                         SEQUENCE LISTING

<110>  Synageva Bioharma Corporation
        
<120>  TRUNCATED LYSOSOMAL ACID LIPASE

<130>  121424-00220

<150>  61/605,850
<151>  2012-03-02

<160>  68    

<170>  PatentIn version 3.5

<210>  1
<211>  399
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Lys Met Arg Phe Leu Gly Leu Val Val Cys Leu Val Leu Trp Thr 
1               5                   10                  15      


Leu His Ser Glu Gly Ser Gly Gly Lys Leu Thr Ala Val Asp Pro Glu 
            20                  25                  30          


Thr Asn Met Asn Val Ser Glu Ile Ile Ser Tyr Trp Gly Phe Pro Ser 
        35                  40                  45              


Glu Glu Tyr Leu Val Glu Thr Glu Asp Gly Tyr Ile Leu Cys Leu Asn 
    50                  55                  60                  


Arg Ile Pro His Gly Arg Lys Asn His Ser Asp Lys Gly Pro Lys Pro 
65                  70                  75                  80  


Val Val Phe Leu Gln His Gly Leu Leu Ala Asp Ser Ser Asn Trp Val 
                85                  90                  95      


Thr Asn Leu Ala Asn Ser Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly 
            100                 105                 110         


Phe Asp Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys 
        115                 120                 125             


His Lys Thr Leu Ser Val Ser Gln Asp Glu Phe Trp Ala Phe Ser Tyr 
    130                 135                 140                 


Asp Glu Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn Phe Ile Leu 
145                 150                 155                 160 


Asn Lys Thr Gly Gln Glu Gln Val Tyr Tyr Val Gly His Ser Gln Gly 
                165                 170                 175     


Thr Thr Ile Gly Phe Ile Ala Phe Ser Gln Ile Pro Glu Leu Ala Lys 
            180                 185                 190         


Arg Ile Lys Met Phe Phe Ala Leu Gly Pro Val Ala Ser Val Ala Phe 
        195                 200                 205             


Cys Thr Ser Pro Met Ala Lys Leu Gly Arg Leu Pro Asp His Leu Ile 
    210                 215                 220                 


Lys Asp Leu Phe Gly Asp Lys Glu Phe Leu Pro Gln Ser Ala Phe Leu 
225                 230                 235                 240 


Lys Trp Leu Gly Thr His Val Cys Thr His Val Ile Leu Lys Glu Leu 
                245                 250                 255     


Cys Gly Asn Leu Cys Phe Leu Leu Cys Gly Phe Asn Glu Arg Asn Leu 
            260                 265                 270         


Asn Met Ser Arg Val Asp Val Tyr Thr Thr His Ser Pro Ala Gly Thr 
        275                 280                 285             


Ser Val Gln Asn Met Leu His Trp Ser Gln Ala Val Lys Phe Gln Lys 
    290                 295                 300                 


Phe Gln Ala Phe Asp Trp Gly Ser Ser Ala Lys Asn Tyr Phe His Tyr 
305                 310                 315                 320 


Asn Gln Ser Tyr Pro Pro Thr Tyr Asn Val Lys Asp Met Leu Val Pro 
                325                 330                 335     


Thr Ala Val Trp Ser Gly Gly His Asp Trp Leu Ala Asp Val Tyr Asp 
            340                 345                 350         


Val Asn Ile Leu Leu Thr Gln Ile Thr Asn Leu Val Phe His Glu Ser 
        355                 360                 365             


Ile Pro Glu Trp Glu His Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro 
    370                 375                 380                 


Trp Arg Leu Tyr Asn Lys Ile Ile Asn Leu Met Arg Lys Tyr Gln 
385                 390                 395                 


<210>  2
<211>  315
<212>  PRT
<213>  Homo sapiens

<400>  2

Gln His Gly Leu Leu Ala Asp Ser Ser Asn Trp Val Thr Asn Leu Ala 
1               5                   10                  15      


Asn Ser Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly Phe Asp Val Trp 
            20                  25                  30          


Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys His Lys Thr Leu 
        35                  40                  45              


Ser Val Ser Gln Asp Glu Phe Trp Ala Phe Ser Tyr Asp Glu Met Ala 
    50                  55                  60                  


Lys Tyr Asp Leu Pro Ala Ser Ile Asn Phe Ile Leu Asn Lys Thr Gly 
65                  70                  75                  80  


Gln Glu Gln Val Tyr Tyr Val Gly His Ser Gln Gly Thr Thr Ile Gly 
                85                  90                  95      


Phe Ile Ala Phe Ser Gln Ile Pro Glu Leu Ala Lys Arg Ile Lys Met 
            100                 105                 110         


Phe Phe Ala Leu Gly Pro Val Ala Ser Val Ala Phe Cys Thr Ser Pro 
        115                 120                 125             


Met Ala Lys Leu Gly Arg Leu Pro Asp His Leu Ile Lys Asp Leu Phe 
    130                 135                 140                 


Gly Asp Lys Glu Phe Leu Pro Gln Ser Ala Phe Leu Lys Trp Leu Gly 
145                 150                 155                 160 


Thr His Val Cys Thr His Val Ile Leu Lys Glu Leu Cys Gly Asn Leu 
                165                 170                 175     


Cys Phe Leu Leu Cys Gly Phe Asn Glu Arg Asn Leu Asn Met Ser Arg 
            180                 185                 190         


Val Asp Val Tyr Thr Thr His Ser Pro Ala Gly Thr Ser Val Gln Asn 
        195                 200                 205             


Met Leu His Trp Ser Gln Ala Val Lys Phe Gln Lys Phe Gln Ala Phe 
    210                 215                 220                 


Asp Trp Gly Ser Ser Ala Lys Asn Tyr Phe His Tyr Asn Gln Ser Tyr 
225                 230                 235                 240 


Pro Pro Thr Tyr Asn Val Lys Asp Met Leu Val Pro Thr Ala Val Trp 
                245                 250                 255     


Ser Gly Gly His Asp Trp Leu Ala Asp Val Tyr Asp Val Asn Ile Leu 
            260                 265                 270         


Leu Thr Gln Ile Thr Asn Leu Val Phe His Glu Ser Ile Pro Glu Trp 
        275                 280                 285             


Glu His Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro Trp Arg Leu Tyr 
    290                 295                 300                 


Asn Lys Ile Ile Asn Leu Met Arg Lys Tyr Gln 
305                 310                 315 


<210>  3
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  3

Leu Gln His Gly Leu Leu Ala Asp Ser Ser Asn Trp Val Thr Asn Leu 
1               5                   10                  15      


Ala Asn Ser Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly Phe Asp Val 
            20                  25                  30          


Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys His Lys Thr 
        35                  40                  45              


Leu Ser Val Ser Gln Asp Glu Phe Trp Ala Phe Ser Tyr Asp Glu Met 
    50                  55                  60                  


Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn Phe Ile Leu Asn Lys Thr 
65                  70                  75                  80  


Gly Gln Glu Gln Val Tyr Tyr Val Gly His Ser Gln Gly Thr Thr Ile 
                85                  90                  95      


Gly Phe Ile Ala Phe Ser Gln Ile Pro Glu Leu Ala Lys Arg Ile Lys 
            100                 105                 110         


Met Phe Phe Ala Leu Gly Pro Val Ala Ser Val Ala Phe Cys Thr Ser 
        115                 120                 125             


Pro Met Ala Lys Leu Gly Arg Leu Pro Asp His Leu Ile Lys Asp Leu 
    130                 135                 140                 


Phe Gly Asp Lys Glu Phe Leu Pro Gln Ser Ala Phe Leu Lys Trp Leu 
145                 150                 155                 160 


Gly Thr His Val Cys Thr His Val Ile Leu Lys Glu Leu Cys Gly Asn 
                165                 170                 175     


Leu Cys Phe Leu Leu Cys Gly Phe Asn Glu Arg Asn Leu Asn Met Ser 
            180                 185                 190         


Arg Val Asp Val Tyr Thr Thr His Ser Pro Ala Gly Thr Ser Val Gln 
        195                 200                 205             


Asn Met Leu His Trp Ser Gln Ala Val Lys Phe Gln Lys Phe Gln Ala 
    210                 215                 220                 


Phe Asp Trp Gly Ser Ser Ala Lys Asn Tyr Phe His Tyr Asn Gln Ser 
225                 230                 235                 240 


Tyr Pro Pro Thr Tyr Asn Val Lys Asp Met Leu Val Pro Thr Ala Val 
                245                 250                 255     


Trp Ser Gly Gly His Asp Trp Leu Ala Asp Val Tyr Asp Val Asn Ile 
            260                 265                 270         


Leu Leu Thr Gln Ile Thr Asn Leu Val Phe His Glu Ser Ile Pro Glu 
        275                 280                 285             


Trp Glu His Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro Trp Arg Leu 
    290                 295                 300                 


Tyr Asn Lys Ile Ile Asn Leu Met Arg Lys Tyr Gln 
305                 310                 315     


<210>  4
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  4

Phe Leu Gln His Gly Leu Leu Ala Asp Ser Ser Asn Trp Val Thr Asn 
1               5                   10                  15      


Leu Ala Asn Ser Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly Phe Asp 
            20                  25                  30          


Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys His Lys 
        35                  40                  45              


Thr Leu Ser Val Ser Gln Asp Glu Phe Trp Ala Phe Ser Tyr Asp Glu 
    50                  55                  60                  


Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn Phe Ile Leu Asn Lys 
65                  70                  75                  80  


Thr Gly Gln Glu Gln Val Tyr Tyr Val Gly His Ser Gln Gly Thr Thr 
                85                  90                  95      


Ile Gly Phe Ile Ala Phe Ser Gln Ile Pro Glu Leu Ala Lys Arg Ile 
            100                 105                 110         


Lys Met Phe Phe Ala Leu Gly Pro Val Ala Ser Val Ala Phe Cys Thr 
        115                 120                 125             


Ser Pro Met Ala Lys Leu Gly Arg Leu Pro Asp His Leu Ile Lys Asp 
    130                 135                 140                 


Leu Phe Gly Asp Lys Glu Phe Leu Pro Gln Ser Ala Phe Leu Lys Trp 
145                 150                 155                 160 


Leu Gly Thr His Val Cys Thr His Val Ile Leu Lys Glu Leu Cys Gly 
                165                 170                 175     


Asn Leu Cys Phe Leu Leu Cys Gly Phe Asn Glu Arg Asn Leu Asn Met 
            180                 185                 190         


Ser Arg Val Asp Val Tyr Thr Thr His Ser Pro Ala Gly Thr Ser Val 
        195                 200                 205             


Gln Asn Met Leu His Trp Ser Gln Ala Val Lys Phe Gln Lys Phe Gln 
    210                 215                 220                 


Ala Phe Asp Trp Gly Ser Ser Ala Lys Asn Tyr Phe His Tyr Asn Gln 
225                 230                 235                 240 


Ser Tyr Pro Pro Thr Tyr Asn Val Lys Asp Met Leu Val Pro Thr Ala 
                245                 250                 255     


Val Trp Ser Gly Gly His Asp Trp Leu Ala Asp Val Tyr Asp Val Asn 
            260                 265                 270         


Ile Leu Leu Thr Gln Ile Thr Asn Leu Val Phe His Glu Ser Ile Pro 
        275                 280                 285             


Glu Trp Glu His Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro Trp Arg 
    290                 295                 300                 


Leu Tyr Asn Lys Ile Ile Asn Leu Met Arg Lys Tyr Gln 
305                 310                 315         


<210>  5
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  5

Val Phe Leu Gln His Gly Leu Leu Ala Asp Ser Ser Asn Trp Val Thr 
1               5                   10                  15      


Asn Leu Ala Asn Ser Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly Phe 
            20                  25                  30          


Asp Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys His 
        35                  40                  45              


Lys Thr Leu Ser Val Ser Gln Asp Glu Phe Trp Ala Phe Ser Tyr Asp 
    50                  55                  60                  


Glu Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn Phe Ile Leu Asn 
65                  70                  75                  80  


Lys Thr Gly Gln Glu Gln Val Tyr Tyr Val Gly His Ser Gln Gly Thr 
                85                  90                  95      


Thr Ile Gly Phe Ile Ala Phe Ser Gln Ile Pro Glu Leu Ala Lys Arg 
            100                 105                 110         


Ile Lys Met Phe Phe Ala Leu Gly Pro Val Ala Ser Val Ala Phe Cys 
        115                 120                 125             


Thr Ser Pro Met Ala Lys Leu Gly Arg Leu Pro Asp His Leu Ile Lys 
    130                 135                 140                 


Asp Leu Phe Gly Asp Lys Glu Phe Leu Pro Gln Ser Ala Phe Leu Lys 
145                 150                 155                 160 


Trp Leu Gly Thr His Val Cys Thr His Val Ile Leu Lys Glu Leu Cys 
                165                 170                 175     


Gly Asn Leu Cys Phe Leu Leu Cys Gly Phe Asn Glu Arg Asn Leu Asn 
            180                 185                 190         


Met Ser Arg Val Asp Val Tyr Thr Thr His Ser Pro Ala Gly Thr Ser 
        195                 200                 205             


Val Gln Asn Met Leu His Trp Ser Gln Ala Val Lys Phe Gln Lys Phe 
    210                 215                 220                 


Gln Ala Phe Asp Trp Gly Ser Ser Ala Lys Asn Tyr Phe His Tyr Asn 
225                 230                 235                 240 


Gln Ser Tyr Pro Pro Thr Tyr Asn Val Lys Asp Met Leu Val Pro Thr 
                245                 250                 255     


Ala Val Trp Ser Gly Gly His Asp Trp Leu Ala Asp Val Tyr Asp Val 
            260                 265                 270         


Asn Ile Leu Leu Thr Gln Ile Thr Asn Leu Val Phe His Glu Ser Ile 
        275                 280                 285             


Pro Glu Trp Glu His Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro Trp 
    290                 295                 300                 


Arg Leu Tyr Asn Lys Ile Ile Asn Leu Met Arg Lys Tyr Gln 
305                 310                 315             


<210>  6
<211>  319
<212>  PRT
<213>  Homo sapiens

<400>  6

Val Val Phe Leu Gln His Gly Leu Leu Ala Asp Ser Ser Asn Trp Val 
1               5                   10                  15      


Thr Asn Leu Ala Asn Ser Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly 
            20                  25                  30          


Phe Asp Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys 
        35                  40                  45              


His Lys Thr Leu Ser Val Ser Gln Asp Glu Phe Trp Ala Phe Ser Tyr 
    50                  55                  60                  


Asp Glu Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn Phe Ile Leu 
65                  70                  75                  80  


Asn Lys Thr Gly Gln Glu Gln Val Tyr Tyr Val Gly His Ser Gln Gly 
                85                  90                  95      


Thr Thr Ile Gly Phe Ile Ala Phe Ser Gln Ile Pro Glu Leu Ala Lys 
            100                 105                 110         


Arg Ile Lys Met Phe Phe Ala Leu Gly Pro Val Ala Ser Val Ala Phe 
        115                 120                 125             


Cys Thr Ser Pro Met Ala Lys Leu Gly Arg Leu Pro Asp His Leu Ile 
    130                 135                 140                 


Lys Asp Leu Phe Gly Asp Lys Glu Phe Leu Pro Gln Ser Ala Phe Leu 
145                 150                 155                 160 


Lys Trp Leu Gly Thr His Val Cys Thr His Val Ile Leu Lys Glu Leu 
                165                 170                 175     


Cys Gly Asn Leu Cys Phe Leu Leu Cys Gly Phe Asn Glu Arg Asn Leu 
            180                 185                 190         


Asn Met Ser Arg Val Asp Val Tyr Thr Thr His Ser Pro Ala Gly Thr 
        195                 200                 205             


Ser Val Gln Asn Met Leu His Trp Ser Gln Ala Val Lys Phe Gln Lys 
    210                 215                 220                 


Phe Gln Ala Phe Asp Trp Gly Ser Ser Ala Lys Asn Tyr Phe His Tyr 
225                 230                 235                 240 


Asn Gln Ser Tyr Pro Pro Thr Tyr Asn Val Lys Asp Met Leu Val Pro 
                245                 250                 255     


Thr Ala Val Trp Ser Gly Gly His Asp Trp Leu Ala Asp Val Tyr Asp 
            260                 265                 270         


Val Asn Ile Leu Leu Thr Gln Ile Thr Asn Leu Val Phe His Glu Ser 
        275                 280                 285             


Ile Pro Glu Trp Glu His Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro 
    290                 295                 300                 


Trp Arg Leu Tyr Asn Lys Ile Ile Asn Leu Met Arg Lys Tyr Gln 
305                 310                 315                 


<210>  7
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  7

Pro Val Val Phe Leu Gln His Gly Leu Leu Ala Asp Ser Ser Asn Trp 
1               5                   10                  15      


Val Thr Asn Leu Ala Asn Ser Ser Leu Gly Phe Ile Leu Ala Asp Ala 
            20                  25                  30          


Gly Phe Asp Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg 
        35                  40                  45              


Lys His Lys Thr Leu Ser Val Ser Gln Asp Glu Phe Trp Ala Phe Ser 
    50                  55                  60                  


Tyr Asp Glu Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn Phe Ile 
65                  70                  75                  80  


Leu Asn Lys Thr Gly Gln Glu Gln Val Tyr Tyr Val Gly His Ser Gln 
                85                  90                  95      


Gly Thr Thr Ile Gly Phe Ile Ala Phe Ser Gln Ile Pro Glu Leu Ala 
            100                 105                 110         


Lys Arg Ile Lys Met Phe Phe Ala Leu Gly Pro Val Ala Ser Val Ala 
        115                 120                 125             


Phe Cys Thr Ser Pro Met Ala Lys Leu Gly Arg Leu Pro Asp His Leu 
    130                 135                 140                 


Ile Lys Asp Leu Phe Gly Asp Lys Glu Phe Leu Pro Gln Ser Ala Phe 
145                 150                 155                 160 


Leu Lys Trp Leu Gly Thr His Val Cys Thr His Val Ile Leu Lys Glu 
                165                 170                 175     


Leu Cys Gly Asn Leu Cys Phe Leu Leu Cys Gly Phe Asn Glu Arg Asn 
            180                 185                 190         


Leu Asn Met Ser Arg Val Asp Val Tyr Thr Thr His Ser Pro Ala Gly 
        195                 200                 205             


Thr Ser Val Gln Asn Met Leu His Trp Ser Gln Ala Val Lys Phe Gln 
    210                 215                 220                 


Lys Phe Gln Ala Phe Asp Trp Gly Ser Ser Ala Lys Asn Tyr Phe His 
225                 230                 235                 240 


Tyr Asn Gln Ser Tyr Pro Pro Thr Tyr Asn Val Lys Asp Met Leu Val 
                245                 250                 255     


Pro Thr Ala Val Trp Ser Gly Gly His Asp Trp Leu Ala Asp Val Tyr 
            260                 265                 270         


Asp Val Asn Ile Leu Leu Thr Gln Ile Thr Asn Leu Val Phe His Glu 
        275                 280                 285             


Ser Ile Pro Glu Trp Glu His Leu Asp Phe Ile Trp Gly Leu Asp Ala 
    290                 295                 300                 


Pro Trp Arg Leu Tyr Asn Lys Ile Ile Asn Leu Met Arg Lys Tyr Gln 
305                 310                 315                 320 


<210>  8
<211>  321
<212>  PRT
<213>  Homo sapiens

<400>  8

Lys Pro Val Val Phe Leu Gln His Gly Leu Leu Ala Asp Ser Ser Asn 
1               5                   10                  15      


Trp Val Thr Asn Leu Ala Asn Ser Ser Leu Gly Phe Ile Leu Ala Asp 
            20                  25                  30          


Ala Gly Phe Asp Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser 
        35                  40                  45              


Arg Lys His Lys Thr Leu Ser Val Ser Gln Asp Glu Phe Trp Ala Phe 
    50                  55                  60                  


Ser Tyr Asp Glu Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn Phe 
65                  70                  75                  80  


Ile Leu Asn Lys Thr Gly Gln Glu Gln Val Tyr Tyr Val Gly His Ser 
                85                  90                  95      


Gln Gly Thr Thr Ile Gly Phe Ile Ala Phe Ser Gln Ile Pro Glu Leu 
            100                 105                 110         


Ala Lys Arg Ile Lys Met Phe Phe Ala Leu Gly Pro Val Ala Ser Val 
        115                 120                 125             


Ala Phe Cys Thr Ser Pro Met Ala Lys Leu Gly Arg Leu Pro Asp His 
    130                 135                 140                 


Leu Ile Lys Asp Leu Phe Gly Asp Lys Glu Phe Leu Pro Gln Ser Ala 
145                 150                 155                 160 


Phe Leu Lys Trp Leu Gly Thr His Val Cys Thr His Val Ile Leu Lys 
                165                 170                 175     


Glu Leu Cys Gly Asn Leu Cys Phe Leu Leu Cys Gly Phe Asn Glu Arg 
            180                 185                 190         


Asn Leu Asn Met Ser Arg Val Asp Val Tyr Thr Thr His Ser Pro Ala 
        195                 200                 205             


Gly Thr Ser Val Gln Asn Met Leu His Trp Ser Gln Ala Val Lys Phe 
    210                 215                 220                 


Gln Lys Phe Gln Ala Phe Asp Trp Gly Ser Ser Ala Lys Asn Tyr Phe 
225                 230                 235                 240 


His Tyr Asn Gln Ser Tyr Pro Pro Thr Tyr Asn Val Lys Asp Met Leu 
                245                 250                 255     


Val Pro Thr Ala Val Trp Ser Gly Gly His Asp Trp Leu Ala Asp Val 
            260                 265                 270         


Tyr Asp Val Asn Ile Leu Leu Thr Gln Ile Thr Asn Leu Val Phe His 
        275                 280                 285             


Glu Ser Ile Pro Glu Trp Glu His Leu Asp Phe Ile Trp Gly Leu Asp 
    290                 295                 300                 


Ala Pro Trp Arg Leu Tyr Asn Lys Ile Ile Asn Leu Met Arg Lys Tyr 
305                 310                 315                 320 


Gln 
    


<210>  9
<211>  322
<212>  PRT
<213>  Homo sapiens

<400>  9

Pro Lys Pro Val Val Phe Leu Gln His Gly Leu Leu Ala Asp Ser Ser 
1               5                   10                  15      


Asn Trp Val Thr Asn Leu Ala Asn Ser Ser Leu Gly Phe Ile Leu Ala 
            20                  25                  30          


Asp Ala Gly Phe Asp Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp 
        35                  40                  45              


Ser Arg Lys His Lys Thr Leu Ser Val Ser Gln Asp Glu Phe Trp Ala 
    50                  55                  60                  


Phe Ser Tyr Asp Glu Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn 
65                  70                  75                  80  


Phe Ile Leu Asn Lys Thr Gly Gln Glu Gln Val Tyr Tyr Val Gly His 
                85                  90                  95      


Ser Gln Gly Thr Thr Ile Gly Phe Ile Ala Phe Ser Gln Ile Pro Glu 
            100                 105                 110         


Leu Ala Lys Arg Ile Lys Met Phe Phe Ala Leu Gly Pro Val Ala Ser 
        115                 120                 125             


Val Ala Phe Cys Thr Ser Pro Met Ala Lys Leu Gly Arg Leu Pro Asp 
    130                 135                 140                 


His Leu Ile Lys Asp Leu Phe Gly Asp Lys Glu Phe Leu Pro Gln Ser 
145                 150                 155                 160 


Ala Phe Leu Lys Trp Leu Gly Thr His Val Cys Thr His Val Ile Leu 
                165                 170                 175     


Lys Glu Leu Cys Gly Asn Leu Cys Phe Leu Leu Cys Gly Phe Asn Glu 
            180                 185                 190         


Arg Asn Leu Asn Met Ser Arg Val Asp Val Tyr Thr Thr His Ser Pro 
        195                 200                 205             


Ala Gly Thr Ser Val Gln Asn Met Leu His Trp Ser Gln Ala Val Lys 
    210                 215                 220                 


Phe Gln Lys Phe Gln Ala Phe Asp Trp Gly Ser Ser Ala Lys Asn Tyr 
225                 230                 235                 240 


Phe His Tyr Asn Gln Ser Tyr Pro Pro Thr Tyr Asn Val Lys Asp Met 
                245                 250                 255     


Leu Val Pro Thr Ala Val Trp Ser Gly Gly His Asp Trp Leu Ala Asp 
            260                 265                 270         


Val Tyr Asp Val Asn Ile Leu Leu Thr Gln Ile Thr Asn Leu Val Phe 
        275                 280                 285             


His Glu Ser Ile Pro Glu Trp Glu His Leu Asp Phe Ile Trp Gly Leu 
    290                 295                 300                 


Asp Ala Pro Trp Arg Leu Tyr Asn Lys Ile Ile Asn Leu Met Arg Lys 
305                 310                 315                 320 


Tyr Gln 
        


<210>  10
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  10

Gly Pro Lys Pro Val Val Phe Leu Gln His Gly Leu Leu Ala Asp Ser 
1               5                   10                  15      


Ser Asn Trp Val Thr Asn Leu Ala Asn Ser Ser Leu Gly Phe Ile Leu 
            20                  25                  30          


Ala Asp Ala Gly Phe Asp Val Trp Met Gly Asn Ser Arg Gly Asn Thr 
        35                  40                  45              


Trp Ser Arg Lys His Lys Thr Leu Ser Val Ser Gln Asp Glu Phe Trp 
    50                  55                  60                  


Ala Phe Ser Tyr Asp Glu Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile 
65                  70                  75                  80  


Asn Phe Ile Leu Asn Lys Thr Gly Gln Glu Gln Val Tyr Tyr Val Gly 
                85                  90                  95      


His Ser Gln Gly Thr Thr Ile Gly Phe Ile Ala Phe Ser Gln Ile Pro 
            100                 105                 110         


Glu Leu Ala Lys Arg Ile Lys Met Phe Phe Ala Leu Gly Pro Val Ala 
        115                 120                 125             


Ser Val Ala Phe Cys Thr Ser Pro Met Ala Lys Leu Gly Arg Leu Pro 
    130                 135                 140                 


Asp His Leu Ile Lys Asp Leu Phe Gly Asp Lys Glu Phe Leu Pro Gln 
145                 150                 155                 160 


Ser Ala Phe Leu Lys Trp Leu Gly Thr His Val Cys Thr His Val Ile 
                165                 170                 175     


Leu Lys Glu Leu Cys Gly Asn Leu Cys Phe Leu Leu Cys Gly Phe Asn 
            180                 185                 190         


Glu Arg Asn Leu Asn Met Ser Arg Val Asp Val Tyr Thr Thr His Ser 
        195                 200                 205             


Pro Ala Gly Thr Ser Val Gln Asn Met Leu His Trp Ser Gln Ala Val 
    210                 215                 220                 


Lys Phe Gln Lys Phe Gln Ala Phe Asp Trp Gly Ser Ser Ala Lys Asn 
225                 230                 235                 240 


Tyr Phe His Tyr Asn Gln Ser Tyr Pro Pro Thr Tyr Asn Val Lys Asp 
                245                 250                 255     


Met Leu Val Pro Thr Ala Val Trp Ser Gly Gly His Asp Trp Leu Ala 
            260                 265                 270         


Asp Val Tyr Asp Val Asn Ile Leu Leu Thr Gln Ile Thr Asn Leu Val 
        275                 280                 285             


Phe His Glu Ser Ile Pro Glu Trp Glu His Leu Asp Phe Ile Trp Gly 
    290                 295                 300                 


Leu Asp Ala Pro Trp Arg Leu Tyr Asn Lys Ile Ile Asn Leu Met Arg 
305                 310                 315                 320 


Lys Tyr Gln 
            


<210>  11
<211>  324
<212>  PRT
<213>  Homo sapiens

<400>  11

Lys Gly Pro Lys Pro Val Val Phe Leu Gln His Gly Leu Leu Ala Asp 
1               5                   10                  15      


Ser Ser Asn Trp Val Thr Asn Leu Ala Asn Ser Ser Leu Gly Phe Ile 
            20                  25                  30          


Leu Ala Asp Ala Gly Phe Asp Val Trp Met Gly Asn Ser Arg Gly Asn 
        35                  40                  45              


Thr Trp Ser Arg Lys His Lys Thr Leu Ser Val Ser Gln Asp Glu Phe 
    50                  55                  60                  


Trp Ala Phe Ser Tyr Asp Glu Met Ala Lys Tyr Asp Leu Pro Ala Ser 
65                  70                  75                  80  


Ile Asn Phe Ile Leu Asn Lys Thr Gly Gln Glu Gln Val Tyr Tyr Val 
                85                  90                  95      


Gly His Ser Gln Gly Thr Thr Ile Gly Phe Ile Ala Phe Ser Gln Ile 
            100                 105                 110         


Pro Glu Leu Ala Lys Arg Ile Lys Met Phe Phe Ala Leu Gly Pro Val 
        115                 120                 125             


Ala Ser Val Ala Phe Cys Thr Ser Pro Met Ala Lys Leu Gly Arg Leu 
    130                 135                 140                 


Pro Asp His Leu Ile Lys Asp Leu Phe Gly Asp Lys Glu Phe Leu Pro 
145                 150                 155                 160 


Gln Ser Ala Phe Leu Lys Trp Leu Gly Thr His Val Cys Thr His Val 
                165                 170                 175     


Ile Leu Lys Glu Leu Cys Gly Asn Leu Cys Phe Leu Leu Cys Gly Phe 
            180                 185                 190         


Asn Glu Arg Asn Leu Asn Met Ser Arg Val Asp Val Tyr Thr Thr His 
        195                 200                 205             


Ser Pro Ala Gly Thr Ser Val Gln Asn Met Leu His Trp Ser Gln Ala 
    210                 215                 220                 


Val Lys Phe Gln Lys Phe Gln Ala Phe Asp Trp Gly Ser Ser Ala Lys 
225                 230                 235                 240 


Asn Tyr Phe His Tyr Asn Gln Ser Tyr Pro Pro Thr Tyr Asn Val Lys 
                245                 250                 255     


Asp Met Leu Val Pro Thr Ala Val Trp Ser Gly Gly His Asp Trp Leu 
            260                 265                 270         


Ala Asp Val Tyr Asp Val Asn Ile Leu Leu Thr Gln Ile Thr Asn Leu 
        275                 280                 285             


Val Phe His Glu Ser Ile Pro Glu Trp Glu His Leu Asp Phe Ile Trp 
    290                 295                 300                 


Gly Leu Asp Ala Pro Trp Arg Leu Tyr Asn Lys Ile Ile Asn Leu Met 
305                 310                 315                 320 


Arg Lys Tyr Gln 
                


<210>  12
<211>  325
<212>  PRT
<213>  Homo sapiens

<400>  12

Asp Lys Gly Pro Lys Pro Val Val Phe Leu Gln His Gly Leu Leu Ala 
1               5                   10                  15      


Asp Ser Ser Asn Trp Val Thr Asn Leu Ala Asn Ser Ser Leu Gly Phe 
            20                  25                  30          


Ile Leu Ala Asp Ala Gly Phe Asp Val Trp Met Gly Asn Ser Arg Gly 
        35                  40                  45              


Asn Thr Trp Ser Arg Lys His Lys Thr Leu Ser Val Ser Gln Asp Glu 
    50                  55                  60                  


Phe Trp Ala Phe Ser Tyr Asp Glu Met Ala Lys Tyr Asp Leu Pro Ala 
65                  70                  75                  80  


Ser Ile Asn Phe Ile Leu Asn Lys Thr Gly Gln Glu Gln Val Tyr Tyr 
                85                  90                  95      


Val Gly His Ser Gln Gly Thr Thr Ile Gly Phe Ile Ala Phe Ser Gln 
            100                 105                 110         


Ile Pro Glu Leu Ala Lys Arg Ile Lys Met Phe Phe Ala Leu Gly Pro 
        115                 120                 125             


Val Ala Ser Val Ala Phe Cys Thr Ser Pro Met Ala Lys Leu Gly Arg 
    130                 135                 140                 


Leu Pro Asp His Leu Ile Lys Asp Leu Phe Gly Asp Lys Glu Phe Leu 
145                 150                 155                 160 


Pro Gln Ser Ala Phe Leu Lys Trp Leu Gly Thr His Val Cys Thr His 
                165                 170                 175     


Val Ile Leu Lys Glu Leu Cys Gly Asn Leu Cys Phe Leu Leu Cys Gly 
            180                 185                 190         


Phe Asn Glu Arg Asn Leu Asn Met Ser Arg Val Asp Val Tyr Thr Thr 
        195                 200                 205             


His Ser Pro Ala Gly Thr Ser Val Gln Asn Met Leu His Trp Ser Gln 
    210                 215                 220                 


Ala Val Lys Phe Gln Lys Phe Gln Ala Phe Asp Trp Gly Ser Ser Ala 
225                 230                 235                 240 


Lys Asn Tyr Phe His Tyr Asn Gln Ser Tyr Pro Pro Thr Tyr Asn Val 
                245                 250                 255     


Lys Asp Met Leu Val Pro Thr Ala Val Trp Ser Gly Gly His Asp Trp 
            260                 265                 270         


Leu Ala Asp Val Tyr Asp Val Asn Ile Leu Leu Thr Gln Ile Thr Asn 
        275                 280                 285             


Leu Val Phe His Glu Ser Ile Pro Glu Trp Glu His Leu Asp Phe Ile 
    290                 295                 300                 


Trp Gly Leu Asp Ala Pro Trp Arg Leu Tyr Asn Lys Ile Ile Asn Leu 
305                 310                 315                 320 


Met Arg Lys Tyr Gln 
                325 


<210>  13
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  13

Ser Asp Lys Gly Pro Lys Pro Val Val Phe Leu Gln His Gly Leu Leu 
1               5                   10                  15      


Ala Asp Ser Ser Asn Trp Val Thr Asn Leu Ala Asn Ser Ser Leu Gly 
            20                  25                  30          


Phe Ile Leu Ala Asp Ala Gly Phe Asp Val Trp Met Gly Asn Ser Arg 
        35                  40                  45              


Gly Asn Thr Trp Ser Arg Lys His Lys Thr Leu Ser Val Ser Gln Asp 
    50                  55                  60                  


Glu Phe Trp Ala Phe Ser Tyr Asp Glu Met Ala Lys Tyr Asp Leu Pro 
65                  70                  75                  80  


Ala Ser Ile Asn Phe Ile Leu Asn Lys Thr Gly Gln Glu Gln Val Tyr 
                85                  90                  95      


Tyr Val Gly His Ser Gln Gly Thr Thr Ile Gly Phe Ile Ala Phe Ser 
            100                 105                 110         


Gln Ile Pro Glu Leu Ala Lys Arg Ile Lys Met Phe Phe Ala Leu Gly 
        115                 120                 125             


Pro Val Ala Ser Val Ala Phe Cys Thr Ser Pro Met Ala Lys Leu Gly 
    130                 135                 140                 


Arg Leu Pro Asp His Leu Ile Lys Asp Leu Phe Gly Asp Lys Glu Phe 
145                 150                 155                 160 


Leu Pro Gln Ser Ala Phe Leu Lys Trp Leu Gly Thr His Val Cys Thr 
                165                 170                 175     


His Val Ile Leu Lys Glu Leu Cys Gly Asn Leu Cys Phe Leu Leu Cys 
            180                 185                 190         


Gly Phe Asn Glu Arg Asn Leu Asn Met Ser Arg Val Asp Val Tyr Thr 
        195                 200                 205             


Thr His Ser Pro Ala Gly Thr Ser Val Gln Asn Met Leu His Trp Ser 
    210                 215                 220                 


Gln Ala Val Lys Phe Gln Lys Phe Gln Ala Phe Asp Trp Gly Ser Ser 
225                 230                 235                 240 


Ala Lys Asn Tyr Phe His Tyr Asn Gln Ser Tyr Pro Pro Thr Tyr Asn 
                245                 250                 255     


Val Lys Asp Met Leu Val Pro Thr Ala Val Trp Ser Gly Gly His Asp 
            260                 265                 270         


Trp Leu Ala Asp Val Tyr Asp Val Asn Ile Leu Leu Thr Gln Ile Thr 
        275                 280                 285             


Asn Leu Val Phe His Glu Ser Ile Pro Glu Trp Glu His Leu Asp Phe 
    290                 295                 300                 


Ile Trp Gly Leu Asp Ala Pro Trp Arg Leu Tyr Asn Lys Ile Ile Asn 
305                 310                 315                 320 


Leu Met Arg Lys Tyr Gln 
                325     


<210>  14
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  14

His Ser Asp Lys Gly Pro Lys Pro Val Val Phe Leu Gln His Gly Leu 
1               5                   10                  15      


Leu Ala Asp Ser Ser Asn Trp Val Thr Asn Leu Ala Asn Ser Ser Leu 
            20                  25                  30          


Gly Phe Ile Leu Ala Asp Ala Gly Phe Asp Val Trp Met Gly Asn Ser 
        35                  40                  45              


Arg Gly Asn Thr Trp Ser Arg Lys His Lys Thr Leu Ser Val Ser Gln 
    50                  55                  60                  


Asp Glu Phe Trp Ala Phe Ser Tyr Asp Glu Met Ala Lys Tyr Asp Leu 
65                  70                  75                  80  


Pro Ala Ser Ile Asn Phe Ile Leu Asn Lys Thr Gly Gln Glu Gln Val 
                85                  90                  95      


Tyr Tyr Val Gly His Ser Gln Gly Thr Thr Ile Gly Phe Ile Ala Phe 
            100                 105                 110         


Ser Gln Ile Pro Glu Leu Ala Lys Arg Ile Lys Met Phe Phe Ala Leu 
        115                 120                 125             


Gly Pro Val Ala Ser Val Ala Phe Cys Thr Ser Pro Met Ala Lys Leu 
    130                 135                 140                 


Gly Arg Leu Pro Asp His Leu Ile Lys Asp Leu Phe Gly Asp Lys Glu 
145                 150                 155                 160 


Phe Leu Pro Gln Ser Ala Phe Leu Lys Trp Leu Gly Thr His Val Cys 
                165                 170                 175     


Thr His Val Ile Leu Lys Glu Leu Cys Gly Asn Leu Cys Phe Leu Leu 
            180                 185                 190         


Cys Gly Phe Asn Glu Arg Asn Leu Asn Met Ser Arg Val Asp Val Tyr 
        195                 200                 205             


Thr Thr His Ser Pro Ala Gly Thr Ser Val Gln Asn Met Leu His Trp 
    210                 215                 220                 


Ser Gln Ala Val Lys Phe Gln Lys Phe Gln Ala Phe Asp Trp Gly Ser 
225                 230                 235                 240 


Ser Ala Lys Asn Tyr Phe His Tyr Asn Gln Ser Tyr Pro Pro Thr Tyr 
                245                 250                 255     


Asn Val Lys Asp Met Leu Val Pro Thr Ala Val Trp Ser Gly Gly His 
            260                 265                 270         


Asp Trp Leu Ala Asp Val Tyr Asp Val Asn Ile Leu Leu Thr Gln Ile 
        275                 280                 285             


Thr Asn Leu Val Phe His Glu Ser Ile Pro Glu Trp Glu His Leu Asp 
    290                 295                 300                 


Phe Ile Trp Gly Leu Asp Ala Pro Trp Arg Leu Tyr Asn Lys Ile Ile 
305                 310                 315                 320 


Asn Leu Met Arg Lys Tyr Gln 
                325         


<210>  15
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  15

Asn His Ser Asp Lys Gly Pro Lys Pro Val Val Phe Leu Gln His Gly 
1               5                   10                  15      


Leu Leu Ala Asp Ser Ser Asn Trp Val Thr Asn Leu Ala Asn Ser Ser 
            20                  25                  30          


Leu Gly Phe Ile Leu Ala Asp Ala Gly Phe Asp Val Trp Met Gly Asn 
        35                  40                  45              


Ser Arg Gly Asn Thr Trp Ser Arg Lys His Lys Thr Leu Ser Val Ser 
    50                  55                  60                  


Gln Asp Glu Phe Trp Ala Phe Ser Tyr Asp Glu Met Ala Lys Tyr Asp 
65                  70                  75                  80  


Leu Pro Ala Ser Ile Asn Phe Ile Leu Asn Lys Thr Gly Gln Glu Gln 
                85                  90                  95      


Val Tyr Tyr Val Gly His Ser Gln Gly Thr Thr Ile Gly Phe Ile Ala 
            100                 105                 110         


Phe Ser Gln Ile Pro Glu Leu Ala Lys Arg Ile Lys Met Phe Phe Ala 
        115                 120                 125             


Leu Gly Pro Val Ala Ser Val Ala Phe Cys Thr Ser Pro Met Ala Lys 
    130                 135                 140                 


Leu Gly Arg Leu Pro Asp His Leu Ile Lys Asp Leu Phe Gly Asp Lys 
145                 150                 155                 160 


Glu Phe Leu Pro Gln Ser Ala Phe Leu Lys Trp Leu Gly Thr His Val 
                165                 170                 175     


Cys Thr His Val Ile Leu Lys Glu Leu Cys Gly Asn Leu Cys Phe Leu 
            180                 185                 190         


Leu Cys Gly Phe Asn Glu Arg Asn Leu Asn Met Ser Arg Val Asp Val 
        195                 200                 205             


Tyr Thr Thr His Ser Pro Ala Gly Thr Ser Val Gln Asn Met Leu His 
    210                 215                 220                 


Trp Ser Gln Ala Val Lys Phe Gln Lys Phe Gln Ala Phe Asp Trp Gly 
225                 230                 235                 240 


Ser Ser Ala Lys Asn Tyr Phe His Tyr Asn Gln Ser Tyr Pro Pro Thr 
                245                 250                 255     


Tyr Asn Val Lys Asp Met Leu Val Pro Thr Ala Val Trp Ser Gly Gly 
            260                 265                 270         


His Asp Trp Leu Ala Asp Val Tyr Asp Val Asn Ile Leu Leu Thr Gln 
        275                 280                 285             


Ile Thr Asn Leu Val Phe His Glu Ser Ile Pro Glu Trp Glu His Leu 
    290                 295                 300                 


Asp Phe Ile Trp Gly Leu Asp Ala Pro Trp Arg Leu Tyr Asn Lys Ile 
305                 310                 315                 320 


Ile Asn Leu Met Arg Lys Tyr Gln 
                325             


<210>  16
<211>  329
<212>  PRT
<213>  Homo sapiens

<400>  16

Lys Asn His Ser Asp Lys Gly Pro Lys Pro Val Val Phe Leu Gln His 
1               5                   10                  15      


Gly Leu Leu Ala Asp Ser Ser Asn Trp Val Thr Asn Leu Ala Asn Ser 
            20                  25                  30          


Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly Phe Asp Val Trp Met Gly 
        35                  40                  45              


Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys His Lys Thr Leu Ser Val 
    50                  55                  60                  


Ser Gln Asp Glu Phe Trp Ala Phe Ser Tyr Asp Glu Met Ala Lys Tyr 
65                  70                  75                  80  


Asp Leu Pro Ala Ser Ile Asn Phe Ile Leu Asn Lys Thr Gly Gln Glu 
                85                  90                  95      


Gln Val Tyr Tyr Val Gly His Ser Gln Gly Thr Thr Ile Gly Phe Ile 
            100                 105                 110         


Ala Phe Ser Gln Ile Pro Glu Leu Ala Lys Arg Ile Lys Met Phe Phe 
        115                 120                 125             


Ala Leu Gly Pro Val Ala Ser Val Ala Phe Cys Thr Ser Pro Met Ala 
    130                 135                 140                 


Lys Leu Gly Arg Leu Pro Asp His Leu Ile Lys Asp Leu Phe Gly Asp 
145                 150                 155                 160 


Lys Glu Phe Leu Pro Gln Ser Ala Phe Leu Lys Trp Leu Gly Thr His 
                165                 170                 175     


Val Cys Thr His Val Ile Leu Lys Glu Leu Cys Gly Asn Leu Cys Phe 
            180                 185                 190         


Leu Leu Cys Gly Phe Asn Glu Arg Asn Leu Asn Met Ser Arg Val Asp 
        195                 200                 205             


Val Tyr Thr Thr His Ser Pro Ala Gly Thr Ser Val Gln Asn Met Leu 
    210                 215                 220                 


His Trp Ser Gln Ala Val Lys Phe Gln Lys Phe Gln Ala Phe Asp Trp 
225                 230                 235                 240 


Gly Ser Ser Ala Lys Asn Tyr Phe His Tyr Asn Gln Ser Tyr Pro Pro 
                245                 250                 255     


Thr Tyr Asn Val Lys Asp Met Leu Val Pro Thr Ala Val Trp Ser Gly 
            260                 265                 270         


Gly His Asp Trp Leu Ala Asp Val Tyr Asp Val Asn Ile Leu Leu Thr 
        275                 280                 285             


Gln Ile Thr Asn Leu Val Phe His Glu Ser Ile Pro Glu Trp Glu His 
    290                 295                 300                 


Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro Trp Arg Leu Tyr Asn Lys 
305                 310                 315                 320 


Ile Ile Asn Leu Met Arg Lys Tyr Gln 
                325                 


<210>  17
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  17

Arg Lys Asn His Ser Asp Lys Gly Pro Lys Pro Val Val Phe Leu Gln 
1               5                   10                  15      


His Gly Leu Leu Ala Asp Ser Ser Asn Trp Val Thr Asn Leu Ala Asn 
            20                  25                  30          


Ser Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly Phe Asp Val Trp Met 
        35                  40                  45              


Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys His Lys Thr Leu Ser 
    50                  55                  60                  


Val Ser Gln Asp Glu Phe Trp Ala Phe Ser Tyr Asp Glu Met Ala Lys 
65                  70                  75                  80  


Tyr Asp Leu Pro Ala Ser Ile Asn Phe Ile Leu Asn Lys Thr Gly Gln 
                85                  90                  95      


Glu Gln Val Tyr Tyr Val Gly His Ser Gln Gly Thr Thr Ile Gly Phe 
            100                 105                 110         


Ile Ala Phe Ser Gln Ile Pro Glu Leu Ala Lys Arg Ile Lys Met Phe 
        115                 120                 125             


Phe Ala Leu Gly Pro Val Ala Ser Val Ala Phe Cys Thr Ser Pro Met 
    130                 135                 140                 


Ala Lys Leu Gly Arg Leu Pro Asp His Leu Ile Lys Asp Leu Phe Gly 
145                 150                 155                 160 


Asp Lys Glu Phe Leu Pro Gln Ser Ala Phe Leu Lys Trp Leu Gly Thr 
                165                 170                 175     


His Val Cys Thr His Val Ile Leu Lys Glu Leu Cys Gly Asn Leu Cys 
            180                 185                 190         


Phe Leu Leu Cys Gly Phe Asn Glu Arg Asn Leu Asn Met Ser Arg Val 
        195                 200                 205             


Asp Val Tyr Thr Thr His Ser Pro Ala Gly Thr Ser Val Gln Asn Met 
    210                 215                 220                 


Leu His Trp Ser Gln Ala Val Lys Phe Gln Lys Phe Gln Ala Phe Asp 
225                 230                 235                 240 


Trp Gly Ser Ser Ala Lys Asn Tyr Phe His Tyr Asn Gln Ser Tyr Pro 
                245                 250                 255     


Pro Thr Tyr Asn Val Lys Asp Met Leu Val Pro Thr Ala Val Trp Ser 
            260                 265                 270         


Gly Gly His Asp Trp Leu Ala Asp Val Tyr Asp Val Asn Ile Leu Leu 
        275                 280                 285             


Thr Gln Ile Thr Asn Leu Val Phe His Glu Ser Ile Pro Glu Trp Glu 
    290                 295                 300                 


His Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro Trp Arg Leu Tyr Asn 
305                 310                 315                 320 


Lys Ile Ile Asn Leu Met Arg Lys Tyr Gln 
                325                 330 


<210>  18
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  18

Gly Arg Lys Asn His Ser Asp Lys Gly Pro Lys Pro Val Val Phe Leu 
1               5                   10                  15      


Gln His Gly Leu Leu Ala Asp Ser Ser Asn Trp Val Thr Asn Leu Ala 
            20                  25                  30          


Asn Ser Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly Phe Asp Val Trp 
        35                  40                  45              


Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys His Lys Thr Leu 
    50                  55                  60                  


Ser Val Ser Gln Asp Glu Phe Trp Ala Phe Ser Tyr Asp Glu Met Ala 
65                  70                  75                  80  


Lys Tyr Asp Leu Pro Ala Ser Ile Asn Phe Ile Leu Asn Lys Thr Gly 
                85                  90                  95      


Gln Glu Gln Val Tyr Tyr Val Gly His Ser Gln Gly Thr Thr Ile Gly 
            100                 105                 110         


Phe Ile Ala Phe Ser Gln Ile Pro Glu Leu Ala Lys Arg Ile Lys Met 
        115                 120                 125             


Phe Phe Ala Leu Gly Pro Val Ala Ser Val Ala Phe Cys Thr Ser Pro 
    130                 135                 140                 


Met Ala Lys Leu Gly Arg Leu Pro Asp His Leu Ile Lys Asp Leu Phe 
145                 150                 155                 160 


Gly Asp Lys Glu Phe Leu Pro Gln Ser Ala Phe Leu Lys Trp Leu Gly 
                165                 170                 175     


Thr His Val Cys Thr His Val Ile Leu Lys Glu Leu Cys Gly Asn Leu 
            180                 185                 190         


Cys Phe Leu Leu Cys Gly Phe Asn Glu Arg Asn Leu Asn Met Ser Arg 
        195                 200                 205             


Val Asp Val Tyr Thr Thr His Ser Pro Ala Gly Thr Ser Val Gln Asn 
    210                 215                 220                 


Met Leu His Trp Ser Gln Ala Val Lys Phe Gln Lys Phe Gln Ala Phe 
225                 230                 235                 240 


Asp Trp Gly Ser Ser Ala Lys Asn Tyr Phe His Tyr Asn Gln Ser Tyr 
                245                 250                 255     


Pro Pro Thr Tyr Asn Val Lys Asp Met Leu Val Pro Thr Ala Val Trp 
            260                 265                 270         


Ser Gly Gly His Asp Trp Leu Ala Asp Val Tyr Asp Val Asn Ile Leu 
        275                 280                 285             


Leu Thr Gln Ile Thr Asn Leu Val Phe His Glu Ser Ile Pro Glu Trp 
    290                 295                 300                 


Glu His Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro Trp Arg Leu Tyr 
305                 310                 315                 320 


Asn Lys Ile Ile Asn Leu Met Arg Lys Tyr Gln 
                325                 330     


<210>  19
<211>  332
<212>  PRT
<213>  Homo sapiens

<400>  19

His Gly Arg Lys Asn His Ser Asp Lys Gly Pro Lys Pro Val Val Phe 
1               5                   10                  15      


Leu Gln His Gly Leu Leu Ala Asp Ser Ser Asn Trp Val Thr Asn Leu 
            20                  25                  30          


Ala Asn Ser Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly Phe Asp Val 
        35                  40                  45              


Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys His Lys Thr 
    50                  55                  60                  


Leu Ser Val Ser Gln Asp Glu Phe Trp Ala Phe Ser Tyr Asp Glu Met 
65                  70                  75                  80  


Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn Phe Ile Leu Asn Lys Thr 
                85                  90                  95      


Gly Gln Glu Gln Val Tyr Tyr Val Gly His Ser Gln Gly Thr Thr Ile 
            100                 105                 110         


Gly Phe Ile Ala Phe Ser Gln Ile Pro Glu Leu Ala Lys Arg Ile Lys 
        115                 120                 125             


Met Phe Phe Ala Leu Gly Pro Val Ala Ser Val Ala Phe Cys Thr Ser 
    130                 135                 140                 


Pro Met Ala Lys Leu Gly Arg Leu Pro Asp His Leu Ile Lys Asp Leu 
145                 150                 155                 160 


Phe Gly Asp Lys Glu Phe Leu Pro Gln Ser Ala Phe Leu Lys Trp Leu 
                165                 170                 175     


Gly Thr His Val Cys Thr His Val Ile Leu Lys Glu Leu Cys Gly Asn 
            180                 185                 190         


Leu Cys Phe Leu Leu Cys Gly Phe Asn Glu Arg Asn Leu Asn Met Ser 
        195                 200                 205             


Arg Val Asp Val Tyr Thr Thr His Ser Pro Ala Gly Thr Ser Val Gln 
    210                 215                 220                 


Asn Met Leu His Trp Ser Gln Ala Val Lys Phe Gln Lys Phe Gln Ala 
225                 230                 235                 240 


Phe Asp Trp Gly Ser Ser Ala Lys Asn Tyr Phe His Tyr Asn Gln Ser 
                245                 250                 255     


Tyr Pro Pro Thr Tyr Asn Val Lys Asp Met Leu Val Pro Thr Ala Val 
            260                 265                 270         


Trp Ser Gly Gly His Asp Trp Leu Ala Asp Val Tyr Asp Val Asn Ile 
        275                 280                 285             


Leu Leu Thr Gln Ile Thr Asn Leu Val Phe His Glu Ser Ile Pro Glu 
    290                 295                 300                 


Trp Glu His Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro Trp Arg Leu 
305                 310                 315                 320 


Tyr Asn Lys Ile Ile Asn Leu Met Arg Lys Tyr Gln 
                325                 330         


<210>  20
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  20

Pro His Gly Arg Lys Asn His Ser Asp Lys Gly Pro Lys Pro Val Val 
1               5                   10                  15      


Phe Leu Gln His Gly Leu Leu Ala Asp Ser Ser Asn Trp Val Thr Asn 
            20                  25                  30          


Leu Ala Asn Ser Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly Phe Asp 
        35                  40                  45              


Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys His Lys 
    50                  55                  60                  


Thr Leu Ser Val Ser Gln Asp Glu Phe Trp Ala Phe Ser Tyr Asp Glu 
65                  70                  75                  80  


Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn Phe Ile Leu Asn Lys 
                85                  90                  95      


Thr Gly Gln Glu Gln Val Tyr Tyr Val Gly His Ser Gln Gly Thr Thr 
            100                 105                 110         


Ile Gly Phe Ile Ala Phe Ser Gln Ile Pro Glu Leu Ala Lys Arg Ile 
        115                 120                 125             


Lys Met Phe Phe Ala Leu Gly Pro Val Ala Ser Val Ala Phe Cys Thr 
    130                 135                 140                 


Ser Pro Met Ala Lys Leu Gly Arg Leu Pro Asp His Leu Ile Lys Asp 
145                 150                 155                 160 


Leu Phe Gly Asp Lys Glu Phe Leu Pro Gln Ser Ala Phe Leu Lys Trp 
                165                 170                 175     


Leu Gly Thr His Val Cys Thr His Val Ile Leu Lys Glu Leu Cys Gly 
            180                 185                 190         


Asn Leu Cys Phe Leu Leu Cys Gly Phe Asn Glu Arg Asn Leu Asn Met 
        195                 200                 205             


Ser Arg Val Asp Val Tyr Thr Thr His Ser Pro Ala Gly Thr Ser Val 
    210                 215                 220                 


Gln Asn Met Leu His Trp Ser Gln Ala Val Lys Phe Gln Lys Phe Gln 
225                 230                 235                 240 


Ala Phe Asp Trp Gly Ser Ser Ala Lys Asn Tyr Phe His Tyr Asn Gln 
                245                 250                 255     


Ser Tyr Pro Pro Thr Tyr Asn Val Lys Asp Met Leu Val Pro Thr Ala 
            260                 265                 270         


Val Trp Ser Gly Gly His Asp Trp Leu Ala Asp Val Tyr Asp Val Asn 
        275                 280                 285             


Ile Leu Leu Thr Gln Ile Thr Asn Leu Val Phe His Glu Ser Ile Pro 
    290                 295                 300                 


Glu Trp Glu His Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro Trp Arg 
305                 310                 315                 320 


Leu Tyr Asn Lys Ile Ile Asn Leu Met Arg Lys Tyr Gln 
                325                 330             


<210>  21
<211>  334
<212>  PRT
<213>  Homo sapiens

<400>  21

Ile Pro His Gly Arg Lys Asn His Ser Asp Lys Gly Pro Lys Pro Val 
1               5                   10                  15      


Val Phe Leu Gln His Gly Leu Leu Ala Asp Ser Ser Asn Trp Val Thr 
            20                  25                  30          


Asn Leu Ala Asn Ser Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly Phe 
        35                  40                  45              


Asp Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys His 
    50                  55                  60                  


Lys Thr Leu Ser Val Ser Gln Asp Glu Phe Trp Ala Phe Ser Tyr Asp 
65                  70                  75                  80  


Glu Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn Phe Ile Leu Asn 
                85                  90                  95      


Lys Thr Gly Gln Glu Gln Val Tyr Tyr Val Gly His Ser Gln Gly Thr 
            100                 105                 110         


Thr Ile Gly Phe Ile Ala Phe Ser Gln Ile Pro Glu Leu Ala Lys Arg 
        115                 120                 125             


Ile Lys Met Phe Phe Ala Leu Gly Pro Val Ala Ser Val Ala Phe Cys 
    130                 135                 140                 


Thr Ser Pro Met Ala Lys Leu Gly Arg Leu Pro Asp His Leu Ile Lys 
145                 150                 155                 160 


Asp Leu Phe Gly Asp Lys Glu Phe Leu Pro Gln Ser Ala Phe Leu Lys 
                165                 170                 175     


Trp Leu Gly Thr His Val Cys Thr His Val Ile Leu Lys Glu Leu Cys 
            180                 185                 190         


Gly Asn Leu Cys Phe Leu Leu Cys Gly Phe Asn Glu Arg Asn Leu Asn 
        195                 200                 205             


Met Ser Arg Val Asp Val Tyr Thr Thr His Ser Pro Ala Gly Thr Ser 
    210                 215                 220                 


Val Gln Asn Met Leu His Trp Ser Gln Ala Val Lys Phe Gln Lys Phe 
225                 230                 235                 240 


Gln Ala Phe Asp Trp Gly Ser Ser Ala Lys Asn Tyr Phe His Tyr Asn 
                245                 250                 255     


Gln Ser Tyr Pro Pro Thr Tyr Asn Val Lys Asp Met Leu Val Pro Thr 
            260                 265                 270         


Ala Val Trp Ser Gly Gly His Asp Trp Leu Ala Asp Val Tyr Asp Val 
        275                 280                 285             


Asn Ile Leu Leu Thr Gln Ile Thr Asn Leu Val Phe His Glu Ser Ile 
    290                 295                 300                 


Pro Glu Trp Glu His Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro Trp 
305                 310                 315                 320 


Arg Leu Tyr Asn Lys Ile Ile Asn Leu Met Arg Lys Tyr Gln 
                325                 330                 


<210>  22
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  22

Arg Ile Pro His Gly Arg Lys Asn His Ser Asp Lys Gly Pro Lys Pro 
1               5                   10                  15      


Val Val Phe Leu Gln His Gly Leu Leu Ala Asp Ser Ser Asn Trp Val 
            20                  25                  30          


Thr Asn Leu Ala Asn Ser Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly 
        35                  40                  45              


Phe Asp Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys 
    50                  55                  60                  


His Lys Thr Leu Ser Val Ser Gln Asp Glu Phe Trp Ala Phe Ser Tyr 
65                  70                  75                  80  


Asp Glu Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn Phe Ile Leu 
                85                  90                  95      


Asn Lys Thr Gly Gln Glu Gln Val Tyr Tyr Val Gly His Ser Gln Gly 
            100                 105                 110         


Thr Thr Ile Gly Phe Ile Ala Phe Ser Gln Ile Pro Glu Leu Ala Lys 
        115                 120                 125             


Arg Ile Lys Met Phe Phe Ala Leu Gly Pro Val Ala Ser Val Ala Phe 
    130                 135                 140                 


Cys Thr Ser Pro Met Ala Lys Leu Gly Arg Leu Pro Asp His Leu Ile 
145                 150                 155                 160 


Lys Asp Leu Phe Gly Asp Lys Glu Phe Leu Pro Gln Ser Ala Phe Leu 
                165                 170                 175     


Lys Trp Leu Gly Thr His Val Cys Thr His Val Ile Leu Lys Glu Leu 
            180                 185                 190         


Cys Gly Asn Leu Cys Phe Leu Leu Cys Gly Phe Asn Glu Arg Asn Leu 
        195                 200                 205             


Asn Met Ser Arg Val Asp Val Tyr Thr Thr His Ser Pro Ala Gly Thr 
    210                 215                 220                 


Ser Val Gln Asn Met Leu His Trp Ser Gln Ala Val Lys Phe Gln Lys 
225                 230                 235                 240 


Phe Gln Ala Phe Asp Trp Gly Ser Ser Ala Lys Asn Tyr Phe His Tyr 
                245                 250                 255     


Asn Gln Ser Tyr Pro Pro Thr Tyr Asn Val Lys Asp Met Leu Val Pro 
            260                 265                 270         


Thr Ala Val Trp Ser Gly Gly His Asp Trp Leu Ala Asp Val Tyr Asp 
        275                 280                 285             


Val Asn Ile Leu Leu Thr Gln Ile Thr Asn Leu Val Phe His Glu Ser 
    290                 295                 300                 


Ile Pro Glu Trp Glu His Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro 
305                 310                 315                 320 


Trp Arg Leu Tyr Asn Lys Ile Ile Asn Leu Met Arg Lys Tyr Gln 
                325                 330                 335 


<210>  23
<211>  336
<212>  PRT
<213>  Homo sapiens

<400>  23

Asn Arg Ile Pro His Gly Arg Lys Asn His Ser Asp Lys Gly Pro Lys 
1               5                   10                  15      


Pro Val Val Phe Leu Gln His Gly Leu Leu Ala Asp Ser Ser Asn Trp 
            20                  25                  30          


Val Thr Asn Leu Ala Asn Ser Ser Leu Gly Phe Ile Leu Ala Asp Ala 
        35                  40                  45              


Gly Phe Asp Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg 
    50                  55                  60                  


Lys His Lys Thr Leu Ser Val Ser Gln Asp Glu Phe Trp Ala Phe Ser 
65                  70                  75                  80  


Tyr Asp Glu Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn Phe Ile 
                85                  90                  95      


Leu Asn Lys Thr Gly Gln Glu Gln Val Tyr Tyr Val Gly His Ser Gln 
            100                 105                 110         


Gly Thr Thr Ile Gly Phe Ile Ala Phe Ser Gln Ile Pro Glu Leu Ala 
        115                 120                 125             


Lys Arg Ile Lys Met Phe Phe Ala Leu Gly Pro Val Ala Ser Val Ala 
    130                 135                 140                 


Phe Cys Thr Ser Pro Met Ala Lys Leu Gly Arg Leu Pro Asp His Leu 
145                 150                 155                 160 


Ile Lys Asp Leu Phe Gly Asp Lys Glu Phe Leu Pro Gln Ser Ala Phe 
                165                 170                 175     


Leu Lys Trp Leu Gly Thr His Val Cys Thr His Val Ile Leu Lys Glu 
            180                 185                 190         


Leu Cys Gly Asn Leu Cys Phe Leu Leu Cys Gly Phe Asn Glu Arg Asn 
        195                 200                 205             


Leu Asn Met Ser Arg Val Asp Val Tyr Thr Thr His Ser Pro Ala Gly 
    210                 215                 220                 


Thr Ser Val Gln Asn Met Leu His Trp Ser Gln Ala Val Lys Phe Gln 
225                 230                 235                 240 


Lys Phe Gln Ala Phe Asp Trp Gly Ser Ser Ala Lys Asn Tyr Phe His 
                245                 250                 255     


Tyr Asn Gln Ser Tyr Pro Pro Thr Tyr Asn Val Lys Asp Met Leu Val 
            260                 265                 270         


Pro Thr Ala Val Trp Ser Gly Gly His Asp Trp Leu Ala Asp Val Tyr 
        275                 280                 285             


Asp Val Asn Ile Leu Leu Thr Gln Ile Thr Asn Leu Val Phe His Glu 
    290                 295                 300                 


Ser Ile Pro Glu Trp Glu His Leu Asp Phe Ile Trp Gly Leu Asp Ala 
305                 310                 315                 320 


Pro Trp Arg Leu Tyr Asn Lys Ile Ile Asn Leu Met Arg Lys Tyr Gln 
                325                 330                 335     


<210>  24
<211>  337
<212>  PRT
<213>  Homo sapiens

<400>  24

Leu Asn Arg Ile Pro His Gly Arg Lys Asn His Ser Asp Lys Gly Pro 
1               5                   10                  15      


Lys Pro Val Val Phe Leu Gln His Gly Leu Leu Ala Asp Ser Ser Asn 
            20                  25                  30          


Trp Val Thr Asn Leu Ala Asn Ser Ser Leu Gly Phe Ile Leu Ala Asp 
        35                  40                  45              


Ala Gly Phe Asp Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser 
    50                  55                  60                  


Arg Lys His Lys Thr Leu Ser Val Ser Gln Asp Glu Phe Trp Ala Phe 
65                  70                  75                  80  


Ser Tyr Asp Glu Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn Phe 
                85                  90                  95      


Ile Leu Asn Lys Thr Gly Gln Glu Gln Val Tyr Tyr Val Gly His Ser 
            100                 105                 110         


Gln Gly Thr Thr Ile Gly Phe Ile Ala Phe Ser Gln Ile Pro Glu Leu 
        115                 120                 125             


Ala Lys Arg Ile Lys Met Phe Phe Ala Leu Gly Pro Val Ala Ser Val 
    130                 135                 140                 


Ala Phe Cys Thr Ser Pro Met Ala Lys Leu Gly Arg Leu Pro Asp His 
145                 150                 155                 160 


Leu Ile Lys Asp Leu Phe Gly Asp Lys Glu Phe Leu Pro Gln Ser Ala 
                165                 170                 175     


Phe Leu Lys Trp Leu Gly Thr His Val Cys Thr His Val Ile Leu Lys 
            180                 185                 190         


Glu Leu Cys Gly Asn Leu Cys Phe Leu Leu Cys Gly Phe Asn Glu Arg 
        195                 200                 205             


Asn Leu Asn Met Ser Arg Val Asp Val Tyr Thr Thr His Ser Pro Ala 
    210                 215                 220                 


Gly Thr Ser Val Gln Asn Met Leu His Trp Ser Gln Ala Val Lys Phe 
225                 230                 235                 240 


Gln Lys Phe Gln Ala Phe Asp Trp Gly Ser Ser Ala Lys Asn Tyr Phe 
                245                 250                 255     


His Tyr Asn Gln Ser Tyr Pro Pro Thr Tyr Asn Val Lys Asp Met Leu 
            260                 265                 270         


Val Pro Thr Ala Val Trp Ser Gly Gly His Asp Trp Leu Ala Asp Val 
        275                 280                 285             


Tyr Asp Val Asn Ile Leu Leu Thr Gln Ile Thr Asn Leu Val Phe His 
    290                 295                 300                 


Glu Ser Ile Pro Glu Trp Glu His Leu Asp Phe Ile Trp Gly Leu Asp 
305                 310                 315                 320 


Ala Pro Trp Arg Leu Tyr Asn Lys Ile Ile Asn Leu Met Arg Lys Tyr 
                325                 330                 335     


Gln 
    


<210>  25
<211>  338
<212>  PRT
<213>  Homo sapiens

<400>  25

Cys Leu Asn Arg Ile Pro His Gly Arg Lys Asn His Ser Asp Lys Gly 
1               5                   10                  15      


Pro Lys Pro Val Val Phe Leu Gln His Gly Leu Leu Ala Asp Ser Ser 
            20                  25                  30          


Asn Trp Val Thr Asn Leu Ala Asn Ser Ser Leu Gly Phe Ile Leu Ala 
        35                  40                  45              


Asp Ala Gly Phe Asp Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp 
    50                  55                  60                  


Ser Arg Lys His Lys Thr Leu Ser Val Ser Gln Asp Glu Phe Trp Ala 
65                  70                  75                  80  


Phe Ser Tyr Asp Glu Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn 
                85                  90                  95      


Phe Ile Leu Asn Lys Thr Gly Gln Glu Gln Val Tyr Tyr Val Gly His 
            100                 105                 110         


Ser Gln Gly Thr Thr Ile Gly Phe Ile Ala Phe Ser Gln Ile Pro Glu 
        115                 120                 125             


Leu Ala Lys Arg Ile Lys Met Phe Phe Ala Leu Gly Pro Val Ala Ser 
    130                 135                 140                 


Val Ala Phe Cys Thr Ser Pro Met Ala Lys Leu Gly Arg Leu Pro Asp 
145                 150                 155                 160 


His Leu Ile Lys Asp Leu Phe Gly Asp Lys Glu Phe Leu Pro Gln Ser 
                165                 170                 175     


Ala Phe Leu Lys Trp Leu Gly Thr His Val Cys Thr His Val Ile Leu 
            180                 185                 190         


Lys Glu Leu Cys Gly Asn Leu Cys Phe Leu Leu Cys Gly Phe Asn Glu 
        195                 200                 205             


Arg Asn Leu Asn Met Ser Arg Val Asp Val Tyr Thr Thr His Ser Pro 
    210                 215                 220                 


Ala Gly Thr Ser Val Gln Asn Met Leu His Trp Ser Gln Ala Val Lys 
225                 230                 235                 240 


Phe Gln Lys Phe Gln Ala Phe Asp Trp Gly Ser Ser Ala Lys Asn Tyr 
                245                 250                 255     


Phe His Tyr Asn Gln Ser Tyr Pro Pro Thr Tyr Asn Val Lys Asp Met 
            260                 265                 270         


Leu Val Pro Thr Ala Val Trp Ser Gly Gly His Asp Trp Leu Ala Asp 
        275                 280                 285             


Val Tyr Asp Val Asn Ile Leu Leu Thr Gln Ile Thr Asn Leu Val Phe 
    290                 295                 300                 


His Glu Ser Ile Pro Glu Trp Glu His Leu Asp Phe Ile Trp Gly Leu 
305                 310                 315                 320 


Asp Ala Pro Trp Arg Leu Tyr Asn Lys Ile Ile Asn Leu Met Arg Lys 
                325                 330                 335     


Tyr Gln 
        


<210>  26
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  26

Leu Cys Leu Asn Arg Ile Pro His Gly Arg Lys Asn His Ser Asp Lys 
1               5                   10                  15      


Gly Pro Lys Pro Val Val Phe Leu Gln His Gly Leu Leu Ala Asp Ser 
            20                  25                  30          


Ser Asn Trp Val Thr Asn Leu Ala Asn Ser Ser Leu Gly Phe Ile Leu 
        35                  40                  45              


Ala Asp Ala Gly Phe Asp Val Trp Met Gly Asn Ser Arg Gly Asn Thr 
    50                  55                  60                  


Trp Ser Arg Lys His Lys Thr Leu Ser Val Ser Gln Asp Glu Phe Trp 
65                  70                  75                  80  


Ala Phe Ser Tyr Asp Glu Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile 
                85                  90                  95      


Asn Phe Ile Leu Asn Lys Thr Gly Gln Glu Gln Val Tyr Tyr Val Gly 
            100                 105                 110         


His Ser Gln Gly Thr Thr Ile Gly Phe Ile Ala Phe Ser Gln Ile Pro 
        115                 120                 125             


Glu Leu Ala Lys Arg Ile Lys Met Phe Phe Ala Leu Gly Pro Val Ala 
    130                 135                 140                 


Ser Val Ala Phe Cys Thr Ser Pro Met Ala Lys Leu Gly Arg Leu Pro 
145                 150                 155                 160 


Asp His Leu Ile Lys Asp Leu Phe Gly Asp Lys Glu Phe Leu Pro Gln 
                165                 170                 175     


Ser Ala Phe Leu Lys Trp Leu Gly Thr His Val Cys Thr His Val Ile 
            180                 185                 190         


Leu Lys Glu Leu Cys Gly Asn Leu Cys Phe Leu Leu Cys Gly Phe Asn 
        195                 200                 205             


Glu Arg Asn Leu Asn Met Ser Arg Val Asp Val Tyr Thr Thr His Ser 
    210                 215                 220                 


Pro Ala Gly Thr Ser Val Gln Asn Met Leu His Trp Ser Gln Ala Val 
225                 230                 235                 240 


Lys Phe Gln Lys Phe Gln Ala Phe Asp Trp Gly Ser Ser Ala Lys Asn 
                245                 250                 255     


Tyr Phe His Tyr Asn Gln Ser Tyr Pro Pro Thr Tyr Asn Val Lys Asp 
            260                 265                 270         


Met Leu Val Pro Thr Ala Val Trp Ser Gly Gly His Asp Trp Leu Ala 
        275                 280                 285             


Asp Val Tyr Asp Val Asn Ile Leu Leu Thr Gln Ile Thr Asn Leu Val 
    290                 295                 300                 


Phe His Glu Ser Ile Pro Glu Trp Glu His Leu Asp Phe Ile Trp Gly 
305                 310                 315                 320 


Leu Asp Ala Pro Trp Arg Leu Tyr Asn Lys Ile Ile Asn Leu Met Arg 
                325                 330                 335     


Lys Tyr Gln 
            


<210>  27
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  27

Ile Leu Cys Leu Asn Arg Ile Pro His Gly Arg Lys Asn His Ser Asp 
1               5                   10                  15      


Lys Gly Pro Lys Pro Val Val Phe Leu Gln His Gly Leu Leu Ala Asp 
            20                  25                  30          


Ser Ser Asn Trp Val Thr Asn Leu Ala Asn Ser Ser Leu Gly Phe Ile 
        35                  40                  45              


Leu Ala Asp Ala Gly Phe Asp Val Trp Met Gly Asn Ser Arg Gly Asn 
    50                  55                  60                  


Thr Trp Ser Arg Lys His Lys Thr Leu Ser Val Ser Gln Asp Glu Phe 
65                  70                  75                  80  


Trp Ala Phe Ser Tyr Asp Glu Met Ala Lys Tyr Asp Leu Pro Ala Ser 
                85                  90                  95      


Ile Asn Phe Ile Leu Asn Lys Thr Gly Gln Glu Gln Val Tyr Tyr Val 
            100                 105                 110         


Gly His Ser Gln Gly Thr Thr Ile Gly Phe Ile Ala Phe Ser Gln Ile 
        115                 120                 125             


Pro Glu Leu Ala Lys Arg Ile Lys Met Phe Phe Ala Leu Gly Pro Val 
    130                 135                 140                 


Ala Ser Val Ala Phe Cys Thr Ser Pro Met Ala Lys Leu Gly Arg Leu 
145                 150                 155                 160 


Pro Asp His Leu Ile Lys Asp Leu Phe Gly Asp Lys Glu Phe Leu Pro 
                165                 170                 175     


Gln Ser Ala Phe Leu Lys Trp Leu Gly Thr His Val Cys Thr His Val 
            180                 185                 190         


Ile Leu Lys Glu Leu Cys Gly Asn Leu Cys Phe Leu Leu Cys Gly Phe 
        195                 200                 205             


Asn Glu Arg Asn Leu Asn Met Ser Arg Val Asp Val Tyr Thr Thr His 
    210                 215                 220                 


Ser Pro Ala Gly Thr Ser Val Gln Asn Met Leu His Trp Ser Gln Ala 
225                 230                 235                 240 


Val Lys Phe Gln Lys Phe Gln Ala Phe Asp Trp Gly Ser Ser Ala Lys 
                245                 250                 255     


Asn Tyr Phe His Tyr Asn Gln Ser Tyr Pro Pro Thr Tyr Asn Val Lys 
            260                 265                 270         


Asp Met Leu Val Pro Thr Ala Val Trp Ser Gly Gly His Asp Trp Leu 
        275                 280                 285             


Ala Asp Val Tyr Asp Val Asn Ile Leu Leu Thr Gln Ile Thr Asn Leu 
    290                 295                 300                 


Val Phe His Glu Ser Ile Pro Glu Trp Glu His Leu Asp Phe Ile Trp 
305                 310                 315                 320 


Gly Leu Asp Ala Pro Trp Arg Leu Tyr Asn Lys Ile Ile Asn Leu Met 
                325                 330                 335     


Arg Lys Tyr Gln 
            340 


<210>  28
<211>  341
<212>  PRT
<213>  Homo sapiens

<400>  28

Tyr Ile Leu Cys Leu Asn Arg Ile Pro His Gly Arg Lys Asn His Ser 
1               5                   10                  15      


Asp Lys Gly Pro Lys Pro Val Val Phe Leu Gln His Gly Leu Leu Ala 
            20                  25                  30          


Asp Ser Ser Asn Trp Val Thr Asn Leu Ala Asn Ser Ser Leu Gly Phe 
        35                  40                  45              


Ile Leu Ala Asp Ala Gly Phe Asp Val Trp Met Gly Asn Ser Arg Gly 
    50                  55                  60                  


Asn Thr Trp Ser Arg Lys His Lys Thr Leu Ser Val Ser Gln Asp Glu 
65                  70                  75                  80  


Phe Trp Ala Phe Ser Tyr Asp Glu Met Ala Lys Tyr Asp Leu Pro Ala 
                85                  90                  95      


Ser Ile Asn Phe Ile Leu Asn Lys Thr Gly Gln Glu Gln Val Tyr Tyr 
            100                 105                 110         


Val Gly His Ser Gln Gly Thr Thr Ile Gly Phe Ile Ala Phe Ser Gln 
        115                 120                 125             


Ile Pro Glu Leu Ala Lys Arg Ile Lys Met Phe Phe Ala Leu Gly Pro 
    130                 135                 140                 


Val Ala Ser Val Ala Phe Cys Thr Ser Pro Met Ala Lys Leu Gly Arg 
145                 150                 155                 160 


Leu Pro Asp His Leu Ile Lys Asp Leu Phe Gly Asp Lys Glu Phe Leu 
                165                 170                 175     


Pro Gln Ser Ala Phe Leu Lys Trp Leu Gly Thr His Val Cys Thr His 
            180                 185                 190         


Val Ile Leu Lys Glu Leu Cys Gly Asn Leu Cys Phe Leu Leu Cys Gly 
        195                 200                 205             


Phe Asn Glu Arg Asn Leu Asn Met Ser Arg Val Asp Val Tyr Thr Thr 
    210                 215                 220                 


His Ser Pro Ala Gly Thr Ser Val Gln Asn Met Leu His Trp Ser Gln 
225                 230                 235                 240 


Ala Val Lys Phe Gln Lys Phe Gln Ala Phe Asp Trp Gly Ser Ser Ala 
                245                 250                 255     


Lys Asn Tyr Phe His Tyr Asn Gln Ser Tyr Pro Pro Thr Tyr Asn Val 
            260                 265                 270         


Lys Asp Met Leu Val Pro Thr Ala Val Trp Ser Gly Gly His Asp Trp 
        275                 280                 285             


Leu Ala Asp Val Tyr Asp Val Asn Ile Leu Leu Thr Gln Ile Thr Asn 
    290                 295                 300                 


Leu Val Phe His Glu Ser Ile Pro Glu Trp Glu His Leu Asp Phe Ile 
305                 310                 315                 320 


Trp Gly Leu Asp Ala Pro Trp Arg Leu Tyr Asn Lys Ile Ile Asn Leu 
                325                 330                 335     


Met Arg Lys Tyr Gln 
            340     


<210>  29
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  29

Gly Tyr Ile Leu Cys Leu Asn Arg Ile Pro His Gly Arg Lys Asn His 
1               5                   10                  15      


Ser Asp Lys Gly Pro Lys Pro Val Val Phe Leu Gln His Gly Leu Leu 
            20                  25                  30          


Ala Asp Ser Ser Asn Trp Val Thr Asn Leu Ala Asn Ser Ser Leu Gly 
        35                  40                  45              


Phe Ile Leu Ala Asp Ala Gly Phe Asp Val Trp Met Gly Asn Ser Arg 
    50                  55                  60                  


Gly Asn Thr Trp Ser Arg Lys His Lys Thr Leu Ser Val Ser Gln Asp 
65                  70                  75                  80  


Glu Phe Trp Ala Phe Ser Tyr Asp Glu Met Ala Lys Tyr Asp Leu Pro 
                85                  90                  95      


Ala Ser Ile Asn Phe Ile Leu Asn Lys Thr Gly Gln Glu Gln Val Tyr 
            100                 105                 110         


Tyr Val Gly His Ser Gln Gly Thr Thr Ile Gly Phe Ile Ala Phe Ser 
        115                 120                 125             


Gln Ile Pro Glu Leu Ala Lys Arg Ile Lys Met Phe Phe Ala Leu Gly 
    130                 135                 140                 


Pro Val Ala Ser Val Ala Phe Cys Thr Ser Pro Met Ala Lys Leu Gly 
145                 150                 155                 160 


Arg Leu Pro Asp His Leu Ile Lys Asp Leu Phe Gly Asp Lys Glu Phe 
                165                 170                 175     


Leu Pro Gln Ser Ala Phe Leu Lys Trp Leu Gly Thr His Val Cys Thr 
            180                 185                 190         


His Val Ile Leu Lys Glu Leu Cys Gly Asn Leu Cys Phe Leu Leu Cys 
        195                 200                 205             


Gly Phe Asn Glu Arg Asn Leu Asn Met Ser Arg Val Asp Val Tyr Thr 
    210                 215                 220                 


Thr His Ser Pro Ala Gly Thr Ser Val Gln Asn Met Leu His Trp Ser 
225                 230                 235                 240 


Gln Ala Val Lys Phe Gln Lys Phe Gln Ala Phe Asp Trp Gly Ser Ser 
                245                 250                 255     


Ala Lys Asn Tyr Phe His Tyr Asn Gln Ser Tyr Pro Pro Thr Tyr Asn 
            260                 265                 270         


Val Lys Asp Met Leu Val Pro Thr Ala Val Trp Ser Gly Gly His Asp 
        275                 280                 285             


Trp Leu Ala Asp Val Tyr Asp Val Asn Ile Leu Leu Thr Gln Ile Thr 
    290                 295                 300                 


Asn Leu Val Phe His Glu Ser Ile Pro Glu Trp Glu His Leu Asp Phe 
305                 310                 315                 320 


Ile Trp Gly Leu Asp Ala Pro Trp Arg Leu Tyr Asn Lys Ile Ile Asn 
                325                 330                 335     


Leu Met Arg Lys Tyr Gln 
            340         


<210>  30
<211>  343
<212>  PRT
<213>  Homo sapiens

<400>  30

Asp Gly Tyr Ile Leu Cys Leu Asn Arg Ile Pro His Gly Arg Lys Asn 
1               5                   10                  15      


His Ser Asp Lys Gly Pro Lys Pro Val Val Phe Leu Gln His Gly Leu 
            20                  25                  30          


Leu Ala Asp Ser Ser Asn Trp Val Thr Asn Leu Ala Asn Ser Ser Leu 
        35                  40                  45              


Gly Phe Ile Leu Ala Asp Ala Gly Phe Asp Val Trp Met Gly Asn Ser 
    50                  55                  60                  


Arg Gly Asn Thr Trp Ser Arg Lys His Lys Thr Leu Ser Val Ser Gln 
65                  70                  75                  80  


Asp Glu Phe Trp Ala Phe Ser Tyr Asp Glu Met Ala Lys Tyr Asp Leu 
                85                  90                  95      


Pro Ala Ser Ile Asn Phe Ile Leu Asn Lys Thr Gly Gln Glu Gln Val 
            100                 105                 110         


Tyr Tyr Val Gly His Ser Gln Gly Thr Thr Ile Gly Phe Ile Ala Phe 
        115                 120                 125             


Ser Gln Ile Pro Glu Leu Ala Lys Arg Ile Lys Met Phe Phe Ala Leu 
    130                 135                 140                 


Gly Pro Val Ala Ser Val Ala Phe Cys Thr Ser Pro Met Ala Lys Leu 
145                 150                 155                 160 


Gly Arg Leu Pro Asp His Leu Ile Lys Asp Leu Phe Gly Asp Lys Glu 
                165                 170                 175     


Phe Leu Pro Gln Ser Ala Phe Leu Lys Trp Leu Gly Thr His Val Cys 
            180                 185                 190         


Thr His Val Ile Leu Lys Glu Leu Cys Gly Asn Leu Cys Phe Leu Leu 
        195                 200                 205             


Cys Gly Phe Asn Glu Arg Asn Leu Asn Met Ser Arg Val Asp Val Tyr 
    210                 215                 220                 


Thr Thr His Ser Pro Ala Gly Thr Ser Val Gln Asn Met Leu His Trp 
225                 230                 235                 240 


Ser Gln Ala Val Lys Phe Gln Lys Phe Gln Ala Phe Asp Trp Gly Ser 
                245                 250                 255     


Ser Ala Lys Asn Tyr Phe His Tyr Asn Gln Ser Tyr Pro Pro Thr Tyr 
            260                 265                 270         


Asn Val Lys Asp Met Leu Val Pro Thr Ala Val Trp Ser Gly Gly His 
        275                 280                 285             


Asp Trp Leu Ala Asp Val Tyr Asp Val Asn Ile Leu Leu Thr Gln Ile 
    290                 295                 300                 


Thr Asn Leu Val Phe His Glu Ser Ile Pro Glu Trp Glu His Leu Asp 
305                 310                 315                 320 


Phe Ile Trp Gly Leu Asp Ala Pro Trp Arg Leu Tyr Asn Lys Ile Ile 
                325                 330                 335     


Asn Leu Met Arg Lys Tyr Gln 
            340             


<210>  31
<211>  344
<212>  PRT
<213>  Homo sapiens

<400>  31

Glu Asp Gly Tyr Ile Leu Cys Leu Asn Arg Ile Pro His Gly Arg Lys 
1               5                   10                  15      


Asn His Ser Asp Lys Gly Pro Lys Pro Val Val Phe Leu Gln His Gly 
            20                  25                  30          


Leu Leu Ala Asp Ser Ser Asn Trp Val Thr Asn Leu Ala Asn Ser Ser 
        35                  40                  45              


Leu Gly Phe Ile Leu Ala Asp Ala Gly Phe Asp Val Trp Met Gly Asn 
    50                  55                  60                  


Ser Arg Gly Asn Thr Trp Ser Arg Lys His Lys Thr Leu Ser Val Ser 
65                  70                  75                  80  


Gln Asp Glu Phe Trp Ala Phe Ser Tyr Asp Glu Met Ala Lys Tyr Asp 
                85                  90                  95      


Leu Pro Ala Ser Ile Asn Phe Ile Leu Asn Lys Thr Gly Gln Glu Gln 
            100                 105                 110         


Val Tyr Tyr Val Gly His Ser Gln Gly Thr Thr Ile Gly Phe Ile Ala 
        115                 120                 125             


Phe Ser Gln Ile Pro Glu Leu Ala Lys Arg Ile Lys Met Phe Phe Ala 
    130                 135                 140                 


Leu Gly Pro Val Ala Ser Val Ala Phe Cys Thr Ser Pro Met Ala Lys 
145                 150                 155                 160 


Leu Gly Arg Leu Pro Asp His Leu Ile Lys Asp Leu Phe Gly Asp Lys 
                165                 170                 175     


Glu Phe Leu Pro Gln Ser Ala Phe Leu Lys Trp Leu Gly Thr His Val 
            180                 185                 190         


Cys Thr His Val Ile Leu Lys Glu Leu Cys Gly Asn Leu Cys Phe Leu 
        195                 200                 205             


Leu Cys Gly Phe Asn Glu Arg Asn Leu Asn Met Ser Arg Val Asp Val 
    210                 215                 220                 


Tyr Thr Thr His Ser Pro Ala Gly Thr Ser Val Gln Asn Met Leu His 
225                 230                 235                 240 


Trp Ser Gln Ala Val Lys Phe Gln Lys Phe Gln Ala Phe Asp Trp Gly 
                245                 250                 255     


Ser Ser Ala Lys Asn Tyr Phe His Tyr Asn Gln Ser Tyr Pro Pro Thr 
            260                 265                 270         


Tyr Asn Val Lys Asp Met Leu Val Pro Thr Ala Val Trp Ser Gly Gly 
        275                 280                 285             


His Asp Trp Leu Ala Asp Val Tyr Asp Val Asn Ile Leu Leu Thr Gln 
    290                 295                 300                 


Ile Thr Asn Leu Val Phe His Glu Ser Ile Pro Glu Trp Glu His Leu 
305                 310                 315                 320 


Asp Phe Ile Trp Gly Leu Asp Ala Pro Trp Arg Leu Tyr Asn Lys Ile 
                325                 330                 335     


Ile Asn Leu Met Arg Lys Tyr Gln 
            340                 


<210>  32
<211>  345
<212>  PRT
<213>  Homo sapiens

<400>  32

Thr Glu Asp Gly Tyr Ile Leu Cys Leu Asn Arg Ile Pro His Gly Arg 
1               5                   10                  15      


Lys Asn His Ser Asp Lys Gly Pro Lys Pro Val Val Phe Leu Gln His 
            20                  25                  30          


Gly Leu Leu Ala Asp Ser Ser Asn Trp Val Thr Asn Leu Ala Asn Ser 
        35                  40                  45              


Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly Phe Asp Val Trp Met Gly 
    50                  55                  60                  


Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys His Lys Thr Leu Ser Val 
65                  70                  75                  80  


Ser Gln Asp Glu Phe Trp Ala Phe Ser Tyr Asp Glu Met Ala Lys Tyr 
                85                  90                  95      


Asp Leu Pro Ala Ser Ile Asn Phe Ile Leu Asn Lys Thr Gly Gln Glu 
            100                 105                 110         


Gln Val Tyr Tyr Val Gly His Ser Gln Gly Thr Thr Ile Gly Phe Ile 
        115                 120                 125             


Ala Phe Ser Gln Ile Pro Glu Leu Ala Lys Arg Ile Lys Met Phe Phe 
    130                 135                 140                 


Ala Leu Gly Pro Val Ala Ser Val Ala Phe Cys Thr Ser Pro Met Ala 
145                 150                 155                 160 


Lys Leu Gly Arg Leu Pro Asp His Leu Ile Lys Asp Leu Phe Gly Asp 
                165                 170                 175     


Lys Glu Phe Leu Pro Gln Ser Ala Phe Leu Lys Trp Leu Gly Thr His 
            180                 185                 190         


Val Cys Thr His Val Ile Leu Lys Glu Leu Cys Gly Asn Leu Cys Phe 
        195                 200                 205             


Leu Leu Cys Gly Phe Asn Glu Arg Asn Leu Asn Met Ser Arg Val Asp 
    210                 215                 220                 


Val Tyr Thr Thr His Ser Pro Ala Gly Thr Ser Val Gln Asn Met Leu 
225                 230                 235                 240 


His Trp Ser Gln Ala Val Lys Phe Gln Lys Phe Gln Ala Phe Asp Trp 
                245                 250                 255     


Gly Ser Ser Ala Lys Asn Tyr Phe His Tyr Asn Gln Ser Tyr Pro Pro 
            260                 265                 270         


Thr Tyr Asn Val Lys Asp Met Leu Val Pro Thr Ala Val Trp Ser Gly 
        275                 280                 285             


Gly His Asp Trp Leu Ala Asp Val Tyr Asp Val Asn Ile Leu Leu Thr 
    290                 295                 300                 


Gln Ile Thr Asn Leu Val Phe His Glu Ser Ile Pro Glu Trp Glu His 
305                 310                 315                 320 


Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro Trp Arg Leu Tyr Asn Lys 
                325                 330                 335     


Ile Ile Asn Leu Met Arg Lys Tyr Gln 
            340                 345 


<210>  33
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  33

Glu Thr Glu Asp Gly Tyr Ile Leu Cys Leu Asn Arg Ile Pro His Gly 
1               5                   10                  15      


Arg Lys Asn His Ser Asp Lys Gly Pro Lys Pro Val Val Phe Leu Gln 
            20                  25                  30          


His Gly Leu Leu Ala Asp Ser Ser Asn Trp Val Thr Asn Leu Ala Asn 
        35                  40                  45              


Ser Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly Phe Asp Val Trp Met 
    50                  55                  60                  


Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys His Lys Thr Leu Ser 
65                  70                  75                  80  


Val Ser Gln Asp Glu Phe Trp Ala Phe Ser Tyr Asp Glu Met Ala Lys 
                85                  90                  95      


Tyr Asp Leu Pro Ala Ser Ile Asn Phe Ile Leu Asn Lys Thr Gly Gln 
            100                 105                 110         


Glu Gln Val Tyr Tyr Val Gly His Ser Gln Gly Thr Thr Ile Gly Phe 
        115                 120                 125             


Ile Ala Phe Ser Gln Ile Pro Glu Leu Ala Lys Arg Ile Lys Met Phe 
    130                 135                 140                 


Phe Ala Leu Gly Pro Val Ala Ser Val Ala Phe Cys Thr Ser Pro Met 
145                 150                 155                 160 


Ala Lys Leu Gly Arg Leu Pro Asp His Leu Ile Lys Asp Leu Phe Gly 
                165                 170                 175     


Asp Lys Glu Phe Leu Pro Gln Ser Ala Phe Leu Lys Trp Leu Gly Thr 
            180                 185                 190         


His Val Cys Thr His Val Ile Leu Lys Glu Leu Cys Gly Asn Leu Cys 
        195                 200                 205             


Phe Leu Leu Cys Gly Phe Asn Glu Arg Asn Leu Asn Met Ser Arg Val 
    210                 215                 220                 


Asp Val Tyr Thr Thr His Ser Pro Ala Gly Thr Ser Val Gln Asn Met 
225                 230                 235                 240 


Leu His Trp Ser Gln Ala Val Lys Phe Gln Lys Phe Gln Ala Phe Asp 
                245                 250                 255     


Trp Gly Ser Ser Ala Lys Asn Tyr Phe His Tyr Asn Gln Ser Tyr Pro 
            260                 265                 270         


Pro Thr Tyr Asn Val Lys Asp Met Leu Val Pro Thr Ala Val Trp Ser 
        275                 280                 285             


Gly Gly His Asp Trp Leu Ala Asp Val Tyr Asp Val Asn Ile Leu Leu 
    290                 295                 300                 


Thr Gln Ile Thr Asn Leu Val Phe His Glu Ser Ile Pro Glu Trp Glu 
305                 310                 315                 320 


His Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro Trp Arg Leu Tyr Asn 
                325                 330                 335     


Lys Ile Ile Asn Leu Met Arg Lys Tyr Gln 
            340                 345     


<210>  34
<211>  347
<212>  PRT
<213>  Homo sapiens

<400>  34

Val Glu Thr Glu Asp Gly Tyr Ile Leu Cys Leu Asn Arg Ile Pro His 
1               5                   10                  15      


Gly Arg Lys Asn His Ser Asp Lys Gly Pro Lys Pro Val Val Phe Leu 
            20                  25                  30          


Gln His Gly Leu Leu Ala Asp Ser Ser Asn Trp Val Thr Asn Leu Ala 
        35                  40                  45              


Asn Ser Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly Phe Asp Val Trp 
    50                  55                  60                  


Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys His Lys Thr Leu 
65                  70                  75                  80  


Ser Val Ser Gln Asp Glu Phe Trp Ala Phe Ser Tyr Asp Glu Met Ala 
                85                  90                  95      


Lys Tyr Asp Leu Pro Ala Ser Ile Asn Phe Ile Leu Asn Lys Thr Gly 
            100                 105                 110         


Gln Glu Gln Val Tyr Tyr Val Gly His Ser Gln Gly Thr Thr Ile Gly 
        115                 120                 125             


Phe Ile Ala Phe Ser Gln Ile Pro Glu Leu Ala Lys Arg Ile Lys Met 
    130                 135                 140                 


Phe Phe Ala Leu Gly Pro Val Ala Ser Val Ala Phe Cys Thr Ser Pro 
145                 150                 155                 160 


Met Ala Lys Leu Gly Arg Leu Pro Asp His Leu Ile Lys Asp Leu Phe 
                165                 170                 175     


Gly Asp Lys Glu Phe Leu Pro Gln Ser Ala Phe Leu Lys Trp Leu Gly 
            180                 185                 190         


Thr His Val Cys Thr His Val Ile Leu Lys Glu Leu Cys Gly Asn Leu 
        195                 200                 205             


Cys Phe Leu Leu Cys Gly Phe Asn Glu Arg Asn Leu Asn Met Ser Arg 
    210                 215                 220                 


Val Asp Val Tyr Thr Thr His Ser Pro Ala Gly Thr Ser Val Gln Asn 
225                 230                 235                 240 


Met Leu His Trp Ser Gln Ala Val Lys Phe Gln Lys Phe Gln Ala Phe 
                245                 250                 255     


Asp Trp Gly Ser Ser Ala Lys Asn Tyr Phe His Tyr Asn Gln Ser Tyr 
            260                 265                 270         


Pro Pro Thr Tyr Asn Val Lys Asp Met Leu Val Pro Thr Ala Val Trp 
        275                 280                 285             


Ser Gly Gly His Asp Trp Leu Ala Asp Val Tyr Asp Val Asn Ile Leu 
    290                 295                 300                 


Leu Thr Gln Ile Thr Asn Leu Val Phe His Glu Ser Ile Pro Glu Trp 
305                 310                 315                 320 


Glu His Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro Trp Arg Leu Tyr 
                325                 330                 335     


Asn Lys Ile Ile Asn Leu Met Arg Lys Tyr Gln 
            340                 345         


<210>  35
<211>  348
<212>  PRT
<213>  Homo sapiens

<400>  35

Leu Val Glu Thr Glu Asp Gly Tyr Ile Leu Cys Leu Asn Arg Ile Pro 
1               5                   10                  15      


His Gly Arg Lys Asn His Ser Asp Lys Gly Pro Lys Pro Val Val Phe 
            20                  25                  30          


Leu Gln His Gly Leu Leu Ala Asp Ser Ser Asn Trp Val Thr Asn Leu 
        35                  40                  45              


Ala Asn Ser Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly Phe Asp Val 
    50                  55                  60                  


Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys His Lys Thr 
65                  70                  75                  80  


Leu Ser Val Ser Gln Asp Glu Phe Trp Ala Phe Ser Tyr Asp Glu Met 
                85                  90                  95      


Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn Phe Ile Leu Asn Lys Thr 
            100                 105                 110         


Gly Gln Glu Gln Val Tyr Tyr Val Gly His Ser Gln Gly Thr Thr Ile 
        115                 120                 125             


Gly Phe Ile Ala Phe Ser Gln Ile Pro Glu Leu Ala Lys Arg Ile Lys 
    130                 135                 140                 


Met Phe Phe Ala Leu Gly Pro Val Ala Ser Val Ala Phe Cys Thr Ser 
145                 150                 155                 160 


Pro Met Ala Lys Leu Gly Arg Leu Pro Asp His Leu Ile Lys Asp Leu 
                165                 170                 175     


Phe Gly Asp Lys Glu Phe Leu Pro Gln Ser Ala Phe Leu Lys Trp Leu 
            180                 185                 190         


Gly Thr His Val Cys Thr His Val Ile Leu Lys Glu Leu Cys Gly Asn 
        195                 200                 205             


Leu Cys Phe Leu Leu Cys Gly Phe Asn Glu Arg Asn Leu Asn Met Ser 
    210                 215                 220                 


Arg Val Asp Val Tyr Thr Thr His Ser Pro Ala Gly Thr Ser Val Gln 
225                 230                 235                 240 


Asn Met Leu His Trp Ser Gln Ala Val Lys Phe Gln Lys Phe Gln Ala 
                245                 250                 255     


Phe Asp Trp Gly Ser Ser Ala Lys Asn Tyr Phe His Tyr Asn Gln Ser 
            260                 265                 270         


Tyr Pro Pro Thr Tyr Asn Val Lys Asp Met Leu Val Pro Thr Ala Val 
        275                 280                 285             


Trp Ser Gly Gly His Asp Trp Leu Ala Asp Val Tyr Asp Val Asn Ile 
    290                 295                 300                 


Leu Leu Thr Gln Ile Thr Asn Leu Val Phe His Glu Ser Ile Pro Glu 
305                 310                 315                 320 


Trp Glu His Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro Trp Arg Leu 
                325                 330                 335     


Tyr Asn Lys Ile Ile Asn Leu Met Arg Lys Tyr Gln 
            340                 345             


<210>  36
<211>  349
<212>  PRT
<213>  Homo sapiens

<400>  36

Tyr Leu Val Glu Thr Glu Asp Gly Tyr Ile Leu Cys Leu Asn Arg Ile 
1               5                   10                  15      


Pro His Gly Arg Lys Asn His Ser Asp Lys Gly Pro Lys Pro Val Val 
            20                  25                  30          


Phe Leu Gln His Gly Leu Leu Ala Asp Ser Ser Asn Trp Val Thr Asn 
        35                  40                  45              


Leu Ala Asn Ser Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly Phe Asp 
    50                  55                  60                  


Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys His Lys 
65                  70                  75                  80  


Thr Leu Ser Val Ser Gln Asp Glu Phe Trp Ala Phe Ser Tyr Asp Glu 
                85                  90                  95      


Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn Phe Ile Leu Asn Lys 
            100                 105                 110         


Thr Gly Gln Glu Gln Val Tyr Tyr Val Gly His Ser Gln Gly Thr Thr 
        115                 120                 125             


Ile Gly Phe Ile Ala Phe Ser Gln Ile Pro Glu Leu Ala Lys Arg Ile 
    130                 135                 140                 


Lys Met Phe Phe Ala Leu Gly Pro Val Ala Ser Val Ala Phe Cys Thr 
145                 150                 155                 160 


Ser Pro Met Ala Lys Leu Gly Arg Leu Pro Asp His Leu Ile Lys Asp 
                165                 170                 175     


Leu Phe Gly Asp Lys Glu Phe Leu Pro Gln Ser Ala Phe Leu Lys Trp 
            180                 185                 190         


Leu Gly Thr His Val Cys Thr His Val Ile Leu Lys Glu Leu Cys Gly 
        195                 200                 205             


Asn Leu Cys Phe Leu Leu Cys Gly Phe Asn Glu Arg Asn Leu Asn Met 
    210                 215                 220                 


Ser Arg Val Asp Val Tyr Thr Thr His Ser Pro Ala Gly Thr Ser Val 
225                 230                 235                 240 


Gln Asn Met Leu His Trp Ser Gln Ala Val Lys Phe Gln Lys Phe Gln 
                245                 250                 255     


Ala Phe Asp Trp Gly Ser Ser Ala Lys Asn Tyr Phe His Tyr Asn Gln 
            260                 265                 270         


Ser Tyr Pro Pro Thr Tyr Asn Val Lys Asp Met Leu Val Pro Thr Ala 
        275                 280                 285             


Val Trp Ser Gly Gly His Asp Trp Leu Ala Asp Val Tyr Asp Val Asn 
    290                 295                 300                 


Ile Leu Leu Thr Gln Ile Thr Asn Leu Val Phe His Glu Ser Ile Pro 
305                 310                 315                 320 


Glu Trp Glu His Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro Trp Arg 
                325                 330                 335     


Leu Tyr Asn Lys Ile Ile Asn Leu Met Arg Lys Tyr Gln 
            340                 345                 


<210>  37
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  37

Glu Tyr Leu Val Glu Thr Glu Asp Gly Tyr Ile Leu Cys Leu Asn Arg 
1               5                   10                  15      


Ile Pro His Gly Arg Lys Asn His Ser Asp Lys Gly Pro Lys Pro Val 
            20                  25                  30          


Val Phe Leu Gln His Gly Leu Leu Ala Asp Ser Ser Asn Trp Val Thr 
        35                  40                  45              


Asn Leu Ala Asn Ser Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly Phe 
    50                  55                  60                  


Asp Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys His 
65                  70                  75                  80  


Lys Thr Leu Ser Val Ser Gln Asp Glu Phe Trp Ala Phe Ser Tyr Asp 
                85                  90                  95      


Glu Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn Phe Ile Leu Asn 
            100                 105                 110         


Lys Thr Gly Gln Glu Gln Val Tyr Tyr Val Gly His Ser Gln Gly Thr 
        115                 120                 125             


Thr Ile Gly Phe Ile Ala Phe Ser Gln Ile Pro Glu Leu Ala Lys Arg 
    130                 135                 140                 


Ile Lys Met Phe Phe Ala Leu Gly Pro Val Ala Ser Val Ala Phe Cys 
145                 150                 155                 160 


Thr Ser Pro Met Ala Lys Leu Gly Arg Leu Pro Asp His Leu Ile Lys 
                165                 170                 175     


Asp Leu Phe Gly Asp Lys Glu Phe Leu Pro Gln Ser Ala Phe Leu Lys 
            180                 185                 190         


Trp Leu Gly Thr His Val Cys Thr His Val Ile Leu Lys Glu Leu Cys 
        195                 200                 205             


Gly Asn Leu Cys Phe Leu Leu Cys Gly Phe Asn Glu Arg Asn Leu Asn 
    210                 215                 220                 


Met Ser Arg Val Asp Val Tyr Thr Thr His Ser Pro Ala Gly Thr Ser 
225                 230                 235                 240 


Val Gln Asn Met Leu His Trp Ser Gln Ala Val Lys Phe Gln Lys Phe 
                245                 250                 255     


Gln Ala Phe Asp Trp Gly Ser Ser Ala Lys Asn Tyr Phe His Tyr Asn 
            260                 265                 270         


Gln Ser Tyr Pro Pro Thr Tyr Asn Val Lys Asp Met Leu Val Pro Thr 
        275                 280                 285             


Ala Val Trp Ser Gly Gly His Asp Trp Leu Ala Asp Val Tyr Asp Val 
    290                 295                 300                 


Asn Ile Leu Leu Thr Gln Ile Thr Asn Leu Val Phe His Glu Ser Ile 
305                 310                 315                 320 


Pro Glu Trp Glu His Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro Trp 
                325                 330                 335     


Arg Leu Tyr Asn Lys Ile Ile Asn Leu Met Arg Lys Tyr Gln 
            340                 345                 350 


<210>  38
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  38

Glu Glu Tyr Leu Val Glu Thr Glu Asp Gly Tyr Ile Leu Cys Leu Asn 
1               5                   10                  15      


Arg Ile Pro His Gly Arg Lys Asn His Ser Asp Lys Gly Pro Lys Pro 
            20                  25                  30          


Val Val Phe Leu Gln His Gly Leu Leu Ala Asp Ser Ser Asn Trp Val 
        35                  40                  45              


Thr Asn Leu Ala Asn Ser Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly 
    50                  55                  60                  


Phe Asp Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys 
65                  70                  75                  80  


His Lys Thr Leu Ser Val Ser Gln Asp Glu Phe Trp Ala Phe Ser Tyr 
                85                  90                  95      


Asp Glu Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn Phe Ile Leu 
            100                 105                 110         


Asn Lys Thr Gly Gln Glu Gln Val Tyr Tyr Val Gly His Ser Gln Gly 
        115                 120                 125             


Thr Thr Ile Gly Phe Ile Ala Phe Ser Gln Ile Pro Glu Leu Ala Lys 
    130                 135                 140                 


Arg Ile Lys Met Phe Phe Ala Leu Gly Pro Val Ala Ser Val Ala Phe 
145                 150                 155                 160 


Cys Thr Ser Pro Met Ala Lys Leu Gly Arg Leu Pro Asp His Leu Ile 
                165                 170                 175     


Lys Asp Leu Phe Gly Asp Lys Glu Phe Leu Pro Gln Ser Ala Phe Leu 
            180                 185                 190         


Lys Trp Leu Gly Thr His Val Cys Thr His Val Ile Leu Lys Glu Leu 
        195                 200                 205             


Cys Gly Asn Leu Cys Phe Leu Leu Cys Gly Phe Asn Glu Arg Asn Leu 
    210                 215                 220                 


Asn Met Ser Arg Val Asp Val Tyr Thr Thr His Ser Pro Ala Gly Thr 
225                 230                 235                 240 


Ser Val Gln Asn Met Leu His Trp Ser Gln Ala Val Lys Phe Gln Lys 
                245                 250                 255     


Phe Gln Ala Phe Asp Trp Gly Ser Ser Ala Lys Asn Tyr Phe His Tyr 
            260                 265                 270         


Asn Gln Ser Tyr Pro Pro Thr Tyr Asn Val Lys Asp Met Leu Val Pro 
        275                 280                 285             


Thr Ala Val Trp Ser Gly Gly His Asp Trp Leu Ala Asp Val Tyr Asp 
    290                 295                 300                 


Val Asn Ile Leu Leu Thr Gln Ile Thr Asn Leu Val Phe His Glu Ser 
305                 310                 315                 320 


Ile Pro Glu Trp Glu His Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro 
                325                 330                 335     


Trp Arg Leu Tyr Asn Lys Ile Ile Asn Leu Met Arg Lys Tyr Gln 
            340                 345                 350     


<210>  39
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  39

Ser Glu Glu Tyr Leu Val Glu Thr Glu Asp Gly Tyr Ile Leu Cys Leu 
1               5                   10                  15      


Asn Arg Ile Pro His Gly Arg Lys Asn His Ser Asp Lys Gly Pro Lys 
            20                  25                  30          


Pro Val Val Phe Leu Gln His Gly Leu Leu Ala Asp Ser Ser Asn Trp 
        35                  40                  45              


Val Thr Asn Leu Ala Asn Ser Ser Leu Gly Phe Ile Leu Ala Asp Ala 
    50                  55                  60                  


Gly Phe Asp Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg 
65                  70                  75                  80  


Lys His Lys Thr Leu Ser Val Ser Gln Asp Glu Phe Trp Ala Phe Ser 
                85                  90                  95      


Tyr Asp Glu Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn Phe Ile 
            100                 105                 110         


Leu Asn Lys Thr Gly Gln Glu Gln Val Tyr Tyr Val Gly His Ser Gln 
        115                 120                 125             


Gly Thr Thr Ile Gly Phe Ile Ala Phe Ser Gln Ile Pro Glu Leu Ala 
    130                 135                 140                 


Lys Arg Ile Lys Met Phe Phe Ala Leu Gly Pro Val Ala Ser Val Ala 
145                 150                 155                 160 


Phe Cys Thr Ser Pro Met Ala Lys Leu Gly Arg Leu Pro Asp His Leu 
                165                 170                 175     


Ile Lys Asp Leu Phe Gly Asp Lys Glu Phe Leu Pro Gln Ser Ala Phe 
            180                 185                 190         


Leu Lys Trp Leu Gly Thr His Val Cys Thr His Val Ile Leu Lys Glu 
        195                 200                 205             


Leu Cys Gly Asn Leu Cys Phe Leu Leu Cys Gly Phe Asn Glu Arg Asn 
    210                 215                 220                 


Leu Asn Met Ser Arg Val Asp Val Tyr Thr Thr His Ser Pro Ala Gly 
225                 230                 235                 240 


Thr Ser Val Gln Asn Met Leu His Trp Ser Gln Ala Val Lys Phe Gln 
                245                 250                 255     


Lys Phe Gln Ala Phe Asp Trp Gly Ser Ser Ala Lys Asn Tyr Phe His 
            260                 265                 270         


Tyr Asn Gln Ser Tyr Pro Pro Thr Tyr Asn Val Lys Asp Met Leu Val 
        275                 280                 285             


Pro Thr Ala Val Trp Ser Gly Gly His Asp Trp Leu Ala Asp Val Tyr 
    290                 295                 300                 


Asp Val Asn Ile Leu Leu Thr Gln Ile Thr Asn Leu Val Phe His Glu 
305                 310                 315                 320 


Ser Ile Pro Glu Trp Glu His Leu Asp Phe Ile Trp Gly Leu Asp Ala 
                325                 330                 335     


Pro Trp Arg Leu Tyr Asn Lys Ile Ile Asn Leu Met Arg Lys Tyr Gln 
            340                 345                 350         


<210>  40
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  40

Pro Ser Glu Glu Tyr Leu Val Glu Thr Glu Asp Gly Tyr Ile Leu Cys 
1               5                   10                  15      


Leu Asn Arg Ile Pro His Gly Arg Lys Asn His Ser Asp Lys Gly Pro 
            20                  25                  30          


Lys Pro Val Val Phe Leu Gln His Gly Leu Leu Ala Asp Ser Ser Asn 
        35                  40                  45              


Trp Val Thr Asn Leu Ala Asn Ser Ser Leu Gly Phe Ile Leu Ala Asp 
    50                  55                  60                  


Ala Gly Phe Asp Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser 
65                  70                  75                  80  


Arg Lys His Lys Thr Leu Ser Val Ser Gln Asp Glu Phe Trp Ala Phe 
                85                  90                  95      


Ser Tyr Asp Glu Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn Phe 
            100                 105                 110         


Ile Leu Asn Lys Thr Gly Gln Glu Gln Val Tyr Tyr Val Gly His Ser 
        115                 120                 125             


Gln Gly Thr Thr Ile Gly Phe Ile Ala Phe Ser Gln Ile Pro Glu Leu 
    130                 135                 140                 


Ala Lys Arg Ile Lys Met Phe Phe Ala Leu Gly Pro Val Ala Ser Val 
145                 150                 155                 160 


Ala Phe Cys Thr Ser Pro Met Ala Lys Leu Gly Arg Leu Pro Asp His 
                165                 170                 175     


Leu Ile Lys Asp Leu Phe Gly Asp Lys Glu Phe Leu Pro Gln Ser Ala 
            180                 185                 190         


Phe Leu Lys Trp Leu Gly Thr His Val Cys Thr His Val Ile Leu Lys 
        195                 200                 205             


Glu Leu Cys Gly Asn Leu Cys Phe Leu Leu Cys Gly Phe Asn Glu Arg 
    210                 215                 220                 


Asn Leu Asn Met Ser Arg Val Asp Val Tyr Thr Thr His Ser Pro Ala 
225                 230                 235                 240 


Gly Thr Ser Val Gln Asn Met Leu His Trp Ser Gln Ala Val Lys Phe 
                245                 250                 255     


Gln Lys Phe Gln Ala Phe Asp Trp Gly Ser Ser Ala Lys Asn Tyr Phe 
            260                 265                 270         


His Tyr Asn Gln Ser Tyr Pro Pro Thr Tyr Asn Val Lys Asp Met Leu 
        275                 280                 285             


Val Pro Thr Ala Val Trp Ser Gly Gly His Asp Trp Leu Ala Asp Val 
    290                 295                 300                 


Tyr Asp Val Asn Ile Leu Leu Thr Gln Ile Thr Asn Leu Val Phe His 
305                 310                 315                 320 


Glu Ser Ile Pro Glu Trp Glu His Leu Asp Phe Ile Trp Gly Leu Asp 
                325                 330                 335     


Ala Pro Trp Arg Leu Tyr Asn Lys Ile Ile Asn Leu Met Arg Lys Tyr 
            340                 345                 350         


Gln 
    


<210>  41
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  41

Phe Pro Ser Glu Glu Tyr Leu Val Glu Thr Glu Asp Gly Tyr Ile Leu 
1               5                   10                  15      


Cys Leu Asn Arg Ile Pro His Gly Arg Lys Asn His Ser Asp Lys Gly 
            20                  25                  30          


Pro Lys Pro Val Val Phe Leu Gln His Gly Leu Leu Ala Asp Ser Ser 
        35                  40                  45              


Asn Trp Val Thr Asn Leu Ala Asn Ser Ser Leu Gly Phe Ile Leu Ala 
    50                  55                  60                  


Asp Ala Gly Phe Asp Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp 
65                  70                  75                  80  


Ser Arg Lys His Lys Thr Leu Ser Val Ser Gln Asp Glu Phe Trp Ala 
                85                  90                  95      


Phe Ser Tyr Asp Glu Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn 
            100                 105                 110         


Phe Ile Leu Asn Lys Thr Gly Gln Glu Gln Val Tyr Tyr Val Gly His 
        115                 120                 125             


Ser Gln Gly Thr Thr Ile Gly Phe Ile Ala Phe Ser Gln Ile Pro Glu 
    130                 135                 140                 


Leu Ala Lys Arg Ile Lys Met Phe Phe Ala Leu Gly Pro Val Ala Ser 
145                 150                 155                 160 


Val Ala Phe Cys Thr Ser Pro Met Ala Lys Leu Gly Arg Leu Pro Asp 
                165                 170                 175     


His Leu Ile Lys Asp Leu Phe Gly Asp Lys Glu Phe Leu Pro Gln Ser 
            180                 185                 190         


Ala Phe Leu Lys Trp Leu Gly Thr His Val Cys Thr His Val Ile Leu 
        195                 200                 205             


Lys Glu Leu Cys Gly Asn Leu Cys Phe Leu Leu Cys Gly Phe Asn Glu 
    210                 215                 220                 


Arg Asn Leu Asn Met Ser Arg Val Asp Val Tyr Thr Thr His Ser Pro 
225                 230                 235                 240 


Ala Gly Thr Ser Val Gln Asn Met Leu His Trp Ser Gln Ala Val Lys 
                245                 250                 255     


Phe Gln Lys Phe Gln Ala Phe Asp Trp Gly Ser Ser Ala Lys Asn Tyr 
            260                 265                 270         


Phe His Tyr Asn Gln Ser Tyr Pro Pro Thr Tyr Asn Val Lys Asp Met 
        275                 280                 285             


Leu Val Pro Thr Ala Val Trp Ser Gly Gly His Asp Trp Leu Ala Asp 
    290                 295                 300                 


Val Tyr Asp Val Asn Ile Leu Leu Thr Gln Ile Thr Asn Leu Val Phe 
305                 310                 315                 320 


His Glu Ser Ile Pro Glu Trp Glu His Leu Asp Phe Ile Trp Gly Leu 
                325                 330                 335     


Asp Ala Pro Trp Arg Leu Tyr Asn Lys Ile Ile Asn Leu Met Arg Lys 
            340                 345                 350         


Tyr Gln 
        


<210>  42
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  42

Gly Phe Pro Ser Glu Glu Tyr Leu Val Glu Thr Glu Asp Gly Tyr Ile 
1               5                   10                  15      


Leu Cys Leu Asn Arg Ile Pro His Gly Arg Lys Asn His Ser Asp Lys 
            20                  25                  30          


Gly Pro Lys Pro Val Val Phe Leu Gln His Gly Leu Leu Ala Asp Ser 
        35                  40                  45              


Ser Asn Trp Val Thr Asn Leu Ala Asn Ser Ser Leu Gly Phe Ile Leu 
    50                  55                  60                  


Ala Asp Ala Gly Phe Asp Val Trp Met Gly Asn Ser Arg Gly Asn Thr 
65                  70                  75                  80  


Trp Ser Arg Lys His Lys Thr Leu Ser Val Ser Gln Asp Glu Phe Trp 
                85                  90                  95      


Ala Phe Ser Tyr Asp Glu Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile 
            100                 105                 110         


Asn Phe Ile Leu Asn Lys Thr Gly Gln Glu Gln Val Tyr Tyr Val Gly 
        115                 120                 125             


His Ser Gln Gly Thr Thr Ile Gly Phe Ile Ala Phe Ser Gln Ile Pro 
    130                 135                 140                 


Glu Leu Ala Lys Arg Ile Lys Met Phe Phe Ala Leu Gly Pro Val Ala 
145                 150                 155                 160 


Ser Val Ala Phe Cys Thr Ser Pro Met Ala Lys Leu Gly Arg Leu Pro 
                165                 170                 175     


Asp His Leu Ile Lys Asp Leu Phe Gly Asp Lys Glu Phe Leu Pro Gln 
            180                 185                 190         


Ser Ala Phe Leu Lys Trp Leu Gly Thr His Val Cys Thr His Val Ile 
        195                 200                 205             


Leu Lys Glu Leu Cys Gly Asn Leu Cys Phe Leu Leu Cys Gly Phe Asn 
    210                 215                 220                 


Glu Arg Asn Leu Asn Met Ser Arg Val Asp Val Tyr Thr Thr His Ser 
225                 230                 235                 240 


Pro Ala Gly Thr Ser Val Gln Asn Met Leu His Trp Ser Gln Ala Val 
                245                 250                 255     


Lys Phe Gln Lys Phe Gln Ala Phe Asp Trp Gly Ser Ser Ala Lys Asn 
            260                 265                 270         


Tyr Phe His Tyr Asn Gln Ser Tyr Pro Pro Thr Tyr Asn Val Lys Asp 
        275                 280                 285             


Met Leu Val Pro Thr Ala Val Trp Ser Gly Gly His Asp Trp Leu Ala 
    290                 295                 300                 


Asp Val Tyr Asp Val Asn Ile Leu Leu Thr Gln Ile Thr Asn Leu Val 
305                 310                 315                 320 


Phe His Glu Ser Ile Pro Glu Trp Glu His Leu Asp Phe Ile Trp Gly 
                325                 330                 335     


Leu Asp Ala Pro Trp Arg Leu Tyr Asn Lys Ile Ile Asn Leu Met Arg 
            340                 345                 350         


Lys Tyr Gln 
        355 


<210>  43
<211>  356
<212>  PRT
<213>  Homo sapiens

<400>  43

Trp Gly Phe Pro Ser Glu Glu Tyr Leu Val Glu Thr Glu Asp Gly Tyr 
1               5                   10                  15      


Ile Leu Cys Leu Asn Arg Ile Pro His Gly Arg Lys Asn His Ser Asp 
            20                  25                  30          


Lys Gly Pro Lys Pro Val Val Phe Leu Gln His Gly Leu Leu Ala Asp 
        35                  40                  45              


Ser Ser Asn Trp Val Thr Asn Leu Ala Asn Ser Ser Leu Gly Phe Ile 
    50                  55                  60                  


Leu Ala Asp Ala Gly Phe Asp Val Trp Met Gly Asn Ser Arg Gly Asn 
65                  70                  75                  80  


Thr Trp Ser Arg Lys His Lys Thr Leu Ser Val Ser Gln Asp Glu Phe 
                85                  90                  95      


Trp Ala Phe Ser Tyr Asp Glu Met Ala Lys Tyr Asp Leu Pro Ala Ser 
            100                 105                 110         


Ile Asn Phe Ile Leu Asn Lys Thr Gly Gln Glu Gln Val Tyr Tyr Val 
        115                 120                 125             


Gly His Ser Gln Gly Thr Thr Ile Gly Phe Ile Ala Phe Ser Gln Ile 
    130                 135                 140                 


Pro Glu Leu Ala Lys Arg Ile Lys Met Phe Phe Ala Leu Gly Pro Val 
145                 150                 155                 160 


Ala Ser Val Ala Phe Cys Thr Ser Pro Met Ala Lys Leu Gly Arg Leu 
                165                 170                 175     


Pro Asp His Leu Ile Lys Asp Leu Phe Gly Asp Lys Glu Phe Leu Pro 
            180                 185                 190         


Gln Ser Ala Phe Leu Lys Trp Leu Gly Thr His Val Cys Thr His Val 
        195                 200                 205             


Ile Leu Lys Glu Leu Cys Gly Asn Leu Cys Phe Leu Leu Cys Gly Phe 
    210                 215                 220                 


Asn Glu Arg Asn Leu Asn Met Ser Arg Val Asp Val Tyr Thr Thr His 
225                 230                 235                 240 


Ser Pro Ala Gly Thr Ser Val Gln Asn Met Leu His Trp Ser Gln Ala 
                245                 250                 255     


Val Lys Phe Gln Lys Phe Gln Ala Phe Asp Trp Gly Ser Ser Ala Lys 
            260                 265                 270         


Asn Tyr Phe His Tyr Asn Gln Ser Tyr Pro Pro Thr Tyr Asn Val Lys 
        275                 280                 285             


Asp Met Leu Val Pro Thr Ala Val Trp Ser Gly Gly His Asp Trp Leu 
    290                 295                 300                 


Ala Asp Val Tyr Asp Val Asn Ile Leu Leu Thr Gln Ile Thr Asn Leu 
305                 310                 315                 320 


Val Phe His Glu Ser Ile Pro Glu Trp Glu His Leu Asp Phe Ile Trp 
                325                 330                 335     


Gly Leu Asp Ala Pro Trp Arg Leu Tyr Asn Lys Ile Ile Asn Leu Met 
            340                 345                 350         


Arg Lys Tyr Gln 
        355     


<210>  44
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  44

Tyr Trp Gly Phe Pro Ser Glu Glu Tyr Leu Val Glu Thr Glu Asp Gly 
1               5                   10                  15      


Tyr Ile Leu Cys Leu Asn Arg Ile Pro His Gly Arg Lys Asn His Ser 
            20                  25                  30          


Asp Lys Gly Pro Lys Pro Val Val Phe Leu Gln His Gly Leu Leu Ala 
        35                  40                  45              


Asp Ser Ser Asn Trp Val Thr Asn Leu Ala Asn Ser Ser Leu Gly Phe 
    50                  55                  60                  


Ile Leu Ala Asp Ala Gly Phe Asp Val Trp Met Gly Asn Ser Arg Gly 
65                  70                  75                  80  


Asn Thr Trp Ser Arg Lys His Lys Thr Leu Ser Val Ser Gln Asp Glu 
                85                  90                  95      


Phe Trp Ala Phe Ser Tyr Asp Glu Met Ala Lys Tyr Asp Leu Pro Ala 
            100                 105                 110         


Ser Ile Asn Phe Ile Leu Asn Lys Thr Gly Gln Glu Gln Val Tyr Tyr 
        115                 120                 125             


Val Gly His Ser Gln Gly Thr Thr Ile Gly Phe Ile Ala Phe Ser Gln 
    130                 135                 140                 


Ile Pro Glu Leu Ala Lys Arg Ile Lys Met Phe Phe Ala Leu Gly Pro 
145                 150                 155                 160 


Val Ala Ser Val Ala Phe Cys Thr Ser Pro Met Ala Lys Leu Gly Arg 
                165                 170                 175     


Leu Pro Asp His Leu Ile Lys Asp Leu Phe Gly Asp Lys Glu Phe Leu 
            180                 185                 190         


Pro Gln Ser Ala Phe Leu Lys Trp Leu Gly Thr His Val Cys Thr His 
        195                 200                 205             


Val Ile Leu Lys Glu Leu Cys Gly Asn Leu Cys Phe Leu Leu Cys Gly 
    210                 215                 220                 


Phe Asn Glu Arg Asn Leu Asn Met Ser Arg Val Asp Val Tyr Thr Thr 
225                 230                 235                 240 


His Ser Pro Ala Gly Thr Ser Val Gln Asn Met Leu His Trp Ser Gln 
                245                 250                 255     


Ala Val Lys Phe Gln Lys Phe Gln Ala Phe Asp Trp Gly Ser Ser Ala 
            260                 265                 270         


Lys Asn Tyr Phe His Tyr Asn Gln Ser Tyr Pro Pro Thr Tyr Asn Val 
        275                 280                 285             


Lys Asp Met Leu Val Pro Thr Ala Val Trp Ser Gly Gly His Asp Trp 
    290                 295                 300                 


Leu Ala Asp Val Tyr Asp Val Asn Ile Leu Leu Thr Gln Ile Thr Asn 
305                 310                 315                 320 


Leu Val Phe His Glu Ser Ile Pro Glu Trp Glu His Leu Asp Phe Ile 
                325                 330                 335     


Trp Gly Leu Asp Ala Pro Trp Arg Leu Tyr Asn Lys Ile Ile Asn Leu 
            340                 345                 350         


Met Arg Lys Tyr Gln 
        355         


<210>  45
<211>  358
<212>  PRT
<213>  Homo sapiens

<400>  45

Ser Tyr Trp Gly Phe Pro Ser Glu Glu Tyr Leu Val Glu Thr Glu Asp 
1               5                   10                  15      


Gly Tyr Ile Leu Cys Leu Asn Arg Ile Pro His Gly Arg Lys Asn His 
            20                  25                  30          


Ser Asp Lys Gly Pro Lys Pro Val Val Phe Leu Gln His Gly Leu Leu 
        35                  40                  45              


Ala Asp Ser Ser Asn Trp Val Thr Asn Leu Ala Asn Ser Ser Leu Gly 
    50                  55                  60                  


Phe Ile Leu Ala Asp Ala Gly Phe Asp Val Trp Met Gly Asn Ser Arg 
65                  70                  75                  80  


Gly Asn Thr Trp Ser Arg Lys His Lys Thr Leu Ser Val Ser Gln Asp 
                85                  90                  95      


Glu Phe Trp Ala Phe Ser Tyr Asp Glu Met Ala Lys Tyr Asp Leu Pro 
            100                 105                 110         


Ala Ser Ile Asn Phe Ile Leu Asn Lys Thr Gly Gln Glu Gln Val Tyr 
        115                 120                 125             


Tyr Val Gly His Ser Gln Gly Thr Thr Ile Gly Phe Ile Ala Phe Ser 
    130                 135                 140                 


Gln Ile Pro Glu Leu Ala Lys Arg Ile Lys Met Phe Phe Ala Leu Gly 
145                 150                 155                 160 


Pro Val Ala Ser Val Ala Phe Cys Thr Ser Pro Met Ala Lys Leu Gly 
                165                 170                 175     


Arg Leu Pro Asp His Leu Ile Lys Asp Leu Phe Gly Asp Lys Glu Phe 
            180                 185                 190         


Leu Pro Gln Ser Ala Phe Leu Lys Trp Leu Gly Thr His Val Cys Thr 
        195                 200                 205             


His Val Ile Leu Lys Glu Leu Cys Gly Asn Leu Cys Phe Leu Leu Cys 
    210                 215                 220                 


Gly Phe Asn Glu Arg Asn Leu Asn Met Ser Arg Val Asp Val Tyr Thr 
225                 230                 235                 240 


Thr His Ser Pro Ala Gly Thr Ser Val Gln Asn Met Leu His Trp Ser 
                245                 250                 255     


Gln Ala Val Lys Phe Gln Lys Phe Gln Ala Phe Asp Trp Gly Ser Ser 
            260                 265                 270         


Ala Lys Asn Tyr Phe His Tyr Asn Gln Ser Tyr Pro Pro Thr Tyr Asn 
        275                 280                 285             


Val Lys Asp Met Leu Val Pro Thr Ala Val Trp Ser Gly Gly His Asp 
    290                 295                 300                 


Trp Leu Ala Asp Val Tyr Asp Val Asn Ile Leu Leu Thr Gln Ile Thr 
305                 310                 315                 320 


Asn Leu Val Phe His Glu Ser Ile Pro Glu Trp Glu His Leu Asp Phe 
                325                 330                 335     


Ile Trp Gly Leu Asp Ala Pro Trp Arg Leu Tyr Asn Lys Ile Ile Asn 
            340                 345                 350         


Leu Met Arg Lys Tyr Gln 
        355             


<210>  46
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  46

Ile Ser Tyr Trp Gly Phe Pro Ser Glu Glu Tyr Leu Val Glu Thr Glu 
1               5                   10                  15      


Asp Gly Tyr Ile Leu Cys Leu Asn Arg Ile Pro His Gly Arg Lys Asn 
            20                  25                  30          


His Ser Asp Lys Gly Pro Lys Pro Val Val Phe Leu Gln His Gly Leu 
        35                  40                  45              


Leu Ala Asp Ser Ser Asn Trp Val Thr Asn Leu Ala Asn Ser Ser Leu 
    50                  55                  60                  


Gly Phe Ile Leu Ala Asp Ala Gly Phe Asp Val Trp Met Gly Asn Ser 
65                  70                  75                  80  


Arg Gly Asn Thr Trp Ser Arg Lys His Lys Thr Leu Ser Val Ser Gln 
                85                  90                  95      


Asp Glu Phe Trp Ala Phe Ser Tyr Asp Glu Met Ala Lys Tyr Asp Leu 
            100                 105                 110         


Pro Ala Ser Ile Asn Phe Ile Leu Asn Lys Thr Gly Gln Glu Gln Val 
        115                 120                 125             


Tyr Tyr Val Gly His Ser Gln Gly Thr Thr Ile Gly Phe Ile Ala Phe 
    130                 135                 140                 


Ser Gln Ile Pro Glu Leu Ala Lys Arg Ile Lys Met Phe Phe Ala Leu 
145                 150                 155                 160 


Gly Pro Val Ala Ser Val Ala Phe Cys Thr Ser Pro Met Ala Lys Leu 
                165                 170                 175     


Gly Arg Leu Pro Asp His Leu Ile Lys Asp Leu Phe Gly Asp Lys Glu 
            180                 185                 190         


Phe Leu Pro Gln Ser Ala Phe Leu Lys Trp Leu Gly Thr His Val Cys 
        195                 200                 205             


Thr His Val Ile Leu Lys Glu Leu Cys Gly Asn Leu Cys Phe Leu Leu 
    210                 215                 220                 


Cys Gly Phe Asn Glu Arg Asn Leu Asn Met Ser Arg Val Asp Val Tyr 
225                 230                 235                 240 


Thr Thr His Ser Pro Ala Gly Thr Ser Val Gln Asn Met Leu His Trp 
                245                 250                 255     


Ser Gln Ala Val Lys Phe Gln Lys Phe Gln Ala Phe Asp Trp Gly Ser 
            260                 265                 270         


Ser Ala Lys Asn Tyr Phe His Tyr Asn Gln Ser Tyr Pro Pro Thr Tyr 
        275                 280                 285             


Asn Val Lys Asp Met Leu Val Pro Thr Ala Val Trp Ser Gly Gly His 
    290                 295                 300                 


Asp Trp Leu Ala Asp Val Tyr Asp Val Asn Ile Leu Leu Thr Gln Ile 
305                 310                 315                 320 


Thr Asn Leu Val Phe His Glu Ser Ile Pro Glu Trp Glu His Leu Asp 
                325                 330                 335     


Phe Ile Trp Gly Leu Asp Ala Pro Trp Arg Leu Tyr Asn Lys Ile Ile 
            340                 345                 350         


Asn Leu Met Arg Lys Tyr Gln 
        355                 


<210>  47
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  47

Ile Ile Ser Tyr Trp Gly Phe Pro Ser Glu Glu Tyr Leu Val Glu Thr 
1               5                   10                  15      


Glu Asp Gly Tyr Ile Leu Cys Leu Asn Arg Ile Pro His Gly Arg Lys 
            20                  25                  30          


Asn His Ser Asp Lys Gly Pro Lys Pro Val Val Phe Leu Gln His Gly 
        35                  40                  45              


Leu Leu Ala Asp Ser Ser Asn Trp Val Thr Asn Leu Ala Asn Ser Ser 
    50                  55                  60                  


Leu Gly Phe Ile Leu Ala Asp Ala Gly Phe Asp Val Trp Met Gly Asn 
65                  70                  75                  80  


Ser Arg Gly Asn Thr Trp Ser Arg Lys His Lys Thr Leu Ser Val Ser 
                85                  90                  95      


Gln Asp Glu Phe Trp Ala Phe Ser Tyr Asp Glu Met Ala Lys Tyr Asp 
            100                 105                 110         


Leu Pro Ala Ser Ile Asn Phe Ile Leu Asn Lys Thr Gly Gln Glu Gln 
        115                 120                 125             


Val Tyr Tyr Val Gly His Ser Gln Gly Thr Thr Ile Gly Phe Ile Ala 
    130                 135                 140                 


Phe Ser Gln Ile Pro Glu Leu Ala Lys Arg Ile Lys Met Phe Phe Ala 
145                 150                 155                 160 


Leu Gly Pro Val Ala Ser Val Ala Phe Cys Thr Ser Pro Met Ala Lys 
                165                 170                 175     


Leu Gly Arg Leu Pro Asp His Leu Ile Lys Asp Leu Phe Gly Asp Lys 
            180                 185                 190         


Glu Phe Leu Pro Gln Ser Ala Phe Leu Lys Trp Leu Gly Thr His Val 
        195                 200                 205             


Cys Thr His Val Ile Leu Lys Glu Leu Cys Gly Asn Leu Cys Phe Leu 
    210                 215                 220                 


Leu Cys Gly Phe Asn Glu Arg Asn Leu Asn Met Ser Arg Val Asp Val 
225                 230                 235                 240 


Tyr Thr Thr His Ser Pro Ala Gly Thr Ser Val Gln Asn Met Leu His 
                245                 250                 255     


Trp Ser Gln Ala Val Lys Phe Gln Lys Phe Gln Ala Phe Asp Trp Gly 
            260                 265                 270         


Ser Ser Ala Lys Asn Tyr Phe His Tyr Asn Gln Ser Tyr Pro Pro Thr 
        275                 280                 285             


Tyr Asn Val Lys Asp Met Leu Val Pro Thr Ala Val Trp Ser Gly Gly 
    290                 295                 300                 


His Asp Trp Leu Ala Asp Val Tyr Asp Val Asn Ile Leu Leu Thr Gln 
305                 310                 315                 320 


Ile Thr Asn Leu Val Phe His Glu Ser Ile Pro Glu Trp Glu His Leu 
                325                 330                 335     


Asp Phe Ile Trp Gly Leu Asp Ala Pro Trp Arg Leu Tyr Asn Lys Ile 
            340                 345                 350         


Ile Asn Leu Met Arg Lys Tyr Gln 
        355                 360 


<210>  48
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  48

Glu Ile Ile Ser Tyr Trp Gly Phe Pro Ser Glu Glu Tyr Leu Val Glu 
1               5                   10                  15      


Thr Glu Asp Gly Tyr Ile Leu Cys Leu Asn Arg Ile Pro His Gly Arg 
            20                  25                  30          


Lys Asn His Ser Asp Lys Gly Pro Lys Pro Val Val Phe Leu Gln His 
        35                  40                  45              


Gly Leu Leu Ala Asp Ser Ser Asn Trp Val Thr Asn Leu Ala Asn Ser 
    50                  55                  60                  


Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly Phe Asp Val Trp Met Gly 
65                  70                  75                  80  


Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys His Lys Thr Leu Ser Val 
                85                  90                  95      


Ser Gln Asp Glu Phe Trp Ala Phe Ser Tyr Asp Glu Met Ala Lys Tyr 
            100                 105                 110         


Asp Leu Pro Ala Ser Ile Asn Phe Ile Leu Asn Lys Thr Gly Gln Glu 
        115                 120                 125             


Gln Val Tyr Tyr Val Gly His Ser Gln Gly Thr Thr Ile Gly Phe Ile 
    130                 135                 140                 


Ala Phe Ser Gln Ile Pro Glu Leu Ala Lys Arg Ile Lys Met Phe Phe 
145                 150                 155                 160 


Ala Leu Gly Pro Val Ala Ser Val Ala Phe Cys Thr Ser Pro Met Ala 
                165                 170                 175     


Lys Leu Gly Arg Leu Pro Asp His Leu Ile Lys Asp Leu Phe Gly Asp 
            180                 185                 190         


Lys Glu Phe Leu Pro Gln Ser Ala Phe Leu Lys Trp Leu Gly Thr His 
        195                 200                 205             


Val Cys Thr His Val Ile Leu Lys Glu Leu Cys Gly Asn Leu Cys Phe 
    210                 215                 220                 


Leu Leu Cys Gly Phe Asn Glu Arg Asn Leu Asn Met Ser Arg Val Asp 
225                 230                 235                 240 


Val Tyr Thr Thr His Ser Pro Ala Gly Thr Ser Val Gln Asn Met Leu 
                245                 250                 255     


His Trp Ser Gln Ala Val Lys Phe Gln Lys Phe Gln Ala Phe Asp Trp 
            260                 265                 270         


Gly Ser Ser Ala Lys Asn Tyr Phe His Tyr Asn Gln Ser Tyr Pro Pro 
        275                 280                 285             


Thr Tyr Asn Val Lys Asp Met Leu Val Pro Thr Ala Val Trp Ser Gly 
    290                 295                 300                 


Gly His Asp Trp Leu Ala Asp Val Tyr Asp Val Asn Ile Leu Leu Thr 
305                 310                 315                 320 


Gln Ile Thr Asn Leu Val Phe His Glu Ser Ile Pro Glu Trp Glu His 
                325                 330                 335     


Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro Trp Arg Leu Tyr Asn Lys 
            340                 345                 350         


Ile Ile Asn Leu Met Arg Lys Tyr Gln 
        355                 360     


<210>  49
<211>  362
<212>  PRT
<213>  Homo sapiens

<400>  49

Ser Glu Ile Ile Ser Tyr Trp Gly Phe Pro Ser Glu Glu Tyr Leu Val 
1               5                   10                  15      


Glu Thr Glu Asp Gly Tyr Ile Leu Cys Leu Asn Arg Ile Pro His Gly 
            20                  25                  30          


Arg Lys Asn His Ser Asp Lys Gly Pro Lys Pro Val Val Phe Leu Gln 
        35                  40                  45              


His Gly Leu Leu Ala Asp Ser Ser Asn Trp Val Thr Asn Leu Ala Asn 
    50                  55                  60                  


Ser Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly Phe Asp Val Trp Met 
65                  70                  75                  80  


Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys His Lys Thr Leu Ser 
                85                  90                  95      


Val Ser Gln Asp Glu Phe Trp Ala Phe Ser Tyr Asp Glu Met Ala Lys 
            100                 105                 110         


Tyr Asp Leu Pro Ala Ser Ile Asn Phe Ile Leu Asn Lys Thr Gly Gln 
        115                 120                 125             


Glu Gln Val Tyr Tyr Val Gly His Ser Gln Gly Thr Thr Ile Gly Phe 
    130                 135                 140                 


Ile Ala Phe Ser Gln Ile Pro Glu Leu Ala Lys Arg Ile Lys Met Phe 
145                 150                 155                 160 


Phe Ala Leu Gly Pro Val Ala Ser Val Ala Phe Cys Thr Ser Pro Met 
                165                 170                 175     


Ala Lys Leu Gly Arg Leu Pro Asp His Leu Ile Lys Asp Leu Phe Gly 
            180                 185                 190         


Asp Lys Glu Phe Leu Pro Gln Ser Ala Phe Leu Lys Trp Leu Gly Thr 
        195                 200                 205             


His Val Cys Thr His Val Ile Leu Lys Glu Leu Cys Gly Asn Leu Cys 
    210                 215                 220                 


Phe Leu Leu Cys Gly Phe Asn Glu Arg Asn Leu Asn Met Ser Arg Val 
225                 230                 235                 240 


Asp Val Tyr Thr Thr His Ser Pro Ala Gly Thr Ser Val Gln Asn Met 
                245                 250                 255     


Leu His Trp Ser Gln Ala Val Lys Phe Gln Lys Phe Gln Ala Phe Asp 
            260                 265                 270         


Trp Gly Ser Ser Ala Lys Asn Tyr Phe His Tyr Asn Gln Ser Tyr Pro 
        275                 280                 285             


Pro Thr Tyr Asn Val Lys Asp Met Leu Val Pro Thr Ala Val Trp Ser 
    290                 295                 300                 


Gly Gly His Asp Trp Leu Ala Asp Val Tyr Asp Val Asn Ile Leu Leu 
305                 310                 315                 320 


Thr Gln Ile Thr Asn Leu Val Phe His Glu Ser Ile Pro Glu Trp Glu 
                325                 330                 335     


His Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro Trp Arg Leu Tyr Asn 
            340                 345                 350         


Lys Ile Ile Asn Leu Met Arg Lys Tyr Gln 
        355                 360         


<210>  50
<211>  363
<212>  PRT
<213>  Homo sapiens

<400>  50

Val Ser Glu Ile Ile Ser Tyr Trp Gly Phe Pro Ser Glu Glu Tyr Leu 
1               5                   10                  15      


Val Glu Thr Glu Asp Gly Tyr Ile Leu Cys Leu Asn Arg Ile Pro His 
            20                  25                  30          


Gly Arg Lys Asn His Ser Asp Lys Gly Pro Lys Pro Val Val Phe Leu 
        35                  40                  45              


Gln His Gly Leu Leu Ala Asp Ser Ser Asn Trp Val Thr Asn Leu Ala 
    50                  55                  60                  


Asn Ser Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly Phe Asp Val Trp 
65                  70                  75                  80  


Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys His Lys Thr Leu 
                85                  90                  95      


Ser Val Ser Gln Asp Glu Phe Trp Ala Phe Ser Tyr Asp Glu Met Ala 
            100                 105                 110         


Lys Tyr Asp Leu Pro Ala Ser Ile Asn Phe Ile Leu Asn Lys Thr Gly 
        115                 120                 125             


Gln Glu Gln Val Tyr Tyr Val Gly His Ser Gln Gly Thr Thr Ile Gly 
    130                 135                 140                 


Phe Ile Ala Phe Ser Gln Ile Pro Glu Leu Ala Lys Arg Ile Lys Met 
145                 150                 155                 160 


Phe Phe Ala Leu Gly Pro Val Ala Ser Val Ala Phe Cys Thr Ser Pro 
                165                 170                 175     


Met Ala Lys Leu Gly Arg Leu Pro Asp His Leu Ile Lys Asp Leu Phe 
            180                 185                 190         


Gly Asp Lys Glu Phe Leu Pro Gln Ser Ala Phe Leu Lys Trp Leu Gly 
        195                 200                 205             


Thr His Val Cys Thr His Val Ile Leu Lys Glu Leu Cys Gly Asn Leu 
    210                 215                 220                 


Cys Phe Leu Leu Cys Gly Phe Asn Glu Arg Asn Leu Asn Met Ser Arg 
225                 230                 235                 240 


Val Asp Val Tyr Thr Thr His Ser Pro Ala Gly Thr Ser Val Gln Asn 
                245                 250                 255     


Met Leu His Trp Ser Gln Ala Val Lys Phe Gln Lys Phe Gln Ala Phe 
            260                 265                 270         


Asp Trp Gly Ser Ser Ala Lys Asn Tyr Phe His Tyr Asn Gln Ser Tyr 
        275                 280                 285             


Pro Pro Thr Tyr Asn Val Lys Asp Met Leu Val Pro Thr Ala Val Trp 
    290                 295                 300                 


Ser Gly Gly His Asp Trp Leu Ala Asp Val Tyr Asp Val Asn Ile Leu 
305                 310                 315                 320 


Leu Thr Gln Ile Thr Asn Leu Val Phe His Glu Ser Ile Pro Glu Trp 
                325                 330                 335     


Glu His Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro Trp Arg Leu Tyr 
            340                 345                 350         


Asn Lys Ile Ile Asn Leu Met Arg Lys Tyr Gln 
        355                 360             


<210>  51
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  51

Asn Val Ser Glu Ile Ile Ser Tyr Trp Gly Phe Pro Ser Glu Glu Tyr 
1               5                   10                  15      


Leu Val Glu Thr Glu Asp Gly Tyr Ile Leu Cys Leu Asn Arg Ile Pro 
            20                  25                  30          


His Gly Arg Lys Asn His Ser Asp Lys Gly Pro Lys Pro Val Val Phe 
        35                  40                  45              


Leu Gln His Gly Leu Leu Ala Asp Ser Ser Asn Trp Val Thr Asn Leu 
    50                  55                  60                  


Ala Asn Ser Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly Phe Asp Val 
65                  70                  75                  80  


Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys His Lys Thr 
                85                  90                  95      


Leu Ser Val Ser Gln Asp Glu Phe Trp Ala Phe Ser Tyr Asp Glu Met 
            100                 105                 110         


Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn Phe Ile Leu Asn Lys Thr 
        115                 120                 125             


Gly Gln Glu Gln Val Tyr Tyr Val Gly His Ser Gln Gly Thr Thr Ile 
    130                 135                 140                 


Gly Phe Ile Ala Phe Ser Gln Ile Pro Glu Leu Ala Lys Arg Ile Lys 
145                 150                 155                 160 


Met Phe Phe Ala Leu Gly Pro Val Ala Ser Val Ala Phe Cys Thr Ser 
                165                 170                 175     


Pro Met Ala Lys Leu Gly Arg Leu Pro Asp His Leu Ile Lys Asp Leu 
            180                 185                 190         


Phe Gly Asp Lys Glu Phe Leu Pro Gln Ser Ala Phe Leu Lys Trp Leu 
        195                 200                 205             


Gly Thr His Val Cys Thr His Val Ile Leu Lys Glu Leu Cys Gly Asn 
    210                 215                 220                 


Leu Cys Phe Leu Leu Cys Gly Phe Asn Glu Arg Asn Leu Asn Met Ser 
225                 230                 235                 240 


Arg Val Asp Val Tyr Thr Thr His Ser Pro Ala Gly Thr Ser Val Gln 
                245                 250                 255     


Asn Met Leu His Trp Ser Gln Ala Val Lys Phe Gln Lys Phe Gln Ala 
            260                 265                 270         


Phe Asp Trp Gly Ser Ser Ala Lys Asn Tyr Phe His Tyr Asn Gln Ser 
        275                 280                 285             


Tyr Pro Pro Thr Tyr Asn Val Lys Asp Met Leu Val Pro Thr Ala Val 
    290                 295                 300                 


Trp Ser Gly Gly His Asp Trp Leu Ala Asp Val Tyr Asp Val Asn Ile 
305                 310                 315                 320 


Leu Leu Thr Gln Ile Thr Asn Leu Val Phe His Glu Ser Ile Pro Glu 
                325                 330                 335     


Trp Glu His Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro Trp Arg Leu 
            340                 345                 350         


Tyr Asn Lys Ile Ile Asn Leu Met Arg Lys Tyr Gln 
        355                 360                 


<210>  52
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Asn Val Ser Glu Ile Ile Ser Tyr Trp Gly Phe Pro Ser Glu Glu 
1               5                   10                  15      


Tyr Leu Val Glu Thr Glu Asp Gly Tyr Ile Leu Cys Leu Asn Arg Ile 
            20                  25                  30          


Pro His Gly Arg Lys Asn His Ser Asp Lys Gly Pro Lys Pro Val Val 
        35                  40                  45              


Phe Leu Gln His Gly Leu Leu Ala Asp Ser Ser Asn Trp Val Thr Asn 
    50                  55                  60                  


Leu Ala Asn Ser Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly Phe Asp 
65                  70                  75                  80  


Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys His Lys 
                85                  90                  95      


Thr Leu Ser Val Ser Gln Asp Glu Phe Trp Ala Phe Ser Tyr Asp Glu 
            100                 105                 110         


Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn Phe Ile Leu Asn Lys 
        115                 120                 125             


Thr Gly Gln Glu Gln Val Tyr Tyr Val Gly His Ser Gln Gly Thr Thr 
    130                 135                 140                 


Ile Gly Phe Ile Ala Phe Ser Gln Ile Pro Glu Leu Ala Lys Arg Ile 
145                 150                 155                 160 


Lys Met Phe Phe Ala Leu Gly Pro Val Ala Ser Val Ala Phe Cys Thr 
                165                 170                 175     


Ser Pro Met Ala Lys Leu Gly Arg Leu Pro Asp His Leu Ile Lys Asp 
            180                 185                 190         


Leu Phe Gly Asp Lys Glu Phe Leu Pro Gln Ser Ala Phe Leu Lys Trp 
        195                 200                 205             


Leu Gly Thr His Val Cys Thr His Val Ile Leu Lys Glu Leu Cys Gly 
    210                 215                 220                 


Asn Leu Cys Phe Leu Leu Cys Gly Phe Asn Glu Arg Asn Leu Asn Met 
225                 230                 235                 240 


Ser Arg Val Asp Val Tyr Thr Thr His Ser Pro Ala Gly Thr Ser Val 
                245                 250                 255     


Gln Asn Met Leu His Trp Ser Gln Ala Val Lys Phe Gln Lys Phe Gln 
            260                 265                 270         


Ala Phe Asp Trp Gly Ser Ser Ala Lys Asn Tyr Phe His Tyr Asn Gln 
        275                 280                 285             


Ser Tyr Pro Pro Thr Tyr Asn Val Lys Asp Met Leu Val Pro Thr Ala 
    290                 295                 300                 


Val Trp Ser Gly Gly His Asp Trp Leu Ala Asp Val Tyr Asp Val Asn 
305                 310                 315                 320 


Ile Leu Leu Thr Gln Ile Thr Asn Leu Val Phe His Glu Ser Ile Pro 
                325                 330                 335     


Glu Trp Glu His Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro Trp Arg 
            340                 345                 350         


Leu Tyr Asn Lys Ile Ile Asn Leu Met Arg Lys Tyr Gln 
        355                 360                 365 


<210>  53
<211>  366
<212>  PRT
<213>  Homo sapiens

<400>  53

Asn Met Asn Val Ser Glu Ile Ile Ser Tyr Trp Gly Phe Pro Ser Glu 
1               5                   10                  15      


Glu Tyr Leu Val Glu Thr Glu Asp Gly Tyr Ile Leu Cys Leu Asn Arg 
            20                  25                  30          


Ile Pro His Gly Arg Lys Asn His Ser Asp Lys Gly Pro Lys Pro Val 
        35                  40                  45              


Val Phe Leu Gln His Gly Leu Leu Ala Asp Ser Ser Asn Trp Val Thr 
    50                  55                  60                  


Asn Leu Ala Asn Ser Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly Phe 
65                  70                  75                  80  


Asp Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys His 
                85                  90                  95      


Lys Thr Leu Ser Val Ser Gln Asp Glu Phe Trp Ala Phe Ser Tyr Asp 
            100                 105                 110         


Glu Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn Phe Ile Leu Asn 
        115                 120                 125             


Lys Thr Gly Gln Glu Gln Val Tyr Tyr Val Gly His Ser Gln Gly Thr 
    130                 135                 140                 


Thr Ile Gly Phe Ile Ala Phe Ser Gln Ile Pro Glu Leu Ala Lys Arg 
145                 150                 155                 160 


Ile Lys Met Phe Phe Ala Leu Gly Pro Val Ala Ser Val Ala Phe Cys 
                165                 170                 175     


Thr Ser Pro Met Ala Lys Leu Gly Arg Leu Pro Asp His Leu Ile Lys 
            180                 185                 190         


Asp Leu Phe Gly Asp Lys Glu Phe Leu Pro Gln Ser Ala Phe Leu Lys 
        195                 200                 205             


Trp Leu Gly Thr His Val Cys Thr His Val Ile Leu Lys Glu Leu Cys 
    210                 215                 220                 


Gly Asn Leu Cys Phe Leu Leu Cys Gly Phe Asn Glu Arg Asn Leu Asn 
225                 230                 235                 240 


Met Ser Arg Val Asp Val Tyr Thr Thr His Ser Pro Ala Gly Thr Ser 
                245                 250                 255     


Val Gln Asn Met Leu His Trp Ser Gln Ala Val Lys Phe Gln Lys Phe 
            260                 265                 270         


Gln Ala Phe Asp Trp Gly Ser Ser Ala Lys Asn Tyr Phe His Tyr Asn 
        275                 280                 285             


Gln Ser Tyr Pro Pro Thr Tyr Asn Val Lys Asp Met Leu Val Pro Thr 
    290                 295                 300                 


Ala Val Trp Ser Gly Gly His Asp Trp Leu Ala Asp Val Tyr Asp Val 
305                 310                 315                 320 


Asn Ile Leu Leu Thr Gln Ile Thr Asn Leu Val Phe His Glu Ser Ile 
                325                 330                 335     


Pro Glu Trp Glu His Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro Trp 
            340                 345                 350         


Arg Leu Tyr Asn Lys Ile Ile Asn Leu Met Arg Lys Tyr Gln 
        355                 360                 365     


<210>  54
<211>  367
<212>  PRT
<213>  Homo sapiens

<400>  54

Thr Asn Met Asn Val Ser Glu Ile Ile Ser Tyr Trp Gly Phe Pro Ser 
1               5                   10                  15      


Glu Glu Tyr Leu Val Glu Thr Glu Asp Gly Tyr Ile Leu Cys Leu Asn 
            20                  25                  30          


Arg Ile Pro His Gly Arg Lys Asn His Ser Asp Lys Gly Pro Lys Pro 
        35                  40                  45              


Val Val Phe Leu Gln His Gly Leu Leu Ala Asp Ser Ser Asn Trp Val 
    50                  55                  60                  


Thr Asn Leu Ala Asn Ser Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly 
65                  70                  75                  80  


Phe Asp Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys 
                85                  90                  95      


His Lys Thr Leu Ser Val Ser Gln Asp Glu Phe Trp Ala Phe Ser Tyr 
            100                 105                 110         


Asp Glu Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn Phe Ile Leu 
        115                 120                 125             


Asn Lys Thr Gly Gln Glu Gln Val Tyr Tyr Val Gly His Ser Gln Gly 
    130                 135                 140                 


Thr Thr Ile Gly Phe Ile Ala Phe Ser Gln Ile Pro Glu Leu Ala Lys 
145                 150                 155                 160 


Arg Ile Lys Met Phe Phe Ala Leu Gly Pro Val Ala Ser Val Ala Phe 
                165                 170                 175     


Cys Thr Ser Pro Met Ala Lys Leu Gly Arg Leu Pro Asp His Leu Ile 
            180                 185                 190         


Lys Asp Leu Phe Gly Asp Lys Glu Phe Leu Pro Gln Ser Ala Phe Leu 
        195                 200                 205             


Lys Trp Leu Gly Thr His Val Cys Thr His Val Ile Leu Lys Glu Leu 
    210                 215                 220                 


Cys Gly Asn Leu Cys Phe Leu Leu Cys Gly Phe Asn Glu Arg Asn Leu 
225                 230                 235                 240 


Asn Met Ser Arg Val Asp Val Tyr Thr Thr His Ser Pro Ala Gly Thr 
                245                 250                 255     


Ser Val Gln Asn Met Leu His Trp Ser Gln Ala Val Lys Phe Gln Lys 
            260                 265                 270         


Phe Gln Ala Phe Asp Trp Gly Ser Ser Ala Lys Asn Tyr Phe His Tyr 
        275                 280                 285             


Asn Gln Ser Tyr Pro Pro Thr Tyr Asn Val Lys Asp Met Leu Val Pro 
    290                 295                 300                 


Thr Ala Val Trp Ser Gly Gly His Asp Trp Leu Ala Asp Val Tyr Asp 
305                 310                 315                 320 


Val Asn Ile Leu Leu Thr Gln Ile Thr Asn Leu Val Phe His Glu Ser 
                325                 330                 335     


Ile Pro Glu Trp Glu His Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro 
            340                 345                 350         


Trp Arg Leu Tyr Asn Lys Ile Ile Asn Leu Met Arg Lys Tyr Gln 
        355                 360                 365         


<210>  55
<211>  368
<212>  PRT
<213>  Homo sapiens

<400>  55

Glu Thr Asn Met Asn Val Ser Glu Ile Ile Ser Tyr Trp Gly Phe Pro 
1               5                   10                  15      


Ser Glu Glu Tyr Leu Val Glu Thr Glu Asp Gly Tyr Ile Leu Cys Leu 
            20                  25                  30          


Asn Arg Ile Pro His Gly Arg Lys Asn His Ser Asp Lys Gly Pro Lys 
        35                  40                  45              


Pro Val Val Phe Leu Gln His Gly Leu Leu Ala Asp Ser Ser Asn Trp 
    50                  55                  60                  


Val Thr Asn Leu Ala Asn Ser Ser Leu Gly Phe Ile Leu Ala Asp Ala 
65                  70                  75                  80  


Gly Phe Asp Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg 
                85                  90                  95      


Lys His Lys Thr Leu Ser Val Ser Gln Asp Glu Phe Trp Ala Phe Ser 
            100                 105                 110         


Tyr Asp Glu Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn Phe Ile 
        115                 120                 125             


Leu Asn Lys Thr Gly Gln Glu Gln Val Tyr Tyr Val Gly His Ser Gln 
    130                 135                 140                 


Gly Thr Thr Ile Gly Phe Ile Ala Phe Ser Gln Ile Pro Glu Leu Ala 
145                 150                 155                 160 


Lys Arg Ile Lys Met Phe Phe Ala Leu Gly Pro Val Ala Ser Val Ala 
                165                 170                 175     


Phe Cys Thr Ser Pro Met Ala Lys Leu Gly Arg Leu Pro Asp His Leu 
            180                 185                 190         


Ile Lys Asp Leu Phe Gly Asp Lys Glu Phe Leu Pro Gln Ser Ala Phe 
        195                 200                 205             


Leu Lys Trp Leu Gly Thr His Val Cys Thr His Val Ile Leu Lys Glu 
    210                 215                 220                 


Leu Cys Gly Asn Leu Cys Phe Leu Leu Cys Gly Phe Asn Glu Arg Asn 
225                 230                 235                 240 


Leu Asn Met Ser Arg Val Asp Val Tyr Thr Thr His Ser Pro Ala Gly 
                245                 250                 255     


Thr Ser Val Gln Asn Met Leu His Trp Ser Gln Ala Val Lys Phe Gln 
            260                 265                 270         


Lys Phe Gln Ala Phe Asp Trp Gly Ser Ser Ala Lys Asn Tyr Phe His 
        275                 280                 285             


Tyr Asn Gln Ser Tyr Pro Pro Thr Tyr Asn Val Lys Asp Met Leu Val 
    290                 295                 300                 


Pro Thr Ala Val Trp Ser Gly Gly His Asp Trp Leu Ala Asp Val Tyr 
305                 310                 315                 320 


Asp Val Asn Ile Leu Leu Thr Gln Ile Thr Asn Leu Val Phe His Glu 
                325                 330                 335     


Ser Ile Pro Glu Trp Glu His Leu Asp Phe Ile Trp Gly Leu Asp Ala 
            340                 345                 350         


Pro Trp Arg Leu Tyr Asn Lys Ile Ile Asn Leu Met Arg Lys Tyr Gln 
        355                 360                 365             


<210>  56
<211>  369
<212>  PRT
<213>  Homo sapiens

<400>  56

Pro Glu Thr Asn Met Asn Val Ser Glu Ile Ile Ser Tyr Trp Gly Phe 
1               5                   10                  15      


Pro Ser Glu Glu Tyr Leu Val Glu Thr Glu Asp Gly Tyr Ile Leu Cys 
            20                  25                  30          


Leu Asn Arg Ile Pro His Gly Arg Lys Asn His Ser Asp Lys Gly Pro 
        35                  40                  45              


Lys Pro Val Val Phe Leu Gln His Gly Leu Leu Ala Asp Ser Ser Asn 
    50                  55                  60                  


Trp Val Thr Asn Leu Ala Asn Ser Ser Leu Gly Phe Ile Leu Ala Asp 
65                  70                  75                  80  


Ala Gly Phe Asp Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser 
                85                  90                  95      


Arg Lys His Lys Thr Leu Ser Val Ser Gln Asp Glu Phe Trp Ala Phe 
            100                 105                 110         


Ser Tyr Asp Glu Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn Phe 
        115                 120                 125             


Ile Leu Asn Lys Thr Gly Gln Glu Gln Val Tyr Tyr Val Gly His Ser 
    130                 135                 140                 


Gln Gly Thr Thr Ile Gly Phe Ile Ala Phe Ser Gln Ile Pro Glu Leu 
145                 150                 155                 160 


Ala Lys Arg Ile Lys Met Phe Phe Ala Leu Gly Pro Val Ala Ser Val 
                165                 170                 175     


Ala Phe Cys Thr Ser Pro Met Ala Lys Leu Gly Arg Leu Pro Asp His 
            180                 185                 190         


Leu Ile Lys Asp Leu Phe Gly Asp Lys Glu Phe Leu Pro Gln Ser Ala 
        195                 200                 205             


Phe Leu Lys Trp Leu Gly Thr His Val Cys Thr His Val Ile Leu Lys 
    210                 215                 220                 


Glu Leu Cys Gly Asn Leu Cys Phe Leu Leu Cys Gly Phe Asn Glu Arg 
225                 230                 235                 240 


Asn Leu Asn Met Ser Arg Val Asp Val Tyr Thr Thr His Ser Pro Ala 
                245                 250                 255     


Gly Thr Ser Val Gln Asn Met Leu His Trp Ser Gln Ala Val Lys Phe 
            260                 265                 270         


Gln Lys Phe Gln Ala Phe Asp Trp Gly Ser Ser Ala Lys Asn Tyr Phe 
        275                 280                 285             


His Tyr Asn Gln Ser Tyr Pro Pro Thr Tyr Asn Val Lys Asp Met Leu 
    290                 295                 300                 


Val Pro Thr Ala Val Trp Ser Gly Gly His Asp Trp Leu Ala Asp Val 
305                 310                 315                 320 


Tyr Asp Val Asn Ile Leu Leu Thr Gln Ile Thr Asn Leu Val Phe His 
                325                 330                 335     


Glu Ser Ile Pro Glu Trp Glu His Leu Asp Phe Ile Trp Gly Leu Asp 
            340                 345                 350         


Ala Pro Trp Arg Leu Tyr Asn Lys Ile Ile Asn Leu Met Arg Lys Tyr 
        355                 360                 365             


Gln 
    


<210>  57
<211>  370
<212>  PRT
<213>  Homo sapiens

<400>  57

Asp Pro Glu Thr Asn Met Asn Val Ser Glu Ile Ile Ser Tyr Trp Gly 
1               5                   10                  15      


Phe Pro Ser Glu Glu Tyr Leu Val Glu Thr Glu Asp Gly Tyr Ile Leu 
            20                  25                  30          


Cys Leu Asn Arg Ile Pro His Gly Arg Lys Asn His Ser Asp Lys Gly 
        35                  40                  45              


Pro Lys Pro Val Val Phe Leu Gln His Gly Leu Leu Ala Asp Ser Ser 
    50                  55                  60                  


Asn Trp Val Thr Asn Leu Ala Asn Ser Ser Leu Gly Phe Ile Leu Ala 
65                  70                  75                  80  


Asp Ala Gly Phe Asp Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp 
                85                  90                  95      


Ser Arg Lys His Lys Thr Leu Ser Val Ser Gln Asp Glu Phe Trp Ala 
            100                 105                 110         


Phe Ser Tyr Asp Glu Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn 
        115                 120                 125             


Phe Ile Leu Asn Lys Thr Gly Gln Glu Gln Val Tyr Tyr Val Gly His 
    130                 135                 140                 


Ser Gln Gly Thr Thr Ile Gly Phe Ile Ala Phe Ser Gln Ile Pro Glu 
145                 150                 155                 160 


Leu Ala Lys Arg Ile Lys Met Phe Phe Ala Leu Gly Pro Val Ala Ser 
                165                 170                 175     


Val Ala Phe Cys Thr Ser Pro Met Ala Lys Leu Gly Arg Leu Pro Asp 
            180                 185                 190         


His Leu Ile Lys Asp Leu Phe Gly Asp Lys Glu Phe Leu Pro Gln Ser 
        195                 200                 205             


Ala Phe Leu Lys Trp Leu Gly Thr His Val Cys Thr His Val Ile Leu 
    210                 215                 220                 


Lys Glu Leu Cys Gly Asn Leu Cys Phe Leu Leu Cys Gly Phe Asn Glu 
225                 230                 235                 240 


Arg Asn Leu Asn Met Ser Arg Val Asp Val Tyr Thr Thr His Ser Pro 
                245                 250                 255     


Ala Gly Thr Ser Val Gln Asn Met Leu His Trp Ser Gln Ala Val Lys 
            260                 265                 270         


Phe Gln Lys Phe Gln Ala Phe Asp Trp Gly Ser Ser Ala Lys Asn Tyr 
        275                 280                 285             


Phe His Tyr Asn Gln Ser Tyr Pro Pro Thr Tyr Asn Val Lys Asp Met 
    290                 295                 300                 


Leu Val Pro Thr Ala Val Trp Ser Gly Gly His Asp Trp Leu Ala Asp 
305                 310                 315                 320 


Val Tyr Asp Val Asn Ile Leu Leu Thr Gln Ile Thr Asn Leu Val Phe 
                325                 330                 335     


His Glu Ser Ile Pro Glu Trp Glu His Leu Asp Phe Ile Trp Gly Leu 
            340                 345                 350         


Asp Ala Pro Trp Arg Leu Tyr Asn Lys Ile Ile Asn Leu Met Arg Lys 
        355                 360                 365             


Tyr Gln 
    370 


<210>  58
<211>  371
<212>  PRT
<213>  Homo sapiens

<400>  58

Val Asp Pro Glu Thr Asn Met Asn Val Ser Glu Ile Ile Ser Tyr Trp 
1               5                   10                  15      


Gly Phe Pro Ser Glu Glu Tyr Leu Val Glu Thr Glu Asp Gly Tyr Ile 
            20                  25                  30          


Leu Cys Leu Asn Arg Ile Pro His Gly Arg Lys Asn His Ser Asp Lys 
        35                  40                  45              


Gly Pro Lys Pro Val Val Phe Leu Gln His Gly Leu Leu Ala Asp Ser 
    50                  55                  60                  


Ser Asn Trp Val Thr Asn Leu Ala Asn Ser Ser Leu Gly Phe Ile Leu 
65                  70                  75                  80  


Ala Asp Ala Gly Phe Asp Val Trp Met Gly Asn Ser Arg Gly Asn Thr 
                85                  90                  95      


Trp Ser Arg Lys His Lys Thr Leu Ser Val Ser Gln Asp Glu Phe Trp 
            100                 105                 110         


Ala Phe Ser Tyr Asp Glu Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile 
        115                 120                 125             


Asn Phe Ile Leu Asn Lys Thr Gly Gln Glu Gln Val Tyr Tyr Val Gly 
    130                 135                 140                 


His Ser Gln Gly Thr Thr Ile Gly Phe Ile Ala Phe Ser Gln Ile Pro 
145                 150                 155                 160 


Glu Leu Ala Lys Arg Ile Lys Met Phe Phe Ala Leu Gly Pro Val Ala 
                165                 170                 175     


Ser Val Ala Phe Cys Thr Ser Pro Met Ala Lys Leu Gly Arg Leu Pro 
            180                 185                 190         


Asp His Leu Ile Lys Asp Leu Phe Gly Asp Lys Glu Phe Leu Pro Gln 
        195                 200                 205             


Ser Ala Phe Leu Lys Trp Leu Gly Thr His Val Cys Thr His Val Ile 
    210                 215                 220                 


Leu Lys Glu Leu Cys Gly Asn Leu Cys Phe Leu Leu Cys Gly Phe Asn 
225                 230                 235                 240 


Glu Arg Asn Leu Asn Met Ser Arg Val Asp Val Tyr Thr Thr His Ser 
                245                 250                 255     


Pro Ala Gly Thr Ser Val Gln Asn Met Leu His Trp Ser Gln Ala Val 
            260                 265                 270         


Lys Phe Gln Lys Phe Gln Ala Phe Asp Trp Gly Ser Ser Ala Lys Asn 
        275                 280                 285             


Tyr Phe His Tyr Asn Gln Ser Tyr Pro Pro Thr Tyr Asn Val Lys Asp 
    290                 295                 300                 


Met Leu Val Pro Thr Ala Val Trp Ser Gly Gly His Asp Trp Leu Ala 
305                 310                 315                 320 


Asp Val Tyr Asp Val Asn Ile Leu Leu Thr Gln Ile Thr Asn Leu Val 
                325                 330                 335     


Phe His Glu Ser Ile Pro Glu Trp Glu His Leu Asp Phe Ile Trp Gly 
            340                 345                 350         


Leu Asp Ala Pro Trp Arg Leu Tyr Asn Lys Ile Ile Asn Leu Met Arg 
        355                 360                 365             


Lys Tyr Gln 
    370     


<210>  59
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  59
gactacaagg atgacgatga caaa                                              24


<210>  60
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  60

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  61
<211>  405
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Lys Met Arg Phe Leu Gly Leu Val Val Cys Leu Val Leu Trp Thr 
1               5                   10                  15      


Leu His Ser Glu Gly Ser Gly Gly Lys Leu Thr Ala Val Asp Pro Glu 
            20                  25                  30          


Thr Asn Met Asn Val Ser Glu Ile Ile Ser Tyr Trp Gly Phe Pro Ser 
        35                  40                  45              


Glu Glu Tyr Leu Val Glu Thr Glu Asp Gly Tyr Ile Leu Cys Leu Asn 
    50                  55                  60                  


Arg Ile Pro His Gly Arg Lys Asn His Ser Asp Tyr Lys Asp Asp Asp 
65                  70                  75                  80  


Asp Lys Gly Pro Lys Pro Val Val Phe Leu Gln His Gly Leu Leu Ala 
                85                  90                  95      


Asp Ser Ser Asn Trp Val Thr Asn Leu Ala Asn Ser Ser Leu Gly Phe 
            100                 105                 110         


Ile Leu Ala Asp Ala Gly Phe Asp Val Trp Met Gly Asn Ser Arg Gly 
        115                 120                 125             


Asn Thr Trp Ser Arg Lys His Lys Thr Leu Ser Val Ser Gln Asp Glu 
    130                 135                 140                 


Phe Trp Ala Phe Ser Tyr Asp Glu Met Ala Lys Tyr Asp Leu Pro Ala 
145                 150                 155                 160 


Ser Ile Asn Phe Ile Leu Asn Lys Thr Gly Gln Glu Gln Val Tyr Tyr 
                165                 170                 175     


Val Gly His Ser Gln Gly Thr Thr Ile Gly Phe Ile Ala Phe Ser Gln 
            180                 185                 190         


Ile Pro Glu Leu Ala Lys Arg Ile Lys Met Phe Phe Ala Leu Gly Pro 
        195                 200                 205             


Val Ala Ser Val Ala Phe Cys Thr Ser Pro Met Ala Lys Leu Gly Arg 
    210                 215                 220                 


Leu Pro Asp His Leu Ile Lys Asp Leu Phe Gly Asp Lys Glu Phe Leu 
225                 230                 235                 240 


Pro Gln Ser Ala Phe Leu Lys Trp Leu Gly Thr His Val Cys Thr His 
                245                 250                 255     


Val Ile Leu Lys Glu Leu Cys Gly Asn Leu Cys Phe Leu Leu Cys Gly 
            260                 265                 270         


Phe Asn Glu Arg Asn Leu Asn Met Ser Arg Val Asp Val Tyr Thr Thr 
        275                 280                 285             


His Ser Pro Ala Gly Thr Ser Val Gln Asn Met Leu His Trp Ser Gln 
    290                 295                 300                 


Ala Val Lys Phe Gln Lys Phe Gln Ala Phe Asp Trp Gly Ser Ser Ala 
305                 310                 315                 320 


Lys Asn Tyr Phe His Tyr Asn Gln Ser Tyr Pro Pro Thr Tyr Asn Val 
                325                 330                 335     


Lys Asp Met Leu Val Pro Thr Ala Val Trp Ser Gly Gly His Asp Trp 
            340                 345                 350         


Leu Ala Asp Val Tyr Asp Val Asn Ile Leu Leu Thr Gln Ile Thr Asn 
        355                 360                 365             


Leu Val Phe His Glu Ser Ile Pro Glu Trp Glu His Leu Asp Phe Ile 
    370                 375                 380                 


Trp Gly Leu Asp Ala Pro Trp Arg Leu Tyr Asn Lys Ile Ile Asn Leu 
385                 390                 395                 400 


Met Arg Lys Tyr Gln 
                405 


<210>  62
<211>  48
<212>  DNA
<213>  Homo sapiens

<400>  62
aagaaccatt ctgactacaa ggatgacgat gacaaaggtc ccaaacca                    48


<210>  63
<211>  48
<212>  DNA
<213>  Homo sapiens

<400>  63
tggtttggga cctttgtcat cgtcatcctt gtagtcagaa tggttctt                    48


<210>  64
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  None

<400>  64

Asp Asp Asp Asp Lys 
1               5   


<210>  65
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  None


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be Glu or Asp

<400>  65

Ile Xaa Gly Arg 
1               


<210>  66
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  None


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  66

Arg Xaa Xaa Arg 
1               


<210>  67
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  None

<400>  67

Pro Gly Ala Ala His Tyr 
1               5       


<210>  68
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Lys Met Arg Phe Leu Gly Leu Val Val Cys Leu Val Leu Trp Thr 
1               5                   10                  15      


Leu His Ser Glu Gly Ser Gly Gly Lys Leu Thr Ala Val Asp Pro Glu 
            20                  25                  30          


Thr Asn Met Asn Val Ser Glu Ile Ile Ser Tyr Trp Gly Phe Pro Ser 
        35                  40                  45              


Glu Glu Tyr Leu Val Glu Thr Glu Asp Gly Tyr Ile Leu Cys Leu Asn 
    50                  55                  60                  


Arg Ile Pro His Gly Arg Lys Asn His Ser Asp Tyr Lys Asp Asp Asp 
65                  70                  75                  80  


Asp Lys Lys Gly Pro Lys Pro Val Val Phe Leu Gln His Gly Leu Leu 
                85                  90                  95      


Ala Asp Ser Ser Asn Trp Val Thr Asn Leu Ala Asn Ser Ser Leu Gly 
            100                 105                 110         


Phe Ile Leu Ala Asp Ala Gly Phe Asp Val Trp Met Gly Asn Ser Arg 
        115                 120                 125             


Gly Asn Thr Trp Ser Arg Lys His Lys Thr Leu Ser Val Ser Gln Asp 
    130                 135                 140                 


Glu Phe Trp Ala Phe Ser Tyr Asp Glu Met Ala Lys Tyr Asp Leu Pro 
145                 150                 155                 160 


Ala Ser Ile Asn Phe Ile Leu Asn Lys Thr Gly Gln Glu Gln Val Tyr 
                165                 170                 175     


Tyr Val Gly His Ser Gln Gly Thr Thr Ile Gly Phe Ile Ala Phe Ser 
            180                 185                 190         


Gln Ile Pro Glu Leu Ala Lys Arg Ile Lys Met Phe Phe Ala Leu Gly 
        195                 200                 205             


Pro Val Ala Ser Val Ala Phe Cys Thr Ser Pro Met Ala Lys Leu Gly 
    210                 215                 220                 


Arg Leu Pro Asp His Leu Ile Lys Asp Leu Phe Gly Asp Lys Glu Phe 
225                 230                 235                 240 


Leu Pro Gln Ser Ala Phe Leu Lys Trp Leu Gly Thr His Val Cys Thr 
                245                 250                 255     


His Val Ile Leu Lys Glu Leu Cys Gly Asn Leu Cys Phe Leu Leu Cys 
            260                 265                 270         


Gly Phe Asn Glu Arg Asn Leu Asn Met Ser Arg Val Asp Val Tyr Thr 
        275                 280                 285             


Thr His Ser Pro Ala Gly Thr Ser Val Gln Asn Met Leu His Trp Ser 
    290                 295                 300                 


Gln Ala Val Lys Phe Gln Lys Phe Gln Ala Phe Asp Trp Gly Ser Ser 
305                 310                 315                 320 


Ala Lys Asn Tyr Phe His Tyr Asn Gln Ser Tyr Pro Pro Thr Tyr Asn 
                325                 330                 335     


Val Lys Asp Met Leu Val Pro Thr Ala Val Trp Ser Gly Gly His Asp 
            340                 345                 350         


Trp Leu Ala Asp Val Tyr Asp Val Asn Ile Leu Leu Thr Gln Ile Thr 
        355                 360                 365             


Asn Leu Val Phe His Glu Ser Ile Pro Glu Trp Glu His Leu Asp Phe 
    370                 375                 380                 


Ile Trp Gly Leu Asp Ala Pro Trp Arg Leu Tyr Asn Lys Ile Ile Asn 
385                 390                 395                 400 


Leu Met Arg Lys Tyr Gln 
                405     


