

Lys Val Val Asn Lys Lys Ile Thr Ile Pro Gln Thr Gly Gly Ile Gly 
    610                 615                 620                 

Thr Ile Ile Phe Ala Val Ala Gly Ala Val Ile Met Gly Ile Ala Val 
625                 630                 635                 640 

Tyr Ala Tyr Val Lys Asn Asn Lys Asp Glu Asp Gln Leu Ala 
                645                 650                 

<210>   176
<211>   401
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   176
Met Thr Met Gln Lys Met Gln Lys Met Ile Ser Arg Ile Phe Phe Val 
1               5                   10                  15      

Met Ala Leu Cys Phe Ser Leu Val Trp Gly Ala His Ala Val Gln Ala 
            20                  25                  30          

Gln Glu Asp His Thr Leu Val Leu Gln Leu Glu Asn Tyr Gln Glu Val 
        35                  40                  45              

Val Ser Gln Leu Pro Ser Arg Asp Gly His Arg Leu Gln Val Trp Lys 
    50                  55                  60                  

Leu Asp Asp Ser Tyr Ser Tyr Asp Asp Arg Val Gln Ile Val Arg Asp 
65                  70                  75                  80  

Leu His Ser Trp Asp Glu Asn Lys Leu Ser Ser Phe Lys Lys Thr Ser 
                85                  90                  95      

Phe Glu Met Thr Phe Leu Glu Asn Gln Ile Glu Val Ser His Ile Pro 
            100                 105                 110         

Asn Gly Leu Tyr Tyr Val Arg Ser Ile Ile Gln Thr Asp Ala Val Ser 
        115                 120                 125             

Tyr Pro Ala Glu Phe Leu Phe Glu Met Thr Asp Gln Thr Val Glu Pro 
    130                 135                 140                 

Leu Val Ile Val Ala Lys Lys Thr Asp Thr Met Thr Thr Lys Val Lys 
145                 150                 155                 160 

Leu Ile Lys Val Asp Gln Asp His Asn Arg Leu Glu Gly Val Gly Phe 
                165                 170                 175     

Lys Leu Val Ser Val Ala Arg Asp Val Ser Glu Lys Glu Val Pro Leu 
            180                 185                 190         

Ile Gly Glu Tyr Arg Tyr Ser Ser Ser Gly Gln Val Gly Arg Thr Leu 
        195                 200                 205             

Tyr Thr Asp Lys Asn Gly Glu Ile Phe Val Thr Asn Leu Pro Leu Gly 
    210                 215                 220                 

Asn Tyr Arg Phe Lys Glu Val Glu Pro Leu Ala Gly Tyr Ala Val Thr 
225                 230                 235                 240 

Thr Leu Asp Thr Asp Val Gln Leu Val Asp His Gln Leu Val Thr Ile 
                245                 250                 255     

Thr Val Val Asn Gln Lys Leu Pro Arg Gly Asn Val Asp Phe Met Lys 
            260                 265                 270         

Val Asp Gly Arg Thr Asn Thr Ser Leu Gln Gly Ala Met Phe Lys Val 
        275                 280                 285             

Met Lys Glu Glu Ser Gly His Tyr Thr Pro Val Leu Gln Asn Gly Lys 
    290                 295                 300                 

Glu Val Val Val Thr Ser Gly Lys Asp Gly Arg Phe Arg Val Glu Gly 
305                 310                 315                 320 

Leu Glu Tyr Gly Thr Tyr Tyr Leu Trp Glu Leu Gln Ala Pro Thr Gly 
                325                 330                 335     

Tyr Val Gln Leu Thr Ser Pro Val Ser Phe Thr Ile Gly Lys Asp Thr 
            340                 345                 350         

Arg Lys Glu Leu Val Thr Val Val Lys Asn Asn Lys Arg Pro Arg Ile 
        355                 360                 365             

Asp Val Pro Asp Thr Gly Glu Glu Thr Leu Tyr Ile Leu Met Leu Val 
    370                 375                 380                 

Ala Ile Leu Leu Phe Gly Ser Gly Tyr Tyr Leu Thr Lys Lys Pro Asn 
385                 390                 395                 400 

Asn 
    

<210>   177
<211>   1063
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   177
Asp Glu Thr Leu Ile Thr His Thr Ala Glu Lys Pro Lys Glu Glu Lys 
1               5                   10                  15      

Met Ile Val Glu Glu Lys Ala Asp Lys Ala Leu Glu Thr Lys Asn Val 
            20                  25                  30          

Val Glu Arg Thr Glu Gln Ser Glu Pro Ser Ser Thr Glu Ala Ile Ala 
        35                  40                  45              

Ser Glu Lys Lys Glu Asp Glu Ala Val Thr Pro Lys Glu Glu Lys Val 
    50                  55                  60                  

Ser Ala Lys Pro Glu Glu Lys Ala Pro Arg Ile Glu Ser Gln Ala Ser 
65                  70                  75                  80  

Ser Gln Glu Lys Pro Leu Lys Glu Asp Ala Lys Ala Val Thr Asn Glu 
                85                  90                  95      

Glu Val Asn Gln Met Ile Glu Asn Arg Lys Val Asp Phe Asn Gln Asn 
            100                 105                 110         

Trp Tyr Phe Lys Leu Asn Ala Asn Ser Lys Glu Ala Ile Lys Pro Asp 
        115                 120                 125             

Ala Asp Val Ser Thr Trp Lys Lys Leu Asp Leu Pro Tyr Asp Trp Ser 
    130                 135                 140                 

Ile Phe Asn Asp Phe Asp His Glu Ser Pro Ala Gln Asn Glu Gly Gly 
145                 150                 155                 160 

Gln Leu Asn Gly Gly Glu Ala Trp Tyr Arg Lys Thr Phe Lys Leu Asp 
                165                 170                 175     

Glu Lys Asp Leu Lys Lys Asn Val Arg Leu Thr Phe Asp Gly Val Tyr 
            180                 185                 190         

Met Asp Ser Gln Val Tyr Val Asn Gly Gln Leu Val Gly His Tyr Pro 
        195                 200                 205             

Asn Gly Tyr Asn Gln Phe Ser Tyr Asp Ile Thr Lys Tyr Leu Tyr Lys 
    210                 215                 220                 

Asp Gly Arg Glu Asn Val Ile Ala Val His Ala Val Asn Lys Gln Pro 
225                 230                 235                 240 

Ser Ser Arg Trp Tyr Ser Gly Ser Gly Ile Tyr Arg Asp Val Thr Leu 
                245                 250                 255     

Gln Val Thr Asp Lys Val His Val Glu Lys Asn Gly Thr Thr Ile Leu 
            260                 265                 270         

Thr Pro Lys Leu Glu Glu Gln Gln His Gly Lys Val Glu Thr His Val 
        275                 280                 285             

Thr Ser Lys Ile Val Asn Thr Asp Asp Lys Asp His Glu Leu Val Ala 
    290                 295                 300                 

Glu Tyr Gln Ile Val Glu Arg Gly Gly His Ala Val Thr Gly Leu Val 
305                 310                 315                 320 

Arg Thr Ala Ser Arg Thr Leu Lys Ala His Glu Ser Thr Ser Leu Asp 
                325                 330                 335     

Ala Ile Leu Glu Val Glu Arg Pro Lys Leu Trp Thr Val Leu Asn Asp 
            340                 345                 350         

Lys Pro Ala Leu Tyr Glu Leu Ile Thr Arg Val Tyr Arg Asp Gly Gln 
        355                 360                 365             

Leu Val Asp Ala Lys Lys Asp Leu Phe Gly Tyr Arg Tyr Tyr His Trp 
    370                 375                 380                 

Thr Pro Asn Glu Gly Phe Ser Leu Asn Gly Glu Arg Ile Lys Phe His 
385                 390                 395                 400 

Gly Val Ser Leu His His Asp His Gly Ala Leu Gly Ala Glu Glu Asn 
                405                 410                 415     

Tyr Lys Ala Glu Tyr Arg Arg Leu Lys Gln Met Lys Glu Met Gly Val 
            420                 425                 430         

Asn Ser Ile Arg Thr Thr His Asn Pro Ala Ser Glu Gln Thr Leu Gln 
        435                 440                 445             

Ile Ala Ala Glu Leu Gly Leu Leu Val Gln Glu Glu Ala Phe Asp Thr 
    450                 455                 460                 

Trp Tyr Gly Gly Lys Lys Pro Tyr Asp Tyr Gly Arg Phe Phe Glu Lys 
465                 470                 475                 480 

Asp Ala Thr His Pro Glu Ala Arg Lys Gly Glu Lys Trp Ser Asp Phe 
                485                 490                 495     

Asp Leu Arg Thr Met Val Glu Arg Gly Lys Asn Asn Pro Ala Ile Phe 
            500                 505                 510         

Met Trp Ser Ile Gly Asn Glu Ile Gly Glu Ala Asn Gly Asp Ala His 
        515                 520                 525             

Ser Leu Ala Thr Val Lys Arg Leu Val Lys Val Ile Lys Asp Val Asp 
    530                 535                 540                 

Lys Thr Arg Tyr Val Thr Met Gly Ala Asp Lys Phe Arg Phe Gly Asn 
545                 550                 555                 560 

Gly Ser Gly Gly His Glu Lys Ile Ala Asp Glu Leu Asp Ala Val Gly 
                565                 570                 575     

Phe Asn Tyr Ser Glu Asp Asn Tyr Lys Ala Leu Arg Ala Lys His Pro 
            580                 585                 590         

Lys Trp Leu Ile Tyr Gly Ser Glu Thr Ser Ser Ala Thr Arg Thr Arg 
        595                 600                 605             

Gly Ser Tyr Tyr Arg Pro Glu Arg Glu Leu Lys His Ser Asn Gly Pro 
    610                 615                 620                 

Glu Arg Asn Tyr Glu Gln Ser Asp Tyr Gly Asn Asp Arg Val Gly Trp 
625                 630                 635                 640 

Gly Lys Thr Ala Thr Ala Ser Trp Thr Phe Asp Arg Asp Asn Ala Gly 
                645                 650                 655     

Tyr Ala Gly Gln Phe Ile Trp Thr Gly Thr Asp Tyr Ile Gly Glu Pro 
            660                 665                 670         

Thr Pro Trp His Asn Gln Asn Gln Thr Pro Val Lys Ser Ser Tyr Phe 
        675                 680                 685             

Gly Ile Val Asp Thr Ala Gly Ile Pro Lys His Asp Phe Tyr Leu Tyr 
    690                 695                 700                 

Gln Ser Gln Trp Val Ser Val Lys Lys Lys Pro Met Val His Leu Leu 
705                 710                 715                 720 

Pro His Trp Asn Trp Glu Asn Lys Glu Leu Ala Ser Lys Val Ala Asp 
                725                 730                 735     

Ser Glu Gly Lys Ile Pro Val Arg Ala Tyr Ser Asn Ala Ser Ser Val 
            740                 745                 750         

Glu Leu Phe Leu Asn Gly Lys Ser Leu Gly Leu Lys Thr Phe Asn Lys 
        755                 760                 765             

Lys Gln Thr Ser Asp Gly Arg Thr Tyr Gln Glu Gly Ala Asn Ala Asn 
    770                 775                 780                 

Glu Leu Tyr Leu Glu Trp Lys Val Ala Tyr Gln Pro Gly Thr Leu Glu 
785                 790                 795                 800 

Ala Ile Ala Arg Asp Glu Ser Gly Lys Glu Ile Ala Arg Asp Lys Ile 
                805                 810                 815     

Thr Thr Ala Gly Lys Pro Ala Ala Val Arg Leu Ile Lys Glu Asp His 
            820                 825                 830         

Ala Ile Ala Ala Asp Gly Lys Asp Leu Thr Tyr Ile Tyr Tyr Glu Ile 
        835                 840                 845             

Val Asp Ser Gln Gly Asn Val Val Pro Thr Ala Asn Asn Leu Val Arg 
    850                 855                 860                 

Phe Gln Leu His Gly Gln Gly Gln Leu Val Gly Val Asp Asn Gly Glu 
865                 870                 875                 880 

Gln Ala Ser Arg Glu Arg Tyr Lys Ala Gln Ala Asp Gly Ser Trp Ile 
                885                 890                 895     

Arg Lys Ala Phe Asn Gly Lys Gly Val Ala Ile Val Lys Ser Thr Glu 
            900                 905                 910         

Gln Ala Gly Lys Phe Thr Leu Thr Ala His Ser Asp Leu Leu Lys Ser 
        915                 920                 925             

Asn Gln Val Thr Val Phe Thr Gly Lys Lys Glu Gly Gln Glu Lys Thr 
    930                 935                 940                 

Val Leu Gly Thr Glu Val Pro Lys Val Gln Thr Ile Ile Gly Glu Ala 
945                 950                 955                 960 

Pro Glu Met Pro Thr Thr Val Pro Phe Val Tyr Ser Asp Gly Ser Arg 
                965                 970                 975     

Ala Glu Arg Pro Val Thr Trp Ser Leu Val Asp Val Ser Lys Pro Gly 
            980                 985                 990         

Ile Val Thr Val Lys Gly Met Ala Asp Gly Arg Glu Val Glu Ala Arg 
        995                 1000                1005            

Val Glu Val Ile Ala Leu Lys Ser Glu Leu Pro Val Val Lys Arg Ile 
    1010                1015                1020                

Ala Pro Asn Thr Asn Leu Asn Ser Val Asp Lys Ser Val Ser Tyr Val 
1025                1030                1035                1040

Leu Thr Asp Gly Ser Val Gln Glu Tyr Glu Val Asp Lys Trp Glu Ile 
                1045                1050                1055    

Ala Glu Glu Asp Lys Ala Lys 
            1060            

<210>   178
<211>   1093
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   178
Ile Ala Glu Glu Asp Lys Ala Lys Leu Ala Ile Pro Gly Ser Arg Ile 
1               5                   10                  15      

Gln Ala Thr Gly Tyr Leu Glu Gly Gln Pro Ile His Ala Thr Leu Val 
            20                  25                  30          

Val Glu Glu Gly Asn Pro Ala Ala Pro Val Val Pro Thr Val Thr Val 
        35                  40                  45              

Gly Gly Glu Ala Val Thr Gly Leu Thr Ser Arg Gln Pro Met Gln Tyr 
    50                  55                  60                  

Arg Thr Leu Ser Tyr Gly Ala Gln Leu Pro Glu Val Thr Ala Ser Ala 
65                  70                  75                  80  

Glu Asn Ala Asp Val Thr Val Leu Gln Ala Ser Ala Ala Asn Gly Met 
                85                  90                  95      

Arg Ala Ser Ile Phe Ile Gln Pro Lys Asp Gly Gly Pro Leu Gln Thr 
            100                 105                 110         

Tyr Ala Ile Gln Phe Leu Glu Glu Ala Pro Lys Ile Ala His Leu Ser 
        115                 120                 125             

Leu Gln Val Glu Lys Ala Asp Ser Leu Lys Glu Asp Gln Thr Val Lys 
    130                 135                 140                 

Leu Ser Val Arg Ala His Tyr Gln Asp Gly Thr Gln Ala Val Leu Pro 
145                 150                 155                 160 

Ala Asp Lys Val Thr Phe Ser Thr Ser Gly Glu Gly Glu Val Ala Ile 
                165                 170                 175     

Arg Lys Gly Met Leu Glu Leu His Lys Pro Gly Ala Val Thr Leu Asn 
            180                 185                 190         

Ala Glu Tyr Glu Gly Ala Lys Gly Gln Val Glu Leu Thr Ile Gln Ala 
        195                 200                 205             

Asn Thr Glu Lys Lys Ile Ala Gln Ser Ile Arg Pro Val Asn Val Val 
    210                 215                 220                 

Thr Asp Leu His Gln Glu Pro Ser Leu Pro Ala Thr Val Thr Val Glu 
225                 230                 235                 240 

Tyr Asp Lys Gly Phe Pro Lys Thr His Lys Val Thr Trp Gln Ala Ile 
                245                 250                 255     

Pro Lys Glu Lys Leu Asp Ser Tyr Gln Ile Phe Glu Val Leu Gly Lys 
            260                 265                 270         

Val Glu Gly Ile Asp Leu Glu Ala Arg Ala Lys Val Ser Val Glu Gly 
        275                 280                 285             

Ile Val Ser Val Glu Glu Val Ser Val Thr Thr Pro Ile Ala Glu Ala 
    290                 295                 300                 

Pro Gln Leu Pro Glu Ser Val Arg Thr Tyr Asp Ser Asn Gly His Val 
305                 310                 315                 320 

Ser Ser Ala Lys Val Ala Trp Asp Ala Ile Arg Pro Glu Gln Tyr Ala 
                325                 330                 335     

Lys Glu Gly Val Phe Thr Val Asn Gly Arg Leu Glu Gly Thr Gln Leu 
            340                 345                 350         

Thr Thr Lys Leu His Val Arg Val Ser Ala Gln Thr Glu Gln Gly Ala 
        355                 360                 365             

Asn Ile Ser Asp Gln Trp Thr Gly Ser Glu Leu Pro Leu Ala Phe Ala 
    370                 375                 380                 

Ser Asp Ser Asn Pro Ser Asp Pro Val Ser Asn Val Asn Asp Lys Leu 
385                 390                 395                 400 

Ile Ser Tyr Asn Asn Gln Pro Ala Asn Arg Trp Thr Asn Trp Asn Arg 
                405                 410                 415     

Ser Asn Pro Glu Ala Ser Val Gly Val Leu Phe Gly Asp Ser Gly Ile 
            420                 425                 430         

Leu Ser Lys Arg Ser Val Asp Asn Leu Ser Val Gly Phe His Glu Asp 
        435                 440                 445             

His Gly Val Gly Ala Pro Lys Ser Tyr Val Ile Glu Tyr Tyr Val Gly 
    450                 455                 460                 

Lys Thr Val Pro Thr Ala Pro Lys Asn Pro Ser Phe Val Gly Asn Glu 
465                 470                 475                 480 

Asp His Val Phe Asn Asp Ser Ala Asn Trp Lys Pro Val Thr Asn Leu 
                485                 490                 495     

Lys Ala Pro Ala Gln Leu Lys Ala Gly Glu Met Asn His Phe Ser Phe 
            500                 505                 510         

Asp Lys Val Glu Thr Tyr Ala Ile Arg Ile Arg Met Val Lys Ala Asp 
        515                 520                 525             

Asn Lys Arg Gly Thr Ser Ile Thr Glu Val Gln Ile Phe Ala Lys Gln 
    530                 535                 540                 

Val Ala Ala Ala Lys Gln Gly Gln Thr Arg Ile Gln Val Asp Gly Lys 
545                 550                 555                 560 

Asp Leu Ala Asn Phe Asn Pro Asp Leu Thr Asp Tyr Tyr Leu Glu Ser 
                565                 570                 575     

Val Asp Gly Lys Val Pro Ala Val Thr Ala Asn Val Ser Asn Asn Gly 
            580                 585                 590         

Leu Ala Thr Val Val Pro Ser Val Arg Glu Gly Glu Pro Val Arg Val 
        595                 600                 605             

Ile Ala Lys Ala Glu Asn Gly Asp Ile Leu Gly Glu Tyr Arg Leu His 
    610                 615                 620                 

Phe Thr Lys Asp Lys Asn Leu Leu Ser His Lys Pro Val Ala Ala Val 
625                 630                 635                 640 

Lys Gln Ala Arg Leu Leu Gln Val Gly Gln Ala Leu Glu Leu Pro Thr 
                645                 650                 655     

Lys Val Pro Val Tyr Phe Thr Gly Lys Asp Gly Tyr Glu Thr Lys Asp 
            660                 665                 670         

Leu Thr Val Glu Trp Glu Glu Val Pro Ala Glu Asn Leu Thr Lys Ala 
        675                 680                 685             

Gly Gln Phe Thr Val Arg Gly Arg Val Leu Gly Ser Asn Leu Val Ala 
    690                 695                 700                 

Glu Val Thr Val Arg Val Thr Asp Lys Leu Gly Glu Thr Leu Ser Asp 
705                 710                 715                 720 

Asn Pro Asn Tyr Asp Glu Asn Ser Asn Gln Ala Phe Ala Ser Ala Thr 
                725                 730                 735     

Asn Asp Ile Asp Lys Asn Ser His Asp Arg Val Asp Tyr Leu Asn Asp 
            740                 745                 750         

Gly Asp His Ser Glu Asn Arg Arg Trp Thr Asn Trp Ser Pro Thr Pro 
        755                 760                 765             

Ser Ser Asn Pro Glu Val Ser Ala Gly Val Ile Phe Arg Glu Asn Gly 
    770                 775                 780                 

Lys Ile Val Glu Arg Thr Val Ala Gln Ala Lys Leu His Phe Phe Ala 
785                 790                 795                 800 

Asp Ser Gly Thr Asp Ala Pro Ser Lys Leu Val Leu Glu Arg Tyr Val 
                805                 810                 815     

Gly Pro Gly Phe Glu Val Pro Thr Tyr Tyr Ser Asn Tyr Gln Ala Tyr 
            820                 825                 830         

Glu Ser Gly His Pro Phe Asn Asn Pro Glu Asn Trp Glu Ala Val Pro 
        835                 840                 845             

Tyr Arg Ala Asp Lys Asp Ile Ala Ala Gly Asp Glu Ile Asn Val Thr 
    850                 855                 860                 

Phe Lys Ala Val Lys Ala Lys Val Met Arg Trp Arg Met Glu Arg Lys 
865                 870                 875                 880 

Ala Asp Lys Ser Gly Val Ala Met Ile Glu Met Thr Phe Leu Ala Pro 
                885                 890                 895     

Ser Glu Leu Pro Gln Glu Ser Thr Gln Ser Lys Ile Leu Val Asp Gly 
            900                 905                 910         

Lys Glu Leu Ala Asp Phe Ala Glu Asn Arg Gln Asp Tyr Gln Ile Thr 
        915                 920                 925             

Tyr Lys Gly Gln Arg Pro Lys Val Ser Val Glu Glu Asn Asn Gln Val 
    930                 935                 940                 

Ala Ser Thr Val Val Asp Ser Gly Glu Asp Ser Leu Pro Val Leu Val 
945                 950                 955                 960 

Arg Leu Val Ser Glu Ser Gly Lys Gln Val Lys Glu Tyr Arg Ile Gln 
                965                 970                 975     

Leu Thr Lys Glu Lys Pro Val Ser Ala Val Gln Glu Asp Leu Pro Lys 
            980                 985                 990         

Leu Glu Phe Val Glu Lys Asp Leu Ala Tyr Lys Thr Val Glu Lys Lys 
        995                 1000                1005            

Asp Ser Thr Leu Tyr Leu Gly Glu Thr Arg Val Glu Gln Glu Gly Lys 
    1010                1015                1020                

Val Gly Lys Glu Arg Ile Phe Thr Val Ile Asn Pro Asp Gly Ser Lys 
1025                1030                1035                1040

Glu Glu Lys Leu Arg Glu Val Val Glu Val Pro Thr Asp Arg Ile Val 
                1045                1050                1055    

Leu Val Gly Thr Lys Pro Val Ala Gln Glu Ala Lys Lys Pro Gln Val 
            1060                1065                1070        

Ser Glu Lys Ala Asp Thr Lys Pro Ile Asp Ser Ser Glu Ala Asp Gln 
        1075                1080                1085            

Thr Asn Lys Ala Gln 
    1090            

<210>   179
<211>   883
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   179
Met Lys Lys Val Arg Lys Ile Phe Gln Lys Ala Val Ala Gly Leu Cys 
1               5                   10                  15      

Cys Ile Ser Gln Leu Thr Ala Phe Ser Ser Ile Val Ala Leu Ala Glu 
            20                  25                  30          

Thr Pro Glu Thr Ser Pro Ala Ile Gly Lys Val Val Ile Lys Glu Thr 
        35                  40                  45              

Gly Glu Gly Gly Ala Leu Leu Gly Asp Ala Val Phe Glu Leu Lys Asn 
    50                  55                  60                  

Asn Thr Asp Gly Thr Thr Val Ser Gln Arg Thr Glu Ala Gln Thr Gly 
65                  70                  75                  80  

Glu Ala Ile Phe Ser Asn Ile Lys Pro Gly Thr Tyr Thr Leu Thr Glu 
                85                  90                  95      

Ala Gln Pro Pro Val Gly Tyr Lys Pro Ser Thr Lys Gln Trp Thr Val 
            100                 105                 110         

Glu Val Glu Lys Asn Gly Arg Thr Thr Val Gln Gly Glu Gln Val Glu 
        115                 120                 125             

Asn Arg Glu Glu Ala Leu Ser Asp Gln Tyr Pro Gln Thr Gly Thr Tyr 
    130                 135                 140                 

Pro Asp Val Gln Thr Pro Tyr Gln Ile Ile Lys Val Asp Gly Ser Glu 
145                 150                 155                 160 

Lys Asn Gly Gln His Lys Ala Leu Asn Pro Asn Pro Tyr Glu Arg Val 
                165                 170                 175     

Ile Pro Glu Gly Thr Leu Ser Lys Arg Ile Tyr Gln Val Asn Asn Leu 
            180                 185                 190         

Asp Asp Asn Gln Tyr Gly Ile Glu Leu Thr Val Ser Gly Lys Thr Thr 
        195                 200                 205             

Val Glu Thr Lys Glu Ala Ser Thr Pro Leu Asp Val Val Ile Leu Leu 
    210                 215                 220                 

Asp Asn Ser Asn Ser Met Ser Asn Ile Arg His Asn His Ala His Arg 
225                 230                 235                 240 

Ala Glu Lys Ala Gly Glu Ala Thr Arg Ala Leu Val Asp Lys Ile Thr 
                245                 250                 255     

Ser Asn Pro Asp Asn Arg Val Ala Leu Val Thr Tyr Gly Ser Thr Ile 
            260                 265                 270         

Phe Asp Gly Ser Glu Ala Thr Val Glu Lys Gly Val Ala Asp Ala Asn 
        275                 280                 285             

Gly Lys Ile Leu Asn Asp Ser Ala Leu Trp Thr Phe Asp Arg Thr Thr 
    290                 295                 300                 

Phe Thr Ala Lys Thr Tyr Asn Tyr Ser Phe Leu Asn Leu Thr Ser Asp 
305                 310                 315                 320 

Pro Thr Asp Ile Gln Thr Ile Lys Asp Arg Ile Pro Ser Asp Ala Glu 
                325                 330                 335     

Glu Leu Asn Lys Asp Lys Leu Met Tyr Gln Phe Gly Ala Thr Phe Thr 
            340                 345                 350         

Gln Lys Ala Leu Met Thr Ala Asp Asp Ile Leu Thr Lys Gln Ala Arg 
        355                 360                 365             

Pro Asn Ser Lys Lys Val Ile Phe His Ile Thr Asp Gly Val Pro Thr 
    370                 375                 380                 

Met Ser Tyr Pro Ile Asn Phe Lys Tyr Thr Gly Thr Thr Gln Ser Tyr 
385                 390                 395                 400 

Arg Thr Gln Leu Asn Asn Phe Lys Ala Lys Thr Pro Asn Ser Ser Gly 
                405                 410                 415     

Ile Leu Leu Glu Asp Phe Val Thr Trp Ser Ala Asp Gly Glu His Lys 
            420                 425                 430         

Ile Val Arg Gly Asp Gly Glu Ser Tyr Gln Met Phe Thr Lys Lys Pro 
        435                 440                 445             

Val Thr Asp Gln Tyr Gly Val His Gln Ile Leu Ser Ile Thr Ser Met 
    450                 455                 460                 

Glu Gln Arg Ala Lys Leu Val Ser Ala Gly Tyr Arg Phe Tyr Gly Thr 
465                 470                 475                 480 

Asp Leu Tyr Leu Tyr Trp Arg Asp Ser Ile Leu Ala Tyr Pro Phe Asn 
                485                 490                 495     

Ser Ser Thr Asp Trp Ile Thr Asn His Gly Asp Pro Thr Thr Trp Tyr 
            500                 505                 510         

Tyr Asn Gly Asn Met Ala Gln Asp Gly Tyr Asp Val Phe Thr Val Gly 
        515                 520                 525             

Val Gly Val Asn Gly Asp Pro Gly Thr Asp Glu Ala Thr Ala Thr Arg 
    530                 535                 540                 

Phe Met Gln Ser Ile Ser Ser Ser Pro Asp Asn Tyr Thr Asn Val Ala 
545                 550                 555                 560 

Asp Pro Ser Gln Ile Leu Gln Glu Leu Asn Arg Tyr Phe Tyr Thr Ile 
                565                 570                 575     

Val Asn Glu Lys Lys Ser Ile Glu Asn Gly Thr Ile Thr Asp Pro Met 
            580                 585                 590         

Gly Glu Leu Ile Asp Phe Gln Leu Gly Ala Asp Gly Arg Phe Asp Pro 
        595                 600                 605             

Ala Asp Tyr Thr Leu Thr Ala Asn Asp Gly Ser Ser Leu Val Asn Asn 
    610                 615                 620                 

Val Pro Thr Gly Gly Pro Gln Asn Asp Gly Gly Leu Leu Lys Asn Ala 
625                 630                 635                 640 

Lys Val Phe Tyr Asp Thr Thr Glu Lys Arg Ile Arg Val Thr Gly Leu 
                645                 650                 655     

Tyr Leu Gly Thr Gly Glu Lys Val Thr Leu Thr Tyr Asn Val Arg Leu 
            660                 665                 670         

Asn Asp Gln Phe Val Ser Asn Lys Phe Tyr Asp Thr Asn Gly Arg Thr 
        675                 680                 685             

Thr Leu His Pro Lys Glu Val Glu Lys Asn Thr Val Arg Asp Phe Pro 
    690                 695                 700                 

Ile Pro Lys Ile Arg Asp Val Arg Lys Tyr Pro Glu Ile Thr Ile Pro 
705                 710                 715                 720 

Lys Glu Lys Lys Leu Gly Glu Ile Glu Phe Ile Lys Ile Asn Lys Asn 
                725                 730                 735     

Asp Lys Lys Pro Leu Arg Asp Ala Val Phe Ser Leu Gln Lys Gln His 
            740                 745                 750         

Pro Asp Tyr Pro Asp Ile Tyr Gly Ala Ile Asp Gln Asn Gly Thr Tyr 
        755                 760                 765             

Gln Asn Val Arg Thr Gly Glu Asp Gly Lys Leu Thr Phe Lys Asn Leu 
    770                 775                 780                 

Ser Asp Gly Lys Tyr Arg Leu Phe Glu Asn Ser Glu Pro Ala Gly Tyr 
785                 790                 795                 800 

Lys Pro Val Gln Asn Lys Pro Ile Val Ala Phe Gln Ile Val Asn Gly 
                805                 810                 815     

Glu Val Arg Asp Val Thr Ser Ile Val Pro Gln Asp Ile Pro Ala Gly 
            820                 825                 830         

Tyr Glu Phe Thr Asn Asp Lys His Tyr Ile Thr Asn Glu Pro Ile Pro 
        835                 840                 845             

Pro Lys Arg Glu Tyr Pro Arg Thr Gly Gly Ile Gly Met Leu Pro Phe 
    850                 855                 860                 

Tyr Leu Ile Gly Cys Met Met Met Gly Gly Val Leu Leu Tyr Thr Arg 
865                 870                 875                 880 

Lys His Pro 
            

<210>   180
<211>   1247
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   180
Ala Asp Gly Val Thr Pro Thr Thr Thr Glu Asn Gln Pro Thr Ile His 
1               5                   10                  15      

Thr Val Ser Asp Ser Pro Gln Ser Ser Glu Asn Arg Thr Glu Glu Thr 
            20                  25                  30          

Pro Lys Ala Glu Leu Gln Pro Glu Ala Pro Lys Thr Val Glu Thr Glu 
        35                  40                  45              

Thr Pro Ala Thr Asp Lys Val Ala Ser Leu Pro Lys Thr Glu Glu Lys 
    50                  55                  60                  

Pro Gln Glu Glu Val Ser Ser Thr Pro Ser Asp Lys Ala Glu Val Val 
65                  70                  75                  80  

Thr Pro Thr Ser Ala Glu Lys Glu Thr Ala Asn Lys Lys Glu Glu Glu 
                85                  90                  95      

Ala Ser Pro Lys Lys Glu Glu Ala Lys Glu Val Asp Ser Lys Glu Ser 
            100                 105                 110         

Asn Thr Asp Lys Thr Asp Lys Asp Lys Pro Ala Lys Lys Asp Glu Ala 
        115                 120                 125             

Lys Ala Glu Ala Asp Lys Pro Glu Thr Glu Thr Gly Lys Glu Arg Ala 
    130                 135                 140                 

Ala Thr Val Asn Glu Lys Leu Ala Lys Lys Lys Ile Val Ser Ile Asp 
145                 150                 155                 160 

Ala Gly Arg Lys Tyr Phe Ser Pro Glu Gln Leu Lys Glu Ile Ile Asp 
                165                 170                 175     

Lys Ala Lys His Tyr Gly Tyr Thr Asp Leu His Leu Leu Val Gly Asn 
            180                 185                 190         

Asp Gly Leu Arg Phe Met Leu Asp Asp Met Ser Ile Thr Ala Asn Gly 
        195                 200                 205             

Lys Thr Tyr Ala Ser Asp Asp Val Lys Arg Ala Ile Glu Lys Gly Thr 
    210                 215                 220                 

Asn Asp Tyr Tyr Asn Asp Pro Asn Gly Asn His Leu Thr Glu Ser Gln 
225                 230                 235                 240 

Met Thr Asp Leu Ile Asn Tyr Ala Lys Asp Lys Gly Ile Gly Leu Ile 
                245                 250                 255     

Pro Thr Val Asn Ser Pro Gly His Met Asp Ala Ile Leu Asn Ala Met 
            260                 265                 270         

Lys Glu Leu Gly Ile Gln Asn Pro Asn Phe Ser Tyr Phe Gly Lys Lys 
        275                 280                 285             

Ser Ala Arg Thr Val Asp Leu Asp Asn Glu Gln Ala Val Ala Phe Thr 
    290                 295                 300                 

Lys Ala Leu Ile Asp Lys Tyr Ala Ala Tyr Phe Ala Lys Lys Thr Glu 
305                 310                 315                 320 

Ile Phe Asn Ile Gly Leu Asp Glu Tyr Ala Asn Asp Ala Thr Asp Ala 
                325                 330                 335     

Lys Gly Trp Ser Val Leu Gln Ala Asp Lys Tyr Tyr Pro Asn Glu Gly 
            340                 345                 350         

Tyr Pro Val Lys Gly Tyr Glu Lys Phe Ile Ala Tyr Ala Asn Asp Leu 
        355                 360                 365             

Ala Arg Ile Val Lys Ser His Gly Leu Lys Pro Met Ala Phe Asn Asp 
    370                 375                 380                 

Gly Ile Tyr Tyr Asn Ser Asp Thr Ser Phe Gly Ser Phe Asp Lys Asp 
385                 390                 395                 400 

Ile Ile Val Ser Met Trp Thr Gly Gly Trp Gly Gly Tyr Asp Val Ala 
                405                 410                 415     

Ser Ser Lys Leu Leu Ala Glu Lys Gly His Gln Ile Leu Asn Thr Asn 
            420                 425                 430         

Asp Ala Trp Cys Tyr Val Leu Gly Arg Asn Ala Asp Gly Gln Gly Trp 
        435                 440                 445             

Tyr Asn Leu Asp Gln Gly Leu Asn Gly Ile Lys Asn Thr Pro Ile Thr 
    450                 455                 460                 

Ser Val Pro Lys Thr Glu Gly Ala Asp Ile Pro Ile Ile Gly Gly Met 
465                 470                 475                 480 

Val Ala Ala Trp Ala Asp Thr Pro Ser Ala Arg Tyr Ser Pro Ser His 
                485                 490                 495     

Leu Phe Lys Leu Met Arg His Phe Ala Asn Ala Asn Ala Glu Tyr Phe 
            500                 505                 510         

Ala Ala Asp Tyr Glu Ser Ala Glu Gln Ala Leu Asn Glu Val Pro Lys 
        515                 520                 525             

Asp Leu Asn Arg Tyr Thr Ala Glu Ser Val Ala Ala Val Lys Glu Ala 
    530                 535                 540                 

Glu Lys Ala Ile Arg Ser Leu Asp Ser Asn Leu Ser Arg Ala Gln Gln 
545                 550                 555                 560 

Asp Thr Ile Asp Gln Ala Ile Ala Lys Leu Gln Glu Thr Val Asn Asn 
                565                 570                 575     

Leu Thr Leu Thr Pro Glu Ala Gln Lys Glu Glu Glu Ala Lys Arg Glu 
            580                 585                 590         

Val Glu Lys Leu Ala Lys Asn Lys Val Ile Ser Ile Asp Ala Gly Arg 
        595                 600                 605             

Lys Tyr Phe Thr Leu Asp Gln Leu Lys Arg Ile Val Asp Lys Ala Ser 
    610                 615                 620                 

Glu Leu Gly Tyr Ser Asp Val His Leu Leu Leu Gly Asn Asp Gly Leu 
625                 630                 635                 640 

Arg Phe Leu Leu Asn Asp Met Thr Ile Thr Ala Asn Gly Lys Thr Tyr 
                645                 650                 655     

Ala Ser Asp Asp Val Lys Lys Ala Ile Ile Glu Gly Thr Lys Ala Tyr 
            660                 665                 670         

Tyr Asp Asp Pro Asn Gly Thr Ala Leu Thr Gln Ala Glu Val Thr Glu 
        675                 680                 685             

Leu Ile Glu Tyr Ala Lys Ser Lys Asp Ile Gly Leu Ile Pro Ala Ile 
    690                 695                 700                 

Asn Ser Pro Gly His Met Asp Ala Met Leu Val Ala Met Glu Lys Leu 
705                 710                 715                 720 

Gly Ile Lys Asn Pro Gln Ala His Phe Asp Lys Val Ser Lys Thr Thr 
                725                 730                 735     

Met Asp Leu Lys Asn Glu Glu Ala Met Asn Phe Val Lys Ala Leu Ile 
            740                 745                 750         

Gly Lys Tyr Met Asp Phe Phe Ala Gly Lys Thr Lys Ile Phe Asn Phe 
        755                 760                 765             

Gly Thr Asp Glu Tyr Ala Asn Asp Ala Thr Ser Ala Gln Gly Trp Tyr 
    770                 775                 780                 

Tyr Leu Lys Trp Tyr Gln Leu Tyr Gly Lys Phe Ala Glu Tyr Ala Asn 
785                 790                 795                 800 

Thr Leu Ala Ala Met Ala Lys Glu Arg Gly Leu Gln Pro Met Ala Phe 
                805                 810                 815     

Asn Asp Gly Phe Tyr Tyr Glu Asp Lys Asp Asp Val Gln Phe Asp Lys 
            820                 825                 830         

Asp Val Leu Ile Ser Tyr Trp Ser Lys Gly Trp Trp Gly Tyr Asn Leu 
        835                 840                 845             

Ala Ser Pro Gln Tyr Leu Ala Ser Lys Gly Tyr Lys Phe Leu Asn Thr 
    850                 855                 860                 

Asn Gly Asp Trp Tyr Tyr Val Ile Gly Asn His Lys Gln Asp Glu Ala 
865                 870                 875                 880 

Tyr Pro Leu Ser Lys Ala Val Glu Asn Ser Gly Lys Val Pro Phe Asn 
                885                 890                 895     

Gln Leu Ala Ser Thr Lys Tyr Pro Glu Val Asp Leu Pro Thr Val Gly 
            900                 905                 910         

Ser Met Leu Ser Ile Trp Ala Asp Arg Pro Ser Ala Glu Tyr Lys Glu 
        915                 920                 925             

Glu Glu Ile Phe Glu Leu Met Thr Ala Phe Ala Asp His Asn Lys Asp 
    930                 935                 940                 

Tyr Phe Arg Ala Asn Tyr Asn Ala Leu Arg Glu Glu Leu Ala Lys Ile 
945                 950                 955                 960 

Pro Thr Asn Leu Glu Gly Tyr Ser Lys Glu Ser Leu Glu Ala Leu Asp 
                965                 970                 975     

Ala Ala Lys Thr Ala Leu Asn Tyr Asn Leu Asn Arg Asn Lys Gln Ala 
            980                 985                 990         

Glu Leu Asp Thr Leu Val Ala Asn Leu Lys Ala Ala Leu Gln Gly Leu 
        995                 1000                1005            

Lys Pro Ala Ala Thr His Ser Gly Ser Leu Asp Glu Asn Glu Val Ala 
    1010                1015                1020                

Ala Asn Val Glu Thr Arg Pro Glu Leu Ile Thr Arg Thr Glu Glu Ile 
1025                1030                1035                1040

Pro Phe Glu Val Ile Lys Lys Glu Asn Pro Asn Leu Pro Ala Gly Gln 
                1045                1050                1055    

Glu Asn Ile Ile Thr Ala Gly Val Lys Gly Glu Arg Thr His Tyr Ile 
            1060                1065                1070        

Ser Val Leu Thr Glu Asn Gly Lys Thr Thr Glu Thr Val Leu Asp Ser 
        1075                1080                1085            

Gln Val Thr Lys Glu Val Ile Asn Gln Val Val Glu Val Gly Ser Pro 
    1090                1095                1100                

Val Thr His Lys Gly Asp Glu Ser Gly Leu Ala Pro Thr Thr Glu Val 
1105                1110                1115                1120

Lys Pro Arg Leu Asp Ile Gln Glu Glu Glu Ile Pro Phe Thr Thr Val 
                1125                1130                1135    

Thr Arg Glu Asn Pro Leu Leu Leu Lys Gly Lys Thr Gln Val Ile Thr 
            1140                1145                1150        

Lys Gly Val Asn Gly His Arg Ser Asn Phe Tyr Ser Val Ser Thr Ser 
        1155                1160                1165            

Ala Asp Gly Lys Glu Val Lys Thr Leu Val Asn Ser Val Val Ala Gln 
    1170                1175                1180                

Glu Ala Val Thr Gln Ile Val Glu Val Gly Thr Met Val Thr His Val 
1185                1190                1195                1200

Gly Asp Glu Asn Gly Gln Ala Ala Ile Ala Glu Glu Lys Pro Lys Leu 
                1205                1210                1215    

Glu Ile Pro Ser Gln Pro Ala Pro Ser Thr Ala Pro Ala Glu Glu Ser 
            1220                1225                1230        

Lys Ala Leu Pro Gln Asp Pro Ala Pro Val Val Thr Glu Lys Lys 
        1235                1240                1245        

<210>   181
<211>   1008
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   181
Gly Ala Glu Glu Thr Thr Thr Asn Thr Ile Gln Gln Ser Gln Lys Glu 
1               5                   10                  15      

Val Gln Tyr Gln Gln Arg Asp Thr Lys Asn Leu Val Glu Asn Gly Asp 
            20                  25                  30          

Phe Gly Gln Thr Glu Asp Gly Ser Ser Pro Trp Thr Gly Ser Lys Ala 
        35                  40                  45              

Gln Gly Trp Ser Ala Trp Val Asp Gln Lys Asn Ser Ser Ala Asp Ala 
    50                  55                  60                  

Ser Thr Arg Val Ile Glu Ala Lys Asp Gly Ala Ile Thr Ile Ser Ser 
65                  70                  75                  80  

Pro Glu Lys Leu Arg Ala Ala Val His Arg Met Val Pro Ile Glu Ala 
                85                  90                  95      

Lys Lys Lys Tyr Lys Leu Arg Phe Lys Ile Lys Thr Asp Asn Lys Val 
            100                 105                 110         

Gly Ile Ala Lys Val Arg Ile Ile Glu Glu Ser Gly Lys Asp Lys Arg 
        115                 120                 125             

Leu Trp Asn Ser Ala Thr Thr Ser Gly Thr Lys Asp Trp Gln Thr Ile 
    130                 135                 140                 

Glu Ala Asp Tyr Ser Pro Thr Leu Asp Val Asp Lys Ile Lys Leu Glu 
145                 150                 155                 160 

Leu Phe Tyr Glu Thr Gly Thr Gly Thr Val Ser Phe Lys Asp Ile Glu 
                165                 170                 175     

Leu Val Glu Val Ala Asp Gln Pro Ser Glu Asp Ser Gln Thr Asp Lys 
            180                 185                 190         

Gln Leu Glu Glu Lys Ile Asp Leu Pro Ile Gly Lys Lys His Val Phe 
        195                 200                 205             

Ser Leu Ala Asp Tyr Thr Tyr Lys Val Glu Asn Pro Asp Val Ala Ser 
    210                 215                 220                 

Val Lys Asn Gly Ile Leu Glu Pro Leu Lys Glu Gly Thr Thr Asn Val 
225                 230                 235                 240 

Ile Val Ser Lys Asp Gly Lys Glu Val Lys Lys Ile Pro Leu Lys Ile 
                245                 250                 255     

Leu Ala Ser Val Lys Asp Thr Tyr Thr Asp Arg Leu Asp Asp Trp Asn 
            260                 265                 270         

Gly Ile Ile Ala Gly Asn Gln Tyr Tyr Asp Ser Lys Asn Glu Gln Met 
        275                 280                 285             

Ala Lys Leu Asn Gln Glu Leu Glu Gly Lys Val Ala Asp Ser Leu Ser 
    290                 295                 300                 

Ser Ile Ser Ser Gln Ala Asp Arg Ile Tyr Leu Trp Glu Lys Phe Ser 
305                 310                 315                 320 

Asn Tyr Lys Thr Ser Ala Asn Leu Thr Ala Thr Tyr Arg Lys Leu Glu 
                325                 330                 335     

Glu Met Ala Lys Gln Val Thr Asn Pro Ser Ser Arg Tyr Tyr Gln Asp 
            340                 345                 350         

Glu Thr Val Val Arg Thr Val Arg Asp Ser Met Glu Trp Met His Lys 
        355                 360                 365             

His Val Tyr Asn Ser Glu Lys Ser Ile Val Gly Asn Trp Trp Asp Tyr 
    370                 375                 380                 

Glu Ile Gly Thr Pro Arg Ala Ile Asn Asn Thr Leu Ser Leu Met Lys 
385                 390                 395                 400 

Glu Tyr Phe Ser Asp Glu Glu Ile Lys Lys Tyr Thr Asp Val Ile Glu 
                405                 410                 415     

Lys Phe Val Pro Asp Pro Glu His Phe Arg Lys Thr Thr Asp Asn Pro 
            420                 425                 430         

Phe Lys Ala Leu Gly Gly Asn Leu Val Asp Met Gly Arg Val Lys Val 
        435                 440                 445             

Ile Ala Gly Leu Leu Arg Lys Asp Asp Gln Glu Ile Ser Ser Thr Ile 
    450                 455                 460                 

Arg Ser Ile Glu Gln Val Phe Lys Leu Val Asp Gln Gly Glu Gly Phe 
465                 470                 475                 480 

Tyr Gln Asp Gly Ser Tyr Ile Asp His Thr Asn Val Ala Tyr Thr Gly 
                485                 490                 495     

Ala Tyr Gly Asn Val Leu Ile Asp Gly Leu Ser Gln Leu Leu Pro Val 
            500                 505                 510         

Ile Gln Lys Thr Lys Asn Pro Ile Asp Lys Asp Lys Met Gln Thr Met 
        515                 520                 525             

Tyr His Trp Ile Asp Lys Ser Phe Ala Pro Leu Leu Val Asn Gly Glu 
    530                 535                 540                 

Leu Met Asp Met Ser Arg Gly Arg Ser Ile Ser Arg Ala Asn Ser Glu 
545                 550                 555                 560 

Gly His Val Ala Ala Val Glu Val Leu Arg Gly Ile His Arg Ile Ala 
                565                 570                 575     

Asp Met Ser Glu Gly Glu Thr Lys Gln Arg Leu Gln Ser Leu Val Lys 
            580                 585                 590         

Thr Ile Val Gln Ser Asp Ser Tyr Tyr Asp Val Phe Lys Asn Leu Lys 
        595                 600                 605             

Thr Tyr Lys Asp Ile Ser Leu Met Gln Ser Leu Leu Ser Asp Ala Gly 
    610                 615                 620                 

Val Ala Ser Val Pro Arg Thr Ser Tyr Leu Ser Ala Phe Asn Lys Met 
625                 630                 635                 640 

Asp Lys Thr Ala Met Tyr Asn Ala Glu Lys Gly Phe Gly Phe Gly Leu 
                645                 650                 655     

Ser Leu Phe Ser Ser Arg Thr Leu Asn Tyr Glu His Met Asn Lys Glu 
            660                 665                 670         

Asn Lys Arg Gly Trp Tyr Thr Ser Asp Gly Met Phe Tyr Leu Tyr Asn 
        675                 680                 685             

Gly Asp Leu Ser His Tyr Ser Asp Gly Tyr Trp Pro Thr Val Asn Pro 
    690                 695                 700                 

Tyr Lys Met Pro Gly Thr Thr Glu Thr Asp Ala Lys Arg Ala Asp Ser 
705                 710                 715                 720 

Asp Thr Gly Lys Val Leu Pro Ser Ala Phe Val Gly Thr Ser Lys Leu 
                725                 730                 735     

Asp Asp Ala Asn Ala Thr Ala Thr Met Asp Phe Thr Asn Trp Asn Gln 
            740                 745                 750         

Thr Leu Thr Ala His Lys Ser Trp Phe Met Leu Lys Asp Lys Ile Ala 
        755                 760                 765             

Phe Leu Gly Ser Asn Ile Gln Asn Thr Ser Thr Asp Thr Ala Ala Thr 
    770                 775                 780                 

Thr Ile Asp Gln Arg Lys Leu Glu Ser Ser Asn Pro Tyr Lys Val Tyr 
785                 790                 795                 800 

Val Asn Asp Lys Glu Ala Ser Leu Thr Glu Gln Glu Lys Asp Tyr Pro 
                805                 810                 815     

Glu Thr Gln Ser Val Phe Leu Glu Ser Ser Asp Ser Lys Lys Asn Ile 
            820                 825                 830         

Gly Tyr Phe Phe Phe Lys Lys Ser Ser Ile Ser Met Ser Lys Ala Leu 
        835                 840                 845             

Gln Lys Gly Ala Trp Lys Asp Ile Asn Glu Gly Gln Ser Asp Lys Glu 
    850                 855                 860                 

Val Glu Asn Glu Phe Leu Thr Ile Ser Gln Ala His Lys Gln Asn Gly 
865                 870                 875                 880 

Asp Ser Tyr Gly Tyr Met Leu Ile Pro Asn Val Asp Arg Ala Thr Phe 
                885                 890                 895     

Asn Gln Met Ile Lys Glu Leu Glu Ser Ser Leu Ile Glu Asn Asn Glu 
            900                 905                 910         

Thr Leu Gln Ser Val Tyr Asp Ala Lys Gln Gly Val Trp Gly Ile Val 
        915                 920                 925             

Lys Tyr Asp Asp Ser Val Ser Thr Ile Ser Asn Gln Phe Gln Val Leu 
    930                 935                 940                 

Lys Arg Gly Val Tyr Thr Ile Arg Lys Glu Gly Asp Glu Tyr Lys Ile 
945                 950                 955                 960 

Ala Tyr Tyr Asn Pro Glu Thr Gln Glu Ser Ala Pro Asp Gln Glu Val 
                965                 970                 975     

Phe Lys Lys Leu Glu Gln Ala Ala Gln Pro Gln Val Gln Asn Ser Lys 
            980                 985                 990         

Glu Lys Glu Lys Ser Glu Glu Glu Lys Asn His Ser Asp Gln Lys Asn 
        995                 1000                1005            


<210>   182
<211>   628
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   182
Gly Ala Glu Glu Thr Thr Thr Asn Thr Ile Gln Gln Ser Gln Lys Glu 
1               5                   10                  15      

Val Gln Tyr Gln Gln Arg Asp Thr Lys Asn Leu Val Glu Asn Gly Asp 
            20                  25                  30          

Phe Gly Gln Thr Glu Asp Gly Ser Ser Pro Trp Thr Gly Ser Lys Ala 
        35                  40                  45              

Gln Gly Trp Ser Ala Trp Val Asp Gln Lys Asn Ser Ser Ala Asp Ala 
    50                  55                  60                  

Ser Thr Arg Val Ile Glu Ala Lys Asp Gly Ala Ile Thr Ile Ser Ser 
65                  70                  75                  80  

Pro Glu Lys Leu Arg Ala Ala Val His Arg Met Val Pro Ile Glu Ala 
                85                  90                  95      

Lys Lys Lys Tyr Lys Leu Arg Phe Lys Ile Lys Thr Asp Asn Lys Val 
            100                 105                 110         

Gly Ile Ala Lys Val Arg Ile Ile Glu Glu Ser Gly Lys Asp Lys Arg 
        115                 120                 125             

Leu Trp Asn Ser Ala Thr Thr Ser Gly Thr Lys Asp Trp Gln Thr Ile 
    130                 135                 140                 

Glu Ala Asp Tyr Ser Pro Thr Leu Asp Val Asp Lys Ile Lys Leu Glu 
145                 150                 155                 160 

Leu Phe Tyr Glu Thr Gly Thr Gly Thr Val Ser Phe Lys Asp Ile Glu 
                165                 170                 175     

Leu Val Glu Val Ala Asp Gln Pro Ser Glu Asp Ser Gln Thr Asp Lys 
            180                 185                 190         

Gln Leu Glu Glu Lys Ile Asp Leu Pro Ile Gly Lys Lys His Val Phe 
        195                 200                 205             

Ser Leu Ala Asp Tyr Thr Tyr Lys Val Glu Asn Pro Asp Val Ala Ser 
    210                 215                 220                 

Val Lys Asn Gly Ile Leu Glu Pro Leu Lys Glu Gly Thr Thr Asn Val 
225                 230                 235                 240 

Ile Val Ser Lys Asp Gly Lys Glu Val Lys Lys Ile Pro Leu Lys Ile 
                245                 250                 255     

Leu Ala Ser Val Lys Asp Thr Tyr Thr Asp Arg Leu Asp Asp Trp Asn 
            260                 265                 270         

Gly Ile Ile Ala Gly Asn Gln Tyr Tyr Asp Ser Lys Asn Glu Gln Met 
        275                 280                 285             

Ala Lys Leu Asn Gln Glu Leu Glu Gly Lys Val Ala Asp Ser Leu Ser 
    290                 295                 300                 

Ser Ile Ser Ser Gln Ala Asp Arg Ile Tyr Leu Trp Glu Lys Phe Ser 
305                 310                 315                 320 

Asn Tyr Lys Thr Ser Ala Asn Leu Thr Ala Thr Tyr Arg Lys Leu Glu 
                325                 330                 335     

Glu Met Ala Lys Gln Val Thr Asn Pro Ser Ser Arg Tyr Tyr Gln Asp 
            340                 345                 350         

Glu Thr Val Val Arg Thr Val Arg Asp Ser Met Glu Trp Met His Lys 
        355                 360                 365             

His Val Tyr Asn Ser Glu Lys Ser Ile Val Gly Asn Trp Trp Asp Tyr 
    370                 375                 380                 

Glu Ile Gly Thr Pro Arg Ala Ile Asn Asn Thr Leu Ser Leu Met Lys 
385                 390                 395                 400 

Glu Tyr Phe Ser Asp Glu Glu Ile Lys Lys Tyr Thr Asp Val Ile Glu 
                405                 410                 415     

Lys Phe Val Pro Asp Pro Glu His Phe Arg Lys Thr Thr Asp Asn Pro 
            420                 425                 430         

Phe Lys Ala Leu Gly Gly Asn Leu Val Asp Met Gly Arg Val Lys Val 
        435                 440                 445             

Ile Ala Gly Leu Leu Arg Lys Asp Asp Gln Glu Ile Ser Ser Thr Ile 
    450                 455                 460                 

Arg Ser Ile Glu Gln Val Phe Lys Leu Val Asp Gln Gly Glu Gly Phe 
465                 470                 475                 480 

Tyr Gln Asp Gly Ser Tyr Ile Asp His Thr Asn Val Ala Tyr Thr Gly 
                485                 490                 495     

Ala Tyr Gly Asn Val Leu Ile Asp Gly Leu Ser Gln Leu Leu Pro Val 
            500                 505                 510         

Ile Gln Lys Thr Lys Asn Pro Ile Asp Lys Asp Lys Met Gln Thr Met 
        515                 520                 525             

Tyr His Trp Ile Asp Lys Ser Phe Ala Pro Leu Leu Val Asn Gly Glu 
    530                 535                 540                 

Leu Met Asp Met Ser Arg Gly Arg Ser Ile Ser Arg Ala Asn Ser Glu 
545                 550                 555                 560 

Gly His Val Ala Ala Val Glu Val Leu Arg Gly Ile His Arg Ile Ala 
                565                 570                 575     

Asp Met Ser Glu Gly Glu Thr Lys Gln Arg Leu Gln Ser Leu Val Lys 
            580                 585                 590         

Thr Ile Val Gln Ser Asp Ser Tyr Tyr Asp Val Phe Lys Asn Leu Lys 
        595                 600                 605             

Thr Tyr Lys Asp Ile Ser Leu Met Gln Ser Leu Leu Ser Asp Ala Gly 
    610                 615                 620                 

Val Ala Ser Val 
625             

<210>   183
<211>   452
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   183
Ala Asn Ser Glu Gly His Val Ala Ala Val Glu Val Leu Arg Gly Ile 
1               5                   10                  15      

His Arg Ile Ala Asp Met Ser Glu Gly Glu Thr Lys Gln Arg Leu Gln 
            20                  25                  30          

Ser Leu Val Lys Thr Ile Val Gln Ser Asp Ser Tyr Tyr Asp Val Phe 
        35                  40                  45              

Lys Asn Leu Lys Thr Tyr Lys Asp Ile Ser Leu Met Gln Ser Leu Leu 
    50                  55                  60                  

Ser Asp Ala Gly Val Ala Ser Val Pro Arg Thr Ser Tyr Leu Ser Ala 
65                  70                  75                  80  

Phe Asn Lys Met Asp Lys Thr Ala Met Tyr Asn Ala Glu Lys Gly Phe 
                85                  90                  95      

Gly Phe Gly Leu Ser Leu Phe Ser Ser Arg Thr Leu Asn Tyr Glu His 
            100                 105                 110         

Met Asn Lys Glu Asn Lys Arg Gly Trp Tyr Thr Ser Asp Gly Met Phe 
        115                 120                 125             

Tyr Leu Tyr Asn Gly Asp Leu Ser His Tyr Ser Asp Gly Tyr Trp Pro 
    130                 135                 140                 

Thr Val Asn Pro Tyr Lys Met Pro Gly Thr Thr Glu Thr Asp Ala Lys 
145                 150                 155                 160 

Arg Ala Asp Ser Asp Thr Gly Lys Val Leu Pro Ser Ala Phe Val Gly 
                165                 170                 175     

Thr Ser Lys Leu Asp Asp Ala Asn Ala Thr Ala Thr Met Asp Phe Thr 
            180                 185                 190         

Asn Trp Asn Gln Thr Leu Thr Ala His Lys Ser Trp Phe Met Leu Lys 
        195                 200                 205             

Asp Lys Ile Ala Phe Leu Gly Ser Asn Ile Gln Asn Thr Ser Thr Asp 
    210                 215                 220                 

Thr Ala Ala Thr Thr Ile Asp Gln Arg Lys Leu Glu Ser Ser Asn Pro 
225                 230                 235                 240 

Tyr Lys Val Tyr Val Asn Asp Lys Glu Ala Ser Leu Thr Glu Gln Glu 
                245                 250                 255     

Lys Asp Tyr Pro Glu Thr Gln Ser Val Phe Leu Glu Ser Ser Asp Ser 
            260                 265                 270         

Lys Lys Asn Ile Gly Tyr Phe Phe Phe Lys Lys Ser Ser Ile Ser Met 
        275                 280                 285             

Ser Lys Ala Leu Gln Lys Gly Ala Trp Lys Asp Ile Asn Glu Gly Gln 
    290                 295                 300                 

Ser Asp Lys Glu Val Glu Asn Glu Phe Leu Thr Ile Ser Gln Ala His 
305                 310                 315                 320 

Lys Gln Asn Gly Asp Ser Tyr Gly Tyr Met Leu Ile Pro Asn Val Asp 
                325                 330                 335     

Arg Ala Thr Phe Asn Gln Met Ile Lys Glu Leu Glu Ser Ser Leu Ile 
            340                 345                 350         

Glu Asn Asn Glu Thr Leu Gln Ser Val Tyr Asp Ala Lys Gln Gly Val 
        355                 360                 365             

Trp Gly Ile Val Lys Tyr Asp Asp Ser Val Ser Thr Ile Ser Asn Gln 
    370                 375                 380                 

Phe Gln Val Leu Lys Arg Gly Val Tyr Thr Ile Arg Lys Glu Gly Asp 
385                 390                 395                 400 

Glu Tyr Lys Ile Ala Tyr Tyr Asn Pro Glu Thr Gln Glu Ser Ala Pro 
                405                 410                 415     

Asp Gln Glu Val Phe Lys Lys Leu Glu Gln Ala Ala Gln Pro Gln Val 
            420                 425                 430         

Gln Asn Ser Lys Glu Lys Glu Lys Ser Glu Glu Glu Lys Asn His Ser 
        435                 440                 445             

Asp Gln Lys Asn 
    450         

<210>   184
<211>   2148
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   184
Asp Glu Thr Leu Ile Thr His Thr Ala Glu Lys Pro Lys Glu Glu Lys 
1               5                   10                  15      

Met Ile Val Glu Glu Lys Ala Asp Lys Ala Leu Glu Thr Lys Asn Val 
            20                  25                  30          

Val Glu Arg Thr Glu Gln Ser Glu Pro Ser Ser Thr Glu Ala Ile Ala 
        35                  40                  45              

Ser Glu Lys Lys Glu Asp Glu Ala Val Thr Pro Lys Glu Glu Lys Val 
    50                  55                  60                  

Ser Ala Lys Pro Glu Glu Lys Ala Pro Arg Ile Glu Ser Gln Ala Ser 
65                  70                  75                  80  

Ser Gln Glu Lys Pro Leu Lys Glu Asp Ala Lys Ala Val Thr Asn Glu 
                85                  90                  95      

Glu Val Asn Gln Met Ile Glu Asn Arg Lys Val Asp Phe Asn Gln Asn 
            100                 105                 110         

Trp Tyr Phe Lys Leu Asn Ala Asn Ser Lys Glu Ala Ile Lys Pro Asp 
        115                 120                 125             

Ala Asp Val Ser Thr Trp Lys Lys Leu Asp Leu Pro Tyr Asp Trp Ser 
    130                 135                 140                 

Ile Phe Asn Asp Phe Asp His Glu Ser Pro Ala Gln Asn Glu Gly Gly 
145                 150                 155                 160 

Gln Leu Asn Gly Gly Glu Ala Trp Tyr Arg Lys Thr Phe Lys Leu Asp 
                165                 170                 175     

Glu Lys Asp Leu Lys Lys Asn Val Arg Leu Thr Phe Asp Gly Val Tyr 
            180                 185                 190         

Met Asp Ser Gln Val Tyr Val Asn Gly Gln Leu Val Gly His Tyr Pro 
        195                 200                 205             

Asn Gly Tyr Asn Gln Phe Ser Tyr Asp Ile Thr Lys Tyr Leu Tyr Lys 
    210                 215                 220                 

Asp Gly Arg Glu Asn Val Ile Ala Val His Ala Val Asn Lys Gln Pro 
225                 230                 235                 240 

Ser Ser Arg Trp Tyr Ser Gly Ser Gly Ile Tyr Arg Asp Val Thr Leu 
                245                 250                 255     

Gln Val Thr Asp Lys Val His Val Glu Lys Asn Gly Thr Thr Ile Leu 
            260                 265                 270         

Thr Pro Lys Leu Glu Glu Gln Gln His Gly Lys Val Glu Thr His Val 
        275                 280                 285             

Thr Ser Lys Ile Val Asn Thr Asp Asp Lys Asp His Glu Leu Val Ala 
    290                 295                 300                 

Glu Tyr Gln Ile Val Glu Arg Gly Gly His Ala Val Thr Gly Leu Val 
305                 310                 315                 320 

Arg Thr Ala Ser Arg Thr Leu Lys Ala His Glu Ser Thr Ser Leu Asp 
                325                 330                 335     

Ala Ile Leu Glu Val Glu Arg Pro Lys Leu Trp Thr Val Leu Asn Asp 
            340                 345                 350         

Lys Pro Ala Leu Tyr Glu Leu Ile Thr Arg Val Tyr Arg Asp Gly Gln 
        355                 360                 365             

Leu Val Asp Ala Lys Lys Asp Leu Phe Gly Tyr Arg Tyr Tyr His Trp 
    370                 375                 380                 

Thr Pro Asn Glu Gly Phe Ser Leu Asn Gly Glu Arg Ile Lys Phe His 
385                 390                 395                 400 

Gly Val Ser Leu His His Asp His Gly Ala Leu Gly Ala Glu Glu Asn 
                405                 410                 415     

Tyr Lys Ala Glu Tyr Arg Arg Leu Lys Gln Met Lys Glu Met Gly Val 
            420                 425                 430         

Asn Ser Ile Arg Thr Thr His Asn Pro Ala Ser Glu Gln Thr Leu Gln 
        435                 440                 445             

Ile Ala Ala Glu Leu Gly Leu Leu Val Gln Glu Glu Ala Phe Asp Thr 
    450                 455                 460                 

Trp Tyr Gly Gly Lys Lys Pro Tyr Asp Tyr Gly Arg Phe Phe Glu Lys 
465                 470                 475                 480 

Asp Ala Thr His Pro Glu Ala Arg Lys Gly Glu Lys Trp Ser Asp Phe 
                485                 490                 495     

Asp Leu Arg Thr Met Val Glu Arg Gly Lys Asn Asn Pro Ala Ile Phe 
            500                 505                 510         

Met Trp Ser Ile Gly Asn Glu Ile Gly Glu Ala Asn Gly Asp Ala His 
        515                 520                 525             

Ser Leu Ala Thr Val Lys Arg Leu Val Lys Val Ile Lys Asp Val Asp 
    530                 535                 540                 

Lys Thr Arg Tyr Val Thr Met Gly Ala Asp Lys Phe Arg Phe Gly Asn 
545                 550                 555                 560 

Gly Ser Gly Gly His Glu Lys Ile Ala Asp Glu Leu Asp Ala Val Gly 
                565                 570                 575     

Phe Asn Tyr Ser Glu Asp Asn Tyr Lys Ala Leu Arg Ala Lys His Pro 
            580                 585                 590         

Lys Trp Leu Ile Tyr Gly Ser Glu Thr Ser Ser Ala Thr Arg Thr Arg 
        595                 600                 605             

Gly Ser Tyr Tyr Arg Pro Glu Arg Glu Leu Lys His Ser Asn Gly Pro 
    610                 615                 620                 

Glu Arg Asn Tyr Glu Gln Ser Asp Tyr Gly Asn Asp Arg Val Gly Trp 
625                 630                 635                 640 

Gly Lys Thr Ala Thr Ala Ser Trp Thr Phe Asp Arg Asp Asn Ala Gly 
                645                 650                 655     

Tyr Ala Gly Gln Phe Ile Trp Thr Gly Thr Asp Tyr Ile Gly Glu Pro 
            660                 665                 670         

Thr Pro Trp His Asn Gln Asn Gln Thr Pro Val Lys Ser Ser Tyr Phe 
        675                 680                 685             

Gly Ile Val Asp Thr Ala Gly Ile Pro Lys His Asp Phe Tyr Leu Tyr 
    690                 695                 700                 

Gln Ser Gln Trp Val Ser Val Lys Lys Lys Pro Met Val His Leu Leu 
705                 710                 715                 720 

Pro His Trp Asn Trp Glu Asn Lys Glu Leu Ala Ser Lys Val Ala Asp 
                725                 730                 735     

Ser Glu Gly Lys Ile Pro Val Arg Ala Tyr Ser Asn Ala Ser Ser Val 
            740                 745                 750         

Glu Leu Phe Leu Asn Gly Lys Ser Leu Gly Leu Lys Thr Phe Asn Lys 
        755                 760                 765             

Lys Gln Thr Ser Asp Gly Arg Thr Tyr Gln Glu Gly Ala Asn Ala Asn 
    770                 775                 780                 

Glu Leu Tyr Leu Glu Trp Lys Val Ala Tyr Gln Pro Gly Thr Leu Glu 
785                 790                 795                 800 

Ala Ile Ala Arg Asp Glu Ser Gly Lys Glu Ile Ala Arg Asp Lys Ile 
                805                 810                 815     

Thr Thr Ala Gly Lys Pro Ala Ala Val Arg Leu Ile Lys Glu Asp His 
            820                 825                 830         

Ala Ile Ala Ala Asp Gly Lys Asp Leu Thr Tyr Ile Tyr Tyr Glu Ile 
        835                 840                 845             

Val Asp Ser Gln Gly Asn Val Val Pro Thr Ala Asn Asn Leu Val Arg 
    850                 855                 860                 

Phe Gln Leu His Gly Gln Gly Gln Leu Val Gly Val Asp Asn Gly Glu 
865                 870                 875                 880 

Gln Ala Ser Arg Glu Arg Tyr Lys Ala Gln Ala Asp Gly Ser Trp Ile 
                885                 890                 895     

Arg Lys Ala Phe Asn Gly Lys Gly Val Ala Ile Val Lys Ser Thr Glu 
            900                 905                 910         

Gln Ala Gly Lys Phe Thr Leu Thr Ala His Ser Asp Leu Leu Lys Ser 
        915                 920                 925             

Asn Gln Val Thr Val Phe Thr Gly Lys Lys Glu Gly Gln Glu Lys Thr 
    930                 935                 940                 

Val Leu Gly Thr Glu Val Pro Lys Val Gln Thr Ile Ile Gly Glu Ala 
945                 950                 955                 960 

Pro Glu Met Pro Thr Thr Val Pro Phe Val Tyr Ser Asp Gly Ser Arg 
                965                 970                 975     

Ala Glu Arg Pro Val Thr Trp Ser Leu Val Asp Val Ser Lys Pro Gly 
            980                 985                 990         

Ile Val Thr Val Lys Gly Met Ala Asp Gly Arg Glu Val Glu Ala Arg 
        995                 1000                1005            

Val Glu Val Ile Ala Leu Lys Ser Glu Leu Pro Val Val Lys Arg Ile 
    1010                1015                1020                

Ala Pro Asn Thr Asn Leu Asn Ser Val Asp Lys Ser Val Ser Tyr Val 
1025                1030                1035                1040

Leu Thr Asp Gly Ser Val Gln Glu Tyr Glu Val Asp Lys Trp Glu Ile 
                1045                1050                1055    

Ala Glu Glu Asp Lys Ala Lys Leu Ala Ile Pro Gly Ser Arg Ile Gln 
            1060                1065                1070        

Ala Thr Gly Tyr Leu Glu Gly Gln Pro Ile His Ala Thr Leu Val Val 
        1075                1080                1085            

Glu Glu Gly Asn Pro Ala Ala Pro Val Val Pro Thr Val Thr Val Gly 
    1090                1095                1100                

Gly Glu Ala Val Thr Gly Leu Thr Ser Arg Gln Pro Met Gln Tyr Arg 
1105                1110                1115                1120

Thr Leu Ser Tyr Gly Ala Gln Leu Pro Glu Val Thr Ala Ser Ala Glu 
                1125                1130                1135    

Asn Ala Asp Val Thr Val Leu Gln Ala Ser Ala Ala Asn Gly Met Arg 
            1140                1145                1150        

Ala Ser Ile Phe Ile Gln Pro Lys Asp Gly Gly Pro Leu Gln Thr Tyr 
        1155                1160                1165            

Ala Ile Gln Phe Leu Glu Glu Ala Pro Lys Ile Ala His Leu Ser Leu 
    1170                1175                1180                

Gln Val Glu Lys Ala Asp Ser Leu Lys Glu Asp Gln Thr Val Lys Leu 
1185                1190                1195                1200

Ser Val Arg Ala His Tyr Gln Asp Gly Thr Gln Ala Val Leu Pro Ala 
                1205                1210                1215    

Asp Lys Val Thr Phe Ser Thr Ser Gly Glu Gly Glu Val Ala Ile Arg 
            1220                1225                1230        

Lys Gly Met Leu Glu Leu His Lys Pro Gly Ala Val Thr Leu Asn Ala 
        1235                1240                1245            

Glu Tyr Glu Gly Ala Lys Gly Gln Val Glu Leu Thr Ile Gln Ala Asn 
    1250                1255                1260                

Thr Glu Lys Lys Ile Ala Gln Ser Ile Arg Pro Val Asn Val Val Thr 
1265                1270                1275                1280

Asp Leu His Gln Glu Pro Ser Leu Pro Ala Thr Val Thr Val Glu Tyr 
                1285                1290                1295    

Asp Lys Gly Phe Pro Lys Thr His Lys Val Thr Trp Gln Ala Ile Pro 
            1300                1305                1310        

Lys Glu Lys Leu Asp Ser Tyr Gln Ile Phe Glu Val Leu Gly Lys Val 
        1315                1320                1325            

Glu Gly Ile Asp Leu Glu Ala Arg Ala Lys Val Ser Val Glu Gly Ile 
    1330                1335                1340                

Val Ser Val Glu Glu Val Ser Val Thr Thr Pro Ile Ala Glu Ala Pro 
1345                1350                1355                1360

Gln Leu Pro Glu Ser Val Arg Thr Tyr Asp Ser Asn Gly His Val Ser 
                1365                1370                1375    

Ser Ala Lys Val Ala Trp Asp Ala Ile Arg Pro Glu Gln Tyr Ala Lys 
            1380                1385                1390        

Glu Gly Val Phe Thr Val Asn Gly Arg Leu Glu Gly Thr Gln Leu Thr 
        1395                1400                1405            

Thr Lys Leu His Val Arg Val Ser Ala Gln Thr Glu Gln Gly Ala Asn 
    1410                1415                1420                

Ile Ser Asp Gln Trp Thr Gly Ser Glu Leu Pro Leu Ala Phe Ala Ser 
1425                1430                1435                1440

Asp Ser Asn Pro Ser Asp Pro Val Ser Asn Val Asn Asp Lys Leu Ile 
                1445                1450                1455    

Ser Tyr Asn Asn Gln Pro Ala Asn Arg Trp Thr Asn Trp Asn Arg Ser 
            1460                1465                1470        

Asn Pro Glu Ala Ser Val Gly Val Leu Phe Gly Asp Ser Gly Ile Leu 
        1475                1480                1485            

Ser Lys Arg Ser Val Asp Asn Leu Ser Val Gly Phe His Glu Asp His 
    1490                1495                1500                

Gly Val Gly Ala Pro Lys Ser Tyr Val Ile Glu Tyr Tyr Val Gly Lys 
1505                1510                1515                1520

Thr Val Pro Thr Ala Pro Lys Asn Pro Ser Phe Val Gly Asn Glu Asp 
                1525                1530                1535    

His Val Phe Asn Asp Ser Ala Asn Trp Lys Pro Val Thr Asn Leu Lys 
            1540                1545                1550        

Ala Pro Ala Gln Leu Lys Ala Gly Glu Met Asn His Phe Ser Phe Asp 
        1555                1560                1565            

Lys Val Glu Thr Tyr Ala Ile Arg Ile Arg Met Val Lys Ala Asp Asn 
    1570                1575                1580                

Lys Arg Gly Thr Ser Ile Thr Glu Val Gln Ile Phe Ala Lys Gln Val 
1585                1590                1595                1600

Ala Ala Ala Lys Gln Gly Gln Thr Arg Ile Gln Val Asp Gly Lys Asp 
                1605                1610                1615    

Leu Ala Asn Phe Asn Pro Asp Leu Thr Asp Tyr Tyr Leu Glu Ser Val 
            1620                1625                1630        

Asp Gly Lys Val Pro Ala Val Thr Ala Asn Val Ser Asn Asn Gly Leu 
        1635                1640                1645            

Ala Thr Val Val Pro Ser Val Arg Glu Gly Glu Pro Val Arg Val Ile 
    1650                1655                1660                

Ala Lys Ala Glu Asn Gly Asp Ile Leu Gly Glu Tyr Arg Leu His Phe 
1665                1670                1675                1680

Thr Lys Asp Lys Asn Leu Leu Ser His Lys Pro Val Ala Ala Val Lys 
                1685                1690                1695    

Gln Ala Arg Leu Leu Gln Val Gly Gln Ala Leu Glu Leu Pro Thr Lys 
            1700                1705                1710        

Val Pro Val Tyr Phe Thr Gly Lys Asp Gly Tyr Glu Thr Lys Asp Leu 
        1715                1720                1725            

Thr Val Glu Trp Glu Glu Val Pro Ala Glu Asn Leu Thr Lys Ala Gly 
    1730                1735                1740                

Gln Phe Thr Val Arg Gly Arg Val Leu Gly Ser Asn Leu Val Ala Glu 
1745                1750                1755                1760

Val Thr Val Arg Val Thr Asp Lys Leu Gly Glu Thr Leu Ser Asp Asn 
                1765                1770                1775    

Pro Asn Tyr Asp Glu Asn Ser Asn Gln Ala Phe Ala Ser Ala Thr Asn 
            1780                1785                1790        

Asp Ile Asp Lys Asn Ser His Asp Arg Val Asp Tyr Leu Asn Asp Gly 
        1795                1800                1805            

Asp His Ser Glu Asn Arg Arg Trp Thr Asn Trp Ser Pro Thr Pro Ser 
    1810                1815                1820                

Ser Asn Pro Glu Val Ser Ala Gly Val Ile Phe Arg Glu Asn Gly Lys 
1825                1830                1835                1840

Ile Val Glu Arg Thr Val Ala Gln Ala Lys Leu His Phe Phe Ala Asp 
                1845                1850                1855    

Ser Gly Thr Asp Ala Pro Ser Lys Leu Val Leu Glu Arg Tyr Val Gly 
            1860                1865                1870        

Pro Gly Phe Glu Val Pro Thr Tyr Tyr Ser Asn Tyr Gln Ala Tyr Glu 
        1875                1880                1885            

Ser Gly His Pro Phe Asn Asn Pro Glu Asn Trp Glu Ala Val Pro Tyr 
    1890                1895                1900                

Arg Ala Asp Lys Asp Ile Ala Ala Gly Asp Glu Ile Asn Val Thr Phe 
1905                1910                1915                1920

Lys Ala Val Lys Ala Lys Val Met Arg Trp Arg Met Glu Arg Lys Ala 
                1925                1930                1935    

Asp Lys Ser Gly Val Ala Met Ile Glu Met Thr Phe Leu Ala Pro Ser 
            1940                1945                1950        

Glu Leu Pro Gln Glu Ser Thr Gln Ser Lys Ile Leu Val Asp Gly Lys 
        1955                1960                1965            

Glu Leu Ala Asp Phe Ala Glu Asn Arg Gln Asp Tyr Gln Ile Thr Tyr 
    1970                1975                1980                

Lys Gly Gln Arg Pro Lys Val Ser Val Glu Glu Asn Asn Gln Val Ala 
1985                1990                1995                2000

Ser Thr Val Val Asp Ser Gly Glu Asp Ser Leu Pro Val Leu Val Arg 
                2005                2010                2015    

Leu Val Ser Glu Ser Gly Lys Gln Val Lys Glu Tyr Arg Ile Gln Leu 
            2020                2025                2030        

Thr Lys Glu Lys Pro Val Ser Ala Val Gln Glu Asp Leu Pro Lys Leu 
        2035                2040                2045            

Glu Phe Val Glu Lys Asp Leu Ala Tyr Lys Thr Val Glu Lys Lys Asp 
    2050                2055                2060                

Ser Thr Leu Tyr Leu Gly Glu Thr Arg Val Glu Gln Glu Gly Lys Val 
2065                2070                2075                2080

Gly Lys Glu Arg Ile Phe Thr Val Ile Asn Pro Asp Gly Ser Lys Glu 
                2085                2090                2095    

Glu Lys Leu Arg Glu Val Val Glu Val Pro Thr Asp Arg Ile Val Leu 
            2100                2105                2110        

Val Gly Thr Lys Pro Val Ala Gln Glu Ala Lys Lys Pro Gln Val Ser 
        2115                2120                2125            

Glu Lys Ala Asp Thr Lys Pro Ile Asp Ser Ser Glu Ala Asp Gln Thr 
    2130                2135                2140                

Asn Lys Ala Gln 
2145            

<210>   185
<211>   680
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   185
Ala Ser Asp Gly Thr Trp Gln Gly Lys Gln Tyr Leu Lys Glu Asp Gly 
1               5                   10                  15      

Ser Gln Ala Ala Asn Glu Trp Val Phe Asp Thr His Tyr Gln Ser Trp 
            20                  25                  30          

Phe Tyr Ile Lys Ala Asp Ala Asn Tyr Ala Glu Asn Glu Trp Leu Lys 
        35                  40                  45              

Gln Gly Asp Asp Tyr Phe Tyr Leu Lys Ser Gly Gly Tyr Met Ala Lys 
    50                  55                  60                  

Ser Glu Trp Val Glu Asp Lys Gly Ala Phe Tyr Tyr Leu Asp Gln Asp 
65                  70                  75                  80  

Gly Lys Met Lys Arg Asn Ala Trp Val Gly Thr Ser Tyr Val Gly Ala 
                85                  90                  95      

Thr Gly Ala Lys Val Ile Glu Asp Trp Val Tyr Asp Ser Gln Tyr Asp 
            100                 105                 110         

Ala Trp Phe Tyr Ile Lys Ala Asp Gly Gln His Ala Glu Lys Glu Trp 
        115                 120                 125             

Leu Gln Ile Lys Gly Lys Asp Tyr Tyr Phe Lys Ser Gly Gly Tyr Leu 
    130                 135                 140                 

Leu Thr Ser Gln Trp Ile Asn Gln Ala Tyr Val Asn Ala Ser Gly Ala 
145                 150                 155                 160 

Lys Val Gln Gln Gly Trp Leu Phe Asp Lys Gln Tyr Gln Ser Trp Phe 
                165                 170                 175     

Tyr Ile Lys Glu Asn Gly Asn Tyr Ala Asp Lys Glu Trp Ile Phe Glu 
            180                 185                 190         

Asn Gly His Tyr Tyr Tyr Leu Lys Ser Gly Gly Tyr Met Ala Ala Asn 
        195                 200                 205             

Glu Trp Ile Trp Asp Lys Glu Ser Trp Phe Tyr Leu Lys Phe Asp Gly 
    210                 215                 220                 

Lys Ile Ala Glu Lys Glu Trp Val Tyr Asp Ser His Ser Gln Ala Trp 
225                 230                 235                 240 

Tyr Tyr Phe Lys Ser Gly Gly Tyr Met Ala Ala Asn Glu Trp Ile Trp 
                245                 250                 255     

Asp Lys Glu Ser Trp Phe Tyr Leu Lys Phe Asp Gly Lys Met Ala Glu 
            260                 265                 270         

Lys Glu Trp Val Tyr Asp Ser His Ser Gln Ala Trp Tyr Tyr Phe Lys 
        275                 280                 285             

Ser Gly Gly Tyr Met Thr Ala Asn Glu Trp Ile Trp Asp Lys Glu Ser 
    290                 295                 300                 

Trp Phe Tyr Leu Lys Ser Asp Gly Lys Ile Ala Glu Lys Glu Trp Val 
305                 310                 315                 320 

Tyr Asp Ser His Ser Gln Ala Trp Tyr Tyr Phe Lys Ser Gly Gly Tyr 
                325                 330                 335     

Met Thr Ala Asn Glu Trp Ile Trp Asp Lys Glu Ser Trp Phe Tyr Leu 
            340                 345                 350         

Lys Ser Asp Gly Lys Met Ala Glu Lys Glu Trp Val Tyr Asp Ser His 
        355                 360                 365             

Ser Gln Ala Trp Tyr Tyr Phe Lys Ser Gly Gly Tyr Met Ala Lys Asn 
    370                 375                 380                 

Glu Thr Val Asp Gly Tyr Gln Leu Gly Ser Asp Gly Lys Trp Leu Gly 
385                 390                 395                 400 

Gly Lys Ala Thr Asn Lys Asn Ala Ala Tyr Tyr Gln Val Val Pro Val 
                405                 410                 415     

Thr Ala Asn Val Tyr Asp Ser Asp Gly Glu Lys Leu Ser Tyr Ile Ser 
            420                 425                 430         

Gln Gly Ser Val Val Trp Leu Asp Lys Asp Arg Lys Ser Asp Asp Lys 
        435                 440                 445             

Arg Leu Ala Ile Thr Ile Ser Gly Leu Ser Gly Tyr Met Lys Thr Glu 
    450                 455                 460                 

Asp Leu Gln Ala Leu Asp Ala Ser Lys Asp Phe Ile Pro Tyr Tyr Glu 
465                 470                 475                 480 

Ser Asp Gly His Arg Phe Tyr His Tyr Val Ala Gln Asn Ala Ser Ile 
                485                 490                 495     

Pro Val Ala Ser His Leu Ser Asp Met Glu Val Gly Lys Lys Tyr Tyr 
            500                 505                 510         

Ser Ala Asp Gly Leu His Phe Asp Gly Phe Lys Leu Glu Asn Pro Phe 
        515                 520                 525             

Leu Phe Lys Asp Leu Thr Glu Ala Thr Asn Tyr Ser Ala Glu Glu Leu 
    530                 535                 540                 

Asp Lys Val Phe Ser Leu Leu Asn Ile Asn Asn Ser Leu Leu Glu Asn 
545                 550                 555                 560 

Lys Gly Ala Thr Phe Lys Glu Ala Glu Glu His Tyr His Ile Asn Ala 
                565                 570                 575     

Leu Tyr Leu Leu Ala His Ser Ala Leu Glu Ser Asn Trp Gly Arg Ser 
            580                 585                 590         

Lys Ile Ala Lys Asp Lys Asn Asn Phe Phe Gly Ile Thr Ala Tyr Asp 
        595                 600                 605             

Thr Thr Pro Tyr Leu Ser Ala Lys Thr Phe Asp Asp Val Asp Lys Gly 
    610                 615                 620                 

Ile Leu Gly Ala Thr Lys Trp Ile Lys Glu Asn Tyr Ile Asp Arg Gly 
625                 630                 635                 640 

Arg Thr Phe Leu Gly Asn Lys Ala Ser Gly Met Asn Val Glu Tyr Ala 
                645                 650                 655     

Ser Asp Pro Tyr Trp Gly Glu Lys Ile Ala Ser Val Met Met Lys Ile 
            660                 665                 670         

Asn Glu Lys Leu Gly Gly Lys Asp 
        675                 680 

<210>   186
<211>   294
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   186
Ala Cys Ser Lys Gly Ser Glu Gly Ala Asp Leu Ile Ser Met Lys Gly 
1               5                   10                  15      

Asp Val Ile Thr Glu His Gln Phe Tyr Glu Gln Val Lys Asn Asn Pro 
            20                  25                  30          

Ser Ala Gln Gln Val Leu Leu Asn Met Thr Ile Gln Lys Val Phe Glu 
        35                  40                  45              

Lys Gln Tyr Gly Ser Glu Leu Asp Asp Lys Glu Val Asp Asp Thr Ile 
    50                  55                  60                  

Ala Glu Glu Lys Lys Gln Tyr Gly Glu Asn Tyr Gln Arg Val Leu Ser 
65                  70                  75                  80  

Gln Ala Gly Met Thr Leu Glu Thr Arg Lys Ala Gln Ile Arg Thr Ser 
                85                  90                  95      

Lys Leu Val Glu Leu Ala Val Lys Lys Val Ala Glu Ala Glu Leu Thr 
            100                 105                 110         

Asp Glu Ala Tyr Lys Lys Ala Phe Asp Glu Tyr Thr Pro Asp Val Thr 
        115                 120                 125             

Ala Gln Ile Ile Arg Leu Asn Asn Glu Asp Lys Ala Lys Glu Val Leu 
    130                 135                 140                 

Glu Lys Ala Lys Ala Glu Gly Ala Asp Phe Ala Gln Leu Ala Lys Asp 
145                 150                 155                 160 

Asn Ser Thr Asp Glu Lys Thr Lys Glu Asn Gly Gly Glu Ile Thr Phe 
                165                 170                 175     

Asp Ser Ala Ser Thr Glu Val Pro Glu Gln Val Lys Lys Ala Ala Phe 
            180                 185                 190         

Ala Leu Asp Val Asp Gly Val Ser Asp Val Ile Thr Ala Thr Gly Thr 
        195                 200                 205             

Gln Ala Tyr Ser Ser Gln Tyr Tyr Ile Val Lys Leu Thr Lys Lys Thr 
    210                 215                 220                 

Glu Lys Ser Ser Asn Ile Asp Asp Tyr Lys Glu Lys Leu Lys Thr Val 
225                 230                 235                 240 

Ile Leu Thr Gln Lys Gln Asn Asp Ser Thr Phe Val Gln Ser Ile Ile 
                245                 250                 255     

Gly Lys Glu Leu Gln Ala Ala Asn Ile Lys Val Lys Asp Gln Ala Phe 
            260                 265                 270         

Gln Asn Ile Phe Thr Gln Tyr Ile Gly Gly Gly Asp Ser Ser Ser Ser 
        275                 280                 285             

Ser Ser Thr Ser Asn Glu 
    290                 

<210>   187
<211>   218
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   187
Ala Leu Ile Phe Asn Thr Gln Ile Arg Asn Ile Phe Ile Val Trp Asn 
1               5                   10                  15      

Thr Asn Lys Tyr Gln Val Ser Gln Val Ser Lys Glu Lys Leu Glu Glu 
            20                  25                  30          

Asn Gln Asp Thr Glu Gly Asn Phe Asp Phe Asp Ser Val Lys Ala Ile 
        35                  40                  45              

Ser Ser Glu Ala Val Leu Thr Ser Gln Trp Asp Ala Gln Lys Leu Pro 
    50                  55                  60                  

Val Ile Gly Gly Ile Ala Ile Pro Glu Leu Glu Met Asn Leu Pro Ile 
65                  70                  75                  80  

Phe Lys Gly Leu Asp Asn Val Asn Leu Phe Tyr Gly Ala Gly Thr Met 
                85                  90                  95      

Lys Arg Glu Gln Val Met Gly Glu Gly Asn Tyr Ser Leu Ala Ser His 
            100                 105                 110         

His Ile Phe Gly Val Asp Asn Ala Asn Lys Met Leu Phe Ser Pro Leu 
        115                 120                 125             

Asp Asn Ala Lys Asn Gly Met Lys Ile Tyr Leu Thr Asp Lys Asn Lys 
    130                 135                 140                 

Val Tyr Thr Tyr Glu Ile Arg Glu Val Lys Arg Val Thr Pro Asp Arg 
145                 150                 155                 160 

Val Asp Glu Val Asp Asp Arg Asp Gly Val Asn Glu Ile Thr Leu Val 
                165                 170                 175     

Thr Cys Glu Asp Leu Ala Ala Thr Glu Arg Ile Ile Val Lys Gly Asp 
            180                 185                 190         

Leu Lys Glu Thr Lys Asp Tyr Ser Gln Thr Ser Asp Glu Ile Leu Thr 
        195                 200                 205             

Ala Phe Asn Gln Pro Tyr Lys Gln Phe Tyr 
    210                 215             

<210>   188
<211>   165
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   188
Val Pro Lys Thr Ala Thr Ser Thr Glu Thr Lys Thr Ile Thr Arg Ile 
1               5                   10                  15      

Ile His Tyr Val Asp Lys Val Thr Asn Gln Asn Val Lys Glu Asp Val 
            20                  25                  30          

Val Gln Pro Val Thr Leu Ser Arg Thr Lys Thr Glu Asn Lys Val Thr 
        35                  40                  45              

Gly Val Val Thr Tyr Gly Glu Trp Thr Thr Gly Asn Trp Asp Glu Val 
    50                  55                  60                  

Ile Ser Gly Lys Ile Asp Lys Tyr Lys Asp Pro Asp Ile Pro Thr Val 
65                  70                  75                  80  

Glu Ser Gln Glu Val Thr Ser Asp Ser Ser Asp Lys Glu Ile Thr Val 
                85                  90                  95      

Arg Tyr Asp Arg Leu Ser Thr Pro Glu Lys Pro Ile Pro Gln Pro Asn 
            100                 105                 110         

Pro Glu His Pro Ser Val Pro Thr Pro Asn Pro Glu Leu Pro Asn Gln 
        115                 120                 125             

Glu Thr Pro Thr Pro Asp Lys Pro Thr Pro Glu Pro Gly Thr Pro Lys 
    130                 135                 140                 

Thr Glu Thr Pro Val Asn Pro Asp Pro Glu Val Pro Thr Tyr Glu Thr 
145                 150                 155                 160 

Gly Lys Arg Glu Glu 
                165 

<210>   189
<211>   469
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   189
Ala Asn Glu Thr Glu Val Ala Lys Thr Ser Gln Asp Thr Thr Thr Ala 
1               5                   10                  15      

Ser Ser Ser Ser Glu Gln Asn Gln Ser Ser Asn Lys Thr Gln Thr Ser 
            20                  25                  30          

Ala Glu Val Gln Thr Asn Ala Ala Ala Tyr Trp Asp Gly Asp Tyr Tyr 
        35                  40                  45              

Val Lys Asp Asp Gly Ser Lys Ala Gln Ser Glu Trp Ile Phe Asp Asn 
    50                  55                  60                  

Tyr Tyr Lys Ala Trp Phe Tyr Ile Asn Ser Asp Gly Arg Tyr Ser Gln 
65                  70                  75                  80  

Asn Glu Trp His Gly Asn Tyr Tyr Leu Lys Ser Gly Gly Tyr Met Ala 
                85                  90                  95      

Gln Asn Glu Trp Ile Tyr Asp Ser Asn Tyr Lys Ser Trp Phe Tyr Leu 
            100                 105                 110         

Lys Ser Asp Gly Ala Tyr Ala His Gln Glu Trp Gln Leu Ile Gly Asn 
        115                 120                 125             

Lys Trp Tyr Tyr Phe Lys Lys Trp Gly Tyr Met Ala Lys Ser Gln Trp 
    130                 135                 140                 

Gln Gly Ser Tyr Phe Leu Asn Gly Gln Gly Ala Met Ile Gln Asn Glu 
145                 150                 155                 160 

Trp Leu Tyr Asp Pro Ala Tyr Ser Ala Tyr Phe Tyr Leu Lys Ser Asp 
                165                 170                 175     

Gly Thr Tyr Ala Asn Gln Glu Trp Gln Lys Val Gly Gly Lys Trp Tyr 
            180                 185                 190         

Tyr Phe Lys Lys Trp Gly Tyr Met Ala Arg Asn Glu Trp Gln Gly Asn 
        195                 200                 205             

Tyr Tyr Leu Thr Gly Ser Gly Ala Met Ala Thr Asp Glu Val Ile Met 
    210                 215                 220                 

Asp Gly Ala Arg Tyr Ile Phe Ala Ala Ser Gly Glu Leu Lys Glu Lys 
225                 230                 235                 240 

Lys Asp Leu Asn Val Gly Trp Val His Arg Asp Gly Lys Arg Tyr Phe 
                245                 250                 255     

Phe Asn Asn Arg Glu Glu Gln Val Gly Thr Glu His Ala Lys Lys Ile 
            260                 265                 270         

Ile Asp Ile Ser Glu His Asn Gly Arg Ile Asn Asp Trp Lys Lys Val 
        275                 280                 285             

Ile Asp Glu Asn Lys Val Asp Gly Val Ile Val Arg Leu Gly Tyr Ser 
    290                 295                 300                 

Gly Lys Glu Asp Lys Glu Leu Ala His Asn Ile Lys Glu Leu Asn Arg 
305                 310                 315                 320 

Leu Gly Ile Pro Tyr Gly Val Tyr Leu Tyr Thr Tyr Ala Glu Asn Glu 
                325                 330                 335     

Thr Asp Ala Glu Asn Asp Ala Lys Gln Thr Ile Glu Leu Ile Lys Lys 
            340                 345                 350         

Tyr Asn Met Asn Leu Ser Tyr Pro Ile Tyr Tyr Asp Val Glu Asn Trp 
        355                 360                 365             

Glu Tyr Val Asn Lys Ser Lys Arg Ala Pro Ser Asp Thr Asp Thr Trp 
    370                 375                 380                 

Val Lys Ile Ile Asn Lys Tyr Met Asp Thr Met Lys Gln Ala Gly Tyr 
385                 390                 395                 400 

Gln Asn Val Tyr Val Tyr Ser Tyr Arg Ser Leu Leu Gln Thr Arg Leu 
                405                 410                 415     

Lys His Pro Asp Ile Leu Lys His Val Asn Trp Val Ala Ala Tyr Thr 
            420                 425                 430         

Asn Ala Leu Glu Trp Glu Asn Pro Tyr Tyr Ser Gly Glu Lys Gly Trp 
        435                 440                 445             

Gln Tyr Thr Ser Ser Glu Tyr Met Lys Gly Ile Gln Gly Arg Val Asp 
    450                 455                 460                 

Val Ser Val Trp Tyr 
465                 

<210>   190
<211>   366
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   190
Ala Glu Thr Thr Asp Asp Lys Ile Ala Ala Gln Asp Asn Lys Ile Ser 
1               5                   10                  15      

Asn Leu Thr Ala Gln Gln Gln Glu Ala Gln Lys Gln Val Asp Gln Ile 
            20                  25                  30          

Gln Glu Gln Val Ser Ala Ile Gln Ala Glu Gln Ser Asn Leu Gln Ala 
        35                  40                  45              

Glu Asn Asp Arg Leu Gln Ala Glu Ser Lys Lys Leu Glu Gly Glu Ile 
    50                  55                  60                  

Thr Glu Leu Ser Lys Asn Ile Val Ser Arg Asn Gln Ser Leu Glu Lys 
65                  70                  75                  80  

Gln Ala Arg Ser Ala Gln Thr Asn Gly Ala Val Thr Ser Tyr Ile Asn 
                85                  90                  95      

Thr Ile Val Asn Ser Lys Ser Ile Thr Glu Ala Ile Ser Arg Val Ala 
            100                 105                 110         

Ala Met Ser Glu Ile Val Ser Ala Asn Asn Lys Met Leu Glu Gln Gln 
        115                 120                 125             

Lys Ala Asp Lys Lys Ala Ile Ser Glu Lys Gln Val Ala Asn Asn Asp 
    130                 135                 140                 

Ala Ile Asn Thr Val Ile Ala Asn Gln Gln Lys Leu Ala Asp Asp Ala 
145                 150                 155                 160 

Gln Ala Leu Thr Thr Lys Gln Ala Glu Leu Lys Ala Ala Glu Leu Ser 
                165                 170                 175     

Leu Ala Ala Glu Lys Ala Thr Ala Glu Gly Glu Lys Ala Ser Leu Leu 
            180                 185                 190         

Glu Gln Lys Ala Ala Ala Glu Ala Glu Ala Arg Ala Ala Ala Val Ala 
        195                 200                 205             

Glu Ala Ala Tyr Lys Glu Lys Arg Ala Ser Gln Gln Gln Ser Val Leu 
    210                 215                 220                 

Ala Ser Ala Asn Thr Asn Leu Thr Ala Gln Val Gln Ala Val Ser Glu 
225                 230                 235                 240 

Ser Ala Ala Ala Pro Val Arg Ala Lys Val Arg Pro Thr Tyr Ser Thr 
                245                 250                 255     

Asn Ala Ser Ser Tyr Pro Ile Gly Glu Cys Thr Trp Gly Val Lys Thr 
            260                 265                 270         

Leu Ala Pro Trp Ala Gly Asp Tyr Trp Gly Asn Gly Ala Gln Trp Ala 
        275                 280                 285             

Thr Ser Ala Ala Ala Ala Gly Phe Arg Thr Gly Ser Thr Pro Gln Val 
    290                 295                 300                 

Gly Ala Ile Ala Cys Trp Asn Asp Gly Gly Tyr Gly His Val Ala Val 
305                 310                 315                 320 

Val Thr Ala Val Glu Ser Thr Thr Arg Ile Gln Val Ser Glu Ser Asn 
                325                 330                 335     

Tyr Ala Gly Asn Arg Thr Ile Gly Asn His Arg Gly Trp Phe Asn Pro 
            340                 345                 350         

Thr Thr Thr Ser Glu Gly Phe Val Thr Tyr Ile Tyr Ala Asp 
        355                 360                 365     

<210>   191
<211>   821
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   191
Glu Thr Pro Glu Thr Ser Pro Ala Ile Gly Lys Val Val Ile Lys Glu 
1               5                   10                  15      

Thr Gly Glu Gly Gly Ala Leu Leu Gly Asp Ala Val Phe Glu Leu Lys 
            20                  25                  30          

Asn Asn Thr Asp Gly Thr Thr Val Ser Gln Arg Thr Glu Ala Gln Thr 
        35                  40                  45              

Gly Glu Ala Ile Phe Ser Asn Ile Lys Pro Gly Thr Tyr Thr Leu Thr 
    50                  55                  60                  

Glu Ala Gln Pro Pro Val Gly Tyr Lys Pro Ser Thr Lys Gln Trp Thr 
65                  70                  75                  80  

Val Glu Val Glu Lys Asn Gly Arg Thr Thr Val Gln Gly Glu Gln Val 
                85                  90                  95      

Glu Asn Arg Glu Glu Ala Leu Ser Asp Gln Tyr Pro Gln Thr Gly Thr 
            100                 105                 110         

Tyr Pro Asp Val Gln Thr Pro Tyr Gln Ile Ile Lys Val Asp Gly Ser 
        115                 120                 125             

Glu Lys Asn Gly Gln His Lys Ala Leu Asn Pro Asn Pro Tyr Glu Arg 
    130                 135                 140                 

Val Ile Pro Glu Gly Thr Leu Ser Lys Arg Ile Tyr Gln Val Asn Asn 
145                 150                 155                 160 

Leu Asp Asp Asn Gln Tyr Gly Ile Glu Leu Thr Val Ser Gly Lys Thr 
                165                 170                 175     

Thr Val Glu Thr Lys Glu Ala Ser Thr Pro Leu Asp Val Val Ile Leu 
            180                 185                 190         

Leu Asp Asn Ser Asn Ser Met Ser Asn Ile Arg His Asn His Ala His 
        195                 200                 205             

Arg Ala Glu Lys Ala Gly Glu Ala Thr Arg Ala Leu Val Asp Lys Ile 
    210                 215                 220                 

Thr Ser Asn Pro Asp Asn Arg Val Ala Leu Val Thr Tyr Gly Ser Thr 
225                 230                 235                 240 

Ile Phe Asp Gly Ser Glu Ala Thr Val Glu Lys Gly Val Ala Asp Ala 
                245                 250                 255     

Asn Gly Lys Ile Leu Asn Asp Ser Ala Leu Trp Thr Phe Asp Arg Thr 
            260                 265                 270         

Thr Phe Thr Ala Lys Thr Tyr Asn Tyr Ser Phe Leu Asn Leu Thr Ser 
        275                 280                 285             

Asp Pro Thr Asp Ile Gln Thr Ile Lys Asp Arg Ile Pro Ser Asp Ala 
    290                 295                 300                 

Glu Glu Leu Asn Lys Asp Lys Leu Met Tyr Gln Phe Gly Ala Thr Phe 
305                 310                 315                 320 

Thr Gln Lys Ala Leu Met Thr Ala Asp Asp Ile Leu Thr Lys Gln Ala 
                325                 330                 335     

Arg Pro Asn Ser Lys Lys Val Ile Phe His Ile Thr Asp Gly Val Pro 
            340                 345                 350         

Thr Met Ser Tyr Pro Ile Asn Phe Lys Tyr Thr Gly Thr Thr Gln Ser 
        355                 360                 365             

Tyr Arg Thr Gln Leu Asn Asn Phe Lys Ala Lys Thr Pro Asn Ser Ser 
    370                 375                 380                 

Gly Ile Leu Leu Glu Asp Phe Val Thr Trp Ser Ala Asp Gly Glu His 
385                 390                 395                 400 

Lys Ile Val Arg Gly Asp Gly Glu Ser Tyr Gln Met Phe Thr Lys Lys 
                405                 410                 415     

Pro Val Thr Asp Gln Tyr Gly Val His Gln Ile Leu Ser Ile Thr Ser 
            420                 425                 430         

Met Glu Gln Arg Ala Lys Leu Val Ser Ala Gly Tyr Arg Phe Tyr Gly 
        435                 440                 445             

Thr Asp Leu Tyr Leu Tyr Trp Arg Asp Ser Ile Leu Ala Tyr Pro Phe 
    450                 455                 460                 

Asn Ser Ser Thr Asp Trp Ile Thr Asn His Gly Asp Pro Thr Thr Trp 
465                 470                 475                 480 

Tyr Tyr Asn Gly Asn Met Ala Gln Asp Gly Tyr Asp Val Phe Thr Val 
                485                 490                 495     

Gly Val Gly Val Asn Gly Asp Pro Gly Thr Asp Glu Ala Thr Ala Thr 
            500                 505                 510         

Arg Phe Met Gln Ser Ile Ser Ser Ser Pro Asp Asn Tyr Thr Asn Val 
        515                 520                 525             

Ala Asp Pro Ser Gln Ile Leu Gln Glu Leu Asn Arg Tyr Phe Tyr Thr 
    530                 535                 540                 

Ile Val Asn Glu Lys Lys Ser Ile Glu Asn Gly Thr Ile Thr Asp Pro 
545                 550                 555                 560 

Met Gly Glu Leu Ile Asp Phe Gln Leu Gly Ala Asp Gly Arg Phe Asp 
                565                 570                 575     

Pro Ala Asp Tyr Thr Leu Thr Ala Asn Asp Gly Ser Ser Leu Val Asn 
            580                 585                 590         

Asn Val Pro Thr Gly Gly Pro Gln Asn Asp Gly Gly Leu Leu Lys Asn 
        595                 600                 605             

Ala Lys Val Phe Tyr Asp Thr Thr Glu Lys Arg Ile Arg Val Thr Gly 
    610                 615                 620                 

Leu Tyr Leu Gly Thr Gly Glu Lys Val Thr Leu Thr Tyr Asn Val Arg 
625                 630                 635                 640 

Leu Asn Asp Gln Phe Val Ser Asn Lys Phe Tyr Asp Thr Asn Gly Arg 
                645                 650                 655     

Thr Thr Leu His Pro Lys Glu Val Glu Lys Asn Thr Val Arg Asp Phe 
            660                 665                 670         

Pro Ile Pro Lys Ile Arg Asp Val Arg Lys Tyr Pro Glu Ile Thr Ile 
        675                 680                 685             

Pro Lys Glu Lys Lys Leu Gly Glu Ile Glu Phe Ile Lys Ile Asn Lys 
    690                 695                 700                 

Asn Asp Lys Lys Pro Leu Arg Asp Ala Val Phe Ser Leu Gln Lys Gln 
705                 710                 715                 720 

His Pro Asp Tyr Pro Asp Ile Tyr Gly Ala Ile Asp Gln Asn Gly Thr 
                725                 730                 735     

Tyr Gln Asn Val Arg Thr Gly Glu Asp Gly Lys Leu Thr Phe Lys Asn 
            740                 745                 750         

Leu Ser Asp Gly Lys Tyr Arg Leu Phe Glu Asn Ser Glu Pro Ala Gly 
        755                 760                 765             

Tyr Lys Pro Val Gln Asn Lys Pro Ile Val Ala Phe Gln Ile Val Asn 
    770                 775                 780                 

Gly Glu Val Arg Asp Val Thr Ser Ile Val Pro Gln Asp Ile Pro Ala 
785                 790                 795                 800 

Gly Tyr Glu Phe Thr Asn Asp Lys His Tyr Ile Thr Asn Glu Pro Ile 
                805                 810                 815     

Pro Pro Lys Arg Glu 
            820     

<210>   192
<211>   824
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   192
Glu Thr Pro Glu Thr Ser Pro Ala Ile Gly Lys Val Val Ile Lys Glu 
1               5                   10                  15      

Thr Gly Glu Gly Gly Ala Leu Leu Gly Asp Ala Val Phe Glu Leu Lys 
            20                  25                  30          

Asn Asn Thr Asp Gly Thr Thr Val Ser Gln Arg Thr Glu Ala Gln Thr 
        35                  40                  45              

Gly Glu Ala Ile Phe Ser Asn Ile Lys Pro Gly Thr Tyr Thr Leu Thr 
    50                  55                  60                  

Glu Ala Gln Pro Pro Val Gly Tyr Lys Pro Ser Thr Lys Gln Trp Thr 
65                  70                  75                  80  

Val Glu Val Glu Lys Asn Gly Arg Thr Thr Val Gln Gly Glu Gln Val 
                85                  90                  95      

Glu Asn Arg Glu Glu Ala Leu Ser Asp Gln Tyr Pro Gln Thr Gly Thr 
            100                 105                 110         

Tyr Pro Asp Val Gln Thr Pro Tyr Gln Ile Ile Lys Val Asp Gly Ser 
        115                 120                 125             

Glu Lys Asn Gly Gln His Lys Ala Leu Asn Pro Asn Pro Tyr Glu Arg 
    130                 135                 140                 

Val Ile Pro Glu Gly Thr Leu Ser Lys Arg Ile Tyr Gln Val Asn Asn 
145                 150                 155                 160 

Leu Asp Asp Asn Gln Tyr Gly Ile Glu Leu Thr Val Ser Gly Lys Thr 
                165                 170                 175     

Val Tyr Glu Gln Lys Asp Lys Ser Val Pro Leu Asp Val Val Ile Leu 
            180                 185                 190         

Leu Asp Asn Ser Asn Ser Met Ser Asn Ile Arg Asn Lys Asn Ala Arg 
        195                 200                 205             

Arg Ala Glu Arg Ala Gly Glu Ala Thr Arg Ser Leu Ile Asp Lys Ile 
    210                 215                 220                 

Thr Ser Asp Ser Glu Asn Arg Val Ala Leu Val Thr Tyr Ala Ser Thr 
225                 230                 235                 240 

Ile Phe Asp Gly Thr Glu Phe Thr Val Glu Lys Gly Val Ala Asp Lys 
                245                 250                 255     

Asn Gly Lys Arg Leu Asn Asp Ser Leu Phe Trp Asn Tyr Asp Gln Thr 
            260                 265                 270         

Ser Phe Thr Thr Asn Thr Lys Asp Tyr Ser Tyr Leu Lys Leu Thr Asn 
        275                 280                 285             

Asp Lys Asn Asp Ile Val Glu Leu Lys Asn Lys Val Pro Thr Glu Ala 
    290                 295                 300                 

Glu Asp His Asp Gly Asn Arg Leu Met Tyr Gln Phe Gly Ala Thr Phe 
305                 310                 315                 320 

Thr Gln Lys Ala Leu Met Lys Ala Asp Glu Ile Leu Thr Gln Gln Ala 
                325                 330                 335     

Arg Gln Asn Ser Gln Lys Val Ile Phe His Ile Thr Asp Gly Val Pro 
            340                 345                 350         

Thr Met Ser Tyr Pro Ile Asn Phe Asn His Ala Thr Phe Ala Pro Ser 
        355                 360                 365             

Tyr Gln Asn Gln Leu Asn Ala Phe Phe Ser Lys Ser Pro Asn Lys Asp 
    370                 375                 380                 

Gly Ile Leu Leu Ser Asp Phe Ile Thr Gln Ala Thr Ser Gly Glu His 
385                 390                 395                 400 

Thr Ile Val Arg Gly Asp Gly Gln Ser Tyr Gln Met Phe Thr Asp Lys 
                405                 410                 415     

Thr Val Tyr Glu Lys Gly Ala Pro Ala Ala Phe Pro Val Lys Pro Glu 
            420                 425                 430         

Lys Tyr Ser Glu Met Lys Ala Ala Gly Tyr Ala Val Ile Gly Asp Pro 
        435                 440                 445             

Ile Asn Gly Gly Tyr Ile Trp Leu Asn Trp Arg Glu Ser Ile Leu Ala 
    450                 455                 460                 

Tyr Pro Phe Asn Ser Asn Thr Ala Lys Ile Thr Asn His Gly Asp Pro 
465                 470                 475                 480 

Thr Arg Trp Tyr Tyr Asn Gly Asn Ile Ala Pro Asp Gly Tyr Asp Val 
                485                 490                 495     

Phe Thr Val Gly Ile Gly Ile Asn Gly Asp Pro Gly Thr Asp Glu Ala 
            500                 505                 510         

Thr Ala Thr Ser Phe Met Gln Ser Ile Ser Ser Lys Pro Glu Asn Tyr 
        515                 520                 525             

Thr Asn Val Thr Asp Thr Thr Lys Ile Leu Glu Gln Leu Asn Arg Tyr 
    530                 535                 540                 

Phe His Thr Ile Val Thr Glu Lys Lys Ser Ile Glu Asn Gly Thr Ile 
545                 550                 555                 560 

Thr Asp Pro Met Gly Glu Leu Ile Asp Leu Gln Leu Gly Thr Asp Gly 
                565                 570                 575     

Arg Phe Asp Pro Ala Asp Tyr Thr Leu Thr Ala Asn Asp Gly Ser Arg 
            580                 585                 590         

Leu Glu Asn Gly Gln Ala Val Gly Gly Pro Gln Asn Asp Gly Gly Leu 
        595                 600                 605             

Leu Lys Asn Ala Lys Val Leu Tyr Asp Thr Thr Glu Lys Arg Ile Arg 
    610                 615                 620                 

Val Thr Gly Leu Tyr Leu Gly Thr Asp Glu Lys Val Thr Leu Thr Tyr 
625                 630                 635                 640 

Asn Val Arg Leu Asn Asp Glu Phe Val Ser Asn Lys Phe Tyr Asp Thr 
                645                 650                 655     

Asn Gly Arg Thr Thr Leu His Pro Lys Glu Val Glu Gln Asn Thr Val 
            660                 665                 670         

Arg Asp Phe Pro Ile Pro Lys Ile Arg Asp Val Arg Lys Tyr Pro Glu 
        675                 680                 685             

Ile Thr Ile Ser Lys Glu Lys Lys Leu Gly Asp Ile Glu Phe Ile Lys 
    690                 695                 700                 

Val Asn Lys Asn Asp Lys Lys Pro Leu Arg Gly Ala Val Phe Ser Leu 
705                 710                 715                 720 

Gln Lys Gln His Pro Asp Tyr Pro Asp Ile Tyr Gly Ala Ile Asp Gln 
                725                 730                 735     

Asn Gly Thr Tyr Gln Asn Val Arg Thr Gly Glu Asp Gly Lys Leu Thr 
            740                 745                 750         

Phe Lys Asn Leu Ser Asp Gly Lys Tyr Arg Leu Phe Glu Asn Ser Glu 
        755                 760                 765             

Pro Ala Gly Tyr Lys Pro Val Gln Asn Lys Pro Ile Val Ala Phe Gln 
    770                 775                 780                 

Ile Val Asn Gly Glu Val Arg Asp Val Thr Ser Ile Val Pro Gln Asp 
785                 790                 795                 800 

Ile Pro Ala Gly Tyr Glu Phe Thr Asn Asp Lys His Tyr Ile Thr Asn 
                805                 810                 815     

Glu Pro Ile Pro Pro Lys Arg Glu 
            820                 

<210>   193
<211>   1630
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Hybrid polypeptide

<400>   193
Met Ala Glu Thr Thr Asp Asp Lys Ile Ala Ala Gln Asp Asn Lys Ile 
1               5                   10                  15      

Ser Asn Leu Thr Ala Gln Gln Gln Glu Ala Gln Lys Gln Val Asp Gln 
            20                  25                  30          

Ile Gln Glu Gln Val Ser Ala Ile Gln Ala Glu Gln Ser Asn Leu Gln 
        35                  40                  45              

Ala Glu Asn Asp Arg Leu Gln Ala Glu Ser Lys Lys Leu Glu Gly Glu 
    50                  55                  60                  

Ile Thr Glu Leu Ser Lys Asn Ile Val Ser Arg Asn Gln Ser Leu Glu 
65                  70                  75                  80  

Lys Gln Ala Arg Ser Ala Gln Thr Asn Gly Ala Val Thr Ser Tyr Ile 
                85                  90                  95      

Asn Thr Ile Val Asn Ser Lys Ser Ile Thr Glu Ala Ile Ser Arg Val 
            100                 105                 110         

Ala Ala Met Ser Glu Ile Val Ser Ala Asn Asn Lys Met Leu Glu Gln 
        115                 120                 125             

Gln Lys Ala Asp Lys Lys Ala Ile Ser Glu Lys Gln Val Ala Asn Asn 
    130                 135                 140                 

Asp Ala Ile Asn Thr Val Ile Ala Asn Gln Gln Lys Leu Ala Asp Asp 
145                 150                 155                 160 

Ala Gln Ala Leu Thr Thr Lys Gln Ala Glu Leu Lys Ala Ala Glu Leu 
                165                 170                 175     

Ser Leu Ala Ala Glu Lys Ala Thr Ala Glu Gly Glu Lys Ala Ser Leu 
            180                 185                 190         

Leu Glu Gln Lys Ala Ala Ala Glu Ala Glu Ala Arg Ala Ala Ala Val 
        195                 200                 205             

Ala Glu Ala Ala Tyr Lys Glu Lys Arg Ala Ser Gln Gln Gln Ser Val 
    210                 215                 220                 

Leu Ala Ser Ala Asn Thr Asn Leu Thr Ala Gln Val Gln Ala Val Ser 
225                 230                 235                 240 

Glu Ser Ala Ala Ala Pro Val Arg Ala Lys Val Arg Pro Thr Tyr Ser 
                245                 250                 255     

Thr Asn Ala Ser Ser Tyr Pro Ile Gly Glu Cys Thr Trp Gly Val Lys 
            260                 265                 270         

Thr Leu Ala Pro Trp Ala Gly Asp Tyr Trp Gly Asn Gly Ala Gln Trp 
        275                 280                 285             

Ala Thr Ser Ala Ala Ala Ala Gly Phe Arg Thr Gly Ser Thr Pro Gln 
    290                 295                 300                 

Val Gly Ala Ile Ala Cys Trp Asn Asp Gly Gly Tyr Gly His Val Ala 
305                 310                 315                 320 

Val Val Thr Ala Val Glu Ser Thr Thr Arg Ile Gln Val Ser Glu Ser 
                325                 330                 335     

Asn Tyr Ala Gly Asn Arg Thr Ile Gly Asn His Arg Gly Trp Phe Asn 
            340                 345                 350         

Pro Thr Thr Thr Ser Glu Gly Phe Val Thr Tyr Ile Tyr Ala Asp Gly 
        355                 360                 365             

Ser Gly Ser Gly Gly Gly Gly Ala Asp Gly Val Thr Pro Thr Thr Thr 
    370                 375                 380                 

Glu Asn Gln Pro Thr Ile His Thr Val Ser Asp Ser Pro Gln Ser Ser 
385                 390                 395                 400 

Glu Asn Arg Thr Glu Glu Thr Pro Lys Ala Val Leu Gln Pro Glu Ala 
                405                 410                 415     

Pro Lys Thr Val Glu Thr Glu Thr Pro Ala Thr Asp Lys Val Ala Ser 
            420                 425                 430         

Leu Pro Lys Thr Glu Glu Lys Pro Gln Glu Glu Val Ser Ser Thr Pro 
        435                 440                 445             

Ser Asp Lys Ala Glu Val Val Thr Pro Thr Ser Ala Glu Lys Glu Thr 
    450                 455                 460                 

Ala Asn Lys Lys Ala Glu Glu Ala Ser Pro Lys Lys Glu Glu Ala Lys 
465                 470                 475                 480 

Glu Val Asp Ser Lys Glu Ser Asn Thr Asp Lys Thr Asp Lys Asp Lys 
                485                 490                 495     

Pro Ala Lys Lys Asp Glu Ala Lys Ala Glu Ala Asp Lys Pro Ala Thr 
            500                 505                 510         

Glu Ala Gly Lys Glu Arg Ala Ala Thr Val Asn Glu Lys Leu Ala Lys 
        515                 520                 525             

Lys Lys Ile Val Ser Ile Asp Ala Gly Arg Lys Tyr Phe Ser Pro Glu 
    530                 535                 540                 

Gln Leu Lys Glu Ile Ile Asp Lys Ala Lys His Tyr Gly Tyr Thr Asp 
545                 550                 555                 560 

Leu His Leu Leu Val Gly Asn Asp Gly Leu Arg Phe Met Leu Asp Asp 
                565                 570                 575     

Met Ser Ile Thr Ala Asn Gly Lys Thr Tyr Ala Ser Asp Asp Val Lys 
            580                 585                 590         

Arg Ala Ile Glu Lys Gly Thr Asn Asp Tyr Tyr Asn Asp Pro Asn Gly 
        595                 600                 605             

Asn His Leu Thr Glu Ser Gln Met Thr Asp Leu Ile Asn Tyr Ala Lys 
    610                 615                 620                 

Asp Lys Gly Ile Gly Leu Ile Pro Thr Val Asn Ser Pro Gly His Met 
625                 630                 635                 640 

Asp Ala Ile Leu Asn Ala Met Lys Glu Leu Gly Ile Gln Asn Pro Asn 
                645                 650                 655     

Phe Ser Tyr Phe Gly Lys Lys Ser Ala Arg Thr Val Asp Leu Asp Asn 
            660                 665                 670         

Glu Gln Ala Val Ala Phe Thr Lys Ala Leu Ile Asp Lys Tyr Ala Ala 
        675                 680                 685             

Tyr Phe Ala Lys Lys Thr Glu Ile Phe Asn Ile Gly Leu Asp Glu Tyr 
    690                 695                 700                 

Ala Asn Asp Ala Thr Asp Ala Lys Gly Trp Ser Val Leu Gln Ala Asp 
705                 710                 715                 720 

Lys Tyr Tyr Pro Asn Glu Gly Tyr Pro Val Lys Gly Tyr Glu Lys Phe 
                725                 730                 735     

Ile Ala Tyr Ala Asn Asp Leu Ala Arg Ile Val Lys Ser His Gly Leu 
            740                 745                 750         

Lys Pro Met Ala Phe Asn Asp Gly Ile Tyr Tyr Asn Ser Asp Thr Ser 
        755                 760                 765             

Phe Gly Ser Phe Asp Lys Asp Ile Ile Val Ser Met Trp Thr Gly Gly 
    770                 775                 780                 

Trp Gly Gly Tyr Asp Val Ala Ser Ser Lys Leu Leu Ala Glu Lys Gly 
785                 790                 795                 800 

His Gln Ile Leu Asn Thr Asn Asp Ala Trp Tyr Tyr Val Leu Gly Arg 
                805                 810                 815     

Asn Ala Asp Gly Gln Gly Trp Tyr Asn Leu Asp Gln Gly Leu Asn Gly 
            820                 825                 830         

Ile Lys Asn Thr Pro Ile Thr Ser Val Pro Lys Thr Glu Gly Ala Asp 
        835                 840                 845             

Ile Pro Ile Ile Gly Gly Met Val Ala Ala Trp Ala Asp Thr Pro Ser 
    850                 855                 860                 

Ala Arg Tyr Ser Pro Ser Arg Leu Phe Lys Leu Met Arg His Phe Ala 
865                 870                 875                 880 

Asn Ala Asn Ala Glu Tyr Phe Ala Ala Asp Tyr Glu Ser Ala Glu Gln 
                885                 890                 895     

Ala Leu Asn Glu Val Pro Lys Asp Leu Asn Arg Tyr Thr Ala Glu Ser 
            900                 905                 910         

Val Thr Ala Val Lys Glu Ala Glu Lys Ala Ile Arg Ser Leu Asp Ser 
        915                 920                 925             

Asn Leu Ser Arg Ala Gln Gln Asp Thr Ile Asp Gln Ala Ile Ala Lys 
    930                 935                 940                 

Leu Gln Glu Thr Val Asn Asn Leu Thr Leu Thr Pro Glu Ala Gln Lys 
945                 950                 955                 960 

Glu Glu Glu Ala Lys Arg Glu Val Glu Lys Leu Ala Lys Asn Lys Val 
                965                 970                 975     

Ile Ser Ile Asp Ala Gly Arg Lys Tyr Phe Thr Leu Asn Gln Leu Lys 
            980                 985                 990         

Arg Ile Val Asp Lys Ala Ser Glu Leu Gly Tyr Ser Asp Val His Leu 
        995                 1000                1005            

Leu Leu Gly Asn Asp Gly Leu Arg Phe Leu Leu Asp Asp Met Thr Ile 
    1010                1015                1020                

Thr Ala Asn Gly Lys Thr Tyr Ala Ser Asp Asp Val Lys Lys Ala Ile 
1025                1030                1035                1040

Ile Glu Gly Thr Lys Ala Tyr Tyr Asp Asp Pro Asn Gly Thr Ala Leu 
                1045                1050                1055    

Thr Gln Ala Glu Val Thr Glu Leu Ile Glu Tyr Ala Lys Ser Lys Asp 
            1060                1065                1070        

Ile Gly Leu Ile Pro Ala Ile Asn Ser Pro Gly His Met Asp Ala Met 
        1075                1080                1085            

Leu Val Ala Met Glu Lys Leu Gly Ile Lys Asn Pro Gln Ala His Phe 
    1090                1095                1100                

Asp Lys Val Ser Lys Thr Thr Met Asp Leu Lys Asn Glu Glu Ala Met 
1105                1110                1115                1120

Asn Phe Val Lys Ala Leu Ile Gly Lys Tyr Met Asp Phe Phe Ala Gly 
                1125                1130                1135    

Lys Thr Lys Ile Phe Asn Phe Gly Thr Asp Glu Tyr Ala Asn Asp Ala 
            1140                1145                1150        

Thr Ser Ala Gln Gly Trp Tyr Tyr Leu Lys Trp Tyr Gln Leu Tyr Gly 
        1155                1160                1165            

Lys Phe Ala Glu Tyr Ala Asn Thr Leu Ala Ala Met Ala Lys Glu Arg 
    1170                1175                1180                

Gly Leu Gln Pro Met Ala Phe Asn Asp Gly Phe Tyr Tyr Glu Asp Lys 
1185                1190                1195                1200

Asp Asp Val Gln Phe Asp Lys Asp Val Leu Ile Ser Tyr Trp Ser Lys 
                1205                1210                1215    

Gly Trp Trp Gly Tyr Asn Leu Ala Ser Pro Gln Tyr Leu Ala Ser Lys 
            1220                1225                1230        

Gly Tyr Lys Phe Leu Asn Thr Asn Gly Asp Trp Tyr Tyr Ile Leu Gly 
        1235                1240                1245            

Gln Lys Pro Glu Asp Gly Gly Gly Phe Leu Lys Lys Ala Ile Glu Asn 
    1250                1255                1260                

Thr Gly Lys Thr Pro Phe Asn Gln Leu Ala Ser Thr Lys Tyr Pro Glu 
1265                1270                1275                1280

Val Asp Leu Pro Thr Val Gly Ser Met Leu Ser Ile Trp Ala Asp Arg 
                1285                1290                1295    

Pro Ser Ala Glu Tyr Lys Glu Glu Glu Ile Phe Glu Leu Met Thr Ala 
            1300                1305                1310        

Phe Ala Asp His Asn Lys Asp Tyr Phe Arg Ala Asn Tyr Asn Ala Leu 
        1315                1320                1325            

Arg Glu Glu Leu Ala Lys Ile Pro Thr Asn Leu Glu Gly Tyr Ser Lys 
    1330                1335                1340                

Glu Ser Leu Glu Ala Leu Asp Ala Ala Lys Thr Ala Leu Asn Tyr Asn 
1345                1350                1355                1360

Leu Asn Arg Asn Lys Gln Ala Glu Leu Asp Thr Leu Val Ala Asn Leu 
                1365                1370                1375    

Lys Ala Ala Leu Gln Gly Leu Lys Pro Ala Val Thr His Ser Gly Ser 
            1380                1385                1390        

Leu Asp Glu Asn Glu Val Ala Ala Asn Val Glu Thr Arg Pro Glu Leu 
        1395                1400                1405            

Ile Thr Arg Thr Glu Glu Ile Pro Phe Glu Val Ile Lys Lys Glu Asn 
    1410                1415                1420                

Pro Asn Leu Pro Ala Gly Gln Glu Asn Ile Ile Thr Ala Gly Val Lys 
1425                1430                1435                1440

Gly Glu Arg Thr His Tyr Ile Ser Val Leu Thr Glu Asn Gly Lys Thr 
                1445                1450                1455    

Thr Glu Thr Val Leu Asp Ser Gln Val Thr Lys Glu Val Ile Asn Gln 
            1460                1465                1470        

Val Val Glu Val Gly Ala Pro Val Thr His Lys Gly Asp Glu Ser Gly 
        1475                1480                1485            

Leu Ala Pro Thr Thr Glu Val Lys Pro Arg Leu Asp Ile Gln Glu Glu 
    1490                1495                1500                

Glu Ile Pro Phe Thr Thr Val Thr Cys Glu Asn Pro Leu Leu Leu Lys 
1505                1510                1515                1520

Gly Lys Thr Gln Val Ile Thr Lys Gly Val Asn Gly His Arg Ser Asn 
                1525                1530                1535    

Phe Tyr Ser Val Ser Thr Ser Ala Asp Gly Lys Glu Val Lys Thr Leu 
            1540                1545                1550        

Val Asn Ser Val Val Ala Gln Glu Ala Val Thr Gln Ile Val Glu Val 
        1555                1560                1565            

Gly Thr Met Val Thr His Val Gly Asp Glu Asn Gly Gln Ala Ala Ile 
    1570                1575                1580                

Ala Glu Glu Lys Pro Lys Leu Glu Ile Pro Ser Gln Pro Ala Pro Ser 
1585                1590                1595                1600

Thr Ala Pro Ala Glu Glu Ser Lys Val Leu Pro Gln Asp Pro Ala Pro 
                1605                1610                1615    

Val Val Thr Glu Lys Lys Leu Glu His His His His His His 
            1620                1625                1630

<210>   194
<211>   552
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Hybrid polypeptide

<400>   194
Met Ala Glu Thr Thr Asp Asp Lys Ile Ala Ala Gln Asp Asn Lys Ile 
1               5                   10                  15      

Ser Asn Leu Thr Ala Gln Gln Gln Glu Ala Gln Lys Gln Val Asp Gln 
            20                  25                  30          

Ile Gln Glu Gln Val Ser Ala Ile Gln Ala Glu Gln Ser Asn Leu Gln 
        35                  40                  45              

Ala Glu Asn Asp Arg Leu Gln Ala Glu Ser Lys Lys Leu Glu Gly Glu 
    50                  55                  60                  

Ile Thr Glu Leu Ser Lys Asn Ile Val Ser Arg Asn Gln Ser Leu Glu 
65                  70                  75                  80  

Lys Gln Ala Arg Ser Ala Gln Thr Asn Gly Ala Val Thr Ser Tyr Ile 
                85                  90                  95      

Asn Thr Ile Val Asn Ser Lys Ser Ile Thr Glu Ala Ile Ser Arg Val 
            100                 105                 110         

Ala Ala Met Ser Glu Ile Val Ser Ala Asn Asn Lys Met Leu Glu Gln 
        115                 120                 125             

Gln Lys Ala Asp Lys Lys Ala Ile Ser Glu Lys Gln Val Ala Asn Asn 
    130                 135                 140                 

Asp Ala Ile Asn Thr Val Ile Ala Asn Gln Gln Lys Leu Ala Asp Asp 
145                 150                 155                 160 

Ala Gln Ala Leu Thr Thr Lys Gln Ala Glu Leu Lys Ala Ala Glu Leu 
                165                 170                 175     

Ser Leu Ala Ala Glu Lys Ala Thr Ala Glu Gly Glu Lys Ala Ser Leu 
            180                 185                 190         

Leu Glu Gln Lys Ala Ala Ala Glu Ala Glu Ala Arg Ala Ala Ala Val 
        195                 200                 205             

Ala Glu Ala Ala Tyr Lys Glu Lys Arg Ala Ser Gln Gln Gln Ser Val 
    210                 215                 220                 

Leu Ala Ser Ala Asn Thr Asn Leu Thr Ala Gln Val Gln Ala Val Ser 
225                 230                 235                 240 

Glu Ser Ala Ala Ala Pro Val Arg Ala Lys Val Arg Pro Thr Tyr Ser 
                245                 250                 255     

Thr Asn Ala Ser Ser Tyr Pro Ile Gly Glu Cys Thr Trp Gly Val Lys 
            260                 265                 270         

Thr Leu Ala Pro Trp Ala Gly Asp Tyr Trp Gly Asn Gly Ala Gln Trp 
        275                 280                 285             

Ala Thr Ser Ala Ala Ala Ala Gly Phe Arg Thr Gly Ser Thr Pro Gln 
    290                 295                 300                 

Val Gly Ala Ile Ala Cys Trp Asn Asp Gly Gly Tyr Gly His Val Ala 
305                 310                 315                 320 

Val Val Thr Ala Val Glu Ser Thr Thr Arg Ile Gln Val Ser Glu Ser 
                325                 330                 335     

Asn Tyr Ala Gly Asn Arg Thr Ile Gly Asn His Arg Gly Trp Phe Asn 
            340                 345                 350         

Pro Thr Thr Thr Ser Glu Gly Phe Val Thr Tyr Ile Tyr Ala Asp Gly 
        355                 360                 365             

Ser Gly Ser Gly Gly Gly Gly Val Ser Ala Gln Glu Ser Ser Thr Tyr 
    370                 375                 380                 

Thr Val Lys Glu Gly Asp Thr Leu Ser Glu Ile Ala Glu Thr His Asn 
385                 390                 395                 400 

Thr Thr Val Glu Lys Leu Ala Glu Asn Asn His Ile Asp Asn Ile His 
                405                 410                 415     

Leu Ile Tyr Val Asp Gln Glu Leu Val Ile Asp Gly Pro Val Ala Pro 
            420                 425                 430         

Val Ala Thr Pro Ala Pro Ala Thr Tyr Ala Ala Pro Ala Ala Gln Asp 
        435                 440                 445             

Glu Thr Val Ser Ala Pro Val Ala Glu Thr Pro Val Val Ser Glu Thr 
    450                 455                 460                 

Val Val Ser Thr Val Ser Gly Ser Glu Ala Glu Ala Lys Glu Trp Ile 
465                 470                 475                 480 

Ala Gln Lys Glu Ser Gly Gly Ser Tyr Thr Ala Thr Asn Gly Arg Tyr 
                485                 490                 495     

Ile Gly Arg Tyr Gln Leu Thr Asp Ser Tyr Leu Asn Gly Asp Tyr Ser 
            500                 505                 510         

Ala Glu Asn Gln Glu Arg Val Ala Asp Ala Tyr Val Ala Gly Arg Tyr 
        515                 520                 525             

Gly Ser Trp Thr Ala Ala Lys Asn Phe Trp Leu Asn Asn Gly Trp Tyr 
    530                 535                 540                 

Leu Glu His His His His His His 
545                 550         

<210>   195
<211>   2539
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Hybrid polypeptide

<400>   195
Met Ala Glu Thr Thr Asp Asp Lys Ile Ala Ala Gln Asp Asn Lys Ile 
1               5                   10                  15      

Ser Asn Leu Thr Ala Gln Gln Gln Glu Ala Gln Lys Gln Val Asp Gln 
            20                  25                  30          

Ile Gln Glu Gln Val Ser Ala Ile Gln Ala Glu Gln Ser Asn Leu Gln 
        35                  40                  45              

Ala Glu Asn Asp Arg Leu Gln Ala Glu Ser Lys Lys Leu Glu Gly Glu 
    50                  55                  60                  

Ile Thr Glu Leu Ser Lys Asn Ile Val Ser Arg Asn Gln Ser Leu Glu 
65                  70                  75                  80  

Lys Gln Ala Arg Ser Ala Gln Thr Asn Gly Ala Val Thr Ser Tyr Ile 
                85                  90                  95      

Asn Thr Ile Val Asn Ser Lys Ser Ile Thr Glu Ala Ile Ser Arg Val 
            100                 105                 110         

Ala Ala Met Ser Glu Ile Val Ser Ala Asn Asn Lys Met Leu Glu Gln 
        115                 120                 125             

Gln Lys Ala Asp Lys Lys Ala Ile Ser Glu Lys Gln Val Ala Asn Asn 
    130                 135                 140                 

Asp Ala Ile Asn Thr Val Ile Ala Asn Gln Gln Lys Leu Ala Asp Asp 
145                 150                 155                 160 

Ala Gln Ala Leu Thr Thr Lys Gln Ala Glu Leu Lys Ala Ala Glu Leu 
                165                 170                 175     

Ser Leu Ala Ala Glu Lys Ala Thr Ala Glu Gly Glu Lys Ala Ser Leu 
            180                 185                 190         

Leu Glu Gln Lys Ala Ala Ala Glu Ala Glu Ala Arg Ala Ala Ala Val 
        195                 200                 205             

Ala Glu Ala Ala Tyr Lys Glu Lys Arg Ala Ser Gln Gln Gln Ser Val 
    210                 215                 220                 

Leu Ala Ser Ala Asn Thr Asn Leu Thr Ala Gln Val Gln Ala Val Ser 
225                 230                 235                 240 

Glu Ser Ala Ala Ala Pro Val Arg Ala Lys Val Arg Pro Thr Tyr Ser 
                245                 250                 255     

Thr Asn Ala Ser Ser Tyr Pro Ile Gly Glu Cys Thr Trp Gly Val Lys 
            260                 265                 270         

Thr Leu Ala Pro Trp Ala Gly Asp Tyr Trp Gly Asn Gly Ala Gln Trp 
        275                 280                 285             

Ala Thr Ser Ala Ala Ala Ala Gly Phe Arg Thr Gly Ser Thr Pro Gln 
    290                 295                 300                 

Val Gly Ala Ile Ala Cys Trp Asn Asp Gly Gly Tyr Gly His Val Ala 
305                 310                 315                 320 

Val Val Thr Ala Val Glu Ser Thr Thr Arg Ile Gln Val Ser Glu Ser 
                325                 330                 335     

Asn Tyr Ala Gly Asn Arg Thr Ile Gly Asn His Arg Gly Trp Phe Asn 
            340                 345                 350         

Pro Thr Thr Thr Ser Glu Gly Phe Val Thr Tyr Ile Tyr Ala Asp Gly 
        355                 360                 365             

Ser Gly Ser Gly Gly Gly Gly Asp Glu Thr Leu Ile Thr His Thr Ala 
    370                 375                 380                 

Glu Lys Pro Lys Glu Glu Lys Met Ile Val Glu Glu Lys Ala Asp Lys 
385                 390                 395                 400 

Ala Leu Glu Thr Lys Asn Ile Val Glu Arg Thr Glu Gln Ser Glu Pro 
                405                 410                 415     

Ser Ser Thr Glu Ala Ile Ala Ser Glu Lys Lys Glu Asp Glu Ala Val 
            420                 425                 430         

Thr Pro Lys Glu Glu Lys Val Ser Ala Lys Pro Glu Glu Lys Ala Pro 
        435                 440                 445             

Arg Ile Glu Ser Gln Ala Ser Asn Gln Glu Lys Pro Leu Lys Glu Asp 
    450                 455                 460                 

Ala Lys Ala Val Thr Asn Glu Glu Val Asn Gln Met Ile Glu Asp Arg 
465                 470                 475                 480 

Lys Val Asp Phe Asn Gln Asn Trp Tyr Phe Lys Leu Asn Ala Asn Ser 
                485                 490                 495     

Lys Glu Ala Ile Lys Pro Asp Ala Asp Val Ser Thr Trp Lys Lys Leu 
            500                 505                 510         

Asp Leu Pro Tyr Asp Trp Ser Ile Phe Asn Asp Phe Asp His Glu Ser 
        515                 520                 525             

Pro Ala Gln Asn Glu Gly Gly Gln Leu Asn Gly Gly Glu Ala Trp Tyr 
    530                 535                 540                 

Arg Lys Thr Phe Lys Leu Asp Glu Lys Asp Leu Lys Lys Asn Val Arg 
545                 550                 555                 560 

Leu Thr Phe Asp Gly Val Tyr Met Asp Ser Gln Val Tyr Val Asn Gly 
                565                 570                 575     

Gln Leu Val Gly His Tyr Pro Asn Gly Tyr Asn Gln Phe Ser Tyr Asp 
            580                 585                 590         

Ile Thr Lys Tyr Leu Gln Lys Asp Gly Arg Glu Asn Val Ile Ala Val 
        595                 600                 605             

His Ala Val Asn Lys Gln Pro Ser Ser Arg Trp Tyr Ser Gly Ser Gly 
    610                 615                 620                 

Ile Tyr Arg Asp Val Thr Leu Gln Val Thr Asp Lys Val His Val Glu 
625                 630                 635                 640 

Lys Asn Gly Thr Thr Ile Leu Thr Pro Lys Leu Glu Glu Gln Gln His 
                645                 650                 655     

Gly Lys Val Glu Thr His Val Thr Ser Lys Ile Val Asn Thr Asp Asp 
            660                 665                 670         

Lys Asp His Glu Leu Val Ala Glu Tyr Gln Ile Val Glu Arg Gly Gly 
        675                 680                 685             

His Ala Val Thr Gly Leu Val Arg Thr Ala Ser Arg Thr Leu Lys Ala 
    690                 695                 700                 

His Glu Ser Thr Ser Leu Asp Ala Ile Leu Glu Val Glu Arg Pro Lys 
705                 710                 715                 720 

Leu Trp Thr Val Leu Asn Asp Lys Pro Ala Leu Tyr Glu Leu Ile Thr 
                725                 730                 735     

Arg Val Tyr Arg Asp Gly Gln Leu Val Asp Ala Lys Lys Asp Leu Phe 
            740                 745                 750         

Gly Tyr Arg Tyr Tyr His Trp Thr Pro Asn Glu Gly Phe Ser Leu Asn 
        755                 760                 765             

Gly Glu Arg Ile Lys Phe His Gly Val Ser Leu His His Asp His Gly 
    770                 775                 780                 

Ala Leu Gly Ala Glu Glu Asn Tyr Lys Ala Glu Tyr Arg Arg Leu Lys 
785                 790                 795                 800 

Gln Met Lys Glu Met Gly Val Asn Ser Ile Arg Thr Thr His Asn Pro 
                805                 810                 815     

Ala Ser Glu Gln Thr Leu Gln Ile Ala Ala Glu Leu Gly Leu Leu Val 
            820                 825                 830         

Gln Glu Glu Ala Phe Asp Thr Trp Tyr Gly Gly Lys Lys Pro Tyr Asp 
        835                 840                 845             

Tyr Gly Arg Phe Phe Glu Lys Asp Ala Thr His Pro Glu Ala Arg Lys 
    850                 855                 860                 

Gly Glu Lys Trp Ser Asp Phe Asp Leu Arg Thr Met Val Glu Arg Gly 
865                 870                 875                 880 

Lys Asn Asn Pro Ala Ile Phe Met Trp Ser Ile Gly Asn Glu Ile Gly 
                885                 890                 895     

Glu Ala Asn Gly Asp Ala His Ser Leu Ala Thr Val Lys Arg Leu Val 
            900                 905                 910         

Lys Val Ile Lys Asp Val Asp Lys Thr Arg Tyr Val Thr Met Gly Ala 
        915                 920                 925             

Asp Lys Phe Arg Phe Gly Asn Gly Ser Gly Gly His Glu Lys Ile Ala 
    930                 935                 940                 

Asp Glu Leu Asp Ala Val Gly Phe Asn Tyr Ser Glu Asp Asn Tyr Lys 
945                 950                 955                 960 

Ala Leu Arg Ala Lys His Pro Lys Trp Leu Ile Tyr Gly Ser Glu Thr 
                965                 970                 975     

Ser Ser Ala Thr Arg Thr Arg Gly Ser Tyr Tyr Arg Pro Glu Arg Glu 
            980                 985                 990         

Leu Lys His Ser Asn Gly Pro Glu Arg Asn Tyr Glu Gln Ser Asp Tyr 
        995                 1000                1005            

Gly Asn Asp Arg Val Gly Trp Gly Lys Thr Ala Thr Ala Ser Trp Thr 
    1010                1015                1020                

Phe Asp Arg Asp Asn Ala Gly Tyr Ala Gly Gln Phe Ile Trp Thr Gly 
1025                1030                1035                1040

Thr Asp Tyr Ile Gly Glu Pro Thr Pro Trp His Asn Gln Asn Gln Thr 
                1045                1050                1055    

Pro Val Lys Ser Ser Tyr Phe Gly Ile Val Asp Thr Ala Gly Ile Pro 
            1060                1065                1070        

Lys His Asp Phe Tyr Leu Tyr Gln Ser Gln Trp Val Ser Val Lys Lys 
        1075                1080                1085            

Lys Pro Met Val His Leu Leu Pro His Trp Asn Trp Glu Asn Lys Glu 
    1090                1095                1100                

Leu Ala Ser Lys Val Ala Asp Ser Glu Gly Lys Ile Pro Val Arg Ala 
1105                1110                1115                1120

Tyr Ser Asn Ala Ser Ser Val Glu Leu Phe Leu Asn Gly Lys Ser Leu 
                1125                1130                1135    

Gly Leu Lys Thr Phe Asn Lys Lys Gln Thr Ser Asp Gly Arg Thr Tyr 
            1140                1145                1150        

Gln Glu Gly Ala Asn Ala Asn Glu Leu Tyr Leu Glu Trp Lys Val Ala 
        1155                1160                1165            

Tyr Gln Pro Gly Thr Leu Glu Ala Ile Ala Arg Asp Glu Ser Gly Lys 
    1170                1175                1180                

Glu Ile Ala Arg Asp Lys Ile Thr Thr Ala Gly Lys Pro Ala Ala Val 
1185                1190                1195                1200

Arg Leu Ile Lys Glu Asp His Ala Ile Ala Ala Asp Gly Lys Asp Leu 
                1205                1210                1215    

Thr Tyr Ile Tyr Tyr Glu Ile Val Asp Ser Gln Gly Asn Val Val Pro 
            1220                1225                1230        

Thr Ala Asn Asn Leu Val Arg Phe Gln Leu His Gly Gln Gly Gln Leu 
        1235                1240                1245            

Val Gly Val Asp Asn Gly Glu Gln Ala Ser Arg Glu Arg Tyr Lys Ala 
    1250                1255                1260                

Gln Ala Asp Gly Ser Trp Ile Arg Lys Ala Phe Asn Gly Lys Gly Val 
1265                1270                1275                1280

Ala Ile Val Lys Ser Thr Glu Gln Ala Gly Lys Phe Thr Leu Thr Ala 
                1285                1290                1295    

His Ser Asp Leu Leu Lys Ser Asn Gln Val Thr Val Phe Thr Gly Lys 
            1300                1305                1310        

Lys Glu Gly Gln Glu Lys Thr Val Leu Gly Thr Glu Val Pro Lys Val 
        1315                1320                1325            

Gln Thr Ile Ile Gly Glu Ala Pro Glu Met Pro Thr Thr Val Pro Phe 
    1330                1335                1340                

Val Tyr Ser Asp Gly Ser Arg Ala Glu Arg Pro Val Thr Trp Ser Ser 
1345                1350                1355                1360

Val Asp Val Ser Lys Pro Gly Ile Val Thr Val Lys Gly Met Ala Asp 
                1365                1370                1375    

Gly Arg Glu Val Glu Ala Arg Val Glu Val Ile Ala Leu Lys Ser Glu 
            1380                1385                1390        

Leu Pro Val Val Lys Arg Ile Ala Pro Asn Thr Asp Leu Asn Ser Val 
        1395                1400                1405            

Asp Lys Ser Val Ser Tyr Val Leu Ile Asp Gly Ser Val Glu Glu Tyr 
    1410                1415                1420                

Glu Val Asp Lys Trp Glu Ile Ala Glu Glu Asp Lys Ala Lys Leu Ala 
1425                1430                1435                1440

Ile Pro Gly Ser Arg Ile Gln Ala Thr Gly Tyr Leu Glu Gly Gln Pro 
                1445                1450                1455    

Ile His Ala Thr Leu Val Val Glu Glu Gly Asn Pro Ala Ala Pro Ala 
            1460                1465                1470        

Val Pro Thr Val Thr Val Gly Gly Glu Ala Val Thr Gly Leu Thr Ser 
        1475                1480                1485            

Gln Lys Pro Met Gln Tyr Arg Thr Leu Ala Tyr Gly Ala Lys Leu Pro 
    1490                1495                1500                

Glu Val Thr Ala Ser Ala Lys Asn Ala Ala Val Thr Val Leu Gln Ala 
1505                1510                1515                1520

Ser Ala Ala Asn Gly Met Arg Ala Ser Ile Phe Ile Gln Pro Lys Asp 
                1525                1530                1535    

Gly Gly Pro Leu Gln Thr Tyr Ala Ile Gln Phe Leu Glu Glu Ala Pro 
            1540                1545                1550        

Lys Ile Ala His Leu Ser Leu Gln Val Glu Lys Ala Asp Ser Leu Lys 
        1555                1560                1565            

Glu Asp Gln Thr Val Lys Leu Ser Val Arg Ala His Tyr Gln Asp Gly 
    1570                1575                1580                

Thr Gln Ala Val Leu Pro Ala Asp Lys Val Thr Phe Ser Thr Ser Gly 
1585                1590                1595                1600

Glu Gly Glu Val Ala Ile Arg Lys Gly Met Leu Glu Leu His Lys Pro 
                1605                1610                1615    

Gly Ala Val Thr Leu Asn Ala Glu Tyr Glu Gly Ala Lys Asp Gln Val 
            1620                1625                1630        

Glu Leu Thr Ile Gln Ala Asn Thr Glu Lys Lys Ile Ala Gln Ser Ile 
        1635                1640                1645            

Arg Pro Val Asn Val Val Thr Asp Leu His Gln Glu Pro Ser Leu Pro 
    1650                1655                1660                

Ala Thr Val Thr Val Glu Tyr Asp Lys Gly Phe Pro Lys Thr His Lys 
1665                1670                1675                1680

Val Thr Trp Gln Ala Ile Pro Lys Glu Lys Leu Asp Ser Tyr Gln Thr 
                1685                1690                1695    

Phe Glu Val Leu Gly Lys Val Glu Gly Ile Asp Leu Glu Ala Arg Ala 
            1700                1705                1710        

Lys Val Ser Val Glu Gly Ile Val Ser Val Glu Glu Val Ser Val Thr 
        1715                1720                1725            

Thr Pro Ile Ala Glu Ala Pro Gln Leu Pro Glu Ser Val Arg Thr Tyr 
    1730                1735                1740                

Asp Ser Asn Gly His Val Ser Ser Ala Lys Val Ala Trp Asp Ala Ile 
1745                1750                1755                1760

Arg Pro Glu Gln Tyr Ala Lys Glu Gly Val Phe Thr Val Asn Gly Arg 
                1765                1770                1775    

Leu Glu Gly Thr Gln Leu Thr Thr Lys Leu His Val Arg Val Ser Ala 
            1780                1785                1790        

Gln Thr Glu Gln Gly Ala Asn Ile Ser Asp Gln Trp Thr Gly Ser Glu 
        1795                1800                1805            

Leu Pro Leu Ala Phe Ala Ser Asp Ser Asn Pro Ser Asp Pro Val Ser 
    1810                1815                1820                

Asn Val Asn Asp Lys Leu Ile Ser Tyr Asn Asn Gln Pro Ala Asn Arg 
1825                1830                1835                1840

Trp Thr Asn Trp Asn Arg Thr Asn Pro Glu Ala Ser Val Gly Val Leu 
                1845                1850                1855    

Phe Gly Asp Ser Gly Ile Leu Ser Lys Arg Ser Val Asp Asn Leu Ser 
            1860                1865                1870        

Val Gly Phe His Glu Asp His Gly Val Gly Val Pro Lys Ser Tyr Val 
        1875                1880                1885            

Ile Glu Tyr Tyr Val Gly Lys Thr Val Pro Thr Ala Pro Lys Asn Pro 
    1890                1895                1900                

Ser Phe Val Gly Asn Glu Asp His Val Phe Asn Asp Ser Ala Asn Trp 
1905                1910                1915                1920

Lys Pro Val Thr Asn Leu Lys Ala Pro Ala Gln Leu Lys Ala Gly Glu 
                1925                1930                1935    

Met Asn His Phe Ser Phe Asp Lys Val Glu Thr Tyr Ala Val Arg Ile 
            1940                1945                1950        

Arg Met Val Lys Ala Asp Asn Lys Arg Gly Thr Ser Ile Thr Glu Val 
        1955                1960                1965            

Gln Ile Phe Ala Lys Gln Val Ala Ala Ala Lys Gln Gly Gln Thr Arg 
    1970                1975                1980                

Ile Gln Val Asp Gly Lys Asp Leu Ala Asn Phe Asn Pro Asp Leu Thr 
1985                1990                1995                2000

Asp Tyr Tyr Leu Glu Ser Val Asp Gly Lys Val Pro Ala Val Thr Ala 
                2005                2010                2015    

Ser Val Ser Asn Asn Gly Leu Ala Thr Val Val Pro Ser Val Arg Glu 
            2020                2025                2030        

Gly Glu Pro Val Arg Val Ile Ala Lys Ala Glu Asn Gly Asp Ile Leu 
        2035                2040                2045            

Gly Glu Tyr Arg Leu His Phe Thr Lys Asp Lys Ser Leu Leu Ser His 
    2050                2055                2060                

Lys Pro Val Ala Ala Val Lys Gln Ala Arg Leu Leu Gln Val Gly Gln 
2065                2070                2075                2080

Ala Leu Glu Leu Pro Thr Lys Val Pro Val Tyr Phe Thr Gly Lys Asp 
                2085                2090                2095    

Gly Tyr Glu Thr Lys Asp Leu Thr Val Glu Trp Glu Glu Val Pro Ala 
            2100                2105                2110        

Glu Asn Leu Thr Lys Ala Gly Gln Phe Thr Val Arg Gly Arg Val Leu 
        2115                2120                2125            

Gly Ser Asn Leu Val Ala Glu Ile Thr Val Arg Val Thr Asp Lys Leu 
    2130                2135                2140                

Gly Glu Thr Leu Ser Asp Asn Pro Asn Tyr Asp Glu Asn Ser Asn Gln 
2145                2150                2155                2160

Ala Phe Ala Ser Ala Thr Asn Asp Ile Asp Lys Asn Ser His Asp Arg 
                2165                2170                2175    

Val Asp Tyr Leu Asn Asp Gly Asp His Ser Glu Asn Arg Arg Trp Thr 
            2180                2185                2190        

Asn Trp Ser Pro Thr Pro Ser Ser Asn Pro Glu Val Ser Ala Gly Val 
        2195                2200                2205            

Ile Phe Arg Glu Asn Gly Lys Ile Val Glu Arg Thr Val Thr Gln Gly 
    2210                2215                2220                

Lys Val Gln Phe Phe Ala Asp Ser Gly Thr Asp Ala Pro Ser Lys Leu 
2225                2230                2235                2240

Val Leu Glu Arg Tyr Val Gly Pro Glu Phe Glu Val Pro Thr Tyr Tyr 
                2245                2250                2255    

Ser Asn Tyr Gln Ala Tyr Asp Ala Asp His Pro Phe Asn Asn Pro Glu 
            2260                2265                2270        

Asn Trp Glu Ala Val Pro Tyr Arg Ala Asp Lys Asp Ile Ala Ala Gly 
        2275                2280                2285            

Asp Glu Ile Asn Val Thr Phe Lys Ala Ile Lys Ala Lys Ala Met Arg 
    2290                2295                2300                

Trp Arg Met Glu Arg Lys Ala Asp Lys Ser Gly Val Ala Met Ile Glu 
2305                2310                2315                2320

Met Thr Phe Leu Ala Pro Ser Glu Leu Pro Gln Glu Ser Thr Gln Ser 
                2325                2330                2335    

Lys Ile Leu Val Asp Gly Lys Glu Leu Ala Asp Phe Ala Glu Asn Arg 
            2340                2345                2350        

Gln Asp Tyr Gln Ile Thr Tyr Lys Gly Gln Arg Pro Lys Val Ser Val 
        2355                2360                2365            

Glu Glu Asn Asn Gln Val Ala Ser Thr Val Val Asp Ser Gly Glu Asp 
    2370                2375                2380                

Ser Phe Pro Val Leu Val Arg Leu Val Ser Glu Ser Gly Lys Gln Val 
2385                2390                2395                2400

Lys Glu Tyr Arg Ile His Leu Thr Lys Glu Lys Pro Val Ser Glu Lys 
                2405                2410                2415    

Thr Val Ala Ala Val Gln Glu Asp Leu Pro Lys Ile Glu Phe Val Glu 
            2420                2425                2430        

Lys Asp Leu Ala Tyr Lys Thr Val Glu Lys Lys Asp Ser Thr Leu Tyr 
        2435                2440                2445            

Leu Gly Glu Thr Arg Val Glu Gln Glu Gly Lys Val Gly Lys Glu Arg 
    2450                2455                2460                

Ile Phe Thr Ala Ile Asn Pro Asp Gly Ser Lys Glu Glu Lys Leu Arg 
2465                2470                2475                2480

Glu Val Val Glu Val Pro Thr Asp Arg Ile Val Leu Val Gly Thr Lys 
                2485                2490                2495    

Pro Val Ala Gln Glu Ala Lys Lys Pro Gln Val Ser Glu Lys Ala Asp 
            2500                2505                2510        

Thr Lys Pro Ile Asp Ser Ser Glu Ala Ser Gln Thr Asn Lys Ala Gln 
        2515                2520                2525            

Ala Ala Ala Leu Glu His His His His His His 
    2530                2535                

<210>   196
<211>   1449
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Hybrid polypeptide

<400>   196
Met Ala Glu Thr Thr Asp Asp Lys Ile Ala Ala Gln Asp Asn Lys Ile 
1               5                   10                  15      

Ser Asn Leu Thr Ala Gln Gln Gln Glu Ala Gln Lys Gln Val Asp Gln 
            20                  25                  30          

Ile Gln Glu Gln Val Ser Ala Ile Gln Ala Glu Gln Ser Asn Leu Gln 
        35                  40                  45              

Ala Glu Asn Asp Arg Leu Gln Ala Glu Ser Lys Lys Leu Glu Gly Glu 
    50                  55                  60                  

Ile Thr Glu Leu Ser Lys Asn Ile Val Ser Arg Asn Gln Ser Leu Glu 
65                  70                  75                  80  

Lys Gln Ala Arg Ser Ala Gln Thr Asn Gly Ala Val Thr Ser Tyr Ile 
                85                  90                  95      

Asn Thr Ile Val Asn Ser Lys Ser Ile Thr Glu Ala Ile Ser Arg Val 
            100                 105                 110         

Ala Ala Met Ser Glu Ile Val Ser Ala Asn Asn Lys Met Leu Glu Gln 
        115                 120                 125             

Gln Lys Ala Asp Lys Lys Ala Ile Ser Glu Lys Gln Val Ala Asn Asn 
    130                 135                 140                 

Asp Ala Ile Asn Thr Val Ile Ala Asn Gln Gln Lys Leu Ala Asp Asp 
145                 150                 155                 160 

Ala Gln Ala Leu Thr Thr Lys Gln Ala Glu Leu Lys Ala Ala Glu Leu 
                165                 170                 175     

Ser Leu Ala Ala Glu Lys Ala Thr Ala Glu Gly Glu Lys Ala Ser Leu 
            180                 185                 190         

Leu Glu Gln Lys Ala Ala Ala Glu Ala Glu Ala Arg Ala Ala Ala Val 
        195                 200                 205             

Ala Glu Ala Ala Tyr Lys Glu Lys Arg Ala Ser Gln Gln Gln Ser Val 
    210                 215                 220                 

Leu Ala Ser Ala Asn Thr Asn Leu Thr Ala Gln Val Gln Ala Val Ser 
225                 230                 235                 240 

Glu Ser Ala Ala Ala Pro Val Arg Ala Lys Val Arg Pro Thr Tyr Ser 
                245                 250                 255     

Thr Asn Ala Ser Ser Tyr Pro Ile Gly Glu Cys Thr Trp Gly Val Lys 
            260                 265                 270         

Thr Leu Ala Pro Trp Ala Gly Asp Tyr Trp Gly Asn Gly Ala Gln Trp 
        275                 280                 285             

Ala Thr Ser Ala Ala Ala Ala Gly Phe Arg Thr Gly Ser Thr Pro Gln 
    290                 295                 300                 

Val Gly Ala Ile Ala Cys Trp Asn Asp Gly Gly Tyr Gly His Val Ala 
305                 310                 315                 320 

Val Val Thr Ala Val Glu Ser Thr Thr Arg Ile Gln Val Ser Glu Ser 
                325                 330                 335     

Asn Tyr Ala Gly Asn Arg Thr Ile Gly Asn His Arg Gly Trp Phe Asn 
            340                 345                 350         

Pro Thr Thr Thr Ser Glu Gly Phe Val Thr Tyr Ile Tyr Ala Asp Gly 
        355                 360                 365             

Ser Gly Ser Gly Gly Gly Gly Asp Glu Thr Leu Ile Thr His Thr Ala 
    370                 375                 380                 

Glu Lys Pro Lys Glu Glu Lys Met Ile Val Glu Glu Lys Ala Asp Lys 
385                 390                 395                 400 

Ala Leu Glu Thr Lys Asn Ile Val Glu Arg Thr Glu Gln Ser Glu Pro 
                405                 410                 415     

Ser Ser Thr Glu Ala Ile Ala Ser Glu Lys Lys Glu Asp Glu Ala Val 
            420                 425                 430         

Thr Pro Lys Glu Glu Lys Val Ser Ala Lys Pro Glu Glu Lys Ala Pro 
        435                 440                 445             

Arg Ile Glu Ser Gln Ala Ser Asn Gln Glu Lys Pro Leu Lys Glu Asp 
    450                 455                 460                 

Ala Lys Ala Val Thr Asn Glu Glu Val Asn Gln Met Ile Glu Asp Arg 
465                 470                 475                 480 

Lys Val Asp Phe Asn Gln Asn Trp Tyr Phe Lys Leu Asn Ala Asn Ser 
                485                 490                 495     

Lys Glu Ala Ile Lys Pro Asp Ala Asp Val Ser Thr Trp Lys Lys Leu 
            500                 505                 510         

Asp Leu Pro Tyr Asp Trp Ser Ile Phe Asn Asp Phe Asp His Glu Ser 
        515                 520                 525             

Pro Ala Gln Asn Glu Gly Gly Gln Leu Asn Gly Gly Glu Ala Trp Tyr 
    530                 535                 540                 

Arg Lys Thr Phe Lys Leu Asp Glu Lys Asp Leu Lys Lys Asn Val Arg 
545                 550                 555                 560 

Leu Thr Phe Asp Gly Val Tyr Met Asp Ser Gln Val Tyr Val Asn Gly 
                565                 570                 575     

Gln Leu Val Gly His Tyr Pro Asn Gly Tyr Asn Gln Phe Ser Tyr Asp 
            580                 585                 590         

Ile Thr Lys Tyr Leu Gln Lys Asp Gly Arg Glu Asn Val Ile Ala Val 
        595                 600                 605             

His Ala Val Asn Lys Gln Pro Ser Ser Arg Trp Tyr Ser Gly Ser Gly 
    610                 615                 620                 

Ile Tyr Arg Asp Val Thr Leu Gln Val Thr Asp Lys Val His Val Glu 
625                 630                 635                 640 

Lys Asn Gly Thr Thr Ile Leu Thr Pro Lys Leu Glu Glu Gln Gln His 
                645                 650                 655     

Gly Lys Val Glu Thr His Val Thr Ser Lys Ile Val Asn Thr Asp Asp 
            660                 665                 670         

Lys Asp His Glu Leu Val Ala Glu Tyr Gln Ile Val Glu Arg Gly Gly 
        675                 680                 685             

His Ala Val Thr Gly Leu Val Arg Thr Ala Ser Arg Thr Leu Lys Ala 
    690                 695                 700                 

His Glu Ser Thr Ser Leu Asp Ala Ile Leu Glu Val Glu Arg Pro Lys 
705                 710                 715                 720 

Leu Trp Thr Val Leu Asn Asp Lys Pro Ala Leu Tyr Glu Leu Ile Thr 
                725                 730                 735     

Arg Val Tyr Arg Asp Gly Gln Leu Val Asp Ala Lys Lys Asp Leu Phe 
            740                 745                 750         

Gly Tyr Arg Tyr Tyr His Trp Thr Pro Asn Glu Gly Phe Ser Leu Asn 
        755                 760                 765             

Gly Glu Arg Ile Lys Phe His Gly Val Ser Leu His His Asp His Gly 
    770                 775                 780                 

Ala Leu Gly Ala Glu Glu Asn Tyr Lys Ala Glu Tyr Arg Arg Leu Lys 
785                 790                 795                 800 

Gln Met Lys Glu Met Gly Val Asn Ser Ile Arg Thr Thr His Asn Pro 
                805                 810                 815     

Ala Ser Glu Gln Thr Leu Gln Ile Ala Ala Glu Leu Gly Leu Leu Val 
            820                 825                 830         

Gln Glu Glu Ala Phe Asp Thr Trp Tyr Gly Gly Lys Lys Pro Tyr Asp 
        835                 840                 845             

Tyr Gly Arg Phe Phe Glu Lys Asp Ala Thr His Pro Glu Ala Arg Lys 
    850                 855                 860                 

Gly Glu Lys Trp Ser Asp Phe Asp Leu Arg Thr Met Val Glu Arg Gly 
865                 870                 875                 880 

Lys Asn Asn Pro Ala Ile Phe Met Trp Ser Ile Gly Asn Glu Ile Gly 
                885                 890                 895     

Glu Ala Asn Gly Asp Ala His Ser Leu Ala Thr Val Lys Arg Leu Val 
            900                 905                 910         

Lys Val Ile Lys Asp Val Asp Lys Thr Arg Tyr Val Thr Met Gly Ala 
        915                 920                 925             

Asp Lys Phe Arg Phe Gly Asn Gly Ser Gly Gly His Glu Lys Ile Ala 
    930                 935                 940                 

Asp Glu Leu Asp Ala Val Gly Phe Asn Tyr Ser Glu Asp Asn Tyr Lys 
945                 950                 955                 960 

Ala Leu Arg Ala Lys His Pro Lys Trp Leu Ile Tyr Gly Ser Glu Thr 
                965                 970                 975     

Ser Ser Ala Thr Arg Thr Arg Gly Ser Tyr Tyr Arg Pro Glu Arg Glu 
            980                 985                 990         

Leu Lys His Ser Asn Gly Pro Glu Arg Asn Tyr Glu Gln Ser Asp Tyr 
        995                 1000                1005            

Gly Asn Asp Arg Val Gly Trp Gly Lys Thr Ala Thr Ala Ser Trp Thr 
    1010                1015                1020                

Phe Asp Arg Asp Asn Ala Gly Tyr Ala Gly Gln Phe Ile Trp Thr Gly 
1025                1030                1035                1040

Thr Asp Tyr Ile Gly Glu Pro Thr Pro Trp His Asn Gln Asn Gln Thr 
                1045                1050                1055    

Pro Val Lys Ser Ser Tyr Phe Gly Ile Val Asp Thr Ala Gly Ile Pro 
            1060                1065                1070        

Lys His Asp Phe Tyr Leu Tyr Gln Ser Gln Trp Val Ser Val Lys Lys 
        1075                1080                1085            

Lys Pro Met Val His Leu Leu Pro His Trp Asn Trp Glu Asn Lys Glu 
    1090                1095                1100                

Leu Ala Ser Lys Val Ala Asp Ser Glu Gly Lys Ile Pro Val Arg Ala 
1105                1110                1115                1120

Tyr Ser Asn Ala Ser Ser Val Glu Leu Phe Leu Asn Gly Lys Ser Leu 
                1125                1130                1135    

Gly Leu Lys Thr Phe Asn Lys Lys Gln Thr Ser Asp Gly Arg Thr Tyr 
            1140                1145                1150        

Gln Glu Gly Ala Asn Ala Asn Glu Leu Tyr Leu Glu Trp Lys Val Ala 
        1155                1160                1165            

Tyr Gln Pro Gly Thr Leu Glu Ala Ile Ala Arg Asp Glu Ser Gly Lys 
    1170                1175                1180                

Glu Ile Ala Arg Asp Lys Ile Thr Thr Ala Gly Lys Pro Ala Ala Val 
1185                1190                1195                1200

Arg Leu Ile Lys Glu Asp His Ala Ile Ala Ala Asp Gly Lys Asp Leu 
                1205                1210                1215    

Thr Tyr Ile Tyr Tyr Glu Ile Val Asp Ser Gln Gly Asn Val Val Pro 
            1220                1225                1230        

Thr Ala Asn Asn Leu Val Arg Phe Gln Leu His Gly Gln Gly Gln Leu 
        1235                1240                1245            

Val Gly Val Asp Asn Gly Glu Gln Ala Ser Arg Glu Arg Tyr Lys Ala 
    1250                1255                1260                

Gln Ala Asp Gly Ser Trp Ile Arg Lys Ala Phe Asn Gly Lys Gly Val 
1265                1270                1275                1280

Ala Ile Val Lys Ser Thr Glu Gln Ala Gly Lys Phe Thr Leu Thr Ala 
                1285                1290                1295    

His Ser Asp Leu Leu Lys Ser Asn Gln Val Thr Val Phe Thr Gly Lys 
            1300                1305                1310        

Lys Glu Gly Gln Glu Lys Thr Val Leu Gly Thr Glu Val Pro Lys Val 
        1315                1320                1325            

Gln Thr Ile Ile Gly Glu Ala Pro Glu Met Pro Thr Thr Val Pro Phe 
    1330                1335                1340                

Val Tyr Ser Asp Gly Ser Arg Ala Glu Arg Pro Val Thr Trp Ser Ser 
1345                1350                1355                1360

Val Asp Val Ser Lys Pro Gly Ile Val Thr Val Lys Gly Met Ala Asp 
                1365                1370                1375    

Gly Arg Glu Val Glu Ala Arg Val Glu Val Ile Ala Leu Lys Ser Glu 
            1380                1385                1390        

Leu Pro Val Val Lys Arg Ile Ala Pro Asn Thr Asp Leu Asn Ser Val 
        1395                1400                1405            

Asp Lys Ser Val Ser Tyr Val Leu Ile Asp Gly Ser Val Glu Glu Tyr 
    1410                1415                1420                

Glu Val Asp Lys Trp Glu Ile Ala Glu Glu Asp Lys Ala Lys Ala Ala 
1425                1430                1435                1440

Ala Leu Glu His His His His His His 
                1445                

<210>   197
<211>   1484
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Hybrid polypeptide

<400>   197
Met Ala Glu Thr Thr Asp Asp Lys Ile Ala Ala Gln Asp Asn Lys Ile 
1               5                   10                  15      

Ser Asn Leu Thr Ala Gln Gln Gln Glu Ala Gln Lys Gln Val Asp Gln 
            20                  25                  30          

Ile Gln Glu Gln Val Ser Ala Ile Gln Ala Glu Gln Ser Asn Leu Gln 
        35                  40                  45              

Ala Glu Asn Asp Arg Leu Gln Ala Glu Ser Lys Lys Leu Glu Gly Glu 
    50                  55                  60                  

Ile Thr Glu Leu Ser Lys Asn Ile Val Ser Arg Asn Gln Ser Leu Glu 
65                  70                  75                  80  

Lys Gln Ala Arg Ser Ala Gln Thr Asn Gly Ala Val Thr Ser Tyr Ile 
                85                  90                  95      

Asn Thr Ile Val Asn Ser Lys Ser Ile Thr Glu Ala Ile Ser Arg Val 
            100                 105                 110         

Ala Ala Met Ser Glu Ile Val Ser Ala Asn Asn Lys Met Leu Glu Gln 
        115                 120                 125             

Gln Lys Ala Asp Lys Lys Ala Ile Ser Glu Lys Gln Val Ala Asn Asn 
    130                 135                 140                 

Asp Ala Ile Asn Thr Val Ile Ala Asn Gln Gln Lys Leu Ala Asp Asp 
145                 150                 155                 160 

Ala Gln Ala Leu Thr Thr Lys Gln Ala Glu Leu Lys Ala Ala Glu Leu 
                165                 170                 175     

Ser Leu Ala Ala Glu Lys Ala Thr Ala Glu Gly Glu Lys Ala Ser Leu 
            180                 185                 190         

Leu Glu Gln Lys Ala Ala Ala Glu Ala Glu Ala Arg Ala Ala Ala Val 
        195                 200                 205             

Ala Glu Ala Ala Tyr Lys Glu Lys Arg Ala Ser Gln Gln Gln Ser Val 
    210                 215                 220                 

Leu Ala Ser Ala Asn Thr Asn Leu Thr Ala Gln Val Gln Ala Val Ser 
225                 230                 235                 240 

Glu Ser Ala Ala Ala Pro Val Arg Ala Lys Val Arg Pro Thr Tyr Ser 
                245                 250                 255     

Thr Asn Ala Ser Ser Tyr Pro Ile Gly Glu Cys Thr Trp Gly Val Lys 
            260                 265                 270         

Thr Leu Ala Pro Trp Ala Gly Asp Tyr Trp Gly Asn Gly Ala Gln Trp 
        275                 280                 285             

Ala Thr Ser Ala Ala Ala Ala Gly Phe Arg Thr Gly Ser Thr Pro Gln 
    290                 295                 300                 

Val Gly Ala Ile Ala Cys Trp Asn Asp Gly Gly Tyr Gly His Val Ala 
305                 310                 315                 320 

Val Val Thr Ala Val Glu Ser Thr Thr Arg Ile Gln Val Ser Glu Ser 
                325                 330                 335     

Asn Tyr Ala Gly Asn Arg Thr Ile Gly Asn His Arg Gly Trp Phe Asn 
            340                 345                 350         

Pro Thr Thr Thr Ser Glu Gly Phe Val Thr Tyr Ile Tyr Ala Asp Gly 
        355                 360                 365             

Ser Gly Ser Gly Gly Gly Gly Ile Ala Glu Glu Asp Lys Ala Lys Leu 
    370                 375                 380                 

Ala Ile Pro Gly Ser Arg Ile Gln Ala Thr Gly Tyr Leu Glu Gly Gln 
385                 390                 395                 400 

Pro Ile His Ala Thr Leu Val Val Glu Glu Gly Asn Pro Ala Ala Pro 
                405                 410                 415     

Ala Val Pro Thr Val Thr Val Gly Gly Glu Ala Val Thr Gly Leu Thr 
            420                 425                 430         

Ser Gln Lys Pro Met Gln Tyr Arg Thr Leu Ala Tyr Gly Ala Lys Leu 
        435                 440                 445             

Pro Glu Val Thr Ala Ser Ala Lys Asn Ala Ala Val Thr Val Leu Gln 
    450                 455                 460                 

Ala Ser Ala Ala Asn Gly Met Arg Ala Ser Ile Phe Ile Gln Pro Lys 
465                 470                 475                 480 

Asp Gly Gly Pro Leu Gln Thr Tyr Ala Ile Gln Phe Leu Glu Glu Ala 
                485                 490                 495     

Pro Lys Ile Ala His Leu Ser Leu Gln Val Glu Lys Ala Asp Ser Leu 
            500                 505                 510         

Lys Glu Asp Gln Thr Val Lys Leu Ser Val Arg Ala His Tyr Gln Asp 
        515                 520                 525             

Gly Thr Gln Ala Val Leu Pro Ala Asp Lys Val Thr Phe Ser Thr Ser 
    530                 535                 540                 

Gly Glu Gly Glu Val Ala Ile Arg Lys Gly Met Leu Glu Leu His Lys 
545                 550                 555                 560 

Pro Gly Ala Val Thr Leu Asn Ala Glu Tyr Glu Gly Ala Lys Asp Gln 
                565                 570                 575     

Val Glu Leu Thr Ile Gln Ala Asn Thr Glu Lys Lys Ile Ala Gln Ser 
            580                 585                 590         

Ile Arg Pro Val Asn Val Val Thr Asp Leu His Gln Glu Pro Ser Leu 
        595                 600                 605             

Pro Ala Thr Val Thr Val Glu Tyr Asp Lys Gly Phe Pro Lys Thr His 
    610                 615                 620                 

Lys Val Thr Trp Gln Ala Ile Pro Lys Glu Lys Leu Asp Ser Tyr Gln 
625                 630                 635                 640 

Thr Phe Glu Val Leu Gly Lys Val Glu Gly Ile Asp Leu Glu Ala Arg 
                645                 650                 655     

Ala Lys Val Ser Val Glu Gly Ile Val Ser Val Glu Glu Val Ser Val 
            660                 665                 670         

Thr Thr Pro Ile Ala Glu Ala Pro Gln Leu Pro Glu Ser Val Arg Thr 
        675                 680                 685             

Tyr Asp Ser Asn Gly His Val Ser Ser Ala Lys Val Ala Trp Asp Ala 
    690                 695                 700                 

Ile Arg Pro Glu Gln Tyr Ala Lys Glu Gly Val Phe Thr Val Asn Gly 
705                 710                 715                 720 

Arg Leu Glu Gly Thr Gln Leu Thr Thr Lys Leu His Val Arg Val Ser 
                725                 730                 735     

Ala Gln Thr Glu Gln Gly Ala Asn Ile Ser Asp Gln Trp Thr Gly Ser 
            740                 745                 750         

Glu Leu Pro Leu Ala Phe Ala Ser Asp Ser Asn Pro Ser Asp Pro Val 
        755                 760                 765             

Ser Asn Val Asn Asp Lys Leu Ile Ser Tyr Asn Asn Gln Pro Ala Asn 
    770                 775                 780                 

Arg Trp Thr Asn Trp Asn Arg Thr Asn Pro Glu Ala Ser Val Gly Val 
785                 790                 795                 800 

Leu Phe Gly Asp Ser Gly Ile Leu Ser Lys Arg Ser Val Asp Asn Leu 
                805                 810                 815     

Ser Val Gly Phe His Glu Asp His Gly Val Gly Val Pro Lys Ser Tyr 
            820                 825                 830         

Val Ile Glu Tyr Tyr Val Gly Lys Thr Val Pro Thr Ala Pro Lys Asn 
        835                 840                 845             

Pro Ser Phe Val Gly Asn Glu Asp His Val Phe Asn Asp Ser Ala Asn 
    850                 855                 860                 

Trp Lys Pro Val Thr Asn Leu Lys Ala Pro Ala Gln Leu Lys Ala Gly 
865                 870                 875                 880 

Glu Met Asn His Phe Ser Phe Asp Lys Val Glu Thr Tyr Ala Val Arg 
                885                 890                 895     

Ile Arg Met Val Lys Ala Asp Asn Lys Arg Gly Thr Ser Ile Thr Glu 
            900                 905                 910         

Val Gln Ile Phe Ala Lys Gln Val Ala Ala Ala Lys Gln Gly Gln Thr 
        915                 920                 925             

Arg Ile Gln Val Asp Gly Lys Asp Leu Ala Asn Phe Asn Pro Asp Leu 
    930                 935                 940                 

Thr Asp Tyr Tyr Leu Glu Ser Val Asp Gly Lys Val Pro Ala Val Thr 
945                 950                 955                 960 

Ala Ser Val Ser Asn Asn Gly Leu Ala Thr Val Val Pro Ser Val Arg 
                965                 970                 975     

Glu Gly Glu Pro Val Arg Val Ile Ala Lys Ala Glu Asn Gly Asp Ile 
            980                 985                 990         

Leu Gly Glu Tyr Arg Leu His Phe Thr Lys Asp Lys Ser Leu Leu Ser 
        995                 1000                1005            

His Lys Pro Val Ala Ala Val Lys Gln Ala Arg Leu Leu Gln Val Gly 
    1010                1015                1020                

Gln Ala Leu Glu Leu Pro Thr Lys Val Pro Val Tyr Phe Thr Gly Lys 
1025                1030                1035                1040

Asp Gly Tyr Glu Thr Lys Asp Leu Thr Val Glu Trp Glu Glu Val Pro 
                1045                1050                1055    

Ala Glu Asn Leu Thr Lys Ala Gly Gln Phe Thr Val Arg Gly Arg Val 
            1060                1065                1070        

Leu Gly Ser Asn Leu Val Ala Glu Ile Thr Val Arg Val Thr Asp Lys 
        1075                1080                1085            

Leu Gly Glu Thr Leu Ser Asp Asn Pro Asn Tyr Asp Glu Asn Ser Asn 
    1090                1095                1100                

Gln Ala Phe Ala Ser Ala Thr Asn Asp Ile Asp Lys Asn Ser His Asp 
1105                1110                1115                1120

Arg Val Asp Tyr Leu Asn Asp Gly Asp His Ser Glu Asn Arg Arg Trp 
                1125                1130                1135    

Thr Asn Trp Ser Pro Thr Pro Ser Ser Asn Pro Glu Val Ser Ala Gly 
            1140                1145                1150        

Val Ile Phe Arg Glu Asn Gly Lys Ile Val Glu Arg Thr Val Thr Gln 
        1155                1160                1165            

Gly Lys Val Gln Phe Phe Ala Asp Ser Gly Thr Asp Ala Pro Ser Lys 
    1170                1175                1180                

Leu Val Leu Glu Arg Tyr Val Gly Pro Glu Phe Glu Val Pro Thr Tyr 
1185                1190                1195                1200

Tyr Ser Asn Tyr Gln Ala Tyr Asp Ala Asp His Pro Phe Asn Asn Pro 
                1205                1210                1215    

Glu Asn Trp Glu Ala Val Pro Tyr Arg Ala Asp Lys Asp Ile Ala Ala 
            1220                1225                1230        

Gly Asp Glu Ile Asn Val Thr Phe Lys Ala Ile Lys Ala Lys Ala Met 
        1235                1240                1245            

Arg Trp Arg Met Glu Arg Lys Ala Asp Lys Ser Gly Val Ala Met Ile 
    1250                1255                1260                

Glu Met Thr Phe Leu Ala Pro Ser Glu Leu Pro Gln Glu Ser Thr Gln 
1265                1270                1275                1280

Ser Lys Ile Leu Val Asp Gly Lys Glu Leu Ala Asp Phe Ala Glu Asn 
                1285                1290                1295    

Arg Gln Asp Tyr Gln Ile Thr Tyr Lys Gly Gln Arg Pro Lys Val Ser 
            1300                1305                1310        

Val Glu Glu Asn Asn Gln Val Ala Ser Thr Val Val Asp Ser Gly Glu 
        1315                1320                1325            

Asp Ser Phe Pro Val Leu Val Arg Leu Val Ser Glu Ser Gly Lys Gln 
    1330                1335                1340                

Val Lys Glu Tyr Arg Ile His Leu Thr Lys Glu Lys Pro Val Ser Glu 
1345                1350                1355                1360

Lys Thr Val Ala Ala Val Gln Glu Asp Leu Pro Lys Ile Glu Phe Val 
                1365                1370                1375    

Glu Lys Asp Leu Ala Tyr Lys Thr Val Glu Lys Lys Asp Ser Thr Leu 
            1380                1385                1390        

Tyr Leu Gly Glu Thr Arg Val Glu Gln Glu Gly Lys Val Gly Lys Glu 
        1395                1400                1405            

Arg Ile Phe Thr Ala Ile Asn Pro Asp Gly Ser Lys Glu Glu Lys Leu 
    1410                1415                1420                

Arg Glu Val Val Glu Val Pro Thr Asp Arg Ile Val Leu Val Gly Thr 
1425                1430                1435                1440

Lys Pro Val Ala Gln Glu Ala Lys Lys Pro Gln Val Ser Glu Lys Ala 
                1445                1450                1455    

Asp Thr Lys Pro Ile Asp Ser Ser Glu Ala Ser Gln Thr Asn Lys Ala 
            1460                1465                1470        

Gln Ala Ala Ala Leu Glu His His His His His His 
        1475                1480                

<210>   198
<211>   1209
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Hybrid polypeptide

<400>   198
Met Ala Ser Ala Glu Thr Thr Asp Asp Lys Ile Ala Ala Gln Asp Asn 
1               5                   10                  15      

Lys Ile Ser Asn Leu Thr Ala Gln Gln Gln Glu Ala Gln Lys Gln Val 
            20                  25                  30          

Asp Gln Ile Gln Glu Gln Val Ser Ala Ile Gln Ala Glu Gln Ser Asn 
        35                  40                  45              

Leu Gln Ala Glu Asn Asp Arg Leu Gln Ala Glu Ser Lys Lys Leu Glu 
    50                  55                  60                  

Gly Glu Ile Thr Glu Leu Ser Lys Asn Ile Val Ser Arg Asn Gln Ser 
65                  70                  75                  80  

Leu Glu Lys Gln Ala Arg Ser Ala Gln Thr Asn Gly Ala Val Thr Ser 
                85                  90                  95      

Tyr Ile Asn Thr Ile Val Asn Ser Lys Ser Ile Thr Glu Ala Ile Ser 
            100                 105                 110         

Arg Val Ala Ala Met Ser Glu Ile Val Ser Ala Asn Asn Lys Met Leu 
        115                 120                 125             

Glu Gln Gln Lys Ala Asp Lys Lys Ala Ile Ser Glu Lys Gln Val Ala 
    130                 135                 140                 

Asn Asn Asp Ala Ile Asn Thr Val Ile Ala Asn Gln Gln Lys Leu Ala 
145                 150                 155                 160 

Asp Asp Ala Gln Ala Leu Thr Thr Lys Gln Ala Glu Leu Lys Ala Ala 
                165                 170                 175     

Glu Leu Ser Leu Ala Ala Glu Lys Ala Thr Ala Glu Gly Glu Lys Ala 
            180                 185                 190         

Ser Leu Leu Glu Gln Lys Ala Ala Ala Glu Ala Glu Ala Arg Ala Ala 
        195                 200                 205             

Ala Val Ala Glu Ala Ala Tyr Lys Glu Lys Arg Ala Ser Gln Gln Gln 
    210                 215                 220                 

Ser Val Leu Ala Ser Ala Asn Thr Asn Leu Thr Ala Gln Val Gln Ala 
225                 230                 235                 240 

Val Ser Glu Ser Ala Ala Ala Pro Val Arg Ala Lys Val Arg Pro Thr 
                245                 250                 255     

Tyr Ser Thr Asn Ala Ser Ser Tyr Pro Ile Gly Glu Cys Thr Trp Gly 
            260                 265                 270         

Val Lys Thr Leu Ala Pro Trp Ala Gly Asp Tyr Trp Gly Asn Gly Ala 
        275                 280                 285             

Gln Trp Ala Thr Ser Ala Ala Ala Ala Gly Phe Arg Thr Gly Ser Thr 
    290                 295                 300                 

Pro Gln Val Gly Ala Ile Ala Cys Trp Asn Asp Gly Gly Tyr Gly His 
305                 310                 315                 320 

Val Ala Val Val Thr Ala Val Glu Ser Thr Thr Arg Ile Gln Val Ser 
                325                 330                 335     

Glu Ser Asn Tyr Ala Gly Asn Arg Thr Ile Gly Asn His Arg Gly Trp 
            340                 345                 350         

Phe Asn Pro Thr Thr Thr Ser Glu Gly Phe Val Thr Tyr Ile Tyr Ala 
        355                 360                 365             

Asp Gly Ser Gly Ser Gly Gly Gly Gly Glu Thr Pro Glu Thr Ser Pro 
    370                 375                 380                 

Ala Ile Gly Lys Val Val Ile Lys Glu Thr Gly Glu Gly Gly Ala Leu 
385                 390                 395                 400 

Leu Gly Asp Ala Val Phe Glu Leu Lys Asn Asn Thr Asp Gly Thr Thr 
                405                 410                 415     

Val Ser Gln Arg Thr Glu Ala Gln Thr Gly Glu Ala Ile Phe Ser Asn 
            420                 425                 430         

Ile Lys Pro Gly Thr Tyr Thr Leu Thr Glu Ala Gln Pro Pro Val Gly 
        435                 440                 445             

Tyr Lys Pro Ser Thr Lys Gln Trp Thr Val Glu Val Glu Lys Asn Gly 
    450                 455                 460                 

Arg Thr Thr Val Gln Gly Glu Gln Val Glu Asn Arg Glu Glu Ala Leu 
465                 470                 475                 480 

Ser Asp Gln Tyr Pro Gln Thr Gly Thr Tyr Pro Asp Val Gln Thr Pro 
                485                 490                 495     

Tyr Gln Ile Ile Lys Val Asp Gly Ser Glu Lys Asn Gly Gln His Lys 
            500                 505                 510         

Ala Leu Asn Pro Asn Pro Tyr Glu Arg Val Ile Pro Glu Gly Thr Leu 
        515                 520                 525             

Ser Lys Arg Ile Tyr Gln Val Asn Asn Leu Asp Asp Asn Gln Tyr Gly 
    530                 535                 540                 

Ile Glu Leu Thr Val Ser Gly Lys Thr Val Tyr Glu Gln Lys Asp Lys 
545                 550                 555                 560 

Ser Val Pro Leu Asp Val Val Ile Leu Leu Asp Asn Ser Asn Ser Met 
                565                 570                 575     

Ser Asn Ile Arg Asn Lys Asn Ala Arg Arg Ala Glu Arg Ala Gly Glu 
            580                 585                 590         

Ala Thr Arg Ser Leu Ile Asp Lys Ile Thr Ser Asp Ser Glu Asn Arg 
        595                 600                 605             

Val Ala Leu Val Thr Tyr Ala Ser Thr Ile Phe Asp Gly Thr Glu Phe 
    610                 615                 620                 

Thr Val Glu Lys Gly Val Ala Asp Lys Asn Gly Lys Arg Leu Asn Asp 
625                 630                 635                 640 

Ser Leu Phe Trp Asn Tyr Asp Gln Thr Ser Phe Thr Thr Asn Thr Lys 
                645                 650                 655     

Asp Tyr Ser Tyr Leu Lys Leu Thr Asn Asp Lys Asn Asp Ile Val Glu 
            660                 665                 670         

Leu Lys Asn Lys Val Pro Thr Glu Ala Glu Asp His Asp Gly Asn Arg 
        675                 680                 685             

Leu Met Tyr Gln Phe Gly Ala Thr Phe Thr Gln Lys Ala Leu Met Lys 
    690                 695                 700                 

Ala Asp Glu Ile Leu Thr Gln Gln Ala Arg Gln Asn Ser Gln Lys Val 
705                 710                 715                 720 

Ile Phe His Ile Thr Asp Gly Val Pro Thr Met Ser Tyr Pro Ile Asn 
                725                 730                 735     

Phe Asn His Ala Thr Phe Ala Pro Ser Tyr Gln Asn Gln Leu Asn Ala 
            740                 745                 750         

Phe Phe Ser Lys Ser Pro Asn Lys Asp Gly Ile Leu Leu Ser Asp Phe 
        755                 760                 765             

Ile Thr Gln Ala Thr Ser Gly Glu His Thr Ile Val Arg Gly Asp Gly 
    770                 775                 780                 

Gln Ser Tyr Gln Met Phe Thr Asp Lys Thr Val Tyr Glu Lys Gly Ala 
785                 790                 795                 800 

Pro Ala Ala Phe Pro Val Lys Pro Glu Lys Tyr Ser Glu Met Lys Ala 
                805                 810                 815     

Ala Gly Tyr Ala Val Ile Gly Asp Pro Ile Asn Gly Gly Tyr Ile Trp 
            820                 825                 830         

Leu Asn Trp Arg Glu Ser Ile Leu Ala Tyr Pro Phe Asn Ser Asn Thr 
        835                 840                 845             

Ala Lys Ile Thr Asn His Gly Asp Pro Thr Arg Trp Tyr Tyr Asn Gly 
    850                 855                 860                 

Asn Ile Ala Pro Asp Gly Tyr Asp Val Phe Thr Val Gly Ile Gly Ile 
865                 870                 875                 880 

Asn Gly Asp Pro Gly Thr Asp Glu Ala Thr Ala Thr Ser Phe Met Gln 
                885                 890                 895     

Ser Ile Ser Ser Lys Pro Glu Asn Tyr Thr Asn Val Thr Asp Thr Thr 
            900                 905                 910         

Lys Ile Leu Glu Gln Leu Asn Arg Tyr Phe His Thr Ile Val Thr Glu 
        915                 920                 925             

Lys Lys Ser Ile Glu Asn Gly Thr Ile Thr Asp Pro Met Gly Glu Leu 
    930                 935                 940                 

Ile Asp Leu Gln Leu Gly Thr Asp Gly Arg Phe Asp Pro Ala Asp Tyr 
945                 950                 955                 960 

Thr Leu Thr Ala Asn Asp Gly Ser Arg Leu Glu Asn Gly Gln Ala Val 
                965                 970                 975     

Gly Gly Pro Gln Asn Asp Gly Gly Leu Leu Lys Asn Ala Lys Val Leu 
            980                 985                 990         

Tyr Asp Thr Thr Glu Lys Arg Ile Arg Val Thr Gly Leu Tyr Leu Gly 
        995                 1000                1005            

Thr Asp Glu Lys Val Thr Leu Thr Tyr Asn Val Arg Leu Asn Asp Glu 
    1010                1015                1020                

Phe Val Ser Asn Lys Phe Tyr Asp Thr Asn Gly Arg Thr Thr Leu His 
1025                1030                1035                1040

Pro Lys Glu Val Glu Gln Asn Thr Val Arg Asp Phe Pro Ile Pro Lys 
                1045                1050                1055    

Ile Arg Asp Val Arg Lys Tyr Pro Glu Ile Thr Ile Ser Lys Glu Lys 
            1060                1065                1070        

Lys Leu Gly Asp Ile Glu Phe Ile Lys Val Asn Lys Asn Asp Lys Lys 
        1075                1080                1085            

Pro Leu Arg Gly Ala Val Phe Ser Leu Gln Lys Gln His Pro Asp Tyr 
    1090                1095                1100                

Pro Asp Ile Tyr Gly Ala Ile Asp Gln Asn Gly Thr Tyr Gln Asn Val 
1105                1110                1115                1120

Arg Thr Gly Glu Asp Gly Lys Leu Thr Phe Lys Asn Leu Ser Asp Gly 
                1125                1130                1135    

Lys Tyr Arg Leu Phe Glu Asn Ser Glu Pro Ala Gly Tyr Lys Pro Val 
            1140                1145                1150        

Gln Asn Lys Pro Ile Val Ala Phe Gln Ile Val Asn Gly Glu Val Arg 
        1155                1160                1165            

Asp Val Thr Ser Ile Val Pro Gln Asp Ile Pro Ala Gly Tyr Glu Phe 
    1170                1175                1180                

Thr Asn Asp Lys His Tyr Ile Thr Asn Glu Pro Ile Pro Pro Lys Arg 
1185                1190                1195                1200

Glu Leu Glu His His His His His His 
                1205                

<210>   199
<211>   1633
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Hybrid polypeptide

<400>   199
Met Ala Asp Gly Val Thr Pro Thr Thr Thr Glu Asn Gln Pro Thr Ile 
1               5                   10                  15      

His Thr Val Ser Asp Ser Pro Gln Ser Ser Glu Asn Arg Thr Glu Glu 
            20                  25                  30          

Thr Pro Lys Ala Val Leu Gln Pro Glu Ala Pro Lys Thr Val Glu Thr 
        35                  40                  45              

Glu Thr Pro Ala Thr Asp Lys Val Ala Ser Leu Pro Lys Thr Glu Glu 
    50                  55                  60                  

Lys Pro Gln Glu Glu Val Ser Ser Thr Pro Ser Asp Lys Ala Glu Val 
65                  70                  75                  80  

Val Thr Pro Thr Ser Ala Glu Lys Glu Thr Ala Asn Lys Lys Ala Glu 
                85                  90                  95      

Glu Ala Ser Pro Lys Lys Glu Glu Ala Lys Glu Val Asp Ser Lys Glu 
            100                 105                 110         

Ser Asn Thr Asp Lys Thr Asp Lys Asp Lys Pro Ala Lys Lys Asp Glu 
        115                 120                 125             

Ala Lys Ala Glu Ala Asp Lys Pro Ala Thr Glu Ala Gly Lys Glu Arg 
    130                 135                 140                 

Ala Ala Thr Val Asn Glu Lys Leu Ala Lys Lys Lys Ile Val Ser Ile 
145                 150                 155                 160 

Asp Ala Gly Arg Lys Tyr Phe Ser Pro Glu Gln Leu Lys Glu Ile Ile 
                165                 170                 175     

Asp Lys Ala Lys His Tyr Gly Tyr Thr Asp Leu His Leu Leu Val Gly 
            180                 185                 190         

Asn Asp Gly Leu Arg Phe Met Leu Asp Asp Met Ser Ile Thr Ala Asn 
        195                 200                 205             

Gly Lys Thr Tyr Ala Ser Asp Asp Val Lys Arg Ala Ile Glu Lys Gly 
    210                 215                 220                 

Thr Asn Asp Tyr Tyr Asn Asp Pro Asn Gly Asn His Leu Thr Glu Ser 
225                 230                 235                 240 

Gln Met Thr Asp Leu Ile Asn Tyr Ala Lys Asp Lys Gly Ile Gly Leu 
                245                 250                 255     

Ile Pro Thr Val Asn Ser Pro Gly His Met Asp Ala Ile Leu Asn Ala 
            260                 265                 270         

Met Lys Glu Leu Gly Ile Gln Asn Pro Asn Phe Ser Tyr Phe Gly Lys 
        275                 280                 285             

Lys Ser Ala Arg Thr Val Asp Leu Asp Asn Glu Gln Ala Val Ala Phe 
    290                 295                 300                 

Thr Lys Ala Leu Ile Asp Lys Tyr Ala Ala Tyr Phe Ala Lys Lys Thr 
305                 310                 315                 320 

Glu Ile Phe Asn Ile Gly Leu Asp Glu Tyr Ala Asn Asp Ala Thr Asp 
                325                 330                 335     

Ala Lys Gly Trp Ser Val Leu Gln Ala Asp Lys Tyr Tyr Pro Asn Glu 
            340                 345                 350         

Gly Tyr Pro Val Lys Gly Tyr Glu Lys Phe Ile Ala Tyr Ala Asn Asp 
        355                 360                 365             

Leu Ala Arg Ile Val Lys Ser His Gly Leu Lys Pro Met Ala Phe Asn 
    370                 375                 380                 

Asp Gly Ile Tyr Tyr Asn Ser Asp Thr Ser Phe Gly Ser Phe Asp Lys 
385                 390                 395                 400 

Asp Ile Ile Val Ser Met Trp Thr Gly Gly Trp Gly Gly Tyr Asp Val 
                405                 410                 415     

Ala Ser Ser Lys Leu Leu Ala Glu Lys Gly His Gln Ile Leu Asn Thr 
            420                 425                 430         

Asn Asp Ala Trp Tyr Tyr Val Leu Gly Arg Asn Ala Asp Gly Gln Gly 
        435                 440                 445             

Trp Tyr Asn Leu Asp Gln Gly Leu Asn Gly Ile Lys Asn Thr Pro Ile 
    450                 455                 460                 

Thr Ser Val Pro Lys Thr Glu Gly Ala Asp Ile Pro Ile Ile Gly Gly 
465                 470                 475                 480 

Met Val Ala Ala Trp Ala Asp Thr Pro Ser Ala Arg Tyr Ser Pro Ser 
                485                 490                 495     

Arg Leu Phe Lys Leu Met Arg His Phe Ala Asn Ala Asn Ala Glu Tyr 
            500                 505                 510         

Phe Ala Ala Asp Tyr Glu Ser Ala Glu Gln Ala Leu Asn Glu Val Pro 
        515                 520                 525             

Lys Asp Leu Asn Arg Tyr Thr Ala Glu Ser Val Thr Ala Val Lys Glu 
    530                 535                 540                 

Ala Glu Lys Ala Ile Arg Ser Leu Asp Ser Asn Leu Ser Arg Ala Gln 
545                 550                 555                 560 

Gln Asp Thr Ile Asp Gln Ala Ile Ala Lys Leu Gln Glu Thr Val Asn 
                565                 570                 575     

Asn Leu Thr Leu Thr Pro Glu Ala Gln Lys Glu Glu Glu Ala Lys Arg 
            580                 585                 590         

Glu Val Glu Lys Leu Ala Lys Asn Lys Val Ile Ser Ile Asp Ala Gly 
        595                 600                 605             

Arg Lys Tyr Phe Thr Leu Asn Gln Leu Lys Arg Ile Val Asp Lys Ala 
    610                 615                 620                 

Ser Glu Leu Gly Tyr Ser Asp Val His Leu Leu Leu Gly Asn Asp Gly 
625                 630                 635                 640 

Leu Arg Phe Leu Leu Asp Asp Met Thr Ile Thr Ala Asn Gly Lys Thr 
                645                 650                 655     

Tyr Ala Ser Asp Asp Val Lys Lys Ala Ile Ile Glu Gly Thr Lys Ala 
            660                 665                 670         

Tyr Tyr Asp Asp Pro Asn Gly Thr Ala Leu Thr Gln Ala Glu Val Thr 
        675                 680                 685             

Glu Leu Ile Glu Tyr Ala Lys Ser Lys Asp Ile Gly Leu Ile Pro Ala 
    690                 695                 700                 

Ile Asn Ser Pro Gly His Met Asp Ala Met Leu Val Ala Met Glu Lys 
705                 710                 715                 720 

Leu Gly Ile Lys Asn Pro Gln Ala His Phe Asp Lys Val Ser Lys Thr 
                725                 730                 735     

Thr Met Asp Leu Lys Asn Glu Glu Ala Met Asn Phe Val Lys Ala Leu 
            740                 745                 750         

Ile Gly Lys Tyr Met Asp Phe Phe Ala Gly Lys Thr Lys Ile Phe Asn 
        755                 760                 765             

Phe Gly Thr Asp Glu Tyr Ala Asn Asp Ala Thr Ser Ala Gln Gly Trp 
    770                 775                 780                 

Tyr Tyr Leu Lys Trp Tyr Gln Leu Tyr Gly Lys Phe Ala Glu Tyr Ala 
785                 790                 795                 800 

Asn Thr Leu Ala Ala Met Ala Lys Glu Arg Gly Leu Gln Pro Met Ala 
                805                 810                 815     

Phe Asn Asp Gly Phe Tyr Tyr Glu Asp Lys Asp Asp Val Gln Phe Asp 
            820                 825                 830         

Lys Asp Val Leu Ile Ser Tyr Trp Ser Lys Gly Trp Trp Gly Tyr Asn 
        835                 840                 845             

Leu Ala Ser Pro Gln Tyr Leu Ala Ser Lys Gly Tyr Lys Phe Leu Asn 
    850                 855                 860                 

Thr Asn Gly Asp Trp Tyr Tyr Ile Leu Gly Gln Lys Pro Glu Asp Gly 
865                 870                 875                 880 

Gly Gly Phe Leu Lys Lys Ala Ile Glu Asn Thr Gly Lys Thr Pro Phe 
                885                 890                 895     

Asn Gln Leu Ala Ser Thr Lys Tyr Pro Glu Val Asp Leu Pro Thr Val 
            900                 905                 910         

Gly Ser Met Leu Ser Ile Trp Ala Asp Arg Pro Ser Ala Glu Tyr Lys 
        915                 920                 925             

Glu Glu Glu Ile Phe Glu Leu Met Thr Ala Phe Ala Asp His Asn Lys 
    930                 935                 940                 

Asp Tyr Phe Arg Ala Asn Tyr Asn Ala Leu Arg Glu Glu Leu Ala Lys 
945                 950                 955                 960 

Ile Pro Thr Asn Leu Glu Gly Tyr Ser Lys Glu Ser Leu Glu Ala Leu 
                965                 970                 975     

Asp Ala Ala Lys Thr Ala Leu Asn Tyr Asn Leu Asn Arg Asn Lys Gln 
            980                 985                 990         

Ala Glu Leu Asp Thr Leu Val Ala Asn Leu Lys Ala Ala Leu Gln Gly 
        995                 1000                1005            

Leu Lys Pro Ala Val Thr His Ser Gly Ser Leu Asp Glu Asn Glu Val 
    1010                1015                1020                

Ala Ala Asn Val Glu Thr Arg Pro Glu Leu Ile Thr Arg Thr Glu Glu 
1025                1030                1035                1040

Ile Pro Phe Glu Val Ile Lys Lys Glu Asn Pro Asn Leu Pro Ala Gly 
                1045                1050                1055    

Gln Glu Asn Ile Ile Thr Ala Gly Val Lys Gly Glu Arg Thr His Tyr 
            1060                1065                1070        

Ile Ser Val Leu Thr Glu Asn Gly Lys Thr Thr Glu Thr Val Leu Asp 
        1075                1080                1085            

Ser Gln Val Thr Lys Glu Val Ile Asn Gln Val Val Glu Val Gly Ala 
    1090                1095                1100                

Pro Val Thr His Lys Gly Asp Glu Ser Gly Leu Ala Pro Thr Thr Glu 
1105                1110                1115                1120

Val Lys Pro Arg Leu Asp Ile Gln Glu Glu Glu Ile Pro Phe Thr Thr 
                1125                1130                1135    

Val Thr Cys Glu Asn Pro Leu Leu Leu Lys Gly Lys Thr Gln Val Ile 
            1140                1145                1150        

Thr Lys Gly Val Asn Gly His Arg Ser Asn Phe Tyr Ser Val Ser Thr 
        1155                1160                1165            

Ser Ala Asp Gly Lys Glu Val Lys Thr Leu Val Asn Ser Val Val Ala 
    1170                1175                1180                

Gln Glu Ala Val Thr Gln Ile Val Glu Val Gly Thr Met Val Thr His 
1185                1190                1195                1200

Val Gly Asp Glu Asn Gly Gln Ala Ala Ile Ala Glu Glu Lys Pro Lys 
                1205                1210                1215    

Leu Glu Ile Pro Ser Gln Pro Ala Pro Ser Thr Ala Pro Ala Glu Glu 
            1220                1225                1230        

Ser Lys Val Leu Pro Gln Asp Pro Ala Pro Val Val Thr Glu Lys Lys 
        1235                1240                1245            

Gly Ser Gly Ser Gly Gly Gly Gly Ala Glu Thr Thr Asp Asp Lys Ile 
    1250                1255                1260                

Ala Ala Gln Asp Asn Lys Ile Ser Asn Leu Thr Ala Gln Gln Gln Glu 
1265                1270                1275                1280

Ala Gln Lys Gln Val Asp Gln Ile Gln Glu Gln Val Ser Ala Ile Gln 
                1285                1290                1295    

Ala Glu Gln Ser Asn Leu Gln Ala Glu Asn Asp Arg Leu Gln Ala Glu 
            1300                1305                1310        

Ser Lys Lys Leu Glu Gly Glu Ile Thr Glu Leu Ser Lys Asn Ile Val 
        1315                1320                1325            

Ser Arg Asn Gln Ser Leu Glu Lys Gln Ala Arg Ser Ala Gln Thr Asn 
    1330                1335                1340                

Gly Ala Val Thr Ser Tyr Ile Asn Thr Ile Val Asn Ser Lys Ser Ile 
1345                1350                1355                1360

Thr Glu Ala Ile Ser Arg Val Ala Ala Met Ser Glu Ile Val Ser Ala 
                1365                1370                1375    

Asn Asn Lys Met Leu Glu Gln Gln Lys Ala Asp Lys Lys Ala Ile Ser 
            1380                1385                1390        

Glu Lys Gln Val Ala Asn Asn Asp Ala Ile Asn Thr Val Ile Ala Asn 
        1395                1400                1405            

Gln Gln Lys Leu Ala Asp Asp Ala Gln Ala Leu Thr Thr Lys Gln Ala 
    1410                1415                1420                

Glu Leu Lys Ala Ala Glu Leu Ser Leu Ala Ala Glu Lys Ala Thr Ala 
1425                1430                1435                1440

Glu Gly Glu Lys Ala Ser Leu Leu Glu Gln Lys Ala Ala Ala Glu Ala 
                1445                1450                1455    

Glu Ala Arg Ala Ala Ala Val Ala Glu Ala Ala Tyr Lys Glu Lys Arg 
            1460                1465                1470        

Ala Ser Gln Gln Gln Ser Val Leu Ala Ser Ala Asn Thr Asn Leu Thr 
        1475                1480                1485            

Ala Gln Val Gln Ala Val Ser Glu Ser Ala Ala Ala Pro Val Arg Ala 
    1490                1495                1500                

Lys Val Arg Pro Thr Tyr Ser Thr Asn Ala Ser Ser Tyr Pro Ile Gly 
1505                1510                1515                1520

Glu Cys Thr Trp Gly Val Lys Thr Leu Ala Pro Trp Ala Gly Asp Tyr 
                1525                1530                1535    

Trp Gly Asn Gly Ala Gln Trp Ala Thr Ser Ala Ala Ala Ala Gly Phe 
            1540                1545                1550        

Arg Thr Gly Ser Thr Pro Gln Val Gly Ala Ile Ala Cys Trp Asn Asp 
        1555                1560                1565            

Gly Gly Tyr Gly His Val Ala Val Val Thr Ala Val Glu Ser Thr Thr 
    1570                1575                1580                

Arg Ile Gln Val Ser Glu Ser Asn Tyr Ala Gly Asn Arg Thr Ile Gly 
1585                1590                1595                1600

Asn His Arg Gly Trp Phe Asn Pro Thr Thr Thr Ser Glu Gly Phe Val 
                1605                1610                1615    

Thr Tyr Ile Tyr Ala Asp Ala Ala Ala Leu Glu His His His His His 
            1620                1625                1630        

His 
    

<210>   200
<211>   1433
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Hybrid polypeptide

<400>   200
Met Ala Asp Gly Val Thr Pro Thr Thr Thr Glu Asn Gln Pro Thr Ile 
1               5                   10                  15      

His Thr Val Ser Asp Ser Pro Gln Ser Ser Glu Asn Arg Thr Glu Glu 
            20                  25                  30          

Thr Pro Lys Ala Val Leu Gln Pro Glu Ala Pro Lys Thr Val Glu Thr 
        35                  40                  45              

Glu Thr Pro Ala Thr Asp Lys Val Ala Ser Leu Pro Lys Thr Glu Glu 
    50                  55                  60                  

Lys Pro Gln Glu Glu Val Ser Ser Thr Pro Ser Asp Lys Ala Glu Val 
65                  70                  75                  80  

Val Thr Pro Thr Ser Ala Glu Lys Glu Thr Ala Asn Lys Lys Ala Glu 
                85                  90                  95      

Glu Ala Ser Pro Lys Lys Glu Glu Ala Lys Glu Val Asp Ser Lys Glu 
            100                 105                 110         

Ser Asn Thr Asp Lys Thr Asp Lys Asp Lys Pro Ala Lys Lys Asp Glu 
        115                 120                 125             

Ala Lys Ala Glu Ala Asp Lys Pro Ala Thr Glu Ala Gly Lys Glu Arg 
    130                 135                 140                 

Ala Ala Thr Val Asn Glu Lys Leu Ala Lys Lys Lys Ile Val Ser Ile 
145                 150                 155                 160 

Asp Ala Gly Arg Lys Tyr Phe Ser Pro Glu Gln Leu Lys Glu Ile Ile 
                165                 170                 175     

Asp Lys Ala Lys His Tyr Gly Tyr Thr Asp Leu His Leu Leu Val Gly 
            180                 185                 190         

Asn Asp Gly Leu Arg Phe Met Leu Asp Asp Met Ser Ile Thr Ala Asn 
        195                 200                 205             

Gly Lys Thr Tyr Ala Ser Asp Asp Val Lys Arg Ala Ile Glu Lys Gly 
    210                 215                 220                 

Thr Asn Asp Tyr Tyr Asn Asp Pro Asn Gly Asn His Leu Thr Glu Ser 
225                 230                 235                 240 

Gln Met Thr Asp Leu Ile Asn Tyr Ala Lys Asp Lys Gly Ile Gly Leu 
                245                 250                 255     

Ile Pro Thr Val Asn Ser Pro Gly His Met Asp Ala Ile Leu Asn Ala 
            260                 265                 270         

Met Lys Glu Leu Gly Ile Gln Asn Pro Asn Phe Ser Tyr Phe Gly Lys 
        275                 280                 285             

Lys Ser Ala Arg Thr Val Asp Leu Asp Asn Glu Gln Ala Val Ala Phe 
    290                 295                 300                 

Thr Lys Ala Leu Ile Asp Lys Tyr Ala Ala Tyr Phe Ala Lys Lys Thr 
305                 310                 315                 320 

Glu Ile Phe Asn Ile Gly Leu Asp Glu Tyr Ala Asn Asp Ala Thr Asp 
                325                 330                 335     

Ala Lys Gly Trp Ser Val Leu Gln Ala Asp Lys Tyr Tyr Pro Asn Glu 
            340                 345                 350         

Gly Tyr Pro Val Lys Gly Tyr Glu Lys Phe Ile Ala Tyr Ala Asn Asp 
        355                 360                 365             

Leu Ala Arg Ile Val Lys Ser His Gly Leu Lys Pro Met Ala Phe Asn 
    370                 375                 380                 

Asp Gly Ile Tyr Tyr Asn Ser Asp Thr Ser Phe Gly Ser Phe Asp Lys 
385                 390                 395                 400 

Asp Ile Ile Val Ser Met Trp Thr Gly Gly Trp Gly Gly Tyr Asp Val 
                405                 410                 415     

Ala Ser Ser Lys Leu Leu Ala Glu Lys Gly His Gln Ile Leu Asn Thr 
            420                 425                 430         

Asn Asp Ala Trp Tyr Tyr Val Leu Gly Arg Asn Ala Asp Gly Gln Gly 
        435                 440                 445             

Trp Tyr Asn Leu Asp Gln Gly Leu Asn Gly Ile Lys Asn Thr Pro Ile 
    450                 455                 460                 

Thr Ser Val Pro Lys Thr Glu Gly Ala Asp Ile Pro Ile Ile Gly Gly 
465                 470                 475                 480 

Met Val Ala Ala Trp Ala Asp Thr Pro Ser Ala Arg Tyr Ser Pro Ser 
                485                 490                 495     

Arg Leu Phe Lys Leu Met Arg His Phe Ala Asn Ala Asn Ala Glu Tyr 
            500                 505                 510         

Phe Ala Ala Asp Tyr Glu Ser Ala Glu Gln Ala Leu Asn Glu Val Pro 
        515                 520                 525             

Lys Asp Leu Asn Arg Tyr Thr Ala Glu Ser Val Thr Ala Val Lys Glu 
    530                 535                 540                 

Ala Glu Lys Ala Ile Arg Ser Leu Asp Ser Asn Leu Ser Arg Ala Gln 
545                 550                 555                 560 

Gln Asp Thr Ile Asp Gln Ala Ile Ala Lys Leu Gln Glu Thr Val Asn 
                565                 570                 575     

Asn Leu Thr Leu Thr Pro Glu Ala Gln Lys Glu Glu Glu Ala Lys Arg 
            580                 585                 590         

Glu Val Glu Lys Leu Ala Lys Asn Lys Val Ile Ser Ile Asp Ala Gly 
        595                 600                 605             

Arg Lys Tyr Phe Thr Leu Asn Gln Leu Lys Arg Ile Val Asp Lys Ala 
    610                 615                 620                 

Ser Glu Leu Gly Tyr Ser Asp Val His Leu Leu Leu Gly Asn Asp Gly 
625                 630                 635                 640 

Leu Arg Phe Leu Leu Asp Asp Met Thr Ile Thr Ala Asn Gly Lys Thr 
                645                 650                 655     

Tyr Ala Ser Asp Asp Val Lys Lys Ala Ile Ile Glu Gly Thr Lys Ala 
            660                 665                 670         

Tyr Tyr Asp Asp Pro Asn Gly Thr Ala Leu Thr Gln Ala Glu Val Thr 
        675                 680                 685             

Glu Leu Ile Glu Tyr Ala Lys Ser Lys Asp Ile Gly Leu Ile Pro Ala 
    690                 695                 700                 

Ile Asn Ser Pro Gly His Met Asp Ala Met Leu Val Ala Met Glu Lys 
705                 710                 715                 720 

Leu Gly Ile Lys Asn Pro Gln Ala His Phe Asp Lys Val Ser Lys Thr 
                725                 730                 735     

Thr Met Asp Leu Lys Asn Glu Glu Ala Met Asn Phe Val Lys Ala Leu 
            740                 745                 750         

Ile Gly Lys Tyr Met Asp Phe Phe Ala Gly Lys Thr Lys Ile Phe Asn 
        755                 760                 765             

Phe Gly Thr Asp Glu Tyr Ala Asn Asp Ala Thr Ser Ala Gln Gly Trp 
    770                 775                 780                 

Tyr Tyr Leu Lys Trp Tyr Gln Leu Tyr Gly Lys Phe Ala Glu Tyr Ala 
785                 790                 795                 800 

Asn Thr Leu Ala Ala Met Ala Lys Glu Arg Gly Leu Gln Pro Met Ala 
                805                 810                 815     

Phe Asn Asp Gly Phe Tyr Tyr Glu Asp Lys Asp Asp Val Gln Phe Asp 
            820                 825                 830         

Lys Asp Val Leu Ile Ser Tyr Trp Ser Lys Gly Trp Trp Gly Tyr Asn 
        835                 840                 845             

Leu Ala Ser Pro Gln Tyr Leu Ala Ser Lys Gly Tyr Lys Phe Leu Asn 
    850                 855                 860                 

Thr Asn Gly Asp Trp Tyr Tyr Ile Leu Gly Gln Lys Pro Glu Asp Gly 
865                 870                 875                 880 

Gly Gly Phe Leu Lys Lys Ala Ile Glu Asn Thr Gly Lys Thr Pro Phe 
                885                 890                 895     

Asn Gln Leu Ala Ser Thr Lys Tyr Pro Glu Val Asp Leu Pro Thr Val 
            900                 905                 910         

Gly Ser Met Leu Ser Ile Trp Ala Asp Arg Pro Ser Ala Glu Tyr Lys 
        915                 920                 925             

Glu Glu Glu Ile Phe Glu Leu Met Thr Ala Phe Ala Asp His Asn Lys 
    930                 935                 940                 

Asp Tyr Phe Arg Ala Asn Tyr Asn Ala Leu Arg Glu Glu Leu Ala Lys 
945                 950                 955                 960 

Ile Pro Thr Asn Leu Glu Gly Tyr Ser Lys Glu Ser Leu Glu Ala Leu 
                965                 970                 975     

Asp Ala Ala Lys Thr Ala Leu Asn Tyr Asn Leu Asn Arg Asn Lys Gln 
            980                 985                 990         

Ala Glu Leu Asp Thr Leu Val Ala Asn Leu Lys Ala Ala Leu Gln Gly 
        995                 1000                1005            

Leu Lys Pro Ala Val Thr His Ser Gly Ser Leu Asp Glu Asn Glu Val 
    1010                1015                1020                

Ala Ala Asn Val Glu Thr Arg Pro Glu Leu Ile Thr Arg Thr Glu Glu 
1025                1030                1035                1040

Ile Pro Phe Glu Val Ile Lys Lys Glu Asn Pro Asn Leu Pro Ala Gly 
                1045                1050                1055    

Gln Glu Asn Ile Ile Thr Ala Gly Val Lys Gly Glu Arg Thr His Tyr 
            1060                1065                1070        

Ile Ser Val Leu Thr Glu Asn Gly Lys Thr Thr Glu Thr Val Leu Asp 
        1075                1080                1085            

Ser Gln Val Thr Lys Glu Val Ile Asn Gln Val Val Glu Val Gly Ala 
    1090                1095                1100                

Pro Val Thr His Lys Gly Asp Glu Ser Gly Leu Ala Pro Thr Thr Glu 
1105                1110                1115                1120

Val Lys Pro Arg Leu Asp Ile Gln Glu Glu Glu Ile Pro Phe Thr Thr 
                1125                1130                1135    

Val Thr Cys Glu Asn Pro Leu Leu Leu Lys Gly Lys Thr Gln Val Ile 
            1140                1145                1150        

Thr Lys Gly Val Asn Gly His Arg Ser Asn Phe Tyr Ser Val Ser Thr 
        1155                1160                1165            

Ser Ala Asp Gly Lys Glu Val Lys Thr Leu Val Asn Ser Val Val Ala 
    1170                1175                1180                

Gln Glu Ala Val Thr Gln Ile Val Glu Val Gly Thr Met Val Thr His 
1185                1190                1195                1200

Val Gly Asp Glu Asn Gly Gln Ala Ala Ile Ala Glu Glu Lys Pro Lys 
                1205                1210                1215    

Leu Glu Ile Pro Ser Gln Pro Ala Pro Ser Thr Ala Pro Ala Glu Glu 
            1220                1225                1230        

Ser Lys Val Leu Pro Gln Asp Pro Ala Pro Val Val Thr Glu Lys Lys 
        1235                1240                1245            

Gly Ser Gly Ser Gly Gly Gly Gly Val Ser Ala Gln Glu Ser Ser Thr 
    1250                1255                1260                

Tyr Thr Val Lys Glu Gly Asp Thr Leu Ser Glu Ile Ala Glu Thr His 
1265                1270                1275                1280

Asn Thr Thr Val Glu Lys Leu Ala Glu Asn Asn His Ile Asp Asn Ile 
                1285                1290                1295    

His Leu Ile Tyr Val Asp Gln Glu Leu Val Ile Asp Gly Pro Val Ala 
            1300                1305                1310        

Pro Val Ala Thr Pro Ala Pro Ala Thr Tyr Ala Ala Pro Ala Ala Gln 
        1315                1320                1325            

Asp Glu Thr Val Ser Ala Pro Val Ala Glu Thr Pro Val Val Ser Glu 
    1330                1335                1340                

Thr Val Val Ser Thr Val Ser Gly Ser Glu Ala Glu Ala Lys Glu Trp 
1345                1350                1355                1360

Ile Ala Gln Lys Glu Ser Gly Gly Ser Tyr Thr Ala Thr Asn Gly Arg 
                1365                1370                1375    

Tyr Ile Gly Arg Tyr Gln Leu Thr Asp Ser Tyr Leu Asn Gly Asp Tyr 
            1380                1385                1390        

Ser Ala Glu Asn Gln Glu Arg Val Ala Asp Ala Tyr Val Ala Gly Arg 
        1395                1400                1405            

Tyr Gly Ser Trp Thr Ala Ala Lys Asn Phe Trp Leu Asn Asn Gly Trp 
    1410                1415                1420                

Tyr Leu Glu His His His His His His 
1425                1430            

<210>   201
<211>   2088
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Hybrid polypeptide

<400>   201
Met Ala Asp Gly Val Thr Pro Thr Thr Thr Glu Asn Gln Pro Thr Ile 
1               5                   10                  15      

His Thr Val Ser Asp Ser Pro Gln Ser Ser Glu Asn Arg Thr Glu Glu 
            20                  25                  30          

Thr Pro Lys Ala Val Leu Gln Pro Glu Ala Pro Lys Thr Val Glu Thr 
        35                  40                  45              

Glu Thr Pro Ala Thr Asp Lys Val Ala Ser Leu Pro Lys Thr Glu Glu 
    50                  55                  60                  

Lys Pro Gln Glu Glu Val Ser Ser Thr Pro Ser Asp Lys Ala Glu Val 
65                  70                  75                  80  

Val Thr Pro Thr Ser Ala Glu Lys Glu Thr Ala Asn Lys Lys Ala Glu 
                85                  90                  95      

Glu Ala Ser Pro Lys Lys Glu Glu Ala Lys Glu Val Asp Ser Lys Glu 
            100                 105                 110         

Ser Asn Thr Asp Lys Thr Asp Lys Asp Lys Pro Ala Lys Lys Asp Glu 
        115                 120                 125             

Ala Lys Ala Glu Ala Asp Lys Pro Ala Thr Glu Ala Gly Lys Glu Arg 
    130                 135                 140                 

Ala Ala Thr Val Asn Glu Lys Leu Ala Lys Lys Lys Ile Val Ser Ile 
145                 150                 155                 160 

Asp Ala Gly Arg Lys Tyr Phe Ser Pro Glu Gln Leu Lys Glu Ile Ile 
                165                 170                 175     

Asp Lys Ala Lys His Tyr Gly Tyr Thr Asp Leu His Leu Leu Val Gly 
            180                 185                 190         

Asn Asp Gly Leu Arg Phe Met Leu Asp Asp Met Ser Ile Thr Ala Asn 
        195                 200                 205             

Gly Lys Thr Tyr Ala Ser Asp Asp Val Lys Arg Ala Ile Glu Lys Gly 
    210                 215                 220                 

Thr Asn Asp Tyr Tyr Asn Asp Pro Asn Gly Asn His Leu Thr Glu Ser 
225                 230                 235                 240 

Gln Met Thr Asp Leu Ile Asn Tyr Ala Lys Asp Lys Gly Ile Gly Leu 
                245                 250                 255     

Ile Pro Thr Val Asn Ser Pro Gly His Met Asp Ala Ile Leu Asn Ala 
            260                 265                 270         

Met Lys Glu Leu Gly Ile Gln Asn Pro Asn Phe Ser Tyr Phe Gly Lys 
        275                 280                 285             

Lys Ser Ala Arg Thr Val Asp Leu Asp Asn Glu Gln Ala Val Ala Phe 
    290                 295                 300                 

Thr Lys Ala Leu Ile Asp Lys Tyr Ala Ala Tyr Phe Ala Lys Lys Thr 
305                 310                 315                 320 

Glu Ile Phe Asn Ile Gly Leu Asp Glu Tyr Ala Asn Asp Ala Thr Asp 
                325                 330                 335     

Ala Lys Gly Trp Ser Val Leu Gln Ala Asp Lys Tyr Tyr Pro Asn Glu 
            340                 345                 350         

Gly Tyr Pro Val Lys Gly Tyr Glu Lys Phe Ile Ala Tyr Ala Asn Asp 
        355                 360                 365             

Leu Ala Arg Ile Val Lys Ser His Gly Leu Lys Pro Met Ala Phe Asn 
    370                 375                 380                 

Asp Gly Ile Tyr Tyr Asn Ser Asp Thr Ser Phe Gly Ser Phe Asp Lys 
385                 390                 395                 400 

Asp Ile Ile Val Ser Met Trp Thr Gly Gly Trp Gly Gly Tyr Asp Val 
                405                 410                 415     

Ala Ser Ser Lys Leu Leu Ala Glu Lys Gly His Gln Ile Leu Asn Thr 
            420                 425                 430         

Asn Asp Ala Trp Tyr Tyr Val Leu Gly Arg Asn Ala Asp Gly Gln Gly 
        435                 440                 445             

Trp Tyr Asn Leu Asp Gln Gly Leu Asn Gly Ile Lys Asn Thr Pro Ile 
    450                 455                 460                 

Thr Ser Val Pro Lys Thr Glu Gly Ala Asp Ile Pro Ile Ile Gly Gly 
465                 470                 475                 480 

Met Val Ala Ala Trp Ala Asp Thr Pro Ser Ala Arg Tyr Ser Pro Ser 
                485                 490                 495     

Arg Leu Phe Lys Leu Met Arg His Phe Ala Asn Ala Asn Ala Glu Tyr 
            500                 505                 510         

Phe Ala Ala Asp Tyr Glu Ser Ala Glu Gln Ala Leu Asn Glu Val Pro 
        515                 520                 525             

Lys Asp Leu Asn Arg Tyr Thr Ala Glu Ser Val Thr Ala Val Lys Glu 
    530                 535                 540                 

Ala Glu Lys Ala Ile Arg Ser Leu Asp Ser Asn Leu Ser Arg Ala Gln 
545                 550                 555                 560 

Gln Asp Thr Ile Asp Gln Ala Ile Ala Lys Leu Gln Glu Thr Val Asn 
                565                 570                 575     

Asn Leu Thr Leu Thr Pro Glu Ala Gln Lys Glu Glu Glu Ala Lys Arg 
            580                 585                 590         

Glu Val Glu Lys Leu Ala Lys Asn Lys Val Ile Ser Ile Asp Ala Gly 
        595                 600                 605             

Arg Lys Tyr Phe Thr Leu Asn Gln Leu Lys Arg Ile Val Asp Lys Ala 
    610                 615                 620                 

Ser Glu Leu Gly Tyr Ser Asp Val His Leu Leu Leu Gly Asn Asp Gly 
625                 630                 635                 640 

Leu Arg Phe Leu Leu Asp Asp Met Thr Ile Thr Ala Asn Gly Lys Thr 
                645                 650                 655     

Tyr Ala Ser Asp Asp Val Lys Lys Ala Ile Ile Glu Gly Thr Lys Ala 
            660                 665                 670         

Tyr Tyr Asp Asp Pro Asn Gly Thr Ala Leu Thr Gln Ala Glu Val Thr 
        675                 680                 685             

Glu Leu Ile Glu Tyr Ala Lys Ser Lys Asp Ile Gly Leu Ile Pro Ala 
    690                 695                 700                 

Ile Asn Ser Pro Gly His Met Asp Ala Met Leu Val Ala Met Glu Lys 
705                 710                 715                 720 

Leu Gly Ile Lys Asn Pro Gln Ala His Phe Asp Lys Val Ser Lys Thr 
                725                 730                 735     

Thr Met Asp Leu Lys Asn Glu Glu Ala Met Asn Phe Val Lys Ala Leu 
            740                 745                 750         

Ile Gly Lys Tyr Met Asp Phe Phe Ala Gly Lys Thr Lys Ile Phe Asn 
        755                 760                 765             

Phe Gly Thr Asp Glu Tyr Ala Asn Asp Ala Thr Ser Ala Gln Gly Trp 
    770                 775                 780                 

Tyr Tyr Leu Lys Trp Tyr Gln Leu Tyr Gly Lys Phe Ala Glu Tyr Ala 
785                 790                 795                 800 

Asn Thr Leu Ala Ala Met Ala Lys Glu Arg Gly Leu Gln Pro Met Ala 
                805                 810                 815     

Phe Asn Asp Gly Phe Tyr Tyr Glu Asp Lys Asp Asp Val Gln Phe Asp 
            820                 825                 830         

Lys Asp Val Leu Ile Ser Tyr Trp Ser Lys Gly Trp Trp Gly Tyr Asn 
        835                 840                 845             

Leu Ala Ser Pro Gln Tyr Leu Ala Ser Lys Gly Tyr Lys Phe Leu Asn 
    850                 855                 860                 

Thr Asn Gly Asp Trp Tyr Tyr Ile Leu Gly Gln Lys Pro Glu Asp Gly 
865                 870                 875                 880 

Gly Gly Phe Leu Lys Lys Ala Ile Glu Asn Thr Gly Lys Thr Pro Phe 
                885                 890                 895     

Asn Gln Leu Ala Ser Thr Lys Tyr Pro Glu Val Asp Leu Pro Thr Val 
            900                 905                 910         

Gly Ser Met Leu Ser Ile Trp Ala Asp Arg Pro Ser Ala Glu Tyr Lys 
        915                 920                 925             

Glu Glu Glu Ile Phe Glu Leu Met Thr Ala Phe Ala Asp His Asn Lys 
    930                 935                 940                 

Asp Tyr Phe Arg Ala Asn Tyr Asn Ala Leu Arg Glu Glu Leu Ala Lys 
945                 950                 955                 960 

Ile Pro Thr Asn Leu Glu Gly Tyr Ser Lys Glu Ser Leu Glu Ala Leu 
                965                 970                 975     

Asp Ala Ala Lys Thr Ala Leu Asn Tyr Asn Leu Asn Arg Asn Lys Gln 
            980                 985                 990         

Ala Glu Leu Asp Thr Leu Val Ala Asn Leu Lys Ala Ala Leu Gln Gly 
        995                 1000                1005            

Leu Lys Pro Ala Val Thr His Ser Gly Ser Leu Asp Glu Asn Glu Val 
    1010                1015                1020                

Ala Ala Asn Val Glu Thr Arg Pro Glu Leu Ile Thr Arg Thr Glu Glu 
1025                1030                1035                1040

Ile Pro Phe Glu Val Ile Lys Lys Glu Asn Pro Asn Leu Pro Ala Gly 
                1045                1050                1055    

Gln Glu Asn Ile Ile Thr Ala Gly Val Lys Gly Glu Arg Thr His Tyr 
            1060                1065                1070        

Ile Ser Val Leu Thr Glu Asn Gly Lys Thr Thr Glu Thr Val Leu Asp 
        1075                1080                1085            

Ser Gln Val Thr Lys Glu Val Ile Asn Gln Val Val Glu Val Gly Ala 
    1090                1095                1100                

Pro Val Thr His Lys Gly Asp Glu Ser Gly Leu Ala Pro Thr Thr Glu 
1105                1110                1115                1120

Val Lys Pro Arg Leu Asp Ile Gln Glu Glu Glu Ile Pro Phe Thr Thr 
                1125                1130                1135    

Val Thr Cys Glu Asn Pro Leu Leu Leu Lys Gly Lys Thr Gln Val Ile 
            1140                1145                1150        

Thr Lys Gly Val Asn Gly His Arg Ser Asn Phe Tyr Ser Val Ser Thr 
        1155                1160                1165            

Ser Ala Asp Gly Lys Glu Val Lys Thr Leu Val Asn Ser Val Val Ala 
    1170                1175                1180                

Gln Glu Ala Val Thr Gln Ile Val Glu Val Gly Thr Met Val Thr His 
1185                1190                1195                1200

Val Gly Asp Glu Asn Gly Gln Ala Ala Ile Ala Glu Glu Lys Pro Lys 
                1205                1210                1215    

Leu Glu Ile Pro Ser Gln Pro Ala Pro Ser Thr Ala Pro Ala Glu Glu 
            1220                1225                1230        

Ser Lys Val Leu Pro Gln Asp Pro Ala Pro Val Val Thr Glu Lys Lys 
        1235                1240                1245            

Gly Ser Gly Ser Gly Gly Gly Gly Glu Thr Pro Glu Thr Ser Pro Ala 
    1250                1255                1260                

Ile Gly Lys Val Val Ile Lys Glu Thr Gly Glu Gly Gly Ala Leu Leu 
1265                1270                1275                1280

Gly Asp Ala Val Phe Glu Leu Lys Asn Asn Thr Asp Gly Thr Thr Val 
                1285                1290                1295    

Ser Gln Arg Thr Glu Ala Gln Thr Gly Glu Ala Ile Phe Ser Asn Ile 
            1300                1305                1310        

Lys Pro Gly Thr Tyr Thr Leu Thr Glu Ala Gln Pro Pro Val Gly Tyr 
        1315                1320                1325            

Lys Pro Ser Thr Lys Gln Trp Thr Val Glu Val Glu Lys Asn Gly Arg 
    1330                1335                1340                

Thr Thr Val Gln Gly Glu Gln Val Glu Asn Arg Glu Glu Ala Leu Ser 
1345                1350                1355                1360

Asp Gln Tyr Pro Gln Thr Gly Thr Tyr Pro Asp Val Gln Thr Pro Tyr 
                1365                1370                1375    

Gln Ile Ile Lys Val Asp Gly Ser Glu Lys Asn Gly Gln His Lys Ala 
            1380                1385                1390        

Leu Asn Pro Asn Pro Tyr Glu Arg Val Ile Pro Glu Gly Thr Leu Ser 
        1395                1400                1405            

Lys Arg Ile Tyr Gln Val Asn Asn Leu Asp Asp Asn Gln Tyr Gly Ile 
    1410                1415                1420                

Glu Leu Thr Val Ser Gly Lys Thr Val Tyr Glu Gln Lys Asp Lys Ser 
1425                1430                1435                1440

Val Pro Leu Asp Val Val Ile Leu Leu Asp Asn Ser Asn Ser Met Ser 
                1445                1450                1455    

Asn Ile Arg Asn Lys Asn Ala Arg Arg Ala Glu Arg Ala Gly Glu Ala 
            1460                1465                1470        

Thr Arg Ser Leu Ile Asp Lys Ile Thr Ser Asp Ser Glu Asn Arg Val 
        1475                1480                1485            

Ala Leu Val Thr Tyr Ala Ser Thr Ile Phe Asp Gly Thr Glu Phe Thr 
    1490                1495                1500                

Val Glu Lys Gly Val Ala Asp Lys Asn Gly Lys Arg Leu Asn Asp Ser 
1505                1510                1515                1520

Leu Phe Trp Asn Tyr Asp Gln Thr Ser Phe Thr Thr Asn Thr Lys Asp 
                1525                1530                1535    

Tyr Ser Tyr Leu Lys Leu Thr Asn Asp Lys Asn Asp Ile Val Glu Leu 
            1540                1545                1550        

Lys Asn Lys Val Pro Thr Glu Ala Glu Asp His Asp Gly Asn Arg Leu 
        1555                1560                1565            

Met Tyr Gln Phe Gly Ala Thr Phe Thr Gln Lys Ala Leu Met Lys Ala 
    1570                1575                1580                

Asp Glu Ile Leu Thr Gln Gln Ala Arg Gln Asn Ser Gln Lys Val Ile 
1585                1590                1595                1600

Phe His Ile Thr Asp Gly Val Pro Thr Met Ser Tyr Pro Ile Asn Phe 
                1605                1610                1615    

Asn His Ala Thr Phe Ala Pro Ser Tyr Gln Asn Gln Leu Asn Ala Phe 
            1620                1625                1630        

Phe Ser Lys Ser Pro Asn Lys Asp Gly Ile Leu Leu Ser Asp Phe Ile 
        1635                1640                1645            

Thr Gln Ala Thr Ser Gly Glu His Thr Ile Val Arg Gly Asp Gly Gln 
    1650                1655                1660                

Ser Tyr Gln Met Phe Thr Asp Lys Thr Val Tyr Glu Lys Gly Ala Pro 
1665                1670                1675                1680

Ala Ala Phe Pro Val Lys Pro Glu Lys Tyr Ser Glu Met Lys Ala Ala 
                1685                1690                1695    

Gly Tyr Ala Val Ile Gly Asp Pro Ile Asn Gly Gly Tyr Ile Trp Leu 
            1700                1705                1710        

Asn Trp Arg Glu Ser Ile Leu Ala Tyr Pro Phe Asn Ser Asn Thr Ala 
        1715                1720                1725            

Lys Ile Thr Asn His Gly Asp Pro Thr Arg Trp Tyr Tyr Asn Gly Asn 
    1730                1735                1740                

Ile Ala Pro Asp Gly Tyr Asp Val Phe Thr Val Gly Ile Gly Ile Asn 
1745                1750                1755                1760

Gly Asp Pro Gly Thr Asp Glu Ala Thr Ala Thr Ser Phe Met Gln Ser 
                1765                1770                1775    

Ile Ser Ser Lys Pro Glu Asn Tyr Thr Asn Val Thr Asp Thr Thr Lys 
            1780                1785                1790        

Ile Leu Glu Gln Leu Asn Arg Tyr Phe His Thr Ile Val Thr Glu Lys 
        1795                1800                1805            

Lys Ser Ile Glu Asn Gly Thr Ile Thr Asp Pro Met Gly Glu Leu Ile 
    1810                1815                1820                

Asp Leu Gln Leu Gly Thr Asp Gly Arg Phe Asp Pro Ala Asp Tyr Thr 
1825                1830                1835                1840

Leu Thr Ala Asn Asp Gly Ser Arg Leu Glu Asn Gly Gln Ala Val Gly 
                1845                1850                1855    

Gly Pro Gln Asn Asp Gly Gly Leu Leu Lys Asn Ala Lys Val Leu Tyr 
            1860                1865                1870        

Asp Thr Thr Glu Lys Arg Ile Arg Val Thr Gly Leu Tyr Leu Gly Thr 
        1875                1880                1885            

Asp Glu Lys Val Thr Leu Thr Tyr Asn Val Arg Leu Asn Asp Glu Phe 
    1890                1895                1900                

Val Ser Asn Lys Phe Tyr Asp Thr Asn Gly Arg Thr Thr Leu His Pro 
1905                1910                1915                1920

Lys Glu Val Glu Gln Asn Thr Val Arg Asp Phe Pro Ile Pro Lys Ile 
                1925                1930                1935    

Arg Asp Val Arg Lys Tyr Pro Glu Ile Thr Ile Ser Lys Glu Lys Lys 
            1940                1945                1950        

Leu Gly Asp Ile Glu Phe Ile Lys Val Asn Lys Asn Asp Lys Lys Pro 
        1955                1960                1965            

Leu Arg Gly Ala Val Phe Ser Leu Gln Lys Gln His Pro Asp Tyr Pro 
    1970                1975                1980                

Asp Ile Tyr Gly Ala Ile Asp Gln Asn Gly Thr Tyr Gln Asn Val Arg 
1985                1990                1995                2000

Thr Gly Glu Asp Gly Lys Leu Thr Phe Lys Asn Leu Ser Asp Gly Lys 
                2005                2010                2015    

Tyr Arg Leu Phe Glu Asn Ser Glu Pro Ala Gly Tyr Lys Pro Val Gln 
            2020                2025                2030        

Asn Lys Pro Ile Val Ala Phe Gln Ile Val Asn Gly Glu Val Arg Asp 
        2035                2040                2045            

Val Thr Ser Ile Val Pro Gln Asp Ile Pro Ala Gly Tyr Glu Phe Thr 
    2050                2055                2060                

Asn Asp Lys His Tyr Ile Thr Asn Glu Pro Ile Pro Pro Lys Arg Glu 
2065                2070                2075                2080

Leu Glu His His His His His His 
                2085            

<210>   202
<211>   3420
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Hybrid polypeptide

<400>   202
Met Ala Asp Gly Val Thr Pro Thr Thr Thr Glu Asn Gln Pro Thr Ile 
1               5                   10                  15      

His Thr Val Ser Asp Ser Pro Gln Ser Ser Glu Asn Arg Thr Glu Glu 
            20                  25                  30          

Thr Pro Lys Ala Val Leu Gln Pro Glu Ala Pro Lys Thr Val Glu Thr 
        35                  40                  45              

Glu Thr Pro Ala Thr Asp Lys Val Ala Ser Leu Pro Lys Thr Glu Glu 
    50                  55                  60                  

Lys Pro Gln Glu Glu Val Ser Ser Thr Pro Ser Asp Lys Ala Glu Val 
65                  70                  75                  80  

Val Thr Pro Thr Ser Ala Glu Lys Glu Thr Ala Asn Lys Lys Ala Glu 
                85                  90                  95      

Glu Ala Ser Pro Lys Lys Glu Glu Ala Lys Glu Val Asp Ser Lys Glu 
            100                 105                 110         

Ser Asn Thr Asp Lys Thr Asp Lys Asp Lys Pro Ala Lys Lys Asp Glu 
        115                 120                 125             

Ala Lys Ala Glu Ala Asp Lys Pro Ala Thr Glu Ala Gly Lys Glu Arg 
    130                 135                 140                 

Ala Ala Thr Val Asn Glu Lys Leu Ala Lys Lys Lys Ile Val Ser Ile 
145                 150                 155                 160 

Asp Ala Gly Arg Lys Tyr Phe Ser Pro Glu Gln Leu Lys Glu Ile Ile 
                165                 170                 175     

Asp Lys Ala Lys His Tyr Gly Tyr Thr Asp Leu His Leu Leu Val Gly 
            180                 185                 190         

Asn Asp Gly Leu Arg Phe Met Leu Asp Asp Met Ser Ile Thr Ala Asn 
        195                 200                 205             

Gly Lys Thr Tyr Ala Ser Asp Asp Val Lys Arg Ala Ile Glu Lys Gly 
    210                 215                 220                 

Thr Asn Asp Tyr Tyr Asn Asp Pro Asn Gly Asn His Leu Thr Glu Ser 
225                 230                 235                 240 

Gln Met Thr Asp Leu Ile Asn Tyr Ala Lys Asp Lys Gly Ile Gly Leu 
                245                 250                 255     

Ile Pro Thr Val Asn Ser Pro Gly His Met Asp Ala Ile Leu Asn Ala 
            260                 265                 270         

Met Lys Glu Leu Gly Ile Gln Asn Pro Asn Phe Ser Tyr Phe Gly Lys 
        275                 280                 285             

Lys Ser Ala Arg Thr Val Asp Leu Asp Asn Glu Gln Ala Val Ala Phe 
    290                 295                 300                 

Thr Lys Ala Leu Ile Asp Lys Tyr Ala Ala Tyr Phe Ala Lys Lys Thr 
305                 310                 315                 320 

Glu Ile Phe Asn Ile Gly Leu Asp Glu Tyr Ala Asn Asp Ala Thr Asp 
                325                 330                 335     

Ala Lys Gly Trp Ser Val Leu Gln Ala Asp Lys Tyr Tyr Pro Asn Glu 
            340                 345                 350         

Gly Tyr Pro Val Lys Gly Tyr Glu Lys Phe Ile Ala Tyr Ala Asn Asp 
        355                 360                 365             

Leu Ala Arg Ile Val Lys Ser His Gly Leu Lys Pro Met Ala Phe Asn 
    370                 375                 380                 

Asp Gly Ile Tyr Tyr Asn Ser Asp Thr Ser Phe Gly Ser Phe Asp Lys 
385                 390                 395                 400 

Asp Ile Ile Val Ser Met Trp Thr Gly Gly Trp Gly Gly Tyr Asp Val 
                405                 410                 415     

Ala Ser Ser Lys Leu Leu Ala Glu Lys Gly His Gln Ile Leu Asn Thr 
            420                 425                 430         

Asn Asp Ala Trp Tyr Tyr Val Leu Gly Arg Asn Ala Asp Gly Gln Gly 
        435                 440                 445             

Trp Tyr Asn Leu Asp Gln Gly Leu Asn Gly Ile Lys Asn Thr Pro Ile 
    450                 455                 460                 

Thr Ser Val Pro Lys Thr Glu Gly Ala Asp Ile Pro Ile Ile Gly Gly 
465                 470                 475                 480 

Met Val Ala Ala Trp Ala Asp Thr Pro Ser Ala Arg Tyr Ser Pro Ser 
                485                 490                 495     

Arg Leu Phe Lys Leu Met Arg His Phe Ala Asn Ala Asn Ala Glu Tyr 
            500                 505                 510         

Phe Ala Ala Asp Tyr Glu Ser Ala Glu Gln Ala Leu Asn Glu Val Pro 
        515                 520                 525             

Lys Asp Leu Asn Arg Tyr Thr Ala Glu Ser Val Thr Ala Val Lys Glu 
    530                 535                 540                 

Ala Glu Lys Ala Ile Arg Ser Leu Asp Ser Asn Leu Ser Arg Ala Gln 
545                 550                 555                 560 

Gln Asp Thr Ile Asp Gln Ala Ile Ala Lys Leu Gln Glu Thr Val Asn 
                565                 570                 575     

Asn Leu Thr Leu Thr Pro Glu Ala Gln Lys Glu Glu Glu Ala Lys Arg 
            580                 585                 590         

Glu Val Glu Lys Leu Ala Lys Asn Lys Val Ile Ser Ile Asp Ala Gly 
        595                 600                 605             

Arg Lys Tyr Phe Thr Leu Asn Gln Leu Lys Arg Ile Val Asp Lys Ala 
    610                 615                 620                 

Ser Glu Leu Gly Tyr Ser Asp Val His Leu Leu Leu Gly Asn Asp Gly 
625                 630                 635                 640 

Leu Arg Phe Leu Leu Asp Asp Met Thr Ile Thr Ala Asn Gly Lys Thr 
                645                 650                 655     

Tyr Ala Ser Asp Asp Val Lys Lys Ala Ile Ile Glu Gly Thr Lys Ala 
            660                 665                 670         

Tyr Tyr Asp Asp Pro Asn Gly Thr Ala Leu Thr Gln Ala Glu Val Thr 
        675                 680                 685             

Glu Leu Ile Glu Tyr Ala Lys Ser Lys Asp Ile Gly Leu Ile Pro Ala 
    690                 695                 700                 

Ile Asn Ser Pro Gly His Met Asp Ala Met Leu Val Ala Met Glu Lys 
705                 710                 715                 720 

Leu Gly Ile Lys Asn Pro Gln Ala His Phe Asp Lys Val Ser Lys Thr 
                725                 730                 735     

Thr Met Asp Leu Lys Asn Glu Glu Ala Met Asn Phe Val Lys Ala Leu 
            740                 745                 750         

Ile Gly Lys Tyr Met Asp Phe Phe Ala Gly Lys Thr Lys Ile Phe Asn 
        755                 760                 765             

Phe Gly Thr Asp Glu Tyr Ala Asn Asp Ala Thr Ser Ala Gln Gly Trp 
    770                 775                 780                 

Tyr Tyr Leu Lys Trp Tyr Gln Leu Tyr Gly Lys Phe Ala Glu Tyr Ala 
785                 790                 795                 800 

Asn Thr Leu Ala Ala Met Ala Lys Glu Arg Gly Leu Gln Pro Met Ala 
                805                 810                 815     

Phe Asn Asp Gly Phe Tyr Tyr Glu Asp Lys Asp Asp Val Gln Phe Asp 
            820                 825                 830         

Lys Asp Val Leu Ile Ser Tyr Trp Ser Lys Gly Trp Trp Gly Tyr Asn 
        835                 840                 845             

Leu Ala Ser Pro Gln Tyr Leu Ala Ser Lys Gly Tyr Lys Phe Leu Asn 
    850                 855                 860                 

Thr Asn Gly Asp Trp Tyr Tyr Ile Leu Gly Gln Lys Pro Glu Asp Gly 
865                 870                 875                 880 

Gly Gly Phe Leu Lys Lys Ala Ile Glu Asn Thr Gly Lys Thr Pro Phe 
                885                 890                 895     

Asn Gln Leu Ala Ser Thr Lys Tyr Pro Glu Val Asp Leu Pro Thr Val 
            900                 905                 910         

Gly Ser Met Leu Ser Ile Trp Ala Asp Arg Pro Ser Ala Glu Tyr Lys 
        915                 920                 925             

Glu Glu Glu Ile Phe Glu Leu Met Thr Ala Phe Ala Asp His Asn Lys 
    930                 935                 940                 

Asp Tyr Phe Arg Ala Asn Tyr Asn Ala Leu Arg Glu Glu Leu Ala Lys 
945                 950                 955                 960 

Ile Pro Thr Asn Leu Glu Gly Tyr Ser Lys Glu Ser Leu Glu Ala Leu 
                965                 970                 975     

Asp Ala Ala Lys Thr Ala Leu Asn Tyr Asn Leu Asn Arg Asn Lys Gln 
            980                 985                 990         

Ala Glu Leu Asp Thr Leu Val Ala Asn Leu Lys Ala Ala Leu Gln Gly 
        995                 1000                1005            

Leu Lys Pro Ala Val Thr His Ser Gly Ser Leu Asp Glu Asn Glu Val 
    1010                1015                1020                

Ala Ala Asn Val Glu Thr Arg Pro Glu Leu Ile Thr Arg Thr Glu Glu 
1025                1030                1035                1040

Ile Pro Phe Glu Val Ile Lys Lys Glu Asn Pro Asn Leu Pro Ala Gly 
                1045                1050                1055    

Gln Glu Asn Ile Ile Thr Ala Gly Val Lys Gly Glu Arg Thr His Tyr 
            1060                1065                1070        

Ile Ser Val Leu Thr Glu Asn Gly Lys Thr Thr Glu Thr Val Leu Asp 
        1075                1080                1085            

Ser Gln Val Thr Lys Glu Val Ile Asn Gln Val Val Glu Val Gly Ala 
    1090                1095                1100                

Pro Val Thr His Lys Gly Asp Glu Ser Gly Leu Ala Pro Thr Thr Glu 
1105                1110                1115                1120

Val Lys Pro Arg Leu Asp Ile Gln Glu Glu Glu Ile Pro Phe Thr Thr 
                1125                1130                1135    

Val Thr Cys Glu Asn Pro Leu Leu Leu Lys Gly Lys Thr Gln Val Ile 
            1140                1145                1150        

Thr Lys Gly Val Asn Gly His Arg Ser Asn Phe Tyr Ser Val Ser Thr 
        1155                1160                1165            

Ser Ala Asp Gly Lys Glu Val Lys Thr Leu Val Asn Ser Val Val Ala 
    1170                1175                1180                

Gln Glu Ala Val Thr Gln Ile Val Glu Val Gly Thr Met Val Thr His 
1185                1190                1195                1200

Val Gly Asp Glu Asn Gly Gln Ala Ala Ile Ala Glu Glu Lys Pro Lys 
                1205                1210                1215    

Leu Glu Ile Pro Ser Gln Pro Ala Pro Ser Thr Ala Pro Ala Glu Glu 
            1220                1225                1230        

Ser Lys Val Leu Pro Gln Asp Pro Ala Pro Val Val Thr Glu Lys Lys 
        1235                1240                1245            

Gly Ser Gly Ser Gly Gly Gly Gly Asp Glu Thr Leu Ile Thr His Thr 
    1250                1255                1260                

Ala Glu Lys Pro Lys Glu Glu Lys Met Ile Val Glu Glu Lys Ala Asp 
1265                1270                1275                1280

Lys Ala Leu Glu Thr Lys Asn Ile Val Glu Arg Thr Glu Gln Ser Glu 
                1285                1290                1295    

Pro Ser Ser Thr Glu Ala Ile Ala Ser Glu Lys Lys Glu Asp Glu Ala 
            1300                1305                1310        

Val Thr Pro Lys Glu Glu Lys Val Ser Ala Lys Pro Glu Glu Lys Ala 
        1315                1320                1325            

Pro Arg Ile Glu Ser Gln Ala Ser Asn Gln Glu Lys Pro Leu Lys Glu 
    1330                1335                1340                

Asp Ala Lys Ala Val Thr Asn Glu Glu Val Asn Gln Met Ile Glu Asp 
1345                1350                1355                1360

Arg Lys Val Asp Phe Asn Gln Asn Trp Tyr Phe Lys Leu Asn Ala Asn 
                1365                1370                1375    

Ser Lys Glu Ala Ile Lys Pro Asp Ala Asp Val Ser Thr Trp Lys Lys 
            1380                1385                1390        

Leu Asp Leu Pro Tyr Asp Trp Ser Ile Phe Asn Asp Phe Asp His Glu 
        1395                1400                1405            

Ser Pro Ala Gln Asn Glu Gly Gly Gln Leu Asn Gly Gly Glu Ala Trp 
    1410                1415                1420                

Tyr Arg Lys Thr Phe Lys Leu Asp Glu Lys Asp Leu Lys Lys Asn Val 
1425                1430                1435                1440

Arg Leu Thr Phe Asp Gly Val Tyr Met Asp Ser Gln Val Tyr Val Asn 
                1445                1450                1455    

Gly Gln Leu Val Gly His Tyr Pro Asn Gly Tyr Asn Gln Phe Ser Tyr 
            1460                1465                1470        

Asp Ile Thr Lys Tyr Leu Gln Lys Asp Gly Arg Glu Asn Val Ile Ala 
        1475                1480                1485            

Val His Ala Val Asn Lys Gln Pro Ser Ser Arg Trp Tyr Ser Gly Ser 
    1490                1495                1500                

Gly Ile Tyr Arg Asp Val Thr Leu Gln Val Thr Asp Lys Val His Val 
1505                1510                1515                1520

Glu Lys Asn Gly Thr Thr Ile Leu Thr Pro Lys Leu Glu Glu Gln Gln 
                1525                1530                1535    

His Gly Lys Val Glu Thr His Val Thr Ser Lys Ile Val Asn Thr Asp 
            1540                1545                1550        

Asp Lys Asp His Glu Leu Val Ala Glu Tyr Gln Ile Val Glu Arg Gly 
        1555                1560                1565            

Gly His Ala Val Thr Gly Leu Val Arg Thr Ala Ser Arg Thr Leu Lys 
    1570                1575                1580                

Ala His Glu Ser Thr Ser Leu Asp Ala Ile Leu Glu Val Glu Arg Pro 
1585                1590                1595                1600

Lys Leu Trp Thr Val Leu Asn Asp Lys Pro Ala Leu Tyr Glu Leu Ile 
                1605                1610                1615    

Thr Arg Val Tyr Arg Asp Gly Gln Leu Val Asp Ala Lys Lys Asp Leu 
            1620                1625                1630        

Phe Gly Tyr Arg Tyr Tyr His Trp Thr Pro Asn Glu Gly Phe Ser Leu 
        1635                1640                1645            

Asn Gly Glu Arg Ile Lys Phe His Gly Val Ser Leu His His Asp His 
    1650                1655                1660                

Gly Ala Leu Gly Ala Glu Glu Asn Tyr Lys Ala Glu Tyr Arg Arg Leu 
1665                1670                1675                1680

Lys Gln Met Lys Glu Met Gly Val Asn Ser Ile Arg Thr Thr His Asn 
                1685                1690                1695    

Pro Ala Ser Glu Gln Thr Leu Gln Ile Ala Ala Glu Leu Gly Leu Leu 
            1700                1705                1710        

Val Gln Glu Glu Ala Phe Asp Thr Trp Tyr Gly Gly Lys Lys Pro Tyr 
        1715                1720                1725            

Asp Tyr Gly Arg Phe Phe Glu Lys Asp Ala Thr His Pro Glu Ala Arg 
    1730                1735                1740                

Lys Gly Glu Lys Trp Ser Asp Phe Asp Leu Arg Thr Met Val Glu Arg 
1745                1750                1755                1760

Gly Lys Asn Asn Pro Ala Ile Phe Met Trp Ser Ile Gly Asn Glu Ile 
                1765                1770                1775    

Gly Glu Ala Asn Gly Asp Ala His Ser Leu Ala Thr Val Lys Arg Leu 
            1780                1785                1790        

Val Lys Val Ile Lys Asp Val Asp Lys Thr Arg Tyr Val Thr Met Gly 
        1795                1800                1805            

Ala Asp Lys Phe Arg Phe Gly Asn Gly Ser Gly Gly His Glu Lys Ile 
    1810                1815                1820                

Ala Asp Glu Leu Asp Ala Val Gly Phe Asn Tyr Ser Glu Asp Asn Tyr 
1825                1830                1835                1840

Lys Ala Leu Arg Ala Lys His Pro Lys Trp Leu Ile Tyr Gly Ser Glu 
                1845                1850                1855    

Thr Ser Ser Ala Thr Arg Thr Arg Gly Ser Tyr Tyr Arg Pro Glu Arg 
            1860                1865                1870        

Glu Leu Lys His Ser Asn Gly Pro Glu Arg Asn Tyr Glu Gln Ser Asp 
        1875                1880                1885            

Tyr Gly Asn Asp Arg Val Gly Trp Gly Lys Thr Ala Thr Ala Ser Trp 
    1890                1895                1900                

Thr Phe Asp Arg Asp Asn Ala Gly Tyr Ala Gly Gln Phe Ile Trp Thr 
1905                1910                1915                1920

Gly Thr Asp Tyr Ile Gly Glu Pro Thr Pro Trp His Asn Gln Asn Gln 
                1925                1930                1935    

Thr Pro Val Lys Ser Ser Tyr Phe Gly Ile Val Asp Thr Ala Gly Ile 
            1940                1945                1950        

Pro Lys His Asp Phe Tyr Leu Tyr Gln Ser Gln Trp Val Ser Val Lys 
        1955                1960                1965            

Lys Lys Pro Met Val His Leu Leu Pro His Trp Asn Trp Glu Asn Lys 
    1970                1975                1980                

Glu Leu Ala Ser Lys Val Ala Asp Ser Glu Gly Lys Ile Pro Val Arg 
1985                1990                1995                2000

Ala Tyr Ser Asn Ala Ser Ser Val Glu Leu Phe Leu Asn Gly Lys Ser 
                2005                2010                2015    

Leu Gly Leu Lys Thr Phe Asn Lys Lys Gln Thr Ser Asp Gly Arg Thr 
            2020                2025                2030        

Tyr Gln Glu Gly Ala Asn Ala Asn Glu Leu Tyr Leu Glu Trp Lys Val 
        2035                2040                2045            

Ala Tyr Gln Pro Gly Thr Leu Glu Ala Ile Ala Arg Asp Glu Ser Gly 
    2050                2055                2060                

Lys Glu Ile Ala Arg Asp Lys Ile Thr Thr Ala Gly Lys Pro Ala Ala 
2065                2070                2075                2080

Val Arg Leu Ile Lys Glu Asp His Ala Ile Ala Ala Asp Gly Lys Asp 
                2085                2090                2095    

Leu Thr Tyr Ile Tyr Tyr Glu Ile Val Asp Ser Gln Gly Asn Val Val 
            2100                2105                2110        

Pro Thr Ala Asn Asn Leu Val Arg Phe Gln Leu His Gly Gln Gly Gln 
        2115                2120                2125            

Leu Val Gly Val Asp Asn Gly Glu Gln Ala Ser Arg Glu Arg Tyr Lys 
    2130                2135                2140                

Ala Gln Ala Asp Gly Ser Trp Ile Arg Lys Ala Phe Asn Gly Lys Gly 
2145                2150                2155                2160

Val Ala Ile Val Lys Ser Thr Glu Gln Ala Gly Lys Phe Thr Leu Thr 
                2165                2170                2175    

Ala His Ser Asp Leu Leu Lys Ser Asn Gln Val Thr Val Phe Thr Gly 
            2180                2185                2190        

Lys Lys Glu Gly Gln Glu Lys Thr Val Leu Gly Thr Glu Val Pro Lys 
        2195                2200                2205            

Val Gln Thr Ile Ile Gly Glu Ala Pro Glu Met Pro Thr Thr Val Pro 
    2210                2215                2220                

Phe Val Tyr Ser Asp Gly Ser Arg Ala Glu Arg Pro Val Thr Trp Ser 
2225                2230                2235                2240

Ser Val Asp Val Ser Lys Pro Gly Ile Val Thr Val Lys Gly Met Ala 
                2245                2250                2255    

Asp Gly Arg Glu Val Glu Ala Arg Val Glu Val Ile Ala Leu Lys Ser 
            2260                2265                2270        

Glu Leu Pro Val Val Lys Arg Ile Ala Pro Asn Thr Asp Leu Asn Ser 
        2275                2280                2285            

Val Asp Lys Ser Val Ser Tyr Val Leu Ile Asp Gly Ser Val Glu Glu 
    2290                2295                2300                

Tyr Glu Val Asp Lys Trp Glu Ile Ala Glu Glu Asp Lys Ala Lys Leu 
2305                2310                2315                2320

Ala Ile Pro Gly Ser Arg Ile Gln Ala Thr Gly Tyr Leu Glu Gly Gln 
                2325                2330                2335    

Pro Ile His Ala Thr Leu Val Val Glu Glu Gly Asn Pro Ala Ala Pro 
            2340                2345                2350        

Ala Val Pro Thr Val Thr Val Gly Gly Glu Ala Val Thr Gly Leu Thr 
        2355                2360                2365            

Ser Gln Lys Pro Met Gln Tyr Arg Thr Leu Ala Tyr Gly Ala Lys Leu 
    2370                2375                2380                

Pro Glu Val Thr Ala Ser Ala Lys Asn Ala Ala Val Thr Val Leu Gln 
2385                2390                2395                2400

Ala Ser Ala Ala Asn Gly Met Arg Ala Ser Ile Phe Ile Gln Pro Lys 
                2405                2410                2415    

Asp Gly Gly Pro Leu Gln Thr Tyr Ala Ile Gln Phe Leu Glu Glu Ala 
            2420                2425                2430        

Pro Lys Ile Ala His Leu Ser Leu Gln Val Glu Lys Ala Asp Ser Leu 
        2435                2440                2445            

Lys Glu Asp Gln Thr Val Lys Leu Ser Val Arg Ala His Tyr Gln Asp 
    2450                2455                2460                

Gly Thr Gln Ala Val Leu Pro Ala Asp Lys Val Thr Phe Ser Thr Ser 
2465                2470                2475                2480

Gly Glu Gly Glu Val Ala Ile Arg Lys Gly Met Leu Glu Leu His Lys 
                2485                2490                2495    

Pro Gly Ala Val Thr Leu Asn Ala Glu Tyr Glu Gly Ala Lys Asp Gln 
            2500                2505                2510        

Val Glu Leu Thr Ile Gln Ala Asn Thr Glu Lys Lys Ile Ala Gln Ser 
        2515                2520                2525            

Ile Arg Pro Val Asn Val Val Thr Asp Leu His Gln Glu Pro Ser Leu 
    2530                2535                2540                

Pro Ala Thr Val Thr Val Glu Tyr Asp Lys Gly Phe Pro Lys Thr His 
2545                2550                2555                2560

Lys Val Thr Trp Gln Ala Ile Pro Lys Glu Lys Leu Asp Ser Tyr Gln 
                2565                2570                2575    

Thr Phe Glu Val Leu Gly Lys Val Glu Gly Ile Asp Leu Glu Ala Arg 
            2580                2585                2590        

Ala Lys Val Ser Val Glu Gly Ile Val Ser Val Glu Glu Val Ser Val 
        2595                2600                2605            

Thr Thr Pro Ile Ala Glu Ala Pro Gln Leu Pro Glu Ser Val Arg Thr 
    2610                2615                2620                

Tyr Asp Ser Asn Gly His Val Ser Ser Ala Lys Val Ala Trp Asp Ala 
2625                2630                2635                2640

Ile Arg Pro Glu Gln Tyr Ala Lys Glu Gly Val Phe Thr Val Asn Gly 
                2645                2650                2655    

Arg Leu Glu Gly Thr Gln Leu Thr Thr Lys Leu His Val Arg Val Ser 
            2660                2665                2670        

Ala Gln Thr Glu Gln Gly Ala Asn Ile Ser Asp Gln Trp Thr Gly Ser 
        2675                2680                2685            

Glu Leu Pro Leu Ala Phe Ala Ser Asp Ser Asn Pro Ser Asp Pro Val 
    2690                2695                2700                

Ser Asn Val Asn Asp Lys Leu Ile Ser Tyr Asn Asn Gln Pro Ala Asn 
2705                2710                2715                2720

Arg Trp Thr Asn Trp Asn Arg Thr Asn Pro Glu Ala Ser Val Gly Val 
                2725                2730                2735    

Leu Phe Gly Asp Ser Gly Ile Leu Ser Lys Arg Ser Val Asp Asn Leu 
            2740                2745                2750        

Ser Val Gly Phe His Glu Asp His Gly Val Gly Val Pro Lys Ser Tyr 
        2755                2760                2765            

Val Ile Glu Tyr Tyr Val Gly Lys Thr Val Pro Thr Ala Pro Lys Asn 
    2770                2775                2780                

Pro Ser Phe Val Gly Asn Glu Asp His Val Phe Asn Asp Ser Ala Asn 
2785                2790                2795                2800

Trp Lys Pro Val Thr Asn Leu Lys Ala Pro Ala Gln Leu Lys Ala Gly 
                2805                2810                2815    

Glu Met Asn His Phe Ser Phe Asp Lys Val Glu Thr Tyr Ala Val Arg 
            2820                2825                2830        

Ile Arg Met Val Lys Ala Asp Asn Lys Arg Gly Thr Ser Ile Thr Glu 
        2835                2840                2845            

Val Gln Ile Phe Ala Lys Gln Val Ala Ala Ala Lys Gln Gly Gln Thr 
    2850                2855                2860                

Arg Ile Gln Val Asp Gly Lys Asp Leu Ala Asn Phe Asn Pro Asp Leu 
2865                2870                2875                2880

Thr Asp Tyr Tyr Leu Glu Ser Val Asp Gly Lys Val Pro Ala Val Thr 
                2885                2890                2895    

Ala Ser Val Ser Asn Asn Gly Leu Ala Thr Val Val Pro Ser Val Arg 
            2900                2905                2910        

Glu Gly Glu Pro Val Arg Val Ile Ala Lys Ala Glu Asn Gly Asp Ile 
        2915                2920                2925            

Leu Gly Glu Tyr Arg Leu His Phe Thr Lys Asp Lys Ser Leu Leu Ser 
    2930                2935                2940                

His Lys Pro Val Ala Ala Val Lys Gln Ala Arg Leu Leu Gln Val Gly 
2945                2950                2955                2960

Gln Ala Leu Glu Leu Pro Thr Lys Val Pro Val Tyr Phe Thr Gly Lys 
                2965                2970                2975    

Asp Gly Tyr Glu Thr Lys Asp Leu Thr Val Glu Trp Glu Glu Val Pro 
            2980                2985                2990        

Ala Glu Asn Leu Thr Lys Ala Gly Gln Phe Thr Val Arg Gly Arg Val 
        2995                3000                3005            

Leu Gly Ser Asn Leu Val Ala Glu Ile Thr Val Arg Val Thr Asp Lys 
    3010                3015                3020                

Leu Gly Glu Thr Leu Ser Asp Asn Pro Asn Tyr Asp Glu Asn Ser Asn 
3025                3030                3035                3040

Gln Ala Phe Ala Ser Ala Thr Asn Asp Ile Asp Lys Asn Ser His Asp 
                3045                3050                3055    

Arg Val Asp Tyr Leu Asn Asp Gly Asp His Ser Glu Asn Arg Arg Trp 
            3060                3065                3070        

Thr Asn Trp Ser Pro Thr Pro Ser Ser Asn Pro Glu Val Ser Ala Gly 
        3075                3080                3085            

Val Ile Phe Arg Glu Asn Gly Lys Ile Val Glu Arg Thr Val Thr Gln 
    3090                3095                3100                

Gly Lys Val Gln Phe Phe Ala Asp Ser Gly Thr Asp Ala Pro Ser Lys 
3105                3110                3115                3120

Leu Val Leu Glu Arg Tyr Val Gly Pro Glu Phe Glu Val Pro Thr Tyr 
                3125                3130                3135    

Tyr Ser Asn Tyr Gln Ala Tyr Asp Ala Asp His Pro Phe Asn Asn Pro 
            3140                3145                3150        

Glu Asn Trp Glu Ala Val Pro Tyr Arg Ala Asp Lys Asp Ile Ala Ala 
        3155                3160                3165            

Gly Asp Glu Ile Asn Val Thr Phe Lys Ala Ile Lys Ala Lys Ala Met 
    3170                3175                3180                

Arg Trp Arg Met Glu Arg Lys Ala Asp Lys Ser Gly Val Ala Met Ile 
3185                3190                3195                3200

Glu Met Thr Phe Leu Ala Pro Ser Glu Leu Pro Gln Glu Ser Thr Gln 
                3205                3210                3215    

Ser Lys Ile Leu Val Asp Gly Lys Glu Leu Ala Asp Phe Ala Glu Asn 
            3220                3225                3230        

Arg Gln Asp Tyr Gln Ile Thr Tyr Lys Gly Gln Arg Pro Lys Val Ser 
        3235                3240                3245            

Val Glu Glu Asn Asn Gln Val Ala Ser Thr Val Val Asp Ser Gly Glu 
    3250                3255                3260                

Asp Ser Phe Pro Val Leu Val Arg Leu Val Ser Glu Ser Gly Lys Gln 
3265                3270                3275                3280

Val Lys Glu Tyr Arg Ile His Leu Thr Lys Glu Lys Pro Val Ser Glu 
                3285                3290                3295    

Lys Thr Val Ala Ala Val Gln Glu Asp Leu Pro Lys Ile Glu Phe Val 
            3300                3305                3310        

Glu Lys Asp Leu Ala Tyr Lys Thr Val Glu Lys Lys Asp Ser Thr Leu 
        3315                3320                3325            

Tyr Leu Gly Glu Thr Arg Val Glu Gln Glu Gly Lys Val Gly Lys Glu 
    3330                3335                3340                

Arg Ile Phe Thr Ala Ile Asn Pro Asp Gly Ser Lys Glu Glu Lys Leu 
3345                3350                3355                3360

Arg Glu Val Val Glu Val Pro Thr Asp Arg Ile Val Leu Val Gly Thr 
                3365                3370                3375    

Lys Pro Val Ala Gln Glu Ala Lys Lys Pro Gln Val Ser Glu Lys Ala 
            3380                3385                3390        

Asp Thr Lys Pro Ile Asp Ser Ser Glu Ala Ser Gln Thr Asn Lys Ala 
        3395                3400                3405            

Gln Ala Ala Ala Leu Glu His His His His His His 
    3410                3415                3420

<210>   203
<211>   2330
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Hybrid polypeptide

<400>   203
Met Ala Asp Gly Val Thr Pro Thr Thr Thr Glu Asn Gln Pro Thr Ile 
1               5                   10                  15      

His Thr Val Ser Asp Ser Pro Gln Ser Ser Glu Asn Arg Thr Glu Glu 
            20                  25                  30          

Thr Pro Lys Ala Val Leu Gln Pro Glu Ala Pro Lys Thr Val Glu Thr 
        35                  40                  45              

Glu Thr Pro Ala Thr Asp Lys Val Ala Ser Leu Pro Lys Thr Glu Glu 
    50                  55                  60                  

Lys Pro Gln Glu Glu Val Ser Ser Thr Pro Ser Asp Lys Ala Glu Val 
65                  70                  75                  80  

Val Thr Pro Thr Ser Ala Glu Lys Glu Thr Ala Asn Lys Lys Ala Glu 
                85                  90                  95      

Glu Ala Ser Pro Lys Lys Glu Glu Ala Lys Glu Val Asp Ser Lys Glu 
            100                 105                 110         

Ser Asn Thr Asp Lys Thr Asp Lys Asp Lys Pro Ala Lys Lys Asp Glu 
        115                 120                 125             

Ala Lys Ala Glu Ala Asp Lys Pro Ala Thr Glu Ala Gly Lys Glu Arg 
    130                 135                 140                 

Ala Ala Thr Val Asn Glu Lys Leu Ala Lys Lys Lys Ile Val Ser Ile 
145                 150                 155                 160 

Asp Ala Gly Arg Lys Tyr Phe Ser Pro Glu Gln Leu Lys Glu Ile Ile 
                165                 170                 175     

Asp Lys Ala Lys His Tyr Gly Tyr Thr Asp Leu His Leu Leu Val Gly 
            180                 185                 190         

Asn Asp Gly Leu Arg Phe Met Leu Asp Asp Met Ser Ile Thr Ala Asn 
        195                 200                 205             

Gly Lys Thr Tyr Ala Ser Asp Asp Val Lys Arg Ala Ile Glu Lys Gly 
    210                 215                 220                 

Thr Asn Asp Tyr Tyr Asn Asp Pro Asn Gly Asn His Leu Thr Glu Ser 
225                 230                 235                 240 

Gln Met Thr Asp Leu Ile Asn Tyr Ala Lys Asp Lys Gly Ile Gly Leu 
                245                 250                 255     

Ile Pro Thr Val Asn Ser Pro Gly His Met Asp Ala Ile Leu Asn Ala 
            260                 265                 270         

Met Lys Glu Leu Gly Ile Gln Asn Pro Asn Phe Ser Tyr Phe Gly Lys 
        275                 280                 285             

Lys Ser Ala Arg Thr Val Asp Leu Asp Asn Glu Gln Ala Val Ala Phe 
    290                 295                 300                 

Thr Lys Ala Leu Ile Asp Lys Tyr Ala Ala Tyr Phe Ala Lys Lys Thr 
305                 310                 315                 320 

Glu Ile Phe Asn Ile Gly Leu Asp Glu Tyr Ala Asn Asp Ala Thr Asp 
                325                 330                 335     

Ala Lys Gly Trp Ser Val Leu Gln Ala Asp Lys Tyr Tyr Pro Asn Glu 
            340                 345                 350         

Gly Tyr Pro Val Lys Gly Tyr Glu Lys Phe Ile Ala Tyr Ala Asn Asp 
        355                 360                 365             

Leu Ala Arg Ile Val Lys Ser His Gly Leu Lys Pro Met Ala Phe Asn 
    370                 375                 380                 

Asp Gly Ile Tyr Tyr Asn Ser Asp Thr Ser Phe Gly Ser Phe Asp Lys 
385                 390                 395                 400 

Asp Ile Ile Val Ser Met Trp Thr Gly Gly Trp Gly Gly Tyr Asp Val 
                405                 410                 415     

Ala Ser Ser Lys Leu Leu Ala Glu Lys Gly His Gln Ile Leu Asn Thr 
            420                 425                 430         

Asn Asp Ala Trp Tyr Tyr Val Leu Gly Arg Asn Ala Asp Gly Gln Gly 
        435                 440                 445             

Trp Tyr Asn Leu Asp Gln Gly Leu Asn Gly Ile Lys Asn Thr Pro Ile 
    450                 455                 460                 

Thr Ser Val Pro Lys Thr Glu Gly Ala Asp Ile Pro Ile Ile Gly Gly 
465                 470                 475                 480 

Met Val Ala Ala Trp Ala Asp Thr Pro Ser Ala Arg Tyr Ser Pro Ser 
                485                 490                 495     

Arg Leu Phe Lys Leu Met Arg His Phe Ala Asn Ala Asn Ala Glu Tyr 
            500                 505                 510         

Phe Ala Ala Asp Tyr Glu Ser Ala Glu Gln Ala Leu Asn Glu Val Pro 
        515                 520                 525             

Lys Asp Leu Asn Arg Tyr Thr Ala Glu Ser Val Thr Ala Val Lys Glu 
    530                 535                 540                 

Ala Glu Lys Ala Ile Arg Ser Leu Asp Ser Asn Leu Ser Arg Ala Gln 
545                 550                 555                 560 

Gln Asp Thr Ile Asp Gln Ala Ile Ala Lys Leu Gln Glu Thr Val Asn 
                565                 570                 575     

Asn Leu Thr Leu Thr Pro Glu Ala Gln Lys Glu Glu Glu Ala Lys Arg 
            580                 585                 590         

Glu Val Glu Lys Leu Ala Lys Asn Lys Val Ile Ser Ile Asp Ala Gly 
        595                 600                 605             

Arg Lys Tyr Phe Thr Leu Asn Gln Leu Lys Arg Ile Val Asp Lys Ala 
    610                 615                 620                 

Ser Glu Leu Gly Tyr Ser Asp Val His Leu Leu Leu Gly Asn Asp Gly 
625                 630                 635                 640 

Leu Arg Phe Leu Leu Asp Asp Met Thr Ile Thr Ala Asn Gly Lys Thr 
                645                 650                 655     

Tyr Ala Ser Asp Asp Val Lys Lys Ala Ile Ile Glu Gly Thr Lys Ala 
            660                 665                 670         

Tyr Tyr Asp Asp Pro Asn Gly Thr Ala Leu Thr Gln Ala Glu Val Thr 
        675                 680                 685             

Glu Leu Ile Glu Tyr Ala Lys Ser Lys Asp Ile Gly Leu Ile Pro Ala 
    690                 695                 700                 

Ile Asn Ser Pro Gly His Met Asp Ala Met Leu Val Ala Met Glu Lys 
705                 710                 715                 720 

Leu Gly Ile Lys Asn Pro Gln Ala His Phe Asp Lys Val Ser Lys Thr 
                725                 730                 735     

Thr Met Asp Leu Lys Asn Glu Glu Ala Met Asn Phe Val Lys Ala Leu 
            740                 745                 750         

Ile Gly Lys Tyr Met Asp Phe Phe Ala Gly Lys Thr Lys Ile Phe Asn 
        755                 760                 765             

Phe Gly Thr Asp Glu Tyr Ala Asn Asp Ala Thr Ser Ala Gln Gly Trp 
    770                 775                 780                 

Tyr Tyr Leu Lys Trp Tyr Gln Leu Tyr Gly Lys Phe Ala Glu Tyr Ala 
785                 790                 795                 800 

Asn Thr Leu Ala Ala Met Ala Lys Glu Arg Gly Leu Gln Pro Met Ala 
                805                 810                 815     

Phe Asn Asp Gly Phe Tyr Tyr Glu Asp Lys Asp Asp Val Gln Phe Asp 
            820                 825                 830         

Lys Asp Val Leu Ile Ser Tyr Trp Ser Lys Gly Trp Trp Gly Tyr Asn 
        835                 840                 845             

Leu Ala Ser Pro Gln Tyr Leu Ala Ser Lys Gly Tyr Lys Phe Leu Asn 
    850                 855                 860                 

Thr Asn Gly Asp Trp Tyr Tyr Ile Leu Gly Gln Lys Pro Glu Asp Gly 
865                 870                 875                 880 

Gly Gly Phe Leu Lys Lys Ala Ile Glu Asn Thr Gly Lys Thr Pro Phe 
                885                 890                 895     

Asn Gln Leu Ala Ser Thr Lys Tyr Pro Glu Val Asp Leu Pro Thr Val 
            900                 905                 910         

Gly Ser Met Leu Ser Ile Trp Ala Asp Arg Pro Ser Ala Glu Tyr Lys 
        915                 920                 925             

Glu Glu Glu Ile Phe Glu Leu Met Thr Ala Phe Ala Asp His Asn Lys 
    930                 935                 940                 

Asp Tyr Phe Arg Ala Asn Tyr Asn Ala Leu Arg Glu Glu Leu Ala Lys 
945                 950                 955                 960 

Ile Pro Thr Asn Leu Glu Gly Tyr Ser Lys Glu Ser Leu Glu Ala Leu 
                965                 970                 975     

Asp Ala Ala Lys Thr Ala Leu Asn Tyr Asn Leu Asn Arg Asn Lys Gln 
            980                 985                 990         

Ala Glu Leu Asp Thr Leu Val Ala Asn Leu Lys Ala Ala Leu Gln Gly 
        995                 1000                1005            

Leu Lys Pro Ala Val Thr His Ser Gly Ser Leu Asp Glu Asn Glu Val 
    1010                1015                1020                

Ala Ala Asn Val Glu Thr Arg Pro Glu Leu Ile Thr Arg Thr Glu Glu 
1025                1030                1035                1040

Ile Pro Phe Glu Val Ile Lys Lys Glu Asn Pro Asn Leu Pro Ala Gly 
                1045                1050                1055    

Gln Glu Asn Ile Ile Thr Ala Gly Val Lys Gly Glu Arg Thr His Tyr 
            1060                1065                1070        

Ile Ser Val Leu Thr Glu Asn Gly Lys Thr Thr Glu Thr Val Leu Asp 
        1075                1080                1085            

Ser Gln Val Thr Lys Glu Val Ile Asn Gln Val Val Glu Val Gly Ala 
    1090                1095                1100                

Pro Val Thr His Lys Gly Asp Glu Ser Gly Leu Ala Pro Thr Thr Glu 
1105                1110                1115                1120

Val Lys Pro Arg Leu Asp Ile Gln Glu Glu Glu Ile Pro Phe Thr Thr 
                1125                1130                1135    

Val Thr Cys Glu Asn Pro Leu Leu Leu Lys Gly Lys Thr Gln Val Ile 
            1140                1145                1150        

Thr Lys Gly Val Asn Gly His Arg Ser Asn Phe Tyr Ser Val Ser Thr 
        1155                1160                1165            

Ser Ala Asp Gly Lys Glu Val Lys Thr Leu Val Asn Ser Val Val Ala 
    1170                1175                1180                

Gln Glu Ala Val Thr Gln Ile Val Glu Val Gly Thr Met Val Thr His 
1185                1190                1195                1200

Val Gly Asp Glu Asn Gly Gln Ala Ala Ile Ala Glu Glu Lys Pro Lys 
                1205                1210                1215    

Leu Glu Ile Pro Ser Gln Pro Ala Pro Ser Thr Ala Pro Ala Glu Glu 
            1220                1225                1230        

Ser Lys Val Leu Pro Gln Asp Pro Ala Pro Val Val Thr Glu Lys Lys 
        1235                1240                1245            

Gly Ser Gly Ser Gly Gly Gly Gly Asp Glu Thr Leu Ile Thr His Thr 
    1250                1255                1260                

Ala Glu Lys Pro Lys Glu Glu Lys Met Ile Val Glu Glu Lys Ala Asp 
1265                1270                1275                1280

Lys Ala Leu Glu Thr Lys Asn Ile Val Glu Arg Thr Glu Gln Ser Glu 
                1285                1290                1295    

Pro Ser Ser Thr Glu Ala Ile Ala Ser Glu Lys Lys Glu Asp Glu Ala 
            1300                1305                1310        

Val Thr Pro Lys Glu Glu Lys Val Ser Ala Lys Pro Glu Glu Lys Ala 
        1315                1320                1325            

Pro Arg Ile Glu Ser Gln Ala Ser Asn Gln Glu Lys Pro Leu Lys Glu 
    1330                1335                1340                

Asp Ala Lys Ala Val Thr Asn Glu Glu Val Asn Gln Met Ile Glu Asp 
1345                1350                1355                1360

Arg Lys Val Asp Phe Asn Gln Asn Trp Tyr Phe Lys Leu Asn Ala Asn 
                1365                1370                1375    

Ser Lys Glu Ala Ile Lys Pro Asp Ala Asp Val Ser Thr Trp Lys Lys 
            1380                1385                1390        

Leu Asp Leu Pro Tyr Asp Trp Ser Ile Phe Asn Asp Phe Asp His Glu 
        1395                1400                1405            

Ser Pro Ala Gln Asn Glu Gly Gly Gln Leu Asn Gly Gly Glu Ala Trp 
    1410                1415                1420                

Tyr Arg Lys Thr Phe Lys Leu Asp Glu Lys Asp Leu Lys Lys Asn Val 
1425                1430                1435                1440

Arg Leu Thr Phe Asp Gly Val Tyr Met Asp Ser Gln Val Tyr Val Asn 
                1445                1450                1455    

Gly Gln Leu Val Gly His Tyr Pro Asn Gly Tyr Asn Gln Phe Ser Tyr 
            1460                1465                1470        

Asp Ile Thr Lys Tyr Leu Gln Lys Asp Gly Arg Glu Asn Val Ile Ala 
        1475                1480                1485            

Val His Ala Val Asn Lys Gln Pro Ser Ser Arg Trp Tyr Ser Gly Ser 
    1490                1495                1500                

Gly Ile Tyr Arg Asp Val Thr Leu Gln Val Thr Asp Lys Val His Val 
1505                1510                1515                1520

Glu Lys Asn Gly Thr Thr Ile Leu Thr Pro Lys Leu Glu Glu Gln Gln 
                1525                1530                1535    

His Gly Lys Val Glu Thr His Val Thr Ser Lys Ile Val Asn Thr Asp 
            1540                1545                1550        

Asp Lys Asp His Glu Leu Val Ala Glu Tyr Gln Ile Val Glu Arg Gly 
        1555                1560                1565            

Gly His Ala Val Thr Gly Leu Val Arg Thr Ala Ser Arg Thr Leu Lys 
    1570                1575                1580                

Ala His Glu Ser Thr Ser Leu Asp Ala Ile Leu Glu Val Glu Arg Pro 
1585                1590                1595                1600

Lys Leu Trp Thr Val Leu Asn Asp Lys Pro Ala Leu Tyr Glu Leu Ile 
                1605                1610                1615    

Thr Arg Val Tyr Arg Asp Gly Gln Leu Val Asp Ala Lys Lys Asp Leu 
            1620                1625                1630        

Phe Gly Tyr Arg Tyr Tyr His Trp Thr Pro Asn Glu Gly Phe Ser Leu 
        1635                1640                1645            

Asn Gly Glu Arg Ile Lys Phe His Gly Val Ser Leu His His Asp His 
    1650                1655                1660                

Gly Ala Leu Gly Ala Glu Glu Asn Tyr Lys Ala Glu Tyr Arg Arg Leu 
1665                1670                1675                1680

Lys Gln Met Lys Glu Met Gly Val Asn Ser Ile Arg Thr Thr His Asn 
                1685                1690                1695    

Pro Ala Ser Glu Gln Thr Leu Gln Ile Ala Ala Glu Leu Gly Leu Leu 
            1700                1705                1710        

Val Gln Glu Glu Ala Phe Asp Thr Trp Tyr Gly Gly Lys Lys Pro Tyr 
        1715                1720                1725            

Asp Tyr Gly Arg Phe Phe Glu Lys Asp Ala Thr His Pro Glu Ala Arg 
    1730                1735                1740                

Lys Gly Glu Lys Trp Ser Asp Phe Asp Leu Arg Thr Met Val Glu Arg 
1745                1750                1755                1760

Gly Lys Asn Asn Pro Ala Ile Phe Met Trp Ser Ile Gly Asn Glu Ile 
                1765                1770                1775    

Gly Glu Ala Asn Gly Asp Ala His Ser Leu Ala Thr Val Lys Arg Leu 
            1780                1785                1790        

Val Lys Val Ile Lys Asp Val Asp Lys Thr Arg Tyr Val Thr Met Gly 
        1795                1800                1805            

Ala Asp Lys Phe Arg Phe Gly Asn Gly Ser Gly Gly His Glu Lys Ile 
    1810                1815                1820                

Ala Asp Glu Leu Asp Ala Val Gly Phe Asn Tyr Ser Glu Asp Asn Tyr 
1825                1830                1835                1840

Lys Ala Leu Arg Ala Lys His Pro Lys Trp Leu Ile Tyr Gly Ser Glu 
                1845                1850                1855    

Thr Ser Ser Ala Thr Arg Thr Arg Gly Ser Tyr Tyr Arg Pro Glu Arg 
            1860                1865                1870        

Glu Leu Lys His Ser Asn Gly Pro Glu Arg Asn Tyr Glu Gln Ser Asp 
        1875                1880                1885            

Tyr Gly Asn Asp Arg Val Gly Trp Gly Lys Thr Ala Thr Ala Ser Trp 
    1890                1895                1900                

Thr Phe Asp Arg Asp Asn Ala Gly Tyr Ala Gly Gln Phe Ile Trp Thr 
1905                1910                1915                1920

Gly Thr Asp Tyr Ile Gly Glu Pro Thr Pro Trp His Asn Gln Asn Gln 
                1925                1930                1935    

Thr Pro Val Lys Ser Ser Tyr Phe Gly Ile Val Asp Thr Ala Gly Ile 
            1940                1945                1950        

Pro Lys His Asp Phe Tyr Leu Tyr Gln Ser Gln Trp Val Ser Val Lys 
        1955                1960                1965            

Lys Lys Pro Met Val His Leu Leu Pro His Trp Asn Trp Glu Asn Lys 
    1970                1975                1980                

Glu Leu Ala Ser Lys Val Ala Asp Ser Glu Gly Lys Ile Pro Val Arg 
1985                1990                1995                2000

Ala Tyr Ser Asn Ala Ser Ser Val Glu Leu Phe Leu Asn Gly Lys Ser 
                2005                2010                2015    

Leu Gly Leu Lys Thr Phe Asn Lys Lys Gln Thr Ser Asp Gly Arg Thr 
            2020                2025                2030        

Tyr Gln Glu Gly Ala Asn Ala Asn Glu Leu Tyr Leu Glu Trp Lys Val 
        2035                2040                2045            

Ala Tyr Gln Pro Gly Thr Leu Glu Ala Ile Ala Arg Asp Glu Ser Gly 
    2050                2055                2060                

Lys Glu Ile Ala Arg Asp Lys Ile Thr Thr Ala Gly Lys Pro Ala Ala 
2065                2070                2075                2080

Val Arg Leu Ile Lys Glu Asp His Ala Ile Ala Ala Asp Gly Lys Asp 
                2085                2090                2095    

Leu Thr Tyr Ile Tyr Tyr Glu Ile Val Asp Ser Gln Gly Asn Val Val 
            2100                2105                2110        

Pro Thr Ala Asn Asn Leu Val Arg Phe Gln Leu His Gly Gln Gly Gln 
        2115                2120                2125            

Leu Val Gly Val Asp Asn Gly Glu Gln Ala Ser Arg Glu Arg Tyr Lys 
    2130                2135                2140                

Ala Gln Ala Asp Gly Ser Trp Ile Arg Lys Ala Phe Asn Gly Lys Gly 
2145                2150                2155                2160

Val Ala Ile Val Lys Ser Thr Glu Gln Ala Gly Lys Phe Thr Leu Thr 
                2165                2170                2175    

Ala His Ser Asp Leu Leu Lys Ser Asn Gln Val Thr Val Phe Thr Gly 
            2180                2185                2190        

Lys Lys Glu Gly Gln Glu Lys Thr Val Leu Gly Thr Glu Val Pro Lys 
        2195                2200                2205            

Val Gln Thr Ile Ile Gly Glu Ala Pro Glu Met Pro Thr Thr Val Pro 
    2210                2215                2220                

Phe Val Tyr Ser Asp Gly Ser Arg Ala Glu Arg Pro Val Thr Trp Ser 
2225                2230                2235                2240

Ser Val Asp Val Ser Lys Pro Gly Ile Val Thr Val Lys Gly Met Ala 
                2245                2250                2255    

Asp Gly Arg Glu Val Glu Ala Arg Val Glu Val Ile Ala Leu Lys Ser 
            2260                2265                2270        

Glu Leu Pro Val Val Lys Arg Ile Ala Pro Asn Thr Asp Leu Asn Ser 
        2275                2280                2285            

Val Asp Lys Ser Val Ser Tyr Val Leu Ile Asp Gly Ser Val Glu Glu 
    2290                2295                2300                

Tyr Glu Val Asp Lys Trp Glu Ile Ala Glu Glu Asp Lys Ala Lys Ala 
2305                2310                2315                2320

Ala Ala Leu Glu His His His His His His 
                2325                2330

<210>   204
<211>   2365
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Hybrid polypeptide

<400>   204
Met Ala Asp Gly Val Thr Pro Thr Thr Thr Glu Asn Gln Pro Thr Ile 
1               5                   10                  15      

His Thr Val Ser Asp Ser Pro Gln Ser Ser Glu Asn Arg Thr Glu Glu 
            20                  25                  30          

Thr Pro Lys Ala Val Leu Gln Pro Glu Ala Pro Lys Thr Val Glu Thr 
        35                  40                  45              

Glu Thr Pro Ala Thr Asp Lys Val Ala Ser Leu Pro Lys Thr Glu Glu 
    50                  55                  60                  

Lys Pro Gln Glu Glu Val Ser Ser Thr Pro Ser Asp Lys Ala Glu Val 
65                  70                  75                  80  

Val Thr Pro Thr Ser Ala Glu Lys Glu Thr Ala Asn Lys Lys Ala Glu 
                85                  90                  95      

Glu Ala Ser Pro Lys Lys Glu Glu Ala Lys Glu Val Asp Ser Lys Glu 
            100                 105                 110         

Ser Asn Thr Asp Lys Thr Asp Lys Asp Lys Pro Ala Lys Lys Asp Glu 
        115                 120                 125             

Ala Lys Ala Glu Ala Asp Lys Pro Ala Thr Glu Ala Gly Lys Glu Arg 
    130                 135                 140                 

Ala Ala Thr Val Asn Glu Lys Leu Ala Lys Lys Lys Ile Val Ser Ile 
145                 150                 155                 160 

Asp Ala Gly Arg Lys Tyr Phe Ser Pro Glu Gln Leu Lys Glu Ile Ile 
                165                 170                 175     

Asp Lys Ala Lys His Tyr Gly Tyr Thr Asp Leu His Leu Leu Val Gly 
            180                 185                 190         

Asn Asp Gly Leu Arg Phe Met Leu Asp Asp Met Ser Ile Thr Ala Asn 
        195                 200                 205             

Gly Lys Thr Tyr Ala Ser Asp Asp Val Lys Arg Ala Ile Glu Lys Gly 
    210                 215                 220                 

Thr Asn Asp Tyr Tyr Asn Asp Pro Asn Gly Asn His Leu Thr Glu Ser 
225                 230                 235                 240 

Gln Met Thr Asp Leu Ile Asn Tyr Ala Lys Asp Lys Gly Ile Gly Leu 
                245                 250                 255     

Ile Pro Thr Val Asn Ser Pro Gly His Met Asp Ala Ile Leu Asn Ala 
            260                 265                 270         

Met Lys Glu Leu Gly Ile Gln Asn Pro Asn Phe Ser Tyr Phe Gly Lys 
        275                 280                 285             

Lys Ser Ala Arg Thr Val Asp Leu Asp Asn Glu Gln Ala Val Ala Phe 
    290                 295                 300                 

Thr Lys Ala Leu Ile Asp Lys Tyr Ala Ala Tyr Phe Ala Lys Lys Thr 
305                 310                 315                 320 

Glu Ile Phe Asn Ile Gly Leu Asp Glu Tyr Ala Asn Asp Ala Thr Asp 
                325                 330                 335     

Ala Lys Gly Trp Ser Val Leu Gln Ala Asp Lys Tyr Tyr Pro Asn Glu 
            340                 345                 350         

Gly Tyr Pro Val Lys Gly Tyr Glu Lys Phe Ile Ala Tyr Ala Asn Asp 
        355                 360                 365             

Leu Ala Arg Ile Val Lys Ser His Gly Leu Lys Pro Met Ala Phe Asn 
    370                 375                 380                 

Asp Gly Ile Tyr Tyr Asn Ser Asp Thr Ser Phe Gly Ser Phe Asp Lys 
385                 390                 395                 400 

Asp Ile Ile Val Ser Met Trp Thr Gly Gly Trp Gly Gly Tyr Asp Val 
                405                 410                 415     

Ala Ser Ser Lys Leu Leu Ala Glu Lys Gly His Gln Ile Leu Asn Thr 
            420                 425                 430         

Asn Asp Ala Trp Tyr Tyr Val Leu Gly Arg Asn Ala Asp Gly Gln Gly 
        435                 440                 445             

Trp Tyr Asn Leu Asp Gln Gly Leu Asn Gly Ile Lys Asn Thr Pro Ile 
    450                 455                 460                 

Thr Ser Val Pro Lys Thr Glu Gly Ala Asp Ile Pro Ile Ile Gly Gly 
465                 470                 475                 480 

Met Val Ala Ala Trp Ala Asp Thr Pro Ser Ala Arg Tyr Ser Pro Ser 
                485                 490                 495     

Arg Leu Phe Lys Leu Met Arg His Phe Ala Asn Ala Asn Ala Glu Tyr 
            500                 505                 510         

Phe Ala Ala Asp Tyr Glu Ser Ala Glu Gln Ala Leu Asn Glu Val Pro 
        515                 520                 525             

Lys Asp Leu Asn Arg Tyr Thr Ala Glu Ser Val Thr Ala Val Lys Glu 
    530                 535                 540                 

Ala Glu Lys Ala Ile Arg Ser Leu Asp Ser Asn Leu Ser Arg Ala Gln 
545                 550                 555                 560 

Gln Asp Thr Ile Asp Gln Ala Ile Ala Lys Leu Gln Glu Thr Val Asn 
                565                 570                 575     

Asn Leu Thr Leu Thr Pro Glu Ala Gln Lys Glu Glu Glu Ala Lys Arg 
            580                 585                 590         

Glu Val Glu Lys Leu Ala Lys Asn Lys Val Ile Ser Ile Asp Ala Gly 
        595                 600                 605             

Arg Lys Tyr Phe Thr Leu Asn Gln Leu Lys Arg Ile Val Asp Lys Ala 
    610                 615                 620                 

Ser Glu Leu Gly Tyr Ser Asp Val His Leu Leu Leu Gly Asn Asp Gly 
625                 630                 635                 640 

Leu Arg Phe Leu Leu Asp Asp Met Thr Ile Thr Ala Asn Gly Lys Thr 
                645                 650                 655     

Tyr Ala Ser Asp Asp Val Lys Lys Ala Ile Ile Glu Gly Thr Lys Ala 
            660                 665                 670         

Tyr Tyr Asp Asp Pro Asn Gly Thr Ala Leu Thr Gln Ala Glu Val Thr 
        675                 680                 685             

Glu Leu Ile Glu Tyr Ala Lys Ser Lys Asp Ile Gly Leu Ile Pro Ala 
    690                 695                 700                 

Ile Asn Ser Pro Gly His Met Asp Ala Met Leu Val Ala Met Glu Lys 
705                 710                 715                 720 

Leu Gly Ile Lys Asn Pro Gln Ala His Phe Asp Lys Val Ser Lys Thr 
                725                 730                 735     

Thr Met Asp Leu Lys Asn Glu Glu Ala Met Asn Phe Val Lys Ala Leu 
            740                 745                 750         

Ile Gly Lys Tyr Met Asp Phe Phe Ala Gly Lys Thr Lys Ile Phe Asn 
        755                 760                 765             

Phe Gly Thr Asp Glu Tyr Ala Asn Asp Ala Thr Ser Ala Gln Gly Trp 
    770                 775                 780                 

Tyr Tyr Leu Lys Trp Tyr Gln Leu Tyr Gly Lys Phe Ala Glu Tyr Ala 
785                 790                 795                 800 

Asn Thr Leu Ala Ala Met Ala Lys Glu Arg Gly Leu Gln Pro Met Ala 
                805                 810                 815     

Phe Asn Asp Gly Phe Tyr Tyr Glu Asp Lys Asp Asp Val Gln Phe Asp 
            820                 825                 830         

Lys Asp Val Leu Ile Ser Tyr Trp Ser Lys Gly Trp Trp Gly Tyr Asn 
        835                 840                 845             

Leu Ala Ser Pro Gln Tyr Leu Ala Ser Lys Gly Tyr Lys Phe Leu Asn 
    850                 855                 860                 

Thr Asn Gly Asp Trp Tyr Tyr Ile Leu Gly Gln Lys Pro Glu Asp Gly 
865                 870                 875                 880 

Gly Gly Phe Leu Lys Lys Ala Ile Glu Asn Thr Gly Lys Thr Pro Phe 
                885                 890                 895     

Asn Gln Leu Ala Ser Thr Lys Tyr Pro Glu Val Asp Leu Pro Thr Val 
            900                 905                 910         

Gly Ser Met Leu Ser Ile Trp Ala Asp Arg Pro Ser Ala Glu Tyr Lys 
        915                 920                 925             

Glu Glu Glu Ile Phe Glu Leu Met Thr Ala Phe Ala Asp His Asn Lys 
    930                 935                 940                 

Asp Tyr Phe Arg Ala Asn Tyr Asn Ala Leu Arg Glu Glu Leu Ala Lys 
945                 950                 955                 960 

Ile Pro Thr Asn Leu Glu Gly Tyr Ser Lys Glu Ser Leu Glu Ala Leu 
                965                 970                 975     

Asp Ala Ala Lys Thr Ala Leu Asn Tyr Asn Leu Asn Arg Asn Lys Gln 
            980                 985                 990         

Ala Glu Leu Asp Thr Leu Val Ala Asn Leu Lys Ala Ala Leu Gln Gly 
        995                 1000                1005            

Leu Lys Pro Ala Val Thr His Ser Gly Ser Leu Asp Glu Asn Glu Val 
    1010                1015                1020                

Ala Ala Asn Val Glu Thr Arg Pro Glu Leu Ile Thr Arg Thr Glu Glu 
1025                1030                1035                1040

Ile Pro Phe Glu Val Ile Lys Lys Glu Asn Pro Asn Leu Pro Ala Gly 
                1045                1050                1055    

Gln Glu Asn Ile Ile Thr Ala Gly Val Lys Gly Glu Arg Thr His Tyr 
            1060                1065                1070        

Ile Ser Val Leu Thr Glu Asn Gly Lys Thr Thr Glu Thr Val Leu Asp 
        1075                1080                1085            

Ser Gln Val Thr Lys Glu Val Ile Asn Gln Val Val Glu Val Gly Ala 
    1090                1095                1100                

Pro Val Thr His Lys Gly Asp Glu Ser Gly Leu Ala Pro Thr Thr Glu 
1105                1110                1115                1120

Val Lys Pro Arg Leu Asp Ile Gln Glu Glu Glu Ile Pro Phe Thr Thr 
                1125                1130                1135    

Val Thr Cys Glu Asn Pro Leu Leu Leu Lys Gly Lys Thr Gln Val Ile 
            1140                1145                1150        

Thr Lys Gly Val Asn Gly His Arg Ser Asn Phe Tyr Ser Val Ser Thr 
        1155                1160                1165            

Ser Ala Asp Gly Lys Glu Val Lys Thr Leu Val Asn Ser Val Val Ala 
    1170                1175                1180                

Gln Glu Ala Val Thr Gln Ile Val Glu Val Gly Thr Met Val Thr His 
1185                1190                1195                1200

Val Gly Asp Glu Asn Gly Gln Ala Ala Ile Ala Glu Glu Lys Pro Lys 
                1205                1210                1215    

Leu Glu Ile Pro Ser Gln Pro Ala Pro Ser Thr Ala Pro Ala Glu Glu 
            1220                1225                1230        

Ser Lys Val Leu Pro Gln Asp Pro Ala Pro Val Val Thr Glu Lys Lys 
        1235                1240                1245            

Gly Ser Gly Ser Gly Gly Gly Gly Ile Ala Glu Glu Asp Lys Ala Lys 
    1250                1255                1260                

Leu Ala Ile Pro Gly Ser Arg Ile Gln Ala Thr Gly Tyr Leu Glu Gly 
1265                1270                1275                1280

Gln Pro Ile His Ala Thr Leu Val Val Glu Glu Gly Asn Pro Ala Ala 
                1285                1290                1295    

Pro Ala Val Pro Thr Val Thr Val Gly Gly Glu Ala Val Thr Gly Leu 
            1300                1305                1310        

Thr Ser Gln Lys Pro Met Gln Tyr Arg Thr Leu Ala Tyr Gly Ala Lys 
        1315                1320                1325            

Leu Pro Glu Val Thr Ala Ser Ala Lys Asn Ala Ala Val Thr Val Leu 
    1330                1335                1340                

Gln Ala Ser Ala Ala Asn Gly Met Arg Ala Ser Ile Phe Ile Gln Pro 
1345                1350                1355                1360

Lys Asp Gly Gly Pro Leu Gln Thr Tyr Ala Ile Gln Phe Leu Glu Glu 
                1365                1370                1375    

Ala Pro Lys Ile Ala His Leu Ser Leu Gln Val Glu Lys Ala Asp Ser 
            1380                1385                1390        

Leu Lys Glu Asp Gln Thr Val Lys Leu Ser Val Arg Ala His Tyr Gln 
        1395                1400                1405            

Asp Gly Thr Gln Ala Val Leu Pro Ala Asp Lys Val Thr Phe Ser Thr 
    1410                1415                1420                

Ser Gly Glu Gly Glu Val Ala Ile Arg Lys Gly Met Leu Glu Leu His 
1425                1430                1435                1440

Lys Pro Gly Ala Val Thr Leu Asn Ala Glu Tyr Glu Gly Ala Lys Asp 
                1445                1450                1455    

Gln Val Glu Leu Thr Ile Gln Ala Asn Thr Glu Lys Lys Ile Ala Gln 
            1460                1465                1470        

Ser Ile Arg Pro Val Asn Val Val Thr Asp Leu His Gln Glu Pro Ser 
        1475                1480                1485            

Leu Pro Ala Thr Val Thr Val Glu Tyr Asp Lys Gly Phe Pro Lys Thr 
    1490                1495                1500                

His Lys Val Thr Trp Gln Ala Ile Pro Lys Glu Lys Leu Asp Ser Tyr 
1505                1510                1515                1520

Gln Thr Phe Glu Val Leu Gly Lys Val Glu Gly Ile Asp Leu Glu Ala 
                1525                1530                1535    

Arg Ala Lys Val Ser Val Glu Gly Ile Val Ser Val Glu Glu Val Ser 
            1540                1545                1550        

Val Thr Thr Pro Ile Ala Glu Ala Pro Gln Leu Pro Glu Ser Val Arg 
        1555                1560                1565            

Thr Tyr Asp Ser Asn Gly His Val Ser Ser Ala Lys Val Ala Trp Asp 
    1570                1575                1580                

Ala Ile Arg Pro Glu Gln Tyr Ala Lys Glu Gly Val Phe Thr Val Asn 
1585                1590                1595                1600

Gly Arg Leu Glu Gly Thr Gln Leu Thr Thr Lys Leu His Val Arg Val 
                1605                1610                1615    

Ser Ala Gln Thr Glu Gln Gly Ala Asn Ile Ser Asp Gln Trp Thr Gly 
            1620                1625                1630        

Ser Glu Leu Pro Leu Ala Phe Ala Ser Asp Ser Asn Pro Ser Asp Pro 
        1635                1640                1645            

Val Ser Asn Val Asn Asp Lys Leu Ile Ser Tyr Asn Asn Gln Pro Ala 
    1650                1655                1660                

Asn Arg Trp Thr Asn Trp Asn Arg Thr Asn Pro Glu Ala Ser Val Gly 
1665                1670                1675                1680

Val Leu Phe Gly Asp Ser Gly Ile Leu Ser Lys Arg Ser Val Asp Asn 
                1685                1690                1695    

Leu Ser Val Gly Phe His Glu Asp His Gly Val Gly Val Pro Lys Ser 
            1700                1705                1710        

Tyr Val Ile Glu Tyr Tyr Val Gly Lys Thr Val Pro Thr Ala Pro Lys 
        1715                1720                1725            

Asn Pro Ser Phe Val Gly Asn Glu Asp His Val Phe Asn Asp Ser Ala 
    1730                1735                1740                

Asn Trp Lys Pro Val Thr Asn Leu Lys Ala Pro Ala Gln Leu Lys Ala 
1745                1750                1755                1760

Gly Glu Met Asn His Phe Ser Phe Asp Lys Val Glu Thr Tyr Ala Val 
                1765                1770                1775    

Arg Ile Arg Met Val Lys Ala Asp Asn Lys Arg Gly Thr Ser Ile Thr 
            1780                1785                1790        

Glu Val Gln Ile Phe Ala Lys Gln Val Ala Ala Ala Lys Gln Gly Gln 
        1795                1800                1805            

Thr Arg Ile Gln Val Asp Gly Lys Asp Leu Ala Asn Phe Asn Pro Asp 
    1810                1815                1820                

Leu Thr Asp Tyr Tyr Leu Glu Ser Val Asp Gly Lys Val Pro Ala Val 
1825                1830                1835                1840

Thr Ala Ser Val Ser Asn Asn Gly Leu Ala Thr Val Val Pro Ser Val 
                1845                1850                1855    

Arg Glu Gly Glu Pro Val Arg Val Ile Ala Lys Ala Glu Asn Gly Asp 
            1860                1865                1870        

Ile Leu Gly Glu Tyr Arg Leu His Phe Thr Lys Asp Lys Ser Leu Leu 
        1875                1880                1885            

Ser His Lys Pro Val Ala Ala Val Lys Gln Ala Arg Leu Leu Gln Val 
    1890                1895                1900                

Gly Gln Ala Leu Glu Leu Pro Thr Lys Val Pro Val Tyr Phe Thr Gly 
1905                1910                1915                1920

Lys Asp Gly Tyr Glu Thr Lys Asp Leu Thr Val Glu Trp Glu Glu Val 
                1925                1930                1935    

Pro Ala Glu Asn Leu Thr Lys Ala Gly Gln Phe Thr Val Arg Gly Arg 
            1940                1945                1950        

Val Leu Gly Ser Asn Leu Val Ala Glu Ile Thr Val Arg Val Thr Asp 
        1955                1960                1965            

Lys Leu Gly Glu Thr Leu Ser Asp Asn Pro Asn Tyr Asp Glu Asn Ser 
    1970                1975                1980                

Asn Gln Ala Phe Ala Ser Ala Thr Asn Asp Ile Asp Lys Asn Ser His 
1985                1990                1995                2000

Asp Arg Val Asp Tyr Leu Asn Asp Gly Asp His Ser Glu Asn Arg Arg 
                2005                2010                2015    

Trp Thr Asn Trp Ser Pro Thr Pro Ser Ser Asn Pro Glu Val Ser Ala 
            2020                2025                2030        

Gly Val Ile Phe Arg Glu Asn Gly Lys Ile Val Glu Arg Thr Val Thr 
        2035                2040                2045            

Gln Gly Lys Val Gln Phe Phe Ala Asp Ser Gly Thr Asp Ala Pro Ser 
    2050                2055                2060                

Lys Leu Val Leu Glu Arg Tyr Val Gly Pro Glu Phe Glu Val Pro Thr 
2065                2070                2075                2080

Tyr Tyr Ser Asn Tyr Gln Ala Tyr Asp Ala Asp His Pro Phe Asn Asn 
                2085                2090                2095    

Pro Glu Asn Trp Glu Ala Val Pro Tyr Arg Ala Asp Lys Asp Ile Ala 
            2100                2105                2110        

Ala Gly Asp Glu Ile Asn Val Thr Phe Lys Ala Ile Lys Ala Lys Ala 
        2115                2120                2125            

Met Arg Trp Arg Met Glu Arg Lys Ala Asp Lys Ser Gly Val Ala Met 
    2130                2135                2140                

Ile Glu Met Thr Phe Leu Ala Pro Ser Glu Leu Pro Gln Glu Ser Thr 
2145                2150                2155                2160

Gln Ser Lys Ile Leu Val Asp Gly Lys Glu Leu Ala Asp Phe Ala Glu 
                2165                2170                2175    

Asn Arg Gln Asp Tyr Gln Ile Thr Tyr Lys Gly Gln Arg Pro Lys Val 
            2180                2185                2190        

Ser Val Glu Glu Asn Asn Gln Val Ala Ser Thr Val Val Asp Ser Gly 
        2195                2200                2205            

Glu Asp Ser Phe Pro Val Leu Val Arg Leu Val Ser Glu Ser Gly Lys 
    2210                2215                2220                

Gln Val Lys Glu Tyr Arg Ile His Leu Thr Lys Glu Lys Pro Val Ser 
2225                2230                2235                2240

Glu Lys Thr Val Ala Ala Val Gln Glu Asp Leu Pro Lys Ile Glu Phe 
                2245                2250                2255    

Val Glu Lys Asp Leu Ala Tyr Lys Thr Val Glu Lys Lys Asp Ser Thr 
            2260                2265                2270        

Leu Tyr Leu Gly Glu Thr Arg Val Glu Gln Glu Gly Lys Val Gly Lys 
        2275                2280                2285            

Glu Arg Ile Phe Thr Ala Ile Asn Pro Asp Gly Ser Lys Glu Glu Lys 
    2290                2295                2300                

Leu Arg Glu Val Val Glu Val Pro Thr Asp Arg Ile Val Leu Val Gly 
2305                2310                2315                2320

Thr Lys Pro Val Ala Gln Glu Ala Lys Lys Pro Gln Val Ser Glu Lys 
                2325                2330                2335    

Ala Asp Thr Lys Pro Ile Asp Ser Ser Glu Ala Ser Gln Thr Asn Lys 
            2340                2345                2350        

Ala Gln Ala Ala Ala Leu Glu His His His His His His 
        2355                2360                2365

<210>   205
<211>   555
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Hybrid polypeptide

<400>   205
Met Val Ser Ala Gln Glu Ser Ser Thr Tyr Thr Val Lys Glu Gly Asp 
1               5                   10                  15      

Thr Leu Ser Glu Ile Ala Glu Thr His Asn Thr Thr Val Glu Lys Leu 
            20                  25                  30          

Ala Glu Asn Asn His Ile Asp Asn Ile His Leu Ile Tyr Val Asp Gln 
        35                  40                  45              

Glu Leu Val Ile Asp Gly Pro Val Ala Pro Val Ala Thr Pro Ala Pro 
    50                  55                  60                  

Ala Thr Tyr Ala Ala Pro Ala Ala Gln Asp Glu Thr Val Ser Ala Pro 
65                  70                  75                  80  

Val Ala Glu Thr Pro Val Val Ser Glu Thr Val Val Ser Thr Val Ser 
                85                  90                  95      

Gly Ser Glu Ala Glu Ala Lys Glu Trp Ile Ala Gln Lys Glu Ser Gly 
            100                 105                 110         

Gly Ser Tyr Thr Ala Thr Asn Gly Arg Tyr Ile Gly Arg Tyr Gln Leu 
        115                 120                 125             

Thr Asp Ser Tyr Leu Asn Gly Asp Tyr Ser Ala Glu Asn Gln Glu Arg 
    130                 135                 140                 

Val Ala Asp Ala Tyr Val Ala Gly Arg Tyr Gly Ser Trp Thr Ala Ala 
145                 150                 155                 160 

Lys Asn Phe Trp Leu Asn Asn Gly Trp Tyr Gly Ser Gly Ser Gly Gly 
                165                 170                 175     

Gly Gly Ala Glu Thr Thr Asp Asp Lys Ile Ala Ala Gln Asp Asn Lys 
            180                 185                 190         

Ile Ser Asn Leu Thr Ala Gln Gln Gln Glu Ala Gln Lys Gln Val Asp 
        195                 200                 205             

Gln Ile Gln Glu Gln Val Ser Ala Ile Gln Ala Glu Gln Ser Asn Leu 
    210                 215                 220                 

Gln Ala Glu Asn Asp Arg Leu Gln Ala Glu Ser Lys Lys Leu Glu Gly 
225                 230                 235                 240 

Glu Ile Thr Glu Leu Ser Lys Asn Ile Val Ser Arg Asn Gln Ser Leu 
                245                 250                 255     

Glu Lys Gln Ala Arg Ser Ala Gln Thr Asn Gly Ala Val Thr Ser Tyr 
            260                 265                 270         

Ile Asn Thr Ile Val Asn Ser Lys Ser Ile Thr Glu Ala Ile Ser Arg 
        275                 280                 285             

Val Ala Ala Met Ser Glu Ile Val Ser Ala Asn Asn Lys Met Leu Glu 
    290                 295                 300                 

Gln Gln Lys Ala Asp Lys Lys Ala Ile Ser Glu Lys Gln Val Ala Asn 
305                 310                 315                 320 

Asn Asp Ala Ile Asn Thr Val Ile Ala Asn Gln Gln Lys Leu Ala Asp 
                325                 330                 335     

Asp Ala Gln Ala Leu Thr Thr Lys Gln Ala Glu Leu Lys Ala Ala Glu 
            340                 345                 350         

Leu Ser Leu Ala Ala Glu Lys Ala Thr Ala Glu Gly Glu Lys Ala Ser 
        355                 360                 365             

Leu Leu Glu Gln Lys Ala Ala Ala Glu Ala Glu Ala Arg Ala Ala Ala 
    370                 375                 380                 

Val Ala Glu Ala Ala Tyr Lys Glu Lys Arg Ala Ser Gln Gln Gln Ser 
385                 390                 395                 400 

Val Leu Ala Ser Ala Asn Thr Asn Leu Thr Ala Gln Val Gln Ala Val 
                405                 410                 415     

Ser Glu Ser Ala Ala Ala Pro Val Arg Ala Lys Val Arg Pro Thr Tyr 
            420                 425                 430         

Ser Thr Asn Ala Ser Ser Tyr Pro Ile Gly Glu Cys Thr Trp Gly Val 
        435                 440                 445             

Lys Thr Leu Ala Pro Trp Ala Gly Asp Tyr Trp Gly Asn Gly Ala Gln 
    450                 455                 460                 

Trp Ala Thr Ser Ala Ala Ala Ala Gly Phe Arg Thr Gly Ser Thr Pro 
465                 470                 475                 480 

Gln Val Gly Ala Ile Ala Cys Trp Asn Asp Gly Gly Tyr Gly His Val 
                485                 490                 495     

Ala Val Val Thr Ala Val Glu Ser Thr Thr Arg Ile Gln Val Ser Glu 
            500                 505                 510         

Ser Asn Tyr Ala Gly Asn Arg Thr Ile Gly Asn His Arg Gly Trp Phe 
        515                 520                 525             

Asn Pro Thr Thr Thr Ser Glu Gly Phe Val Thr Tyr Ile Tyr Ala Asp 
    530                 535                 540                 

Ala Ala Ala Leu Glu His His His His His His 
545                 550                 555 

<210>   206
<211>   1433
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Hybrid polypeptide

<400>   206
Met Val Ser Ala Gln Glu Ser Ser Thr Tyr Thr Val Lys Glu Gly Asp 
1               5                   10                  15      

Thr Leu Ser Glu Ile Ala Glu Thr His Asn Thr Thr Val Glu Lys Leu 
            20                  25                  30          

Ala Glu Asn Asn His Ile Asp Asn Ile His Leu Ile Tyr Val Asp Gln 
        35                  40                  45              

Glu Leu Val Ile Asp Gly Pro Val Ala Pro Val Ala Thr Pro Ala Pro 
    50                  55                  60                  

Ala Thr Tyr Ala Ala Pro Ala Ala Gln Asp Glu Thr Val Ser Ala Pro 
65                  70                  75                  80  

Val Ala Glu Thr Pro Val Val Ser Glu Thr Val Val Ser Thr Val Ser 
                85                  90                  95      

Gly Ser Glu Ala Glu Ala Lys Glu Trp Ile Ala Gln Lys Glu Ser Gly 
            100                 105                 110         

Gly Ser Tyr Thr Ala Thr Asn Gly Arg Tyr Ile Gly Arg Tyr Gln Leu 
        115                 120                 125             

Thr Asp Ser Tyr Leu Asn Gly Asp Tyr Ser Ala Glu Asn Gln Glu Arg 
    130                 135                 140                 

Val Ala Asp Ala Tyr Val Ala Gly Arg Tyr Gly Ser Trp Thr Ala Ala 
145                 150                 155                 160 

Lys Asn Phe Trp Leu Asn Asn Gly Trp Tyr Gly Ser Gly Ser Gly Gly 
                165                 170                 175     

Gly Gly Ala Asp Gly Val Thr Pro Thr Thr Thr Glu Asn Gln Pro Thr 
            180                 185                 190         

Ile His Thr Val Ser Asp Ser Pro Gln Ser Ser Glu Asn Arg Thr Glu 
        195                 200                 205             

Glu Thr Pro Lys Ala Val Leu Gln Pro Glu Ala Pro Lys Thr Val Glu 
    210                 215                 220                 

Thr Glu Thr Pro Ala Thr Asp Lys Val Ala Ser Leu Pro Lys Thr Glu 
225                 230                 235                 240 

Glu Lys Pro Gln Glu Glu Val Ser Ser Thr Pro Ser Asp Lys Ala Glu 
                245                 250                 255     

Val Val Thr Pro Thr Ser Ala Glu Lys Glu Thr Ala Asn Lys Lys Ala 
            260                 265                 270         

Glu Glu Ala Ser Pro Lys Lys Glu Glu Ala Lys Glu Val Asp Ser Lys 
        275                 280                 285             

Glu Ser Asn Thr Asp Lys Thr Asp Lys Asp Lys Pro Ala Lys Lys Asp 
    290                 295                 300                 

Glu Ala Lys Ala Glu Ala Asp Lys Pro Ala Thr Glu Ala Gly Lys Glu 
305                 310                 315                 320 

Arg Ala Ala Thr Val Asn Glu Lys Leu Ala Lys Lys Lys Ile Val Ser 
                325                 330                 335     

Ile Asp Ala Gly Arg Lys Tyr Phe Ser Pro Glu Gln Leu Lys Glu Ile 
            340                 345                 350         

Ile Asp Lys Ala Lys His Tyr Gly Tyr Thr Asp Leu His Leu Leu Val 
        355                 360                 365             

Gly Asn Asp Gly Leu Arg Phe Met Leu Asp Asp Met Ser Ile Thr Ala 
    370                 375                 380                 

Asn Gly Lys Thr Tyr Ala Ser Asp Asp Val Lys Arg Ala Ile Glu Lys 
385                 390                 395                 400 

Gly Thr Asn Asp Tyr Tyr Asn Asp Pro Asn Gly Asn His Leu Thr Glu 
                405                 410                 415     

Ser Gln Met Thr Asp Leu Ile Asn Tyr Ala Lys Asp Lys Gly Ile Gly 
            420                 425                 430         

Leu Ile Pro Thr Val Asn Ser Pro Gly His Met Asp Ala Ile Leu Asn 
        435                 440                 445             

Ala Met Lys Glu Leu Gly Ile Gln Asn Pro Asn Phe Ser Tyr Phe Gly 
    450                 455                 460                 

Lys Lys Ser Ala Arg Thr Val Asp Leu Asp Asn Glu Gln Ala Val Ala 
465                 470                 475                 480 

Phe Thr Lys Ala Leu Ile Asp Lys Tyr Ala Ala Tyr Phe Ala Lys Lys 
                485                 490                 495     

Thr Glu Ile Phe Asn Ile Gly Leu Asp Glu Tyr Ala Asn Asp Ala Thr 
            500                 505                 510         

Asp Ala Lys Gly Trp Ser Val Leu Gln Ala Asp Lys Tyr Tyr Pro Asn 
        515                 520                 525             

Glu Gly Tyr Pro Val Lys Gly Tyr Glu Lys Phe Ile Ala Tyr Ala Asn 
    530                 535                 540                 

Asp Leu Ala Arg Ile Val Lys Ser His Gly Leu Lys Pro Met Ala Phe 
545                 550                 555                 560 

Asn Asp Gly Ile Tyr Tyr Asn Ser Asp Thr Ser Phe Gly Ser Phe Asp 
                565                 570                 575     

Lys Asp Ile Ile Val Ser Met Trp Thr Gly Gly Trp Gly Gly Tyr Asp 
            580                 585                 590         

Val Ala Ser Ser Lys Leu Leu Ala Glu Lys Gly His Gln Ile Leu Asn 
        595                 600                 605             

Thr Asn Asp Ala Trp Tyr Tyr Val Leu Gly Arg Asn Ala Asp Gly Gln 
    610                 615                 620                 

Gly Trp Tyr Asn Leu Asp Gln Gly Leu Asn Gly Ile Lys Asn Thr Pro 
625                 630                 635                 640 

Ile Thr Ser Val Pro Lys Thr Glu Gly Ala Asp Ile Pro Ile Ile Gly 
                645                 650                 655     

Gly Met Val Ala Ala Trp Ala Asp Thr Pro Ser Ala Arg Tyr Ser Pro 
            660                 665                 670         

Ser Arg Leu Phe Lys Leu Met Arg His Phe Ala Asn Ala Asn Ala Glu 
        675                 680                 685             

Tyr Phe Ala Ala Asp Tyr Glu Ser Ala Glu Gln Ala Leu Asn Glu Val 
    690                 695                 700                 

Pro Lys Asp Leu Asn Arg Tyr Thr Ala Glu Ser Val Thr Ala Val Lys 
705                 710                 715                 720 

Glu Ala Glu Lys Ala Ile Arg Ser Leu Asp Ser Asn Leu Ser Arg Ala 
                725                 730                 735     

Gln Gln Asp Thr Ile Asp Gln Ala Ile Ala Lys Leu Gln Glu Thr Val 
            740                 745                 750         

Asn Asn Leu Thr Leu Thr Pro Glu Ala Gln Lys Glu Glu Glu Ala Lys 
        755                 760                 765             

Arg Glu Val Glu Lys Leu Ala Lys Asn Lys Val Ile Ser Ile Asp Ala 
    770                 775                 780                 

Gly Arg Lys Tyr Phe Thr Leu Asn Gln Leu Lys Arg Ile Val Asp Lys 
785                 790                 795                 800 

Ala Ser Glu Leu Gly Tyr Ser Asp Val His Leu Leu Leu Gly Asn Asp 
                805                 810                 815     

Gly Leu Arg Phe Leu Leu Asp Asp Met Thr Ile Thr Ala Asn Gly Lys 
            820                 825                 830         

Thr Tyr Ala Ser Asp Asp Val Lys Lys Ala Ile Ile Glu Gly Thr Lys 
        835                 840                 845             

Ala Tyr Tyr Asp Asp Pro Asn Gly Thr Ala Leu Thr Gln Ala Glu Val 
    850                 855                 860                 

Thr Glu Leu Ile Glu Tyr Ala Lys Ser Lys Asp Ile Gly Leu Ile Pro 
865                 870                 875                 880 

Ala Ile Asn Ser Pro Gly His Met Asp Ala Met Leu Val Ala Met Glu 
                885                 890                 895     

Lys Leu Gly Ile Lys Asn Pro Gln Ala His Phe Asp Lys Val Ser Lys 
            900                 905                 910         

Thr Thr Met Asp Leu Lys Asn Glu Glu Ala Met Asn Phe Val Lys Ala 
        915                 920                 925             

Leu Ile Gly Lys Tyr Met Asp Phe Phe Ala Gly Lys Thr Lys Ile Phe 
    930                 935                 940                 

Asn Phe Gly Thr Asp Glu Tyr Ala Asn Asp Ala Thr Ser Ala Gln Gly 
945                 950                 955                 960 

Trp Tyr Tyr Leu Lys Trp Tyr Gln Leu Tyr Gly Lys Phe Ala Glu Tyr 
                965                 970                 975     

Ala Asn Thr Leu Ala Ala Met Ala Lys Glu Arg Gly Leu Gln Pro Met 
            980                 985                 990         

Ala Phe Asn Asp Gly Phe Tyr Tyr Glu Asp Lys Asp Asp Val Gln Phe 
        995                 1000                1005            

Asp Lys Asp Val Leu Ile Ser Tyr Trp Ser Lys Gly Trp Trp Gly Tyr 
    1010                1015                1020                

Asn Leu Ala Ser Pro Gln Tyr Leu Ala Ser Lys Gly Tyr Lys Phe Leu 
1025                1030                1035                1040

Asn Thr Asn Gly Asp Trp Tyr Tyr Ile Leu Gly Gln Lys Pro Glu Asp 
                1045                1050                1055    

Gly Gly Gly Phe Leu Lys Lys Ala Ile Glu Asn Thr Gly Lys Thr Pro 
            1060                1065                1070        

Phe Asn Gln Leu Ala Ser Thr Lys Tyr Pro Glu Val Asp Leu Pro Thr 
        1075                1080                1085            

Val Gly Ser Met Leu Ser Ile Trp Ala Asp Arg Pro Ser Ala Glu Tyr 
    1090                1095                1100                

Lys Glu Glu Glu Ile Phe Glu Leu Met Thr Ala Phe Ala Asp His Asn 
1105                1110                1115                1120

Lys Asp Tyr Phe Arg Ala Asn Tyr Asn Ala Leu Arg Glu Glu Leu Ala 
                1125                1130                1135    

Lys Ile Pro Thr Asn Leu Glu Gly Tyr Ser Lys Glu Ser Leu Glu Ala 
            1140                1145                1150        

Leu Asp Ala Ala Lys Thr Ala Leu Asn Tyr Asn Leu Asn Arg Asn Lys 
        1155                1160                1165            

Gln Ala Glu Leu Asp Thr Leu Val Ala Asn Leu Lys Ala Ala Leu Gln 
    1170                1175                1180                

Gly Leu Lys Pro Ala Val Thr His Ser Gly Ser Leu Asp Glu Asn Glu 
1185                1190                1195                1200

Val Ala Ala Asn Val Glu Thr Arg Pro Glu Leu Ile Thr Arg Thr Glu 
                1205                1210                1215    

Glu Ile Pro Phe Glu Val Ile Lys Lys Glu Asn Pro Asn Leu Pro Ala 
            1220                1225                1230        

Gly Gln Glu Asn Ile Ile Thr Ala Gly Val Lys Gly Glu Arg Thr His 
        1235                1240                1245            

Tyr Ile Ser Val Leu Thr Glu Asn Gly Lys Thr Thr Glu Thr Val Leu 
    1250                1255                1260                

Asp Ser Gln Val Thr Lys Glu Val Ile Asn Gln Val Val Glu Val Gly 
1265                1270                1275                1280

Ala Pro Val Thr His Lys Gly Asp Glu Ser Gly Leu Ala Pro Thr Thr 
                1285                1290                1295    

Glu Val Lys Pro Arg Leu Asp Ile Gln Glu Glu Glu Ile Pro Phe Thr 
            1300                1305                1310        

Thr Val Thr Cys Glu Asn Pro Leu Leu Leu Lys Gly Lys Thr Gln Val 
        1315                1320                1325            

Ile Thr Lys Gly Val Asn Gly His Arg Ser Asn Phe Tyr Ser Val Ser 
    1330                1335                1340                

Thr Ser Ala Asp Gly Lys Glu Val Lys Thr Leu Val Asn Ser Val Val 
1345                1350                1355                1360

Ala Gln Glu Ala Val Thr Gln Ile Val Glu Val Gly Thr Met Val Thr 
                1365                1370                1375    

His Val Gly Asp Glu Asn Gly Gln Ala Ala Ile Ala Glu Glu Lys Pro 
            1380                1385                1390        

Lys Leu Glu Ile Pro Ser Gln Pro Ala Pro Ser Thr Ala Pro Ala Glu 
        1395                1400                1405            

Glu Ser Lys Val Leu Pro Gln Asp Pro Ala Pro Val Val Thr Glu Lys 
    1410                1415                1420                

Lys Leu Glu His His His His His His 
1425                1430            

<210>   207
<211>   1010
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Hybrid polypeptide

<400>   207
Met Val Ser Ala Gln Glu Ser Ser Thr Tyr Thr Val Lys Glu Gly Asp 
1               5                   10                  15      

Thr Leu Ser Glu Ile Ala Glu Thr His Asn Thr Thr Val Glu Lys Leu 
            20                  25                  30          

Ala Glu Asn Asn His Ile Asp Asn Ile His Leu Ile Tyr Val Asp Gln 
        35                  40                  45              

Glu Leu Val Ile Asp Gly Pro Val Ala Pro Val Ala Thr Pro Ala Pro 
    50                  55                  60                  

Ala Thr Tyr Ala Ala Pro Ala Ala Gln Asp Glu Thr Val Ser Ala Pro 
65                  70                  75                  80  

Val Ala Glu Thr Pro Val Val Ser Glu Thr Val Val Ser Thr Val Ser 
                85                  90                  95      

Gly Ser Glu Ala Glu Ala Lys Glu Trp Ile Ala Gln Lys Glu Ser Gly 
            100                 105                 110         

Gly Ser Tyr Thr Ala Thr Asn Gly Arg Tyr Ile Gly Arg Tyr Gln Leu 
        115                 120                 125             

Thr Asp Ser Tyr Leu Asn Gly Asp Tyr Ser Ala Glu Asn Gln Glu Arg 
    130                 135                 140                 

Val Ala Asp Ala Tyr Val Ala Gly Arg Tyr Gly Ser Trp Thr Ala Ala 
145                 150                 155                 160 

Lys Asn Phe Trp Leu Asn Asn Gly Trp Tyr Gly Ser Gly Ser Gly Gly 
                165                 170                 175     

Gly Gly Glu Thr Pro Glu Thr Ser Pro Ala Ile Gly Lys Val Val Ile 
            180                 185                 190         

Lys Glu Thr Gly Glu Gly Gly Ala Leu Leu Gly Asp Ala Val Phe Glu 
        195                 200                 205             

Leu Lys Asn Asn Thr Asp Gly Thr Thr Val Ser Gln Arg Thr Glu Ala 
    210                 215                 220                 

Gln Thr Gly Glu Ala Ile Phe Ser Asn Ile Lys Pro Gly Thr Tyr Thr 
225                 230                 235                 240 

Leu Thr Glu Ala Gln Pro Pro Val Gly Tyr Lys Pro Ser Thr Lys Gln 
                245                 250                 255     

Trp Thr Val Glu Val Glu Lys Asn Gly Arg Thr Thr Val Gln Gly Glu 
            260                 265                 270         

Gln Val Glu Asn Arg Glu Glu Ala Leu Ser Asp Gln Tyr Pro Gln Thr 
        275                 280                 285             

Gly Thr Tyr Pro Asp Val Gln Thr Pro Tyr Gln Ile Ile Lys Val Asp 
    290                 295                 300                 

Gly Ser Glu Lys Asn Gly Gln His Lys Ala Leu Asn Pro Asn Pro Tyr 
305                 310                 315                 320 

Glu Arg Val Ile Pro Glu Gly Thr Leu Ser Lys Arg Ile Tyr Gln Val 
                325                 330                 335     

Asn Asn Leu Asp Asp Asn Gln Tyr Gly Ile Glu Leu Thr Val Ser Gly 
            340                 345                 350         

Lys Thr Val Tyr Glu Gln Lys Asp Lys Ser Val Pro Leu Asp Val Val 
        355                 360                 365             

Ile Leu Leu Asp Asn Ser Asn Ser Met Ser Asn Ile Arg Asn Lys Asn 
    370                 375                 380                 

Ala Arg Arg Ala Glu Arg Ala Gly Glu Ala Thr Arg Ser Leu Ile Asp 
385                 390                 395                 400 

Lys Ile Thr Ser Asp Ser Glu Asn Arg Val Ala Leu Val Thr Tyr Ala 
                405                 410                 415     

Ser Thr Ile Phe Asp Gly Thr Glu Phe Thr Val Glu Lys Gly Val Ala 
            420                 425                 430         

Asp Lys Asn Gly Lys Arg Leu Asn Asp Ser Leu Phe Trp Asn Tyr Asp 
        435                 440                 445             

Gln Thr Ser Phe Thr Thr Asn Thr Lys Asp Tyr Ser Tyr Leu Lys Leu 
    450                 455                 460                 

Thr Asn Asp Lys Asn Asp Ile Val Glu Leu Lys Asn Lys Val Pro Thr 
465                 470                 475                 480 

Glu Ala Glu Asp His Asp Gly Asn Arg Leu Met Tyr Gln Phe Gly Ala 
                485                 490                 495     

Thr Phe Thr Gln Lys Ala Leu Met Lys Ala Asp Glu Ile Leu Thr Gln 
            500                 505                 510         

Gln Ala Arg Gln Asn Ser Gln Lys Val Ile Phe His Ile Thr Asp Gly 
        515                 520                 525             

Val Pro Thr Met Ser Tyr Pro Ile Asn Phe Asn His Ala Thr Phe Ala 
    530                 535                 540                 

Pro Ser Tyr Gln Asn Gln Leu Asn Ala Phe Phe Ser Lys Ser Pro Asn 
545                 550                 555                 560 

Lys Asp Gly Ile Leu Leu Ser Asp Phe Ile Thr Gln Ala Thr Ser Gly 
                565                 570                 575     

Glu His Thr Ile Val Arg Gly Asp Gly Gln Ser Tyr Gln Met Phe Thr 
            580                 585                 590         

Asp Lys Thr Val Tyr Glu Lys Gly Ala Pro Ala Ala Phe Pro Val Lys 
        595                 600                 605             

Pro Glu Lys Tyr Ser Glu Met Lys Ala Ala Gly Tyr Ala Val Ile Gly 
    610                 615                 620                 

Asp Pro Ile Asn Gly Gly Tyr Ile Trp Leu Asn Trp Arg Glu Ser Ile 
625                 630                 635                 640 

Leu Ala Tyr Pro Phe Asn Ser Asn Thr Ala Lys Ile Thr Asn His Gly 
                645                 650                 655     

Asp Pro Thr Arg Trp Tyr Tyr Asn Gly Asn Ile Ala Pro Asp Gly Tyr 
            660                 665                 670         

Asp Val Phe Thr Val Gly Ile Gly Ile Asn Gly Asp Pro Gly Thr Asp 
        675                 680                 685             

Glu Ala Thr Ala Thr Ser Phe Met Gln Ser Ile Ser Ser Lys Pro Glu 
    690                 695                 700                 

Asn Tyr Thr Asn Val Thr Asp Thr Thr Lys Ile Leu Glu Gln Leu Asn 
705                 710                 715                 720 

Arg Tyr Phe His Thr Ile Val Thr Glu Lys Lys Ser Ile Glu Asn Gly 
                725                 730                 735     

Thr Ile Thr Asp Pro Met Gly Glu Leu Ile Asp Leu Gln Leu Gly Thr 
            740                 745                 750         

Asp Gly Arg Phe Asp Pro Ala Asp Tyr Thr Leu Thr Ala Asn Asp Gly 
        755                 760                 765             

Ser Arg Leu Glu Asn Gly Gln Ala Val Gly Gly Pro Gln Asn Asp Gly 
    770                 775                 780                 

Gly Leu Leu Lys Asn Ala Lys Val Leu Tyr Asp Thr Thr Glu Lys Arg 
785                 790                 795                 800 

Ile Arg Val Thr Gly Leu Tyr Leu Gly Thr Asp Glu Lys Val Thr Leu 
                805                 810                 815     

Thr Tyr Asn Val Arg Leu Asn Asp Glu Phe Val Ser Asn Lys Phe Tyr 
            820                 825                 830         

Asp Thr Asn Gly Arg Thr Thr Leu His Pro Lys Glu Val Glu Gln Asn 
        835                 840                 845             

Thr Val Arg Asp Phe Pro Ile Pro Lys Ile Arg Asp Val Arg Lys Tyr 
    850                 855                 860                 

Pro Glu Ile Thr Ile Ser Lys Glu Lys Lys Leu Gly Asp Ile Glu Phe 
865                 870                 875                 880 

Ile Lys Val Asn Lys Asn Asp Lys Lys Pro Leu Arg Gly Ala Val Phe 
                885                 890                 895     

Ser Leu Gln Lys Gln His Pro Asp Tyr Pro Asp Ile Tyr Gly Ala Ile 
            900                 905                 910         

Asp Gln Asn Gly Thr Tyr Gln Asn Val Arg Thr Gly Glu Asp Gly Lys 
        915                 920                 925             

Leu Thr Phe Lys Asn Leu Ser Asp Gly Lys Tyr Arg Leu Phe Glu Asn 
    930                 935                 940                 

Ser Glu Pro Ala Gly Tyr Lys Pro Val Gln Asn Lys Pro Ile Val Ala 
945                 950                 955                 960 

Phe Gln Ile Val Asn Gly Glu Val Arg Asp Val Thr Ser Ile Val Pro 
                965                 970                 975     

Gln Asp Ile Pro Ala Gly Tyr Glu Phe Thr Asn Asp Lys His Tyr Ile 
            980                 985                 990         

Thr Asn Glu Pro Ile Pro Pro Lys Arg Glu Leu Glu His His His His 
        995                 1000                1005            

His His 
    1010

<210>   208
<211>   2342
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Hybrid polypeptide

<400>   208
Met Val Ser Ala Gln Glu Ser Ser Thr Tyr Thr Val Lys Glu Gly Asp 
1               5                   10                  15      

Thr Leu Ser Glu Ile Ala Glu Thr His Asn Thr Thr Val Glu Lys Leu 
            20                  25                  30          

Ala Glu Asn Asn His Ile Asp Asn Ile His Leu Ile Tyr Val Asp Gln 
        35                  40                  45              

Glu Leu Val Ile Asp Gly Pro Val Ala Pro Val Ala Thr Pro Ala Pro 
    50                  55                  60                  

Ala Thr Tyr Ala Ala Pro Ala Ala Gln Asp Glu Thr Val Ser Ala Pro 
65                  70                  75                  80  

Val Ala Glu Thr Pro Val Val Ser Glu Thr Val Val Ser Thr Val Ser 
                85                  90                  95      

Gly Ser Glu Ala Glu Ala Lys Glu Trp Ile Ala Gln Lys Glu Ser Gly 
            100                 105                 110         

Gly Ser Tyr Thr Ala Thr Asn Gly Arg Tyr Ile Gly Arg Tyr Gln Leu 
        115                 120                 125             

Thr Asp Ser Tyr Leu Asn Gly Asp Tyr Ser Ala Glu Asn Gln Glu Arg 
    130                 135                 140                 

Val Ala Asp Ala Tyr Val Ala Gly Arg Tyr Gly Ser Trp Thr Ala Ala 
145                 150                 155                 160 

Lys Asn Phe Trp Leu Asn Asn Gly Trp Tyr Gly Ser Gly Ser Gly Gly 
                165                 170                 175     

Gly Gly Asp Glu Thr Leu Ile Thr His Thr Ala Glu Lys Pro Lys Glu 
            180                 185                 190         

Glu Lys Met Ile Val Glu Glu Lys Ala Asp Lys Ala Leu Glu Thr Lys 
        195                 200                 205             

Asn Ile Val Glu Arg Thr Glu Gln Ser Glu Pro Ser Ser Thr Glu Ala 
    210                 215                 220                 

Ile Ala Ser Glu Lys Lys Glu Asp Glu Ala Val Thr Pro Lys Glu Glu 
225                 230                 235                 240 

Lys Val Ser Ala Lys Pro Glu Glu Lys Ala Pro Arg Ile Glu Ser Gln 
                245                 250                 255     

Ala Ser Asn Gln Glu Lys Pro Leu Lys Glu Asp Ala Lys Ala Val Thr 
            260                 265                 270         

Asn Glu Glu Val Asn Gln Met Ile Glu Asp Arg Lys Val Asp Phe Asn 
        275                 280                 285             

Gln Asn Trp Tyr Phe Lys Leu Asn Ala Asn Ser Lys Glu Ala Ile Lys 
    290                 295                 300                 

Pro Asp Ala Asp Val Ser Thr Trp Lys Lys Leu Asp Leu Pro Tyr Asp 
305                 310                 315                 320 

Trp Ser Ile Phe Asn Asp Phe Asp His Glu Ser Pro Ala Gln Asn Glu 
                325                 330                 335     

Gly Gly Gln Leu Asn Gly Gly Glu Ala Trp Tyr Arg Lys Thr Phe Lys 
            340                 345                 350         

Leu Asp Glu Lys Asp Leu Lys Lys Asn Val Arg Leu Thr Phe Asp Gly 
        355                 360                 365             

Val Tyr Met Asp Ser Gln Val Tyr Val Asn Gly Gln Leu Val Gly His 
    370                 375                 380                 

Tyr Pro Asn Gly Tyr Asn Gln Phe Ser Tyr Asp Ile Thr Lys Tyr Leu 
385                 390                 395                 400 

Gln Lys Asp Gly Arg Glu Asn Val Ile Ala Val His Ala Val Asn Lys 
                405                 410                 415     

Gln Pro Ser Ser Arg Trp Tyr Ser Gly Ser Gly Ile Tyr Arg Asp Val 
            420                 425                 430         

Thr Leu Gln Val Thr Asp Lys Val His Val Glu Lys Asn Gly Thr Thr 
        435                 440                 445             

Ile Leu Thr Pro Lys Leu Glu Glu Gln Gln His Gly Lys Val Glu Thr 
    450                 455                 460                 

His Val Thr Ser Lys Ile Val Asn Thr Asp Asp Lys Asp His Glu Leu 
465                 470                 475                 480 

Val Ala Glu Tyr Gln Ile Val Glu Arg Gly Gly His Ala Val Thr Gly 
                485                 490                 495     

Leu Val Arg Thr Ala Ser Arg Thr Leu Lys Ala His Glu Ser Thr Ser 
            500                 505                 510         

Leu Asp Ala Ile Leu Glu Val Glu Arg Pro Lys Leu Trp Thr Val Leu 
        515                 520                 525             

Asn Asp Lys Pro Ala Leu Tyr Glu Leu Ile Thr Arg Val Tyr Arg Asp 
    530                 535                 540                 

Gly Gln Leu Val Asp Ala Lys Lys Asp Leu Phe Gly Tyr Arg Tyr Tyr 
545                 550                 555                 560 

His Trp Thr Pro Asn Glu Gly Phe Ser Leu Asn Gly Glu Arg Ile Lys 
                565                 570                 575     

Phe His Gly Val Ser Leu His His Asp His Gly Ala Leu Gly Ala Glu 
            580                 585                 590         

Glu Asn Tyr Lys Ala Glu Tyr Arg Arg Leu Lys Gln Met Lys Glu Met 
        595                 600                 605             

Gly Val Asn Ser Ile Arg Thr Thr His Asn Pro Ala Ser Glu Gln Thr 
    610                 615                 620                 

Leu Gln Ile Ala Ala Glu Leu Gly Leu Leu Val Gln Glu Glu Ala Phe 
625                 630                 635                 640 

Asp Thr Trp Tyr Gly Gly Lys Lys Pro Tyr Asp Tyr Gly Arg Phe Phe 
                645                 650                 655     

Glu Lys Asp Ala Thr His Pro Glu Ala Arg Lys Gly Glu Lys Trp Ser 
            660                 665                 670         

Asp Phe Asp Leu Arg Thr Met Val Glu Arg Gly Lys Asn Asn Pro Ala 
        675                 680                 685             

Ile Phe Met Trp Ser Ile Gly Asn Glu Ile Gly Glu Ala Asn Gly Asp 
    690                 695                 700                 

Ala His Ser Leu Ala Thr Val Lys Arg Leu Val Lys Val Ile Lys Asp 
705                 710                 715                 720 

Val Asp Lys Thr Arg Tyr Val Thr Met Gly Ala Asp Lys Phe Arg Phe 
                725                 730                 735     

Gly Asn Gly Ser Gly Gly His Glu Lys Ile Ala Asp Glu Leu Asp Ala 
            740                 745                 750         

Val Gly Phe Asn Tyr Ser Glu Asp Asn Tyr Lys Ala Leu Arg Ala Lys 
        755                 760                 765             

His Pro Lys Trp Leu Ile Tyr Gly Ser Glu Thr Ser Ser Ala Thr Arg 
    770                 775                 780                 

Thr Arg Gly Ser Tyr Tyr Arg Pro Glu Arg Glu Leu Lys His Ser Asn 
785                 790                 795                 800 

Gly Pro Glu Arg Asn Tyr Glu Gln Ser Asp Tyr Gly Asn Asp Arg Val 
                805                 810                 815     

Gly Trp Gly Lys Thr Ala Thr Ala Ser Trp Thr Phe Asp Arg Asp Asn 
            820                 825                 830         

Ala Gly Tyr Ala Gly Gln Phe Ile Trp Thr Gly Thr Asp Tyr Ile Gly 
        835                 840                 845             

Glu Pro Thr Pro Trp His Asn Gln Asn Gln Thr Pro Val Lys Ser Ser 
    850                 855                 860                 

Tyr Phe Gly Ile Val Asp Thr Ala Gly Ile Pro Lys His Asp Phe Tyr 
865                 870                 875                 880 

Leu Tyr Gln Ser Gln Trp Val Ser Val Lys Lys Lys Pro Met Val His 
                885                 890                 895     

Leu Leu Pro His Trp Asn Trp Glu Asn Lys Glu Leu Ala Ser Lys Val 
            900                 905                 910         

Ala Asp Ser Glu Gly Lys Ile Pro Val Arg Ala Tyr Ser Asn Ala Ser 
        915                 920                 925             

Ser Val Glu Leu Phe Leu Asn Gly Lys Ser Leu Gly Leu Lys Thr Phe 
    930                 935                 940                 

Asn Lys Lys Gln Thr Ser Asp Gly Arg Thr Tyr Gln Glu Gly Ala Asn 
945                 950                 955                 960 

Ala Asn Glu Leu Tyr Leu Glu Trp Lys Val Ala Tyr Gln Pro Gly Thr 
                965                 970                 975     

Leu Glu Ala Ile Ala Arg Asp Glu Ser Gly Lys Glu Ile Ala Arg Asp 
            980                 985                 990         

Lys Ile Thr Thr Ala Gly Lys Pro Ala Ala Val Arg Leu Ile Lys Glu 
        995                 1000                1005            

Asp His Ala Ile Ala Ala Asp Gly Lys Asp Leu Thr Tyr Ile Tyr Tyr 
    1010                1015                1020                

Glu Ile Val Asp Ser Gln Gly Asn Val Val Pro Thr Ala Asn Asn Leu 
1025                1030                1035                1040

Val Arg Phe Gln Leu His Gly Gln Gly Gln Leu Val Gly Val Asp Asn 
                1045                1050                1055    

Gly Glu Gln Ala Ser Arg Glu Arg Tyr Lys Ala Gln Ala Asp Gly Ser 
            1060                1065                1070        

Trp Ile Arg Lys Ala Phe Asn Gly Lys Gly Val Ala Ile Val Lys Ser 
        1075                1080                1085            

Thr Glu Gln Ala Gly Lys Phe Thr Leu Thr Ala His Ser Asp Leu Leu 
    1090                1095                1100                

Lys Ser Asn Gln Val Thr Val Phe Thr Gly Lys Lys Glu Gly Gln Glu 
1105                1110                1115                1120

Lys Thr Val Leu Gly Thr Glu Val Pro Lys Val Gln Thr Ile Ile Gly 
                1125                1130                1135    

Glu Ala Pro Glu Met Pro Thr Thr Val Pro Phe Val Tyr Ser Asp Gly 
            1140                1145                1150        

Ser Arg Ala Glu Arg Pro Val Thr Trp Ser Ser Val Asp Val Ser Lys 
        1155                1160                1165            

Pro Gly Ile Val Thr Val Lys Gly Met Ala Asp Gly Arg Glu Val Glu 
    1170                1175                1180                

Ala Arg Val Glu Val Ile Ala Leu Lys Ser Glu Leu Pro Val Val Lys 
1185                1190                1195                1200

Arg Ile Ala Pro Asn Thr Asp Leu Asn Ser Val Asp Lys Ser Val Ser 
                1205                1210                1215    

Tyr Val Leu Ile Asp Gly Ser Val Glu Glu Tyr Glu Val Asp Lys Trp 
            1220                1225                1230        

Glu Ile Ala Glu Glu Asp Lys Ala Lys Leu Ala Ile Pro Gly Ser Arg 
        1235                1240                1245            

Ile Gln Ala Thr Gly Tyr Leu Glu Gly Gln Pro Ile His Ala Thr Leu 
    1250                1255                1260                

Val Val Glu Glu Gly Asn Pro Ala Ala Pro Ala Val Pro Thr Val Thr 
1265                1270                1275                1280

Val Gly Gly Glu Ala Val Thr Gly Leu Thr Ser Gln Lys Pro Met Gln 
                1285                1290                1295    

Tyr Arg Thr Leu Ala Tyr Gly Ala Lys Leu Pro Glu Val Thr Ala Ser 
            1300                1305                1310        

Ala Lys Asn Ala Ala Val Thr Val Leu Gln Ala Ser Ala Ala Asn Gly 
        1315                1320                1325            

Met Arg Ala Ser Ile Phe Ile Gln Pro Lys Asp Gly Gly Pro Leu Gln 
    1330                1335                1340                

Thr Tyr Ala Ile Gln Phe Leu Glu Glu Ala Pro Lys Ile Ala His Leu 
1345                1350                1355                1360

Ser Leu Gln Val Glu Lys Ala Asp Ser Leu Lys Glu Asp Gln Thr Val 
                1365                1370                1375    

Lys Leu Ser Val Arg Ala His Tyr Gln Asp Gly Thr Gln Ala Val Leu 
            1380                1385                1390        

Pro Ala Asp Lys Val Thr Phe Ser Thr Ser Gly Glu Gly Glu Val Ala 
        1395                1400                1405            

Ile Arg Lys Gly Met Leu Glu Leu His Lys Pro Gly Ala Val Thr Leu 
    1410                1415                1420                

Asn Ala Glu Tyr Glu Gly Ala Lys Asp Gln Val Glu Leu Thr Ile Gln 
1425                1430                1435                1440

Ala Asn Thr Glu Lys Lys Ile Ala Gln Ser Ile Arg Pro Val Asn Val 
                1445                1450                1455    

Val Thr Asp Leu His Gln Glu Pro Ser Leu Pro Ala Thr Val Thr Val 
            1460                1465                1470        

Glu Tyr Asp Lys Gly Phe Pro Lys Thr His Lys Val Thr Trp Gln Ala 
        1475                1480                1485            

Ile Pro Lys Glu Lys Leu Asp Ser Tyr Gln Thr Phe Glu Val Leu Gly 
    1490                1495                1500                

Lys Val Glu Gly Ile Asp Leu Glu Ala Arg Ala Lys Val Ser Val Glu 
1505                1510                1515                1520

Gly Ile Val Ser Val Glu Glu Val Ser Val Thr Thr Pro Ile Ala Glu 
                1525                1530                1535    

Ala Pro Gln Leu Pro Glu Ser Val Arg Thr Tyr Asp Ser Asn Gly His 
            1540                1545                1550        

Val Ser Ser Ala Lys Val Ala Trp Asp Ala Ile Arg Pro Glu Gln Tyr 
        1555                1560                1565            

Ala Lys Glu Gly Val Phe Thr Val Asn Gly Arg Leu Glu Gly Thr Gln 
    1570                1575                1580                

Leu Thr Thr Lys Leu His Val Arg Val Ser Ala Gln Thr Glu Gln Gly 
1585                1590                1595                1600

Ala Asn Ile Ser Asp Gln Trp Thr Gly Ser Glu Leu Pro Leu Ala Phe 
                1605                1610                1615    

Ala Ser Asp Ser Asn Pro Ser Asp Pro Val Ser Asn Val Asn Asp Lys 
            1620                1625                1630        

Leu Ile Ser Tyr Asn Asn Gln Pro Ala Asn Arg Trp Thr Asn Trp Asn 
        1635                1640                1645            

Arg Thr Asn Pro Glu Ala Ser Val Gly Val Leu Phe Gly Asp Ser Gly 
    1650                1655                1660                

Ile Leu Ser Lys Arg Ser Val Asp Asn Leu Ser Val Gly Phe His Glu 
1665                1670                1675                1680

Asp His Gly Val Gly Val Pro Lys Ser Tyr Val Ile Glu Tyr Tyr Val 
                1685                1690                1695    

Gly Lys Thr Val Pro Thr Ala Pro Lys Asn Pro Ser Phe Val Gly Asn 
            1700                1705                1710        

Glu Asp His Val Phe Asn Asp Ser Ala Asn Trp Lys Pro Val Thr Asn 
        1715                1720                1725            

Leu Lys Ala Pro Ala Gln Leu Lys Ala Gly Glu Met Asn His Phe Ser 
    1730                1735                1740                

Phe Asp Lys Val Glu Thr Tyr Ala Val Arg Ile Arg Met Val Lys Ala 
1745                1750                1755                1760

Asp Asn Lys Arg Gly Thr Ser Ile Thr Glu Val Gln Ile Phe Ala Lys 
                1765                1770                1775    

Gln Val Ala Ala Ala Lys Gln Gly Gln Thr Arg Ile Gln Val Asp Gly 
            1780                1785                1790        

Lys Asp Leu Ala Asn Phe Asn Pro Asp Leu Thr Asp Tyr Tyr Leu Glu 
        1795                1800                1805            

Ser Val Asp Gly Lys Val Pro Ala Val Thr Ala Ser Val Ser Asn Asn 
    1810                1815                1820                

Gly Leu Ala Thr Val Val Pro Ser Val Arg Glu Gly Glu Pro Val Arg 
1825                1830                1835                1840

Val Ile Ala Lys Ala Glu Asn Gly Asp Ile Leu Gly Glu Tyr Arg Leu 
                1845                1850                1855    

His Phe Thr Lys Asp Lys Ser Leu Leu Ser His Lys Pro Val Ala Ala 
            1860                1865                1870        

Val Lys Gln Ala Arg Leu Leu Gln Val Gly Gln Ala Leu Glu Leu Pro 
        1875                1880                1885            

Thr Lys Val Pro Val Tyr Phe Thr Gly Lys Asp Gly Tyr Glu Thr Lys 
    1890                1895                1900                

Asp Leu Thr Val Glu Trp Glu Glu Val Pro Ala Glu Asn Leu Thr Lys 
1905                1910                1915                1920

Ala Gly Gln Phe Thr Val Arg Gly Arg Val Leu Gly Ser Asn Leu Val 
                1925                1930                1935    

Ala Glu Ile Thr Val Arg Val Thr Asp Lys Leu Gly Glu Thr Leu Ser 
            1940                1945                1950        

Asp Asn Pro Asn Tyr Asp Glu Asn Ser Asn Gln Ala Phe Ala Ser Ala 
        1955                1960                1965            

Thr Asn Asp Ile Asp Lys Asn Ser His Asp Arg Val Asp Tyr Leu Asn 
    1970                1975                1980                

Asp Gly Asp His Ser Glu Asn Arg Arg Trp Thr Asn Trp Ser Pro Thr 
1985                1990                1995                2000

Pro Ser Ser Asn Pro Glu Val Ser Ala Gly Val Ile Phe Arg Glu Asn 
                2005                2010                2015    

Gly Lys Ile Val Glu Arg Thr Val Thr Gln Gly Lys Val Gln Phe Phe 
            2020                2025                2030        

Ala Asp Ser Gly Thr Asp Ala Pro Ser Lys Leu Val Leu Glu Arg Tyr 
        2035                2040                2045            

Val Gly Pro Glu Phe Glu Val Pro Thr Tyr Tyr Ser Asn Tyr Gln Ala 
    2050                2055                2060                

Tyr Asp Ala Asp His Pro Phe Asn Asn Pro Glu Asn Trp Glu Ala Val 
2065                2070                2075                2080

Pro Tyr Arg Ala Asp Lys Asp Ile Ala Ala Gly Asp Glu Ile Asn Val 
                2085                2090                2095    

Thr Phe Lys Ala Ile Lys Ala Lys Ala Met Arg Trp Arg Met Glu Arg 
            2100                2105                2110        

Lys Ala Asp Lys Ser Gly Val Ala Met Ile Glu Met Thr Phe Leu Ala 
        2115                2120                2125            

Pro Ser Glu Leu Pro Gln Glu Ser Thr Gln Ser Lys Ile Leu Val Asp 
    2130                2135                2140                

Gly Lys Glu Leu Ala Asp Phe Ala Glu Asn Arg Gln Asp Tyr Gln Ile 
2145                2150                2155                2160

Thr Tyr Lys Gly Gln Arg Pro Lys Val Ser Val Glu Glu Asn Asn Gln 
                2165                2170                2175    

Val Ala Ser Thr Val Val Asp Ser Gly Glu Asp Ser Phe Pro Val Leu 
            2180                2185                2190        

Val Arg Leu Val Ser Glu Ser Gly Lys Gln Val Lys Glu Tyr Arg Ile 
        2195                2200                2205            

His Leu Thr Lys Glu Lys Pro Val Ser Glu Lys Thr Val Ala Ala Val 
    2210                2215                2220                

Gln Glu Asp Leu Pro Lys Ile Glu Phe Val Glu Lys Asp Leu Ala Tyr 
2225                2230                2235                2240

Lys Thr Val Glu Lys Lys Asp Ser Thr Leu Tyr Leu Gly Glu Thr Arg 
                2245                2250                2255    

Val Glu Gln Glu Gly Lys Val Gly Lys Glu Arg Ile Phe Thr Ala Ile 
            2260                2265                2270        

Asn Pro Asp Gly Ser Lys Glu Glu Lys Leu Arg Glu Val Val Glu Val 
        2275                2280                2285            

Pro Thr Asp Arg Ile Val Leu Val Gly Thr Lys Pro Val Ala Gln Glu 
    2290                2295                2300                

Ala Lys Lys Pro Gln Val Ser Glu Lys Ala Asp Thr Lys Pro Ile Asp 
2305                2310                2315                2320

Ser Ser Glu Ala Ser Gln Thr Asn Lys Ala Gln Ala Ala Ala Leu Glu 
                2325                2330                2335    

His His His His His His 
            2340        

<210>   209
<211>   1252
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Hybrid polypeptide

<400>   209
Met Val Ser Ala Gln Glu Ser Ser Thr Tyr Thr Val Lys Glu Gly Asp 
1               5                   10                  15      

Thr Leu Ser Glu Ile Ala Glu Thr His Asn Thr Thr Val Glu Lys Leu 
            20                  25                  30          

Ala Glu Asn Asn His Ile Asp Asn Ile His Leu Ile Tyr Val Asp Gln 
        35                  40                  45              

Glu Leu Val Ile Asp Gly Pro Val Ala Pro Val Ala Thr Pro Ala Pro 
    50                  55                  60                  

Ala Thr Tyr Ala Ala Pro Ala Ala Gln Asp Glu Thr Val Ser Ala Pro 
65                  70                  75                  80  

Val Ala Glu Thr Pro Val Val Ser Glu Thr Val Val Ser Thr Val Ser 
                85                  90                  95      

Gly Ser Glu Ala Glu Ala Lys Glu Trp Ile Ala Gln Lys Glu Ser Gly 
            100                 105                 110         

Gly Ser Tyr Thr Ala Thr Asn Gly Arg Tyr Ile Gly Arg Tyr Gln Leu 
        115                 120                 125             

Thr Asp Ser Tyr Leu Asn Gly Asp Tyr Ser Ala Glu Asn Gln Glu Arg 
    130                 135                 140                 

Val Ala Asp Ala Tyr Val Ala Gly Arg Tyr Gly Ser Trp Thr Ala Ala 
145                 150                 155                 160 

Lys Asn Phe Trp Leu Asn Asn Gly Trp Tyr Gly Ser Gly Ser Gly Gly 
                165                 170                 175     

Gly Gly Asp Glu Thr Leu Ile Thr His Thr Ala Glu Lys Pro Lys Glu 
            180                 185                 190         

Glu Lys Met Ile Val Glu Glu Lys Ala Asp Lys Ala Leu Glu Thr Lys 
        195                 200                 205             

Asn Ile Val Glu Arg Thr Glu Gln Ser Glu Pro Ser Ser Thr Glu Ala 
    210                 215                 220                 

Ile Ala Ser Glu Lys Lys Glu Asp Glu Ala Val Thr Pro Lys Glu Glu 
225                 230                 235                 240 

Lys Val Ser Ala Lys Pro Glu Glu Lys Ala Pro Arg Ile Glu Ser Gln 
                245                 250                 255     

Ala Ser Asn Gln Glu Lys Pro Leu Lys Glu Asp Ala Lys Ala Val Thr 
            260                 265                 270         

Asn Glu Glu Val Asn Gln Met Ile Glu Asp Arg Lys Val Asp Phe Asn 
        275                 280                 285             

Gln Asn Trp Tyr Phe Lys Leu Asn Ala Asn Ser Lys Glu Ala Ile Lys 
    290                 295                 300                 

Pro Asp Ala Asp Val Ser Thr Trp Lys Lys Leu Asp Leu Pro Tyr Asp 
305                 310                 315                 320 

Trp Ser Ile Phe Asn Asp Phe Asp His Glu Ser Pro Ala Gln Asn Glu 
                325                 330                 335     

Gly Gly Gln Leu Asn Gly Gly Glu Ala Trp Tyr Arg Lys Thr Phe Lys 
            340                 345                 350         

Leu Asp Glu Lys Asp Leu Lys Lys Asn Val Arg Leu Thr Phe Asp Gly 
        355                 360                 365             

Val Tyr Met Asp Ser Gln Val Tyr Val Asn Gly Gln Leu Val Gly His 
    370                 375                 380                 

Tyr Pro Asn Gly Tyr Asn Gln Phe Ser Tyr Asp Ile Thr Lys Tyr Leu 
385                 390                 395                 400 

Gln Lys Asp Gly Arg Glu Asn Val Ile Ala Val His Ala Val Asn Lys 
                405                 410                 415     

Gln Pro Ser Ser Arg Trp Tyr Ser Gly Ser Gly Ile Tyr Arg Asp Val 
            420                 425                 430         

Thr Leu Gln Val Thr Asp Lys Val His Val Glu Lys Asn Gly Thr Thr 
        435                 440                 445             

Ile Leu Thr Pro Lys Leu Glu Glu Gln Gln His Gly Lys Val Glu Thr 
    450                 455                 460                 

His Val Thr Ser Lys Ile Val Asn Thr Asp Asp Lys Asp His Glu Leu 
465                 470                 475                 480 

Val Ala Glu Tyr Gln Ile Val Glu Arg Gly Gly His Ala Val Thr Gly 
                485                 490                 495     

Leu Val Arg Thr Ala Ser Arg Thr Leu Lys Ala His Glu Ser Thr Ser 
            500                 505                 510         

Leu Asp Ala Ile Leu Glu Val Glu Arg Pro Lys Leu Trp Thr Val Leu 
        515                 520                 525             

Asn Asp Lys Pro Ala Leu Tyr Glu Leu Ile Thr Arg Val Tyr Arg Asp 
    530                 535                 540                 

Gly Gln Leu Val Asp Ala Lys Lys Asp Leu Phe Gly Tyr Arg Tyr Tyr 
545                 550                 555                 560 

His Trp Thr Pro Asn Glu Gly Phe Ser Leu Asn Gly Glu Arg Ile Lys 
                565                 570                 575     

Phe His Gly Val Ser Leu His His Asp His Gly Ala Leu Gly Ala Glu 
            580                 585                 590         

Glu Asn Tyr Lys Ala Glu Tyr Arg Arg Leu Lys Gln Met Lys Glu Met 
        595                 600                 605             

Gly Val Asn Ser Ile Arg Thr Thr His Asn Pro Ala Ser Glu Gln Thr 
    610                 615                 620                 

Leu Gln Ile Ala Ala Glu Leu Gly Leu Leu Val Gln Glu Glu Ala Phe 
625                 630                 635                 640 

Asp Thr Trp Tyr Gly Gly Lys Lys Pro Tyr Asp Tyr Gly Arg Phe Phe 
                645                 650                 655     

Glu Lys Asp Ala Thr His Pro Glu Ala Arg Lys Gly Glu Lys Trp Ser 
            660                 665                 670         

Asp Phe Asp Leu Arg Thr Met Val Glu Arg Gly Lys Asn Asn Pro Ala 
        675                 680                 685             

Ile Phe Met Trp Ser Ile Gly Asn Glu Ile Gly Glu Ala Asn Gly Asp 
    690                 695                 700                 

Ala His Ser Leu Ala Thr Val Lys Arg Leu Val Lys Val Ile Lys Asp 
705                 710                 715                 720 

Val Asp Lys Thr Arg Tyr Val Thr Met Gly Ala Asp Lys Phe Arg Phe 
                725                 730                 735     

Gly Asn Gly Ser Gly Gly His Glu Lys Ile Ala Asp Glu Leu Asp Ala 
            740                 745                 750         

Val Gly Phe Asn Tyr Ser Glu Asp Asn Tyr Lys Ala Leu Arg Ala Lys 
        755                 760                 765             

His Pro Lys Trp Leu Ile Tyr Gly Ser Glu Thr Ser Ser Ala Thr Arg 
    770                 775                 780                 

Thr Arg Gly Ser Tyr Tyr Arg Pro Glu Arg Glu Leu Lys His Ser Asn 
785                 790                 795                 800 

Gly Pro Glu Arg Asn Tyr Glu Gln Ser Asp Tyr Gly Asn Asp Arg Val 
                805                 810                 815     

Gly Trp Gly Lys Thr Ala Thr Ala Ser Trp Thr Phe Asp Arg Asp Asn 
            820                 825                 830         

Ala Gly Tyr Ala Gly Gln Phe Ile Trp Thr Gly Thr Asp Tyr Ile Gly 
        835                 840                 845             

Glu Pro Thr Pro Trp His Asn Gln Asn Gln Thr Pro Val Lys Ser Ser 
    850                 855                 860                 

Tyr Phe Gly Ile Val Asp Thr Ala Gly Ile Pro Lys His Asp Phe Tyr 
865                 870                 875                 880 

Leu Tyr Gln Ser Gln Trp Val Ser Val Lys Lys Lys Pro Met Val His 
                885                 890                 895     

Leu Leu Pro His Trp Asn Trp Glu Asn Lys Glu Leu Ala Ser Lys Val 
            900                 905                 910         

Ala Asp Ser Glu Gly Lys Ile Pro Val Arg Ala Tyr Ser Asn Ala Ser 
        915                 920                 925             

Ser Val Glu Leu Phe Leu Asn Gly Lys Ser Leu Gly Leu Lys Thr Phe 
    930                 935                 940                 

Asn Lys Lys Gln Thr Ser Asp Gly Arg Thr Tyr Gln Glu Gly Ala Asn 
945                 950                 955                 960 

Ala Asn Glu Leu Tyr Leu Glu Trp Lys Val Ala Tyr Gln Pro Gly Thr 
                965                 970                 975     

Leu Glu Ala Ile Ala Arg Asp Glu Ser Gly Lys Glu Ile Ala Arg Asp 
            980                 985                 990         

Lys Ile Thr Thr Ala Gly Lys Pro Ala Ala Val Arg Leu Ile Lys Glu 
        995                 1000                1005            

Asp His Ala Ile Ala Ala Asp Gly Lys Asp Leu Thr Tyr Ile Tyr Tyr 
    1010                1015                1020                

Glu Ile Val Asp Ser Gln Gly Asn Val Val Pro Thr Ala Asn Asn Leu 
1025                1030                1035                1040

Val Arg Phe Gln Leu His Gly Gln Gly Gln Leu Val Gly Val Asp Asn 
                1045                1050                1055    

Gly Glu Gln Ala Ser Arg Glu Arg Tyr Lys Ala Gln Ala Asp Gly Ser 
            1060                1065                1070        

Trp Ile Arg Lys Ala Phe Asn Gly Lys Gly Val Ala Ile Val Lys Ser 
        1075                1080                1085            

Thr Glu Gln Ala Gly Lys Phe Thr Leu Thr Ala His Ser Asp Leu Leu 
    1090                1095                1100                

Lys Ser Asn Gln Val Thr Val Phe Thr Gly Lys Lys Glu Gly Gln Glu 
1105                1110                1115                1120

Lys Thr Val Leu Gly Thr Glu Val Pro Lys Val Gln Thr Ile Ile Gly 
                1125                1130                1135    

Glu Ala Pro Glu Met Pro Thr Thr Val Pro Phe Val Tyr Ser Asp Gly 
            1140                1145                1150        

Ser Arg Ala Glu Arg Pro Val Thr Trp Ser Ser Val Asp Val Ser Lys 
        1155                1160                1165            

Pro Gly Ile Val Thr Val Lys Gly Met Ala Asp Gly Arg Glu Val Glu 
    1170                1175                1180                

Ala Arg Val Glu Val Ile Ala Leu Lys Ser Glu Leu Pro Val Val Lys 
1185                1190                1195                1200

Arg Ile Ala Pro Asn Thr Asp Leu Asn Ser Val Asp Lys Ser Val Ser 
                1205                1210                1215    

Tyr Val Leu Ile Asp Gly Ser Val Glu Glu Tyr Glu Val Asp Lys Trp 
            1220                1225                1230        

Glu Ile Ala Glu Glu Asp Lys Ala Lys Ala Ala Ala Leu Glu His His 
        1235                1240                1245            

His His His His 
    1250        

<210>   210
<211>   1287
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Hybrid polypeptide

<400>   210
Met Val Ser Ala Gln Glu Ser Ser Thr Tyr Thr Val Lys Glu Gly Asp 
1               5                   10                  15      

Thr Leu Ser Glu Ile Ala Glu Thr His Asn Thr Thr Val Glu Lys Leu 
            20                  25                  30          

Ala Glu Asn Asn His Ile Asp Asn Ile His Leu Ile Tyr Val Asp Gln 
        35                  40                  45              

Glu Leu Val Ile Asp Gly Pro Val Ala Pro Val Ala Thr Pro Ala Pro 
    50                  55                  60                  

Ala Thr Tyr Ala Ala Pro Ala Ala Gln Asp Glu Thr Val Ser Ala Pro 
65                  70                  75                  80  

Val Ala Glu Thr Pro Val Val Ser Glu Thr Val Val Ser Thr Val Ser 
                85                  90                  95      

Gly Ser Glu Ala Glu Ala Lys Glu Trp Ile Ala Gln Lys Glu Ser Gly 
            100                 105                 110         

Gly Ser Tyr Thr Ala Thr Asn Gly Arg Tyr Ile Gly Arg Tyr Gln Leu 
        115                 120                 125             

Thr Asp Ser Tyr Leu Asn Gly Asp Tyr Ser Ala Glu Asn Gln Glu Arg 
    130                 135                 140                 

Val Ala Asp Ala Tyr Val Ala Gly Arg Tyr Gly Ser Trp Thr Ala Ala 
145                 150                 155                 160 

Lys Asn Phe Trp Leu Asn Asn Gly Trp Tyr Gly Ser Gly Ser Gly Gly 
                165                 170                 175     

Gly Gly Ile Ala Glu Glu Asp Lys Ala Lys Leu Ala Ile Pro Gly Ser 
            180                 185                 190         

Arg Ile Gln Ala Thr Gly Tyr Leu Glu Gly Gln Pro Ile His Ala Thr 
        195                 200                 205             

Leu Val Val Glu Glu Gly Asn Pro Ala Ala Pro Ala Val Pro Thr Val 
    210                 215                 220                 

Thr Val Gly Gly Glu Ala Val Thr Gly Leu Thr Ser Gln Lys Pro Met 
225                 230                 235                 240 

Gln Tyr Arg Thr Leu Ala Tyr Gly Ala Lys Leu Pro Glu Val Thr Ala 
                245                 250                 255     

Ser Ala Lys Asn Ala Ala Val Thr Val Leu Gln Ala Ser Ala Ala Asn 
            260                 265                 270         

Gly Met Arg Ala Ser Ile Phe Ile Gln Pro Lys Asp Gly Gly Pro Leu 
        275                 280                 285             

Gln Thr Tyr Ala Ile Gln Phe Leu Glu Glu Ala Pro Lys Ile Ala His 
    290                 295                 300                 

Leu Ser Leu Gln Val Glu Lys Ala Asp Ser Leu Lys Glu Asp Gln Thr 
305                 310                 315                 320 

Val Lys Leu Ser Val Arg Ala His Tyr Gln Asp Gly Thr Gln Ala Val 
                325                 330                 335     

Leu Pro Ala Asp Lys Val Thr Phe Ser Thr Ser Gly Glu Gly Glu Val 
            340                 345                 350         

Ala Ile Arg Lys Gly Met Leu Glu Leu His Lys Pro Gly Ala Val Thr 
        355                 360                 365             

Leu Asn Ala Glu Tyr Glu Gly Ala Lys Asp Gln Val Glu Leu Thr Ile 
    370                 375                 380                 

Gln Ala Asn Thr Glu Lys Lys Ile Ala Gln Ser Ile Arg Pro Val Asn 
385                 390                 395                 400 

Val Val Thr Asp Leu His Gln Glu Pro Ser Leu Pro Ala Thr Val Thr 
                405                 410                 415     

Val Glu Tyr Asp Lys Gly Phe Pro Lys Thr His Lys Val Thr Trp Gln 
            420                 425                 430         

Ala Ile Pro Lys Glu Lys Leu Asp Ser Tyr Gln Thr Phe Glu Val Leu 
        435                 440                 445             

Gly Lys Val Glu Gly Ile Asp Leu Glu Ala Arg Ala Lys Val Ser Val 
    450                 455                 460                 

Glu Gly Ile Val Ser Val Glu Glu Val Ser Val Thr Thr Pro Ile Ala 
465                 470                 475                 480 

Glu Ala Pro Gln Leu Pro Glu Ser Val Arg Thr Tyr Asp Ser Asn Gly 
                485                 490                 495     

His Val Ser Ser Ala Lys Val Ala Trp Asp Ala Ile Arg Pro Glu Gln 
            500                 505                 510         

Tyr Ala Lys Glu Gly Val Phe Thr Val Asn Gly Arg Leu Glu Gly Thr 
        515                 520                 525             

Gln Leu Thr Thr Lys Leu His Val Arg Val Ser Ala Gln Thr Glu Gln 
    530                 535                 540                 

Gly Ala Asn Ile Ser Asp Gln Trp Thr Gly Ser Glu Leu Pro Leu Ala 
545                 550                 555                 560 

Phe Ala Ser Asp Ser Asn Pro Ser Asp Pro Val Ser Asn Val Asn Asp 
                565                 570                 575     

Lys Leu Ile Ser Tyr Asn Asn Gln Pro Ala Asn Arg Trp Thr Asn Trp 
            580                 585                 590         

Asn Arg Thr Asn Pro Glu Ala Ser Val Gly Val Leu Phe Gly Asp Ser 
        595                 600                 605             

Gly Ile Leu Ser Lys Arg Ser Val Asp Asn Leu Ser Val Gly Phe His 
    610                 615                 620                 

Glu Asp His Gly Val Gly Val Pro Lys Ser Tyr Val Ile Glu Tyr Tyr 
625                 630                 635                 640 

Val Gly Lys Thr Val Pro Thr Ala Pro Lys Asn Pro Ser Phe Val Gly 
                645                 650                 655     

Asn Glu Asp His Val Phe Asn Asp Ser Ala Asn Trp Lys Pro Val Thr 
            660                 665                 670         

Asn Leu Lys Ala Pro Ala Gln Leu Lys Ala Gly Glu Met Asn His Phe 
        675                 680                 685             

Ser Phe Asp Lys Val Glu Thr Tyr Ala Val Arg Ile Arg Met Val Lys 
    690                 695                 700                 

Ala Asp Asn Lys Arg Gly Thr Ser Ile Thr Glu Val Gln Ile Phe Ala 
705                 710                 715                 720 

Lys Gln Val Ala Ala Ala Lys Gln Gly Gln Thr Arg Ile Gln Val Asp 
                725                 730                 735     

Gly Lys Asp Leu Ala Asn Phe Asn Pro Asp Leu Thr Asp Tyr Tyr Leu 
            740                 745                 750         

Glu Ser Val Asp Gly Lys Val Pro Ala Val Thr Ala Ser Val Ser Asn 
        755                 760                 765             

Asn Gly Leu Ala Thr Val Val Pro Ser Val Arg Glu Gly Glu Pro Val 
    770                 775                 780                 

Arg Val Ile Ala Lys Ala Glu Asn Gly Asp Ile Leu Gly Glu Tyr Arg 
785                 790                 795                 800 

Leu His Phe Thr Lys Asp Lys Ser Leu Leu Ser His Lys Pro Val Ala 
                805                 810                 815     

Ala Val Lys Gln Ala Arg Leu Leu Gln Val Gly Gln Ala Leu Glu Leu 
            820                 825                 830         

Pro Thr Lys Val Pro Val Tyr Phe Thr Gly Lys Asp Gly Tyr Glu Thr 
        835                 840                 845             

Lys Asp Leu Thr Val Glu Trp Glu Glu Val Pro Ala Glu Asn Leu Thr 
    850                 855                 860                 

Lys Ala Gly Gln Phe Thr Val Arg Gly Arg Val Leu Gly Ser Asn Leu 
865                 870                 875                 880 

Val Ala Glu Ile Thr Val Arg Val Thr Asp Lys Leu Gly Glu Thr Leu 
                885                 890                 895     

Ser Asp Asn Pro Asn Tyr Asp Glu Asn Ser Asn Gln Ala Phe Ala Ser 
            900                 905                 910         

Ala Thr Asn Asp Ile Asp Lys Asn Ser His Asp Arg Val Asp Tyr Leu 
        915                 920                 925             

Asn Asp Gly Asp His Ser Glu Asn Arg Arg Trp Thr Asn Trp Ser Pro 
    930                 935                 940                 

Thr Pro Ser Ser Asn Pro Glu Val Ser Ala Gly Val Ile Phe Arg Glu 
945                 950                 955                 960 

Asn Gly Lys Ile Val Glu Arg Thr Val Thr Gln Gly Lys Val Gln Phe 
                965                 970                 975     

Phe Ala Asp Ser Gly Thr Asp Ala Pro Ser Lys Leu Val Leu Glu Arg 
            980                 985                 990         

Tyr Val Gly Pro Glu Phe Glu Val Pro Thr Tyr Tyr Ser Asn Tyr Gln 
        995                 1000                1005            

Ala Tyr Asp Ala Asp His Pro Phe Asn Asn Pro Glu Asn Trp Glu Ala 
    1010                1015                1020                

Val Pro Tyr Arg Ala Asp Lys Asp Ile Ala Ala Gly Asp Glu Ile Asn 
1025                1030                1035                1040

Val Thr Phe Lys Ala Ile Lys Ala Lys Ala Met Arg Trp Arg Met Glu 
                1045                1050                1055    

Arg Lys Ala Asp Lys Ser Gly Val Ala Met Ile Glu Met Thr Phe Leu 
            1060                1065                1070        

Ala Pro Ser Glu Leu Pro Gln Glu Ser Thr Gln Ser Lys Ile Leu Val 
        1075                1080                1085            

Asp Gly Lys Glu Leu Ala Asp Phe Ala Glu Asn Arg Gln Asp Tyr Gln 
    1090                1095                1100                

Ile Thr Tyr Lys Gly Gln Arg Pro Lys Val Ser Val Glu Glu Asn Asn 
1105                1110                1115                1120

Gln Val Ala Ser Thr Val Val Asp Ser Gly Glu Asp Ser Phe Pro Val 
                1125                1130                1135    

Leu Val Arg Leu Val Ser Glu Ser Gly Lys Gln Val Lys Glu Tyr Arg 
            1140                1145                1150        

Ile His Leu Thr Lys Glu Lys Pro Val Ser Glu Lys Thr Val Ala Ala 
        1155                1160                1165            

Val Gln Glu Asp Leu Pro Lys Ile Glu Phe Val Glu Lys Asp Leu Ala 
    1170                1175                1180                

Tyr Lys Thr Val Glu Lys Lys Asp Ser Thr Leu Tyr Leu Gly Glu Thr 
1185                1190                1195                1200

Arg Val Glu Gln Glu Gly Lys Val Gly Lys Glu Arg Ile Phe Thr Ala 
                1205                1210                1215    

Ile Asn Pro Asp Gly Ser Lys Glu Glu Lys Leu Arg Glu Val Val Glu 
            1220                1225                1230        

Val Pro Thr Asp Arg Ile Val Leu Val Gly Thr Lys Pro Val Ala Gln 
        1235                1240                1245            

Glu Ala Lys Lys Pro Gln Val Ser Glu Lys Ala Asp Thr Lys Pro Ile 
    1250                1255                1260                

Asp Ser Ser Glu Ala Ser Gln Thr Asn Lys Ala Gln Ala Ala Ala Leu 
1265                1270                1275                1280

Glu His His His His His His 
                1285        

<210>   211
<211>   1212
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Hybrid polypeptide

<400>   211
Met Ala Ser Glu Thr Pro Glu Thr Ser Pro Ala Ile Gly Lys Val Val 
1               5                   10                  15      

Ile Lys Glu Thr Gly Glu Gly Gly Ala Leu Leu Gly Asp Ala Val Phe 
            20                  25                  30          

Glu Leu Lys Asn Asn Thr Asp Gly Thr Thr Val Ser Gln Arg Thr Glu 
        35                  40                  45              

Ala Gln Thr Gly Glu Ala Ile Phe Ser Asn Ile Lys Pro Gly Thr Tyr 
    50                  55                  60                  

Thr Leu Thr Glu Ala Gln Pro Pro Val Gly Tyr Lys Pro Ser Thr Lys 
65                  70                  75                  80  

Gln Trp Thr Val Glu Val Glu Lys Asn Gly Arg Thr Thr Val Gln Gly 
                85                  90                  95      

Glu Gln Val Glu Asn Arg Glu Glu Ala Leu Ser Asp Gln Tyr Pro Gln 
            100                 105                 110         

Thr Gly Thr Tyr Pro Asp Val Gln Thr Pro Tyr Gln Ile Ile Lys Val 
        115                 120                 125             

Asp Gly Ser Glu Lys Asn Gly Gln His Lys Ala Leu Asn Pro Asn Pro 
    130                 135                 140                 

Tyr Glu Arg Val Ile Pro Glu Gly Thr Leu Ser Lys Arg Ile Tyr Gln 
145                 150                 155                 160 

Val Asn Asn Leu Asp Asp Asn Gln Tyr Gly Ile Glu Leu Thr Val Ser 
                165                 170                 175     

Gly Lys Thr Val Tyr Glu Gln Lys Asp Lys Ser Val Pro Leu Asp Val 
            180                 185                 190         

Val Ile Leu Leu Asp Asn Ser Asn Ser Met Ser Asn Ile Arg Asn Lys 
        195                 200                 205             

Asn Ala Arg Arg Ala Glu Arg Ala Gly Glu Ala Thr Arg Ser Leu Ile 
    210                 215                 220                 

Asp Lys Ile Thr Ser Asp Ser Glu Asn Arg Val Ala Leu Val Thr Tyr 
225                 230                 235                 240 

Ala Ser Thr Ile Phe Asp Gly Thr Glu Phe Thr Val Glu Lys Gly Val 
                245                 250                 255     

Ala Asp Lys Asn Gly Lys Arg Leu Asn Asp Ser Leu Phe Trp Asn Tyr 
            260                 265                 270         

Asp Gln Thr Ser Phe Thr Thr Asn Thr Lys Asp Tyr Ser Tyr Leu Lys 
        275                 280                 285             

Leu Thr Asn Asp Lys Asn Asp Ile Val Glu Leu Lys Asn Lys Val Pro 
    290                 295                 300                 

Thr Glu Ala Glu Asp His Asp Gly Asn Arg Leu Met Tyr Gln Phe Gly 
305                 310                 315                 320 

Ala Thr Phe Thr Gln Lys Ala Leu Met Lys Ala Asp Glu Ile Leu Thr 
                325                 330                 335     

Gln Gln Ala Arg Gln Asn Ser Gln Lys Val Ile Phe His Ile Thr Asp 
            340                 345                 350         

Gly Val Pro Thr Met Ser Tyr Pro Ile Asn Phe Asn His Ala Thr Phe 
        355                 360                 365             

Ala Pro Ser Tyr Gln Asn Gln Leu Asn Ala Phe Phe Ser Lys Ser Pro 
    370                 375                 380                 

Asn Lys Asp Gly Ile Leu Leu Ser Asp Phe Ile Thr Gln Ala Thr Ser 
385                 390                 395                 400 

Gly Glu His Thr Ile Val Arg Gly Asp Gly Gln Ser Tyr Gln Met Phe 
                405                 410                 415     

Thr Asp Lys Thr Val Tyr Glu Lys Gly Ala Pro Ala Ala Phe Pro Val 
            420                 425                 430         

Lys Pro Glu Lys Tyr Ser Glu Met Lys Ala Ala Gly Tyr Ala Val Ile 
        435                 440                 445             

Gly Asp Pro Ile Asn Gly Gly Tyr Ile Trp Leu Asn Trp Arg Glu Ser 
    450                 455                 460                 

Ile Leu Ala Tyr Pro Phe Asn Ser Asn Thr Ala Lys Ile Thr Asn His 
465                 470                 475                 480 

Gly Asp Pro Thr Arg Trp Tyr Tyr Asn Gly Asn Ile Ala Pro Asp Gly 
                485                 490                 495     

Tyr Asp Val Phe Thr Val Gly Ile Gly Ile Asn Gly Asp Pro Gly Thr 
            500                 505                 510         

Asp Glu Ala Thr Ala Thr Ser Phe Met Gln Ser Ile Ser Ser Lys Pro 
        515                 520                 525             

Glu Asn Tyr Thr Asn Val Thr Asp Thr Thr Lys Ile Leu Glu Gln Leu 
    530                 535                 540                 

Asn Arg Tyr Phe His Thr Ile Val Thr Glu Lys Lys Ser Ile Glu Asn 
545                 550                 555                 560 

Gly Thr Ile Thr Asp Pro Met Gly Glu Leu Ile Asp Leu Gln Leu Gly 
                565                 570                 575     

Thr Asp Gly Arg Phe Asp Pro Ala Asp Tyr Thr Leu Thr Ala Asn Asp 
            580                 585                 590         

Gly Ser Arg Leu Glu Asn Gly Gln Ala Val Gly Gly Pro Gln Asn Asp 
        595                 600                 605             

Gly Gly Leu Leu Lys Asn Ala Lys Val Leu Tyr Asp Thr Thr Glu Lys 
    610                 615                 620                 

Arg Ile Arg Val Thr Gly Leu Tyr Leu Gly Thr Asp Glu Lys Val Thr 
625                 630                 635                 640 

Leu Thr Tyr Asn Val Arg Leu Asn Asp Glu Phe Val Ser Asn Lys Phe 
                645                 650                 655     

Tyr Asp Thr Asn Gly Arg Thr Thr Leu His Pro Lys Glu Val Glu Gln 
            660                 665                 670         

Asn Thr Val Arg Asp Phe Pro Ile Pro Lys Ile Arg Asp Val Arg Lys 
        675                 680                 685             

Tyr Pro Glu Ile Thr Ile Ser Lys Glu Lys Lys Leu Gly Asp Ile Glu 
    690                 695                 700                 

Phe Ile Lys Val Asn Lys Asn Asp Lys Lys Pro Leu Arg Gly Ala Val 
705                 710                 715                 720 

Phe Ser Leu Gln Lys Gln His Pro Asp Tyr Pro Asp Ile Tyr Gly Ala 
                725                 730                 735     

Ile Asp Gln Asn Gly Thr Tyr Gln Asn Val Arg Thr Gly Glu Asp Gly 
            740                 745                 750         

Lys Leu Thr Phe Lys Asn Leu Ser Asp Gly Lys Tyr Arg Leu Phe Glu 
        755                 760                 765             

Asn Ser Glu Pro Ala Gly Tyr Lys Pro Val Gln Asn Lys Pro Ile Val 
    770                 775                 780                 

Ala Phe Gln Ile Val Asn Gly Glu Val Arg Asp Val Thr Ser Ile Val 
785                 790                 795                 800 

Pro Gln Asp Ile Pro Ala Gly Tyr Glu Phe Thr Asn Asp Lys His Tyr 
                805                 810                 815     

Ile Thr Asn Glu Pro Ile Pro Pro Lys Arg Glu Gly Ser Gly Ser Gly 
            820                 825                 830         

Gly Gly Gly Ala Glu Thr Thr Asp Asp Lys Ile Ala Ala Gln Asp Asn 
        835                 840                 845             

Lys Ile Ser Asn Leu Thr Ala Gln Gln Gln Glu Ala Gln Lys Gln Val 
    850                 855                 860                 

Asp Gln Ile Gln Glu Gln Val Ser Ala Ile Gln Ala Glu Gln Ser Asn 
865                 870                 875                 880 

Leu Gln Ala Glu Asn Asp Arg Leu Gln Ala Glu Ser Lys Lys Leu Glu 
                885                 890                 895     

Gly Glu Ile Thr Glu Leu Ser Lys Asn Ile Val Ser Arg Asn Gln Ser 
            900                 905                 910         

Leu Glu Lys Gln Ala Arg Ser Ala Gln Thr Asn Gly Ala Val Thr Ser 
        915                 920                 925             

Tyr Ile Asn Thr Ile Val Asn Ser Lys Ser Ile Thr Glu Ala Ile Ser 
    930                 935                 940                 

Arg Val Ala Ala Met Ser Glu Ile Val Ser Ala Asn Asn Lys Met Leu 
945                 950                 955                 960 

Glu Gln Gln Lys Ala Asp Lys Lys Ala Ile Ser Glu Lys Gln Val Ala 
                965                 970                 975     

Asn Asn Asp Ala Ile Asn Thr Val Ile Ala Asn Gln Gln Lys Leu Ala 
            980                 985                 990         

Asp Asp Ala Gln Ala Leu Thr Thr Lys Gln Ala Glu Leu Lys Ala Ala 
        995                 1000                1005            

Glu Leu Ser Leu Ala Ala Glu Lys Ala Thr Ala Glu Gly Glu Lys Ala 
    1010                1015                1020                

Ser Leu Leu Glu Gln Lys Ala Ala Ala Glu Ala Glu Ala Arg Ala Ala 
1025                1030                1035                1040

Ala Val Ala Glu Ala Ala Tyr Lys Glu Lys Arg Ala Ser Gln Gln Gln 
                1045                1050                1055    

Ser Val Leu Ala Ser Ala Asn Thr Asn Leu Thr Ala Gln Val Gln Ala 
            1060                1065                1070        

Val Ser Glu Ser Ala Ala Ala Pro Val Arg Ala Lys Val Arg Pro Thr 
        1075                1080                1085            

Tyr Ser Thr Asn Ala Ser Ser Tyr Pro Ile Gly Glu Cys Thr Trp Gly 
    1090                1095                1100                

Val Lys Thr Leu Ala Pro Trp Ala Gly Asp Tyr Trp Gly Asn Gly Ala 
1105                1110                1115                1120

Gln Trp Ala Thr Ser Ala Ala Ala Ala Gly Phe Arg Thr Gly Ser Thr 
                1125                1130                1135    

Pro Gln Val Gly Ala Ile Ala Cys Trp Asn Asp Gly Gly Tyr Gly His 
            1140                1145                1150        

Val Ala Val Val Thr Ala Val Glu Ser Thr Thr Arg Ile Gln Val Ser 
        1155                1160                1165            

Glu Ser Asn Tyr Ala Gly Asn Arg Thr Ile Gly Asn His Arg Gly Trp 
    1170                1175                1180                

Phe Asn Pro Thr Thr Thr Ser Glu Gly Phe Val Thr Tyr Ile Tyr Ala 
1185                1190                1195                1200

Asp Ala Ala Ala Leu Glu His His His His His His 
                1205                1210        

<210>   212
<211>   2999
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Hybrid polypeptide

<400>   212
Met Ala Ser Glu Thr Pro Glu Thr Ser Pro Ala Ile Gly Lys Val Val 
1               5                   10                  15      

Ile Lys Glu Thr Gly Glu Gly Gly Ala Leu Leu Gly Asp Ala Val Phe 
            20                  25                  30          

Glu Leu Lys Asn Asn Thr Asp Gly Thr Thr Val Ser Gln Arg Thr Glu 
        35                  40                  45              

Ala Gln Thr Gly Glu Ala Ile Phe Ser Asn Ile Lys Pro Gly Thr Tyr 
    50                  55                  60                  

Thr Leu Thr Glu Ala Gln Pro Pro Val Gly Tyr Lys Pro Ser Thr Lys 
65                  70                  75                  80  

Gln Trp Thr Val Glu Val Glu Lys Asn Gly Arg Thr Thr Val Gln Gly 
                85                  90                  95      

Glu Gln Val Glu Asn Arg Glu Glu Ala Leu Ser Asp Gln Tyr Pro Gln 
            100                 105                 110         

Thr Gly Thr Tyr Pro Asp Val Gln Thr Pro Tyr Gln Ile Ile Lys Val 
        115                 120                 125             

Asp Gly Ser Glu Lys Asn Gly Gln His Lys Ala Leu Asn Pro Asn Pro 
    130                 135                 140                 

Tyr Glu Arg Val Ile Pro Glu Gly Thr Leu Ser Lys Arg Ile Tyr Gln 
145                 150                 155                 160 

Val Asn Asn Leu Asp Asp Asn Gln Tyr Gly Ile Glu Leu Thr Val Ser 
                165                 170                 175     

Gly Lys Thr Val Tyr Glu Gln Lys Asp Lys Ser Val Pro Leu Asp Val 
            180                 185                 190         

Val Ile Leu Leu Asp Asn Ser Asn Ser Met Ser Asn Ile Arg Asn Lys 
        195                 200                 205             

Asn Ala Arg Arg Ala Glu Arg Ala Gly Glu Ala Thr Arg Ser Leu Ile 
    210                 215                 220                 

Asp Lys Ile Thr Ser Asp Ser Glu Asn Arg Val Ala Leu Val Thr Tyr 
225                 230                 235                 240 

Ala Ser Thr Ile Phe Asp Gly Thr Glu Phe Thr Val Glu Lys Gly Val 
                245                 250                 255     

Ala Asp Lys Asn Gly Lys Arg Leu Asn Asp Ser Leu Phe Trp Asn Tyr 
            260                 265                 270         

Asp Gln Thr Ser Phe Thr Thr Asn Thr Lys Asp Tyr Ser Tyr Leu Lys 
        275                 280                 285             

Leu Thr Asn Asp Lys Asn Asp Ile Val Glu Leu Lys Asn Lys Val Pro 
    290                 295                 300                 

Thr Glu Ala Glu Asp His Asp Gly Asn Arg Leu Met Tyr Gln Phe Gly 
305                 310                 315                 320 

Ala Thr Phe Thr Gln Lys Ala Leu Met Lys Ala Asp Glu Ile Leu Thr 
                325                 330                 335     

Gln Gln Ala Arg Gln Asn Ser Gln Lys Val Ile Phe His Ile Thr Asp 
            340                 345                 350         

Gly Val Pro Thr Met Ser Tyr Pro Ile Asn Phe Asn His Ala Thr Phe 
        355                 360                 365             

Ala Pro Ser Tyr Gln Asn Gln Leu Asn Ala Phe Phe Ser Lys Ser Pro 
    370                 375                 380                 

Asn Lys Asp Gly Ile Leu Leu Ser Asp Phe Ile Thr Gln Ala Thr Ser 
385                 390                 395                 400 

Gly Glu His Thr Ile Val Arg Gly Asp Gly Gln Ser Tyr Gln Met Phe 
                405                 410                 415     

Thr Asp Lys Thr Val Tyr Glu Lys Gly Ala Pro Ala Ala Phe Pro Val 
            420                 425                 430         

Lys Pro Glu Lys Tyr Ser Glu Met Lys Ala Ala Gly Tyr Ala Val Ile 
        435                 440                 445             

Gly Asp Pro Ile Asn Gly Gly Tyr Ile Trp Leu Asn Trp Arg Glu Ser 
    450                 455                 460                 

Ile Leu Ala Tyr Pro Phe Asn Ser Asn Thr Ala Lys Ile Thr Asn His 
465                 470                 475                 480 

Gly Asp Pro Thr Arg Trp Tyr Tyr Asn Gly Asn Ile Ala Pro Asp Gly 
                485                 490                 495     

Tyr Asp Val Phe Thr Val Gly Ile Gly Ile Asn Gly Asp Pro Gly Thr 
            500                 505                 510         

Asp Glu Ala Thr Ala Thr Ser Phe Met Gln Ser Ile Ser Ser Lys Pro 
        515                 520                 525             

Glu Asn Tyr Thr Asn Val Thr Asp Thr Thr Lys Ile Leu Glu Gln Leu 
    530                 535                 540                 

Asn Arg Tyr Phe His Thr Ile Val Thr Glu Lys Lys Ser Ile Glu Asn 
545                 550                 555                 560 

Gly Thr Ile Thr Asp Pro Met Gly Glu Leu Ile Asp Leu Gln Leu Gly 
                565                 570                 575     

Thr Asp Gly Arg Phe Asp Pro Ala Asp Tyr Thr Leu Thr Ala Asn Asp 
            580                 585                 590         

Gly Ser Arg Leu Glu Asn Gly Gln Ala Val Gly Gly Pro Gln Asn Asp 
        595                 600                 605             

Gly Gly Leu Leu Lys Asn Ala Lys Val Leu Tyr Asp Thr Thr Glu Lys 
    610                 615                 620                 

Arg Ile Arg Val Thr Gly Leu Tyr Leu Gly Thr Asp Glu Lys Val Thr 
625                 630                 635                 640 

Leu Thr Tyr Asn Val Arg Leu Asn Asp Glu Phe Val Ser Asn Lys Phe 
                645                 650                 655     

Tyr Asp Thr Asn Gly Arg Thr Thr Leu His Pro Lys Glu Val Glu Gln 
            660                 665                 670         

Asn Thr Val Arg Asp Phe Pro Ile Pro Lys Ile Arg Asp Val Arg Lys 
        675                 680                 685             

Tyr Pro Glu Ile Thr Ile Ser Lys Glu Lys Lys Leu Gly Asp Ile Glu 
    690                 695                 700                 

Phe Ile Lys Val Asn Lys Asn Asp Lys Lys Pro Leu Arg Gly Ala Val 
705                 710                 715                 720 

Phe Ser Leu Gln Lys Gln His Pro Asp Tyr Pro Asp Ile Tyr Gly Ala 
                725                 730                 735     

Ile Asp Gln Asn Gly Thr Tyr Gln Asn Val Arg Thr Gly Glu Asp Gly 
            740                 745                 750         

Lys Leu Thr Phe Lys Asn Leu Ser Asp Gly Lys Tyr Arg Leu Phe Glu 
        755                 760                 765             

Asn Ser Glu Pro Ala Gly Tyr Lys Pro Val Gln Asn Lys Pro Ile Val 
    770                 775                 780                 

Ala Phe Gln Ile Val Asn Gly Glu Val Arg Asp Val Thr Ser Ile Val 
785                 790                 795                 800 

Pro Gln Asp Ile Pro Ala Gly Tyr Glu Phe Thr Asn Asp Lys His Tyr 
                805                 810                 815     

Ile Thr Asn Glu Pro Ile Pro Pro Lys Arg Glu Gly Ser Gly Ser Gly 
            820                 825                 830         

Gly Gly Gly Asp Glu Thr Leu Ile Thr His Thr Ala Glu Lys Pro Lys 
        835                 840                 845             

Glu Glu Lys Met Ile Val Glu Glu Lys Ala Asp Lys Ala Leu Glu Thr 
    850                 855                 860                 

Lys Asn Ile Val Glu Arg Thr Glu Gln Ser Glu Pro Ser Ser Thr Glu 
865                 870                 875                 880 

Ala Ile Ala Ser Glu Lys Lys Glu Asp Glu Ala Val Thr Pro Lys Glu 
                885                 890                 895     

Glu Lys Val Ser Ala Lys Pro Glu Glu Lys Ala Pro Arg Ile Glu Ser 
            900                 905                 910         

Gln Ala Ser Asn Gln Glu Lys Pro Leu Lys Glu Asp Ala Lys Ala Val 
        915                 920                 925             

Thr Asn Glu Glu Val Asn Gln Met Ile Glu Asp Arg Lys Val Asp Phe 
    930                 935                 940                 

Asn Gln Asn Trp Tyr Phe Lys Leu Asn Ala Asn Ser Lys Glu Ala Ile 
945                 950                 955                 960 

Lys Pro Asp Ala Asp Val Ser Thr Trp Lys Lys Leu Asp Leu Pro Tyr 
                965                 970                 975     

Asp Trp Ser Ile Phe Asn Asp Phe Asp His Glu Ser Pro Ala Gln Asn 
            980                 985                 990         

Glu Gly Gly Gln Leu Asn Gly Gly Glu Ala Trp Tyr Arg Lys Thr Phe 
        995                 1000                1005            

Lys Leu Asp Glu Lys Asp Leu Lys Lys Asn Val Arg Leu Thr Phe Asp 
    1010                1015                1020                

Gly Val Tyr Met Asp Ser Gln Val Tyr Val Asn Gly Gln Leu Val Gly 
1025                1030                1035                1040

His Tyr Pro Asn Gly Tyr Asn Gln Phe Ser Tyr Asp Ile Thr Lys Tyr 
                1045                1050                1055    

Leu Gln Lys Asp Gly Arg Glu Asn Val Ile Ala Val His Ala Val Asn 
            1060                1065                1070        

Lys Gln Pro Ser Ser Arg Trp Tyr Ser Gly Ser Gly Ile Tyr Arg Asp 
        1075                1080                1085            

Val Thr Leu Gln Val Thr Asp Lys Val His Val Glu Lys Asn Gly Thr 
    1090                1095                1100                

Thr Ile Leu Thr Pro Lys Leu Glu Glu Gln Gln His Gly Lys Val Glu 
1105                1110                1115                1120

Thr His Val Thr Ser Lys Ile Val Asn Thr Asp Asp Lys Asp His Glu 
                1125                1130                1135    

Leu Val Ala Glu Tyr Gln Ile Val Glu Arg Gly Gly His Ala Val Thr 
            1140                1145                1150        

Gly Leu Val Arg Thr Ala Ser Arg Thr Leu Lys Ala His Glu Ser Thr 
        1155                1160                1165            

Ser Leu Asp Ala Ile Leu Glu Val Glu Arg Pro Lys Leu Trp Thr Val 
    1170                1175                1180                

Leu Asn Asp Lys Pro Ala Leu Tyr Glu Leu Ile Thr Arg Val Tyr Arg 
1185                1190                1195                1200

Asp Gly Gln Leu Val Asp Ala Lys Lys Asp Leu Phe Gly Tyr Arg Tyr 
                1205                1210                1215    

Tyr His Trp Thr Pro Asn Glu Gly Phe Ser Leu Asn Gly Glu Arg Ile 
            1220                1225                1230        

Lys Phe His Gly Val Ser Leu His His Asp His Gly Ala Leu Gly Ala 
        1235                1240                1245            

Glu Glu Asn Tyr Lys Ala Glu Tyr Arg Arg Leu Lys Gln Met Lys Glu 
    1250                1255                1260                

Met Gly Val Asn Ser Ile Arg Thr Thr His Asn Pro Ala Ser Glu Gln 
1265                1270                1275                1280

Thr Leu Gln Ile Ala Ala Glu Leu Gly Leu Leu Val Gln Glu Glu Ala 
                1285                1290                1295    

Phe Asp Thr Trp Tyr Gly Gly Lys Lys Pro Tyr Asp Tyr Gly Arg Phe 
            1300                1305                1310        

Phe Glu Lys Asp Ala Thr His Pro Glu Ala Arg Lys Gly Glu Lys Trp 
        1315                1320                1325            

Ser Asp Phe Asp Leu Arg Thr Met Val Glu Arg Gly Lys Asn Asn Pro 
    1330                1335                1340                

Ala Ile Phe Met Trp Ser Ile Gly Asn Glu Ile Gly Glu Ala Asn Gly 
1345                1350                1355                1360

Asp Ala His Ser Leu Ala Thr Val Lys Arg Leu Val Lys Val Ile Lys 
                1365                1370                1375    

Asp Val Asp Lys Thr Arg Tyr Val Thr Met Gly Ala Asp Lys Phe Arg 
            1380                1385                1390        

Phe Gly Asn Gly Ser Gly Gly His Glu Lys Ile Ala Asp Glu Leu Asp 
        1395                1400                1405            

Ala Val Gly Phe Asn Tyr Ser Glu Asp Asn Tyr Lys Ala Leu Arg Ala 
    1410                1415                1420                

Lys His Pro Lys Trp Leu Ile Tyr Gly Ser Glu Thr Ser Ser Ala Thr 
1425                1430                1435                1440

Arg Thr Arg Gly Ser Tyr Tyr Arg Pro Glu Arg Glu Leu Lys His Ser 
                1445                1450                1455    

Asn Gly Pro Glu Arg Asn Tyr Glu Gln Ser Asp Tyr Gly Asn Asp Arg 
            1460                1465                1470        

Val Gly Trp Gly Lys Thr Ala Thr Ala Ser Trp Thr Phe Asp Arg Asp 
        1475                1480                1485            

Asn Ala Gly Tyr Ala Gly Gln Phe Ile Trp Thr Gly Thr Asp Tyr Ile 
    1490                1495                1500                

Gly Glu Pro Thr Pro Trp His Asn Gln Asn Gln Thr Pro Val Lys Ser 
1505                1510                1515                1520

Ser Tyr Phe Gly Ile Val Asp Thr Ala Gly Ile Pro Lys His Asp Phe 
                1525                1530                1535    

Tyr Leu Tyr Gln Ser Gln Trp Val Ser Val Lys Lys Lys Pro Met Val 
            1540                1545                1550        

His Leu Leu Pro His Trp Asn Trp Glu Asn Lys Glu Leu Ala Ser Lys 
        1555                1560                1565            

Val Ala Asp Ser Glu Gly Lys Ile Pro Val Arg Ala Tyr Ser Asn Ala 
    1570                1575                1580                

Ser Ser Val Glu Leu Phe Leu Asn Gly Lys Ser Leu Gly Leu Lys Thr 
1585                1590                1595                1600

Phe Asn Lys Lys Gln Thr Ser Asp Gly Arg Thr Tyr Gln Glu Gly Ala 
                1605                1610                1615    

Asn Ala Asn Glu Leu Tyr Leu Glu Trp Lys Val Ala Tyr Gln Pro Gly 
            1620                1625                1630        

Thr Leu Glu Ala Ile Ala Arg Asp Glu Ser Gly Lys Glu Ile Ala Arg 
        1635                1640                1645            

Asp Lys Ile Thr Thr Ala Gly Lys Pro Ala Ala Val Arg Leu Ile Lys 
    1650                1655                1660                

Glu Asp His Ala Ile Ala Ala Asp Gly Lys Asp Leu Thr Tyr Ile Tyr 
1665                1670                1675                1680

Tyr Glu Ile Val Asp Ser Gln Gly Asn Val Val Pro Thr Ala Asn Asn 
                1685                1690                1695    

Leu Val Arg Phe Gln Leu His Gly Gln Gly Gln Leu Val Gly Val Asp 
            1700                1705                1710        

Asn Gly Glu Gln Ala Ser Arg Glu Arg Tyr Lys Ala Gln Ala Asp Gly 
        1715                1720                1725            

Ser Trp Ile Arg Lys Ala Phe Asn Gly Lys Gly Val Ala Ile Val Lys 
    1730                1735                1740                

Ser Thr Glu Gln Ala Gly Lys Phe Thr Leu Thr Ala His Ser Asp Leu 
1745                1750                1755                1760

Leu Lys Ser Asn Gln Val Thr Val Phe Thr Gly Lys Lys Glu Gly Gln 
                1765                1770                1775    

Glu Lys Thr Val Leu Gly Thr Glu Val Pro Lys Val Gln Thr Ile Ile 
            1780                1785                1790        

Gly Glu Ala Pro Glu Met Pro Thr Thr Val Pro Phe Val Tyr Ser Asp 
        1795                1800                1805            

Gly Ser Arg Ala Glu Arg Pro Val Thr Trp Ser Ser Val Asp Val Ser 
    1810                1815                1820                

Lys Pro Gly Ile Val Thr Val Lys Gly Met Ala Asp Gly Arg Glu Val 
1825                1830                1835                1840

Glu Ala Arg Val Glu Val Ile Ala Leu Lys Ser Glu Leu Pro Val Val 
                1845                1850                1855    

Lys Arg Ile Ala Pro Asn Thr Asp Leu Asn Ser Val Asp Lys Ser Val 
            1860                1865                1870        

Ser Tyr Val Leu Ile Asp Gly Ser Val Glu Glu Tyr Glu Val Asp Lys 
        1875                1880                1885            

Trp Glu Ile Ala Glu Glu Asp Lys Ala Lys Leu Ala Ile Pro Gly Ser 
    1890                1895                1900                

Arg Ile Gln Ala Thr Gly Tyr Leu Glu Gly Gln Pro Ile His Ala Thr 
1905                1910                1915                1920

Leu Val Val Glu Glu Gly Asn Pro Ala Ala Pro Ala Val Pro Thr Val 
                1925                1930                1935    

Thr Val Gly Gly Glu Ala Val Thr Gly Leu Thr Ser Gln Lys Pro Met 
            1940                1945                1950        

Gln Tyr Arg Thr Leu Ala Tyr Gly Ala Lys Leu Pro Glu Val Thr Ala 
        1955                1960                1965            

Ser Ala Lys Asn Ala Ala Val Thr Val Leu Gln Ala Ser Ala Ala Asn 
    1970                1975                1980                

Gly Met Arg Ala Ser Ile Phe Ile Gln Pro Lys Asp Gly Gly Pro Leu 
1985                1990                1995                2000

Gln Thr Tyr Ala Ile Gln Phe Leu Glu Glu Ala Pro Lys Ile Ala His 
                2005                2010                2015    

Leu Ser Leu Gln Val Glu Lys Ala Asp Ser Leu Lys Glu Asp Gln Thr 
            2020                2025                2030        

Val Lys Leu Ser Val Arg Ala His Tyr Gln Asp Gly Thr Gln Ala Val 
        2035                2040                2045            

Leu Pro Ala Asp Lys Val Thr Phe Ser Thr Ser Gly Glu Gly Glu Val 
    2050                2055                2060                

Ala Ile Arg Lys Gly Met Leu Glu Leu His Lys Pro Gly Ala Val Thr 
2065                2070                2075                2080

Leu Asn Ala Glu Tyr Glu Gly Ala Lys Asp Gln Val Glu Leu Thr Ile 
                2085                2090                2095    

Gln Ala Asn Thr Glu Lys Lys Ile Ala Gln Ser Ile Arg Pro Val Asn 
            2100                2105                2110        

Val Val Thr Asp Leu His Gln Glu Pro Ser Leu Pro Ala Thr Val Thr 
        2115                2120                2125            

Val Glu Tyr Asp Lys Gly Phe Pro Lys Thr His Lys Val Thr Trp Gln 
    2130                2135                2140                

Ala Ile Pro Lys Glu Lys Leu Asp Ser Tyr Gln Thr Phe Glu Val Leu 
2145                2150                2155                2160

Gly Lys Val Glu Gly Ile Asp Leu Glu Ala Arg Ala Lys Val Ser Val 
                2165                2170                2175    

Glu Gly Ile Val Ser Val Glu Glu Val Ser Val Thr Thr Pro Ile Ala 
            2180                2185                2190        

Glu Ala Pro Gln Leu Pro Glu Ser Val Arg Thr Tyr Asp Ser Asn Gly 
        2195                2200                2205            

His Val Ser Ser Ala Lys Val Ala Trp Asp Ala Ile Arg Pro Glu Gln 
    2210                2215                2220                

Tyr Ala Lys Glu Gly Val Phe Thr Val Asn Gly Arg Leu Glu Gly Thr 
2225                2230                2235                2240

Gln Leu Thr Thr Lys Leu His Val Arg Val Ser Ala Gln Thr Glu Gln 
                2245                2250                2255    

Gly Ala Asn Ile Ser Asp Gln Trp Thr Gly Ser Glu Leu Pro Leu Ala 
            2260                2265                2270        

Phe Ala Ser Asp Ser Asn Pro Ser Asp Pro Val Ser Asn Val Asn Asp 
        2275                2280                2285            

Lys Leu Ile Ser Tyr Asn Asn Gln Pro Ala Asn Arg Trp Thr Asn Trp 
    2290                2295                2300                

Asn Arg Thr Asn Pro Glu Ala Ser Val Gly Val Leu Phe Gly Asp Ser 
2305                2310                2315                2320

Gly Ile Leu Ser Lys Arg Ser Val Asp Asn Leu Ser Val Gly Phe His 
                2325                2330                2335    

Glu Asp His Gly Val Gly Val Pro Lys Ser Tyr Val Ile Glu Tyr Tyr 
            2340                2345                2350        

Val Gly Lys Thr Val Pro Thr Ala Pro Lys Asn Pro Ser Phe Val Gly 
        2355                2360                2365            

Asn Glu Asp His Val Phe Asn Asp Ser Ala Asn Trp Lys Pro Val Thr 
    2370                2375                2380                

Asn Leu Lys Ala Pro Ala Gln Leu Lys Ala Gly Glu Met Asn His Phe 
2385                2390                2395                2400

Ser Phe Asp Lys Val Glu Thr Tyr Ala Val Arg Ile Arg Met Val Lys 
                2405                2410                2415    

Ala Asp Asn Lys Arg Gly Thr Ser Ile Thr Glu Val Gln Ile Phe Ala 
            2420                2425                2430        

Lys Gln Val Ala Ala Ala Lys Gln Gly Gln Thr Arg Ile Gln Val Asp 
        2435                2440                2445            

Gly Lys Asp Leu Ala Asn Phe Asn Pro Asp Leu Thr Asp Tyr Tyr Leu 
    2450                2455                2460                

Glu Ser Val Asp Gly Lys Val Pro Ala Val Thr Ala Ser Val Ser Asn 
2465                2470                2475                2480

Asn Gly Leu Ala Thr Val Val Pro Ser Val Arg Glu Gly Glu Pro Val 
                2485                2490                2495    

Arg Val Ile Ala Lys Ala Glu Asn Gly Asp Ile Leu Gly Glu Tyr Arg 
            2500                2505                2510        

Leu His Phe Thr Lys Asp Lys Ser Leu Leu Ser His Lys Pro Val Ala 
        2515                2520                2525            

Ala Val Lys Gln Ala Arg Leu Leu Gln Val Gly Gln Ala Leu Glu Leu 
    2530                2535                2540                

Pro Thr Lys Val Pro Val Tyr Phe Thr Gly Lys Asp Gly Tyr Glu Thr 
2545                2550                2555                2560

Lys Asp Leu Thr Val Glu Trp Glu Glu Val Pro Ala Glu Asn Leu Thr 
                2565                2570                2575    

Lys Ala Gly Gln Phe Thr Val Arg Gly Arg Val Leu Gly Ser Asn Leu 
            2580                2585                2590        

Val Ala Glu Ile Thr Val Arg Val Thr Asp Lys Leu Gly Glu Thr Leu 
        2595                2600                2605            

Ser Asp Asn Pro Asn Tyr Asp Glu Asn Ser Asn Gln Ala Phe Ala Ser 
    2610                2615                2620                

Ala Thr Asn Asp Ile Asp Lys Asn Ser His Asp Arg Val Asp Tyr Leu 
2625                2630                2635                2640

Asn Asp Gly Asp His Ser Glu Asn Arg Arg Trp Thr Asn Trp Ser Pro 
                2645                2650                2655    

Thr Pro Ser Ser Asn Pro Glu Val Ser Ala Gly Val Ile Phe Arg Glu 
            2660                2665                2670        

Asn Gly Lys Ile Val Glu Arg Thr Val Thr Gln Gly Lys Val Gln Phe 
        2675                2680                2685            

Phe Ala Asp Ser Gly Thr Asp Ala Pro Ser Lys Leu Val Leu Glu Arg 
    2690                2695                2700                

Tyr Val Gly Pro Glu Phe Glu Val Pro Thr Tyr Tyr Ser Asn Tyr Gln 
2705                2710                2715                2720

Ala Tyr Asp Ala Asp His Pro Phe Asn Asn Pro Glu Asn Trp Glu Ala 
                2725                2730                2735    

Val Pro Tyr Arg Ala Asp Lys Asp Ile Ala Ala Gly Asp Glu Ile Asn 
            2740                2745                2750        

Val Thr Phe Lys Ala Ile Lys Ala Lys Ala Met Arg Trp Arg Met Glu 
        2755                2760                2765            

Arg Lys Ala Asp Lys Ser Gly Val Ala Met Ile Glu Met Thr Phe Leu 
    2770                2775                2780                

Ala Pro Ser Glu Leu Pro Gln Glu Ser Thr Gln Ser Lys Ile Leu Val 
2785                2790                2795                2800

Asp Gly Lys Glu Leu Ala Asp Phe Ala Glu Asn Arg Gln Asp Tyr Gln 
                2805                2810                2815    

Ile Thr Tyr Lys Gly Gln Arg Pro Lys Val Ser Val Glu Glu Asn Asn 
            2820                2825                2830        

Gln Val Ala Ser Thr Val Val Asp Ser Gly Glu Asp Ser Phe Pro Val 
        2835                2840                2845            

Leu Val Arg Leu Val Ser Glu Ser Gly Lys Gln Val Lys Glu Tyr Arg 
    2850                2855                2860                

Ile His Leu Thr Lys Glu Lys Pro Val Ser Glu Lys Thr Val Ala Ala 
2865                2870                2875                2880

Val Gln Glu Asp Leu Pro Lys Ile Glu Phe Val Glu Lys Asp Leu Ala 
                2885                2890                2895    

Tyr Lys Thr Val Glu Lys Lys Asp Ser Thr Leu Tyr Leu Gly Glu Thr 
            2900                2905                2910        

Arg Val Glu Gln Glu Gly Lys Val Gly Lys Glu Arg Ile Phe Thr Ala 
        2915                2920                2925            

Ile Asn Pro Asp Gly Ser Lys Glu Glu Lys Leu Arg Glu Val Val Glu 
    2930                2935                2940                

Val Pro Thr Asp Arg Ile Val Leu Val Gly Thr Lys Pro Val Ala Gln 
2945                2950                2955                2960

Glu Ala Lys Lys Pro Gln Val Ser Glu Lys Ala Asp Thr Lys Pro Ile 
                2965                2970                2975    

Asp Ser Ser Glu Ala Ser Gln Thr Asn Lys Ala Gln Ala Ala Ala Leu 
            2980                2985                2990        

Glu His His His His His His 
        2995                

<210>   213
<211>   1909
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Hybrid polypeptide

<400>   213
Met Ala Ser Glu Thr Pro Glu Thr Ser Pro Ala Ile Gly Lys Val Val 
1               5                   10                  15      

Ile Lys Glu Thr Gly Glu Gly Gly Ala Leu Leu Gly Asp Ala Val Phe 
            20                  25                  30          

Glu Leu Lys Asn Asn Thr Asp Gly Thr Thr Val Ser Gln Arg Thr Glu 
        35                  40                  45              

Ala Gln Thr Gly Glu Ala Ile Phe Ser Asn Ile Lys Pro Gly Thr Tyr 
    50                  55                  60                  

Thr Leu Thr Glu Ala Gln Pro Pro Val Gly Tyr Lys Pro Ser Thr Lys 
65                  70                  75                  80  

Gln Trp Thr Val Glu Val Glu Lys Asn Gly Arg Thr Thr Val Gln Gly 
                85                  90                  95      

Glu Gln Val Glu Asn Arg Glu Glu Ala Leu Ser Asp Gln Tyr Pro Gln 
            100                 105                 110         

Thr Gly Thr Tyr Pro Asp Val Gln Thr Pro Tyr Gln Ile Ile Lys Val 
        115                 120                 125             

Asp Gly Ser Glu Lys Asn Gly Gln His Lys Ala Leu Asn Pro Asn Pro 
    130                 135                 140                 

Tyr Glu Arg Val Ile Pro Glu Gly Thr Leu Ser Lys Arg Ile Tyr Gln 
145                 150                 155                 160 

Val Asn Asn Leu Asp Asp Asn Gln Tyr Gly Ile Glu Leu Thr Val Ser 
                165                 170                 175     

Gly Lys Thr Val Tyr Glu Gln Lys Asp Lys Ser Val Pro Leu Asp Val 
            180                 185                 190         

Val Ile Leu Leu Asp Asn Ser Asn Ser Met Ser Asn Ile Arg Asn Lys 
        195                 200                 205             

Asn Ala Arg Arg Ala Glu Arg Ala Gly Glu Ala Thr Arg Ser Leu Ile 
    210                 215                 220                 

Asp Lys Ile Thr Ser Asp Ser Glu Asn Arg Val Ala Leu Val Thr Tyr 
225                 230                 235                 240 

Ala Ser Thr Ile Phe Asp Gly Thr Glu Phe Thr Val Glu Lys Gly Val 
                245                 250                 255     

Ala Asp Lys Asn Gly Lys Arg Leu Asn Asp Ser Leu Phe Trp Asn Tyr 
            260                 265                 270         

Asp Gln Thr Ser Phe Thr Thr Asn Thr Lys Asp Tyr Ser Tyr Leu Lys 
        275                 280                 285             

Leu Thr Asn Asp Lys Asn Asp Ile Val Glu Leu Lys Asn Lys Val Pro 
    290                 295                 300                 

Thr Glu Ala Glu Asp His Asp Gly Asn Arg Leu Met Tyr Gln Phe Gly 
305                 310                 315                 320 

Ala Thr Phe Thr Gln Lys Ala Leu Met Lys Ala Asp Glu Ile Leu Thr 
                325                 330                 335     

Gln Gln Ala Arg Gln Asn Ser Gln Lys Val Ile Phe His Ile Thr Asp 
            340                 345                 350         

Gly Val Pro Thr Met Ser Tyr Pro Ile Asn Phe Asn His Ala Thr Phe 
        355                 360                 365             

Ala Pro Ser Tyr Gln Asn Gln Leu Asn Ala Phe Phe Ser Lys Ser Pro 
    370                 375                 380                 

Asn Lys Asp Gly Ile Leu Leu Ser Asp Phe Ile Thr Gln Ala Thr Ser 
385                 390                 395                 400 

Gly Glu His Thr Ile Val Arg Gly Asp Gly Gln Ser Tyr Gln Met Phe 
                405                 410                 415     

Thr Asp Lys Thr Val Tyr Glu Lys Gly Ala Pro Ala Ala Phe Pro Val 
            420                 425                 430         

Lys Pro Glu Lys Tyr Ser Glu Met Lys Ala Ala Gly Tyr Ala Val Ile 
        435                 440                 445             

Gly Asp Pro Ile Asn Gly Gly Tyr Ile Trp Leu Asn Trp Arg Glu Ser 
    450                 455                 460                 

Ile Leu Ala Tyr Pro Phe Asn Ser Asn Thr Ala Lys Ile Thr Asn His 
465                 470                 475                 480 

Gly Asp Pro Thr Arg Trp Tyr Tyr Asn Gly Asn Ile Ala Pro Asp Gly 
                485                 490                 495     

Tyr Asp Val Phe Thr Val Gly Ile Gly Ile Asn Gly Asp Pro Gly Thr 
            500                 505                 510         

Asp Glu Ala Thr Ala Thr Ser Phe Met Gln Ser Ile Ser Ser Lys Pro 
        515                 520                 525             

Glu Asn Tyr Thr Asn Val Thr Asp Thr Thr Lys Ile Leu Glu Gln Leu 
    530                 535                 540                 

Asn Arg Tyr Phe His Thr Ile Val Thr Glu Lys Lys Ser Ile Glu Asn 
545                 550                 555                 560 

Gly Thr Ile Thr Asp Pro Met Gly Glu Leu Ile Asp Leu Gln Leu Gly 
                565                 570                 575     

Thr Asp Gly Arg Phe Asp Pro Ala Asp Tyr Thr Leu Thr Ala Asn Asp 
            580                 585                 590         

Gly Ser Arg Leu Glu Asn Gly Gln Ala Val Gly Gly Pro Gln Asn Asp 
        595                 600                 605             

Gly Gly Leu Leu Lys Asn Ala Lys Val Leu Tyr Asp Thr Thr Glu Lys 
    610                 615                 620                 

Arg Ile Arg Val Thr Gly Leu Tyr Leu Gly Thr Asp Glu Lys Val Thr 
625                 630                 635                 640 

Leu Thr Tyr Asn Val Arg Leu Asn Asp Glu Phe Val Ser Asn Lys Phe 
                645                 650                 655     

Tyr Asp Thr Asn Gly Arg Thr Thr Leu His Pro Lys Glu Val Glu Gln 
            660                 665                 670         

Asn Thr Val Arg Asp Phe Pro Ile Pro Lys Ile Arg Asp Val Arg Lys 
        675                 680                 685             

Tyr Pro Glu Ile Thr Ile Ser Lys Glu Lys Lys Leu Gly Asp Ile Glu 
    690                 695                 700                 

Phe Ile Lys Val Asn Lys Asn Asp Lys Lys Pro Leu Arg Gly Ala Val 
705                 710                 715                 720 

Phe Ser Leu Gln Lys Gln His Pro Asp Tyr Pro Asp Ile Tyr Gly Ala 
                725                 730                 735     

Ile Asp Gln Asn Gly Thr Tyr Gln Asn Val Arg Thr Gly Glu Asp Gly 
            740                 745                 750         

Lys Leu Thr Phe Lys Asn Leu Ser Asp Gly Lys Tyr Arg Leu Phe Glu 
        755                 760                 765             

Asn Ser Glu Pro Ala Gly Tyr Lys Pro Val Gln Asn Lys Pro Ile Val 
    770                 775                 780                 

Ala Phe Gln Ile Val Asn Gly Glu Val Arg Asp Val Thr Ser Ile Val 
785                 790                 795                 800 

Pro Gln Asp Ile Pro Ala Gly Tyr Glu Phe Thr Asn Asp Lys His Tyr 
                805                 810                 815     

Ile Thr Asn Glu Pro Ile Pro Pro Lys Arg Glu Gly Ser Gly Ser Gly 
            820                 825                 830         

Gly Gly Gly Asp Glu Thr Leu Ile Thr His Thr Ala Glu Lys Pro Lys 
        835                 840                 845             

Glu Glu Lys Met Ile Val Glu Glu Lys Ala Asp Lys Ala Leu Glu Thr 
    850                 855                 860                 

Lys Asn Ile Val Glu Arg Thr Glu Gln Ser Glu Pro Ser Ser Thr Glu 
865                 870                 875                 880 

Ala Ile Ala Ser Glu Lys Lys Glu Asp Glu Ala Val Thr Pro Lys Glu 
                885                 890                 895     

Glu Lys Val Ser Ala Lys Pro Glu Glu Lys Ala Pro Arg Ile Glu Ser 
            900                 905                 910         

Gln Ala Ser Asn Gln Glu Lys Pro Leu Lys Glu Asp Ala Lys Ala Val 
        915                 920                 925             

Thr Asn Glu Glu Val Asn Gln Met Ile Glu Asp Arg Lys Val Asp Phe 
    930                 935                 940                 

Asn Gln Asn Trp Tyr Phe Lys Leu Asn Ala Asn Ser Lys Glu Ala Ile 
945                 950                 955                 960 

Lys Pro Asp Ala Asp Val Ser Thr Trp Lys Lys Leu Asp Leu Pro Tyr 
                965                 970                 975     

Asp Trp Ser Ile Phe Asn Asp Phe Asp His Glu Ser Pro Ala Gln Asn 
            980                 985                 990         

Glu Gly Gly Gln Leu Asn Gly Gly Glu Ala Trp Tyr Arg Lys Thr Phe 
        995                 1000                1005            

Lys Leu Asp Glu Lys Asp Leu Lys Lys Asn Val Arg Leu Thr Phe Asp 
    1010                1015                1020                

Gly Val Tyr Met Asp Ser Gln Val Tyr Val Asn Gly Gln Leu Val Gly 
1025                1030                1035                1040

His Tyr Pro Asn Gly Tyr Asn Gln Phe Ser Tyr Asp Ile Thr Lys Tyr 
                1045                1050                1055    

Leu Gln Lys Asp Gly Arg Glu Asn Val Ile Ala Val His Ala Val Asn 
            1060                1065                1070        

Lys Gln Pro Ser Ser Arg Trp Tyr Ser Gly Ser Gly Ile Tyr Arg Asp 
        1075                1080                1085            

Val Thr Leu Gln Val Thr Asp Lys Val His Val Glu Lys Asn Gly Thr 
    1090                1095                1100                

Thr Ile Leu Thr Pro Lys Leu Glu Glu Gln Gln His Gly Lys Val Glu 
1105                1110                1115                1120

Thr His Val Thr Ser Lys Ile Val Asn Thr Asp Asp Lys Asp His Glu 
                1125                1130                1135    

Leu Val Ala Glu Tyr Gln Ile Val Glu Arg Gly Gly His Ala Val Thr 
            1140                1145                1150        

Gly Leu Val Arg Thr Ala Ser Arg Thr Leu Lys Ala His Glu Ser Thr 
        1155                1160                1165            

Ser Leu Asp Ala Ile Leu Glu Val Glu Arg Pro Lys Leu Trp Thr Val 
    1170                1175                1180                

Leu Asn Asp Lys Pro Ala Leu Tyr Glu Leu Ile Thr Arg Val Tyr Arg 
1185                1190                1195                1200

Asp Gly Gln Leu Val Asp Ala Lys Lys Asp Leu Phe Gly Tyr Arg Tyr 
                1205                1210                1215    

Tyr His Trp Thr Pro Asn Glu Gly Phe Ser Leu Asn Gly Glu Arg Ile 
            1220                1225                1230        

Lys Phe His Gly Val Ser Leu His His Asp His Gly Ala Leu Gly Ala 
        1235                1240                1245            

Glu Glu Asn Tyr Lys Ala Glu Tyr Arg Arg Leu Lys Gln Met Lys Glu 
    1250                1255                1260                

Met Gly Val Asn Ser Ile Arg Thr Thr His Asn Pro Ala Ser Glu Gln 
1265                1270                1275                1280

Thr Leu Gln Ile Ala Ala Glu Leu Gly Leu Leu Val Gln Glu Glu Ala 
                1285                1290                1295    

Phe Asp Thr Trp Tyr Gly Gly Lys Lys Pro Tyr Asp Tyr Gly Arg Phe 
            1300                1305                1310        

Phe Glu Lys Asp Ala Thr His Pro Glu Ala Arg Lys Gly Glu Lys Trp 
        1315                1320                1325            

Ser Asp Phe Asp Leu Arg Thr Met Val Glu Arg Gly Lys Asn Asn Pro 
    1330                1335                1340                

Ala Ile Phe Met Trp Ser Ile Gly Asn Glu Ile Gly Glu Ala Asn Gly 
1345                1350                1355                1360

Asp Ala His Ser Leu Ala Thr Val Lys Arg Leu Val Lys Val Ile Lys 
                1365                1370                1375    

Asp Val Asp Lys Thr Arg Tyr Val Thr Met Gly Ala Asp Lys Phe Arg 
            1380                1385                1390        

Phe Gly Asn Gly Ser Gly Gly His Glu Lys Ile Ala Asp Glu Leu Asp 
        1395                1400                1405            

Ala Val Gly Phe Asn Tyr Ser Glu Asp Asn Tyr Lys Ala Leu Arg Ala 
    1410                1415                1420                

Lys His Pro Lys Trp Leu Ile Tyr Gly Ser Glu Thr Ser Ser Ala Thr 
1425                1430                1435                1440

Arg Thr Arg Gly Ser Tyr Tyr Arg Pro Glu Arg Glu Leu Lys His Ser 
                1445                1450                1455    

Asn Gly Pro Glu Arg Asn Tyr Glu Gln Ser Asp Tyr Gly Asn Asp Arg 
            1460                1465                1470        

Val Gly Trp Gly Lys Thr Ala Thr Ala Ser Trp Thr Phe Asp Arg Asp 
        1475                1480                1485            

Asn Ala Gly Tyr Ala Gly Gln Phe Ile Trp Thr Gly Thr Asp Tyr Ile 
    1490                1495                1500                

Gly Glu Pro Thr Pro Trp His Asn Gln Asn Gln Thr Pro Val Lys Ser 
1505                1510                1515                1520

Ser Tyr Phe Gly Ile Val Asp Thr Ala Gly Ile Pro Lys His Asp Phe 
                1525                1530                1535    

Tyr Leu Tyr Gln Ser Gln Trp Val Ser Val Lys Lys Lys Pro Met Val 
            1540                1545                1550        

His Leu Leu Pro His Trp Asn Trp Glu Asn Lys Glu Leu Ala Ser Lys 
        1555                1560                1565            

Val Ala Asp Ser Glu Gly Lys Ile Pro Val Arg Ala Tyr Ser Asn Ala 
    1570                1575                1580                

Ser Ser Val Glu Leu Phe Leu Asn Gly Lys Ser Leu Gly Leu Lys Thr 
1585                1590                1595                1600

Phe Asn Lys Lys Gln Thr Ser Asp Gly Arg Thr Tyr Gln Glu Gly Ala 
                1605                1610                1615    

Asn Ala Asn Glu Leu Tyr Leu Glu Trp Lys Val Ala Tyr Gln Pro Gly 
            1620                1625                1630        

Thr Leu Glu Ala Ile Ala Arg Asp Glu Ser Gly Lys Glu Ile Ala Arg 
        1635                1640                1645            

Asp Lys Ile Thr Thr Ala Gly Lys Pro Ala Ala Val Arg Leu Ile Lys 
    1650                1655                1660                

Glu Asp His Ala Ile Ala Ala Asp Gly Lys Asp Leu Thr Tyr Ile Tyr 
1665                1670                1675                1680

Tyr Glu Ile Val Asp Ser Gln Gly Asn Val Val Pro Thr Ala Asn Asn 
                1685                1690                1695    

Leu Val Arg Phe Gln Leu His Gly Gln Gly Gln Leu Val Gly Val Asp 
            1700                1705                1710        

Asn Gly Glu Gln Ala Ser Arg Glu Arg Tyr Lys Ala Gln Ala Asp Gly 
        1715                1720                1725            

Ser Trp Ile Arg Lys Ala Phe Asn Gly Lys Gly Val Ala Ile Val Lys 
    1730                1735                1740                

Ser Thr Glu Gln Ala Gly Lys Phe Thr Leu Thr Ala His Ser Asp Leu 
1745                1750                1755                1760

Leu Lys Ser Asn Gln Val Thr Val Phe Thr Gly Lys Lys Glu Gly Gln 
                1765                1770                1775    

Glu Lys Thr Val Leu Gly Thr Glu Val Pro Lys Val Gln Thr Ile Ile 
            1780                1785                1790        

Gly Glu Ala Pro Glu Met Pro Thr Thr Val Pro Phe Val Tyr Ser Asp 
        1795                1800                1805            

Gly Ser Arg Ala Glu Arg Pro Val Thr Trp Ser Ser Val Asp Val Ser 
    1810                1815                1820                

Lys Pro Gly Ile Val Thr Val Lys Gly Met Ala Asp Gly Arg Glu Val 
1825                1830                1835                1840

Glu Ala Arg Val Glu Val Ile Ala Leu Lys Ser Glu Leu Pro Val Val 
                1845                1850                1855    

Lys Arg Ile Ala Pro Asn Thr Asp Leu Asn Ser Val Asp Lys Ser Val 
            1860                1865                1870        

Ser Tyr Val Leu Ile Asp Gly Ser Val Glu Glu Tyr Glu Val Asp Lys 
        1875                1880                1885            

Trp Glu Ile Ala Glu Glu Asp Lys Ala Lys Ala Ala Ala Leu Glu His 
    1890                1895                1900                

His His His His His 
1905                

<210>   214
<211>   1944
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Hybrid polypeptide

<400>   214
Met Ala Ser Glu Thr Pro Glu Thr Ser Pro Ala Ile Gly Lys Val Val 
1               5                   10                  15      

Ile Lys Glu Thr Gly Glu Gly Gly Ala Leu Leu Gly Asp Ala Val Phe 
            20                  25                  30          

Glu Leu Lys Asn Asn Thr Asp Gly Thr Thr Val Ser Gln Arg Thr Glu 
        35                  40                  45              

Ala Gln Thr Gly Glu Ala Ile Phe Ser Asn Ile Lys Pro Gly Thr Tyr 
    50                  55                  60                  

Thr Leu Thr Glu Ala Gln Pro Pro Val Gly Tyr Lys Pro Ser Thr Lys 
65                  70                  75                  80  

Gln Trp Thr Val Glu Val Glu Lys Asn Gly Arg Thr Thr Val Gln Gly 
                85                  90                  95      

Glu Gln Val Glu Asn Arg Glu Glu Ala Leu Ser Asp Gln Tyr Pro Gln 
            100                 105                 110         

Thr Gly Thr Tyr Pro Asp Val Gln Thr Pro Tyr Gln Ile Ile Lys Val 
        115                 120                 125             

Asp Gly Ser Glu Lys Asn Gly Gln His Lys Ala Leu Asn Pro Asn Pro 
    130                 135                 140                 

Tyr Glu Arg Val Ile Pro Glu Gly Thr Leu Ser Lys Arg Ile Tyr Gln 
145                 150                 155                 160 

Val Asn Asn Leu Asp Asp Asn Gln Tyr Gly Ile Glu Leu Thr Val Ser 
                165                 170                 175     

Gly Lys Thr Val Tyr Glu Gln Lys Asp Lys Ser Val Pro Leu Asp Val 
            180                 185                 190         

Val Ile Leu Leu Asp Asn Ser Asn Ser Met Ser Asn Ile Arg Asn Lys 
        195                 200                 205             

Asn Ala Arg Arg Ala Glu Arg Ala Gly Glu Ala Thr Arg Ser Leu Ile 
    210                 215                 220                 

Asp Lys Ile Thr Ser Asp Ser Glu Asn Arg Val Ala Leu Val Thr Tyr 
225                 230                 235                 240 

Ala Ser Thr Ile Phe Asp Gly Thr Glu Phe Thr Val Glu Lys Gly Val 
                245                 250                 255     

Ala Asp Lys Asn Gly Lys Arg Leu Asn Asp Ser Leu Phe Trp Asn Tyr 
            260                 265                 270         

Asp Gln Thr Ser Phe Thr Thr Asn Thr Lys Asp Tyr Ser Tyr Leu Lys 
        275                 280                 285             

Leu Thr Asn Asp Lys Asn Asp Ile Val Glu Leu Lys Asn Lys Val Pro 
    290                 295                 300                 

Thr Glu Ala Glu Asp His Asp Gly Asn Arg Leu Met Tyr Gln Phe Gly 
305                 310                 315                 320 

Ala Thr Phe Thr Gln Lys Ala Leu Met Lys Ala Asp Glu Ile Leu Thr 
                325                 330                 335     

Gln Gln Ala Arg Gln Asn Ser Gln Lys Val Ile Phe His Ile Thr Asp 
            340                 345                 350         

Gly Val Pro Thr Met Ser Tyr Pro Ile Asn Phe Asn His Ala Thr Phe 
        355                 360                 365             

Ala Pro Ser Tyr Gln Asn Gln Leu Asn Ala Phe Phe Ser Lys Ser Pro 
    370                 375                 380                 

Asn Lys Asp Gly Ile Leu Leu Ser Asp Phe Ile Thr Gln Ala Thr Ser 
385                 390                 395                 400 

Gly Glu His Thr Ile Val Arg Gly Asp Gly Gln Ser Tyr Gln Met Phe 
                405                 410                 415     

Thr Asp Lys Thr Val Tyr Glu Lys Gly Ala Pro Ala Ala Phe Pro Val 
            420                 425                 430         

Lys Pro Glu Lys Tyr Ser Glu Met Lys Ala Ala Gly Tyr Ala Val Ile 
        435                 440                 445             

Gly Asp Pro Ile Asn Gly Gly Tyr Ile Trp Leu Asn Trp Arg Glu Ser 
    450                 455                 460                 

Ile Leu Ala Tyr Pro Phe Asn Ser Asn Thr Ala Lys Ile Thr Asn His 
465                 470                 475                 480 

Gly Asp Pro Thr Arg Trp Tyr Tyr Asn Gly Asn Ile Ala Pro Asp Gly 
                485                 490                 495     

Tyr Asp Val Phe Thr Val Gly Ile Gly Ile Asn Gly Asp Pro Gly Thr 
            500                 505                 510         

Asp Glu Ala Thr Ala Thr Ser Phe Met Gln Ser Ile Ser Ser Lys Pro 
        515                 520                 525             

Glu Asn Tyr Thr Asn Val Thr Asp Thr Thr Lys Ile Leu Glu Gln Leu 
    530                 535                 540                 

Asn Arg Tyr Phe His Thr Ile Val Thr Glu Lys Lys Ser Ile Glu Asn 
545                 550                 555                 560 

Gly Thr Ile Thr Asp Pro Met Gly Glu Leu Ile Asp Leu Gln Leu Gly 
                565                 570                 575     

Thr Asp Gly Arg Phe Asp Pro Ala Asp Tyr Thr Leu Thr Ala Asn Asp 
            580                 585                 590         

Gly Ser Arg Leu Glu Asn Gly Gln Ala Val Gly Gly Pro Gln Asn Asp 
        595                 600                 605             

Gly Gly Leu Leu Lys Asn Ala Lys Val Leu Tyr Asp Thr Thr Glu Lys 
    610                 615                 620                 

Arg Ile Arg Val Thr Gly Leu Tyr Leu Gly Thr Asp Glu Lys Val Thr 
625                 630                 635                 640 

Leu Thr Tyr Asn Val Arg Leu Asn Asp Glu Phe Val Ser Asn Lys Phe 
                645                 650                 655     

Tyr Asp Thr Asn Gly Arg Thr Thr Leu His Pro Lys Glu Val Glu Gln 
            660                 665                 670         

Asn Thr Val Arg Asp Phe Pro Ile Pro Lys Ile Arg Asp Val Arg Lys 
        675                 680                 685             

Tyr Pro Glu Ile Thr Ile Ser Lys Glu Lys Lys Leu Gly Asp Ile Glu 
    690                 695                 700                 

Phe Ile Lys Val Asn Lys Asn Asp Lys Lys Pro Leu Arg Gly Ala Val 
705                 710                 715                 720 

Phe Ser Leu Gln Lys Gln His Pro Asp Tyr Pro Asp Ile Tyr Gly Ala 
                725                 730                 735     

Ile Asp Gln Asn Gly Thr Tyr Gln Asn Val Arg Thr Gly Glu Asp Gly 
            740                 745                 750         

Lys Leu Thr Phe Lys Asn Leu Ser Asp Gly Lys Tyr Arg Leu Phe Glu 
        755                 760                 765             

Asn Ser Glu Pro Ala Gly Tyr Lys Pro Val Gln Asn Lys Pro Ile Val 
    770                 775                 780                 

Ala Phe Gln Ile Val Asn Gly Glu Val Arg Asp Val Thr Ser Ile Val 
785                 790                 795                 800 

Pro Gln Asp Ile Pro Ala Gly Tyr Glu Phe Thr Asn Asp Lys His Tyr 
                805                 810                 815     

Ile Thr Asn Glu Pro Ile Pro Pro Lys Arg Glu Gly Ser Gly Ser Gly 
            820                 825                 830         

Gly Gly Gly Ile Ala Glu Glu Asp Lys Ala Lys Leu Ala Ile Pro Gly 
        835                 840                 845             

Ser Arg Ile Gln Ala Thr Gly Tyr Leu Glu Gly Gln Pro Ile His Ala 
    850                 855                 860                 

Thr Leu Val Val Glu Glu Gly Asn Pro Ala Ala Pro Ala Val Pro Thr 
865                 870                 875                 880 

Val Thr Val Gly Gly Glu Ala Val Thr Gly Leu Thr Ser Gln Lys Pro 
                885                 890                 895     

Met Gln Tyr Arg Thr Leu Ala Tyr Gly Ala Lys Leu Pro Glu Val Thr 
            900                 905                 910         

Ala Ser Ala Lys Asn Ala Ala Val Thr Val Leu Gln Ala Ser Ala Ala 
        915                 920                 925             

Asn Gly Met Arg Ala Ser Ile Phe Ile Gln Pro Lys Asp Gly Gly Pro 
    930                 935                 940                 

Leu Gln Thr Tyr Ala Ile Gln Phe Leu Glu Glu Ala Pro Lys Ile Ala 
945                 950                 955                 960 

His Leu Ser Leu Gln Val Glu Lys Ala Asp Ser Leu Lys Glu Asp Gln 
                965                 970                 975     

Thr Val Lys Leu Ser Val Arg Ala His Tyr Gln Asp Gly Thr Gln Ala 
            980                 985                 990         

Val Leu Pro Ala Asp Lys Val Thr Phe Ser Thr Ser Gly Glu Gly Glu 
        995                 1000                1005            

Val Ala Ile Arg Lys Gly Met Leu Glu Leu His Lys Pro Gly Ala Val 
    1010                1015                1020                

Thr Leu Asn Ala Glu Tyr Glu Gly Ala Lys Asp Gln Val Glu Leu Thr 
1025                1030                1035                1040

Ile Gln Ala Asn Thr Glu Lys Lys Ile Ala Gln Ser Ile Arg Pro Val 
                1045                1050                1055    

Asn Val Val Thr Asp Leu His Gln Glu Pro Ser Leu Pro Ala Thr Val 
            1060                1065                1070        

Thr Val Glu Tyr Asp Lys Gly Phe Pro Lys Thr His Lys Val Thr Trp 
        1075                1080                1085            

Gln Ala Ile Pro Lys Glu Lys Leu Asp Ser Tyr Gln Thr Phe Glu Val 
    1090                1095                1100                

Leu Gly Lys Val Glu Gly Ile Asp Leu Glu Ala Arg Ala Lys Val Ser 
1105                1110                1115                1120

Val Glu Gly Ile Val Ser Val Glu Glu Val Ser Val Thr Thr Pro Ile 
                1125                1130                1135    

Ala Glu Ala Pro Gln Leu Pro Glu Ser Val Arg Thr Tyr Asp Ser Asn 
            1140                1145                1150        

Gly His Val Ser Ser Ala Lys Val Ala Trp Asp Ala Ile Arg Pro Glu 
        1155                1160                1165            

Gln Tyr Ala Lys Glu Gly Val Phe Thr Val Asn Gly Arg Leu Glu Gly 
    1170                1175                1180                

Thr Gln Leu Thr Thr Lys Leu His Val Arg Val Ser Ala Gln Thr Glu 
1185                1190                1195                1200

Gln Gly Ala Asn Ile Ser Asp Gln Trp Thr Gly Ser Glu Leu Pro Leu 
                1205                1210                1215    

Ala Phe Ala Ser Asp Ser Asn Pro Ser Asp Pro Val Ser Asn Val Asn 
            1220                1225                1230        

Asp Lys Leu Ile Ser Tyr Asn Asn Gln Pro Ala Asn Arg Trp Thr Asn 
        1235                1240                1245            

Trp Asn Arg Thr Asn Pro Glu Ala Ser Val Gly Val Leu Phe Gly Asp 
    1250                1255                1260                

Ser Gly Ile Leu Ser Lys Arg Ser Val Asp Asn Leu Ser Val Gly Phe 
1265                1270                1275                1280

His Glu Asp His Gly Val Gly Val Pro Lys Ser Tyr Val Ile Glu Tyr 
                1285                1290                1295    

Tyr Val Gly Lys Thr Val Pro Thr Ala Pro Lys Asn Pro Ser Phe Val 
            1300                1305                1310        

Gly Asn Glu Asp His Val Phe Asn Asp Ser Ala Asn Trp Lys Pro Val 
        1315                1320                1325            

Thr Asn Leu Lys Ala Pro Ala Gln Leu Lys Ala Gly Glu Met Asn His 
    1330                1335                1340                

Phe Ser Phe Asp Lys Val Glu Thr Tyr Ala Val Arg Ile Arg Met Val 
1345                1350                1355                1360

Lys Ala Asp Asn Lys Arg Gly Thr Ser Ile Thr Glu Val Gln Ile Phe 
                1365                1370                1375    

Ala Lys Gln Val Ala Ala Ala Lys Gln Gly Gln Thr Arg Ile Gln Val 
            1380                1385                1390        

Asp Gly Lys Asp Leu Ala Asn Phe Asn Pro Asp Leu Thr Asp Tyr Tyr 
        1395                1400                1405            

Leu Glu Ser Val Asp Gly Lys Val Pro Ala Val Thr Ala Ser Val Ser 
    1410                1415                1420                

Asn Asn Gly Leu Ala Thr Val Val Pro Ser Val Arg Glu Gly Glu Pro 
1425                1430                1435                1440

Val Arg Val Ile Ala Lys Ala Glu Asn Gly Asp Ile Leu Gly Glu Tyr 
                1445                1450                1455    

Arg Leu His Phe Thr Lys Asp Lys Ser Leu Leu Ser His Lys Pro Val 
            1460                1465                1470        

Ala Ala Val Lys Gln Ala Arg Leu Leu Gln Val Gly Gln Ala Leu Glu 
        1475                1480                1485            

Leu Pro Thr Lys Val Pro Val Tyr Phe Thr Gly Lys Asp Gly Tyr Glu 
    1490                1495                1500                

Thr Lys Asp Leu Thr Val Glu Trp Glu Glu Val Pro Ala Glu Asn Leu 
1505                1510                1515                1520

Thr Lys Ala Gly Gln Phe Thr Val Arg Gly Arg Val Leu Gly Ser Asn 
                1525                1530                1535    

Leu Val Ala Glu Ile Thr Val Arg Val Thr Asp Lys Leu Gly Glu Thr 
            1540                1545                1550        

Leu Ser Asp Asn Pro Asn Tyr Asp Glu Asn Ser Asn Gln Ala Phe Ala 
        1555                1560                1565            

Ser Ala Thr Asn Asp Ile Asp Lys Asn Ser His Asp Arg Val Asp Tyr 
    1570                1575                1580                

Leu Asn Asp Gly Asp His Ser Glu Asn Arg Arg Trp Thr Asn Trp Ser 
1585                1590                1595                1600

Pro Thr Pro Ser Ser Asn Pro Glu Val Ser Ala Gly Val Ile Phe Arg 
                1605                1610                1615    

Glu Asn Gly Lys Ile Val Glu Arg Thr Val Thr Gln Gly Lys Val Gln 
            1620                1625                1630        

Phe Phe Ala Asp Ser Gly Thr Asp Ala Pro Ser Lys Leu Val Leu Glu 
        1635                1640                1645            

Arg Tyr Val Gly Pro Glu Phe Glu Val Pro Thr Tyr Tyr Ser Asn Tyr 
    1650                1655                1660                

Gln Ala Tyr Asp Ala Asp His Pro Phe Asn Asn Pro Glu Asn Trp Glu 
1665                1670                1675                1680

Ala Val Pro Tyr Arg Ala Asp Lys Asp Ile Ala Ala Gly Asp Glu Ile 
                1685                1690                1695    

Asn Val Thr Phe Lys Ala Ile Lys Ala Lys Ala Met Arg Trp Arg Met 
            1700                1705                1710        

Glu Arg Lys Ala Asp Lys Ser Gly Val Ala Met Ile Glu Met Thr Phe 
        1715                1720                1725            

Leu Ala Pro Ser Glu Leu Pro Gln Glu Ser Thr Gln Ser Lys Ile Leu 
    1730                1735                1740                

Val Asp Gly Lys Glu Leu Ala Asp Phe Ala Glu Asn Arg Gln Asp Tyr 
1745                1750                1755                1760

Gln Ile Thr Tyr Lys Gly Gln Arg Pro Lys Val Ser Val Glu Glu Asn 
                1765                1770                1775    

Asn Gln Val Ala Ser Thr Val Val Asp Ser Gly Glu Asp Ser Phe Pro 
            1780                1785                1790        

Val Leu Val Arg Leu Val Ser Glu Ser Gly Lys Gln Val Lys Glu Tyr 
        1795                1800                1805            

Arg Ile His Leu Thr Lys Glu Lys Pro Val Ser Glu Lys Thr Val Ala 
    1810                1815                1820                

Ala Val Gln Glu Asp Leu Pro Lys Ile Glu Phe Val Glu Lys Asp Leu 
1825                1830                1835                1840

Ala Tyr Lys Thr Val Glu Lys Lys Asp Ser Thr Leu Tyr Leu Gly Glu 
                1845                1850                1855    

Thr Arg Val Glu Gln Glu Gly Lys Val Gly Lys Glu Arg Ile Phe Thr 
            1860                1865                1870        

Ala Ile Asn Pro Asp Gly Ser Lys Glu Glu Lys Leu Arg Glu Val Val 
        1875                1880                1885            

Glu Val Pro Thr Asp Arg Ile Val Leu Val Gly Thr Lys Pro Val Ala 
    1890                1895                1900                

Gln Glu Ala Lys Lys Pro Gln Val Ser Glu Lys Ala Asp Thr Lys Pro 
1905                1910                1915                1920

Ile Asp Ser Ser Glu Ala Ser Gln Thr Asn Lys Ala Gln Ala Ala Ala 
                1925                1930                1935    

Leu Glu His His His His His His 
            1940                

<210>   215
<211>   2090
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Hybrid polypeptide

<400>   215
Met Ala Ser Glu Thr Pro Glu Thr Ser Pro Ala Ile Gly Lys Val Val 
1               5                   10                  15      

Ile Lys Glu Thr Gly Glu Gly Gly Ala Leu Leu Gly Asp Ala Val Phe 
            20                  25                  30          

Glu Leu Lys Asn Asn Thr Asp Gly Thr Thr Val Ser Gln Arg Thr Glu 
        35                  40                  45              

Ala Gln Thr Gly Glu Ala Ile Phe Ser Asn Ile Lys Pro Gly Thr Tyr 
    50                  55                  60                  

Thr Leu Thr Glu Ala Gln Pro Pro Val Gly Tyr Lys Pro Ser Thr Lys 
65                  70                  75                  80  

Gln Trp Thr Val Glu Val Glu Lys Asn Gly Arg Thr Thr Val Gln Gly 
                85                  90                  95      

Glu Gln Val Glu Asn Arg Glu Glu Ala Leu Ser Asp Gln Tyr Pro Gln 
            100                 105                 110         

Thr Gly Thr Tyr Pro Asp Val Gln Thr Pro Tyr Gln Ile Ile Lys Val 
        115                 120                 125             

Asp Gly Ser Glu Lys Asn Gly Gln His Lys Ala Leu Asn Pro Asn Pro 
    130                 135                 140                 

Tyr Glu Arg Val Ile Pro Glu Gly Thr Leu Ser Lys Arg Ile Tyr Gln 
145                 150                 155                 160 

Val Asn Asn Leu Asp Asp Asn Gln Tyr Gly Ile Glu Leu Thr Val Ser 
                165                 170                 175     

Gly Lys Thr Val Tyr Glu Gln Lys Asp Lys Ser Val Pro Leu Asp Val 
            180                 185                 190         

Val Ile Leu Leu Asp Asn Ser Asn Ser Met Ser Asn Ile Arg Asn Lys 
        195                 200                 205             

Asn Ala Arg Arg Ala Glu Arg Ala Gly Glu Ala Thr Arg Ser Leu Ile 
    210                 215                 220                 

Asp Lys Ile Thr Ser Asp Ser Glu Asn Arg Val Ala Leu Val Thr Tyr 
225                 230                 235                 240 

Ala Ser Thr Ile Phe Asp Gly Thr Glu Phe Thr Val Glu Lys Gly Val 
                245                 250                 255     

Ala Asp Lys Asn Gly Lys Arg Leu Asn Asp Ser Leu Phe Trp Asn Tyr 
            260                 265                 270         

Asp Gln Thr Ser Phe Thr Thr Asn Thr Lys Asp Tyr Ser Tyr Leu Lys 
        275                 280                 285             

Leu Thr Asn Asp Lys Asn Asp Ile Val Glu Leu Lys Asn Lys Val Pro 
    290                 295                 300                 

Thr Glu Ala Glu Asp His Asp Gly Asn Arg Leu Met Tyr Gln Phe Gly 
305                 310                 315                 320 

Ala Thr Phe Thr Gln Lys Ala Leu Met Lys Ala Asp Glu Ile Leu Thr 
                325                 330                 335     

Gln Gln Ala Arg Gln Asn Ser Gln Lys Val Ile Phe His Ile Thr Asp 
            340                 345                 350         

Gly Val Pro Thr Met Ser Tyr Pro Ile Asn Phe Asn His Ala Thr Phe 
        355                 360                 365             

Ala Pro Ser Tyr Gln Asn Gln Leu Asn Ala Phe Phe Ser Lys Ser Pro 
    370                 375                 380                 

Asn Lys Asp Gly Ile Leu Leu Ser Asp Phe Ile Thr Gln Ala Thr Ser 
385                 390                 395                 400 

Gly Glu His Thr Ile Val Arg Gly Asp Gly Gln Ser Tyr Gln Met Phe 
                405                 410                 415     

Thr Asp Lys Thr Val Tyr Glu Lys Gly Ala Pro Ala Ala Phe Pro Val 
            420                 425                 430         

Lys Pro Glu Lys Tyr Ser Glu Met Lys Ala Ala Gly Tyr Ala Val Ile 
        435                 440                 445             

Gly Asp Pro Ile Asn Gly Gly Tyr Ile Trp Leu Asn Trp Arg Glu Ser 
    450                 455                 460                 

Ile Leu Ala Tyr Pro Phe Asn Ser Asn Thr Ala Lys Ile Thr Asn His 
465                 470                 475                 480 

Gly Asp Pro Thr Arg Trp Tyr Tyr Asn Gly Asn Ile Ala Pro Asp Gly 
                485                 490                 495     

Tyr Asp Val Phe Thr Val Gly Ile Gly Ile Asn Gly Asp Pro Gly Thr 
            500                 505                 510         

Asp Glu Ala Thr Ala Thr Ser Phe Met Gln Ser Ile Ser Ser Lys Pro 
        515                 520                 525             

Glu Asn Tyr Thr Asn Val Thr Asp Thr Thr Lys Ile Leu Glu Gln Leu 
    530                 535                 540                 

Asn Arg Tyr Phe His Thr Ile Val Thr Glu Lys Lys Ser Ile Glu Asn 
545                 550                 555                 560 

Gly Thr Ile Thr Asp Pro Met Gly Glu Leu Ile Asp Leu Gln Leu Gly 
                565                 570                 575     

Thr Asp Gly Arg Phe Asp Pro Ala Asp Tyr Thr Leu Thr Ala Asn Asp 
            580                 585                 590         

Gly Ser Arg Leu Glu Asn Gly Gln Ala Val Gly Gly Pro Gln Asn Asp 
        595                 600                 605             

Gly Gly Leu Leu Lys Asn Ala Lys Val Leu Tyr Asp Thr Thr Glu Lys 
    610                 615                 620                 

Arg Ile Arg Val Thr Gly Leu Tyr Leu Gly Thr Asp Glu Lys Val Thr 
625                 630                 635                 640 

Leu Thr Tyr Asn Val Arg Leu Asn Asp Glu Phe Val Ser Asn Lys Phe 
                645                 650                 655     

Tyr Asp Thr Asn Gly Arg Thr Thr Leu His Pro Lys Glu Val Glu Gln 
            660                 665                 670         

Asn Thr Val Arg Asp Phe Pro Ile Pro Lys Ile Arg Asp Val Arg Lys 
        675                 680                 685             

Tyr Pro Glu Ile Thr Ile Ser Lys Glu Lys Lys Leu Gly Asp Ile Glu 
    690                 695                 700                 

Phe Ile Lys Val Asn Lys Asn Asp Lys Lys Pro Leu Arg Gly Ala Val 
705                 710                 715                 720 

Phe Ser Leu Gln Lys Gln His Pro Asp Tyr Pro Asp Ile Tyr Gly Ala 
                725                 730                 735     

Ile Asp Gln Asn Gly Thr Tyr Gln Asn Val Arg Thr Gly Glu Asp Gly 
            740                 745                 750         

Lys Leu Thr Phe Lys Asn Leu Ser Asp Gly Lys Tyr Arg Leu Phe Glu 
        755                 760                 765             

Asn Ser Glu Pro Ala Gly Tyr Lys Pro Val Gln Asn Lys Pro Ile Val 
    770                 775                 780                 

Ala Phe Gln Ile Val Asn Gly Glu Val Arg Asp Val Thr Ser Ile Val 
785                 790                 795                 800 

Pro Gln Asp Ile Pro Ala Gly Tyr Glu Phe Thr Asn Asp Lys His Tyr 
                805                 810                 815     

Ile Thr Asn Glu Pro Ile Pro Pro Lys Arg Glu Gly Ser Gly Ser Gly 
            820                 825                 830         

Gly Gly Gly Ala Asp Gly Val Thr Pro Thr Thr Thr Glu Asn Gln Pro 
        835                 840                 845             

Thr Ile His Thr Val Ser Asp Ser Pro Gln Ser Ser Glu Asn Arg Thr 
    850                 855                 860                 

Glu Glu Thr Pro Lys Ala Val Leu Gln Pro Glu Ala Pro Lys Thr Val 
865                 870                 875                 880 

Glu Thr Glu Thr Pro Ala Thr Asp Lys Val Ala Ser Leu Pro Lys Thr 
                885                 890                 895     

Glu Glu Lys Pro Gln Glu Glu Val Ser Ser Thr Pro Ser Asp Lys Ala 
            900                 905                 910         

Glu Val Val Thr Pro Thr Ser Ala Glu Lys Glu Thr Ala Asn Lys Lys 
        915                 920                 925             

Ala Glu Glu Ala Ser Pro Lys Lys Glu Glu Ala Lys Glu Val Asp Ser 
    930                 935                 940                 

Lys Glu Ser Asn Thr Asp Lys Thr Asp Lys Asp Lys Pro Ala Lys Lys 
945                 950                 955                 960 

Asp Glu Ala Lys Ala Glu Ala Asp Lys Pro Ala Thr Glu Ala Gly Lys 
                965                 970                 975     

Glu Arg Ala Ala Thr Val Asn Glu Lys Leu Ala Lys Lys Lys Ile Val 
            980                 985                 990         

Ser Ile Asp Ala Gly Arg Lys Tyr Phe Ser Pro Glu Gln Leu Lys Glu 
        995                 1000                1005            

Ile Ile Asp Lys Ala Lys His Tyr Gly Tyr Thr Asp Leu His Leu Leu 
    1010                1015                1020                

Val Gly Asn Asp Gly Leu Arg Phe Met Leu Asp Asp Met Ser Ile Thr 
1025                1030                1035                1040

Ala Asn Gly Lys Thr Tyr Ala Ser Asp Asp Val Lys Arg Ala Ile Glu 
                1045                1050                1055    

Lys Gly Thr Asn Asp Tyr Tyr Asn Asp Pro Asn Gly Asn His Leu Thr 
            1060                1065                1070        

Glu Ser Gln Met Thr Asp Leu Ile Asn Tyr Ala Lys Asp Lys Gly Ile 
        1075                1080                1085            

Gly Leu Ile Pro Thr Val Asn Ser Pro Gly His Met Asp Ala Ile Leu 
    1090                1095                1100                

Asn Ala Met Lys Glu Leu Gly Ile Gln Asn Pro Asn Phe Ser Tyr Phe 
1105                1110                1115                1120

Gly Lys Lys Ser Ala Arg Thr Val Asp Leu Asp Asn Glu Gln Ala Val 
                1125                1130                1135    

Ala Phe Thr Lys Ala Leu Ile Asp Lys Tyr Ala Ala Tyr Phe Ala Lys 
            1140                1145                1150        

Lys Thr Glu Ile Phe Asn Ile Gly Leu Asp Glu Tyr Ala Asn Asp Ala 
        1155                1160                1165            

Thr Asp Ala Lys Gly Trp Ser Val Leu Gln Ala Asp Lys Tyr Tyr Pro 
    1170                1175                1180                

Asn Glu Gly Tyr Pro Val Lys Gly Tyr Glu Lys Phe Ile Ala Tyr Ala 
1185                1190                1195                1200

Asn Asp Leu Ala Arg Ile Val Lys Ser His Gly Leu Lys Pro Met Ala 
                1205                1210                1215    

Phe Asn Asp Gly Ile Tyr Tyr Asn Ser Asp Thr Ser Phe Gly Ser Phe 
            1220                1225                1230        

Asp Lys Asp Ile Ile Val Ser Met Trp Thr Gly Gly Trp Gly Gly Tyr 
        1235                1240                1245            

Asp Val Ala Ser Ser Lys Leu Leu Ala Glu Lys Gly His Gln Ile Leu 
    1250                1255                1260                

Asn Thr Asn Asp Ala Trp Tyr Tyr Val Leu Gly Arg Asn Ala Asp Gly 
1265                1270                1275                1280

Gln Gly Trp Tyr Asn Leu Asp Gln Gly Leu Asn Gly Ile Lys Asn Thr 
                1285                1290                1295    

Pro Ile Thr Ser Val Pro Lys Thr Glu Gly Ala Asp Ile Pro Ile Ile 
            1300                1305                1310        

Gly Gly Met Val Ala Ala Trp Ala Asp Thr Pro Ser Ala Arg Tyr Ser 
        1315                1320                1325            

Pro Ser Arg Leu Phe Lys Leu Met Arg His Phe Ala Asn Ala Asn Ala 
    1330                1335                1340                

Glu Tyr Phe Ala Ala Asp Tyr Glu Ser Ala Glu Gln Ala Leu Asn Glu 
1345                1350                1355                1360

Val Pro Lys Asp Leu Asn Arg Tyr Thr Ala Glu Ser Val Thr Ala Val 
                1365                1370                1375    

Lys Glu Ala Glu Lys Ala Ile Arg Ser Leu Asp Ser Asn Leu Ser Arg 
            1380                1385                1390        

Ala Gln Gln Asp Thr Ile Asp Gln Ala Ile Ala Lys Leu Gln Glu Thr 
        1395                1400                1405            

Val Asn Asn Leu Thr Leu Thr Pro Glu Ala Gln Lys Glu Glu Glu Ala 
    1410                1415                1420                

Lys Arg Glu Val Glu Lys Leu Ala Lys Asn Lys Val Ile Ser Ile Asp 
1425                1430                1435                1440

Ala Gly Arg Lys Tyr Phe Thr Leu Asn Gln Leu Lys Arg Ile Val Asp 
                1445                1450                1455    

Lys Ala Ser Glu Leu Gly Tyr Ser Asp Val His Leu Leu Leu Gly Asn 
            1460                1465                1470        

Asp Gly Leu Arg Phe Leu Leu Asp Asp Met Thr Ile Thr Ala Asn Gly 
        1475                1480                1485            

Lys Thr Tyr Ala Ser Asp Asp Val Lys Lys Ala Ile Ile Glu Gly Thr 
    1490                1495                1500                

Lys Ala Tyr Tyr Asp Asp Pro Asn Gly Thr Ala Leu Thr Gln Ala Glu 
1505                1510                1515                1520

Val Thr Glu Leu Ile Glu Tyr Ala Lys Ser Lys Asp Ile Gly Leu Ile 
                1525                1530                1535    

Pro Ala Ile Asn Ser Pro Gly His Met Asp Ala Met Leu Val Ala Met 
            1540                1545                1550        

Glu Lys Leu Gly Ile Lys Asn Pro Gln Ala His Phe Asp Lys Val Ser 
        1555                1560                1565            

Lys Thr Thr Met Asp Leu Lys Asn Glu Glu Ala Met Asn Phe Val Lys 
    1570                1575                1580                

Ala Leu Ile Gly Lys Tyr Met Asp Phe Phe Ala Gly Lys Thr Lys Ile 
1585                1590                1595                1600

Phe Asn Phe Gly Thr Asp Glu Tyr Ala Asn Asp Ala Thr Ser Ala Gln 
                1605                1610                1615    

Gly Trp Tyr Tyr Leu Lys Trp Tyr Gln Leu Tyr Gly Lys Phe Ala Glu 
            1620                1625                1630        

Tyr Ala Asn Thr Leu Ala Ala Met Ala Lys Glu Arg Gly Leu Gln Pro 
        1635                1640                1645            

Met Ala Phe Asn Asp Gly Phe Tyr Tyr Glu Asp Lys Asp Asp Val Gln 
    1650                1655                1660                

Phe Asp Lys Asp Val Leu Ile Ser Tyr Trp Ser Lys Gly Trp Trp Gly 
1665                1670                1675                1680

Tyr Asn Leu Ala Ser Pro Gln Tyr Leu Ala Ser Lys Gly Tyr Lys Phe 
                1685                1690                1695    

Leu Asn Thr Asn Gly Asp Trp Tyr Tyr Ile Leu Gly Gln Lys Pro Glu 
            1700                1705                1710        

Asp Gly Gly Gly Phe Leu Lys Lys Ala Ile Glu Asn Thr Gly Lys Thr 
        1715                1720                1725            

Pro Phe Asn Gln Leu Ala Ser Thr Lys Tyr Pro Glu Val Asp Leu Pro 
    1730                1735                1740                

Thr Val Gly Ser Met Leu Ser Ile Trp Ala Asp Arg Pro Ser Ala Glu 
1745                1750                1755                1760

Tyr Lys Glu Glu Glu Ile Phe Glu Leu Met Thr Ala Phe Ala Asp His 
                1765                1770                1775    

Asn Lys Asp Tyr Phe Arg Ala Asn Tyr Asn Ala Leu Arg Glu Glu Leu 
            1780                1785                1790        

Ala Lys Ile Pro Thr Asn Leu Glu Gly Tyr Ser Lys Glu Ser Leu Glu 
        1795                1800                1805            

Ala Leu Asp Ala Ala Lys Thr Ala Leu Asn Tyr Asn Leu Asn Arg Asn 
    1810                1815                1820                

Lys Gln Ala Glu Leu Asp Thr Leu Val Ala Asn Leu Lys Ala Ala Leu 
1825                1830                1835                1840

Gln Gly Leu Lys Pro Ala Val Thr His Ser Gly Ser Leu Asp Glu Asn 
                1845                1850                1855    

Glu Val Ala Ala Asn Val Glu Thr Arg Pro Glu Leu Ile Thr Arg Thr 
            1860                1865                1870        

Glu Glu Ile Pro Phe Glu Val Ile Lys Lys Glu Asn Pro Asn Leu Pro 
        1875                1880                1885            

Ala Gly Gln Glu Asn Ile Ile Thr Ala Gly Val Lys Gly Glu Arg Thr 
    1890                1895                1900                

His Tyr Ile Ser Val Leu Thr Glu Asn Gly Lys Thr Thr Glu Thr Val 
1905                1910                1915                1920

Leu Asp Ser Gln Val Thr Lys Glu Val Ile Asn Gln Val Val Glu Val 
                1925                1930                1935    

Gly Ala Pro Val Thr His Lys Gly Asp Glu Ser Gly Leu Ala Pro Thr 
            1940                1945                1950        

Thr Glu Val Lys Pro Arg Leu Asp Ile Gln Glu Glu Glu Ile Pro Phe 
        1955                1960                1965            

Thr Thr Val Thr Cys Glu Asn Pro Leu Leu Leu Lys Gly Lys Thr Gln 
    1970                1975                1980                

Val Ile Thr Lys Gly Val Asn Gly His Arg Ser Asn Phe Tyr Ser Val 
1985                1990                1995                2000

Ser Thr Ser Ala Asp Gly Lys Glu Val Lys Thr Leu Val Asn Ser Val 
                2005                2010                2015    

Val Ala Gln Glu Ala Val Thr Gln Ile Val Glu Val Gly Thr Met Val 
            2020                2025                2030        

Thr His Val Gly Asp Glu Asn Gly Gln Ala Ala Ile Ala Glu Glu Lys 
        2035                2040                2045            

Pro Lys Leu Glu Ile Pro Ser Gln Pro Ala Pro Ser Thr Ala Pro Ala 
    2050                2055                2060                

Glu Glu Ser Lys Val Leu Pro Gln Asp Pro Ala Pro Val Val Thr Glu 
2065                2070                2075                2080

Lys Lys Leu Glu His His His His His His 
                2085                2090

<210>   216
<211>   1012
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Hybrid polypeptide

<400>   216
Met Ala Ser Glu Thr Pro Glu Thr Ser Pro Ala Ile Gly Lys Val Val 
1               5                   10                  15      

Ile Lys Glu Thr Gly Glu Gly Gly Ala Leu Leu Gly Asp Ala Val Phe 
            20                  25                  30          

Glu Leu Lys Asn Asn Thr Asp Gly Thr Thr Val Ser Gln Arg Thr Glu 
        35                  40                  45              

Ala Gln Thr Gly Glu Ala Ile Phe Ser Asn Ile Lys Pro Gly Thr Tyr 
    50                  55                  60                  

Thr Leu Thr Glu Ala Gln Pro Pro Val Gly Tyr Lys Pro Ser Thr Lys 
65                  70                  75                  80  

Gln Trp Thr Val Glu Val Glu Lys Asn Gly Arg Thr Thr Val Gln Gly 
                85                  90                  95      

Glu Gln Val Glu Asn Arg Glu Glu Ala Leu Ser Asp Gln Tyr Pro Gln 
            100                 105                 110         

Thr Gly Thr Tyr Pro Asp Val Gln Thr Pro Tyr Gln Ile Ile Lys Val 
        115                 120                 125             

Asp Gly Ser Glu Lys Asn Gly Gln His Lys Ala Leu Asn Pro Asn Pro 
    130                 135                 140                 

Tyr Glu Arg Val Ile Pro Glu Gly Thr Leu Ser Lys Arg Ile Tyr Gln 
145                 150                 155                 160 

Val Asn Asn Leu Asp Asp Asn Gln Tyr Gly Ile Glu Leu Thr Val Ser 
                165                 170                 175     

Gly Lys Thr Val Tyr Glu Gln Lys Asp Lys Ser Val Pro Leu Asp Val 
            180                 185                 190         

Val Ile Leu Leu Asp Asn Ser Asn Ser Met Ser Asn Ile Arg Asn Lys 
        195                 200                 205             

Asn Ala Arg Arg Ala Glu Arg Ala Gly Glu Ala Thr Arg Ser Leu Ile 
    210                 215                 220                 

Asp Lys Ile Thr Ser Asp Ser Glu Asn Arg Val Ala Leu Val Thr Tyr 
225                 230                 235                 240 

Ala Ser Thr Ile Phe Asp Gly Thr Glu Phe Thr Val Glu Lys Gly Val 
                245                 250                 255     

Ala Asp Lys Asn Gly Lys Arg Leu Asn Asp Ser Leu Phe Trp Asn Tyr 
            260                 265                 270         

Asp Gln Thr Ser Phe Thr Thr Asn Thr Lys Asp Tyr Ser Tyr Leu Lys 
        275                 280                 285             

Leu Thr Asn Asp Lys Asn Asp Ile Val Glu Leu Lys Asn Lys Val Pro 
    290                 295                 300                 

Thr Glu Ala Glu Asp His Asp Gly Asn Arg Leu Met Tyr Gln Phe Gly 
305                 310                 315                 320 

Ala Thr Phe Thr Gln Lys Ala Leu Met Lys Ala Asp Glu Ile Leu Thr 
                325                 330                 335     

Gln Gln Ala Arg Gln Asn Ser Gln Lys Val Ile Phe His Ile Thr Asp 
            340                 345                 350         

Gly Val Pro Thr Met Ser Tyr Pro Ile Asn Phe Asn His Ala Thr Phe 
        355                 360                 365             

Ala Pro Ser Tyr Gln Asn Gln Leu Asn Ala Phe Phe Ser Lys Ser Pro 
    370                 375                 380                 

Asn Lys Asp Gly Ile Leu Leu Ser Asp Phe Ile Thr Gln Ala Thr Ser 
385                 390                 395                 400 

Gly Glu His Thr Ile Val Arg Gly Asp Gly Gln Ser Tyr Gln Met Phe 
                405                 410                 415     

Thr Asp Lys Thr Val Tyr Glu Lys Gly Ala Pro Ala Ala Phe Pro Val 
            420                 425                 430         

Lys Pro Glu Lys Tyr Ser Glu Met Lys Ala Ala Gly Tyr Ala Val Ile 
        435                 440                 445             

Gly Asp Pro Ile Asn Gly Gly Tyr Ile Trp Leu Asn Trp Arg Glu Ser 
    450                 455                 460                 

Ile Leu Ala Tyr Pro Phe Asn Ser Asn Thr Ala Lys Ile Thr Asn His 
465                 470                 475                 480 

Gly Asp Pro Thr Arg Trp Tyr Tyr Asn Gly Asn Ile Ala Pro Asp Gly 
                485                 490                 495     

Tyr Asp Val Phe Thr Val Gly Ile Gly Ile Asn Gly Asp Pro Gly Thr 
            500                 505                 510         

Asp Glu Ala Thr Ala Thr Ser Phe Met Gln Ser Ile Ser Ser Lys Pro 
        515                 520                 525             

Glu Asn Tyr Thr Asn Val Thr Asp Thr Thr Lys Ile Leu Glu Gln Leu 
    530                 535                 540                 

Asn Arg Tyr Phe His Thr Ile Val Thr Glu Lys Lys Ser Ile Glu Asn 
545                 550                 555                 560 

Gly Thr Ile Thr Asp Pro Met Gly Glu Leu Ile Asp Leu Gln Leu Gly 
                565                 570                 575     

Thr Asp Gly Arg Phe Asp Pro Ala Asp Tyr Thr Leu Thr Ala Asn Asp 
            580                 585                 590         

Gly Ser Arg Leu Glu Asn Gly Gln Ala Val Gly Gly Pro Gln Asn Asp 
        595                 600                 605             

Gly Gly Leu Leu Lys Asn Ala Lys Val Leu Tyr Asp Thr Thr Glu Lys 
    610                 615                 620                 

Arg Ile Arg Val Thr Gly Leu Tyr Leu Gly Thr Asp Glu Lys Val Thr 
625                 630                 635                 640 

Leu Thr Tyr Asn Val Arg Leu Asn Asp Glu Phe Val Ser Asn Lys Phe 
                645                 650                 655     

Tyr Asp Thr Asn Gly Arg Thr Thr Leu His Pro Lys Glu Val Glu Gln 
            660                 665                 670         

Asn Thr Val Arg Asp Phe Pro Ile Pro Lys Ile Arg Asp Val Arg Lys 
        675                 680                 685             

Tyr Pro Glu Ile Thr Ile Ser Lys Glu Lys Lys Leu Gly Asp Ile Glu 
    690                 695                 700                 

Phe Ile Lys Val Asn Lys Asn Asp Lys Lys Pro Leu Arg Gly Ala Val 
705                 710                 715                 720 

Phe Ser Leu Gln Lys Gln His Pro Asp Tyr Pro Asp Ile Tyr Gly Ala 
                725                 730                 735     

Ile Asp Gln Asn Gly Thr Tyr Gln Asn Val Arg Thr Gly Glu Asp Gly 
            740                 745                 750         

Lys Leu Thr Phe Lys Asn Leu Ser Asp Gly Lys Tyr Arg Leu Phe Glu 
        755                 760                 765             

Asn Ser Glu Pro Ala Gly Tyr Lys Pro Val Gln Asn Lys Pro Ile Val 
    770                 775                 780                 

Ala Phe Gln Ile Val Asn Gly Glu Val Arg Asp Val Thr Ser Ile Val 
785                 790                 795                 800 

Pro Gln Asp Ile Pro Ala Gly Tyr Glu Phe Thr Asn Asp Lys His Tyr 
                805                 810                 815     

Ile Thr Asn Glu Pro Ile Pro Pro Lys Arg Glu Gly Ser Gly Ser Gly 
            820                 825                 830         

Gly Gly Gly Val Ser Ala Gln Glu Ser Ser Thr Tyr Thr Val Lys Glu 
        835                 840                 845             

Gly Asp Thr Leu Ser Glu Ile Ala Glu Thr His Asn Thr Thr Val Glu 
    850                 855                 860                 

Lys Leu Ala Glu Asn Asn His Ile Asp Asn Ile His Leu Ile Tyr Val 
865                 870                 875                 880 

Asp Gln Glu Leu Val Ile Asp Gly Pro Val Ala Pro Val Ala Thr Pro 
                885                 890                 895     

Ala Pro Ala Thr Tyr Ala Ala Pro Ala Ala Gln Asp Glu Thr Val Ser 
            900                 905                 910         

Ala Pro Val Ala Glu Thr Pro Val Val Ser Glu Thr Val Val Ser Thr 
        915                 920                 925             

Val Ser Gly Ser Glu Ala Glu Ala Lys Glu Trp Ile Ala Gln Lys Glu 
    930                 935                 940                 

Ser Gly Gly Ser Tyr Thr Ala Thr Asn Gly Arg Tyr Ile Gly Arg Tyr 
945                 950                 955                 960 

Gln Leu Thr Asp Ser Tyr Leu Asn Gly Asp Tyr Ser Ala Glu Asn Gln 
                965                 970                 975     

Glu Arg Val Ala Asp Ala Tyr Val Ala Gly Arg Tyr Gly Ser Trp Thr 
            980                 985                 990         

Ala Ala Lys Asn Phe Trp Leu Asn Asn Gly Trp Tyr Leu Glu His His 
        995                 1000                1005            

His His His His 
    1010        

<210>   217
<211>   3422
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Hybrid polypeptide

<400>   217
Met Ala Ser Asp Glu Thr Leu Ile Thr His Thr Ala Glu Lys Pro Lys 
1               5                   10                  15      

Glu Glu Lys Met Ile Val Glu Glu Lys Ala Asp Lys Ala Leu Glu Thr 
            20                  25                  30          

Lys Asn Ile Val Glu Arg Thr Glu Gln Ser Glu Pro Ser Ser Thr Glu 
        35                  40                  45              

Ala Ile Ala Ser Glu Lys Lys Glu Asp Glu Ala Val Thr Pro Lys Glu 
    50                  55                  60                  

Glu Lys Val Ser Ala Lys Pro Glu Glu Lys Ala Pro Arg Ile Glu Ser 
65                  70                  75                  80  

Gln Ala Ser Asn Gln Glu Lys Pro Leu Lys Glu Asp Ala Lys Ala Val 
                85                  90                  95      

Thr Asn Glu Glu Val Asn Gln Met Ile Glu Asp Arg Lys Val Asp Phe 
            100                 105                 110         

Asn Gln Asn Trp Tyr Phe Lys Leu Asn Ala Asn Ser Lys Glu Ala Ile 
        115                 120                 125             

Lys Pro Asp Ala Asp Val Ser Thr Trp Lys Lys Leu Asp Leu Pro Tyr 
    130                 135                 140                 

Asp Trp Ser Ile Phe Asn Asp Phe Asp His Glu Ser Pro Ala Gln Asn 
145                 150                 155                 160 

Glu Gly Gly Gln Leu Asn Gly Gly Glu Ala Trp Tyr Arg Lys Thr Phe 
                165                 170                 175     

Lys Leu Asp Glu Lys Asp Leu Lys Lys Asn Val Arg Leu Thr Phe Asp 
            180                 185                 190         

Gly Val Tyr Met Asp Ser Gln Val Tyr Val Asn Gly Gln Leu Val Gly 
        195                 200                 205             

His Tyr Pro Asn Gly Tyr Asn Gln Phe Ser Tyr Asp Ile Thr Lys Tyr 
    210                 215                 220                 

Leu Gln Lys Asp Gly Arg Glu Asn Val Ile Ala Val His Ala Val Asn 
225                 230                 235                 240 

Lys Gln Pro Ser Ser Arg Trp Tyr Ser Gly Ser Gly Ile Tyr Arg Asp 
                245                 250                 255     

Val Thr Leu Gln Val Thr Asp Lys Val His Val Glu Lys Asn Gly Thr 
            260                 265                 270         

Thr Ile Leu Thr Pro Lys Leu Glu Glu Gln Gln His Gly Lys Val Glu 
        275                 280                 285             

Thr His Val Thr Ser Lys Ile Val Asn Thr Asp Asp Lys Asp His Glu 
    290                 295                 300                 

Leu Val Ala Glu Tyr Gln Ile Val Glu Arg Gly Gly His Ala Val Thr 
305                 310                 315                 320 

Gly Leu Val Arg Thr Ala Ser Arg Thr Leu Lys Ala His Glu Ser Thr 
                325                 330                 335     

Ser Leu Asp Ala Ile Leu Glu Val Glu Arg Pro Lys Leu Trp Thr Val 
            340                 345                 350         

Leu Asn Asp Lys Pro Ala Leu Tyr Glu Leu Ile Thr Arg Val Tyr Arg 
        355                 360                 365             

Asp Gly Gln Leu Val Asp Ala Lys Lys Asp Leu Phe Gly Tyr Arg Tyr 
    370                 375                 380                 

Tyr His Trp Thr Pro Asn Glu Gly Phe Ser Leu Asn Gly Glu Arg Ile 
385                 390                 395                 400 

Lys Phe His Gly Val Ser Leu His His Asp His Gly Ala Leu Gly Ala 
                405                 410                 415     

Glu Glu Asn Tyr Lys Ala Glu Tyr Arg Arg Leu Lys Gln Met Lys Glu 
            420                 425                 430         

Met Gly Val Asn Ser Ile Arg Thr Thr His Asn Pro Ala Ser Glu Gln 
        435                 440                 445             

Thr Leu Gln Ile Ala Ala Glu Leu Gly Leu Leu Val Gln Glu Glu Ala 
    450                 455                 460                 

Phe Asp Thr Trp Tyr Gly Gly Lys Lys Pro Tyr Asp Tyr Gly Arg Phe 
465                 470                 475                 480 

Phe Glu Lys Asp Ala Thr His Pro Glu Ala Arg Lys Gly Glu Lys Trp 
                485                 490                 495     

Ser Asp Phe Asp Leu Arg Thr Met Val Glu Arg Gly Lys Asn Asn Pro 
            500                 505                 510         

Ala Ile Phe Met Trp Ser Ile Gly Asn Glu Ile Gly Glu Ala Asn Gly 
        515                 520                 525             

Asp Ala His Ser Leu Ala Thr Val Lys Arg Leu Val Lys Val Ile Lys 
    530                 535                 540                 

Asp Val Asp Lys Thr Arg Tyr Val Thr Met Gly Ala Asp Lys Phe Arg 
545                 550                 555                 560 

Phe Gly Asn Gly Ser Gly Gly His Glu Lys Ile Ala Asp Glu Leu Asp 
                565                 570                 575     

Ala Val Gly Phe Asn Tyr Ser Glu Asp Asn Tyr Lys Ala Leu Arg Ala 
            580                 585                 590         

Lys His Pro Lys Trp Leu Ile Tyr Gly Ser Glu Thr Ser Ser Ala Thr 
        595                 600                 605             

Arg Thr Arg Gly Ser Tyr Tyr Arg Pro Glu Arg Glu Leu Lys His Ser 
    610                 615                 620                 

Asn Gly Pro Glu Arg Asn Tyr Glu Gln Ser Asp Tyr Gly Asn Asp Arg 
625                 630                 635                 640 

Val Gly Trp Gly Lys Thr Ala Thr Ala Ser Trp Thr Phe Asp Arg Asp 
                645                 650                 655     

Asn Ala Gly Tyr Ala Gly Gln Phe Ile Trp Thr Gly Thr Asp Tyr Ile 
            660                 665                 670         

Gly Glu Pro Thr Pro Trp His Asn Gln Asn Gln Thr Pro Val Lys Ser 
        675                 680                 685             

Ser Tyr Phe Gly Ile Val Asp Thr Ala Gly Ile Pro Lys His Asp Phe 
    690                 695                 700                 

Tyr Leu Tyr Gln Ser Gln Trp Val Ser Val Lys Lys Lys Pro Met Val 
705                 710                 715                 720 

His Leu Leu Pro His Trp Asn Trp Glu Asn Lys Glu Leu Ala Ser Lys 
                725                 730                 735     

Val Ala Asp Ser Glu Gly Lys Ile Pro Val Arg Ala Tyr Ser Asn Ala 
            740                 745                 750         

Ser Ser Val Glu Leu Phe Leu Asn Gly Lys Ser Leu Gly Leu Lys Thr 
        755                 760                 765             

Phe Asn Lys Lys Gln Thr Ser Asp Gly Arg Thr Tyr Gln Glu Gly Ala 
    770                 775                 780                 

Asn Ala Asn Glu Leu Tyr Leu Glu Trp Lys Val Ala Tyr Gln Pro Gly 
785                 790                 795                 800 

Thr Leu Glu Ala Ile Ala Arg Asp Glu Ser Gly Lys Glu Ile Ala Arg 
                805                 810                 815     

Asp Lys Ile Thr Thr Ala Gly Lys Pro Ala Ala Val Arg Leu Ile Lys 
            820                 825                 830         

Glu Asp His Ala Ile Ala Ala Asp Gly Lys Asp Leu Thr Tyr Ile Tyr 
        835                 840                 845             

Tyr Glu Ile Val Asp Ser Gln Gly Asn Val Val Pro Thr Ala Asn Asn 
    850                 855                 860                 

Leu Val Arg Phe Gln Leu His Gly Gln Gly Gln Leu Val Gly Val Asp 
865                 870                 875                 880 

Asn Gly Glu Gln Ala Ser Arg Glu Arg Tyr Lys Ala Gln Ala Asp Gly 
                885                 890                 895     

Ser Trp Ile Arg Lys Ala Phe Asn Gly Lys Gly Val Ala Ile Val Lys 
            900                 905                 910         

Ser Thr Glu Gln Ala Gly Lys Phe Thr Leu Thr Ala His Ser Asp Leu 
        915                 920                 925             

Leu Lys Ser Asn Gln Val Thr Val Phe Thr Gly Lys Lys Glu Gly Gln 
    930                 935                 940                 

Glu Lys Thr Val Leu Gly Thr Glu Val Pro Lys Val Gln Thr Ile Ile 
945                 950                 955                 960 

Gly Glu Ala Pro Glu Met Pro Thr Thr Val Pro Phe Val Tyr Ser Asp 
                965                 970                 975     

Gly Ser Arg Ala Glu Arg Pro Val Thr Trp Ser Ser Val Asp Val Ser 
            980                 985                 990         

Lys Pro Gly Ile Val Thr Val Lys Gly Met Ala Asp Gly Arg Glu Val 
        995                 1000                1005            

Glu Ala Arg Val Glu Val Ile Ala Leu Lys Ser Glu Leu Pro Val Val 
    1010                1015                1020                

Lys Arg Ile Ala Pro Asn Thr Asp Leu Asn Ser Val Asp Lys Ser Val 
1025                1030                1035                1040

Ser Tyr Val Leu Ile Asp Gly Ser Val Glu Glu Tyr Glu Val Asp Lys 
                1045                1050                1055    

Trp Glu Ile Ala Glu Glu Asp Lys Ala Lys Leu Ala Ile Pro Gly Ser 
            1060                1065                1070        

Arg Ile Gln Ala Thr Gly Tyr Leu Glu Gly Gln Pro Ile His Ala Thr 
        1075                1080                1085            

Leu Val Val Glu Glu Gly Asn Pro Ala Ala Pro Ala Val Pro Thr Val 
    1090                1095                1100                

Thr Val Gly Gly Glu Ala Val Thr Gly Leu Thr Ser Gln Lys Pro Met 
1105                1110                1115                1120

Gln Tyr Arg Thr Leu Ala Tyr Gly Ala Lys Leu Pro Glu Val Thr Ala 
                1125                1130                1135    

Ser Ala Lys Asn Ala Ala Val Thr Val Leu Gln Ala Ser Ala Ala Asn 
            1140                1145                1150        

Gly Met Arg Ala Ser Ile Phe Ile Gln Pro Lys Asp Gly Gly Pro Leu 
        1155                1160                1165            

Gln Thr Tyr Ala Ile Gln Phe Leu Glu Glu Ala Pro Lys Ile Ala His 
    1170                1175                1180                

Leu Ser Leu Gln Val Glu Lys Ala Asp Ser Leu Lys Glu Asp Gln Thr 
1185                1190                1195                1200

Val Lys Leu Ser Val Arg Ala His Tyr Gln Asp Gly Thr Gln Ala Val 
                1205                1210                1215    

Leu Pro Ala Asp Lys Val Thr Phe Ser Thr Ser Gly Glu Gly Glu Val 
            1220                1225                1230        

Ala Ile Arg Lys Gly Met Leu Glu Leu His Lys Pro Gly Ala Val Thr 
        1235                1240                1245            

Leu Asn Ala Glu Tyr Glu Gly Ala Lys Asp Gln Val Glu Leu Thr Ile 
    1250                1255                1260                

Gln Ala Asn Thr Glu Lys Lys Ile Ala Gln Ser Ile Arg Pro Val Asn 
1265                1270                1275                1280

Val Val Thr Asp Leu His Gln Glu Pro Ser Leu Pro Ala Thr Val Thr 
                1285                1290                1295    

Val Glu Tyr Asp Lys Gly Phe Pro Lys Thr His Lys Val Thr Trp Gln 
            1300                1305                1310        

Ala Ile Pro Lys Glu Lys Leu Asp Ser Tyr Gln Thr Phe Glu Val Leu 
        1315                1320                1325            

Gly Lys Val Glu Gly Ile Asp Leu Glu Ala Arg Ala Lys Val Ser Val 
    1330                1335                1340                

Glu Gly Ile Val Ser Val Glu Glu Val Ser Val Thr Thr Pro Ile Ala 
1345                1350                1355                1360

Glu Ala Pro Gln Leu Pro Glu Ser Val Arg Thr Tyr Asp Ser Asn Gly 
                1365                1370                1375    

His Val Ser Ser Ala Lys Val Ala Trp Asp Ala Ile Arg Pro Glu Gln 
            1380                1385                1390        

Tyr Ala Lys Glu Gly Val Phe Thr Val Asn Gly Arg Leu Glu Gly Thr 
        1395                1400                1405            

Gln Leu Thr Thr Lys Leu His Val Arg Val Ser Ala Gln Thr Glu Gln 
    1410                1415                1420                

Gly Ala Asn Ile Ser Asp Gln Trp Thr Gly Ser Glu Leu Pro Leu Ala 
1425                1430                1435                1440

Phe Ala Ser Asp Ser Asn Pro Ser Asp Pro Val Ser Asn Val Asn Asp 
                1445                1450                1455    

Lys Leu Ile Ser Tyr Asn Asn Gln Pro Ala Asn Arg Trp Thr Asn Trp 
            1460                1465                1470        

Asn Arg Thr Asn Pro Glu Ala Ser Val Gly Val Leu Phe Gly Asp Ser 
        1475                1480                1485            

Gly Ile Leu Ser Lys Arg Ser Val Asp Asn Leu Ser Val Gly Phe His 
    1490                1495                1500                

Glu Asp His Gly Val Gly Val Pro Lys Ser Tyr Val Ile Glu Tyr Tyr 
1505                1510                1515                1520

Val Gly Lys Thr Val Pro Thr Ala Pro Lys Asn Pro Ser Phe Val Gly 
                1525                1530                1535    

Asn Glu Asp His Val Phe Asn Asp Ser Ala Asn Trp Lys Pro Val Thr 
            1540                1545                1550        

Asn Leu Lys Ala Pro Ala Gln Leu Lys Ala Gly Glu Met Asn His Phe 
        1555                1560                1565            

Ser Phe Asp Lys Val Glu Thr Tyr Ala Val Arg Ile Arg Met Val Lys 
    1570                1575                1580                

Ala Asp Asn Lys Arg Gly Thr Ser Ile Thr Glu Val Gln Ile Phe Ala 
1585                1590                1595                1600

Lys Gln Val Ala Ala Ala Lys Gln Gly Gln Thr Arg Ile Gln Val Asp 
                1605                1610                1615    

Gly Lys Asp Leu Ala Asn Phe Asn Pro Asp Leu Thr Asp Tyr Tyr Leu 
            1620                1625                1630        

Glu Ser Val Asp Gly Lys Val Pro Ala Val Thr Ala Ser Val Ser Asn 
        1635                1640                1645            

Asn Gly Leu Ala Thr Val Val Pro Ser Val Arg Glu Gly Glu Pro Val 
    1650                1655                1660                

Arg Val Ile Ala Lys Ala Glu Asn Gly Asp Ile Leu Gly Glu Tyr Arg 
1665                1670                1675                1680

Leu His Phe Thr Lys Asp Lys Ser Leu Leu Ser His Lys Pro Val Ala 
                1685                1690                1695    

Ala Val Lys Gln Ala Arg Leu Leu Gln Val Gly Gln Ala Leu Glu Leu 
            1700                1705                1710        

Pro Thr Lys Val Pro Val Tyr Phe Thr Gly Lys Asp Gly Tyr Glu Thr 
        1715                1720                1725            

Lys Asp Leu Thr Val Glu Trp Glu Glu Val Pro Ala Glu Asn Leu Thr 
    1730                1735                1740                

Lys Ala Gly Gln Phe Thr Val Arg Gly Arg Val Leu Gly Ser Asn Leu 
1745                1750                1755                1760

Val Ala Glu Ile Thr Val Arg Val Thr Asp Lys Leu Gly Glu Thr Leu 
                1765                1770                1775    

Ser Asp Asn Pro Asn Tyr Asp Glu Asn Ser Asn Gln Ala Phe Ala Ser 
            1780                1785                1790        

Ala Thr Asn Asp Ile Asp Lys Asn Ser His Asp Arg Val Asp Tyr Leu 
        1795                1800                1805            

Asn Asp Gly Asp His Ser Glu Asn Arg Arg Trp Thr Asn Trp Ser Pro 
    1810                1815                1820                

Thr Pro Ser Ser Asn Pro Glu Val Ser Ala Gly Val Ile Phe Arg Glu 
1825                1830                1835                1840

Asn Gly Lys Ile Val Glu Arg Thr Val Thr Gln Gly Lys Val Gln Phe 
                1845                1850                1855    

Phe Ala Asp Ser Gly Thr Asp Ala Pro Ser Lys Leu Val Leu Glu Arg 
            1860                1865                1870        

Tyr Val Gly Pro Glu Phe Glu Val Pro Thr Tyr Tyr Ser Asn Tyr Gln 
        1875                1880                1885            

Ala Tyr Asp Ala Asp His Pro Phe Asn Asn Pro Glu Asn Trp Glu Ala 
    1890                1895                1900                

Val Pro Tyr Arg Ala Asp Lys Asp Ile Ala Ala Gly Asp Glu Ile Asn 
1905                1910                1915                1920

Val Thr Phe Lys Ala Ile Lys Ala Lys Ala Met Arg Trp Arg Met Glu 
                1925                1930                1935    

Arg Lys Ala Asp Lys Ser Gly Val Ala Met Ile Glu Met Thr Phe Leu 
            1940                1945                1950        

Ala Pro Ser Glu Leu Pro Gln Glu Ser Thr Gln Ser Lys Ile Leu Val 
        1955                1960                1965            

Asp Gly Lys Glu Leu Ala Asp Phe Ala Glu Asn Arg Gln Asp Tyr Gln 
    1970                1975                1980                

Ile Thr Tyr Lys Gly Gln Arg Pro Lys Val Ser Val Glu Glu Asn Asn 
1985                1990                1995                2000

Gln Val Ala Ser Thr Val Val Asp Ser Gly Glu Asp Ser Phe Pro Val 
                2005                2010                2015    

Leu Val Arg Leu Val Ser Glu Ser Gly Lys Gln Val Lys Glu Tyr Arg 
            2020                2025                2030        

Ile His Leu Thr Lys Glu Lys Pro Val Ser Glu Lys Thr Val Ala Ala 
        2035                2040                2045            

Val Gln Glu Asp Leu Pro Lys Ile Glu Phe Val Glu Lys Asp Leu Ala 
    2050                2055                2060                

Tyr Lys Thr Val Glu Lys Lys Asp Ser Thr Leu Tyr Leu Gly Glu Thr 
2065                2070                2075                2080

Arg Val Glu Gln Glu Gly Lys Val Gly Lys Glu Arg Ile Phe Thr Ala 
                2085                2090                2095    

Ile Asn Pro Asp Gly Ser Lys Glu Glu Lys Leu Arg Glu Val Val Glu 
            2100                2105                2110        

Val Pro Thr Asp Arg Ile Val Leu Val Gly Thr Lys Pro Val Ala Gln 
        2115                2120                2125            

Glu Ala Lys Lys Pro Gln Val Ser Glu Lys Ala Asp Thr Lys Pro Ile 
    2130                2135                2140                

Asp Ser Ser Glu Ala Ser Gln Thr Asn Lys Ala Gln Gly Ser Gly Ser 
2145                2150                2155                2160

Gly Gly Gly Gly Ala Asp Gly Val Thr Pro Thr Thr Thr Glu Asn Gln 
                2165                2170                2175    

Pro Thr Ile His Thr Val Ser Asp Ser Pro Gln Ser Ser Glu Asn Arg 
            2180                2185                2190        

Thr Glu Glu Thr Pro Lys Ala Val Leu Gln Pro Glu Ala Pro Lys Thr 
        2195                2200                2205            

Val Glu Thr Glu Thr Pro Ala Thr Asp Lys Val Ala Ser Leu Pro Lys 
    2210                2215                2220                

Thr Glu Glu Lys Pro Gln Glu Glu Val Ser Ser Thr Pro Ser Asp Lys 
2225                2230                2235                2240

Ala Glu Val Val Thr Pro Thr Ser Ala Glu Lys Glu Thr Ala Asn Lys 
                2245                2250                2255    

Lys Ala Glu Glu Ala Ser Pro Lys Lys Glu Glu Ala Lys Glu Val Asp 
            2260                2265                2270        

Ser Lys Glu Ser Asn Thr Asp Lys Thr Asp Lys Asp Lys Pro Ala Lys 
        2275                2280                2285            

Lys Asp Glu Ala Lys Ala Glu Ala Asp Lys Pro Ala Thr Glu Ala Gly 
    2290                2295                2300                

Lys Glu Arg Ala Ala Thr Val Asn Glu Lys Leu Ala Lys Lys Lys Ile 
2305                2310                2315                2320

Val Ser Ile Asp Ala Gly Arg Lys Tyr Phe Ser Pro Glu Gln Leu Lys 
                2325                2330                2335    

Glu Ile Ile Asp Lys Ala Lys His Tyr Gly Tyr Thr Asp Leu His Leu 
            2340                2345                2350        

Leu Val Gly Asn Asp Gly Leu Arg Phe Met Leu Asp Asp Met Ser Ile 
        2355                2360                2365            

Thr Ala Asn Gly Lys Thr Tyr Ala Ser Asp Asp Val Lys Arg Ala Ile 
    2370                2375                2380                

Glu Lys Gly Thr Asn Asp Tyr Tyr Asn Asp Pro Asn Gly Asn His Leu 
2385                2390                2395                2400

Thr Glu Ser Gln Met Thr Asp Leu Ile Asn Tyr Ala Lys Asp Lys Gly 
                2405                2410                2415    

Ile Gly Leu Ile Pro Thr Val Asn Ser Pro Gly His Met Asp Ala Ile 
            2420                2425                2430        

Leu Asn Ala Met Lys Glu Leu Gly Ile Gln Asn Pro Asn Phe Ser Tyr 
        2435                2440                2445            

Phe Gly Lys Lys Ser Ala Arg Thr Val Asp Leu Asp Asn Glu Gln Ala 
    2450                2455                2460                

Val Ala Phe Thr Lys Ala Leu Ile Asp Lys Tyr Ala Ala Tyr Phe Ala 
2465                2470                2475                2480

Lys Lys Thr Glu Ile Phe Asn Ile Gly Leu Asp Glu Tyr Ala Asn Asp 
                2485                2490                2495    

Ala Thr Asp Ala Lys Gly Trp Ser Val Leu Gln Ala Asp Lys Tyr Tyr 
            2500                2505                2510        

Pro Asn Glu Gly Tyr Pro Val Lys Gly Tyr Glu Lys Phe Ile Ala Tyr 
        2515                2520                2525            

Ala Asn Asp Leu Ala Arg Ile Val Lys Ser His Gly Leu Lys Pro Met 
    2530                2535                2540                

Ala Phe Asn Asp Gly Ile Tyr Tyr Asn Ser Asp Thr Ser Phe Gly Ser 
2545                2550                2555                2560

Phe Asp Lys Asp Ile Ile Val Ser Met Trp Thr Gly Gly Trp Gly Gly 
                2565                2570                2575    

Tyr Asp Val Ala Ser Ser Lys Leu Leu Ala Glu Lys Gly His Gln Ile 
            2580                2585                2590        

Leu Asn Thr Asn Asp Ala Trp Tyr Tyr Val Leu Gly Arg Asn Ala Asp 
        2595                2600                2605            

Gly Gln Gly Trp Tyr Asn Leu Asp Gln Gly Leu Asn Gly Ile Lys Asn 
    2610                2615                2620                

Thr Pro Ile Thr Ser Val Pro Lys Thr Glu Gly Ala Asp Ile Pro Ile 
2625                2630                2635                2640

Ile Gly Gly Met Val Ala Ala Trp Ala Asp Thr Pro Ser Ala Arg Tyr 
                2645                2650                2655    

Ser Pro Ser Arg Leu Phe Lys Leu Met Arg His Phe Ala Asn Ala Asn 
            2660                2665                2670        

Ala Glu Tyr Phe Ala Ala Asp Tyr Glu Ser Ala Glu Gln Ala Leu Asn 
        2675                2680                2685            

Glu Val Pro Lys Asp Leu Asn Arg Tyr Thr Ala Glu Ser Val Thr Ala 
    2690                2695                2700                

Val Lys Glu Ala Glu Lys Ala Ile Arg Ser Leu Asp Ser Asn Leu Ser 
2705                2710                2715                2720

Arg Ala Gln Gln Asp Thr Ile Asp Gln Ala Ile Ala Lys Leu Gln Glu 
                2725                2730                2735    

Thr Val Asn Asn Leu Thr Leu Thr Pro Glu Ala Gln Lys Glu Glu Glu 
            2740                2745                2750        

Ala Lys Arg Glu Val Glu Lys Leu Ala Lys Asn Lys Val Ile Ser Ile 
        2755                2760                2765            

Asp Ala Gly Arg Lys Tyr Phe Thr Leu Asn Gln Leu Lys Arg Ile Val 
    2770                2775                2780                

Asp Lys Ala Ser Glu Leu Gly Tyr Ser Asp Val His Leu Leu Leu Gly 
2785                2790                2795                2800

Asn Asp Gly Leu Arg Phe Leu Leu Asp Asp Met Thr Ile Thr Ala Asn 
                2805                2810                2815    

Gly Lys Thr Tyr Ala Ser Asp Asp Val Lys Lys Ala Ile Ile Glu Gly 
            2820                2825                2830        

Thr Lys Ala Tyr Tyr Asp Asp Pro Asn Gly Thr Ala Leu Thr Gln Ala 
        2835                2840                2845            

Glu Val Thr Glu Leu Ile Glu Tyr Ala Lys Ser Lys Asp Ile Gly Leu 
    2850                2855                2860                

Ile Pro Ala Ile Asn Ser Pro Gly His Met Asp Ala Met Leu Val Ala 
2865                2870                2875                2880

Met Glu Lys Leu Gly Ile Lys Asn Pro Gln Ala His Phe Asp Lys Val 
                2885                2890                2895    

Ser Lys Thr Thr Met Asp Leu Lys Asn Glu Glu Ala Met Asn Phe Val 
            2900                2905                2910        

Lys Ala Leu Ile Gly Lys Tyr Met Asp Phe Phe Ala Gly Lys Thr Lys 
        2915                2920                2925            

Ile Phe Asn Phe Gly Thr Asp Glu Tyr Ala Asn Asp Ala Thr Ser Ala 
    2930                2935                2940                

Gln Gly Trp Tyr Tyr Leu Lys Trp Tyr Gln Leu Tyr Gly Lys Phe Ala 
2945                2950                2955                2960

Glu Tyr Ala Asn Thr Leu Ala Ala Met Ala Lys Glu Arg Gly Leu Gln 
                2965                2970                2975    

Pro Met Ala Phe Asn Asp Gly Phe Tyr Tyr Glu Asp Lys Asp Asp Val 
            2980                2985                2990        

Gln Phe Asp Lys Asp Val Leu Ile Ser Tyr Trp Ser Lys Gly Trp Trp 
        2995                3000                3005            

Gly Tyr Asn Leu Ala Ser Pro Gln Tyr Leu Ala Ser Lys Gly Tyr Lys 
    3010                3015                3020                

Phe Leu Asn Thr Asn Gly Asp Trp Tyr Tyr Ile Leu Gly Gln Lys Pro 
3025                3030                3035                3040

Glu Asp Gly Gly Gly Phe Leu Lys Lys Ala Ile Glu Asn Thr Gly Lys 
                3045                3050                3055    

Thr Pro Phe Asn Gln Leu Ala Ser Thr Lys Tyr Pro Glu Val Asp Leu 
            3060                3065                3070        

Pro Thr Val Gly Ser Met Leu Ser Ile Trp Ala Asp Arg Pro Ser Ala 
        3075                3080                3085            

Glu Tyr Lys Glu Glu Glu Ile Phe Glu Leu Met Thr Ala Phe Ala Asp 
    3090                3095                3100                

His Asn Lys Asp Tyr Phe Arg Ala Asn Tyr Asn Ala Leu Arg Glu Glu 
3105                3110                3115                3120

Leu Ala Lys Ile Pro Thr Asn Leu Glu Gly Tyr Ser Lys Glu Ser Leu 
                3125                3130                3135    

Glu Ala Leu Asp Ala Ala Lys Thr Ala Leu Asn Tyr Asn Leu Asn Arg 
            3140                3145                3150        

Asn Lys Gln Ala Glu Leu Asp Thr Leu Val Ala Asn Leu Lys Ala Ala 
        3155                3160                3165            

Leu Gln Gly Leu Lys Pro Ala Val Thr His Ser Gly Ser Leu Asp Glu 
    3170                3175                3180                

Asn Glu Val Ala Ala Asn Val Glu Thr Arg Pro Glu Leu Ile Thr Arg 
3185                3190                3195                3200

Thr Glu Glu Ile Pro Phe Glu Val Ile Lys Lys Glu Asn Pro Asn Leu 
                3205                3210                3215    

Pro Ala Gly Gln Glu Asn Ile Ile Thr Ala Gly Val Lys Gly Glu Arg 
            3220                3225                3230        

Thr His Tyr Ile Ser Val Leu Thr Glu Asn Gly Lys Thr Thr Glu Thr 
        3235                3240                3245            

Val Leu Asp Ser Gln Val Thr Lys Glu Val Ile Asn Gln Val Val Glu 
    3250                3255                3260                

Val Gly Ala Pro Val Thr His Lys Gly Asp Glu Ser Gly Leu Ala Pro 
3265                3270                3275                3280

Thr Thr Glu Val Lys Pro Arg Leu Asp Ile Gln Glu Glu Glu Ile Pro 
                3285                3290                3295    

Phe Thr Thr Val Thr Cys Glu Asn Pro Leu Leu Leu Lys Gly Lys Thr 
            3300                3305                3310        

Gln Val Ile Thr Lys Gly Val Asn Gly His Arg Ser Asn Phe Tyr Ser 
        3315                3320                3325            

Val Ser Thr Ser Ala Asp Gly Lys Glu Val Lys Thr Leu Val Asn Ser 
    3330                3335                3340                

Val Val Ala Gln Glu Ala Val Thr Gln Ile Val Glu Val Gly Thr Met 
3345                3350                3355                3360

Val Thr His Val Gly Asp Glu Asn Gly Gln Ala Ala Ile Ala Glu Glu 
                3365                3370                3375    

Lys Pro Lys Leu Glu Ile Pro Ser Gln Pro Ala Pro Ser Thr Ala Pro 
            3380                3385                3390        

Ala Glu Glu Ser Lys Val Leu Pro Gln Asp Pro Ala Pro Val Val Thr 
        3395                3400                3405            

Glu Lys Lys Ala Ala Ala Leu Glu His His His His His His 
    3410                3415                3420        

<210>   218
<211>   2332
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Hybrid polypeptide

<400>   218
Met Ala Ser Asp Glu Thr Leu Ile Thr His Thr Ala Glu Lys Pro Lys 
1               5                   10                  15      

Glu Glu Lys Met Ile Val Glu Glu Lys Ala Asp Lys Ala Leu Glu Thr 
            20                  25                  30          

Lys Asn Ile Val Glu Arg Thr Glu Gln Ser Glu Pro Ser Ser Thr Glu 
        35                  40                  45              

Ala Ile Ala Ser Glu Lys Lys Glu Asp Glu Ala Val Thr Pro Lys Glu 
    50                  55                  60                  

Glu Lys Val Ser Ala Lys Pro Glu Glu Lys Ala Pro Arg Ile Glu Ser 
65                  70                  75                  80  

Gln Ala Ser Asn Gln Glu Lys Pro Leu Lys Glu Asp Ala Lys Ala Val 
                85                  90                  95      

Thr Asn Glu Glu Val Asn Gln Met Ile Glu Asp Arg Lys Val Asp Phe 
            100                 105                 110         

Asn Gln Asn Trp Tyr Phe Lys Leu Asn Ala Asn Ser Lys Glu Ala Ile 
        115                 120                 125             

Lys Pro Asp Ala Asp Val Ser Thr Trp Lys Lys Leu Asp Leu Pro Tyr 
    130                 135                 140                 

Asp Trp Ser Ile Phe Asn Asp Phe Asp His Glu Ser Pro Ala Gln Asn 
145                 150                 155                 160 

Glu Gly Gly Gln Leu Asn Gly Gly Glu Ala Trp Tyr Arg Lys Thr Phe 
                165                 170                 175     

Lys Leu Asp Glu Lys Asp Leu Lys Lys Asn Val Arg Leu Thr Phe Asp 
            180                 185                 190         

Gly Val Tyr Met Asp Ser Gln Val Tyr Val Asn Gly Gln Leu Val Gly 
        195                 200                 205             

His Tyr Pro Asn Gly Tyr Asn Gln Phe Ser Tyr Asp Ile Thr Lys Tyr 
    210                 215                 220                 

Leu Gln Lys Asp Gly Arg Glu Asn Val Ile Ala Val His Ala Val Asn 
225                 230                 235                 240 

Lys Gln Pro Ser Ser Arg Trp Tyr Ser Gly Ser Gly Ile Tyr Arg Asp 
                245                 250                 255     

Val Thr Leu Gln Val Thr Asp Lys Val His Val Glu Lys Asn Gly Thr 
            260                 265                 270         

Thr Ile Leu Thr Pro Lys Leu Glu Glu Gln Gln His Gly Lys Val Glu 
        275                 280                 285             

Thr His Val Thr Ser Lys Ile Val Asn Thr Asp Asp Lys Asp His Glu 
    290                 295                 300                 

Leu Val Ala Glu Tyr Gln Ile Val Glu Arg Gly Gly His Ala Val Thr 
305                 310                 315                 320 

Gly Leu Val Arg Thr Ala Ser Arg Thr Leu Lys Ala His Glu Ser Thr 
                325                 330                 335     

Ser Leu Asp Ala Ile Leu Glu Val Glu Arg Pro Lys Leu Trp Thr Val 
            340                 345                 350         

Leu Asn Asp Lys Pro Ala Leu Tyr Glu Leu Ile Thr Arg Val Tyr Arg 
        355                 360                 365             

Asp Gly Gln Leu Val Asp Ala Lys Lys Asp Leu Phe Gly Tyr Arg Tyr 
    370                 375                 380                 

Tyr His Trp Thr Pro Asn Glu Gly Phe Ser Leu Asn Gly Glu Arg Ile 
385                 390                 395                 400 

Lys Phe His Gly Val Ser Leu His His Asp His Gly Ala Leu Gly Ala 
                405                 410                 415     

Glu Glu Asn Tyr Lys Ala Glu Tyr Arg Arg Leu Lys Gln Met Lys Glu 
            420                 425                 430         

Met Gly Val Asn Ser Ile Arg Thr Thr His Asn Pro Ala Ser Glu Gln 
        435                 440                 445             

Thr Leu Gln Ile Ala Ala Glu Leu Gly Leu Leu Val Gln Glu Glu Ala 
    450                 455                 460                 

Phe Asp Thr Trp Tyr Gly Gly Lys Lys Pro Tyr Asp Tyr Gly Arg Phe 
465                 470                 475                 480 

Phe Glu Lys Asp Ala Thr His Pro Glu Ala Arg Lys Gly Glu Lys Trp 
                485                 490                 495     

Ser Asp Phe Asp Leu Arg Thr Met Val Glu Arg Gly Lys Asn Asn Pro 
            500                 505                 510         

Ala Ile Phe Met Trp Ser Ile Gly Asn Glu Ile Gly Glu Ala Asn Gly 
        515                 520                 525             

Asp Ala His Ser Leu Ala Thr Val Lys Arg Leu Val Lys Val Ile Lys 
    530                 535                 540                 

Asp Val Asp Lys Thr Arg Tyr Val Thr Met Gly Ala Asp Lys Phe Arg 
545                 550                 555                 560 

Phe Gly Asn Gly Ser Gly Gly His Glu Lys Ile Ala Asp Glu Leu Asp 
                565                 570                 575     

Ala Val Gly Phe Asn Tyr Ser Glu Asp Asn Tyr Lys Ala Leu Arg Ala 
            580                 585                 590         

Lys His Pro Lys Trp Leu Ile Tyr Gly Ser Glu Thr Ser Ser Ala Thr 
        595                 600                 605             

Arg Thr Arg Gly Ser Tyr Tyr Arg Pro Glu Arg Glu Leu Lys His Ser 
    610                 615                 620                 

Asn Gly Pro Glu Arg Asn Tyr Glu Gln Ser Asp Tyr Gly Asn Asp Arg 
625                 630                 635                 640 

Val Gly Trp Gly Lys Thr Ala Thr Ala Ser Trp Thr Phe Asp Arg Asp 
                645                 650                 655     

Asn Ala Gly Tyr Ala Gly Gln Phe Ile Trp Thr Gly Thr Asp Tyr Ile 
            660                 665                 670         

Gly Glu Pro Thr Pro Trp His Asn Gln Asn Gln Thr Pro Val Lys Ser 
        675                 680                 685             

Ser Tyr Phe Gly Ile Val Asp Thr Ala Gly Ile Pro Lys His Asp Phe 
    690                 695                 700                 

Tyr Leu Tyr Gln Ser Gln Trp Val Ser Val Lys Lys Lys Pro Met Val 
705                 710                 715                 720 

His Leu Leu Pro His Trp Asn Trp Glu Asn Lys Glu Leu Ala Ser Lys 
                725                 730                 735     

Val Ala Asp Ser Glu Gly Lys Ile Pro Val Arg Ala Tyr Ser Asn Ala 
            740                 745                 750         

Ser Ser Val Glu Leu Phe Leu Asn Gly Lys Ser Leu Gly Leu Lys Thr 
        755                 760                 765             

Phe Asn Lys Lys Gln Thr Ser Asp Gly Arg Thr Tyr Gln Glu Gly Ala 
    770                 775                 780                 

Asn Ala Asn Glu Leu Tyr Leu Glu Trp Lys Val Ala Tyr Gln Pro Gly 
785                 790                 795                 800 

Thr Leu Glu Ala Ile Ala Arg Asp Glu Ser Gly Lys Glu Ile Ala Arg 
                805                 810                 815     

Asp Lys Ile Thr Thr Ala Gly Lys Pro Ala Ala Val Arg Leu Ile Lys 
            820                 825                 830         

Glu Asp His Ala Ile Ala Ala Asp Gly Lys Asp Leu Thr Tyr Ile Tyr 
        835                 840                 845             

Tyr Glu Ile Val Asp Ser Gln Gly Asn Val Val Pro Thr Ala Asn Asn 
    850                 855                 860                 

Leu Val Arg Phe Gln Leu His Gly Gln Gly Gln Leu Val Gly Val Asp 
865                 870                 875                 880 

Asn Gly Glu Gln Ala Ser Arg Glu Arg Tyr Lys Ala Gln Ala Asp Gly 
                885                 890                 895     

Ser Trp Ile Arg Lys Ala Phe Asn Gly Lys Gly Val Ala Ile Val Lys 
            900                 905                 910         

Ser Thr Glu Gln Ala Gly Lys Phe Thr Leu Thr Ala His Ser Asp Leu 
        915                 920                 925             

Leu Lys Ser Asn Gln Val Thr Val Phe Thr Gly Lys Lys Glu Gly Gln 
    930                 935                 940                 

Glu Lys Thr Val Leu Gly Thr Glu Val Pro Lys Val Gln Thr Ile Ile 
945                 950                 955                 960 

Gly Glu Ala Pro Glu Met Pro Thr Thr Val Pro Phe Val Tyr Ser Asp 
                965                 970                 975     

Gly Ser Arg Ala Glu Arg Pro Val Thr Trp Ser Ser Val Asp Val Ser 
            980                 985                 990         

Lys Pro Gly Ile Val Thr Val Lys Gly Met Ala Asp Gly Arg Glu Val 
        995                 1000                1005            

Glu Ala Arg Val Glu Val Ile Ala Leu Lys Ser Glu Leu Pro Val Val 
    1010                1015                1020                

Lys Arg Ile Ala Pro Asn Thr Asp Leu Asn Ser Val Asp Lys Ser Val 
1025                1030                1035                1040

Ser Tyr Val Leu Ile Asp Gly Ser Val Glu Glu Tyr Glu Val Asp Lys 
                1045                1050                1055    

Trp Glu Ile Ala Glu Glu Asp Lys Ala Lys Gly Ser Gly Ser Gly Gly 
            1060                1065                1070        

Gly Gly Ala Asp Gly Val Thr Pro Thr Thr Thr Glu Asn Gln Pro Thr 
        1075                1080                1085            

Ile His Thr Val Ser Asp Ser Pro Gln Ser Ser Glu Asn Arg Thr Glu 
    1090                1095                1100                

Glu Thr Pro Lys Ala Val Leu Gln Pro Glu Ala Pro Lys Thr Val Glu 
1105                1110                1115                1120

Thr Glu Thr Pro Ala Thr Asp Lys Val Ala Ser Leu Pro Lys Thr Glu 
                1125                1130                1135    

Glu Lys Pro Gln Glu Glu Val Ser Ser Thr Pro Ser Asp Lys Ala Glu 
            1140                1145                1150        

Val Val Thr Pro Thr Ser Ala Glu Lys Glu Thr Ala Asn Lys Lys Ala 
        1155                1160                1165            

Glu Glu Ala Ser Pro Lys Lys Glu Glu Ala Lys Glu Val Asp Ser Lys 
    1170                1175                1180                

Glu Ser Asn Thr Asp Lys Thr Asp Lys Asp Lys Pro Ala Lys Lys Asp 
1185                1190                1195                1200

Glu Ala Lys Ala Glu Ala Asp Lys Pro Ala Thr Glu Ala Gly Lys Glu 
                1205                1210                1215    

Arg Ala Ala Thr Val Asn Glu Lys Leu Ala Lys Lys Lys Ile Val Ser 
            1220                1225                1230        

Ile Asp Ala Gly Arg Lys Tyr Phe Ser Pro Glu Gln Leu Lys Glu Ile 
        1235                1240                1245            

Ile Asp Lys Ala Lys His Tyr Gly Tyr Thr Asp Leu His Leu Leu Val 
    1250                1255                1260                

Gly Asn Asp Gly Leu Arg Phe Met Leu Asp Asp Met Ser Ile Thr Ala 
1265                1270                1275                1280

Asn Gly Lys Thr Tyr Ala Ser Asp Asp Val Lys Arg Ala Ile Glu Lys 
                1285                1290                1295    

Gly Thr Asn Asp Tyr Tyr Asn Asp Pro Asn Gly Asn His Leu Thr Glu 
            1300                1305                1310        

Ser Gln Met Thr Asp Leu Ile Asn Tyr Ala Lys Asp Lys Gly Ile Gly 
        1315                1320                1325            

Leu Ile Pro Thr Val Asn Ser Pro Gly His Met Asp Ala Ile Leu Asn 
    1330                1335                1340                

Ala Met Lys Glu Leu Gly Ile Gln Asn Pro Asn Phe Ser Tyr Phe Gly 
1345                1350                1355                1360

Lys Lys Ser Ala Arg Thr Val Asp Leu Asp Asn Glu Gln Ala Val Ala 
                1365                1370                1375    

Phe Thr Lys Ala Leu Ile Asp Lys Tyr Ala Ala Tyr Phe Ala Lys Lys 
            1380                1385                1390        

Thr Glu Ile Phe Asn Ile Gly Leu Asp Glu Tyr Ala Asn Asp Ala Thr 
        1395                1400                1405            

Asp Ala Lys Gly Trp Ser Val Leu Gln Ala Asp Lys Tyr Tyr Pro Asn 
    1410                1415                1420                

Glu Gly Tyr Pro Val Lys Gly Tyr Glu Lys Phe Ile Ala Tyr Ala Asn 
1425                1430                1435                1440

Asp Leu Ala Arg Ile Val Lys Ser His Gly Leu Lys Pro Met Ala Phe 
                1445                1450                1455    

Asn Asp Gly Ile Tyr Tyr Asn Ser Asp Thr Ser Phe Gly Ser Phe Asp 
            1460                1465                1470        

Lys Asp Ile Ile Val Ser Met Trp Thr Gly Gly Trp Gly Gly Tyr Asp 
        1475                1480                1485            

Val Ala Ser Ser Lys Leu Leu Ala Glu Lys Gly His Gln Ile Leu Asn 
    1490                1495                1500                

Thr Asn Asp Ala Trp Tyr Tyr Val Leu Gly Arg Asn Ala Asp Gly Gln 
1505                1510                1515                1520

Gly Trp Tyr Asn Leu Asp Gln Gly Leu Asn Gly Ile Lys Asn Thr Pro 
                1525                1530                1535    

Ile Thr Ser Val Pro Lys Thr Glu Gly Ala Asp Ile Pro Ile Ile Gly 
            1540                1545                1550        

Gly Met Val Ala Ala Trp Ala Asp Thr Pro Ser Ala Arg Tyr Ser Pro 
        1555                1560                1565            

Ser Arg Leu Phe Lys Leu Met Arg His Phe Ala Asn Ala Asn Ala Glu 
    1570                1575                1580                

Tyr Phe Ala Ala Asp Tyr Glu Ser Ala Glu Gln Ala Leu Asn Glu Val 
1585                1590                1595                1600

Pro Lys Asp Leu Asn Arg Tyr Thr Ala Glu Ser Val Thr Ala Val Lys 
                1605                1610                1615    

Glu Ala Glu Lys Ala Ile Arg Ser Leu Asp Ser Asn Leu Ser Arg Ala 
            1620                1625                1630        

Gln Gln Asp Thr Ile Asp Gln Ala Ile Ala Lys Leu Gln Glu Thr Val 
        1635                1640                1645            

Asn Asn Leu Thr Leu Thr Pro Glu Ala Gln Lys Glu Glu Glu Ala Lys 
    1650                1655                1660                

Arg Glu Val Glu Lys Leu Ala Lys Asn Lys Val Ile Ser Ile Asp Ala 
1665                1670                1675                1680

Gly Arg Lys Tyr Phe Thr Leu Asn Gln Leu Lys Arg Ile Val Asp Lys 
                1685                1690                1695    

Ala Ser Glu Leu Gly Tyr Ser Asp Val His Leu Leu Leu Gly Asn Asp 
            1700                1705                1710        

Gly Leu Arg Phe Leu Leu Asp Asp Met Thr Ile Thr Ala Asn Gly Lys 
        1715                1720                1725            

Thr Tyr Ala Ser Asp Asp Val Lys Lys Ala Ile Ile Glu Gly Thr Lys 
    1730                1735                1740                

Ala Tyr Tyr Asp Asp Pro Asn Gly Thr Ala Leu Thr Gln Ala Glu Val 
1745                1750                1755                1760

Thr Glu Leu Ile Glu Tyr Ala Lys Ser Lys Asp Ile Gly Leu Ile Pro 
                1765                1770                1775    

Ala Ile Asn Ser Pro Gly His Met Asp Ala Met Leu Val Ala Met Glu 
            1780                1785                1790        

Lys Leu Gly Ile Lys Asn Pro Gln Ala His Phe Asp Lys Val Ser Lys 
        1795                1800                1805            

Thr Thr Met Asp Leu Lys Asn Glu Glu Ala Met Asn Phe Val Lys Ala 
    1810                1815                1820                

Leu Ile Gly Lys Tyr Met Asp Phe Phe Ala Gly Lys Thr Lys Ile Phe 
1825                1830                1835                1840

Asn Phe Gly Thr Asp Glu Tyr Ala Asn Asp Ala Thr Ser Ala Gln Gly 
                1845                1850                1855    

Trp Tyr Tyr Leu Lys Trp Tyr Gln Leu Tyr Gly Lys Phe Ala Glu Tyr 
            1860                1865                1870        

Ala Asn Thr Leu Ala Ala Met Ala Lys Glu Arg Gly Leu Gln Pro Met 
        1875                1880                1885            

Ala Phe Asn Asp Gly Phe Tyr Tyr Glu Asp Lys Asp Asp Val Gln Phe 
    1890                1895                1900                

Asp Lys Asp Val Leu Ile Ser Tyr Trp Ser Lys Gly Trp Trp Gly Tyr 
1905                1910                1915                1920

Asn Leu Ala Ser Pro Gln Tyr Leu Ala Ser Lys Gly Tyr Lys Phe Leu 
                1925                1930                1935    

Asn Thr Asn Gly Asp Trp Tyr Tyr Ile Leu Gly Gln Lys Pro Glu Asp 
            1940                1945                1950        

Gly Gly Gly Phe Leu Lys Lys Ala Ile Glu Asn Thr Gly Lys Thr Pro 
        1955                1960                1965            

Phe Asn Gln Leu Ala Ser Thr Lys Tyr Pro Glu Val Asp Leu Pro Thr 
    1970                1975                1980                

Val Gly Ser Met Leu Ser Ile Trp Ala Asp Arg Pro Ser Ala Glu Tyr 
1985                1990                1995                2000

Lys Glu Glu Glu Ile Phe Glu Leu Met Thr Ala Phe Ala Asp His Asn 
                2005                2010                2015    

Lys Asp Tyr Phe Arg Ala Asn Tyr Asn Ala Leu Arg Glu Glu Leu Ala 
            2020                2025                2030        

Lys Ile Pro Thr Asn Leu Glu Gly Tyr Ser Lys Glu Ser Leu Glu Ala 
        2035                2040                2045            

Leu Asp Ala Ala Lys Thr Ala Leu Asn Tyr Asn Leu Asn Arg Asn Lys 
    2050                2055                2060                

Gln Ala Glu Leu Asp Thr Leu Val Ala Asn Leu Lys Ala Ala Leu Gln 
2065                2070                2075                2080

Gly Leu Lys Pro Ala Val Thr His Ser Gly Ser Leu Asp Glu Asn Glu 
                2085                2090                2095    

Val Ala Ala Asn Val Glu Thr Arg Pro Glu Leu Ile Thr Arg Thr Glu 
            2100                2105                2110        

Glu Ile Pro Phe Glu Val Ile Lys Lys Glu Asn Pro Asn Leu Pro Ala 
        2115                2120                2125            

Gly Gln Glu Asn Ile Ile Thr Ala Gly Val Lys Gly Glu Arg Thr His 
    2130                2135                2140                

Tyr Ile Ser Val Leu Thr Glu Asn Gly Lys Thr Thr Glu Thr Val Leu 
2145                2150                2155                2160

Asp Ser Gln Val Thr Lys Glu Val Ile Asn Gln Val Val Glu Val Gly 
                2165                2170                2175    

Ala Pro Val Thr His Lys Gly Asp Glu Ser Gly Leu Ala Pro Thr Thr 
            2180                2185                2190        

Glu Val Lys Pro Arg Leu Asp Ile Gln Glu Glu Glu Ile Pro Phe Thr 
        2195                2200                2205            

Thr Val Thr Cys Glu Asn Pro Leu Leu Leu Lys Gly Lys Thr Gln Val 
    2210                2215                2220                

Ile Thr Lys Gly Val Asn Gly His Arg Ser Asn Phe Tyr Ser Val Ser 
2225                2230                2235                2240

Thr Ser Ala Asp Gly Lys Glu Val Lys Thr Leu Val Asn Ser Val Val 
                2245                2250                2255    

Ala Gln Glu Ala Val Thr Gln Ile Val Glu Val Gly Thr Met Val Thr 
            2260                2265                2270        

His Val Gly Asp Glu Asn Gly Gln Ala Ala Ile Ala Glu Glu Lys Pro 
        2275                2280                2285            

Lys Leu Glu Ile Pro Ser Gln Pro Ala Pro Ser Thr Ala Pro Ala Glu 
    2290                2295                2300                

Glu Ser Lys Val Leu Pro Gln Asp Pro Ala Pro Val Val Thr Glu Lys 
2305                2310                2315                2320

Lys Ala Ala Ala Leu Glu His His His His His His 
                2325                2330        

<210>   219
<211>   2364
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Hybrid polypeptide

<400>   219
Met Ala Ser Ile Ala Glu Glu Asp Lys Ala Lys Leu Ala Ile Pro Gly 
1               5                   10                  15      

Ser Arg Ile Gln Ala Thr Gly Tyr Leu Glu Gly Gln Pro Ile His Ala 
            20                  25                  30          

Thr Leu Val Val Glu Glu Gly Asn Pro Ala Ala Pro Ala Val Pro Thr 
        35                  40                  45              

Val Thr Val Gly Gly Glu Ala Val Thr Gly Leu Thr Ser Gln Lys Pro 
    50                  55                  60                  

Met Gln Tyr Arg Thr Leu Ala Tyr Gly Ala Lys Leu Pro Glu Val Thr 
65                  70                  75                  80  

Ala Ser Ala Lys Asn Ala Ala Val Thr Val Leu Gln Ala Ser Ala Ala 
                85                  90                  95      

Asn Gly Met Arg Ala Ser Ile Phe Ile Gln Pro Lys Asp Gly Gly Pro 
            100                 105                 110         

Leu Gln Thr Tyr Ala Ile Gln Phe Leu Glu Glu Ala Pro Lys Ile Ala 
        115                 120                 125             

His Leu Ser Leu Gln Val Glu Lys Ala Asp Ser Leu Lys Glu Asp Gln 
    130                 135                 140                 

Thr Val Lys Leu Ser Val Arg Ala His Tyr Gln Asp Gly Thr Gln Ala 
145                 150                 155                 160 

Val Leu Pro Ala Asp Lys Val Thr Phe Ser Thr Ser Gly Glu Gly Glu 
                165                 170                 175     

Val Ala Ile Arg Lys Gly Met Leu Glu Leu His Lys Pro Gly Ala Val 
            180                 185                 190         

Thr Leu Asn Ala Glu Tyr Glu Gly Ala Lys Asp Gln Val Glu Leu Thr 
        195                 200                 205             

Ile Gln Ala Asn Thr Glu Lys Lys Ile Ala Gln Ser Ile Arg Pro Val 
    210                 215                 220                 

Asn Val Val Thr Asp Leu His Gln Glu Pro Ser Leu Pro Ala Thr Val 
225                 230                 235                 240 

Thr Val Glu Tyr Asp Lys Gly Phe Pro Lys Thr His Lys Val Thr Trp 
                245                 250                 255     

Gln Ala Ile Pro Lys Glu Lys Leu Asp Ser Tyr Gln Thr Phe Glu Val 
            260                 265                 270         

Leu Gly Lys Val Glu Gly Ile Asp Leu Glu Ala Arg Ala Lys Val Ser 
        275                 280                 285             

Val Glu Gly Ile Val Ser Val Glu Glu Val Ser Val Thr Thr Pro Ile 
    290                 295                 300                 

Ala Glu Ala Pro Gln Leu Pro Glu Ser Val Arg Thr Tyr Asp Ser Asn 
305                 310                 315                 320 

Gly His Val Ser Ser Ala Lys Val Ala Trp Asp Ala Ile Arg Pro Glu 
                325                 330                 335     

Gln Tyr Ala Lys Glu Gly Val Phe Thr Val Asn Gly Arg Leu Glu Gly 
            340                 345                 350         

Thr Gln Leu Thr Thr Lys Leu His Val Arg Val Ser Ala Gln Thr Glu 
        355                 360                 365             

Gln Gly Ala Asn Ile Ser Asp Gln Trp Thr Gly Ser Glu Leu Pro Leu 
    370                 375                 380                 

Ala Phe Ala Ser Asp Ser Asn Pro Ser Asp Pro Val Ser Asn Val Asn 
385                 390                 395                 400 

Asp Lys Leu Ile Ser Tyr Asn Asn Gln Pro Ala Asn Arg Trp Thr Asn 
                405                 410                 415     

Trp Asn Arg Thr Asn Pro Glu Ala Ser Val Gly Val Leu Phe Gly Asp 
            420                 425                 430         

Ser Gly Ile Leu Ser Lys Arg Ser Val Asp Asn Leu Ser Val Gly Phe 
        435                 440                 445             

His Glu Asp His Gly Val Gly Val Pro Lys Ser Tyr Val Ile Glu Tyr 
    450                 455                 460                 

Tyr Val Gly Lys Thr Val Pro Thr Ala Pro Lys Asn Pro Ser Phe Val 
465                 470                 475                 480 

Gly Asn Glu Asp His Val Phe Asn Asp Ser Ala Asn Trp Lys Pro Val 
                485                 490                 495     

Thr Asn Leu Lys Ala Pro Ala Gln Leu Lys Ala Gly Glu Met Asn His 
            500                 505                 510         

Phe Ser Phe Asp Lys Val Glu Thr Tyr Ala Val Arg Ile Arg Met Val 
        515                 520                 525             

Lys Ala Asp Asn Lys Arg Gly Thr Ser Ile Thr Glu Val Gln Ile Phe 
    530                 535                 540                 

Ala Lys Gln Val Ala Ala Ala Lys Gln Gly Gln Thr Arg Ile Gln Val 
545                 550                 555                 560 

Asp Gly Lys Asp Leu Ala Asn Phe Asn Pro Asp Leu Thr Asp Tyr Tyr 
                565                 570                 575     

Leu Glu Ser Val Asp Gly Lys Val Pro Ala Val Thr Ala Ser Val Ser 
            580                 585                 590         

Asn Asn Gly Leu Ala Thr Val Val Pro Ser Val Arg Glu Gly Glu Pro 
        595                 600                 605             

Val Arg Val Ile Ala Lys Ala Glu Asn Gly Asp Ile Leu Gly Glu Tyr 
    610                 615                 620                 

Arg Leu His Phe Thr Lys Asp Lys Ser Leu Leu Ser His Lys Pro Val 
625                 630                 635                 640 

Ala Ala Val Lys Gln Ala Arg Leu Leu Gln Val Gly Gln Ala Leu Glu 
                645                 650                 655     

Leu Pro Thr Lys Val Pro Val Tyr Phe Thr Gly Lys Asp Gly Tyr Glu 
            660                 665                 670         

Thr Lys Asp Leu Thr Val Glu Trp Glu Glu Val Pro Ala Glu Asn Leu 
        675                 680                 685             

Thr Lys Ala Gly Gln Phe Thr Val Arg Gly Arg Val Leu Gly Ser Asn 
    690                 695                 700                 

Leu Val Ala Glu Ile Thr Val Arg Val Thr Asp Lys Leu Gly Glu Thr 
705                 710                 715                 720 

Leu Ser Asp Asn Pro Asn Tyr Asp Glu Asn Ser Asn Gln Ala Phe Ala 
                725                 730                 735     

Ser Ala Thr Asn Asp Ile Asp Lys Asn Ser His Asp Arg Val Asp Tyr 
            740                 745                 750         

Leu Asn Asp Gly Asp His Ser Glu Asn Arg Arg Trp Thr Asn Trp Ser 
        755                 760                 765             

Pro Thr Pro Ser Ser Asn Pro Glu Val Ser Ala Gly Val Ile Phe Arg 
    770                 775                 780                 

Glu Asn Gly Lys Ile Val Glu Arg Thr Val Thr Gln Gly Lys Val Gln 
785                 790                 795                 800 

Phe Phe Ala Asp Ser Gly Thr Asp Ala Pro Ser Lys Leu Val Leu Glu 
                805                 810                 815     

Arg Tyr Val Gly Pro Glu Phe Glu Val Pro Thr Tyr Tyr Ser Asn Tyr 
            820                 825                 830         

Gln Ala Tyr Asp Ala Asp His Pro Phe Asn Asn Pro Glu Asn Trp Glu 
        835                 840                 845             

Ala Val Pro Tyr Arg Ala Asp Lys Asp Ile Ala Ala Gly Asp Glu Ile 
    850                 855                 860                 

Asn Val Thr Phe Lys Ala Ile Lys Ala Lys Ala Met Arg Trp Arg Met 
865                 870                 875                 880 

Glu Arg Lys Ala Asp Lys Ser Gly Val Ala Met Ile Glu Met Thr Phe 
                885                 890                 895     

Leu Ala Pro Ser Glu Leu Pro Gln Glu Ser Thr Gln Ser Lys Ile Leu 
            900                 905                 910         

Val Asp Gly Lys Glu Leu Ala Asp Phe Ala Glu Asn Arg Gln Asp Tyr 
        915                 920                 925             

Gln Ile Thr Tyr Lys Gly Gln Arg Pro Lys Val Ser Val Glu Glu Asn 
    930                 935                 940                 

Asn Gln Val Ala Ser Thr Val Val Asp Ser Gly Glu Asp Ser Phe Pro 
945                 950                 955                 960 

Val Leu Val Arg Leu Val Ser Glu Ser Gly Lys Gln Val Lys Glu Tyr 
                965                 970                 975     

Arg Ile His Leu Thr Lys Glu Lys Pro Val Ser Glu Lys Thr Val Ala 
            980                 985                 990         

Ala Val Gln Glu Asp Leu Pro Lys Ile Glu Phe Val Glu Lys Asp Leu 
        995                 1000                1005            

Ala Tyr Lys Thr Val Glu Lys Lys Asp Ser Thr Leu Tyr Leu Gly Glu 
    1010                1015                1020                

Thr Arg Val Glu Gln Glu Gly Lys Val Gly Lys Glu Arg Ile Phe Thr 
1025                1030                1035                1040

Ala Ile Asn Pro Asp Gly Ser Lys Glu Glu Lys Leu Arg Glu Val Val 
                1045                1050                1055    

Glu Val Pro Thr Asp Arg Ile Val Leu Val Gly Thr Lys Pro Val Ala 
            1060                1065                1070        

Gln Glu Ala Lys Lys Pro Gln Val Ser Glu Lys Ala Asp Thr Lys Pro 
        1075                1080                1085            

Ile Asp Ser Ser Glu Ala Ser Gln Thr Asn Lys Ala Gln Gly Ser Gly 
    1090                1095                1100                

Ser Gly Gly Gly Gly Ala Asp Gly Val Thr Pro Thr Thr Thr Glu Asn 
1105                1110                1115                1120

Gln Pro Thr Ile His Thr Val Ser Asp Ser Pro Gln Ser Ser Glu Asn 
                1125                1130                1135    

Arg Thr Glu Glu Thr Pro Lys Ala Val Leu Gln Pro Glu Ala Pro Lys 
            1140                1145                1150        

Thr Val Glu Thr Glu Thr Pro Ala Thr Asp Lys Val Ala Ser Leu Pro 
        1155                1160                1165            

Lys Thr Glu Glu Lys Pro Gln Glu Glu Val Ser Ser Thr Pro Ser Asp 
    1170                1175                1180                

Lys Ala Glu Val Val Thr Pro Thr Ser Ala Glu Lys Glu Thr Ala Asn 
1185                1190                1195                1200

Lys Lys Ala Glu Glu Ala Ser Pro Lys Lys Glu Glu Ala Lys Glu Val 
                1205                1210                1215    

Asp Ser Lys Glu Ser Asn Thr Asp Lys Thr Asp Lys Asp Lys Pro Ala 
            1220                1225                1230        

Lys Lys Asp Glu Ala Lys Ala Glu Ala Asp Lys Pro Ala Thr Glu Ala 
        1235                1240                1245            

Gly Lys Glu Arg Ala Ala Thr Val Asn Glu Lys Leu Ala Lys Lys Lys 
    1250                1255                1260                

Ile Val Ser Ile Asp Ala Gly Arg Lys Tyr Phe Ser Pro Glu Gln Leu 
1265                1270                1275                1280

Lys Glu Ile Ile Asp Lys Ala Lys His Tyr Gly Tyr Thr Asp Leu His 
                1285                1290                1295    

Leu Leu Val Gly Asn Asp Gly Leu Arg Phe Met Leu Asp Asp Met Ser 
            1300                1305                1310        

Ile Thr Ala Asn Gly Lys Thr Tyr Ala Ser Asp Asp Val Lys Arg Ala 
        1315                1320                1325            

Ile Glu Lys Gly Thr Asn Asp Tyr Tyr Asn Asp Pro Asn Gly Asn His 
    1330                1335                1340                

Leu Thr Glu Ser Gln Met Thr Asp Leu Ile Asn Tyr Ala Lys Asp Lys 
1345                1350                1355                1360

Gly Ile Gly Leu Ile Pro Thr Val Asn Ser Pro Gly His Met Asp Ala 
                1365                1370                1375    

Ile Leu Asn Ala Met Lys Glu Leu Gly Ile Gln Asn Pro Asn Phe Ser 
            1380                1385                1390        

Tyr Phe Gly Lys Lys Ser Ala Arg Thr Val Asp Leu Asp Asn Glu Gln 
        1395                1400                1405            

Ala Val Ala Phe Thr Lys Ala Leu Ile Asp Lys Tyr Ala Ala Tyr Phe 
    1410                1415                1420                

Ala Lys Lys Thr Glu Ile Phe Asn Ile Gly Leu Asp Glu Tyr Ala Asn 
1425                1430                1435                1440

Asp Ala Thr Asp Ala Lys Gly Trp Ser Val Leu Gln Ala Asp Lys Tyr 
                1445                1450                1455    

Tyr Pro Asn Glu Gly Tyr Pro Val Lys Gly Tyr Glu Lys Phe Ile Ala 
            1460                1465                1470        

Tyr Ala Asn Asp Leu Ala Arg Ile Val Lys Ser His Gly Leu Lys Pro 
        1475                1480                1485            

Met Ala Phe Asn Asp Gly Ile Tyr Tyr Asn Ser Asp Thr Ser Phe Gly 
    1490                1495                1500                

Ser Phe Asp Lys Asp Ile Ile Val Ser Met Trp Thr Gly Gly Trp Gly 
1505                1510                1515                1520

Gly Tyr Asp Val Ala Ser Ser Lys Leu Leu Ala Glu Lys Gly His Gln 
                1525                1530                1535    

Ile Leu Asn Thr Asn Asp Ala Trp Tyr Tyr Val Leu Gly Arg Asn Ala 
            1540                1545                1550        

Asp Gly Gln Gly Trp Tyr Asn Leu Asp Gln Gly Leu Asn Gly Ile Lys 
        1555                1560                1565            

Asn Thr Pro Ile Thr Ser Val Pro Lys Thr Glu Gly Ala Asp Ile Pro 
    1570                1575                1580                

Ile Ile Gly Gly Met Val Ala Ala Trp Ala Asp Thr Pro Ser Ala Arg 
1585                1590                1595                1600

Tyr Ser Pro Ser Arg Leu Phe Lys Leu Met Arg His Phe Ala Asn Ala 
                1605                1610                1615    

Asn Ala Glu Tyr Phe Ala Ala Asp Tyr Glu Ser Ala Glu Gln Ala Leu 
            1620                1625                1630        

Asn Glu Val Pro Lys Asp Leu Asn Arg Tyr Thr Ala Glu Ser Val Thr 
        1635                1640                1645            

Ala Val Lys Glu Ala Glu Lys Ala Ile Arg Ser Leu Asp Ser Asn Leu 
    1650                1655                1660                

Ser Arg Ala Gln Gln Asp Thr Ile Asp Gln Ala Ile Ala Lys Leu Gln 
1665                1670                1675                1680

Glu Thr Val Asn Asn Leu Thr Leu Thr Pro Glu Ala Gln Lys Glu Glu 
                1685                1690                1695    

Glu Ala Lys Arg Glu Val Glu Lys Leu Ala Lys Asn Lys Val Ile Ser 
            1700                1705                1710        

Ile Asp Ala Gly Arg Lys Tyr Phe Thr Leu Asn Gln Leu Lys Arg Ile 
        1715                1720                1725            

Val Asp Lys Ala Ser Glu Leu Gly Tyr Ser Asp Val His Leu Leu Leu 
    1730                1735                1740                

Gly Asn Asp Gly Leu Arg Phe Leu Leu Asp Asp Met Thr Ile Thr Ala 
1745                1750                1755                1760

Asn Gly Lys Thr Tyr Ala Ser Asp Asp Val Lys Lys Ala Ile Ile Glu 
                1765                1770                1775    

Gly Thr Lys Ala Tyr Tyr Asp Asp Pro Asn Gly Thr Ala Leu Thr Gln 
            1780                1785                1790        

Ala Glu Val Thr Glu Leu Ile Glu Tyr Ala Lys Ser Lys Asp Ile Gly 
        1795                1800                1805            

Leu Ile Pro Ala Ile Asn Ser Pro Gly His Met Asp Ala Met Leu Val 
    1810                1815                1820                

Ala Met Glu Lys Leu Gly Ile Lys Asn Pro Gln Ala His Phe Asp Lys 
1825                1830                1835                1840

Val Ser Lys Thr Thr Met Asp Leu Lys Asn Glu Glu Ala Met Asn Phe 
                1845                1850                1855    

Val Lys Ala Leu Ile Gly Lys Tyr Met Asp Phe Phe Ala Gly Lys Thr 
            1860                1865                1870        

Lys Ile Phe Asn Phe Gly Thr Asp Glu Tyr Ala Asn Asp Ala Thr Ser 
        1875                1880                1885            

Ala Gln Gly Trp Tyr Tyr Leu Lys Trp Tyr Gln Leu Tyr Gly Lys Phe 
    1890                1895                1900                

Ala Glu Tyr Ala Asn Thr Leu Ala Ala Met Ala Lys Glu Arg Gly Leu 
1905                1910                1915                1920

Gln Pro Met Ala Phe Asn Asp Gly Phe Tyr Tyr Glu Asp Lys Asp Asp 
                1925                1930                1935    

Val Gln Phe Asp Lys Asp Val Leu Ile Ser Tyr Trp Ser Lys Gly Trp 
            1940                1945                1950        

Trp Gly Tyr Asn Leu Ala Ser Pro Gln Tyr Leu Ala Ser Lys Gly Tyr 
        1955                1960                1965            

Lys Phe Leu Asn Thr Asn Gly Asp Trp Tyr Tyr Ile Leu Gly Gln Lys 
    1970                1975                1980                

Pro Glu Asp Gly Gly Gly Phe Leu Lys Lys Ala Ile Glu Asn Thr Gly 
1985                1990                1995                2000

Lys Thr Pro Phe Asn Gln Leu Ala Ser Thr Lys Tyr Pro Glu Val Asp 
                2005                2010                2015    

Leu Pro Thr Val Gly Ser Met Leu Ser Ile Trp Ala Asp Arg Pro Ser 
            2020                2025                2030        

Ala Glu Tyr Lys Glu Glu Glu Ile Phe Glu Leu Met Thr Ala Phe Ala 
        2035                2040                2045            

Asp His Asn Lys Asp Tyr Phe Arg Ala Asn Tyr Asn Ala Leu Arg Glu 
    2050                2055                2060                

Glu Leu Ala Lys Ile Pro Thr Asn Leu Glu Gly Tyr Ser Lys Glu Ser 
2065                2070                2075                2080

Leu Glu Ala Leu Asp Ala Ala Lys Thr Ala Leu Asn Tyr Asn Leu Asn 
                2085                2090                2095    

Arg Asn Lys Gln Ala Glu Leu Asp Thr Leu Val Ala Asn Leu Lys Ala 
            2100                2105                2110        

Ala Leu Gln Gly Leu Lys Pro Ala Val Thr His Ser Gly Ser Leu Asp 
        2115                2120                2125            

Glu Asn Glu Val Ala Ala Asn Val Glu Thr Arg Pro Glu Leu Ile Thr 
    2130                2135                2140                

Arg Thr Glu Glu Ile Pro Phe Glu Val Ile Lys Lys Glu Asn Pro Asn 
2145                2150                2155                2160

Leu Pro Ala Gly Gln Glu Asn Ile Ile Thr Ala Gly Val Lys Gly Glu 
                2165                2170                2175    

Arg Thr His Tyr Ile Ser Val Leu Thr Glu Asn Gly Lys Thr Thr Glu 
            2180                2185                2190        

Thr Val Leu Asp Ser Gln Val Thr Lys Glu Val Ile Asn Gln Val Val 
        2195                2200                2205            

Glu Val Gly Ala Pro Val Thr His Lys Gly Asp Glu Ser Gly Leu Ala 
    2210                2215                2220                

Pro Thr Thr Glu Val Lys Pro Arg Leu Asp Ile Gln Glu Glu Glu Ile 
2225                2230                2235                2240

Pro Phe Thr Thr Val Thr Cys Glu Asn Pro Leu Leu Leu Lys Gly Lys 
                2245                2250                2255    

Thr Gln Val Ile Thr Lys Gly Val Asn Gly His Arg Ser Asn Phe Tyr 
            2260                2265                2270        

Ser Val Ser Thr Ser Ala Asp Gly Lys Glu Val Lys Thr Leu Val Asn 
        2275                2280                2285            

Ser Val Val Ala Gln Glu Ala Val Thr Gln Ile Val Glu Val Gly Thr 
    2290                2295                2300                

Met Val Thr His Val Gly Asp Glu Asn Gly Gln Ala Ala Ile Ala Glu 
2305                2310                2315                2320

Glu Lys Pro Lys Leu Glu Ile Pro Ser Gln Pro Ala Pro Ser Thr Ala 
                2325                2330                2335    

Pro Ala Glu Glu Ser Lys Val Leu Pro Gln Asp Pro Ala Pro Val Val 
            2340                2345                2350        

Thr Glu Lys Lys Leu Glu His His His His His His 
        2355                2360                

<210>   220
<211>   2341
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Hybrid polypeptide

<400>   220
Met Ala Ser Asp Glu Thr Leu Ile Thr His Thr Ala Glu Lys Pro Lys 
1               5                   10                  15      

Glu Glu Lys Met Ile Val Glu Glu Lys Ala Asp Lys Ala Leu Glu Thr 
            20                  25                  30          

Lys Asn Ile Val Glu Arg Thr Glu Gln Ser Glu Pro Ser Ser Thr Glu 
        35                  40                  45              

Ala Ile Ala Ser Glu Lys Lys Glu Asp Glu Ala Val Thr Pro Lys Glu 
    50                  55                  60                  

Glu Lys Val Ser Ala Lys Pro Glu Glu Lys Ala Pro Arg Ile Glu Ser 
65                  70                  75                  80  

Gln Ala Ser Asn Gln Glu Lys Pro Leu Lys Glu Asp Ala Lys Ala Val 
                85                  90                  95      

Thr Asn Glu Glu Val Asn Gln Met Ile Glu Asp Arg Lys Val Asp Phe 
            100                 105                 110         

Asn Gln Asn Trp Tyr Phe Lys Leu Asn Ala Asn Ser Lys Glu Ala Ile 
        115                 120                 125             

Lys Pro Asp Ala Asp Val Ser Thr Trp Lys Lys Leu Asp Leu Pro Tyr 
    130                 135                 140                 

Asp Trp Ser Ile Phe Asn Asp Phe Asp His Glu Ser Pro Ala Gln Asn 
145                 150                 155                 160 

Glu Gly Gly Gln Leu Asn Gly Gly Glu Ala Trp Tyr Arg Lys Thr Phe 
                165                 170                 175     

Lys Leu Asp Glu Lys Asp Leu Lys Lys Asn Val Arg Leu Thr Phe Asp 
            180                 185                 190         

Gly Val Tyr Met Asp Ser Gln Val Tyr Val Asn Gly Gln Leu Val Gly 
        195                 200                 205             

His Tyr Pro Asn Gly Tyr Asn Gln Phe Ser Tyr Asp Ile Thr Lys Tyr 
    210                 215                 220                 

Leu Gln Lys Asp Gly Arg Glu Asn Val Ile Ala Val His Ala Val Asn 
225                 230                 235                 240 

Lys Gln Pro Ser Ser Arg Trp Tyr Ser Gly Ser Gly Ile Tyr Arg Asp 
                245                 250                 255     

Val Thr Leu Gln Val Thr Asp Lys Val His Val Glu Lys Asn Gly Thr 
            260                 265                 270         

Thr Ile Leu Thr Pro Lys Leu Glu Glu Gln Gln His Gly Lys Val Glu 
        275                 280                 285             

Thr His Val Thr Ser Lys Ile Val Asn Thr Asp Asp Lys Asp His Glu 
    290                 295                 300                 

Leu Val Ala Glu Tyr Gln Ile Val Glu Arg Gly Gly His Ala Val Thr 
305                 310                 315                 320 

Gly Leu Val Arg Thr Ala Ser Arg Thr Leu Lys Ala His Glu Ser Thr 
                325                 330                 335     

Ser Leu Asp Ala Ile Leu Glu Val Glu Arg Pro Lys Leu Trp Thr Val 
            340                 345                 350         

Leu Asn Asp Lys Pro Ala Leu Tyr Glu Leu Ile Thr Arg Val Tyr Arg 
        355                 360                 365             

Asp Gly Gln Leu Val Asp Ala Lys Lys Asp Leu Phe Gly Tyr Arg Tyr 
    370                 375                 380                 

Tyr His Trp Thr Pro Asn Glu Gly Phe Ser Leu Asn Gly Glu Arg Ile 
385                 390                 395                 400 

Lys Phe His Gly Val Ser Leu His His Asp His Gly Ala Leu Gly Ala 
                405                 410                 415     

Glu Glu Asn Tyr Lys Ala Glu Tyr Arg Arg Leu Lys Gln Met Lys Glu 
            420                 425                 430         

Met Gly Val Asn Ser Ile Arg Thr Thr His Asn Pro Ala Ser Glu Gln 
        435                 440                 445             

Thr Leu Gln Ile Ala Ala Glu Leu Gly Leu Leu Val Gln Glu Glu Ala 
    450                 455                 460                 

Phe Asp Thr Trp Tyr Gly Gly Lys Lys Pro Tyr Asp Tyr Gly Arg Phe 
465                 470                 475                 480 

Phe Glu Lys Asp Ala Thr His Pro Glu Ala Arg Lys Gly Glu Lys Trp 
                485                 490                 495     

Ser Asp Phe Asp Leu Arg Thr Met Val Glu Arg Gly Lys Asn Asn Pro 
            500                 505                 510         

Ala Ile Phe Met Trp Ser Ile Gly Asn Glu Ile Gly Glu Ala Asn Gly 
        515                 520                 525             

Asp Ala His Ser Leu Ala Thr Val Lys Arg Leu Val Lys Val Ile Lys 
    530                 535                 540                 

Asp Val Asp Lys Thr Arg Tyr Val Thr Met Gly Ala Asp Lys Phe Arg 
545                 550                 555                 560 

Phe Gly Asn Gly Ser Gly Gly His Glu Lys Ile Ala Asp Glu Leu Asp 
                565                 570                 575     

Ala Val Gly Phe Asn Tyr Ser Glu Asp Asn Tyr Lys Ala Leu Arg Ala 
            580                 585                 590         

Lys His Pro Lys Trp Leu Ile Tyr Gly Ser Glu Thr Ser Ser Ala Thr 
        595                 600                 605             

Arg Thr Arg Gly Ser Tyr Tyr Arg Pro Glu Arg Glu Leu Lys His Ser 
    610                 615                 620                 

Asn Gly Pro Glu Arg Asn Tyr Glu Gln Ser Asp Tyr Gly Asn Asp Arg 
625                 630                 635                 640 

Val Gly Trp Gly Lys Thr Ala Thr Ala Ser Trp Thr Phe Asp Arg Asp 
                645                 650                 655     

Asn Ala Gly Tyr Ala Gly Gln Phe Ile Trp Thr Gly Thr Asp Tyr Ile 
            660                 665                 670         

Gly Glu Pro Thr Pro Trp His Asn Gln Asn Gln Thr Pro Val Lys Ser 
        675                 680                 685             

Ser Tyr Phe Gly Ile Val Asp Thr Ala Gly Ile Pro Lys His Asp Phe 
    690                 695                 700                 

Tyr Leu Tyr Gln Ser Gln Trp Val Ser Val Lys Lys Lys Pro Met Val 
705                 710                 715                 720 

His Leu Leu Pro His Trp Asn Trp Glu Asn Lys Glu Leu Ala Ser Lys 
                725                 730                 735     

Val Ala Asp Ser Glu Gly Lys Ile Pro Val Arg Ala Tyr Ser Asn Ala 
            740                 745                 750         

Ser Ser Val Glu Leu Phe Leu Asn Gly Lys Ser Leu Gly Leu Lys Thr 
        755                 760                 765             

Phe Asn Lys Lys Gln Thr Ser Asp Gly Arg Thr Tyr Gln Glu Gly Ala 
    770                 775                 780                 

Asn Ala Asn Glu Leu Tyr Leu Glu Trp Lys Val Ala Tyr Gln Pro Gly 
785                 790                 795                 800 

Thr Leu Glu Ala Ile Ala Arg Asp Glu Ser Gly Lys Glu Ile Ala Arg 
                805                 810                 815     

Asp Lys Ile Thr Thr Ala Gly Lys Pro Ala Ala Val Arg Leu Ile Lys 
            820                 825                 830         

Glu Asp His Ala Ile Ala Ala Asp Gly Lys Asp Leu Thr Tyr Ile Tyr 
        835                 840                 845             

Tyr Glu Ile Val Asp Ser Gln Gly Asn Val Val Pro Thr Ala Asn Asn 
    850                 855                 860                 

Leu Val Arg Phe Gln Leu His Gly Gln Gly Gln Leu Val Gly Val Asp 
865                 870                 875                 880 

Asn Gly Glu Gln Ala Ser Arg Glu Arg Tyr Lys Ala Gln Ala Asp Gly 
                885                 890                 895     

Ser Trp Ile Arg Lys Ala Phe Asn Gly Lys Gly Val Ala Ile Val Lys 
            900                 905                 910         

Ser Thr Glu Gln Ala Gly Lys Phe Thr Leu Thr Ala His Ser Asp Leu 
        915                 920                 925             

Leu Lys Ser Asn Gln Val Thr Val Phe Thr Gly Lys Lys Glu Gly Gln 
    930                 935                 940                 

Glu Lys Thr Val Leu Gly Thr Glu Val Pro Lys Val Gln Thr Ile Ile 
945                 950                 955                 960 

Gly Glu Ala Pro Glu Met Pro Thr Thr Val Pro Phe Val Tyr Ser Asp 
                965                 970                 975     

Gly Ser Arg Ala Glu Arg Pro Val Thr Trp Ser Ser Val Asp Val Ser 
            980                 985                 990         

Lys Pro Gly Ile Val Thr Val Lys Gly Met Ala Asp Gly Arg Glu Val 
        995                 1000                1005            

Glu Ala Arg Val Glu Val Ile Ala Leu Lys Ser Glu Leu Pro Val Val 
    1010                1015                1020                

Lys Arg Ile Ala Pro Asn Thr Asp Leu Asn Ser Val Asp Lys Ser Val 
1025                1030                1035                1040

Ser Tyr Val Leu Ile Asp Gly Ser Val Glu Glu Tyr Glu Val Asp Lys 
                1045                1050                1055    

Trp Glu Ile Ala Glu Glu Asp Lys Ala Lys Leu Ala Ile Pro Gly Ser 
            1060                1065                1070        

Arg Ile Gln Ala Thr Gly Tyr Leu Glu Gly Gln Pro Ile His Ala Thr 
        1075                1080                1085            

Leu Val Val Glu Glu Gly Asn Pro Ala Ala Pro Ala Val Pro Thr Val 
    1090                1095                1100                

Thr Val Gly Gly Glu Ala Val Thr Gly Leu Thr Ser Gln Lys Pro Met 
1105                1110                1115                1120

Gln Tyr Arg Thr Leu Ala Tyr Gly Ala Lys Leu Pro Glu Val Thr Ala 
                1125                1130                1135    

Ser Ala Lys Asn Ala Ala Val Thr Val Leu Gln Ala Ser Ala Ala Asn 
            1140                1145                1150        

Gly Met Arg Ala Ser Ile Phe Ile Gln Pro Lys Asp Gly Gly Pro Leu 
        1155                1160                1165            

Gln Thr Tyr Ala Ile Gln Phe Leu Glu Glu Ala Pro Lys Ile Ala His 
    1170                1175                1180                

Leu Ser Leu Gln Val Glu Lys Ala Asp Ser Leu Lys Glu Asp Gln Thr 
1185                1190                1195                1200

Val Lys Leu Ser Val Arg Ala His Tyr Gln Asp Gly Thr Gln Ala Val 
                1205                1210                1215    

Leu Pro Ala Asp Lys Val Thr Phe Ser Thr Ser Gly Glu Gly Glu Val 
            1220                1225                1230        

Ala Ile Arg Lys Gly Met Leu Glu Leu His Lys Pro Gly Ala Val Thr 
        1235                1240                1245            

Leu Asn Ala Glu Tyr Glu Gly Ala Lys Asp Gln Val Glu Leu Thr Ile 
    1250                1255                1260                

Gln Ala Asn Thr Glu Lys Lys Ile Ala Gln Ser Ile Arg Pro Val Asn 
1265                1270                1275                1280

Val Val Thr Asp Leu His Gln Glu Pro Ser Leu Pro Ala Thr Val Thr 
                1285                1290                1295    

Val Glu Tyr Asp Lys Gly Phe Pro Lys Thr His Lys Val Thr Trp Gln 
            1300                1305                1310        

Ala Ile Pro Lys Glu Lys Leu Asp Ser Tyr Gln Thr Phe Glu Val Leu 
        1315                1320                1325            

Gly Lys Val Glu Gly Ile Asp Leu Glu Ala Arg Ala Lys Val Ser Val 
    1330                1335                1340                

Glu Gly Ile Val Ser Val Glu Glu Val Ser Val Thr Thr Pro Ile Ala 
1345                1350                1355                1360

Glu Ala Pro Gln Leu Pro Glu Ser Val Arg Thr Tyr Asp Ser Asn Gly 
                1365                1370                1375    

His Val Ser Ser Ala Lys Val Ala Trp Asp Ala Ile Arg Pro Glu Gln 
            1380                1385                1390        

Tyr Ala Lys Glu Gly Val Phe Thr Val Asn Gly Arg Leu Glu Gly Thr 
        1395                1400                1405            

Gln Leu Thr Thr Lys Leu His Val Arg Val Ser Ala Gln Thr Glu Gln 
    1410                1415                1420                

Gly Ala Asn Ile Ser Asp Gln Trp Thr Gly Ser Glu Leu Pro Leu Ala 
1425                1430                1435                1440

Phe Ala Ser Asp Ser Asn Pro Ser Asp Pro Val Ser Asn Val Asn Asp 
                1445                1450                1455    

Lys Leu Ile Ser Tyr Asn Asn Gln Pro Ala Asn Arg Trp Thr Asn Trp 
            1460                1465                1470        

Asn Arg Thr Asn Pro Glu Ala Ser Val Gly Val Leu Phe Gly Asp Ser 
        1475                1480                1485            

Gly Ile Leu Ser Lys Arg Ser Val Asp Asn Leu Ser Val Gly Phe His 
    1490                1495                1500                

Glu Asp His Gly Val Gly Val Pro Lys Ser Tyr Val Ile Glu Tyr Tyr 
1505                1510                1515                1520

Val Gly Lys Thr Val Pro Thr Ala Pro Lys Asn Pro Ser Phe Val Gly 
                1525                1530                1535    

Asn Glu Asp His Val Phe Asn Asp Ser Ala Asn Trp Lys Pro Val Thr 
            1540                1545                1550        

Asn Leu Lys Ala Pro Ala Gln Leu Lys Ala Gly Glu Met Asn His Phe 
        1555                1560                1565            

Ser Phe Asp Lys Val Glu Thr Tyr Ala Val Arg Ile Arg Met Val Lys 
    1570                1575                1580                

Ala Asp Asn Lys Arg Gly Thr Ser Ile Thr Glu Val Gln Ile Phe Ala 
1585                1590                1595                1600

Lys Gln Val Ala Ala Ala Lys Gln Gly Gln Thr Arg Ile Gln Val Asp 
                1605                1610                1615    

Gly Lys Asp Leu Ala Asn Phe Asn Pro Asp Leu Thr Asp Tyr Tyr Leu 
            1620                1625                1630        

Glu Ser Val Asp Gly Lys Val Pro Ala Val Thr Ala Ser Val Ser Asn 
        1635                1640                1645            

Asn Gly Leu Ala Thr Val Val Pro Ser Val Arg Glu Gly Glu Pro Val 
    1650                1655                1660                

Arg Val Ile Ala Lys Ala Glu Asn Gly Asp Ile Leu Gly Glu Tyr Arg 
1665                1670                1675                1680

Leu His Phe Thr Lys Asp Lys Ser Leu Leu Ser His Lys Pro Val Ala 
                1685                1690                1695    

Ala Val Lys Gln Ala Arg Leu Leu Gln Val Gly Gln Ala Leu Glu Leu 
            1700                1705                1710        

Pro Thr Lys Val Pro Val Tyr Phe Thr Gly Lys Asp Gly Tyr Glu Thr 
        1715                1720                1725            

Lys Asp Leu Thr Val Glu Trp Glu Glu Val Pro Ala Glu Asn Leu Thr 
    1730                1735                1740                

Lys Ala Gly Gln Phe Thr Val Arg Gly Arg Val Leu Gly Ser Asn Leu 
1745                1750                1755                1760

Val Ala Glu Ile Thr Val Arg Val Thr Asp Lys Leu Gly Glu Thr Leu 
                1765                1770                1775    

Ser Asp Asn Pro Asn Tyr Asp Glu Asn Ser Asn Gln Ala Phe Ala Ser 
            1780                1785                1790        

Ala Thr Asn Asp Ile Asp Lys Asn Ser His Asp Arg Val Asp Tyr Leu 
        1795                1800                1805            

Asn Asp Gly Asp His Ser Glu Asn Arg Arg Trp Thr Asn Trp Ser Pro 
    1810                1815                1820                

Thr Pro Ser Ser Asn Pro Glu Val Ser Ala Gly Val Ile Phe Arg Glu 
1825                1830                1835                1840

Asn Gly Lys Ile Val Glu Arg Thr Val Thr Gln Gly Lys Val Gln Phe 
                1845                1850                1855    

Phe Ala Asp Ser Gly Thr Asp Ala Pro Ser Lys Leu Val Leu Glu Arg 
            1860                1865                1870        

Tyr Val Gly Pro Glu Phe Glu Val Pro Thr Tyr Tyr Ser Asn Tyr Gln 
        1875                1880                1885            

Ala Tyr Asp Ala Asp His Pro Phe Asn Asn Pro Glu Asn Trp Glu Ala 
    1890                1895                1900                

Val Pro Tyr Arg Ala Asp Lys Asp Ile Ala Ala Gly Asp Glu Ile Asn 
1905                1910                1915                1920

Val Thr Phe Lys Ala Ile Lys Ala Lys Ala Met Arg Trp Arg Met Glu 
                1925                1930                1935    

Arg Lys Ala Asp Lys Ser Gly Val Ala Met Ile Glu Met Thr Phe Leu 
            1940                1945                1950        

Ala Pro Ser Glu Leu Pro Gln Glu Ser Thr Gln Ser Lys Ile Leu Val 
        1955                1960                1965            

Asp Gly Lys Glu Leu Ala Asp Phe Ala Glu Asn Arg Gln Asp Tyr Gln 
    1970                1975                1980                

Ile Thr Tyr Lys Gly Gln Arg Pro Lys Val Ser Val Glu Glu Asn Asn 
1985                1990                1995                2000

Gln Val Ala Ser Thr Val Val Asp Ser Gly Glu Asp Ser Phe Pro Val 
                2005                2010                2015    

Leu Val Arg Leu Val Ser Glu Ser Gly Lys Gln Val Lys Glu Tyr Arg 
            2020                2025                2030        

Ile His Leu Thr Lys Glu Lys Pro Val Ser Glu Lys Thr Val Ala Ala 
        2035                2040                2045            

Val Gln Glu Asp Leu Pro Lys Ile Glu Phe Val Glu Lys Asp Leu Ala 
    2050                2055                2060                

Tyr Lys Thr Val Glu Lys Lys Asp Ser Thr Leu Tyr Leu Gly Glu Thr 
2065                2070                2075                2080

Arg Val Glu Gln Glu Gly Lys Val Gly Lys Glu Arg Ile Phe Thr Ala 
                2085                2090                2095    

Ile Asn Pro Asp Gly Ser Lys Glu Glu Lys Leu Arg Glu Val Val Glu 
            2100                2105                2110        

Val Pro Thr Asp Arg Ile Val Leu Val Gly Thr Lys Pro Val Ala Gln 
        2115                2120                2125            

Glu Ala Lys Lys Pro Gln Val Ser Glu Lys Ala Asp Thr Lys Pro Ile 
    2130                2135                2140                

Asp Ser Ser Glu Ala Ser Gln Thr Asn Lys Ala Gln Gly Ser Gly Ser 
2145                2150                2155                2160

Gly Gly Gly Gly Val Ser Ala Gln Glu Ser Ser Thr Tyr Thr Val Lys 
                2165                2170                2175    

Glu Gly Asp Thr Leu Ser Glu Ile Ala Glu Thr His Asn Thr Thr Val 
            2180                2185                2190        

Glu Lys Leu Ala Glu Asn Asn His Ile Asp Asn Ile His Leu Ile Tyr 
        2195                2200                2205            

Val Asp Gln Glu Leu Val Ile Asp Gly Pro Val Ala Pro Val Ala Thr 
    2210                2215                2220                

Pro Ala Pro Ala Thr Tyr Ala Ala Pro Ala Ala Gln Asp Glu Thr Val 
2225                2230                2235                2240

Ser Ala Pro Val Ala Glu Thr Pro Val Val Ser Glu Thr Val Val Ser 
                2245                2250                2255    

Thr Val Ser Gly Ser Glu Ala Glu Ala Lys Glu Trp Ile Ala Gln Lys 
            2260                2265                2270        

Glu Ser Gly Gly Ser Tyr Thr Ala Thr Asn Gly Arg Tyr Ile Gly Arg 
        2275                2280                2285            

Tyr Gln Leu Thr Asp Ser Tyr Leu Asn Gly Asp Tyr Ser Ala Glu Asn 
    2290                2295                2300                

Gln Glu Arg Val Ala Asp Ala Tyr Val Ala Gly Arg Tyr Gly Ser Trp 
2305                2310                2315                2320

Thr Ala Ala Lys Asn Phe Trp Leu Asn Asn Gly Trp Tyr Leu Glu His 
                2325                2330                2335    

His His His His His 
            2340    

<210>   221
<211>   1251
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Hybrid polypeptide

<400>   221
Met Ala Ser Asp Glu Thr Leu Ile Thr His Thr Ala Glu Lys Pro Lys 
1               5                   10                  15      

Glu Glu Lys Met Ile Val Glu Glu Lys Ala Asp Lys Ala Leu Glu Thr 
            20                  25                  30          

Lys Asn Ile Val Glu Arg Thr Glu Gln Ser Glu Pro Ser Ser Thr Glu 
        35                  40                  45              

Ala Ile Ala Ser Glu Lys Lys Glu Asp Glu Ala Val Thr Pro Lys Glu 
    50                  55                  60                  

Glu Lys Val Ser Ala Lys Pro Glu Glu Lys Ala Pro Arg Ile Glu Ser 
65                  70                  75                  80  

Gln Ala Ser Asn Gln Glu Lys Pro Leu Lys Glu Asp Ala Lys Ala Val 
                85                  90                  95      

Thr Asn Glu Glu Val Asn Gln Met Ile Glu Asp Arg Lys Val Asp Phe 
            100                 105                 110         

Asn Gln Asn Trp Tyr Phe Lys Leu Asn Ala Asn Ser Lys Glu Ala Ile 
        115                 120                 125             

Lys Pro Asp Ala Asp Val Ser Thr Trp Lys Lys Leu Asp Leu Pro Tyr 
    130                 135                 140                 

Asp Trp Ser Ile Phe Asn Asp Phe Asp His Glu Ser Pro Ala Gln Asn 
145                 150                 155                 160 

Glu Gly Gly Gln Leu Asn Gly Gly Glu Ala Trp Tyr Arg Lys Thr Phe 
                165                 170                 175     

Lys Leu Asp Glu Lys Asp Leu Lys Lys Asn Val Arg Leu Thr Phe Asp 
            180                 185                 190         

Gly Val Tyr Met Asp Ser Gln Val Tyr Val Asn Gly Gln Leu Val Gly 
        195                 200                 205             

His Tyr Pro Asn Gly Tyr Asn Gln Phe Ser Tyr Asp Ile Thr Lys Tyr 
    210                 215                 220                 

Leu Gln Lys Asp Gly Arg Glu Asn Val Ile Ala Val His Ala Val Asn 
225                 230                 235                 240 

Lys Gln Pro Ser Ser Arg Trp Tyr Ser Gly Ser Gly Ile Tyr Arg Asp 
                245                 250                 255     

Val Thr Leu Gln Val Thr Asp Lys Val His Val Glu Lys Asn Gly Thr 
            260                 265                 270         

Thr Ile Leu Thr Pro Lys Leu Glu Glu Gln Gln His Gly Lys Val Glu 
        275                 280                 285             

Thr His Val Thr Ser Lys Ile Val Asn Thr Asp Asp Lys Asp His Glu 
    290                 295                 300                 

Leu Val Ala Glu Tyr Gln Ile Val Glu Arg Gly Gly His Ala Val Thr 
305                 310                 315                 320 

Gly Leu Val Arg Thr Ala Ser Arg Thr Leu Lys Ala His Glu Ser Thr 
                325                 330                 335     

Ser Leu Asp Ala Ile Leu Glu Val Glu Arg Pro Lys Leu Trp Thr Val 
            340                 345                 350         

Leu Asn Asp Lys Pro Ala Leu Tyr Glu Leu Ile Thr Arg Val Tyr Arg 
        355                 360                 365             

Asp Gly Gln Leu Val Asp Ala Lys Lys Asp Leu Phe Gly Tyr Arg Tyr 
    370                 375                 380                 

Tyr His Trp Thr Pro Asn Glu Gly Phe Ser Leu Asn Gly Glu Arg Ile 
385                 390                 395                 400 

Lys Phe His Gly Val Ser Leu His His Asp His Gly Ala Leu Gly Ala 
                405                 410                 415     

Glu Glu Asn Tyr Lys Ala Glu Tyr Arg Arg Leu Lys Gln Met Lys Glu 
            420                 425                 430         

Met Gly Val Asn Ser Ile Arg Thr Thr His Asn Pro Ala Ser Glu Gln 
        435                 440                 445             

Thr Leu Gln Ile Ala Ala Glu Leu Gly Leu Leu Val Gln Glu Glu Ala 
    450                 455                 460                 

Phe Asp Thr Trp Tyr Gly Gly Lys Lys Pro Tyr Asp Tyr Gly Arg Phe 
465                 470                 475                 480 

Phe Glu Lys Asp Ala Thr His Pro Glu Ala Arg Lys Gly Glu Lys Trp 
                485                 490                 495     

Ser Asp Phe Asp Leu Arg Thr Met Val Glu Arg Gly Lys Asn Asn Pro 
            500                 505                 510         

Ala Ile Phe Met Trp Ser Ile Gly Asn Glu Ile Gly Glu Ala Asn Gly 
        515                 520                 525             

Asp Ala His Ser Leu Ala Thr Val Lys Arg Leu Val Lys Val Ile Lys 
    530                 535                 540                 

Asp Val Asp Lys Thr Arg Tyr Val Thr Met Gly Ala Asp Lys Phe Arg 
545                 550                 555                 560 

Phe Gly Asn Gly Ser Gly Gly His Glu Lys Ile Ala Asp Glu Leu Asp 
                565                 570                 575     

Ala Val Gly Phe Asn Tyr Ser Glu Asp Asn Tyr Lys Ala Leu Arg Ala 
            580                 585                 590         

Lys His Pro Lys Trp Leu Ile Tyr Gly Ser Glu Thr Ser Ser Ala Thr 
        595                 600                 605             

Arg Thr Arg Gly Ser Tyr Tyr Arg Pro Glu Arg Glu Leu Lys His Ser 
    610                 615                 620                 

Asn Gly Pro Glu Arg Asn Tyr Glu Gln Ser Asp Tyr Gly Asn Asp Arg 
625                 630                 635                 640 

Val Gly Trp Gly Lys Thr Ala Thr Ala Ser Trp Thr Phe Asp Arg Asp 
                645                 650                 655     

Asn Ala Gly Tyr Ala Gly Gln Phe Ile Trp Thr Gly Thr Asp Tyr Ile 
            660                 665                 670         

Gly Glu Pro Thr Pro Trp His Asn Gln Asn Gln Thr Pro Val Lys Ser 
        675                 680                 685             

Ser Tyr Phe Gly Ile Val Asp Thr Ala Gly Ile Pro Lys His Asp Phe 
    690                 695                 700                 

Tyr Leu Tyr Gln Ser Gln Trp Val Ser Val Lys Lys Lys Pro Met Val 
705                 710                 715                 720 

His Leu Leu Pro His Trp Asn Trp Glu Asn Lys Glu Leu Ala Ser Lys 
                725                 730                 735     

Val Ala Asp Ser Glu Gly Lys Ile Pro Val Arg Ala Tyr Ser Asn Ala 
            740                 745                 750         

Ser Ser Val Glu Leu Phe Leu Asn Gly Lys Ser Leu Gly Leu Lys Thr 
        755                 760                 765             

Phe Asn Lys Lys Gln Thr Ser Asp Gly Arg Thr Tyr Gln Glu Gly Ala 
    770                 775                 780                 

Asn Ala Asn Glu Leu Tyr Leu Glu Trp Lys Val Ala Tyr Gln Pro Gly 
785                 790                 795                 800 

Thr Leu Glu Ala Ile Ala Arg Asp Glu Ser Gly Lys Glu Ile Ala Arg 
                805                 810                 815     

Asp Lys Ile Thr Thr Ala Gly Lys Pro Ala Ala Val Arg Leu Ile Lys 
            820                 825                 830         

Glu Asp His Ala Ile Ala Ala Asp Gly Lys Asp Leu Thr Tyr Ile Tyr 
        835                 840                 845             

Tyr Glu Ile Val Asp Ser Gln Gly Asn Val Val Pro Thr Ala Asn Asn 
    850                 855                 860                 

Leu Val Arg Phe Gln Leu His Gly Gln Gly Gln Leu Val Gly Val Asp 
865                 870                 875                 880 

Asn Gly Glu Gln Ala Ser Arg Glu Arg Tyr Lys Ala Gln Ala Asp Gly 
                885                 890                 895     

Ser Trp Ile Arg Lys Ala Phe Asn Gly Lys Gly Val Ala Ile Val Lys 
            900                 905                 910         

Ser Thr Glu Gln Ala Gly Lys Phe Thr Leu Thr Ala His Ser Asp Leu 
        915                 920                 925             

Leu Lys Ser Asn Gln Val Thr Val Phe Thr Gly Lys Lys Glu Gly Gln 
    930                 935                 940                 

Glu Lys Thr Val Leu Gly Thr Glu Val Pro Lys Val Gln Thr Ile Ile 
945                 950                 955                 960 

Gly Glu Ala Pro Glu Met Pro Thr Thr Val Pro Phe Val Tyr Ser Asp 
                965                 970                 975     

Gly Ser Arg Ala Glu Arg Pro Val Thr Trp Ser Ser Val Asp Val Ser 
            980                 985                 990         

Lys Pro Gly Ile Val Thr Val Lys Gly Met Ala Asp Gly Arg Glu Val 
        995                 1000                1005            

Glu Ala Arg Val Glu Val Ile Ala Leu Lys Ser Glu Leu Pro Val Val 
    1010                1015                1020                

Lys Arg Ile Ala Pro Asn Thr Asp Leu Asn Ser Val Asp Lys Ser Val 
1025                1030                1035                1040

Ser Tyr Val Leu Ile Asp Gly Ser Val Glu Glu Tyr Glu Val Asp Lys 
                1045                1050                1055    

Trp Glu Ile Ala Glu Glu Asp Lys Ala Lys Gly Ser Gly Ser Gly Gly 
            1060                1065                1070        

Gly Gly Val Ser Ala Gln Glu Ser Ser Thr Tyr Thr Val Lys Glu Gly 
        1075                1080                1085            

Asp Thr Leu Ser Glu Ile Ala Glu Thr His Asn Thr Thr Val Glu Lys 
    1090                1095                1100                

Leu Ala Glu Asn Asn His Ile Asp Asn Ile His Leu Ile Tyr Val Asp 
1105                1110                1115                1120

Gln Glu Leu Val Ile Asp Gly Pro Val Ala Pro Val Ala Thr Pro Ala 
                1125                1130                1135    

Pro Ala Thr Tyr Ala Ala Pro Ala Ala Gln Asp Glu Thr Val Ser Ala 
            1140                1145                1150        

Pro Val Ala Glu Thr Pro Val Val Ser Glu Thr Val Val Ser Thr Val 
        1155                1160                1165            

Ser Gly Ser Glu Ala Glu Ala Lys Glu Trp Ile Ala Gln Lys Glu Ser 
    1170                1175                1180                

Gly Gly Ser Tyr Thr Ala Thr Asn Gly Arg Tyr Ile Gly Arg Tyr Gln 
1185                1190                1195                1200

Leu Thr Asp Ser Tyr Leu Asn Gly Asp Tyr Ser Ala Glu Asn Gln Glu 
                1205                1210                1215    

Arg Val Ala Asp Ala Tyr Val Ala Gly Arg Tyr Gly Ser Trp Thr Ala 
            1220                1225                1230        

Ala Lys Asn Phe Trp Leu Asn Asn Gly Trp Tyr Leu Glu His His His 
        1235                1240                1245            

His His His 
    1250    

<210>   222
<211>   1286
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Hybrid polypeptide

<400>   222
Met Ala Ser Ile Ala Glu Glu Asp Lys Ala Lys Leu Ala Ile Pro Gly 
1               5                   10                  15      

Ser Arg Ile Gln Ala Thr Gly Tyr Leu Glu Gly Gln Pro Ile His Ala 
            20                  25                  30          

Thr Leu Val Val Glu Glu Gly Asn Pro Ala Ala Pro Ala Val Pro Thr 
        35                  40                  45              

Val Thr Val Gly Gly Glu Ala Val Thr Gly Leu Thr Ser Gln Lys Pro 
    50                  55                  60                  

Met Gln Tyr Arg Thr Leu Ala Tyr Gly Ala Lys Leu Pro Glu Val Thr 
65                  70                  75                  80  

Ala Ser Ala Lys Asn Ala Ala Val Thr Val Leu Gln Ala Ser Ala Ala 
                85                  90                  95      

Asn Gly Met Arg Ala Ser Ile Phe Ile Gln Pro Lys Asp Gly Gly Pro 
            100                 105                 110         

Leu Gln Thr Tyr Ala Ile Gln Phe Leu Glu Glu Ala Pro Lys Ile Ala 
        115                 120                 125             

His Leu Ser Leu Gln Val Glu Lys Ala Asp Ser Leu Lys Glu Asp Gln 
    130                 135                 140                 

Thr Val Lys Leu Ser Val Arg Ala His Tyr Gln Asp Gly Thr Gln Ala 
145                 150                 155                 160 

Val Leu Pro Ala Asp Lys Val Thr Phe Ser Thr Ser Gly Glu Gly Glu 
                165                 170                 175     

Val Ala Ile Arg Lys Gly Met Leu Glu Leu His Lys Pro Gly Ala Val 
            180                 185                 190         

Thr Leu Asn Ala Glu Tyr Glu Gly Ala Lys Asp Gln Val Glu Leu Thr 
        195                 200                 205             

Ile Gln Ala Asn Thr Glu Lys Lys Ile Ala Gln Ser Ile Arg Pro Val 
    210                 215                 220                 

Asn Val Val Thr Asp Leu His Gln Glu Pro Ser Leu Pro Ala Thr Val 
225                 230                 235                 240 

Thr Val Glu Tyr Asp Lys Gly Phe Pro Lys Thr His Lys Val Thr Trp 
                245                 250                 255     

Gln Ala Ile Pro Lys Glu Lys Leu Asp Ser Tyr Gln Thr Phe Glu Val 
            260                 265                 270         

Leu Gly Lys Val Glu Gly Ile Asp Leu Glu Ala Arg Ala Lys Val Ser 
        275                 280                 285             

Val Glu Gly Ile Val Ser Val Glu Glu Val Ser Val Thr Thr Pro Ile 
    290                 295                 300                 

Ala Glu Ala Pro Gln Leu Pro Glu Ser Val Arg Thr Tyr Asp Ser Asn 
305                 310                 315                 320 

Gly His Val Ser Ser Ala Lys Val Ala Trp Asp Ala Ile Arg Pro Glu 
                325                 330                 335     

Gln Tyr Ala Lys Glu Gly Val Phe Thr Val Asn Gly Arg Leu Glu Gly 
            340                 345                 350         

Thr Gln Leu Thr Thr Lys Leu His Val Arg Val Ser Ala Gln Thr Glu 
        355                 360                 365             

Gln Gly Ala Asn Ile Ser Asp Gln Trp Thr Gly Ser Glu Leu Pro Leu 
    370                 375                 380                 

Ala Phe Ala Ser Asp Ser Asn Pro Ser Asp Pro Val Ser Asn Val Asn 
385                 390                 395                 400 

Asp Lys Leu Ile Ser Tyr Asn Asn Gln Pro Ala Asn Arg Trp Thr Asn 
                405                 410                 415     

Trp Asn Arg Thr Asn Pro Glu Ala Ser Val Gly Val Leu Phe Gly Asp 
            420                 425                 430         

Ser Gly Ile Leu Ser Lys Arg Ser Val Asp Asn Leu Ser Val Gly Phe 
        435                 440                 445             

His Glu Asp His Gly Val Gly Val Pro Lys Ser Tyr Val Ile Glu Tyr 
    450                 455                 460                 

Tyr Val Gly Lys Thr Val Pro Thr Ala Pro Lys Asn Pro Ser Phe Val 
465                 470                 475                 480 

Gly Asn Glu Asp His Val Phe Asn Asp Ser Ala Asn Trp Lys Pro Val 
                485                 490                 495     

Thr Asn Leu Lys Ala Pro Ala Gln Leu Lys Ala Gly Glu Met Asn His 
            500                 505                 510         

Phe Ser Phe Asp Lys Val Glu Thr Tyr Ala Val Arg Ile Arg Met Val 
        515                 520                 525             

Lys Ala Asp Asn Lys Arg Gly Thr Ser Ile Thr Glu Val Gln Ile Phe 
    530                 535                 540                 

Ala Lys Gln Val Ala Ala Ala Lys Gln Gly Gln Thr Arg Ile Gln Val 
545                 550                 555                 560 

Asp Gly Lys Asp Leu Ala Asn Phe Asn Pro Asp Leu Thr Asp Tyr Tyr 
                565                 570                 575     

Leu Glu Ser Val Asp Gly Lys Val Pro Ala Val Thr Ala Ser Val Ser 
            580                 585                 590         

Asn Asn Gly Leu Ala Thr Val Val Pro Ser Val Arg Glu Gly Glu Pro 
        595                 600                 605             

Val Arg Val Ile Ala Lys Ala Glu Asn Gly Asp Ile Leu Gly Glu Tyr 
    610                 615                 620                 

Arg Leu His Phe Thr Lys Asp Lys Ser Leu Leu Ser His Lys Pro Val 
625                 630                 635                 640 

Ala Ala Val Lys Gln Ala Arg Leu Leu Gln Val Gly Gln Ala Leu Glu 
                645                 650                 655     

Leu Pro Thr Lys Val Pro Val Tyr Phe Thr Gly Lys Asp Gly Tyr Glu 
            660                 665                 670         

Thr Lys Asp Leu Thr Val Glu Trp Glu Glu Val Pro Ala Glu Asn Leu 
        675                 680                 685             

Thr Lys Ala Gly Gln Phe Thr Val Arg Gly Arg Val Leu Gly Ser Asn 
    690                 695                 700                 

Leu Val Ala Glu Ile Thr Val Arg Val Thr Asp Lys Leu Gly Glu Thr 
705                 710                 715                 720 

Leu Ser Asp Asn Pro Asn Tyr Asp Glu Asn Ser Asn Gln Ala Phe Ala 
                725                 730                 735     

Ser Ala Thr Asn Asp Ile Asp Lys Asn Ser His Asp Arg Val Asp Tyr 
            740                 745                 750         

Leu Asn Asp Gly Asp His Ser Glu Asn Arg Arg Trp Thr Asn Trp Ser 
        755                 760                 765             

Pro Thr Pro Ser Ser Asn Pro Glu Val Ser Ala Gly Val Ile Phe Arg 
    770                 775                 780                 

Glu Asn Gly Lys Ile Val Glu Arg Thr Val Thr Gln Gly Lys Val Gln 
785                 790                 795                 800 

Phe Phe Ala Asp Ser Gly Thr Asp Ala Pro Ser Lys Leu Val Leu Glu 
                805                 810                 815     

Arg Tyr Val Gly Pro Glu Phe Glu Val Pro Thr Tyr Tyr Ser Asn Tyr 
            820                 825                 830         

Gln Ala Tyr Asp Ala Asp His Pro Phe Asn Asn Pro Glu Asn Trp Glu 
        835                 840                 845             

Ala Val Pro Tyr Arg Ala Asp Lys Asp Ile Ala Ala Gly Asp Glu Ile 
    850                 855                 860                 

Asn Val Thr Phe Lys Ala Ile Lys Ala Lys Ala Met Arg Trp Arg Met 
865                 870                 875                 880 

Glu Arg Lys Ala Asp Lys Ser Gly Val Ala Met Ile Glu Met Thr Phe 
                885                 890                 895     

Leu Ala Pro Ser Glu Leu Pro Gln Glu Ser Thr Gln Ser Lys Ile Leu 
            900                 905                 910         

Val Asp Gly Lys Glu Leu Ala Asp Phe Ala Glu Asn Arg Gln Asp Tyr 
        915                 920                 925             

Gln Ile Thr Tyr Lys Gly Gln Arg Pro Lys Val Ser Val Glu Glu Asn 
    930                 935                 940                 

Asn Gln Val Ala Ser Thr Val Val Asp Ser Gly Glu Asp Ser Phe Pro 
945                 950                 955                 960 

Val Leu Val Arg Leu Val Ser Glu Ser Gly Lys Gln Val Lys Glu Tyr 
                965                 970                 975     

Arg Ile His Leu Thr Lys Glu Lys Pro Val Ser Glu Lys Thr Val Ala 
            980                 985                 990         

Ala Val Gln Glu Asp Leu Pro Lys Ile Glu Phe Val Glu Lys Asp Leu 
        995                 1000                1005            

Ala Tyr Lys Thr Val Glu Lys Lys Asp Ser Thr Leu Tyr Leu Gly Glu 
    1010                1015                1020                

Thr Arg Val Glu Gln Glu Gly Lys Val Gly Lys Glu Arg Ile Phe Thr 
1025                1030                1035                1040

Ala Ile Asn Pro Asp Gly Ser Lys Glu Glu Lys Leu Arg Glu Val Val 
                1045                1050                1055    

Glu Val Pro Thr Asp Arg Ile Val Leu Val Gly Thr Lys Pro Val Ala 
            1060                1065                1070        

Gln Glu Ala Lys Lys Pro Gln Val Ser Glu Lys Ala Asp Thr Lys Pro 
        1075                1080                1085            

Ile Asp Ser Ser Glu Ala Ser Gln Thr Asn Lys Ala Gln Gly Ser Gly 
    1090                1095                1100                

Ser Gly Gly Gly Gly Val Ser Ala Gln Glu Ser Ser Thr Tyr Thr Val 
1105                1110                1115                1120

Lys Glu Gly Asp Thr Leu Ser Glu Ile Ala Glu Thr His Asn Thr Thr 
                1125                1130                1135    

Val Glu Lys Leu Ala Glu Asn Asn His Ile Asp Asn Ile His Leu Ile 
            1140                1145                1150        

Tyr Val Asp Gln Glu Leu Val Ile Asp Gly Pro Val Ala Pro Val Ala 
        1155                1160                1165            

Thr Pro Ala Pro Ala Thr Tyr Ala Ala Pro Ala Ala Gln Asp Glu Thr 
    1170                1175                1180                

Val Ser Ala Pro Val Ala Glu Thr Pro Val Val Ser Glu Thr Val Val 
1185                1190                1195                1200

Ser Thr Val Ser Gly Ser Glu Ala Glu Ala Lys Glu Trp Ile Ala Gln 
                1205                1210                1215    

Lys Glu Ser Gly Gly Ser Tyr Thr Ala Thr Asn Gly Arg Tyr Ile Gly 
            1220                1225                1230        

Arg Tyr Gln Leu Thr Asp Ser Tyr Leu Asn Gly Asp Tyr Ser Ala Glu 
        1235                1240                1245            

Asn Gln Glu Arg Val Ala Asp Ala Tyr Val Ala Gly Arg Tyr Gly Ser 
    1250                1255                1260                

Trp Thr Ala Ala Lys Asn Phe Trp Leu Asn Asn Gly Trp Tyr Leu Glu 
1265                1270                1275                1280

His His His His His His 
                1285    

<210>   223
<211>   2541
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Hybrid polypeptide

<400>   223
Met Ala Ser Asp Glu Thr Leu Ile Thr His Thr Ala Glu Lys Pro Lys 
1               5                   10                  15      

Glu Glu Lys Met Ile Val Glu Glu Lys Ala Asp Lys Ala Leu Glu Thr 
            20                  25                  30          

Lys Asn Ile Val Glu Arg Thr Glu Gln Ser Glu Pro Ser Ser Thr Glu 
        35                  40                  45              

Ala Ile Ala Ser Glu Lys Lys Glu Asp Glu Ala Val Thr Pro Lys Glu 
    50                  55                  60                  

Glu Lys Val Ser Ala Lys Pro Glu Glu Lys Ala Pro Arg Ile Glu Ser 
65                  70                  75                  80  

Gln Ala Ser Asn Gln Glu Lys Pro Leu Lys Glu Asp Ala Lys Ala Val 
                85                  90                  95      

Thr Asn Glu Glu Val Asn Gln Met Ile Glu Asp Arg Lys Val Asp Phe 
            100                 105                 110         

Asn Gln Asn Trp Tyr Phe Lys Leu Asn Ala Asn Ser Lys Glu Ala Ile 
        115                 120                 125             

Lys Pro Asp Ala Asp Val Ser Thr Trp Lys Lys Leu Asp Leu Pro Tyr 
    130                 135                 140                 

Asp Trp Ser Ile Phe Asn Asp Phe Asp His Glu Ser Pro Ala Gln Asn 
145                 150                 155                 160 

Glu Gly Gly Gln Leu Asn Gly Gly Glu Ala Trp Tyr Arg Lys Thr Phe 
                165                 170                 175     

Lys Leu Asp Glu Lys Asp Leu Lys Lys Asn Val Arg Leu Thr Phe Asp 
            180                 185                 190         

Gly Val Tyr Met Asp Ser Gln Val Tyr Val Asn Gly Gln Leu Val Gly 
        195                 200                 205             

His Tyr Pro Asn Gly Tyr Asn Gln Phe Ser Tyr Asp Ile Thr Lys Tyr 
    210                 215                 220                 

Leu Gln Lys Asp Gly Arg Glu Asn Val Ile Ala Val His Ala Val Asn 
225                 230                 235                 240 

Lys Gln Pro Ser Ser Arg Trp Tyr Ser Gly Ser Gly Ile Tyr Arg Asp 
                245                 250                 255     

Val Thr Leu Gln Val Thr Asp Lys Val His Val Glu Lys Asn Gly Thr 
            260                 265                 270         

Thr Ile Leu Thr Pro Lys Leu Glu Glu Gln Gln His Gly Lys Val Glu 
        275                 280                 285             

Thr His Val Thr Ser Lys Ile Val Asn Thr Asp Asp Lys Asp His Glu 
    290                 295                 300                 

Leu Val Ala Glu Tyr Gln Ile Val Glu Arg Gly Gly His Ala Val Thr 
305                 310                 315                 320 

Gly Leu Val Arg Thr Ala Ser Arg Thr Leu Lys Ala His Glu Ser Thr 
                325                 330                 335     

Ser Leu Asp Ala Ile Leu Glu Val Glu Arg Pro Lys Leu Trp Thr Val 
            340                 345                 350         

Leu Asn Asp Lys Pro Ala Leu Tyr Glu Leu Ile Thr Arg Val Tyr Arg 
        355                 360                 365             

Asp Gly Gln Leu Val Asp Ala Lys Lys Asp Leu Phe Gly Tyr Arg Tyr 
    370                 375                 380                 

Tyr His Trp Thr Pro Asn Glu Gly Phe Ser Leu Asn Gly Glu Arg Ile 
385                 390                 395                 400 

Lys Phe His Gly Val Ser Leu His His Asp His Gly Ala Leu Gly Ala 
                405                 410                 415     

Glu Glu Asn Tyr Lys Ala Glu Tyr Arg Arg Leu Lys Gln Met Lys Glu 
            420                 425                 430         

Met Gly Val Asn Ser Ile Arg Thr Thr His Asn Pro Ala Ser Glu Gln 
        435                 440                 445             

Thr Leu Gln Ile Ala Ala Glu Leu Gly Leu Leu Val Gln Glu Glu Ala 
    450                 455                 460                 

Phe Asp Thr Trp Tyr Gly Gly Lys Lys Pro Tyr Asp Tyr Gly Arg Phe 
465                 470                 475                 480 

Phe Glu Lys Asp Ala Thr His Pro Glu Ala Arg Lys Gly Glu Lys Trp 
                485                 490                 495     

Ser Asp Phe Asp Leu Arg Thr Met Val Glu Arg Gly Lys Asn Asn Pro 
            500                 505                 510         

Ala Ile Phe Met Trp Ser Ile Gly Asn Glu Ile Gly Glu Ala Asn Gly 
        515                 520                 525             

Asp Ala His Ser Leu Ala Thr Val Lys Arg Leu Val Lys Val Ile Lys 
    530                 535                 540                 

Asp Val Asp Lys Thr Arg Tyr Val Thr Met Gly Ala Asp Lys Phe Arg 
545                 550                 555                 560 

Phe Gly Asn Gly Ser Gly Gly His Glu Lys Ile Ala Asp Glu Leu Asp 
                565                 570                 575     

Ala Val Gly Phe Asn Tyr Ser Glu Asp Asn Tyr Lys Ala Leu Arg Ala 
            580                 585                 590         

Lys His Pro Lys Trp Leu Ile Tyr Gly Ser Glu Thr Ser Ser Ala Thr 
        595                 600                 605             

Arg Thr Arg Gly Ser Tyr Tyr Arg Pro Glu Arg Glu Leu Lys His Ser 
    610                 615                 620                 

Asn Gly Pro Glu Arg Asn Tyr Glu Gln Ser Asp Tyr Gly Asn Asp Arg 
625                 630                 635                 640 

Val Gly Trp Gly Lys Thr Ala Thr Ala Ser Trp Thr Phe Asp Arg Asp 
                645                 650                 655     

Asn Ala Gly Tyr Ala Gly Gln Phe Ile Trp Thr Gly Thr Asp Tyr Ile 
            660                 665                 670         

Gly Glu Pro Thr Pro Trp His Asn Gln Asn Gln Thr Pro Val Lys Ser 
        675                 680                 685             

Ser Tyr Phe Gly Ile Val Asp Thr Ala Gly Ile Pro Lys His Asp Phe 
    690                 695                 700                 

Tyr Leu Tyr Gln Ser Gln Trp Val Ser Val Lys Lys Lys Pro Met Val 
705                 710                 715                 720 

His Leu Leu Pro His Trp Asn Trp Glu Asn Lys Glu Leu Ala Ser Lys 
                725                 730                 735     

Val Ala Asp Ser Glu Gly Lys Ile Pro Val Arg Ala Tyr Ser Asn Ala 
            740                 745                 750         

Ser Ser Val Glu Leu Phe Leu Asn Gly Lys Ser Leu Gly Leu Lys Thr 
        755                 760                 765             

Phe Asn Lys Lys Gln Thr Ser Asp Gly Arg Thr Tyr Gln Glu Gly Ala 
    770                 775                 780                 

Asn Ala Asn Glu Leu Tyr Leu Glu Trp Lys Val Ala Tyr Gln Pro Gly 
785                 790                 795                 800 

Thr Leu Glu Ala Ile Ala Arg Asp Glu Ser Gly Lys Glu Ile Ala Arg 
                805                 810                 815     

Asp Lys Ile Thr Thr Ala Gly Lys Pro Ala Ala Val Arg Leu Ile Lys 
            820                 825                 830         

Glu Asp His Ala Ile Ala Ala Asp Gly Lys Asp Leu Thr Tyr Ile Tyr 
        835                 840                 845             

Tyr Glu Ile Val Asp Ser Gln Gly Asn Val Val Pro Thr Ala Asn Asn 
    850                 855                 860                 

Leu Val Arg Phe Gln Leu His Gly Gln Gly Gln Leu Val Gly Val Asp 
865                 870                 875                 880 

Asn Gly Glu Gln Ala Ser Arg Glu Arg Tyr Lys Ala Gln Ala Asp Gly 
                885                 890                 895     

Ser Trp Ile Arg Lys Ala Phe Asn Gly Lys Gly Val Ala Ile Val Lys 
            900                 905                 910         

Ser Thr Glu Gln Ala Gly Lys Phe Thr Leu Thr Ala His Ser Asp Leu 
        915                 920                 925             

Leu Lys Ser Asn Gln Val Thr Val Phe Thr Gly Lys Lys Glu Gly Gln 
    930                 935                 940                 

Glu Lys Thr Val Leu Gly Thr Glu Val Pro Lys Val Gln Thr Ile Ile 
945                 950                 955                 960 

Gly Glu Ala Pro Glu Met Pro Thr Thr Val Pro Phe Val Tyr Ser Asp 
                965                 970                 975     

Gly Ser Arg Ala Glu Arg Pro Val Thr Trp Ser Ser Val Asp Val Ser 
            980                 985                 990         

Lys Pro Gly Ile Val Thr Val Lys Gly Met Ala Asp Gly Arg Glu Val 
        995                 1000                1005            

Glu Ala Arg Val Glu Val Ile Ala Leu Lys Ser Glu Leu Pro Val Val 
    1010                1015                1020                

Lys Arg Ile Ala Pro Asn Thr Asp Leu Asn Ser Val Asp Lys Ser Val 
1025                1030                1035                1040

Ser Tyr Val Leu Ile Asp Gly Ser Val Glu Glu Tyr Glu Val Asp Lys 
                1045                1050                1055    

Trp Glu Ile Ala Glu Glu Asp Lys Ala Lys Leu Ala Ile Pro Gly Ser 
            1060                1065                1070        

Arg Ile Gln Ala Thr Gly Tyr Leu Glu Gly Gln Pro Ile His Ala Thr 
        1075                1080                1085            

Leu Val Val Glu Glu Gly Asn Pro Ala Ala Pro Ala Val Pro Thr Val 
    1090                1095                1100                

Thr Val Gly Gly Glu Ala Val Thr Gly Leu Thr Ser Gln Lys Pro Met 
1105                1110                1115                1120

Gln Tyr Arg Thr Leu Ala Tyr Gly Ala Lys Leu Pro Glu Val Thr Ala 
                1125                1130                1135    

Ser Ala Lys Asn Ala Ala Val Thr Val Leu Gln Ala Ser Ala Ala Asn 
            1140                1145                1150        

Gly Met Arg Ala Ser Ile Phe Ile Gln Pro Lys Asp Gly Gly Pro Leu 
        1155                1160                1165            

Gln Thr Tyr Ala Ile Gln Phe Leu Glu Glu Ala Pro Lys Ile Ala His 
    1170                1175                1180                

Leu Ser Leu Gln Val Glu Lys Ala Asp Ser Leu Lys Glu Asp Gln Thr 
1185                1190                1195                1200

Val Lys Leu Ser Val Arg Ala His Tyr Gln Asp Gly Thr Gln Ala Val 
                1205                1210                1215    

Leu Pro Ala Asp Lys Val Thr Phe Ser Thr Ser Gly Glu Gly Glu Val 
            1220                1225                1230        

Ala Ile Arg Lys Gly Met Leu Glu Leu His Lys Pro Gly Ala Val Thr 
        1235                1240                1245            

Leu Asn Ala Glu Tyr Glu Gly Ala Lys Asp Gln Val Glu Leu Thr Ile 
    1250                1255                1260                

Gln Ala Asn Thr Glu Lys Lys Ile Ala Gln Ser Ile Arg Pro Val Asn 
1265                1270                1275                1280

Val Val Thr Asp Leu His Gln Glu Pro Ser Leu Pro Ala Thr Val Thr 
                1285                1290                1295    

Val Glu Tyr Asp Lys Gly Phe Pro Lys Thr His Lys Val Thr Trp Gln 
            1300                1305                1310        

Ala Ile Pro Lys Glu Lys Leu Asp Ser Tyr Gln Thr Phe Glu Val Leu 
        1315                1320                1325            

Gly Lys Val Glu Gly Ile Asp Leu Glu Ala Arg Ala Lys Val Ser Val 
    1330                1335                1340                

Glu Gly Ile Val Ser Val Glu Glu Val Ser Val Thr Thr Pro Ile Ala 
1345                1350                1355                1360

Glu Ala Pro Gln Leu Pro Glu Ser Val Arg Thr Tyr Asp Ser Asn Gly 
                1365                1370                1375    

His Val Ser Ser Ala Lys Val Ala Trp Asp Ala Ile Arg Pro Glu Gln 
            1380                1385                1390        

Tyr Ala Lys Glu Gly Val Phe Thr Val Asn Gly Arg Leu Glu Gly Thr 
        1395                1400                1405            

Gln Leu Thr Thr Lys Leu His Val Arg Val Ser Ala Gln Thr Glu Gln 
    1410                1415                1420                

Gly Ala Asn Ile Ser Asp Gln Trp Thr Gly Ser Glu Leu Pro Leu Ala 
1425                1430                1435                1440

Phe Ala Ser Asp Ser Asn Pro Ser Asp Pro Val Ser Asn Val Asn Asp 
                1445                1450                1455    

Lys Leu Ile Ser Tyr Asn Asn Gln Pro Ala Asn Arg Trp Thr Asn Trp 
            1460                1465                1470        

Asn Arg Thr Asn Pro Glu Ala Ser Val Gly Val Leu Phe Gly Asp Ser 
        1475                1480                1485            

Gly Ile Leu Ser Lys Arg Ser Val Asp Asn Leu Ser Val Gly Phe His 
    1490                1495                1500                

Glu Asp His Gly Val Gly Val Pro Lys Ser Tyr Val Ile Glu Tyr Tyr 
1505                1510                1515                1520

Val Gly Lys Thr Val Pro Thr Ala Pro Lys Asn Pro Ser Phe Val Gly 
                1525                1530                1535    

Asn Glu Asp His Val Phe Asn Asp Ser Ala Asn Trp Lys Pro Val Thr 
            1540                1545                1550        

Asn Leu Lys Ala Pro Ala Gln Leu Lys Ala Gly Glu Met Asn His Phe 
        1555                1560                1565            

Ser Phe Asp Lys Val Glu Thr Tyr Ala Val Arg Ile Arg Met Val Lys 
    1570                1575                1580                

Ala Asp Asn Lys Arg Gly Thr Ser Ile Thr Glu Val Gln Ile Phe Ala 
1585                1590                1595                1600

Lys Gln Val Ala Ala Ala Lys Gln Gly Gln Thr Arg Ile Gln Val Asp 
                1605                1610                1615    

Gly Lys Asp Leu Ala Asn Phe Asn Pro Asp Leu Thr Asp Tyr Tyr Leu 
            1620                1625                1630        

Glu Ser Val Asp Gly Lys Val Pro Ala Val Thr Ala Ser Val Ser Asn 
        1635                1640                1645            

Asn Gly Leu Ala Thr Val Val Pro Ser Val Arg Glu Gly Glu Pro Val 
    1650                1655                1660                

Arg Val Ile Ala Lys Ala Glu Asn Gly Asp Ile Leu Gly Glu Tyr Arg 
1665                1670                1675                1680

Leu His Phe Thr Lys Asp Lys Ser Leu Leu Ser His Lys Pro Val Ala 
                1685                1690                1695    

Ala Val Lys Gln Ala Arg Leu Leu Gln Val Gly Gln Ala Leu Glu Leu 
            1700                1705                1710        

Pro Thr Lys Val Pro Val Tyr Phe Thr Gly Lys Asp Gly Tyr Glu Thr 
        1715                1720                1725            

Lys Asp Leu Thr Val Glu Trp Glu Glu Val Pro Ala Glu Asn Leu Thr 
    1730                1735                1740                

Lys Ala Gly Gln Phe Thr Val Arg Gly Arg Val Leu Gly Ser Asn Leu 
1745                1750                1755                1760

Val Ala Glu Ile Thr Val Arg Val Thr Asp Lys Leu Gly Glu Thr Leu 
                1765                1770                1775    

Ser Asp Asn Pro Asn Tyr Asp Glu Asn Ser Asn Gln Ala Phe Ala Ser 
            1780                1785                1790        

Ala Thr Asn Asp Ile Asp Lys Asn Ser His Asp Arg Val Asp Tyr Leu 
        1795                1800                1805            

Asn Asp Gly Asp His Ser Glu Asn Arg Arg Trp Thr Asn Trp Ser Pro 
    1810                1815                1820                

Thr Pro Ser Ser Asn Pro Glu Val Ser Ala Gly Val Ile Phe Arg Glu 
1825                1830                1835                1840

Asn Gly Lys Ile Val Glu Arg Thr Val Thr Gln Gly Lys Val Gln Phe 
                1845                1850                1855    

Phe Ala Asp Ser Gly Thr Asp Ala Pro Ser Lys Leu Val Leu Glu Arg 
            1860                1865                1870        

Tyr Val Gly Pro Glu Phe Glu Val Pro Thr Tyr Tyr Ser Asn Tyr Gln 
        1875                1880                1885            

Ala Tyr Asp Ala Asp His Pro Phe Asn Asn Pro Glu Asn Trp Glu Ala 
    1890                1895                1900                

Val Pro Tyr Arg Ala Asp Lys Asp Ile Ala Ala Gly Asp Glu Ile Asn 
1905                1910                1915                1920

Val Thr Phe Lys Ala Ile Lys Ala Lys Ala Met Arg Trp Arg Met Glu 
                1925                1930                1935    

Arg Lys Ala Asp Lys Ser Gly Val Ala Met Ile Glu Met Thr Phe Leu 
            1940                1945                1950        

Ala Pro Ser Glu Leu Pro Gln Glu Ser Thr Gln Ser Lys Ile Leu Val 
        1955                1960                1965            

Asp Gly Lys Glu Leu Ala Asp Phe Ala Glu Asn Arg Gln Asp Tyr Gln 
    1970                1975                1980                

Ile Thr Tyr Lys Gly Gln Arg Pro Lys Val Ser Val Glu Glu Asn Asn 
1985                1990                1995                2000

Gln Val Ala Ser Thr Val Val Asp Ser Gly Glu Asp Ser Phe Pro Val 
                2005                2010                2015    

Leu Val Arg Leu Val Ser Glu Ser Gly Lys Gln Val Lys Glu Tyr Arg 
            2020                2025                2030        

Ile His Leu Thr Lys Glu Lys Pro Val Ser Glu Lys Thr Val Ala Ala 
        2035                2040                2045            

Val Gln Glu Asp Leu Pro Lys Ile Glu Phe Val Glu Lys Asp Leu Ala 
    2050                2055                2060                

Tyr Lys Thr Val Glu Lys Lys Asp Ser Thr Leu Tyr Leu Gly Glu Thr 
2065                2070                2075                2080

Arg Val Glu Gln Glu Gly Lys Val Gly Lys Glu Arg Ile Phe Thr Ala 
                2085                2090                2095    

Ile Asn Pro Asp Gly Ser Lys Glu Glu Lys Leu Arg Glu Val Val Glu 
            2100                2105                2110        

Val Pro Thr Asp Arg Ile Val Leu Val Gly Thr Lys Pro Val Ala Gln 
        2115                2120                2125            

Glu Ala Lys Lys Pro Gln Val Ser Glu Lys Ala Asp Thr Lys Pro Ile 
    2130                2135                2140                

Asp Ser Ser Glu Ala Ser Gln Thr Asn Lys Ala Gln Gly Ser Gly Ser 
2145                2150                2155                2160

Gly Gly Gly Gly Ala Glu Thr Thr Asp Asp Lys Ile Ala Ala Gln Asp 
                2165                2170                2175    

Asn Lys Ile Ser Asn Leu Thr Ala Gln Gln Gln Glu Ala Gln Lys Gln 
            2180                2185                2190        

Val Asp Gln Ile Gln Glu Gln Val Ser Ala Ile Gln Ala Glu Gln Ser 
        2195                2200                2205            

Asn Leu Gln Ala Glu Asn Asp Arg Leu Gln Ala Glu Ser Lys Lys Leu 
    2210                2215                2220                

Glu Gly Glu Ile Thr Glu Leu Ser Lys Asn Ile Val Ser Arg Asn Gln 
2225                2230                2235                2240

Ser Leu Glu Lys Gln Ala Arg Ser Ala Gln Thr Asn Gly Ala Val Thr 
                2245                2250                2255    

Ser Tyr Ile Asn Thr Ile Val Asn Ser Lys Ser Ile Thr Glu Ala Ile 
            2260                2265                2270        

Ser Arg Val Ala Ala Met Ser Glu Ile Val Ser Ala Asn Asn Lys Met 
        2275                2280                2285            

Leu Glu Gln Gln Lys Ala Asp Lys Lys Ala Ile Ser Glu Lys Gln Val 
    2290                2295                2300                

Ala Asn Asn Asp Ala Ile Asn Thr Val Ile Ala Asn Gln Gln Lys Leu 
2305                2310                2315                2320

Ala Asp Asp Ala Gln Ala Leu Thr Thr Lys Gln Ala Glu Leu Lys Ala 
                2325                2330                2335    

Ala Glu Leu Ser Leu Ala Ala Glu Lys Ala Thr Ala Glu Gly Glu Lys 
            2340                2345                2350        

Ala Ser Leu Leu Glu Gln Lys Ala Ala Ala Glu Ala Glu Ala Arg Ala 
        2355                2360                2365            

Ala Ala Val Ala Glu Ala Ala Tyr Lys Glu Lys Arg Ala Ser Gln Gln 
    2370                2375                2380                

Gln Ser Val Leu Ala Ser Ala Asn Thr Asn Leu Thr Ala Gln Val Gln 
2385                2390                2395                2400

Ala Val Ser Glu Ser Ala Ala Ala Pro Val Arg Ala Lys Val Arg Pro 
                2405                2410                2415    

Thr Tyr Ser Thr Asn Ala Ser Ser Tyr Pro Ile Gly Glu Cys Thr Trp 
            2420                2425                2430        

Gly Val Lys Thr Leu Ala Pro Trp Ala Gly Asp Tyr Trp Gly Asn Gly 
        2435                2440                2445            

Ala Gln Trp Ala Thr Ser Ala Ala Ala Ala Gly Phe Arg Thr Gly Ser 
    2450                2455                2460                

Thr Pro Gln Val Gly Ala Ile Ala Cys Trp Asn Asp Gly Gly Tyr Gly 
2465                2470                2475                2480

His Val Ala Val Val Thr Ala Val Glu Ser Thr Thr Arg Ile Gln Val 
                2485                2490                2495    

Ser Glu Ser Asn Tyr Ala Gly Asn Arg Thr Ile Gly Asn His Arg Gly 
            2500                2505                2510        

Trp Phe Asn Pro Thr Thr Thr Ser Glu Gly Phe Val Thr Tyr Ile Tyr 
        2515                2520                2525            

Ala Asp Ala Ala Ala Leu Glu His His His His His His 
    2530                2535                2540    

<210>   224
<211>   1451
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Hybrid polypeptide

<400>   224
Met Ala Ser Asp Glu Thr Leu Ile Thr His Thr Ala Glu Lys Pro Lys 
1               5                   10                  15      

Glu Glu Lys Met Ile Val Glu Glu Lys Ala Asp Lys Ala Leu Glu Thr 
            20                  25                  30          

Lys Asn Ile Val Glu Arg Thr Glu Gln Ser Glu Pro Ser Ser Thr Glu 
        35                  40                  45              

Ala Ile Ala Ser Glu Lys Lys Glu Asp Glu Ala Val Thr Pro Lys Glu 
    50                  55                  60                  

Glu Lys Val Ser Ala Lys Pro Glu Glu Lys Ala Pro Arg Ile Glu Ser 
65                  70                  75                  80  

Gln Ala Ser Asn Gln Glu Lys Pro Leu Lys Glu Asp Ala Lys Ala Val 
                85                  90                  95      

Thr Asn Glu Glu Val Asn Gln Met Ile Glu Asp Arg Lys Val Asp Phe 
            100                 105                 110         

Asn Gln Asn Trp Tyr Phe Lys Leu Asn Ala Asn Ser Lys Glu Ala Ile 
        115                 120                 125             

Lys Pro Asp Ala Asp Val Ser Thr Trp Lys Lys Leu Asp Leu Pro Tyr 
    130                 135                 140                 

Asp Trp Ser Ile Phe Asn Asp Phe Asp His Glu Ser Pro Ala Gln Asn 
145                 150                 155                 160 

Glu Gly Gly Gln Leu Asn Gly Gly Glu Ala Trp Tyr Arg Lys Thr Phe 
                165                 170                 175     

Lys Leu Asp Glu Lys Asp Leu Lys Lys Asn Val Arg Leu Thr Phe Asp 
            180                 185                 190         

Gly Val Tyr Met Asp Ser Gln Val Tyr Val Asn Gly Gln Leu Val Gly 
        195                 200                 205             

His Tyr Pro Asn Gly Tyr Asn Gln Phe Ser Tyr Asp Ile Thr Lys Tyr 
    210                 215                 220                 

Leu Gln Lys Asp Gly Arg Glu Asn Val Ile Ala Val His Ala Val Asn 
225                 230                 235                 240 

Lys Gln Pro Ser Ser Arg Trp Tyr Ser Gly Ser Gly Ile Tyr Arg Asp 
                245                 250                 255     

Val Thr Leu Gln Val Thr Asp Lys Val His Val Glu Lys Asn Gly Thr 
            260                 265                 270         

Thr Ile Leu Thr Pro Lys Leu Glu Glu Gln Gln His Gly Lys Val Glu 
        275                 280                 285             

Thr His Val Thr Ser Lys Ile Val Asn Thr Asp Asp Lys Asp His Glu 
    290                 295                 300                 

Leu Val Ala Glu Tyr Gln Ile Val Glu Arg Gly Gly His Ala Val Thr 
305                 310                 315                 320 

Gly Leu Val Arg Thr Ala Ser Arg Thr Leu Lys Ala His Glu Ser Thr 
                325                 330                 335     

Ser Leu Asp Ala Ile Leu Glu Val Glu Arg Pro Lys Leu Trp Thr Val 
            340                 345                 350         

Leu Asn Asp Lys Pro Ala Leu Tyr Glu Leu Ile Thr Arg Val Tyr Arg 
        355                 360                 365             

Asp Gly Gln Leu Val Asp Ala Lys Lys Asp Leu Phe Gly Tyr Arg Tyr 
    370                 375                 380                 

Tyr His Trp Thr Pro Asn Glu Gly Phe Ser Leu Asn Gly Glu Arg Ile 
385                 390                 395                 400 

Lys Phe His Gly Val Ser Leu His His Asp His Gly Ala Leu Gly Ala 
                405                 410                 415     

Glu Glu Asn Tyr Lys Ala Glu Tyr Arg Arg Leu Lys Gln Met Lys Glu 
            420                 425                 430         

Met Gly Val Asn Ser Ile Arg Thr Thr His Asn Pro Ala Ser Glu Gln 
        435                 440                 445             

Thr Leu Gln Ile Ala Ala Glu Leu Gly Leu Leu Val Gln Glu Glu Ala 
    450                 455                 460                 

Phe Asp Thr Trp Tyr Gly Gly Lys Lys Pro Tyr Asp Tyr Gly Arg Phe 
465                 470                 475                 480 

Phe Glu Lys Asp Ala Thr His Pro Glu Ala Arg Lys Gly Glu Lys Trp 
                485                 490                 495     

Ser Asp Phe Asp Leu Arg Thr Met Val Glu Arg Gly Lys Asn Asn Pro 
            500                 505                 510         

Ala Ile Phe Met Trp Ser Ile Gly Asn Glu Ile Gly Glu Ala Asn Gly 
        515                 520                 525             

Asp Ala His Ser Leu Ala Thr Val Lys Arg Leu Val Lys Val Ile Lys 
    530                 535                 540                 

Asp Val Asp Lys Thr Arg Tyr Val Thr Met Gly Ala Asp Lys Phe Arg 
545                 550                 555                 560 

Phe Gly Asn Gly Ser Gly Gly His Glu Lys Ile Ala Asp Glu Leu Asp 
                565                 570                 575     

Ala Val Gly Phe Asn Tyr Ser Glu Asp Asn Tyr Lys Ala Leu Arg Ala 
            580                 585                 590         

Lys His Pro Lys Trp Leu Ile Tyr Gly Ser Glu Thr Ser Ser Ala Thr 
        595                 600                 605             

Arg Thr Arg Gly Ser Tyr Tyr Arg Pro Glu Arg Glu Leu Lys His Ser 
    610                 615                 620                 

Asn Gly Pro Glu Arg Asn Tyr Glu Gln Ser Asp Tyr Gly Asn Asp Arg 
625                 630                 635                 640 

Val Gly Trp Gly Lys Thr Ala Thr Ala Ser Trp Thr Phe Asp Arg Asp 
                645                 650                 655     

Asn Ala Gly Tyr Ala Gly Gln Phe Ile Trp Thr Gly Thr Asp Tyr Ile 
            660                 665                 670         

Gly Glu Pro Thr Pro Trp His Asn Gln Asn Gln Thr Pro Val Lys Ser 
        675                 680                 685             

Ser Tyr Phe Gly Ile Val Asp Thr Ala Gly Ile Pro Lys His Asp Phe 
    690                 695                 700                 

Tyr Leu Tyr Gln Ser Gln Trp Val Ser Val Lys Lys Lys Pro Met Val 
705                 710                 715                 720 

His Leu Leu Pro His Trp Asn Trp Glu Asn Lys Glu Leu Ala Ser Lys 
                725                 730                 735     

Val Ala Asp Ser Glu Gly Lys Ile Pro Val Arg Ala Tyr Ser Asn Ala 
            740                 745                 750         

Ser Ser Val Glu Leu Phe Leu Asn Gly Lys Ser Leu Gly Leu Lys Thr 
        755                 760                 765             

Phe Asn Lys Lys Gln Thr Ser Asp Gly Arg Thr Tyr Gln Glu Gly Ala 
    770                 775                 780                 

Asn Ala Asn Glu Leu Tyr Leu Glu Trp Lys Val Ala Tyr Gln Pro Gly 
785                 790                 795                 800 

Thr Leu Glu Ala Ile Ala Arg Asp Glu Ser Gly Lys Glu Ile Ala Arg 
                805                 810                 815     

Asp Lys Ile Thr Thr Ala Gly Lys Pro Ala Ala Val Arg Leu Ile Lys 
            820                 825                 830         

Glu Asp His Ala Ile Ala Ala Asp Gly Lys Asp Leu Thr Tyr Ile Tyr 
        835                 840                 845             

Tyr Glu Ile Val Asp Ser Gln Gly Asn Val Val Pro Thr Ala Asn Asn 
    850                 855                 860                 

Leu Val Arg Phe Gln Leu His Gly Gln Gly Gln Leu Val Gly Val Asp 
865                 870                 875                 880 

Asn Gly Glu Gln Ala Ser Arg Glu Arg Tyr Lys Ala Gln Ala Asp Gly 
                885                 890                 895     

Ser Trp Ile Arg Lys Ala Phe Asn Gly Lys Gly Val Ala Ile Val Lys 
            900                 905                 910         

Ser Thr Glu Gln Ala Gly Lys Phe Thr Leu Thr Ala His Ser Asp Leu 
        915                 920                 925             

Leu Lys Ser Asn Gln Val Thr Val Phe Thr Gly Lys Lys Glu Gly Gln 
    930                 935                 940                 

Glu Lys Thr Val Leu Gly Thr Glu Val Pro Lys Val Gln Thr Ile Ile 
945                 950                 955                 960 

Gly Glu Ala Pro Glu Met Pro Thr Thr Val Pro Phe Val Tyr Ser Asp 
                965                 970                 975     

Gly Ser Arg Ala Glu Arg Pro Val Thr Trp Ser Ser Val Asp Val Ser 
            980                 985                 990         

Lys Pro Gly Ile Val Thr Val Lys Gly Met Ala Asp Gly Arg Glu Val 
        995                 1000                1005            

Glu Ala Arg Val Glu Val Ile Ala Leu Lys Ser Glu Leu Pro Val Val 
    1010                1015                1020                

Lys Arg Ile Ala Pro Asn Thr Asp Leu Asn Ser Val Asp Lys Ser Val 
1025                1030                1035                1040

Ser Tyr Val Leu Ile Asp Gly Ser Val Glu Glu Tyr Glu Val Asp Lys 
                1045                1050                1055    

Trp Glu Ile Ala Glu Glu Asp Lys Ala Lys Gly Ser Gly Ser Gly Gly 
            1060                1065                1070        

Gly Gly Ala Glu Thr Thr Asp Asp Lys Ile Ala Ala Gln Asp Asn Lys 
        1075                1080                1085            

Ile Ser Asn Leu Thr Ala Gln Gln Gln Glu Ala Gln Lys Gln Val Asp 
    1090                1095                1100                

Gln Ile Gln Glu Gln Val Ser Ala Ile Gln Ala Glu Gln Ser Asn Leu 
1105                1110                1115                1120

Gln Ala Glu Asn Asp Arg Leu Gln Ala Glu Ser Lys Lys Leu Glu Gly 
                1125                1130                1135    

Glu Ile Thr Glu Leu Ser Lys Asn Ile Val Ser Arg Asn Gln Ser Leu 
            1140                1145                1150        

Glu Lys Gln Ala Arg Ser Ala Gln Thr Asn Gly Ala Val Thr Ser Tyr 
        1155                1160                1165            

Ile Asn Thr Ile Val Asn Ser Lys Ser Ile Thr Glu Ala Ile Ser Arg 
    1170                1175                1180                

Val Ala Ala Met Ser Glu Ile Val Ser Ala Asn Asn Lys Met Leu Glu 
1185                1190                1195                1200

Gln Gln Lys Ala Asp Lys Lys Ala Ile Ser Glu Lys Gln Val Ala Asn 
                1205                1210                1215    

Asn Asp Ala Ile Asn Thr Val Ile Ala Asn Gln Gln Lys Leu Ala Asp 
            1220                1225                1230        

Asp Ala Gln Ala Leu Thr Thr Lys Gln Ala Glu Leu Lys Ala Ala Glu 
        1235                1240                1245            

Leu Ser Leu Ala Ala Glu Lys Ala Thr Ala Glu Gly Glu Lys Ala Ser 
    1250                1255                1260                

Leu Leu Glu Gln Lys Ala Ala Ala Glu Ala Glu Ala Arg Ala Ala Ala 
1265                1270                1275                1280

Val Ala Glu Ala Ala Tyr Lys Glu Lys Arg Ala Ser Gln Gln Gln Ser 
                1285                1290                1295    

Val Leu Ala Ser Ala Asn Thr Asn Leu Thr Ala Gln Val Gln Ala Val 
            1300                1305                1310        

Ser Glu Ser Ala Ala Ala Pro Val Arg Ala Lys Val Arg Pro Thr Tyr 
        1315                1320                1325            

Ser Thr Asn Ala Ser Ser Tyr Pro Ile Gly Glu Cys Thr Trp Gly Val 
    1330                1335                1340                

Lys Thr Leu Ala Pro Trp Ala Gly Asp Tyr Trp Gly Asn Gly Ala Gln 
1345                1350                1355                1360

Trp Ala Thr Ser Ala Ala Ala Ala Gly Phe Arg Thr Gly Ser Thr Pro 
                1365                1370                1375    

Gln Val Gly Ala Ile Ala Cys Trp Asn Asp Gly Gly Tyr Gly His Val 
            1380                1385                1390        

Ala Val Val Thr Ala Val Glu Ser Thr Thr Arg Ile Gln Val Ser Glu 
        1395                1400                1405            

Ser Asn Tyr Ala Gly Asn Arg Thr Ile Gly Asn His Arg Gly Trp Phe 
    1410                1415                1420                

Asn Pro Thr Thr Thr Ser Glu Gly Phe Val Thr Tyr Ile Tyr Ala Asp 
1425                1430                1435                1440

Ala Ala Ala Leu Glu His His His His His His 
                1445                1450    

<210>   225
<211>   1486
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Hybrid polypeptide

<400>   225
Met Ala Ser Ile Ala Glu Glu Asp Lys Ala Lys Leu Ala Ile Pro Gly 
1               5                   10                  15      

Ser Arg Ile Gln Ala Thr Gly Tyr Leu Glu Gly Gln Pro Ile His Ala 
            20                  25                  30          

Thr Leu Val Val Glu Glu Gly Asn Pro Ala Ala Pro Ala Val Pro Thr 
        35                  40                  45              

Val Thr Val Gly Gly Glu Ala Val Thr Gly Leu Thr Ser Gln Lys Pro 
    50                  55                  60                  

Met Gln Tyr Arg Thr Leu Ala Tyr Gly Ala Lys Leu Pro Glu Val Thr 
65                  70                  75                  80  

Ala Ser Ala Lys Asn Ala Ala Val Thr Val Leu Gln Ala Ser Ala Ala 
                85                  90                  95      

Asn Gly Met Arg Ala Ser Ile Phe Ile Gln Pro Lys Asp Gly Gly Pro 
            100                 105                 110         

Leu Gln Thr Tyr Ala Ile Gln Phe Leu Glu Glu Ala Pro Lys Ile Ala 
        115                 120                 125             

His Leu Ser Leu Gln Val Glu Lys Ala Asp Ser Leu Lys Glu Asp Gln 
    130                 135                 140                 

Thr Val Lys Leu Ser Val Arg Ala His Tyr Gln Asp Gly Thr Gln Ala 
145                 150                 155                 160 

Val Leu Pro Ala Asp Lys Val Thr Phe Ser Thr Ser Gly Glu Gly Glu 
                165                 170                 175     

Val Ala Ile Arg Lys Gly Met Leu Glu Leu His Lys Pro Gly Ala Val 
            180                 185                 190         

Thr Leu Asn Ala Glu Tyr Glu Gly Ala Lys Asp Gln Val Glu Leu Thr 
        195                 200                 205             

Ile Gln Ala Asn Thr Glu Lys Lys Ile Ala Gln Ser Ile Arg Pro Val 
    210                 215                 220                 

Asn Val Val Thr Asp Leu His Gln Glu Pro Ser Leu Pro Ala Thr Val 
225                 230                 235                 240 

Thr Val Glu Tyr Asp Lys Gly Phe Pro Lys Thr His Lys Val Thr Trp 
                245                 250                 255     

Gln Ala Ile Pro Lys Glu Lys Leu Asp Ser Tyr Gln Thr Phe Glu Val 
            260                 265                 270         

Leu Gly Lys Val Glu Gly Ile Asp Leu Glu Ala Arg Ala Lys Val Ser 
        275                 280                 285             

Val Glu Gly Ile Val Ser Val Glu Glu Val Ser Val Thr Thr Pro Ile 
    290                 295                 300                 

Ala Glu Ala Pro Gln Leu Pro Glu Ser Val Arg Thr Tyr Asp Ser Asn 
305                 310                 315                 320 

Gly His Val Ser Ser Ala Lys Val Ala Trp Asp Ala Ile Arg Pro Glu 
                325                 330                 335     

Gln Tyr Ala Lys Glu Gly Val Phe Thr Val Asn Gly Arg Leu Glu Gly 
            340                 345                 350         

Thr Gln Leu Thr Thr Lys Leu His Val Arg Val Ser Ala Gln Thr Glu 
        355                 360                 365             

Gln Gly Ala Asn Ile Ser Asp Gln Trp Thr Gly Ser Glu Leu Pro Leu 
    370                 375                 380                 

Ala Phe Ala Ser Asp Ser Asn Pro Ser Asp Pro Val Ser Asn Val Asn 
385                 390                 395                 400 

Asp Lys Leu Ile Ser Tyr Asn Asn Gln Pro Ala Asn Arg Trp Thr Asn 
                405                 410                 415     

Trp Asn Arg Thr Asn Pro Glu Ala Ser Val Gly Val Leu Phe Gly Asp 
            420                 425                 430         

Ser Gly Ile Leu Ser Lys Arg Ser Val Asp Asn Leu Ser Val Gly Phe 
        435                 440                 445             

His Glu Asp His Gly Val Gly Val Pro Lys Ser Tyr Val Ile Glu Tyr 
    450                 455                 460                 

Tyr Val Gly Lys Thr Val Pro Thr Ala Pro Lys Asn Pro Ser Phe Val 
465                 470                 475                 480 

Gly Asn Glu Asp His Val Phe Asn Asp Ser Ala Asn Trp Lys Pro Val 
                485                 490                 495     

Thr Asn Leu Lys Ala Pro Ala Gln Leu Lys Ala Gly Glu Met Asn His 
            500                 505                 510         

Phe Ser Phe Asp Lys Val Glu Thr Tyr Ala Val Arg Ile Arg Met Val 
        515                 520                 525             

Lys Ala Asp Asn Lys Arg Gly Thr Ser Ile Thr Glu Val Gln Ile Phe 
    530                 535                 540                 

Ala Lys Gln Val Ala Ala Ala Lys Gln Gly Gln Thr Arg Ile Gln Val 
545                 550                 555                 560 

Asp Gly Lys Asp Leu Ala Asn Phe Asn Pro Asp Leu Thr Asp Tyr Tyr 
                565                 570                 575     

Leu Glu Ser Val Asp Gly Lys Val Pro Ala Val Thr Ala Ser Val Ser 
            580                 585                 590         

Asn Asn Gly Leu Ala Thr Val Val Pro Ser Val Arg Glu Gly Glu Pro 
        595                 600                 605             

Val Arg Val Ile Ala Lys Ala Glu Asn Gly Asp Ile Leu Gly Glu Tyr 
    610                 615                 620                 

Arg Leu His Phe Thr Lys Asp Lys Ser Leu Leu Ser His Lys Pro Val 
625                 630                 635                 640 

Ala Ala Val Lys Gln Ala Arg Leu Leu Gln Val Gly Gln Ala Leu Glu 
                645                 650                 655     

Leu Pro Thr Lys Val Pro Val Tyr Phe Thr Gly Lys Asp Gly Tyr Glu 
            660                 665                 670         

Thr Lys Asp Leu Thr Val Glu Trp Glu Glu Val Pro Ala Glu Asn Leu 
        675                 680                 685             

Thr Lys Ala Gly Gln Phe Thr Val Arg Gly Arg Val Leu Gly Ser Asn 
    690                 695                 700                 

Leu Val Ala Glu Ile Thr Val Arg Val Thr Asp Lys Leu Gly Glu Thr 
705                 710                 715                 720 

Leu Ser Asp Asn Pro Asn Tyr Asp Glu Asn Ser Asn Gln Ala Phe Ala 
                725                 730                 735     

Ser Ala Thr Asn Asp Ile Asp Lys Asn Ser His Asp Arg Val Asp Tyr 
            740                 745                 750         

Leu Asn Asp Gly Asp His Ser Glu Asn Arg Arg Trp Thr Asn Trp Ser 
        755                 760                 765             

Pro Thr Pro Ser Ser Asn Pro Glu Val Ser Ala Gly Val Ile Phe Arg 
    770                 775                 780                 

Glu Asn Gly Lys Ile Val Glu Arg Thr Val Thr Gln Gly Lys Val Gln 
785                 790                 795                 800 

Phe Phe Ala Asp Ser Gly Thr Asp Ala Pro Ser Lys Leu Val Leu Glu 
                805                 810                 815     

Arg Tyr Val Gly Pro Glu Phe Glu Val Pro Thr Tyr Tyr Ser Asn Tyr 
            820                 825                 830         

Gln Ala Tyr Asp Ala Asp His Pro Phe Asn Asn Pro Glu Asn Trp Glu 
        835                 840                 845             

Ala Val Pro Tyr Arg Ala Asp Lys Asp Ile Ala Ala Gly Asp Glu Ile 
    850                 855                 860                 

Asn Val Thr Phe Lys Ala Ile Lys Ala Lys Ala Met Arg Trp Arg Met 
865                 870                 875                 880 

Glu Arg Lys Ala Asp Lys Ser Gly Val Ala Met Ile Glu Met Thr Phe 
                885                 890                 895     

Leu Ala Pro Ser Glu Leu Pro Gln Glu Ser Thr Gln Ser Lys Ile Leu 
            900                 905                 910         

Val Asp Gly Lys Glu Leu Ala Asp Phe Ala Glu Asn Arg Gln Asp Tyr 
        915                 920                 925             

Gln Ile Thr Tyr Lys Gly Gln Arg Pro Lys Val Ser Val Glu Glu Asn 
    930                 935                 940                 

Asn Gln Val Ala Ser Thr Val Val Asp Ser Gly Glu Asp Ser Phe Pro 
945                 950                 955                 960 

Val Leu Val Arg Leu Val Ser Glu Ser Gly Lys Gln Val Lys Glu Tyr 
                965                 970                 975     

Arg Ile His Leu Thr Lys Glu Lys Pro Val Ser Glu Lys Thr Val Ala 
            980                 985                 990         

Ala Val Gln Glu Asp Leu Pro Lys Ile Glu Phe Val Glu Lys Asp Leu 
        995                 1000                1005            

Ala Tyr Lys Thr Val Glu Lys Lys Asp Ser Thr Leu Tyr Leu Gly Glu 
    1010                1015                1020                

Thr Arg Val Glu Gln Glu Gly Lys Val Gly Lys Glu Arg Ile Phe Thr 
1025                1030                1035                1040

Ala Ile Asn Pro Asp Gly Ser Lys Glu Glu Lys Leu Arg Glu Val Val 
                1045                1050                1055    

Glu Val Pro Thr Asp Arg Ile Val Leu Val Gly Thr Lys Pro Val Ala 
            1060                1065                1070        

Gln Glu Ala Lys Lys Pro Gln Val Ser Glu Lys Ala Asp Thr Lys Pro 
        1075                1080                1085            

Ile Asp Ser Ser Glu Ala Ser Gln Thr Asn Lys Ala Gln Gly Ser Gly 
    1090                1095                1100                

Ser Gly Gly Gly Gly Ala Glu Thr Thr Asp Asp Lys Ile Ala Ala Gln 
1105                1110                1115                1120

Asp Asn Lys Ile Ser Asn Leu Thr Ala Gln Gln Gln Glu Ala Gln Lys 
                1125                1130                1135    

Gln Val Asp Gln Ile Gln Glu Gln Val Ser Ala Ile Gln Ala Glu Gln 
            1140                1145                1150        

Ser Asn Leu Gln Ala Glu Asn Asp Arg Leu Gln Ala Glu Ser Lys Lys 
        1155                1160                1165            

Leu Glu Gly Glu Ile Thr Glu Leu Ser Lys Asn Ile Val Ser Arg Asn 
    1170                1175                1180                

Gln Ser Leu Glu Lys Gln Ala Arg Ser Ala Gln Thr Asn Gly Ala Val 
1185                1190                1195                1200

Thr Ser Tyr Ile Asn Thr Ile Val Asn Ser Lys Ser Ile Thr Glu Ala 
                1205                1210                1215    

Ile Ser Arg Val Ala Ala Met Ser Glu Ile Val Ser Ala Asn Asn Lys 
            1220                1225                1230        

Met Leu Glu Gln Gln Lys Ala Asp Lys Lys Ala Ile Ser Glu Lys Gln 
        1235                1240                1245            

Val Ala Asn Asn Asp Ala Ile Asn Thr Val Ile Ala Asn Gln Gln Lys 
    1250                1255                1260                

Leu Ala Asp Asp Ala Gln Ala Leu Thr Thr Lys Gln Ala Glu Leu Lys 
1265                1270                1275                1280

Ala Ala Glu Leu Ser Leu Ala Ala Glu Lys Ala Thr Ala Glu Gly Glu 
                1285                1290                1295    

Lys Ala Ser Leu Leu Glu Gln Lys Ala Ala Ala Glu Ala Glu Ala Arg 
            1300                1305                1310        

Ala Ala Ala Val Ala Glu Ala Ala Tyr Lys Glu Lys Arg Ala Ser Gln 
        1315                1320                1325            

Gln Gln Ser Val Leu Ala Ser Ala Asn Thr Asn Leu Thr Ala Gln Val 
    1330                1335                1340                

Gln Ala Val Ser Glu Ser Ala Ala Ala Pro Val Arg Ala Lys Val Arg 
1345                1350                1355                1360

Pro Thr Tyr Ser Thr Asn Ala Ser Ser Tyr Pro Ile Gly Glu Cys Thr 
                1365                1370                1375    

Trp Gly Val Lys Thr Leu Ala Pro Trp Ala Gly Asp Tyr Trp Gly Asn 
            1380                1385                1390        

Gly Ala Gln Trp Ala Thr Ser Ala Ala Ala Ala Gly Phe Arg Thr Gly 
        1395                1400                1405            

Ser Thr Pro Gln Val Gly Ala Ile Ala Cys Trp Asn Asp Gly Gly Tyr 
    1410                1415                1420                

Gly His Val Ala Val Val Thr Ala Val Glu Ser Thr Thr Arg Ile Gln 
1425                1430                1435                1440

Val Ser Glu Ser Asn Tyr Ala Gly Asn Arg Thr Ile Gly Asn His Arg 
                1445                1450                1455    

Gly Trp Phe Asn Pro Thr Thr Thr Ser Glu Gly Phe Val Thr Tyr Ile 
            1460                1465                1470        

Tyr Ala Asp Ala Ala Ala Leu Glu His His His His His His 
        1475                1480                1485    

<210>   226
<211>   2996
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Hybrid polypeptide

<400>   226
Met Ala Ser Asp Glu Thr Leu Ile Thr His Thr Ala Glu Lys Pro Lys 
1               5                   10                  15      

Glu Glu Lys Met Ile Val Glu Glu Lys Ala Asp Lys Ala Leu Glu Thr 
            20                  25                  30          

Lys Asn Ile Val Glu Arg Thr Glu Gln Ser Glu Pro Ser Ser Thr Glu 
        35                  40                  45              

Ala Ile Ala Ser Glu Lys Lys Glu Asp Glu Ala Val Thr Pro Lys Glu 
    50                  55                  60                  

Glu Lys Val Ser Ala Lys Pro Glu Glu Lys Ala Pro Arg Ile Glu Ser 
65                  70                  75                  80  

Gln Ala Ser Asn Gln Glu Lys Pro Leu Lys Glu Asp Ala Lys Ala Val 
                85                  90                  95      

Thr Asn Glu Glu Val Asn Gln Met Ile Glu Asp Arg Lys Val Asp Phe 
            100                 105                 110         

Asn Gln Asn Trp Tyr Phe Lys Leu Asn Ala Asn Ser Lys Glu Ala Ile 
        115                 120                 125             

Lys Pro Asp Ala Asp Val Ser Thr Trp Lys Lys Leu Asp Leu Pro Tyr 
    130                 135                 140                 

Asp Trp Ser Ile Phe Asn Asp Phe Asp His Glu Ser Pro Ala Gln Asn 
145                 150                 155                 160 

Glu Gly Gly Gln Leu Asn Gly Gly Glu Ala Trp Tyr Arg Lys Thr Phe 
                165                 170                 175     

Lys Leu Asp Glu Lys Asp Leu Lys Lys Asn Val Arg Leu Thr Phe Asp 
            180                 185                 190         

Gly Val Tyr Met Asp Ser Gln Val Tyr Val Asn Gly Gln Leu Val Gly 
        195                 200                 205             

His Tyr Pro Asn Gly Tyr Asn Gln Phe Ser Tyr Asp Ile Thr Lys Tyr 
    210                 215                 220                 

Leu Gln Lys Asp Gly Arg Glu Asn Val Ile Ala Val His Ala Val Asn 
225                 230                 235                 240 

Lys Gln Pro Ser Ser Arg Trp Tyr Ser Gly Ser Gly Ile Tyr Arg Asp 
                245                 250                 255     

Val Thr Leu Gln Val Thr Asp Lys Val His Val Glu Lys Asn Gly Thr 
            260                 265                 270         

Thr Ile Leu Thr Pro Lys Leu Glu Glu Gln Gln His Gly Lys Val Glu 
        275                 280                 285             

Thr His Val Thr Ser Lys Ile Val Asn Thr Asp Asp Lys Asp His Glu 
    290                 295                 300                 

Leu Val Ala Glu Tyr Gln Ile Val Glu Arg Gly Gly His Ala Val Thr 
305                 310                 315                 320 

Gly Leu Val Arg Thr Ala Ser Arg Thr Leu Lys Ala His Glu Ser Thr 
                325                 330                 335     

Ser Leu Asp Ala Ile Leu Glu Val Glu Arg Pro Lys Leu Trp Thr Val 
            340                 345                 350         

Leu Asn Asp Lys Pro Ala Leu Tyr Glu Leu Ile Thr Arg Val Tyr Arg 
        355                 360                 365             

Asp Gly Gln Leu Val Asp Ala Lys Lys Asp Leu Phe Gly Tyr Arg Tyr 
    370                 375                 380                 

Tyr His Trp Thr Pro Asn Glu Gly Phe Ser Leu Asn Gly Glu Arg Ile 
385                 390                 395                 400 

Lys Phe His Gly Val Ser Leu His His Asp His Gly Ala Leu Gly Ala 
                405                 410                 415     

Glu Glu Asn Tyr Lys Ala Glu Tyr Arg Arg Leu Lys Gln Met Lys Glu 
            420                 425                 430         

Met Gly Val Asn Ser Ile Arg Thr Thr His Asn Pro Ala Ser Glu Gln 
        435                 440                 445             

Thr Leu Gln Ile Ala Ala Glu Leu Gly Leu Leu Val Gln Glu Glu Ala 
    450                 455                 460                 

Phe Asp Thr Trp Tyr Gly Gly Lys Lys Pro Tyr Asp Tyr Gly Arg Phe 
465                 470                 475                 480 

Phe Glu Lys Asp Ala Thr His Pro Glu Ala Arg Lys Gly Glu Lys Trp 
                485                 490                 495     

Ser Asp Phe Asp Leu Arg Thr Met Val Glu Arg Gly Lys Asn Asn Pro 
            500                 505                 510         

Ala Ile Phe Met Trp Ser Ile Gly Asn Glu Ile Gly Glu Ala Asn Gly 
        515                 520                 525             

Asp Ala His Ser Leu Ala Thr Val Lys Arg Leu Val Lys Val Ile Lys 
    530                 535                 540                 

Asp Val Asp Lys Thr Arg Tyr Val Thr Met Gly Ala Asp Lys Phe Arg 
545                 550                 555                 560 

Phe Gly Asn Gly Ser Gly Gly His Glu Lys Ile Ala Asp Glu Leu Asp 
                565                 570                 575     

Ala Val Gly Phe Asn Tyr Ser Glu Asp Asn Tyr Lys Ala Leu Arg Ala 
            580                 585                 590         

Lys His Pro Lys Trp Leu Ile Tyr Gly Ser Glu Thr Ser Ser Ala Thr 
        595                 600                 605             

Arg Thr Arg Gly Ser Tyr Tyr Arg Pro Glu Arg Glu Leu Lys His Ser 
    610                 615                 620                 

Asn Gly Pro Glu Arg Asn Tyr Glu Gln Ser Asp Tyr Gly Asn Asp Arg 
625                 630                 635                 640 

Val Gly Trp Gly Lys Thr Ala Thr Ala Ser Trp Thr Phe Asp Arg Asp 
                645                 650                 655     

Asn Ala Gly Tyr Ala Gly Gln Phe Ile Trp Thr Gly Thr Asp Tyr Ile 
            660                 665                 670         

Gly Glu Pro Thr Pro Trp His Asn Gln Asn Gln Thr Pro Val Lys Ser 
        675                 680                 685             

Ser Tyr Phe Gly Ile Val Asp Thr Ala Gly Ile Pro Lys His Asp Phe 
    690                 695                 700                 

Tyr Leu Tyr Gln Ser Gln Trp Val Ser Val Lys Lys Lys Pro Met Val 
705                 710                 715                 720 

His Leu Leu Pro His Trp Asn Trp Glu Asn Lys Glu Leu Ala Ser Lys 
                725                 730                 735     

Val Ala Asp Ser Glu Gly Lys Ile Pro Val Arg Ala Tyr Ser Asn Ala 
            740                 745                 750         

Ser Ser Val Glu Leu Phe Leu Asn Gly Lys Ser Leu Gly Leu Lys Thr 
        755                 760                 765             

Phe Asn Lys Lys Gln Thr Ser Asp Gly Arg Thr Tyr Gln Glu Gly Ala 
    770                 775                 780                 

Asn Ala Asn Glu Leu Tyr Leu Glu Trp Lys Val Ala Tyr Gln Pro Gly 
785                 790                 795                 800 

Thr Leu Glu Ala Ile Ala Arg Asp Glu Ser Gly Lys Glu Ile Ala Arg 
                805                 810                 815     

Asp Lys Ile Thr Thr Ala Gly Lys Pro Ala Ala Val Arg Leu Ile Lys 
            820                 825                 830         

Glu Asp His Ala Ile Ala Ala Asp Gly Lys Asp Leu Thr Tyr Ile Tyr 
        835                 840                 845             

Tyr Glu Ile Val Asp Ser Gln Gly Asn Val Val Pro Thr Ala Asn Asn 
    850                 855                 860                 

Leu Val Arg Phe Gln Leu His Gly Gln Gly Gln Leu Val Gly Val Asp 
865                 870                 875                 880 

Asn Gly Glu Gln Ala Ser Arg Glu Arg Tyr Lys Ala Gln Ala Asp Gly 
                885                 890                 895     

Ser Trp Ile Arg Lys Ala Phe Asn Gly Lys Gly Val Ala Ile Val Lys 
            900                 905                 910         

Ser Thr Glu Gln Ala Gly Lys Phe Thr Leu Thr Ala His Ser Asp Leu 
        915                 920                 925             

Leu Lys Ser Asn Gln Val Thr Val Phe Thr Gly Lys Lys Glu Gly Gln 
    930                 935                 940                 

Glu Lys Thr Val Leu Gly Thr Glu Val Pro Lys Val Gln Thr Ile Ile 
945                 950                 955                 960 

Gly Glu Ala Pro Glu Met Pro Thr Thr Val Pro Phe Val Tyr Ser Asp 
                965                 970                 975     

Gly Ser Arg Ala Glu Arg Pro Val Thr Trp Ser Ser Val Asp Val Ser 
            980                 985                 990         

Lys Pro Gly Ile Val Thr Val Lys Gly Met Ala Asp Gly Arg Glu Val 
        995                 1000                1005            

Glu Ala Arg Val Glu Val Ile Ala Leu Lys Ser Glu Leu Pro Val Val 
    1010                1015                1020                

Lys Arg Ile Ala Pro Asn Thr Asp Leu Asn Ser Val Asp Lys Ser Val 
1025                1030                1035                1040

Ser Tyr Val Leu Ile Asp Gly Ser Val Glu Glu Tyr Glu Val Asp Lys 
                1045                1050                1055    

Trp Glu Ile Ala Glu Glu Asp Lys Ala Lys Leu Ala Ile Pro Gly Ser 
            1060                1065                1070        

Arg Ile Gln Ala Thr Gly Tyr Leu Glu Gly Gln Pro Ile His Ala Thr 
        1075                1080                1085            

Leu Val Val Glu Glu Gly Asn Pro Ala Ala Pro Ala Val Pro Thr Val 
    1090                1095                1100                

Thr Val Gly Gly Glu Ala Val Thr Gly Leu Thr Ser Gln Lys Pro Met 
1105                1110                1115                1120

Gln Tyr Arg Thr Leu Ala Tyr Gly Ala Lys Leu Pro Glu Val Thr Ala 
                1125                1130                1135    

Ser Ala Lys Asn Ala Ala Val Thr Val Leu Gln Ala Ser Ala Ala Asn 
            1140                1145                1150        

Gly Met Arg Ala Ser Ile Phe Ile Gln Pro Lys Asp Gly Gly Pro Leu 
        1155                1160                1165            

Gln Thr Tyr Ala Ile Gln Phe Leu Glu Glu Ala Pro Lys Ile Ala His 
    1170                1175                1180                

Leu Ser Leu Gln Val Glu Lys Ala Asp Ser Leu Lys Glu Asp Gln Thr 
1185                1190                1195                1200

Val Lys Leu Ser Val Arg Ala His Tyr Gln Asp Gly Thr Gln Ala Val 
                1205                1210                1215    

Leu Pro Ala Asp Lys Val Thr Phe Ser Thr Ser Gly Glu Gly Glu Val 
            1220                1225                1230        

Ala Ile Arg Lys Gly Met Leu Glu Leu His Lys Pro Gly Ala Val Thr 
        1235                1240                1245            

Leu Asn Ala Glu Tyr Glu Gly Ala Lys Asp Gln Val Glu Leu Thr Ile 
    1250                1255                1260                

Gln Ala Asn Thr Glu Lys Lys Ile Ala Gln Ser Ile Arg Pro Val Asn 
1265                1270                1275                1280

Val Val Thr Asp Leu His Gln Glu Pro Ser Leu Pro Ala Thr Val Thr 
                1285                1290                1295    

Val Glu Tyr Asp Lys Gly Phe Pro Lys Thr His Lys Val Thr Trp Gln 
            1300                1305                1310        

Ala Ile Pro Lys Glu Lys Leu Asp Ser Tyr Gln Thr Phe Glu Val Leu 
        1315                1320                1325            

Gly Lys Val Glu Gly Ile Asp Leu Glu Ala Arg Ala Lys Val Ser Val 
    1330                1335                1340                

Glu Gly Ile Val Ser Val Glu Glu Val Ser Val Thr Thr Pro Ile Ala 
1345                1350                1355                1360

Glu Ala Pro Gln Leu Pro Glu Ser Val Arg Thr Tyr Asp Ser Asn Gly 
                1365                1370                1375    

His Val Ser Ser Ala Lys Val Ala Trp Asp Ala Ile Arg Pro Glu Gln 
            1380                1385                1390        

Tyr Ala Lys Glu Gly Val Phe Thr Val Asn Gly Arg Leu Glu Gly Thr 
        1395                1400                1405            

Gln Leu Thr Thr Lys Leu His Val Arg Val Ser Ala Gln Thr Glu Gln 
    1410                1415                1420                

Gly Ala Asn Ile Ser Asp Gln Trp Thr Gly Ser Glu Leu Pro Leu Ala 
1425                1430                1435                1440

Phe Ala Ser Asp Ser Asn Pro Ser Asp Pro Val Ser Asn Val Asn Asp 
                1445                1450                1455    

Lys Leu Ile Ser Tyr Asn Asn Gln Pro Ala Asn Arg Trp Thr Asn Trp 
            1460                1465                1470        

Asn Arg Thr Asn Pro Glu Ala Ser Val Gly Val Leu Phe Gly Asp Ser 
        1475                1480                1485            

Gly Ile Leu Ser Lys Arg Ser Val Asp Asn Leu Ser Val Gly Phe His 
    1490                1495                1500                

Glu Asp His Gly Val Gly Val Pro Lys Ser Tyr Val Ile Glu Tyr Tyr 
1505                1510                1515                1520

Val Gly Lys Thr Val Pro Thr Ala Pro Lys Asn Pro Ser Phe Val Gly 
                1525                1530                1535    

Asn Glu Asp His Val Phe Asn Asp Ser Ala Asn Trp Lys Pro Val Thr 
            1540                1545                1550        

Asn Leu Lys Ala Pro Ala Gln Leu Lys Ala Gly Glu Met Asn His Phe 
        1555                1560                1565            

Ser Phe Asp Lys Val Glu Thr Tyr Ala Val Arg Ile Arg Met Val Lys 
    1570                1575                1580                

Ala Asp Asn Lys Arg Gly Thr Ser Ile Thr Glu Val Gln Ile Phe Ala 
1585                1590                1595                1600

Lys Gln Val Ala Ala Ala Lys Gln Gly Gln Thr Arg Ile Gln Val Asp 
                1605                1610                1615    

Gly Lys Asp Leu Ala Asn Phe Asn Pro Asp Leu Thr Asp Tyr Tyr Leu 
            1620                1625                1630        

Glu Ser Val Asp Gly Lys Val Pro Ala Val Thr Ala Ser Val Ser Asn 
        1635                1640                1645            

Asn Gly Leu Ala Thr Val Val Pro Ser Val Arg Glu Gly Glu Pro Val 
    1650                1655                1660                

Arg Val Ile Ala Lys Ala Glu Asn Gly Asp Ile Leu Gly Glu Tyr Arg 
1665                1670                1675                1680

Leu His Phe Thr Lys Asp Lys Ser Leu Leu Ser His Lys Pro Val Ala 
                1685                1690                1695    

Ala Val Lys Gln Ala Arg Leu Leu Gln Val Gly Gln Ala Leu Glu Leu 
            1700                1705                1710        

Pro Thr Lys Val Pro Val Tyr Phe Thr Gly Lys Asp Gly Tyr Glu Thr 
        1715                1720                1725            

Lys Asp Leu Thr Val Glu Trp Glu Glu Val Pro Ala Glu Asn Leu Thr 
    1730                1735                1740                

Lys Ala Gly Gln Phe Thr Val Arg Gly Arg Val Leu Gly Ser Asn Leu 
1745                1750                1755                1760

Val Ala Glu Ile Thr Val Arg Val Thr Asp Lys Leu Gly Glu Thr Leu 
                1765                1770                1775    

Ser Asp Asn Pro Asn Tyr Asp Glu Asn Ser Asn Gln Ala Phe Ala Ser 
            1780                1785                1790        

Ala Thr Asn Asp Ile Asp Lys Asn Ser His Asp Arg Val Asp Tyr Leu 
        1795                1800                1805            

Asn Asp Gly Asp His Ser Glu Asn Arg Arg Trp Thr Asn Trp Ser Pro 
    1810                1815                1820                

Thr Pro Ser Ser Asn Pro Glu Val Ser Ala Gly Val Ile Phe Arg Glu 
1825                1830                1835                1840

Asn Gly Lys Ile Val Glu Arg Thr Val Thr Gln Gly Lys Val Gln Phe 
                1845                1850                1855    

Phe Ala Asp Ser Gly Thr Asp Ala Pro Ser Lys Leu Val Leu Glu Arg 
            1860                1865                1870        

Tyr Val Gly Pro Glu Phe Glu Val Pro Thr Tyr Tyr Ser Asn Tyr Gln 
        1875                1880                1885            

Ala Tyr Asp Ala Asp His Pro Phe Asn Asn Pro Glu Asn Trp Glu Ala 
    1890                1895                1900                

Val Pro Tyr Arg Ala Asp Lys Asp Ile Ala Ala Gly Asp Glu Ile Asn 
1905                1910                1915                1920

Val Thr Phe Lys Ala Ile Lys Ala Lys Ala Met Arg Trp Arg Met Glu 
                1925                1930                1935    

Arg Lys Ala Asp Lys Ser Gly Val Ala Met Ile Glu Met Thr Phe Leu 
            1940                1945                1950        

Ala Pro Ser Glu Leu Pro Gln Glu Ser Thr Gln Ser Lys Ile Leu Val 
        1955                1960                1965            

Asp Gly Lys Glu Leu Ala Asp Phe Ala Glu Asn Arg Gln Asp Tyr Gln 
    1970                1975                1980                

Ile Thr Tyr Lys Gly Gln Arg Pro Lys Val Ser Val Glu Glu Asn Asn 
1985                1990                1995                2000

Gln Val Ala Ser Thr Val Val Asp Ser Gly Glu Asp Ser Phe Pro Val 
                2005                2010                2015    

Leu Val Arg Leu Val Ser Glu Ser Gly Lys Gln Val Lys Glu Tyr Arg 
            2020                2025                2030        

Ile His Leu Thr Lys Glu Lys Pro Val Ser Glu Lys Thr Val Ala Ala 
        2035                2040                2045            

Val Gln Glu Asp Leu Pro Lys Ile Glu Phe Val Glu Lys Asp Leu Ala 
    2050                2055                2060                

Tyr Lys Thr Val Glu Lys Lys Asp Ser Thr Leu Tyr Leu Gly Glu Thr 
2065                2070                2075                2080

Arg Val Glu Gln Glu Gly Lys Val Gly Lys Glu Arg Ile Phe Thr Ala 
                2085                2090                2095    

Ile Asn Pro Asp Gly Ser Lys Glu Glu Lys Leu Arg Glu Val Val Glu 
            2100                2105                2110        

Val Pro Thr Asp Arg Ile Val Leu Val Gly Thr Lys Pro Val Ala Gln 
        2115                2120                2125            

Glu Ala Lys Lys Pro Gln Val Ser Glu Lys Ala Asp Thr Lys Pro Ile 
    2130                2135                2140                

Asp Ser Ser Glu Ala Ser Gln Thr Asn Lys Ala Gln Gly Ser Gly Ser 
2145                2150                2155                2160

Gly Gly Gly Gly Glu Thr Pro Glu Thr Ser Pro Ala Ile Gly Lys Val 
                2165                2170                2175    

Val Ile Lys Glu Thr Gly Glu Gly Gly Ala Leu Leu Gly Asp Ala Val 
            2180                2185                2190        

Phe Glu Leu Lys Asn Asn Thr Asp Gly Thr Thr Val Ser Gln Arg Thr 
        2195                2200                2205            

Glu Ala Gln Thr Gly Glu Ala Ile Phe Ser Asn Ile Lys Pro Gly Thr 
    2210                2215                2220                

Tyr Thr Leu Thr Glu Ala Gln Pro Pro Val Gly Tyr Lys Pro Ser Thr 
2225                2230                2235                2240

Lys Gln Trp Thr Val Glu Val Glu Lys Asn Gly Arg Thr Thr Val Gln 
                2245                2250                2255    

Gly Glu Gln Val Glu Asn Arg Glu Glu Ala Leu Ser Asp Gln Tyr Pro 
            2260                2265                2270        

Gln Thr Gly Thr Tyr Pro Asp Val Gln Thr Pro Tyr Gln Ile Ile Lys 
        2275                2280                2285            

Val Asp Gly Ser Glu Lys Asn Gly Gln His Lys Ala Leu Asn Pro Asn 
    2290                2295                2300                

Pro Tyr Glu Arg Val Ile Pro Glu Gly Thr Leu Ser Lys Arg Ile Tyr 
2305                2310                2315                2320

Gln Val Asn Asn Leu Asp Asp Asn Gln Tyr Gly Ile Glu Leu Thr Val 
                2325                2330                2335    

Ser Gly Lys Thr Val Tyr Glu Gln Lys Asp Lys Ser Val Pro Leu Asp 
            2340                2345                2350        

Val Val Ile Leu Leu Asp Asn Ser Asn Ser Met Ser Asn Ile Arg Asn 
        2355                2360                2365            

Lys Asn Ala Arg Arg Ala Glu Arg Ala Gly Glu Ala Thr Arg Ser Leu 
    2370                2375                2380                

Ile Asp Lys Ile Thr Ser Asp Ser Glu Asn Arg Val Ala Leu Val Thr 
2385                2390                2395                2400

Tyr Ala Ser Thr Ile Phe Asp Gly Thr Glu Phe Thr Val Glu Lys Gly 
                2405                2410                2415    

Val Ala Asp Lys Asn Gly Lys Arg Leu Asn Asp Ser Leu Phe Trp Asn 
            2420                2425                2430        

Tyr Asp Gln Thr Ser Phe Thr Thr Asn Thr Lys Asp Tyr Ser Tyr Leu 
        2435                2440                2445            

Lys Leu Thr Asn Asp Lys Asn Asp Ile Val Glu Leu Lys Asn Lys Val 
    2450                2455                2460                

Pro Thr Glu Ala Glu Asp His Asp Gly Asn Arg Leu Met Tyr Gln Phe 
2465                2470                2475                2480

Gly Ala Thr Phe Thr Gln Lys Ala Leu Met Lys Ala Asp Glu Ile Leu 
                2485                2490                2495    

Thr Gln Gln Ala Arg Gln Asn Ser Gln Lys Val Ile Phe His Ile Thr 
            2500                2505                2510        

Asp Gly Val Pro Thr Met Ser Tyr Pro Ile Asn Phe Asn His Ala Thr 
        2515                2520                2525            

Phe Ala Pro Ser Tyr Gln Asn Gln Leu Asn Ala Phe Phe Ser Lys Ser 
    2530                2535                2540                

Pro Asn Lys Asp Gly Ile Leu Leu Ser Asp Phe Ile Thr Gln Ala Thr 
2545                2550                2555                2560

Ser Gly Glu His Thr Ile Val Arg Gly Asp Gly Gln Ser Tyr Gln Met 
                2565                2570                2575    

Phe Thr Asp Lys Thr Val Tyr Glu Lys Gly Ala Pro Ala Ala Phe Pro 
            2580                2585                2590        

Val Lys Pro Glu Lys Tyr Ser Glu Met Lys Ala Ala Gly Tyr Ala Val 
        2595                2600                2605            

Ile Gly Asp Pro Ile Asn Gly Gly Tyr Ile Trp Leu Asn Trp Arg Glu 
    2610                2615                2620                

Ser Ile Leu Ala Tyr Pro Phe Asn Ser Asn Thr Ala Lys Ile Thr Asn 
2625                2630                2635                2640

His Gly Asp Pro Thr Arg Trp Tyr Tyr Asn Gly Asn Ile Ala Pro Asp 
                2645                2650                2655    

Gly Tyr Asp Val Phe Thr Val Gly Ile Gly Ile Asn Gly Asp Pro Gly 
            2660                2665                2670        

Thr Asp Glu Ala Thr Ala Thr Ser Phe Met Gln Ser Ile Ser Ser Lys 
        2675                2680                2685            

Pro Glu Asn Tyr Thr Asn Val Thr Asp Thr Thr Lys Ile Leu Glu Gln 
    2690                2695                2700                

Leu Asn Arg Tyr Phe His Thr Ile Val Thr Glu Lys Lys Ser Ile Glu 
2705                2710                2715                2720

Asn Gly Thr Ile Thr Asp Pro Met Gly Glu Leu Ile Asp Leu Gln Leu 
                2725                2730                2735    

Gly Thr Asp Gly Arg Phe Asp Pro Ala Asp Tyr Thr Leu Thr Ala Asn 
            2740                2745                2750        

Asp Gly Ser Arg Leu Glu Asn Gly Gln Ala Val Gly Gly Pro Gln Asn 
        2755                2760                2765            

Asp Gly Gly Leu Leu Lys Asn Ala Lys Val Leu Tyr Asp Thr Thr Glu 
    2770                2775                2780                

Lys Arg Ile Arg Val Thr Gly Leu Tyr Leu Gly Thr Asp Glu Lys Val 
2785                2790                2795                2800

Thr Leu Thr Tyr Asn Val Arg Leu Asn Asp Glu Phe Val Ser Asn Lys 
                2805                2810                2815    

Phe Tyr Asp Thr Asn Gly Arg Thr Thr Leu His Pro Lys Glu Val Glu 
            2820                2825                2830        

Gln Asn Thr Val Arg Asp Phe Pro Ile Pro Lys Ile Arg Asp Val Arg 
        2835                2840                2845            

Lys Tyr Pro Glu Ile Thr Ile Ser Lys Glu Lys Lys Leu Gly Asp Ile 
    2850                2855                2860                

Glu Phe Ile Lys Val Asn Lys Asn Asp Lys Lys Pro Leu Arg Gly Ala 
2865                2870                2875                2880

Val Phe Ser Leu Gln Lys Gln His Pro Asp Tyr Pro Asp Ile Tyr Gly 
                2885                2890                2895    

Ala Ile Asp Gln Asn Gly Thr Tyr Gln Asn Val Arg Thr Gly Glu Asp 
            2900                2905                2910        

Gly Lys Leu Thr Phe Lys Asn Leu Ser Asp Gly Lys Tyr Arg Leu Phe 
        2915                2920                2925            

Glu Asn Ser Glu Pro Ala Gly Tyr Lys Pro Val Gln Asn Lys Pro Ile 
    2930                2935                2940                

Val Ala Phe Gln Ile Val Asn Gly Glu Val Arg Asp Val Thr Ser Ile 
2945                2950                2955                2960

Val Pro Gln Asp Ile Pro Ala Gly Tyr Glu Phe Thr Asn Asp Lys His 
                2965                2970                2975    

Tyr Ile Thr Asn Glu Pro Ile Pro Pro Lys Arg Glu Leu Glu His His 
            2980                2985                2990        

His His His His 
        2995    

<210>   227
<211>   1906
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Hybrid polypeptide

<400>   227
Met Ala Ser Asp Glu Thr Leu Ile Thr His Thr Ala Glu Lys Pro Lys 
1               5                   10                  15      

Glu Glu Lys Met Ile Val Glu Glu Lys Ala Asp Lys Ala Leu Glu Thr 
            20                  25                  30          

Lys Asn Ile Val Glu Arg Thr Glu Gln Ser Glu Pro Ser Ser Thr Glu 
        35                  40                  45              

Ala Ile Ala Ser Glu Lys Lys Glu Asp Glu Ala Val Thr Pro Lys Glu 
    50                  55                  60                  

Glu Lys Val Ser Ala Lys Pro Glu Glu Lys Ala Pro Arg Ile Glu Ser 
65                  70                  75                  80  

Gln Ala Ser Asn Gln Glu Lys Pro Leu Lys Glu Asp Ala Lys Ala Val 
                85                  90                  95      

Thr Asn Glu Glu Val Asn Gln Met Ile Glu Asp Arg Lys Val Asp Phe 
            100                 105                 110         

Asn Gln Asn Trp Tyr Phe Lys Leu Asn Ala Asn Ser Lys Glu Ala Ile 
        115                 120                 125             

Lys Pro Asp Ala Asp Val Ser Thr Trp Lys Lys Leu Asp Leu Pro Tyr 
    130                 135                 140                 

Asp Trp Ser Ile Phe Asn Asp Phe Asp His Glu Ser Pro Ala Gln Asn 
145                 150                 155                 160 

Glu Gly Gly Gln Leu Asn Gly Gly Glu Ala Trp Tyr Arg Lys Thr Phe 
                165                 170                 175     

Lys Leu Asp Glu Lys Asp Leu Lys Lys Asn Val Arg Leu Thr Phe Asp 
            180                 185                 190         

Gly Val Tyr Met Asp Ser Gln Val Tyr Val Asn Gly Gln Leu Val Gly 
        195                 200                 205             

His Tyr Pro Asn Gly Tyr Asn Gln Phe Ser Tyr Asp Ile Thr Lys Tyr 
    210                 215                 220                 

Leu Gln Lys Asp Gly Arg Glu Asn Val Ile Ala Val His Ala Val Asn 
225                 230                 235                 240 

Lys Gln Pro Ser Ser Arg Trp Tyr Ser Gly Ser Gly Ile Tyr Arg Asp 
                245                 250                 255     

Val Thr Leu Gln Val Thr Asp Lys Val His Val Glu Lys Asn Gly Thr 
            260                 265                 270         

Thr Ile Leu Thr Pro Lys Leu Glu Glu Gln Gln His Gly Lys Val Glu 
        275                 280                 285             

Thr His Val Thr Ser Lys Ile Val Asn Thr Asp Asp Lys Asp His Glu 
    290                 295                 300                 

Leu Val Ala Glu Tyr Gln Ile Val Glu Arg Gly Gly His Ala Val Thr 
305                 310                 315                 320 

Gly Leu Val Arg Thr Ala Ser Arg Thr Leu Lys Ala His Glu Ser Thr 
                325                 330                 335     

Ser Leu Asp Ala Ile Leu Glu Val Glu Arg Pro Lys Leu Trp Thr Val 
            340                 345                 350         

Leu Asn Asp Lys Pro Ala Leu Tyr Glu Leu Ile Thr Arg Val Tyr Arg 
        355                 360                 365             

Asp Gly Gln Leu Val Asp Ala Lys Lys Asp Leu Phe Gly Tyr Arg Tyr 
    370                 375                 380                 

Tyr His Trp Thr Pro Asn Glu Gly Phe Ser Leu Asn Gly Glu Arg Ile 
385                 390                 395                 400 

Lys Phe His Gly Val Ser Leu His His Asp His Gly Ala Leu Gly Ala 
                405                 410                 415     

Glu Glu Asn Tyr Lys Ala Glu Tyr Arg Arg Leu Lys Gln Met Lys Glu 
            420                 425                 430         

Met Gly Val Asn Ser Ile Arg Thr Thr His Asn Pro Ala Ser Glu Gln 
        435                 440                 445             

Thr Leu Gln Ile Ala Ala Glu Leu Gly Leu Leu Val Gln Glu Glu Ala 
    450                 455                 460                 

Phe Asp Thr Trp Tyr Gly Gly Lys Lys Pro Tyr Asp Tyr Gly Arg Phe 
465                 470                 475                 480 

Phe Glu Lys Asp Ala Thr His Pro Glu Ala Arg Lys Gly Glu Lys Trp 
                485                 490                 495     

Ser Asp Phe Asp Leu Arg Thr Met Val Glu Arg Gly Lys Asn Asn Pro 
            500                 505                 510         

Ala Ile Phe Met Trp Ser Ile Gly Asn Glu Ile Gly Glu Ala Asn Gly 
        515                 520                 525             

Asp Ala His Ser Leu Ala Thr Val Lys Arg Leu Val Lys Val Ile Lys 
    530                 535                 540                 

Asp Val Asp Lys Thr Arg Tyr Val Thr Met Gly Ala Asp Lys Phe Arg 
545                 550                 555                 560 

Phe Gly Asn Gly Ser Gly Gly His Glu Lys Ile Ala Asp Glu Leu Asp 
                565                 570                 575     

Ala Val Gly Phe Asn Tyr Ser Glu Asp Asn Tyr Lys Ala Leu Arg Ala 
            580                 585                 590         

Lys His Pro Lys Trp Leu Ile Tyr Gly Ser Glu Thr Ser Ser Ala Thr 
        595                 600                 605             

Arg Thr Arg Gly Ser Tyr Tyr Arg Pro Glu Arg Glu Leu Lys His Ser 
    610                 615                 620                 

Asn Gly Pro Glu Arg Asn Tyr Glu Gln Ser Asp Tyr Gly Asn Asp Arg 
625                 630                 635                 640 

Val Gly Trp Gly Lys Thr Ala Thr Ala Ser Trp Thr Phe Asp Arg Asp 
                645                 650                 655     

Asn Ala Gly Tyr Ala Gly Gln Phe Ile Trp Thr Gly Thr Asp Tyr Ile 
            660                 665                 670         

Gly Glu Pro Thr Pro Trp His Asn Gln Asn Gln Thr Pro Val Lys Ser 
        675                 680                 685             

Ser Tyr Phe Gly Ile Val Asp Thr Ala Gly Ile Pro Lys His Asp Phe 
    690                 695                 700                 

Tyr Leu Tyr Gln Ser Gln Trp Val Ser Val Lys Lys Lys Pro Met Val 
705                 710                 715                 720 

His Leu Leu Pro His Trp Asn Trp Glu Asn Lys Glu Leu Ala Ser Lys 
                725                 730                 735     

Val Ala Asp Ser Glu Gly Lys Ile Pro Val Arg Ala Tyr Ser Asn Ala 
            740                 745                 750         

Ser Ser Val Glu Leu Phe Leu Asn Gly Lys Ser Leu Gly Leu Lys Thr 
        755                 760                 765             

Phe Asn Lys Lys Gln Thr Ser Asp Gly Arg Thr Tyr Gln Glu Gly Ala 
    770                 775                 780                 

Asn Ala Asn Glu Leu Tyr Leu Glu Trp Lys Val Ala Tyr Gln Pro Gly 
785                 790                 795                 800 

Thr Leu Glu Ala Ile Ala Arg Asp Glu Ser Gly Lys Glu Ile Ala Arg 
                805                 810                 815     

Asp Lys Ile Thr Thr Ala Gly Lys Pro Ala Ala Val Arg Leu Ile Lys 
            820                 825                 830         

Glu Asp His Ala Ile Ala Ala Asp Gly Lys Asp Leu Thr Tyr Ile Tyr 
        835                 840                 845             

Tyr Glu Ile Val Asp Ser Gln Gly Asn Val Val Pro Thr Ala Asn Asn 
    850                 855                 860                 

Leu Val Arg Phe Gln Leu His Gly Gln Gly Gln Leu Val Gly Val Asp 
865                 870                 875                 880 

Asn Gly Glu Gln Ala Ser Arg Glu Arg Tyr Lys Ala Gln Ala Asp Gly 
                885                 890                 895     

Ser Trp Ile Arg Lys Ala Phe Asn Gly Lys Gly Val Ala Ile Val Lys 
            900                 905                 910         

Ser Thr Glu Gln Ala Gly Lys Phe Thr Leu Thr Ala His Ser Asp Leu 
        915                 920                 925             

Leu Lys Ser Asn Gln Val Thr Val Phe Thr Gly Lys Lys Glu Gly Gln 
    930                 935                 940                 

Glu Lys Thr Val Leu Gly Thr Glu Val Pro Lys Val Gln Thr Ile Ile 
945                 950                 955                 960 

Gly Glu Ala Pro Glu Met Pro Thr Thr Val Pro Phe Val Tyr Ser Asp 
                965                 970                 975     

Gly Ser Arg Ala Glu Arg Pro Val Thr Trp Ser Ser Val Asp Val Ser 
            980                 985                 990         

Lys Pro Gly Ile Val Thr Val Lys Gly Met Ala Asp Gly Arg Glu Val 
        995                 1000                1005            

Glu Ala Arg Val Glu Val Ile Ala Leu Lys Ser Glu Leu Pro Val Val 
    1010                1015                1020                

Lys Arg Ile Ala Pro Asn Thr Asp Leu Asn Ser Val Asp Lys Ser Val 
1025                1030                1035                1040

Ser Tyr Val Leu Ile Asp Gly Ser Val Glu Glu Tyr Glu Val Asp Lys 
                1045                1050                1055    

Trp Glu Ile Ala Glu Glu Asp Lys Ala Lys Gly Ser Gly Ser Gly Gly 
            1060                1065                1070        

Gly Gly Glu Thr Pro Glu Thr Ser Pro Ala Ile Gly Lys Val Val Ile 
        1075                1080                1085            

Lys Glu Thr Gly Glu Gly Gly Ala Leu Leu Gly Asp Ala Val Phe Glu 
    1090                1095                1100                

Leu Lys Asn Asn Thr Asp Gly Thr Thr Val Ser Gln Arg Thr Glu Ala 
1105                1110                1115                1120

Gln Thr Gly Glu Ala Ile Phe Ser Asn Ile Lys Pro Gly Thr Tyr Thr 
                1125                1130                1135    

Leu Thr Glu Ala Gln Pro Pro Val Gly Tyr Lys Pro Ser Thr Lys Gln 
            1140                1145                1150        

Trp Thr Val Glu Val Glu Lys Asn Gly Arg Thr Thr Val Gln Gly Glu 
        1155                1160                1165            

Gln Val Glu Asn Arg Glu Glu Ala Leu Ser Asp Gln Tyr Pro Gln Thr 
    1170                1175                1180                

Gly Thr Tyr Pro Asp Val Gln Thr Pro Tyr Gln Ile Ile Lys Val Asp 
1185                1190                1195                1200

Gly Ser Glu Lys Asn Gly Gln His Lys Ala Leu Asn Pro Asn Pro Tyr 
                1205                1210                1215    

Glu Arg Val Ile Pro Glu Gly Thr Leu Ser Lys Arg Ile Tyr Gln Val 
            1220                1225                1230        

Asn Asn Leu Asp Asp Asn Gln Tyr Gly Ile Glu Leu Thr Val Ser Gly 
        1235                1240                1245            

Lys Thr Val Tyr Glu Gln Lys Asp Lys Ser Val Pro Leu Asp Val Val 
    1250                1255                1260                

Ile Leu Leu Asp Asn Ser Asn Ser Met Ser Asn Ile Arg Asn Lys Asn 
1265                1270                1275                1280

Ala Arg Arg Ala Glu Arg Ala Gly Glu Ala Thr Arg Ser Leu Ile Asp 
                1285                1290                1295    

Lys Ile Thr Ser Asp Ser Glu Asn Arg Val Ala Leu Val Thr Tyr Ala 
            1300                1305                1310        

Ser Thr Ile Phe Asp Gly Thr Glu Phe Thr Val Glu Lys Gly Val Ala 
        1315                1320                1325            

Asp Lys Asn Gly Lys Arg Leu Asn Asp Ser Leu Phe Trp Asn Tyr Asp 
    1330                1335                1340                

Gln Thr Ser Phe Thr Thr Asn Thr Lys Asp Tyr Ser Tyr Leu Lys Leu 
1345                1350                1355                1360

Thr Asn Asp Lys Asn Asp Ile Val Glu Leu Lys Asn Lys Val Pro Thr 
                1365                1370                1375    

Glu Ala Glu Asp His Asp Gly Asn Arg Leu Met Tyr Gln Phe Gly Ala 
            1380                1385                1390        

Thr Phe Thr Gln Lys Ala Leu Met Lys Ala Asp Glu Ile Leu Thr Gln 
        1395                1400                1405            

Gln Ala Arg Gln Asn Ser Gln Lys Val Ile Phe His Ile Thr Asp Gly 
    1410                1415                1420                

Val Pro Thr Met Ser Tyr Pro Ile Asn Phe Asn His Ala Thr Phe Ala 
1425                1430                1435                1440

Pro Ser Tyr Gln Asn Gln Leu Asn Ala Phe Phe Ser Lys Ser Pro Asn 
                1445                1450                1455    

Lys Asp Gly Ile Leu Leu Ser Asp Phe Ile Thr Gln Ala Thr Ser Gly 
            1460                1465                1470        

Glu His Thr Ile Val Arg Gly Asp Gly Gln Ser Tyr Gln Met Phe Thr 
        1475                1480                1485            

Asp Lys Thr Val Tyr Glu Lys Gly Ala Pro Ala Ala Phe Pro Val Lys 
    1490                1495                1500                

Pro Glu Lys Tyr Ser Glu Met Lys Ala Ala Gly Tyr Ala Val Ile Gly 
1505                1510                1515                1520

Asp Pro Ile Asn Gly Gly Tyr Ile Trp Leu Asn Trp Arg Glu Ser Ile 
                1525                1530                1535    

Leu Ala Tyr Pro Phe Asn Ser Asn Thr Ala Lys Ile Thr Asn His Gly 
            1540                1545                1550        

Asp Pro Thr Arg Trp Tyr Tyr Asn Gly Asn Ile Ala Pro Asp Gly Tyr 
        1555                1560                1565            

Asp Val Phe Thr Val Gly Ile Gly Ile Asn Gly Asp Pro Gly Thr Asp 
    1570                1575                1580                

Glu Ala Thr Ala Thr Ser Phe Met Gln Ser Ile Ser Ser Lys Pro Glu 
1585                1590                1595                1600

Asn Tyr Thr Asn Val Thr Asp Thr Thr Lys Ile Leu Glu Gln Leu Asn 
                1605                1610                1615    

Arg Tyr Phe His Thr Ile Val Thr Glu Lys Lys Ser Ile Glu Asn Gly 
            1620                1625                1630        

Thr Ile Thr Asp Pro Met Gly Glu Leu Ile Asp Leu Gln Leu Gly Thr 
        1635                1640                1645            

Asp Gly Arg Phe Asp Pro Ala Asp Tyr Thr Leu Thr Ala Asn Asp Gly 
    1650                1655                1660                

Ser Arg Leu Glu Asn Gly Gln Ala Val Gly Gly Pro Gln Asn Asp Gly 
1665                1670                1675                1680

Gly Leu Leu Lys Asn Ala Lys Val Leu Tyr Asp Thr Thr Glu Lys Arg 
                1685                1690                1695    

Ile Arg Val Thr Gly Leu Tyr Leu Gly Thr Asp Glu Lys Val Thr Leu 
            1700                1705                1710        

Thr Tyr Asn Val Arg Leu Asn Asp Glu Phe Val Ser Asn Lys Phe Tyr 
        1715                1720                1725            

Asp Thr Asn Gly Arg Thr Thr Leu His Pro Lys Glu Val Glu Gln Asn 
    1730                1735                1740                

Thr Val Arg Asp Phe Pro Ile Pro Lys Ile Arg Asp Val Arg Lys Tyr 
1745                1750                1755                1760

Pro Glu Ile Thr Ile Ser Lys Glu Lys Lys Leu Gly Asp Ile Glu Phe 
                1765                1770                1775    

Ile Lys Val Asn Lys Asn Asp Lys Lys Pro Leu Arg Gly Ala Val Phe 
            1780                1785                1790        

Ser Leu Gln Lys Gln His Pro Asp Tyr Pro Asp Ile Tyr Gly Ala Ile 
        1795                1800                1805            

Asp Gln Asn Gly Thr Tyr Gln Asn Val Arg Thr Gly Glu Asp Gly Lys 
    1810                1815                1820                

Leu Thr Phe Lys Asn Leu Ser Asp Gly Lys Tyr Arg Leu Phe Glu Asn 
1825                1830                1835                1840

Ser Glu Pro Ala Gly Tyr Lys Pro Val Gln Asn Lys Pro Ile Val Ala 
                1845                1850                1855    

Phe Gln Ile Val Asn Gly Glu Val Arg Asp Val Thr Ser Ile Val Pro 
            1860                1865                1870        

Gln Asp Ile Pro Ala Gly Tyr Glu Phe Thr Asn Asp Lys His Tyr Ile 
        1875                1880                1885            

Thr Asn Glu Pro Ile Pro Pro Lys Arg Glu Leu Glu His His His His 
    1890                1895                1900                

His His 
1905    

<210>   228
<211>   1941
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Hybrid polypeptide

<400>   228
Met Ala Ser Ile Ala Glu Glu Asp Lys Ala Lys Leu Ala Ile Pro Gly 
1               5                   10                  15      

Ser Arg Ile Gln Ala Thr Gly Tyr Leu Glu Gly Gln Pro Ile His Ala 
            20                  25                  30          

Thr Leu Val Val Glu Glu Gly Asn Pro Ala Ala Pro Ala Val Pro Thr 
        35                  40                  45              

Val Thr Val Gly Gly Glu Ala Val Thr Gly Leu Thr Ser Gln Lys Pro 
    50                  55                  60                  

Met Gln Tyr Arg Thr Leu Ala Tyr Gly Ala Lys Leu Pro Glu Val Thr 
65                  70                  75                  80  

Ala Ser Ala Lys Asn Ala Ala Val Thr Val Leu Gln Ala Ser Ala Ala 
                85                  90                  95      

Asn Gly Met Arg Ala Ser Ile Phe Ile Gln Pro Lys Asp Gly Gly Pro 
            100                 105                 110         

Leu Gln Thr Tyr Ala Ile Gln Phe Leu Glu Glu Ala Pro Lys Ile Ala 
        115                 120                 125             

His Leu Ser Leu Gln Val Glu Lys Ala Asp Ser Leu Lys Glu Asp Gln 
    130                 135                 140                 

Thr Val Lys Leu Ser Val Arg Ala His Tyr Gln Asp Gly Thr Gln Ala 
145                 150                 155                 160 

Val Leu Pro Ala Asp Lys Val Thr Phe Ser Thr Ser Gly Glu Gly Glu 
                165                 170                 175     

Val Ala Ile Arg Lys Gly Met Leu Glu Leu His Lys Pro Gly Ala Val 
            180                 185                 190         

Thr Leu Asn Ala Glu Tyr Glu Gly Ala Lys Asp Gln Val Glu Leu Thr 
        195                 200                 205             

Ile Gln Ala Asn Thr Glu Lys Lys Ile Ala Gln Ser Ile Arg Pro Val 
    210                 215                 220                 

Asn Val Val Thr Asp Leu His Gln Glu Pro Ser Leu Pro Ala Thr Val 
225                 230                 235                 240 

Thr Val Glu Tyr Asp Lys Gly Phe Pro Lys Thr His Lys Val Thr Trp 
                245                 250                 255     

Gln Ala Ile Pro Lys Glu Lys Leu Asp Ser Tyr Gln Thr Phe Glu Val 
            260                 265                 270         

Leu Gly Lys Val Glu Gly Ile Asp Leu Glu Ala Arg Ala Lys Val Ser 
        275                 280                 285             

Val Glu Gly Ile Val Ser Val Glu Glu Val Ser Val Thr Thr Pro Ile 
    290                 295                 300                 

Ala Glu Ala Pro Gln Leu Pro Glu Ser Val Arg Thr Tyr Asp Ser Asn 
305                 310                 315                 320 

Gly His Val Ser Ser Ala Lys Val Ala Trp Asp Ala Ile Arg Pro Glu 
                325                 330                 335     

Gln Tyr Ala Lys Glu Gly Val Phe Thr Val Asn Gly Arg Leu Glu Gly 
            340                 345                 350         

Thr Gln Leu Thr Thr Lys Leu His Val Arg Val Ser Ala Gln Thr Glu 
        355                 360                 365             

Gln Gly Ala Asn Ile Ser Asp Gln Trp Thr Gly Ser Glu Leu Pro Leu 
    370                 375                 380                 

Ala Phe Ala Ser Asp Ser Asn Pro Ser Asp Pro Val Ser Asn Val Asn 
385                 390                 395                 400 

Asp Lys Leu Ile Ser Tyr Asn Asn Gln Pro Ala Asn Arg Trp Thr Asn 
                405                 410                 415     

Trp Asn Arg Thr Asn Pro Glu Ala Ser Val Gly Val Leu Phe Gly Asp 
            420                 425                 430         

Ser Gly Ile Leu Ser Lys Arg Ser Val Asp Asn Leu Ser Val Gly Phe 
        435                 440                 445             

His Glu Asp His Gly Val Gly Val Pro Lys Ser Tyr Val Ile Glu Tyr 
    450                 455                 460                 

Tyr Val Gly Lys Thr Val Pro Thr Ala Pro Lys Asn Pro Ser Phe Val 
465                 470                 475                 480 

Gly Asn Glu Asp His Val Phe Asn Asp Ser Ala Asn Trp Lys Pro Val 
                485                 490                 495     

Thr Asn Leu Lys Ala Pro Ala Gln Leu Lys Ala Gly Glu Met Asn His 
            500                 505                 510         

Phe Ser Phe Asp Lys Val Glu Thr Tyr Ala Val Arg Ile Arg Met Val 
        515                 520                 525             

Lys Ala Asp Asn Lys Arg Gly Thr Ser Ile Thr Glu Val Gln Ile Phe 
    530                 535                 540                 

Ala Lys Gln Val Ala Ala Ala Lys Gln Gly Gln Thr Arg Ile Gln Val 
545                 550                 555                 560 

Asp Gly Lys Asp Leu Ala Asn Phe Asn Pro Asp Leu Thr Asp Tyr Tyr 
                565                 570                 575     

Leu Glu Ser Val Asp Gly Lys Val Pro Ala Val Thr Ala Ser Val Ser 
            580                 585                 590         

Asn Asn Gly Leu Ala Thr Val Val Pro Ser Val Arg Glu Gly Glu Pro 
        595                 600                 605             

Val Arg Val Ile Ala Lys Ala Glu Asn Gly Asp Ile Leu Gly Glu Tyr 
    610                 615                 620                 

Arg Leu His Phe Thr Lys Asp Lys Ser Leu Leu Ser His Lys Pro Val 
625                 630                 635                 640 

Ala Ala Val Lys Gln Ala Arg Leu Leu Gln Val Gly Gln Ala Leu Glu 
                645                 650                 655     

Leu Pro Thr Lys Val Pro Val Tyr Phe Thr Gly Lys Asp Gly Tyr Glu 
            660                 665                 670         

Thr Lys Asp Leu Thr Val Glu Trp Glu Glu Val Pro Ala Glu Asn Leu 
        675                 680                 685             

Thr Lys Ala Gly Gln Phe Thr Val Arg Gly Arg Val Leu Gly Ser Asn 
    690                 695                 700                 

Leu Val Ala Glu Ile Thr Val Arg Val Thr Asp Lys Leu Gly Glu Thr 
705                 710                 715                 720 

Leu Ser Asp Asn Pro Asn Tyr Asp Glu Asn Ser Asn Gln Ala Phe Ala 
                725                 730                 735     

Ser Ala Thr Asn Asp Ile Asp Lys Asn Ser His Asp Arg Val Asp Tyr 
            740                 745                 750         

Leu Asn Asp Gly Asp His Ser Glu Asn Arg Arg Trp Thr Asn Trp Ser 
        755                 760                 765             

Pro Thr Pro Ser Ser Asn Pro Glu Val Ser Ala Gly Val Ile Phe Arg 
    770                 775                 780                 

Glu Asn Gly Lys Ile Val Glu Arg Thr Val Thr Gln Gly Lys Val Gln 
785                 790                 795                 800 

Phe Phe Ala Asp Ser Gly Thr Asp Ala Pro Ser Lys Leu Val Leu Glu 
                805                 810                 815     

Arg Tyr Val Gly Pro Glu Phe Glu Val Pro Thr Tyr Tyr Ser Asn Tyr 
            820                 825                 830         

Gln Ala Tyr Asp Ala Asp His Pro Phe Asn Asn Pro Glu Asn Trp Glu 
        835                 840                 845             

Ala Val Pro Tyr Arg Ala Asp Lys Asp Ile Ala Ala Gly Asp Glu Ile 
    850                 855                 860                 

Asn Val Thr Phe Lys Ala Ile Lys Ala Lys Ala Met Arg Trp Arg Met 
865                 870                 875                 880 

Glu Arg Lys Ala Asp Lys Ser Gly Val Ala Met Ile Glu Met Thr Phe 
                885                 890                 895     

Leu Ala Pro Ser Glu Leu Pro Gln Glu Ser Thr Gln Ser Lys Ile Leu 
            900                 905                 910         

Val Asp Gly Lys Glu Leu Ala Asp Phe Ala Glu Asn Arg Gln Asp Tyr 
        915                 920                 925             

Gln Ile Thr Tyr Lys Gly Gln Arg Pro Lys Val Ser Val Glu Glu Asn 
    930                 935                 940                 

Asn Gln Val Ala Ser Thr Val Val Asp Ser Gly Glu Asp Ser Phe Pro 
945                 950                 955                 960 

Val Leu Val Arg Leu Val Ser Glu Ser Gly Lys Gln Val Lys Glu Tyr 
                965                 970                 975     

Arg Ile His Leu Thr Lys Glu Lys Pro Val Ser Glu Lys Thr Val Ala 
            980                 985                 990         

Ala Val Gln Glu Asp Leu Pro Lys Ile Glu Phe Val Glu Lys Asp Leu 
        995                 1000                1005            

Ala Tyr Lys Thr Val Glu Lys Lys Asp Ser Thr Leu Tyr Leu Gly Glu 
    1010                1015                1020                

Thr Arg Val Glu Gln Glu Gly Lys Val Gly Lys Glu Arg Ile Phe Thr 
1025                1030                1035                1040

Ala Ile Asn Pro Asp Gly Ser Lys Glu Glu Lys Leu Arg Glu Val Val 
                1045                1050                1055    

Glu Val Pro Thr Asp Arg Ile Val Leu Val Gly Thr Lys Pro Val Ala 
            1060                1065                1070        

Gln Glu Ala Lys Lys Pro Gln Val Ser Glu Lys Ala Asp Thr Lys Pro 
        1075                1080                1085            

Ile Asp Ser Ser Glu Ala Ser Gln Thr Asn Lys Ala Gln Gly Ser Gly 
    1090                1095                1100                

Ser Gly Gly Gly Gly Glu Thr Pro Glu Thr Ser Pro Ala Ile Gly Lys 
1105                1110                1115                1120

Val Val Ile Lys Glu Thr Gly Glu Gly Gly Ala Leu Leu Gly Asp Ala 
                1125                1130                1135    

Val Phe Glu Leu Lys Asn Asn Thr Asp Gly Thr Thr Val Ser Gln Arg 
            1140                1145                1150        

Thr Glu Ala Gln Thr Gly Glu Ala Ile Phe Ser Asn Ile Lys Pro Gly 
        1155                1160                1165            

Thr Tyr Thr Leu Thr Glu Ala Gln Pro Pro Val Gly Tyr Lys Pro Ser 
    1170                1175                1180                

Thr Lys Gln Trp Thr Val Glu Val Glu Lys Asn Gly Arg Thr Thr Val 
1185                1190                1195                1200

Gln Gly Glu Gln Val Glu Asn Arg Glu Glu Ala Leu Ser Asp Gln Tyr 
                1205                1210                1215    

Pro Gln Thr Gly Thr Tyr Pro Asp Val Gln Thr Pro Tyr Gln Ile Ile 
            1220                1225                1230        

Lys Val Asp Gly Ser Glu Lys Asn Gly Gln His Lys Ala Leu Asn Pro 
        1235                1240                1245            

Asn Pro Tyr Glu Arg Val Ile Pro Glu Gly Thr Leu Ser Lys Arg Ile 
    1250                1255                1260                

Tyr Gln Val Asn Asn Leu Asp Asp Asn Gln Tyr Gly Ile Glu Leu Thr 
1265                1270                1275                1280

Val Ser Gly Lys Thr Val Tyr Glu Gln Lys Asp Lys Ser Val Pro Leu 
                1285                1290                1295    

Asp Val Val Ile Leu Leu Asp Asn Ser Asn Ser Met Ser Asn Ile Arg 
            1300                1305                1310        

Asn Lys Asn Ala Arg Arg Ala Glu Arg Ala Gly Glu Ala Thr Arg Ser 
        1315                1320                1325            

Leu Ile Asp Lys Ile Thr Ser Asp Ser Glu Asn Arg Val Ala Leu Val 
    1330                1335                1340                

Thr Tyr Ala Ser Thr Ile Phe Asp Gly Thr Glu Phe Thr Val Glu Lys 
1345                1350                1355                1360

Gly Val Ala Asp Lys Asn Gly Lys Arg Leu Asn Asp Ser Leu Phe Trp 
                1365                1370                1375    

Asn Tyr Asp Gln Thr Ser Phe Thr Thr Asn Thr Lys Asp Tyr Ser Tyr 
            1380                1385                1390        

Leu Lys Leu Thr Asn Asp Lys Asn Asp Ile Val Glu Leu Lys Asn Lys 
        1395                1400                1405            

Val Pro Thr Glu Ala Glu Asp His Asp Gly Asn Arg Leu Met Tyr Gln 
    1410                1415                1420                

Phe Gly Ala Thr Phe Thr Gln Lys Ala Leu Met Lys Ala Asp Glu Ile 
1425                1430                1435                1440

Leu Thr Gln Gln Ala Arg Gln Asn Ser Gln Lys Val Ile Phe His Ile 
                1445                1450                1455    

Thr Asp Gly Val Pro Thr Met Ser Tyr Pro Ile Asn Phe Asn His Ala 
            1460                1465                1470        

Thr Phe Ala Pro Ser Tyr Gln Asn Gln Leu Asn Ala Phe Phe Ser Lys 
        1475                1480                1485            

Ser Pro Asn Lys Asp Gly Ile Leu Leu Ser Asp Phe Ile Thr Gln Ala 
    1490                1495                1500                

Thr Ser Gly Glu His Thr Ile Val Arg Gly Asp Gly Gln Ser Tyr Gln 
1505                1510                1515                1520

Met Phe Thr Asp Lys Thr Val Tyr Glu Lys Gly Ala Pro Ala Ala Phe 
                1525                1530                1535    

Pro Val Lys Pro Glu Lys Tyr Ser Glu Met Lys Ala Ala Gly Tyr Ala 
            1540                1545                1550        

Val Ile Gly Asp Pro Ile Asn Gly Gly Tyr Ile Trp Leu Asn Trp Arg 
        1555                1560                1565            

Glu Ser Ile Leu Ala Tyr Pro Phe Asn Ser Asn Thr Ala Lys Ile Thr 
    1570                1575                1580                

Asn His Gly Asp Pro Thr Arg Trp Tyr Tyr Asn Gly Asn Ile Ala Pro 
1585                1590                1595                1600

Asp Gly Tyr Asp Val Phe Thr Val Gly Ile Gly Ile Asn Gly Asp Pro 
                1605                1610                1615    

Gly Thr Asp Glu Ala Thr Ala Thr Ser Phe Met Gln Ser Ile Ser Ser 
            1620                1625                1630        

Lys Pro Glu Asn Tyr Thr Asn Val Thr Asp Thr Thr Lys Ile Leu Glu 
        1635                1640                1645            

Gln Leu Asn Arg Tyr Phe His Thr Ile Val Thr Glu Lys Lys Ser Ile 
    1650                1655                1660                

Glu Asn Gly Thr Ile Thr Asp Pro Met Gly Glu Leu Ile Asp Leu Gln 
1665                1670                1675                1680

Leu Gly Thr Asp Gly Arg Phe Asp Pro Ala Asp Tyr Thr Leu Thr Ala 
                1685                1690                1695    

Asn Asp Gly Ser Arg Leu Glu Asn Gly Gln Ala Val Gly Gly Pro Gln 
            1700                1705                1710        

Asn Asp Gly Gly Leu Leu Lys Asn Ala Lys Val Leu Tyr Asp Thr Thr 
        1715                1720                1725            

Glu Lys Arg Ile Arg Val Thr Gly Leu Tyr Leu Gly Thr Asp Glu Lys 
    1730                1735                1740                

Val Thr Leu Thr Tyr Asn Val Arg Leu Asn Asp Glu Phe Val Ser Asn 
1745                1750                1755                1760

Lys Phe Tyr Asp Thr Asn Gly Arg Thr Thr Leu His Pro Lys Glu Val 
                1765                1770                1775    

Glu Gln Asn Thr Val Arg Asp Phe Pro Ile Pro Lys Ile Arg Asp Val 
            1780                1785                1790        

Arg Lys Tyr Pro Glu Ile Thr Ile Ser Lys Glu Lys Lys Leu Gly Asp 
        1795                1800                1805            

Ile Glu Phe Ile Lys Val Asn Lys Asn Asp Lys Lys Pro Leu Arg Gly 
    1810                1815                1820                

Ala Val Phe Ser Leu Gln Lys Gln His Pro Asp Tyr Pro Asp Ile Tyr 
1825                1830                1835                1840

Gly Ala Ile Asp Gln Asn Gly Thr Tyr Gln Asn Val Arg Thr Gly Glu 
                1845                1850                1855    

Asp Gly Lys Leu Thr Phe Lys Asn Leu Ser Asp Gly Lys Tyr Arg Leu 
            1860                1865                1870        

Phe Glu Asn Ser Glu Pro Ala Gly Tyr Lys Pro Val Gln Asn Lys Pro 
        1875                1880                1885            

Ile Val Ala Phe Gln Ile Val Asn Gly Glu Val Arg Asp Val Thr Ser 
    1890                1895                1900                

Ile Val Pro Gln Asp Ile Pro Ala Gly Tyr Glu Phe Thr Asn Asp Lys 
1905                1910                1915                1920

His Tyr Ile Thr Asn Glu Pro Ile Pro Pro Lys Arg Glu Leu Glu His 
                1925                1930                1935    

His His His His His 
            1940    

<210>   229
<211>   141
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   229
Val Ser Ala Gln Glu Ser Ser Thr Tyr Thr Val Lys Glu Gly Asp Thr 
1               5                   10                  15      

Leu Ser Glu Ile Ala Glu Thr His Asn Thr Thr Val Glu Lys Leu Ala 
            20                  25                  30          

Glu Asn Asn His Ile Asp Asn Ile His Leu Ile Tyr Val Asp Gln Glu 
        35                  40                  45              

Leu Val Ile Asp Gly Pro Val Ala Pro Val Ala Thr Pro Ala Pro Ala 
    50                  55                  60                  

Thr Tyr Ala Ala Pro Ala Ala Gln Asp Glu Thr Val Ser Ala Pro Val 
65                  70                  75                  80  

Ala Glu Thr Pro Val Val Ser Glu Thr Val Val Ser Thr Val Ser Gly 
                85                  90                  95      

Ser Glu Ala Glu Ala Lys Glu Trp Ile Ala Gln Lys Glu Ser Gly Gly 
            100                 105                 110         

Ser Tyr Thr Ala Thr Asn Gly Arg Tyr Ile Gly Arg Tyr Gly Ser Trp 
        115                 120                 125             

Thr Ala Ala Lys Asn Phe Trp Leu Asn Asn Gly Trp Tyr 
    130                 135                 140     

<210>   230
<211>   26
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Poly(dIdC) oligonucleotide for IC-31

<220>
<221>   N
<222>   1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25
<223>   N is Inosine

<400>   230
ncncncncnc ncncncncnc ncncnc                                        26

<210>   231
<211>   11
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Polycationic polymer for IC-31

<400>   231
Lys Leu Lys Leu Leu Leu Leu Leu Lys Leu Lys 
1               5                   10      

<210>   232
<211>   6
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Glycine-rich linker

<400>   232
Gly Ser Gly Gly Gly Gly 
1               5       

<210>   233
<211>   8
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Glycine-rich linker

<400>   233
Gly Ser Gly Ser Gly Gly Gly Gly 
1               5               

<210>   234
<211>   6
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Hexa-histidine tag

<400>   234
His His His His His His 
1               5       

<210>   235
<211>   5
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Linker peptide

<400>   235
Ala Ala Ala Leu Glu 
1               5   

<210>   236
<211>   665
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   236
Met Lys Ser Ile Asn Lys Phe Leu Thr Met Leu Ala Ala Leu Leu Leu 
1               5                   10                  15      

Thr Ala Ser Ser Leu Phe Ser Ala Ala Thr Val Phe Ala Ala Gly Thr 
            20                  25                  30          

Thr Thr Thr Ser Val Thr Val His Lys Leu Leu Ala Thr Asp Gly Asp 
        35                  40                  45              

Met Asp Lys Ile Ala Asn Glu Leu Glu Thr Gly Asn Tyr Ala Gly Asn 
    50                  55                  60                  

Lys Val Gly Val Leu Pro Ala Asn Ala Lys Glu Ile Ala Gly Val Met 
65                  70                  75                  80  

Phe Val Trp Thr Asn Thr Asn Asn Glu Ile Ile Asp Glu Asn Gly Gln 
                85                  90                  95      

Thr Leu Gly Val Asn Ile Asp Pro Gln Thr Phe Lys Leu Ser Gly Ala 
            100                 105                 110         

Met Pro Ala Thr Ala Met Lys Lys Leu Thr Glu Ala Glu Gly Ala Lys 
        115                 120                 125             

Phe Asn Thr Ala Asn Leu Pro Ala Ala Lys Tyr Lys Ile Tyr Glu Ile 
    130                 135                 140                 

His Ser Leu Ser Thr Tyr Val Gly Glu Asp Gly Ala Thr Leu Thr Gly 
145                 150                 155                 160 

Ser Lys Ala Val Pro Ile Glu Ile Glu Leu Pro Leu Asn Asp Val Val 
                165                 170                 175     

Asp Ala His Val Tyr Pro Lys Asn Thr Glu Ala Lys Pro Lys Ile Asp 
            180                 185                 190         

Lys Asp Phe Lys Gly Lys Ala Asn Pro Asp Thr Pro Arg Val Asp Lys 
        195                 200                 205             

Asp Thr Pro Val Asn His Gln Val Gly Asp Val Val Glu Tyr Glu Ile 
    210                 215                 220                 

Val Thr Lys Ile Pro Ala Leu Ala Asn Tyr Ala Thr Ala Asn Trp Ser 
225                 230                 235                 240 

Asp Arg Met Thr Glu Gly Leu Ala Phe Asn Lys Gly Thr Val Lys Val 
                245                 250                 255     

Thr Val Asp Asp Val Ala Leu Glu Ala Gly Asp Tyr Ala Leu Thr Glu 
            260                 265                 270         

Val Ala Thr Gly Phe Asp Leu Lys Leu Thr Asp Ala Gly Leu Ala Lys 
        275                 280                 285             

Val Asn Asp Gln Asn Ala Glu Lys Thr Val Lys Ile Thr Tyr Ser Ala 
    290                 295                 300                 

Thr Leu Asn Asp Lys Ala Ile Val Glu Val Pro Glu Ser Asn Asp Val 
305                 310                 315                 320 

Thr Phe Asn Tyr Gly Asn Asn Pro Asp His Gly Asn Thr Pro Lys Pro 
                325                 330                 335     

Asn Lys Pro Asn Glu Asn Gly Asp Leu Thr Leu Thr Lys Thr Trp Val 
            340                 345                 350         

Asp Ala Thr Gly Ala Pro Ile Pro Ala Gly Ala Glu Ala Thr Phe Asp 
        355                 360                 365             

Leu Val Asn Ala Gln Thr Gly Lys Val Val Gln Thr Val Thr Leu Thr 
    370                 375                 380                 

Thr Asp Lys Asn Thr Val Thr Val Asn Gly Leu Asp Lys Asn Thr Glu 
385                 390                 395                 400 

Tyr Lys Phe Val Glu Arg Ser Ile Lys Gly Tyr Ser Ala Asp Tyr Gln 
                405                 410                 415     

Glu Ile Thr Thr Ala Gly Glu Ile Ala Val Lys Asn Trp Lys Asp Glu 
            420                 425                 430         

Asn Pro Lys Pro Leu Asp Pro Thr Glu Pro Lys Val Val Thr Tyr Gly 
        435                 440                 445             

Lys Lys Phe Val Lys Val Asn Asp Lys Asp Asn Arg Leu Ala Gly Ala 
    450                 455                 460                 

Glu Phe Val Ile Ala Asn Ala Asp Asn Ala Gly Gln Tyr Leu Ala Arg 
465                 470                 475                 480 

Lys Ala Asp Lys Val Ser Gln Glu Glu Lys Gln Leu Val Val Thr Thr 
                485                 490                 495     

Lys Asp Ala Leu Asp Arg Ala Val Ala Ala Tyr Asn Ala Leu Thr Ala 
            500                 505                 510         

Gln Gln Gln Thr Gln Gln Glu Lys Glu Lys Val Asp Lys Ala Gln Ala 
        515                 520                 525             

Ala Tyr Asn Ala Ala Val Ile Ala Ala Asn Asn Ala Phe Glu Trp Val 
    530                 535                 540                 

Ala Asp Lys Asp Asn Glu Asn Val Val Lys Leu Val Ser Asp Ala Gln 
545                 550                 555                 560 

Gly Arg Phe Glu Ile Thr Gly Leu Leu Ala Gly Thr Tyr Tyr Leu Glu 
                565                 570                 575     

Glu Thr Lys Gln Pro Ala Gly Tyr Ala Leu Leu Thr Ser Arg Gln Lys 
            580                 585                 590         

Phe Glu Val Thr Ala Thr Ser Tyr Ser Ala Thr Gly Gln Gly Ile Glu 
        595                 600                 605             

Tyr Thr Ala Gly Ser Gly Lys Asp Asp Ala Thr Lys Val Val Asn Lys 
    610                 615                 620                 

Lys Ile Thr Ile Pro Gln Thr Gly Gly Ile Gly Thr Ile Ile Phe Ala 
625                 630                 635                 640 

Val Ala Gly Ala Ala Ile Met Gly Ile Ala Val Tyr Ala Tyr Val Lys 
                645                 650                 655     

Asn Asn Lys Asp Glu Asp Gln Leu Ala 
            660                 665 

<210>   237
<211>   644
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   237
Met Lys Ser Ile Asn Lys Phe Leu Thr Met Leu Ala Ala Leu Leu Leu 
1               5                   10                  15      

Thr Ala Ser Ser Leu Phe Ser Ala Ala Thr Val Phe Ala Ala Asp Asn 
            20                  25                  30          

Val Ser Thr Ala Pro Asp Ala Val Thr Lys Thr Leu Thr Ile His Lys 
        35                  40                  45              

Leu Leu Leu Ser Glu Asp Asp Leu Lys Thr Trp Asp Thr Asn Gly Pro 
    50                  55                  60                  

Lys Gly Tyr Asp Gly Thr Gln Ser Ser Leu Lys Asp Leu Thr Gly Val 
65                  70                  75                  80  

Val Ala Glu Glu Ile Pro Asn Val Tyr Phe Glu Leu Gln Lys Tyr Asn 
                85                  90                  95      

Leu Thr Asp Gly Lys Glu Lys Glu Asn Leu Lys Asp Asp Ser Lys Trp 
            100                 105                 110         

Thr Thr Val His Gly Gly Leu Thr Thr Lys Asp Gly Leu Lys Ile Glu 
        115                 120                 125             

Thr Ser Thr Leu Lys Gly Val Tyr Arg Ile Arg Glu Asp Arg Thr Lys 
    130                 135                 140                 

Thr Thr Tyr Val Gly Pro Asn Gly Gln Val Leu Thr Gly Ser Lys Ala 
145                 150                 155                 160 

Val Pro Ala Leu Val Thr Leu Pro Leu Val Asn Asn Asn Gly Thr Val 
                165                 170                 175     

Ile Asp Ala His Val Phe Pro Lys Asn Ser Tyr Asn Lys Pro Val Val 
            180                 185                 190         

Asp Lys Arg Ile Ala Asp Thr Leu Asn Tyr Asn Asp Gln Asn Gly Leu 
        195                 200                 205             

Ser Ile Gly Thr Lys Ile Pro Tyr Val Val Asn Thr Thr Ile Pro Ser 
    210                 215                 220                 

Asn Ala Thr Phe Ala Thr Ser Phe Trp Ser Asp Glu Met Thr Glu Gly 
225                 230                 235                 240 

Leu Thr Tyr Asn Glu Asp Val Thr Ile Thr Leu Asn Asn Val Ala Met 
                245                 250                 255     

Asp Gln Ala Asp Tyr Glu Val Thr Lys Gly Asn Asn Gly Phe Asn Leu 
            260                 265                 270         

Lys Leu Thr Glu Ala Gly Leu Ala Lys Ile Asn Gly Lys Asp Ala Asp 
        275                 280                 285             

Gln Lys Ile Gln Ile Thr Tyr Ser Ala Thr Leu Asn Ser Leu Ala Val 
    290                 295                 300                 

Ala Asp Ile Pro Glu Ser Asn Asp Ile Thr Tyr His Tyr Gly Asn His 
305                 310                 315                 320 

Gln Asp His Gly Asn Thr Pro Lys Pro Thr Lys Pro Asn Asn Gly Gln 
                325                 330                 335     

Ile Thr Val Thr Lys Thr Trp Asp Ser Gln Pro Ala Pro Glu Gly Val 
            340                 345                 350         

Lys Ala Thr Val Gln Leu Val Asn Ala Lys Thr Gly Glu Lys Val Gly 
        355                 360                 365             

Ala Pro Val Glu Leu Ser Glu Asn Asn Trp Thr Tyr Thr Trp Ser Gly 
    370                 375                 380                 

Leu Asp Asn Ser Ile Glu Tyr Lys Val Glu Glu Glu Tyr Asn Gly Tyr 
385                 390                 395                 400 

Ser Ala Glu Tyr Thr Val Glu Ser Lys Gly Lys Leu Gly Val Lys Asn 
                405                 410                 415     

Trp Lys Asp Asn Asn Pro Ala Pro Ile Asn Pro Glu Glu Pro Arg Val 
            420                 425                 430         

Lys Thr Tyr Gly Lys Lys Phe Val Lys Val Asp Gln Lys Asp Thr Arg 
        435                 440                 445             

Leu Glu Asn Ala Gln Phe Val Val Lys Lys Ala Asp Ser Asn Lys Tyr 
    450                 455                 460                 

Ile Ala Phe Lys Ser Thr Ala Gln Gln Ala Ala Asp Glu Lys Ala Ala 
465                 470                 475                 480 

Ala Thr Ala Lys Gln Lys Leu Asp Ala Ala Val Ala Ala Tyr Thr Asn 
                485                 490                 495     

Ala Ala Asp Lys Gln Ala Ala Gln Ala Leu Val Asp Gln Ala Gln Gln 
            500                 505                 510         

Glu Tyr Asn Val Ala Tyr Lys Glu Ala Lys Phe Gly Tyr Val Glu Val 
        515                 520                 525             

Ala Gly Lys Asp Glu Ala Met Val Leu Thr Ser Asn Thr Asp Gly Gln 
    530                 535                 540                 

Phe Gln Ile Ser Gly Leu Ala Ala Gly Thr Tyr Lys Leu Glu Glu Ile 
545                 550                 555                 560 

Lys Ala Pro Glu Gly Phe Ala Lys Ile Asp Asp Val Glu Phe Val Val 
                565                 570                 575     

Gly Ala Gly Ser Trp Asn Gln Gly Glu Phe Asn Tyr Leu Lys Asp Val 
            580                 585                 590         

Gln Lys Asn Asp Ala Thr Lys Val Val Asn Lys Lys Ile Thr Ile Pro 
        595                 600                 605             

Gln Thr Gly Gly Ile Gly Thr Ile Ile Phe Ala Val Ala Gly Ala Ala 
    610                 615                 620                 

Ile Met Gly Ile Ala Val Tyr Ala Tyr Val Lys Asn Asn Lys Asp Glu 
625                 630                 635                 640 

Asp Gln Leu Ala 
                

<210>   238
<211>   654
<212>   PRT
<213>   Streptococcus pneumoniae

<400>   238
Met Lys Ser Ile Asn Lys Phe Leu Thr Ile Leu Ala Ala Leu Leu Leu 
1               5                   10                  15      

Thr Val Ser Ser Leu Phe Ser Ala Ala Thr Val Phe Ala Ala Glu Gln 
            20                  25                  30          

Lys Thr Lys Thr Leu Thr Val His Lys Leu Leu Met Thr Asp Gln Glu 
        35                  40                  45              

Leu Asp Ala Trp Asn Ser Asp Ala Ile Thr Thr Ala Gly Tyr Asp Gly 
    50                  55                  60                  

Ser Gln Asn Phe Glu Gln Phe Lys Gln Leu Gln Gly Val Pro Gln Gly 
65                  70                  75                  80  

Val Thr Glu Ile Ser Gly Val Ala Phe Glu Leu Gln Ser Tyr Thr Gly 
                85                  90                  95      

Pro Gln Gly Lys Glu Gln Glu Asn Leu Thr Asn Asp Ala Val Trp Thr 
            100                 105                 110         

Ala Val Asn Lys Gly Val Thr Thr Glu Thr Gly Val Lys Phe Asp Thr 
        115                 120                 125             

Glu Val Leu Gln Gly Thr Tyr Arg Leu Val Glu Val Arg Lys Glu Ser 
    130                 135                 140                 

Thr Tyr Val Gly Pro Asn Gly Lys Val Leu Thr Gly Met Lys Ala Val 
145                 150                 155                 160 

Pro Ala Leu Ile Thr Leu Pro Leu Val Asn Gln Asn Gly Val Val Glu 
                165                 170                 175     

Asn Ala His Val Tyr Pro Lys Asn Ser Glu Asp Lys Pro Thr Ala Thr 
            180                 185                 190         

Lys Thr Phe Asp Thr Ala Ala Gly Phe Val Asp Pro Gly Glu Lys Gly 
        195                 200                 205             

Leu Ala Ile Gly Thr Lys Val Pro Tyr Ile Val Thr Thr Thr Ile Pro 
    210                 215                 220                 

Lys Asn Ser Thr Leu Ala Thr Ala Phe Trp Ser Asp Glu Met Thr Glu 
225                 230                 235                 240 

Gly Leu Asp Tyr Asn Gly Asp Val Val Val Asn Tyr Asn Gly Gln Pro 
                245                 250                 255     

Leu Asp Asn Ser His Tyr Thr Leu Glu Ala Gly His Asn Gly Phe Ile 
            260                 265                 270         

Leu Lys Leu Asn Glu Lys Gly Leu Glu Ala Ile Asn Gly Lys Asp Ala 
        275                 280                 285             

Glu Ala Thr Ile Thr Leu Lys Tyr Thr Ala Thr Leu Asn Ala Leu Ala 
    290                 295                 300                 

Val Ala Asp Val Pro Glu Ala Asn Asp Val Thr Phe His Tyr Gly Asn 
305                 310                 315                 320 

Asn Pro Gly His Gly Asn Thr Pro Lys Pro Asn Lys Pro Lys Asn Gly 
                325                 330                 335     

Glu Leu Thr Ile Thr Lys Thr Trp Ala Asp Ala Lys Asp Ala Pro Ile 
            340                 345                 350         

Ala Gly Val Glu Val Thr Phe Asp Leu Val Asn Ala Gln Thr Gly Glu 
        355                 360                 365             

Val Val Lys Val Pro Gly His Glu Thr Gly Ile Val Leu Asn Gln Thr 
    370                 375                 380                 

Asn Asn Trp Thr Phe Thr Ala Thr Gly Leu Asp Asn Asn Thr Glu Tyr 
385                 390                 395                 400 

Lys Phe Val Glu Arg Thr Ile Lys Gly Tyr Ser Ala Asp Tyr Gln Thr 
                405                 410                 415     

Ile Thr Glu Thr Gly Lys Ile Ala Val Lys Asn Trp Lys Asp Glu Asn 
            420                 425                 430         

Pro Glu Pro Ile Asn Pro Glu Glu Pro Arg Val Lys Thr Tyr Gly Lys 
        435                 440                 445             

Lys Phe Val Lys Val Asp Gln Lys Asp Glu Arg Leu Lys Glu Ala Gln 
    450                 455                 460                 

Phe Val Val Lys Asn Glu Gln Gly Lys Tyr Leu Ala Leu Lys Ser Ala 
465                 470                 475                 480 

Ala Gln Gln Ala Val Asn Glu Lys Ala Ala Ala Glu Ala Lys Gln Ala 
                485                 490                 495     

Leu Asp Ala Ala Ile Ala Ala Tyr Thr Asn Ala Ala Asp Lys Asn Ala 
            500                 505                 510         

Ala Gln Ala Val Val Asp Ala Ala Gln Lys Thr Tyr Asn Asp Asn Tyr 
        515                 520                 525             

Arg Ala Ala Arg Phe Gly Tyr Val Glu Val Glu Arg Lys Glu Asp Ala 
    530                 535                 540                 

Leu Val Leu Thr Ser Asn Thr Asp Gly Gln Phe Gln Ile Ser Gly Leu 
545                 550                 555                 560 

Ala Ala Gly Ser Tyr Thr Leu Glu Glu Thr Lys Ala Pro Glu Gly Phe 
                565                 570                 575     

Ala Lys Leu Gly Asp Val Lys Phe Glu Val Gly Ala Gly Ser Trp Asn 
            580                 585                 590         

Gln Gly Asp Phe Asn Tyr Leu Lys Asp Val Gln Lys Asn Asp Ala Thr 
        595                 600                 605             

Lys Val Val Asn Lys Lys Ile Thr Ile Pro Gln Thr Gly Gly Ile Gly 
    610                 615                 620                 

Thr Ile Ile Phe Ala Val Ala Gly Ala Val Ile Met Gly Ile Ala Val 
625                 630                 635                 640 

Tyr Ala Tyr Val Lys Asn Asn Lys Asp Glu Asp Gln Leu Ala 
                645                 650                 

<210>   239
<211>   604
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   Fragment of SEQ ID NO: 236

<400>   239
Ala Ala Thr Val Phe Ala Ala Gly Thr Thr Thr Thr Ser Val Thr Val 
1               5                   10                  15      

His Lys Leu Leu Ala Thr Asp Gly Asp Met Asp Lys Ile Ala Asn Glu 
            20                  25                  30          

Leu Glu Thr Gly Asn Tyr Ala Gly Asn Lys Val Gly Val Leu Pro Ala 
        35                  40                  45              

Asn Ala Lys Glu Ile Ala Gly Val Met Phe Val Trp Thr Asn Thr Asn 
    50                  55                  60                  

Asn Glu Ile Ile Asp Glu Asn Gly Gln Thr Leu Gly Val Asn Ile Asp 
65                  70                  75                  80  

Pro Gln Thr Phe Lys Leu Ser Gly Ala Met Pro Ala Thr Ala Met Lys 
                85                  90                  95      

Lys Leu Thr Glu Ala Glu Gly Ala Lys Phe Asn Thr Ala Asn Leu Pro 
            100                 105                 110         

Ala Ala Lys Tyr Lys Ile Tyr Glu Ile His Ser Leu Ser Thr Tyr Val 
        115                 120                 125             

Gly Glu Asp Gly Ala Thr Leu Thr Gly Ser Lys Ala Val Pro Ile Glu 
    130                 135                 140                 

Ile Glu Leu Pro Leu Asn Asp Val Val Asp Ala His Val Tyr Pro Lys 
145                 150                 155                 160 

Asn Thr Glu Ala Lys Pro Lys Ile Asp Lys Asp Phe Lys Gly Lys Ala 
                165                 170                 175     

Asn Pro Asp Thr Pro Arg Val Asp Lys Asp Thr Pro Val Asn His Gln 
            180                 185                 190         

Val Gly Asp Val Val Glu Tyr Glu Ile Val Thr Lys Ile Pro Ala Leu 
        195                 200                 205             

Ala Asn Tyr Ala Thr Ala Asn Trp Ser Asp Arg Met Thr Glu Gly Leu 
    210                 215                 220                 

Ala Phe Asn Lys Gly Thr Val Lys Val Thr Val Asp Asp Val Ala Leu 
225                 230                 235                 240 

Glu Ala Gly Asp Tyr Ala Leu Thr Glu Val Ala Thr Gly Phe Asp Leu 
                245                 250                 255     

Lys Leu Thr Asp Ala Gly Leu Ala Lys Val Asn Asp Gln Asn Ala Glu 
            260                 265                 270         

Lys Thr Val Lys Ile Thr Tyr Ser Ala Thr Leu Asn Asp Lys Ala Ile 
        275                 280                 285             

Val Glu Val Pro Glu Ser Asn Asp Val Thr Phe Asn Tyr Gly Asn Asn 
    290                 295                 300                 

Pro Asp His Gly Asn Thr Pro Lys Pro Asn Lys Pro Asn Glu Asn Gly 
305                 310                 315                 320 

Asp Leu Thr Leu Thr Lys Thr Trp Val Asp Ala Thr Gly Ala Pro Ile 
                325                 330                 335     

Pro Ala Gly Ala Glu Ala Thr Phe Asp Leu Val Asn Ala Gln Thr Gly 
            340                 345                 350         

Lys Val Val Gln Thr Val Thr Leu Thr Thr Asp Lys Asn Thr Val Thr 
        355                 360                 365             

Val Asn Gly Leu Asp Lys Asn Thr Glu Tyr Lys Phe Val Glu Arg Ser 
    370                 375                 380                 

Ile Lys Gly Tyr Ser Ala Asp Tyr Gln Glu Ile Thr Thr Ala Gly Glu 
385                 390                 395                 400 

Ile Ala Val Lys Asn Trp Lys Asp Glu Asn Pro Lys Pro Leu Asp Pro 
                405                 410                 415     

Thr Glu Pro Lys Val Val Thr Tyr Gly Lys Lys Phe Val Lys Val Asn 
            420                 425                 430         

Asp Lys Asp Asn Arg Leu Ala Gly Ala Glu Phe Val Ile Ala Asn Ala 
        435                 440                 445             

Asp Asn Ala Gly Gln Tyr Leu Ala Arg Lys Ala Asp Lys Val Ser Gln 
    450                 455                 460                 

Glu Glu Lys Gln Leu Val Val Thr Thr Lys Asp Ala Leu Asp Arg Ala 
465                 470                 475                 480 

Val Ala Ala Tyr Asn Ala Leu Thr Ala Gln Gln Gln Thr Gln Gln Glu 
                485                 490                 495     

Lys Glu Lys Val Asp Lys Ala Gln Ala Ala Tyr Asn Ala Ala Val Ile 
            500                 505                 510         

Ala Ala Asn Asn Ala Phe Glu Trp Val Ala Asp Lys Asp Asn Glu Asn 
        515                 520                 525             

Val Val Lys Leu Val Ser Asp Ala Gln Gly Arg Phe Glu Ile Thr Gly 
    530                 535                 540                 

Leu Leu Ala Gly Thr Tyr Tyr Leu Glu Glu Thr Lys Gln Pro Ala Gly 
545                 550                 555                 560 

Tyr Ala Leu Leu Thr Ser Arg Gln Lys Phe Glu Val Thr Ala Thr Ser 
                565                 570                 575     

Tyr Ser Ala Thr Gly Gln Gly Ile Glu Tyr Thr Ala Gly Ser Gly Lys 
            580                 585                 590         

Asp Asp Ala Thr Lys Val Val Asn Lys Lys Ile Thr 
        595                 600                 

<210>   240
<211>   583
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   Fragment of SEQ ID NO: 237

<400>   240
Ala Ala Thr Val Phe Ala Ala Asp Asn Val Ser Thr Ala Pro Asp Ala 
1               5                   10                  15      

Val Thr Lys Thr Leu Thr Ile His Lys Leu Leu Leu Ser Glu Asp Asp 
            20                  25                  30          

Leu Lys Thr Trp Asp Thr Asn Gly Pro Lys Gly Tyr Asp Gly Thr Gln 
        35                  40                  45              

Ser Ser Leu Lys Asp Leu Thr Gly Val Val Ala Glu Glu Ile Pro Asn 
    50                  55                  60                  

Val Tyr Phe Glu Leu Gln Lys Tyr Asn Leu Thr Asp Gly Lys Glu Lys 
65                  70                  75                  80  

Glu Asn Leu Lys Asp Asp Ser Lys Trp Thr Thr Val His Gly Gly Leu 
                85                  90                  95      

Thr Thr Lys Asp Gly Leu Lys Ile Glu Thr Ser Thr Leu Lys Gly Val 
            100                 105                 110         

Tyr Arg Ile Arg Glu Asp Arg Thr Lys Thr Thr Tyr Val Gly Pro Asn 
        115                 120                 125             

Gly Gln Val Leu Thr Gly Ser Lys Ala Val Pro Ala Leu Val Thr Leu 
    130                 135                 140                 

Pro Leu Val Asn Asn Asn Gly Thr Val Ile Asp Ala His Val Phe Pro 
145                 150                 155                 160 

Lys Asn Ser Tyr Asn Lys Pro Val Val Asp Lys Arg Ile Ala Asp Thr 
                165                 170                 175     

Leu Asn Tyr Asn Asp Gln Asn Gly Leu Ser Ile Gly Thr Lys Ile Pro 
            180                 185                 190         

Tyr Val Val Asn Thr Thr Ile Pro Ser Asn Ala Thr Phe Ala Thr Ser 
        195                 200                 205             

Phe Trp Ser Asp Glu Met Thr Glu Gly Leu Thr Tyr Asn Glu Asp Val 
    210                 215                 220                 

Thr Ile Thr Leu Asn Asn Val Ala Met Asp Gln Ala Asp Tyr Glu Val 
225                 230                 235                 240 

Thr Lys Gly Asn Asn Gly Phe Asn Leu Lys Leu Thr Glu Ala Gly Leu 
                245                 250                 255     

Ala Lys Ile Asn Gly Lys Asp Ala Asp Gln Lys Ile Gln Ile Thr Tyr 
            260                 265                 270         

Ser Ala Thr Leu Asn Ser Leu Ala Val Ala Asp Ile Pro Glu Ser Asn 
        275                 280                 285             

Asp Ile Thr Tyr His Tyr Gly Asn His Gln Asp His Gly Asn Thr Pro 
    290                 295                 300                 

Lys Pro Thr Lys Pro Asn Asn Gly Gln Ile Thr Val Thr Lys Thr Trp 
305                 310                 315                 320 

Asp Ser Gln Pro Ala Pro Glu Gly Val Lys Ala Thr Val Gln Leu Val 
                325                 330                 335     

Asn Ala Lys Thr Gly Glu Lys Val Gly Ala Pro Val Glu Leu Ser Glu 
            340                 345                 350         

Asn Asn Trp Thr Tyr Thr Trp Ser Gly Leu Asp Asn Ser Ile Glu Tyr 
        355                 360                 365             

Lys Val Glu Glu Glu Tyr Asn Gly Tyr Ser Ala Glu Tyr Thr Val Glu 
    370                 375                 380                 

Ser Lys Gly Lys Leu Gly Val Lys Asn Trp Lys Asp Asn Asn Pro Ala 
385                 390                 395                 400 

Pro Ile Asn Pro Glu Glu Pro Arg Val Lys Thr Tyr Gly Lys Lys Phe 
                405                 410                 415     

Val Lys Val Asp Gln Lys Asp Thr Arg Leu Glu Asn Ala Gln Phe Val 
            420                 425                 430         

Val Lys Lys Ala Asp Ser Asn Lys Tyr Ile Ala Phe Lys Ser Thr Ala 
        435                 440                 445             

Gln Gln Ala Ala Asp Glu Lys Ala Ala Ala Thr Ala Lys Gln Lys Leu 
    450                 455                 460                 

Asp Ala Ala Val Ala Ala Tyr Thr Asn Ala Ala Asp Lys Gln Ala Ala 
465                 470                 475                 480 

Gln Ala Leu Val Asp Gln Ala Gln Gln Glu Tyr Asn Val Ala Tyr Lys 
                485                 490                 495     

Glu Ala Lys Phe Gly Tyr Val Glu Val Ala Gly Lys Asp Glu Ala Met 
            500                 505                 510         

Val Leu Thr Ser Asn Thr Asp Gly Gln Phe Gln Ile Ser Gly Leu Ala 
        515                 520                 525             

Ala Gly Thr Tyr Lys Leu Glu Glu Ile Lys Ala Pro Glu Gly Phe Ala 
    530                 535                 540                 

Lys Ile Asp Asp Val Glu Phe Val Val Gly Ala Gly Ser Trp Asn Gln 
545                 550                 555                 560 

Gly Glu Phe Asn Tyr Leu Lys Asp Val Gln Lys Asn Asp Ala Thr Lys 
                565                 570                 575     

Val Val Asn Lys Lys Ile Thr 
            580             

<210>   241
<211>   587
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   Fragment of SEQ ID NO: 238

<400>   241
Ala Glu Gln Lys Thr Lys Thr Leu Thr Val His Lys Leu Leu Met Thr 
1               5                   10                  15      

Asp Gln Glu Leu Asp Ala Trp Asn Ser Asp Ala Ile Thr Thr Ala Gly 
            20                  25                  30          

Tyr Asp Gly Ser Gln Asn Phe Glu Gln Phe Lys Gln Leu Gln Gly Val 
        35                  40                  45              

Pro Gln Gly Val Thr Glu Ile Ser Gly Val Ala Phe Glu Leu Gln Ser 
    50                  55                  60                  

Tyr Thr Gly Pro Gln Gly Lys Glu Gln Glu Asn Leu Thr Asn Asp Ala 
65                  70                  75                  80  

Val Trp Thr Ala Val Asn Lys Gly Val Thr Thr Glu Thr Gly Val Lys 
                85                  90                  95      

Phe Asp Thr Glu Val Leu Gln Gly Thr Tyr Arg Leu Val Glu Val Arg 
            100                 105                 110         

Lys Glu Ser Thr Tyr Val Gly Pro Asn Gly Lys Val Leu Thr Gly Met 
        115                 120                 125             

Lys Ala Val Pro Ala Leu Ile Thr Leu Pro Leu Val Asn Gln Asn Gly 
    130                 135                 140                 

Val Val Glu Asn Ala His Val Tyr Pro Lys Asn Ser Glu Asp Lys Pro 
145                 150                 155                 160 

Thr Ala Thr Lys Thr Phe Asp Thr Ala Ala Gly Phe Val Asp Pro Gly 
                165                 170                 175     

Glu Lys Gly Leu Ala Ile Gly Thr Lys Val Pro Tyr Ile Val Thr Thr 
            180                 185                 190         

Thr Ile Pro Lys Asn Ser Thr Leu Ala Thr Ala Phe Trp Ser Asp Glu 
        195                 200                 205             

Met Thr Glu Gly Leu Asp Tyr Asn Gly Asp Val Val Val Asn Tyr Asn 
    210                 215                 220                 

Gly Gln Pro Leu Asp Asn Ser His Tyr Thr Leu Glu Ala Gly His Asn 
225                 230                 235                 240 

Gly Phe Ile Leu Lys Leu Asn Glu Lys Gly Leu Glu Ala Ile Asn Gly 
                245                 250                 255     

Lys Asp Ala Glu Ala Thr Ile Thr Leu Lys Tyr Thr Ala Thr Leu Asn 
            260                 265                 270         

Ala Leu Ala Val Ala Asp Val Pro Glu Ala Asn Asp Val Thr Phe His 
        275                 280                 285             

Tyr Gly Asn Asn Pro Gly His Gly Asn Thr Pro Lys Pro Asn Lys Pro 
    290                 295                 300                 

Lys Asn Gly Glu Leu Thr Ile Thr Lys Thr Trp Ala Asp Ala Lys Asp 
305                 310                 315                 320 

Ala Pro Ile Ala Gly Val Glu Val Thr Phe Asp Leu Val Asn Ala Gln 
                325                 330                 335     

Thr Gly Glu Val Val Lys Val Pro Gly His Glu Thr Gly Ile Val Leu 
            340                 345                 350         

Asn Gln Thr Asn Asn Trp Thr Phe Thr Ala Thr Gly Leu Asp Asn Asn 
        355                 360                 365             

Thr Glu Tyr Lys Phe Val Glu Arg Thr Ile Lys Gly Tyr Ser Ala Asp 
    370                 375                 380                 

Tyr Gln Thr Ile Thr Glu Thr Gly Lys Ile Ala Val Lys Asn Trp Lys 
385                 390                 395                 400 

Asp Glu Asn Pro Glu Pro Ile Asn Pro Glu Glu Pro Arg Val Lys Thr 
                405                 410                 415     

Tyr Gly Lys Lys Phe Val Lys Val Asp Gln Lys Asp Glu Arg Leu Lys 
            420                 425                 430         

Glu Ala Gln Phe Val Val Lys Asn Glu Gln Gly Lys Tyr Leu Ala Leu 
        435                 440                 445             

Lys Ser Ala Ala Gln Gln Ala Val Asn Glu Lys Ala Ala Ala Glu Ala 
    450                 455                 460                 

Lys Gln Ala Leu Asp Ala Ala Ile Ala Ala Tyr Thr Asn Ala Ala Asp 
465                 470                 475                 480 

Lys Asn Ala Ala Gln Ala Val Val Asp Ala Ala Gln Lys Thr Tyr Asn 
                485                 490                 495     

Asp Asn Tyr Arg Ala Ala Arg Phe Gly Tyr Val Glu Val Glu Arg Lys 
            500                 505                 510         

Glu Asp Ala Leu Val Leu Thr Ser Asn Thr Asp Gly Gln Phe Gln Ile 
        515                 520                 525             

Ser Gly Leu Ala Ala Gly Ser Tyr Thr Leu Glu Glu Thr Lys Ala Pro 
    530                 535                 540                 

Glu Gly Phe Ala Lys Leu Gly Asp Val Lys Phe Glu Val Gly Ala Gly 
545                 550                 555                 560 

Ser Trp Asn Gln Gly Asp Phe Asn Tyr Leu Lys Asp Val Gln Lys Asn 
                565                 570                 575     

Asp Ala Thr Lys Val Val Asn Lys Lys Ile Thr 
            580                 585         

<210>   242
<211>   6
<212>   PRT
<213>   Artificial

<220>
<223>   linker amino acid sequence

<400>   242
Gly Ser Gly Gly Gly Gly 
1               5       

<210>   243
<211>   8
<212>   PRT
<213>   Artificial

<220>
<223>   linker amino acid sequence

<400>   243
Gly Ser Gly Ser Gly Gly Gly Gly 
1               5               

<210>   244
<211>   6
<212>   PRT
<213>   Artificial

<220>
<223>   hexa-His tag

<400>   244
His His His His His His 
1               5       

<210>   245
<211>   8
<212>   PRT
<213>   Artificial

<220>
<223>   linker

<400>   245
Leu Gly Gly Ser Gly Gly Gly Gly 
1               5               

<210>   246
<211>   1801
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   RrgB I-II-III

<400>   246
Met Ala Ser Ala Ala Thr Val Phe Ala Ala Gly Thr Thr Thr Thr Ser 
1               5                   10                  15      

Val Thr Val His Lys Leu Leu Ala Thr Asp Gly Asp Met Asp Lys Ile 
            20                  25                  30          

Ala Asn Glu Leu Glu Thr Gly Asn Tyr Ala Gly Asn Lys Val Gly Val 
        35                  40                  45              

Leu Pro Ala Asn Ala Lys Glu Ile Ala Gly Val Met Phe Val Trp Thr 
    50                  55                  60                  

Asn Thr Asn Asn Glu Ile Ile Asp Glu Asn Gly Gln Thr Leu Gly Val 
65                  70                  75                  80  

Asn Ile Asp Pro Gln Thr Phe Lys Leu Ser Gly Ala Met Pro Ala Thr 
                85                  90                  95      

Ala Met Lys Lys Leu Thr Glu Ala Glu Gly Ala Lys Phe Asn Thr Ala 
            100                 105                 110         

Asn Leu Pro Ala Ala Lys Tyr Lys Ile Tyr Glu Ile His Ser Leu Ser 
        115                 120                 125             

Thr Tyr Val Gly Glu Asp Gly Ala Thr Leu Thr Gly Ser Lys Ala Val 
    130                 135                 140                 

Pro Ile Glu Ile Glu Leu Pro Leu Asn Asp Val Val Asp Ala His Val 
145                 150                 155                 160 

Tyr Pro Lys Asn Thr Glu Ala Lys Pro Lys Ile Asp Lys Asp Phe Lys 
                165                 170                 175     

Gly Lys Ala Asn Pro Asp Thr Pro Arg Val Asp Lys Asp Thr Pro Val 
            180                 185                 190         

Asn His Gln Val Gly Asp Val Val Glu Tyr Glu Ile Val Thr Lys Ile 
        195                 200                 205             

Pro Ala Leu Ala Asn Tyr Ala Thr Ala Asn Trp Ser Asp Arg Met Thr 
    210                 215                 220                 

Glu Gly Leu Ala Phe Asn Lys Gly Thr Val Lys Val Thr Val Asp Asp 
225                 230                 235                 240 

Val Ala Leu Glu Ala Gly Asp Tyr Ala Leu Thr Glu Val Ala Thr Gly 
                245                 250                 255     

Phe Asp Leu Lys Leu Thr Asp Ala Gly Leu Ala Lys Val Asn Asp Gln 
            260                 265                 270         

Asn Ala Glu Lys Thr Val Lys Ile Thr Tyr Ser Ala Thr Leu Asn Asp 
        275                 280                 285             

Lys Ala Ile Val Glu Val Pro Glu Ser Asn Asp Val Thr Phe Asn Tyr 
    290                 295                 300                 

Gly Asn Asn Pro Asp His Gly Asn Thr Pro Lys Pro Asn Lys Pro Asn 
305                 310                 315                 320 

Glu Asn Gly Asp Leu Thr Leu Thr Lys Thr Trp Val Asp Ala Thr Gly 
                325                 330                 335     

Ala Pro Ile Pro Ala Gly Ala Glu Ala Thr Phe Asp Leu Val Asn Ala 
            340                 345                 350         

Gln Thr Gly Lys Val Val Gln Thr Val Thr Leu Thr Thr Asp Lys Asn 
        355                 360                 365             

Thr Val Thr Val Asn Gly Leu Asp Lys Asn Thr Glu Tyr Lys Phe Val 
    370                 375                 380                 

Glu Arg Ser Ile Lys Gly Tyr Ser Ala Asp Tyr Gln Glu Ile Thr Thr 
385                 390                 395                 400 

Ala Gly Glu Ile Ala Val Lys Asn Trp Lys Asp Glu Asn Pro Lys Pro 
                405                 410                 415     

Leu Asp Pro Thr Glu Pro Lys Val Val Thr Tyr Gly Lys Lys Phe Val 
            420                 425                 430         

Lys Val Asn Asp Lys Asp Asn Arg Leu Ala Gly Ala Glu Phe Val Ile 
        435                 440                 445             

Ala Asn Ala Asp Asn Ala Gly Gln Tyr Leu Ala Arg Lys Ala Asp Lys 
    450                 455                 460                 

Val Ser Gln Glu Glu Lys Gln Leu Val Val Thr Thr Lys Asp Ala Leu 
465                 470                 475                 480 

Asp Arg Ala Val Ala Ala Tyr Asn Ala Leu Thr Ala Gln Gln Gln Thr 
                485                 490                 495     

Gln Gln Glu Lys Glu Lys Val Asp Lys Ala Gln Ala Ala Tyr Asn Ala 
            500                 505                 510         

Ala Val Ile Ala Ala Asn Asn Ala Phe Glu Trp Val Ala Asp Lys Asp 
        515                 520                 525             

Asn Glu Asn Val Val Lys Leu Val Ser Asp Ala Gln Gly Arg Phe Glu 
    530                 535                 540                 

Ile Thr Gly Leu Leu Ala Gly Thr Tyr Tyr Leu Glu Glu Thr Lys Gln 
545                 550                 555                 560 

Pro Ala Gly Tyr Ala Leu Leu Thr Ser Arg Gln Lys Phe Glu Val Thr 
                565                 570                 575     

Ala Thr Ser Tyr Ser Ala Thr Gly Gln Gly Ile Glu Tyr Thr Ala Gly 
            580                 585                 590         

Ser Gly Lys Asp Asp Ala Thr Lys Val Val Asn Lys Lys Ile Thr Gly 
        595                 600                 605             

Ser Gly Ser Gly Gly Gly Gly Ala Ala Thr Val Phe Ala Ala Asp Asn 
    610                 615                 620                 

Val Ser Thr Ala Pro Asp Ala Val Thr Lys Thr Leu Thr Ile His Lys 
625                 630                 635                 640 

Leu Leu Leu Ser Glu Asp Asp Leu Lys Thr Trp Asp Thr Asn Gly Pro 
                645                 650                 655     

Lys Gly Tyr Asp Gly Thr Gln Ser Ser Leu Lys Asp Leu Thr Gly Val 
            660                 665                 670         

Val Ala Glu Glu Ile Pro Asn Val Tyr Phe Glu Leu Gln Lys Tyr Asn 
        675                 680                 685             

Leu Thr Asp Gly Lys Glu Lys Glu Asn Leu Lys Asp Asp Ser Lys Trp 
    690                 695                 700                 

Thr Thr Val His Gly Gly Leu Thr Thr Lys Asp Gly Leu Lys Ile Glu 
705                 710                 715                 720 

Thr Ser Thr Leu Lys Gly Val Tyr Arg Ile Arg Glu Asp Arg Thr Lys 
                725                 730                 735     

Thr Thr Tyr Val Gly Pro Asn Gly Gln Val Leu Thr Gly Ser Lys Ala 
            740                 745                 750         

Val Pro Ala Leu Val Thr Leu Pro Leu Val Asn Asn Asn Gly Thr Val 
        755                 760                 765             

Ile Asp Ala His Val Phe Pro Lys Asn Ser Tyr Asn Lys Pro Val Val 
    770                 775                 780                 

Asp Lys Arg Ile Ala Asp Thr Leu Asn Tyr Asn Asp Gln Asn Gly Leu 
785                 790                 795                 800 

Ser Ile Gly Thr Lys Ile Pro Tyr Val Val Asn Thr Thr Ile Pro Ser 
                805                 810                 815     

Asn Ala Thr Phe Ala Thr Ser Phe Trp Ser Asp Glu Met Thr Glu Gly 
            820                 825                 830         

Leu Thr Tyr Asn Glu Asp Val Thr Ile Thr Leu Asn Asn Val Ala Met 
        835                 840                 845             

Asp Gln Ala Asp Tyr Glu Val Thr Lys Gly Asn Asn Gly Phe Asn Leu 
    850                 855                 860                 

Lys Leu Thr Glu Ala Gly Leu Ala Lys Ile Asn Gly Lys Asp Ala Asp 
865                 870                 875                 880 

Gln Lys Ile Gln Ile Thr Tyr Ser Ala Thr Leu Asn Ser Leu Ala Val 
                885                 890                 895     

Ala Asp Ile Pro Glu Ser Asn Asp Ile Thr Tyr His Tyr Gly Asn His 
            900                 905                 910         

Gln Asp His Gly Asn Thr Pro Lys Pro Thr Lys Pro Asn Asn Gly Gln 
        915                 920                 925             

Ile Thr Val Thr Lys Thr Trp Asp Ser Gln Pro Ala Pro Glu Gly Val 
    930                 935                 940                 

Lys Ala Thr Val Gln Leu Val Asn Ala Lys Thr Gly Glu Lys Val Gly 
945                 950                 955                 960 

Ala Pro Val Glu Leu Ser Glu Asn Asn Trp Thr Tyr Thr Trp Ser Gly 
                965                 970                 975     

Leu Asp Asn Ser Ile Glu Tyr Lys Val Glu Glu Glu Tyr Asn Gly Tyr 
            980                 985                 990         

Ser Ala Glu Tyr Thr Val Glu Ser Lys Gly Lys Leu Gly Val Lys Asn 
        995                 1000                1005            

Trp Lys Asp Asn Asn Pro Ala Pro Ile Asn Pro Glu Glu Pro Arg Val 
    1010                1015                1020                

Lys Thr Tyr Gly Lys Lys Phe Val Lys Val Asp Gln Lys Asp Thr Arg 
1025                1030                1035                1040

Leu Glu Asn Ala Gln Phe Val Val Lys Lys Ala Asp Ser Asn Lys Tyr 
                1045                1050                1055    

Ile Ala Phe Lys Ser Thr Ala Gln Gln Ala Ala Asp Glu Lys Ala Ala 
            1060                1065                1070        

Ala Thr Ala Lys Gln Lys Leu Asp Ala Ala Val Ala Ala Tyr Thr Asn 
        1075                1080                1085            

Ala Ala Asp Lys Gln Ala Ala Gln Ala Leu Val Asp Gln Ala Gln Gln 
    1090                1095                1100                

Glu Tyr Asn Val Ala Tyr Lys Glu Ala Lys Phe Gly Tyr Val Glu Val 
1105                1110                1115                1120

Ala Gly Lys Asp Glu Ala Met Val Leu Thr Ser Asn Thr Asp Gly Gln 
                1125                1130                1135    

Phe Gln Ile Ser Gly Leu Ala Ala Gly Thr Tyr Lys Leu Glu Glu Ile 
            1140                1145                1150        

Lys Ala Pro Glu Gly Phe Ala Lys Ile Asp Asp Val Glu Phe Val Val 
        1155                1160                1165            

Gly Ala Gly Ser Trp Asn Gln Gly Glu Phe Asn Tyr Leu Lys Asp Val 
    1170                1175                1180                

Gln Lys Asn Asp Ala Thr Lys Val Val Asn Lys Lys Ile Thr Leu Gly 
1185                1190                1195                1200

Gly Ser Gly Gly Gly Gly Ala Glu Gln Lys Thr Lys Thr Leu Thr Val 
                1205                1210                1215    

His Lys Leu Leu Met Thr Asp Gln Glu Leu Asp Ala Trp Asn Ser Asp 
            1220                1225                1230        

Ala Ile Thr Thr Ala Gly Tyr Asp Gly Ser Gln Asn Phe Glu Gln Phe 
        1235                1240                1245            

Lys Gln Leu Gln Gly Val Pro Gln Gly Val Thr Glu Ile Ser Gly Val 
    1250                1255                1260                

Ala Phe Glu Leu Gln Ser Tyr Thr Gly Pro Gln Gly Lys Glu Gln Glu 
1265                1270                1275                1280

Asn Leu Thr Asn Asp Ala Val Trp Thr Ala Val Asn Lys Gly Val Thr 
                1285                1290                1295    

Thr Glu Thr Gly Val Lys Phe Asp Thr Glu Val Leu Gln Gly Thr Tyr 
            1300                1305                1310        

Arg Leu Val Glu Val Arg Lys Glu Ser Thr Tyr Val Gly Pro Asn Gly 
        1315                1320                1325            

Lys Val Leu Thr Gly Met Lys Ala Val Pro Ala Leu Ile Ile Leu Pro 
    1330                1335                1340                

Leu Val Asn Gln Asn Gly Val Val Glu Asn Ala His Val Tyr Pro Lys 
1345                1350                1355                1360

Asn Ser Glu Asp Lys Pro Thr Ala Thr Lys Thr Phe Asp Thr Ala Ala 
                1365                1370                1375    

Gly Phe Val Asp Pro Gly Glu Lys Gly Leu Ala Ile Gly Thr Lys Val 
            1380                1385                1390        

Pro Tyr Ile Val Thr Thr Thr Ile Pro Lys Asn Ser Thr Leu Ala Thr 
        1395                1400                1405            

Ala Phe Trp Ser Asp Glu Met Thr Glu Gly Leu Asp Tyr Asn Gly Asp 
    1410                1415                1420                

Val Val Val Asn Tyr Asn Gly Gln Pro Leu Asp Asn Ser His Tyr Thr 
1425                1430                1435                1440

Leu Glu Ala Gly His Asn Gly Phe Ile Leu Lys Leu Asn Glu Lys Gly 
                1445                1450                1455    

Leu Glu Ala Ile Asn Gly Lys Asp Ala Glu Ala Thr Ile Thr Leu Lys 
            1460                1465                1470        

Tyr Thr Ala Thr Leu Asn Ala Leu Ala Val Ala Asp Val Pro Glu Ala 
        1475                1480                1485            

Asn Asp Val Thr Phe His Tyr Gly Asn Asn Pro Gly His Gly Asn Thr 
    1490                1495                1500                

Pro Lys Pro Asn Lys Pro Lys Asn Gly Glu Leu Thr Ile Thr Lys Thr 
1505                1510                1515                1520

Trp Ala Asp Ala Lys Asp Ala Pro Ile Ala Gly Val Glu Val Thr Phe 
                1525                1530                1535    

Asp Leu Val Asn Ala Gln Thr Gly Glu Val Val Lys Val Pro Gly His 
            1540                1545                1550        

Glu Thr Gly Ile Val Leu Asn Gln Thr Asn Asn Trp Thr Phe Thr Ala 
        1555                1560                1565            

Thr Gly Leu Asp Asn Asn Thr Glu Tyr Lys Phe Val Glu Arg Thr Ile 
    1570                1575                1580                

Lys Gly Tyr Ser Ala Asp Tyr Gln Thr Ile Thr Glu Thr Gly Lys Ile 
1585                1590                1595                1600

Ala Val Lys Asn Trp Lys Asp Glu Asn Pro Glu Pro Ile Asn Pro Glu 
                1605                1610                1615    

Glu Pro Arg Val Lys Thr Tyr Gly Lys Lys Phe Val Lys Val Asp Gln 
            1620                1625                1630        

Lys Asp Glu Arg Leu Lys Glu Ala Gln Phe Val Val Lys Asn Glu Gln 
        1635                1640                1645            

Gly Lys Tyr Leu Ala Leu Lys Ser Ala Ala Gln Gln Ala Val Asn Glu 
    1650                1655                1660                

Lys Ala Ala Ala Glu Ala Lys Gln Ala Leu Asp Ala Ala Ile Ala Ala 
1665                1670                1675                1680

Tyr Thr Asn Ala Ala Asp Lys Asn Ala Ala Gln Ala Val Val Asp Ala 
                1685                1690                1695    

Ala Gln Lys Thr Tyr Asn Asp Asn Tyr Arg Ala Ala Arg Phe Gly Tyr 
            1700                1705                1710        

Val Glu Val Glu Arg Lys Glu Asp Ala Leu Val Leu Thr Ser Asn Thr 
        1715                1720                1725            

Asp Gly Gln Phe Gln Ile Ser Gly Leu Ala Ala Gly Ser Tyr Thr Leu 
    1730                1735                1740                

Glu Glu Thr Lys Ala Pro Glu Gly Phe Ala Lys Leu Gly Asp Val Lys 
1745                1750                1755                1760

Phe Glu Val Gly Ala Gly Ser Trp Asn Gln Gly Asp Phe Asn Tyr Leu 
                1765                1770                1775    

Lys Asp Val Gln Lys Asn Asp Ala Thr Lys Val Val Asn Lys Lys Ile 
            1780                1785                1790        

Thr Leu Gly His His His His His His 
        1795                1800    

<210>   247
<211>   5403
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Sequence encoding SEQ ID NO: 246

<400>   247
atggctagcg ctgcaacagt ttttgcggct gggacgacaa caacatctgt taccgttcat   60
aaactattgg caacagatgg ggatatggat aaaattgcaa atgagttaga aacaggtaac   120
tatgctggta ataaagtggg tgttctacct gcaaatgcaa aagaaattgc cggtgttatg   180
ttcgtttgga caaatactaa taatgaaatt attgatgaaa atggccaaac tctaggagtg   240
aatattgatc cacaaacatt taaactctca ggggcaatgc cggcaactgc aatgaaaaaa   300
ttaacagaag ctgaaggagc taaatttaac acggcaaatt taccagctgc taagtataaa   360
atttatgaaa ttcacagttt atcaacttat gtcggtgaag atggagcaac cttaacaggt   420
tctaaagcag ttccaattga aattgaatta ccattgaacg atgttgtgga tgcgcatgtg   480
tatccaaaaa atacagaagc aaagccaaaa attgataaag atttcaaagg taaagcaaat   540
ccagatacac cacgtgtaga taaagataca cctgtgaacc accaagttgg agatgttgta   600
gagtacgaaa ttgttacaaa aattccagca cttgctaatt atgcaacagc aaactggagc   660
gatagaatga ctgaaggttt ggcattcaac aaaggtacag tgaaagtaac tgttgatgat   720
gttgcacttg aagcaggtga ttatgctcta acagaagtag caactggttt tgatttgaaa   780
ttaacagatg ctggtttagc taaagtgaat gaccaaaacg ctgaaaaaac tgtgaaaatc   840
acttattcgg caacattgaa tgacaaagca attgtagaag taccagaatc taatgatgta   900
acatttaact atggtaataa tccagatcac gggaatactc caaagccgaa taagccaaat   960
gaaaacggcg atttgacatt gaccaagaca tgggttgatg ctacaggtgc accaattccg   1020
gctggagctg aagcaacgtt cgatttggtt aatgctcaga ctggtaaagt tgtacaaact   1080
gtaactttga caacagacaa aaatacagtt actgttaacg gattggataa aaatacagaa   1140
tataaattcg ttgaacgtag tataaaaggg tattcagcag attatcaaga aatcactaca   1200
gctggagaaa ttgctgtcaa gaactggaaa gacgaaaatc caaaaccact tgatccaaca   1260
gagccaaaag ttgttacata tggtaaaaag tttgtcaaag ttaatgataa agataatcgt   1320
ttagctgggg cagaatttgt aattgcaaat gctgataatg ctggtcaata tttagcacgt   1380
aaagcagata aagtgagtca agaagagaag cagttggttg ttacaacaaa ggatgcttta   1440
gatagagcag ttgctgctta taacgctctt actgcacaac aacaaactca gcaagaaaaa   1500
gagaaagttg acaaagctca agctgcttat aatgctgctg tgattgctgc caacaatgca   1560
tttgaatggg tggcagataa ggacaatgaa aatgttgtga aattagtttc tgatgcacaa   1620
ggtcgctttg aaattacagg ccttcttgca ggtacatatt acttagaaga aacaaaacag   1680
cctgctggtt atgcattact aactagccgt cagaaatttg aagtcactgc aacttcttat   1740
tcagcgactg gacaaggcat tgagtatact gctggttcag gtaaagatga cgctacaaaa   1800
gtagtcaaca aaaaaatcac tggatccggc agcggtggcg gtggcgctgc aacagttttt   1860
gcggcggaca atgttagtac agcaccagat gctgttacta aaactttaac aatccataag   1920
ttactgctct cagaagatga tttaaagact tgggatacaa acggtcctaa aggatatgat   1980
ggaactcaat ctagtttaaa agatttaact ggagttgtag ctgaggaaat tccaaatgta   2040
tactttgaat tacaaaagta taatttgact gatggtaagg aaaaagaaaa tcttaaagat   2100
gatagtaaat ggacaacagt tcatggtggt ttgacaacta aagatggact taaaattgaa   2160
accagtactc ttaaaggtgt gtatcgtatt cgtgaggata gaacaaagac tacctatgtt   2220
ggtcctaatg ggcaagtatt aacaggttca aaagccgtac ctgctcttgt aactcttcca   2280
cttgttaaca ataatggtac agtaattgat gcacatgttt tccctaaaaa ttcatataat   2340
aaaccagttg tagataaaag aattgctgat actttgaatt ataacgatca aaatggtctg   2400
tctatcggta ctaaaatccc atatgttgtt aatacaacaa ttccaagtaa tgcaacattt   2460
gcaacttcat tttggtcaga tgaaatgaca gaaggtctaa cttataatga agatgtaaca   2520
attactttga ataatgtagc tatggatcaa gctgattatg aagtcactaa aggaaataat   2580
ggctttaact taaaattaac agaagcaggt ttagctaaaa ttaatggtaa ggatgcagac   2640
caaaaaatcc aaattactta ctcagctact ttgaactcac ttgctgttgc agacattcct   2700
gaaagtaacg atattacata tcattacgga aatcatcaag atcatgggaa tactccaaaa   2760
ccaactaaac ctaataatgg tcaaattaca gtaactaaga catgggacag tcaacctgct   2820
cctgaggggg tgaaagcgac tgttcaactt gtaaatgcca agactggtga gaaagtcggt   2880
gctcctgtag aactttcaga aaataattgg acatatactt ggagtggtct agataattct   2940
attgaataca aagttgaaga agaatataat ggatactcag ctgaatacac agtagagagc   3000
aaagggaagt tgggggtaaa aaactggaaa gataataacc cagctccaat caatcctgaa   3060
gaaccacgtg taaaaacata cggtaaaaag tttgtcaaag tagaccaaaa agatactcgt   3120
ctagaaaatg cgcagttcgt tgttaaaaaa gcagatagca ataaatatat tgcctttaag   3180
tcaactgcac aacaagctgc agatgaaaaa gcagcagcaa ctgcaaaaca aaaattggat   3240
gcagcggtag cagcttacac aaatgctgca gataagcaag ccgctcaagc tctagtagat   3300
caagcacagc aagaatacaa tgtagcttac aaagaagcca aatttggtta tgttgaagta   3360
gctggaaaag atgaagcaat ggttcttact tctaatacgg atggtcaatt ccaaatttca   3420
ggtcttgctg ctggtactta taaattagaa gaaattaaag ctccagaagg ttttgcgaaa   3480
attgatgatg tagaatttgt tgttggagca ggttcttgga atcaaggtga gtttaattac   3540
ttaaaagatg ttcaaaagaa tgacgctaca aaagtagtca acaaaaaaat cactctcgag   3600
ggcagcggtg gcggtggcgc ggaacaaaaa actaagacac ttacagttca taaattattg   3660
atgacagatc aagagcttga cgcttggaat tctgatgcga ttactactgc aggttatgac   3720
ggttcgcaaa attttgaaca gttcaaacaa cttcaaggtg ttccacaagg agtaaccgaa   3780
atctctggtg ttgcattcga gttacagagt tatacgggtc ctcaaggaaa agaacaagaa   3840
aatttaacga atgatgcggt ttggactgcg gttaataaag gtgtgacgac tgaaacgggt   3900
gttaaatttg atactgaagt tttacaaggg acatatcgtc ttgtcgaagt acgtaaagaa   3960
tcgacttatg tcggtccaaa tggtaaagtt ttaacaggta tgaaagctgt tcctgcttta   4020
attattctgc cgcttgtaaa ccaaaatggt gttgtagaaa atgcacatgt ctatccaaag   4080
aattctgaag acaaacctac agcaacgaaa acatttgata ctgcagcagg tttcgtagat   4140
ccaggtgaaa aaggtttagc aattggcact aaggtaccgt atattgttac aacaactatt   4200
ccgaaaaact caactcttgc aacagctttc tggtcagatg aaatgacaga aggtctagat   4260
tataatggtg atgtagttgt taattataat ggtcaaccgc ttgataattc tcattacaca   4320
ttagaagcag gtcataatgg ctttatcttg aagttaaatg aaaaaggtct ggaagcaatc   4380
aacggtaaag atgcagaagc aacaattacg ttgaagtata ctgcaacttt aaatgctctt   4440
gctgttgctg atgtgccaga agcgaatgat gtaacattcc attatggaaa caacccaggt   4500
catggtaaca ctccaaaacc aaacaaacct aaaaacggtg aacttacaat tactaaaaca   4560
tgggctgatg ctaaagatgc tcctatagca ggtgtagaag taacttttga tttggtaaat   4620
gctcagacag gtgaggtcgt taaagtacct ggacatgaaa caggtattgt attgaatcaa   4680
acaaataatt ggacatttac tgctacaggt cttgataata atacagaata taaatttgtt   4740
gaacggacaa ttaagggata ttctgcagat taccaaacaa ttactgaaac aggaaaaatt   4800
gctgttaaaa actggaaaga tgaaaatcca gaaccaataa atcctgaaga gccacgtgta   4860
aaaacatatg gtaaaaaatt cgttaaggtt gaccaaaaag acgaacgctt aaaagaagca   4920
caattcgttg tgaagaatga gcaagggaaa tatcttgcac tcaaatctgc agcacaacaa   4980
gctgtaaatg agaaagctgc cgcagaagcg aaacaagcgc tagatgcagc gatagcagcc   5040
tatacaaatg ctgcagataa aaatgcagca caagctgtag tagatgctgc gcaaaaaaca   5100
tataatgaca attacagagc agctagattt ggctatgtag aagtagagag aaaagaagat   5160
gcgttagttc ttacttctaa cactgatggt caattccaaa tttcaggtct tgctgctgga   5220
agctacacgt tggaagaaac aaaagctcca gaaggctttg caaaacttgg agatgtgaag   5280
tttgaggttg gagcaggttc ttggaatcaa ggtgatttca attatttaaa agatgttcag   5340
aagaacgacg ctacaaaagt agtcaacaaa aaaatcacgc tcgagcacca ccaccaccac   5400
cac                                                                 5403

<210>   248
<211>   1801
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   RrgB I-III-II

<400>   248
Met Ala Ser Ala Ala Thr Val Phe Ala Ala Gly Thr Thr Thr Thr Ser 
1               5                   10                  15      

Val Thr Val His Lys Leu Leu Ala Thr Asp Gly Asp Met Asp Lys Ile 
            20                  25                  30          

Ala Asn Glu Leu Glu Thr Gly Asn Tyr Ala Gly Asn Lys Val Gly Val 
        35                  40                  45              

Leu Pro Ala Asn Ala Lys Glu Ile Ala Gly Val Met Phe Val Trp Thr 
    50                  55                  60                  

Asn Thr Asn Asn Glu Ile Ile Asp Glu Asn Gly Gln Thr Leu Gly Val 
65                  70                  75                  80  

Asn Ile Asp Pro Gln Thr Phe Lys Leu Ser Gly Ala Met Pro Ala Thr 
                85                  90                  95      

Ala Met Lys Lys Leu Thr Glu Ala Glu Gly Ala Lys Phe Asn Thr Ala 
            100                 105                 110         

Asn Leu Pro Ala Ala Lys Tyr Lys Ile Tyr Glu Ile His Ser Leu Ser 
        115                 120                 125             

Thr Tyr Val Gly Glu Asp Gly Ala Thr Leu Thr Gly Ser Lys Ala Val 
    130                 135                 140                 

Pro Ile Glu Ile Glu Leu Pro Leu Asn Asp Val Val Asp Ala His Val 
145                 150                 155                 160 

Tyr Pro Lys Asn Thr Glu Ala Lys Pro Lys Ile Asp Lys Asp Phe Lys 
                165                 170                 175     

Gly Lys Ala Asn Pro Asp Thr Pro Arg Val Asp Lys Asp Thr Pro Val 
            180                 185                 190         

Asn His Gln Val Gly Asp Val Val Glu Tyr Glu Ile Val Thr Lys Ile 
        195                 200                 205             

Pro Ala Leu Ala Asn Tyr Ala Thr Ala Asn Trp Ser Asp Arg Met Thr 
    210                 215                 220                 

Glu Gly Leu Ala Phe Asn Lys Gly Thr Val Lys Val Thr Val Asp Asp 
225                 230                 235                 240 

Val Ala Leu Glu Ala Gly Asp Tyr Ala Leu Thr Glu Val Ala Thr Gly 
                245                 250                 255     

Phe Asp Leu Lys Leu Thr Asp Ala Gly Leu Ala Lys Val Asn Asp Gln 
            260                 265                 270         

Asn Ala Glu Lys Thr Val Lys Ile Thr Tyr Ser Ala Thr Leu Asn Asp 
        275                 280                 285             

Lys Ala Ile Val Glu Val Pro Glu Ser Asn Asp Val Thr Phe Asn Tyr 
    290                 295                 300                 

Gly Asn Asn Pro Asp His Gly Asn Thr Pro Lys Pro Asn Lys Pro Asn 
305                 310                 315                 320 

Glu Asn Gly Asp Leu Thr Leu Thr Lys Thr Trp Val Asp Ala Thr Gly 
                325                 330                 335     

Ala Pro Ile Pro Ala Gly Ala Glu Ala Thr Phe Asp Leu Val Asn Ala 
            340                 345                 350         

Gln Thr Gly Lys Val Val Gln Thr Val Thr Leu Thr Thr Asp Lys Asn 
        355                 360                 365             

Thr Val Thr Val Asn Gly Leu Asp Lys Asn Thr Glu Tyr Lys Phe Val 
    370                 375                 380                 

Glu Arg Ser Ile Lys Gly Tyr Ser Ala Asp Tyr Gln Glu Ile Thr Thr 
385                 390                 395                 400 

Ala Gly Glu Ile Ala Val Lys Asn Trp Lys Asp Glu Asn Pro Lys Pro 
                405                 410                 415     

Leu Asp Pro Thr Glu Pro Lys Val Val Thr Tyr Gly Lys Lys Phe Val 
            420                 425                 430         

Lys Val Asn Asp Lys Asp Asn Arg Leu Ala Gly Ala Glu Phe Val Ile 
        435                 440                 445             

Ala Asn Ala Asp Asn Ala Gly Gln Tyr Leu Ala Arg Lys Ala Asp Lys 
    450                 455                 460                 

Val Ser Gln Glu Glu Lys Gln Leu Val Val Thr Thr Lys Asp Ala Leu 
465                 470                 475                 480 

Asp Arg Ala Val Ala Ala Tyr Asn Ala Leu Thr Ala Gln Gln Gln Thr 
                485                 490                 495     

Gln Gln Glu Lys Glu Lys Val Asp Lys Ala Gln Ala Ala Tyr Asn Ala 
            500                 505                 510         

Ala Val Ile Ala Ala Asn Asn Ala Phe Glu Trp Val Ala Asp Lys Asp 
        515                 520                 525             

Asn Glu Asn Val Val Lys Leu Val Ser Asp Ala Gln Gly Arg Phe Glu 
    530                 535                 540                 

Ile Thr Gly Leu Leu Ala Gly Thr Tyr Tyr Leu Glu Glu Thr Lys Gln 
545                 550                 555                 560 

Pro Ala Gly Tyr Ala Leu Leu Thr Ser Arg Gln Lys Phe Glu Val Thr 
                565                 570                 575     

Ala Thr Ser Tyr Ser Ala Thr Gly Gln Gly Ile Glu Tyr Thr Ala Gly 
            580                 585                 590         

Ser Gly Lys Asp Asp Ala Thr Lys Val Val Asn Lys Lys Ile Thr Gly 
        595                 600                 605             

Ser Gly Ser Gly Gly Gly Gly Ala Glu Gln Lys Thr Lys Thr Leu Thr 
    610                 615                 620                 

Val His Lys Leu Leu Met Thr Asp Gln Glu Leu Asp Ala Trp Asn Ser 
625                 630                 635                 640 

Asp Ala Ile Thr Thr Ala Gly Tyr Asp Gly Ser Gln Asn Phe Glu Gln 
                645                 650                 655     

Phe Lys Gln Leu Gln Gly Val Pro Gln Gly Val Thr Glu Ile Ser Gly 
            660                 665                 670         

Val Ala Phe Glu Leu Gln Ser Tyr Thr Gly Pro Gln Gly Lys Glu Gln 
        675                 680                 685             

Glu Asn Leu Thr Asn Asp Ala Val Trp Thr Ala Val Asn Lys Gly Val 
    690                 695                 700                 

Thr Thr Glu Thr Gly Val Lys Phe Asp Thr Glu Val Leu Gln Gly Thr 
705                 710                 715                 720 

Tyr Arg Leu Val Glu Val Arg Lys Glu Ser Thr Tyr Val Gly Pro Asn 
                725                 730                 735     

Gly Lys Val Leu Thr Gly Met Lys Ala Val Pro Ala Leu Ile Ile Leu 
            740                 745                 750         

Pro Leu Val Asn Gln Asn Gly Val Val Glu Asn Ala His Val Tyr Pro 
        755                 760                 765             

Lys Asn Ser Glu Asp Lys Pro Thr Ala Thr Lys Thr Phe Asp Thr Ala 
    770                 775                 780                 

Ala Gly Phe Val Asp Pro Gly Glu Lys Gly Leu Ala Ile Gly Thr Lys 
785                 790                 795                 800 

Val Pro Tyr Ile Val Thr Thr Thr Ile Pro Lys Asn Ser Thr Leu Ala 
                805                 810                 815     

Thr Ala Phe Trp Ser Asp Glu Met Thr Glu Gly Leu Asp Tyr Asn Gly 
            820                 825                 830         

Asp Val Val Val Asn Tyr Asn Gly Gln Pro Leu Asp Asn Ser His Tyr 
        835                 840                 845             

Thr Leu Glu Ala Gly His Asn Gly Phe Ile Leu Lys Leu Asn Glu Lys 
    850                 855                 860                 

Gly Leu Glu Ala Ile Asn Gly Lys Asp Ala Glu Ala Thr Ile Thr Leu 
865                 870                 875                 880 

Lys Tyr Thr Ala Thr Leu Asn Ala Leu Ala Val Ala Asp Val Pro Glu 
                885                 890                 895     

Ala Asn Asp Val Thr Phe His Tyr Gly Asn Asn Pro Gly His Gly Asn 
            900                 905                 910         

Thr Pro Lys Pro Asn Lys Pro Lys Asn Gly Glu Leu Thr Ile Thr Lys 
        915                 920                 925             

Thr Trp Ala Asp Ala Lys Asp Ala Pro Ile Ala Gly Val Glu Val Thr 
    930                 935                 940                 

Phe Asp Leu Val Asn Ala Gln Thr Gly Glu Val Val Lys Val Pro Gly 
945                 950                 955                 960 

His Glu Thr Gly Ile Val Leu Asn Gln Thr Asn Asn Trp Thr Phe Thr 
                965                 970                 975     

Ala Thr Gly Leu Asp Asn Asn Thr Glu Tyr Lys Phe Val Glu Arg Thr 
            980                 985                 990         

Ile Lys Gly Tyr Ser Ala Asp Tyr Gln Thr Ile Thr Glu Thr Gly Lys 
        995                 1000                1005            

Ile Ala Val Lys Asn Trp Lys Asp Glu Asn Pro Glu Pro Ile Asn Pro 
    1010                1015                1020                

Glu Glu Pro Arg Val Lys Thr Tyr Gly Lys Lys Phe Val Lys Val Asp 
1025                1030                1035                1040

Gln Lys Asp Glu Arg Leu Lys Glu Ala Gln Phe Val Val Lys Asn Glu 
                1045                1050                1055    

Gln Gly Lys Tyr Leu Ala Leu Lys Ser Ala Ala Gln Gln Ala Val Asn 
            1060                1065                1070        

Glu Lys Ala Ala Ala Glu Ala Lys Gln Ala Leu Asp Ala Ala Ile Ala 
        1075                1080                1085            

Ala Tyr Thr Asn Ala Ala Asp Lys Asn Ala Ala Gln Ala Val Val Asp 
    1090                1095                1100                

Ala Ala Gln Lys Thr Tyr Asn Asp Asn Tyr Arg Ala Ala Arg Phe Gly 
1105                1110                1115                1120

Tyr Val Glu Val Glu Arg Lys Glu Asp Ala Leu Val Leu Thr Ser Asn 
                1125                1130                1135    

Thr Asp Gly Gln Phe Gln Ile Ser Gly Leu Ala Ala Gly Ser Tyr Thr 
            1140                1145                1150        

Leu Glu Glu Thr Lys Ala Pro Glu Gly Phe Ala Lys Leu Gly Asp Val 
        1155                1160                1165            

Lys Phe Glu Val Gly Ala Gly Ser Trp Asn Gln Gly Asp Phe Asn Tyr 
    1170                1175                1180                

Leu Lys Asp Val Gln Lys Asn Asp Ala Thr Lys Val Val Asn Lys Lys 
1185                1190                1195                1200

Ile Thr Leu Gly Gly Ser Gly Gly Gly Gly Ala Ala Thr Val Phe Ala 
                1205                1210                1215    

Ala Asp Asn Val Ser Thr Ala Pro Asp Ala Val Thr Lys Thr Leu Thr 
            1220                1225                1230        

Ile His Lys Leu Leu Leu Ser Glu Asp Asp Leu Lys Thr Trp Asp Thr 
        1235                1240                1245            

Asn Gly Pro Lys Gly Tyr Asp Gly Thr Gln Ser Ser Leu Lys Asp Leu 
    1250                1255                1260                

Thr Gly Val Val Ala Glu Glu Ile Pro Asn Val Tyr Phe Glu Leu Gln 
1265                1270                1275                1280

Lys Tyr Asn Leu Thr Asp Gly Lys Glu Lys Glu Asn Leu Lys Asp Asp 
                1285                1290                1295    

Ser Lys Trp Thr Thr Val His Gly Gly Leu Thr Thr Lys Asp Gly Leu 
            1300                1305                1310        

Lys Ile Glu Thr Ser Thr Leu Lys Gly Val Tyr Arg Ile Arg Glu Asp 
        1315                1320                1325            

Arg Thr Lys Thr Thr Tyr Val Gly Pro Asn Gly Gln Val Leu Thr Gly 
    1330                1335                1340                

Ser Lys Ala Val Pro Ala Leu Val Thr Leu Pro Leu Val Asn Asn Asn 
1345                1350                1355                1360

Gly Thr Val Ile Asp Ala His Val Phe Pro Lys Asn Ser Tyr Asn Lys 
                1365                1370                1375    

Pro Val Val Asp Lys Arg Ile Ala Asp Thr Leu Asn Tyr Asn Asp Gln 
            1380                1385                1390        

Asn Gly Leu Ser Ile Gly Thr Lys Ile Pro Tyr Val Val Asn Thr Thr 
        1395                1400                1405            

Ile Pro Ser Asn Ala Thr Phe Ala Thr Ser Phe Trp Ser Asp Glu Met 
    1410                1415                1420                

Thr Glu Gly Leu Thr Tyr Asn Glu Asp Val Thr Ile Thr Leu Asn Asn 
1425                1430                1435                1440

Val Ala Met Asp Gln Ala Asp Tyr Glu Val Thr Lys Gly Asn Asn Gly 
                1445                1450                1455    

Phe Asn Leu Lys Leu Thr Glu Ala Gly Leu Ala Lys Ile Asn Gly Lys 
            1460                1465                1470        

Asp Ala Asp Gln Lys Ile Gln Ile Thr Tyr Ser Ala Thr Leu Asn Ser 
        1475                1480                1485            

Leu Ala Val Ala Asp Ile Pro Glu Ser Asn Asp Ile Thr Tyr His Tyr 
    1490                1495                1500                

Gly Asn His Gln Asp His Gly Asn Thr Pro Lys Pro Thr Lys Pro Asn 
1505                1510                1515                1520

Asn Gly Gln Ile Thr Val Thr Lys Thr Trp Asp Ser Gln Pro Ala Pro 
                1525                1530                1535    

Glu Gly Val Lys Ala Thr Val Gln Leu Val Asn Ala Lys Thr Gly Glu 
            1540                1545                1550        

Lys Val Gly Ala Pro Val Glu Leu Ser Glu Asn Asn Trp Thr Tyr Thr 
        1555                1560                1565            

Trp Ser Gly Leu Asp Asn Ser Ile Glu Tyr Lys Val Glu Glu Glu Tyr 
    1570                1575                1580                

Asn Gly Tyr Ser Ala Glu Tyr Thr Val Glu Ser Lys Gly Lys Leu Gly 
1585                1590                1595                1600

Val Lys Asn Trp Lys Asp Asn Asn Pro Ala Pro Ile Asn Pro Glu Glu 
                1605                1610                1615    

Pro Arg Val Lys Thr Tyr Gly Lys Lys Phe Val Lys Val Asp Gln Lys 
            1620                1625                1630        

Asp Thr Arg Leu Glu Asn Ala Gln Phe Val Val Lys Lys Ala Asp Ser 
        1635                1640                1645            

Asn Lys Tyr Ile Ala Phe Lys Ser Thr Ala Gln Gln Ala Ala Asp Glu 
    1650                1655                1660                

Lys Ala Ala Ala Thr Ala Lys Gln Lys Leu Asp Ala Ala Val Ala Ala 
1665                1670                1675                1680

Tyr Thr Asn Ala Ala Asp Lys Gln Ala Ala Gln Ala Leu Val Asp Gln 
                1685                1690                1695    

Ala Gln Gln Glu Tyr Asn Val Ala Tyr Lys Glu Ala Lys Phe Gly Tyr 
            1700                1705                1710        

Val Glu Val Ala Gly Lys Asp Glu Ala Met Val Leu Thr Ser Asn Thr 
        1715                1720                1725            

Asp Gly Gln Phe Gln Ile Ser Gly Leu Ala Ala Gly Thr Tyr Lys Leu 
    1730                1735                1740                

Glu Glu Ile Lys Ala Pro Glu Gly Phe Ala Lys Ile Asp Asp Val Glu 
1745                1750                1755                1760

Phe Val Val Gly Ala Gly Ser Trp Asn Gln Gly Glu Phe Asn Tyr Leu 
                1765                1770                1775    

Lys Asp Val Gln Lys Asn Asp Ala Thr Lys Val Val Asn Lys Lys Ile 
            1780                1785                1790        

Thr Leu Gly His His His His His His 
        1795                1800    

<210>   249
<211>   5403
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Sequence encoding SEQ ID NO: 248

<400>   249
atggctagcg ctgcaacagt ttttgcggct gggacgacaa caacatctgt taccgttcat   60
aaactattgg caacagatgg ggatatggat aaaattgcaa atgagttaga aacaggtaac   120
tatgctggta ataaagtggg tgttctacct gcaaatgcaa aagaaattgc cggtgttatg   180
ttcgtttgga caaatactaa taatgaaatt attgatgaaa atggccaaac tctaggagtg   240
aatattgatc cacaaacatt taaactctca ggggcaatgc cggcaactgc aatgaaaaaa   300
ttaacagaag ctgaaggagc taaatttaac acggcaaatt taccagctgc taagtataaa   360
atttatgaaa ttcacagttt atcaacttat gtcggtgaag atggagcaac cttaacaggt   420
tctaaagcag ttccaattga aattgaatta ccattgaacg atgttgtgga tgcgcatgtg   480
tatccaaaaa atacagaagc aaagccaaaa attgataaag atttcaaagg taaagcaaat   540
ccagatacac cacgtgtaga taaagataca cctgtgaacc accaagttgg agatgttgta   600
gagtacgaaa ttgttacaaa aattccagca cttgctaatt atgcaacagc aaactggagc   660
gatagaatga ctgaaggttt ggcattcaac aaaggtacag tgaaagtaac tgttgatgat   720
gttgcacttg aagcaggtga ttatgctcta acagaagtag caactggttt tgatttgaaa   780
ttaacagatg ctggtttagc taaagtgaat gaccaaaacg ctgaaaaaac tgtgaaaatc   840
acttattcgg caacattgaa tgacaaagca attgtagaag taccagaatc taatgatgta   900
acatttaact atggtaataa tccagatcac gggaatactc caaagccgaa taagccaaat   960
gaaaacggcg atttgacatt gaccaagaca tgggttgatg ctacaggtgc accaattccg   1020
gctggagctg aagcaacgtt cgatttggtt aatgctcaga ctggtaaagt tgtacaaact   1080
gtaactttga caacagacaa aaatacagtt actgttaacg gattggataa aaatacagaa   1140
tataaattcg ttgaacgtag tataaaaggg tattcagcag attatcaaga aatcactaca   1200
gctggagaaa ttgctgtcaa gaactggaaa gacgaaaatc caaaaccact tgatccaaca   1260
gagccaaaag ttgttacata tggtaaaaag tttgtcaaag ttaatgataa agataatcgt   1320
ttagctgggg cagaatttgt aattgcaaat gctgataatg ctggtcaata tttagcacgt   1380
aaagcagata aagtgagtca agaagagaag cagttggttg ttacaacaaa ggatgcttta   1440
gatagagcag ttgctgctta taacgctctt actgcacaac aacaaactca gcaagaaaaa   1500
gagaaagttg acaaagctca agctgcttat aatgctgctg tgattgctgc caacaatgca   1560
tttgaatggg tggcagataa ggacaatgaa aatgttgtga aattagtttc tgatgcacaa   1620
ggtcgctttg aaattacagg ccttcttgca ggtacatatt acttagaaga aacaaaacag   1680
cctgctggtt atgcattact aactagccgt cagaaatttg aagtcactgc aacttcttat   1740
tcagcgactg gacaaggcat tgagtatact gctggttcag gtaaagatga cgctacaaaa   1800
gtagtcaaca aaaaaatcac tggatccggc agcggtggcg gtggcgcgga acaaaaaact   1860
aagacactta cagttcataa attattgatg acagatcaag agcttgacgc ttggaattct   1920
gatgcgatta ctactgcagg ttatgacggt tcgcaaaatt ttgaacagtt caaacaactt   1980
caaggtgttc cacaaggagt aaccgaaatc tctggtgttg cattcgagtt acagagttat   2040
acgggtcctc aaggaaaaga acaagaaaat ttaacgaatg atgcggtttg gactgcggtt   2100
aataaaggtg tgacgactga aacgggtgtt aaatttgata ctgaagtttt acaagggaca   2160
tatcgtcttg tcgaagtacg taaagaatcg acttatgtcg gtccaaatgg taaagtttta   2220
acaggtatga aagctgttcc tgctttaatt attctgccgc ttgtaaacca aaatggtgtt   2280
gtagaaaatg cacatgtcta tccaaagaat tctgaagaca aacctacagc aacgaaaaca   2340
tttgatactg cagcaggttt cgtagatcca ggtgaaaaag gtttagcaat tggcactaag   2400
gtaccgtata ttgttacaac aactattccg aaaaactcaa ctcttgcaac agctttctgg   2460
tcagatgaaa tgacagaagg tctagattat aatggtgatg tagttgttaa ttataatggt   2520
caaccgcttg ataattctca ttacacatta gaagcaggtc ataatggctt tatcttgaag   2580
ttaaatgaaa aaggtctgga agcaatcaac ggtaaagatg cagaagcaac aattacgttg   2640
aagtatactg caactttaaa tgctcttgct gttgctgatg tgccagaagc gaatgatgta   2700
acattccatt atggaaacaa cccaggtcat ggtaacactc caaaaccaaa caaacctaaa   2760
aacggtgaac ttacaattac taaaacatgg gctgatgcta aagatgctcc tatagcaggt   2820
gtagaagtaa cttttgattt ggtaaatgct cagacaggtg aggtcgttaa agtacctgga   2880
catgaaacag gtattgtatt gaatcaaaca aataattgga catttactgc tacaggtctt   2940
gataataata cagaatataa atttgttgaa cggacaatta agggatattc tgcagattac   3000
caaacaatta ctgaaacagg aaaaattgct gttaaaaact ggaaagatga aaatccagaa   3060
ccaataaatc ctgaagagcc acgtgtaaaa acatatggta aaaaattcgt taaggttgac   3120
caaaaagacg aacgcttaaa agaagcacaa ttcgttgtga agaatgagca agggaaatat   3180
cttgcactca aatctgcagc acaacaagct gtaaatgaga aagctgccgc agaagcgaaa   3240
caagcgctag atgcagcgat agcagcctat acaaatgctg cagataaaaa tgcagcacaa   3300
gctgtagtag atgctgcgca aaaaacatat aatgacaatt acagagcagc tagatttggc   3360
tatgtagaag tagagagaaa agaagatgcg ttagttctta cttctaacac tgatggtcaa   3420
ttccaaattt caggtcttgc tgctggaagc tacacgttgg aagaaacaaa agctccagaa   3480
ggctttgcaa aacttggaga tgtgaagttt gaggttggag caggttcttg gaatcaaggt   3540
gatttcaatt atttaaaaga tgttcagaag aacgacgcta caaaagtagt caacaaaaaa   3600
atcacgctcg agggcagcgg tggcggtggc gctgcaacag tttttgcggc ggacaatgtt   3660
agtacagcac cagatgctgt tactaaaact ttaacaatcc ataagttact gctctcagaa   3720
gatgatttaa agacttggga tacaaacggt cctaaaggat atgatggaac tcaatctagt   3780
ttaaaagatt taactggagt tgtagctgag gaaattccaa atgtatactt tgaattacaa   3840
aagtataatt tgactgatgg taaggaaaaa gaaaatctta aagatgatag taaatggaca   3900
acagttcatg gtggtttgac aactaaagat ggacttaaaa ttgaaaccag tactcttaaa   3960
ggtgtgtatc gtattcgtga ggatagaaca aagactacct atgttggtcc taatgggcaa   4020
gtattaacag gttcaaaagc cgtacctgct cttgtaactc ttccacttgt taacaataat   4080
ggtacagtaa ttgatgcaca tgttttccct aaaaattcat ataataaacc agttgtagat   4140
aaaagaattg ctgatacttt gaattataac gatcaaaatg gtctgtctat cggtactaaa   4200
atcccatatg ttgttaatac aacaattcca agtaatgcaa catttgcaac ttcattttgg   4260
tcagatgaaa tgacagaagg tctaacttat aatgaagatg taacaattac tttgaataat   4320
gtagctatgg atcaagctga ttatgaagtc actaaaggaa ataatggctt taacttaaaa   4380
ttaacagaag caggtttagc taaaattaat ggtaaggatg cagaccaaaa aatccaaatt   4440
acttactcag ctactttgaa ctcacttgct gttgcagaca ttcctgaaag taacgatatt   4500
acatatcatt acggaaatca tcaagatcat gggaatactc caaaaccaac taaacctaat   4560
aatggtcaaa ttacagtaac taagacatgg gacagtcaac ctgctcctga gggggtgaaa   4620
gcgactgttc aacttgtaaa tgccaagact ggtgagaaag tcggtgctcc tgtagaactt   4680
tcagaaaata attggacata tacttggagt ggtctagata attctattga atacaaagtt   4740
gaagaagaat ataatggata ctcagctgaa tacacagtag agagcaaagg gaagttgggg   4800
gtaaaaaact ggaaagataa taacccagct ccaatcaatc ctgaagaacc acgtgtaaaa   4860
acatacggta aaaagtttgt caaagtagac caaaaagata ctcgtctaga aaatgcgcag   4920
ttcgttgtta aaaaagcaga tagcaataaa tatattgcct ttaagtcaac tgcacaacaa   4980
gctgcagatg aaaaagcagc agcaactgca aaacaaaaat tggatgcagc ggtagcagct   5040
tacacaaatg ctgcagataa gcaagccgct caagctctag tagatcaagc acagcaagaa   5100
tacaatgtag cttacaaaga agccaaattt ggttatgttg aagtagctgg aaaagatgaa   5160
gcaatggttc ttacttctaa tacggatggt caattccaaa tttcaggtct tgctgctggt   5220
acttataaat tagaagaaat taaagctcca gaaggttttg cgaaaattga tgatgtagaa   5280
tttgttgttg gagcaggttc ttggaatcaa ggtgagttta attacttaaa agatgttcaa   5340
aagaatgacg ctacaaaagt agtcaacaaa aaaatcactc tcgagcacca ccaccaccac   5400
cac                                                                 5403

<210>   250
<211>   1801
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   RrgB III-II-I

<400>   250
Met Ala Ser Ala Glu Gln Lys Thr Lys Thr Leu Thr Val His Lys Leu 
1               5                   10                  15      

Leu Met Thr Asp Gln Glu Leu Asp Ala Trp Asn Ser Asp Ala Ile Thr 
            20                  25                  30          

Thr Ala Gly Tyr Asp Gly Ser Gln Asn Phe Glu Gln Phe Lys Gln Leu 
        35                  40                  45              

Gln Gly Val Pro Gln Gly Val Thr Glu Ile Ser Gly Val Ala Phe Glu 
    50                  55                  60                  

Leu Gln Ser Tyr Thr Gly Pro Gln Gly Lys Glu Gln Glu Asn Leu Thr 
65                  70                  75                  80  

Asn Asp Ala Val Trp Thr Ala Val Asn Lys Gly Val Thr Thr Glu Thr 
                85                  90                  95      

Gly Val Lys Phe Asp Thr Glu Val Leu Gln Gly Thr Tyr Arg Leu Val 
            100                 105                 110         

Glu Val Arg Lys Glu Ser Thr Tyr Val Gly Pro Asn Gly Lys Val Leu 
        115                 120                 125             

Thr Gly Met Lys Ala Val Pro Ala Leu Ile Ile Leu Pro Leu Val Asn 
    130                 135                 140                 

Gln Asn Gly Val Val Glu Asn Ala His Val Tyr Pro Lys Asn Ser Glu 
145                 150                 155                 160 

Asp Lys Pro Thr Ala Thr Lys Thr Phe Asp Thr Ala Ala Gly Phe Val 
                165                 170                 175     

Asp Pro Gly Glu Lys Gly Leu Ala Ile Gly Thr Lys Val Pro Tyr Ile 
            180                 185                 190         

Val Thr Thr Thr Ile Pro Lys Asn Ser Thr Leu Ala Thr Ala Phe Trp 
        195                 200                 205             

Ser Asp Glu Met Thr Glu Gly Leu Asp Tyr Asn Gly Asp Val Val Val 
    210                 215                 220                 

Asn Tyr Asn Gly Gln Pro Leu Asp Asn Ser His Tyr Thr Leu Glu Ala 
225                 230                 235                 240 

Gly His Asn Gly Phe Ile Leu Lys Leu Asn Glu Lys Gly Leu Glu Ala 
                245                 250                 255     

Ile Asn Gly Lys Asp Ala Glu Ala Thr Ile Thr Leu Lys Tyr Thr Ala 
            260                 265                 270         

Thr Leu Asn Ala Leu Ala Val Ala Asp Val Pro Glu Ala Asn Asp Val 
        275                 280                 285             

Thr Phe His Tyr Gly Asn Asn Pro Gly His Gly Asn Thr Pro Lys Pro 
    290                 295                 300                 

Asn Lys Pro Lys Asn Gly Glu Leu Thr Ile Thr Lys Thr Trp Ala Asp 
305                 310                 315                 320 

Ala Lys Asp Ala Pro Ile Ala Gly Val Glu Val Thr Phe Asp Leu Val 
                325                 330                 335     

Asn Ala Gln Thr Gly Glu Val Val Lys Val Pro Gly His Glu Thr Gly 
            340                 345                 350         

Ile Val Leu Asn Gln Thr Asn Asn Trp Thr Phe Thr Ala Thr Gly Leu 
        355                 360                 365             

Asp Asn Asn Thr Glu Tyr Lys Phe Val Glu Arg Thr Ile Lys Gly Tyr 
    370                 375                 380                 

Ser Ala Asp Tyr Gln Thr Ile Thr Glu Thr Gly Lys Ile Ala Val Lys 
385                 390                 395                 400 

Asn Trp Lys Asp Glu Asn Pro Glu Pro Ile Asn Pro Glu Glu Pro Arg 
                405                 410                 415     

Val Lys Thr Tyr Gly Lys Lys Phe Val Lys Val Asp Gln Lys Asp Glu 
            420                 425                 430         

Arg Leu Lys Glu Ala Gln Phe Val Val Lys Asn Glu Gln Gly Lys Tyr 
        435                 440                 445             

Leu Ala Leu Lys Ser Ala Ala Gln Gln Ala Val Asn Glu Lys Ala Ala 
    450                 455                 460                 

Ala Glu Ala Lys Gln Ala Leu Asp Ala Ala Ile Ala Ala Tyr Thr Asn 
465                 470                 475                 480 

Ala Ala Asp Lys Asn Ala Ala Gln Ala Val Val Asp Ala Ala Gln Lys 
                485                 490                 495     

Thr Tyr Asn Asp Asn Tyr Arg Ala Ala Arg Phe Gly Tyr Val Glu Val 
            500                 505                 510         

Glu Arg Lys Glu Asp Ala Leu Val Leu Thr Ser Asn Thr Asp Gly Gln 
        515                 520                 525             

Phe Gln Ile Ser Gly Leu Ala Ala Gly Ser Tyr Thr Leu Glu Glu Thr 
    530                 535                 540                 

Lys Ala Pro Glu Gly Phe Ala Lys Leu Gly Asp Val Lys Phe Glu Val 
545                 550                 555                 560 

Gly Ala Gly Ser Trp Asn Gln Gly Asp Phe Asn Tyr Leu Lys Asp Val 
                565                 570                 575     

Gln Lys Asn Asp Ala Thr Lys Val Val Asn Lys Lys Ile Thr Gly Ser 
            580                 585                 590         

Gly Ser Gly Gly Gly Gly Ala Ala Thr Val Phe Ala Ala Asp Asn Val 
        595                 600                 605             

Ser Thr Ala Pro Asp Ala Val Thr Lys Thr Leu Thr Ile His Lys Leu 
    610                 615                 620                 

Leu Leu Ser Glu Asp Asp Leu Lys Thr Trp Asp Thr Asn Gly Pro Lys 
625                 630                 635                 640 

Gly Tyr Asp Gly Thr Gln Ser Ser Leu Lys Asp Leu Thr Gly Val Val 
                645                 650                 655     

Ala Glu Glu Ile Pro Asn Val Tyr Phe Glu Leu Gln Lys Tyr Asn Leu 
            660                 665                 670         

Thr Asp Gly Lys Glu Lys Glu Asn Leu Lys Asp Asp Ser Lys Trp Thr 
        675                 680                 685             

Thr Val His Gly Gly Leu Thr Thr Lys Asp Gly Leu Lys Ile Glu Thr 
    690                 695                 700                 

Ser Thr Leu Lys Gly Val Tyr Arg Ile Arg Glu Asp Arg Thr Lys Thr 
705                 710                 715                 720 

Thr Tyr Val Gly Pro Asn Gly Gln Val Leu Thr Gly Ser Lys Ala Val 
                725                 730                 735     

Pro Ala Leu Val Thr Leu Pro Leu Val Asn Asn Asn Gly Thr Val Ile 
            740                 745                 750         

Asp Ala His Val Phe Pro Lys Asn Ser Tyr Asn Lys Pro Val Val Asp 
        755                 760                 765             

Lys Arg Ile Ala Asp Thr Leu Asn Tyr Asn Asp Gln Asn Gly Leu Ser 
    770                 775                 780                 

Ile Gly Thr Lys Ile Pro Tyr Val Val Asn Thr Thr Ile Pro Ser Asn 
785                 790                 795                 800 

Ala Thr Phe Ala Thr Ser Phe Trp Ser Asp Glu Met Thr Glu Gly Leu 
                805                 810                 815     

Thr Tyr Asn Glu Asp Val Thr Ile Thr Leu Asn Asn Val Ala Met Asp 
            820                 825                 830         

Gln Ala Asp Tyr Glu Val Thr Lys Gly Asn Asn Gly Phe Asn Leu Lys 
        835                 840                 845             

Leu Thr Glu Ala Gly Leu Ala Lys Ile Asn Gly Lys Asp Ala Asp Gln 
    850                 855                 860                 

Lys Ile Gln Ile Thr Tyr Ser Ala Thr Leu Asn Ser Leu Ala Val Ala 
865                 870                 875                 880 

Asp Ile Pro Glu Ser Asn Asp Ile Thr Tyr His Tyr Gly Asn His Gln 
                885                 890                 895     

Asp His Gly Asn Thr Pro Lys Pro Thr Lys Pro Asn Asn Gly Gln Ile 
            900                 905                 910         

Thr Val Thr Lys Thr Trp Asp Ser Gln Pro Ala Pro Glu Gly Val Lys 
        915                 920                 925             

Ala Thr Val Gln Leu Val Asn Ala Lys Thr Gly Glu Lys Val Gly Ala 
    930                 935                 940                 

Pro Val Glu Leu Ser Glu Asn Asn Trp Thr Tyr Thr Trp Ser Gly Leu 
945                 950                 955                 960 

Asp Asn Ser Ile Glu Tyr Lys Val Glu Glu Glu Tyr Asn Gly Tyr Ser 
                965                 970                 975     

Ala Glu Tyr Thr Val Glu Ser Lys Gly Lys Leu Gly Val Lys Asn Trp 
            980                 985                 990         

Lys Asp Asn Asn Pro Ala Pro Ile Asn Pro Glu Glu Pro Arg Val Lys 
        995                 1000                1005            

Thr Tyr Gly Lys Lys Phe Val Lys Val Asp Gln Lys Asp Thr Arg Leu 
    1010                1015                1020                

Glu Asn Ala Gln Phe Val Val Lys Lys Ala Asp Ser Asn Lys Tyr Ile 
1025                1030                1035                1040

Ala Phe Lys Ser Thr Ala Gln Gln Ala Ala Asp Glu Lys Ala Ala Ala 
                1045                1050                1055    

Thr Ala Lys Gln Lys Leu Asp Ala Ala Val Ala Ala Tyr Thr Asn Ala 
            1060                1065                1070        

Ala Asp Lys Gln Ala Ala Gln Ala Leu Val Asp Gln Ala Gln Gln Glu 
        1075                1080                1085            

Tyr Asn Val Ala Tyr Lys Glu Ala Lys Phe Gly Tyr Val Glu Val Ala 
    1090                1095                1100                

Gly Lys Asp Glu Ala Met Val Leu Thr Ser Asn Thr Asp Gly Gln Phe 
1105                1110                1115                1120

Gln Ile Ser Gly Leu Ala Ala Gly Thr Tyr Lys Leu Glu Glu Ile Lys 
                1125                1130                1135    

Ala Pro Glu Gly Phe Ala Lys Ile Asp Asp Val Glu Phe Val Val Gly 
            1140                1145                1150        

Ala Gly Ser Trp Asn Gln Gly Glu Phe Asn Tyr Leu Lys Asp Val Gln 
        1155                1160                1165            

Lys Asn Asp Ala Thr Lys Val Val Asn Lys Lys Ile Thr Leu Gly Gly 
    1170                1175                1180                

Ser Gly Gly Gly Gly Ala Ala Thr Val Phe Ala Ala Gly Thr Thr Thr 
1185                1190                1195                1200

Thr Ser Val Thr Val His Lys Leu Leu Ala Thr Asp Gly Asp Met Asp 
                1205                1210                1215    

Lys Ile Ala Asn Glu Leu Glu Thr Gly Asn Tyr Ala Gly Asn Lys Val 
            1220                1225                1230        

Gly Val Leu Pro Ala Asn Ala Lys Glu Ile Ala Gly Val Met Phe Val 
        1235                1240                1245            

Trp Thr Asn Thr Asn Asn Glu Ile Ile Asp Glu Asn Gly Gln Thr Leu 
    1250                1255                1260                

Gly Val Asn Ile Asp Pro Gln Thr Phe Lys Leu Ser Gly Ala Met Pro 
1265                1270                1275                1280

Ala Thr Ala Met Lys Lys Leu Thr Glu Ala Glu Gly Ala Lys Phe Asn 
                1285                1290                1295    

Thr Ala Asn Leu Pro Ala Ala Lys Tyr Lys Ile Tyr Glu Ile His Ser 
            1300                1305                1310        

Leu Ser Thr Tyr Val Gly Glu Asp Gly Ala Thr Leu Thr Gly Ser Lys 
        1315                1320                1325            

Ala Val Pro Ile Glu Ile Glu Leu Pro Leu Asn Asp Val Val Asp Ala 
    1330                1335                1340                

His Val Tyr Pro Lys Asn Thr Glu Ala Lys Pro Lys Ile Asp Lys Asp 
1345                1350                1355                1360

Phe Lys Gly Lys Ala Asn Pro Asp Thr Pro Arg Val Asp Lys Asp Thr 
                1365                1370                1375    

Pro Val Asn His Gln Val Gly Asp Val Val Glu Tyr Glu Ile Val Thr 
            1380                1385                1390        

Lys Ile Pro Ala Leu Ala Asn Tyr Ala Thr Ala Asn Trp Ser Asp Arg 
        1395                1400                1405            

Met Thr Glu Gly Leu Ala Phe Asn Lys Gly Thr Val Lys Val Thr Val 
    1410                1415                1420                

Asp Asp Val Ala Leu Glu Ala Gly Asp Tyr Ala Leu Thr Glu Val Ala 
1425                1430                1435                1440

Thr Gly Phe Asp Leu Lys Leu Thr Asp Ala Gly Leu Ala Lys Val Asn 
                1445                1450                1455    

Asp Gln Asn Ala Glu Lys Thr Val Lys Ile Thr Tyr Ser Ala Thr Leu 
            1460                1465                1470        

Asn Asp Lys Ala Ile Val Glu Val Pro Glu Ser Asn Asp Val Thr Phe 
        1475                1480                1485            

Asn Tyr Gly Asn Asn Pro Asp His Gly Asn Thr Pro Lys Pro Asn Lys 
    1490                1495                1500                

Pro Asn Glu Asn Gly Asp Leu Thr Leu Thr Lys Thr Trp Val Asp Ala 
1505                1510                1515                1520

Thr Gly Ala Pro Ile Pro Ala Gly Ala Glu Ala Thr Phe Asp Leu Val 
                1525                1530                1535    

Asn Ala Gln Thr Gly Lys Val Val Gln Thr Val Thr Leu Thr Thr Asp 
            1540                1545                1550        

Lys Asn Thr Val Thr Val Asn Gly Leu Asp Lys Asn Thr Glu Tyr Lys 
        1555                1560                1565            

Phe Val Glu Arg Ser Ile Lys Gly Tyr Ser Ala Asp Tyr Gln Glu Ile 
    1570                1575                1580                

Thr Thr Ala Gly Glu Ile Ala Val Lys Asn Trp Lys Asp Glu Asn Pro 
1585                1590                1595                1600

Lys Pro Leu Asp Pro Thr Glu Pro Lys Val Val Thr Tyr Gly Lys Lys 
                1605                1610                1615    

Phe Val Lys Val Asn Asp Lys Asp Asn Arg Leu Ala Gly Ala Glu Phe 
            1620                1625                1630        

Val Ile Ala Asn Ala Asp Asn Ala Gly Gln Tyr Leu Ala Arg Lys Ala 
        1635                1640                1645            

Asp Lys Val Ser Gln Glu Glu Lys Gln Leu Val Val Thr Thr Lys Asp 
    1650                1655                1660                

Ala Leu Asp Arg Ala Val Ala Ala Tyr Asn Ala Leu Thr Ala Gln Gln 
1665                1670                1675                1680

Gln Thr Gln Gln Glu Lys Glu Lys Val Asp Lys Ala Gln Ala Ala Tyr 
                1685                1690                1695    

Asn Ala Ala Val Ile Ala Ala Asn Asn Ala Phe Glu Trp Val Ala Asp 
            1700                1705                1710        

Lys Asp Asn Glu Asn Val Val Lys Leu Val Ser Asp Ala Gln Gly Arg 
        1715                1720                1725            

Phe Glu Ile Thr Gly Leu Leu Ala Gly Thr Tyr Tyr Leu Glu Glu Thr 
    1730                1735                1740                

Lys Gln Pro Ala Gly Tyr Ala Leu Leu Thr Ser Arg Gln Lys Phe Glu 
1745                1750                1755                1760

Val Thr Ala Thr Ser Tyr Ser Ala Thr Gly Gln Gly Ile Glu Tyr Thr 
                1765                1770                1775    

Ala Gly Ser Gly Lys Asp Asp Ala Thr Lys Val Val Asn Lys Lys Ile 
            1780                1785                1790        

Thr Leu Gly His His His His His His 
        1795                1800    

<210>   251
<211>   5403
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Sequence encoding SEQ ID NO: 250

<400>   251
atggctagcg cggaacaaaa aactaagaca cttacagttc ataaattatt gatgacagat   60
caagagcttg acgcttggaa ttctgatgcg attactactg caggttatga cggttcgcaa   120
aattttgaac agttcaaaca acttcaaggt gttccacaag gagtaaccga aatctctggt   180
gttgcattcg agttacagag ttatacgggt cctcaaggaa aagaacaaga aaatttaacg   240
aatgatgcgg tttggactgc ggttaataaa ggtgtgacga ctgaaacggg tgttaaattt   300
gatactgaag ttttacaagg gacatatcgt cttgtcgaag tacgtaaaga atcgacttat   360
gtcggtccaa atggtaaagt tttaacaggt atgaaagctg ttcctgcttt aattattctg   420
ccgcttgtaa accaaaatgg tgttgtagaa aatgcacatg tctatccaaa gaattctgaa   480
gacaaaccta cagcaacgaa aacatttgat actgcagcag gtttcgtaga tccaggtgaa   540
aaaggtttag caattggcac taaggtaccg tatattgtta caacaactat tccgaaaaac   600
tcaactcttg caacagcttt ctggtcagat gaaatgacag aaggtctaga ttataatggt   660
gatgtagttg ttaattataa tggtcaaccg cttgataatt ctcattacac attagaagca   720
ggtcataatg gctttatctt gaagttaaat gaaaaaggtc tggaagcaat caacggtaaa   780
gatgcagaag caacaattac gttgaagtat actgcaactt taaatgctct tgctgttgct   840
gatgtgccag aagcgaatga tgtaacattc cattatggaa acaacccagg tcatggtaac   900
actccaaaac caaacaaacc taaaaacggt gaacttacaa ttactaaaac atgggctgat   960
gctaaagatg ctcctatagc aggtgtagaa gtaacttttg atttggtaaa tgctcagaca   1020
ggtgaggtcg ttaaagtacc tggacatgaa acaggtattg tattgaatca aacaaataat   1080
tggacattta ctgctacagg tcttgataat aatacagaat ataaatttgt tgaacggaca   1140
attaagggat attctgcaga ttaccaaaca attactgaaa caggaaaaat tgctgttaaa   1200
aactggaaag atgaaaatcc agaaccaata aatcctgaag agccacgtgt aaaaacatat   1260
ggtaaaaaat tcgttaaggt tgaccaaaaa gacgaacgct taaaagaagc acaattcgtt   1320
gtgaagaatg agcaagggaa atatcttgca ctcaaatctg cagcacaaca agctgtaaat   1380
gagaaagctg ccgcagaagc gaaacaagcg ctagatgcag cgatagcagc ctatacaaat   1440
gctgcagata aaaatgcagc acaagctgta gtagatgctg cgcaaaaaac atataatgac   1500
aattacagag cagctagatt tggctatgta gaagtagaga gaaaagaaga tgcgttagtt   1560
cttacttcta acactgatgg tcaattccaa atttcaggtc ttgctgctgg aagctacacg   1620
ttggaagaaa caaaagctcc agaaggcttt gcaaaacttg gagatgtgaa gtttgaggtt   1680
ggagcaggtt cttggaatca aggtgatttc aattatttaa aagatgttca gaagaacgac   1740
gctacaaaag tagtcaacaa aaaaatcacg ggatccggca gcggtggcgg tggcgctgca   1800
acagtttttg cggcggacaa tgttagtaca gcaccagatg ctgttactaa aactttaaca   1860
atccataagt tactgctctc agaagatgat ttaaagactt gggatacaaa cggtcctaaa   1920
ggatatgatg gaactcaatc tagtttaaaa gatttaactg gagttgtagc tgaggaaatt   1980
ccaaatgtat actttgaatt acaaaagtat aatttgactg atggtaagga aaaagaaaat   2040
cttaaagatg atagtaaatg gacaacagtt catggtggtt tgacaactaa agatggactt   2100
aaaattgaaa ccagtactct taaaggtgtg tatcgtattc gtgaggatag aacaaagact   2160
acctatgttg gtcctaatgg gcaagtatta acaggttcaa aagccgtacc tgctcttgta   2220
actcttccac ttgttaacaa taatggtaca gtaattgatg cacatgtttt ccctaaaaat   2280
tcatataata aaccagttgt agataaaaga attgctgata ctttgaatta taacgatcaa   2340
aatggtctgt ctatcggtac taaaatccca tatgttgtta atacaacaat tccaagtaat   2400
gcaacatttg caacttcatt ttggtcagat gaaatgacag aaggtctaac ttataatgaa   2460
gatgtaacaa ttactttgaa taatgtagct atggatcaag ctgattatga agtcactaaa   2520
ggaaataatg gctttaactt aaaattaaca gaagcaggtt tagctaaaat taatggtaag   2580
gatgcagacc aaaaaatcca aattacttac tcagctactt tgaactcact tgctgttgca   2640
gacattcctg aaagtaacga tattacatat cattacggaa atcatcaaga tcatgggaat   2700
actccaaaac caactaaacc taataatggt caaattacag taactaagac atgggacagt   2760
caacctgctc ctgagggggt gaaagcgact gttcaacttg taaatgccaa gactggtgag   2820
aaagtcggtg ctcctgtaga actttcagaa aataattgga catatacttg gagtggtcta   2880
gataattcta ttgaatacaa agttgaagaa gaatataatg gatactcagc tgaatacaca   2940
gtagagagca aagggaagtt gggggtaaaa aactggaaag ataataaccc agctccaatc   3000
aatcctgaag aaccacgtgt aaaaacatac ggtaaaaagt ttgtcaaagt agaccaaaaa   3060
gatactcgtc tagaaaatgc gcagttcgtt gttaaaaaag cagatagcaa taaatatatt   3120
gcctttaagt caactgcaca acaagctgca gatgaaaaag cagcagcaac tgcaaaacaa   3180
aaattggatg cagcggtagc agcttacaca aatgctgcag ataagcaagc cgctcaagct   3240
ctagtagatc aagcacagca agaatacaat gtagcttaca aagaagccaa atttggttat   3300
gttgaagtag ctggaaaaga tgaagcaatg gttcttactt ctaatacgga tggtcaattc   3360
caaatttcag gtcttgctgc tggtacttat aaattagaag aaattaaagc tccagaaggt   3420
tttgcgaaaa ttgatgatgt agaatttgtt gttggagcag gttcttggaa tcaaggtgag   3480
tttaattact taaaagatgt tcaaaagaat gacgctacaa aagtagtcaa caaaaaaatc   3540
actctcgagg gcagcggtgg cggtggcgct gcaacagttt ttgcggctgg gacgacaaca   3600
acatctgtta ccgttcataa actattggca acagatgggg atatggataa aattgcaaat   3660
gagttagaaa caggtaacta tgctggtaat aaagtgggtg ttctacctgc aaatgcaaaa   3720
gaaattgccg gtgttatgtt cgtttggaca aatactaata atgaaattat tgatgaaaat   3780
ggccaaactc taggagtgaa tattgatcca caaacattta aactctcagg ggcaatgccg   3840
gcaactgcaa tgaaaaaatt aacagaagct gaaggagcta aatttaacac ggcaaattta   3900
ccagctgcta agtataaaat ttatgaaatt cacagtttat caacttatgt cggtgaagat   3960
ggagcaacct taacaggttc taaagcagtt ccaattgaaa ttgaattacc attgaacgat   4020
gttgtggatg cgcatgtgta tccaaaaaat acagaagcaa agccaaaaat tgataaagat   4080
ttcaaaggta aagcaaatcc agatacacca cgtgtagata aagatacacc tgtgaaccac   4140
caagttggag atgttgtaga gtacgaaatt gttacaaaaa ttccagcact tgctaattat   4200
gcaacagcaa actggagcga tagaatgact gaaggtttgg cattcaacaa aggtacagtg   4260
aaagtaactg ttgatgatgt tgcacttgaa gcaggtgatt atgctctaac agaagtagca   4320
actggttttg atttgaaatt aacagatgct ggtttagcta aagtgaatga ccaaaacgct   4380
gaaaaaactg tgaaaatcac ttattcggca acattgaatg acaaagcaat tgtagaagta   4440
ccagaatcta atgatgtaac atttaactat ggtaataatc cagatcacgg gaatactcca   4500
aagccgaata agccaaatga aaacggcgat ttgacattga ccaagacatg ggttgatgct   4560
acaggtgcac caattccggc tggagctgaa gcaacgttcg atttggttaa tgctcagact   4620
ggtaaagttg tacaaactgt aactttgaca acagacaaaa atacagttac tgttaacgga   4680
ttggataaaa atacagaata taaattcgtt gaacgtagta taaaagggta ttcagcagat   4740
tatcaagaaa tcactacagc tggagaaatt gctgtcaaga actggaaaga cgaaaatcca   4800
aaaccacttg atccaacaga gccaaaagtt gttacatatg gtaaaaagtt tgtcaaagtt   4860
aatgataaag ataatcgttt agctggggca gaatttgtaa ttgcaaatgc tgataatgct   4920
ggtcaatatt tagcacgtaa agcagataaa gtgagtcaag aagagaagca gttggttgtt   4980
acaacaaagg atgctttaga tagagcagtt gctgcttata acgctcttac tgcacaacaa   5040
caaactcagc aagaaaaaga gaaagttgac aaagctcaag ctgcttataa tgctgctgtg   5100
attgctgcca acaatgcatt tgaatgggtg gcagataagg acaatgaaaa tgttgtgaaa   5160
ttagtttctg atgcacaagg tcgctttgaa attacaggcc ttcttgcagg tacatattac   5220
ttagaagaaa caaaacagcc tgctggttat gcattactaa ctagccgtca gaaatttgaa   5280
gtcactgcaa cttcttattc agcgactgga caaggcattg agtatactgc tggttcaggt   5340
aaagatgacg ctacaaaagt agtcaacaaa aaaatcactc tcgagcacca ccaccaccac   5400
cac                                                                 5403

<210>   252
<211>   1801
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   RrgB III-I-II

<400>   252
Met Ala Ser Ala Glu Gln Lys Thr Lys Thr Leu Thr Val His Lys Leu 
1               5                   10                  15      

Leu Met Thr Asp Gln Glu Leu Asp Ala Trp Asn Ser Asp Ala Ile Thr 
            20                  25                  30          

Thr Ala Gly Tyr Asp Gly Ser Gln Asn Phe Glu Gln Phe Lys Gln Leu 
        35                  40                  45              

Gln Gly Val Pro Gln Gly Val Thr Glu Ile Ser Gly Val Ala Phe Glu 
    50                  55                  60                  

Leu Gln Ser Tyr Thr Gly Pro Gln Gly Lys Glu Gln Glu Asn Leu Thr 
65                  70                  75                  80  

Asn Asp Ala Val Trp Thr Ala Val Asn Lys Gly Val Thr Thr Glu Thr 
                85                  90                  95      

Gly Val Lys Phe Asp Thr Glu Val Leu Gln Gly Thr Tyr Arg Leu Val 
            100                 105                 110         

Glu Val Arg Lys Glu Ser Thr Tyr Val Gly Pro Asn Gly Lys Val Leu 
        115                 120                 125             

Thr Gly Met Lys Ala Val Pro Ala Leu Ile Ile Leu Pro Leu Val Asn 
    130                 135                 140                 

Gln Asn Gly Val Val Glu Asn Ala His Val Tyr Pro Lys Asn Ser Glu 
145                 150                 155                 160 

Asp Lys Pro Thr Ala Thr Lys Thr Phe Asp Thr Ala Ala Gly Phe Val 
                165                 170                 175     

Asp Pro Gly Glu Lys Gly Leu Ala Ile Gly Thr Lys Val Pro Tyr Ile 
            180                 185                 190         

Val Thr Thr Thr Ile Pro Lys Asn Ser Thr Leu Ala Thr Ala Phe Trp 
        195                 200                 205             

Ser Asp Glu Met Thr Glu Gly Leu Asp Tyr Asn Gly Asp Val Val Val 
    210                 215                 220                 

Asn Tyr Asn Gly Gln Pro Leu Asp Asn Ser His Tyr Thr Leu Glu Ala 
225                 230                 235                 240 

Gly His Asn Gly Phe Ile Leu Lys Leu Asn Glu Lys Gly Leu Glu Ala 
                245                 250                 255     

Ile Asn Gly Lys Asp Ala Glu Ala Thr Ile Thr Leu Lys Tyr Thr Ala 
            260                 265                 270         

Thr Leu Asn Ala Leu Ala Val Ala Asp Val Pro Glu Ala Asn Asp Val 
        275                 280                 285             

Thr Phe His Tyr Gly Asn Asn Pro Gly His Gly Asn Thr Pro Lys Pro 
    290                 295                 300                 

Asn Lys Pro Lys Asn Gly Glu Leu Thr Ile Thr Lys Thr Trp Ala Asp 
305                 310                 315                 320 

Ala Lys Asp Ala Pro Ile Ala Gly Val Glu Val Thr Phe Asp Leu Val 
                325                 330                 335     

Asn Ala Gln Thr Gly Glu Val Val Lys Val Pro Gly His Glu Thr Gly 
            340                 345                 350         

Ile Val Leu Asn Gln Thr Asn Asn Trp Thr Phe Thr Ala Thr Gly Leu 
        355                 360                 365             

Asp Asn Asn Thr Glu Tyr Lys Phe Val Glu Arg Thr Ile Lys Gly Tyr 
    370                 375                 380                 

Ser Ala Asp Tyr Gln Thr Ile Thr Glu Thr Gly Lys Ile Ala Val Lys 
385                 390                 395                 400 

Asn Trp Lys Asp Glu Asn Pro Glu Pro Ile Asn Pro Glu Glu Pro Arg 
                405                 410                 415     

Val Lys Thr Tyr Gly Lys Lys Phe Val Lys Val Asp Gln Lys Asp Glu 
            420                 425                 430         

Arg Leu Lys Glu Ala Gln Phe Val Val Lys Asn Glu Gln Gly Lys Tyr 
        435                 440                 445             

Leu Ala Leu Lys Ser Ala Ala Gln Gln Ala Val Asn Glu Lys Ala Ala 
    450                 455                 460                 

Ala Glu Ala Lys Gln Ala Leu Asp Ala Ala Ile Ala Ala Tyr Thr Asn 
465                 470                 475                 480 

Ala Ala Asp Lys Asn Ala Ala Gln Ala Val Val Asp Ala Ala Gln Lys 
                485                 490                 495     

Thr Tyr Asn Asp Asn Tyr Arg Ala Ala Arg Phe Gly Tyr Val Glu Val 
            500                 505                 510         

Glu Arg Lys Glu Asp Ala Leu Val Leu Thr Ser Asn Thr Asp Gly Gln 
        515                 520                 525             

Phe Gln Ile Ser Gly Leu Ala Ala Gly Ser Tyr Thr Leu Glu Glu Thr 
    530                 535                 540                 

Lys Ala Pro Glu Gly Phe Ala Lys Leu Gly Asp Val Lys Phe Glu Val 
545                 550                 555                 560 

Gly Ala Gly Ser Trp Asn Gln Gly Asp Phe Asn Tyr Leu Lys Asp Val 
                565                 570                 575     

Gln Lys Asn Asp Ala Thr Lys Val Val Asn Lys Lys Ile Thr Gly Ser 
            580                 585                 590         

Gly Ser Gly Gly Gly Gly Ala Ala Thr Val Phe Ala Ala Gly Thr Thr 
        595                 600                 605             

Thr Thr Ser Val Thr Val His Lys Leu Leu Ala Thr Asp Gly Asp Met 
    610                 615                 620                 

Asp Lys Ile Ala Asn Glu Leu Glu Thr Gly Asn Tyr Ala Gly Asn Lys 
625                 630                 635                 640 

Val Gly Val Leu Pro Ala Asn Ala Lys Glu Ile Ala Gly Val Met Phe 
                645                 650                 655     

Val Trp Thr Asn Thr Asn Asn Glu Ile Ile Asp Glu Asn Gly Gln Thr 
            660                 665                 670         

Leu Gly Val Asn Ile Asp Pro Gln Thr Phe Lys Leu Ser Gly Ala Met 
        675                 680                 685             

Pro Ala Thr Ala Met Lys Lys Leu Thr Glu Ala Glu Gly Ala Lys Phe 
    690                 695                 700                 

Asn Thr Ala Asn Leu Pro Ala Ala Lys Tyr Lys Ile Tyr Glu Ile His 
705                 710                 715                 720 

Ser Leu Ser Thr Tyr Val Gly Glu Asp Gly Ala Thr Leu Thr Gly Ser 
                725                 730                 735     

Lys Ala Val Pro Ile Glu Ile Glu Leu Pro Leu Asn Asp Val Val Asp 
            740                 745                 750         

Ala His Val Tyr Pro Lys Asn Thr Glu Ala Lys Pro Lys Ile Asp Lys 
        755                 760                 765             

Asp Phe Lys Gly Lys Ala Asn Pro Asp Thr Pro Arg Val Asp Lys Asp 
    770                 775                 780                 

Thr Pro Val Asn His Gln Val Gly Asp Val Val Glu Tyr Glu Ile Val 
785                 790                 795                 800 

Thr Lys Ile Pro Ala Leu Ala Asn Tyr Ala Thr Ala Asn Trp Ser Asp 
                805                 810                 815     

Arg Met Thr Glu Gly Leu Ala Phe Asn Lys Gly Thr Val Lys Val Thr 
            820                 825                 830         

Val Asp Asp Val Ala Leu Glu Ala Gly Asp Tyr Ala Leu Thr Glu Val 
        835                 840                 845             

Ala Thr Gly Phe Asp Leu Lys Leu Thr Asp Ala Gly Leu Ala Lys Val 
    850                 855                 860                 

Asn Asp Gln Asn Ala Glu Lys Thr Val Lys Ile Thr Tyr Ser Ala Thr 
865                 870                 875                 880 

Leu Asn Asp Lys Ala Ile Val Glu Val Pro Glu Ser Asn Asp Val Thr 
                885                 890                 895     

Phe Asn Tyr Gly Asn Asn Pro Asp His Gly Asn Thr Pro Lys Pro Asn 
            900                 905                 910         

Lys Pro Asn Glu Asn Gly Asp Leu Thr Leu Thr Lys Thr Trp Val Asp 
        915                 920                 925             

Ala Thr Gly Ala Pro Ile Pro Ala Gly Ala Glu Ala Thr Phe Asp Leu 
    930                 935                 940                 

Val Asn Ala Gln Thr Gly Lys Val Val Gln Thr Val Thr Leu Thr Thr 
945                 950                 955                 960 

Asp Lys Asn Thr Val Thr Val Asn Gly Leu Asp Lys Asn Thr Glu Tyr 
                965                 970                 975     

Lys Phe Val Glu Arg Ser Ile Lys Gly Tyr Ser Ala Asp Tyr Gln Glu 
            980                 985                 990         

Ile Thr Thr Ala Gly Glu Ile Ala Val Lys Asn Trp Lys Asp Glu Asn 
        995                 1000                1005            

Pro Lys Pro Leu Asp Pro Thr Glu Pro Lys Val Val Thr Tyr Gly Lys 
    1010                1015                1020                

Lys Phe Val Lys Val Asn Asp Lys Asp Asn Arg Leu Ala Gly Ala Glu 
1025                1030                1035                1040

Phe Val Ile Ala Asn Ala Asp Asn Ala Gly Gln Tyr Leu Ala Arg Lys 
                1045                1050                1055    

Ala Asp Lys Val Ser Gln Glu Glu Lys Gln Leu Val Val Thr Thr Lys 
            1060                1065                1070        

Asp Ala Leu Asp Arg Ala Val Ala Ala Tyr Asn Ala Leu Thr Ala Gln 
        1075                1080                1085            

Gln Gln Thr Gln Gln Glu Lys Glu Lys Val Asp Lys Ala Gln Ala Ala 
    1090                1095                1100                

Tyr Asn Ala Ala Val Ile Ala Ala Asn Asn Ala Phe Glu Trp Val Ala 
1105                1110                1115                1120

Asp Lys Asp Asn Glu Asn Val Val Lys Leu Val Ser Asp Ala Gln Gly 
                1125                1130                1135    

Arg Phe Glu Ile Thr Gly Leu Leu Ala Gly Thr Tyr Tyr Leu Glu Glu 
            1140                1145                1150        

Thr Lys Gln Pro Ala Gly Tyr Ala Leu Leu Thr Ser Arg Gln Lys Phe 
        1155                1160                1165            

Glu Val Thr Ala Thr Ser Tyr Ser Ala Thr Gly Gln Gly Ile Glu Tyr 
    1170                1175                1180                

Thr Ala Gly Ser Gly Lys Asp Asp Ala Thr Lys Val Val Asn Lys Lys 
1185                1190                1195                1200

Ile Thr Leu Gly Gly Ser Gly Gly Gly Gly Ala Ala Thr Val Phe Ala 
                1205                1210                1215    

Ala Asp Asn Val Ser Thr Ala Pro Asp Ala Val Thr Lys Thr Leu Thr 
            1220                1225                1230        

Ile His Lys Leu Leu Leu Ser Glu Asp Asp Leu Lys Thr Trp Asp Thr 
        1235                1240                1245            

Asn Gly Pro Lys Gly Tyr Asp Gly Thr Gln Ser Ser Leu Lys Asp Leu 
    1250                1255                1260                

Thr Gly Val Val Ala Glu Glu Ile Pro Asn Val Tyr Phe Glu Leu Gln 
1265                1270                1275                1280

Lys Tyr Asn Leu Thr Asp Gly Lys Glu Lys Glu Asn Leu Lys Asp Asp 
                1285                1290                1295    

Ser Lys Trp Thr Thr Val His Gly Gly Leu Thr Thr Lys Asp Gly Leu 
            1300                1305                1310        

Lys Ile Glu Thr Ser Thr Leu Lys Gly Val Tyr Arg Ile Arg Glu Asp 
        1315                1320                1325            

Arg Thr Lys Thr Thr Tyr Val Gly Pro Asn Gly Gln Val Leu Thr Gly 
    1330                1335                1340                

Ser Lys Ala Val Pro Ala Leu Val Thr Leu Pro Leu Val Asn Asn Asn 
1345                1350                1355                1360

Gly Thr Val Ile Asp Ala His Val Phe Pro Lys Asn Ser Tyr Asn Lys 
                1365                1370                1375    

Pro Val Val Asp Lys Arg Ile Ala Asp Thr Leu Asn Tyr Asn Asp Gln 
            1380                1385                1390        

Asn Gly Leu Ser Ile Gly Thr Lys Ile Pro Tyr Val Val Asn Thr Thr 
        1395                1400                1405            

Ile Pro Ser Asn Ala Thr Phe Ala Thr Ser Phe Trp Ser Asp Glu Met 
    1410                1415                1420                

Thr Glu Gly Leu Thr Tyr Asn Glu Asp Val Thr Ile Thr Leu Asn Asn 
1425                1430                1435                1440

Val Ala Met Asp Gln Ala Asp Tyr Glu Val Thr Lys Gly Asn Asn Gly 
                1445                1450                1455    

Phe Asn Leu Lys Leu Thr Glu Ala Gly Leu Ala Lys Ile Asn Gly Lys 
            1460                1465                1470        

Asp Ala Asp Gln Lys Ile Gln Ile Thr Tyr Ser Ala Thr Leu Asn Ser 
        1475                1480                1485            

Leu Ala Val Ala Asp Ile Pro Glu Ser Asn Asp Ile Thr Tyr His Tyr 
    1490                1495                1500                

Gly Asn His Gln Asp His Gly Asn Thr Pro Lys Pro Thr Lys Pro Asn 
1505                1510                1515                1520

Asn Gly Gln Ile Thr Val Thr Lys Thr Trp Asp Ser Gln Pro Ala Pro 
                1525                1530                1535    

Glu Gly Val Lys Ala Thr Val Gln Leu Val Asn Ala Lys Thr Gly Glu 
            1540                1545                1550        

Lys Val Gly Ala Pro Val Glu Leu Ser Glu Asn Asn Trp Thr Tyr Thr 
        1555                1560                1565            

Trp Ser Gly Leu Asp Asn Ser Ile Glu Tyr Lys Val Glu Glu Glu Tyr 
    1570                1575                1580                

Asn Gly Tyr Ser Ala Glu Tyr Thr Val Glu Ser Lys Gly Lys Leu Gly 
1585                1590                1595                1600

Val Lys Asn Trp Lys Asp Asn Asn Pro Ala Pro Ile Asn Pro Glu Glu 
                1605                1610                1615    

Pro Arg Val Lys Thr Tyr Gly Lys Lys Phe Val Lys Val Asp Gln Lys 
            1620                1625                1630        

Asp Thr Arg Leu Glu Asn Ala Gln Phe Val Val Lys Lys Ala Asp Ser 
        1635                1640                1645            

Asn Lys Tyr Ile Ala Phe Lys Ser Thr Ala Gln Gln Ala Ala Asp Glu 
    1650                1655                1660                

Lys Ala Ala Ala Thr Ala Lys Gln Lys Leu Asp Ala Ala Val Ala Ala 
1665                1670                1675                1680

Tyr Thr Asn Ala Ala Asp Lys Gln Ala Ala Gln Ala Leu Val Asp Gln 
                1685                1690                1695    

Ala Gln Gln Glu Tyr Asn Val Ala Tyr Lys Glu Ala Lys Phe Gly Tyr 
            1700                1705                1710        

Val Glu Val Ala Gly Lys Asp Glu Ala Met Val Leu Thr Ser Asn Thr 
        1715                1720                1725            

Asp Gly Gln Phe Gln Ile Ser Gly Leu Ala Ala Gly Thr Tyr Lys Leu 
    1730                1735                1740                

Glu Glu Ile Lys Ala Pro Glu Gly Phe Ala Lys Ile Asp Asp Val Glu 
1745                1750                1755                1760

Phe Val Val Gly Ala Gly Ser Trp Asn Gln Gly Glu Phe Asn Tyr Leu 
                1765                1770                1775    

Lys Asp Val Gln Lys Asn Asp Ala Thr Lys Val Val Asn Lys Lys Ile 
            1780                1785                1790        

Thr Leu Gly His His His His His His 
        1795                1800    

<210>   253
<211>   5403
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Sequence encoding SEQ ID NO: 252

<400>   253
atggctagcg cggaacaaaa aactaagaca cttacagttc ataaattatt gatgacagat   60
caagagcttg acgcttggaa ttctgatgcg attactactg caggttatga cggttcgcaa   120
aattttgaac agttcaaaca acttcaaggt gttccacaag gagtaaccga aatctctggt   180
gttgcattcg agttacagag ttatacgggt cctcaaggaa aagaacaaga aaatttaacg   240
aatgatgcgg tttggactgc ggttaataaa ggtgtgacga ctgaaacggg tgttaaattt   300
gatactgaag ttttacaagg gacatatcgt cttgtcgaag tacgtaaaga atcgacttat   360
gtcggtccaa atggtaaagt tttaacaggt atgaaagctg ttcctgcttt aattattctg   420
ccgcttgtaa accaaaatgg tgttgtagaa aatgcacatg tctatccaaa gaattctgaa   480
gacaaaccta cagcaacgaa aacatttgat actgcagcag gtttcgtaga tccaggtgaa   540
aaaggtttag caattggcac taaggtaccg tatattgtta caacaactat tccgaaaaac   600
tcaactcttg caacagcttt ctggtcagat gaaatgacag aaggtctaga ttataatggt   660
gatgtagttg ttaattataa tggtcaaccg cttgataatt ctcattacac attagaagca   720
ggtcataatg gctttatctt gaagttaaat gaaaaaggtc tggaagcaat caacggtaaa   780
gatgcagaag caacaattac gttgaagtat actgcaactt taaatgctct tgctgttgct   840
gatgtgccag aagcgaatga tgtaacattc cattatggaa acaacccagg tcatggtaac   900
actccaaaac caaacaaacc taaaaacggt gaacttacaa ttactaaaac atgggctgat   960
gctaaagatg ctcctatagc aggtgtagaa gtaacttttg atttggtaaa tgctcagaca   1020
ggtgaggtcg ttaaagtacc tggacatgaa acaggtattg tattgaatca aacaaataat   1080
tggacattta ctgctacagg tcttgataat aatacagaat ataaatttgt tgaacggaca   1140
attaagggat attctgcaga ttaccaaaca attactgaaa caggaaaaat tgctgttaaa   1200
aactggaaag atgaaaatcc agaaccaata aatcctgaag agccacgtgt aaaaacatat   1260
ggtaaaaaat tcgttaaggt tgaccaaaaa gacgaacgct taaaagaagc acaattcgtt   1320
gtgaagaatg agcaagggaa atatcttgca ctcaaatctg cagcacaaca agctgtaaat   1380
gagaaagctg ccgcagaagc gaaacaagcg ctagatgcag cgatagcagc ctatacaaat   1440
gctgcagata aaaatgcagc acaagctgta gtagatgctg cgcaaaaaac atataatgac   1500
aattacagag cagctagatt tggctatgta gaagtagaga gaaaagaaga tgcgttagtt   1560
cttacttcta acactgatgg tcaattccaa atttcaggtc ttgctgctgg aagctacacg   1620
ttggaagaaa caaaagctcc agaaggcttt gcaaaacttg gagatgtgaa gtttgaggtt   1680
ggagcaggtt cttggaatca aggtgatttc aattatttaa aagatgttca gaagaacgac   1740
gctacaaaag tagtcaacaa aaaaatcacg ggatccggca gcggtggcgg tggcgctgca   1800
acagtttttg cggctgggac gacaacaaca tctgttaccg ttcataaact attggcaaca   1860
gatggggata tggataaaat tgcaaatgag ttagaaacag gtaactatgc tggtaataaa   1920
gtgggtgttc tacctgcaaa tgcaaaagaa attgccggtg ttatgttcgt ttggacaaat   1980
actaataatg aaattattga tgaaaatggc caaactctag gagtgaatat tgatccacaa   2040
acatttaaac tctcaggggc aatgccggca actgcaatga aaaaattaac agaagctgaa   2100
ggagctaaat ttaacacggc aaatttacca gctgctaagt ataaaattta tgaaattcac   2160
agtttatcaa cttatgtcgg tgaagatgga gcaaccttaa caggttctaa agcagttcca   2220
attgaaattg aattaccatt gaacgatgtt gtggatgcgc atgtgtatcc aaaaaataca   2280
gaagcaaagc caaaaattga taaagatttc aaaggtaaag caaatccaga tacaccacgt   2340
gtagataaag atacacctgt gaaccaccaa gttggagatg ttgtagagta cgaaattgtt   2400
acaaaaattc cagcacttgc taattatgca acagcaaact ggagcgatag aatgactgaa   2460
ggtttggcat tcaacaaagg tacagtgaaa gtaactgttg atgatgttgc acttgaagca   2520
ggtgattatg ctctaacaga agtagcaact ggttttgatt tgaaattaac agatgctggt   2580
ttagctaaag tgaatgacca aaacgctgaa aaaactgtga aaatcactta ttcggcaaca   2640
ttgaatgaca aagcaattgt agaagtacca gaatctaatg atgtaacatt taactatggt   2700
aataatccag atcacgggaa tactccaaag ccgaataagc caaatgaaaa cggcgatttg   2760
acattgacca agacatgggt tgatgctaca ggtgcaccaa ttccggctgg agctgaagca   2820
acgttcgatt tggttaatgc tcagactggt aaagttgtac aaactgtaac tttgacaaca   2880
gacaaaaata cagttactgt taacggattg gataaaaata cagaatataa attcgttgaa   2940
cgtagtataa aagggtattc agcagattat caagaaatca ctacagctgg agaaattgct   3000
gtcaagaact ggaaagacga aaatccaaaa ccacttgatc caacagagcc aaaagttgtt   3060
acatatggta aaaagtttgt caaagttaat gataaagata atcgtttagc tggggcagaa   3120
tttgtaattg caaatgctga taatgctggt caatatttag cacgtaaagc agataaagtg   3180
agtcaagaag agaagcagtt ggttgttaca acaaaggatg ctttagatag agcagttgct   3240
gcttataacg ctcttactgc acaacaacaa actcagcaag aaaaagagaa agttgacaaa   3300
gctcaagctg cttataatgc tgctgtgatt gctgccaaca atgcatttga atgggtggca   3360
gataaggaca atgaaaatgt tgtgaaatta gtttctgatg cacaaggtcg ctttgaaatt   3420
acaggccttc ttgcaggtac atattactta gaagaaacaa aacagcctgc tggttatgca   3480
ttactaacta gccgtcagaa atttgaagtc actgcaactt cttattcagc gactggacaa   3540
ggcattgagt atactgctgg ttcaggtaaa gatgacgcta caaaagtagt caacaaaaaa   3600
atcactctcg agggcagcgg tggcggtggc gctgcaacag tttttgcggc ggacaatgtt   3660
agtacagcac cagatgctgt tactaaaact ttaacaatcc ataagttact gctctcagaa   3720
gatgatttaa agacttggga tacaaacggt cctaaaggat atgatggaac tcaatctagt   3780
ttaaaagatt taactggagt tgtagctgag gaaattccaa atgtatactt tgaattacaa   3840
aagtataatt tgactgatgg taaggaaaaa gaaaatctta aagatgatag taaatggaca   3900
acagttcatg gtggtttgac aactaaagat ggacttaaaa ttgaaaccag tactcttaaa   3960
ggtgtgtatc gtattcgtga ggatagaaca aagactacct atgttggtcc taatgggcaa   4020
gtattaacag gttcaaaagc cgtacctgct cttgtaactc ttccacttgt taacaataat   4080
ggtacagtaa ttgatgcaca tgttttccct aaaaattcat ataataaacc agttgtagat   4140
aaaagaattg ctgatacttt gaattataac gatcaaaatg gtctgtctat cggtactaaa   4200
atcccatatg ttgttaatac aacaattcca agtaatgcaa catttgcaac ttcattttgg   4260
tcagatgaaa tgacagaagg tctaacttat aatgaagatg taacaattac tttgaataat   4320
gtagctatgg atcaagctga ttatgaagtc actaaaggaa ataatggctt taacttaaaa   4380
ttaacagaag caggtttagc taaaattaat ggtaaggatg cagaccaaaa aatccaaatt   4440
acttactcag ctactttgaa ctcacttgct gttgcagaca ttcctgaaag taacgatatt   4500
acatatcatt acggaaatca tcaagatcat gggaatactc caaaaccaac taaacctaat   4560
aatggtcaaa ttacagtaac taagacatgg gacagtcaac ctgctcctga gggggtgaaa   4620
gcgactgttc aacttgtaaa tgccaagact ggtgagaaag tcggtgctcc tgtagaactt   4680
tcagaaaata attggacata tacttggagt ggtctagata attctattga atacaaagtt   4740
gaagaagaat ataatggata ctcagctgaa tacacagtag agagcaaagg gaagttgggg   4800
gtaaaaaact ggaaagataa taacccagct ccaatcaatc ctgaagaacc acgtgtaaaa   4860
acatacggta aaaagtttgt caaagtagac caaaaagata ctcgtctaga aaatgcgcag   4920
ttcgttgtta aaaaagcaga tagcaataaa tatattgcct ttaagtcaac tgcacaacaa   4980
gctgcagatg aaaaagcagc agcaactgca aaacaaaaat tggatgcagc ggtagcagct   5040
tacacaaatg ctgcagataa gcaagccgct caagctctag tagatcaagc acagcaagaa   5100
tacaatgtag cttacaaaga agccaaattt ggttatgttg aagtagctgg aaaagatgaa   5160
gcaatggttc ttacttctaa tacggatggt caattccaaa tttcaggtct tgctgctggt   5220
acttataaat tagaagaaat taaagctcca gaaggttttg cgaaaattga tgatgtagaa   5280
tttgttgttg gagcaggttc ttggaatcaa ggtgagttta attacttaaa agatgttcaa   5340
aagaatgacg ctacaaaagt agtcaacaaa aaaatcactc tcgagcacca ccaccaccac   5400
cac                                                                 5403

<210>   254
<211>   1801
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   RrgB II-III-I

<400>   254
Met Ala Ser Ala Ala Thr Val Phe Ala Ala Asp Asn Val Ser Thr Ala 
1               5                   10                  15      

Pro Asp Ala Val Thr Lys Thr Leu Thr Ile His Lys Leu Leu Leu Ser 
            20                  25                  30          

Glu Asp Asp Leu Lys Thr Trp Asp Thr Asn Gly Pro Lys Gly Tyr Asp 
        35                  40                  45              

Gly Thr Gln Ser Ser Leu Lys Asp Leu Thr Gly Val Val Ala Glu Glu 
    50                  55                  60                  

Ile Pro Asn Val Tyr Phe Glu Leu Gln Lys Tyr Asn Leu Thr Asp Gly 
65                  70                  75                  80  

Lys Glu Lys Glu Asn Leu Lys Asp Asp Ser Lys Trp Thr Thr Val His 
                85                  90                  95      

Gly Gly Leu Thr Thr Lys Asp Gly Leu Lys Ile Glu Thr Ser Thr Leu 
            100                 105                 110         

Lys Gly Val Tyr Arg Ile Arg Glu Asp Arg Thr Lys Thr Thr Tyr Val 
        115                 120                 125             

Gly Pro Asn Gly Gln Val Leu Thr Gly Ser Lys Ala Val Pro Ala Leu 
    130                 135                 140                 

Val Thr Leu Pro Leu Val Asn Asn Asn Gly Thr Val Ile Asp Ala His 
145                 150                 155                 160 

Val Phe Pro Lys Asn Ser Tyr Asn Lys Pro Val Val Asp Lys Arg Ile 
                165                 170                 175     

Ala Asp Thr Leu Asn Tyr Asn Asp Gln Asn Gly Leu Ser Ile Gly Thr 
            180                 185                 190         

Lys Ile Pro Tyr Val Val Asn Thr Thr Ile Pro Ser Asn Ala Thr Phe 
        195                 200                 205             

Ala Thr Ser Phe Trp Ser Asp Glu Met Thr Glu Gly Leu Thr Tyr Asn 
    210                 215                 220                 

Glu Asp Val Thr Ile Thr Leu Asn Asn Val Ala Met Asp Gln Ala Asp 
225                 230                 235                 240 

Tyr Glu Val Thr Lys Gly Asn Asn Gly Phe Asn Leu Lys Leu Thr Glu 
                245                 250                 255     

Ala Gly Leu Ala Lys Ile Asn Gly Lys Asp Ala Asp Gln Lys Ile Gln 
            260                 265                 270         

Ile Thr Tyr Ser Ala Thr Leu Asn Ser Leu Ala Val Ala Asp Ile Pro 
        275                 280                 285             

Glu Ser Asn Asp Ile Thr Tyr His Tyr Gly Asn His Gln Asp His Gly 
    290                 295                 300                 

Asn Thr Pro Lys Pro Thr Lys Pro Asn Asn Gly Gln Ile Thr Val Thr 
305                 310                 315                 320 

Lys Thr Trp Asp Ser Gln Pro Ala Pro Glu Gly Val Lys Ala Thr Val 
                325                 330                 335     

Gln Leu Val Asn Ala Lys Thr Gly Glu Lys Val Gly Ala Pro Val Glu 
            340                 345                 350         

Leu Ser Glu Asn Asn Trp Thr Tyr Thr Trp Ser Gly Leu Asp Asn Ser 
        355                 360                 365             

Ile Glu Tyr Lys Val Glu Glu Glu Tyr Asn Gly Tyr Ser Ala Glu Tyr 
    370                 375                 380                 

Thr Val Glu Ser Lys Gly Lys Leu Gly Val Lys Asn Trp Lys Asp Asn 
385                 390                 395                 400 

Asn Pro Ala Pro Ile Asn Pro Glu Glu Pro Arg Val Lys Thr Tyr Gly 
                405                 410                 415     

Lys Lys Phe Val Lys Val Asp Gln Lys Asp Thr Arg Leu Glu Asn Ala 
            420                 425                 430         

Gln Phe Val Val Lys Lys Ala Asp Ser Asn Lys Tyr Ile Ala Phe Lys 
        435                 440                 445             

Ser Thr Ala Gln Gln Ala Ala Asp Glu Lys Ala Ala Ala Thr Ala Lys 
    450                 455                 460                 

Gln Lys Leu Asp Ala Ala Val Ala Ala Tyr Thr Asn Ala Ala Asp Lys 
465                 470                 475                 480 

Gln Ala Ala Gln Ala Leu Val Asp Gln Ala Gln Gln Glu Tyr Asn Val 
                485                 490                 495     

Ala Tyr Lys Glu Ala Lys Phe Gly Tyr Val Glu Val Ala Gly Lys Asp 
            500                 505                 510         

Glu Ala Met Val Leu Thr Ser Asn Thr Asp Gly Gln Phe Gln Ile Ser 
        515                 520                 525             

Gly Leu Ala Ala Gly Thr Tyr Lys Leu Glu Glu Ile Lys Ala Pro Glu 
    530                 535                 540                 

Gly Phe Ala Lys Ile Asp Asp Val Glu Phe Val Val Gly Ala Gly Ser 
545                 550                 555                 560 

Trp Asn Gln Gly Glu Phe Asn Tyr Leu Lys Asp Val Gln Lys Asn Asp 
                565                 570                 575     

Ala Thr Lys Val Val Asn Lys Lys Ile Thr Gly Ser Gly Ser Gly Gly 
            580                 585                 590         

Gly Gly Ala Glu Gln Lys Thr Lys Thr Leu Thr Val His Lys Leu Leu 
        595                 600                 605             

Met Thr Asp Gln Glu Leu Asp Ala Trp Asn Ser Asp Ala Ile Thr Thr 
    610                 615                 620                 

Ala Gly Tyr Asp Gly Ser Gln Asn Phe Glu Gln Phe Lys Gln Leu Gln 
625                 630                 635                 640 

Gly Val Pro Gln Gly Val Thr Glu Ile Ser Gly Val Ala Phe Glu Leu 
                645                 650                 655     

Gln Ser Tyr Thr Gly Pro Gln Gly Lys Glu Gln Glu Asn Leu Thr Asn 
            660                 665                 670         

Asp Ala Val Trp Thr Ala Val Asn Lys Gly Val Thr Thr Glu Thr Gly 
        675                 680                 685             

Val Lys Phe Asp Thr Glu Val Leu Gln Gly Thr Tyr Arg Leu Val Glu 
    690                 695                 700                 

Val Arg Lys Glu Ser Thr Tyr Val Gly Pro Asn Gly Lys Val Leu Thr 
705                 710                 715                 720 

Gly Met Lys Ala Val Pro Ala Leu Ile Ile Leu Pro Leu Val Asn Gln 
                725                 730                 735     

Asn Gly Val Val Glu Asn Ala His Val Tyr Pro Lys Asn Ser Glu Asp 
            740                 745                 750         

Lys Pro Thr Ala Thr Lys Thr Phe Asp Thr Ala Ala Gly Phe Val Asp 
        755                 760                 765             

Pro Gly Glu Lys Gly Leu Ala Ile Gly Thr Lys Val Pro Tyr Ile Val 
    770                 775                 780                 

Thr Thr Thr Ile Pro Lys Asn Ser Thr Leu Ala Thr Ala Phe Trp Ser 
785                 790                 795                 800 

Asp Glu Met Thr Glu Gly Leu Asp Tyr Asn Gly Asp Val Val Val Asn 
                805                 810                 815     

Tyr Asn Gly Gln Pro Leu Asp Asn Ser His Tyr Thr Leu Glu Ala Gly 
            820                 825                 830         

His Asn Gly Phe Ile Leu Lys Leu Asn Glu Lys Gly Leu Glu Ala Ile 
        835                 840                 845             

Asn Gly Lys Asp Ala Glu Ala Thr Ile Thr Leu Lys Tyr Thr Ala Thr 
    850                 855                 860                 

Leu Asn Ala Leu Ala Val Ala Asp Val Pro Glu Ala Asn Asp Val Thr 
865                 870                 875                 880 

Phe His Tyr Gly Asn Asn Pro Gly His Gly Asn Thr Pro Lys Pro Asn 
                885                 890                 895     

Lys Pro Lys Asn Gly Glu Leu Thr Ile Thr Lys Thr Trp Ala Asp Ala 
            900                 905                 910         

Lys Asp Ala Pro Ile Ala Gly Val Glu Val Thr Phe Asp Leu Val Asn 
        915                 920                 925             

Ala Gln Thr Gly Glu Val Val Lys Val Pro Gly His Glu Thr Gly Ile 
    930                 935                 940                 

Val Leu Asn Gln Thr Asn Asn Trp Thr Phe Thr Ala Thr Gly Leu Asp 
945                 950                 955                 960 

Asn Asn Thr Glu Tyr Lys Phe Val Glu Arg Thr Ile Lys Gly Tyr Ser 
                965                 970                 975     

Ala Asp Tyr Gln Thr Ile Thr Glu Thr Gly Lys Ile Ala Val Lys Asn 
            980                 985                 990         

Trp Lys Asp Glu Asn Pro Glu Pro Ile Asn Pro Glu Glu Pro Arg Val 
        995                 1000                1005            

Lys Thr Tyr Gly Lys Lys Phe Val Lys Val Asp Gln Lys Asp Glu Arg 
    1010                1015                1020                

Leu Lys Glu Ala Gln Phe Val Val Lys Asn Glu Gln Gly Lys Tyr Leu 
1025                1030                1035                1040

Ala Leu Lys Ser Ala Ala Gln Gln Ala Val Asn Glu Lys Ala Ala Ala 
                1045                1050                1055    

Glu Ala Lys Gln Ala Leu Asp Ala Ala Ile Ala Ala Tyr Thr Asn Ala 
            1060                1065                1070        

Ala Asp Lys Asn Ala Ala Gln Ala Val Val Asp Ala Ala Gln Lys Thr 
        1075                1080                1085            

Tyr Asn Asp Asn Tyr Arg Ala Ala Arg Phe Gly Tyr Val Glu Val Glu 
    1090                1095                1100                

Arg Lys Glu Asp Ala Leu Val Leu Thr Ser Asn Thr Asp Gly Gln Phe 
1105                1110                1115                1120

Gln Ile Ser Gly Leu Ala Ala Gly Ser Tyr Thr Leu Glu Glu Thr Lys 
                1125                1130                1135    

Ala Pro Glu Gly Phe Ala Lys Leu Gly Asp Val Lys Phe Glu Val Gly 
            1140                1145                1150        

Ala Gly Ser Trp Asn Gln Gly Asp Phe Asn Tyr Leu Lys Asp Val Gln 
        1155                1160                1165            

Lys Asn Asp Ala Thr Lys Val Val Asn Lys Lys Ile Thr Leu Gly Gly 
    1170                1175                1180                

Ser Gly Gly Gly Gly Ala Ala Thr Val Phe Ala Ala Gly Thr Thr Thr 
1185                1190                1195                1200

Thr Ser Val Thr Val His Lys Leu Leu Ala Thr Asp Gly Asp Met Asp 
                1205                1210                1215    

Lys Ile Ala Asn Glu Leu Glu Thr Gly Asn Tyr Ala Gly Asn Lys Val 
            1220                1225                1230        

Gly Val Leu Pro Ala Asn Ala Lys Glu Ile Ala Gly Val Met Phe Val 
        1235                1240                1245            

Trp Thr Asn Thr Asn Asn Glu Ile Ile Asp Glu Asn Gly Gln Thr Leu 
    1250                1255                1260                

Gly Val Asn Ile Asp Pro Gln Thr Phe Lys Leu Ser Gly Ala Met Pro 
1265                1270                1275                1280

Ala Thr Ala Met Lys Lys Leu Thr Glu Ala Glu Gly Ala Lys Phe Asn 
                1285                1290                1295    

Thr Ala Asn Leu Pro Ala Ala Lys Tyr Lys Ile Tyr Glu Ile His Ser 
            1300                1305                1310        

Leu Ser Thr Tyr Val Gly Glu Asp Gly Ala Thr Leu Thr Gly Ser Lys 
        1315                1320                1325            

Ala Val Pro Ile Glu Ile Glu Leu Pro Leu Asn Asp Val Val Asp Ala 
    1330                1335                1340                

His Val Tyr Pro Lys Asn Thr Glu Ala Lys Pro Lys Ile Asp Lys Asp 
1345                1350                1355                1360

Phe Lys Gly Lys Ala Asn Pro Asp Thr Pro Arg Val Asp Lys Asp Thr 
                1365                1370                1375    

Pro Val Asn His Gln Val Gly Asp Val Val Glu Tyr Glu Ile Val Thr 
            1380                1385                1390        

Lys Ile Pro Ala Leu Ala Asn Tyr Ala Thr Ala Asn Trp Ser Asp Arg 
        1395                1400                1405            

Met Thr Glu Gly Leu Ala Phe Asn Lys Gly Thr Val Lys Val Thr Val 
    1410                1415                1420                

Asp Asp Val Ala Leu Glu Ala Gly Asp Tyr Ala Leu Thr Glu Val Ala 
1425                1430                1435                1440

Thr Gly Phe Asp Leu Lys Leu Thr Asp Ala Gly Leu Ala Lys Val Asn 
                1445                1450                1455    

Asp Gln Asn Ala Glu Lys Thr Val Lys Ile Thr Tyr Ser Ala Thr Leu 
            1460                1465                1470        

Asn Asp Lys Ala Ile Val Glu Val Pro Glu Ser Asn Asp Val Thr Phe 
        1475                1480                1485            

Asn Tyr Gly Asn Asn Pro Asp His Gly Asn Thr Pro Lys Pro Asn Lys 
    1490                1495                1500                

Pro Asn Glu Asn Gly Asp Leu Thr Leu Thr Lys Thr Trp Val Asp Ala 
1505                1510                1515                1520

Thr Gly Ala Pro Ile Pro Ala Gly Ala Glu Ala Thr Phe Asp Leu Val 
                1525                1530                1535    

Asn Ala Gln Thr Gly Lys Val Val Gln Thr Val Thr Leu Thr Thr Asp 
            1540                1545                1550        

Lys Asn Thr Val Thr Val Asn Gly Leu Asp Lys Asn Thr Glu Tyr Lys 
        1555                1560                1565            

Phe Val Glu Arg Ser Ile Lys Gly Tyr Ser Ala Asp Tyr Gln Glu Ile 
    1570                1575                1580                

Thr Thr Ala Gly Glu Ile Ala Val Lys Asn Trp Lys Asp Glu Asn Pro 
1585                1590                1595                1600

Lys Pro Leu Asp Pro Thr Glu Pro Lys Val Val Thr Tyr Gly Lys Lys 
                1605                1610                1615    

Phe Val Lys Val Asn Asp Lys Asp Asn Arg Leu Ala Gly Ala Glu Phe 
            1620                1625                1630        

Val Ile Ala Asn Ala Asp Asn Ala Gly Gln Tyr Leu Ala Arg Lys Ala 
        1635                1640                1645            

Asp Lys Val Ser Gln Glu Glu Lys Gln Leu Val Val Thr Thr Lys Asp 
    1650                1655                1660                

Ala Leu Asp Arg Ala Val Ala Ala Tyr Asn Ala Leu Thr Ala Gln Gln 
1665                1670                1675                1680

Gln Thr Gln Gln Glu Lys Glu Lys Val Asp Lys Ala Gln Ala Ala Tyr 
                1685                1690                1695    

Asn Ala Ala Val Ile Ala Ala Asn Asn Ala Phe Glu Trp Val Ala Asp 
            1700                1705                1710        

Lys Asp Asn Glu Asn Val Val Lys Leu Val Ser Asp Ala Gln Gly Arg 
        1715                1720                1725            

Phe Glu Ile Thr Gly Leu Leu Ala Gly Thr Tyr Tyr Leu Glu Glu Thr 
    1730                1735                1740                

Lys Gln Pro Ala Gly Tyr Ala Leu Leu Thr Ser Arg Gln Lys Phe Glu 
1745                1750                1755                1760

Val Thr Ala Thr Ser Tyr Ser Ala Thr Gly Gln Gly Ile Glu Tyr Thr 
                1765                1770                1775    

Ala Gly Ser Gly Lys Asp Asp Ala Thr Lys Val Val Asn Lys Lys Ile 
            1780                1785                1790        

Thr Leu Gly His His His His His His 
        1795                1800    

<210>   255
<211>   5403
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Sequence encoding SEQ ID NO: 254

<400>   255
atggctagcg ctgcaacagt ttttgcggcg gacaatgtta gtacagcacc agatgctgtt   60
actaaaactt taacaatcca taagttactg ctctcagaag atgatttaaa gacttgggat   120
acaaacggtc ctaaaggata tgatggaact caatctagtt taaaagattt aactggagtt   180
gtagctgagg aaattccaaa tgtatacttt gaattacaaa agtataattt gactgatggt   240
aaggaaaaag aaaatcttaa agatgatagt aaatggacaa cagttcatgg tggtttgaca   300
actaaagatg gacttaaaat tgaaaccagt actcttaaag gtgtgtatcg tattcgtgag   360
gatagaacaa agactaccta tgttggtcct aatgggcaag tattaacagg ttcaaaagcc   420
gtacctgctc ttgtaactct tccacttgtt aacaataatg gtacagtaat tgatgcacat   480
gttttcccta aaaattcata taataaacca gttgtagata aaagaattgc tgatactttg   540
aattataacg atcaaaatgg tctgtctatc ggtactaaaa tcccatatgt tgttaataca   600
acaattccaa gtaatgcaac atttgcaact tcattttggt cagatgaaat gacagaaggt   660
ctaacttata atgaagatgt aacaattact ttgaataatg tagctatgga tcaagctgat   720
tatgaagtca ctaaaggaaa taatggcttt aacttaaaat taacagaagc aggtttagct   780
aaaattaatg gtaaggatgc agaccaaaaa atccaaatta cttactcagc tactttgaac   840
tcacttgctg ttgcagacat tcctgaaagt aacgatatta catatcatta cggaaatcat   900
caagatcatg ggaatactcc aaaaccaact aaacctaata atggtcaaat tacagtaact   960
aagacatggg acagtcaacc tgctcctgag ggggtgaaag cgactgttca acttgtaaat   1020
gccaagactg gtgagaaagt cggtgctcct gtagaacttt cagaaaataa ttggacatat   1080
acttggagtg gtctagataa ttctattgaa tacaaagttg aagaagaata taatggatac   1140
tcagctgaat acacagtaga gagcaaaggg aagttggggg taaaaaactg gaaagataat   1200
aacccagctc caatcaatcc tgaagaacca cgtgtaaaaa catacggtaa aaagtttgtc   1260
aaagtagacc aaaaagatac tcgtctagaa aatgcgcagt tcgttgttaa aaaagcagat   1320
agcaataaat atattgcctt taagtcaact gcacaacaag ctgcagatga aaaagcagca   1380
gcaactgcaa aacaaaaatt ggatgcagcg gtagcagctt acacaaatgc tgcagataag   1440
caagccgctc aagctctagt agatcaagca cagcaagaat acaatgtagc ttacaaagaa   1500
gccaaatttg gttatgttga agtagctgga aaagatgaag caatggttct tacttctaat   1560
acggatggtc aattccaaat ttcaggtctt gctgctggta cttataaatt agaagaaatt   1620
aaagctccag aaggttttgc gaaaattgat gatgtagaat ttgttgttgg agcaggttct   1680
tggaatcaag gtgagtttaa ttacttaaaa gatgttcaaa agaatgacgc tacaaaagta   1740
gtcaacaaaa aaatcactgg atccggcagc ggtggcggtg gcgcggaaca aaaaactaag   1800
acacttacag ttcataaatt attgatgaca gatcaagagc ttgacgcttg gaattctgat   1860
gcgattacta ctgcaggtta tgacggttcg caaaattttg aacagttcaa acaacttcaa   1920
ggtgttccac aaggagtaac cgaaatctct ggtgttgcat tcgagttaca gagttatacg   1980
ggtcctcaag gaaaagaaca agaaaattta acgaatgatg cggtttggac tgcggttaat   2040
aaaggtgtga cgactgaaac gggtgttaaa tttgatactg aagttttaca agggacatat   2100
cgtcttgtcg aagtacgtaa agaatcgact tatgtcggtc caaatggtaa agttttaaca   2160
ggtatgaaag ctgttcctgc tttaattatt ctgccgcttg taaaccaaaa tggtgttgta   2220
gaaaatgcac atgtctatcc aaagaattct gaagacaaac ctacagcaac gaaaacattt   2280
gatactgcag caggtttcgt agatccaggt gaaaaaggtt tagcaattgg cactaaggta   2340
ccgtatattg ttacaacaac tattccgaaa aactcaactc ttgcaacagc tttctggtca   2400
gatgaaatga cagaaggtct agattataat ggtgatgtag ttgttaatta taatggtcaa   2460
ccgcttgata attctcatta cacattagaa gcaggtcata atggctttat cttgaagtta   2520
aatgaaaaag gtctggaagc aatcaacggt aaagatgcag aagcaacaat tacgttgaag   2580
tatactgcaa ctttaaatgc tcttgctgtt gctgatgtgc cagaagcgaa tgatgtaaca   2640
ttccattatg gaaacaaccc aggtcatggt aacactccaa aaccaaacaa acctaaaaac   2700
ggtgaactta caattactaa aacatgggct gatgctaaag atgctcctat agcaggtgta   2760
gaagtaactt ttgatttggt aaatgctcag acaggtgagg tcgttaaagt acctggacat   2820
gaaacaggta ttgtattgaa tcaaacaaat aattggacat ttactgctac aggtcttgat   2880
aataatacag aatataaatt tgttgaacgg acaattaagg gatattctgc agattaccaa   2940
acaattactg aaacaggaaa aattgctgtt aaaaactgga aagatgaaaa tccagaacca   3000
ataaatcctg aagagccacg tgtaaaaaca tatggtaaaa aattcgttaa ggttgaccaa   3060
aaagacgaac gcttaaaaga agcacaattc gttgtgaaga atgagcaagg gaaatatctt   3120
gcactcaaat ctgcagcaca acaagctgta aatgagaaag ctgccgcaga agcgaaacaa   3180
gcgctagatg cagcgatagc agcctataca aatgctgcag ataaaaatgc agcacaagct   3240
gtagtagatg ctgcgcaaaa aacatataat gacaattaca gagcagctag atttggctat   3300
gtagaagtag agagaaaaga agatgcgtta gttcttactt ctaacactga tggtcaattc   3360
caaatttcag gtcttgctgc tggaagctac acgttggaag aaacaaaagc tccagaaggc   3420
tttgcaaaac ttggagatgt gaagtttgag gttggagcag gttcttggaa tcaaggtgat   3480
ttcaattatt taaaagatgt tcagaagaac gacgctacaa aagtagtcaa caaaaaaatc   3540
acgctcgagg gcagcggtgg cggtggcgct gcaacagttt ttgcggctgg gacgacaaca   3600
acatctgtta ccgttcataa actattggca acagatgggg atatggataa aattgcaaat   3660
gagttagaaa caggtaacta tgctggtaat aaagtgggtg ttctacctgc aaatgcaaaa   3720
gaaattgccg gtgttatgtt cgtttggaca aatactaata atgaaattat tgatgaaaat   3780
ggccaaactc taggagtgaa tattgatcca caaacattta aactctcagg ggcaatgccg   3840
gcaactgcaa tgaaaaaatt aacagaagct gaaggagcta aatttaacac ggcaaattta   3900
ccagctgcta agtataaaat ttatgaaatt cacagtttat caacttatgt cggtgaagat   3960
ggagcaacct taacaggttc taaagcagtt ccaattgaaa ttgaattacc attgaacgat   4020
gttgtggatg cgcatgtgta tccaaaaaat acagaagcaa agccaaaaat tgataaagat   4080
ttcaaaggta aagcaaatcc agatacacca cgtgtagata aagatacacc tgtgaaccac   4140
caagttggag atgttgtaga gtacgaaatt gttacaaaaa ttccagcact tgctaattat   4200
gcaacagcaa actggagcga tagaatgact gaaggtttgg cattcaacaa aggtacagtg   4260
aaagtaactg ttgatgatgt tgcacttgaa gcaggtgatt atgctctaac agaagtagca   4320
actggttttg atttgaaatt aacagatgct ggtttagcta aagtgaatga ccaaaacgct   4380
gaaaaaactg tgaaaatcac ttattcggca acattgaatg acaaagcaat tgtagaagta   4440
ccagaatcta atgatgtaac atttaactat ggtaataatc cagatcacgg gaatactcca   4500
aagccgaata agccaaatga aaacggcgat ttgacattga ccaagacatg ggttgatgct   4560
acaggtgcac caattccggc tggagctgaa gcaacgttcg atttggttaa tgctcagact   4620
ggtaaagttg tacaaactgt aactttgaca acagacaaaa atacagttac tgttaacgga   4680
ttggataaaa atacagaata taaattcgtt gaacgtagta taaaagggta ttcagcagat   4740
tatcaagaaa tcactacagc tggagaaatt gctgtcaaga actggaaaga cgaaaatcca   4800
aaaccacttg atccaacaga gccaaaagtt gttacatatg gtaaaaagtt tgtcaaagtt   4860
aatgataaag ataatcgttt agctggggca gaatttgtaa ttgcaaatgc tgataatgct   4920
ggtcaatatt tagcacgtaa agcagataaa gtgagtcaag aagagaagca gttggttgtt   4980
acaacaaagg atgctttaga tagagcagtt gctgcttata acgctcttac tgcacaacaa   5040
caaactcagc aagaaaaaga gaaagttgac aaagctcaag ctgcttataa tgctgctgtg   5100
attgctgcca acaatgcatt tgaatgggtg gcagataagg acaatgaaaa tgttgtgaaa   5160
ttagtttctg atgcacaagg tcgctttgaa attacaggcc ttcttgcagg tacatattac   5220
ttagaagaaa caaaacagcc tgctggttat gcattactaa ctagccgtca gaaatttgaa   5280
gtcactgcaa cttcttattc agcgactgga caaggcattg agtatactgc tggttcaggt   5340
aaagatgacg ctacaaaagt agtcaacaaa aaaatcactc tcgagcacca ccaccaccac   5400
cac                                                                 5403

<210>   256
<211>   1801
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   RrgB II-I-III

<400>   256
Met Ala Ser Ala Ala Thr Val Phe Ala Ala Asp Asn Val Ser Thr Ala 
1               5                   10                  15      

Pro Asp Ala Val Thr Lys Thr Leu Thr Ile His Lys Leu Leu Leu Ser 
            20                  25                  30          

Glu Asp Asp Leu Lys Thr Trp Asp Thr Asn Gly Pro Lys Gly Tyr Asp 
        35                  40                  45              

Gly Thr Gln Ser Ser Leu Lys Asp Leu Thr Gly Val Val Ala Glu Glu 
    50                  55                  60                  

Ile Pro Asn Val Tyr Phe Glu Leu Gln Lys Tyr Asn Leu Thr Asp Gly 
65                  70                  75                  80  

Lys Glu Lys Glu Asn Leu Lys Asp Asp Ser Lys Trp Thr Thr Val His 
                85                  90                  95      

Gly Gly Leu Thr Thr Lys Asp Gly Leu Lys Ile Glu Thr Ser Thr Leu 
            100                 105                 110         

Lys Gly Val Tyr Arg Ile Arg Glu Asp Arg Thr Lys Thr Thr Tyr Val 
        115                 120                 125             

Gly Pro Asn Gly Gln Val Leu Thr Gly Ser Lys Ala Val Pro Ala Leu 
    130                 135                 140                 

Val Thr Leu Pro Leu Val Asn Asn Asn Gly Thr Val Ile Asp Ala His 
145                 150                 155                 160 

Val Phe Pro Lys Asn Ser Tyr Asn Lys Pro Val Val Asp Lys Arg Ile 
                165                 170                 175     

Ala Asp Thr Leu Asn Tyr Asn Asp Gln Asn Gly Leu Ser Ile Gly Thr 
            180                 185                 190         

Lys Ile Pro Tyr Val Val Asn Thr Thr Ile Pro Ser Asn Ala Thr Phe 
        195                 200                 205             

Ala Thr Ser Phe Trp Ser Asp Glu Met Thr Glu Gly Leu Thr Tyr Asn 
    210                 215                 220                 

Glu Asp Val Thr Ile Thr Leu Asn Asn Val Ala Met Asp Gln Ala Asp 
225                 230                 235                 240 

Tyr Glu Val Thr Lys Gly Asn Asn Gly Phe Asn Leu Lys Leu Thr Glu 
                245                 250                 255     

Ala Gly Leu Ala Lys Ile Asn Gly Lys Asp Ala Asp Gln Lys Ile Gln 
            260                 265                 270         

Ile Thr Tyr Ser Ala Thr Leu Asn Ser Leu Ala Val Ala Asp Ile Pro 
        275                 280                 285             

Glu Ser Asn Asp Ile Thr Tyr His Tyr Gly Asn His Gln Asp His Gly 
    290                 295                 300                 

Asn Thr Pro Lys Pro Thr Lys Pro Asn Asn Gly Gln Ile Thr Val Thr 
305                 310                 315                 320 

Lys Thr Trp Asp Ser Gln Pro Ala Pro Glu Gly Val Lys Ala Thr Val 
                325                 330                 335     

Gln Leu Val Asn Ala Lys Thr Gly Glu Lys Val Gly Ala Pro Val Glu 
            340                 345                 350         

Leu Ser Glu Asn Asn Trp Thr Tyr Thr Trp Ser Gly Leu Asp Asn Ser 
        355                 360                 365             

Ile Glu Tyr Lys Val Glu Glu Glu Tyr Asn Gly Tyr Ser Ala Glu Tyr 
    370                 375                 380                 

Thr Val Glu Ser Lys Gly Lys Leu Gly Val Lys Asn Trp Lys Asp Asn 
385                 390                 395                 400 

Asn Pro Ala Pro Ile Asn Pro Glu Glu Pro Arg Val Lys Thr Tyr Gly 
                405                 410                 415     

Lys Lys Phe Val Lys Val Asp Gln Lys Asp Thr Arg Leu Glu Asn Ala 
            420                 425                 430         

Gln Phe Val Val Lys Lys Ala Asp Ser Asn Lys Tyr Ile Ala Phe Lys 
        435                 440                 445             

Ser Thr Ala Gln Gln Ala Ala Asp Glu Lys Ala Ala Ala Thr Ala Lys 
    450                 455                 460                 

Gln Lys Leu Asp Ala Ala Val Ala Ala Tyr Thr Asn Ala Ala Asp Lys 
465                 470                 475                 480 

Gln Ala Ala Gln Ala Leu Val Asp Gln Ala Gln Gln Glu Tyr Asn Val 
                485                 490                 495     

Ala Tyr Lys Glu Ala Lys Phe Gly Tyr Val Glu Val Ala Gly Lys Asp 
            500                 505                 510         

Glu Ala Met Val Leu Thr Ser Asn Thr Asp Gly Gln Phe Gln Ile Ser 
        515                 520                 525             

Gly Leu Ala Ala Gly Thr Tyr Lys Leu Glu Glu Ile Lys Ala Pro Glu 
    530                 535                 540                 

Gly Phe Ala Lys Ile Asp Asp Val Glu Phe Val Val Gly Ala Gly Ser 
545                 550                 555                 560 

Trp Asn Gln Gly Glu Phe Asn Tyr Leu Lys Asp Val Gln Lys Asn Asp 
                565                 570                 575     

Ala Thr Lys Val Val Asn Lys Lys Ile Thr Gly Ser Gly Ser Gly Gly 
            580                 585                 590         

Gly Gly Ala Ala Thr Val Phe Ala Ala Gly Thr Thr Thr Thr Ser Val 
        595                 600                 605             

Thr Val His Lys Leu Leu Ala Thr Asp Gly Asp Met Asp Lys Ile Ala 
    610                 615                 620                 

Asn Glu Leu Glu Thr Gly Asn Tyr Ala Gly Asn Lys Val Gly Val Leu 
625                 630                 635                 640 

Pro Ala Asn Ala Lys Glu Ile Ala Gly Val Met Phe Val Trp Thr Asn 
                645                 650                 655     

Thr Asn Asn Glu Ile Ile Asp Glu Asn Gly Gln Thr Leu Gly Val Asn 
            660                 665                 670         

Ile Asp Pro Gln Thr Phe Lys Leu Ser Gly Ala Met Pro Ala Thr Ala 
        675                 680                 685             

Met Lys Lys Leu Thr Glu Ala Glu Gly Ala Lys Phe Asn Thr Ala Asn 
    690                 695                 700                 

Leu Pro Ala Ala Lys Tyr Lys Ile Tyr Glu Ile His Ser Leu Ser Thr 
705                 710                 715                 720 

Tyr Val Gly Glu Asp Gly Ala Thr Leu Thr Gly Ser Lys Ala Val Pro 
                725                 730                 735     

Ile Glu Ile Glu Leu Pro Leu Asn Asp Val Val Asp Ala His Val Tyr 
            740                 745                 750         

Pro Lys Asn Thr Glu Ala Lys Pro Lys Ile Asp Lys Asp Phe Lys Gly 
        755                 760                 765             

Lys Ala Asn Pro Asp Thr Pro Arg Val Asp Lys Asp Thr Pro Val Asn 
    770                 775                 780                 

His Gln Val Gly Asp Val Val Glu Tyr Glu Ile Val Thr Lys Ile Pro 
785                 790                 795                 800 

Ala Leu Ala Asn Tyr Ala Thr Ala Asn Trp Ser Asp Arg Met Thr Glu 
                805                 810                 815     

Gly Leu Ala Phe Asn Lys Gly Thr Val Lys Val Thr Val Asp Asp Val 
            820                 825                 830         

Ala Leu Glu Ala Gly Asp Tyr Ala Leu Thr Glu Val Ala Thr Gly Phe 
        835                 840                 845             

Asp Leu Lys Leu Thr Asp Ala Gly Leu Ala Lys Val Asn Asp Gln Asn 
    850                 855                 860                 

Ala Glu Lys Thr Val Lys Ile Thr Tyr Ser Ala Thr Leu Asn Asp Lys 
865                 870                 875                 880 

Ala Ile Val Glu Val Pro Glu Ser Asn Asp Val Thr Phe Asn Tyr Gly 
                885                 890                 895     

Asn Asn Pro Asp His Gly Asn Thr Pro Lys Pro Asn Lys Pro Asn Glu 
            900                 905                 910         

Asn Gly Asp Leu Thr Leu Thr Lys Thr Trp Val Asp Ala Thr Gly Ala 
        915                 920                 925             

Pro Ile Pro Ala Gly Ala Glu Ala Thr Phe Asp Leu Val Asn Ala Gln 
    930                 935                 940                 

Thr Gly Lys Val Val Gln Thr Val Thr Leu Thr Thr Asp Lys Asn Thr 
945                 950                 955                 960 

Val Thr Val Asn Gly Leu Asp Lys Asn Thr Glu Tyr Lys Phe Val Glu 
                965                 970                 975     

Arg Ser Ile Lys Gly Tyr Ser Ala Asp Tyr Gln Glu Ile Thr Thr Ala 
            980                 985                 990         

Gly Glu Ile Ala Val Lys Asn Trp Lys Asp Glu Asn Pro Lys Pro Leu 
        995                 1000                1005            

Asp Pro Thr Glu Pro Lys Val Val Thr Tyr Gly Lys Lys Phe Val Lys 
    1010                1015                1020                

Val Asn Asp Lys Asp Asn Arg Leu Ala Gly Ala Glu Phe Val Ile Ala 
1025                1030                1035                1040

Asn Ala Asp Asn Ala Gly Gln Tyr Leu Ala Arg Lys Ala Asp Lys Val 
                1045                1050                1055    

Ser Gln Glu Glu Lys Gln Leu Val Val Thr Thr Lys Asp Ala Leu Asp 
            1060                1065                1070        

Arg Ala Val Ala Ala Tyr Asn Ala Leu Thr Ala Gln Gln Gln Thr Gln 
        1075                1080                1085            

Gln Glu Lys Glu Lys Val Asp Lys Ala Gln Ala Ala Tyr Asn Ala Ala 
    1090                1095                1100                

Val Ile Ala Ala Asn Asn Ala Phe Glu Trp Val Ala Asp Lys Asp Asn 
1105                1110                1115                1120

Glu Asn Val Val Lys Leu Val Ser Asp Ala Gln Gly Arg Phe Glu Ile 
                1125                1130                1135    

Thr Gly Leu Leu Ala Gly Thr Tyr Tyr Leu Glu Glu Thr Lys Gln Pro 
            1140                1145                1150        

Ala Gly Tyr Ala Leu Leu Thr Ser Arg Gln Lys Phe Glu Val Thr Ala 
        1155                1160                1165            

Thr Ser Tyr Ser Ala Thr Gly Gln Gly Ile Glu Tyr Thr Ala Gly Ser 
    1170                1175                1180                

Gly Lys Asp Asp Ala Thr Lys Val Val Asn Lys Lys Ile Thr Leu Gly 
1185                1190                1195                1200

Gly Ser Gly Gly Gly Gly Ala Glu Gln Lys Thr Lys Thr Leu Thr Val 
                1205                1210                1215    

His Lys Leu Leu Met Thr Asp Gln Glu Leu Asp Ala Trp Asn Ser Asp 
            1220                1225                1230        

Ala Ile Thr Thr Ala Gly Tyr Asp Gly Ser Gln Asn Phe Glu Gln Phe 
        1235                1240                1245            

Lys Gln Leu Gln Gly Val Pro Gln Gly Val Thr Glu Ile Ser Gly Val 
    1250                1255                1260                

Ala Phe Glu Leu Gln Ser Tyr Thr Gly Pro Gln Gly Lys Glu Gln Glu 
1265                1270                1275                1280

Asn Leu Thr Asn Asp Ala Val Trp Thr Ala Val Asn Lys Gly Val Thr 
                1285                1290                1295    

Thr Glu Thr Gly Val Lys Phe Asp Thr Glu Val Leu Gln Gly Thr Tyr 
            1300                1305                1310        

Arg Leu Val Glu Val Arg Lys Glu Ser Thr Tyr Val Gly Pro Asn Gly 
        1315                1320                1325            

Lys Val Leu Thr Gly Met Lys Ala Val Pro Ala Leu Ile Ile Leu Pro 
    1330                1335                1340                

Leu Val Asn Gln Asn Gly Val Val Glu Asn Ala His Val Tyr Pro Lys 
1345                1350                1355                1360

Asn Ser Glu Asp Lys Pro Thr Ala Thr Lys Thr Phe Asp Thr Ala Ala 
                1365                1370                1375    

Gly Phe Val Asp Pro Gly Glu Lys Gly Leu Ala Ile Gly Thr Lys Val 
            1380                1385                1390        

Pro Tyr Ile Val Thr Thr Thr Ile Pro Lys Asn Ser Thr Leu Ala Thr 
        1395                1400                1405            

Ala Phe Trp Ser Asp Glu Met Thr Glu Gly Leu Asp Tyr Asn Gly Asp 
    1410                1415                1420                

Val Val Val Asn Tyr Asn Gly Gln Pro Leu Asp Asn Ser His Tyr Thr 
1425                1430                1435                1440

Leu Glu Ala Gly His Asn Gly Phe Ile Leu Lys Leu Asn Glu Lys Gly 
                1445                1450                1455    

Leu Glu Ala Ile Asn Gly Lys Asp Ala Glu Ala Thr Ile Thr Leu Lys 
            1460                1465                1470        

Tyr Thr Ala Thr Leu Asn Ala Leu Ala Val Ala Asp Val Pro Glu Ala 
        1475                1480                1485            

Asn Asp Val Thr Phe His Tyr Gly Asn Asn Pro Gly His Gly Asn Thr 
    1490                1495                1500                

Pro Lys Pro Asn Lys Pro Lys Asn Gly Glu Leu Thr Ile Thr Lys Thr 
1505                1510                1515                1520

Trp Ala Asp Ala Lys Asp Ala Pro Ile Ala Gly Val Glu Val Thr Phe 
                1525                1530                1535    

Asp Leu Val Asn Ala Gln Thr Gly Glu Val Val Lys Val Pro Gly His 
            1540                1545                1550        

Glu Thr Gly Ile Val Leu Asn Gln Thr Asn Asn Trp Thr Phe Thr Ala 
        1555                1560                1565            

Thr Gly Leu Asp Asn Asn Thr Glu Tyr Lys Phe Val Glu Arg Thr Ile 
    1570                1575                1580                

Lys Gly Tyr Ser Ala Asp Tyr Gln Thr Ile Thr Glu Thr Gly Lys Ile 
1585                1590                1595                1600

Ala Val Lys Asn Trp Lys Asp Glu Asn Pro Glu Pro Ile Asn Pro Glu 
                1605                1610                1615    

Glu Pro Arg Val Lys Thr Tyr Gly Lys Lys Phe Val Lys Val Asp Gln 
            1620                1625                1630        

Lys Asp Glu Arg Leu Lys Glu Ala Gln Phe Val Val Lys Asn Glu Gln 
        1635                1640                1645            

Gly Lys Tyr Leu Ala Leu Lys Ser Ala Ala Gln Gln Ala Val Asn Glu 
    1650                1655                1660                

Lys Ala Ala Ala Glu Ala Lys Gln Ala Leu Asp Ala Ala Ile Ala Ala 
1665                1670                1675                1680

Tyr Thr Asn Ala Ala Asp Lys Asn Ala Ala Gln Ala Val Val Asp Ala 
                1685                1690                1695    

Ala Gln Lys Thr Tyr Asn Asp Asn Tyr Arg Ala Ala Arg Phe Gly Tyr 
            1700                1705                1710        

Val Glu Val Glu Arg Lys Glu Asp Ala Leu Val Leu Thr Ser Asn Thr 
        1715                1720                1725            

Asp Gly Gln Phe Gln Ile Ser Gly Leu Ala Ala Gly Ser Tyr Thr Leu 
    1730                1735                1740                

Glu Glu Thr Lys Ala Pro Glu Gly Phe Ala Lys Leu Gly Asp Val Lys 
1745                1750                1755                1760

Phe Glu Val Gly Ala Gly Ser Trp Asn Gln Gly Asp Phe Asn Tyr Leu 
                1765                1770                1775    

Lys Asp Val Gln Lys Asn Asp Ala Thr Lys Val Val Asn Lys Lys Ile 
            1780                1785                1790        

Thr Leu Gly His His His His His His 
        1795                1800    

<210>   257
<211>   5403
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Sequence encoding SEQ ID NO: 256

<400>   257
atggctagcg ctgcaacagt ttttgcggcg gacaatgtta gtacagcacc agatgctgtt   60
actaaaactt taacaatcca taagttactg ctctcagaag atgatttaaa gacttgggat   120
acaaacggtc ctaaaggata tgatggaact caatctagtt taaaagattt aactggagtt   180
gtagctgagg aaattccaaa tgtatacttt gaattacaaa agtataattt gactgatggt   240
aaggaaaaag aaaatcttaa agatgatagt aaatggacaa cagttcatgg tggtttgaca   300
actaaagatg gacttaaaat tgaaaccagt actcttaaag gtgtgtatcg tattcgtgag   360
gatagaacaa agactaccta tgttggtcct aatgggcaag tattaacagg ttcaaaagcc   420
gtacctgctc ttgtaactct tccacttgtt aacaataatg gtacagtaat tgatgcacat   480
gttttcccta aaaattcata taataaacca gttgtagata aaagaattgc tgatactttg   540
aattataacg atcaaaatgg tctgtctatc ggtactaaaa tcccatatgt tgttaataca   600
acaattccaa gtaatgcaac atttgcaact tcattttggt cagatgaaat gacagaaggt   660
ctaacttata atgaagatgt aacaattact ttgaataatg tagctatgga tcaagctgat   720
tatgaagtca ctaaaggaaa taatggcttt aacttaaaat taacagaagc aggtttagct   780
aaaattaatg gtaaggatgc agaccaaaaa atccaaatta cttactcagc tactttgaac   840
tcacttgctg ttgcagacat tcctgaaagt aacgatatta catatcatta cggaaatcat   900
caagatcatg ggaatactcc aaaaccaact aaacctaata atggtcaaat tacagtaact   960
aagacatggg acagtcaacc tgctcctgag ggggtgaaag cgactgttca acttgtaaat   1020
gccaagactg gtgagaaagt cggtgctcct gtagaacttt cagaaaataa ttggacatat   1080
acttggagtg gtctagataa ttctattgaa tacaaagttg aagaagaata taatggatac   1140
tcagctgaat acacagtaga gagcaaaggg aagttggggg taaaaaactg gaaagataat   1200
aacccagctc caatcaatcc tgaagaacca cgtgtaaaaa catacggtaa aaagtttgtc   1260
aaagtagacc aaaaagatac tcgtctagaa aatgcgcagt tcgttgttaa aaaagcagat   1320
agcaataaat atattgcctt taagtcaact gcacaacaag ctgcagatga aaaagcagca   1380
gcaactgcaa aacaaaaatt ggatgcagcg gtagcagctt acacaaatgc tgcagataag   1440
caagccgctc aagctctagt agatcaagca cagcaagaat acaatgtagc ttacaaagaa   1500
gccaaatttg gttatgttga agtagctgga aaagatgaag caatggttct tacttctaat   1560
acggatggtc aattccaaat ttcaggtctt gctgctggta cttataaatt agaagaaatt   1620
aaagctccag aaggttttgc gaaaattgat gatgtagaat ttgttgttgg agcaggttct   1680
tggaatcaag gtgagtttaa ttacttaaaa gatgttcaaa agaatgacgc tacaaaagta   1740
gtcaacaaaa aaatcactgg atccggcagc ggtggcggtg gcgctgcaac agtttttgcg   1800
gctgggacga caacaacatc tgttaccgtt cataaactat tggcaacaga tggggatatg   1860
gataaaattg caaatgagtt agaaacaggt aactatgctg gtaataaagt gggtgttcta   1920
cctgcaaatg caaaagaaat tgccggtgtt atgttcgttt ggacaaatac taataatgaa   1980
attattgatg aaaatggcca aactctagga gtgaatattg atccacaaac atttaaactc   2040
tcaggggcaa tgccggcaac tgcaatgaaa aaattaacag aagctgaagg agctaaattt   2100
aacacggcaa atttaccagc tgctaagtat aaaatttatg aaattcacag tttatcaact   2160
tatgtcggtg aagatggagc aaccttaaca ggttctaaag cagttccaat tgaaattgaa   2220
ttaccattga acgatgttgt ggatgcgcat gtgtatccaa aaaatacaga agcaaagcca   2280
aaaattgata aagatttcaa aggtaaagca aatccagata caccacgtgt agataaagat   2340
acacctgtga accaccaagt tggagatgtt gtagagtacg aaattgttac aaaaattcca   2400
gcacttgcta attatgcaac agcaaactgg agcgatagaa tgactgaagg tttggcattc   2460
aacaaaggta cagtgaaagt aactgttgat gatgttgcac ttgaagcagg tgattatgct   2520
ctaacagaag tagcaactgg ttttgatttg aaattaacag atgctggttt agctaaagtg   2580
aatgaccaaa acgctgaaaa aactgtgaaa atcacttatt cggcaacatt gaatgacaaa   2640
gcaattgtag aagtaccaga atctaatgat gtaacattta actatggtaa taatccagat   2700
cacgggaata ctccaaagcc gaataagcca aatgaaaacg gcgatttgac attgaccaag   2760
acatgggttg atgctacagg tgcaccaatt ccggctggag ctgaagcaac gttcgatttg   2820
gttaatgctc agactggtaa agttgtacaa actgtaactt tgacaacaga caaaaataca   2880
gttactgtta acggattgga taaaaataca gaatataaat tcgttgaacg tagtataaaa   2940
gggtattcag cagattatca agaaatcact acagctggag aaattgctgt caagaactgg   3000
aaagacgaaa atccaaaacc acttgatcca acagagccaa aagttgttac atatggtaaa   3060
aagtttgtca aagttaatga taaagataat cgtttagctg gggcagaatt tgtaattgca   3120
aatgctgata atgctggtca atatttagca cgtaaagcag ataaagtgag tcaagaagag   3180
aagcagttgg ttgttacaac aaaggatgct ttagatagag cagttgctgc ttataacgct   3240
cttactgcac aacaacaaac tcagcaagaa aaagagaaag ttgacaaagc tcaagctgct   3300
tataatgctg ctgtgattgc tgccaacaat gcatttgaat gggtggcaga taaggacaat   3360
gaaaatgttg tgaaattagt ttctgatgca caaggtcgct ttgaaattac aggccttctt   3420
gcaggtacat attacttaga agaaacaaaa cagcctgctg gttatgcatt actaactagc   3480
cgtcagaaat ttgaagtcac tgcaacttct tattcagcga ctggacaagg cattgagtat   3540
actgctggtt caggtaaaga tgacgctaca aaagtagtca acaaaaaaat cactctcgag   3600
ggcagcggtg gcggtggcgc ggaacaaaaa actaagacac ttacagttca taaattattg   3660
atgacagatc aagagcttga cgcttggaat tctgatgcga ttactactgc aggttatgac   3720
ggttcgcaaa attttgaaca gttcaaacaa cttcaaggtg ttccacaagg agtaaccgaa   3780
atctctggtg ttgcattcga gttacagagt tatacgggtc ctcaaggaaa agaacaagaa   3840
aatttaacga atgatgcggt ttggactgcg gttaataaag gtgtgacgac tgaaacgggt   3900
gttaaatttg atactgaagt tttacaaggg acatatcgtc ttgtcgaagt acgtaaagaa   3960
tcgacttatg tcggtccaaa tggtaaagtt ttaacaggta tgaaagctgt tcctgcttta   4020
attattctgc cgcttgtaaa ccaaaatggt gttgtagaaa atgcacatgt ctatccaaag   4080
aattctgaag acaaacctac agcaacgaaa acatttgata ctgcagcagg tttcgtagat   4140
ccaggtgaaa aaggtttagc aattggcact aaggtaccgt atattgttac aacaactatt   4200
ccgaaaaact caactcttgc aacagctttc tggtcagatg aaatgacaga aggtctagat   4260
tataatggtg atgtagttgt taattataat ggtcaaccgc ttgataattc tcattacaca   4320
ttagaagcag gtcataatgg ctttatcttg aagttaaatg aaaaaggtct ggaagcaatc   4380
aacggtaaag atgcagaagc aacaattacg ttgaagtata ctgcaacttt aaatgctctt   4440
gctgttgctg atgtgccaga agcgaatgat gtaacattcc attatggaaa caacccaggt   4500
catggtaaca ctccaaaacc aaacaaacct aaaaacggtg aacttacaat tactaaaaca   4560
tgggctgatg ctaaagatgc tcctatagca ggtgtagaag taacttttga tttggtaaat   4620
gctcagacag gtgaggtcgt taaagtacct ggacatgaaa caggtattgt attgaatcaa   4680
acaaataatt ggacatttac tgctacaggt cttgataata atacagaata taaatttgtt   4740
gaacggacaa ttaagggata ttctgcagat taccaaacaa ttactgaaac aggaaaaatt   4800
gctgttaaaa actggaaaga tgaaaatcca gaaccaataa atcctgaaga gccacgtgta   4860
aaaacatatg gtaaaaaatt cgttaaggtt gaccaaaaag acgaacgctt aaaagaagca   4920
caattcgttg tgaagaatga gcaagggaaa tatcttgcac tcaaatctgc agcacaacaa   4980
gctgtaaatg agaaagctgc cgcagaagcg aaacaagcgc tagatgcagc gatagcagcc   5040
tatacaaatg ctgcagataa aaatgcagca caagctgtag tagatgctgc gcaaaaaaca   5100
tataatgaca attacagagc agctagattt ggctatgtag aagtagagag aaaagaagat   5160
gcgttagttc ttacttctaa cactgatggt caattccaaa tttcaggtct tgctgctgga   5220
agctacacgt tggaagaaac aaaagctcca gaaggctttg caaaacttgg agatgtgaag   5280
tttgaggttg gagcaggttc ttggaatcaa ggtgatttca attatttaaa agatgttcag   5340
aagaacgacg ctacaaaagt agtcaacaaa aaaatcacgc tcgagcacca ccaccaccac   5400
cac                                                                 5403

<210>   258
<211>   1312
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length spr0057 as found in the R6 strain

<400>   258
Met Lys His Glu Lys Gln Gln Arg Phe Ser Ile Arg Lys Tyr Ala Val 
1               5                   10                  15      

Gly Ala Ala Ser Val Leu Ile Gly Phe Ala Phe Gln Ala Gln Thr Val 
            20                  25                  30          

Ala Ala Asp Gly Val Thr Pro Thr Thr Thr Glu Asn Gln Pro Thr Ile 
        35                  40                  45              

His Thr Val Ser Asp Ser Pro Gln Ser Ser Glu Asn Arg Thr Glu Glu 
    50                  55                  60                  

Thr Pro Lys Ala Glu Leu Gln Pro Glu Ala Pro Lys Thr Val Glu Thr 
65                  70                  75                  80  

Glu Thr Pro Ala Thr Asp Lys Val Ala Ser Leu Pro Lys Thr Glu Glu 
                85                  90                  95      

Lys Pro Gln Glu Glu Val Ser Ser Thr Pro Ser Asp Lys Ala Glu Val 
            100                 105                 110         

Val Thr Pro Thr Ser Ala Glu Lys Glu Thr Ala Asn Lys Lys Glu Glu 
        115                 120                 125             

Glu Ala Ser Pro Lys Lys Glu Glu Ala Lys Glu Val Asp Ser Lys Glu 
    130                 135                 140                 

Ser Asn Thr Asp Lys Thr Asp Lys Asp Lys Pro Ala Lys Lys Asp Glu 
145                 150                 155                 160 

Ala Lys Ala Glu Ala Asp Lys Pro Glu Thr Glu Thr Gly Lys Glu Arg 
                165                 170                 175     

Ala Ala Thr Val Asn Glu Lys Leu Ala Lys Lys Lys Ile Val Ser Ile 
            180                 185                 190         

Asp Ala Gly Arg Lys Tyr Phe Ser Pro Glu Gln Leu Lys Glu Ile Ile 
        195                 200                 205             

Asp Lys Ala Lys His Tyr Gly Tyr Thr Asp Leu His Leu Leu Val Gly 
    210                 215                 220                 

Asn Asp Gly Leu Arg Phe Met Leu Asp Asp Met Ser Ile Thr Ala Asn 
225                 230                 235                 240 

Gly Lys Thr Tyr Ala Ser Asp Asp Val Lys Arg Ala Ile Glu Lys Gly 
                245                 250                 255     

Thr Asn Asp Tyr Tyr Asn Asp Pro Asn Gly Asn His Leu Thr Glu Ser 
            260                 265                 270         

Gln Met Thr Asp Leu Ile Asn Tyr Ala Lys Asp Lys Gly Ile Gly Leu 
        275                 280                 285             

Ile Pro Thr Val Asn Ser Pro Gly His Met Asp Ala Ile Leu Asn Ala 
    290                 295                 300                 

Met Lys Glu Leu Gly Ile Gln Asn Pro Asn Phe Ser Tyr Phe Gly Lys 
305                 310                 315                 320 

Lys Ser Ala Arg Thr Val Asp Leu Asp Asn Glu Gln Ala Val Ala Phe 
                325                 330                 335     

Thr Lys Ala Leu Ile Asp Lys Tyr Ala Ala Tyr Phe Ala Lys Lys Thr 
            340                 345                 350         

Glu Ile Phe Asn Ile Gly Leu Asp Glu Tyr Ala Asn Asp Ala Thr Asp 
        355                 360                 365             

Ala Lys Gly Trp Ser Val Leu Gln Ala Asp Lys Tyr Tyr Pro Asn Glu 
    370                 375                 380                 

Gly Tyr Pro Val Lys Gly Tyr Glu Lys Phe Ile Ala Tyr Ala Asn Asp 
385                 390                 395                 400 

Leu Ala Arg Ile Val Lys Ser His Gly Leu Lys Pro Met Ala Phe Asn 
                405                 410                 415     

Asp Gly Ile Tyr Tyr Asn Ser Asp Thr Ser Phe Gly Ser Phe Asp Lys 
            420                 425                 430         

Asp Ile Ile Val Ser Met Trp Thr Gly Gly Trp Gly Gly Tyr Asp Val 
        435                 440                 445             

Ala Ser Ser Lys Leu Leu Ala Glu Lys Gly His Gln Ile Leu Asn Thr 
    450                 455                 460                 

Asn Asp Ala Trp Cys Tyr Val Leu Gly Arg Asn Ala Asp Gly Gln Gly 
465                 470                 475                 480 

Trp Tyr Asn Leu Asp Gln Gly Leu Asn Gly Ile Lys Asn Thr Pro Ile 
                485                 490                 495     

Thr Ser Val Pro Lys Thr Glu Gly Ala Asp Ile Pro Ile Ile Gly Gly 
            500                 505                 510         

Met Val Ala Ala Trp Ala Asp Thr Pro Ser Ala Arg Tyr Ser Pro Ser 
        515                 520                 525             

His Leu Phe Lys Leu Met Arg His Phe Ala Asn Ala Asn Ala Glu Tyr 
    530                 535                 540                 

Phe Ala Ala Asp Tyr Glu Ser Ala Glu Gln Ala Leu Asn Glu Val Pro 
545                 550                 555                 560 

Lys Asp Leu Asn Arg Tyr Thr Ala Glu Ser Val Ala Ala Val Lys Glu 
                565                 570                 575     

Ala Glu Lys Ala Ile Arg Ser Leu Asp Ser Asn Leu Ser Arg Ala Gln 
            580                 585                 590         

Gln Asp Thr Ile Asp Gln Ala Ile Ala Lys Leu Gln Glu Thr Val Asn 
        595                 600                 605             

Asn Leu Thr Leu Thr Pro Glu Ala Gln Lys Glu Glu Glu Ala Lys Arg 
    610                 615                 620                 

Glu Val Glu Lys Leu Ala Lys Asn Lys Val Ile Ser Ile Asp Ala Gly 
625                 630                 635                 640 

Arg Lys Tyr Phe Thr Leu Asp Gln Leu Lys Arg Ile Val Asp Lys Ala 
                645                 650                 655     

Ser Glu Leu Gly Tyr Ser Asp Val His Leu Leu Leu Gly Asn Asp Gly 
            660                 665                 670         

Leu Arg Phe Leu Leu Asn Asp Met Thr Ile Thr Ala Asn Gly Lys Thr 
        675                 680                 685             

Tyr Ala Ser Asp Asp Val Lys Lys Ala Ile Ile Glu Gly Thr Lys Ala 
    690                 695                 700                 

Tyr Tyr Asp Asp Pro Asn Gly Thr Ala Leu Thr Gln Ala Glu Val Thr 
705                 710                 715                 720 

Glu Leu Ile Glu Tyr Ala Lys Ser Lys Asp Ile Gly Leu Ile Pro Ala 
                725                 730                 735     

Ile Asn Ser Pro Gly His Met Asp Ala Met Leu Val Ala Met Glu Lys 
            740                 745                 750         

Leu Gly Ile Lys Asn Pro Gln Ala His Phe Asp Lys Val Ser Lys Thr 
        755                 760                 765             

Thr Met Asp Leu Lys Asn Glu Glu Ala Met Asn Phe Val Lys Ala Leu 
    770                 775                 780                 

Ile Gly Lys Tyr Met Asp Phe Phe Ala Gly Lys Thr Lys Ile Phe Asn 
785                 790                 795                 800 

Phe Gly Thr Asp Glu Tyr Ala Asn Asp Ala Thr Ser Ala Gln Gly Trp 
                805                 810                 815     

Tyr Tyr Leu Lys Trp Tyr Gln Leu Tyr Gly Lys Phe Ala Glu Tyr Ala 
            820                 825                 830         

Asn Thr Leu Ala Ala Met Ala Lys Glu Arg Gly Leu Gln Pro Met Ala 
        835                 840                 845             

Phe Asn Asp Gly Phe Tyr Tyr Glu Asp Lys Asp Asp Val Gln Phe Asp 
    850                 855                 860                 

Lys Asp Val Leu Ile Ser Tyr Trp Ser Lys Gly Trp Trp Gly Tyr Asn 
865                 870                 875                 880 

Leu Ala Ser Pro Gln Tyr Leu Ala Ser Lys Gly Tyr Lys Phe Leu Asn 
                885                 890                 895     

Thr Asn Gly Asp Trp Tyr Tyr Val Ile Gly Asn His Lys Gln Asp Glu 
            900                 905                 910         

Ala Tyr Pro Leu Ser Lys Ala Val Glu Asn Ser Gly Lys Val Pro Phe 
        915                 920                 925             

Asn Gln Leu Ala Ser Thr Lys Tyr Pro Glu Val Asp Leu Pro Thr Val 
    930                 935                 940                 

Gly Ser Met Leu Ser Ile Trp Ala Asp Arg Pro Ser Ala Glu Tyr Lys 
945                 950                 955                 960 

Glu Glu Glu Ile Phe Glu Leu Met Thr Ala Phe Ala Asp His Asn Lys 
                965                 970                 975     

Asp Tyr Phe Arg Ala Asn Tyr Asn Ala Leu Arg Glu Glu Leu Ala Lys 
            980                 985                 990         

Ile Pro Thr Asn Leu Glu Gly Tyr Ser Lys Glu Ser Leu Glu Ala Leu 
        995                 1000                1005            

Asp Ala Ala Lys Thr Ala Leu Asn Tyr Asn Leu Asn Arg Asn Lys Gln 
    1010                1015                1020                

Ala Glu Leu Asp Thr Leu Val Ala Asn Leu Lys Ala Ala Leu Gln Gly 
1025                1030                1035                1040

Leu Lys Pro Ala Ala Thr His Ser Gly Ser Leu Asp Glu Asn Glu Val 
                1045                1050                1055    

Ala Ala Asn Val Glu Thr Arg Pro Glu Leu Ile Thr Arg Thr Glu Glu 
            1060                1065                1070        

Ile Pro Phe Glu Val Ile Lys Lys Glu Asn Pro Asn Leu Pro Ala Gly 
        1075                1080                1085            

Gln Glu Asn Ile Ile Thr Ala Gly Val Lys Gly Glu Arg Thr His Tyr 
    1090                1095                1100                

Ile Ser Val Leu Thr Glu Asn Gly Lys Thr Thr Glu Thr Val Leu Asp 
1105                1110                1115                1120

Ser Gln Val Thr Lys Glu Val Ile Asn Gln Val Val Glu Val Gly Ser 
                1125                1130                1135    

Pro Val Thr His Lys Gly Asp Glu Ser Gly Leu Ala Pro Thr Thr Glu 
            1140                1145                1150        

Val Lys Pro Arg Leu Asp Ile Gln Glu Glu Glu Ile Pro Phe Thr Thr 
        1155                1160                1165            

Val Thr Arg Glu Asn Pro Leu Leu Leu Lys Gly Lys Thr Gln Val Ile 
    1170                1175                1180                

Thr Lys Gly Val Asn Gly His Arg Ser Asn Phe Tyr Ser Val Ser Thr 
1185                1190                1195                1200

Ser Ala Asp Gly Lys Glu Val Lys Thr Leu Val Asn Ser Val Val Ala 
                1205                1210                1215    

Gln Glu Ala Val Thr Gln Ile Val Glu Val Gly Thr Met Val Thr His 
            1220                1225                1230        

Val Gly Asp Glu Asn Gly Gln Ala Ala Ile Ala Glu Glu Lys Pro Lys 
        1235                1240                1245            

Leu Glu Ile Pro Ser Gln Pro Ala Pro Ser Thr Ala Pro Ala Glu Glu 
    1250                1255                1260                

Ser Lys Ala Leu Pro Gln Asp Pro Ala Pro Val Val Thr Glu Lys Lys 
1265                1270                1275                1280

Leu Pro Glu Thr Gly Thr His Asp Ser Ala Glu Leu Val Val Ala Gly 
                1285                1290                1295    

Leu Met Ser Thr Leu Ala Ala Tyr Gly Leu Thr Lys Arg Lys Glu Asp 
            1300                1305                1310        


<210>   259
<211>   1062
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   spr0057 with N-terminal and C-terminal truncations

<400>   259
Leu His Leu Leu Val Gly Asn Asp Gly Leu Arg Phe Met Leu Asp Asp 
1               5                   10                  15      

Met Ser Ile Thr Ala Asn Gly Lys Thr Tyr Ala Ser Asp Asp Val Lys 
            20                  25                  30          

Arg Ala Ile Glu Lys Gly Thr Asn Asp Tyr Tyr Asn Asp Pro Asn Gly 
        35                  40                  45              

Asn His Leu Thr Glu Ser Gln Met Thr Asp Leu Ile Asn Tyr Ala Lys 
    50                  55                  60                  

Asp Lys Gly Ile Gly Leu Ile Pro Thr Val Asn Ser Pro Gly His Met 
65                  70                  75                  80  

Asp Ala Ile Leu Asn Ala Met Lys Glu Leu Gly Ile Gln Asn Pro Asn 
                85                  90                  95      

Phe Ser Tyr Phe Gly Lys Lys Ser Ala Arg Thr Val Asp Leu Asp Asn 
            100                 105                 110         

Glu Gln Ala Val Ala Phe Thr Lys Ala Leu Ile Asp Lys Tyr Ala Ala 
        115                 120                 125             

Tyr Phe Ala Lys Lys Thr Glu Ile Phe Asn Ile Gly Leu Asp Glu Tyr 
    130                 135                 140                 

Ala Asn Asp Ala Thr Asp Ala Lys Gly Trp Ser Val Leu Gln Ala Asp 
145                 150                 155                 160 

Lys Tyr Tyr Pro Asn Glu Gly Tyr Pro Val Lys Gly Tyr Glu Lys Phe 
                165                 170                 175     

Ile Ala Tyr Ala Asn Asp Leu Ala Arg Ile Val Lys Ser His Gly Leu 
            180                 185                 190         

Lys Pro Met Ala Phe Asn Asp Gly Ile Tyr Tyr Asn Ser Asp Thr Ser 
        195                 200                 205             

Phe Gly Ser Phe Asp Lys Asp Ile Ile Val Ser Met Trp Thr Gly Gly 
    210                 215                 220                 

Trp Gly Gly Tyr Asp Val Ala Ser Ser Lys Leu Leu Ala Glu Lys Gly 
225                 230                 235                 240 

His Gln Ile Leu Asn Thr Asn Asp Ala Trp Cys Tyr Val Leu Gly Arg 
                245                 250                 255     

Asn Ala Asp Gly Gln Gly Trp Tyr Asn Leu Asp Gln Gly Leu Asn Gly 
            260                 265                 270         

Ile Lys Asn Thr Pro Ile Thr Ser Val Pro Lys Thr Glu Gly Ala Asp 
        275                 280                 285             

Ile Pro Ile Ile Gly Gly Met Val Ala Ala Trp Ala Asp Thr Pro Ser 
    290                 295                 300                 

Ala Arg Tyr Ser Pro Ser His Leu Phe Lys Leu Met Arg His Phe Ala 
305                 310                 315                 320 

Asn Ala Asn Ala Glu Tyr Phe Ala Ala Asp Tyr Glu Ser Ala Glu Gln 
                325                 330                 335     

Ala Leu Asn Glu Val Pro Lys Asp Leu Asn Arg Tyr Thr Ala Glu Ser 
            340                 345                 350         

Val Ala Ala Val Lys Glu Ala Glu Lys Ala Ile Arg Ser Leu Asp Ser 
        355                 360                 365             

Asn Leu Ser Arg Ala Gln Gln Asp Thr Ile Asp Gln Ala Ile Ala Lys 
    370                 375                 380                 

Leu Gln Glu Thr Val Asn Asn Leu Thr Leu Thr Pro Glu Ala Gln Lys 
385                 390                 395                 400 

Glu Glu Glu Ala Lys Arg Glu Val Glu Lys Leu Ala Lys Asn Lys Val 
                405                 410                 415     

Ile Ser Ile Asp Ala Gly Arg Lys Tyr Phe Thr Leu Asp Gln Leu Lys 
            420                 425                 430         

Arg Ile Val Asp Lys Ala Ser Glu Leu Gly Tyr Ser Asp Val His Leu 
        435                 440                 445             

Leu Leu Gly Asn Asp Gly Leu Arg Phe Leu Leu Asn Asp Met Thr Ile 
    450                 455                 460                 

Thr Ala Asn Gly Lys Thr Tyr Ala Ser Asp Asp Val Lys Lys Ala Ile 
465                 470                 475                 480 

Ile Glu Gly Thr Lys Ala Tyr Tyr Asp Asp Pro Asn Gly Thr Ala Leu 
                485                 490                 495     

Thr Gln Ala Glu Val Thr Glu Leu Ile Glu Tyr Ala Lys Ser Lys Asp 
            500                 505                 510         

Ile Gly Leu Ile Pro Ala Ile Asn Ser Pro Gly His Met Asp Ala Met 
        515                 520                 525             

Leu Val Ala Met Glu Lys Leu Gly Ile Lys Asn Pro Gln Ala His Phe 
    530                 535                 540                 

Asp Lys Val Ser Lys Thr Thr Met Asp Leu Lys Asn Glu Glu Ala Met 
545                 550                 555                 560 

Asn Phe Val Lys Ala Leu Ile Gly Lys Tyr Met Asp Phe Phe Ala Gly 
                565                 570                 575     

Lys Thr Lys Ile Phe Asn Phe Gly Thr Asp Glu Tyr Ala Asn Asp Ala 
            580                 585                 590         

Thr Ser Ala Gln Gly Trp Tyr Tyr Leu Lys Trp Tyr Gln Leu Tyr Gly 
        595                 600                 605             

Lys Phe Ala Glu Tyr Ala Asn Thr Leu Ala Ala Met Ala Lys Glu Arg 
    610                 615                 620                 

Gly Leu Gln Pro Met Ala Phe Asn Asp Gly Phe Tyr Tyr Glu Asp Lys 
625                 630                 635                 640 

Asp Asp Val Gln Phe Asp Lys Asp Val Leu Ile Ser Tyr Trp Ser Lys 
                645                 650                 655     

Gly Trp Trp Gly Tyr Asn Leu Ala Ser Pro Gln Tyr Leu Ala Ser Lys 
            660                 665                 670         

Gly Tyr Lys Phe Leu Asn Thr Asn Gly Asp Trp Tyr Tyr Val Ile Gly 
        675                 680                 685             

Asn His Lys Gln Asp Glu Ala Tyr Pro Leu Ser Lys Ala Val Glu Asn 
    690                 695                 700                 

Ser Gly Lys Val Pro Phe Asn Gln Leu Ala Ser Thr Lys Tyr Pro Glu 
705                 710                 715                 720 

Val Asp Leu Pro Thr Val Gly Ser Met Leu Ser Ile Trp Ala Asp Arg 
                725                 730                 735     

Pro Ser Ala Glu Tyr Lys Glu Glu Glu Ile Phe Glu Leu Met Thr Ala 
            740                 745                 750         

Phe Ala Asp His Asn Lys Asp Tyr Phe Arg Ala Asn Tyr Asn Ala Leu 
        755                 760                 765             

Arg Glu Glu Leu Ala Lys Ile Pro Thr Asn Leu Glu Gly Tyr Ser Lys 
    770                 775                 780                 

Glu Ser Leu Glu Ala Leu Asp Ala Ala Lys Thr Ala Leu Asn Tyr Asn 
785                 790                 795                 800 

Leu Asn Arg Asn Lys Gln Ala Glu Leu Asp Thr Leu Val Ala Asn Leu 
                805                 810                 815     

Lys Ala Ala Leu Gln Gly Leu Lys Pro Ala Ala Thr His Ser Gly Ser 
            820                 825                 830         

Leu Asp Glu Asn Glu Val Ala Ala Asn Val Glu Thr Arg Pro Glu Leu 
        835                 840                 845             

Ile Thr Arg Thr Glu Glu Ile Pro Phe Glu Val Ile Lys Lys Glu Asn 
    850                 855                 860                 

Pro Asn Leu Pro Ala Gly Gln Glu Asn Ile Ile Thr Ala Gly Val Lys 
865                 870                 875                 880 

Gly Glu Arg Thr His Tyr Ile Ser Val Leu Thr Glu Asn Gly Lys Thr 
                885                 890                 895     

Thr Glu Thr Val Leu Asp Ser Gln Val Thr Lys Glu Val Ile Asn Gln 
            900                 905                 910         

Val Val Glu Val Gly Ser Pro Val Thr His Lys Gly Asp Glu Ser Gly 
        915                 920                 925             

Leu Ala Pro Thr Thr Glu Val Lys Pro Arg Leu Asp Ile Gln Glu Glu 
    930                 935                 940                 

Glu Ile Pro Phe Thr Thr Val Thr Arg Glu Asn Pro Leu Leu Leu Lys 
945                 950                 955                 960 

Gly Lys Thr Gln Val Ile Thr Lys Gly Val Asn Gly His Arg Ser Asn 
                965                 970                 975     

Phe Tyr Ser Val Ser Thr Ser Ala Asp Gly Lys Glu Val Lys Thr Leu 
            980                 985                 990         

Val Asn Ser Val Val Ala Gln Glu Ala Val Thr Gln Ile Val Glu Val 
        995                 1000                1005            

Gly Thr Met Val Thr His Val Gly Asp Glu Asn Gly Gln Ala Ala Ile 
    1010                1015                1020                

Ala Glu Glu Lys Pro Lys Leu Glu Ile Pro Ser Gln Pro Ala Pro Ser 
1025                1030                1035                1040

Thr Ala Pro Ala Glu Glu Ser Lys Ala Leu Pro Gln Asp Pro Ala Pro 
                1045                1050                1055    

Val Val Thr Glu Lys Lys 
            1060        

<210>   260
<211>   2228
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length spr0565 as found in the R6 strain

<400>   260
Met Gly Lys Gly His Trp Asn Arg Lys Arg Val Tyr Ser Ile Arg Lys 
1               5                   10                  15      

Phe Ala Val Gly Ala Cys Ser Val Met Ile Gly Thr Cys Ala Val Leu 
            20                  25                  30          

Leu Gly Gly Asn Ile Ala Gly Glu Ser Val Val Tyr Ala Asp Glu Thr 
        35                  40                  45              

Leu Ile Thr His Thr Ala Glu Lys Pro Lys Glu Glu Lys Met Ile Val 
    50                  55                  60                  

Glu Glu Lys Ala Asp Lys Ala Leu Glu Thr Lys Asn Val Val Glu Arg 
65                  70                  75                  80  

Thr Glu Gln Ser Glu Pro Ser Ser Thr Glu Ala Ile Ala Ser Glu Lys 
                85                  90                  95      

Lys Glu Asp Glu Ala Val Thr Pro Lys Glu Glu Lys Val Ser Ala Lys 
            100                 105                 110         

Pro Glu Glu Lys Ala Pro Arg Ile Glu Ser Gln Ala Ser Ser Gln Glu 
        115                 120                 125             

Lys Pro Leu Lys Glu Asp Ala Lys Ala Val Thr Asn Glu Glu Val Asn 
    130                 135                 140                 

Gln Met Ile Glu Asn Arg Lys Val Asp Phe Asn Gln Asn Trp Tyr Phe 
145                 150                 155                 160 

Lys Leu Asn Ala Asn Ser Lys Glu Ala Ile Lys Pro Asp Ala Asp Val 
                165                 170                 175     

Ser Thr Trp Lys Lys Leu Asp Leu Pro Tyr Asp Trp Ser Ile Phe Asn 
            180                 185                 190         

Asp Phe Asp His Glu Ser Pro Ala Gln Asn Glu Gly Gly Gln Leu Asn 
        195                 200                 205             

Gly Gly Glu Ala Trp Tyr Arg Lys Thr Phe Lys Leu Asp Glu Lys Asp 
    210                 215                 220                 

Leu Lys Lys Asn Val Arg Leu Thr Phe Asp Gly Val Tyr Met Asp Ser 
225                 230                 235                 240 

Gln Val Tyr Val Asn Gly Gln Leu Val Gly His Tyr Pro Asn Gly Tyr 
                245                 250                 255     

Asn Gln Phe Ser Tyr Asp Ile Thr Lys Tyr Leu Tyr Lys Asp Gly Arg 
            260                 265                 270         

Glu Asn Val Ile Ala Val His Ala Val Asn Lys Gln Pro Ser Ser Arg 
        275                 280                 285             

Trp Tyr Ser Gly Ser Gly Ile Tyr Arg Asp Val Thr Leu Gln Val Thr 
    290                 295                 300                 

Asp Lys Val His Val Glu Lys Asn Gly Thr Thr Ile Leu Thr Pro Lys 
305                 310                 315                 320 

Leu Glu Glu Gln Gln His Gly Lys Val Glu Thr His Val Thr Ser Lys 
                325                 330                 335     

Ile Val Asn Thr Asp Asp Lys Asp His Glu Leu Val Ala Glu Tyr Gln 
            340                 345                 350         

Ile Val Glu Arg Gly Gly His Ala Val Thr Gly Leu Val Arg Thr Ala 
        355                 360                 365             

Ser Arg Thr Leu Lys Ala His Glu Ser Thr Ser Leu Asp Ala Ile Leu 
    370                 375                 380                 

Glu Val Glu Arg Pro Lys Leu Trp Thr Val Leu Asn Asp Lys Pro Ala 
385                 390                 395                 400 

Leu Tyr Glu Leu Ile Thr Arg Val Tyr Arg Asp Gly Gln Leu Val Asp 
                405                 410                 415     

Ala Lys Lys Asp Leu Phe Gly Tyr Arg Tyr Tyr His Trp Thr Pro Asn 
            420                 425                 430         

Glu Gly Phe Ser Leu Asn Gly Glu Arg Ile Lys Phe His Gly Val Ser 
        435                 440                 445             

Leu His His Asp His Gly Ala Leu Gly Ala Glu Glu Asn Tyr Lys Ala 
    450                 455                 460                 

Glu Tyr Arg Arg Leu Lys Gln Met Lys Glu Met Gly Val Asn Ser Ile 
465                 470                 475                 480 

Arg Thr Thr His Asn Pro Ala Ser Glu Gln Thr Leu Gln Ile Ala Ala 
                485                 490                 495     

Glu Leu Gly Leu Leu Val Gln Glu Glu Ala Phe Asp Thr Trp Tyr Gly 
            500                 505                 510         

Gly Lys Lys Pro Tyr Asp Tyr Gly Arg Phe Phe Glu Lys Asp Ala Thr 
        515                 520                 525             

His Pro Glu Ala Arg Lys Gly Glu Lys Trp Ser Asp Phe Asp Leu Arg 
    530                 535                 540                 

Thr Met Val Glu Arg Gly Lys Asn Asn Pro Ala Ile Phe Met Trp Ser 
545                 550                 555                 560 

Ile Gly Asn Glu Ile Gly Glu Ala Asn Gly Asp Ala His Ser Leu Ala 
                565                 570                 575     

Thr Val Lys Arg Leu Val Lys Val Ile Lys Asp Val Asp Lys Thr Arg 
            580                 585                 590         

Tyr Val Thr Met Gly Ala Asp Lys Phe Arg Phe Gly Asn Gly Ser Gly 
        595                 600                 605             

Gly His Glu Lys Ile Ala Asp Glu Leu Asp Ala Val Gly Phe Asn Tyr 
    610                 615                 620                 

Ser Glu Asp Asn Tyr Lys Ala Leu Arg Ala Lys His Pro Lys Trp Leu 
625                 630                 635                 640 

Ile Tyr Gly Ser Glu Thr Ser Ser Ala Thr Arg Thr Arg Gly Ser Tyr 
                645                 650                 655     

Tyr Arg Pro Glu Arg Glu Leu Lys His Ser Asn Gly Pro Glu Arg Asn 
            660                 665                 670         

Tyr Glu Gln Ser Asp Tyr Gly Asn Asp Arg Val Gly Trp Gly Lys Thr 
        675                 680                 685             

Ala Thr Ala Ser Trp Thr Phe Asp Arg Asp Asn Ala Gly Tyr Ala Gly 
    690                 695                 700                 

Gln Phe Ile Trp Thr Gly Thr Asp Tyr Ile Gly Glu Pro Thr Pro Trp 
705                 710                 715                 720 

His Asn Gln Asn Gln Thr Pro Val Lys Ser Ser Tyr Phe Gly Ile Val 
                725                 730                 735     

Asp Thr Ala Gly Ile Pro Lys His Asp Phe Tyr Leu Tyr Gln Ser Gln 
            740                 745                 750         

Trp Val Ser Val Lys Lys Lys Pro Met Val His Leu Leu Pro His Trp 
        755                 760                 765             

Asn Trp Glu Asn Lys Glu Leu Ala Ser Lys Val Ala Asp Ser Glu Gly 
    770                 775                 780                 

Lys Ile Pro Val Arg Ala Tyr Ser Asn Ala Ser Ser Val Glu Leu Phe 
785                 790                 795                 800 

Leu Asn Gly Lys Ser Leu Gly Leu Lys Thr Phe Asn Lys Lys Gln Thr 
                805                 810                 815     

Ser Asp Gly Arg Thr Tyr Gln Glu Gly Ala Asn Ala Asn Glu Leu Tyr 
            820                 825                 830         

Leu Glu Trp Lys Val Ala Tyr Gln Pro Gly Thr Leu Glu Ala Ile Ala 
        835                 840                 845             

Arg Asp Glu Ser Gly Lys Glu Ile Ala Arg Asp Lys Ile Thr Thr Ala 
    850                 855                 860                 

Gly Lys Pro Ala Ala Val Arg Leu Ile Lys Glu Asp His Ala Ile Ala 
865                 870                 875                 880 

Ala Asp Gly Lys Asp Leu Thr Tyr Ile Tyr Tyr Glu Ile Val Asp Ser 
                885                 890                 895     

Gln Gly Asn Val Val Pro Thr Ala Asn Asn Leu Val Arg Phe Gln Leu 
            900                 905                 910         

His Gly Gln Gly Gln Leu Val Gly Val Asp Asn Gly Glu Gln Ala Ser 
        915                 920                 925             

Arg Glu Arg Tyr Lys Ala Gln Ala Asp Gly Ser Trp Ile Arg Lys Ala 
    930                 935                 940                 

Phe Asn Gly Lys Gly Val Ala Ile Val Lys Ser Thr Glu Gln Ala Gly 
945                 950                 955                 960 

Lys Phe Thr Leu Thr Ala His Ser Asp Leu Leu Lys Ser Asn Gln Val 
                965                 970                 975     

Thr Val Phe Thr Gly Lys Lys Glu Gly Gln Glu Lys Thr Val Leu Gly 
            980                 985                 990         

Thr Glu Val Pro Lys Val Gln Thr Ile Ile Gly Glu Ala Pro Glu Met 
        995                 1000                1005            

Pro Thr Thr Val Pro Phe Val Tyr Ser Asp Gly Ser Arg Ala Glu Arg 
    1010                1015                1020                

Pro Val Thr Trp Ser Leu Val Asp Val Ser Lys Pro Gly Ile Val Thr 
1025                1030                1035                1040

Val Lys Gly Met Ala Asp Gly Arg Glu Val Glu Ala Arg Val Glu Val 
                1045                1050                1055    

Ile Ala Leu Lys Ser Glu Leu Pro Val Val Lys Arg Ile Ala Pro Asn 
            1060                1065                1070        

Thr Asn Leu Asn Ser Val Asp Lys Ser Val Ser Tyr Val Leu Thr Asp 
        1075                1080                1085            

Gly Ser Val Gln Glu Tyr Glu Val Asp Lys Trp Glu Ile Ala Glu Glu 
    1090                1095                1100                

Asp Lys Ala Lys Leu Ala Ile Pro Gly Ser Arg Ile Gln Ala Thr Gly 
1105                1110                1115                1120

Tyr Leu Glu Gly Gln Pro Ile His Ala Thr Leu Val Val Glu Glu Gly 
                1125                1130                1135    

Asn Pro Ala Ala Pro Val Val Pro Thr Val Thr Val Gly Gly Glu Ala 
            1140                1145                1150        

Val Thr Gly Leu Thr Ser Arg Gln Pro Met Gln Tyr Arg Thr Leu Ser 
        1155                1160                1165            

Tyr Gly Ala Gln Leu Pro Glu Val Thr Ala Ser Ala Glu Asn Ala Asp 
    1170                1175                1180                

Val Thr Val Leu Gln Ala Ser Ala Ala Asn Gly Met Arg Ala Ser Ile 
1185                1190                1195                1200

Phe Ile Gln Pro Lys Asp Gly Gly Pro Leu Gln Thr Tyr Ala Ile Gln 
                1205                1210                1215    

Phe Leu Glu Glu Ala Pro Lys Ile Ala His Leu Ser Leu Gln Val Glu 
            1220                1225                1230        

Lys Ala Asp Ser Leu Lys Glu Asp Gln Thr Val Lys Leu Ser Val Arg 
        1235                1240                1245            

Ala His Tyr Gln Asp Gly Thr Gln Ala Val Leu Pro Ala Asp Lys Val 
    1250                1255                1260                

Thr Phe Ser Thr Ser Gly Glu Gly Glu Val Ala Ile Arg Lys Gly Met 
1265                1270                1275                1280

Leu Glu Leu His Lys Pro Gly Ala Val Thr Leu Asn Ala Glu Tyr Glu 
                1285                1290                1295    

Gly Ala Lys Gly Gln Val Glu Leu Thr Ile Gln Ala Asn Thr Glu Lys 
            1300                1305                1310        

Lys Ile Ala Gln Ser Ile Arg Pro Val Asn Val Val Thr Asp Leu His 
        1315                1320                1325            

Gln Glu Pro Ser Leu Pro Ala Thr Val Thr Val Glu Tyr Asp Lys Gly 
    1330                1335                1340                

Phe Pro Lys Thr His Lys Val Thr Trp Gln Ala Ile Pro Lys Glu Lys 
1345                1350                1355                1360

Leu Asp Ser Tyr Gln Ile Phe Glu Val Leu Gly Lys Val Glu Gly Ile 
                1365                1370                1375    

Asp Leu Glu Ala Arg Ala Lys Val Ser Val Glu Gly Ile Val Ser Val 
            1380                1385                1390        

Glu Glu Val Ser Val Thr Thr Pro Ile Ala Glu Ala Pro Gln Leu Pro 
        1395                1400                1405            

Glu Ser Val Arg Thr Tyr Asp Ser Asn Gly His Val Ser Ser Ala Lys 
    1410                1415                1420                

Val Ala Trp Asp Ala Ile Arg Pro Glu Gln Tyr Ala Lys Glu Gly Val 
1425                1430                1435                1440

Phe Thr Val Asn Gly Arg Leu Glu Gly Thr Gln Leu Thr Thr Lys Leu 
                1445                1450                1455    

His Val Arg Val Ser Ala Gln Thr Glu Gln Gly Ala Asn Ile Ser Asp 
            1460                1465                1470        

Gln Trp Thr Gly Ser Glu Leu Pro Leu Ala Phe Ala Ser Asp Ser Asn 
        1475                1480                1485            

Pro Ser Asp Pro Val Ser Asn Val Asn Asp Lys Leu Ile Ser Tyr Asn 
    1490                1495                1500                

Asn Gln Pro Ala Asn Arg Trp Thr Asn Trp Asn Arg Ser Asn Pro Glu 
1505                1510                1515                1520

Ala Ser Val Gly Val Leu Phe Gly Asp Ser Gly Ile Leu Ser Lys Arg 
                1525                1530                1535    

Ser Val Asp Asn Leu Ser Val Gly Phe His Glu Asp His Gly Val Gly 
            1540                1545                1550        

Ala Pro Lys Ser Tyr Val Ile Glu Tyr Tyr Val Gly Lys Thr Val Pro 
        1555                1560                1565            

Thr Ala Pro Lys Asn Pro Ser Phe Val Gly Asn Glu Asp His Val Phe 
    1570                1575                1580                

Asn Asp Ser Ala Asn Trp Lys Pro Val Thr Asn Leu Lys Ala Pro Ala 
1585                1590                1595                1600

Gln Leu Lys Ala Gly Glu Met Asn His Phe Ser Phe Asp Lys Val Glu 
                1605                1610                1615    

Thr Tyr Ala Ile Arg Ile Arg Met Val Lys Ala Asp Asn Lys Arg Gly 
            1620                1625                1630        

Thr Ser Ile Thr Glu Val Gln Ile Phe Ala Lys Gln Val Ala Ala Ala 
        1635                1640                1645            

Lys Gln Gly Gln Thr Arg Ile Gln Val Asp Gly Lys Asp Leu Ala Asn 
    1650                1655                1660                

Phe Asn Pro Asp Leu Thr Asp Tyr Tyr Leu Glu Ser Val Asp Gly Lys 
1665                1670                1675                1680

Val Pro Ala Val Thr Ala Asn Val Ser Asn Asn Gly Leu Ala Thr Val 
                1685                1690                1695    

Val Pro Ser Val Arg Glu Gly Glu Pro Val Arg Val Ile Ala Lys Ala 
            1700                1705                1710        

Glu Asn Gly Asp Ile Leu Gly Glu Tyr Arg Leu His Phe Thr Lys Asp 
        1715                1720                1725            

Lys Asn Leu Leu Ser His Lys Pro Val Ala Ala Val Lys Gln Ala Arg 
    1730                1735                1740                

Leu Leu Gln Val Gly Gln Ala Leu Glu Leu Pro Thr Lys Val Pro Val 
1745                1750                1755                1760

Tyr Phe Thr Gly Lys Asp Gly Tyr Glu Thr Lys Asp Leu Thr Val Glu 
                1765                1770                1775    

Trp Glu Glu Val Pro Ala Glu Asn Leu Thr Lys Ala Gly Gln Phe Thr 
            1780                1785                1790        

Val Arg Gly Arg Val Leu Gly Ser Asn Leu Val Ala Glu Val Thr Val 
        1795                1800                1805            

Arg Val Thr Asp Lys Leu Gly Glu Thr Leu Ser Asp Asn Pro Asn Tyr 
    1810                1815                1820                

Asp Glu Asn Ser Asn Gln Ala Phe Ala Ser Ala Thr Asn Asp Ile Asp 
1825                1830                1835                1840

Lys Asn Ser His Asp Arg Val Asp Tyr Leu Asn Asp Gly Asp His Ser 
                1845                1850                1855    

Glu Asn Arg Arg Trp Thr Asn Trp Ser Pro Thr Pro Ser Ser Asn Pro 
            1860                1865                1870        

Glu Val Ser Ala Gly Val Ile Phe Arg Glu Asn Gly Lys Ile Val Glu 
        1875                1880                1885            

Arg Thr Val Ala Gln Ala Lys Leu His Phe Phe Ala Asp Ser Gly Thr 
    1890                1895                1900                

Asp Ala Pro Ser Lys Leu Val Leu Glu Arg Tyr Val Gly Pro Gly Phe 
1905                1910                1915                1920

Glu Val Pro Thr Tyr Tyr Ser Asn Tyr Gln Ala Tyr Glu Ser Gly His 
                1925                1930                1935    

Pro Phe Asn Asn Pro Glu Asn Trp Glu Ala Val Pro Tyr Arg Ala Asp 
            1940                1945                1950        

Lys Asp Ile Ala Ala Gly Asp Glu Ile Asn Val Thr Phe Lys Ala Val 
        1955                1960                1965            

Lys Ala Lys Val Met Arg Trp Arg Met Glu Arg Lys Ala Asp Lys Ser 
    1970                1975                1980                

Gly Val Ala Met Ile Glu Met Thr Phe Leu Ala Pro Ser Glu Leu Pro 
1985                1990                1995                2000

Gln Glu Ser Thr Gln Ser Lys Ile Leu Val Asp Gly Lys Glu Leu Ala 
                2005                2010                2015    

Asp Phe Ala Glu Asn Arg Gln Asp Tyr Gln Ile Thr Tyr Lys Gly Gln 
            2020                2025                2030        

Arg Pro Lys Val Ser Val Glu Glu Asn Asn Gln Val Ala Ser Thr Val 
        2035                2040                2045            

Val Asp Ser Gly Glu Asp Ser Leu Pro Val Leu Val Arg Leu Val Ser 
    2050                2055                2060                

Glu Ser Gly Lys Gln Val Lys Glu Tyr Arg Ile Gln Leu Thr Lys Glu 
2065                2070                2075                2080

Lys Pro Val Ser Ala Val Gln Glu Asp Leu Pro Lys Leu Glu Phe Val 
                2085                2090                2095    

Glu Lys Asp Leu Ala Tyr Lys Thr Val Glu Lys Lys Asp Ser Thr Leu 
            2100                2105                2110        

Tyr Leu Gly Glu Thr Arg Val Glu Gln Glu Gly Lys Val Gly Lys Glu 
        2115                2120                2125            

Arg Ile Phe Thr Val Ile Asn Pro Asp Gly Ser Lys Glu Glu Lys Leu 
    2130                2135                2140                

Arg Glu Val Val Glu Val Pro Thr Asp Arg Ile Val Leu Val Gly Thr 
2145                2150                2155                2160

Lys Pro Val Ala Gln Glu Ala Lys Lys Pro Gln Val Ser Glu Lys Ala 
                2165                2170                2175    

Asp Thr Lys Pro Ile Asp Ser Ser Glu Ala Asp Gln Thr Asn Lys Ala 
            2180                2185                2190        

Gln Leu Pro Asn Thr Gly Ser Ala Ala Ser Gln Ala Ala Val Ala Ala 
        2195                2200                2205            

Gly Leu Ala Leu Leu Gly Leu Ser Ala Gly Leu Val Val Thr Lys Gly 
    2210                2215                2220                

Lys Lys Glu Asp 
2225            

<210>   261
<211>   247
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length spr1098 as found in the R6 strain

<400>   261
Met Ser Gln Lys Asn Asn Lys Lys Lys Asn Lys Arg Lys Asn Leu Leu 
1               5                   10                  15      

Thr Asn Ile Leu Ala Gly Phe Leu Ile Leu Leu Ser Leu Ala Leu Ile 
            20                  25                  30          

Phe Asn Thr Gln Ile Arg Asn Ile Phe Ile Val Trp Asn Thr Asn Lys 
        35                  40                  45              

Tyr Gln Val Ser Gln Val Ser Lys Glu Lys Leu Glu Glu Asn Gln Asp 
    50                  55                  60                  

Thr Glu Gly Asn Phe Asp Phe Asp Ser Val Lys Ala Ile Ser Ser Glu 
65                  70                  75                  80  

Ala Val Leu Thr Ser Gln Trp Asp Ala Gln Lys Leu Pro Val Ile Gly 
                85                  90                  95      

Gly Ile Ala Ile Pro Glu Leu Glu Met Asn Leu Pro Ile Phe Lys Gly 
            100                 105                 110         

Leu Asp Asn Val Asn Leu Phe Tyr Gly Ala Gly Thr Met Lys Arg Glu 
        115                 120                 125             

Gln Val Met Gly Glu Gly Asn Tyr Ser Leu Ala Ser His His Ile Phe 
    130                 135                 140                 

Gly Val Asp Asn Ala Asn Lys Met Leu Phe Ser Pro Leu Asp Asn Ala 
145                 150                 155                 160 

Lys Asn Gly Met Lys Ile Tyr Leu Thr Asp Lys Asn Lys Val Tyr Thr 
                165                 170                 175     

Tyr Glu Ile Arg Glu Val Lys Arg Val Thr Pro Asp Arg Val Asp Glu 
            180                 185                 190         

Val Asp Asp Arg Asp Gly Val Asn Glu Ile Thr Leu Val Thr Cys Glu 
        195                 200                 205             

Asp Leu Ala Ala Thr Glu Arg Ile Ile Val Lys Gly Asp Leu Lys Glu 
    210                 215                 220                 

Thr Lys Asp Tyr Ser Gln Thr Ser Asp Glu Ile Leu Thr Ala Phe Asn 
225                 230                 235                 240 

Gln Pro Tyr Lys Gln Phe Tyr 
                245         

<210>   262
<211>   1062
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   a variant of SEQ ID NO: 259 based on a different wild-type strain

<400>   262
Leu His Leu Leu Val Gly Asn Asp Gly Leu Arg Phe Met Leu Asp Asp 
1               5                   10                  15      

Met Ser Ile Thr Ala Asn Gly Lys Thr Tyr Ala Ser Asp Asp Val Lys 
            20                  25                  30          

Arg Ala Ile Glu Lys Gly Thr Asn Asp Tyr Tyr Asn Asp Pro Asn Gly 
        35                  40                  45              

Asn His Leu Thr Glu Ser Gln Met Thr Asp Leu Ile Asn Tyr Ala Lys 
    50                  55                  60                  

Asp Lys Gly Ile Gly Leu Ile Pro Thr Val Asn Ser Pro Gly His Met 
65                  70                  75                  80  

Asp Ala Ile Leu Asn Ala Met Lys Glu Leu Gly Ile Gln Asn Pro Asn 
                85                  90                  95      

Phe Ser Tyr Phe Gly Lys Lys Ser Ala Arg Thr Val Asp Leu Asp Asn 
            100                 105                 110         

Glu Gln Ala Val Ala Phe Thr Lys Ala Leu Ile Asp Lys Tyr Ala Ala 
        115                 120                 125             

Tyr Phe Ala Lys Lys Thr Glu Ile Phe Asn Ile Gly Leu Asp Glu Tyr 
    130                 135                 140                 

Ala Asn Asp Ala Thr Asp Ala Lys Gly Trp Ser Val Leu Gln Ala Asp 
145                 150                 155                 160 

Lys Tyr Tyr Pro Asn Glu Gly Tyr Pro Val Lys Gly Tyr Glu Lys Phe 
                165                 170                 175     

Ile Ala Tyr Ala Asn Asp Leu Ala Arg Ile Val Lys Ser His Gly Leu 
            180                 185                 190         

Lys Pro Met Ala Phe Asn Asp Gly Ile Tyr Tyr Asn Ser Asp Thr Ser 
        195                 200                 205             

Phe Gly Ser Phe Asp Lys Asp Ile Ile Val Ser Met Trp Thr Gly Gly 
    210                 215                 220                 

Trp Gly Gly Tyr Asp Val Ala Ser Ser Lys Leu Leu Ala Glu Lys Gly 
225                 230                 235                 240 

His Gln Ile Leu Asn Thr Asn Asp Ala Trp Tyr Tyr Val Leu Gly Arg 
                245                 250                 255     

Asn Ala Asp Gly Gln Gly Trp Tyr Asn Leu Asp Gln Gly Leu Asn Gly 
            260                 265                 270         

Ile Lys Asn Thr Pro Ile Thr Ser Val Pro Lys Thr Glu Gly Ala Asp 
        275                 280                 285             

Ile Pro Ile Ile Gly Gly Met Val Ala Ala Trp Ala Asp Thr Pro Ser 
    290                 295                 300                 

Ala Arg Tyr Ser Pro Ser Arg Leu Phe Lys Leu Met Arg His Phe Ala 
305                 310                 315                 320 

Asn Ala Asn Ala Glu Tyr Phe Ala Ala Asp Tyr Glu Ser Ala Glu Gln 
                325                 330                 335     

Ala Leu Asn Glu Val Pro Lys Asp Leu Asn Arg Tyr Thr Ala Glu Ser 
            340                 345                 350         

Val Thr Ala Val Lys Glu Ala Glu Lys Ala Ile Arg Ser Leu Asp Ser 
        355                 360                 365             

Asn Leu Ser Arg Ala Gln Gln Asp Thr Ile Asp Gln Ala Ile Ala Lys 
    370                 375                 380                 

Leu Gln Glu Thr Val Asn Asn Leu Thr Leu Thr Pro Glu Ala Gln Lys 
385                 390                 395                 400 

Glu Glu Glu Ala Lys Arg Glu Val Glu Lys Leu Ala Lys Asn Lys Val 
                405                 410                 415     

Ile Ser Ile Asp Ala Gly Arg Lys Tyr Phe Thr Leu Asn Gln Leu Lys 
            420                 425                 430         

Arg Ile Val Asp Lys Ala Ser Glu Leu Gly Tyr Ser Asp Val His Leu 
        435                 440                 445             

Leu Leu Gly Asn Asp Gly Leu Arg Phe Leu Leu Asp Asp Met Thr Ile 
    450                 455                 460                 

Thr Ala Asn Gly Lys Thr Tyr Ala Ser Asp Asp Val Lys Lys Ala Ile 
465                 470                 475                 480 

Ile Glu Gly Thr Lys Ala Tyr Tyr Asp Asp Pro Asn Gly Thr Ala Leu 
                485                 490                 495     

Thr Gln Ala Glu Val Thr Glu Leu Ile Glu Tyr Ala Lys Ser Lys Asp 
            500                 505                 510         

Ile Gly Leu Ile Pro Ala Ile Asn Ser Pro Gly His Met Asp Ala Met 
        515                 520                 525             

Leu Val Ala Met Glu Lys Leu Gly Ile Lys Asn Pro Gln Ala His Phe 
    530                 535                 540                 

Asp Lys Val Ser Lys Thr Thr Met Asp Leu Lys Asn Glu Glu Ala Met 
545                 550                 555                 560 

Asn Phe Val Lys Ala Leu Ile Gly Lys Tyr Met Asp Phe Phe Ala Gly 
                565                 570                 575     

Lys Thr Lys Ile Phe Asn Phe Gly Thr Asp Glu Tyr Ala Asn Asp Ala 
            580                 585                 590         

Thr Ser Ala Gln Gly Trp Tyr Tyr Leu Lys Trp Tyr Gln Leu Tyr Gly 
        595                 600                 605             

Lys Phe Ala Glu Tyr Ala Asn Thr Leu Ala Ala Met Ala Lys Glu Arg 
    610                 615                 620                 

Gly Leu Gln Pro Met Ala Phe Asn Asp Gly Phe Tyr Tyr Glu Asp Lys 
625                 630                 635                 640 

Asp Asp Val Gln Phe Asp Lys Asp Val Leu Ile Ser Tyr Trp Ser Lys 
                645                 650                 655     

Gly Trp Trp Gly Tyr Asn Leu Ala Ser Pro Gln Tyr Leu Ala Ser Lys 
            660                 665                 670         

Gly Tyr Lys Phe Leu Asn Thr Asn Gly Asp Trp Tyr Tyr Ile Leu Gly 
        675                 680                 685             

Gln Lys Pro Glu Asp Gly Gly Gly Phe Leu Lys Lys Ala Ile Glu Asn 
    690                 695                 700                 

Thr Gly Lys Thr Pro Phe Asn Gln Leu Ala Ser Thr Lys Tyr Pro Glu 
705                 710                 715                 720 

Val Asp Leu Pro Thr Val Gly Ser Met Leu Ser Ile Trp Ala Asp Arg 
                725                 730                 735     

Pro Ser Ala Glu Tyr Lys Glu Glu Glu Ile Phe Glu Leu Met Thr Ala 
            740                 745                 750         

Phe Ala Asp His Asn Lys Asp Tyr Phe Arg Ala Asn Tyr Asn Ala Leu 
        755                 760                 765             

Arg Glu Glu Leu Ala Lys Ile Pro Thr Asn Leu Glu Gly Tyr Ser Lys 
    770                 775                 780                 

Glu Ser Leu Glu Ala Leu Asp Ala Ala Lys Thr Ala Leu Asn Tyr Asn 
785                 790                 795                 800 

Leu Asn Arg Asn Lys Gln Ala Glu Leu Asp Thr Leu Val Ala Asn Leu 
                805                 810                 815     

Lys Ala Ala Leu Gln Gly Leu Lys Pro Ala Val Thr His Ser Gly Ser 
            820                 825                 830         

Leu Asp Glu Asn Glu Val Ala Ala Asn Val Glu Thr Arg Pro Glu Leu 
        835                 840                 845             

Ile Thr Arg Thr Glu Glu Ile Pro Phe Glu Val Ile Lys Lys Glu Asn 
    850                 855                 860                 

Pro Asn Leu Pro Ala Gly Gln Glu Asn Ile Ile Thr Ala Gly Val Lys 
865                 870                 875                 880 

Gly Glu Arg Thr His Tyr Ile Ser Val Leu Thr Glu Asn Gly Lys Thr 
                885                 890                 895     

Thr Glu Thr Val Leu Asp Ser Gln Val Thr Lys Glu Val Ile Asn Gln 
            900                 905                 910         

Val Val Glu Val Gly Ala Pro Val Thr His Lys Gly Asp Glu Ser Gly 
        915                 920                 925             

Leu Ala Pro Thr Thr Glu Val Lys Pro Arg Leu Asp Ile Gln Glu Glu 
    930                 935                 940                 

Glu Ile Pro Phe Thr Thr Val Thr Cys Glu Asn Pro Leu Leu Leu Lys 
945                 950                 955                 960 

Gly Lys Thr Gln Val Ile Thr Lys Gly Val Asn Gly His Arg Ser Asn 
                965                 970                 975     

Phe Tyr Ser Val Ser Thr Ser Ala Asp Gly Lys Glu Val Lys Thr Leu 
            980                 985                 990         

Val Asn Ser Val Val Ala Gln Glu Ala Val Thr Gln Ile Val Glu Val 
        995                 1000                1005            

Gly Thr Met Val Thr His Val Gly Asp Glu Asn Gly Gln Ala Ala Ile 
    1010                1015                1020                

Ala Glu Glu Lys Pro Lys Leu Glu Ile Pro Ser Gln Pro Ala Pro Ser 
1025                1030                1035                1040

Thr Ala Pro Ala Glu Glu Ser Lys Val Leu Pro Gln Asp Pro Ala Pro 
                1045                1050                1055    

Val Val Thr Glu Lys Lys 
            1060        

<210>   263
<211>   128
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length spr1416 as found in the R6 strain

<400>   263
Met Glu Lys Asp Met Asn Leu Lys Arg Glu Gln Glu Phe Val Ser Gln 
1               5                   10                  15      

Tyr His Phe Asp Ala Arg Asn Phe Glu Trp Glu Asn Glu Asn Gly Ala 
            20                  25                  30          

Pro Glu Thr Lys Val Asp Val Asn Phe Gln Leu Leu Gln His Asp Gln 
        35                  40                  45              

Glu Asn Gln Val Thr Ser Leu Ile Val Ile Leu Ser Phe Met Ile Val 
    50                  55                  60                  

Phe Asp Lys Phe Val Ile Ser Gly Thr Ile Ser Gln Val Asn His Ile 
65                  70                  75                  80  

Asp Gly Arg Ile Val Asn Glu Pro Asn Glu Leu Asn Gln Glu Glu Val 
                85                  90                  95      

Glu Thr Leu Ala Arg Pro Cys Leu Asn Met Leu Asn Arg Leu Thr Tyr 
            100                 105                 110         

Glu Val Thr Glu Ile Ala Leu Asp Leu Pro Gly Ile Asn Leu Glu Phe 
        115                 120                 125             


<210>   264
<211>   259
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length spr1418 as found in the R6 strain

<400>   264
Met Lys Lys Asn Ser Leu Tyr Ile Ile Ser Ser Leu Phe Phe Ala Cys 
1               5                   10                  15      

Val Leu Phe Val Tyr Ala Thr Ala Thr Asn Phe Gln Asn Ser Thr Ser 
            20                  25                  30          

Ala Arg Gln Val Lys Thr Glu Thr Tyr Thr Asn Thr Val Thr Asn Val 
        35                  40                  45              

Pro Ile Asp Ile Arg Tyr Asn Ser Asp Lys Tyr Phe Ile Ser Gly Phe 
    50                  55                  60                  

Ala Ser Glu Val Ser Val Val Leu Thr Gly Ala Asn Arg Leu Ser Leu 
65                  70                  75                  80  

Ala Ser Glu Met Gln Glu Ser Thr Arg Lys Phe Lys Val Thr Ala Asp 
                85                  90                  95      

Leu Thr Asp Ala Gly Val Gly Thr Ile Glu Val Pro Leu Ser Ile Glu 
            100                 105                 110         

Asp Leu Pro Asn Gly Leu Thr Ala Val Ala Thr Pro Gln Lys Ile Thr 
        115                 120                 125             

Val Lys Ile Gly Lys Lys Ala Gln Lys Asp Lys Val Lys Ile Val Pro 
    130                 135                 140                 

Glu Ile Asp Pro Ser Gln Ile Asp Ser Arg Val Gln Ile Glu Asn Val 
145                 150                 155                 160 

Met Val Ser Asp Lys Glu Val Ser Ile Thr Ser Asp Gln Glu Thr Leu 
                165                 170                 175     

Asp Arg Ile Asp Lys Ile Ile Ala Val Leu Pro Thr Ser Glu Arg Ile 
            180                 185                 190         

Thr Gly Asn Tyr Ser Gly Ser Val Pro Leu Gln Ala Ile Asp Arg Asn 
        195                 200                 205             

Gly Val Val Leu Pro Ala Val Ile Thr Pro Phe Asp Thr Ile Met Lys 
    210                 215                 220                 

Val Thr Thr Lys Pro Val Ala Pro Ser Ser Ser Thr Ser Asn Ser Ser 
225                 230                 235                 240 

Thr Ser Ser Ser Ser Glu Thr Ser Ser Ser Thr Lys Ala Thr Ser Ser 
                245                 250                 255     

Lys Thr Asn 
            

<210>   265
<211>   721
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length spr0867 as found in the R6 strain

<400>   265
Met Asn Leu Gly Glu Phe Trp Tyr Asn Lys Ile Asn Lys Asn Arg Gly 
1               5                   10                  15      

Arg Arg Leu Met Lys Lys Val Arg Phe Ile Phe Leu Ala Leu Leu Phe 
            20                  25                  30          

Phe Leu Ala Ser Pro Glu Gly Ala Met Ala Ser Asp Gly Thr Trp Gln 
        35                  40                  45              

Gly Lys Gln Tyr Leu Lys Glu Asp Gly Ser Gln Ala Ala Asn Glu Trp 
    50                  55                  60                  

Val Phe Asp Thr His Tyr Gln Ser Trp Phe Tyr Ile Lys Ala Asp Ala 
65                  70                  75                  80  

Asn Tyr Ala Glu Asn Glu Trp Leu Lys Gln Gly Asp Asp Tyr Phe Tyr 
                85                  90                  95      

Leu Lys Ser Gly Gly Tyr Met Ala Lys Ser Glu Trp Val Glu Asp Lys 
            100                 105                 110         

Gly Ala Phe Tyr Tyr Leu Asp Gln Asp Gly Lys Met Lys Arg Asn Ala 
        115                 120                 125             

Trp Val Gly Thr Ser Tyr Val Gly Ala Thr Gly Ala Lys Val Ile Glu 
    130                 135                 140                 

Asp Trp Val Tyr Asp Ser Gln Tyr Asp Ala Trp Phe Tyr Ile Lys Ala 
145                 150                 155                 160 

Asp Gly Gln His Ala Glu Lys Glu Trp Leu Gln Ile Lys Gly Lys Asp 
                165                 170                 175     

Tyr Tyr Phe Lys Ser Gly Gly Tyr Leu Leu Thr Ser Gln Trp Ile Asn 
            180                 185                 190         

Gln Ala Tyr Val Asn Ala Ser Gly Ala Lys Val Gln Gln Gly Trp Leu 
        195                 200                 205             

Phe Asp Lys Gln Tyr Gln Ser Trp Phe Tyr Ile Lys Glu Asn Gly Asn 
    210                 215                 220                 

Tyr Ala Asp Lys Glu Trp Ile Phe Glu Asn Gly His Tyr Tyr Tyr Leu 
225                 230                 235                 240 

Lys Ser Gly Gly Tyr Met Ala Ala Asn Glu Trp Ile Trp Asp Lys Glu 
                245                 250                 255     

Ser Trp Phe Tyr Leu Lys Phe Asp Gly Lys Ile Ala Glu Lys Glu Trp 
            260                 265                 270         

Val Tyr Asp Ser His Ser Gln Ala Trp Tyr Tyr Phe Lys Ser Gly Gly 
        275                 280                 285             

Tyr Met Ala Ala Asn Glu Trp Ile Trp Asp Lys Glu Ser Trp Phe Tyr 
    290                 295                 300                 

Leu Lys Phe Asp Gly Lys Met Ala Glu Lys Glu Trp Val Tyr Asp Ser 
305                 310                 315                 320 

His Ser Gln Ala Trp Tyr Tyr Phe Lys Ser Gly Gly Tyr Met Thr Ala 
                325                 330                 335     

Asn Glu Trp Ile Trp Asp Lys Glu Ser Trp Phe Tyr Leu Lys Ser Asp 
            340                 345                 350         

Gly Lys Ile Ala Glu Lys Glu Trp Val Tyr Asp Ser His Ser Gln Ala 
        355                 360                 365             

Trp Tyr Tyr Phe Lys Ser Gly Gly Tyr Met Thr Ala Asn Glu Trp Ile 
    370                 375                 380                 

Trp Asp Lys Glu Ser Trp Phe Tyr Leu Lys Ser Asp Gly Lys Met Ala 
385                 390                 395                 400 

Glu Lys Glu Trp Val Tyr Asp Ser His Ser Gln Ala Trp Tyr Tyr Phe 
                405                 410                 415     

Lys Ser Gly Gly Tyr Met Ala Lys Asn Glu Thr Val Asp Gly Tyr Gln 
            420                 425                 430         

Leu Gly Ser Asp Gly Lys Trp Leu Gly Gly Lys Ala Thr Asn Lys Asn 
        435                 440                 445             

Ala Ala Tyr Tyr Gln Val Val Pro Val Thr Ala Asn Val Tyr Asp Ser 
    450                 455                 460                 

Asp Gly Glu Lys Leu Ser Tyr Ile Ser Gln Gly Ser Val Val Trp Leu 
465                 470                 475                 480 

Asp Lys Asp Arg Lys Ser Asp Asp Lys Arg Leu Ala Ile Thr Ile Ser 
                485                 490                 495     

Gly Leu Ser Gly Tyr Met Lys Thr Glu Asp Leu Gln Ala Leu Asp Ala 
            500                 505                 510         

Ser Lys Asp Phe Ile Pro Tyr Tyr Glu Ser Asp Gly His Arg Phe Tyr 
        515                 520                 525             

His Tyr Val Ala Gln Asn Ala Ser Ile Pro Val Ala Ser His Leu Ser 
    530                 535                 540                 

Asp Met Glu Val Gly Lys Lys Tyr Tyr Ser Ala Asp Gly Leu His Phe 
545                 550                 555                 560 

Asp Gly Phe Lys Leu Glu Asn Pro Phe Leu Phe Lys Asp Leu Thr Glu 
                565                 570                 575     

Ala Thr Asn Tyr Ser Ala Glu Glu Leu Asp Lys Val Phe Ser Leu Leu 
            580                 585                 590         

Asn Ile Asn Asn Ser Leu Leu Glu Asn Lys Gly Ala Thr Phe Lys Glu 
        595                 600                 605             

Ala Glu Glu His Tyr His Ile Asn Ala Leu Tyr Leu Leu Ala His Ser 
    610                 615                 620                 

Ala Leu Glu Ser Asn Trp Gly Arg Ser Lys Ile Ala Lys Asp Lys Asn 
625                 630                 635                 640 

Asn Phe Phe Gly Ile Thr Ala Tyr Asp Thr Thr Pro Tyr Leu Ser Ala 
                645                 650                 655     

Lys Thr Phe Asp Asp Val Asp Lys Gly Ile Leu Gly Ala Thr Lys Trp 
            660                 665                 670         

Ile Lys Glu Asn Tyr Ile Asp Arg Gly Arg Thr Phe Leu Gly Asn Lys 
        675                 680                 685             

Ala Ser Gly Met Asn Val Glu Tyr Ala Ser Asp Pro Tyr Trp Gly Glu 
    690                 695                 700                 

Lys Ile Ala Ser Val Met Met Lys Ile Asn Glu Lys Leu Gly Gly Lys 
705                 710                 715                 720 

Asp 
    

<210>   266
<211>   501
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length spr1431 as found in the R6 strain

<400>   266
Met Ser Val Thr Phe Phe Ile Gly Glu Glu Arg Leu Lys Ile Lys Ile 
1               5                   10                  15      

Gly Leu Ala Ser Ile Cys Leu Leu Gly Leu Ala Thr Ser His Val Ala 
            20                  25                  30          

Ala Asn Glu Thr Glu Val Ala Lys Thr Ser Gln Asp Thr Thr Thr Ala 
        35                  40                  45              

Ser Ser Ser Ser Glu Gln Asn Gln Ser Ser Asn Lys Thr Gln Thr Ser 
    50                  55                  60                  

Ala Glu Val Gln Thr Asn Ala Ala Ala Tyr Trp Asp Gly Asp Tyr Tyr 
65                  70                  75                  80  

Val Lys Asp Asp Gly Ser Lys Ala Gln Ser Glu Trp Ile Phe Asp Asn 
                85                  90                  95      

Tyr Tyr Lys Ala Trp Phe Tyr Ile Asn Ser Asp Gly Arg Tyr Ser Gln 
            100                 105                 110         

Asn Glu Trp His Gly Asn Tyr Tyr Leu Lys Ser Gly Gly Tyr Met Ala 
        115                 120                 125             

Gln Asn Glu Trp Ile Tyr Asp Ser Asn Tyr Lys Ser Trp Phe Tyr Leu 
    130                 135                 140                 

Lys Ser Asp Gly Ala Tyr Ala His Gln Glu Trp Gln Leu Ile Gly Asn 
145                 150                 155                 160 

Lys Trp Tyr Tyr Phe Lys Lys Trp Gly Tyr Met Ala Lys Ser Gln Trp 
                165                 170                 175     

Gln Gly Ser Tyr Phe Leu Asn Gly Gln Gly Ala Met Ile Gln Asn Glu 
            180                 185                 190         

Trp Leu Tyr Asp Pro Ala Tyr Ser Ala Tyr Phe Tyr Leu Lys Ser Asp 
        195                 200                 205             

Gly Thr Tyr Ala Asn Gln Glu Trp Gln Lys Val Gly Gly Lys Trp Tyr 
    210                 215                 220                 

Tyr Phe Lys Lys Trp Gly Tyr Met Ala Arg Asn Glu Trp Gln Gly Asn 
225                 230                 235                 240 

Tyr Tyr Leu Thr Gly Ser Gly Ala Met Ala Thr Asp Glu Val Ile Met 
                245                 250                 255     

Asp Gly Ala Arg Tyr Ile Phe Ala Ala Ser Gly Glu Leu Lys Glu Lys 
            260                 265                 270         

Lys Asp Leu Asn Val Gly Trp Val His Arg Asp Gly Lys Arg Tyr Phe 
        275                 280                 285             

Phe Asn Asn Arg Glu Glu Gln Val Gly Thr Glu His Ala Lys Lys Ile 
    290                 295                 300                 

Ile Asp Ile Ser Glu His Asn Gly Arg Ile Asn Asp Trp Lys Lys Val 
305                 310                 315                 320 

Ile Asp Glu Asn Lys Val Asp Gly Val Ile Val Arg Leu Gly Tyr Ser 
                325                 330                 335     

Gly Lys Glu Asp Lys Glu Leu Ala His Asn Ile Lys Glu Leu Asn Arg 
            340                 345                 350         

Leu Gly Ile Pro Tyr Gly Val Tyr Leu Tyr Thr Tyr Ala Glu Asn Glu 
        355                 360                 365             

Thr Asp Ala Glu Asn Asp Ala Lys Gln Thr Ile Glu Leu Ile Lys Lys 
    370                 375                 380                 

Tyr Asn Met Asn Leu Ser Tyr Pro Ile Tyr Tyr Asp Val Glu Asn Trp 
385                 390                 395                 400 

Glu Tyr Val Asn Lys Ser Lys Arg Ala Pro Ser Asp Thr Asp Thr Trp 
                405                 410                 415     

Val Lys Ile Ile Asn Lys Tyr Met Asp Thr Met Lys Gln Ala Gly Tyr 
            420                 425                 430         

Gln Asn Val Tyr Val Tyr Ser Tyr Arg Ser Leu Leu Gln Thr Arg Leu 
        435                 440                 445             

Lys His Pro Asp Ile Leu Lys His Val Asn Trp Val Ala Ala Tyr Thr 
    450                 455                 460                 

Asn Ala Leu Glu Trp Glu Asn Pro Tyr Tyr Ser Gly Glu Lys Gly Trp 
465                 470                 475                 480 

Gln Tyr Thr Ser Ser Glu Tyr Met Lys Gly Ile Gln Gly Arg Val Asp 
                485                 490                 495     

Val Ser Val Trp Tyr 
            500     

<210>   267
<211>   471
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length spr1739 as found in the R6 strain

<400>   267
Met Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp 
1               5                   10                  15      

Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe 
            20                  25                  30          

Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg 
        35                  40                  45              

Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala 
    50                  55                  60                  

Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
65                  70                  75                  80  

Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
                85                  90                  95      

Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
            100                 105                 110         

Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
        115                 120                 125             

Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
    130                 135                 140                 

Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln 
145                 150                 155                 160 

Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
                165                 170                 175     

Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
            180                 185                 190         

Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
        195                 200                 205             

Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
    210                 215                 220                 

Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val 
225                 230                 235                 240 

Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
                245                 250                 255     

Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val 
            260                 265                 270         

Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys 
        275                 280                 285             

Ala Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr 
    290                 295                 300                 

Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe 
305                 310                 315                 320 

Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu 
                325                 330                 335     

Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu 
            340                 345                 350         

Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser 
        355                 360                 365             

Gly Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asp Glu Leu Ser Tyr 
    370                 375                 380                 

Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn 
385                 390                 395                 400 

Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly 
                405                 410                 415     

Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala 
            420                 425                 430         

Trp Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val 
        435                 440                 445             

Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gln Val 
    450                 455                 460                 

Glu Asp Lys Val Glu Asn Asp 
465                 470     

<210>   268
<211>   392
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   spr2021 as found in the R6 strain

<400>   268
Met Lys Lys Lys Ile Leu Ala Ser Leu Leu Leu Ser Thr Val Met Val 
1               5                   10                  15      

Ser Gln Val Ala Val Leu Thr Thr Ala His Ala Glu Thr Thr Asp Asp 
            20                  25                  30          

Lys Ile Ala Ala Gln Asp Asn Lys Ile Ser Asn Leu Thr Ala Gln Gln 
        35                  40                  45              

Gln Glu Ala Gln Lys Gln Val Asp Gln Ile Gln Glu Gln Val Ser Ala 
    50                  55                  60                  

Ile Gln Ala Glu Gln Ser Asn Leu Gln Ala Glu Asn Asp Arg Leu Gln 
65                  70                  75                  80  

Ala Glu Ser Lys Lys Leu Glu Gly Glu Ile Thr Glu Leu Ser Lys Asn 
                85                  90                  95      

Ile Val Ser Arg Asn Gln Ser Leu Glu Lys Gln Ala Arg Ser Ala Gln 
            100                 105                 110         

Thr Asn Gly Ala Val Thr Ser Tyr Ile Asn Thr Ile Val Asn Ser Lys 
        115                 120                 125             

Ser Ile Thr Glu Ala Ile Ser Arg Val Ala Ala Met Ser Glu Ile Val 
    130                 135                 140                 

Ser Ala Asn Asn Lys Met Leu Glu Gln Gln Lys Ala Asp Lys Lys Ala 
145                 150                 155                 160 

Ile Ser Glu Lys Gln Val Ala Asn Asn Asp Ala Ile Asn Thr Val Ile 
                165                 170                 175     

Ala Asn Gln Gln Lys Leu Ala Asp Asp Ala Gln Ala Leu Thr Thr Lys 
            180                 185                 190         

Gln Ala Glu Leu Lys Ala Ala Glu Leu Ser Leu Ala Ala Glu Lys Ala 
        195                 200                 205             

Thr Ala Glu Gly Glu Lys Ala Ser Leu Leu Glu Gln Lys Ala Ala Ala 
    210                 215                 220                 

Glu Ala Glu Ala Arg Ala Ala Ala Val Ala Glu Ala Ala Tyr Lys Glu 
225                 230                 235                 240 

Lys Arg Ala Ser Gln Gln Gln Ser Val Leu Ala Ser Ala Asn Thr Asn 
                245                 250                 255     

Leu Thr Ala Gln Val Gln Ala Val Ser Glu Ser Ala Ala Ala Pro Val 
            260                 265                 270         

Arg Ala Lys Val Arg Pro Thr Tyr Ser Thr Asn Ala Ser Ser Tyr Pro 
        275                 280                 285             

Ile Gly Glu Cys Thr Trp Gly Val Lys Thr Leu Ala Pro Trp Ala Gly 
    290                 295                 300                 

Asp Tyr Trp Gly Asn Gly Ala Gln Trp Ala Thr Ser Ala Ala Ala Ala 
305                 310                 315                 320 

Gly Phe Arg Thr Gly Ser Thr Pro Gln Val Gly Ala Ile Ala Cys Trp 
                325                 330                 335     

Asn Asp Gly Gly Tyr Gly His Val Ala Val Val Thr Ala Val Glu Ser 
            340                 345                 350         

Thr Thr Arg Ile Gln Val Ser Glu Ser Asn Tyr Ala Gly Asn Arg Thr 
        355                 360                 365             

Ile Gly Asn His Arg Gly Trp Phe Asn Pro Thr Thr Thr Ser Glu Gly 
    370                 375                 380                 

Phe Val Thr Tyr Ile Tyr Ala Asp 
385                 390         

<210>   269
<211>   167
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length spr0096 as found in the R6 strain

<400>   269
Met Lys Ser Ile Thr Lys Lys Ile Lys Ala Thr Leu Ala Gly Val Ala 
1               5                   10                  15      

Ala Leu Phe Ala Val Phe Ala Pro Ser Phe Val Ser Ala Gln Glu Ser 
            20                  25                  30          

Ser Thr Tyr Thr Val Lys Glu Gly Asp Thr Leu Ser Glu Ile Ala Glu 
        35                  40                  45              

Thr His Asn Thr Thr Val Glu Lys Leu Ala Glu Asn Asn His Ile Asp 
    50                  55                  60                  

Asn Ile His Leu Ile Tyr Val Asp Gln Glu Leu Val Ile Asp Gly Pro 
65                  70                  75                  80  

Val Ala Pro Val Ala Thr Pro Ala Pro Ala Thr Tyr Ala Ala Pro Ala 
                85                  90                  95      

Ala Gln Asp Glu Thr Val Ser Ala Pro Val Ala Glu Thr Pro Val Val 
            100                 105                 110         

Ser Glu Thr Val Val Ser Thr Val Ser Gly Ser Glu Ala Glu Ala Lys 
        115                 120                 125             

Glu Trp Ile Ala Gln Lys Glu Ser Gly Gly Ser Tyr Thr Ala Thr Asn 
    130                 135                 140                 

Gly Arg Tyr Ile Gly Arg Tyr Gly Ser Trp Thr Ala Ala Lys Asn Phe 
145                 150                 155                 160 

Trp Leu Asn Asn Gly Trp Tyr 
                165         

<210>   270
<211>   380
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length spr1875 as found in the R6 strain

<400>   270
Met Lys Lys Arg Met Leu Leu Ala Ser Thr Val Ala Leu Ser Phe Ala 
1               5                   10                  15      

Pro Val Leu Ala Thr Gln Ala Glu Glu Val Leu Trp Thr Ala Arg Ser 
            20                  25                  30          

Val Glu Gln Ile Gln Asn Asp Leu Thr Lys Thr Asp Asn Lys Thr Ser 
        35                  40                  45              

Tyr Thr Val Gln Tyr Gly Asp Thr Leu Ser Thr Ile Ala Glu Ala Leu 
    50                  55                  60                  

Gly Val Asp Val Thr Val Leu Ala Asn Leu Asn Lys Ile Thr Asn Met 
65                  70                  75                  80  

Asp Leu Ile Phe Pro Glu Thr Val Leu Thr Thr Thr Val Asn Glu Ala 
                85                  90                  95      

Glu Glu Val Thr Glu Val Glu Ile Gln Thr Pro Gln Ala Asp Ser Ser 
            100                 105                 110         

Glu Glu Val Thr Thr Ala Thr Ala Asp Leu Thr Thr Asn Gln Val Thr 
        115                 120                 125             

Val Asp Asp Gln Thr Val Gln Val Ala Asp Leu Ser Gln Pro Ile Ala 
    130                 135                 140                 

Glu Ala Pro Lys Glu Val Ala Ser Ser Ser Glu Val Thr Lys Thr Val 
145                 150                 155                 160 

Ile Ala Ser Glu Glu Val Ala Pro Ser Thr Gly Thr Ser Val Pro Glu 
                165                 170                 175     

Glu Gln Thr Ala Glu Thr Ser Ser Ala Val Ala Glu Glu Ala Pro Gln 
            180                 185                 190         

Glu Thr Thr Pro Ala Glu Lys Gln Glu Thr Gln Thr Ser Pro Gln Ala 
        195                 200                 205             

Ala Ser Ala Val Glu Ala Thr Thr Thr Ser Ser Glu Ala Lys Glu Val 
    210                 215                 220                 

Ala Ser Ser Asn Gly Ala Thr Ala Ala Val Ser Thr Tyr Gln Pro Glu 
225                 230                 235                 240 

Glu Thr Lys Ile Ile Ser Thr Thr Tyr Glu Ala Pro Ala Ala Pro Asp 
                245                 250                 255     

Tyr Ala Gly Leu Ala Val Ala Lys Ser Glu Asn Ala Gly Leu Gln Pro 
            260                 265                 270         

Gln Thr Ala Ala Phe Lys Glu Glu Ile Ala Asn Leu Phe Gly Ile Thr 
        275                 280                 285             

Ser Phe Ser Gly Tyr Arg Pro Gly Asp Ser Gly Asp His Gly Lys Gly 
    290                 295                 300                 

Leu Ala Ile Asp Phe Met Val Pro Glu Arg Ser Glu Leu Gly Asp Lys 
305                 310                 315                 320 

Ile Ala Glu Tyr Ala Ile Gln Asn Met Ala Ser Arg Gly Ile Ser Tyr 
                325                 330                 335     

Ile Ile Trp Lys Gln Arg Phe Tyr Ala Pro Phe Asp Ser Lys Tyr Gly 
            340                 345                 350         

Pro Ala Asn Thr Trp Asn Pro Met Pro Asp Arg Gly Ser Val Thr Glu 
        355                 360                 365             

Asn His Tyr Asp His Val His Val Ser Met Asn Gly 
    370                 375                 380 

<210>   271
<211>   659
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length spr1707 as found in the R6 strain

<400>   271
Met Lys Lys Asn Arg Val Phe Ala Thr Ala Gly Leu Val Leu Leu Ala 
1               5                   10                  15      

Ala Gly Val Leu Ala Ala Cys Ser Ser Ser Lys Ser Ser Asp Ser Ser 
            20                  25                  30          

Ala Pro Lys Ala Tyr Gly Tyr Val Tyr Thr Ala Asp Pro Glu Thr Leu 
        35                  40                  45              

Asp Tyr Leu Ile Ser Arg Lys Asn Ser Thr Thr Val Val Thr Ser Asn 
    50                  55                  60                  

Gly Ile Asp Gly Leu Phe Thr Asn Asp Asn Tyr Gly Asn Leu Ala Pro 
65                  70                  75                  80  

Ala Val Ala Glu Asp Trp Glu Val Ser Lys Asp Gly Leu Thr Tyr Thr 
                85                  90                  95      

Tyr Lys Ile Arg Lys Gly Val Lys Trp Phe Thr Ser Asp Gly Glu Glu 
            100                 105                 110         

Tyr Ala Glu Val Thr Ala Lys Asp Phe Val Asn Gly Leu Lys His Ala 
        115                 120                 125             

Ala Asp Lys Lys Ser Glu Ala Met Tyr Leu Ala Glu Asn Ser Val Lys 
    130                 135                 140                 

Gly Leu Ala Asp Tyr Leu Ser Gly Thr Ser Thr Asp Phe Ser Thr Val 
145                 150                 155                 160 

Gly Val Lys Ala Val Asp Asp Tyr Thr Leu Gln Tyr Thr Leu Asn Gln 
                165                 170                 175     

Pro Glu Pro Phe Trp Asn Ser Lys Leu Thr Tyr Ser Ile Phe Trp Pro 
            180                 185                 190         

Leu Asn Glu Glu Phe Glu Thr Ser Lys Gly Ser Asp Phe Ala Lys Pro 
        195                 200                 205             

Thr Asp Pro Thr Ser Leu Leu Tyr Asn Gly Pro Phe Leu Leu Lys Gly 
    210                 215                 220                 

Leu Thr Ala Lys Ser Ser Val Glu Phe Val Lys Asn Glu Gln Tyr Trp 
225                 230                 235                 240 

Asp Lys Glu Asn Val His Leu Asp Thr Ile Asn Leu Ala Tyr Tyr Asp 
                245                 250                 255     

Gly Ser Asp Gln Glu Ser Leu Glu Arg Asn Phe Thr Ser Gly Ala Tyr 
            260                 265                 270         

Ser Tyr Ala Arg Leu Tyr Pro Thr Ser Ser Asn Tyr Ser Lys Val Ala 
        275                 280                 285             

Glu Glu Tyr Lys Asp Asn Ile Tyr Tyr Thr Gln Ser Gly Ser Gly Ile 
    290                 295                 300                 

Ala Gly Leu Gly Val Asn Ile Asp Arg Gln Ser Tyr Asn Tyr Thr Ser 
305                 310                 315                 320 

Lys Thr Thr Asp Ser Glu Lys Val Ala Thr Lys Lys Ala Leu Leu Asn 
                325                 330                 335     

Lys Asp Phe Arg Gln Ala Leu Asn Phe Ala Leu Asp Arg Ser Ala Tyr 
            340                 345                 350         

Ser Ala Gln Ile Asn Gly Lys Asp Gly Ala Ala Leu Ala Val Arg Asn 
        355                 360                 365             

Leu Phe Val Lys Pro Asp Phe Val Ser Ala Gly Glu Lys Thr Phe Gly 
    370                 375                 380                 

Asp Leu Val Ala Ala Gln Leu Pro Ala Tyr Gly Asp Glu Trp Lys Gly 
385                 390                 395                 400 

Val Asn Leu Ala Asp Gly Gln Asp Gly Leu Phe Asn Ala Asp Lys Ala 
                405                 410                 415     

Lys Ala Glu Phe Ala Lys Ala Lys Lys Ala Leu Glu Ala Asp Gly Val 
            420                 425                 430         

Gln Phe Pro Ile His Leu Asp Val Pro Val Asp Gln Ala Ser Lys Asn 
        435                 440                 445             

Tyr Ile Ser Arg Ile Gln Ser Phe Lys Gln Ser Val Glu Thr Val Leu 
    450                 455                 460                 

Gly Val Glu Asn Val Val Val Asp Ile Gln Gln Met Thr Ser Asp Glu 
465                 470                 475                 480 

Phe Leu Asn Ile Thr Tyr Tyr Ala Ala Asn Ala Ser Ser Glu Asp Trp 
                485                 490                 495     

Asp Val Ser Gly Gly Val Ser Trp Gly Pro Asp Tyr Gln Asp Pro Ser 
            500                 505                 510         

Thr Tyr Leu Asp Ile Leu Lys Thr Thr Ser Ser Glu Thr Thr Lys Thr 
        515                 520                 525             

Tyr Leu Gly Phe Asp Asn Pro Asn Ser Pro Ser Val Val Gln Val Gly 
    530                 535                 540                 

Leu Lys Glu Tyr Asp Lys Leu Val Asp Glu Ala Ala Lys Glu Thr Ser 
545                 550                 555                 560 

Asp Leu Asn Val Arg Tyr Glu Lys Tyr Ala Ala Ala Gln Ala Trp Leu 
                565                 570                 575     

Thr Asp Ser Ser Leu Phe Ile Pro Ala Met Ala Ser Ser Gly Ala Ala 
            580                 585                 590         

Pro Val Leu Ser Arg Ile Val Pro Phe Thr Gly Ala Ser Ala Gln Thr 
        595                 600                 605             

Gly Ser Lys Gly Ser Asp Val Tyr Phe Lys Tyr Leu Lys Leu Gln Asp 
    610                 615                 620                 

Lys Ala Val Thr Lys Glu Glu Tyr Glu Lys Ala Arg Glu Lys Trp Leu 
625                 630                 635                 640 

Lys Glu Lys Ala Glu Ser Asn Glu Lys Ala Gln Lys Glu Leu Ala Ser 
                645                 650                 655     

His Val Lys 
            

<210>   272
<211>   313
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   amino acid sequence of full length spr0884

<400>   272
Met Lys Lys Lys Leu Leu Ala Gly Ala Ile Thr Leu Leu Ser Val Ala 
1               5                   10                  15      

Thr Leu Ala Ala Cys Ser Lys Gly Ser Glu Gly Ala Asp Leu Ile Ser 
            20                  25                  30          

Met Lys Gly Asp Val Ile Thr Glu His Gln Phe Tyr Glu Gln Val Lys 
        35                  40                  45              

Asn Asn Pro Ser Ala Gln Gln Val Leu Leu Asn Met Thr Ile Gln Lys 
    50                  55                  60                  

Val Phe Glu Lys Gln Tyr Gly Ser Glu Leu Asp Asp Lys Glu Val Asp 
65                  70                  75                  80  

Asp Thr Ile Ala Glu Glu Lys Lys Gln Tyr Gly Glu Asn Tyr Gln Arg 
                85                  90                  95      

Val Leu Ser Gln Ala Gly Met Thr Leu Glu Thr Arg Lys Ala Gln Ile 
            100                 105                 110         

Arg Thr Ser Lys Leu Val Glu Leu Ala Val Lys Lys Val Ala Glu Ala 
        115                 120                 125             

Glu Leu Thr Asp Glu Ala Tyr Lys Lys Ala Phe Asp Glu Tyr Thr Pro 
    130                 135                 140                 

Asp Val Thr Ala Gln Ile Ile Arg Leu Asn Asn Glu Asp Lys Ala Lys 
145                 150                 155                 160 

Glu Val Leu Glu Lys Ala Lys Ala Glu Gly Ala Asp Phe Ala Gln Leu 
                165                 170                 175     

Ala Lys Asp Asn Ser Thr Asp Glu Lys Thr Lys Glu Asn Gly Gly Glu 
            180                 185                 190         

Ile Thr Phe Asp Ser Ala Ser Thr Glu Val Pro Glu Gln Val Lys Lys 
        195                 200                 205             

Ala Ala Phe Ala Leu Asp Val Asp Gly Val Ser Asp Val Ile Thr Ala 
    210                 215                 220                 

Thr Gly Thr Gln Ala Tyr Ser Ser Gln Tyr Tyr Ile Val Lys Leu Thr 
225                 230                 235                 240 

Lys Lys Thr Glu Lys Ser Ser Asn Ile Asp Asp Tyr Lys Glu Lys Leu 
                245                 250                 255     

Lys Thr Val Ile Leu Thr Gln Lys Gln Asn Asp Ser Thr Phe Val Gln 
            260                 265                 270         

Ser Ile Ile Gly Lys Glu Leu Gln Ala Ala Asn Ile Lys Val Lys Asp 
        275                 280                 285             

Gln Ala Phe Gln Asn Ile Phe Thr Gln Tyr Ile Gly Gly Gly Asp Ser 
    290                 295                 300                 

Ser Ser Ser Ser Ser Thr Ser Asn Glu 
305                 310             

<210>   273
<211>   1247
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   spr0057 protein which omits the natural leader peptide and sortase recognition sequences

<400>   273
Ala Asp Gly Val Thr Pro Thr Thr Thr Glu Asn Gln Pro Thr Ile His 
1               5                   10                  15      

Thr Val Ser Asp Ser Pro Gln Ser Ser Glu Asn Arg Thr Glu Glu Thr 
            20                  25                  30          

Pro Lys Ala Glu Leu Gln Pro Glu Ala Pro Lys Thr Val Glu Thr Glu 
        35                  40                  45              

Thr Pro Ala Thr Asp Lys Val Ala Ser Leu Pro Lys Thr Glu Glu Lys 
    50                  55                  60                  

Pro Gln Glu Glu Val Ser Ser Thr Pro Ser Asp Lys Ala Glu Val Val 
65                  70                  75                  80  

Thr Pro Thr Ser Ala Glu Lys Glu Thr Ala Asn Lys Lys Glu Glu Glu 
                85                  90                  95      

Ala Ser Pro Lys Lys Glu Glu Ala Lys Glu Val Asp Ser Lys Glu Ser 
            100                 105                 110         

Asn Thr Asp Lys Thr Asp Lys Asp Lys Pro Ala Lys Lys Asp Glu Ala 
        115                 120                 125             

Lys Ala Glu Ala Asp Lys Pro Glu Thr Glu Thr Gly Lys Glu Arg Ala 
    130                 135                 140                 

Ala Thr Val Asn Glu Lys Leu Ala Lys Lys Lys Ile Val Ser Ile Asp 
145                 150                 155                 160 

Ala Gly Arg Lys Tyr Phe Ser Pro Glu Gln Leu Lys Glu Ile Ile Asp 
                165                 170                 175     

Lys Ala Lys His Tyr Gly Tyr Thr Asp Leu His Leu Leu Val Gly Asn 
            180                 185                 190         

Asp Gly Leu Arg Phe Met Leu Asp Asp Met Ser Ile Thr Ala Asn Gly 
        195                 200                 205             

Lys Thr Tyr Ala Ser Asp Asp Val Lys Arg Ala Ile Glu Lys Gly Thr 
    210                 215                 220                 

Asn Asp Tyr Tyr Asn Asp Pro Asn Gly Asn His Leu Thr Glu Ser Gln 
225                 230                 235                 240 

Met Thr Asp Leu Ile Asn Tyr Ala Lys Asp Lys Gly Ile Gly Leu Ile 
                245                 250                 255     

Pro Thr Val Asn Ser Pro Gly His Met Asp Ala Ile Leu Asn Ala Met 
            260                 265                 270         

Lys Glu Leu Gly Ile Gln Asn Pro Asn Phe Ser Tyr Phe Gly Lys Lys 
        275                 280                 285             

Ser Ala Arg Thr Val Asp Leu Asp Asn Glu Gln Ala Val Ala Phe Thr 
    290                 295                 300                 

Lys Ala Leu Ile Asp Lys Tyr Ala Ala Tyr Phe Ala Lys Lys Thr Glu 
305                 310                 315                 320 

Ile Phe Asn Ile Gly Leu Asp Glu Tyr Ala Asn Asp Ala Thr Asp Ala 
                325                 330                 335     

Lys Gly Trp Ser Val Leu Gln Ala Asp Lys Tyr Tyr Pro Asn Glu Gly 
            340                 345                 350         

Tyr Pro Val Lys Gly Tyr Glu Lys Phe Ile Ala Tyr Ala Asn Asp Leu 
        355                 360                 365             

Ala Arg Ile Val Lys Ser His Gly Leu Lys Pro Met Ala Phe Asn Asp 
    370                 375                 380                 

Gly Ile Tyr Tyr Asn Ser Asp Thr Ser Phe Gly Ser Phe Asp Lys Asp 
385                 390                 395                 400 

Ile Ile Val Ser Met Trp Thr Gly Gly Trp Gly Gly Tyr Asp Val Ala 
                405                 410                 415     

Ser Ser Lys Leu Leu Ala Glu Lys Gly His Gln Ile Leu Asn Thr Asn 
            420                 425                 430         

Asp Ala Trp Cys Tyr Val Leu Gly Arg Asn Ala Asp Gly Gln Gly Trp 
        435                 440                 445             

Tyr Asn Leu Asp Gln Gly Leu Asn Gly Ile Lys Asn Thr Pro Ile Thr 
    450                 455                 460                 

Ser Val Pro Lys Thr Glu Gly Ala Asp Ile Pro Ile Ile Gly Gly Met 
465                 470                 475                 480 

Val Ala Ala Trp Ala Asp Thr Pro Ser Ala Arg Tyr Ser Pro Ser His 
                485                 490                 495     

Leu Phe Lys Leu Met Arg His Phe Ala Asn Ala Asn Ala Glu Tyr Phe 
            500                 505                 510         

Ala Ala Asp Tyr Glu Ser Ala Glu Gln Ala Leu Asn Glu Val Pro Lys 
        515                 520                 525             

Asp Leu Asn Arg Tyr Thr Ala Glu Ser Val Ala Ala Val Lys Glu Ala 
    530                 535                 540                 

Glu Lys Ala Ile Arg Ser Leu Asp Ser Asn Leu Ser Arg Ala Gln Gln 
545                 550                 555                 560 

Asp Thr Ile Asp Gln Ala Ile Ala Lys Leu Gln Glu Thr Val Asn Asn 
                565                 570                 575     

Leu Thr Leu Thr Pro Glu Ala Gln Lys Glu Glu Glu Ala Lys Arg Glu 
            580                 585                 590         

Val Glu Lys Leu Ala Lys Asn Lys Val Ile Ser Ile Asp Ala Gly Arg 
        595                 600                 605             

Lys Tyr Phe Thr Leu Asp Gln Leu Lys Arg Ile Val Asp Lys Ala Ser 
    610                 615                 620                 

Glu Leu Gly Tyr Ser Asp Val His Leu Leu Leu Gly Asn Asp Gly Leu 
625                 630                 635                 640 

Arg Phe Leu Leu Asn Asp Met Thr Ile Thr Ala Asn Gly Lys Thr Tyr 
                645                 650                 655     

Ala Ser Asp Asp Val Lys Lys Ala Ile Ile Glu Gly Thr Lys Ala Tyr 
            660                 665                 670         

Tyr Asp Asp Pro Asn Gly Thr Ala Leu Thr Gln Ala Glu Val Thr Glu 
        675                 680                 685             

Leu Ile Glu Tyr Ala Lys Ser Lys Asp Ile Gly Leu Ile Pro Ala Ile 
    690                 695                 700                 

Asn Ser Pro Gly His Met Asp Ala Met Leu Val Ala Met Glu Lys Leu 
705                 710                 715                 720 

Gly Ile Lys Asn Pro Gln Ala His Phe Asp Lys Val Ser Lys Thr Thr 
                725                 730                 735     

Met Asp Leu Lys Asn Glu Glu Ala Met Asn Phe Val Lys Ala Leu Ile 
            740                 745                 750         

Gly Lys Tyr Met Asp Phe Phe Ala Gly Lys Thr Lys Ile Phe Asn Phe 
        755                 760                 765             

Gly Thr Asp Glu Tyr Ala Asn Asp Ala Thr Ser Ala Gln Gly Trp Tyr 
    770                 775                 780                 

Tyr Leu Lys Trp Tyr Gln Leu Tyr Gly Lys Phe Ala Glu Tyr Ala Asn 
785                 790                 795                 800 

Thr Leu Ala Ala Met Ala Lys Glu Arg Gly Leu Gln Pro Met Ala Phe 
                805                 810                 815     

Asn Asp Gly Phe Tyr Tyr Glu Asp Lys Asp Asp Val Gln Phe Asp Lys 
            820                 825                 830         

Asp Val Leu Ile Ser Tyr Trp Ser Lys Gly Trp Trp Gly Tyr Asn Leu 
        835                 840                 845             

Ala Ser Pro Gln Tyr Leu Ala Ser Lys Gly Tyr Lys Phe Leu Asn Thr 
    850                 855                 860                 

Asn Gly Asp Trp Tyr Tyr Val Ile Gly Asn His Lys Gln Asp Glu Ala 
865                 870                 875                 880 

Tyr Pro Leu Ser Lys Ala Val Glu Asn Ser Gly Lys Val Pro Phe Asn 
                885                 890                 895     

Gln Leu Ala Ser Thr Lys Tyr Pro Glu Val Asp Leu Pro Thr Val Gly 
            900                 905                 910         

Ser Met Leu Ser Ile Trp Ala Asp Arg Pro Ser Ala Glu Tyr Lys Glu 
        915                 920                 925             

Glu Glu Ile Phe Glu Leu Met Thr Ala Phe Ala Asp His Asn Lys Asp 
    930                 935                 940                 

Tyr Phe Arg Ala Asn Tyr Asn Ala Leu Arg Glu Glu Leu Ala Lys Ile 
945                 950                 955                 960 

Pro Thr Asn Leu Glu Gly Tyr Ser Lys Glu Ser Leu Glu Ala Leu Asp 
                965                 970                 975     

Ala Ala Lys Thr Ala Leu Asn Tyr Asn Leu Asn Arg Asn Lys Gln Ala 
            980                 985                 990         

Glu Leu Asp Thr Leu Val Ala Asn Leu Lys Ala Ala Leu Gln Gly Leu 
        995                 1000                1005            

Lys Pro Ala Ala Thr His Ser Gly Ser Leu Asp Glu Asn Glu Val Ala 
    1010                1015                1020                

Ala Asn Val Glu Thr Arg Pro Glu Leu Ile Thr Arg Thr Glu Glu Ile 
1025                1030                1035                1040

Pro Phe Glu Val Ile Lys Lys Glu Asn Pro Asn Leu Pro Ala Gly Gln 
                1045                1050                1055    

Glu Asn Ile Ile Thr Ala Gly Val Lys Gly Glu Arg Thr His Tyr Ile 
            1060                1065                1070        

Ser Val Leu Thr Glu Asn Gly Lys Thr Thr Glu Thr Val Leu Asp Ser 
        1075                1080                1085            

Gln Val Thr Lys Glu Val Ile Asn Gln Val Val Glu Val Gly Ser Pro 
    1090                1095                1100                

Val Thr His Lys Gly Asp Glu Ser Gly Leu Ala Pro Thr Thr Glu Val 
1105                1110                1115                1120

Lys Pro Arg Leu Asp Ile Gln Glu Glu Glu Ile Pro Phe Thr Thr Val 
                1125                1130                1135    

Thr Arg Glu Asn Pro Leu Leu Leu Lys Gly Lys Thr Gln Val Ile Thr 
            1140                1145                1150        

Lys Gly Val Asn Gly His Arg Ser Asn Phe Tyr Ser Val Ser Thr Ser 
        1155                1160                1165            

Ala Asp Gly Lys Glu Val Lys Thr Leu Val Asn Ser Val Val Ala Gln 
    1170                1175                1180                

Glu Ala Val Thr Gln Ile Val Glu Val Gly Thr Met Val Thr His Val 
1185                1190                1195                1200

Gly Asp Glu Asn Gly Gln Ala Ala Ile Ala Glu Glu Lys Pro Lys Leu 
                1205                1210                1215    

Glu Ile Pro Ser Gln Pro Ala Pro Ser Thr Ala Pro Ala Glu Glu Ser 
            1220                1225                1230        

Lys Ala Leu Pro Gln Asp Pro Ala Pro Val Val Thr Glu Lys Lys 
        1235                1240                1245        

<210>   274
<211>   1008
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   spr0286

<400>   274
Gly Ala Glu Glu Thr Thr Thr Asn Thr Ile Gln Gln Ser Gln Lys Glu 
1               5                   10                  15      

Val Gln Tyr Gln Gln Arg Asp Thr Lys Asn Leu Val Glu Asn Gly Asp 
            20                  25                  30          

Phe Gly Gln Thr Glu Asp Gly Ser Ser Pro Trp Thr Gly Ser Lys Ala 
        35                  40                  45              

Gln Gly Trp Ser Ala Trp Val Asp Gln Lys Asn Ser Ser Ala Asp Ala 
    50                  55                  60                  

Ser Thr Arg Val Ile Glu Ala Lys Asp Gly Ala Ile Thr Ile Ser Ser 
65                  70                  75                  80  

Pro Glu Lys Leu Arg Ala Ala Val His Arg Met Val Pro Ile Glu Ala 
                85                  90                  95      

Lys Lys Lys Tyr Lys Leu Arg Phe Lys Ile Lys Thr Asp Asn Lys Val 
            100                 105                 110         

Gly Ile Ala Lys Val Arg Ile Ile Glu Glu Ser Gly Lys Asp Lys Arg 
        115                 120                 125             

Leu Trp Asn Ser Ala Thr Thr Ser Gly Thr Lys Asp Trp Gln Thr Ile 
    130                 135                 140                 

Glu Ala Asp Tyr Ser Pro Thr Leu Asp Val Asp Lys Ile Lys Leu Glu 
145                 150                 155                 160 

Leu Phe Tyr Glu Thr Gly Thr Gly Thr Val Ser Phe Lys Asp Ile Glu 
                165                 170                 175     

Leu Val Glu Val Ala Asp Gln Pro Ser Glu Asp Ser Gln Thr Asp Lys 
            180                 185                 190         

Gln Leu Glu Glu Lys Ile Asp Leu Pro Ile Gly Lys Lys His Val Phe 
        195                 200                 205             

Ser Leu Ala Asp Tyr Thr Tyr Lys Val Glu Asn Pro Asp Val Ala Ser 
    210                 215                 220                 

Val Lys Asn Gly Ile Leu Glu Pro Leu Lys Glu Gly Thr Thr Asn Val 
225                 230                 235                 240 

Ile Val Ser Lys Asp Gly Lys Glu Val Lys Lys Ile Pro Leu Lys Ile 
                245                 250                 255     

Leu Ala Ser Val Lys Asp Thr Tyr Thr Asp Arg Leu Asp Asp Trp Asn 
            260                 265                 270         

Gly Ile Ile Ala Gly Asn Gln Tyr Tyr Asp Ser Lys Asn Glu Gln Met 
        275                 280                 285             

Ala Lys Leu Asn Gln Glu Leu Glu Gly Lys Val Ala Asp Ser Leu Ser 
    290                 295                 300                 

Ser Ile Ser Ser Gln Ala Asp Arg Ile Tyr Leu Trp Glu Lys Phe Ser 
305                 310                 315                 320 

Asn Tyr Lys Thr Ser Ala Asn Leu Thr Ala Thr Tyr Arg Lys Leu Glu 
                325                 330                 335     

Glu Met Ala Lys Gln Val Thr Asn Pro Ser Ser Arg Tyr Tyr Gln Asp 
            340                 345                 350         

Glu Thr Val Val Arg Thr Val Arg Asp Ser Met Glu Trp Met His Lys 
        355                 360                 365             

His Val Tyr Asn Ser Glu Lys Ser Ile Val Gly Asn Trp Trp Asp Tyr 
    370                 375                 380                 

Glu Ile Gly Thr Pro Arg Ala Ile Asn Asn Thr Leu Ser Leu Met Lys 
385                 390                 395                 400 

Glu Tyr Phe Ser Asp Glu Glu Ile Lys Lys Tyr Thr Asp Val Ile Glu 
                405                 410                 415     

Lys Phe Val Pro Asp Pro Glu His Phe Arg Lys Thr Thr Asp Asn Pro 
            420                 425                 430         

Phe Lys Ala Leu Gly Gly Asn Leu Val Asp Met Gly Arg Val Lys Val 
        435                 440                 445             

Ile Ala Gly Leu Leu Arg Lys Asp Asp Gln Glu Ile Ser Ser Thr Ile 
    450                 455                 460                 

Arg Ser Ile Glu Gln Val Phe Lys Leu Val Asp Gln Gly Glu Gly Phe 
465                 470                 475                 480 

Tyr Gln Asp Gly Ser Tyr Ile Asp His Thr Asn Val Ala Tyr Thr Gly 
                485                 490                 495     

Ala Tyr Gly Asn Val Leu Ile Asp Gly Leu Ser Gln Leu Leu Pro Val 
            500                 505                 510         

Ile Gln Lys Thr Lys Asn Pro Ile Asp Lys Asp Lys Met Gln Thr Met 
        515                 520                 525             

Tyr His Trp Ile Asp Lys Ser Phe Ala Pro Leu Leu Val Asn Gly Glu 
    530                 535                 540                 

Leu Met Asp Met Ser Arg Gly Arg Ser Ile Ser Arg Ala Asn Ser Glu 
545                 550                 555                 560 

Gly His Val Ala Ala Val Glu Val Leu Arg Gly Ile His Arg Ile Ala 
                565                 570                 575     

Asp Met Ser Glu Gly Glu Thr Lys Gln Arg Leu Gln Ser Leu Val Lys 
            580                 585                 590         

Thr Ile Val Gln Ser Asp Ser Tyr Tyr Asp Val Phe Lys Asn Leu Lys 
        595                 600                 605             

Thr Tyr Lys Asp Ile Ser Leu Met Gln Ser Leu Leu Ser Asp Ala Gly 
    610                 615                 620                 

Val Ala Ser Val Pro Arg Thr Ser Tyr Leu Ser Ala Phe Asn Lys Met 
625                 630                 635                 640 

Asp Lys Thr Ala Met Tyr Asn Ala Glu Lys Gly Phe Gly Phe Gly Leu 
                645                 650                 655     

Ser Leu Phe Ser Ser Arg Thr Leu Asn Tyr Glu His Met Asn Lys Glu 
            660                 665                 670         

Asn Lys Arg Gly Trp Tyr Thr Ser Asp Gly Met Phe Tyr Leu Tyr Asn 
        675                 680                 685             

Gly Asp Leu Ser His Tyr Ser Asp Gly Tyr Trp Pro Thr Val Asn Pro 
    690                 695                 700                 

Tyr Lys Met Pro Gly Thr Thr Glu Thr Asp Ala Lys Arg Ala Asp Ser 
705                 710                 715                 720 

Asp Thr Gly Lys Val Leu Pro Ser Ala Phe Val Gly Thr Ser Lys Leu 
                725                 730                 735     

Asp Asp Ala Asn Ala Thr Ala Thr Met Asp Phe Thr Asn Trp Asn Gln 
            740                 745                 750         

Thr Leu Thr Ala His Lys Ser Trp Phe Met Leu Lys Asp Lys Ile Ala 
        755                 760                 765             

Phe Leu Gly Ser Asn Ile Gln Asn Thr Ser Thr Asp Thr Ala Ala Thr 
    770                 775                 780                 

Thr Ile Asp Gln Arg Lys Leu Glu Ser Ser Asn Pro Tyr Lys Val Tyr 
785                 790                 795                 800 

Val Asn Asp Lys Glu Ala Ser Leu Thr Glu Gln Glu Lys Asp Tyr Pro 
                805                 810                 815     

Glu Thr Gln Ser Val Phe Leu Glu Ser Ser Asp Ser Lys Lys Asn Ile 
            820                 825                 830         

Gly Tyr Phe Phe Phe Lys Lys Ser Ser Ile Ser Met Ser Lys Ala Leu 
        835                 840                 845             

Gln Lys Gly Ala Trp Lys Asp Ile Asn Glu Gly Gln Ser Asp Lys Glu 
    850                 855                 860                 

Val Glu Asn Glu Phe Leu Thr Ile Ser Gln Ala His Lys Gln Asn Gly 
865                 870                 875                 880 

Asp Ser Tyr Gly Tyr Met Leu Ile Pro Asn Val Asp Arg Ala Thr Phe 
                885                 890                 895     

Asn Gln Met Ile Lys Glu Leu Glu Ser Ser Leu Ile Glu Asn Asn Glu 
            900                 905                 910         

Thr Leu Gln Ser Val Tyr Asp Ala Lys Gln Gly Val Trp Gly Ile Val 
        915                 920                 925             

Lys Tyr Asp Asp Ser Val Ser Thr Ile Ser Asn Gln Phe Gln Val Leu 
    930                 935                 940                 

Lys Arg Gly Val Tyr Thr Ile Arg Lys Glu Gly Asp Glu Tyr Lys Ile 
945                 950                 955                 960 

Ala Tyr Tyr Asn Pro Glu Thr Gln Glu Ser Ala Pro Asp Gln Glu Val 
                965                 970                 975     

Phe Lys Lys Leu Glu Gln Ala Ala Gln Pro Gln Val Gln Asn Ser Lys 
            980                 985                 990         

Glu Lys Glu Lys Ser Glu Glu Glu Lys Asn His Ser Asp Gln Lys Asn 
        995                 1000                1005            


<210>   275
<211>   628
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   spr0286 fragment

<400>   275
Gly Ala Glu Glu Thr Thr Thr Asn Thr Ile Gln Gln Ser Gln Lys Glu 
1               5                   10                  15      

Val Gln Tyr Gln Gln Arg Asp Thr Lys Asn Leu Val Glu Asn Gly Asp 
            20                  25                  30          

Phe Gly Gln Thr Glu Asp Gly Ser Ser Pro Trp Thr Gly Ser Lys Ala 
        35                  40                  45              

Gln Gly Trp Ser Ala Trp Val Asp Gln Lys Asn Ser Ser Ala Asp Ala 
    50                  55                  60                  

Ser Thr Arg Val Ile Glu Ala Lys Asp Gly Ala Ile Thr Ile Ser Ser 
65                  70                  75                  80  

Pro Glu Lys Leu Arg Ala Ala Val His Arg Met Val Pro Ile Glu Ala 
                85                  90                  95      

Lys Lys Lys Tyr Lys Leu Arg Phe Lys Ile Lys Thr Asp Asn Lys Val 
            100                 105                 110         

Gly Ile Ala Lys Val Arg Ile Ile Glu Glu Ser Gly Lys Asp Lys Arg 
        115                 120                 125             

Leu Trp Asn Ser Ala Thr Thr Ser Gly Thr Lys Asp Trp Gln Thr Ile 
    130                 135                 140                 

Glu Ala Asp Tyr Ser Pro Thr Leu Asp Val Asp Lys Ile Lys Leu Glu 
145                 150                 155                 160 

Leu Phe Tyr Glu Thr Gly Thr Gly Thr Val Ser Phe Lys Asp Ile Glu 
                165                 170                 175     

Leu Val Glu Val Ala Asp Gln Pro Ser Glu Asp Ser Gln Thr Asp Lys 
            180                 185                 190         

Gln Leu Glu Glu Lys Ile Asp Leu Pro Ile Gly Lys Lys His Val Phe 
        195                 200                 205             

Ser Leu Ala Asp Tyr Thr Tyr Lys Val Glu Asn Pro Asp Val Ala Ser 
    210                 215                 220                 

Val Lys Asn Gly Ile Leu Glu Pro Leu Lys Glu Gly Thr Thr Asn Val 
225                 230                 235                 240 

Ile Val Ser Lys Asp Gly Lys Glu Val Lys Lys Ile Pro Leu Lys Ile 
                245                 250                 255     

Leu Ala Ser Val Lys Asp Thr Tyr Thr Asp Arg Leu Asp Asp Trp Asn 
            260                 265                 270         

Gly Ile Ile Ala Gly Asn Gln Tyr Tyr Asp Ser Lys Asn Glu Gln Met 
        275                 280                 285             

Ala Lys Leu Asn Gln Glu Leu Glu Gly Lys Val Ala Asp Ser Leu Ser 
    290                 295                 300                 

Ser Ile Ser Ser Gln Ala Asp Arg Ile Tyr Leu Trp Glu Lys Phe Ser 
305                 310                 315                 320 

Asn Tyr Lys Thr Ser Ala Asn Leu Thr Ala Thr Tyr Arg Lys Leu Glu 
                325                 330                 335     

Glu Met Ala Lys Gln Val Thr Asn Pro Ser Ser Arg Tyr Tyr Gln Asp 
            340                 345                 350         

Glu Thr Val Val Arg Thr Val Arg Asp Ser Met Glu Trp Met His Lys 
        355                 360                 365             

His Val Tyr Asn Ser Glu Lys Ser Ile Val Gly Asn Trp Trp Asp Tyr 
    370                 375                 380                 

Glu Ile Gly Thr Pro Arg Ala Ile Asn Asn Thr Leu Ser Leu Met Lys 
385                 390                 395                 400 

Glu Tyr Phe Ser Asp Glu Glu Ile Lys Lys Tyr Thr Asp Val Ile Glu 
                405                 410                 415     

Lys Phe Val Pro Asp Pro Glu His Phe Arg Lys Thr Thr Asp Asn Pro 
            420                 425                 430         

Phe Lys Ala Leu Gly Gly Asn Leu Val Asp Met Gly Arg Val Lys Val 
        435                 440                 445             

Ile Ala Gly Leu Leu Arg Lys Asp Asp Gln Glu Ile Ser Ser Thr Ile 
    450                 455                 460                 

Arg Ser Ile Glu Gln Val Phe Lys Leu Val Asp Gln Gly Glu Gly Phe 
465                 470                 475                 480 

Tyr Gln Asp Gly Ser Tyr Ile Asp His Thr Asn Val Ala Tyr Thr Gly 
                485                 490                 495     

Ala Tyr Gly Asn Val Leu Ile Asp Gly Leu Ser Gln Leu Leu Pro Val 
            500                 505                 510         

Ile Gln Lys Thr Lys Asn Pro Ile Asp Lys Asp Lys Met Gln Thr Met 
        515                 520                 525             

Tyr His Trp Ile Asp Lys Ser Phe Ala Pro Leu Leu Val Asn Gly Glu 
    530                 535                 540                 

Leu Met Asp Met Ser Arg Gly Arg Ser Ile Ser Arg Ala Asn Ser Glu 
545                 550                 555                 560 

Gly His Val Ala Ala Val Glu Val Leu Arg Gly Ile His Arg Ile Ala 
                565                 570                 575     

Asp Met Ser Glu Gly Glu Thr Lys Gln Arg Leu Gln Ser Leu Val Lys 
            580                 585                 590         

Thr Ile Val Gln Ser Asp Ser Tyr Tyr Asp Val Phe Lys Asn Leu Lys 
        595                 600                 605             

Thr Tyr Lys Asp Ile Ser Leu Met Gln Ser Leu Leu Ser Asp Ala Gly 
    610                 615                 620                 

Val Ala Ser Val 
625             

<210>   276
<211>   452
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   spr0286 fragment

<400>   276
Ala Asn Ser Glu Gly His Val Ala Ala Val Glu Val Leu Arg Gly Ile 
1               5                   10                  15      

His Arg Ile Ala Asp Met Ser Glu Gly Glu Thr Lys Gln Arg Leu Gln 
            20                  25                  30          

Ser Leu Val Lys Thr Ile Val Gln Ser Asp Ser Tyr Tyr Asp Val Phe 
        35                  40                  45              

Lys Asn Leu Lys Thr Tyr Lys Asp Ile Ser Leu Met Gln Ser Leu Leu 
    50                  55                  60                  

Ser Asp Ala Gly Val Ala Ser Val Pro Arg Thr Ser Tyr Leu Ser Ala 
65                  70                  75                  80  

Phe Asn Lys Met Asp Lys Thr Ala Met Tyr Asn Ala Glu Lys Gly Phe 
                85                  90                  95      

Gly Phe Gly Leu Ser Leu Phe Ser Ser Arg Thr Leu Asn Tyr Glu His 
            100                 105                 110         

Met Asn Lys Glu Asn Lys Arg Gly Trp Tyr Thr Ser Asp Gly Met Phe 
        115                 120                 125             

Tyr Leu Tyr Asn Gly Asp Leu Ser His Tyr Ser Asp Gly Tyr Trp Pro 
    130                 135                 140                 

Thr Val Asn Pro Tyr Lys Met Pro Gly Thr Thr Glu Thr Asp Ala Lys 
145                 150                 155                 160 

Arg Ala Asp Ser Asp Thr Gly Lys Val Leu Pro Ser Ala Phe Val Gly 
                165                 170                 175     

Thr Ser Lys Leu Asp Asp Ala Asn Ala Thr Ala Thr Met Asp Phe Thr 
            180                 185                 190         

Asn Trp Asn Gln Thr Leu Thr Ala His Lys Ser Trp Phe Met Leu Lys 
        195                 200                 205             

Asp Lys Ile Ala Phe Leu Gly Ser Asn Ile Gln Asn Thr Ser Thr Asp 
    210                 215                 220                 

Thr Ala Ala Thr Thr Ile Asp Gln Arg Lys Leu Glu Ser Ser Asn Pro 
225                 230                 235                 240 

Tyr Lys Val Tyr Val Asn Asp Lys Glu Ala Ser Leu Thr Glu Gln Glu 
                245                 250                 255     

Lys Asp Tyr Pro Glu Thr Gln Ser Val Phe Leu Glu Ser Ser Asp Ser 
            260                 265                 270         

Lys Lys Asn Ile Gly Tyr Phe Phe Phe Lys Lys Ser Ser Ile Ser Met 
        275                 280                 285             

Ser Lys Ala Leu Gln Lys Gly Ala Trp Lys Asp Ile Asn Glu Gly Gln 
    290                 295                 300                 

Ser Asp Lys Glu Val Glu Asn Glu Phe Leu Thr Ile Ser Gln Ala His 
305                 310                 315                 320 

Lys Gln Asn Gly Asp Ser Tyr Gly Tyr Met Leu Ile Pro Asn Val Asp 
                325                 330                 335     

Arg Ala Thr Phe Asn Gln Met Ile Lys Glu Leu Glu Ser Ser Leu Ile 
            340                 345                 350         

Glu Asn Asn Glu Thr Leu Gln Ser Val Tyr Asp Ala Lys Gln Gly Val 
        355                 360                 365             

Trp Gly Ile Val Lys Tyr Asp Asp Ser Val Ser Thr Ile Ser Asn Gln 
    370                 375                 380                 

Phe Gln Val Leu Lys Arg Gly Val Tyr Thr Ile Arg Lys Glu Gly Asp 
385                 390                 395                 400 

Glu Tyr Lys Ile Ala Tyr Tyr Asn Pro Glu Thr Gln Glu Ser Ala Pro 
                405                 410                 415     

Asp Gln Glu Val Phe Lys Lys Leu Glu Gln Ala Ala Gln Pro Gln Val 
            420                 425                 430         

Gln Asn Ser Lys Glu Lys Glu Lys Ser Glu Glu Glu Lys Asn His Ser 
        435                 440                 445             

Asp Gln Lys Asn 
    450         

<210>   277
<211>   2148
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   spr0565 protein, which omits the natural leader peptide and sortase recognition sequences

<400>   277
Asp Glu Thr Leu Ile Thr His Thr Ala Glu Lys Pro Lys Glu Glu Lys 
1               5                   10                  15      

Met Ile Val Glu Glu Lys Ala Asp Lys Ala Leu Glu Thr Lys Asn Val 
            20                  25                  30          

Val Glu Arg Thr Glu Gln Ser Glu Pro Ser Ser Thr Glu Ala Ile Ala 
        35                  40                  45              

Ser Glu Lys Lys Glu Asp Glu Ala Val Thr Pro Lys Glu Glu Lys Val 
    50                  55                  60                  

Ser Ala Lys Pro Glu Glu Lys Ala Pro Arg Ile Glu Ser Gln Ala Ser 
65                  70                  75                  80  

Ser Gln Glu Lys Pro Leu Lys Glu Asp Ala Lys Ala Val Thr Asn Glu 
                85                  90                  95      

Glu Val Asn Gln Met Ile Glu Asn Arg Lys Val Asp Phe Asn Gln Asn 
            100                 105                 110         

Trp Tyr Phe Lys Leu Asn Ala Asn Ser Lys Glu Ala Ile Lys Pro Asp 
        115                 120                 125             

Ala Asp Val Ser Thr Trp Lys Lys Leu Asp Leu Pro Tyr Asp Trp Ser 
    130                 135                 140                 

Ile Phe Asn Asp Phe Asp His Glu Ser Pro Ala Gln Asn Glu Gly Gly 
145                 150                 155                 160 

Gln Leu Asn Gly Gly Glu Ala Trp Tyr Arg Lys Thr Phe Lys Leu Asp 
                165                 170                 175     

Glu Lys Asp Leu Lys Lys Asn Val Arg Leu Thr Phe Asp Gly Val Tyr 
            180                 185                 190         

Met Asp Ser Gln Val Tyr Val Asn Gly Gln Leu Val Gly His Tyr Pro 
        195                 200                 205             

Asn Gly Tyr Asn Gln Phe Ser Tyr Asp Ile Thr Lys Tyr Leu Tyr Lys 
    210                 215                 220                 

Asp Gly Arg Glu Asn Val Ile Ala Val His Ala Val Asn Lys Gln Pro 
225                 230                 235                 240 

Ser Ser Arg Trp Tyr Ser Gly Ser Gly Ile Tyr Arg Asp Val Thr Leu 
                245                 250                 255     

Gln Val Thr Asp Lys Val His Val Glu Lys Asn Gly Thr Thr Ile Leu 
            260                 265                 270         

Thr Pro Lys Leu Glu Glu Gln Gln His Gly Lys Val Glu Thr His Val 
        275                 280                 285             

Thr Ser Lys Ile Val Asn Thr Asp Asp Lys Asp His Glu Leu Val Ala 
    290                 295                 300                 

Glu Tyr Gln Ile Val Glu Arg Gly Gly His Ala Val Thr Gly Leu Val 
305                 310                 315                 320 

Arg Thr Ala Ser Arg Thr Leu Lys Ala His Glu Ser Thr Ser Leu Asp 
                325                 330                 335     

Ala Ile Leu Glu Val Glu Arg Pro Lys Leu Trp Thr Val Leu Asn Asp 
            340                 345                 350         

Lys Pro Ala Leu Tyr Glu Leu Ile Thr Arg Val Tyr Arg Asp Gly Gln 
        355                 360                 365             

Leu Val Asp Ala Lys Lys Asp Leu Phe Gly Tyr Arg Tyr Tyr His Trp 
    370                 375                 380                 

Thr Pro Asn Glu Gly Phe Ser Leu Asn Gly Glu Arg Ile Lys Phe His 
385                 390                 395                 400 

Gly Val Ser Leu His His Asp His Gly Ala Leu Gly Ala Glu Glu Asn 
                405                 410                 415     

Tyr Lys Ala Glu Tyr Arg Arg Leu Lys Gln Met Lys Glu Met Gly Val 
            420                 425                 430         

Asn Ser Ile Arg Thr Thr His Asn Pro Ala Ser Glu Gln Thr Leu Gln 
        435                 440                 445             

Ile Ala Ala Glu Leu Gly Leu Leu Val Gln Glu Glu Ala Phe Asp Thr 
    450                 455                 460                 

Trp Tyr Gly Gly Lys Lys Pro Tyr Asp Tyr Gly Arg Phe Phe Glu Lys 
465                 470                 475                 480 

Asp Ala Thr His Pro Glu Ala Arg Lys Gly Glu Lys Trp Ser Asp Phe 
                485                 490                 495     

Asp Leu Arg Thr Met Val Glu Arg Gly Lys Asn Asn Pro Ala Ile Phe 
            500                 505                 510         

Met Trp Ser Ile Gly Asn Glu Ile Gly Glu Ala Asn Gly Asp Ala His 
        515                 520                 525             

Ser Leu Ala Thr Val Lys Arg Leu Val Lys Val Ile Lys Asp Val Asp 
    530                 535                 540                 

Lys Thr Arg Tyr Val Thr Met Gly Ala Asp Lys Phe Arg Phe Gly Asn 
545                 550                 555                 560 

Gly Ser Gly Gly His Glu Lys Ile Ala Asp Glu Leu Asp Ala Val Gly 
                565                 570                 575     

Phe Asn Tyr Ser Glu Asp Asn Tyr Lys Ala Leu Arg Ala Lys His Pro 
            580                 585                 590         

Lys Trp Leu Ile Tyr Gly Ser Glu Thr Ser Ser Ala Thr Arg Thr Arg 
        595                 600                 605             

Gly Ser Tyr Tyr Arg Pro Glu Arg Glu Leu Lys His Ser Asn Gly Pro 
    610                 615                 620                 

Glu Arg Asn Tyr Glu Gln Ser Asp Tyr Gly Asn Asp Arg Val Gly Trp 
625                 630                 635                 640 

Gly Lys Thr Ala Thr Ala Ser Trp Thr Phe Asp Arg Asp Asn Ala Gly 
                645                 650                 655     

Tyr Ala Gly Gln Phe Ile Trp Thr Gly Thr Asp Tyr Ile Gly Glu Pro 
            660                 665                 670         

Thr Pro Trp His Asn Gln Asn Gln Thr Pro Val Lys Ser Ser Tyr Phe 
        675                 680                 685             

Gly Ile Val Asp Thr Ala Gly Ile Pro Lys His Asp Phe Tyr Leu Tyr 
    690                 695                 700                 

Gln Ser Gln Trp Val Ser Val Lys Lys Lys Pro Met Val His Leu Leu 
705                 710                 715                 720 

Pro His Trp Asn Trp Glu Asn Lys Glu Leu Ala Ser Lys Val Ala Asp 
                725                 730                 735     

Ser Glu Gly Lys Ile Pro Val Arg Ala Tyr Ser Asn Ala Ser Ser Val 
            740                 745                 750         

Glu Leu Phe Leu Asn Gly Lys Ser Leu Gly Leu Lys Thr Phe Asn Lys 
        755                 760                 765             

Lys Gln Thr Ser Asp Gly Arg Thr Tyr Gln Glu Gly Ala Asn Ala Asn 
    770                 775                 780                 

Glu Leu Tyr Leu Glu Trp Lys Val Ala Tyr Gln Pro Gly Thr Leu Glu 
785                 790                 795                 800 

Ala Ile Ala Arg Asp Glu Ser Gly Lys Glu Ile Ala Arg Asp Lys Ile 
                805                 810                 815     

Thr Thr Ala Gly Lys Pro Ala Ala Val Arg Leu Ile Lys Glu Asp His 
            820                 825                 830         

Ala Ile Ala Ala Asp Gly Lys Asp Leu Thr Tyr Ile Tyr Tyr Glu Ile 
        835                 840                 845             

Val Asp Ser Gln Gly Asn Val Val Pro Thr Ala Asn Asn Leu Val Arg 
    850                 855                 860                 

Phe Gln Leu His Gly Gln Gly Gln Leu Val Gly Val Asp Asn Gly Glu 
865                 870                 875                 880 

Gln Ala Ser Arg Glu Arg Tyr Lys Ala Gln Ala Asp Gly Ser Trp Ile 
                885                 890                 895     

Arg Lys Ala Phe Asn Gly Lys Gly Val Ala Ile Val Lys Ser Thr Glu 
            900                 905                 910         

Gln Ala Gly Lys Phe Thr Leu Thr Ala His Ser Asp Leu Leu Lys Ser 
        915                 920                 925             

Asn Gln Val Thr Val Phe Thr Gly Lys Lys Glu Gly Gln Glu Lys Thr 
    930                 935                 940                 

Val Leu Gly Thr Glu Val Pro Lys Val Gln Thr Ile Ile Gly Glu Ala 
945                 950                 955                 960 

Pro Glu Met Pro Thr Thr Val Pro Phe Val Tyr Ser Asp Gly Ser Arg 
                965                 970                 975     

Ala Glu Arg Pro Val Thr Trp Ser Leu Val Asp Val Ser Lys Pro Gly 
            980                 985                 990         

Ile Val Thr Val Lys Gly Met Ala Asp Gly Arg Glu Val Glu Ala Arg 
        995                 1000                1005            

Val Glu Val Ile Ala Leu Lys Ser Glu Leu Pro Val Val Lys Arg Ile 
    1010                1015                1020                

Ala Pro Asn Thr Asn Leu Asn Ser Val Asp Lys Ser Val Ser Tyr Val 
1025                1030                1035                1040

Leu Thr Asp Gly Ser Val Gln Glu Tyr Glu Val Asp Lys Trp Glu Ile 
                1045                1050                1055    

Ala Glu Glu Asp Lys Ala Lys Leu Ala Ile Pro Gly Ser Arg Ile Gln 
            1060                1065                1070        

Ala Thr Gly Tyr Leu Glu Gly Gln Pro Ile His Ala Thr Leu Val Val 
        1075                1080                1085            

Glu Glu Gly Asn Pro Ala Ala Pro Val Val Pro Thr Val Thr Val Gly 
    1090                1095                1100                

Gly Glu Ala Val Thr Gly Leu Thr Ser Arg Gln Pro Met Gln Tyr Arg 
1105                1110                1115                1120

Thr Leu Ser Tyr Gly Ala Gln Leu Pro Glu Val Thr Ala Ser Ala Glu 
                1125                1130                1135    

Asn Ala Asp Val Thr Val Leu Gln Ala Ser Ala Ala Asn Gly Met Arg 
            1140                1145                1150        

Ala Ser Ile Phe Ile Gln Pro Lys Asp Gly Gly Pro Leu Gln Thr Tyr 
        1155                1160                1165            

Ala Ile Gln Phe Leu Glu Glu Ala Pro Lys Ile Ala His Leu Ser Leu 
    1170                1175                1180                

Gln Val Glu Lys Ala Asp Ser Leu Lys Glu Asp Gln Thr Val Lys Leu 
1185                1190                1195                1200

Ser Val Arg Ala His Tyr Gln Asp Gly Thr Gln Ala Val Leu Pro Ala 
                1205                1210                1215    

Asp Lys Val Thr Phe Ser Thr Ser Gly Glu Gly Glu Val Ala Ile Arg 
            1220                1225                1230        

Lys Gly Met Leu Glu Leu His Lys Pro Gly Ala Val Thr Leu Asn Ala 
        1235                1240                1245            

Glu Tyr Glu Gly Ala Lys Gly Gln Val Glu Leu Thr Ile Gln Ala Asn 
    1250                1255                1260                

Thr Glu Lys Lys Ile Ala Gln Ser Ile Arg Pro Val Asn Val Val Thr 
1265                1270                1275                1280

Asp Leu His Gln Glu Pro Ser Leu Pro Ala Thr Val Thr Val Glu Tyr 
                1285                1290                1295    

Asp Lys Gly Phe Pro Lys Thr His Lys Val Thr Trp Gln Ala Ile Pro 
            1300                1305                1310        

Lys Glu Lys Leu Asp Ser Tyr Gln Ile Phe Glu Val Leu Gly Lys Val 
        1315                1320                1325            

Glu Gly Ile Asp Leu Glu Ala Arg Ala Lys Val Ser Val Glu Gly Ile 
    1330                1335                1340                

Val Ser Val Glu Glu Val Ser Val Thr Thr Pro Ile Ala Glu Ala Pro 
1345                1350                1355                1360

Gln Leu Pro Glu Ser Val Arg Thr Tyr Asp Ser Asn Gly His Val Ser 
                1365                1370                1375    

Ser Ala Lys Val Ala Trp Asp Ala Ile Arg Pro Glu Gln Tyr Ala Lys 
            1380                1385                1390        

Glu Gly Val Phe Thr Val Asn Gly Arg Leu Glu Gly Thr Gln Leu Thr 
        1395                1400                1405            

Thr Lys Leu His Val Arg Val Ser Ala Gln Thr Glu Gln Gly Ala Asn 
    1410                1415                1420                

Ile Ser Asp Gln Trp Thr Gly Ser Glu Leu Pro Leu Ala Phe Ala Ser 
1425                1430                1435                1440

Asp Ser Asn Pro Ser Asp Pro Val Ser Asn Val Asn Asp Lys Leu Ile 
                1445                1450                1455    

Ser Tyr Asn Asn Gln Pro Ala Asn Arg Trp Thr Asn Trp Asn Arg Ser 
            1460                1465                1470        

Asn Pro Glu Ala Ser Val Gly Val Leu Phe Gly Asp Ser Gly Ile Leu 
        1475                1480                1485            

Ser Lys Arg Ser Val Asp Asn Leu Ser Val Gly Phe His Glu Asp His 
    1490                1495                1500                

Gly Val Gly Ala Pro Lys Ser Tyr Val Ile Glu Tyr Tyr Val Gly Lys 
1505                1510                1515                1520

Thr Val Pro Thr Ala Pro Lys Asn Pro Ser Phe Val Gly Asn Glu Asp 
                1525                1530                1535    

His Val Phe Asn Asp Ser Ala Asn Trp Lys Pro Val Thr Asn Leu Lys 
            1540                1545                1550        

Ala Pro Ala Gln Leu Lys Ala Gly Glu Met Asn His Phe Ser Phe Asp 
        1555                1560                1565            

Lys Val Glu Thr Tyr Ala Ile Arg Ile Arg Met Val Lys Ala Asp Asn 
    1570                1575                1580                

Lys Arg Gly Thr Ser Ile Thr Glu Val Gln Ile Phe Ala Lys Gln Val 
1585                1590                1595                1600

Ala Ala Ala Lys Gln Gly Gln Thr Arg Ile Gln Val Asp Gly Lys Asp 
                1605                1610                1615    

Leu Ala Asn Phe Asn Pro Asp Leu Thr Asp Tyr Tyr Leu Glu Ser Val 
            1620                1625                1630        

Asp Gly Lys Val Pro Ala Val Thr Ala Asn Val Ser Asn Asn Gly Leu 
        1635                1640                1645            

Ala Thr Val Val Pro Ser Val Arg Glu Gly Glu Pro Val Arg Val Ile 
    1650                1655                1660                

Ala Lys Ala Glu Asn Gly Asp Ile Leu Gly Glu Tyr Arg Leu His Phe 
1665                1670                1675                1680

Thr Lys Asp Lys Asn Leu Leu Ser His Lys Pro Val Ala Ala Val Lys 
                1685                1690                1695    

Gln Ala Arg Leu Leu Gln Val Gly Gln Ala Leu Glu Leu Pro Thr Lys 
            1700                1705                1710        

Val Pro Val Tyr Phe Thr Gly Lys Asp Gly Tyr Glu Thr Lys Asp Leu 
        1715                1720                1725            

Thr Val Glu Trp Glu Glu Val Pro Ala Glu Asn Leu Thr Lys Ala Gly 
    1730                1735                1740                

Gln Phe Thr Val Arg Gly Arg Val Leu Gly Ser Asn Leu Val Ala Glu 
1745                1750                1755                1760

Val Thr Val Arg Val Thr Asp Lys Leu Gly Glu Thr Leu Ser Asp Asn 
                1765                1770                1775    

Pro Asn Tyr Asp Glu Asn Ser Asn Gln Ala Phe Ala Ser Ala Thr Asn 
            1780                1785                1790        

Asp Ile Asp Lys Asn Ser His Asp Arg Val Asp Tyr Leu Asn Asp Gly 
        1795                1800                1805            

Asp His Ser Glu Asn Arg Arg Trp Thr Asn Trp Ser Pro Thr Pro Ser 
    1810                1815                1820                

Ser Asn Pro Glu Val Ser Ala Gly Val Ile Phe Arg Glu Asn Gly Lys 
1825                1830                1835                1840

Ile Val Glu Arg Thr Val Ala Gln Ala Lys Leu His Phe Phe Ala Asp 
                1845                1850                1855    

Ser Gly Thr Asp Ala Pro Ser Lys Leu Val Leu Glu Arg Tyr Val Gly 
            1860                1865                1870        

Pro Gly Phe Glu Val Pro Thr Tyr Tyr Ser Asn Tyr Gln Ala Tyr Glu 
        1875                1880                1885            

Ser Gly His Pro Phe Asn Asn Pro Glu Asn Trp Glu Ala Val Pro Tyr 
    1890                1895                1900                

Arg Ala Asp Lys Asp Ile Ala Ala Gly Asp Glu Ile Asn Val Thr Phe 
1905                1910                1915                1920

Lys Ala Val Lys Ala Lys Val Met Arg Trp Arg Met Glu Arg Lys Ala 
                1925                1930                1935    

Asp Lys Ser Gly Val Ala Met Ile Glu Met Thr Phe Leu Ala Pro Ser 
            1940                1945                1950        

Glu Leu Pro Gln Glu Ser Thr Gln Ser Lys Ile Leu Val Asp Gly Lys 
        1955                1960                1965            

Glu Leu Ala Asp Phe Ala Glu Asn Arg Gln Asp Tyr Gln Ile Thr Tyr 
    1970                1975                1980                

Lys Gly Gln Arg Pro Lys Val Ser Val Glu Glu Asn Asn Gln Val Ala 
1985                1990                1995                2000

Ser Thr Val Val Asp Ser Gly Glu Asp Ser Leu Pro Val Leu Val Arg 
                2005                2010                2015    

Leu Val Ser Glu Ser Gly Lys Gln Val Lys Glu Tyr Arg Ile Gln Leu 
            2020                2025                2030        

Thr Lys Glu Lys Pro Val Ser Ala Val Gln Glu Asp Leu Pro Lys Leu 
        2035                2040                2045            

Glu Phe Val Glu Lys Asp Leu Ala Tyr Lys Thr Val Glu Lys Lys Asp 
    2050                2055                2060                

Ser Thr Leu Tyr Leu Gly Glu Thr Arg Val Glu Gln Glu Gly Lys Val 
2065                2070                2075                2080

Gly Lys Glu Arg Ile Phe Thr Val Ile Asn Pro Asp Gly Ser Lys Glu 
                2085                2090                2095    

Glu Lys Leu Arg Glu Val Val Glu Val Pro Thr Asp Arg Ile Val Leu 
            2100                2105                2110        

Val Gly Thr Lys Pro Val Ala Gln Glu Ala Lys Lys Pro Gln Val Ser 
        2115                2120                2125            

Glu Lys Ala Asp Thr Lys Pro Ile Asp Ser Ser Glu Ala Asp Gln Thr 
    2130                2135                2140                

Asn Lys Ala Gln 
2145            

<210>   278
<211>   1063
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   shortened version of spr0565

<400>   278
Asp Glu Thr Leu Ile Thr His Thr Ala Glu Lys Pro Lys Glu Glu Lys 
1               5                   10                  15      

Met Ile Val Glu Glu Lys Ala Asp Lys Ala Leu Glu Thr Lys Asn Val 
            20                  25                  30          

Val Glu Arg Thr Glu Gln Ser Glu Pro Ser Ser Thr Glu Ala Ile Ala 
        35                  40                  45              

Ser Glu Lys Lys Glu Asp Glu Ala Val Thr Pro Lys Glu Glu Lys Val 
    50                  55                  60                  

Ser Ala Lys Pro Glu Glu Lys Ala Pro Arg Ile Glu Ser Gln Ala Ser 
65                  70                  75                  80  

Ser Gln Glu Lys Pro Leu Lys Glu Asp Ala Lys Ala Val Thr Asn Glu 
                85                  90                  95      

Glu Val Asn Gln Met Ile Glu Asn Arg Lys Val Asp Phe Asn Gln Asn 
            100                 105                 110         

Trp Tyr Phe Lys Leu Asn Ala Asn Ser Lys Glu Ala Ile Lys Pro Asp 
        115                 120                 125             

Ala Asp Val Ser Thr Trp Lys Lys Leu Asp Leu Pro Tyr Asp Trp Ser 
    130                 135                 140                 

Ile Phe Asn Asp Phe Asp His Glu Ser Pro Ala Gln Asn Glu Gly Gly 
145                 150                 155                 160 

Gln Leu Asn Gly Gly Glu Ala Trp Tyr Arg Lys Thr Phe Lys Leu Asp 
                165                 170                 175     

Glu Lys Asp Leu Lys Lys Asn Val Arg Leu Thr Phe Asp Gly Val Tyr 
            180                 185                 190         

Met Asp Ser Gln Val Tyr Val Asn Gly Gln Leu Val Gly His Tyr Pro 
        195                 200                 205             

Asn Gly Tyr Asn Gln Phe Ser Tyr Asp Ile Thr Lys Tyr Leu Tyr Lys 
    210                 215                 220                 

Asp Gly Arg Glu Asn Val Ile Ala Val His Ala Val Asn Lys Gln Pro 
225                 230                 235                 240 

Ser Ser Arg Trp Tyr Ser Gly Ser Gly Ile Tyr Arg Asp Val Thr Leu 
                245                 250                 255     

Gln Val Thr Asp Lys Val His Val Glu Lys Asn Gly Thr Thr Ile Leu 
            260                 265                 270         

Thr Pro Lys Leu Glu Glu Gln Gln His Gly Lys Val Glu Thr His Val 
        275                 280                 285             

Thr Ser Lys Ile Val Asn Thr Asp Asp Lys Asp His Glu Leu Val Ala 
    290                 295                 300                 

Glu Tyr Gln Ile Val Glu Arg Gly Gly His Ala Val Thr Gly Leu Val 
305                 310                 315                 320 

Arg Thr Ala Ser Arg Thr Leu Lys Ala His Glu Ser Thr Ser Leu Asp 
                325                 330                 335     

Ala Ile Leu Glu Val Glu Arg Pro Lys Leu Trp Thr Val Leu Asn Asp 
            340                 345                 350         

Lys Pro Ala Leu Tyr Glu Leu Ile Thr Arg Val Tyr Arg Asp Gly Gln 
        355                 360                 365             

Leu Val Asp Ala Lys Lys Asp Leu Phe Gly Tyr Arg Tyr Tyr His Trp 
    370                 375                 380                 

Thr Pro Asn Glu Gly Phe Ser Leu Asn Gly Glu Arg Ile Lys Phe His 
385                 390                 395                 400 

Gly Val Ser Leu His His Asp His Gly Ala Leu Gly Ala Glu Glu Asn 
                405                 410                 415     

Tyr Lys Ala Glu Tyr Arg Arg Leu Lys Gln Met Lys Glu Met Gly Val 
            420                 425                 430         

Asn Ser Ile Arg Thr Thr His Asn Pro Ala Ser Glu Gln Thr Leu Gln 
        435                 440                 445             

Ile Ala Ala Glu Leu Gly Leu Leu Val Gln Glu Glu Ala Phe Asp Thr 
    450                 455                 460                 

Trp Tyr Gly Gly Lys Lys Pro Tyr Asp Tyr Gly Arg Phe Phe Glu Lys 
465                 470                 475                 480 

Asp Ala Thr His Pro Glu Ala Arg Lys Gly Glu Lys Trp Ser Asp Phe 
                485                 490                 495     

Asp Leu Arg Thr Met Val Glu Arg Gly Lys Asn Asn Pro Ala Ile Phe 
            500                 505                 510         

Met Trp Ser Ile Gly Asn Glu Ile Gly Glu Ala Asn Gly Asp Ala His 
        515                 520                 525             

Ser Leu Ala Thr Val Lys Arg Leu Val Lys Val Ile Lys Asp Val Asp 
    530                 535                 540                 

Lys Thr Arg Tyr Val Thr Met Gly Ala Asp Lys Phe Arg Phe Gly Asn 
545                 550                 555                 560 

Gly Ser Gly Gly His Glu Lys Ile Ala Asp Glu Leu Asp Ala Val Gly 
                565                 570                 575     

Phe Asn Tyr Ser Glu Asp Asn Tyr Lys Ala Leu Arg Ala Lys His Pro 
            580                 585                 590         

Lys Trp Leu Ile Tyr Gly Ser Glu Thr Ser Ser Ala Thr Arg Thr Arg 
        595                 600                 605             

Gly Ser Tyr Tyr Arg Pro Glu Arg Glu Leu Lys His Ser Asn Gly Pro 
    610                 615                 620                 

Glu Arg Asn Tyr Glu Gln Ser Asp Tyr Gly Asn Asp Arg Val Gly Trp 
625                 630                 635                 640 

Gly Lys Thr Ala Thr Ala Ser Trp Thr Phe Asp Arg Asp Asn Ala Gly 
                645                 650                 655     

Tyr Ala Gly Gln Phe Ile Trp Thr Gly Thr Asp Tyr Ile Gly Glu Pro 
            660                 665                 670         

Thr Pro Trp His Asn Gln Asn Gln Thr Pro Val Lys Ser Ser Tyr Phe 
        675                 680                 685             

Gly Ile Val Asp Thr Ala Gly Ile Pro Lys His Asp Phe Tyr Leu Tyr 
    690                 695                 700                 

Gln Ser Gln Trp Val Ser Val Lys Lys Lys Pro Met Val His Leu Leu 
705                 710                 715                 720 

Pro His Trp Asn Trp Glu Asn Lys Glu Leu Ala Ser Lys Val Ala Asp 
                725                 730                 735     

Ser Glu Gly Lys Ile Pro Val Arg Ala Tyr Ser Asn Ala Ser Ser Val 
            740                 745                 750         

Glu Leu Phe Leu Asn Gly Lys Ser Leu Gly Leu Lys Thr Phe Asn Lys 
        755                 760                 765             

Lys Gln Thr Ser Asp Gly Arg Thr Tyr Gln Glu Gly Ala Asn Ala Asn 
    770                 775                 780                 

Glu Leu Tyr Leu Glu Trp Lys Val Ala Tyr Gln Pro Gly Thr Leu Glu 
785                 790                 795                 800 

Ala Ile Ala Arg Asp Glu Ser Gly Lys Glu Ile Ala Arg Asp Lys Ile 
                805                 810                 815     

Thr Thr Ala Gly Lys Pro Ala Ala Val Arg Leu Ile Lys Glu Asp His 
            820                 825                 830         

Ala Ile Ala Ala Asp Gly Lys Asp Leu Thr Tyr Ile Tyr Tyr Glu Ile 
        835                 840                 845             

Val Asp Ser Gln Gly Asn Val Val Pro Thr Ala Asn Asn Leu Val Arg 
    850                 855                 860                 

Phe Gln Leu His Gly Gln Gly Gln Leu Val Gly Val Asp Asn Gly Glu 
865                 870                 875                 880 

Gln Ala Ser Arg Glu Arg Tyr Lys Ala Gln Ala Asp Gly Ser Trp Ile 
                885                 890                 895     

Arg Lys Ala Phe Asn Gly Lys Gly Val Ala Ile Val Lys Ser Thr Glu 
            900                 905                 910         

Gln Ala Gly Lys Phe Thr Leu Thr Ala His Ser Asp Leu Leu Lys Ser 
        915                 920                 925             

Asn Gln Val Thr Val Phe Thr Gly Lys Lys Glu Gly Gln Glu Lys Thr 
    930                 935                 940                 

Val Leu Gly Thr Glu Val Pro Lys Val Gln Thr Ile Ile Gly Glu Ala 
945                 950                 955                 960 

Pro Glu Met Pro Thr Thr Val Pro Phe Val Tyr Ser Asp Gly Ser Arg 
                965                 970                 975     

Ala Glu Arg Pro Val Thr Trp Ser Leu Val Asp Val Ser Lys Pro Gly 
            980                 985                 990         

Ile Val Thr Val Lys Gly Met Ala Asp Gly Arg Glu Val Glu Ala Arg 
        995                 1000                1005            

Val Glu Val Ile Ala Leu Lys Ser Glu Leu Pro Val Val Lys Arg Ile 
    1010                1015                1020                

Ala Pro Asn Thr Asn Leu Asn Ser Val Asp Lys Ser Val Ser Tyr Val 
1025                1030                1035                1040

Leu Thr Asp Gly Ser Val Gln Glu Tyr Glu Val Asp Lys Trp Glu Ile 
                1045                1050                1055    

Ala Glu Glu Asp Lys Ala Lys 
            1060            

<210>   279
<211>   1093
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   shortened version of spr0565

<400>   279
Ile Ala Glu Glu Asp Lys Ala Lys Leu Ala Ile Pro Gly Ser Arg Ile 
1               5                   10                  15      

Gln Ala Thr Gly Tyr Leu Glu Gly Gln Pro Ile His Ala Thr Leu Val 
            20                  25                  30          

Val Glu Glu Gly Asn Pro Ala Ala Pro Val Val Pro Thr Val Thr Val 
        35                  40                  45              

Gly Gly Glu Ala Val Thr Gly Leu Thr Ser Arg Gln Pro Met Gln Tyr 
    50                  55                  60                  

Arg Thr Leu Ser Tyr Gly Ala Gln Leu Pro Glu Val Thr Ala Ser Ala 
65                  70                  75                  80  

Glu Asn Ala Asp Val Thr Val Leu Gln Ala Ser Ala Ala Asn Gly Met 
                85                  90                  95      

Arg Ala Ser Ile Phe Ile Gln Pro Lys Asp Gly Gly Pro Leu Gln Thr 
            100                 105                 110         

Tyr Ala Ile Gln Phe Leu Glu Glu Ala Pro Lys Ile Ala His Leu Ser 
        115                 120                 125             

Leu Gln Val Glu Lys Ala Asp Ser Leu Lys Glu Asp Gln Thr Val Lys 
    130                 135                 140                 

Leu Ser Val Arg Ala His Tyr Gln Asp Gly Thr Gln Ala Val Leu Pro 
145                 150                 155                 160 

Ala Asp Lys Val Thr Phe Ser Thr Ser Gly Glu Gly Glu Val Ala Ile 
                165                 170                 175     

Arg Lys Gly Met Leu Glu Leu His Lys Pro Gly Ala Val Thr Leu Asn 
            180                 185                 190         

Ala Glu Tyr Glu Gly Ala Lys Gly Gln Val Glu Leu Thr Ile Gln Ala 
        195                 200                 205             

Asn Thr Glu Lys Lys Ile Ala Gln Ser Ile Arg Pro Val Asn Val Val 
    210                 215                 220                 

Thr Asp Leu His Gln Glu Pro Ser Leu Pro Ala Thr Val Thr Val Glu 
225                 230                 235                 240 

Tyr Asp Lys Gly Phe Pro Lys Thr His Lys Val Thr Trp Gln Ala Ile 
                245                 250                 255     

Pro Lys Glu Lys Leu Asp Ser Tyr Gln Ile Phe Glu Val Leu Gly Lys 
            260                 265                 270         

Val Glu Gly Ile Asp Leu Glu Ala Arg Ala Lys Val Ser Val Glu Gly 
        275                 280                 285             

Ile Val Ser Val Glu Glu Val Ser Val Thr Thr Pro Ile Ala Glu Ala 
    290                 295                 300                 

Pro Gln Leu Pro Glu Ser Val Arg Thr Tyr Asp Ser Asn Gly His Val 
305                 310                 315                 320 

Ser Ser Ala Lys Val Ala Trp Asp Ala Ile Arg Pro Glu Gln Tyr Ala 
                325                 330                 335     

Lys Glu Gly Val Phe Thr Val Asn Gly Arg Leu Glu Gly Thr Gln Leu 
            340                 345                 350         

Thr Thr Lys Leu His Val Arg Val Ser Ala Gln Thr Glu Gln Gly Ala 
        355                 360                 365             

Asn Ile Ser Asp Gln Trp Thr Gly Ser Glu Leu Pro Leu Ala Phe Ala 
    370                 375                 380                 

Ser Asp Ser Asn Pro Ser Asp Pro Val Ser Asn Val Asn Asp Lys Leu 
385                 390                 395                 400 

Ile Ser Tyr Asn Asn Gln Pro Ala Asn Arg Trp Thr Asn Trp Asn Arg 
                405                 410                 415     

Ser Asn Pro Glu Ala Ser Val Gly Val Leu Phe Gly Asp Ser Gly Ile 
            420                 425                 430         

Leu Ser Lys Arg Ser Val Asp Asn Leu Ser Val Gly Phe His Glu Asp 
        435                 440                 445             

His Gly Val Gly Ala Pro Lys Ser Tyr Val Ile Glu Tyr Tyr Val Gly 
    450                 455                 460                 

Lys Thr Val Pro Thr Ala Pro Lys Asn Pro Ser Phe Val Gly Asn Glu 
465                 470                 475                 480 

Asp His Val Phe Asn Asp Ser Ala Asn Trp Lys Pro Val Thr Asn Leu 
                485                 490                 495     

Lys Ala Pro Ala Gln Leu Lys Ala Gly Glu Met Asn His Phe Ser Phe 
            500                 505                 510         

Asp Lys Val Glu Thr Tyr Ala Ile Arg Ile Arg Met Val Lys Ala Asp 
        515                 520                 525             

Asn Lys Arg Gly Thr Ser Ile Thr Glu Val Gln Ile Phe Ala Lys Gln 
    530                 535                 540                 

Val Ala Ala Ala Lys Gln Gly Gln Thr Arg Ile Gln Val Asp Gly Lys 
545                 550                 555                 560 

Asp Leu Ala Asn Phe Asn Pro Asp Leu Thr Asp Tyr Tyr Leu Glu Ser 
                565                 570                 575     

Val Asp Gly Lys Val Pro Ala Val Thr Ala Asn Val Ser Asn Asn Gly 
            580                 585                 590         

Leu Ala Thr Val Val Pro Ser Val Arg Glu Gly Glu Pro Val Arg Val 
        595                 600                 605             

Ile Ala Lys Ala Glu Asn Gly Asp Ile Leu Gly Glu Tyr Arg Leu His 
    610                 615                 620                 

Phe Thr Lys Asp Lys Asn Leu Leu Ser His Lys Pro Val Ala Ala Val 
625                 630                 635                 640 

Lys Gln Ala Arg Leu Leu Gln Val Gly Gln Ala Leu Glu Leu Pro Thr 
                645                 650                 655     

Lys Val Pro Val Tyr Phe Thr Gly Lys Asp Gly Tyr Glu Thr Lys Asp 
            660                 665                 670         

Leu Thr Val Glu Trp Glu Glu Val Pro Ala Glu Asn Leu Thr Lys Ala 
        675                 680                 685             

Gly Gln Phe Thr Val Arg Gly Arg Val Leu Gly Ser Asn Leu Val Ala 
    690                 695                 700                 

Glu Val Thr Val Arg Val Thr Asp Lys Leu Gly Glu Thr Leu Ser Asp 
705                 710                 715                 720 

Asn Pro Asn Tyr Asp Glu Asn Ser Asn Gln Ala Phe Ala Ser Ala Thr 
                725                 730                 735     

Asn Asp Ile Asp Lys Asn Ser His Asp Arg Val Asp Tyr Leu Asn Asp 
            740                 745                 750         

Gly Asp His Ser Glu Asn Arg Arg Trp Thr Asn Trp Ser Pro Thr Pro 
        755                 760                 765             

Ser Ser Asn Pro Glu Val Ser Ala Gly Val Ile Phe Arg Glu Asn Gly 
    770                 775                 780                 

Lys Ile Val Glu Arg Thr Val Ala Gln Ala Lys Leu His Phe Phe Ala 
785                 790                 795                 800 

Asp Ser Gly Thr Asp Ala Pro Ser Lys Leu Val Leu Glu Arg Tyr Val 
                805                 810                 815     

Gly Pro Gly Phe Glu Val Pro Thr Tyr Tyr Ser Asn Tyr Gln Ala Tyr 
            820                 825                 830         

Glu Ser Gly His Pro Phe Asn Asn Pro Glu Asn Trp Glu Ala Val Pro 
        835                 840                 845             

Tyr Arg Ala Asp Lys Asp Ile Ala Ala Gly Asp Glu Ile Asn Val Thr 
    850                 855                 860                 

Phe Lys Ala Val Lys Ala Lys Val Met Arg Trp Arg Met Glu Arg Lys 
865                 870                 875                 880 

Ala Asp Lys Ser Gly Val Ala Met Ile Glu Met Thr Phe Leu Ala Pro 
                885                 890                 895     

Ser Glu Leu Pro Gln Glu Ser Thr Gln Ser Lys Ile Leu Val Asp Gly 
            900                 905                 910         

Lys Glu Leu Ala Asp Phe Ala Glu Asn Arg Gln Asp Tyr Gln Ile Thr 
        915                 920                 925             

Tyr Lys Gly Gln Arg Pro Lys Val Ser Val Glu Glu Asn Asn Gln Val 
    930                 935                 940                 

Ala Ser Thr Val Val Asp Ser Gly Glu Asp Ser Leu Pro Val Leu Val 
945                 950                 955                 960 

Arg Leu Val Ser Glu Ser Gly Lys Gln Val Lys Glu Tyr Arg Ile Gln 
                965                 970                 975     

Leu Thr Lys Glu Lys Pro Val Ser Ala Val Gln Glu Asp Leu Pro Lys 
            980                 985                 990         

Leu Glu Phe Val Glu Lys Asp Leu Ala Tyr Lys Thr Val Glu Lys Lys 
        995                 1000                1005            

Asp Ser Thr Leu Tyr Leu Gly Glu Thr Arg Val Glu Gln Glu Gly Lys 
    1010                1015                1020                

Val Gly Lys Glu Arg Ile Phe Thr Val Ile Asn Pro Asp Gly Ser Lys 
1025                1030                1035                1040

Glu Glu Lys Leu Arg Glu Val Val Glu Val Pro Thr Asp Arg Ile Val 
                1045                1050                1055    

Leu Val Gly Thr Lys Pro Val Ala Gln Glu Ala Lys Lys Pro Gln Val 
            1060                1065                1070        

Ser Glu Lys Ala Asp Thr Lys Pro Ile Asp Ser Ser Glu Ala Asp Gln 
        1075                1080                1085            

Thr Asn Lys Ala Gln 
    1090            

<210>   280
<211>   2233
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   variant form of spr0565

<400>   280
Met Gly Lys Gly His Trp Asn Arg Lys Arg Val Tyr Ser Ile Arg Lys 
1               5                   10                  15      

Phe Ala Val Gly Ala Cys Ser Val Met Ile Gly Thr Cys Ala Val Leu 
            20                  25                  30          

Leu Gly Gly Asn Ile Ala Gly Glu Ser Val Val Tyr Ala Asp Glu Thr 
        35                  40                  45              

Leu Ile Thr His Thr Ala Glu Lys Pro Lys Glu Glu Lys Met Ile Val 
    50                  55                  60                  

Glu Glu Lys Ala Asp Lys Ala Leu Glu Thr Lys Asn Ile Val Glu Arg 
65                  70                  75                  80  

Thr Glu Gln Ser Glu Pro Ser Ser Thr Glu Ala Ile Ala Ser Glu Lys 
                85                  90                  95      

Lys Glu Asp Glu Ala Val Thr Pro Lys Glu Glu Lys Val Ser Ala Lys 
            100                 105                 110         

Pro Glu Glu Lys Ala Pro Arg Ile Glu Ser Gln Ala Ser Asn Gln Glu 
        115                 120                 125             

Lys Pro Leu Lys Glu Asp Ala Lys Ala Val Thr Asn Glu Glu Val Asn 
    130                 135                 140                 

Gln Met Ile Glu Asp Arg Lys Val Asp Phe Asn Gln Asn Trp Tyr Phe 
145                 150                 155                 160 

Lys Leu Asn Ala Asn Ser Lys Glu Ala Ile Lys Pro Asp Ala Asp Val 
                165                 170                 175     

Ser Thr Trp Lys Lys Leu Asp Leu Pro Tyr Asp Trp Ser Ile Phe Asn 
            180                 185                 190         

Asp Phe Asp His Glu Ser Pro Ala Gln Asn Glu Gly Gly Gln Leu Asn 
        195                 200                 205             

Gly Gly Glu Ala Trp Tyr Arg Lys Thr Phe Lys Leu Asp Glu Lys Asp 
    210                 215                 220                 

Leu Lys Lys Asn Val Arg Leu Thr Phe Asp Gly Val Tyr Met Asp Ser 
225                 230                 235                 240 

Gln Val Tyr Val Asn Gly Gln Leu Val Gly His Tyr Pro Asn Gly Tyr 
                245                 250                 255     

Asn Gln Phe Ser Tyr Asp Ile Thr Lys Tyr Leu Gln Lys Asp Gly Arg 
            260                 265                 270         

Glu Asn Val Ile Ala Val His Ala Val Asn Lys Gln Pro Ser Ser Arg 
        275                 280                 285             

Trp Tyr Ser Gly Ser Gly Ile Tyr Arg Asp Val Thr Leu Gln Val Thr 
    290                 295                 300                 

Asp Lys Val His Val Glu Lys Asn Gly Thr Thr Ile Leu Thr Pro Lys 
305                 310                 315                 320 

Leu Glu Glu Gln Gln His Gly Lys Val Glu Thr His Val Thr Ser Lys 
                325                 330                 335     

Ile Val Asn Thr Asp Asp Lys Asp His Glu Leu Val Ala Glu Tyr Gln 
            340                 345                 350         

Ile Val Glu Arg Gly Gly His Ala Val Thr Gly Leu Val Arg Thr Ala 
        355                 360                 365             

Ser Arg Thr Leu Lys Ala His Glu Ser Thr Ser Leu Asp Ala Ile Leu 
    370                 375                 380                 

Glu Val Glu Arg Pro Lys Leu Trp Thr Val Leu Asn Asp Lys Pro Ala 
385                 390                 395                 400 

Leu Tyr Glu Leu Ile Thr Arg Val Tyr Arg Asp Gly Gln Leu Val Asp 
                405                 410                 415     

Ala Lys Lys Asp Leu Phe Gly Tyr Arg Tyr Tyr His Trp Thr Pro Asn 
            420                 425                 430         

Glu Gly Phe Ser Leu Asn Gly Glu Arg Ile Lys Phe His Gly Val Ser 
        435                 440                 445             

Leu His His Asp His Gly Ala Leu Gly Ala Glu Glu Asn Tyr Lys Ala 
    450                 455                 460                 

Glu Tyr Arg Arg Leu Lys Gln Met Lys Glu Met Gly Val Asn Ser Ile 
465                 470                 475                 480 

Arg Thr Thr His Asn Pro Ala Ser Glu Gln Thr Leu Gln Ile Ala Ala 
                485                 490                 495     

Glu Leu Gly Leu Leu Val Gln Glu Glu Ala Phe Asp Thr Trp Tyr Gly 
            500                 505                 510         

Gly Lys Lys Pro Tyr Asp Tyr Gly Arg Phe Phe Glu Lys Asp Ala Thr 
        515                 520                 525             

His Pro Glu Ala Arg Lys Gly Glu Lys Trp Ser Asp Phe Asp Leu Arg 
    530                 535                 540                 

Thr Met Val Glu Arg Gly Lys Asn Asn Pro Ala Ile Phe Met Trp Ser 
545                 550                 555                 560 

Ile Gly Asn Glu Ile Gly Glu Ala Asn Gly Asp Ala His Ser Leu Ala 
                565                 570                 575     

Thr Val Lys Arg Leu Val Lys Val Ile Lys Asp Val Asp Lys Thr Arg 
            580                 585                 590         

Tyr Val Thr Met Gly Ala Asp Lys Phe Arg Phe Gly Asn Gly Ser Gly 
        595                 600                 605             

Gly His Glu Lys Ile Ala Asp Glu Leu Asp Ala Val Gly Phe Asn Tyr 
    610                 615                 620                 

Ser Glu Asp Asn Tyr Lys Ala Leu Arg Ala Lys His Pro Lys Trp Leu 
625                 630                 635                 640 

Ile Tyr Gly Ser Glu Thr Ser Ser Ala Thr Arg Thr Arg Gly Ser Tyr 
                645                 650                 655     

Tyr Arg Pro Glu Arg Glu Leu Lys His Ser Asn Gly Pro Glu Arg Asn 
            660                 665                 670         

Tyr Glu Gln Ser Asp Tyr Gly Asn Asp Arg Val Gly Trp Gly Lys Thr 
        675                 680                 685             

Ala Thr Ala Ser Trp Thr Phe Asp Arg Asp Asn Ala Gly Tyr Ala Gly 
    690                 695                 700                 

Gln Phe Ile Trp Thr Gly Thr Asp Tyr Ile Gly Glu Pro Thr Pro Trp 
705                 710                 715                 720 

His Asn Gln Asn Gln Thr Pro Val Lys Ser Ser Tyr Phe Gly Ile Val 
                725                 730                 735     

Asp Thr Ala Gly Ile Pro Lys His Asp Phe Tyr Leu Tyr Gln Ser Gln 
            740                 745                 750         

Trp Val Ser Val Lys Lys Lys Pro Met Val His Leu Leu Pro His Trp 
        755                 760                 765             

Asn Trp Glu Asn Lys Glu Leu Ala Ser Lys Val Ala Asp Ser Glu Gly 
    770                 775                 780                 

Lys Ile Pro Val Arg Ala Tyr Ser Asn Ala Ser Ser Val Glu Leu Phe 
785                 790                 795                 800 

Leu Asn Gly Lys Ser Leu Gly Leu Lys Thr Phe Asn Lys Lys Gln Thr 
                805                 810                 815     

Ser Asp Gly Arg Thr Tyr Gln Glu Gly Ala Asn Ala Asn Glu Leu Tyr 
            820                 825                 830         

Leu Glu Trp Lys Val Ala Tyr Gln Pro Gly Thr Leu Glu Ala Ile Ala 
        835                 840                 845             

Arg Asp Glu Ser Gly Lys Glu Ile Ala Arg Asp Lys Ile Thr Thr Ala 
    850                 855                 860                 

Gly Lys Pro Ala Ala Val Arg Leu Ile Lys Glu Asp His Ala Ile Ala 
865                 870                 875                 880 

Ala Asp Gly Lys Asp Leu Thr Tyr Ile Tyr Tyr Glu Ile Val Asp Ser 
                885                 890                 895     

Gln Gly Asn Val Val Pro Thr Ala Asn Asn Leu Val Arg Phe Gln Leu 
            900                 905                 910         

His Gly Gln Gly Gln Leu Val Gly Val Asp Asn Gly Glu Gln Ala Ser 
        915                 920                 925             

Arg Glu Arg Tyr Lys Ala Gln Ala Asp Gly Ser Trp Ile Arg Lys Ala 
    930                 935                 940                 

Phe Asn Gly Lys Gly Val Ala Ile Val Lys Ser Thr Glu Gln Ala Gly 
945                 950                 955                 960 

Lys Phe Thr Leu Thr Ala His Ser Asp Leu Leu Lys Ser Asn Gln Val 
                965                 970                 975     

Thr Val Phe Thr Gly Lys Lys Glu Gly Gln Glu Lys Thr Val Leu Gly 
            980                 985                 990         

Thr Glu Val Pro Lys Val Gln Thr Ile Ile Gly Glu Ala Pro Glu Met 
        995                 1000                1005            

Pro Thr Thr Val Pro Phe Val Tyr Ser Asp Gly Ser Arg Ala Glu Arg 
    1010                1015                1020                

Pro Val Thr Trp Ser Ser Val Asp Val Ser Lys Pro Gly Ile Val Thr 
1025                1030                1035                1040

Val Lys Gly Met Ala Asp Gly Arg Glu Val Glu Ala Arg Val Glu Val 
                1045                1050                1055    

Ile Ala Leu Lys Ser Glu Leu Pro Val Val Lys Arg Ile Ala Pro Asn 
            1060                1065                1070        

Thr Asp Leu Asn Ser Val Asp Lys Ser Val Ser Tyr Val Leu Ile Asp 
        1075                1080                1085            

Gly Ser Val Glu Glu Tyr Glu Val Asp Lys Trp Glu Ile Ala Glu Glu 
    1090                1095                1100                

Asp Lys Ala Lys Leu Ala Ile Pro Gly Ser Arg Ile Gln Ala Thr Gly 
1105                1110                1115                1120

Tyr Leu Glu Gly Gln Pro Ile His Ala Thr Leu Val Val Glu Glu Gly 
                1125                1130                1135    

Asn Pro Ala Ala Pro Ala Val Pro Thr Val Thr Val Gly Gly Glu Ala 
            1140                1145                1150        

Val Thr Gly Leu Thr Ser Gln Lys Pro Met Gln Tyr Arg Thr Leu Ala 
        1155                1160                1165            

Tyr Gly Ala Lys Leu Pro Glu Val Thr Ala Ser Ala Lys Asn Ala Ala 
    1170                1175                1180                

Val Thr Val Leu Gln Ala Ser Ala Ala Asn Gly Met Arg Ala Ser Ile 
1185                1190                1195                1200

Phe Ile Gln Pro Lys Asp Gly Gly Pro Leu Gln Thr Tyr Ala Ile Gln 
                1205                1210                1215    

Phe Leu Glu Glu Ala Pro Lys Ile Ala His Leu Ser Leu Gln Val Glu 
            1220                1225                1230        

Lys Ala Asp Ser Leu Lys Glu Asp Gln Thr Val Lys Leu Ser Val Arg 
        1235                1240                1245            

Ala His Tyr Gln Asp Gly Thr Gln Ala Val Leu Pro Ala Asp Lys Val 
    1250                1255                1260                

Thr Phe Ser Thr Ser Gly Glu Gly Glu Val Ala Ile Arg Lys Gly Met 
1265                1270                1275                1280

Leu Glu Leu His Lys Pro Gly Ala Val Thr Leu Asn Ala Glu Tyr Glu 
                1285                1290                1295    

Gly Ala Lys Asp Gln Val Glu Leu Thr Ile Gln Ala Asn Thr Glu Lys 
            1300                1305                1310        

Lys Ile Ala Gln Ser Ile Arg Pro Val Asn Val Val Thr Asp Leu His 
        1315                1320                1325            

Gln Glu Pro Ser Leu Pro Ala Thr Val Thr Val Glu Tyr Asp Lys Gly 
    1330                1335                1340                

Phe Pro Lys Thr His Lys Val Thr Trp Gln Ala Ile Pro Lys Glu Lys 
1345                1350                1355                1360

Leu Asp Ser Tyr Gln Thr Phe Glu Val Leu Gly Lys Val Glu Gly Ile 
                1365                1370                1375    

Asp Leu Glu Ala Arg Ala Lys Val Ser Val Glu Gly Ile Val Ser Val 
            1380                1385                1390        

Glu Glu Val Ser Val Thr Thr Pro Ile Ala Glu Ala Pro Gln Leu Pro 
        1395                1400                1405            

Glu Ser Val Arg Thr Tyr Asp Ser Asn Gly His Val Ser Ser Ala Lys 
    1410                1415                1420                

Val Ala Trp Asp Ala Ile Arg Pro Glu Gln Tyr Ala Lys Glu Gly Val 
1425                1430                1435                1440

Phe Thr Val Asn Gly Arg Leu Glu Gly Thr Gln Leu Thr Thr Lys Leu 
                1445                1450                1455    

His Val Arg Val Ser Ala Gln Thr Glu Gln Gly Ala Asn Ile Ser Asp 
            1460                1465                1470        

Gln Trp Thr Gly Ser Glu Leu Pro Leu Ala Phe Ala Ser Asp Ser Asn 
        1475                1480                1485            

Pro Ser Asp Pro Val Ser Asn Val Asn Asp Lys Leu Ile Ser Tyr Asn 
    1490                1495                1500                

Asn Gln Pro Ala Asn Arg Trp Thr Asn Trp Asn Arg Thr Asn Pro Glu 
1505                1510                1515                1520

Ala Ser Val Gly Val Leu Phe Gly Asp Ser Gly Ile Leu Ser Lys Arg 
                1525                1530                1535    

Ser Val Asp Asn Leu Ser Val Gly Phe His Glu Asp His Gly Val Gly 
            1540                1545                1550        

Val Pro Lys Ser Tyr Val Ile Glu Tyr Tyr Val Gly Lys Thr Val Pro 
        1555                1560                1565            

Thr Ala Pro Lys Asn Pro Ser Phe Val Gly Asn Glu Asp His Val Phe 
    1570                1575                1580                

Asn Asp Ser Ala Asn Trp Lys Pro Val Thr Asn Leu Lys Ala Pro Ala 
1585                1590                1595                1600

Gln Leu Lys Ala Gly Glu Met Asn His Phe Ser Phe Asp Lys Val Glu 
                1605                1610                1615    

Thr Tyr Ala Val Arg Ile Arg Met Val Lys Ala Asp Asn Lys Arg Gly 
            1620                1625                1630        

Thr Ser Ile Thr Glu Val Gln Ile Phe Ala Lys Gln Val Ala Ala Ala 
        1635                1640                1645            

Lys Gln Gly Gln Thr Arg Ile Gln Val Asp Gly Lys Asp Leu Ala Asn 
    1650                1655                1660                

Phe Asn Pro Asp Leu Thr Asp Tyr Tyr Leu Glu Ser Val Asp Gly Lys 
1665                1670                1675                1680

Val Pro Ala Val Thr Ala Ser Val Ser Asn Asn Gly Leu Ala Thr Val 
                1685                1690                1695    

Val Pro Ser Val Arg Glu Gly Glu Pro Val Arg Val Ile Ala Lys Ala 
            1700                1705                1710        

Glu Asn Gly Asp Ile Leu Gly Glu Tyr Arg Leu His Phe Thr Lys Asp 
        1715                1720                1725            

Lys Ser Leu Leu Ser His Lys Pro Val Ala Ala Val Lys Gln Ala Arg 
    1730                1735                1740                

Leu Leu Gln Val Gly Gln Ala Leu Glu Leu Pro Thr Lys Val Pro Val 
1745                1750                1755                1760

Tyr Phe Thr Gly Lys Asp Gly Tyr Glu Thr Lys Asp Leu Thr Val Glu 
                1765                1770                1775    

Trp Glu Glu Val Pro Ala Glu Asn Leu Thr Lys Ala Gly Gln Phe Thr 
            1780                1785                1790        

Val Arg Gly Arg Val Leu Gly Ser Asn Leu Val Ala Glu Ile Thr Val 
        1795                1800                1805            

Arg Val Thr Asp Lys Leu Gly Glu Thr Leu Ser Asp Asn Pro Asn Tyr 
    1810                1815                1820                

Asp Glu Asn Ser Asn Gln Ala Phe Ala Ser Ala Thr Asn Asp Ile Asp 
1825                1830                1835                1840

Lys Asn Ser His Asp Arg Val Asp Tyr Leu Asn Asp Gly Asp His Ser 
                1845                1850                1855    

Glu Asn Arg Arg Trp Thr Asn Trp Ser Pro Thr Pro Ser Ser Asn Pro 
            1860                1865                1870        

Glu Val Ser Ala Gly Val Ile Phe Arg Glu Asn Gly Lys Ile Val Glu 
        1875                1880                1885            

Arg Thr Val Thr Gln Gly Lys Val Gln Phe Phe Ala Asp Ser Gly Thr 
    1890                1895                1900                

Asp Ala Pro Ser Lys Leu Val Leu Glu Arg Tyr Val Gly Pro Glu Phe 
1905                1910                1915                1920

Glu Val Pro Thr Tyr Tyr Ser Asn Tyr Gln Ala Tyr Asp Ala Asp His 
                1925                1930                1935    

Pro Phe Asn Asn Pro Glu Asn Trp Glu Ala Val Pro Tyr Arg Ala Asp 
            1940                1945                1950        

Lys Asp Ile Ala Ala Gly Asp Glu Ile Asn Val Thr Phe Lys Ala Ile 
        1955                1960                1965            

Lys Ala Lys Ala Met Arg Trp Arg Met Glu Arg Lys Ala Asp Lys Ser 
    1970                1975                1980                

Gly Val Ala Met Ile Glu Met Thr Phe Leu Ala Pro Ser Glu Leu Pro 
1985                1990                1995                2000

Gln Glu Ser Thr Gln Ser Lys Ile Leu Val Asp Gly Lys Glu Leu Ala 
                2005                2010                2015    

Asp Phe Ala Glu Asn Arg Gln Asp Tyr Gln Ile Thr Tyr Lys Gly Gln 
            2020                2025                2030        

Arg Pro Lys Val Ser Val Glu Glu Asn Asn Gln Val Ala Ser Thr Val 
        2035                2040                2045            

Val Asp Ser Gly Glu Asp Ser Phe Pro Val Leu Val Arg Leu Val Ser 
    2050                2055                2060                

Glu Ser Gly Lys Gln Val Lys Glu Tyr Arg Ile His Leu Thr Lys Glu 
2065                2070                2075                2080

Lys Pro Val Ser Glu Lys Thr Val Ala Ala Val Gln Glu Asp Leu Pro 
                2085                2090                2095    

Lys Ile Glu Phe Val Glu Lys Asp Leu Ala Tyr Lys Thr Val Glu Lys 
            2100                2105                2110        

Lys Asp Ser Thr Leu Tyr Leu Gly Glu Thr Arg Val Glu Gln Glu Gly 
        2115                2120                2125            

Lys Val Gly Lys Glu Arg Ile Phe Thr Ala Ile Asn Pro Asp Gly Ser 
    2130                2135                2140                

Lys Glu Glu Lys Leu Arg Glu Val Val Glu Val Pro Thr Asp Arg Ile 
2145                2150                2155                2160

Val Leu Val Gly Thr Lys Pro Val Ala Gln Glu Ala Lys Lys Pro Gln 
                2165                2170                2175    

Val Ser Glu Lys Ala Asp Thr Lys Pro Ile Asp Ser Ser Glu Ala Ser 
            2180                2185                2190        

Gln Thr Asn Lys Ala Gln Leu Pro Ser Thr Gly Ser Ala Ala Ser Gln 
        2195                2200                2205            

Ala Ala Val Ala Ala Gly Leu Thr Leu Leu Gly Leu Ser Ala Gly Leu 
    2210                2215                2220                

Val Val Thr Lys Gly Lys Lys Glu Asp 
2225                2230            

<210>   281
<211>   218
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   fragment of SEQ ID NO: 261 which omits the natural leader peptide sequence

<400>   281
Ala Leu Ile Phe Asn Thr Gln Ile Arg Asn Ile Phe Ile Val Trp Asn 
1               5                   10                  15      

Thr Asn Lys Tyr Gln Val Ser Gln Val Ser Lys Glu Lys Leu Glu Glu 
            20                  25                  30          

Asn Gln Asp Thr Glu Gly Asn Phe Asp Phe Asp Ser Val Lys Ala Ile 
        35                  40                  45              

Ser Ser Glu Ala Val Leu Thr Ser Gln Trp Asp Ala Gln Lys Leu Pro 
    50                  55                  60                  

Val Ile Gly Gly Ile Ala Ile Pro Glu Leu Glu Met Asn Leu Pro Ile 
65                  70                  75                  80  

Phe Lys Gly Leu Asp Asn Val Asn Leu Phe Tyr Gly Ala Gly Thr Met 
                85                  90                  95      

Lys Arg Glu Gln Val Met Gly Glu Gly Asn Tyr Ser Leu Ala Ser His 
            100                 105                 110         

His Ile Phe Gly Val Asp Asn Ala Asn Lys Met Leu Phe Ser Pro Leu 
        115                 120                 125             

Asp Asn Ala Lys Asn Gly Met Lys Ile Tyr Leu Thr Asp Lys Asn Lys 
    130                 135                 140                 

Val Tyr Thr Tyr Glu Ile Arg Glu Val Lys Arg Val Thr Pro Asp Arg 
145                 150                 155                 160 

Val Asp Glu Val Asp Asp Arg Asp Gly Val Asn Glu Ile Thr Leu Val 
                165                 170                 175     

Thr Cys Glu Asp Leu Ala Ala Thr Glu Arg Ile Ile Val Lys Gly Asp 
            180                 185                 190         

Leu Lys Glu Thr Lys Asp Tyr Ser Gln Thr Ser Asp Glu Ile Leu Thr 
        195                 200                 205             

Ala Phe Asn Gln Pro Tyr Lys Gln Phe Tyr 
    210                 215             

<210>   282
<211>   165
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   spr1345

<400>   282
Val Pro Lys Thr Ala Thr Ser Thr Glu Thr Lys Thr Ile Thr Arg Ile 
1               5                   10                  15      

Ile His Tyr Val Asp Lys Val Thr Asn Gln Asn Val Lys Glu Asp Val 
            20                  25                  30          

Val Gln Pro Val Thr Leu Ser Arg Thr Lys Thr Glu Asn Lys Val Thr 
        35                  40                  45              

Gly Val Val Thr Tyr Gly Glu Trp Thr Thr Gly Asn Trp Asp Glu Val 
    50                  55                  60                  

Ile Ser Gly Lys Ile Asp Lys Tyr Lys Asp Pro Asp Ile Pro Thr Val 
65                  70                  75                  80  

Glu Ser Gln Glu Val Thr Ser Asp Ser Ser Asp Lys Glu Ile Thr Val 
                85                  90                  95      

Arg Tyr Asp Arg Leu Ser Thr Pro Glu Lys Pro Ile Pro Gln Pro Asn 
            100                 105                 110         

Pro Glu His Pro Ser Val Pro Thr Pro Asn Pro Glu Leu Pro Asn Gln 
        115                 120                 125             

Glu Thr Pro Thr Pro Asp Lys Pro Thr Pro Glu Pro Gly Thr Pro Lys 
    130                 135                 140                 

Thr Glu Thr Pro Val Asn Pro Asp Pro Glu Val Pro Thr Tyr Glu Thr 
145                 150                 155                 160 

Gly Lys Arg Glu Glu 
                165 

<210>   283
<211>   680
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   Fragment of SEQ ID NO: 265 which omits the natural leader peptide sequence

<400>   283
Ala Ser Asp Gly Thr Trp Gln Gly Lys Gln Tyr Leu Lys Glu Asp Gly 
1               5                   10                  15      

Ser Gln Ala Ala Asn Glu Trp Val Phe Asp Thr His Tyr Gln Ser Trp 
            20                  25                  30          

Phe Tyr Ile Lys Ala Asp Ala Asn Tyr Ala Glu Asn Glu Trp Leu Lys 
        35                  40                  45              

Gln Gly Asp Asp Tyr Phe Tyr Leu Lys Ser Gly Gly Tyr Met Ala Lys 
    50                  55                  60                  

Ser Glu Trp Val Glu Asp Lys Gly Ala Phe Tyr Tyr Leu Asp Gln Asp 
65                  70                  75                  80  

Gly Lys Met Lys Arg Asn Ala Trp Val Gly Thr Ser Tyr Val Gly Ala 
                85                  90                  95      

Thr Gly Ala Lys Val Ile Glu Asp Trp Val Tyr Asp Ser Gln Tyr Asp 
            100                 105                 110         

Ala Trp Phe Tyr Ile Lys Ala Asp Gly Gln His Ala Glu Lys Glu Trp 
        115                 120                 125             

Leu Gln Ile Lys Gly Lys Asp Tyr Tyr Phe Lys Ser Gly Gly Tyr Leu 
    130                 135                 140                 

Leu Thr Ser Gln Trp Ile Asn Gln Ala Tyr Val Asn Ala Ser Gly Ala 
145                 150                 155                 160 

Lys Val Gln Gln Gly Trp Leu Phe Asp Lys Gln Tyr Gln Ser Trp Phe 
                165                 170                 175     

Tyr Ile Lys Glu Asn Gly Asn Tyr Ala Asp Lys Glu Trp Ile Phe Glu 
            180                 185                 190         

Asn Gly His Tyr Tyr Tyr Leu Lys Ser Gly Gly Tyr Met Ala Ala Asn 
        195                 200                 205             

Glu Trp Ile Trp Asp Lys Glu Ser Trp Phe Tyr Leu Lys Phe Asp Gly 
    210                 215                 220                 

Lys Ile Ala Glu Lys Glu Trp Val Tyr Asp Ser His Ser Gln Ala Trp 
225                 230                 235                 240 

Tyr Tyr Phe Lys Ser Gly Gly Tyr Met Ala Ala Asn Glu Trp Ile Trp 
                245                 250                 255     

Asp Lys Glu Ser Trp Phe Tyr Leu Lys Phe Asp Gly Lys Met Ala Glu 
            260                 265                 270         

Lys Glu Trp Val Tyr Asp Ser His Ser Gln Ala Trp Tyr Tyr Phe Lys 
        275                 280                 285             

Ser Gly Gly Tyr Met Thr Ala Asn Glu Trp Ile Trp Asp Lys Glu Ser 
    290                 295                 300                 

Trp Phe Tyr Leu Lys Ser Asp Gly Lys Ile Ala Glu Lys Glu Trp Val 
305                 310                 315                 320 

Tyr Asp Ser His Ser Gln Ala Trp Tyr Tyr Phe Lys Ser Gly Gly Tyr 
                325                 330                 335     

Met Thr Ala Asn Glu Trp Ile Trp Asp Lys Glu Ser Trp Phe Tyr Leu 
            340                 345                 350         

Lys Ser Asp Gly Lys Met Ala Glu Lys Glu Trp Val Tyr Asp Ser His 
        355                 360                 365             

Ser Gln Ala Trp Tyr Tyr Phe Lys Ser Gly Gly Tyr Met Ala Lys Asn 
    370                 375                 380                 

Glu Thr Val Asp Gly Tyr Gln Leu Gly Ser Asp Gly Lys Trp Leu Gly 
385                 390                 395                 400 

Gly Lys Ala Thr Asn Lys Asn Ala Ala Tyr Tyr Gln Val Val Pro Val 
                405                 410                 415     

Thr Ala Asn Val Tyr Asp Ser Asp Gly Glu Lys Leu Ser Tyr Ile Ser 
            420                 425                 430         

Gln Gly Ser Val Val Trp Leu Asp Lys Asp Arg Lys Ser Asp Asp Lys 
        435                 440                 445             

Arg Leu Ala Ile Thr Ile Ser Gly Leu Ser Gly Tyr Met Lys Thr Glu 
    450                 455                 460                 

Asp Leu Gln Ala Leu Asp Ala Ser Lys Asp Phe Ile Pro Tyr Tyr Glu 
465                 470                 475                 480 

Ser Asp Gly His Arg Phe Tyr His Tyr Val Ala Gln Asn Ala Ser Ile 
                485                 490                 495     

Pro Val Ala Ser His Leu Ser Asp Met Glu Val Gly Lys Lys Tyr Tyr 
            500                 505                 510         

Ser Ala Asp Gly Leu His Phe Asp Gly Phe Lys Leu Glu Asn Pro Phe 
        515                 520                 525             

Leu Phe Lys Asp Leu Thr Glu Ala Thr Asn Tyr Ser Ala Glu Glu Leu 
    530                 535                 540                 

Asp Lys Val Phe Ser Leu Leu Asn Ile Asn Asn Ser Leu Leu Glu Asn 
545                 550                 555                 560 

Lys Gly Ala Thr Phe Lys Glu Ala Glu Glu His Tyr His Ile Asn Ala 
                565                 570                 575     

Leu Tyr Leu Leu Ala His Ser Ala Leu Glu Ser Asn Trp Gly Arg Ser 
            580                 585                 590         

Lys Ile Ala Lys Asp Lys Asn Asn Phe Phe Gly Ile Thr Ala Tyr Asp 
        595                 600                 605             

Thr Thr Pro Tyr Leu Ser Ala Lys Thr Phe Asp Asp Val Asp Lys Gly 
    610                 615                 620                 

Ile Leu Gly Ala Thr Lys Trp Ile Lys Glu Asn Tyr Ile Asp Arg Gly 
625                 630                 635                 640 

Arg Thr Phe Leu Gly Asn Lys Ala Ser Gly Met Asn Val Glu Tyr Ala 
                645                 650                 655     

Ser Asp Pro Tyr Trp Gly Glu Lys Ile Ala Ser Val Met Met Lys Ile 
            660                 665                 670         

Asn Glu Lys Leu Gly Gly Lys Asp 
        675                 680 

<210>   284
<211>   469
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   Fragment of SEQ ID NO: 266, which omits the natural leader peptide sequence

<400>   284
Ala Asn Glu Thr Glu Val Ala Lys Thr Ser Gln Asp Thr Thr Thr Ala 
1               5                   10                  15      

Ser Ser Ser Ser Glu Gln Asn Gln Ser Ser Asn Lys Thr Gln Thr Ser 
            20                  25                  30          

Ala Glu Val Gln Thr Asn Ala Ala Ala Tyr Trp Asp Gly Asp Tyr Tyr 
        35                  40                  45              

Val Lys Asp Asp Gly Ser Lys Ala Gln Ser Glu Trp Ile Phe Asp Asn 
    50                  55                  60                  

Tyr Tyr Lys Ala Trp Phe Tyr Ile Asn Ser Asp Gly Arg Tyr Ser Gln 
65                  70                  75                  80  

Asn Glu Trp His Gly Asn Tyr Tyr Leu Lys Ser Gly Gly Tyr Met Ala 
                85                  90                  95      

Gln Asn Glu Trp Ile Tyr Asp Ser Asn Tyr Lys Ser Trp Phe Tyr Leu 
            100                 105                 110         

Lys Ser Asp Gly Ala Tyr Ala His Gln Glu Trp Gln Leu Ile Gly Asn 
        115                 120                 125             

Lys Trp Tyr Tyr Phe Lys Lys Trp Gly Tyr Met Ala Lys Ser Gln Trp 
    130                 135                 140                 

Gln Gly Ser Tyr Phe Leu Asn Gly Gln Gly Ala Met Ile Gln Asn Glu 
145                 150                 155                 160 

Trp Leu Tyr Asp Pro Ala Tyr Ser Ala Tyr Phe Tyr Leu Lys Ser Asp 
                165                 170                 175     

Gly Thr Tyr Ala Asn Gln Glu Trp Gln Lys Val Gly Gly Lys Trp Tyr 
            180                 185                 190         

Tyr Phe Lys Lys Trp Gly Tyr Met Ala Arg Asn Glu Trp Gln Gly Asn 
        195                 200                 205             

Tyr Tyr Leu Thr Gly Ser Gly Ala Met Ala Thr Asp Glu Val Ile Met 
    210                 215                 220                 

Asp Gly Ala Arg Tyr Ile Phe Ala Ala Ser Gly Glu Leu Lys Glu Lys 
225                 230                 235                 240 

Lys Asp Leu Asn Val Gly Trp Val His Arg Asp Gly Lys Arg Tyr Phe 
                245                 250                 255     

Phe Asn Asn Arg Glu Glu Gln Val Gly Thr Glu His Ala Lys Lys Ile 
            260                 265                 270         

Ile Asp Ile Ser Glu His Asn Gly Arg Ile Asn Asp Trp Lys Lys Val 
        275                 280                 285             

Ile Asp Glu Asn Lys Val Asp Gly Val Ile Val Arg Leu Gly Tyr Ser 
    290                 295                 300                 

Gly Lys Glu Asp Lys Glu Leu Ala His Asn Ile Lys Glu Leu Asn Arg 
305                 310                 315                 320 

Leu Gly Ile Pro Tyr Gly Val Tyr Leu Tyr Thr Tyr Ala Glu Asn Glu 
                325                 330                 335     

Thr Asp Ala Glu Asn Asp Ala Lys Gln Thr Ile Glu Leu Ile Lys Lys 
            340                 345                 350         

Tyr Asn Met Asn Leu Ser Tyr Pro Ile Tyr Tyr Asp Val Glu Asn Trp 
        355                 360                 365             

Glu Tyr Val Asn Lys Ser Lys Arg Ala Pro Ser Asp Thr Asp Thr Trp 
    370                 375                 380                 

Val Lys Ile Ile Asn Lys Tyr Met Asp Thr Met Lys Gln Ala Gly Tyr 
385                 390                 395                 400 

Gln Asn Val Tyr Val Tyr Ser Tyr Arg Ser Leu Leu Gln Thr Arg Leu 
                405                 410                 415     

Lys His Pro Asp Ile Leu Lys His Val Asn Trp Val Ala Ala Tyr Thr 
            420                 425                 430         

Asn Ala Leu Glu Trp Glu Asn Pro Tyr Tyr Ser Gly Glu Lys Gly Trp 
        435                 440                 445             

Gln Tyr Thr Ser Ser Glu Tyr Met Lys Gly Ile Gln Gly Arg Val Asp 
    450                 455                 460                 

Val Ser Val Trp Tyr 
465                 

<210>   285
<211>   471
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   SEQ ID NO: 267, including Pro325 to Leu mutation

<400>   285
Met Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp 
1               5                   10                  15      

Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe 
            20                  25                  30          

Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg 
        35                  40                  45              

Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala 
    50                  55                  60                  

Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
65                  70                  75                  80  

Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
                85                  90                  95      

Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
            100                 105                 110         

Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
        115                 120                 125             

Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
    130                 135                 140                 

Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln 
145                 150                 155                 160 

Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
                165                 170                 175     

Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
            180                 185                 190         

Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
        195                 200                 205             

Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
    210                 215                 220                 

Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val 
225                 230                 235                 240 

Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
                245                 250                 255     

Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val 
            260                 265                 270         

Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys 
        275                 280                 285             

Ala Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr 
    290                 295                 300                 

Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe 
305                 310                 315                 320 

Thr Ala Asp His Leu Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu 
                325                 330                 335     

Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu 
            340                 345                 350         

Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser 
        355                 360                 365             

Gly Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr 
    370                 375                 380                 

Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn 
385                 390                 395                 400 

Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly 
                405                 410                 415     

Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala 
            420                 425                 430         

Trp Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val 
        435                 440                 445             

Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gln Val 
    450                 455                 460                 

Glu Asp Lys Val Glu Asn Asp 
465                 470     

<210>   286
<211>   471
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   SEQ ID NO: 267, which includes Pro325 to Leu and Trp433 to Phe mutations

<400>   286
Met Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp 
1               5                   10                  15      

Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe 
            20                  25                  30          

Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg 
        35                  40                  45              

Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala 
    50                  55                  60                  

Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
65                  70                  75                  80  

Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
                85                  90                  95      

Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
            100                 105                 110         

Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
        115                 120                 125             

Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
    130                 135                 140                 

Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln 
145                 150                 155                 160 

Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
                165                 170                 175     

Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
            180                 185                 190         

Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
        195                 200                 205             

Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
    210                 215                 220                 

Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val 
225                 230                 235                 240 

Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
                245                 250                 255     

Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val 
            260                 265                 270         

Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys 
        275                 280                 285             

Ala Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr 
    290                 295                 300                 

Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe 
305                 310                 315                 320 

Thr Ala Asp His Leu Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu 
                325                 330                 335     

Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu 
            340                 345                 350         

Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser 
        355                 360                 365             

Gly Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr 
    370                 375                 380                 

Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn 
385                 390                 395                 400 

Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly 
                405                 410                 415     

Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala 
            420                 425                 430         

Phe Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val 
        435                 440                 445             

Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gln Val 
    450                 455                 460                 

Glu Asp Lys Val Glu Asn Asp 
465                 470     

<210>   287
<211>   464
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   SEQ ID NO: 267 with Pro325 to Leu mutation with a 7-mer truncation

<400>   287
Met Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp 
1               5                   10                  15      

Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe 
            20                  25                  30          

Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg 
        35                  40                  45              

Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala 
    50                  55                  60                  

Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
65                  70                  75                  80  

Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
                85                  90                  95      

Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
            100                 105                 110         

Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
        115                 120                 125             

Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
    130                 135                 140                 

Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln 
145                 150                 155                 160 

Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
                165                 170                 175     

Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
            180                 185                 190         

Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
        195                 200                 205             

Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
    210                 215                 220                 

Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val 
225                 230                 235                 240 

Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
                245                 250                 255     

Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val 
            260                 265                 270         

Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys 
        275                 280                 285             

Ala Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr 
    290                 295                 300                 

Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe 
305                 310                 315                 320 

Thr Ala Asp His Leu Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu 
                325                 330                 335     

Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu 
            340                 345                 350         

Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser 
        355                 360                 365             

Gly Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr 
    370                 375                 380                 

Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn 
385                 390                 395                 400 

Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly 
                405                 410                 415     

Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala 
            420                 425                 430         

Trp Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val 
        435                 440                 445             

Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gln Val 
    450                 455                 460                 


<210>   288
<211>   366
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   SEQ ID NO: 268 , which omits the natural leader peptide sequence

<400>   288
Ala Glu Thr Thr Asp Asp Lys Ile Ala Ala Gln Asp Asn Lys Ile Ser 
1               5                   10                  15      

Asn Leu Thr Ala Gln Gln Gln Glu Ala Gln Lys Gln Val Asp Gln Ile 
            20                  25                  30          

Gln Glu Gln Val Ser Ala Ile Gln Ala Glu Gln Ser Asn Leu Gln Ala 
        35                  40                  45              

Glu Asn Asp Arg Leu Gln Ala Glu Ser Lys Lys Leu Glu Gly Glu Ile 
    50                  55                  60                  

Thr Glu Leu Ser Lys Asn Ile Val Ser Arg Asn Gln Ser Leu Glu Lys 
65                  70                  75                  80  

Gln Ala Arg Ser Ala Gln Thr Asn Gly Ala Val Thr Ser Tyr Ile Asn 
                85                  90                  95      

Thr Ile Val Asn Ser Lys Ser Ile Thr Glu Ala Ile Ser Arg Val Ala 
            100                 105                 110         

Ala Met Ser Glu Ile Val Ser Ala Asn Asn Lys Met Leu Glu Gln Gln 
        115                 120                 125             

Lys Ala Asp Lys Lys Ala Ile Ser Glu Lys Gln Val Ala Asn Asn Asp 
    130                 135                 140                 

Ala Ile Asn Thr Val Ile Ala Asn Gln Gln Lys Leu Ala Asp Asp Ala 
145                 150                 155                 160 

Gln Ala Leu Thr Thr Lys Gln Ala Glu Leu Lys Ala Ala Glu Leu Ser 
                165                 170                 175     

Leu Ala Ala Glu Lys Ala Thr Ala Glu Gly Glu Lys Ala Ser Leu Leu 
            180                 185                 190         

Glu Gln Lys Ala Ala Ala Glu Ala Glu Ala Arg Ala Ala Ala Val Ala 
        195                 200                 205             

Glu Ala Ala Tyr Lys Glu Lys Arg Ala Ser Gln Gln Gln Ser Val Leu 
    210                 215                 220                 

Ala Ser Ala Asn Thr Asn Leu Thr Ala Gln Val Gln Ala Val Ser Glu 
225                 230                 235                 240 

Ser Ala Ala Ala Pro Val Arg Ala Lys Val Arg Pro Thr Tyr Ser Thr 
                245                 250                 255     

Asn Ala Ser Ser Tyr Pro Ile Gly Glu Cys Thr Trp Gly Val Lys Thr 
            260                 265                 270         

Leu Ala Pro Trp Ala Gly Asp Tyr Trp Gly Asn Gly Ala Gln Trp Ala 
        275                 280                 285             

Thr Ser Ala Ala Ala Ala Gly Phe Arg Thr Gly Ser Thr Pro Gln Val 
    290                 295                 300                 

Gly Ala Ile Ala Cys Trp Asn Asp Gly Gly Tyr Gly His Val Ala Val 
305                 310                 315                 320 

Val Thr Ala Val Glu Ser Thr Thr Arg Ile Gln Val Ser Glu Ser Asn 
                325                 330                 335     

Tyr Ala Gly Asn Arg Thr Ile Gly Asn His Arg Gly Trp Phe Asn Pro 
            340                 345                 350         

Thr Thr Thr Ser Glu Gly Phe Val Thr Tyr Ile Tyr Ala Asp 
        355                 360                 365     

<210>   289
<211>   195
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   variant form of spr0096, with an insert near its C-terminus relative to SEQ ID NO: 269

<400>   289
Met Lys Ser Ile Thr Lys Lys Ile Lys Ala Thr Leu Ala Gly Val Ala 
1               5                   10                  15      

Ala Leu Phe Ala Val Phe Ala Pro Ser Phe Val Ser Ala Gln Glu Ser 
            20                  25                  30          

Ser Thr Tyr Thr Val Lys Glu Gly Asp Thr Leu Ser Glu Ile Ala Glu 
        35                  40                  45              

Thr His Asn Thr Thr Val Glu Lys Leu Ala Glu Asn Asn His Ile Asp 
    50                  55                  60                  

Asn Ile His Leu Ile Tyr Val Asp Gln Glu Leu Val Ile Asp Gly Pro 
65                  70                  75                  80  

Val Ala Pro Val Ala Thr Pro Ala Pro Ala Thr Tyr Ala Ala Pro Ala 
                85                  90                  95      

Ala Gln Asp Glu Thr Val Ser Ala Pro Val Ala Glu Thr Pro Val Val 
            100                 105                 110         

Ser Glu Thr Val Val Ser Thr Val Ser Gly Ser Glu Ala Glu Ala Lys 
        115                 120                 125             

Glu Trp Ile Ala Gln Lys Glu Ser Gly Gly Ser Tyr Thr Ala Thr Asn 
    130                 135                 140                 

Gly Arg Tyr Ile Gly Arg Tyr Gln Leu Thr Asp Ser Tyr Leu Asn Gly 
145                 150                 155                 160 

Asp Tyr Ser Ala Glu Asn Gln Glu Arg Val Ala Asp Ala Tyr Val Ala 
                165                 170                 175     

Gly Arg Tyr Gly Ser Trp Thr Ala Ala Lys Asn Phe Trp Leu Asn Asn 
            180                 185                 190         

Gly Trp Tyr 
        195 

<210>   290
<211>   659
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   variant form of spr1707

<400>   290
Met Lys Lys Asn Arg Val Phe Ala Thr Ala Gly Leu Val Leu Leu Ala 
1               5                   10                  15      

Ala Gly Val Leu Ala Ala Cys Ser Ser Ser Lys Ser Ser Asp Ser Ser 
            20                  25                  30          

Ala Pro Lys Ala Tyr Gly Tyr Val Tyr Thr Ala Asp Pro Glu Thr Leu 
        35                  40                  45              

Asp Tyr Leu Ile Ser Ser Lys Asn Ser Thr Thr Val Val Thr Ser Asn 
    50                  55                  60                  

Gly Ile Asp Gly Leu Phe Thr Asn Asp Asn Tyr Gly Asn Leu Ala Pro 
65                  70                  75                  80  

Ala Val Ala Glu Asp Trp Glu Val Ser Lys Asp Gly Leu Thr Tyr Thr 
                85                  90                  95      

Tyr Lys Ile Arg Lys Gly Val Lys Trp Phe Thr Ser Asp Gly Glu Glu 
            100                 105                 110         

Tyr Ala Glu Val Thr Ala Lys Asp Phe Val Asn Gly Leu Lys His Ala 
        115                 120                 125             

Ala Asp Lys Lys Ser Glu Ala Met Tyr Leu Ala Glu Asn Ser Val Lys 
    130                 135                 140                 

Gly Leu Ala Asp Tyr Leu Ser Gly Thr Ser Thr Asp Phe Ser Thr Val 
145                 150                 155                 160 

Gly Val Lys Ala Val Asp Asp Tyr Thr Leu Gln Tyr Thr Leu Asn Gln 
                165                 170                 175     

Pro Glu Pro Phe Trp Asn Ser Lys Leu Thr Tyr Ser Ile Phe Trp Pro 
            180                 185                 190         

Leu Asn Glu Glu Phe Glu Thr Ser Lys Gly Ser Asp Phe Ala Lys Pro 
        195                 200                 205             

Thr Asp Pro Thr Ser Leu Leu Tyr Asn Gly Pro Phe Leu Leu Lys Gly 
    210                 215                 220                 

Leu Thr Ala Lys Ser Ser Val Glu Phe Val Lys Asn Glu Gln Tyr Trp 
225                 230                 235                 240 

Asp Lys Glu Asn Val His Leu Asp Thr Ile Asn Leu Ala Tyr Tyr Asp 
                245                 250                 255     

Gly Ser Asp Gln Glu Ser Leu Glu Arg Asn Phe Thr Ser Gly Ala Tyr 
            260                 265                 270         

Ser Tyr Ala Arg Leu Tyr Pro Thr Ser Ser Asn Tyr Ser Lys Val Ala 
        275                 280                 285             

Glu Glu Tyr Lys Asp Asn Ile Tyr Tyr Thr Gln Ser Gly Ser Gly Ile 
    290                 295                 300                 

Ala Gly Leu Gly Val Asn Ile Asp Arg Gln Ser Tyr Asn Tyr Thr Ser 
305                 310                 315                 320 

Lys Thr Thr Asp Ser Glu Lys Val Ala Thr Lys Lys Ala Leu Leu Asn 
                325                 330                 335     

Lys Asp Phe Arg Gln Ala Leu Asn Phe Ala Leu Asp Arg Ser Ala Tyr 
            340                 345                 350         

Ser Ala Gln Ile Asn Gly Lys Asp Gly Ala Ala Leu Ala Val Arg Asn 
        355                 360                 365             

Leu Phe Val Lys Pro Asp Phe Val Ser Ala Gly Glu Lys Thr Phe Gly 
    370                 375                 380                 

Asp Leu Val Ala Ala Gln Leu Pro Ala Tyr Gly Asp Glu Trp Lys Gly 
385                 390                 395                 400 

Val Asn Leu Ala Asp Gly Gln Asp Gly Leu Phe Asn Ala Asp Lys Ala 
                405                 410                 415     

Lys Ala Glu Phe Ala Lys Ala Lys Lys Ala Leu Glu Ala Asp Gly Val 
            420                 425                 430         

Gln Phe Pro Ile His Leu Asp Val Pro Val Asp Gln Ala Ser Lys Asn 
        435                 440                 445             

Tyr Ile Ser Arg Ile Gln Ser Phe Lys Gln Ser Val Glu Thr Val Leu 
    450                 455                 460                 

Gly Val Glu Asn Val Val Val Asp Ile Gln Gln Met Thr Ser Asp Glu 
465                 470                 475                 480 

Phe Leu Asn Ile Thr Tyr Tyr Ala Ala Asn Ala Ser Ser Glu Asp Trp 
                485                 490                 495     

Asp Val Ser Gly Gly Val Ser Trp Gly Pro Asp Tyr Gln Asp Pro Ser 
            500                 505                 510         

Thr Tyr Leu Asp Ile Leu Lys Thr Thr Ser Ser Glu Thr Thr Lys Thr 
        515                 520                 525             

Tyr Leu Gly Phe Asp Asn Pro Asn Ser Pro Ser Val Val Gln Val Gly 
    530                 535                 540                 

Leu Lys Glu Tyr Asp Lys Leu Val Asp Glu Ala Ala Arg Glu Thr Ser 
545                 550                 555                 560 

Asp Leu Asn Val Arg Tyr Glu Lys Tyr Ala Ala Ala Gln Ala Trp Leu 
                565                 570                 575     

Thr Asp Ser Ser Leu Phe Ile Pro Ala Met Ala Ser Ser Gly Ala Ala 
            580                 585                 590         

Pro Val Leu Ser Arg Ile Val Pro Phe Thr Gly Ala Ser Ala Gln Thr 
        595                 600                 605             

Gly Ser Lys Gly Ser Asp Val Tyr Phe Lys Tyr Leu Lys Ser Gln Asp 
    610                 615                 620                 

Lys Val Val Thr Lys Glu Glu Tyr Glu Lys Ala Arg Glu Lys Trp Leu 
625                 630                 635                 640 

Lys Glu Lys Ala Glu Ser Asn Glu Lys Ala Gln Lys Glu Leu Ala Ser 
                645                 650                 655     

His Val Lys 
            

<210>   291
<211>   294
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   Fragment of SEQ ID NO: 272, which omits the natural leader peptide sequence

<400>   291
Ala Cys Ser Lys Gly Ser Glu Gly Ala Asp Leu Ile Ser Met Lys Gly 
1               5                   10                  15      

Asp Val Ile Thr Glu His Gln Phe Tyr Glu Gln Val Lys Asn Asn Pro 
            20                  25                  30          

Ser Ala Gln Gln Val Leu Leu Asn Met Thr Ile Gln Lys Val Phe Glu 
        35                  40                  45              

Lys Gln Tyr Gly Ser Glu Leu Asp Asp Lys Glu Val Asp Asp Thr Ile 
    50                  55                  60                  

Ala Glu Glu Lys Lys Gln Tyr Gly Glu Asn Tyr Gln Arg Val Leu Ser 
65                  70                  75                  80  

Gln Ala Gly Met Thr Leu Glu Thr Arg Lys Ala Gln Ile Arg Thr Ser 
                85                  90                  95      

Lys Leu Val Glu Leu Ala Val Lys Lys Val Ala Glu Ala Glu Leu Thr 
            100                 105                 110         

Asp Glu Ala Tyr Lys Lys Ala Phe Asp Glu Tyr Thr Pro Asp Val Thr 
        115                 120                 125             

Ala Gln Ile Ile Arg Leu Asn Asn Glu Asp Lys Ala Lys Glu Val Leu 
    130                 135                 140                 

Glu Lys Ala Lys Ala Glu Gly Ala Asp Phe Ala Gln Leu Ala Lys Asp 
145                 150                 155                 160 

Asn Ser Thr Asp Glu Lys Thr Lys Glu Asn Gly Gly Glu Ile Thr Phe 
                165                 170                 175     

Asp Ser Ala Ser Thr Glu Val Pro Glu Gln Val Lys Lys Ala Ala Phe 
            180                 185                 190         

Ala Leu Asp Val Asp Gly Val Ser Asp Val Ile Thr Ala Thr Gly Thr 
        195                 200                 205             

Gln Ala Tyr Ser Ser Gln Tyr Tyr Ile Val Lys Leu Thr Lys Lys Thr 
    210                 215                 220                 

Glu Lys Ser Ser Asn Ile Asp Asp Tyr Lys Glu Lys Leu Lys Thr Val 
225                 230                 235                 240 

Ile Leu Thr Gln Lys Gln Asn Asp Ser Thr Phe Val Gln Ser Ile Ile 
                245                 250                 255     

Gly Lys Glu Leu Gln Ala Ala Asn Ile Lys Val Lys Asp Gln Ala Phe 
            260                 265                 270         

Gln Asn Ile Phe Thr Gln Tyr Ile Gly Gly Gly Asp Ser Ser Ser Ser 
        275                 280                 285             

Ser Ser Thr Ser Asn Glu 
    290                 

<210>   292
<211>   701
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   spr1995

<400>   292
Met Phe Ala Ser Lys Ser Glu Arg Lys Val His Tyr Ser Ile Arg Lys 
1               5                   10                  15      

Phe Ser Ile Gly Val Ala Ser Val Ala Val Ala Ser Leu Val Met Gly 
            20                  25                  30          

Ser Val Val His Ala Thr Glu Asn Glu Gly Ser Thr Gln Ala Ala Thr 
        35                  40                  45              

Ser Ser Asn Met Ala Lys Thr Glu His Arg Lys Ala Ala Lys Gln Val 
    50                  55                  60                  

Val Asp Glu Tyr Ile Glu Lys Met Leu Arg Glu Ile Gln Leu Asp Arg 
65                  70                  75                  80  

Arg Lys His Thr Gln Asn Val Ala Leu Asn Ile Lys Leu Ser Ala Ile 
                85                  90                  95      

Lys Thr Lys Tyr Leu Arg Glu Leu Asn Val Leu Glu Glu Lys Ser Lys 
            100                 105                 110         

Asp Glu Leu Pro Ser Glu Ile Lys Ala Lys Leu Asp Ala Ala Phe Glu 
        115                 120                 125             

Lys Phe Lys Lys Asp Thr Leu Lys Pro Gly Glu Lys Val Ala Glu Ala 
    130                 135                 140                 

Lys Lys Lys Val Glu Glu Ala Lys Lys Lys Ala Glu Asp Gln Lys Glu 
145                 150                 155                 160 

Glu Asp Arg Arg Asn Tyr Pro Thr Asn Thr Tyr Lys Thr Leu Glu Leu 
                165                 170                 175     

Glu Ile Ala Glu Phe Asp Val Lys Val Lys Glu Ala Glu Leu Glu Leu 
            180                 185                 190         

Val Lys Glu Glu Ala Lys Glu Ser Arg Asn Glu Gly Thr Ile Lys Gln 
        195                 200                 205             

Ala Lys Glu Lys Val Glu Ser Lys Lys Ala Glu Ala Thr Arg Leu Glu 
    210                 215                 220                 

Asn Ile Lys Thr Asp Arg Lys Lys Ala Glu Glu Glu Ala Lys Arg Lys 
225                 230                 235                 240 

Ala Asp Ala Lys Leu Lys Glu Ala Asn Val Ala Thr Ser Asp Gln Gly 
                245                 250                 255     

Lys Pro Lys Gly Arg Ala Lys Arg Gly Val Pro Gly Glu Leu Ala Thr 
            260                 265                 270         

Pro Asp Lys Lys Glu Asn Asp Ala Lys Ser Ser Asp Ser Ser Val Gly 
        275                 280                 285             

Glu Glu Thr Leu Pro Ser Ser Ser Leu Lys Ser Gly Lys Lys Val Ala 
    290                 295                 300                 

Glu Ala Glu Lys Lys Val Glu Glu Ala Glu Lys Lys Ala Lys Asp Gln 
305                 310                 315                 320 

Lys Glu Glu Asp Arg Arg Asn Tyr Pro Thr Asn Thr Tyr Lys Thr Leu 
                325                 330                 335     

Asp Leu Glu Ile Ala Glu Ser Asp Val Lys Val Lys Glu Ala Glu Leu 
            340                 345                 350         

Glu Leu Val Lys Glu Glu Ala Lys Glu Pro Arg Asp Glu Glu Lys Ile 
        355                 360                 365             

Lys Gln Ala Lys Ala Lys Val Glu Ser Lys Lys Ala Glu Ala Thr Arg 
    370                 375                 380                 

Leu Glu Asn Ile Lys Thr Asp Arg Lys Lys Ala Glu Glu Glu Ala Lys 
385                 390                 395                 400 

Arg Lys Ala Ala Glu Glu Asp Lys Val Lys Glu Lys Pro Ala Glu Gln 
                405                 410                 415     

Pro Gln Pro Ala Pro Ala Thr Gln Pro Glu Lys Pro Ala Pro Lys Pro 
            420                 425                 430         

Glu Lys Pro Ala Glu Gln Pro Lys Ala Glu Lys Thr Asp Asp Gln Gln 
        435                 440                 445             

Ala Glu Glu Asp Tyr Ala Arg Arg Ser Glu Glu Glu Tyr Asn Arg Leu 
    450                 455                 460                 

Thr Gln Gln Gln Pro Pro Lys Thr Glu Lys Pro Ala Gln Pro Ser Thr 
465                 470                 475                 480 

Pro Lys Thr Gly Trp Lys Gln Glu Asn Gly Met Trp Tyr Phe Tyr Asn 
                485                 490                 495     

Thr Asp Gly Ser Met Ala Thr Gly Trp Leu Gln Asn Asn Gly Ser Trp 
            500                 505                 510         

Tyr Tyr Leu Asn Ala Asn Gly Ala Met Ala Thr Gly Trp Leu Gln Asn 
        515                 520                 525             

Asn Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Ser Met Ala Thr Gly 
    530                 535                 540                 

Trp Leu Gln Asn Asn Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Ala 
545                 550                 555                 560 

Met Ala Thr Gly Trp Leu Gln Tyr Asn Gly Ser Trp Tyr Tyr Leu Asn 
                565                 570                 575     

Ser Asn Gly Ala Met Ala Thr Gly Trp Leu Gln Tyr Asn Gly Ser Trp 
            580                 585                 590         

Tyr Tyr Leu Asn Ala Asn Gly Asp Met Ala Thr Gly Trp Leu Gln Asn 
        595                 600                 605             

Asn Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Asp Met Ala Thr Gly 
    610                 615                 620                 

Trp Leu Gln Tyr Asn Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Asp 
625                 630                 635                 640 

Met Ala Thr Gly Trp Val Lys Asp Gly Asp Thr Trp Tyr Tyr Leu Glu 
                645                 650                 655     

Ala Ser Gly Ala Met Lys Ala Ser Gln Trp Phe Lys Val Ser Asp Lys 
            660                 665                 670         

Trp Tyr Tyr Val Asn Gly Ser Gly Ala Leu Ala Val Asn Thr Thr Val 
        675                 680                 685             

Asp Gly Tyr Gly Val Asn Ala Asn Gly Glu Trp Val Asn 
    690                 695                 700     

<210>   293
<211>   196
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length ClpP

<400>   293
Met Ile Pro Val Val Ile Glu Gln Thr Ser Arg Gly Glu Arg Ser Tyr 
1               5                   10                  15      

Asp Ile Tyr Ser Arg Leu Leu Lys Asp Arg Ile Ile Met Leu Thr Gly 
            20                  25                  30          

Pro Val Glu Asp Asn Met Ala Asn Ser Val Ile Ala Gln Leu Leu Phe 
        35                  40                  45              

Leu Asp Ala Gln Asp Ser Thr Lys Asp Ile Tyr Leu Tyr Val Asn Thr 
    50                  55                  60                  

Pro Gly Gly Ser Val Ser Ala Gly Leu Ala Ile Val Asp Thr Met Asn 
65                  70                  75                  80  

Phe Ile Lys Ala Asp Val Gln Thr Ile Val Met Gly Met Ala Ala Ser 
                85                  90                  95      

Met Gly Thr Val Ile Ala Ser Ser Gly Ala Lys Gly Lys Arg Phe Met 
            100                 105                 110         

Leu Pro Asn Ala Glu Tyr Met Ile His Gln Pro Met Gly Gly Thr Gly 
        115                 120                 125             

Gly Gly Thr Gln Gln Thr Asp Met Ala Ile Ala Ala Glu His Leu Leu 
    130                 135                 140                 

Lys Thr Arg Asn Thr Leu Glu Lys Ile Leu Ala Glu Asn Ser Gly Gln 
145                 150                 155                 160 

Ser Met Glu Lys Val His Ala Asp Ala Glu Arg Asp Asn Trp Met Ser 
                165                 170                 175     

Ala Gln Glu Thr Leu Glu Tyr Gly Phe Ile Asp Glu Ile Met Ala Asn 
            180                 185                 190         

Asn Ser Leu Asn 
        195     

<210>   294
<211>   318
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length LytA

<400>   294
Met Glu Ile Asn Val Ser Lys Leu Arg Thr Asp Leu Pro Gln Val Gly 
1               5                   10                  15      

Val Gln Pro Tyr Arg Gln Val His Ala His Ser Thr Gly Asn Pro His 
            20                  25                  30          

Ser Thr Val Gln Asn Glu Ala Asp Tyr His Trp Arg Lys Asp Pro Glu 
        35                  40                  45              

Leu Gly Phe Phe Ser His Ile Val Gly Asn Gly Cys Ile Met Gln Val 
    50                  55                  60                  

Gly Pro Val Asp Asn Gly Ala Trp Asp Val Gly Gly Gly Trp Asn Ala 
65                  70                  75                  80  

Glu Thr Tyr Ala Ala Val Glu Leu Ile Glu Ser His Ser Thr Lys Glu 
                85                  90                  95      

Glu Phe Met Thr Asp Tyr Arg Leu Tyr Ile Glu Leu Leu Arg Asn Leu 
            100                 105                 110         

Ala Asp Glu Ala Gly Leu Pro Lys Thr Leu Asp Thr Gly Ser Leu Ala 
        115                 120                 125             

Gly Ile Lys Thr His Glu Tyr Cys Thr Asn Asn Gln Pro Asn Asn His 
    130                 135                 140                 

Ser Asp His Val Asp Pro Tyr Pro Tyr Leu Ala Lys Trp Gly Ile Ser 
145                 150                 155                 160 

Arg Glu Gln Phe Lys His Asp Ile Glu Asn Gly Leu Thr Ile Glu Thr 
                165                 170                 175     

Gly Trp Gln Lys Asn Asp Thr Gly Tyr Trp Tyr Val His Ser Asp Gly 
            180                 185                 190         

Ser Tyr Pro Lys Asp Lys Phe Glu Lys Ile Asn Gly Thr Trp Tyr Tyr 
        195                 200                 205             

Phe Asp Ser Ser Gly Tyr Met Leu Ala Asp Arg Trp Arg Lys His Thr 
    210                 215                 220                 

Asp Gly Asn Trp Tyr Trp Phe Asp Asn Ser Gly Glu Met Ala Thr Gly 
225                 230                 235                 240 

Trp Lys Lys Ile Ala Asp Lys Trp Tyr Tyr Phe Asn Glu Glu Gly Ala 
                245                 250                 255     

Met Lys Thr Gly Trp Val Lys Tyr Lys Asp Thr Trp Tyr Tyr Leu Asp 
            260                 265                 270         

Ala Lys Glu Gly Ala Met Val Ser Asn Ala Phe Ile Gln Ser Ala Asp 
        275                 280                 285             

Gly Thr Gly Trp Tyr Tyr Leu Lys Pro Asp Gly Thr Leu Ala Asp Arg 
    290                 295                 300                 

Pro Glu Phe Thr Val Glu Pro Asp Gly Leu Ile Thr Val Lys 
305                 310                 315             

<210>   295
<211>   828
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length PhtA precursor

<400>   295
Met Gln Leu Glu Ile Ser Asn Arg Lys Arg Val Ser Met Lys Ile Asn 
1               5                   10                  15      

Lys Lys Tyr Leu Val Gly Ser Ala Ala Ala Leu Ile Leu Ser Val Cys 
            20                  25                  30          

Ser Tyr Glu Leu Gly Leu Tyr Gln Ala Arg Thr Val Lys Glu Asn Asn 
        35                  40                  45              

Arg Val Ser Tyr Ile Asp Gly Lys Gln Ala Thr Gln Lys Thr Glu Asn 
    50                  55                  60                  

Leu Thr Pro Asp Glu Val Ser Lys Arg Glu Gly Ile Asn Ala Glu Gln 
65                  70                  75                  80  

Ile Val Ile Lys Ile Thr Asp Gln Gly Tyr Val Thr Ser His Gly Asp 
                85                  90                  95      

His Tyr His Tyr Tyr Asn Gly Lys Val Pro Tyr Asp Ala Ile Phe Ser 
            100                 105                 110         

Glu Glu Leu Leu Met Lys Asp Pro Asn Tyr Lys Leu Lys Asp Glu Asp 
        115                 120                 125             

Ile Val Asn Glu Val Lys Gly Gly Tyr Val Ile Lys Val Asp Gly Lys 
    130                 135                 140                 

Tyr Tyr Val Tyr Leu Lys Asp Ala Ala His Ala Asp Asn Val Arg Thr 
145                 150                 155                 160 

Lys Glu Glu Ile Asn Arg Gln Lys Gln Glu His Ser Gln His Arg Glu 
                165                 170                 175     

Gly Gly Thr Pro Arg Asn Asp Gly Ala Val Ala Leu Ala Arg Ser Gln 
            180                 185                 190         

Gly Arg Tyr Thr Thr Asp Asp Gly Tyr Ile Phe Asn Ala Ser Asp Ile 
        195                 200                 205             

Ile Glu Asp Thr Gly Asp Ala Tyr Ile Val Pro His Gly Asp His Tyr 
    210                 215                 220                 

His Tyr Ile Pro Lys Asn Glu Leu Ser Ala Ser Glu Leu Ala Ala Ala 
225                 230                 235                 240 

Glu Ala Phe Leu Ser Gly Arg Gly Asn Leu Ser Asn Ser Arg Thr Tyr 
                245                 250                 255     

Arg Arg Gln Asn Ser Asp Asn Thr Ser Arg Thr Asn Trp Val Pro Ser 
            260                 265                 270         

Val Ser Asn Pro Gly Thr Thr Asn Thr Asn Thr Ser Asn Asn Ser Asn 
        275                 280                 285             

Thr Asn Ser Gln Ala Ser Gln Ser Asn Asp Ile Asp Ser Leu Leu Lys 
    290                 295                 300                 

Gln Leu Tyr Lys Leu Pro Leu Ser Gln Arg His Val Glu Ser Asp Gly 
305                 310                 315                 320 

Leu Val Phe Asp Pro Ala Gln Ile Thr Ser Arg Thr Ala Arg Gly Val 
                325                 330                 335     

Ala Val Pro His Gly Asp His Tyr His Phe Ile Pro Tyr Ser Gln Met 
            340                 345                 350         

Ser Glu Leu Glu Glu Arg Ile Ala Arg Ile Ile Pro Leu Arg Tyr Arg 
        355                 360                 365             

Ser Asn His Trp Val Pro Asp Ser Arg Pro Glu Gln Pro Ser Pro Gln 
    370                 375                 380                 

Pro Thr Pro Glu Pro Ser Pro Gly Pro Gln Pro Ala Pro Asn Leu Lys 
385                 390                 395                 400 

Ile Asp Ser Asn Ser Ser Leu Val Ser Gln Leu Val Arg Lys Val Gly 
                405                 410                 415     

Glu Gly Tyr Val Phe Glu Glu Lys Gly Ile Ser Arg Tyr Val Phe Ala 
            420                 425                 430         

Lys Asp Leu Pro Ser Glu Thr Val Lys Asn Leu Glu Ser Lys Leu Ser 
        435                 440                 445             

Lys Gln Glu Ser Val Ser His Thr Leu Thr Ala Lys Lys Glu Asn Val 
    450                 455                 460                 

Ala Pro Arg Asp Gln Glu Phe Tyr Asp Lys Ala Tyr Asn Leu Leu Thr 
465                 470                 475                 480 

Glu Ala His Lys Ala Leu Phe Glu Asn Lys Gly Arg Asn Ser Asp Phe 
                485                 490                 495     

Gln Ala Leu Asp Lys Leu Leu Glu Arg Leu Asn Asp Glu Ser Thr Asn 
            500                 505                 510         

Lys Glu Lys Leu Val Asp Asp Leu Leu Ala Phe Leu Ala Pro Ile Thr 
        515                 520                 525             

His Pro Glu Arg Leu Gly Lys Pro Asn Ser Gln Ile Glu Tyr Thr Glu 
    530                 535                 540                 

Asp Glu Val Arg Ile Ala Gln Leu Ala Asp Lys Tyr Thr Thr Ser Asp 
545                 550                 555                 560 

Gly Tyr Ile Phe Asp Glu His Asp Ile Ile Ser Asp Glu Gly Asp Ala 
                565                 570                 575     

Tyr Val Thr Pro His Met Gly His Ser His Trp Ile Gly Lys Asp Ser 
            580                 585                 590         

Leu Ser Asp Lys Glu Lys Val Ala Ala Gln Ala Tyr Thr Lys Glu Lys 
        595                 600                 605             

Gly Ile Leu Pro Pro Ser Pro Asp Ala Asp Val Lys Ala Asn Pro Thr 
    610                 615                 620                 

Gly Asp Ser Ala Ala Ala Ile Tyr Asn Arg Val Lys Gly Glu Lys Arg 
625                 630                 635                 640 

Ile Pro Leu Val Arg Leu Pro Tyr Met Val Glu His Thr Val Glu Val 
                645                 650                 655     

Lys Asn Gly Asn Leu Ile Ile Pro His Lys Asp His Tyr His Asn Ile 
            660                 665                 670         

Lys Phe Ala Trp Phe Asp Asp His Thr Tyr Lys Ala Pro Asn Gly Tyr 
        675                 680                 685             

Thr Leu Glu Asp Leu Phe Ala Thr Ile Lys Tyr Tyr Val Glu His Pro 
    690                 695                 700                 

Asp Glu Arg Pro His Ser Asn Asp Gly Trp Gly Asn Ala Ser Glu His 
705                 710                 715                 720 

Val Leu Gly Lys Lys Asp His Ser Glu Asp Pro Asn Lys Asn Phe Lys 
                725                 730                 735     

Ala Asp Glu Glu Pro Val Glu Glu Thr Pro Ala Glu Pro Glu Val Pro 
            740                 745                 750         

Gln Val Glu Thr Glu Lys Val Glu Ala Gln Leu Lys Glu Ala Glu Val 
        755                 760                 765             

Leu Leu Ala Lys Val Thr Asp Ser Ser Leu Lys Ala Asn Ala Thr Glu 
    770                 775                 780                 

Thr Leu Ala Gly Leu Arg Asn Asn Leu Thr Leu Gln Ile Met Asp Asn 
785                 790                 795                 800 

Asn Ser Ile Met Ala Glu Ala Glu Lys Leu Leu Ala Leu Leu Lys Gly 
                805                 810                 815     

Ser Asn Pro Ser Ser Val Ser Lys Glu Lys Ile Asn 
            820                 825             

<210>   296
<211>   819
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length PhtB precursor

<220>
<221>   misc_feature
<222>   (578) ... (578)
<223>   any amino acid residue; optionally lysine

<400>   296
Met Lys Ile Asn Lys Lys Tyr Leu Ala Gly Ser Val Ala Val Leu Ala 
1               5                   10                  15      

Leu Ser Val Cys Ser Tyr Glu Leu Gly Arg Tyr Gln Ala Gly Gln Asp 
            20                  25                  30          

Lys Lys Glu Ser Asn Arg Val Ala Tyr Ile Asp Gly Asp Gln Ala Gly 
        35                  40                  45              

Gln Lys Ala Glu Asn Leu Thr Pro Asp Glu Val Ser Lys Arg Glu Gly 
    50                  55                  60                  

Ile Asn Ala Glu Gln Ile Val Ile Lys Ile Thr Asp Gln Gly Tyr Val 
65                  70                  75                  80  

Thr Ser His Gly Asp His Tyr His Tyr Tyr Asn Gly Lys Val Pro Tyr 
                85                  90                  95      

Asp Ala Ile Ile Ser Glu Glu Leu Leu Met Lys Asp Pro Asn Tyr Gln 
            100                 105                 110         

Leu Lys Asp Ser Asp Ile Val Asn Glu Ile Lys Gly Gly Tyr Val Ile 
        115                 120                 125             

Lys Val Asn Gly Lys Tyr Tyr Val Tyr Leu Lys Asp Ala Ala His Ala 
    130                 135                 140                 

Asp Asn Ile Arg Thr Lys Glu Glu Ile Lys Arg Gln Lys Gln Glu Arg 
145                 150                 155                 160 

Ser His Asn His Asn Ser Arg Ala Asp Asn Ala Val Ala Ala Ala Arg 
                165                 170                 175     

Ala Gln Gly Arg Tyr Thr Thr Asp Asp Gly Tyr Ile Phe Asn Ala Ser 
            180                 185                 190         

Asp Ile Ile Glu Asp Thr Gly Asp Ala Tyr Ile Val Pro His Gly Asp 
        195                 200                 205             

His Tyr His Tyr Ile Pro Lys Asn Glu Leu Ser Ala Ser Glu Leu Ala 
    210                 215                 220                 

Ala Ala Glu Ala Tyr Trp Asn Gly Lys Gln Gly Ser Arg Pro Ser Ser 
225                 230                 235                 240 

Ser Ser Ser Tyr Asn Ala Asn Pro Ala Gln Pro Arg Leu Ser Glu Asn 
                245                 250                 255     

His Asn Leu Thr Val Thr Pro Thr Tyr His Gln Asn Gln Gly Glu Asn 
            260                 265                 270         

Ile Ser Ser Leu Leu Arg Glu Leu Tyr Ala Lys Pro Leu Ser Glu Arg 
        275                 280                 285             

His Val Glu Ser Asp Gly Leu Ile Phe Asp Pro Ala Gln Ile Thr Ser 
    290                 295                 300                 

Arg Thr Ala Arg Gly Val Ala Val Pro His Gly Asn His Tyr His Phe 
305                 310                 315                 320 

Ile Pro Tyr Glu Gln Met Ser Glu Leu Glu Lys Arg Ile Ala Arg Ile 
                325                 330                 335     

Ile Pro Leu Arg Tyr Arg Ser Asn His Trp Val Pro Asp Ser Arg Pro 
            340                 345                 350         

Glu Glu Pro Ser Pro Gln Pro Thr Pro Glu Pro Ser Pro Ser Pro Gln 
        355                 360                 365             

Pro Ala Pro Ser Asn Pro Ile Asp Gly Lys Leu Val Lys Glu Ala Val 
    370                 375                 380                 

Arg Lys Val Gly Asp Gly Tyr Val Phe Glu Glu Asn Gly Val Ser Arg 
385                 390                 395                 400 

Tyr Ile Pro Ala Lys Asp Leu Ser Ala Glu Thr Ala Ala Gly Ile Asp 
                405                 410                 415     

Ser Lys Leu Ala Lys Gln Glu Ser Leu Ser His Lys Leu Gly Thr Lys 
            420                 425                 430         

Lys Thr Asp Leu Pro Ser Ser Asp Arg Glu Phe Tyr Asn Lys Ala Tyr 
        435                 440                 445             

Asp Leu Leu Ala Arg Ile His Gln Asp Leu Leu Asp Asn Lys Gly Arg 
    450                 455                 460                 

Gln Val Asp Phe Glu Ala Leu Asp Asn Leu Leu Glu Arg Leu Lys Asp 
465                 470                 475                 480 

Val Ser Ser Asp Lys Val Lys Leu Val Glu Asp Ile Leu Ala Phe Leu 
                485                 490                 495     

Ala Pro Ile Arg His Pro Glu Arg Leu Gly Lys Pro Asn Ala Gln Ile 
            500                 505                 510         

Thr Tyr Thr Asp Asp Glu Ile Gln Val Ala Lys Leu Ala Gly Lys Tyr 
        515                 520                 525             

Thr Ala Glu Asp Gly Tyr Ile Phe Asp Pro Arg Asp Ile Thr Ser Asp 
    530                 535                 540                 

Glu Gly Asp Ala Tyr Val Thr Pro His Met Thr His Ser His Trp Ile 
545                 550                 555                 560 

Lys Lys Asp Ser Leu Ser Glu Ala Glu Arg Ala Ala Ala Gln Ala Tyr 
                565                 570                 575     

Ala Xaa Glu Lys Gly Leu Thr Pro Pro Ser Thr Asp His Gln Asp Ser 
            580                 585                 590         

Gly Asn Thr Glu Ala Lys Gly Ala Glu Ala Ile Tyr Asn Arg Val Lys 
        595                 600                 605             

Ala Ala Lys Lys Val Pro Leu Asp Arg Met Pro Tyr Asn Leu Gln Tyr 
    610                 615                 620                 

Thr Val Glu Val Lys Asn Gly Ser Leu Ile Ile Pro His Tyr Asp His 
625                 630                 635                 640 

Tyr His Asn Ile Lys Phe Glu Trp Phe Asp Glu Gly Leu Tyr Glu Ala 
                645                 650                 655     

Pro Lys Gly Tyr Thr Leu Glu Asp Leu Leu Ala Thr Val Lys Tyr Tyr 
            660                 665                 670         

Val Glu His Pro Asn Glu Arg Pro His Ser Asp Asn Gly Phe Gly Asn 
        675                 680                 685             

Ala Ser Asp His Val Gln Arg Asn Lys Asn Gly Gln Ala Asp Thr Asn 
    690                 695                 700                 

Gln Thr Glu Lys Pro Ser Glu Glu Lys Pro Gln Thr Glu Lys Pro Glu 
705                 710                 715                 720 

Glu Glu Thr Pro Arg Glu Glu Lys Pro Gln Ser Glu Lys Pro Glu Ser 
                725                 730                 735     

Pro Lys Pro Thr Glu Glu Pro Glu Glu Ser Pro Glu Glu Ser Glu Glu 
            740                 745                 750         

Pro Gln Val Glu Thr Glu Lys Val Glu Glu Lys Leu Arg Glu Ala Glu 
        755                 760                 765             

Asp Leu Leu Gly Lys Ile Gln Asp Pro Ile Ile Lys Ser Asn Ala Lys 
    770                 775                 780                 

Glu Thr Leu Thr Gly Leu Lys Asn Asn Leu Leu Phe Gly Thr Gln Asp 
785                 790                 795                 800 

Asn Asn Thr Ile Met Ala Glu Ala Glu Lys Leu Leu Ala Leu Leu Lys 
                805                 810                 815     

Glu Ser Lys 
            

<210>   297
<211>   853
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length PhtD precursor

<400>   297
Met Lys Ile Asn Lys Lys Tyr Leu Ala Gly Ser Val Ala Val Leu Ala 
1               5                   10                  15      

Leu Ser Val Cys Ser Tyr Glu Leu Gly Arg His Gln Ala Gly Gln Val 
            20                  25                  30          

Lys Lys Glu Ser Asn Arg Val Ser Tyr Ile Asp Gly Asp Gln Ala Gly 
        35                  40                  45              

Gln Lys Ala Glu Asn Leu Thr Pro Asp Glu Val Ser Lys Arg Glu Gly 
    50                  55                  60                  

Ile Asn Ala Glu Gln Ile Val Ile Lys Ile Thr Asp Gln Gly Tyr Val 
65                  70                  75                  80  

Thr Ser His Gly Asp His Tyr His Tyr Tyr Asn Gly Lys Val Pro Tyr 
                85                  90                  95      

Asp Ala Ile Ile Ser Glu Glu Leu Leu Met Lys Asp Pro Asn Tyr Gln 
            100                 105                 110         

Leu Lys Asp Ser Asp Ile Val Asn Glu Ile Lys Gly Gly Tyr Val Ile 
        115                 120                 125             

Lys Val Asp Gly Lys Tyr Tyr Val Tyr Leu Lys Asp Ala Ala His Ala 
    130                 135                 140                 

Asp Asn Ile Arg Thr Lys Glu Glu Ile Lys Arg Gln Lys Gln Glu Arg 
145                 150                 155                 160 

Ser His Asn His Asn Ser Arg Ala Asp Asn Ala Val Ala Ala Ala Arg 
                165                 170                 175     

Ala Gln Gly Arg Tyr Thr Thr Asp Asp Gly Tyr Ile Phe Asn Ala Ser 
            180                 185                 190         

Asp Ile Ile Glu Asp Thr Gly Asp Ala Tyr Ile Val Pro His Gly Asp 
        195                 200                 205             

His Tyr His Tyr Ile Pro Lys Ser Asp Leu Ser Ala Ser Glu Leu Ala 
    210                 215                 220                 

Ala Ala Gln Ala Tyr Trp Asn Gly Lys Gln Gly Ser Arg Pro Ser Ser 
225                 230                 235                 240 

Ser Ser Ser His Asn Ala Asn Pro Ala Gln Pro Arg Leu Ser Glu Asn 
                245                 250                 255     

His Asn Leu Thr Val Thr Pro Thr Tyr His Gln Asn Gln Gly Glu Asn 
            260                 265                 270         

Ile Ser Ser Leu Leu Arg Glu Leu Tyr Ala Lys Pro Leu Ser Glu Arg 
        275                 280                 285             

His Val Glu Ser Asp Gly Leu Ile Phe Asp Pro Ala Gln Ile Thr Ser 
    290                 295                 300                 

Arg Thr Ala Asn Gly Val Ala Val Pro His Gly Asp His Tyr His Phe 
305                 310                 315                 320 

Ile Pro Tyr Ser Gln Leu Ser Pro Leu Glu Glu Lys Leu Ala Arg Ile 
                325                 330                 335     

Ile Pro Leu Arg Tyr Arg Ser Asn His Trp Val Pro Asp Ser Arg Pro 
            340                 345                 350         

Glu Gln Pro Ser Pro Gln Ser Thr Pro Glu Pro Ser Pro Ser Pro Gln 
        355                 360                 365             

Pro Ala Pro Asn Pro Gln Pro Ala Pro Ser Asn Pro Ile Asp Glu Lys 
    370                 375                 380                 

Leu Val Lys Glu Ala Val Arg Lys Val Gly Asp Gly Tyr Val Phe Glu 
385                 390                 395                 400 

Glu Asn Gly Val Pro Arg Tyr Ile Pro Ala Lys Asp Leu Ser Ala Glu 
                405                 410                 415     

Thr Ala Ala Gly Ile Asp Ser Lys Leu Ala Lys Gln Glu Ser Leu Ser 
            420                 425                 430         

His Lys Leu Gly Ala Lys Lys Thr Asp Leu Pro Ser Ser Asp Arg Glu 
        435                 440                 445             

Phe Tyr Asn Lys Ala Tyr Asp Leu Leu Ala Arg Ile His Gln Asp Leu 
    450                 455                 460                 

Leu Asp Asn Lys Gly Arg Gln Val Asp Phe Glu Ala Leu Asp Asn Leu 
465                 470                 475                 480 

Leu Glu Arg Leu Lys Asp Val Ser Ser Asp Lys Val Lys Leu Val Asp 
                485                 490                 495     

Asp Ile Leu Ala Phe Leu Ala Pro Ile Arg His Pro Glu Arg Leu Gly 
            500                 505                 510         

Lys Pro Asn Ala Gln Ile Thr Tyr Thr Asp Asp Glu Ile Gln Val Ala 
        515                 520                 525             

Lys Leu Ala Gly Lys Tyr Thr Thr Glu Asp Gly Tyr Ile Phe Asp Pro 
    530                 535                 540                 

Arg Asp Ile Thr Ser Asp Glu Gly Asp Ala Tyr Val Thr Pro His Met 
545                 550                 555                 560 

Thr His Ser His Trp Ile Lys Lys Asp Ser Leu Ser Glu Ala Glu Arg 
                565                 570                 575     

Ala Ala Ala Gln Ala Tyr Ala Lys Glu Lys Gly Leu Thr Pro Pro Ser 
            580                 585                 590         

Thr Asp His Gln Asp Ser Gly Asn Thr Glu Ala Lys Gly Ala Glu Ala 
        595                 600                 605             

Ile Tyr Asn Arg Val Lys Ala Ala Lys Lys Val Pro Leu Asp Arg Met 
    610                 615                 620                 

Pro Tyr Asn Leu Gln Tyr Thr Val Glu Val Lys Asn Gly Ser Leu Ile 
625                 630                 635                 640 

Ile Pro His Tyr Asp His Tyr His Asn Ile Lys Phe Glu Trp Phe Asp 
                645                 650                 655     

Glu Gly Leu Tyr Glu Ala Pro Lys Gly Tyr Ser Leu Glu Asp Leu Leu 
            660                 665                 670         

Ala Thr Val Lys Tyr Tyr Val Glu His Pro Asn Glu Arg Pro His Ser 
        675                 680                 685             

Asp Asn Gly Phe Gly Asn Ala Ser Asp His Val Gln Arg Asn Lys Asn 
    690                 695                 700                 

Gly Gln Ala Asp Thr Asn Gln Thr Glu Lys Pro Asn Glu Glu Lys Pro 
705                 710                 715                 720 

Gln Thr Glu Lys Pro Glu Glu Asp Lys Glu His Asp Glu Val Ser Glu 
                725                 730                 735     

Pro Thr His Pro Glu Ser Asp Glu Lys Glu Asn His Val Gly Leu Asn 
            740                 745                 750         

Pro Ser Ala Asp Asn Leu Tyr Lys Pro Ser Thr Asp Thr Glu Glu Thr 
        755                 760                 765             

Glu Glu Glu Ala Glu Asp Thr Thr Asp Glu Ala Glu Ile Pro Gln Val 
    770                 775                 780                 

Glu His Ser Val Ile Asn Ala Lys Ile Ala Glu Ala Glu Ala Leu Leu 
785                 790                 795                 800 

Glu Lys Val Thr Asp Ser Ser Ile Arg Gln Asn Ala Val Glu Thr Leu 
                805                 810                 815     

Thr Gly Leu Lys Ser Ser Leu Leu Leu Gly Thr Lys Asp Asn Asn Thr 
            820                 825                 830         

Ile Ser Ala Glu Val Asp Ser Leu Leu Ala Leu Leu Lys Glu Ser Gln 
        835                 840                 845             

Pro Thr Pro Ile Gln 
    850             

<210>   298
<211>   1039
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length PhtE precursor

<400>   298
Met Lys Phe Ser Lys Lys Tyr Ile Ala Ala Gly Ser Ala Val Ile Val 
1               5                   10                  15      

Ser Leu Ser Leu Cys Ala Tyr Ala Leu Asn Gln His Arg Ser Gln Glu 
            20                  25                  30          

Asn Lys Asp Asn Asn Arg Val Ser Tyr Val Asp Gly Ser Gln Ser Ser 
        35                  40                  45              

Gln Lys Ser Glu Asn Leu Thr Pro Asp Gln Val Ser Gln Lys Glu Gly 
    50                  55                  60                  

Ile Gln Ala Glu Gln Ile Val Ile Lys Ile Thr Asp Gln Gly Tyr Val 
65                  70                  75                  80  

Thr Ser His Gly Asp His Tyr His Tyr Tyr Asn Gly Lys Val Pro Tyr 
                85                  90                  95      

Asp Ala Leu Phe Ser Glu Glu Leu Leu Met Lys Asp Pro Asn Tyr Gln 
            100                 105                 110         

Leu Lys Asp Ala Asp Ile Val Asn Glu Val Lys Gly Gly Tyr Ile Ile 
        115                 120                 125             

Lys Val Asp Gly Lys Tyr Tyr Val Tyr Leu Lys Asp Ala Ala His Ala 
    130                 135                 140                 

Asp Asn Val Arg Thr Lys Asp Glu Ile Asn Arg Gln Lys Gln Glu His 
145                 150                 155                 160 

Val Lys Asp Asn Glu Lys Val Asn Ser Asn Val Ala Val Ala Arg Ser 
                165                 170                 175     

Gln Gly Arg Tyr Thr Thr Asn Asp Gly Tyr Val Phe Asn Pro Ala Asp 
            180                 185                 190         

Ile Ile Glu Asp Thr Gly Asn Ala Tyr Ile Val Pro His Gly Gly His 
        195                 200                 205             

Tyr His Tyr Ile Pro Lys Ser Asp Leu Ser Ala Ser Glu Leu Ala Ala 
    210                 215                 220                 

Ala Lys Ala His Leu Ala Gly Lys Asn Met Gln Pro Ser Gln Leu Ser 
225                 230                 235                 240 

Tyr Ser Ser Thr Ala Ser Asp Asn Asn Thr Gln Ser Val Ala Lys Gly 
                245                 250                 255     

Ser Thr Ser Lys Pro Ala Asn Lys Ser Glu Asn Leu Gln Ser Leu Leu 
            260                 265                 270         

Lys Glu Leu Tyr Asp Ser Pro Ser Ala Gln Arg Tyr Ser Glu Ser Asp 
        275                 280                 285             

Gly Leu Val Phe Asp Pro Ala Lys Ile Ile Ser Arg Thr Pro Asn Gly 
    290                 295                 300                 

Val Ala Ile Pro His Gly Asp His Tyr His Phe Ile Pro Tyr Ser Lys 
305                 310                 315                 320 

Leu Ser Ala Leu Glu Glu Lys Ile Ala Arg Arg Val Pro Ile Ser Gly 
                325                 330                 335     

Thr Gly Ser Thr Val Ser Thr Asn Ala Lys Pro Asn Glu Val Val Ser 
            340                 345                 350         

Ser Leu Gly Ser Leu Ser Ser Asn Pro Ser Ser Leu Thr Thr Ser Lys 
        355                 360                 365             

Glu Leu Ser Ser Ala Ser Asp Gly Tyr Ile Phe Asn Pro Lys Asp Ile 
    370                 375                 380                 

Val Glu Glu Thr Ala Thr Ala Tyr Ile Val Arg His Gly Asp His Phe 
385                 390                 395                 400 

His Tyr Ile Pro Lys Ser Asn Gln Ile Gly Gln Pro Thr Leu Pro Asn 
                405                 410                 415     

Asn Ser Leu Ala Thr Pro Ser Pro Ser Leu Pro Ile Asn Pro Gly Ile 
            420                 425                 430         

Ser His Glu Lys His Glu Glu Asp Gly Tyr Gly Phe Asp Ala Asn Arg 
        435                 440                 445             

Ile Ile Ala Glu Asp Glu Ser Gly Phe Ile Met Ser His Gly Asn His 
    450                 455                 460                 

Asn His Tyr Phe Phe Lys Lys Asp Leu Thr Glu Glu Gln Ile Lys Ala 
465                 470                 475                 480 

Ala Gln Lys His Leu Glu Glu Val Lys Thr Ser His Asn Gly Leu Asp 
                485                 490                 495     

Ser Leu Ser Ser His Glu Gln Asp Tyr Pro Gly Asn Ala Lys Glu Met 
            500                 505                 510         

Lys Asp Leu Asp Lys Lys Ile Glu Glu Lys Ile Ala Gly Ile Met Lys 
        515                 520                 525             

Gln Tyr Gly Val Lys Arg Glu Ser Ile Val Val Asn Lys Glu Lys Asn 
    530                 535                 540                 

Ala Ile Ile Tyr Pro His Gly Asp His His His Ala Asp Pro Ile Asp 
545                 550                 555                 560 

Glu His Lys Pro Val Gly Ile Gly His Ser His Ser Asn Tyr Glu Leu 
                565                 570                 575     

Phe Lys Pro Glu Glu Gly Val Ala Lys Lys Glu Gly Asn Lys Val Tyr 
            580                 585                 590         

Thr Gly Glu Glu Leu Thr Asn Val Val Asn Leu Leu Lys Asn Ser Thr 
        595                 600                 605             

Phe Asn Asn Gln Asn Phe Thr Leu Ala Asn Gly Gln Lys Arg Val Ser 
    610                 615                 620                 

Phe Ser Phe Pro Pro Glu Leu Glu Lys Lys Leu Gly Ile Asn Met Leu 
625                 630                 635                 640 

Val Lys Leu Ile Thr Pro Asp Gly Lys Val Leu Glu Lys Val Ser Gly 
                645                 650                 655     

Lys Val Phe Gly Glu Gly Val Gly Asn Ile Ala Asn Phe Glu Leu Asp 
            660                 665                 670         

Gln Pro Tyr Leu Pro Gly Gln Thr Phe Lys Tyr Thr Ile Ala Ser Lys 
        675                 680                 685             

Asp Tyr Pro Glu Val Ser Tyr Asp Gly Thr Phe Thr Val Pro Thr Ser 
    690                 695                 700                 

Leu Ala Tyr Lys Met Ala Ser Gln Thr Ile Phe Tyr Pro Phe His Ala 
705                 710                 715                 720 

Gly Asp Thr Tyr Leu Arg Val Asn Pro Gln Phe Ala Val Pro Lys Gly 
                725                 730                 735     

Thr Asp Ala Leu Val Arg Val Phe Asp Glu Phe His Gly Asn Ala Tyr 
            740                 745                 750         

Leu Glu Asn Asn Tyr Lys Val Gly Glu Ile Lys Leu Pro Ile Pro Lys 
        755                 760                 765             

Leu Asn Gln Gly Thr Thr Arg Thr Ala Gly Asn Lys Ile Pro Val Thr 
    770                 775                 780                 

Phe Met Ala Asn Ala Tyr Leu Asp Asn Gln Ser Thr Tyr Ile Val Glu 
785                 790                 795                 800 

Val Pro Ile Leu Glu Lys Glu Asn Gln Thr Asp Lys Pro Ser Ile Leu 
                805                 810                 815     

Pro Gln Phe Lys Arg Asn Lys Ala Gln Glu Asn Ser Lys Leu Asp Glu 
            820                 825                 830         

Lys Val Glu Glu Pro Lys Thr Ser Glu Lys Val Glu Lys Glu Lys Leu 
        835                 840                 845             

Ser Glu Thr Gly Asn Ser Thr Ser Asn Ser Thr Leu Glu Glu Val Pro 
    850                 855                 860                 

Thr Val Asp Pro Val Gln Glu Lys Val Ala Lys Phe Ala Glu Ser Tyr 
865                 870                 875                 880 

Gly Met Lys Leu Glu Asn Val Leu Phe Asn Met Asp Gly Thr Ile Glu 
                885                 890                 895     

Leu Tyr Leu Pro Ser Gly Glu Val Ile Lys Lys Asn Met Ala Asp Phe 
            900                 905                 910         

Thr Gly Glu Ala Pro Gln Gly Asn Gly Glu Asn Lys Pro Ser Glu Asn 
        915                 920                 925             

Gly Lys Val Ser Thr Gly Thr Val Glu Asn Gln Pro Thr Glu Asn Lys 
    930                 935                 940                 

Pro Ala Asp Ser Leu Pro Glu Ala Pro Asn Glu Lys Pro Val Lys Pro 
945                 950                 955                 960 

Glu Asn Ser Thr Asp Asn Gly Met Leu Asn Pro Glu Gly Asn Val Gly 
                965                 970                 975     

Ser Asp Pro Met Leu Asp Pro Ala Leu Glu Glu Ala Pro Ala Val Asp 
            980                 985                 990         

Pro Val Gln Glu Lys Leu Glu Lys Phe Thr Ala Ser Tyr Gly Leu Gly 
        995                 1000                1005            

Leu Asp Ser Val Ile Phe Asn Met Asp Gly Thr Ile Glu Leu Arg Leu 
    1010                1015                1020                

Pro Ser Gly Glu Val Ile Lys Lys Asn Leu Ser Asp Leu Ile Ala 
1025                1030                1035                

<210>   299
<211>   1876
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length ZmpB

<400>   299
Met Phe Lys Lys Asp Arg Phe Ser Ile Arg Lys Ile Lys Gly Val Val 
1               5                   10                  15      

Gly Ser Val Phe Leu Gly Ser Leu Leu Met Ala Pro Ser Val Val Asp 
            20                  25                  30          

Ala Ala Thr Tyr His Tyr Val Asn Lys Glu Ile Ile Ser Gln Glu Ala 
        35                  40                  45              

Lys Asp Leu Ile Gln Thr Gly Lys Pro Asp Arg Asn Glu Val Val Tyr 
    50                  55                  60                  

Gly Leu Val Tyr Gln Lys Asp Gln Leu Pro Gln Thr Gly Thr Glu Ala 
65                  70                  75                  80  

Ser Val Leu Thr Ala Phe Gly Leu Leu Thr Val Gly Ser Leu Leu Leu 
                85                  90                  95      

Ile Tyr Lys Arg Lys Lys Ile Ala Ser Val Phe Leu Val Gly Thr Met 
            100                 105                 110         

Gly Leu Val Val Leu Pro Ser Ala Gly Ala Val Asp Pro Val Ala Thr 
        115                 120                 125             

Leu Ala Leu Ala Ser Arg Glu Gly Val Val Glu Met Glu Gly Tyr Arg 
    130                 135                 140                 

Tyr Val Gly Tyr Leu Ser Gly Asp Ile Leu Lys Thr Leu Gly Leu Asp 
145                 150                 155                 160 

Thr Val Leu Glu Glu Thr Ser Ala Lys Pro Gly Glu Val Thr Val Val 
                165                 170                 175     

Glu Val Glu Thr Pro Gln Ser Thr Thr Asn Gln Glu Gln Ala Arg Thr 
            180                 185                 190         

Glu Asn Gln Val Val Glu Thr Glu Glu Ala Pro Lys Glu Glu Ala Pro 
        195                 200                 205             

Lys Thr Glu Glu Ser Pro Lys Glu Glu Pro Lys Ser Glu Val Lys Pro 
    210                 215                 220                 

Thr Asp Asp Thr Leu Pro Lys Val Glu Glu Gly Lys Glu Asp Ser Ala 
225                 230                 235                 240 

Glu Pro Ala Pro Val Glu Glu Val Gly Gly Glu Val Glu Ser Lys Pro 
                245                 250                 255     

Glu Glu Lys Val Ala Val Lys Pro Glu Ser Gln Pro Ser Asp Lys Pro 
            260                 265                 270         

Ala Glu Glu Ser Lys Val Glu Gln Ala Gly Glu Pro Val Ala Pro Arg 
        275                 280                 285             

Lys Asp Glu Gln Ala Pro Val Glu Pro Glu Asn Gln Pro Glu Ala Pro 
    290                 295                 300                 

Glu Glu Glu Lys Ala Val Glu Glu Thr Pro Lys Gln Glu Glu Ser Thr 
305                 310                 315                 320 

Pro Asp Thr Lys Ala Glu Glu Thr Val Glu Pro Lys Glu Glu Thr Lys 
                325                 330                 335     

Thr Ala Lys Gly Thr Gln Glu Glu Gly Lys Glu Gly Gln Ala Pro Val 
            340                 345                 350         

Gln Glu Val Asn Pro Glu Tyr Lys Val Thr Thr Gly Thr Val Glu Lys 
        355                 360                 365             

Ser Thr Glu Ser Glu Leu Asp Phe Thr Thr Glu Val Val Pro Asp Asp 
    370                 375                 380                 

Thr Lys Tyr Val Asp Glu Glu Val Val Glu Arg Gln Gly Ser Lys Gly 
385                 390                 395                 400 

Val Gln Val Thr Lys Thr Thr Tyr Glu Thr Val Glu Val Val Glu Thr 
                405                 410                 415     

Asp Lys Val Leu Ser Thr Thr Thr Glu Val Lys Thr Pro Val Val Pro 
            420                 425                 430         

Lys Val Val Lys Lys Gly Thr Lys Pro Val Glu Thr Arg Glu Glu Val 
        435                 440                 445             

Ile Pro Phe Ala Thr Lys Glu Gln Glu Asp Asp Thr Leu Lys Arg Gly 
    450                 455                 460                 

Thr Arg Gln Val Ala Gln Glu Gly Val Asn Gly Lys Lys Gln Ile Thr 
465                 470                 475                 480 

Glu Thr Tyr Lys Thr Ile Arg Gly Glu Lys Thr Asn Glu Ala Pro Thr 
                485                 490                 495     

Val Glu Glu Thr Val Leu Gln Ala Pro Gln Asp Glu Ile Ile Lys Lys 
            500                 505                 510         

Gly Thr Lys Gly Leu Glu Lys Pro Thr Leu Gln Trp Ala Asn Thr Glu 
        515                 520                 525             

Lys Asp Val Leu Lys Lys Ser Ala Thr Ala Ser Tyr Thr Leu Thr Lys 
    530                 535                 540                 

Pro Ala Gly Val Glu Ile Lys Ser Ile Lys Leu Ala Leu Lys Asp Lys 
545                 550                 555                 560 

Asp Gly Gln Leu Val Lys Glu Val Thr Val Ala Glu Asn Asn Leu Asn 
                565                 570                 575     

Ala Thr Leu Asp Lys Leu Lys Tyr Tyr Gln Gly Tyr Thr Leu Ser Thr 
            580                 585                 590         

Thr Met Val Tyr Asp Arg Gly Glu Gly Glu Glu Thr Glu Lys Leu Glu 
        595                 600                 605             

Asp Lys Gln Ile Gln Leu Asp Leu Lys Lys Val Glu Ile Lys Asn Ile 
    610                 615                 620                 

Lys Glu Thr Ser Leu Met Asn Val Asp Ala Glu Gly Asn Glu Thr Asp 
625                 630                 635                 640 

Lys Ser Leu Leu Ser Glu Lys Pro Thr Asp Val Ser Gln Leu Tyr Leu 
                645                 650                 655     

Arg Val Thr Thr His Asp Asn Lys Val Thr Arg Leu Ala Val Ser Ser 
            660                 665                 670         

Val Glu Glu Val Val Val Asp Gly Lys Thr Leu Tyr Lys Val Val Ala 
        675                 680                 685             

Lys Ala Pro Asp Leu Val Gln Arg Arg Ala Asp Asp Thr Leu Ser Glu 
    690                 695                 700                 

Glu Tyr Val His Tyr Phe Glu Lys Gln Leu Pro Lys Val Asn Asn Val 
705                 710                 715                 720 

Tyr Tyr Asn Phe Asn Glu Leu Val Lys Asp Met Gln Ala Asn Pro Met 
                725                 730                 735     

Gly Glu Phe Lys Leu Gly Ala Asp Leu Asn Ala Val Asn Val Lys Pro 
            740                 745                 750         

Ala Gly Lys Ala Tyr Val Met Ala Lys Phe Arg Gly Thr Leu Ser Ser 
        755                 760                 765             

Val Glu Asn His Gln Tyr Thr Ile His Asn Leu Glu Arg Pro Leu Phe 
    770                 775                 780                 

Asn Glu Ala Glu Gly Ala Thr Leu Lys Asn Phe Asn Leu Gly Asn Val 
785                 790                 795                 800 

Asn Ile Asn Met Pro Trp Ala Asp Lys Val Ala Pro Ile Gly Asn Met 
                805                 810                 815     

Phe Lys Lys Ser Thr Leu Glu Asn Ile Lys Val Val Gly Ser Val Thr 
            820                 825                 830         

Gly Asn Asn Asp Val Thr Gly Ala Val Asn Lys Leu Asp Glu Ala Asn 
        835                 840                 845             

Met Arg Asn Val Ala Phe Ile Gly Lys Ile Asn Ser Leu Gly Asp Lys 
    850                 855                 860                 

Gly Trp Trp Ser Gly Gly Leu Val Ser Glu Ser Trp Arg Ser Asn Thr 
865                 870                 875                 880 

Asp Ser Val Tyr Phe Asp Gly Asp Ile Val Gly Asn Asn Ser Lys Phe 
                885                 890                 895     

Gly Gly Leu Val Ala Lys Val Asn His Gly Ser Asn Gln Trp Asp Val 
            900                 905                 910         

Lys Gln Lys Gly Arg Leu Thr Asn Ser Val Val Lys Gly Thr Met Thr 
        915                 920                 925             

Leu Lys Asn His Gly Gln Ser Gly Gly Leu Val His Glu Asn Tyr Asp 
    930                 935                 940                 

Trp Gly Trp Val Glu Asn Asn Ile Ser Met Met Lys Val Asn Asn Gly 
945                 950                 955                 960 

Glu Ile Met Tyr Gly Ser Gly Ser Ile Asp Gly Asp Pro Tyr Phe Gly 
                965                 970                 975     

Phe Asp Tyr Phe Lys Asn Asn Tyr Tyr Val Lys Asp Val Ala Thr Gly 
            980                 985                 990         

Glu Ser Thr Tyr Lys Arg Ser Lys Gln Ile Gln Ser Ile Ser Gln Ala 
        995                 1000                1005            

Glu Ala Asp Ala Lys Ile Ala Asn Met Gly Ile Thr Ala Asn Thr Phe 
    1010                1015                1020                

Ala Ile Gln Asp Pro Val Val Asn Lys Leu Asn Arg Ile Ile Asp Arg 
1025                1030                1035                1040

Asp Ser Glu Tyr Lys Ala Ile Gln Asp Tyr Gln Glu Thr Arg Asn Leu 
                1045                1050                1055    

Ala Tyr Arg Asn Leu Glu Lys Leu Gln Pro Phe Tyr Asn Lys Glu Trp 
            1060                1065                1070        

Ile Val Asn Gln Gly Asn Lys Leu Thr Asp Glu Ser Asn Leu Val Lys 
        1075                1080                1085            

Lys Thr Val Leu Ser Val Thr Gly Met Lys Ser Gly Gln Phe Val Thr 
    1090                1095                1100                

Asp Leu Ser Ser Val Asp Lys Ile Met Ile His Tyr Ala Asp Gly Thr 
1105                1110                1115                1120

Lys Glu Glu Phe Gly Val Ser Ala Ile Ser Asp Ser Arg Val Lys Gln 
                1125                1130                1135    

Val Lys Glu Tyr Asn Val Asp Asp Leu Gly Val Val Tyr Thr Pro Asn 
            1140                1145                1150        

Met Val Asp Lys Asn Arg Asp Ser Leu Ile Thr Lys Val Lys Glu Lys 
        1155                1160                1165            

Leu Ser Ser Val Ala Leu Asp Ser Ala Glu Val Lys Ser Ile Thr Asn 
    1170                1175                1180                

Asn Pro Ala Ser Leu Tyr Leu Glu Glu Ser Phe Ala Glu Val Arg Glu 
1185                1190                1195                1200

Thr Leu Asp Lys Leu Val Lys Ser Leu Leu Glu Asn Glu Asp His Gln 
                1205                1210                1215    

Leu Asn Ser Asp Glu Val Ala Glu Lys Ala Leu Leu Lys Lys Val Glu 
            1220                1225                1230        

Asp Asn Lys Ala Lys Ile Ile Leu Ala Leu Thr Tyr Leu Asn Arg Tyr 
        1235                1240                1245            

Tyr Gly Ile Asp Tyr Asp Gly Leu Asn Phe Lys His Leu Met Met Phe 
    1250                1255                1260                

Lys Pro Asp Phe Tyr Gly Lys Thr Pro Ser Ile Leu Asp Phe Leu Ile 
1265                1270                1275                1280

Arg Ile Gly Ser Ala Glu Lys Asn Leu Lys Gly Asp Arg Ser Leu Glu 
                1285                1290                1295    

Ala Tyr Arg Glu Val Ile Gly Gly Thr Ile Gly Lys Gly Glu Leu Asn 
            1300                1305                1310        

Gly Leu Leu Gly Tyr Asn Met Arg Leu Phe Thr Lys Tyr Thr Asp Leu 
        1315                1320                1325            

Asn Asp Trp Phe Ile His Ala Ala Lys Asn Val Tyr Val Ser Glu Pro 
    1330                1335                1340                

Glu Thr Thr Thr Glu Asp Phe Lys Asp Lys Arg His Arg Ile Tyr Asp 
1345                1350                1355                1360

Gly Leu Asn Asn Asp Val His Gly Arg Met Ile Leu Pro Leu Leu Asn 
                1365                1370                1375    

Leu Lys Lys Ala His Ile Phe Val Ile Ser Thr Tyr Asn Thr Ile Ala 
            1380                1385                1390        

Phe Ser Ser Phe Glu Lys Tyr Gly Lys Asn Thr Glu Glu Glu Arg Asn 
        1395                1400                1405            

Ala Tyr Lys Ala Glu Ile Asp Arg Val Ala Lys Ala Gln Gln Arg Tyr 
    1410                1415                1420                

Leu Asp Phe Trp Ser Arg Leu Ala Leu Pro Lys Val Arg Asn Gln Leu 
1425                1430                1435                1440

Leu Lys Ser Gln Asn Ser Val Pro Thr Pro Val Trp Asp Asn Gln Val 
                1445                1450                1455    

Tyr Val Gly Leu Gly Gly Ala Asn Arg Met Gly Tyr Gly Asp Gly Gly 
            1460                1465                1470        

Arg Val Val Thr Pro Val Arg Glu Leu Phe Gly Pro Thr Asp Arg Trp 
        1475                1480                1485            

His Gln Ile Asn Trp Asn Met Gly Ala Met Ala Lys Ile Tyr Glu Arg 
    1490                1495                1500                

Pro Trp Lys Asp Asp Gln Val Tyr Phe Met Val Thr Asn Met Met Glu 
1505                1510                1515                1520

Pro Phe Gly Ile Ser Ala Phe Thr His Glu Thr Thr His Val Asn Asp 
                1525                1530                1535    

Arg Met Ala Tyr Tyr Gly Gly Asp Trp His Arg Glu Gly Thr Asp Leu 
            1540                1545                1550        

Glu Ala Phe Ala Gln Gly Met Leu Gln Thr Pro Asp Lys Ser Thr Thr 
        1555                1560                1565            

Asn Gly Glu Tyr Gly Ala Leu Gly Ile Asn Met Ala Tyr Glu Arg Lys 
    1570                1575                1580                

Asn Asp Gly Glu Gln Leu Tyr Asn Tyr Asp Pro Glu Lys Leu Asp Ser 
1585                1590                1595                1600

Arg Glu Lys Ile Asp Ser Tyr Met Lys Asn Tyr Asn Glu Ser Met Met 
                1605                1610                1615    

Met Leu Asp Tyr Leu Glu Ala Ser Ala Val Ile Arg Gln Asn Leu Ser 
            1620                1625                1630        

Asp Asn Ser Lys Trp Phe Lys Lys Met Asp Lys Glu Trp Arg Thr Asn 
        1635                1640                1645            

Ala Asp Arg Asn Arg Leu Ile Gly Glu Pro His Gln Trp Asp Lys Leu 
    1650                1655                1660                

Arg Asp Leu Thr Glu Glu Glu Lys Lys Leu Pro Ile Asp Ser Ile Asp 
1665                1670                1675                1680

Lys Leu Val Glu Asn Asn Phe Val Thr Leu His Gly Met Pro Lys Asn 
                1685                1690                1695    

Gly Arg Tyr Arg Thr Glu Gly Phe Asp Ser Ser Tyr Gln Pro Val Asn 
            1700                1705                1710        

Met Met Ala Gly Val Phe Gly Gly Asn Thr Ser Lys Ser Thr Val Gly 
        1715                1720                1725            

Ser Ile Ser Phe Lys His Asn Ala Phe Arg Met Trp Gly Tyr Tyr Gly 
    1730                1735                1740                

Tyr Glu Asn Gly Phe Ile Pro Tyr Val Ser Asn Lys Leu Lys Gly Ala 
1745                1750                1755                1760

Ala Asn Lys Glu Asn Lys Gly Leu Leu Gly Asp Asp Phe Ile Ile Lys 
                1765                1770                1775    

Lys Val Ser Lys Asn Gln Phe Gln Asn Leu Glu Glu Trp Lys Lys His 
            1780                1785                1790        

Trp Tyr His Glu Val Tyr Asp Lys Ala Gln Lys Gly Phe Val Glu Ile 
        1795                1800                1805            

Glu Val Asp Gly Val Lys Ile Ser Thr Tyr Ala Gln Leu Gln Ser Leu 
    1810                1815                1820                

Phe Glu Glu Ala Val Ser Lys Asp Leu Ala Gly Met Asp Asp Lys Asn 
1825                1830                1835                1840

Ile Lys Asn His Tyr Gln Tyr Thr Glu Asn Leu Lys Trp Lys Ile Tyr 
                1845                1850                1855    

Lys Gln Leu Leu Lys Asn Thr Asp Gly Phe Ser Ser Asp Leu Phe Thr 
            1860                1865                1870        

Ala Pro Gln Ala 
        1875    

<210>   300
<211>   448
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length CbpD

<400>   300
Met Lys Ile Leu Pro Phe Ile Ala Arg Gly Thr Ser Tyr Tyr Leu Lys 
1               5                   10                  15      

Met Ser Val Lys Lys Leu Val Pro Phe Leu Val Val Gly Leu Met Leu 
            20                  25                  30          

Ala Ala Gly Asp Ser Val Tyr Ala Tyr Ser Arg Gly Asn Gly Ser Ile 
        35                  40                  45              

Ala Arg Gly Asp Asp Tyr Pro Ala Tyr Tyr Lys Asn Gly Ser Gln Glu 
    50                  55                  60                  

Ile Asp Gln Trp Arg Met Tyr Ser Arg Gln Cys Thr Ser Phe Val Ala 
65                  70                  75                  80  

Phe Arg Leu Ser Asn Val Asn Gly Phe Glu Ile Pro Ala Ala Tyr Gly 
                85                  90                  95      

Asn Ala Asn Glu Trp Gly His Arg Ala Arg Arg Glu Gly Tyr Arg Val 
            100                 105                 110         

Asp Asn Thr Pro Thr Ile Gly Ser Ile Thr Trp Ser Thr Ala Gly Thr 
        115                 120                 125             

Tyr Gly His Val Ala Trp Val Ser Asn Val Met Gly Asp Gln Ile Glu 
    130                 135                 140                 

Ile Glu Glu Tyr Asn Tyr Gly Tyr Thr Glu Ser Tyr Asn Lys Arg Val 
145                 150                 155                 160 

Ile Lys Ala Asn Thr Met Thr Gly Phe Ile His Phe Lys Asp Leu Asp 
                165                 170                 175     

Ser Gly Ser Val Gly Asn Ser Gln Ser Ser Ala Ser Thr Gly Gly Thr 
            180                 185                 190         

His Tyr Phe Lys Thr Lys Ser Ala Ile Lys Thr Glu Pro Leu Val Ser 
        195                 200                 205             

Ala Thr Val Ile Asp Tyr Tyr Tyr Pro Gly Glu Lys Val His Tyr Asp 
    210                 215                 220                 

Gln Ile Leu Glu Lys Asp Gly Tyr Lys Trp Leu Ser Tyr Thr Ala Tyr 
225                 230                 235                 240 

Asn Gly Ser Tyr Arg Tyr Val Gln Leu Glu Ala Val Asn Lys Asn Pro 
                245                 250                 255     

Leu Gly Asn Ser Val Leu Ser Ser Thr Gly Gly Thr His Tyr Phe Lys 
            260                 265                 270         

Ile Lys Ser Ala Ile Lys Thr Glu Pro Leu Val Ser Ala Thr Val Ile 
        275                 280                 285             

Asp Tyr Tyr Tyr Pro Gly Glu Lys Val His Tyr Asp Gln Ile Leu Glu 
    290                 295                 300                 

Lys Asp Gly Tyr Lys Trp Leu Ser Tyr Thr Ala Tyr Asn Gly Ser Arg 
305                 310                 315                 320 

Arg Tyr Ile Gln Leu Glu Gly Val Thr Ser Ser Gln Asn Tyr Gln Asn 
                325                 330                 335     

Gln Ser Gly Asn Ile Ser Ser Tyr Gly Ser Asn Asn Ser Ser Thr Val 
            340                 345                 350         

Gly Trp Lys Lys Ile Asn Gly Ser Trp Tyr His Phe Lys Ser Asn Gly 
        355                 360                 365             

Ser Lys Ser Thr Gly Trp Leu Lys Asp Gly Ser Ser Trp Tyr Tyr Leu 
    370                 375                 380                 

Lys Leu Ser Gly Glu Met Gln Thr Gly Trp Leu Lys Glu Asn Gly Ser 
385                 390                 395                 400 

Trp Tyr Tyr Leu Gly Ser Ser Gly Ala Met Lys Thr Gly Trp Tyr Gln 
                405                 410                 415     

Val Ser Gly Glu Trp Tyr Tyr Ser Tyr Ser Ser Gly Ala Leu Ala Ile 
            420                 425                 430         

Asn Thr Thr Val Asp Gly Tyr Arg Val Asn Ser Asp Gly Glu Arg Val 
        435                 440                 445             


<210>   301
<211>   448
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   variant of SEQ ID NO: 300

<400>   301
Met Lys Ile Leu Pro Phe Ile Ala Arg Gly Thr Ser Tyr Tyr Leu Lys 
1               5                   10                  15      

Met Ser Val Lys Lys Leu Val Pro Phe Leu Val Val Gly Leu Met Leu 
            20                  25                  30          

Ala Ala Gly Asp Ser Val Tyr Ala Tyr Ser Arg Gly Asn Gly Ser Ile 
        35                  40                  45              

Ala Arg Gly Asp Asp Tyr Pro Ala Tyr Tyr Lys Asn Gly Ser Gln Glu 
    50                  55                  60                  

Ile Asp Gln Trp Arg Met Tyr Ser Arg Gln Cys Thr Ser Phe Val Ala 
65                  70                  75                  80  

Phe Arg Leu Ser Asn Val Asn Gly Phe Glu Ile Pro Ala Ala Tyr Gly 
                85                  90                  95      

Asn Ala Asn Glu Trp Gly His Arg Ala Arg Arg Glu Gly Tyr Arg Val 
            100                 105                 110         

Asp Asn Thr Pro Thr Ile Gly Ser Ile Thr Trp Ser Thr Ala Gly Thr 
        115                 120                 125             

Tyr Gly His Val Ala Trp Val Ser Asn Val Met Gly Asp Gln Ile Glu 
    130                 135                 140                 

Ile Glu Glu Tyr Asn Tyr Gly Tyr Thr Glu Ser Tyr Asn Lys Arg Val 
145                 150                 155                 160 

Ile Lys Ala Asn Thr Met Thr Gly Phe Ile His Phe Lys Asp Leu Asp 
                165                 170                 175     

Gly Gly Ser Val Gly Asn Ser Gln Ser Ser Thr Ser Thr Gly Gly Thr 
            180                 185                 190         

His Tyr Phe Lys Thr Lys Ser Ala Ile Lys Thr Glu Pro Leu Ala Ser 
        195                 200                 205             

Gly Thr Val Ile Asp Tyr Tyr Tyr Pro Gly Glu Lys Val His Tyr Asp 
    210                 215                 220                 

Gln Ile Leu Glu Lys Asp Gly Tyr Lys Trp Leu Ser Tyr Thr Ala Tyr 
225                 230                 235                 240 

Asn Gly Ser Tyr Arg Tyr Val Gln Leu Glu Ala Val Asn Lys Asn Pro 
                245                 250                 255     

Leu Gly Asn Ser Val Leu Ser Ser Thr Gly Gly Thr His Tyr Phe Lys 
            260                 265                 270         

Thr Lys Ser Ala Ile Lys Thr Glu Pro Leu Val Ser Ala Thr Val Ile 
        275                 280                 285             

Asp Tyr Tyr Tyr Pro Gly Glu Lys Val His Tyr Asp Gln Ile Leu Glu 
    290                 295                 300                 

Lys Asp Gly Tyr Lys Trp Leu Ser Tyr Thr Ala Tyr Asn Gly Ser Arg 
305                 310                 315                 320 

Arg Tyr Ile Gln Leu Glu Gly Val Thr Ser Ser Gln Asn Tyr Gln Asn 
                325                 330                 335     

Gln Ser Gly Asn Ile Ser Ser Tyr Gly Ser His Ser Ser Ser Thr Val 
            340                 345                 350         

Gly Trp Lys Lys Ile Asn Gly Ser Trp Tyr His Phe Lys Ser Asn Gly 
        355                 360                 365             

Ser Lys Ser Thr Gly Trp Leu Lys Asp Gly Ser Ser Trp Tyr Tyr Leu 
    370                 375                 380                 

Lys Leu Ser Gly Glu Met Gln Thr Gly Trp Leu Lys Glu Asn Gly Leu 
385                 390                 395                 400 

Trp Tyr Tyr Leu Gly Ser Ser Gly Ala Met Lys Thr Gly Trp Tyr Gln 
                405                 410                 415     

Val Ser Gly Lys Trp Tyr Tyr Ser Tyr Ser Ser Gly Ala Leu Ala Val 
            420                 425                 430         

Asn Thr Thr Val Asp Gly Tyr Arg Val Asn Ser Asp Gly Glu Arg Val 
        435                 440                 445             


<210>   302
<211>   42
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length CbpG

<400>   302
Met Leu Thr Asp Trp Gln Lys Val Asn Gly Asn Trp Tyr Tyr Leu Asn 
1               5                   10                  15      

Ser Asn Gly Ala Met Val Thr Gly Ser Gln Thr Ile Asp Gly Lys Val 
            20                  25                  30          

Tyr Asn Phe Ala Ser Ser Gly Glu Trp Ile 
        35                  40          

<210>   303
<211>   204
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length PvaA

<400>   303
Met Phe Lys Arg Ile Arg Arg Val Leu Val Leu Ala Val Phe Leu Phe 
1               5                   10                  15      

Ala Gly Tyr Lys Ala Tyr Arg Val His Gln Asp Val Lys Gln Val Met 
            20                  25                  30          

Thr Tyr Gln Pro Met Val Arg Glu Ile Leu Ser Glu Gln Asp Thr Pro 
        35                  40                  45              

Ala Asn Glu Glu Leu Val Leu Ala Met Ile Tyr Thr Glu Thr Lys Gly 
    50                  55                  60                  

Lys Glu Gly Asp Val Met Gln Ser Ser Glu Ser Ala Ser Gly Ser Thr 
65                  70                  75                  80  

Asn Thr Ile Asn Asp Asn Ala Ser Ser Ile Arg Gln Gly Ile Gln Thr 
                85                  90                  95      

Leu Thr Gly Asn Leu Tyr Leu Ala Gln Lys Lys Gly Val Asp Ile Trp 
            100                 105                 110         

Thr Ala Val Gln Ala Tyr Asn Phe Gly Pro Ala Tyr Ile Asp Phe Ile 
        115                 120                 125             

Ala Gln Asn Gly Lys Glu Asn Thr Leu Ala Leu Ala Lys Gln Tyr Ser 
    130                 135                 140                 

Arg Glu Thr Val Ala Pro Leu Leu Gly Asn Arg Thr Gly Lys Thr Tyr 
145                 150                 155                 160 

Ser Tyr Ile His Pro Ile Ser Ile Phe His Gly Ala Glu Leu Tyr Val 
                165                 170                 175     

Asn Gly Gly Asn Tyr Tyr Tyr Ser Arg Gln Val Arg Leu Asn Leu Tyr 
            180                 185                 190         

Ile Ile Lys Cys Phe Thr Leu Phe Ser Thr Ser Gly 
        195                 200                 

<210>   304
<211>   339
<212>   PRT
<213>   Streptococcus pneumoniae phage CP1

<220>
<223>   full length CPL1

<400>   304
Met Val Lys Lys Asn Asp Leu Phe Val Asp Val Ser Ser His Asn Gly 
1               5                   10                  15      

Tyr Asp Ile Thr Gly Ile Leu Glu Gln Met Gly Thr Thr Asn Thr Ile 
            20                  25                  30          

Ile Lys Ile Ser Glu Ser Thr Thr Tyr Leu Asn Pro Cys Leu Ser Ala 
        35                  40                  45              

Gln Val Glu Gln Ser Asn Pro Ile Gly Phe Tyr His Phe Ala Arg Phe 
    50                  55                  60                  

Gly Gly Asp Val Ala Glu Ala Glu Arg Glu Ala Gln Phe Phe Leu Asp 
65                  70                  75                  80  

Asn Val Pro Met Gln Val Lys Tyr Leu Val Leu Asp Tyr Glu Asp Asp 
                85                  90                  95      

Pro Ser Gly Asp Ala Gln Ala Asn Thr Asn Ala Cys Leu Arg Phe Met 
            100                 105                 110         

Gln Met Ile Ala Asp Ala Gly Tyr Lys Pro Ile Tyr Tyr Ser Tyr Lys 
        115                 120                 125             

Pro Phe Thr His Asp Asn Val Asp Tyr Gln Gln Ile Leu Ala Gln Phe 
    130                 135                 140                 

Pro Asn Ser Leu Trp Ile Ala Gly Tyr Gly Leu Asn Asp Gly Thr Ala 
145                 150                 155                 160 

Asn Phe Glu Tyr Phe Pro Ser Met Asp Gly Ile Arg Trp Trp Gln Tyr 
                165                 170                 175     

Ser Ser Asn Pro Phe Asp Lys Asn Ile Val Leu Leu Asp Asp Glu Glu 
            180                 185                 190         

Asp Asp Lys Pro Lys Thr Ala Gly Thr Trp Lys Gln Asp Ser Lys Gly 
        195                 200                 205             

Trp Trp Phe Arg Arg Asn Asn Gly Ser Phe Pro Tyr Asn Lys Trp Glu 
    210                 215                 220                 

Lys Ile Gly Gly Val Trp Tyr Tyr Phe Asp Ser Lys Gly Tyr Cys Leu 
225                 230                 235                 240 

Thr Ser Glu Trp Leu Lys Asp Asn Glu Lys Trp Tyr Tyr Leu Lys Asp 
                245                 250                 255     

Asn Gly Ala Met Ala Thr Gly Trp Val Leu Val Gly Ser Glu Trp Tyr 
            260                 265                 270         

Tyr Met Asp Asp Ser Gly Ala Met Val Thr Gly Trp Val Lys Tyr Lys 
        275                 280                 285             

Asn Asn Trp Tyr Tyr Met Thr Asn Glu Arg Gly Asn Met Val Ser Asn 
    290                 295                 300                 

Glu Phe Ile Lys Ser Gly Lys Gly Trp Tyr Phe Met Asn Thr Asn Gly 
305                 310                 315                 320 

Glu Leu Ala Asp Asn Pro Ser Phe Thr Lys Glu Pro Asp Gly Leu Ile 
                325                 330                 335     

Thr Val Ala 
            

<210>   305
<211>   279
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IC23

<400>   305
Met Ala Val Met Ala Tyr Pro Leu Val Ser Arg Leu Tyr Tyr Arg Val 
1               5                   10                  15      

Glu Ser Asn Gln Gln Ile Ala Asp Phe Asp Lys Glu Lys Ala Thr Leu 
            20                  25                  30          

Asp Glu Ala Asp Ile Asp Glu Arg Met Lys Leu Ala Gln Ala Phe Asn 
        35                  40                  45              

Asp Ser Leu Asn Asn Val Val Ser Gly Asp Pro Trp Ser Glu Glu Met 
    50                  55                  60                  

Lys Lys Lys Gly Arg Ala Glu Tyr Ala Arg Met Leu Glu Ile His Glu 
65                  70                  75                  80  

Arg Met Gly His Val Glu Ile Pro Val Ile Asp Val Asp Leu Pro Val 
                85                  90                  95      

Tyr Ala Gly Thr Ala Glu Glu Val Leu Gln Gln Gly Ala Gly His Leu 
            100                 105                 110         

Glu Gly Thr Ser Leu Pro Ile Gly Gly Asn Ser Thr His Ala Val Ile 
        115                 120                 125             

Thr Ala His Thr Gly Leu Pro Thr Ala Lys Met Phe Thr Asp Leu Thr 
    130                 135                 140                 

Lys Leu Lys Val Gly Asp Lys Phe Tyr Val His Asn Ile Lys Glu Val 
145                 150                 155                 160 

Met Ala Tyr Gln Val Asp Gln Val Lys Val Ile Glu Pro Thr Asn Phe 
                165                 170                 175     

Asp Asp Leu Leu Ile Val Pro Gly His Asp Tyr Val Thr Leu Leu Thr 
            180                 185                 190         

Cys Thr Pro Tyr Met Ile Asn Thr His Arg Leu Leu Val Arg Gly His 
        195                 200                 205             

Arg Ile Pro Tyr Val Ala Glu Val Glu Glu Glu Phe Ile Ala Ala Asn 
    210                 215                 220                 

Lys Leu Ser His Leu Tyr Arg Tyr Leu Phe Tyr Val Ala Val Gly Leu 
225                 230                 235                 240 

Ile Val Ile Leu Leu Trp Ile Ile Arg Arg Leu Arg Lys Lys Lys Lys 
                245                 250                 255     

Gln Pro Glu Lys Ala Leu Lys Ala Leu Lys Ala Ala Arg Lys Glu Val 
            260                 265                 270         

Lys Val Glu Asp Gly Gln Gln 
        275                 

<210>   306
<211>   612
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length Hic

<400>   306
Met Phe Ala Phe Lys Lys Arg Arg Lys Val His Tyr Ser Ile Arg Lys 
1               5                   10                  15      

Phe Ser Ile Gly Val Ala Ser Val Ala Val Ala Ser Leu Phe Met Gly 
            20                  25                  30          

Ser Val Val His Ala Thr Glu Lys Glu Val Thr Thr Gln Val Ala Thr 
        35                  40                  45              

Ser Ser Asn Lys Ala Asn Lys Ser Gln Thr Glu His Met Lys Ala Ala 
    50                  55                  60                  

Lys Gln Val Asp Glu Tyr Ile Glu Lys Met Leu Ser Glu Ile Gln Leu 
65                  70                  75                  80  

Asp Arg Arg Lys His Thr Gln Asn Val Gly Leu Leu Thr Lys Leu Gly 
                85                  90                  95      

Ala Ile Lys Thr Glu Tyr Leu Arg Gly Leu Ser Val Ser Lys Glu Lys 
            100                 105                 110         

Ser Thr Ala Glu Leu Pro Ser Glu Ile Lys Glu Lys Leu Thr Ala Ala 
        115                 120                 125             

Phe Glu Gln Phe Lys Lys Asp Thr Leu Lys Ser Gly Lys Lys Val Ala 
    130                 135                 140                 

Glu Ala Gln Lys Lys Ala Lys Asp Gln Lys Glu Ala Lys Gln Glu Ile 
145                 150                 155                 160 

Glu Ala Leu Ile Val Lys His Lys Gly Arg Glu Ile Asp Leu Asp Arg 
                165                 170                 175     

Lys Lys Ala Lys Ala Ala Val Thr Glu His Leu Lys Lys Leu Leu Asn 
            180                 185                 190         

Asp Ile Glu Lys Asn Leu Lys Lys Glu Gln His Thr His Thr Val Glu 
        195                 200                 205             

Leu Ile Lys Asn Leu Lys Asp Ile Glu Lys Thr Tyr Leu His Lys Leu 
    210                 215                 220                 

Asp Glu Ser Thr Gln Lys Ala Gln Leu Gln Lys Leu Ile Ala Glu Ser 
225                 230                 235                 240 

Gln Ser Lys Leu Asp Glu Ala Phe Ser Lys Phe Lys Asn Gly Leu Ser 
                245                 250                 255     

Ser Ser Ser Asn Ser Gly Ser Ser Thr Lys Pro Glu Thr Pro Gln Pro 
            260                 265                 270         

Glu Thr Pro Lys Pro Glu Val Lys Pro Glu Leu Glu Thr Pro Lys Pro 
        275                 280                 285             

Glu Val Lys Pro Glu Pro Glu Thr Pro Lys Pro Glu Val Lys Pro Glu 
    290                 295                 300                 

Pro Glu Thr Pro Lys Pro Glu Val Lys Pro Glu Leu Glu Thr Pro Lys 
305                 310                 315                 320 

Pro Glu Val Lys Pro Glu Pro Glu Thr Pro Lys Pro Glu Val Lys Pro 
                325                 330                 335     

Glu Pro Glu Thr Pro Lys Pro Glu Val Lys Pro Glu Pro Glu Thr Pro 
            340                 345                 350         

Lys Pro Glu Val Lys Pro Glu Leu Glu Thr Pro Lys Pro Glu Val Lys 
        355                 360                 365             

Pro Glu Leu Glu Thr Pro Lys Pro Glu Val Lys Pro Glu Pro Glu Thr 
    370                 375                 380                 

Pro Lys Pro Glu Val Lys Pro Glu Leu Glu Thr Pro Lys Pro Glu Val 
385                 390                 395                 400 

Lys Pro Glu Pro Glu Thr Pro Lys Pro Glu Val Lys Pro Glu Leu Glu 
                405                 410                 415     

Thr Pro Lys Pro Glu Val Lys Pro Glu Pro Glu Thr Pro Lys Pro Glu 
            420                 425                 430         

Val Lys Pro Glu Leu Glu Thr Pro Lys Pro Glu Val Lys Pro Glu Pro 
        435                 440                 445             

Glu Thr Pro Lys Pro Glu Val Lys Pro Glu Pro Glu Thr Pro Lys Pro 
    450                 455                 460                 

Glu Val Lys Pro Glu Pro Glu Thr Pro Lys Pro Glu Val Lys Pro Glu 
465                 470                 475                 480 

Leu Glu Thr Pro Lys Gln Lys Val Lys Pro Glu Pro Glu Thr Pro Lys 
                485                 490                 495     

Pro Glu Val Lys Pro Glu Pro Glu Thr Pro Lys Pro Glu Val Lys Pro 
            500                 505                 510         

Glu Leu Glu Thr Pro Lys Pro Glu Val Lys Pro Glu Leu Glu Ile Pro 
        515                 520                 525             

Lys Pro Glu Val Lys Pro Asp Asn Ser Lys Pro Gln Ala Asp Asp Lys 
    530                 535                 540                 

Lys Pro Ser Thr Pro Asn Asn Leu Ser Lys Asp Lys Gln Ser Ser Asn 
545                 550                 555                 560 

Gln Ala Ser Thr Asn Glu Asn Lys Lys Gln Gly Pro Ala Thr Asn Lys 
                565                 570                 575     

Pro Lys Lys Ser Leu Pro Ser Thr Gly Ser Ile Ser Asn Leu Ala Leu 
            580                 585                 590         

Glu Ile Ala Gly Leu Leu Thr Leu Ala Gly Ala Thr Ile Leu Ala Lys 
        595                 600                 605             

Lys Arg Met Lys 
    610         

<210>   307
<211>   619
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length PspA

<400>   307
Met Asn Lys Lys Lys Met Ile Leu Thr Ser Leu Ala Ser Val Ala Ile 
1               5                   10                  15      

Leu Gly Ala Gly Phe Val Ala Ser Gln Pro Thr Val Val Arg Ala Glu 
            20                  25                  30          

Glu Ser Pro Val Ala Ser Gln Ser Lys Ala Glu Lys Asp Tyr Asp Ala 
        35                  40                  45              

Ala Lys Lys Asp Ala Lys Asn Ala Lys Lys Ala Val Glu Asp Ala Gln 
    50                  55                  60                  

Lys Ala Leu Asp Asp Ala Lys Ala Ala Gln Lys Lys Tyr Asp Glu Asp 
65                  70                  75                  80  

Gln Lys Lys Thr Glu Glu Lys Ala Ala Leu Glu Lys Ala Ala Ser Glu 
                85                  90                  95      

Glu Met Asp Lys Ala Val Ala Ala Val Gln Gln Ala Tyr Leu Ala Tyr 
            100                 105                 110         

Gln Gln Ala Thr Asp Lys Ala Ala Lys Asp Ala Ala Asp Lys Met Ile 
        115                 120                 125             

Asp Glu Ala Lys Lys Arg Glu Glu Glu Ala Lys Thr Lys Phe Asn Thr 
    130                 135                 140                 

Val Arg Ala Met Val Val Pro Glu Pro Glu Gln Leu Ala Glu Thr Lys 
145                 150                 155                 160 

Lys Lys Ser Glu Glu Ala Lys Gln Lys Ala Pro Glu Leu Thr Lys Lys 
                165                 170                 175     

Leu Glu Glu Ala Lys Ala Lys Leu Glu Glu Ala Glu Lys Lys Ala Thr 
            180                 185                 190         

Glu Ala Lys Gln Lys Val Asp Ala Glu Glu Val Ala Pro Gln Ala Lys 
        195                 200                 205             

Ile Ala Glu Leu Glu Asn Gln Val His Arg Leu Glu Gln Glu Leu Lys 
    210                 215                 220                 

Glu Ile Asp Glu Ser Glu Ser Glu Asp Tyr Ala Lys Glu Gly Phe Arg 
225                 230                 235                 240 

Ala Pro Leu Gln Ser Lys Leu Asp Ala Lys Lys Ala Lys Leu Ser Lys 
                245                 250                 255     

Leu Glu Glu Leu Ser Asp Lys Ile Asp Glu Leu Asp Ala Glu Ile Ala 
            260                 265                 270         

Lys Leu Glu Asp Gln Leu Lys Ala Ala Glu Glu Asn Asn Asn Val Glu 
        275                 280                 285             

Asp Tyr Phe Lys Glu Gly Leu Glu Lys Thr Ile Ala Ala Lys Lys Ala 
    290                 295                 300                 

Glu Leu Glu Lys Thr Glu Ala Asp Leu Lys Lys Ala Val Asn Glu Pro 
305                 310                 315                 320 

Glu Lys Pro Ala Pro Ala Pro Glu Thr Pro Ala Pro Glu Ala Pro Ala 
                325                 330                 335     

Glu Gln Pro Lys Pro Ala Pro Ala Pro Gln Pro Ala Pro Ala Pro Lys 
            340                 345                 350         

Pro Glu Lys Pro Ala Glu Gln Pro Lys Pro Glu Lys Thr Asp Asp Gln 
        355                 360                 365             

Gln Ala Glu Glu Asp Tyr Ala Arg Arg Ser Glu Glu Glu Tyr Asn Arg 
    370                 375                 380                 

Leu Thr Gln Gln Gln Pro Pro Lys Ala Glu Lys Pro Ala Pro Ala Pro 
385                 390                 395                 400 

Lys Thr Gly Trp Lys Gln Glu Asn Gly Met Trp Tyr Phe Tyr Asn Thr 
                405                 410                 415     

Asp Gly Ser Met Ala Thr Gly Trp Leu Gln Asn Asn Gly Ser Trp Tyr 
            420                 425                 430         

Tyr Leu Asn Ser Asn Gly Ala Met Ala Thr Gly Trp Leu Gln Tyr Asn 
        435                 440                 445             

Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Ala Met Ala Thr Gly Trp 
    450                 455                 460                 

Ala Lys Val Asn Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Ala Met 
465                 470                 475                 480 

Ala Thr Gly Trp Leu Gln Tyr Asn Gly Ser Trp Tyr Tyr Leu Asn Ala 
                485                 490                 495     

Asn Gly Ala Met Ala Thr Gly Trp Ala Lys Val Asn Gly Ser Trp Tyr 
            500                 505                 510         

Tyr Leu Asn Ala Asn Gly Ala Met Ala Thr Gly Trp Leu Gln Tyr Asn 
        515                 520                 525             

Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Ala Met Ala Thr Gly Trp 
    530                 535                 540                 

Ala Lys Val Asn Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Ala Met 
545                 550                 555                 560 

Ala Thr Gly Trp Val Lys Asp Gly Asp Thr Trp Tyr Tyr Leu Glu Ala 
                565                 570                 575     

Ser Gly Ala Met Lys Ala Ser Gln Trp Phe Lys Val Ser Asp Lys Trp 
            580                 585                 590         

Tyr Tyr Val Asn Gly Leu Gly Ala Leu Ala Val Asn Thr Thr Val Asp 
        595                 600                 605             

Gly Tyr Lys Val Asn Ala Asn Gly Glu Trp Val 
    610                 615                 

<210>   308
<211>   309
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length PsaA

<400>   308
Met Lys Lys Leu Gly Thr Leu Leu Val Leu Phe Leu Ser Ala Ile Ile 
1               5                   10                  15      

Leu Val Ala Cys Ala Ser Gly Lys Lys Asp Thr Thr Ser Gly Gln Lys 
            20                  25                  30          

Leu Lys Val Val Ala Thr Asn Ser Ile Ile Ala Asp Ile Thr Lys Asn 
        35                  40                  45              

Ile Ala Gly Asp Lys Ile Asp Leu His Ser Ile Val Pro Ile Gly Gln 
    50                  55                  60                  

Asp Pro His Glu Tyr Glu Pro Leu Pro Glu Asp Val Lys Lys Thr Ser 
65                  70                  75                  80  

Glu Ala Asp Leu Ile Phe Tyr Asn Gly Ile Asn Leu Glu Thr Gly Gly 
                85                  90                  95      

Asn Ala Trp Phe Thr Lys Leu Val Glu Asn Ala Lys Lys Thr Glu Asn 
            100                 105                 110         

Lys Asp Tyr Phe Ala Val Ser Asp Gly Val Asp Val Ile Tyr Leu Glu 
        115                 120                 125             

Gly Gln Asn Glu Lys Gly Lys Glu Asp Pro His Ala Trp Leu Asn Leu 
    130                 135                 140                 

Glu Asn Gly Ile Ile Phe Ala Lys Asn Ile Ala Lys Gln Leu Ser Ala 
145                 150                 155                 160 

Lys Asp Pro Asn Asn Lys Glu Phe Tyr Glu Lys Asn Leu Lys Glu Tyr 
                165                 170                 175     

Thr Asp Lys Leu Asp Lys Leu Asp Lys Glu Ser Lys Asp Lys Phe Asn 
            180                 185                 190         

Lys Ile Pro Ala Glu Lys Lys Leu Ile Val Thr Ser Glu Gly Ala Phe 
        195                 200                 205             

Lys Tyr Phe Ser Lys Ala Tyr Gly Val Pro Ser Ala Tyr Ile Trp Glu 
    210                 215                 220                 

Ile Asn Thr Glu Glu Glu Gly Thr Pro Glu Gln Ile Lys Thr Leu Val 
225                 230                 235                 240 

Glu Lys Leu Arg Gln Thr Lys Val Pro Ser Leu Phe Val Glu Ser Ser 
                245                 250                 255     

Val Asp Asp Arg Pro Met Lys Thr Val Ser Gln Asp Thr Asn Ile Pro 
            260                 265                 270         

Ile Tyr Ala Gln Ile Phe Thr Asp Ser Ile Ala Glu Gln Gly Lys Glu 
        275                 280                 285             

Gly Asp Ser Tyr Tyr Ser Met Met Lys Tyr Asn Leu Asp Lys Ile Ala 
    290                 295                 300                 

Glu Gly Leu Ala Lys 
305                 

<210>   309
<211>   2144
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length PrtA

<400>   309
Met Lys Lys Ser Thr Val Leu Ser Leu Thr Thr Ala Ala Val Ile Leu 
1               5                   10                  15      

Ala Ala Tyr Ala Pro Asn Glu Val Val Leu Ala Asp Thr Ser Ser Ser 
            20                  25                  30          

Glu Asp Ala Leu Ser Ile Ser Asp Lys Glu Lys Val Val Val Asp Lys 
        35                  40                  45              

Glu Thr Glu Asn Lys Glu Lys His Lys Asp Ile His Asn Ala Ile Glu 
    50                  55                  60                  

Thr Ser Lys Asp Thr Glu Glu Lys Lys Thr Thr Ile Ile Glu Glu Lys 
65                  70                  75                  80  

Glu Val Val Ser Lys Asn Pro Val Ile Asp Thr Lys Thr Ser Asn Glu 
                85                  90                  95      

Glu Ala Lys Ile Lys Glu Glu Asn Ser Asn Gln Ser Gln Gly Asp His 
            100                 105                 110         

Thr Asp Ser Phe Val Asn Lys Asn Thr Glu Asn Pro Lys Lys Glu Asp 
        115                 120                 125             

Lys Val Val Tyr Ile Ala Glu Phe Lys Asp Lys Glu Ser Gly Glu Lys 
    130                 135                 140                 

Ala Ile Lys Gly Leu Ser Asn Leu Lys Asn Thr Lys Val Leu Tyr Thr 
145                 150                 155                 160 

Tyr Asp Arg Ile Phe Asn Gly Ser Ala Ile Glu Thr Thr Pro Asp Asn 
                165                 170                 175     

Leu Asp Lys Ile Lys Gln Ile Glu Gly Ile Ser Ser Ile Glu Arg Ala 
            180                 185                 190         

Gln Lys Val Gln Pro Met Met Asn His Ala Arg Lys Glu Ile Gly Val 
        195                 200                 205             

Glu Glu Ala Ile Asp Tyr Leu Lys Ser Ile Asn Ala Pro Phe Gly Lys 
    210                 215                 220                 

Asn Phe Asp Gly Arg Gly Met Val Ile Ser Asn Ile Asp Thr Gly Thr 
225                 230                 235                 240 

Asp Tyr Arg His Lys Ala Met Arg Ile Asp Asp Asp Ala Lys Ala Ser 
                245                 250                 255     

Met Arg Phe Lys Lys Glu Asp Leu Lys Gly Thr Asp Lys Asn Tyr Trp 
            260                 265                 270         

Leu Ser Asp Lys Ile Pro His Ala Phe Asn Tyr Tyr Asn Gly Gly Lys 
        275                 280                 285             

Ile Thr Val Glu Lys Tyr Asp Asp Gly Arg Asp Tyr Phe Asp Pro His 
    290                 295                 300                 

Gly Met His Ile Ala Gly Ile Leu Ala Gly Asn Asp Thr Glu Gln Asp 
305                 310                 315                 320 

Ile Lys Asn Phe Asn Gly Ile Asp Gly Ile Ala Pro Asn Ala Gln Ile 
                325                 330                 335     

Phe Ser Tyr Lys Met Tyr Ser Asp Ala Gly Ser Gly Phe Ala Gly Asp 
            340                 345                 350         

Glu Thr Met Phe His Ala Ile Glu Asp Ser Ile Lys His Asn Val Asp 
        355                 360                 365             

Val Val Ser Val Ser Ser Gly Phe Thr Gly Thr Gly Leu Val Gly Glu 
    370                 375                 380                 

Lys Tyr Trp Gln Ala Ile Arg Ala Leu Arg Lys Ala Gly Ile Pro Met 
385                 390                 395                 400 

Val Val Ala Thr Gly Asn Tyr Ala Thr Ser Ala Ser Ser Ser Ser Trp 
                405                 410                 415     

Asp Leu Val Ala Asn Asn His Leu Lys Met Thr Asp Thr Gly Asn Val 
            420                 425                 430         

Thr Arg Thr Ala Ala His Glu Asp Ala Ile Ala Val Ala Ser Ala Lys 
        435                 440                 445             

Asn Gln Thr Val Glu Phe Asp Lys Val Asn Ile Gly Gly Glu Ser Phe 
    450                 455                 460                 

Lys Tyr Arg Asn Ile Gly Ala Phe Phe Asp Lys Asn Lys Ile Thr Thr 
465                 470                 475                 480 

Asn Glu Asp Gly Thr Lys Ala Pro Ser Lys Leu Lys Phe Val Tyr Ile 
                485                 490                 495     

Gly Lys Gly Gln Asp Gln Asp Leu Ile Gly Leu Asp Leu Arg Gly Lys 
            500                 505                 510         

Ile Ala Val Met Asp Arg Ile Tyr Thr Lys Asp Leu Lys Asn Ala Phe 
        515                 520                 525             

Lys Lys Ala Met Asp Lys Gly Ala Arg Ala Ile Met Val Val Asn Thr 
    530                 535                 540                 

Val Asn Tyr Tyr Asn Arg Asp Asn Trp Thr Glu Leu Pro Ala Met Gly 
545                 550                 555                 560 

Tyr Glu Ala Asp Glu Gly Thr Lys Ser Gln Val Phe Ser Ile Ser Gly 
                565                 570                 575     

Asp Asp Gly Val Lys Leu Trp Asn Met Ile Asn Pro Asp Lys Lys Thr 
            580                 585                 590         

Glu Val Lys Arg Asn Asn Lys Glu Asp Phe Lys Asp Lys Leu Glu Gln 
        595                 600                 605             

Tyr Tyr Pro Ile Asp Met Glu Ser Phe Asn Ser Asn Lys Pro Asn Val 
    610                 615                 620                 

Gly Asp Glu Lys Glu Ile Asp Phe Lys Phe Ala Pro Asp Thr Asp Lys 
625                 630                 635                 640 

Glu Leu Tyr Lys Glu Asp Ile Ile Val Pro Ala Gly Ser Thr Ser Trp 
                645                 650                 655     

Gly Pro Arg Ile Asp Leu Leu Leu Lys Pro Asp Val Ser Ala Pro Gly 
            660                 665                 670         

Lys Asn Ile Lys Ser Thr Leu Asn Val Ile Asn Gly Lys Ser Thr Tyr 
        675                 680                 685             

Gly Tyr Met Ser Gly Thr Ser Met Ala Thr Pro Ile Val Ala Ala Ser 
    690                 695                 700                 

Thr Val Leu Ile Arg Pro Lys Leu Lys Glu Met Leu Glu Arg Pro Val 
705                 710                 715                 720 

Leu Lys Asn Leu Lys Gly Asp Asp Lys Ile Asp Leu Thr Ser Leu Thr 
                725                 730                 735     

Lys Ile Ala Leu Gln Asn Thr Ala Arg Pro Met Met Asp Ala Thr Ser 
            740                 745                 750         

Trp Lys Glu Lys Ser Gln Tyr Phe Ala Ser Pro Arg Gln Gln Gly Ala 
        755                 760                 765             

Gly Leu Ile Asn Val Ala Asn Ala Leu Arg Asn Glu Val Val Ala Thr 
    770                 775                 780                 

Phe Lys Asn Thr Asp Ser Lys Gly Leu Val Asn Ser Tyr Gly Ser Ile 
785                 790                 795                 800 

Ser Leu Lys Glu Ile Lys Gly Asp Lys Lys Tyr Phe Thr Ile Lys Leu 
                805                 810                 815     

His Asn Thr Ser Asn Arg Pro Leu Thr Phe Lys Val Ser Ala Ser Ala 
            820                 825                 830         

Ile Thr Thr Asp Ser Leu Thr Asp Arg Leu Lys Leu Asp Glu Thr Tyr 
        835                 840                 845             

Lys Asp Glu Lys Ser Pro Asp Gly Lys Gln Ile Val Pro Glu Ile His 
    850                 855                 860                 

Pro Glu Lys Val Lys Gly Ala Asn Ile Thr Phe Glu His Gly Thr Phe 
865                 870                 875                 880 

Thr Ile Gly Ala Asn Ser Ser Phe Asp Leu Asn Ala Val Ile Asn Val 
                885                 890                 895     

Gly Glu Ala Lys Asn Lys Asn Lys Phe Val Glu Ser Phe Ile His Phe 
            900                 905                 910         

Glu Ser Val Glu Glu Met Glu Ala Leu Asn Ser Asn Gly Lys Lys Ile 
        915                 920                 925             

Asn Phe Gln Pro Ser Leu Ser Met Pro Leu Met Gly Phe Ala Gly Asn 
    930                 935                 940                 

Trp Asn His Glu Pro Ile Leu Asp Lys Trp Ala Trp Glu Glu Gly Ser 
945                 950                 955                 960 

Arg Ser Lys Thr Leu Gly Gly Tyr Asp Asp Asp Gly Lys Pro Lys Ile 
                965                 970                 975     

Pro Gly Thr Leu Asn Lys Gly Ile Gly Gly Glu His Gly Ile Asp Lys 
            980                 985                 990         

Phe Asn Pro Ala Gly Val Ile Gln Asn Arg Lys Asp Lys Asn Thr Thr 
        995                 1000                1005            

Ser Leu Asp Gln Asn Pro Glu Leu Phe Ala Phe Asn Asn Gln Gly Ile 
    1010                1015                1020                

Asn Ala Pro Ser Ser Ser Gly Ser Lys Ile Ala Asn Ile Tyr Pro Leu 
1025                1030                1035                1040

Asp Ser Asn Gly Asn Pro Gln Asp Ala Gln Leu Glu Arg Gly Leu Thr 
                1045                1050                1055    

Pro Ser Pro Leu Val Leu Arg Ser Ala Glu Glu Gly Leu Ile Ser Ile 
            1060                1065                1070        

Val Asn Thr Asn Lys Glu Gly Glu Asn Gln Arg Asp Leu Lys Val Ile 
        1075                1080                1085            

Ser Arg Glu His Phe Ile Arg Gly Ile Leu Asn Ser Lys Ser Asn Asp 
    1090                1095                1100                

Ala Lys Gly Ile Lys Ser Ser Lys Leu Lys Val Trp Gly Asp Leu Lys 
1105                1110                1115                1120

Trp Asp Gly Leu Ile Tyr Asn Pro Arg Gly Arg Glu Glu Asn Ala Pro 
                1125                1130                1135    

Glu Ser Lys Asp Asn Gln Asp Pro Ala Thr Lys Ile Arg Gly Gln Phe 
            1140                1145                1150        

Glu Pro Ile Ala Glu Gly Gln Tyr Phe Tyr Lys Phe Lys Tyr Arg Leu 
        1155                1160                1165            

Thr Lys Asp Tyr Pro Trp Gln Val Ser Tyr Ile Pro Val Lys Ile Asp 
    1170                1175                1180                

Asn Thr Ala Pro Lys Ile Val Ser Val Asp Phe Ser Asn Pro Glu Lys 
1185                1190                1195                1200

Ile Lys Leu Ile Thr Lys Asp Thr Tyr His Lys Val Lys Asp Gln Tyr 
                1205                1210                1215    

Lys Asn Glu Thr Leu Phe Ala Arg Asp Gln Lys Glu His Pro Glu Lys 
            1220                1225                1230        

Phe Asp Glu Ile Ala Asn Glu Val Trp Tyr Ala Gly Ala Ala Leu Val 
        1235                1240                1245            

Asn Glu Asp Gly Glu Val Glu Lys Asn Leu Glu Val Thr Tyr Ala Gly 
    1250                1255                1260                

Glu Gly Gln Gly Arg Asn Arg Lys Leu Asp Lys Asp Gly Asn Thr Ile 
1265                1270                1275                1280

Tyr Glu Ile Lys Gly Ala Gly Asp Leu Arg Gly Lys Ile Ile Glu Val 
                1285                1290                1295    

Ile Ala Leu Asp Gly Ser Ser Asn Phe Thr Lys Ile His Arg Ile Lys 
            1300                1305                1310        

Phe Ala Asp Gln Ala Asp Glu Lys Gly Met Ile Ser Tyr Tyr Leu Val 
        1315                1320                1325            

Asp Pro Asp Lys Asp Ala Ser Lys Tyr Glu Lys Leu Gly Glu Ile Ser 
    1330                1335                1340                

Glu Asp Lys Leu Lys Asn Ala Lys Ser Pro Glu Glu Asn Thr Asn Asn 
1345                1350                1355                1360

Asn Gln Ala Lys Asp Glu Asp Ser Lys Pro Asp Glu Lys Ser Ser Val 
                1365                1370                1375    

Glu Gly Glu Ala Ser Leu Glu Ile Asn Lys Thr Ile Ser Thr Ile Arg 
            1380                1385                1390        

Glu Phe Glu Asn Lys Asp Leu Lys Lys Leu Ile Lys Lys Lys Phe Arg 
        1395                1400                1405            

Glu Val Asn Asp Phe Thr Ser Glu Thr Gly Lys Arg Ile Glu Glu Tyr 
    1410                1415                1420                

Asp Tyr Lys Tyr Asp Asp Lys Gly Asn Ile Ile Ala Tyr Asp Asp Gly 
1425                1430                1435                1440

Ser Ala Leu Gln Tyr Glu Thr Glu Lys Phe Asp Glu Ile Lys Ser Lys 
                1445                1450                1455    

Ile Tyr Gly Val Leu Ser Pro Ser Lys Asp Gly His Phe Glu Ile Leu 
            1460                1465                1470        

Gly Lys Ile Ser Asn Val Ser Lys Asn Ala Lys Val Tyr Tyr Gly Asn 
        1475                1480                1485            

Ser Tyr Lys Ser Ile Glu Ile Lys Ala Thr Lys Tyr Asp Ser His Ser 
    1490                1495                1500                

Lys Thr Met Ile Phe Asp Leu Tyr Ala Asn Ile Asn Asp Ile Val Asp 
1505                1510                1515                1520

Gly Leu Ala Phe Ala Gly Asp Met Arg Leu Phe Val Lys Asp Asp Asn 
                1525                1530                1535    

Gln Ile Lys Ala Glu Thr Lys Ile Arg Met Pro Glu Lys Asn Lys Glu 
            1540                1545                1550        

Thr Lys Ala Glu Tyr Pro Tyr Val Ser Ser Tyr Gly Asn Val Ile Glu 
        1555                1560                1565            

Leu Gly Glu Gly Asp Leu Ser Lys Asn Lys Pro Asp Asn Leu Thr Lys 
    1570                1575                1580                

Met Glu Ser Gly Lys Ile Tyr Ser Asp Ser Glu Lys Gln Gln Tyr Leu 
1585                1590                1595                1600

Leu Lys Asp Asn Ile Ile Leu Arg Lys Gly Tyr Ala Leu Lys Val Thr 
                1605                1610                1615    

Thr Tyr Asn Pro Gly Lys Thr Asp Met Leu Glu Gly Asn Gly Val Tyr 
            1620                1625                1630        

Ser Lys Glu Asp Ile Ala Lys Ile Gln Lys Ala Asn Pro Asn Leu Arg 
        1635                1640                1645            

Val Leu Ser Glu Thr Thr Ile Tyr Ala Asp Ser Arg Asn Val Glu Asp 
    1650                1655                1660                

Gly Arg Ser Thr Gln Ala Val Leu Met Ser Ala Leu Asp Gly Phe Asn 
1665                1670                1675                1680

Ile Ile Arg Tyr Gln Val Phe Thr Phe Lys Met Asn Asp Lys Gly Glu 
                1685                1690                1695    

Ala Ile Asp Lys Asp Gly Asn Leu Val Thr Asp Ser Ser Lys Leu Val 
            1700                1705                1710        

Leu Phe Gly Lys Asp Asp Lys Glu Tyr Thr Gly Glu Asp Lys Ser Asn 
        1715                1720                1725            

Val Glu Ala Ile Lys Glu Asp Gly Ser Met Leu Phe Ile Asp Thr Lys 
    1730                1735                1740                

Pro Val Asn Leu Ser Met Asp Lys Asn Tyr Phe Asn Pro Ser Lys Ser 
1745                1750                1755                1760

Asn Lys Ile Tyr Val Arg Asn Pro Glu Phe Tyr Leu Arg Gly Lys Ile 
                1765                1770                1775    

Ser Asp Lys Gly Gly Phe Asn Trp Glu Leu Arg Val Asn Glu Ser Val 
            1780                1785                1790        

Val Asp Asn Tyr Leu Ile Tyr Gly Asp Leu His Ile Asp Asn Thr Arg 
        1795                1800                1805            

Asp Phe Asn Ile Lys Leu Asn Val Lys Asp Gly Asp Ile Met Asp Trp 
    1810                1815                1820                

Gly Met Lys Asp Tyr Lys Ala Asn Gly Phe Pro Asp Lys Val Thr Asp 
1825                1830                1835                1840

Met Asp Gly Asn Val Tyr Leu Gln Thr Gly Tyr Ser Asp Leu Asn Ala 
                1845                1850                1855    

Lys Ala Val Gly Val His Tyr Gln Phe Leu Tyr Asp Asn Val Lys Pro 
            1860                1865                1870        

Glu Val Asn Ile Asp Pro Lys Gly Asn Thr Ser Ile Glu Tyr Ala Asp 
        1875                1880                1885            

Gly Lys Ser Val Val Phe Asn Ile Asn Asp Lys Arg Asn Asn Gly Phe 
    1890                1895                1900                

Asp Gly Glu Ile Gln Glu Gln His Ile Tyr Val Asn Gly Lys Glu Tyr 
1905                1910                1915                1920

Thr Ser Phe Asp Asp Ile Lys Gln Ile Thr Asp Lys Thr Leu Asn Ile 
                1925                1930                1935    

Lys Ile Val Val Lys Asp Phe Ala Arg Asn Thr Thr Val Lys Glu Phe 
            1940                1945                1950        

Ile Leu Asn Lys Asp Thr Gly Glu Val Ser Glu Leu Lys Pro His Arg 
        1955                1960                1965            

Val Thr Val Thr Ile Gln Asn Gly Lys Glu Met Ser Ser Thr Ile Val 
    1970                1975                1980                

Ser Glu Glu Asp Phe Ile Leu Pro Val Tyr Lys Gly Glu Leu Glu Lys 
1985                1990                1995                2000

Gly Tyr Gln Phe Asp Gly Trp Glu Ile Ser Gly Phe Glu Gly Lys Lys 
                2005                2010                2015    

Asp Ala Gly Tyr Val Ile Asn Leu Ser Lys Asp Thr Phe Ile Lys Pro 
            2020                2025                2030        

Val Phe Lys Lys Ile Glu Glu Lys Lys Glu Glu Glu Asn Lys Pro Thr 
        2035                2040                2045            

Phe Asp Val Ser Lys Lys Lys Asp Asn Pro Gln Val Asn His Ser Gln 
    2050                2055                2060                

Leu Asn Glu Ser His Arg Lys Glu Asp Leu Gln Arg Glu Asp His Ser 
2065                2070                2075                2080

Gln Lys Ser Asp Ser Thr Lys Asp Val Thr Ala Thr Val Leu Asp Lys 
                2085                2090                2095    

Asn Asn Ile Ser Ser Lys Ser Thr Thr Asn Asn Pro Asn Lys Leu Pro 
            2100                2105                2110        

Lys Thr Gly Thr Ala Ser Gly Ala Gln Thr Leu Leu Ala Ala Gly Ile 
        2115                2120                2125            

Met Phe Ile Val Gly Ile Phe Leu Gly Leu Lys Lys Lys Asn Gln Asp 
    2130                2135                2140                


<210>   310
<211>   324
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length Sp133

<400>   310
Met Arg Lys Lys Leu Phe Leu Thr Ser Ala Ala Ile Leu Trp Ala Val 
1               5                   10                  15      

Thr Ala Met Asn Ser Val His Ala Ala Thr Asp Val Gln Lys Val Ile 
            20                  25                  30          

Asp Glu Thr Tyr Val Gln Pro Glu Tyr Val Leu Gly Ser Ser Leu Ser 
        35                  40                  45              

Glu Asp Gln Lys Asn Gln Thr Leu Lys Lys Leu Gly Tyr Asn Ala Ser 
    50                  55                  60                  

Thr Asp Thr Lys Glu Leu Lys Thr Met Thr Pro Asp Val Tyr Ser Lys 
65                  70                  75                  80  

Ile Met Asn Val Ala Asn Asp Ser Ser Leu Gln Leu Tyr Ser Ser Ala 
                85                  90                  95      

Lys Ile Gln Lys Leu Gly Asp Lys Ser Pro Leu Glu Val Lys Ile Glu 
            100                 105                 110         

Thr Pro Glu Asn Ile Thr Lys Val Thr Gln Asp Met Tyr Arg Asn Ala 
        115                 120                 125             

Ala Val Thr Leu Gly Val Glu His Ala Lys Ile Thr Val Ala Ala Pro 
    130                 135                 140                 

Ile Pro Val Thr Gly Glu Ser Ala Leu Ala Gly Ile Tyr Tyr Ser Leu 
145                 150                 155                 160 

Glu Ala Asn Gly Ala Lys Val Pro Gln Ala Asn Lys Asp Leu Ala Gln 
                165                 170                 175     

Glu Glu Leu Lys Ala Leu Ser Asp Ile Asn Ala Glu Asn Lys Asp Lys 
            180                 185                 190         

Ser Gly Tyr Asp Ala Asn Lys Leu Asn Val Ala Leu Ala Asp Ile Lys 
        195                 200                 205             

Ser Gly Leu Ala Lys Ala Lys Glu Ser Lys Gly Asn Leu Thr Glu Glu 
    210                 215                 220                 

Asp Ile Arg Lys Ile Val Glu Asp Thr Leu Lys Asn Tyr Lys Leu Asp 
225                 230                 235                 240 

Gln Val Ile Thr Gly Asn Gln Ile Asn Ile Ile Ile Asn Phe Ala Leu 
                245                 250                 255     

Asn Leu Ser Lys Ser Asp Ile Leu Ser Asn Ala Asp Phe Thr Lys Thr 
            260                 265                 270         

Leu Asn Asp Leu Lys Gln Ser Ile Val Ser Gln Ala Gly Asp Ser Phe 
        275                 280                 285             

Lys Asn Ile Asn Leu Asn Phe Asp Ser Asp Lys Ala Leu Glu Asp Gly 
    290                 295                 300                 

Gly Asn Phe Leu Ser Ser Leu Trp Gln Ala Leu Val Asn Phe Phe Lys 
305                 310                 315                 320 

Ser Phe Gly Ser 
                

<210>   311
<211>   339
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length PiaA

<400>   311
Met His Ala Lys Met Arg Asn Lys Lys Gln Ile Asn Leu Gly Ile Ile 
1               5                   10                  15      

Phe Val Ile Cys Leu Gly Leu Leu Ile Thr Ile Phe Leu Ser Leu Lys 
            20                  25                  30          

Leu Gly Thr Lys Glu Ile Asn Ile Arg Asp Phe Leu Ala Ala Phe Gly 
        35                  40                  45              

Met Gly Asn Thr Asn Asp Asp Phe Ile Lys Ser Ile Ile Tyr Lys Arg 
    50                  55                  60                  

Ile Pro Arg Thr Ile Phe Ala Ile Leu Ala Gly Ser Ser Leu Ala Ile 
65                  70                  75                  80  

Ser Gly Val Leu Met Gln Ser Val Thr Arg Asn Pro Ile Ala Asp Pro 
                85                  90                  95      

Gly Ile Leu Gly Ile Asn Thr Gly Ala Ser Leu Ser Val Val Ile Gly 
            100                 105                 110         

Leu Ser Phe Leu Gly Ile Ser Ser Ser Ile Ser His Ile Ser Phe Ala 
        115                 120                 125             

Ile Ile Gly Gly Leu Val Ser Ala Ile Phe Val Tyr Ala Ile Ala Val 
    130                 135                 140                 

Ser Gly Lys Ala Gly Leu Thr Pro Ile Lys Leu Ala Leu Ser Gly Thr 
145                 150                 155                 160 

Cys Val Ser Met Ala Leu Ser Ser Phe Val Ser Phe Leu Ile Leu Pro 
                165                 170                 175     

Asn Asn Asn Val Leu Asp Lys Phe Arg Phe Trp Gln Ile Gly Ser Leu 
            180                 185                 190         

Gly Ala Ala Thr Leu Ser Ser Ile Ser Thr Leu Leu Pro Phe Ile Ile 
        195                 200                 205             

Leu Gly His Leu Ile Ala Ile Phe Ile Ser Ser Asp Leu Asn Ala Leu 
    210                 215                 220                 

Ala Met Gly Asp Glu Met Ala Val Gly Leu Gly Val Asn Val Asn Arg 
225                 230                 235                 240 

Ile Arg Ser Leu Ala Ile Ile Ala Ser Val Leu Leu Cys Ser Ser Ile 
                245                 250                 255     

Thr Ala Ile Gly Gly Pro Ile Gly Phe Val Gly Leu Ile Val Pro His 
            260                 265                 270         

Phe Cys Gly Leu Phe Ile Ser Lys Asp Ile Arg Thr Met Thr Ile Ser 
        275                 280                 285             

Ser Ala Phe Ile Gly Ala Glu Leu Leu Leu Ile Cys Asp Ile Ile Gly 
    290                 295                 300                 

Arg Met Leu Gly Lys Pro Gly Glu Ile Glu Val Gly Ile Ile Thr Ala 
305                 310                 315                 320 

Ile Ile Gly Gly Pro Val Leu Ile Tyr Val Thr Met Lys Asn Arg Gly 
                325                 330                 335     

Val Asn Thr 
            

<210>   312
<211>   321
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length PiuA

<400>   312
Met Lys Thr Ser Leu Lys Leu Tyr Phe Thr Ala Leu Val Ala Ser Phe 
1               5                   10                  15      

Leu Leu Leu Leu Gly Ala Cys Ser Thr Asn Ser Ser Thr Ser Gln Thr 
            20                  25                  30          

Glu Thr Ser Ser Ser Ala Pro Thr Glu Ile Thr Ile Lys Ser Ser Leu 
        35                  40                  45              

Asp Glu Val Lys Leu Ser Lys Val Pro Glu Lys Ile Val Thr Phe Asp 
    50                  55                  60                  

Leu Gly Ala Ala Asp Thr Ile Arg Ala Leu Gly Phe Glu Lys Asn Ile 
65                  70                  75                  80  

Val Gly Met Pro Thr Lys Thr Val Pro Thr Tyr Leu Lys Asp Leu Val 
                85                  90                  95      

Gly Thr Val Lys Asn Val Gly Ser Met Lys Glu Pro Asp Leu Glu Ala 
            100                 105                 110         

Ile Ala Ala Leu Glu Pro Asp Leu Ile Ile Ala Ser Pro Arg Thr Gln 
        115                 120                 125             

Lys Phe Val Asp Lys Phe Lys Glu Ile Ala Pro Thr Val Leu Phe Gln 
    130                 135                 140                 

Ala Ser Lys Asp Asp Tyr Trp Thr Ser Thr Lys Ala Asn Ile Glu Ser 
145                 150                 155                 160 

Leu Ala Ser Ala Phe Gly Glu Thr Ser Thr Gln Lys Ala Lys Glu Glu 
                165                 170                 175     

Leu Ala Lys Leu Asp Lys Ser Ile Gln Glu Val Ala Thr Lys Asn Glu 
            180                 185                 190         

Ser Ser Asp Lys Lys Ala Leu Ala Ile Leu Leu Asn Glu Gly Lys Met 
        195                 200                 205             

Ala Ala Phe Gly Ala Lys Ser Arg Phe Ser Phe Leu Tyr Gln Thr Leu 
    210                 215                 220                 

Lys Phe Lys Pro Thr Asp Thr Lys Phe Glu Asp Ser Arg His Gly Gln 
225                 230                 235                 240 

Glu Val Ser Phe Glu Ser Val Lys Glu Ile Asn Pro Asp Ile Leu Phe 
                245                 250                 255     

Val Ile Asn Arg Thr Leu Ala Ile Gly Gly Asp Asn Ser Ser Asn Asp 
            260                 265                 270         

Gly Val Leu Glu Asn Ala Leu Ile Ala Glu Thr Pro Ala Ala Lys Asn 
        275                 280                 285             

Gly Lys Ile Ile Gln Leu Thr Pro Asp Leu Trp Tyr Leu Ser Gly Gly 
    290                 295                 300                 

Gly Leu Glu Ser Thr Lys Leu Met Ile Glu Asp Ile Gln Lys Ala Leu 
305                 310                 315                 320 

Lys 
    

<210>   313
<211>   279
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   full length CbiO

<400>   313
Met Gly Ile Ala Leu Glu Asn Val Asn Phe Ile Tyr Gln Glu Gly Thr 
1               5                   10                  15      

Pro Leu Ala Ser Ala Ala Leu Ser Asp Val Ser Leu Thr Ile Glu Asp 
            20                  25                  30          

Gly Ser Tyr Thr Ala Leu Ile Gly His Thr Gly Ser Gly Lys Ser Thr 
        35                  40                  45              

Ile Leu Gln Leu Leu Asn Gly Leu Leu Val Pro Ser Gln Gly Ser Val 
    50                  55                  60                  

Arg Val Phe Asp Thr Leu Ile Thr Ser Thr Ser Lys Asn Lys Asp Ile 
65                  70                  75                  80  

Arg Gln Ile Arg Lys Gln Val Gly Leu Val Phe Gln Phe Ala Glu Asn 
                85                  90                  95      

Gln Ile Phe Glu Glu Thr Val Leu Lys Asp Val Ala Phe Gly Pro Gln 
            100                 105                 110         

Asn Phe Gly Val Ser Glu Glu Asp Ala Val Lys Thr Ala Arg Glu Lys 
        115                 120                 125             

Leu Ala Leu Val Gly Ile Asp Glu Ser Leu Phe Asp Arg Ser Pro Phe 
    130                 135                 140                 

Glu Leu Ser Gly Gly Gln Met Arg Arg Val Ala Ile Ala Gly Ile Leu 
145                 150                 155                 160 

Ala Met Glu Pro Ser Ile Leu Val Leu Asp Glu Pro Thr Ala Gly Leu 
                165                 170                 175     

Asp Pro Leu Gly Arg Lys Glu Leu Met Thr Leu Phe Lys Lys Leu His 
            180                 185                 190         

Gln Ser Gly Met Thr Ile Val Leu Val Thr His Leu Met Asp Asp Val 
        195                 200                 205             

Ala Glu Tyr Ala Asn Gln Val Tyr Val Met Glu Lys Gly Arg Leu Val 
    210                 215                 220                 

Lys Gly Gly Lys Pro Ser Asp Val Phe Gln Asp Val Val Phe Met Glu 
225                 230                 235                 240 

Glu Val Gln Leu Gly Val Pro Lys Ile Thr Ala Phe Cys Lys Arg Leu 
                245                 250                 255     

Ala Asp Arg Gly Val Ser Phe Lys Arg Leu Pro Ile Lys Ile Glu Glu 
            260                 265                 270         

Phe Lys Glu Ser Leu Asn Gly 
        275                 

<210>   314
<211>   132
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   30S ribosomal protein S8

<400>   314
Met Val Met Thr Asp Pro Ile Ala Asp Phe Leu Thr Arg Ile Arg Asn 
1               5                   10                  15      

Ala Asn Gln Ala Lys His Glu Val Leu Glu Val Pro Ala Ser Asn Ile 
            20                  25                  30          

Lys Lys Gly Ile Ala Glu Ile Leu Lys Arg Glu Gly Phe Val Lys Asn 
        35                  40                  45              

Val Glu Ile Ile Glu Asp Asp Lys Gln Gly Val Ile Arg Val Phe Leu 
    50                  55                  60                  

Lys Tyr Gly Pro Asn Gly Glu Lys Val Ile Thr Asn Leu Lys Arg Val 
65                  70                  75                  80  

Ser Lys Pro Gly Leu Arg Val Tyr Lys Lys Arg Glu Asp Leu Pro Lys 
                85                  90                  95      

Val Leu Asn Gly Leu Gly Ile Ala Ile Leu Ser Thr Ser Glu Gly Leu 
            100                 105                 110         

Leu Thr Asp Lys Glu Ala Arg Gln Lys Asn Val Gly Gly Glu Val Ile 
        115                 120                 125             

Ala Tyr Val Trp 
    130         

<210>   315
<211>   26
<212>   DNA
<213>   Artificial

<220>
<223>   deoxynucleotide comprising 26-mer sequence 5'-(IC)13-3'

<220>
<221>   misc_feature
<222>   (1), (3), (5), (7), (9), (11), (13), (15), (17), (19), (21), (23), (25)
<223>   n = inosine

<400>   315
ncncncncnc ncncncncnc ncncnc                                        26

<210>   316
<211>   11
<212>   PRT
<213>   Artificial

<220>
<223>   polycationic peptide comprising 11-mer amino acid sequence

<400>   316
Lys Leu Lys Leu Leu Leu Leu Leu Lys Leu Lys 
1               5                   10      

<210>   317
<211>   1427
<212>   PRT
<213>   Artificial

<220>
<223>   hybrid protein; spr0057 and spr0096

<400>   317
Met Ala Asp Gly Val Thr Pro Thr Thr Thr Glu Asn Gln Pro Thr Ile 
1               5                   10                  15      

His Thr Val Ser Asp Ser Pro Gln Ser Ser Glu Asn Arg Thr Glu Glu 
            20                  25                  30          

Thr Pro Lys Ala Val Leu Gln Pro Glu Ala Pro Lys Thr Val Glu Thr 
        35                  40                  45              

Glu Thr Pro Ala Thr Asp Lys Val Ala Ser Leu Pro Lys Thr Glu Glu 
    50                  55                  60                  

Lys Pro Gln Glu Glu Val Ser Ser Thr Pro Ser Asp Lys Ala Glu Val 
65                  70                  75                  80  

Val Thr Pro Thr Ser Ala Glu Lys Glu Thr Ala Asn Lys Lys Ala Glu 
                85                  90                  95      

Glu Ala Ser Pro Lys Lys Glu Glu Ala Lys Glu Val Asp Ser Lys Glu 
            100                 105                 110         

Ser Asn Thr Asp Lys Thr Asp Lys Asp Lys Pro Ala Lys Lys Asp Glu 
        115                 120                 125             

Ala Lys Ala Glu Ala Asp Lys Pro Ala Thr Glu Ala Gly Lys Glu Arg 
    130                 135                 140                 

Ala Ala Thr Val Asn Glu Lys Leu Ala Lys Lys Lys Ile Val Ser Ile 
145                 150                 155                 160 

Asp Ala Gly Arg Lys Tyr Phe Ser Pro Glu Gln Leu Lys Glu Ile Ile 
                165                 170                 175     

Asp Lys Ala Lys His Tyr Gly Tyr Thr Asp Leu His Leu Leu Val Gly 
            180                 185                 190         

Asn Asp Gly Leu Arg Phe Met Leu Asp Asp Met Ser Ile Thr Ala Asn 
        195                 200                 205             

Gly Lys Thr Tyr Ala Ser Asp Asp Val Lys Arg Ala Ile Glu Lys Gly 
    210                 215                 220                 

Thr Asn Asp Tyr Tyr Asn Asp Pro Asn Gly Asn His Leu Thr Glu Ser 
225                 230                 235                 240 

Gln Met Thr Asp Leu Ile Asn Tyr Ala Lys Asp Lys Gly Ile Gly Leu 
                245                 250                 255     

Ile Pro Thr Val Asn Ser Pro Gly His Met Asp Ala Ile Leu Asn Ala 
            260                 265                 270         

Met Lys Glu Leu Gly Ile Gln Asn Pro Asn Phe Ser Tyr Phe Gly Lys 
        275                 280                 285             

Lys Ser Ala Arg Thr Val Asp Leu Asp Asn Glu Gln Ala Val Ala Phe 
    290                 295                 300                 

Thr Lys Ala Leu Ile Asp Lys Tyr Ala Ala Tyr Phe Ala Lys Lys Thr 
305                 310                 315                 320 

Glu Ile Phe Asn Ile Gly Leu Asp Glu Tyr Ala Asn Asp Ala Thr Asp 
                325                 330                 335     

Ala Lys Gly Trp Ser Val Leu Gln Ala Asp Lys Tyr Tyr Pro Asn Glu 
            340                 345                 350         

Gly Tyr Pro Val Lys Gly Tyr Glu Lys Phe Ile Ala Tyr Ala Asn Asp 
        355                 360                 365             

Leu Ala Arg Ile Val Lys Ser His Gly Leu Lys Pro Met Ala Phe Asn 
    370                 375                 380                 

Asp Gly Ile Tyr Tyr Asn Ser Asp Thr Ser Phe Gly Ser Phe Asp Lys 
385                 390                 395                 400 

Asp Ile Ile Val Ser Met Trp Thr Gly Gly Trp Gly Gly Tyr Asp Val 
                405                 410                 415     

Ala Ser Ser Lys Leu Leu Ala Glu Lys Gly His Gln Ile Leu Asn Thr 
            420                 425                 430         

Asn Asp Ala Trp Tyr Tyr Val Leu Gly Arg Asn Ala Asp Gly Gln Gly 
        435                 440                 445             

Trp Tyr Asn Leu Asp Gln Gly Leu Asn Gly Ile Lys Asn Thr Pro Ile 
    450                 455                 460                 

Thr Ser Val Pro Lys Thr Glu Gly Ala Asp Ile Pro Ile Ile Gly Gly 
465                 470                 475                 480 

Met Val Ala Ala Trp Ala Asp Thr Pro Ser Ala Arg Tyr Ser Pro Ser 
                485                 490                 495     

Arg Leu Phe Lys Leu Met Arg His Phe Ala Asn Ala Asn Ala Glu Tyr 
            500                 505                 510         

Phe Ala Ala Asp Tyr Glu Ser Ala Glu Gln Ala Leu Asn Glu Val Pro 
        515                 520                 525             

Lys Asp Leu Asn Arg Tyr Thr Ala Glu Ser Val Thr Ala Val Lys Glu 
    530                 535                 540                 

Ala Glu Lys Ala Ile Arg Ser Leu Asp Ser Asn Leu Ser Arg Ala Gln 
545                 550                 555                 560 

Gln Asp Thr Ile Asp Gln Ala Ile Ala Lys Leu Gln Glu Thr Val Asn 
                565                 570                 575     

Asn Leu Thr Leu Thr Pro Glu Ala Gln Lys Glu Glu Glu Ala Lys Arg 
            580                 585                 590         

Glu Val Glu Lys Leu Ala Lys Asn Lys Val Ile Ser Ile Asp Ala Gly 
        595                 600                 605             

Arg Lys Tyr Phe Thr Leu Asn Gln Leu Lys Arg Ile Val Asp Lys Ala 
    610                 615                 620                 

Ser Glu Leu Gly Tyr Ser Asp Val His Leu Leu Leu Gly Asn Asp Gly 
625                 630                 635                 640 

Leu Arg Phe Leu Leu Asp Asp Met Thr Ile Thr Ala Asn Gly Lys Thr 
                645                 650                 655     

Tyr Ala Ser Asp Asp Val Lys Lys Ala Ile Ile Glu Gly Thr Lys Ala 
            660                 665                 670         

Tyr Tyr Asp Asp Pro Asn Gly Thr Ala Leu Thr Gln Ala Glu Val Thr 
        675                 680                 685             

Glu Leu Ile Glu Tyr Ala Lys Ser Lys Asp Ile Gly Leu Ile Pro Ala 
    690                 695                 700                 

Ile Asn Ser Pro Gly His Met Asp Ala Met Leu Val Ala Met Glu Lys 
705                 710                 715                 720 

Leu Gly Ile Lys Asn Pro Gln Ala His Phe Asp Lys Val Ser Lys Thr 
                725                 730                 735     

Thr Met Asp Leu Lys Asn Glu Glu Ala Met Asn Phe Val Lys Ala Leu 
            740                 745                 750         

Ile Gly Lys Tyr Met Asp Phe Phe Ala Gly Lys Thr Lys Ile Phe Asn 
        755                 760                 765             

Phe Gly Thr Asp Glu Tyr Ala Asn Asp Ala Thr Ser Ala Gln Gly Trp 
    770                 775                 780                 

Tyr Tyr Leu Lys Trp Tyr Gln Leu Tyr Gly Lys Phe Ala Glu Tyr Ala 
785                 790                 795                 800 

Asn Thr Leu Ala Ala Met Ala Lys Glu Arg Gly Leu Gln Pro Met Ala 
                805                 810                 815     

Phe Asn Asp Gly Phe Tyr Tyr Glu Asp Lys Asp Asp Val Gln Phe Asp 
            820                 825                 830         

Lys Asp Val Leu Ile Ser Tyr Trp Ser Lys Gly Trp Trp Gly Tyr Asn 
        835                 840                 845             

Leu Ala Ser Pro Gln Tyr Leu Ala Ser Lys Gly Tyr Lys Phe Leu Asn 
    850                 855                 860                 

Thr Asn Gly Asp Trp Tyr Tyr Ile Leu Gly Gln Lys Pro Glu Asp Gly 
865                 870                 875                 880 

Gly Gly Phe Leu Lys Lys Ala Ile Glu Asn Thr Gly Lys Thr Pro Phe 
                885                 890                 895     

Asn Gln Leu Ala Ser Thr Lys Tyr Pro Glu Val Asp Leu Pro Thr Val 
            900                 905                 910         

Gly Ser Met Leu Ser Ile Trp Ala Asp Arg Pro Ser Ala Glu Tyr Lys 
        915                 920                 925             

Glu Glu Glu Ile Phe Glu Leu Met Thr Ala Phe Ala Asp His Asn Lys 
    930                 935                 940                 

Asp Tyr Phe Arg Ala Asn Tyr Asn Ala Leu Arg Glu Glu Leu Ala Lys 
945                 950                 955                 960 

Ile Pro Thr Asn Leu Glu Gly Tyr Ser Lys Glu Ser Leu Glu Ala Leu 
                965                 970                 975     

Asp Ala Ala Lys Thr Ala Leu Asn Tyr Asn Leu Asn Arg Asn Lys Gln 
            980                 985                 990         

Ala Glu Leu Asp Thr Leu Val Ala Asn Leu Lys Ala Ala Leu Gln Gly 
        995                 1000                1005            

Leu Lys Pro Ala Val Thr His Ser Gly Ser Leu Asp Glu Asn Glu Val 
    1010                1015                1020                

Ala Ala Asn Val Glu Thr Arg Pro Glu Leu Ile Thr Arg Thr Glu Glu 
1025                1030                1035                1040

Ile Pro Phe Glu Val Ile Lys Lys Glu Asn Pro Asn Leu Pro Ala Gly 
                1045                1050                1055    

Gln Glu Asn Ile Ile Thr Ala Gly Val Lys Gly Glu Arg Thr His Tyr 
            1060                1065                1070        

Ile Ser Val Leu Thr Glu Asn Gly Lys Thr Thr Glu Thr Val Leu Asp 
        1075                1080                1085            

Ser Gln Val Thr Lys Glu Val Ile Asn Gln Val Val Glu Val Gly Ala 
    1090                1095                1100                

Pro Val Thr His Lys Gly Asp Glu Ser Gly Leu Ala Pro Thr Thr Glu 
1105                1110                1115                1120

Val Lys Pro Arg Leu Asp Ile Gln Glu Glu Glu Ile Pro Phe Thr Thr 
                1125                1130                1135    

Val Thr Cys Glu Asn Pro Leu Leu Leu Lys Gly Lys Thr Gln Val Ile 
            1140                1145                1150        

Thr Lys Gly Val Asn Gly His Arg Ser Asn Phe Tyr Ser Val Ser Thr 
        1155                1160                1165            

Ser Ala Asp Gly Lys Glu Val Lys Thr Leu Val Asn Ser Val Val Ala 
    1170                1175                1180                

Gln Glu Ala Val Thr Gln Ile Val Glu Val Gly Thr Met Val Thr His 
1185                1190                1195                1200

Val Gly Asp Glu Asn Gly Gln Ala Ala Ile Ala Glu Glu Lys Pro Lys 
                1205                1210                1215    

Leu Glu Ile Pro Ser Gln Pro Ala Pro Ser Thr Ala Pro Ala Glu Glu 
            1220                1225                1230        

Ser Lys Val Leu Pro Gln Asp Pro Ala Pro Val Val Thr Glu Lys Lys 
        1235                1240                1245            

Gly Ser Gly Ser Gly Gly Gly Gly Val Ser Ala Gln Glu Ser Ser Thr 
    1250                1255                1260                

Tyr Thr Val Lys Glu Gly Asp Thr Leu Ser Glu Ile Ala Glu Thr His 
1265                1270                1275                1280

Asn Thr Thr Val Glu Lys Leu Ala Glu Asn Asn His Ile Asp Asn Ile 
                1285                1290                1295    

His Leu Ile Tyr Val Asp Gln Glu Leu Val Ile Asp Gly Pro Val Ala 
            1300                1305                1310        

Pro Val Ala Thr Pro Ala Pro Ala Thr Tyr Ala Ala Pro Ala Ala Gln 
        1315                1320                1325            

Asp Glu Thr Val Ser Ala Pro Val Ala Glu Thr Pro Val Val Ser Glu 
    1330                1335                1340                

Thr Val Val Ser Thr Val Ser Gly Ser Glu Ala Glu Ala Lys Glu Trp 
1345                1350                1355                1360

Ile Ala Gln Lys Glu Ser Gly Gly Ser Tyr Thr Ala Thr Asn Gly Arg 
                1365                1370                1375    

Tyr Ile Gly Arg Tyr Gln Leu Thr Asp Ser Tyr Leu Asn Gly Asp Tyr 
            1380                1385                1390        

Ser Ala Glu Asn Gln Glu Arg Val Ala Asp Ala Tyr Val Ala Gly Arg 
        1395                1400                1405            

Tyr Gly Ser Trp Thr Ala Ala Lys Asn Phe Trp Leu Asn Asn Gly Trp 
    1410                1415                1420                

Tyr Leu Glu 
1425        

<210>   318
<211>   1242
<212>   PRT
<213>   Artificial

<220>
<223>   hybrid protein; spr0057 and spr0096

<400>   318
Met Leu His Leu Leu Val Gly Asn Asp Gly Leu Arg Phe Met Leu Asp 
1               5                   10                  15      

Asp Met Ser Ile Thr Ala Asn Gly Lys Thr Tyr Ala Ser Asp Asp Val 
            20                  25                  30          

Lys Arg Ala Ile Glu Lys Gly Thr Asn Asp Tyr Tyr Asn Asp Pro Asn 
        35                  40                  45              

Gly Asn His Leu Thr Glu Ser Gln Met Thr Asp Leu Ile Asn Tyr Ala 
    50                  55                  60                  

Lys Asp Lys Gly Ile Gly Leu Ile Pro Thr Val Asn Ser Pro Gly His 
65                  70                  75                  80  

Met Asp Ala Ile Leu Asn Ala Met Lys Glu Leu Gly Ile Gln Asn Pro 
                85                  90                  95      

Asn Phe Ser Tyr Phe Gly Lys Lys Ser Ala Arg Thr Val Asp Leu Asp 
            100                 105                 110         

Asn Glu Gln Ala Val Ala Phe Thr Lys Ala Leu Ile Asp Lys Tyr Ala 
        115                 120                 125             

Ala Tyr Phe Ala Lys Lys Thr Glu Ile Phe Asn Ile Gly Leu Asp Glu 
    130                 135                 140                 

Tyr Ala Asn Asp Ala Thr Asp Ala Lys Gly Trp Ser Val Leu Gln Ala 
145                 150                 155                 160 

Asp Lys Tyr Tyr Pro Asn Glu Gly Tyr Pro Val Lys Gly Tyr Glu Lys 
                165                 170                 175     

Phe Ile Ala Tyr Ala Asn Asp Leu Ala Arg Ile Val Lys Ser His Gly 
            180                 185                 190         

Leu Lys Pro Met Ala Phe Asn Asp Gly Ile Tyr Tyr Asn Ser Asp Thr 
        195                 200                 205             

Ser Phe Gly Ser Phe Asp Lys Asp Ile Ile Val Ser Met Trp Thr Gly 
    210                 215                 220                 

Gly Trp Gly Gly Tyr Asp Val Ala Ser Ser Lys Leu Leu Ala Glu Lys 
225                 230                 235                 240 

Gly His Gln Ile Leu Asn Thr Asn Asp Ala Trp Tyr Tyr Val Leu Gly 
                245                 250                 255     

Arg Asn Ala Asp Gly Gln Gly Trp Tyr Asn Leu Asp Gln Gly Leu Asn 
            260                 265                 270         

Gly Ile Lys Asn Thr Pro Ile Thr Ser Val Pro Lys Thr Glu Gly Ala 
        275                 280                 285             

Asp Ile Pro Ile Ile Gly Gly Met Val Ala Ala Trp Ala Asp Thr Pro 
    290                 295                 300                 

Ser Ala Arg Tyr Ser Pro Ser Arg Leu Phe Lys Leu Met Arg His Phe 
305                 310                 315                 320 

Ala Asn Ala Asn Ala Glu Tyr Phe Ala Ala Asp Tyr Glu Ser Ala Glu 
                325                 330                 335     

Gln Ala Leu Asn Glu Val Pro Lys Asp Leu Asn Arg Tyr Thr Ala Glu 
            340                 345                 350         

Ser Val Thr Ala Val Lys Glu Ala Glu Lys Ala Ile Arg Ser Leu Asp 
        355                 360                 365             

Ser Asn Leu Ser Arg Ala Gln Gln Asp Thr Ile Asp Gln Ala Ile Ala 
    370                 375                 380                 

Lys Leu Gln Glu Thr Val Asn Asn Leu Thr Leu Thr Pro Glu Ala Gln 
385                 390                 395                 400 

Lys Glu Glu Glu Ala Lys Arg Glu Val Glu Lys Leu Ala Lys Asn Lys 
                405                 410                 415     

Val Ile Ser Ile Asp Ala Gly Arg Lys Tyr Phe Thr Leu Asn Gln Leu 
            420                 425                 430         

Lys Arg Ile Val Asp Lys Ala Ser Glu Leu Gly Tyr Ser Asp Val His 
        435                 440                 445             

Leu Leu Leu Gly Asn Asp Gly Leu Arg Phe Leu Leu Asp Asp Met Thr 
    450                 455                 460                 

Ile Thr Ala Asn Gly Lys Thr Tyr Ala Ser Asp Asp Val Lys Lys Ala 
465                 470                 475                 480 

Ile Ile Glu Gly Thr Lys Ala Tyr Tyr Asp Asp Pro Asn Gly Thr Ala 
                485                 490                 495     

Leu Thr Gln Ala Glu Val Thr Glu Leu Ile Glu Tyr Ala Lys Ser Lys 
            500                 505                 510         

Asp Ile Gly Leu Ile Pro Ala Ile Asn Ser Pro Gly His Met Asp Ala 
        515                 520                 525             

Met Leu Val Ala Met Glu Lys Leu Gly Ile Lys Asn Pro Gln Ala His 
    530                 535                 540                 

Phe Asp Lys Val Ser Lys Thr Thr Met Asp Leu Lys Asn Glu Glu Ala 
545                 550                 555                 560 

Met Asn Phe Val Lys Ala Leu Ile Gly Lys Tyr Met Asp Phe Phe Ala 
                565                 570                 575     

Gly Lys Thr Lys Ile Phe Asn Phe Gly Thr Asp Glu Tyr Ala Asn Asp 
            580                 585                 590         

Ala Thr Ser Ala Gln Gly Trp Tyr Tyr Leu Lys Trp Tyr Gln Leu Tyr 
        595                 600                 605             

Gly Lys Phe Ala Glu Tyr Ala Asn Thr Leu Ala Ala Met Ala Lys Glu 
    610                 615                 620                 

Arg Gly Leu Gln Pro Met Ala Phe Asn Asp Gly Phe Tyr Tyr Glu Asp 
625                 630                 635                 640 

Lys Asp Asp Val Gln Phe Asp Lys Asp Val Leu Ile Ser Tyr Trp Ser 
                645                 650                 655     

Lys Gly Trp Trp Gly Tyr Asn Leu Ala Ser Pro Gln Tyr Leu Ala Ser 
            660                 665                 670         

Lys Gly Tyr Lys Phe Leu Asn Thr Asn Gly Asp Trp Tyr Tyr Ile Leu 
        675                 680                 685             

Gly Gln Lys Pro Glu Asp Gly Gly Gly Phe Leu Lys Lys Ala Ile Glu 
    690                 695                 700                 

Asn Thr Gly Lys Thr Pro Phe Asn Gln Leu Ala Ser Thr Lys Tyr Pro 
705                 710                 715                 720 

Glu Val Asp Leu Pro Thr Val Gly Ser Met Leu Ser Ile Trp Ala Asp 
                725                 730                 735     

Arg Pro Ser Ala Glu Tyr Lys Glu Glu Glu Ile Phe Glu Leu Met Thr 
            740                 745                 750         

Ala Phe Ala Asp His Asn Lys Asp Tyr Phe Arg Ala Asn Tyr Asn Ala 
        755                 760                 765             

Leu Arg Glu Glu Leu Ala Lys Ile Pro Thr Asn Leu Glu Gly Tyr Ser 
    770                 775                 780                 

Lys Glu Ser Leu Glu Ala Leu Asp Ala Ala Lys Thr Ala Leu Asn Tyr 
785                 790                 795                 800 

Asn Leu Asn Arg Asn Lys Gln Ala Glu Leu Asp Thr Leu Val Ala Asn 
                805                 810                 815     

Leu Lys Ala Ala Leu Gln Gly Leu Lys Pro Ala Val Thr His Ser Gly 
            820                 825                 830         

Ser Leu Asp Glu Asn Glu Val Ala Ala Asn Val Glu Thr Arg Pro Glu 
        835                 840                 845             

Leu Ile Thr Arg Thr Glu Glu Ile Pro Phe Glu Val Ile Lys Lys Glu 
    850                 855                 860                 

Asn Pro Asn Leu Pro Ala Gly Gln Glu Asn Ile Ile Thr Ala Gly Val 
865                 870                 875                 880 

Lys Gly Glu Arg Thr His Tyr Ile Ser Val Leu Thr Glu Asn Gly Lys 
                885                 890                 895     

Thr Thr Glu Thr Val Leu Asp Ser Gln Val Thr Lys Glu Val Ile Asn 
            900                 905                 910         

Gln Val Val Glu Val Gly Ala Pro Val Thr His Lys Gly Asp Glu Ser 
        915                 920                 925             

Gly Leu Ala Pro Thr Thr Glu Val Lys Pro Arg Leu Asp Ile Gln Glu 
    930                 935                 940                 

Glu Glu Ile Pro Phe Thr Thr Val Thr Cys Glu Asn Pro Leu Leu Leu 
945                 950                 955                 960 

Lys Gly Lys Thr Gln Val Ile Thr Lys Gly Val Asn Gly His Arg Ser 
                965                 970                 975     

Asn Phe Tyr Ser Val Ser Thr Ser Ala Asp Gly Lys Glu Val Lys Thr 
            980                 985                 990         

Leu Val Asn Ser Val Val Ala Gln Glu Ala Val Thr Gln Ile Val Glu 
        995                 1000                1005            

Val Gly Thr Met Val Thr His Val Gly Asp Glu Asn Gly Gln Ala Ala 
    1010                1015                1020                

Ile Ala Glu Glu Lys Pro Lys Leu Glu Ile Pro Ser Gln Pro Ala Pro 
1025                1030                1035                1040

Ser Thr Ala Pro Ala Glu Glu Ser Lys Val Leu Pro Gln Asp Pro Ala 
                1045                1050                1055    

Pro Val Val Thr Glu Lys Lys Gly Ser Gly Ser Gly Gly Gly Gly Val 
            1060                1065                1070        

Ser Ala Gln Glu Ser Ser Thr Tyr Thr Val Lys Glu Gly Asp Thr Leu 
        1075                1080                1085            

Ser Glu Ile Ala Glu Thr His Asn Thr Thr Val Glu Lys Leu Ala Glu 
    1090                1095                1100                

Asn Asn His Ile Asp Asn Ile His Leu Ile Tyr Val Asp Gln Glu Leu 
1105                1110                1115                1120

Val Ile Asp Gly Pro Val Ala Pro Val Ala Thr Pro Ala Pro Ala Thr 
                1125                1130                1135    

Tyr Ala Ala Pro Ala Ala Gln Asp Glu Thr Val Ser Ala Pro Val Ala 
            1140                1145                1150        

Glu Thr Pro Val Val Ser Glu Thr Val Val Ser Thr Val Ser Gly Ser 
        1155                1160                1165            

Glu Ala Glu Ala Lys Glu Trp Ile Ala Gln Lys Glu Ser Gly Gly Ser 
    1170                1175                1180                

Tyr Thr Ala Thr Asn Gly Arg Tyr Ile Gly Arg Tyr Gln Leu Thr Asp 
1185                1190                1195                1200

Ser Tyr Leu Asn Gly Asp Tyr Ser Ala Glu Asn Gln Glu Arg Val Ala 
                1205                1210                1215    

Asp Ala Tyr Val Ala Gly Arg Tyr Gly Ser Trp Thr Ala Ala Lys Asn 
            1220                1225                1230        

Phe Trp Leu Asn Asn Gly Trp Tyr Leu Glu 
        1235                1240        

<210>   319
<211>   549
<212>   PRT
<213>   Artificial

<220>
<223>   hybrid protein; spr0096 and spr2021

<400>   319
Met Val Ser Ala Gln Glu Ser Ser Thr Tyr Thr Val Lys Glu Gly Asp 
1               5                   10                  15      

Thr Leu Ser Glu Ile Ala Glu Thr His Asn Thr Thr Val Glu Lys Leu 
            20                  25                  30          

Ala Glu Asn Asn His Ile Asp Asn Ile His Leu Ile Tyr Val Asp Gln 
        35                  40                  45              

Glu Leu Val Ile Asp Gly Pro Val Ala Pro Val Ala Thr Pro Ala Pro 
    50                  55                  60                  

Ala Thr Tyr Ala Ala Pro Ala Ala Gln Asp Glu Thr Val Ser Ala Pro 
65                  70                  75                  80  

Val Ala Glu Thr Pro Val Val Ser Glu Thr Val Val Ser Thr Val Ser 
                85                  90                  95      

Gly Ser Glu Ala Glu Ala Lys Glu Trp Ile Ala Gln Lys Glu Ser Gly 
            100                 105                 110         

Gly Ser Tyr Thr Ala Thr Asn Gly Arg Tyr Ile Gly Arg Tyr Gln Leu 
        115                 120                 125             

Thr Asp Ser Tyr Leu Asn Gly Asp Tyr Ser Ala Glu Asn Gln Glu Arg 
    130                 135                 140                 

Val Ala Asp Ala Tyr Val Ala Gly Arg Tyr Gly Ser Trp Thr Ala Ala 
145                 150                 155                 160 

Lys Asn Phe Trp Leu Asn Asn Gly Trp Tyr Gly Ser Gly Ser Gly Gly 
                165                 170                 175     

Gly Gly Ala Glu Thr Thr Asp Asp Lys Ile Ala Ala Gln Asp Asn Lys 
            180                 185                 190         

Ile Ser Asn Leu Thr Ala Gln Gln Gln Glu Ala Gln Lys Gln Val Asp 
        195                 200                 205             

Gln Ile Gln Glu Gln Val Ser Ala Ile Gln Ala Glu Gln Ser Asn Leu 
    210                 215                 220                 

Gln Ala Glu Asn Asp Arg Leu Gln Ala Glu Ser Lys Lys Leu Glu Gly 
225                 230                 235                 240 

Glu Ile Thr Glu Leu Ser Lys Asn Ile Val Ser Arg Asn Gln Ser Leu 
                245                 250                 255     

Glu Lys Gln Ala Arg Ser Ala Gln Thr Asn Gly Ala Val Thr Ser Tyr 
            260                 265                 270         

Ile Asn Thr Ile Val Asn Ser Lys Ser Ile Thr Glu Ala Ile Ser Arg 
        275                 280                 285             

Val Ala Ala Met Ser Glu Ile Val Ser Ala Asn Asn Lys Met Leu Glu 
    290                 295                 300                 

Gln Gln Lys Ala Asp Lys Lys Ala Ile Ser Glu Lys Gln Val Ala Asn 
305                 310                 315                 320 

Asn Asp Ala Ile Asn Thr Val Ile Ala Asn Gln Gln Lys Leu Ala Asp 
                325                 330                 335     

Asp Ala Gln Ala Leu Thr Thr Lys Gln Ala Glu Leu Lys Ala Ala Glu 
            340                 345                 350         

Leu Ser Leu Ala Ala Glu Lys Ala Thr Ala Glu Gly Glu Lys Ala Ser 
        355                 360                 365             

Leu Leu Glu Gln Lys Ala Ala Ala Glu Ala Glu Ala Arg Ala Ala Ala 
    370                 375                 380                 

Val Ala Glu Ala Ala Tyr Lys Glu Lys Arg Ala Ser Gln Gln Gln Ser 
385                 390                 395                 400 

Val Leu Ala Ser Ala Asn Thr Asn Leu Thr Ala Gln Val Gln Ala Val 
                405                 410                 415     

Ser Glu Ser Ala Ala Ala Pro Val Arg Ala Lys Val Arg Pro Thr Tyr 
            420                 425                 430         

Ser Thr Asn Ala Ser Ser Tyr Pro Ile Gly Glu Cys Thr Trp Gly Val 
        435                 440                 445             

Lys Thr Leu Ala Pro Trp Ala Gly Asp Tyr Trp Gly Asn Gly Ala Gln 
    450                 455                 460                 

Trp Ala Thr Ser Ala Ala Ala Ala Gly Phe Arg Thr Gly Ser Thr Pro 
465                 470                 475                 480 

Gln Val Gly Ala Ile Ala Cys Trp Asn Asp Gly Gly Tyr Gly His Val 
                485                 490                 495     

Ala Val Val Thr Ala Val Glu Ser Thr Thr Arg Ile Gln Val Ser Glu 
            500                 505                 510         

Ser Asn Tyr Ala Gly Asn Arg Thr Ile Gly Asn His Arg Gly Trp Phe 
        515                 520                 525             

Asn Pro Thr Thr Thr Ser Glu Gly Phe Val Thr Tyr Ile Tyr Ala Asp 
    530                 535                 540                 

Ala Ala Ala Leu Glu 
545                 

<210>   320
<211>   665
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   RrgB sequence

<400>   320
Met Lys Ser Ile Asn Lys Phe Leu Thr Met Leu Ala Ala Leu Leu Leu 
1               5                   10                  15      

Thr Ala Ser Ser Leu Phe Ser Ala Ala Thr Val Phe Ala Ala Gly Thr 
            20                  25                  30          

Thr Thr Thr Ser Val Thr Val His Lys Leu Leu Ala Thr Asp Gly Asp 
        35                  40                  45              

Met Asp Lys Ile Ala Asn Glu Leu Glu Thr Gly Asn Tyr Ala Gly Asn 
    50                  55                  60                  

Lys Val Gly Val Leu Pro Ala Asn Ala Lys Glu Ile Ala Gly Val Met 
65                  70                  75                  80  

Phe Val Trp Thr Asn Thr Asn Asn Glu Ile Ile Asp Glu Asn Gly Gln 
                85                  90                  95      

Thr Leu Gly Val Asn Ile Asp Pro Gln Thr Phe Lys Leu Ser Gly Ala 
            100                 105                 110         

Met Pro Ala Thr Ala Met Lys Lys Leu Thr Glu Ala Glu Gly Ala Lys 
        115                 120                 125             

Phe Asn Thr Ala Asn Leu Pro Ala Ala Lys Tyr Lys Ile Tyr Glu Ile 
    130                 135                 140                 

His Ser Leu Ser Thr Tyr Val Gly Glu Asp Gly Ala Thr Leu Thr Gly 
145                 150                 155                 160 

Ser Lys Ala Val Pro Ile Glu Ile Glu Leu Pro Leu Asn Asp Val Val 
                165                 170                 175     

Asp Ala His Val Tyr Pro Lys Asn Thr Glu Ala Lys Pro Lys Ile Asp 
            180                 185                 190         

Lys Asp Phe Lys Gly Lys Ala Asn Pro Asp Thr Pro Arg Val Asp Lys 
        195                 200                 205             

Asp Thr Pro Val Asn His Gln Val Gly Asp Val Val Glu Tyr Glu Ile 
    210                 215                 220                 

Val Thr Lys Ile Pro Ala Leu Ala Asn Tyr Ala Thr Ala Asn Trp Ser 
225                 230                 235                 240 

Asp Arg Met Thr Glu Gly Leu Ala Phe Asn Lys Gly Thr Val Lys Val 
                245                 250                 255     

Thr Val Asp Asp Val Ala Leu Glu Ala Gly Asp Tyr Ala Leu Thr Glu 
            260                 265                 270         

Val Ala Thr Gly Phe Asp Leu Lys Leu Thr Asp Ala Gly Leu Ala Lys 
        275                 280                 285             

Val Asn Asp Gln Asn Ala Glu Lys Thr Val Lys Ile Thr Tyr Ser Ala 
    290                 295                 300                 

Thr Leu Asn Asp Lys Ala Ile Val Glu Val Pro Glu Ser Asn Asp Val 
305                 310                 315                 320 

Thr Phe Asn Tyr Gly Asn Asn Pro Asp His Gly Asn Thr Pro Lys Pro 
                325                 330                 335     

Asn Lys Pro Asn Glu Asn Gly Asp Leu Thr Leu Thr Lys Thr Trp Val 
            340                 345                 350         

Asp Ala Thr Gly Ala Pro Ile Pro Ala Gly Ala Glu Ala Thr Phe Asp 
        355                 360                 365             

Leu Val Asn Ala Gln Thr Gly Lys Val Val Gln Thr Val Thr Leu Thr 
    370                 375                 380                 

Thr Asp Lys Asn Thr Val Thr Val Asn Gly Leu Asp Lys Asn Thr Glu 
385                 390                 395                 400 

Tyr Lys Phe Val Glu Arg Ser Ile Lys Gly Tyr Ser Ala Asp Tyr Gln 
                405                 410                 415     

Glu Ile Thr Thr Ala Gly Glu Ile Ala Val Lys Asn Trp Lys Asp Glu 
            420                 425                 430         

Asn Pro Lys Pro Leu Asp Pro Thr Glu Pro Lys Val Val Thr Tyr Gly 
        435                 440                 445             

Lys Lys Phe Val Lys Val Asn Asp Lys Asp Asn Arg Leu Ala Gly Ala 
    450                 455                 460                 

Glu Phe Val Ile Ala Asn Ala Asp Asn Ala Gly Gln Tyr Leu Ala Arg 
465                 470                 475                 480 

Lys Ala Asp Lys Val Ser Gln Glu Glu Lys Gln Leu Val Val Thr Thr 
                485                 490                 495     

Lys Asp Ala Leu Asp Arg Ala Val Ala Ala Tyr Asn Ala Leu Thr Ala 
            500                 505                 510         

Gln Gln Gln Thr Gln Gln Glu Lys Glu Lys Val Asp Lys Ala Gln Ala 
        515                 520                 525             

Ala Tyr Asn Ala Ala Val Ile Ala Ala Asn Asn Ala Phe Glu Trp Val 
    530                 535                 540                 

Ala Asp Lys Asp Asn Glu Asn Val Val Lys Leu Val Ser Asp Ala Gln 
545                 550                 555                 560 

Gly Arg Phe Glu Ile Thr Gly Leu Leu Ala Gly Thr Tyr Tyr Leu Glu 
                565                 570                 575     

Glu Thr Lys Gln Pro Ala Gly Tyr Ala Leu Leu Thr Ser Arg Gln Lys 
            580                 585                 590         

Phe Glu Val Thr Ala Thr Ser Tyr Ser Ala Thr Gly Gln Gly Ile Glu 
        595                 600                 605             

Tyr Thr Ala Gly Ser Gly Lys Asp Asp Ala Thr Lys Val Val Asn Lys 
    610                 615                 620                 

Lys Ile Thr Ile Pro Gln Thr Gly Gly Ile Gly Thr Ile Ile Phe Ala 
625                 630                 635                 640 

Val Ala Gly Ala Val Ile Met Gly Ile Ala Val Tyr Ala Tyr Val Lys 
                645                 650                 655     

Asn Asn Lys Asp Glu Asp Gln Leu Ala 
            660                 665 

<210>   321
<211>   644
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   RrgB sequence

<400>   321
Met Lys Ser Ile Asn Lys Phe Leu Thr Met Leu Ala Ala Leu Leu Leu 
1               5                   10                  15      

Thr Ala Ser Ser Leu Phe Ser Ala Ala Thr Val Phe Ala Ala Asp Asn 
            20                  25                  30          

Val Ser Thr Ala Pro Asp Ala Val Thr Lys Thr Leu Thr Ile His Lys 
        35                  40                  45              

Leu Leu Leu Ser Glu Asp Asp Leu Lys Thr Trp Asp Thr Asn Gly Pro 
    50                  55                  60                  

Lys Gly Tyr Asp Gly Thr Gln Ser Ser Leu Lys Asp Leu Thr Gly Val 
65                  70                  75                  80  

Val Ala Glu Glu Ile Pro Asn Val Tyr Phe Glu Leu Gln Lys Tyr Asn 
                85                  90                  95      

Leu Thr Asp Gly Lys Glu Lys Glu Asn Leu Lys Asp Asp Ser Lys Trp 
            100                 105                 110         

Thr Thr Val His Gly Gly Leu Thr Thr Lys Asp Gly Leu Lys Ile Glu 
        115                 120                 125             

Thr Ser Thr Leu Lys Gly Val Tyr Arg Ile Arg Glu Asp Arg Thr Lys 
    130                 135                 140                 

Thr Thr Tyr Val Gly Pro Asn Gly Gln Val Leu Thr Gly Ser Lys Ala 
145                 150                 155                 160 

Val Pro Ala Leu Val Thr Leu Pro Leu Val Asn Asn Asn Gly Thr Val 
                165                 170                 175     

Ile Asp Ala His Val Phe Pro Lys Asn Ser Tyr Asn Lys Pro Val Val 
            180                 185                 190         

Asp Lys Arg Ile Ala Asp Thr Leu Asn Tyr Asn Asp Gln Asn Gly Leu 
        195                 200                 205             

Ser Ile Gly Thr Lys Ile Pro Tyr Val Val Asn Thr Thr Ile Pro Ser 
    210                 215                 220                 

Asn Ala Thr Phe Ala Thr Ser Phe Trp Ser Asp Glu Met Thr Glu Gly 
225                 230                 235                 240 

Leu Thr Tyr Asn Glu Asp Val Thr Ile Thr Leu Asn Asn Val Ala Met 
                245                 250                 255     

Asp Gln Ala Asp Tyr Glu Val Thr Lys Gly Ile Asn Gly Phe Asn Leu 
            260                 265                 270         

Lys Leu Thr Glu Ala Gly Leu Ala Lys Ile Asn Gly Lys Asp Ala Asp 
        275                 280                 285             

Gln Lys Ile Gln Ile Thr Tyr Ser Ala Thr Leu Asn Ser Leu Ala Val 
    290                 295                 300                 

Ala Asp Ile Pro Glu Ser Asn Asp Ile Thr Tyr His Tyr Gly Asn His 
305                 310                 315                 320 

Gln Asp His Gly Asn Thr Pro Lys Pro Thr Lys Pro Asn Asn Gly Gln 
                325                 330                 335     

Ile Thr Val Thr Lys Thr Trp Asp Ser Gln Pro Ala Pro Glu Gly Val 
            340                 345                 350         

Lys Ala Thr Val Gln Leu Val Asn Ala Lys Thr Gly Glu Lys Val Gly 
        355                 360                 365             

Ala Pro Val Glu Leu Ser Glu Asn Asn Trp Thr Tyr Thr Trp Ser Gly 
    370                 375                 380                 

Leu Asp Asn Ser Ile Glu Tyr Lys Val Glu Glu Glu Tyr Asn Gly Tyr 
385                 390                 395                 400 

Ser Ala Glu Tyr Thr Val Glu Ser Lys Gly Lys Leu Gly Val Lys Asn 
                405                 410                 415     

Trp Lys Asp Asn Asn Pro Ala Pro Ile Asn Pro Glu Glu Pro Arg Val 
            420                 425                 430         

Lys Thr Tyr Gly Lys Lys Phe Val Lys Val Asp Gln Lys Asp Thr Arg 
        435                 440                 445             

Leu Glu Asn Ala Gln Phe Val Val Lys Lys Ala Asp Ser Asn Lys Tyr 
    450                 455                 460                 

Ile Ala Phe Lys Ser Thr Ala Gln Gln Ala Ala Asp Glu Lys Ala Ala 
465                 470                 475                 480 

Ala Thr Ala Lys Gln Lys Leu Asp Ala Ala Val Ala Ala Tyr Thr Asn 
                485                 490                 495     

Ala Ala Asp Lys Gln Ala Ala Gln Ala Leu Val Asp Gln Ala Gln Gln 
            500                 505                 510         

Glu Tyr Asn Val Ala Tyr Lys Glu Ala Lys Phe Gly Tyr Val Glu Val 
        515                 520                 525             

Ala Gly Lys Asp Glu Ala Met Val Leu Thr Ser Asn Thr Asp Gly Gln 
    530                 535                 540                 

Phe Gln Ile Ser Gly Leu Ala Ala Gly Thr Tyr Lys Leu Glu Glu Ile 
545                 550                 555                 560 

Lys Ala Pro Glu Gly Phe Ala Lys Ile Asp Asp Val Glu Phe Val Val 
                565                 570                 575     

Gly Ala Gly Ser Trp Asn Gln Gly Glu Phe Asn Tyr Leu Lys Asp Val 
            580                 585                 590         

Gln Lys Asn Asp Ala Thr Lys Val Val Asn Lys Lys Ile Thr Ile Pro 
        595                 600                 605             

Gln Thr Gly Gly Ile Gly Thr Ile Ile Phe Ala Val Ala Gly Ala Ala 
    610                 615                 620                 

Ile Met Gly Ile Ala Val Tyr Ala Tyr Val Lys Asn Asn Lys Asp Glu 
625                 630                 635                 640 

Asp Gln Leu Ala 
                

<210>   322
<211>   654
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   RrgB sequence

<400>   322
Met Lys Ser Ile Asn Lys Phe Leu Thr Met Leu Ala Ala Leu Leu Leu 
1               5                   10                  15      

Thr Ala Ser Ser Leu Phe Ser Ala Ala Thr Val Phe Ala Ala Glu Gln 
            20                  25                  30          

Lys Thr Lys Thr Leu Thr Val His Lys Leu Leu Met Thr Asp Gln Glu 
        35                  40                  45              

Leu Asp Ala Trp Asn Ser Asp Ala Ile Thr Thr Ala Gly Tyr Asp Gly 
    50                  55                  60                  

Ser Gln Asn Phe Glu Gln Phe Lys Gln Leu Gln Gly Val Pro Gln Gly 
65                  70                  75                  80  

Val Thr Glu Ile Ser Gly Val Ala Phe Glu Leu Gln Ser Tyr Thr Gly 
                85                  90                  95      

Pro Gln Gly Lys Glu Gln Glu Asn Leu Thr Asn Asp Ala Val Trp Thr 
            100                 105                 110         

Ala Val Asn Lys Gly Val Thr Thr Glu Thr Gly Val Lys Phe Asp Thr 
        115                 120                 125             

Glu Val Leu Gln Gly Thr Tyr Arg Leu Val Glu Val Arg Lys Glu Ser 
    130                 135                 140                 

Thr Tyr Val Gly Pro Asn Gly Lys Val Leu Thr Gly Met Lys Ala Val 
145                 150                 155                 160 

Pro Ala Leu Ile Ile Leu Pro Leu Val Asn Gln Asn Gly Val Val Glu 
                165                 170                 175     

Asn Ala His Val Tyr Pro Lys Asn Ser Glu Asp Lys Pro Thr Ala Thr 
            180                 185                 190         

Lys Thr Phe Asp Thr Ala Ala Gly Phe Val Asp Pro Gly Glu Lys Gly 
        195                 200                 205             

Leu Ala Ile Gly Thr Lys Val Pro Tyr Ile Val Thr Thr Thr Ile Pro 
    210                 215                 220                 

Lys Asn Ser Thr Leu Ala Thr Ala Phe Trp Ser Asp Glu Met Thr Glu 
225                 230                 235                 240 

Gly Leu Asp Tyr Asn Gly Asp Val Val Val Asn Tyr Asn Gly Gln Pro 
                245                 250                 255     

Leu Asp Asn Ser His Tyr Thr Leu Glu Ala Gly His Asn Gly Phe Ile 
            260                 265                 270         

Leu Lys Leu Asn Glu Lys Gly Leu Glu Ala Ile Asn Gly Lys Asp Ala 
        275                 280                 285             

Glu Ala Thr Ile Thr Leu Lys Tyr Thr Ala Thr Leu Asn Ala Leu Ala 
    290                 295                 300                 

Val Ala Asp Val Pro Glu Ala Asn Asp Val Thr Phe His Tyr Gly Asn 
305                 310                 315                 320 

Asn Pro Gly His Gly Asn Thr Pro Lys Pro Asn Lys Pro Lys Asn Gly 
                325                 330                 335     

Glu Leu Thr Ile Thr Lys Thr Trp Ala Asp Ala Lys Asp Ala Pro Ile 
            340                 345                 350         

Ala Gly Val Glu Val Thr Phe Asp Leu Val Asn Ala Gln Thr Gly Glu 
        355                 360                 365             

Val Val Lys Val Pro Gly His Glu Thr Gly Ile Val Leu Asn Gln Thr 
    370                 375                 380                 

Asn Asn Trp Thr Phe Thr Ala Thr Gly Leu Asp Asn Asn Thr Glu Tyr 
385                 390                 395                 400 

Lys Phe Val Glu Arg Thr Ile Lys Gly Tyr Ser Ala Asp Tyr Gln Thr 
                405                 410                 415     

Ile Thr Glu Thr Gly Lys Ile Ala Val Lys Asn Trp Lys Asp Glu Asn 
            420                 425                 430         

Pro Glu Pro Ile Asn Pro Glu Glu Pro Arg Val Lys Thr Tyr Gly Lys 
        435                 440                 445             

Lys Phe Val Lys Val Asp Gln Lys Asp Glu Arg Leu Lys Glu Ala Gln 
    450                 455                 460                 

Phe Val Val Lys Asn Glu Gln Gly Lys Tyr Leu Ala Leu Lys Ser Ala 
465                 470                 475                 480 

Ala Gln Gln Ala Val Asn Glu Lys Ala Ala Ala Glu Ala Lys Gln Ala 
                485                 490                 495     

Leu Asp Ala Ala Ile Ala Ala Tyr Thr Asn Ala Ala Asp Lys Asn Ala 
            500                 505                 510         

Ala Gln Ala Val Val Asp Ala Ala Gln Lys Thr Tyr Asn Asp Asn Tyr 
        515                 520                 525             

Arg Ala Ala Arg Phe Gly Tyr Val Glu Val Glu Arg Lys Glu Asp Ala 
    530                 535                 540                 

Leu Val Leu Thr Ser Asn Thr Asp Gly Gln Phe Gln Ile Ser Gly Leu 
545                 550                 555                 560 

Ala Ala Gly Ser Tyr Thr Leu Glu Glu Thr Lys Ala Pro Glu Gly Phe 
                565                 570                 575     

Ala Lys Leu Gly Asp Val Lys Phe Glu Val Gly Ala Gly Ser Trp Asn 
            580                 585                 590         

Gln Gly Asp Phe Asn Tyr Leu Lys Asp Val Gln Lys Asn Asp Ala Thr 
        595                 600                 605             

Lys Val Val Asn Lys Lys Ile Thr Ile Pro Gln Thr Gly Gly Ile Gly 
    610                 615                 620                 

Thr Ile Ile Phe Ala Val Ala Gly Ala Val Ile Met Gly Ile Ala Val 
625                 630                 635                 640 

Tyr Ala Tyr Val Lys Asn Asn Lys Asp Glu Asp Gln Leu Ala 
                645                 650                 

<210>   323
<211>   665
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   RrgB sequence

<400>   323
Met Lys Ser Ile Asn Lys Phe Leu Thr Met Leu Ala Ala Leu Leu Leu 
1               5                   10                  15      

Thr Ala Ser Ser Leu Phe Ser Ala Ala Thr Val Phe Ala Ala Gly Thr 
            20                  25                  30          

Thr Thr Thr Ser Val Thr Val His Lys Leu Leu Ala Thr Asp Gly Asp 
        35                  40                  45              

Met Asp Lys Ile Ala Asn Glu Leu Glu Thr Gly Asn Tyr Ala Gly Asn 
    50                  55                  60                  

Lys Val Gly Val Leu Pro Ala Asn Ala Lys Glu Ile Ala Gly Val Met 
65                  70                  75                  80  

Phe Val Trp Thr Asn Thr Asn Asn Glu Ile Ile Asp Glu Asn Gly Gln 
                85                  90                  95      

Thr Leu Gly Val Asn Ile Asp Pro Gln Thr Phe Lys Leu Ser Gly Ala 
            100                 105                 110         

Met Pro Ala Thr Ala Met Lys Lys Leu Thr Glu Ala Glu Gly Ala Lys 
        115                 120                 125             

Phe Asn Thr Ala Asn Leu Pro Ala Ala Lys Tyr Lys Ile Tyr Glu Ile 
    130                 135                 140                 

His Ser Leu Ser Thr Tyr Val Gly Glu Asp Gly Ala Thr Leu Thr Gly 
145                 150                 155                 160 

Ser Lys Ala Val Pro Ile Glu Ile Glu Leu Pro Leu Asn Asp Val Val 
                165                 170                 175     

Asp Ala His Val Tyr Pro Lys Asn Thr Glu Ala Lys Pro Lys Ile Asp 
            180                 185                 190         

Lys Asp Phe Lys Gly Lys Ala Asn Pro Asp Thr Pro Arg Val Asp Lys 
        195                 200                 205             

Asp Thr Pro Val Asn His Gln Val Gly Asp Val Val Glu Tyr Glu Ile 
    210                 215                 220                 

Val Thr Lys Ile Pro Ala Leu Ala Asn Tyr Ala Thr Ala Asn Trp Ser 
225                 230                 235                 240 

Asp Arg Met Thr Glu Gly Leu Ala Phe Asn Lys Gly Thr Val Lys Val 
                245                 250                 255     

Thr Val Asp Asp Val Ala Leu Glu Ala Gly Asp Tyr Ala Leu Thr Glu 
            260                 265                 270         

Val Ala Thr Gly Phe Asp Leu Lys Leu Thr Asp Ala Gly Leu Ala Lys 
        275                 280                 285             

Val Asn Asp Gln Asn Ala Glu Lys Thr Val Lys Ile Thr Tyr Ser Ala 
    290                 295                 300                 

Thr Leu Asn Asp Lys Ala Ile Val Glu Val Pro Glu Ser Asn Asp Val 
305                 310                 315                 320 

Thr Phe Asn Tyr Gly Asn Asn Pro Asp His Gly Asn Thr Pro Lys Pro 
                325                 330                 335     

Asn Lys Pro Asn Glu Asn Gly Asp Leu Thr Leu Thr Lys Thr Trp Val 
            340                 345                 350         

Asp Ala Thr Gly Ala Pro Ile Pro Ala Gly Ala Glu Ala Thr Phe Asp 
        355                 360                 365             

Leu Val Asn Ala Gln Thr Gly Lys Val Val Gln Thr Val Thr Leu Thr 
    370                 375                 380                 

Thr Asp Lys Asn Thr Val Thr Val Asn Gly Leu Asp Lys Asn Thr Glu 
385                 390                 395                 400 

Tyr Lys Phe Val Glu Arg Ser Ile Lys Gly Tyr Ser Ala Asp Tyr Gln 
                405                 410                 415     

Glu Ile Thr Thr Ala Gly Glu Ile Ala Val Lys Asn Trp Lys Asp Glu 
            420                 425                 430         

Asn Pro Lys Pro Leu Asp Pro Thr Glu Pro Lys Val Val Thr Tyr Gly 
        435                 440                 445             

Lys Lys Phe Val Lys Val Asn Asp Lys Asp Asn Arg Leu Ala Gly Ala 
    450                 455                 460                 

Glu Phe Val Ile Ala Asn Ala Asp Asn Ala Gly Gln Tyr Leu Ala Arg 
465                 470                 475                 480 

Lys Ala Asp Lys Val Ser Gln Glu Glu Lys Gln Leu Val Val Thr Thr 
                485                 490                 495     

Lys Asp Ala Leu Asp Arg Ala Val Ala Ala Tyr Asn Ala Leu Thr Ala 
            500                 505                 510         

Gln Gln Gln Thr Gln Gln Glu Lys Glu Lys Val Asp Lys Ala Gln Ala 
        515                 520                 525             

Ala Tyr Asn Ala Ala Val Ile Ala Ala Asn Asn Ala Phe Glu Trp Val 
    530                 535                 540                 

Ala Asp Lys Asp Asn Glu Asn Val Val Lys Leu Val Ser Asp Ala Gln 
545                 550                 555                 560 

Gly Arg Phe Glu Ile Thr Gly Leu Leu Ala Gly Thr Tyr Tyr Leu Glu 
                565                 570                 575     

Glu Thr Lys Gln Pro Ala Gly Tyr Ala Leu Leu Thr Ser Arg Gln Lys 
            580                 585                 590         

Phe Glu Val Thr Ala Thr Ser Tyr Ser Ala Thr Gly Gln Gly Ile Glu 
        595                 600                 605             

Tyr Thr Ala Gly Ser Gly Lys Asp Asp Ala Thr Lys Val Val Asn Lys 
    610                 615                 620                 

Lys Ile Met Ile Pro Gln Pro Gly Gly Ile Gly Thr Ile Ile Phe Ala 
625                 630                 635                 640 

Val Ala Gly Ala Val Ile Met Gly Ile Ala Val Tyr Ala Tyr Val Lys 
                645                 650                 655     

Asn Asn Lys Asp Glu Asp Gln Leu Ala 
            660                 665 

<210>   324
<211>   665
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   RrgB sequence

<400>   324
Met Lys Ser Ile Asn Lys Phe Leu Thr Met Leu Ala Ala Leu Leu Leu 
1               5                   10                  15      

Thr Ala Ser Ser Leu Phe Ser Ala Ala Thr Val Phe Ala Ala Gly Thr 
            20                  25                  30          

Thr Thr Thr Ser Val Thr Val His Lys Leu Leu Ala Thr Asp Gly Asp 
        35                  40                  45              

Met Asp Lys Ile Ala Asn Glu Leu Glu Thr Gly Asn Tyr Ala Gly Asn 
    50                  55                  60                  

Lys Val Gly Val Leu Pro Ala Asn Ala Lys Glu Ile Ala Gly Val Met 
65                  70                  75                  80  

Phe Val Trp Thr Asn Thr Asn Asn Glu Ile Ile Asp Glu Asn Gly Gln 
                85                  90                  95      

Thr Leu Gly Val Asn Ile Asp Pro Gln Thr Phe Lys Leu Ser Gly Ala 
            100                 105                 110         

Met Pro Ala Thr Ala Met Lys Lys Leu Thr Glu Ala Glu Gly Ala Lys 
        115                 120                 125             

Phe Asn Thr Ala Asn Leu Pro Ala Ala Lys Tyr Lys Ile Tyr Glu Ile 
    130                 135                 140                 

His Ser Leu Ser Thr Tyr Val Gly Glu Asp Gly Ala Thr Leu Thr Gly 
145                 150                 155                 160 

Ser Lys Ala Val Pro Ile Glu Ile Glu Leu Pro Leu Asn Asp Val Val 
                165                 170                 175     

Asp Ala His Val Tyr Pro Lys Asn Thr Glu Ala Lys Pro Lys Ile Asp 
            180                 185                 190         

Lys Asp Phe Lys Gly Lys Ala Asn Pro Asp Thr Pro Arg Val Asp Lys 
        195                 200                 205             

Asp Thr Pro Val Asn His Gln Val Gly Asp Val Val Glu Tyr Glu Ile 
    210                 215                 220                 

Val Thr Lys Ile Pro Ala Leu Ala Asn Tyr Ala Thr Ala Asn Trp Ser 
225                 230                 235                 240 

Asp Arg Met Thr Glu Gly Leu Ala Phe Asn Lys Gly Thr Val Lys Val 
                245                 250                 255     

Thr Val Asp Asp Val Ala Leu Glu Ala Gly Asp Tyr Ala Leu Thr Glu 
            260                 265                 270         

Val Ala Thr Gly Phe Asp Leu Lys Leu Thr Asp Ala Gly Leu Ala Lys 
        275                 280                 285             

Val Asn Asp Gln Asn Ala Glu Lys Thr Val Lys Ile Thr Tyr Ser Ala 
    290                 295                 300                 

Thr Leu Asn Asp Lys Ala Ile Val Glu Val Pro Glu Ser Asn Asp Val 
305                 310                 315                 320 

Thr Phe Asn Tyr Gly Asn Asn Pro Asp His Gly Asn Thr Pro Lys Pro 
                325                 330                 335     

Asn Lys Pro Asn Glu Asn Gly Asp Leu Thr Leu Thr Lys Thr Trp Val 
            340                 345                 350         

Asp Asp Thr Gly Ala Ala Ile Pro Ala Gly Asp Glu Ala Thr Phe Asp 
        355                 360                 365             

Leu Val Asn Ala Gln Thr Gly Lys Val Val Gln Leu Val Thr Ser Ser 
    370                 375                 380                 

Thr Asp Lys Asn Thr Val Thr Val Thr Gly Leu Asp Lys Asn Thr Glu 
385                 390                 395                 400 

Tyr Lys Phe Val Glu Arg Ser Ile Lys Gly Tyr Ser Ala Asp Tyr Gln 
                405                 410                 415     

Glu Ile Thr Thr Ala Gly Glu Ile Ala Val Lys Asn Trp Lys Asp Glu 
            420                 425                 430         

Asn Pro Lys Pro Leu Asp Pro Thr Glu Pro Lys Val Val Thr Tyr Gly 
        435                 440                 445             

Lys Lys Phe Val Lys Val Asn Asp Lys Asp Asn Arg Leu Ala Gly Ala 
    450                 455                 460                 

Glu Phe Val Ile Ala Asn Ala Asp Asn Ala Gly Gln Tyr Leu Ala Arg 
465                 470                 475                 480 

Lys Ala Asp Lys Val Ser Gln Glu Glu Lys Gln Leu Val Val Thr Thr 
                485                 490                 495     

Lys Asp Ala Leu Asp Arg Ala Val Ala Ala Tyr Asn Ala Leu Thr Ala 
            500                 505                 510         

Gln Gln Gln Thr Gln Gln Glu Lys Glu Lys Val Asp Lys Ala Gln Ala 
        515                 520                 525             

Ala Tyr Asn Ala Ala Val Ile Ala Ala Asn Asn Ala Phe Glu Trp Val 
    530                 535                 540                 

Ala Asp Lys Asp Asn Glu Asn Val Val Lys Leu Val Ser Asp Ala Gln 
545                 550                 555                 560 

Gly Arg Phe Glu Ile Thr Gly Leu Leu Ala Gly Thr Tyr Tyr Leu Glu 
                565                 570                 575     

Glu Thr Lys Gln Pro Ala Gly Tyr Ala Leu Leu Thr Ser Arg Gln Lys 
            580                 585                 590         

Phe Glu Val Thr Ala Thr Ser Tyr Ser Ala Thr Gly Gln Gly Ile Glu 
        595                 600                 605             

Tyr Thr Ala Gly Ser Gly Lys Asp Asp Ala Thr Lys Val Val Asn Lys 
    610                 615                 620                 

Lys Ile Thr Ile Pro Gln Thr Gly Gly Ile Gly Thr Ile Ile Phe Ala 
625                 630                 635                 640 

Val Ala Gly Ala Val Ile Met Gly Ile Ala Val Tyr Ala Tyr Val Lys 
                645                 650                 655     

Asn Asn Lys Asp Glu Asp His Leu Ala 
            660                 665 

<210>   325
<211>   644
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   RrgB sequence

<400>   325
Met Lys Ser Ile Asn Lys Phe Leu Thr Met Leu Ala Ala Leu Leu Leu 
1               5                   10                  15      

Thr Ala Ser Ser Leu Phe Ser Ala Ala Thr Val Phe Ala Ala Asp Asn 
            20                  25                  30          

Val Ser Thr Ala Pro Asp Ala Val Thr Lys Thr Leu Thr Ile His Lys 
        35                  40                  45              

Leu Leu Leu Ser Glu Asp Asp Leu Lys Thr Trp Asp Thr Asn Gly Pro 
    50                  55                  60                  

Lys Gly Tyr Asp Gly Thr Gln Ser Ser Leu Lys Asp Leu Thr Gly Val 
65                  70                  75                  80  

Val Ala Glu Glu Ile Pro Asn Val Tyr Phe Glu Leu Gln Lys Tyr Asn 
                85                  90                  95      

Leu Thr Asp Gly Lys Glu Lys Glu Asn Leu Lys Asp Asp Ser Lys Trp 
            100                 105                 110         

Thr Thr Val His Gly Gly Leu Thr Thr Lys Asp Gly Leu Lys Ile Glu 
        115                 120                 125             

Thr Ser Thr Leu Lys Gly Val Tyr Arg Ile Arg Glu Asp Arg Thr Lys 
    130                 135                 140                 

Thr Thr Tyr Val Gly Pro Asn Gly Gln Val Leu Thr Gly Ser Lys Ala 
145                 150                 155                 160 

Val Pro Ala Leu Val Thr Leu Pro Leu Val Asn Asn Asn Gly Thr Val 
                165                 170                 175     

Ile Asp Ala His Val Phe Pro Lys Asn Ser Tyr Asn Lys Pro Val Val 
            180                 185                 190         

Asp Lys Arg Ile Ala Asp Thr Leu Asn Tyr Asn Asp Gln Asn Gly Leu 
        195                 200                 205             

Ser Ile Gly Thr Lys Ile Pro Tyr Val Val Asn Thr Thr Ile Pro Ser 
    210                 215                 220                 

Asn Ala Thr Phe Ala Thr Ser Phe Trp Ser Asp Glu Met Thr Glu Gly 
225                 230                 235                 240 

Leu Thr Tyr Asn Glu Asp Val Thr Ile Thr Leu Asn Asn Val Ala Met 
                245                 250                 255     

Asp Gln Ala Asp Tyr Glu Val Thr Lys Gly Ile Asn Gly Phe Asn Leu 
            260                 265                 270         

Lys Leu Thr Glu Ala Gly Leu Ala Lys Ile Asn Gly Lys Asp Ala Asp 
        275                 280                 285             

Gln Lys Ile Gln Ile Thr Tyr Ser Ala Thr Leu Asn Ser Leu Ala Val 
    290                 295                 300                 

Ala Asp Ile Pro Glu Ser Asn Asp Ile Thr Tyr His Tyr Gly Asn His 
305                 310                 315                 320 

Gln Asp His Gly Asn Thr Pro Lys Pro Thr Lys Pro Asn Asn Gly Gln 
                325                 330                 335     

Ile Thr Val Thr Lys Thr Trp Asp Ser Gln Pro Ala Pro Glu Gly Val 
            340                 345                 350         

Lys Ala Thr Val Gln Leu Val Asn Ala Lys Thr Gly Glu Lys Val Gly 
        355                 360                 365             

Ala Pro Val Glu Leu Ser Glu Asn Asn Trp Thr Tyr Thr Trp Ser Gly 
    370                 375                 380                 

Leu Asp Asn Ser Ile Glu Tyr Lys Val Glu Glu Glu Tyr Asn Gly Tyr 
385                 390                 395                 400 

Ser Ala Glu Tyr Thr Val Glu Ser Lys Gly Lys Leu Gly Val Lys Asn 
                405                 410                 415     

Trp Lys Asp Asn Asn Pro Ala Pro Ile Asn Leu Glu Glu Pro Arg Val 
            420                 425                 430         

Lys Thr Tyr Gly Lys Lys Phe Val Lys Val Asp Gln Lys Asp Thr Arg 
        435                 440                 445             

Leu Glu Asn Ala Gln Phe Val Val Lys Lys Ala Asp Ser Asn Lys Tyr 
    450                 455                 460                 

Ile Ala Phe Lys Ser Thr Ala Gln Gln Ala Ala Asp Glu Lys Ala Ala 
465                 470                 475                 480 

Ala Thr Ala Lys Gln Lys Leu Asp Ala Ala Val Ala Ala Tyr Thr Asn 
                485                 490                 495     

Ala Ala Asp Lys Gln Ala Ala Gln Ala Leu Val Asp Gln Ala Gln Gln 
            500                 505                 510         

Glu Tyr Asn Val Ala Tyr Lys Glu Ala Lys Phe Gly Tyr Val Glu Val 
        515                 520                 525             

Ala Gly Lys Asp Glu Ala Met Val Leu Thr Ser Asn Thr Asp Gly Gln 
    530                 535                 540                 

Phe Gln Ile Ser Gly Leu Ala Ala Gly Thr Tyr Lys Leu Glu Glu Ile 
545                 550                 555                 560 

Lys Ala Pro Glu Gly Phe Ala Lys Ile Asp Asp Val Glu Phe Val Val 
                565                 570                 575     

Gly Ala Gly Ser Trp Asn Gln Gly Glu Phe Asn Tyr Leu Lys Asp Val 
            580                 585                 590         

Gln Lys Asn Asp Ala Thr Lys Val Val Asn Lys Lys Ile Thr Ile Pro 
        595                 600                 605             

Gln Thr Gly Gly Ile Gly Thr Ile Ile Phe Ala Val Ala Gly Ala Val 
    610                 615                 620                 

Ile Met Gly Ile Ala Val Tyr Ala Tyr Val Lys Asn Asn Lys Asp Glu 
625                 630                 635                 640 

Asp Gln Leu Ala 
                

<210>   326
<211>   644
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   RrgB sequence

<400>   326
Met Lys Ser Ile Asn Lys Phe Leu Thr Met Leu Ala Ala Leu Leu Leu 
1               5                   10                  15      

Thr Ala Ser Ser Leu Phe Ser Ala Ala Thr Val Phe Ala Ala Asp Asn 
            20                  25                  30          

Val Ser Thr Ala Pro Asp Ala Val Thr Lys Thr Leu Thr Ile His Lys 
        35                  40                  45              

Leu Leu Leu Ser Glu Asp Asp Leu Lys Thr Trp Asp Thr Asn Gly Pro 
    50                  55                  60                  

Lys Gly Tyr Asp Gly Thr Gln Ser Ser Leu Lys Asp Leu Thr Gly Val 
65                  70                  75                  80  

Val Ala Glu Glu Ile Pro Asn Val Tyr Phe Glu Leu Gln Lys Tyr Asn 
                85                  90                  95      

Leu Thr Asp Gly Lys Glu Lys Glu Asn Leu Lys Asp Asp Ser Lys Trp 
            100                 105                 110         

Thr Thr Val His Gly Gly Leu Thr Thr Lys Asp Gly Leu Lys Ile Glu 
        115                 120                 125             

Thr Ser Thr Leu Lys Gly Val Tyr Arg Ile Arg Glu Asp Arg Thr Lys 
    130                 135                 140                 

Thr Thr Tyr Val Gly Pro Asn Gly Gln Val Leu Thr Gly Ser Lys Ala 
145                 150                 155                 160 

Val Pro Ala Leu Val Thr Leu Pro Leu Val Asn Asn Asn Gly Thr Val 
                165                 170                 175     

Ile Asp Ala His Val Phe Pro Lys Asn Ser Tyr Asn Lys Pro Val Val 
            180                 185                 190         

Asp Lys Arg Ile Ala Asp Thr Leu Asn Tyr Asn Asp Gln Asn Gly Leu 
        195                 200                 205             

Ser Ile Gly Thr Lys Ile Pro Tyr Val Val Asn Thr Thr Ile Pro Ser 
    210                 215                 220                 

Asn Ala Thr Phe Ala Thr Ser Phe Trp Ser Asp Glu Met Thr Glu Gly 
225                 230                 235                 240 

Leu Thr Tyr Asn Glu Asp Val Thr Ile Thr Leu Asn Asn Val Ala Met 
                245                 250                 255     

Asp Gln Ala Asp Tyr Glu Val Thr Lys Gly Asn Asn Gly Phe Asn Leu 
            260                 265                 270         

Lys Leu Thr Glu Ala Gly Leu Ala Lys Ile Asn Gly Lys Asp Ala Asp 
        275                 280                 285             

Gln Lys Ile Gln Ile Thr Tyr Ser Ala Thr Leu Asn Ser Leu Ala Val 
    290                 295                 300                 

Ala Asp Ile Pro Glu Ser Asn Asp Ile Thr Tyr His Tyr Gly Asn His 
305                 310                 315                 320 

Gln Asp His Gly Asn Thr Pro Lys Pro Thr Lys Pro Asn Asn Gly Gln 
                325                 330                 335     

Ile Thr Val Thr Lys Thr Trp Asp Ser Gln Pro Ala Pro Glu Gly Val 
            340                 345                 350         

Lys Ala Thr Val Gln Leu Val Asn Ala Lys Thr Gly Glu Lys Val Gly 
        355                 360                 365             

Ala Pro Val Glu Leu Ser Glu Asn Asn Trp Thr Tyr Thr Trp Ser Gly 
    370                 375                 380                 

Leu Asp Asn Ser Ile Glu Tyr Lys Val Glu Glu Glu Tyr Asn Gly Tyr 
385                 390                 395                 400 

Ser Ala Glu Tyr Thr Val Glu Ser Lys Gly Lys Leu Gly Val Lys Asn 
                405                 410                 415     

Trp Lys Asp Asn Asn Pro Ala Pro Ile Asn Pro Glu Glu Pro Arg Val 
            420                 425                 430         

Lys Thr Tyr Gly Lys Lys Phe Val Lys Val Asp Gln Lys Asp Thr Arg 
        435                 440                 445             

Leu Glu Asn Ala Gln Phe Val Val Lys Lys Ala Asp Ser Asn Lys Tyr 
    450                 455                 460                 

Ile Ala Phe Lys Ser Thr Ala Gln Gln Ala Ala Asp Glu Lys Ala Ala 
465                 470                 475                 480 

Ala Thr Ala Lys Gln Lys Leu Asp Ala Ala Val Ala Ala Tyr Thr Asn 
                485                 490                 495     

Ala Ala Asp Lys Gln Asp Ala Gln Ala Leu Val Asp Gln Ala Gln Gln 
            500                 505                 510         

Glu Tyr Asn Val Ala Tyr Lys Glu Ala Lys Phe Gly Tyr Val Glu Val 
        515                 520                 525             

Ala Gly Lys Asp Glu Ala Met Val Leu Thr Ser Asn Thr Asp Gly Gln 
    530                 535                 540                 

Phe Gln Ile Ser Gly Leu Ala Ala Gly Thr Tyr Lys Leu Glu Glu Ile 
545                 550                 555                 560 

Lys Ala Pro Glu Gly Phe Ala Lys Ile Asp Asp Val Glu Phe Val Val 
                565                 570                 575     

Gly Ala Gly Ser Trp Asn Gln Gly Glu Phe Asn Tyr Leu Lys Asp Val 
            580                 585                 590         

Gln Lys Asn Asp Ala Thr Lys Val Val Asn Lys Lys Ile Thr Ile Pro 
        595                 600                 605             

Gln Thr Gly Gly Ile Gly Thr Ile Ile Phe Ala Val Ala Gly Ala Ala 
    610                 615                 620                 

Ile Met Gly Ile Ala Val Tyr Ala Tyr Val Lys Asn Asn Lys Asp Glu 
625                 630                 635                 640 

Asp Gln Leu Ala 
                

<210>   327
<211>   654
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   RrgB sequence

<400>   327
Met Lys Ser Ile Asn Lys Phe Leu Thr Ile Leu Ala Ala Leu Leu Leu 
1               5                   10                  15      

Thr Val Ser Ser Leu Phe Ser Ala Ala Thr Val Phe Ala Ala Glu Gln 
            20                  25                  30          

Lys Thr Lys Thr Leu Thr Val His Lys Leu Leu Met Thr Asp Gln Glu 
        35                  40                  45              

Leu Asp Ala Trp Asn Ser Asp Ala Ile Thr Thr Ala Gly Tyr Asp Gly 
    50                  55                  60                  

Ser Gln Asn Phe Glu Gln Phe Lys Gln Leu Gln Gly Val Pro Gln Gly 
65                  70                  75                  80  

Val Thr Glu Ile Ser Gly Val Ala Phe Glu Leu Gln Ser Tyr Thr Gly 
                85                  90                  95      

Pro Gln Gly Lys Glu Gln Glu Asn Leu Thr Asn Asp Ala Val Trp Thr 
            100                 105                 110         

Ala Val Asn Lys Gly Val Thr Thr Glu Thr Gly Val Lys Phe Asp Thr 
        115                 120                 125             

Glu Val Leu Gln Gly Thr Tyr Arg Leu Val Glu Val Arg Lys Glu Ser 
    130                 135                 140                 

Thr Tyr Val Gly Pro Asn Gly Lys Val Leu Thr Gly Met Lys Ala Val 
145                 150                 155                 160 

Pro Ala Leu Ile Ile Leu Pro Leu Val Asn Gln Asn Gly Val Val Glu 
                165                 170                 175     

Asn Ala His Val Tyr Pro Lys Asn Ser Glu Asp Lys Pro Thr Ala Thr 
            180                 185                 190         

Lys Thr Phe Asp Thr Ala Ala Gly Phe Val Asp Pro Gly Glu Lys Gly 
        195                 200                 205             

Leu Ala Ile Gly Thr Lys Val Pro Tyr Ile Val Thr Thr Thr Ile Pro 
    210                 215                 220                 

Lys Asn Ser Thr Leu Ala Thr Ala Phe Trp Ser Asp Glu Met Thr Glu 
225                 230                 235                 240 

Gly Leu Asp Tyr Asn Gly Asp Val Val Val Asn Tyr Asn Gly Gln Pro 
                245                 250                 255     

Leu Asp Asn Ser His Tyr Thr Leu Glu Ala Gly His Asn Gly Phe Ile 
            260                 265                 270         

Leu Lys Leu Asn Glu Lys Gly Leu Glu Ala Ile Asn Gly Lys Asp Ala 
        275                 280                 285             

Glu Ala Thr Ile Ala Leu Lys Tyr Thr Ala Thr Leu Asn Ala Leu Ala 
    290                 295                 300                 

Val Ala Asp Val Pro Glu Ala Asn Asp Val Thr Phe His Tyr Gly Asn 
305                 310                 315                 320 

Asn Pro Gly His Gly Asn Thr Pro Lys Pro Asn Lys Pro Lys Asn Gly 
                325                 330                 335     

Glu Leu Thr Ile Thr Lys Thr Trp Ala Asp Ala Lys Asp Ala Pro Ile 
            340                 345                 350         

Ala Gly Val Glu Val Thr Phe Asp Leu Val Asn Ala Gln Thr Gly Glu 
        355                 360                 365             

Val Val Lys Val Pro Gly His Glu Thr Gly Ile Val Leu Asn Gln Thr 
    370                 375                 380                 

Asn Asn Trp Thr Phe Thr Ala Thr Gly Leu Asp Asn Asn Thr Glu Tyr 
385                 390                 395                 400 

Lys Phe Val Glu Arg Thr Ile Lys Gly Tyr Ser Ala Asp Tyr Gln Thr 
                405                 410                 415     

Ile Thr Glu Thr Gly Lys Ile Ala Val Lys Asn Trp Lys Asp Glu Asn 
            420                 425                 430         

Pro Glu Pro Ile Asn Pro Glu Glu Pro Arg Val Lys Thr Tyr Gly Lys 
        435                 440                 445             

Lys Phe Val Lys Val Asp Gln Lys Asp Glu Arg Leu Lys Glu Ala Gln 
    450                 455                 460                 

Phe Val Val Lys Asn Glu Gln Gly Lys Tyr Leu Ala Leu Lys Ser Ala 
465                 470                 475                 480 

Ala Gln Gln Ala Val Asn Glu Lys Ala Ala Ala Glu Ala Lys Gln Ala 
                485                 490                 495     

Leu Asp Ala Ala Ile Ala Ala Tyr Thr Asn Ala Ala Asp Lys Asn Ala 
            500                 505                 510         

Ala Gln Ala Val Val Asp Ala Ala Gln Lys Thr Tyr Asn Asp Asn Tyr 
        515                 520                 525             

Arg Ala Ala Arg Phe Gly Tyr Val Glu Val Glu Arg Lys Glu Asp Ala 
    530                 535                 540                 

Leu Val Leu Thr Ser Asn Thr Asp Gly Gln Phe Gln Ile Ser Gly Leu 
545                 550                 555                 560 

Ala Ala Gly Ser Tyr Thr Leu Glu Glu Thr Lys Ala Pro Glu Gly Phe 
                565                 570                 575     

Ala Lys Leu Gly Asp Val Lys Phe Glu Val Gly Ala Gly Ser Trp Asn 
            580                 585                 590         

Gln Gly Asp Phe Asn Tyr Leu Lys Asp Val Gln Lys Asn Asp Ala Thr 
        595                 600                 605             

Lys Val Val Asn Lys Lys Ile Thr Ile Pro Gln Thr Gly Gly Ile Gly 
    610                 615                 620                 

Thr Ile Ile Phe Ala Val Ala Gly Ala Val Ile Met Gly Ile Ala Val 
625                 630                 635                 640 

Tyr Ala Tyr Val Lys Asn Asn Lys Asp Glu Asp Gln Leu Ala 
                645                 650                 

<210>   328
<211>   654
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   RrgB sequence

<400>   328
Met Lys Ser Ile Asn Lys Phe Leu Thr Ile Leu Ala Ala Leu Leu Leu 
1               5                   10                  15      

Thr Val Ser Ser Leu Phe Ser Ala Ala Thr Val Phe Ala Ala Glu Gln 
            20                  25                  30          

Lys Thr Lys Thr Leu Thr Val His Lys Leu Leu Met Thr Asp Gln Glu 
        35                  40                  45              

Leu Asp Ala Trp Asn Ser Asp Ala Ile Thr Thr Ala Gly Tyr Asp Gly 
    50                  55                  60                  

Ser Gln Asn Phe Glu Gln Phe Lys Gln Leu Gln Gly Val Pro Gln Gly 
65                  70                  75                  80  

Val Thr Glu Ile Ser Gly Val Ala Phe Glu Leu Gln Ser Tyr Thr Gly 
                85                  90                  95      

Pro Gln Gly Lys Glu Gln Glu Asn Leu Thr Asn Asp Ala Val Trp Thr 
            100                 105                 110         

Ala Val Asn Lys Gly Val Thr Thr Glu Thr Gly Val Lys Phe Asp Thr 
        115                 120                 125             

Glu Val Leu Gln Gly Thr Tyr Arg Leu Val Glu Val Arg Lys Glu Ser 
    130                 135                 140                 

Thr Tyr Val Gly Pro Asn Gly Lys Val Leu Thr Gly Met Lys Ala Val 
145                 150                 155                 160 

Pro Ala Leu Ile Ile Leu Pro Leu Val Asn Gln Asn Gly Val Val Glu 
                165                 170                 175     

Asn Ala His Val Tyr Pro Lys Asn Ser Glu Asp Lys Pro Thr Ala Thr 
            180                 185                 190         

Lys Thr Phe Asp Thr Ala Ala Gly Phe Val Asp Pro Gly Glu Lys Gly 
        195                 200                 205             

Leu Ala Ile Gly Thr Lys Val Pro Tyr Ile Val Thr Thr Thr Ile Pro 
    210                 215                 220                 

Lys Asn Ser Thr Leu Ala Thr Ala Phe Trp Ser Asp Glu Met Thr Glu 
225                 230                 235                 240 

Gly Leu Asp Tyr Asn Gly Asp Val Val Val Asn Tyr Asn Gly Gln Pro 
                245                 250                 255     

Leu Asp Asn Ser His Tyr Thr Leu Lys Ala Gly His Asn Gly Phe Ile 
            260                 265                 270         

Leu Lys Leu Asn Glu Lys Gly Leu Glu Ala Ile Asn Gly Lys Asp Ala 
        275                 280                 285             

Glu Ala Thr Ile Thr Leu Lys Tyr Thr Ala Thr Leu Asn Ala Leu Ala 
    290                 295                 300                 

Val Ala Asp Val Pro Lys Ala Asn Asp Val Thr Phe His Tyr Gly Asn 
305                 310                 315                 320 

Asn Pro Gly His Gly Asn Thr Pro Lys Pro Asn Lys Pro Lys Asn Gly 
                325                 330                 335     

Glu Leu Thr Ile Thr Lys Thr Trp Ala Asp Ala Lys Asp Ala Pro Ile 
            340                 345                 350         

Ala Gly Val Glu Val Thr Phe Asp Leu Val Asn Ala Gln Thr Gly Glu 
        355                 360                 365             

Val Val Lys Val Pro Gly His Glu Thr Gly Ile Val Leu Asn Gln Thr 
    370                 375                 380                 

Asn Asn Trp Thr Phe Thr Ala Thr Gly Leu Asp Asn Asn Thr Glu Tyr 
385                 390                 395                 400 

Lys Phe Val Glu Arg Thr Ile Lys Gly Tyr Ser Ala Asp Tyr Gln Thr 
                405                 410                 415     

Ile Thr Glu Thr Gly Lys Ile Ala Val Lys Asn Trp Lys Asp Glu Asn 
            420                 425                 430         

Pro Glu Pro Ile Asn Pro Glu Glu Pro Arg Val Lys Thr Tyr Gly Lys 
        435                 440                 445             

Lys Phe Val Lys Val Asp Gln Lys Asp Glu Arg Leu Lys Glu Ala Gln 
    450                 455                 460                 

Phe Val Val Lys Asn Glu Gln Gly Lys Tyr Leu Ala Leu Lys Ser Ala 
465                 470                 475                 480 

Ala Gln Gln Ala Val Asn Glu Lys Ala Ala Ala Glu Ala Lys Gln Ala 
                485                 490                 495     

Leu Asp Ala Ala Ile Ala Ala Tyr Thr Asn Ala Ala Asp Lys Asn Ala 
            500                 505                 510         

Ala Gln Ala Val Val Asp Ala Ala Gln Lys Thr Tyr Asn Asp Asn Tyr 
        515                 520                 525             

Arg Ala Ala Arg Phe Gly Tyr Val Glu Val Glu Arg Lys Glu Asp Ala 
    530                 535                 540                 

Leu Val Leu Thr Ser Asn Thr Asp Gly Gln Phe Gln Ile Ser Gly Leu 
545                 550                 555                 560 

Ala Ala Gly Ser Tyr Thr Leu Glu Glu Thr Lys Ala Pro Glu Gly Phe 
                565                 570                 575     

Ala Lys Leu Gly Asp Val Lys Phe Glu Val Gly Ala Gly Ser Trp Asn 
            580                 585                 590         

Gln Gly Asp Phe Asn Tyr Leu Lys Asp Val Gln Lys Asn Asp Ala Thr 
        595                 600                 605             

Lys Val Val Asn Lys Lys Ile Thr Ile Pro Gln Thr Gly Gly Ile Gly 
    610                 615                 620                 

Thr Ile Ile Phe Ala Val Ala Gly Ala Val Ile Met Gly Ile Ala Val 
625                 630                 635                 640 

Tyr Ala Tyr Val Lys Asn Asn Lys Asp Glu Asp Gln Leu Ala 
                645                 650                 

<210>   329
<211>   644
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   RrgB sequence

<400>   329
Met Lys Ser Ile Asn Lys Phe Leu Thr Met Leu Ala Ala Leu Leu Leu 
1               5                   10                  15      

Thr Ala Ser Ser Leu Phe Ser Ala Ala Thr Val Phe Ala Ala Asp Asn 
            20                  25                  30          

Val Ser Thr Ala Pro Asp Ala Val Thr Lys Thr Leu Thr Ile His Lys 
        35                  40                  45              

Leu Leu Leu Ser Glu Asp Asp Leu Glu Thr Trp Asp Thr Asn Gly Pro 
    50                  55                  60                  

Lys Gly Tyr Asp Gly Thr Gln Ser Ser Leu Lys Asp Leu Thr Gly Val 
65                  70                  75                  80  

Val Ala Glu Glu Ile Pro Asn Val Tyr Phe Glu Leu Gln Lys Tyr Asn 
                85                  90                  95      

Leu Thr Asp Gly Lys Glu Lys Glu Asn Leu Lys Asp Asp Ser Lys Trp 
            100                 105                 110         

Thr Thr Val His Gly Gly Leu Thr Thr Lys Asp Gly Leu Lys Ile Glu 
        115                 120                 125             

Thr Ser Thr Leu Lys Gly Val Tyr Arg Ile Arg Glu Asp Arg Thr Lys 
    130                 135                 140                 

Thr Thr Tyr Val Gly Pro Asn Gly Gln Val Leu Thr Gly Ser Lys Ala 
145                 150                 155                 160 

Val Pro Ala Leu Val Thr Leu Pro Leu Val Asn Asn Asn Gly Thr Val 
                165                 170                 175     

Ile Asp Ala His Val Phe Pro Lys Asn Ser Tyr Asn Lys Pro Val Val 
            180                 185                 190         

Asp Lys Arg Ile Ala Asp Thr Leu Asn Tyr Asn Asp Gln Asn Gly Leu 
        195                 200                 205             

Ser Ile Gly Thr Lys Ile Pro Tyr Val Val Asn Thr Thr Ile Pro Ser 
    210                 215                 220                 

Asn Ala Thr Phe Ala Thr Ser Phe Trp Ser Asp Glu Met Thr Glu Gly 
225                 230                 235                 240 

Leu Thr Tyr Asn Glu Asp Val Thr Ile Thr Leu Asn Asn Val Ala Met 
                245                 250                 255     

Asp Gln Ala Asp Tyr Glu Val Thr Lys Gly Ile Asn Gly Phe Asn Leu 
            260                 265                 270         

Lys Leu Thr Glu Ala Gly Leu Ala Lys Ile Asn Gly Lys Asp Ala Asp 
        275                 280                 285             

Gln Lys Ile Gln Ile Thr Tyr Ser Ala Thr Leu Asn Ser Leu Ala Val 
    290                 295                 300                 

Ala Asp Ile Pro Glu Ser Asn Asp Ile Thr Tyr His Tyr Gly Asn His 
305                 310                 315                 320 

Gln Asp His Gly Asn Thr Pro Lys Pro Thr Lys Pro Asn Asn Gly Gln 
                325                 330                 335     

Ile Thr Val Thr Lys Thr Trp Asp Ser Gln Pro Ala Pro Glu Gly Val 
            340                 345                 350         

Lys Ala Thr Val Gln Leu Val Asn Ala Lys Thr Gly Glu Lys Val Cys 
        355                 360                 365             

Ala Pro Val Glu Leu Ser Glu Asn Asn Trp Thr Tyr Thr Trp Ser Gly 
    370                 375                 380                 

Leu Asp Asn Ser Ile Glu Tyr Lys Val Glu Glu Glu Tyr Asn Gly Tyr 
385                 390                 395                 400 

Ser Ala Glu Tyr Thr Val Glu Ser Lys Gly Lys Leu Gly Val Lys Asn 
                405                 410                 415     

Trp Lys Asp Asn Asn Pro Ala Pro Ile Asn Pro Glu Glu Pro Arg Val 
            420                 425                 430         

Lys Thr Tyr Gly Lys Lys Phe Val Lys Val Asp Gln Lys Asp Thr Arg 
        435                 440                 445             

Leu Glu Asn Ala Gln Phe Val Val Lys Lys Ala Asp Ser Asn Lys Tyr 
    450                 455                 460                 

Ile Ala Phe Lys Ser Thr Ala Gln Gln Ala Ala Asp Glu Lys Ala Ala 
465                 470                 475                 480 

Ala Thr Ala Lys Gln Lys Leu Asp Ala Ala Val Ala Ala Tyr Thr Asn 
                485                 490                 495     

Ala Ala Asp Lys Gln Ala Ala Gln Ala Leu Val Asp Gln Ala Gln Gln 
            500                 505                 510         

Glu Tyr Asn Val Ala Tyr Lys Glu Ala Lys Phe Gly Tyr Val Glu Val 
        515                 520                 525             

Ala Gly Lys Asp Glu Ala Met Val Leu Thr Ser Asn Thr Asp Gly Gln 
    530                 535                 540                 

Phe Gln Ile Ser Gly Leu Ala Ala Gly Thr Tyr Lys Leu Glu Glu Ile 
545                 550                 555                 560 

Lys Ala Pro Glu Gly Phe Ala Lys Ile Asp Asp Val Glu Phe Val Val 
                565                 570                 575     

Gly Ala Gly Ser Trp Asn Gln Gly Glu Phe Asn Tyr Leu Lys Asp Val 
            580                 585                 590         

Gln Lys Asn Asp Ala Thr Lys Val Val Asn Lys Lys Ile Thr Ile Pro 
        595                 600                 605             

Gln Thr Gly Gly Ile Gly Thr Ile Ile Phe Ala Val Ala Gly Ala Ala 
    610                 615                 620                 

Ile Met Gly Ile Ala Val Tyr Ala Tyr Val Lys Asn Asn Lys Asp Glu 
625                 630                 635                 640 

Asp Gln Leu Ala 
                

<210>   330
<211>   654
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   RrgB sequence

<400>   330
Met Lys Ser Ile Asn Lys Phe Leu Thr Ile Leu Ala Ala Leu Leu Leu 
1               5                   10                  15      

Thr Val Ser Ser Leu Phe Ser Ala Ala Thr Val Phe Ala Ala Glu Gln 
            20                  25                  30          

Lys Thr Lys Thr Leu Thr Val His Lys Leu Leu Met Thr Asp Gln Glu 
        35                  40                  45              

Leu Asp Ala Trp Asn Ser Asp Ala Ile Thr Thr Ala Gly Tyr Asp Gly 
    50                  55                  60                  

Ser Gln Asn Phe Glu Gln Phe Lys Gln Leu Gln Gly Val Pro Gln Gly 
65                  70                  75                  80  

Val Thr Glu Ile Ser Gly Val Ala Phe Glu Leu Gln Ser Tyr Thr Gly 
                85                  90                  95      

Pro Gln Gly Lys Glu Gln Glu Asn Leu Thr Asn Asp Ala Val Trp Thr 
            100                 105                 110         

Ala Val Asn Lys Gly Val Thr Thr Glu Thr Gly Val Lys Phe Asp Thr 
        115                 120                 125             

Glu Val Leu Gln Gly Thr Tyr Arg Leu Val Glu Val Arg Lys Glu Ser 
    130                 135                 140                 

Thr Tyr Val Gly Pro Asn Gly Lys Val Leu Thr Gly Met Lys Ala Val 
145                 150                 155                 160 

Pro Ala Leu Ile Thr Leu Pro Leu Val Asn Gln Asn Gly Val Val Glu 
                165                 170                 175     

Asn Ala His Val Tyr Pro Lys Asn Ser Glu Asp Lys Pro Thr Ala Thr 
            180                 185                 190         

Lys Thr Phe Asp Thr Ala Ala Gly Phe Val Asp Pro Gly Glu Lys Gly 
        195                 200                 205             

Leu Ala Ile Gly Thr Lys Val Pro Tyr Ile Val Thr Thr Thr Ile Pro 
    210                 215                 220                 

Lys Asn Ser Thr Leu Ala Thr Ala Phe Trp Ser Asp Glu Met Thr Glu 
225                 230                 235                 240 

Gly Leu Asp Tyr Asn Gly Asp Val Val Val Asn Tyr Asn Gly Gln Pro 
                245                 250                 255     

Leu Asp Asn Ser His Tyr Thr Leu Glu Ala Gly His Asn Gly Phe Ile 
            260                 265                 270         

Leu Lys Leu Asn Glu Lys Gly Leu Glu Ala Ile Asn Gly Lys Asp Ala 
        275                 280                 285             

Lys Ala Thr Ile Thr Leu Lys Tyr Thr Ala Thr Leu Asn Ala Leu Ala 
    290                 295                 300                 

Val Ala Asp Val Pro Glu Ala Asn Asp Val Thr Phe His Tyr Gly Asn 
305                 310                 315                 320 

Asn Pro Gly His Gly Asn Thr Pro Lys Pro Asn Lys Pro Lys Asn Gly 
                325                 330                 335     

Glu Leu Thr Ile Thr Lys Thr Trp Ala Asp Ala Lys Asp Ala Pro Ile 
            340                 345                 350         

Ala Gly Val Glu Val Thr Phe Asp Leu Val Asn Ala Gln Thr Gly Glu 
        355                 360                 365             

Val Val Lys Val Pro Gly His Glu Thr Gly Ile Val Leu Asn Gln Thr 
    370                 375                 380                 

Asn Asn Trp Thr Phe Thr Ala Thr Gly Leu Asp Asn Asn Thr Glu Tyr 
385                 390                 395                 400 

Lys Phe Val Glu Arg Thr Ile Lys Gly Tyr Ser Ala Asp Tyr Gln Thr 
                405                 410                 415     

Ile Thr Glu Thr Gly Lys Ile Ala Val Lys Asn Trp Lys Asp Glu Asn 
            420                 425                 430         

Pro Glu Pro Ile Asn Pro Glu Glu Pro Arg Val Lys Thr Tyr Gly Lys 
        435                 440                 445             

Lys Phe Val Lys Val Asp Gln Lys Asp Glu Arg Leu Lys Glu Ala Gln 
    450                 455                 460                 

Phe Val Val Lys Asn Glu Gln Gly Lys Tyr Leu Ala Leu Lys Ser Ala 
465                 470                 475                 480 

Ala Gln Gln Ala Val Asn Glu Lys Ala Ala Ala Glu Ala Lys Gln Ala 
                485                 490                 495     

Leu Asp Ala Ala Ile Ala Ala Tyr Thr Asn Ala Ala Asp Lys Asn Ala 
            500                 505                 510         

Ala Gln Ala Val Val Asp Ala Ala Gln Lys Thr Tyr Asn Asp Asn Tyr 
        515                 520                 525             

Arg Ala Ala Arg Phe Gly Tyr Val Glu Val Glu Arg Lys Glu Asp Ala 
    530                 535                 540                 

Leu Val Leu Thr Ser Asn Thr Asp Gly Gln Phe Gln Ile Ser Gly Leu 
545                 550                 555                 560 

Ala Ala Gly Ser Tyr Thr Leu Glu Glu Thr Lys Ala Pro Glu Gly Phe 
                565                 570                 575     

Ala Lys Leu Gly Asp Val Lys Phe Glu Val Gly Ala Gly Ser Trp Asn 
            580                 585                 590         

Gln Gly Asp Phe Asn Tyr Leu Lys Asp Val Gln Lys Asn Asp Ala Thr 
        595                 600                 605             

Lys Val Val Asn Lys Lys Ile Thr Ile Pro Gln Thr Gly Gly Ile Gly 
    610                 615                 620                 

Thr Ile Ile Phe Ala Val Ala Gly Ala Val Ile Met Gly Ile Ala Val 
625                 630                 635                 640 

Tyr Ala Tyr Val Lys Asn Asn Lys Asp Glu Asp Gln Leu Ala 
                645                 650                 

<210>   331
<211>   644
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   RrgB sequence

<400>   331
Met Lys Ser Ile Asn Lys Phe Leu Thr Met Leu Ala Ala Leu Leu Leu 
1               5                   10                  15      

Thr Ala Ser Ser Leu Phe Ser Ala Ala Thr Val Phe Ala Ala Asp Asn 
            20                  25                  30          

Val Ser Thr Ala Pro Asp Ala Val Thr Lys Thr Leu Thr Ile His Lys 
        35                  40                  45              

Leu Leu Leu Ser Glu Asp Asp Leu Lys Thr Trp Asp Thr Asn Gly Pro 
    50                  55                  60                  

Lys Gly Tyr Asp Gly Thr Gln Ser Ser Leu Lys Asp Leu Thr Gly Val 
65                  70                  75                  80  

Val Ala Glu Glu Ile Pro Asn Val Tyr Phe Glu Leu Gln Lys Tyr Asn 
                85                  90                  95      

Leu Thr Asp Gly Lys Glu Lys Glu Asn Leu Lys Asp Asp Ser Lys Trp 
            100                 105                 110         

Thr Thr Val His Gly Gly Leu Thr Thr Lys Asp Gly Leu Lys Ile Glu 
        115                 120                 125             

Thr Ser Thr Leu Lys Gly Val Tyr Arg Ile Arg Glu Asp Arg Thr Lys 
    130                 135                 140                 

Thr Thr Tyr Val Gly Pro Asn Gly Gln Val Leu Thr Gly Ser Lys Ala 
145                 150                 155                 160 

Val Pro Ala Leu Val Thr Leu Pro Leu Val Asn Asn Asn Gly Thr Val 
                165                 170                 175     

Ile Asp Ala His Val Phe Pro Lys Asn Ser Tyr Asn Lys Pro Val Val 
            180                 185                 190         

Asp Lys Arg Ile Ala Asp Thr Leu Asn Tyr Asn Asp Gln Asn Gly Leu 
        195                 200                 205             

Ser Ile Gly Thr Lys Ile Pro Tyr Val Val Asn Thr Thr Ile Pro Ser 
    210                 215                 220                 

Asn Ala Thr Phe Ala Thr Ser Phe Trp Ser Asp Glu Met Thr Glu Gly 
225                 230                 235                 240 

Leu Thr Tyr Asn Glu Asp Val Thr Ile Thr Leu Asn Asn Val Ala Met 
                245                 250                 255     

Asp Gln Ala Asp Tyr Glu Val Thr Lys Gly Ile Asn Gly Phe Asn Leu 
            260                 265                 270         

Lys Leu Thr Glu Ala Gly Leu Ala Lys Ile Asn Gly Lys Asp Ala Asp 
        275                 280                 285             

Gln Lys Ile Gln Ile Thr Tyr Ser Ala Thr Leu Asn Ser Leu Ala Val 
    290                 295                 300                 

Ala Asp Ile Pro Glu Ser Asn Asp Ile Thr Tyr His Tyr Gly Asn His 
305                 310                 315                 320 

Gln Asp His Gly Asn Thr Pro Lys Pro Thr Lys Pro Asn Asn Gly Gln 
                325                 330                 335     

Ile Thr Val Thr Lys Thr Trp Asp Ser Gln Pro Ala Pro Glu Gly Val 
            340                 345                 350         

Lys Ala Thr Val Gln Leu Val Asn Ala Lys Thr Gly Glu Lys Val Gly 
        355                 360                 365             

Ala Pro Val Glu Leu Ser Glu Asn Asn Trp Thr Tyr Thr Trp Ser Gly 
    370                 375                 380                 

Leu Asp Asn Ser Ile Glu Tyr Lys Val Glu Glu Glu Tyr Asn Gly Tyr 
385                 390                 395                 400 

Ser Ala Glu Tyr Thr Val Glu Ser Lys Gly Lys Leu Gly Val Lys Asn 
                405                 410                 415     

Trp Lys Asp Asn Asn Pro Ala Pro Ile Asn Leu Glu Glu Pro Arg Val 
            420                 425                 430         

Lys Thr Tyr Gly Lys Lys Phe Val Lys Val Asp Gln Lys Asp Thr Arg 
        435                 440                 445             

Leu Glu Asn Ala Gln Phe Val Val Lys Lys Ala Asp Ser Asn Lys Tyr 
    450                 455                 460                 

Ile Ala Phe Lys Ser Thr Ala Gln Gln Ala Ala Asp Glu Lys Ala Ala 
465                 470                 475                 480 

Ala Ser Ala Lys Gln Lys Leu Asp Ala Ala Val Ala Ala Tyr Thr Asn 
                485                 490                 495     

Ala Ala Asp Lys Gln Ala Ala Gln Ala Leu Val Asp Gln Ala Gln Gln 
            500                 505                 510         

Glu Tyr Asn Val Ala Tyr Lys Glu Ala Lys Phe Gly Tyr Val Glu Val 
        515                 520                 525             

Ala Gly Lys Asp Glu Ala Met Val Leu Thr Ser Asn Thr Asp Gly Gln 
    530                 535                 540                 

Phe Gln Ile Ser Gly Leu Ala Ala Gly Thr Tyr Lys Leu Glu Glu Ile 
545                 550                 555                 560 

Lys Ala Pro Glu Gly Phe Ala Lys Ile Asp Asp Val Glu Phe Val Val 
                565                 570                 575     

Gly Ala Gly Ser Trp Asn Gln Gly Glu Phe Asn Tyr Leu Lys Asp Val 
            580                 585                 590         

Gln Lys Asn Asp Ala Thr Lys Val Val Asn Lys Lys Ile Thr Ile Pro 
        595                 600                 605             

Gln Thr Gly Gly Ile Gly Thr Ile Ile Phe Ala Val Ala Gly Ala Ala 
    610                 615                 620                 

Ile Met Gly Ile Ala Val Tyr Ala Tyr Val Lys Asn Asn Lys Asp Glu 
625                 630                 635                 640 

Asp Gln Leu Ala 
                

<210>   332
<211>   251
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   fragment of spr2021 (SP2216-1)

<400>   332
Glu Thr Thr Asp Asp Lys Ile Ala Ala Gln Asp Asn Lys Ile Ser Asn 
1               5                   10                  15      

Leu Thr Ala Gln Gln Gln Glu Ala Gln Lys Gln Val Asp Gln Ile Gln 
            20                  25                  30          

Glu Gln Val Ser Ala Ile Gln Ala Glu Gln Ser Asn Leu Gln Ala Glu 
        35                  40                  45              

Asn Asp Arg Leu Gln Ala Glu Ser Lys Lys Leu Glu Gly Glu Ile Thr 
    50                  55                  60                  

Glu Leu Ser Lys Asn Ile Val Ser Arg Asn Gln Ser Leu Glu Lys Gln 
65                  70                  75                  80  

Ala Arg Ser Ala Gln Thr Asn Gly Ala Val Thr Ser Tyr Ile Asn Thr 
                85                  90                  95      

Ile Val Asn Ser Lys Ser Ile Thr Glu Ala Ile Ser Arg Val Ala Ala 
            100                 105                 110         

Met Ser Glu Ile Val Ser Ala Asn Asn Lys Met Leu Glu Gln Gln Lys 
        115                 120                 125             

Ala Asp Lys Lys Ala Ile Ser Glu Lys Gln Val Ala Asn Asn Asp Ala 
    130                 135                 140                 

Ile Asn Thr Val Ile Ala Asn Gln Gln Lys Leu Ala Asp Asp Ala Gln 
145                 150                 155                 160 

Ala Leu Thr Thr Lys Gln Ala Glu Leu Lys Ala Ala Glu Leu Ser Leu 
                165                 170                 175     

Ala Ala Glu Lys Ala Thr Ala Glu Gly Glu Lys Ala Ser Leu Leu Glu 
            180                 185                 190         

Gln Lys Ala Ala Ala Glu Ala Glu Ala Arg Ala Ala Ala Val Ala Glu 
        195                 200                 205             

Ala Ala Tyr Lys Glu Lys Arg Ala Ser Gln Gln Gln Ser Val Leu Ala 
    210                 215                 220                 

Ser Ala Asn Thr Asn Leu Thr Ala Gln Val Gln Ala Val Ser Glu Ser 
225                 230                 235                 240 

Ala Ala Ala Pro Val Arg Ala Lys Val Arg Pro 
                245                 250     

<210>   333
<211>   315
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   SP 1732-3

<400>   333
Tyr Leu Ile Leu Leu Ala Ser Leu Val Leu Val Ala Ala Ser Leu Ile 
1               5                   10                  15      

Trp Ile Leu Ser Arg Thr Pro Ala Thr Ile Ala Ile Pro Asp Val Ala 
            20                  25                  30          

Gly Gln Thr Val Ala Glu Ala Lys Ala Thr Leu Lys Lys Ala Asn Phe 
        35                  40                  45              

Glu Ile Gly Glu Glu Lys Thr Glu Ala Ser Glu Lys Val Glu Glu Gly 
    50                  55                  60                  

Arg Ile Ile Arg Thr Asp Pro Gly Ala Gly Thr Gly Arg Lys Glu Gly 
65                  70                  75                  80  

Thr Lys Ile Asn Leu Val Val Ser Ser Gly Lys Gln Ser Phe Gln Ile 
                85                  90                  95      

Ser Asn Tyr Val Gly Arg Lys Ser Ser Asp Val Ile Ala Glu Leu Lys 
            100                 105                 110         

Glu Lys Lys Val Pro Asp Asn Leu Ile Lys Ile Glu Glu Glu Glu Ser 
        115                 120                 125             

Asn Glu Ser Glu Ala Gly Thr Val Leu Lys Gln Ser Leu Pro Glu Gly 
    130                 135                 140                 

Thr Thr Tyr Asp Leu Ser Lys Ala Thr Gln Ile Val Leu Thr Val Ala 
145                 150                 155                 160 

Lys Lys Ala Thr Thr Ile Gln Leu Gly Asn Tyr Ile Gly Arg Asn Ser 
                165                 170                 175     

Thr Glu Val Ile Ser Glu Leu Lys Gln Lys Lys Val Pro Glu Asn Leu 
            180                 185                 190         

Ile Lys Ile Glu Glu Glu Glu Ser Ser Glu Ser Glu Pro Gly Thr Ile 
        195                 200                 205             

Met Lys Gln Ser Pro Gly Ala Gly Thr Thr Tyr Asp Val Ser Lys Pro 
    210                 215                 220                 

Thr Gln Ile Val Leu Thr Val Ala Lys Lys Val Thr Ser Val Ala Met 
225                 230                 235                 240 

Pro Ser Tyr Ile Gly Ser Ser Leu Glu Phe Thr Lys Asn Asn Leu Ile 
                245                 250                 255     

Gln Ile Val Gly Ile Lys Glu Ala Asn Ile Glu Val Val Glu Val Thr 
            260                 265                 270         

Thr Ala Pro Ala Gly Ser Val Glu Gly Met Val Val Glu Gln Ser Pro 
        275                 280                 285             

Arg Ala Gly Glu Lys Val Asp Leu Asn Lys Thr Arg Val Lys Ile Ser 
    290                 295                 300                 

Ile Tyr Lys Pro Lys Thr Thr Ser Ala Thr Pro 
305                 310                 315 

<210>   334
<211>   289
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PsaA fragment

<400>   334
Ala Ser Gly Lys Lys Asp Thr Thr Ser Gly Gln Lys Leu Lys Val Val 
1               5                   10                  15      

Ala Thr Asn Ser Ile Ile Ala Asp Ile Thr Lys Asn Ile Ala Gly Asp 
            20                  25                  30          

Lys Ile Asp Leu His Ser Ile Val Pro Ile Gly Gln Asp Pro His Glu 
        35                  40                  45              

Tyr Glu Pro Leu Pro Glu Asp Val Lys Lys Thr Ser Glu Ala Asp Leu 
    50                  55                  60                  

Ile Phe Tyr Asn Gly Ile Asn Leu Glu Thr Gly Gly Asn Ala Trp Phe 
65                  70                  75                  80  

Thr Lys Leu Val Glu Asn Ala Lys Lys Thr Glu Asn Lys Asp Tyr Phe 
                85                  90                  95      

Ala Val Ser Asp Gly Val Asp Val Ile Tyr Leu Glu Gly Gln Asn Glu 
            100                 105                 110         

Lys Gly Lys Glu Asp Pro His Ala Trp Leu Asn Leu Glu Asn Gly Ile 
        115                 120                 125             

Ile Phe Ala Lys Asn Ile Ala Lys Gln Leu Ser Ala Lys Asp Pro Asn 
    130                 135                 140                 

Asn Lys Glu Phe Tyr Glu Lys Asn Leu Lys Glu Tyr Thr Asp Lys Leu 
145                 150                 155                 160 

Asp Lys Leu Asp Lys Glu Ser Lys Asp Lys Phe Asn Lys Ile Pro Ala 
                165                 170                 175     

Glu Lys Lys Leu Ile Val Thr Ser Glu Gly Ala Phe Lys Tyr Phe Ser 
            180                 185                 190         

Lys Ala Tyr Gly Val Pro Ser Ala Tyr Ile Trp Glu Ile Asn Thr Glu 
        195                 200                 205             

Glu Glu Gly Thr Pro Glu Gln Ile Lys Thr Leu Val Glu Lys Leu Arg 
    210                 215                 220                 

Gln Thr Lys Val Pro Ser Leu Phe Val Glu Ser Ser Val Asp Asp Arg 
225                 230                 235                 240 

Pro Met Lys Thr Val Ser Gln Asp Thr Asn Ile Pro Ile Tyr Ala Gln 
                245                 250                 255     

Ile Phe Thr Asp Ser Ile Ala Glu Gln Gly Lys Glu Gly Asp Ser Tyr 
            260                 265                 270         

Tyr Ser Met Met Lys Tyr Asn Leu Asp Lys Ile Ala Glu Gly Leu Ala 
        275                 280                 285             

Lys 
    

<210>   335
<211>   20
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   RrgB Clade I D1 Epitope

<400>   335
His Lys Leu Leu Ala Thr Asp Gly Asp Met Asp Lys Ile Ala Asn Glu 
1               5                   10                  15      

Leu Glu Thr Gly 
            20  

<210>   336
<211>   15
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   RrgB Clade I D4 Epitope

<400>   336
Val Thr Thr Lys Asp Ala Leu Asp Arg Ala Val Ala Ala Tyr Asn 
1               5                   10                  15  

<210>   337
<211>   20
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   RrgB Clade II D1 Epitope

<400>   337
Val Thr Lys Thr Leu Thr Ile His Lys Leu Leu Leu Ser Glu Asp Asp 
1               5                   10                  15      

Leu Lys Thr Trp 
            20  

<210>   338
<211>   15
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   RrgB Clade II D4 Epitope

<400>   338
Tyr Thr Asn Ala Ala Asp Lys Gln Ala Ala Gln Ala Leu Val Asp 
1               5                   10                  15  

<210>   339
<211>   20
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   RrgB Clade III D1 Epitope

<400>   339
His Lys Leu Leu Met Thr Asp Gln Glu Leu Asp Ala Trp Asn Ser Asp 
1               5                   10                  15      

Ala Ile Thr Thr 
            20  

<210>   340
<211>   15
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   RrgB Clade III D4 Epitope

<400>   340
Lys Gln Ala Leu Asp Ala Ala Ile Ala Ala Tyr Thr Asn Ala Ala 
1               5                   10                  15  
  
