                               SEQUENCE LISTING

<110> D.E. SHAW RESEARCH, LLC
 
<120> METHODS FOR SCREENING VOLTAGE GATED PROTEINS

<130> 2206689.121WO1

<140> PCT/US2013/028324
<141> 2013-02-28

<150> 61/604,897
<151> 2012-02-29

<160> 203   

<170> PatentIn version 3.5

<210> 1
<211> 656
<212> PRT
<213> Drosophila melanogaster

<400> 1
Met Ala Ala Val Ala Gly Leu Tyr Gly Leu Gly Glu Asp Arg Gln His 
1               5                   10                  15      


Arg Lys Lys Gln Gln Gln Gln Gln Gln His Gln Lys Glu Gln Leu Glu 
            20                  25                  30          


Gln Lys Glu Glu Gln Lys Lys Ile Ala Glu Arg Lys Leu Gln Leu Arg 
        35                  40                  45              


Glu Gln Gln Leu Gln Arg Asn Ser Leu Asp Gly Tyr Gly Ser Leu Pro 
    50                  55                  60                  


Lys Leu Ser Ser Gln Asp Glu Glu Gly Gly Ala Gly His Gly Phe Gly 
65                  70                  75                  80  


Gly Gly Pro Gln His Phe Glu Pro Ile Pro His Asp His Asp Phe Cys 
                85                  90                  95      


Glu Arg Val Val Ile Asn Val Ser Gly Leu Arg Phe Glu Thr Gln Leu 
            100                 105                 110         


Arg Thr Leu Asn Gln Phe Pro Asp Thr Leu Leu Gly Asp Pro Ala Arg 
        115                 120                 125             


Arg Leu Arg Tyr Phe Asp Pro Leu Arg Asn Glu Tyr Phe Phe Asp Arg 
    130                 135                 140                 


Ser Arg Pro Ser Phe Asp Ala Ile Leu Tyr Tyr Tyr Gln Ser Gly Gly 
145                 150                 155                 160 


Arg Leu Arg Arg Pro Val Asn Val Pro Leu Asp Val Phe Ser Glu Glu 
                165                 170                 175     


Ile Lys Phe Tyr Glu Leu Gly Asp Gln Ala Ile Asn Lys Phe Arg Glu 
            180                 185                 190         


Asp Glu Gly Phe Ile Lys Glu Glu Glu Arg Pro Leu Pro Asp Asn Glu 
        195                 200                 205             


Lys Gln Arg Lys Val Trp Leu Leu Phe Glu Tyr Pro Glu Ser Ser Gln 
    210                 215                 220                 


Ala Ala Arg Val Val Ala Ile Ile Ser Val Phe Val Ile Leu Leu Ser 
225                 230                 235                 240 


Ile Val Ile Phe Cys Leu Glu Thr Leu Pro Glu Phe Lys His Tyr Lys 
                245                 250                 255     


Val Phe Asn Thr Thr Thr Asn Gly Thr Lys Ile Glu Glu Asp Glu Val 
            260                 265                 270         


Pro Asp Ile Thr Asp Pro Phe Phe Leu Ile Glu Thr Leu Cys Ile Ile 
        275                 280                 285             


Trp Phe Thr Phe Glu Leu Thr Val Arg Phe Leu Ala Cys Pro Asn Lys 
    290                 295                 300                 


Leu Asn Phe Cys Arg Asp Val Met Asn Val Ile Asp Ile Ile Ala Ile 
305                 310                 315                 320 


Ile Pro Tyr Phe Ile Thr Leu Ala Thr Val Val Ala Glu Glu Glu Asp 
                325                 330                 335     


Thr Leu Asn Leu Pro Lys Ala Pro Val Ser Pro Gln Asp Lys Ser Ser 
            340                 345                 350         


Asn Gln Ala Met Ser Leu Ala Ile Leu Arg Val Ile Arg Leu Val Arg 
        355                 360                 365             


Val Phe Arg Ile Phe Lys Leu Ser Arg His Ser Lys Gly Leu Gln Ile 
    370                 375                 380                 


Leu Gly Arg Thr Leu Lys Ala Ser Met Arg Glu Leu Gly Leu Leu Ile 
385                 390                 395                 400 


Phe Phe Leu Phe Ile Gly Val Val Leu Phe Ser Ser Ala Val Tyr Phe 
                405                 410                 415     


Ala Glu Ala Gly Ser Glu Asn Ser Phe Phe Lys Ser Ile Pro Asp Ala 
            420                 425                 430         


Phe Trp Trp Ala Val Val Thr Met Thr Thr Val Gly Tyr Gly Asp Met 
        435                 440                 445             


Thr Pro Val Gly Val Trp Gly Lys Ile Val Gly Ser Leu Cys Ala Ile 
    450                 455                 460                 


Ala Gly Val Leu Thr Ile Ala Leu Pro Val Pro Val Ile Val Ser Asn 
465                 470                 475                 480 


Phe Asn Tyr Phe Tyr His Arg Glu Thr Asp Gln Glu Glu Met Gln Ser 
                485                 490                 495     


Gln Asn Phe Asn His Val Thr Ser Cys Pro Tyr Leu Pro Gly Thr Leu 
            500                 505                 510         


Gly Gln His Met Lys Lys Ser Ser Leu Ser Glu Ser Ser Ser Asp Met 
        515                 520                 525             


Met Asp Leu Asp Asp Gly Val Glu Ser Thr Pro Gly Leu Thr Glu Thr 
    530                 535                 540                 


His Pro Gly Arg Ser Ala Val Ala Pro Phe Leu Gly Ala Gln Gln Gln 
545                 550                 555                 560 


Gln Gln Gln Gln Pro Val Ala Ser Ser Leu Ser Met Ser Ile Asp Lys 
                565                 570                 575     


Gln Leu Gln His Pro Leu Gln His Val Thr Gln Thr Gln Leu Tyr Gln 
            580                 585                 590         


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Asn Gly Phe Lys Gln Gln 
        595                 600                 605             


Gln Gln Gln Thr Gln Gln Gln Leu Gln Gln Gln Gln Ser His Thr Ile 
    610                 615                 620                 


Asn Ala Ser Ala Ala Ala Ala Thr Ser Gly Ser Gly Ser Ser Gly Leu 
625                 630                 635                 640 


Thr Met Arg His Asn Asn Ala Leu Ala Val Ser Ile Glu Thr Asp Val 
                645                 650                 655     


<210> 2
<211> 2009
<212> PRT
<213> Homo sapiens

<400> 2
Met Glu Gln Thr Val Leu Val Pro Pro Gly Pro Asp Ser Phe Asn Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Arg Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Asn Pro Lys Pro Asp Lys Lys Asp Asp Asp Glu Asn Gly 
        35                  40                  45              


Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
    50                  55                  60                  


Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
65                  70                  75                  80  


Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys Gly 
                85                  90                  95      


Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
            100                 105                 110         


Pro Phe Asn Pro Leu Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
        115                 120                 125             


Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
    130                 135                 140                 


Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Ile Ala Arg 
                165                 170                 175     


Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
            180                 185                 190         


Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val Asp 
        195                 200                 205             


Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
    210                 215                 220                 


Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
225                 230                 235                 240 


Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                245                 250                 255     


Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
            260                 265                 270         


Leu Arg Asn Lys Cys Ile Gln Trp Pro Pro Thr Asn Ala Ser Leu Glu 
        275                 280                 285             


Glu His Ser Ile Glu Lys Asn Ile Thr Val Asn Tyr Asn Gly Thr Leu 
    290                 295                 300                 


Ile Asn Glu Thr Val Phe Glu Phe Asp Trp Lys Ser Tyr Ile Gln Asp 
305                 310                 315                 320 


Ser Arg Tyr His Tyr Phe Leu Glu Gly Phe Leu Asp Ala Leu Leu Cys 
                325                 330                 335     


Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Met Cys Val 
            340                 345                 350         


Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr Phe 
        355                 360                 365             


Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Phe Trp 
    370                 375                 380                 


Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met 
385                 390                 395                 400 


Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn 
                405                 410                 415     


Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala 
            420                 425                 430         


Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met Ile 
        435                 440                 445             


Glu Gln Leu Lys Lys Gln Gln Glu Ala Ala Gln Gln Ala Ala Thr Ala 
    450                 455                 460                 


Thr Ala Ser Glu His Ser Arg Glu Pro Ser Ala Ala Gly Arg Leu Ser 
465                 470                 475                 480 


Asp Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu 
                485                 490                 495     


Arg Arg Asn Arg Arg Lys Lys Arg Lys Gln Lys Glu Gln Ser Gly Gly 
            500                 505                 510         


Glu Glu Lys Asp Glu Asp Glu Phe Gln Lys Ser Glu Ser Glu Asp Ser 
        515                 520                 525             


Ile Arg Arg Lys Gly Phe Arg Phe Ser Ile Glu Gly Asn Arg Leu Thr 
    530                 535                 540                 


Tyr Glu Lys Arg Tyr Ser Ser Pro His Gln Ser Leu Leu Ser Ile Arg 
545                 550                 555                 560 


Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Thr Ser Leu Phe Ser 
                565                 570                 575     


Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp Phe Ala Asp 
            580                 585                 590         


Asp Glu His Ser Thr Phe Glu Asp Asn Glu Ser Arg Arg Asp Ser Leu 
        595                 600                 605             


Phe Val Pro Arg Arg His Gly Glu Arg Arg Asn Ser Asn Leu Ser Gln 
    610                 615                 620                 


Thr Ser Arg Ser Ser Arg Met Leu Ala Val Phe Pro Ala Asn Gly Lys 
625                 630                 635                 640 


Met His Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Val Gly Gly 
                645                 650                 655     


Pro Ser Val Pro Thr Ser Pro Val Gly Gln Leu Leu Pro Glu Val Ile 
            660                 665                 670         


Ile Asp Lys Pro Ala Thr Asp Asp Asn Gly Thr Thr Thr Glu Thr Glu 
        675                 680                 685             


Met Arg Lys Arg Arg Ser Ser Ser Phe His Val Ser Met Asp Phe Leu 
    690                 695                 700                 


Glu Asp Pro Ser Gln Arg Gln Arg Ala Met Ser Ile Ala Ser Ile Leu 
705                 710                 715                 720 


Thr Asn Thr Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro 
                725                 730                 735     


Cys Trp Tyr Lys Phe Ser Asn Ile Phe Leu Ile Trp Asp Cys Ser Pro 
            740                 745                 750         


Tyr Trp Leu Lys Val Lys His Val Val Asn Leu Val Val Met Asp Pro 
        755                 760                 765             


Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe 
    770                 775                 780                 


Met Ala Met Glu His Tyr Pro Met Thr Asp His Phe Asn Asn Val Leu 
785                 790                 795                 800 


Thr Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Phe 
                805                 810                 815     


Leu Lys Ile Ile Ala Met Asp Pro Tyr Tyr Tyr Phe Gln Glu Gly Trp 
            820                 825                 830         


Asn Ile Phe Asp Gly Phe Ile Val Thr Leu Ser Leu Val Glu Leu Gly 
        835                 840                 845             


Leu Ala Asn Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu 
    850                 855                 860                 


Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile 
865                 870                 875                 880 


Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val 
                885                 890                 895     


Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe 
            900                 905                 910         


Gly Lys Ser Tyr Lys Asp Cys Val Cys Lys Ile Ala Ser Asp Cys Gln 
        915                 920                 925             


Leu Pro Arg Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val 
    930                 935                 940                 


Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met 
945                 950                 955                 960 


Glu Val Ala Gly Gln Ala Met Cys Leu Thr Val Phe Met Met Val Met 
                965                 970                 975     


Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu 
            980                 985                 990         


Ser Ser Phe Ser Ala Asp Asn Leu  Ala Ala Thr Asp Asp  Asp Asn Glu 
        995                 1000                 1005             


Met Asn  Asn Leu Gln Ile Ala  Val Asp Arg Met His  Lys Gly Val 
    1010                 1015                 1020             


Ala Tyr  Val Lys Arg Lys Ile  Tyr Glu Phe Ile Gln  Gln Ser Phe 
    1025                 1030                 1035             


Ile Arg  Lys Gln Lys Ile Leu  Asp Glu Ile Lys Pro  Leu Asp Asp 
    1040                 1045                 1050             


Leu Asn  Asn Lys Lys Asp Ser  Cys Met Ser Asn His  Thr Ala Glu 
    1055                 1060                 1065             


Ile Gly  Lys Asp Leu Asp Tyr  Leu Lys Asp Val Asn  Gly Thr Thr 
    1070                 1075                 1080             


Ser Gly  Ile Gly Thr Gly Ser  Ser Val Glu Lys Tyr  Ile Ile Asp 
    1085                 1090                 1095             


Glu Ser  Asp Tyr Met Ser Phe  Ile Asn Asn Pro Ser  Leu Thr Val 
    1100                 1105                 1110             


Thr Val  Pro Ile Ala Val Gly  Glu Ser Asp Phe Glu  Asn Leu Asn 
    1115                 1120                 1125             


Thr Glu  Asp Phe Ser Ser Glu  Ser Asp Leu Glu Glu  Ser Lys Glu 
    1130                 1135                 1140             


Lys Leu  Asn Glu Ser Ser Ser  Ser Ser Glu Gly Ser  Thr Val Asp 
    1145                 1150                 1155             


Ile Gly  Ala Pro Val Glu Glu  Gln Pro Val Val Glu  Pro Glu Glu 
    1160                 1165                 1170             


Thr Leu  Glu Pro Glu Ala Cys  Phe Thr Glu Gly Cys  Val Gln Arg 
    1175                 1180                 1185             


Phe Lys  Cys Cys Gln Ile Asn  Val Glu Glu Gly Arg  Gly Lys Gln 
    1190                 1195                 1200             


Trp Trp  Asn Leu Arg Arg Thr  Cys Phe Arg Ile Val  Glu His Asn 
    1205                 1210                 1215             


Trp Phe  Glu Thr Phe Ile Val  Phe Met Ile Leu Leu  Ser Ser Gly 
    1220                 1225                 1230             


Ala Leu  Ala Phe Glu Asp Ile  Tyr Ile Asp Gln Arg  Lys Thr Ile 
    1235                 1240                 1245             


Lys Thr  Met Leu Glu Tyr Ala  Asp Lys Val Phe Thr  Tyr Ile Phe 
    1250                 1255                 1260             


Ile Leu  Glu Met Leu Leu Lys  Trp Val Ala Tyr Gly  Tyr Gln Thr 
    1265                 1270                 1275             


Tyr Phe  Thr Asn Ala Trp Cys  Trp Leu Asp Phe Leu  Ile Val Asp 
    1280                 1285                 1290             


Val Ser  Leu Val Ser Leu Thr  Ala Asn Ala Leu Gly  Tyr Ser Glu 
    1295                 1300                 1305             


Leu Gly  Ala Ile Lys Ser Leu  Arg Thr Leu Arg Ala  Leu Arg Pro 
    1310                 1315                 1320             


Leu Arg  Ala Leu Ser Arg Phe  Glu Gly Met Arg Val  Val Val Asn 
    1325                 1330                 1335             


Ala Leu  Leu Gly Ala Ile Pro  Ser Ile Met Asn Val  Leu Leu Val 
    1340                 1345                 1350             


Cys Leu  Ile Phe Trp Leu Ile  Phe Ser Ile Met Gly  Val Asn Leu 
    1355                 1360                 1365             


Phe Ala  Gly Lys Phe Tyr His  Cys Ile Asn Thr Thr  Thr Gly Asp 
    1370                 1375                 1380             


Arg Phe  Asp Ile Glu Asp Val  Asn Asn His Thr Asp  Cys Leu Lys 
    1385                 1390                 1395             


Leu Ile  Glu Arg Asn Glu Thr  Ala Arg Trp Lys Asn  Val Lys Val 
    1400                 1405                 1410             


Asn Phe  Asp Asn Val Gly Phe  Gly Tyr Leu Ser Leu  Leu Gln Val 
    1415                 1420                 1425             


Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met Tyr Ala  Ala Val Asp 
    1430                 1435                 1440             


Ser Arg  Asn Val Glu Leu Gln  Pro Lys Tyr Glu Glu  Ser Leu Tyr 
    1445                 1450                 1455             


Met Tyr  Leu Tyr Phe Val Ile  Phe Ile Ile Phe Gly  Ser Phe Phe 
    1460                 1465                 1470             


Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile Asp Asn  Phe Asn Gln 
    1475                 1480                 1485             


Gln Lys  Lys Lys Phe Gly Gly  Gln Asp Ile Phe Met  Thr Glu Glu 
    1490                 1495                 1500             


Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys Leu Gly  Ser Lys Lys 
    1505                 1510                 1515             


Pro Gln  Lys Pro Ile Pro Arg  Pro Gly Asn Lys Phe  Gln Gly Met 
    1520                 1525                 1530             


Val Phe  Asp Phe Val Thr Arg  Gln Val Phe Asp Ile  Ser Ile Met 
    1535                 1540                 1545             


Ile Leu  Ile Cys Leu Asn Met  Val Thr Met Met Val  Glu Thr Asp 
    1550                 1555                 1560             


Asp Gln  Ser Glu Tyr Val Thr  Thr Ile Leu Ser Arg  Ile Asn Leu 
    1565                 1570                 1575             


Val Phe  Ile Val Leu Phe Thr  Gly Glu Cys Val Leu  Lys Leu Ile 
    1580                 1585                 1590             


Ser Leu  Arg His Tyr Tyr Phe  Thr Ile Gly Trp Asn  Ile Phe Asp 
    1595                 1600                 1605             


Phe Val  Val Val Ile Leu Ser  Ile Val Gly Met Phe  Leu Ala Glu 
    1610                 1615                 1620             


Leu Ile  Glu Lys Tyr Phe Val  Ser Pro Thr Leu Phe  Arg Val Ile 
    1625                 1630                 1635             


Arg Leu  Ala Arg Ile Gly Arg  Ile Leu Arg Leu Ile  Lys Gly Ala 
    1640                 1645                 1650             


Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu Met Met  Ser Leu Pro 
    1655                 1660                 1665             


Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe Leu Val  Met Phe Ile 
    1670                 1675                 1680             


Tyr Ala  Ile Phe Gly Met Ser  Asn Phe Ala Tyr Val  Lys Arg Glu 
    1685                 1690                 1695             


Val Gly  Ile Asp Asp Met Phe  Asn Phe Glu Thr Phe  Gly Asn Ser 
    1700                 1705                 1710             


Met Ile  Cys Leu Phe Gln Ile  Thr Thr Ser Ala Gly  Trp Asp Gly 
    1715                 1720                 1725             


Leu Leu  Ala Pro Ile Leu Asn  Ser Lys Pro Pro Asp  Cys Asp Pro 
    1730                 1735                 1740             


Asn Lys  Val Asn Pro Gly Ser  Ser Val Lys Gly Asp  Cys Gly Asn 
    1745                 1750                 1755             


Pro Ser  Val Gly Ile Phe Phe  Phe Val Ser Tyr Ile  Ile Ile Ser 
    1760                 1765                 1770             


Phe Leu  Val Val Val Asn Met  Tyr Ile Ala Val Ile  Leu Glu Asn 
    1775                 1780                 1785             


Phe Ser  Val Ala Thr Glu Glu  Ser Ala Glu Pro Leu  Ser Glu Asp 
    1790                 1795                 1800             


Asp Phe  Glu Met Phe Tyr Glu  Val Trp Glu Lys Phe  Asp Pro Asp 
    1805                 1810                 1815             


Ala Thr  Gln Phe Met Glu Phe  Glu Lys Leu Ser Gln  Phe Ala Ala 
    1820                 1825                 1830             


Ala Leu  Glu Pro Pro Leu Asn  Leu Pro Gln Pro Asn  Lys Leu Gln 
    1835                 1840                 1845             


Leu Ile  Ala Met Asp Leu Pro  Met Val Ser Gly Asp  Arg Ile His 
    1850                 1855                 1860             


Cys Leu  Asp Ile Leu Phe Ala  Phe Thr Lys Arg Val  Leu Gly Glu 
    1865                 1870                 1875             


Ser Gly  Glu Met Asp Ala Leu  Arg Ile Gln Met Glu  Glu Arg Phe 
    1880                 1885                 1890             


Met Ala  Ser Asn Pro Ser Lys  Val Ser Tyr Gln Pro  Ile Thr Thr 
    1895                 1900                 1905             


Thr Leu  Lys Arg Lys Gln Glu  Glu Val Ser Ala Val  Ile Ile Gln 
    1910                 1915                 1920             


Arg Ala  Tyr Arg Arg His Leu  Leu Lys Arg Thr Val  Lys Gln Ala 
    1925                 1930                 1935             


Ser Phe  Thr Tyr Asn Lys Asn  Lys Ile Lys Gly Gly  Ala Asn Leu 
    1940                 1945                 1950             


Leu Ile  Lys Glu Asp Met Ile  Ile Asp Arg Ile Asn  Glu Asn Ser 
    1955                 1960                 1965             


Ile Thr  Glu Lys Thr Asp Leu  Thr Met Ser Thr Ala  Ala Cys Pro 
    1970                 1975                 1980             


Pro Ser  Tyr Asp Arg Val Thr  Lys Pro Ile Val Glu  Lys His Glu 
    1985                 1990                 1995             


Gln Glu  Gly Lys Asp Glu Lys  Ala Lys Gly Lys 
    2000                 2005                 


<210> 3
<211> 2005
<212> PRT
<213> Homo sapiens

<400> 3
Met Ala Gln Ser Val Leu Val Pro Pro Gly Pro Asp Ser Phe Arg Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Gln Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Arg Pro Lys Gln Glu Arg Lys Asp Glu Asp Asp Glu Asn 
        35                  40                  45              


Gly Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Ser Leu Pro Phe 
    50                  55                  60                  


Ile Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Val Pro Leu Glu Asp 
65                  70                  75                  80  


Leu Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys 
                85                  90                  95      


Gly Lys Ala Ile Ser Arg Phe Ser Ala Thr Pro Ala Leu Tyr Ile Leu 
            100                 105                 110         


Thr Pro Phe Asn Pro Ile Arg Lys Leu Ala Ile Lys Ile Leu Val His 
        115                 120                 125             


Ser Leu Phe Asn Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val 
    130                 135                 140                 


Phe Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr 
145                 150                 155                 160 


Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Leu Ala 
                165                 170                 175     


Arg Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn 
            180                 185                 190         


Trp Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val 
        195                 200                 205             


Asp Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala 
    210                 215                 220                 


Leu Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala 
225                 230                 235                 240 


Leu Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val 
                245                 250                 255     


Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly 
            260                 265                 270         


Asn Leu Arg Asn Lys Cys Leu Gln Trp Pro Pro Asp Asn Ser Ser Phe 
        275                 280                 285             


Glu Ile Asn Ile Thr Ser Phe Phe Asn Asn Ser Leu Asp Gly Asn Gly 
    290                 295                 300                 


Thr Thr Phe Asn Arg Thr Val Ser Ile Phe Asn Trp Asp Glu Tyr Ile 
305                 310                 315                 320 


Glu Asp Lys Ser His Phe Tyr Phe Leu Glu Gly Gln Asn Asp Ala Leu 
                325                 330                 335     


Leu Cys Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Ile 
            340                 345                 350         


Cys Val Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp 
        355                 360                 365             


Thr Phe Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp 
    370                 375                 380                 


Phe Trp Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr 
385                 390                 395                 400 


Tyr Met Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu 
                405                 410                 415     


Ile Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn 
            420                 425                 430         


Gln Ala Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln 
        435                 440                 445             


Met Leu Glu Gln Leu Lys Lys Gln Gln Glu Glu Ala Gln Ala Ala Ala 
    450                 455                 460                 


Ala Ala Ala Ser Ala Glu Ser Arg Asp Phe Ser Gly Ala Gly Gly Ile 
465                 470                 475                 480 


Gly Val Phe Ser Glu Ser Ser Ser Val Ala Ser Lys Leu Ser Ser Lys 
                485                 490                 495     


Ser Glu Lys Glu Leu Lys Asn Arg Arg Lys Lys Lys Lys Gln Lys Glu 
            500                 505                 510         


Gln Ser Gly Glu Glu Glu Lys Asn Asp Arg Val Arg Lys Ser Glu Ser 
        515                 520                 525             


Glu Asp Ser Ile Arg Arg Lys Gly Phe Arg Phe Ser Leu Glu Gly Ser 
    530                 535                 540                 


Arg Leu Thr Tyr Glu Lys Arg Phe Ser Ser Pro His Gln Ser Leu Leu 
545                 550                 555                 560 


Ser Ile Arg Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Ala Ser 
                565                 570                 575     


Leu Phe Ser Phe Arg Gly Arg Ala Lys Asp Ile Gly Ser Glu Asn Asp 
            580                 585                 590         


Phe Ala Asp Asp Glu His Ser Thr Phe Glu Asp Asn Asp Ser Arg Arg 
        595                 600                 605             


Asp Ser Leu Phe Val Pro His Arg His Gly Glu Arg Arg His Ser Asn 
    610                 615                 620                 


Val Ser Gln Ala Ser Arg Ala Ser Arg Val Leu Pro Ile Leu Pro Met 
625                 630                 635                 640 


Asn Gly Lys Met His Ser Ala Val Asp Cys Asn Gly Val Val Ser Leu 
                645                 650                 655     


Val Gly Gly Pro Ser Thr Leu Thr Ser Ala Gly Gln Leu Leu Pro Glu 
            660                 665                 670         


Gly Thr Thr Thr Glu Thr Glu Ile Arg Lys Arg Arg Ser Ser Ser Tyr 
        675                 680                 685             


His Val Ser Met Asp Leu Leu Glu Asp Pro Thr Ser Arg Gln Arg Ala 
    690                 695                 700                 


Met Ser Ile Ala Ser Ile Leu Thr Asn Thr Met Glu Glu Leu Glu Glu 
705                 710                 715                 720 


Ser Arg Gln Lys Cys Pro Pro Cys Trp Tyr Lys Phe Ala Asn Met Cys 
                725                 730                 735     


Leu Ile Trp Asp Cys Cys Lys Pro Trp Leu Lys Val Lys His Leu Val 
            740                 745                 750         


Asn Leu Val Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile Cys 
        755                 760                 765             


Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His Tyr Pro Met Thr 
    770                 775                 780                 


Glu Gln Phe Ser Ser Val Leu Ser Val Gly Asn Leu Val Phe Thr Gly 
785                 790                 795                 800 


Ile Phe Thr Ala Glu Met Phe Leu Lys Ile Ile Ala Met Asp Pro Tyr 
                805                 810                 815     


Tyr Tyr Phe Gln Glu Gly Trp Asn Ile Phe Asp Gly Phe Ile Val Ser 
            820                 825                 830         


Leu Ser Leu Met Glu Leu Gly Leu Ala Asn Val Glu Gly Leu Ser Val 
        835                 840                 845             


Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp 
    850                 855                 860                 


Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala 
865                 870                 875                 880 


Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala 
                885                 890                 895     


Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys 
            900                 905                 910         


Lys Ile Ser Asn Asp Cys Glu Leu Pro Arg Trp His Met His Asp Phe 
        915                 920                 925             


Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp Ile 
    930                 935                 940                 


Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Thr Met Cys Leu 
945                 950                 955                 960 


Thr Val Phe Met Met Val Met Val Ile Gly Asn Leu Val Val Leu Asn 
                965                 970                 975     


Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu Ala 
            980                 985                 990         


Ala Thr Asp Asp Asp Asn Glu Met  Asn Asn Leu Gln Ile  Ala Val Gly 
        995                 1000                 1005             


Arg Met  Gln Lys Gly Ile Asp  Phe Val Lys Arg Lys  Ile Arg Glu 
    1010                 1015                 1020             


Phe Ile  Gln Lys Ala Phe Val  Arg Lys Gln Lys Ala  Leu Asp Glu 
    1025                 1030                 1035             


Ile Lys  Pro Leu Glu Asp Leu  Asn Asn Lys Lys Asp  Ser Cys Ile 
    1040                 1045                 1050             


Ser Asn  His Thr Thr Ile Glu  Ile Gly Lys Asp Leu  Asn Tyr Leu 
    1055                 1060                 1065             


Lys Asp  Gly Asn Gly Thr Thr  Ser Gly Ile Gly Ser  Ser Val Glu 
    1070                 1075                 1080             


Lys Tyr  Val Val Asp Glu Ser  Asp Tyr Met Ser Phe  Ile Asn Asn 
    1085                 1090                 1095             


Pro Ser  Leu Thr Val Thr Val  Pro Ile Ala Val Gly  Glu Ser Asp 
    1100                 1105                 1110             


Phe Glu  Asn Leu Asn Thr Glu  Glu Phe Ser Ser Glu  Ser Asp Met 
    1115                 1120                 1125             


Glu Glu  Ser Lys Glu Lys Leu  Asn Ala Thr Ser Ser  Ser Glu Gly 
    1130                 1135                 1140             


Ser Thr  Val Asp Ile Gly Ala  Pro Ala Glu Gly Glu  Gln Pro Glu 
    1145                 1150                 1155             


Val Glu  Pro Glu Glu Ser Leu  Glu Pro Glu Ala Cys  Phe Thr Glu 
    1160                 1165                 1170             


Asp Cys  Val Arg Lys Phe Lys  Cys Cys Gln Ile Ser  Ile Glu Glu 
    1175                 1180                 1185             


Gly Lys  Gly Lys Leu Trp Trp  Asn Leu Arg Lys Thr  Cys Tyr Lys 
    1190                 1195                 1200             


Ile Val  Glu His Asn Trp Phe  Glu Thr Phe Ile Val  Phe Met Ile 
    1205                 1210                 1215             


Leu Leu  Ser Ser Gly Ala Leu  Ala Phe Glu Asp Ile  Tyr Ile Glu 
    1220                 1225                 1230             


Gln Arg  Lys Thr Ile Lys Thr  Met Leu Glu Tyr Ala  Asp Lys Val 
    1235                 1240                 1245             


Phe Thr  Tyr Ile Phe Ile Leu  Glu Met Leu Leu Lys  Trp Val Ala 
    1250                 1255                 1260             


Tyr Gly  Phe Gln Val Tyr Phe  Thr Asn Ala Trp Cys  Trp Leu Asp 
    1265                 1270                 1275             


Phe Leu  Ile Val Asp Val Ser  Leu Val Ser Leu Thr  Ala Asn Ala 
    1280                 1285                 1290             


Leu Gly  Tyr Ser Glu Leu Gly  Ala Ile Lys Ser Leu  Arg Thr Leu 
    1295                 1300                 1305             


Arg Ala  Leu Arg Pro Leu Arg  Ala Leu Ser Arg Phe  Glu Gly Met 
    1310                 1315                 1320             


Arg Val  Val Val Asn Ala Leu  Leu Gly Ala Ile Pro  Ser Ile Met 
    1325                 1330                 1335             


Asn Val  Leu Leu Val Cys Leu  Ile Phe Trp Leu Ile  Phe Ser Ile 
    1340                 1345                 1350             


Met Gly  Val Asn Leu Phe Ala  Gly Lys Phe Tyr His  Cys Ile Asn 
    1355                 1360                 1365             


Tyr Thr  Thr Gly Glu Met Phe  Asp Val Ser Val Val  Asn Asn Tyr 
    1370                 1375                 1380             


Ser Glu  Cys Lys Ala Leu Ile  Glu Ser Asn Gln Thr  Ala Arg Trp 
    1385                 1390                 1395             


Lys Asn  Val Lys Val Asn Phe  Asp Asn Val Gly Leu  Gly Tyr Leu 
    1400                 1405                 1410             


Ser Leu  Leu Gln Val Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met 
    1415                 1420                 1425             


Tyr Ala  Ala Val Asp Ser Arg  Asn Val Glu Leu Gln  Pro Lys Tyr 
    1430                 1435                 1440             


Glu Asp  Asn Leu Tyr Met Tyr  Leu Tyr Phe Val Ile  Phe Ile Ile 
    1445                 1450                 1455             


Phe Gly  Ser Phe Phe Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile 
    1460                 1465                 1470             


Asp Asn  Phe Asn Gln Gln Lys  Lys Lys Phe Gly Gly  Gln Asp Ile 
    1475                 1480                 1485             


Phe Met  Thr Glu Glu Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys 
    1490                 1495                 1500             


Leu Gly  Ser Lys Lys Pro Gln  Lys Pro Ile Pro Arg  Pro Ala Asn 
    1505                 1510                 1515             


Lys Phe  Gln Gly Met Val Phe  Asp Phe Val Thr Lys  Gln Val Phe 
    1520                 1525                 1530             


Asp Ile  Ser Ile Met Ile Leu  Ile Cys Leu Asn Met  Val Thr Met 
    1535                 1540                 1545             


Met Val  Glu Thr Asp Asp Gln  Ser Gln Glu Met Thr  Asn Ile Leu 
    1550                 1555                 1560             


Tyr Trp  Ile Asn Leu Val Phe  Ile Val Leu Phe Thr  Gly Glu Cys 
    1565                 1570                 1575             


Val Leu  Lys Leu Ile Ser Leu  Arg Tyr Tyr Tyr Phe  Thr Ile Gly 
    1580                 1585                 1590             


Trp Asn  Ile Phe Asp Phe Val  Val Val Ile Leu Ser  Ile Val Gly 
    1595                 1600                 1605             


Met Phe  Leu Ala Glu Leu Ile  Glu Lys Tyr Phe Val  Ser Pro Thr 
    1610                 1615                 1620             


Leu Phe  Arg Val Ile Arg Leu  Ala Arg Ile Gly Arg  Ile Leu Arg 
    1625                 1630                 1635             


Leu Ile  Lys Gly Ala Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu 
    1640                 1645                 1650             


Met Met  Ser Leu Pro Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe 
    1655                 1660                 1665             


Leu Val  Met Phe Ile Tyr Ala  Ile Phe Gly Met Ser  Asn Phe Ala 
    1670                 1675                 1680             


Tyr Val  Lys Arg Glu Val Gly  Ile Asp Asp Met Phe  Asn Phe Glu 
    1685                 1690                 1695             


Thr Phe  Gly Asn Ser Met Ile  Cys Leu Phe Gln Ile  Thr Thr Ser 
    1700                 1705                 1710             


Ala Gly  Trp Asp Gly Leu Leu  Ala Pro Ile Leu Asn  Ser Gly Pro 
    1715                 1720                 1725             


Pro Asp  Cys Asp Pro Asp Lys  Asp His Pro Gly Ser  Ser Val Lys 
    1730                 1735                 1740             


Gly Asp  Cys Gly Asn Pro Ser  Val Gly Ile Phe Phe  Phe Val Ser 
    1745                 1750                 1755             


Tyr Ile  Ile Ile Ser Phe Leu  Val Val Val Asn Met  Tyr Ile Ala 
    1760                 1765                 1770             


Val Ile  Leu Glu Asn Phe Ser  Val Ala Thr Glu Glu  Ser Ala Glu 
    1775                 1780                 1785             


Pro Leu  Ser Glu Asp Asp Phe  Glu Met Phe Tyr Glu  Val Trp Glu 
    1790                 1795                 1800             


Lys Phe  Asp Pro Asp Ala Thr  Gln Phe Ile Glu Phe  Ala Lys Leu 
    1805                 1810                 1815             


Ser Asp  Phe Ala Asp Ala Leu  Asp Pro Pro Leu Leu  Ile Ala Lys 
    1820                 1825                 1830             


Pro Asn  Lys Val Gln Leu Ile  Ala Met Asp Leu Pro  Met Val Ser 
    1835                 1840                 1845             


Gly Asp  Arg Ile His Cys Leu  Asp Ile Leu Phe Ala  Phe Thr Lys 
    1850                 1855                 1860             


Arg Val  Leu Gly Glu Ser Gly  Glu Met Asp Ala Leu  Arg Ile Gln 
    1865                 1870                 1875             


Met Glu  Glu Arg Phe Met Ala  Ser Asn Pro Ser Lys  Val Ser Tyr 
    1880                 1885                 1890             


Glu Pro  Ile Thr Thr Thr Leu  Lys Arg Lys Gln Glu  Glu Val Ser 
    1895                 1900                 1905             


Ala Ile  Ile Ile Gln Arg Ala  Tyr Arg Arg Tyr Leu  Leu Lys Gln 
    1910                 1915                 1920             


Lys Val  Lys Lys Val Ser Ser  Ile Tyr Lys Lys Asp  Lys Gly Lys 
    1925                 1930                 1935             


Glu Cys  Asp Gly Thr Pro Ile  Lys Glu Asp Thr Leu  Ile Asp Lys 
    1940                 1945                 1950             


Leu Asn  Glu Asn Ser Thr Pro  Glu Lys Thr Asp Met  Thr Pro Ser 
    1955                 1960                 1965             


Thr Thr  Ser Pro Pro Ser Tyr  Asp Ser Val Thr Lys  Pro Glu Lys 
    1970                 1975                 1980             


Glu Lys  Phe Glu Lys Asp Lys  Ser Glu Lys Glu Asp  Lys Gly Lys 
    1985                 1990                 1995             


Asp Ile  Arg Glu Ser Lys Lys  
    2000                 2005 


<210> 4
<211> 2000
<212> PRT
<213> Homo sapiens

<400> 4
Met Ala Gln Ala Leu Leu Val Pro Pro Gly Pro Glu Ser Phe Arg Leu 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Ala Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Lys Pro Lys Lys Glu Gln Asp Asn Asp Asp Glu Asn Lys 
        35                  40                  45              


Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
    50                  55                  60                  


Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
65                  70                  75                  80  


Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Met Asn Lys Gly 
                85                  90                  95      


Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
            100                 105                 110         


Pro Leu Asn Pro Val Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
        115                 120                 125             


Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
    130                 135                 140                 


Met Thr Leu Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Leu Ala Arg 
                165                 170                 175     


Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
            180                 185                 190         


Leu Asp Phe Ser Val Ile Val Met Ala Tyr Val Thr Glu Phe Val Ser 
        195                 200                 205             


Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
    210                 215                 220                 


Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
225                 230                 235                 240 


Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                245                 250                 255     


Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
            260                 265                 270         


Leu Arg Asn Lys Cys Leu Gln Trp Pro Pro Ser Asp Ser Ala Phe Glu 
        275                 280                 285             


Thr Asn Thr Thr Ser Tyr Phe Asn Gly Thr Met Asp Ser Asn Gly Thr 
    290                 295                 300                 


Phe Val Asn Val Thr Met Ser Thr Phe Asn Trp Lys Asp Tyr Ile Gly 
305                 310                 315                 320 


Asp Asp Ser His Phe Tyr Val Leu Asp Gly Gln Lys Asp Pro Leu Leu 
                325                 330                 335     


Cys Gly Asn Gly Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Ile Cys 
            340                 345                 350         


Val Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr 
        355                 360                 365             


Phe Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Tyr 
    370                 375                 380                 


Trp Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr 
385                 390                 395                 400 


Met Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Val 
                405                 410                 415     


Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln 
            420                 425                 430         


Ala Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met 
        435                 440                 445             


Leu Glu Gln Leu Lys Lys Gln Gln Glu Glu Ala Gln Ala Val Ala Ala 
    450                 455                 460                 


Ala Ser Ala Ala Ser Arg Asp Phe Ser Gly Ile Gly Gly Leu Gly Glu 
465                 470                 475                 480 


Leu Leu Glu Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala 
                485                 490                 495     


Lys Glu Trp Arg Asn Arg Arg Lys Lys Arg Arg Gln Arg Glu His Leu 
            500                 505                 510         


Glu Gly Asn Asn Lys Gly Glu Arg Asp Ser Phe Pro Lys Ser Glu Ser 
        515                 520                 525             


Glu Asp Ser Val Lys Arg Ser Ser Phe Leu Phe Ser Met Asp Gly Asn 
    530                 535                 540                 


Arg Leu Thr Ser Asp Lys Lys Phe Cys Ser Pro His Gln Ser Leu Leu 
545                 550                 555                 560 


Ser Ile Arg Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Lys Thr Ser 
                565                 570                 575     


Ile Phe Ser Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp 
            580                 585                 590         


Phe Ala Asp Asp Glu His Ser Thr Phe Glu Asp Ser Glu Ser Arg Arg 
        595                 600                 605             


Asp Ser Leu Phe Val Pro His Arg His Gly Glu Arg Arg Asn Ser Asn 
    610                 615                 620                 


Val Ser Gln Ala Ser Met Ser Ser Arg Met Val Pro Gly Leu Pro Ala 
625                 630                 635                 640 


Asn Gly Lys Met His Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu 
                645                 650                 655     


Val Gly Gly Pro Ser Ala Leu Thr Ser Pro Thr Gly Gln Leu Pro Pro 
            660                 665                 670         


Glu Gly Thr Thr Thr Glu Thr Glu Val Arg Lys Arg Arg Leu Ser Ser 
        675                 680                 685             


Tyr Gln Ile Ser Met Glu Met Leu Glu Asp Ser Ser Gly Arg Gln Arg 
    690                 695                 700                 


Ala Val Ser Ile Ala Ser Ile Leu Thr Asn Thr Met Glu Glu Leu Glu 
705                 710                 715                 720 


Glu Ser Arg Gln Lys Cys Pro Pro Cys Trp Tyr Arg Phe Ala Asn Val 
                725                 730                 735     


Phe Leu Ile Trp Asp Cys Cys Asp Ala Trp Leu Lys Val Lys His Leu 
            740                 745                 750         


Val Asn Leu Ile Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile 
        755                 760                 765             


Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His Tyr Pro Met 
    770                 775                 780                 


Thr Glu Gln Phe Ser Ser Val Leu Thr Val Gly Asn Leu Val Phe Thr 
785                 790                 795                 800 


Gly Ile Phe Thr Ala Glu Met Val Leu Lys Ile Ile Ala Met Asp Pro 
                805                 810                 815     


Tyr Tyr Tyr Phe Gln Glu Gly Trp Asn Ile Phe Asp Gly Ile Ile Val 
            820                 825                 830         


Ser Leu Ser Leu Met Glu Leu Gly Leu Ser Asn Val Glu Gly Leu Ser 
        835                 840                 845             


Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser 
    850                 855                 860                 


Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly 
865                 870                 875                 880 


Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe 
                885                 890                 895     


Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val 
            900                 905                 910         


Cys Lys Ile Asn Asp Asp Cys Thr Leu Pro Arg Trp His Met Asn Asp 
        915                 920                 925             


Phe Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp 
    930                 935                 940                 


Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Thr Met Cys 
945                 950                 955                 960 


Leu Ile Val Phe Met Leu Val Met Val Ile Gly Asn Leu Val Val Leu 
                965                 970                 975     


Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu 
            980                 985                 990         


Ala Ala Thr Asp Asp Asp Asn Glu  Met Asn Asn Leu Gln  Ile Ala Val 
        995                 1000                 1005             


Gly Arg  Met Gln Lys Gly Ile  Asp Tyr Val Lys Asn  Lys Met Arg 
    1010                 1015                 1020             


Glu Cys  Phe Gln Lys Ala Phe  Phe Arg Lys Pro Lys  Val Ile Glu 
    1025                 1030                 1035             


Ile His  Glu Gly Asn Lys Ile  Asp Ser Cys Met Ser  Asn Asn Thr 
    1040                 1045                 1050             


Gly Ile  Glu Ile Ser Lys Glu  Leu Asn Tyr Leu Arg  Asp Gly Asn 
    1055                 1060                 1065             


Gly Thr  Thr Ser Gly Val Gly  Thr Gly Ser Ser Val  Glu Lys Tyr 
    1070                 1075                 1080             


Val Ile  Asp Glu Asn Asp Tyr  Met Ser Phe Ile Asn  Asn Pro Ser 
    1085                 1090                 1095             


Leu Thr  Val Thr Val Pro Ile  Ala Val Gly Glu Ser  Asp Phe Glu 
    1100                 1105                 1110             


Asn Leu  Asn Thr Glu Glu Phe  Ser Ser Glu Ser Glu  Leu Glu Glu 
    1115                 1120                 1125             


Ser Lys  Glu Lys Leu Asn Ala  Thr Ser Ser Ser Glu  Gly Ser Thr 
    1130                 1135                 1140             


Val Asp  Val Val Leu Pro Arg  Glu Gly Glu Gln Ala  Glu Thr Glu 
    1145                 1150                 1155             


Pro Glu  Glu Asp Leu Lys Pro  Glu Ala Cys Phe Thr  Glu Gly Cys 
    1160                 1165                 1170             


Ile Lys  Lys Phe Pro Phe Cys  Gln Val Ser Thr Glu  Glu Gly Lys 
    1175                 1180                 1185             


Gly Lys  Ile Trp Trp Asn Leu  Arg Lys Thr Cys Tyr  Ser Ile Val 
    1190                 1195                 1200             


Glu His  Asn Trp Phe Glu Thr  Phe Ile Val Phe Met  Ile Leu Leu 
    1205                 1210                 1215             


Ser Ser  Gly Ala Leu Ala Phe  Glu Asp Ile Tyr Ile  Glu Gln Arg 
    1220                 1225                 1230             


Lys Thr  Ile Lys Thr Met Leu  Glu Tyr Ala Asp Lys  Val Phe Thr 
    1235                 1240                 1245             


Tyr Ile  Phe Ile Leu Glu Met  Leu Leu Lys Trp Val  Ala Tyr Gly 
    1250                 1255                 1260             


Phe Gln  Thr Tyr Phe Thr Asn  Ala Trp Cys Trp Leu  Asp Phe Leu 
    1265                 1270                 1275             


Ile Val  Asp Val Ser Leu Val  Ser Leu Val Ala Asn  Ala Leu Gly 
    1280                 1285                 1290             


Tyr Ser  Glu Leu Gly Ala Ile  Lys Ser Leu Arg Thr  Leu Arg Ala 
    1295                 1300                 1305             


Leu Arg  Pro Leu Arg Ala Leu  Ser Arg Phe Glu Gly  Met Arg Val 
    1310                 1315                 1320             


Val Val  Asn Ala Leu Val Gly  Ala Ile Pro Ser Ile  Met Asn Val 
    1325                 1330                 1335             


Leu Leu  Val Cys Leu Ile Phe  Trp Leu Ile Phe Ser  Ile Met Gly 
    1340                 1345                 1350             


Val Asn  Leu Phe Ala Gly Lys  Phe Tyr His Cys Val  Asn Met Thr 
    1355                 1360                 1365             


Thr Gly  Asn Met Phe Asp Ile  Ser Asp Val Asn Asn  Leu Ser Asp 
    1370                 1375                 1380             


Cys Gln  Ala Leu Gly Lys Gln  Ala Arg Trp Lys Asn  Val Lys Val 
    1385                 1390                 1395             


Asn Phe  Asp Asn Val Gly Ala  Gly Tyr Leu Ala Leu  Leu Gln Val 
    1400                 1405                 1410             


Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met Tyr Ala  Ala Val Asp 
    1415                 1420                 1425             


Ser Arg  Asp Val Lys Leu Gln  Pro Val Tyr Glu Glu  Asn Leu Tyr 
    1430                 1435                 1440             


Met Tyr  Leu Tyr Phe Val Ile  Phe Ile Ile Phe Gly  Ser Phe Phe 
    1445                 1450                 1455             


Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile Asp Asn  Phe Asn Gln 
    1460                 1465                 1470             


Gln Lys  Lys Lys Phe Gly Gly  Gln Asp Ile Phe Met  Thr Glu Glu 
    1475                 1480                 1485             


Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys Leu Gly  Ser Lys Lys 
    1490                 1495                 1500             


Pro Gln  Lys Pro Ile Pro Arg  Pro Ala Asn Lys Phe  Gln Gly Met 
    1505                 1510                 1515             


Val Phe  Asp Phe Val Thr Arg  Gln Val Phe Asp Ile  Ser Ile Met 
    1520                 1525                 1530             


Ile Leu  Ile Cys Leu Asn Met  Val Thr Met Met Val  Glu Thr Asp 
    1535                 1540                 1545             


Asp Gln  Gly Lys Tyr Met Thr  Leu Val Leu Ser Arg  Ile Asn Leu 
    1550                 1555                 1560             


Val Phe  Ile Val Leu Phe Thr  Gly Glu Phe Val Leu  Lys Leu Val 
    1565                 1570                 1575             


Ser Leu  Arg His Tyr Tyr Phe  Thr Ile Gly Trp Asn  Ile Phe Asp 
    1580                 1585                 1590             


Phe Val  Val Val Ile Leu Ser  Ile Val Gly Met Phe  Leu Ala Glu 
    1595                 1600                 1605             


Met Ile  Glu Lys Tyr Phe Val  Ser Pro Thr Leu Phe  Arg Val Ile 
    1610                 1615                 1620             


Arg Leu  Ala Arg Ile Gly Arg  Ile Leu Arg Leu Ile  Lys Gly Ala 
    1625                 1630                 1635             


Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu Met Met  Ser Leu Pro 
    1640                 1645                 1650             


Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe Leu Val  Met Phe Ile 
    1655                 1660                 1665             


Tyr Ala  Ile Phe Gly Met Ser  Asn Phe Ala Tyr Val  Lys Lys Glu 
    1670                 1675                 1680             


Ala Gly  Ile Asp Asp Met Phe  Asn Phe Glu Thr Phe  Gly Asn Ser 
    1685                 1690                 1695             


Met Ile  Cys Leu Phe Gln Ile  Thr Thr Ser Ala Gly  Trp Asp Gly 
    1700                 1705                 1710             


Leu Leu  Ala Pro Ile Leu Asn  Ser Ala Pro Pro Asp  Cys Asp Pro 
    1715                 1720                 1725             


Asp Thr  Ile His Pro Gly Ser  Ser Val Lys Gly Asp  Cys Gly Asn 
    1730                 1735                 1740             


Pro Ser  Val Gly Ile Phe Phe  Phe Val Ser Tyr Ile  Ile Ile Ser 
    1745                 1750                 1755             


Phe Leu  Val Val Val Asn Met  Tyr Ile Ala Val Ile  Leu Glu Asn 
    1760                 1765                 1770             


Phe Ser  Val Ala Thr Glu Glu  Ser Ala Glu Pro Leu  Ser Glu Asp 
    1775                 1780                 1785             


Asp Phe  Glu Met Phe Tyr Glu  Val Trp Glu Lys Phe  Asp Pro Asp 
    1790                 1795                 1800             


Ala Thr  Gln Phe Ile Glu Phe  Ser Lys Leu Ser Asp  Phe Ala Ala 
    1805                 1810                 1815             


Ala Leu  Asp Pro Pro Leu Leu  Ile Ala Lys Pro Asn  Lys Val Gln 
    1820                 1825                 1830             


Leu Ile  Ala Met Asp Leu Pro  Met Val Ser Gly Asp  Arg Ile His 
    1835                 1840                 1845             


Cys Leu  Asp Ile Leu Phe Ala  Phe Thr Lys Arg Val  Leu Gly Glu 
    1850                 1855                 1860             


Ser Gly  Glu Met Asp Ala Leu  Arg Ile Gln Met Glu  Asp Arg Phe 
    1865                 1870                 1875             


Met Ala  Ser Asn Pro Ser Lys  Val Ser Tyr Glu Pro  Ile Thr Thr 
    1880                 1885                 1890             


Thr Leu  Lys Arg Lys Gln Glu  Glu Val Ser Ala Ala  Ile Ile Gln 
    1895                 1900                 1905             


Arg Asn  Phe Arg Cys Tyr Leu  Leu Lys Gln Arg Leu  Lys Asn Ile 
    1910                 1915                 1920             


Ser Ser  Asn Tyr Asn Lys Glu  Ala Ile Lys Gly Arg  Ile Asp Leu 
    1925                 1930                 1935             


Pro Ile  Lys Gln Asp Met Ile  Ile Asp Lys Leu Asn  Gly Asn Ser 
    1940                 1945                 1950             


Thr Pro  Glu Lys Thr Asp Gly  Ser Ser Ser Thr Thr  Ser Pro Pro 
    1955                 1960                 1965             


Ser Tyr  Asp Ser Val Thr Lys  Pro Asp Lys Glu Lys  Phe Glu Lys 
    1970                 1975                 1980             


Asp Lys  Pro Glu Lys Glu Ser  Lys Gly Lys Glu Val  Arg Glu Asn 
    1985                 1990                 1995             


Gln Lys  
    2000 


<210> 5
<211> 1836
<212> PRT
<213> Homo sapiens

<400> 5
Met Ala Arg Pro Ser Leu Cys Thr Leu Ala Arg Leu Gly Pro Glu Cys 
1               5                   10                  15      


Leu Arg Pro Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Gln Arg Ala 
            20                  25                  30          


Val Glu Glu Glu Ala Arg Leu Gln Arg Asn Lys Gln Met Glu Ile Glu 
        35                  40                  45              


Glu Pro Glu Arg Lys Pro Arg Ser Asp Leu Glu Ala Gly Lys Asn Leu 
    50                  55                  60                  


Pro Met Ile Tyr Gly Asp Pro Pro Pro Glu Val Ile Gly Ile Pro Leu 
65                  70                  75                  80  


Glu Asp Leu Asp Pro Tyr Tyr Ser Asn Lys Lys Thr Phe Ile Val Leu 
                85                  90                  95      


Asn Lys Gly Lys Ala Ile Phe Arg Phe Ser Ala Thr Pro Ala Leu Tyr 
            100                 105                 110         


Leu Leu Ser Pro Phe Ser Val Val Arg Arg Gly Ala Ile Lys Val Leu 
        115                 120                 125             


Ile His Ala Leu Phe Ser Met Phe Ile Met Ile Thr Ile Leu Thr Asn 
    130                 135                 140                 


Cys Val Phe Met Thr Met Ser Asp Pro Pro Pro Trp Ser Lys Asn Val 
145                 150                 155                 160 


Glu Tyr Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile 
                165                 170                 175     


Leu Ala Arg Gly Phe Cys Val Asp Asp Phe Thr Phe Leu Arg Asp Pro 
            180                 185                 190         


Trp Asn Trp Leu Asp Phe Ser Val Ile Met Met Ala Tyr Leu Thr Glu 
        195                 200                 205             


Phe Val Asp Leu Gly Asn Ile Ser Ala Leu Arg Thr Phe Arg Val Leu 
    210                 215                 220                 


Arg Ala Leu Lys Thr Ile Thr Val Ile Pro Gly Leu Lys Thr Ile Val 
225                 230                 235                 240 


Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu 
                245                 250                 255     


Thr Val Phe Cys Leu Ser Val Phe Ala Leu Val Gly Leu Gln Leu Phe 
            260                 265                 270         


Met Gly Asn Leu Arg Gln Lys Cys Val Arg Trp Pro Pro Pro Phe Asn 
        275                 280                 285             


Asp Thr Asn Thr Thr Trp Tyr Ser Asn Asp Thr Trp Tyr Gly Asn Asp 
    290                 295                 300                 


Thr Trp Tyr Gly Asn Glu Met Trp Tyr Gly Asn Asp Ser Trp Tyr Ala 
305                 310                 315                 320 


Asn Asp Thr Trp Asn Ser His Ala Ser Trp Ala Thr Asn Asp Thr Phe 
                325                 330                 335     


Asp Trp Asp Ala Tyr Ile Ser Asp Glu Gly Asn Phe Tyr Phe Leu Glu 
            340                 345                 350         


Gly Ser Asn Asp Ala Leu Leu Cys Gly Asn Ser Ser Asp Ala Gly His 
        355                 360                 365             


Cys Pro Lys Gly Tyr Glu Cys Ile Lys Thr Gly Arg Asn Pro Asn Tyr 
    370                 375                 380                 


Gly Tyr Thr Ser Tyr Asp Thr Phe Ser Trp Ala Phe Leu Ala Leu Phe 
385                 390                 395                 400 


Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Phe Gln Leu Thr Leu 
                405                 410                 415     


Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val Ile Ile Phe 
            420                 425                 430         


Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val Val Ala Met 
        435                 440                 445             


Ala Tyr Ala Glu Gln Asn Glu Ala Thr Leu Ala Glu Asp Lys Glu Lys 
    450                 455                 460                 


Glu Glu Glu Phe Gln Gln Met Leu Glu Lys Phe Lys Lys His Gln Glu 
465                 470                 475                 480 


Glu Leu Glu Lys Ala Lys Ala Ala Gln Ala Leu Glu Gly Gly Glu Ala 
                485                 490                 495     


Asp Gly Asp Pro Ala His Gly Lys Asp Cys Asn Gly Ser Leu Asp Thr 
            500                 505                 510         


Ser Gln Gly Glu Lys Gly Ala Pro Arg Gln Ser Gly Ser Gly Asp Ser 
        515                 520                 525             


Gly Ile Ser Asp Ala Met Glu Glu Leu Glu Glu Ala His Gln Lys Cys 
    530                 535                 540                 


Pro Pro Trp Trp Tyr Lys Cys Ala His Lys Val Leu Ile Trp Asp Cys 
545                 550                 555                 560 


Cys Ala Pro Trp Leu Lys Phe Lys Asn Ile Ile His Leu Ile Val Met 
                565                 570                 575     


Asp Pro Phe Val Asp Leu Gly Ile Thr Ile Cys Ile Val Leu Asn Thr 
            580                 585                 590         


Leu Phe Met Ala Met Glu His Tyr Pro Met Thr Glu His Phe Asp Asn 
        595                 600                 605             


Val Leu Thr Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu 
    610                 615                 620                 


Met Val Leu Lys Leu Ile Ala Met Asp Pro Tyr Glu Tyr Phe Gln Gln 
625                 630                 635                 640 


Gly Trp Asn Ile Phe Asp Ser Ile Ile Val Thr Leu Ser Leu Val Glu 
                645                 650                 655     


Leu Gly Leu Ala Asn Val Gln Gly Leu Ser Val Leu Arg Ser Phe Arg 
            660                 665                 670         


Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met 
        675                 680                 685             


Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr 
    690                 695                 700                 


Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln 
705                 710                 715                 720 


Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys Lys Ile Ala Leu Asp 
                725                 730                 735     


Cys Asn Leu Pro Arg Trp His Met His Asp Phe Phe His Ser Phe Leu 
            740                 745                 750         


Ile Val Phe Arg Ile Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp 
        755                 760                 765             


Cys Met Glu Val Ala Gly Gln Ala Met Cys Leu Thr Val Phe Leu Met 
    770                 775                 780                 


Val Met Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu 
785                 790                 795                 800 


Leu Leu Ser Ser Phe Ser Ala Asp Ser Leu Ala Ala Ser Asp Glu Asp 
                805                 810                 815     


Gly Glu Met Asn Asn Leu Gln Ile Ala Ile Gly Arg Ile Lys Leu Gly 
            820                 825                 830         


Ile Gly Phe Ala Lys Ala Phe Leu Leu Gly Leu Leu His Gly Lys Ile 
        835                 840                 845             


Leu Ser Pro Lys Asp Ile Met Leu Ser Leu Gly Glu Ala Asp Gly Ala 
    850                 855                 860                 


Gly Glu Ala Gly Glu Ala Gly Glu Thr Ala Pro Glu Asp Glu Lys Lys 
865                 870                 875                 880 


Glu Pro Pro Glu Glu Asp Leu Lys Lys Asp Asn His Ile Leu Asn His 
                885                 890                 895     


Met Gly Leu Ala Asp Gly Pro Pro Ser Ser Leu Glu Leu Asp His Leu 
            900                 905                 910         


Asn Phe Ile Asn Asn Pro Tyr Leu Thr Ile Gln Val Pro Ile Ala Ser 
        915                 920                 925             


Glu Glu Ser Asp Leu Glu Met Pro Thr Glu Glu Glu Thr Asp Thr Phe 
    930                 935                 940                 


Ser Glu Pro Glu Asp Ser Lys Lys Pro Pro Gln Pro Leu Tyr Asp Gly 
945                 950                 955                 960 


Asn Ser Ser Val Cys Ser Thr Ala Asp Tyr Lys Pro Pro Glu Glu Asp 
                965                 970                 975     


Pro Glu Glu Gln Ala Glu Glu Asn Pro Glu Gly Glu Gln Pro Glu Glu 
            980                 985                 990         


Cys Phe Thr Glu Ala Cys Val Gln  Arg Trp Pro Cys Leu  Tyr Val Asp 
        995                 1000                 1005             


Ile Ser  Gln Gly Arg Gly Lys  Lys Trp Trp Thr Leu  Arg Arg Ala 
    1010                 1015                 1020             


Cys Phe  Lys Ile Val Glu His  Asn Trp Phe Glu Thr  Phe Ile Val 
    1025                 1030                 1035             


Phe Met  Ile Leu Leu Ser Ser  Gly Ala Leu Ala Phe  Glu Asp Ile 
    1040                 1045                 1050             


Tyr Ile  Glu Gln Arg Arg Val  Ile Arg Thr Ile Leu  Glu Tyr Ala 
    1055                 1060                 1065             


Asp Lys  Val Phe Thr Tyr Ile  Phe Ile Met Glu Met  Leu Leu Lys 
    1070                 1075                 1080             


Trp Val  Ala Tyr Gly Phe Lys  Val Tyr Phe Thr Asn  Ala Trp Cys 
    1085                 1090                 1095             


Trp Leu  Asp Phe Leu Ile Val  Asp Val Ser Ile Ile  Ser Leu Val 
    1100                 1105                 1110             


Ala Asn  Trp Leu Gly Tyr Ser  Glu Leu Gly Pro Ile  Lys Ser Leu 
    1115                 1120                 1125             


Arg Thr  Leu Arg Ala Leu Arg  Pro Leu Arg Ala Leu  Ser Arg Phe 
    1130                 1135                 1140             


Glu Gly  Met Arg Val Val Val  Asn Ala Leu Leu Gly  Ala Ile Pro 
    1145                 1150                 1155             


Ser Ile  Met Asn Val Leu Leu  Val Cys Leu Ile Phe  Trp Leu Ile 
    1160                 1165                 1170             


Phe Ser  Ile Met Gly Val Asn  Leu Phe Ala Gly Lys  Phe Tyr Tyr 
    1175                 1180                 1185             


Cys Ile  Asn Thr Thr Thr Ser  Glu Arg Phe Asp Ile  Ser Glu Val 
    1190                 1195                 1200             


Asn Asn  Lys Ser Glu Cys Glu  Ser Leu Met His Thr  Gly Gln Val 
    1205                 1210                 1215             


Arg Trp  Leu Asn Val Lys Val  Asn Tyr Asp Asn Val  Gly Leu Gly 
    1220                 1225                 1230             


Tyr Leu  Ser Leu Leu Gln Val  Ala Thr Phe Lys Gly  Trp Met Asp 
    1235                 1240                 1245             


Ile Met  Tyr Ala Ala Val Asp  Ser Arg Glu Lys Glu  Glu Gln Pro 
    1250                 1255                 1260             


Gln Tyr  Glu Val Asn Leu Tyr  Met Tyr Leu Tyr Phe  Val Ile Phe 
    1265                 1270                 1275             


Ile Ile  Phe Gly Ser Phe Phe  Thr Leu Asn Leu Phe  Ile Gly Val 
    1280                 1285                 1290             


Ile Ile  Asp Asn Phe Asn Gln  Gln Lys Lys Lys Leu  Gly Gly Lys 
    1295                 1300                 1305             


Asp Ile  Phe Met Thr Glu Glu  Gln Lys Lys Tyr Tyr  Asn Ala Met 
    1310                 1315                 1320             


Lys Lys  Leu Gly Ser Lys Lys  Pro Gln Lys Pro Ile  Pro Arg Pro 
    1325                 1330                 1335             


Gln Asn  Lys Ile Gln Gly Met  Val Tyr Asp Leu Val  Thr Lys Gln 
    1340                 1345                 1350             


Ala Phe  Asp Ile Thr Ile Met  Ile Leu Ile Cys Leu  Asn Met Val 
    1355                 1360                 1365             


Thr Met  Met Val Glu Thr Asp  Asp Gln Ser Gln Leu  Lys Val Asp 
    1370                 1375                 1380             


Ile Leu  Tyr Asn Ile Asn Met  Ile Phe Ile Ile Ile  Phe Thr Gly 
    1385                 1390                 1395             


Glu Cys  Val Leu Lys Met Leu  Ala Leu Arg Gln Tyr  Tyr Phe Thr 
    1400                 1405                 1410             


Val Gly  Trp Asn Ile Phe Asp  Phe Val Val Val Ile  Leu Ser Ile 
    1415                 1420                 1425             


Val Gly  Leu Ala Leu Ser Asp  Leu Ile Gln Lys Tyr  Phe Val Ser 
    1430                 1435                 1440             


Pro Thr  Leu Phe Arg Val Ile  Arg Leu Ala Arg Ile  Gly Arg Val 
    1445                 1450                 1455             


Leu Arg  Leu Ile Arg Gly Ala  Lys Gly Ile Arg Thr  Leu Leu Phe 
    1460                 1465                 1470             


Ala Leu  Met Met Ser Leu Pro  Ala Leu Phe Asn Ile  Gly Leu Leu 
    1475                 1480                 1485             


Leu Phe  Leu Val Met Phe Ile  Tyr Ser Ile Phe Gly  Met Ser Asn 
    1490                 1495                 1500             


Phe Ala  Tyr Val Lys Lys Glu  Ser Gly Ile Asp Asp  Met Phe Asn 
    1505                 1510                 1515             


Phe Glu  Thr Phe Gly Asn Ser  Ile Ile Cys Leu Phe  Glu Ile Thr 
    1520                 1525                 1530             


Thr Ser  Ala Gly Trp Asp Gly  Leu Leu Asn Pro Ile  Leu Asn Ser 
    1535                 1540                 1545             


Gly Pro  Pro Asp Cys Asp Pro  Asn Leu Glu Asn Pro  Gly Thr Ser 
    1550                 1555                 1560             


Val Lys  Gly Asp Cys Gly Asn  Pro Ser Ile Gly Ile  Cys Phe Phe 
    1565                 1570                 1575             


Cys Ser  Tyr Ile Ile Ile Ser  Phe Leu Ile Val Val  Asn Met Tyr 
    1580                 1585                 1590             


Ile Ala  Ile Ile Leu Glu Asn  Phe Asn Val Ala Thr  Glu Glu Ser 
    1595                 1600                 1605             


Ser Glu  Pro Leu Gly Glu Asp  Asp Phe Glu Met Phe  Tyr Glu Thr 
    1610                 1615                 1620             


Trp Glu  Lys Phe Asp Pro Asp  Ala Thr Gln Phe Ile  Ala Tyr Ser 
    1625                 1630                 1635             


Arg Leu  Ser Asp Phe Val Asp  Thr Leu Gln Glu Pro  Leu Arg Ile 
    1640                 1645                 1650             


Ala Lys  Pro Asn Lys Ile Lys  Leu Ile Thr Leu Asp  Leu Pro Met 
    1655                 1660                 1665             


Val Pro  Gly Asp Lys Ile His  Cys Leu Asp Ile Leu  Phe Ala Leu 
    1670                 1675                 1680             


Thr Lys  Glu Val Leu Gly Asp  Ser Gly Glu Met Asp  Ala Leu Lys 
    1685                 1690                 1695             


Gln Thr  Met Glu Glu Lys Phe  Met Ala Ala Asn Pro  Ser Lys Val 
    1700                 1705                 1710             


Ser Tyr  Glu Pro Ile Thr Thr  Thr Leu Lys Arg Lys  His Glu Glu 
    1715                 1720                 1725             


Val Cys  Ala Ile Lys Ile Gln  Arg Ala Tyr Arg Arg  His Leu Leu 
    1730                 1735                 1740             


Gln Arg  Ser Met Lys Gln Ala  Ser Tyr Met Tyr Arg  His Ser His 
    1745                 1750                 1755             


Asp Gly  Ser Gly Asp Asp Ala  Pro Glu Lys Glu Gly  Leu Leu Ala 
    1760                 1765                 1770             


Asn Thr  Met Ser Lys Met Tyr  Gly His Glu Asn Gly  Asn Ser Ser 
    1775                 1780                 1785             


Ser Pro  Ser Pro Glu Glu Lys  Gly Glu Ala Gly Asp  Ala Gly Pro 
    1790                 1795                 1800             


Thr Met  Gly Leu Met Pro Ile  Ser Pro Ser Asp Thr  Ala Trp Pro 
    1805                 1810                 1815             


Pro Ala  Pro Pro Pro Gly Gln  Thr Val Arg Pro Gly  Val Lys Glu 
    1820                 1825                 1830             


Ser Leu  Val 
    1835     


<210> 6
<211> 2016
<212> PRT
<213> Homo sapiens

<400> 6
Met Ala Asn Phe Leu Leu Pro Arg Gly Thr Ser Ser Phe Arg Arg Phe 
1               5                   10                  15      


Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg Met Ala Glu Lys Gln 
            20                  25                  30          


Ala Arg Gly Ser Thr Thr Leu Gln Glu Ser Arg Glu Gly Leu Pro Glu 
        35                  40                  45              


Glu Glu Ala Pro Arg Pro Gln Leu Asp Leu Gln Ala Ser Lys Lys Leu 
    50                  55                  60                  


Pro Asp Leu Tyr Gly Asn Pro Pro Gln Glu Leu Ile Gly Glu Pro Leu 
65                  70                  75                  80  


Glu Asp Leu Asp Pro Phe Tyr Ser Thr Gln Lys Thr Phe Ile Val Leu 
                85                  90                  95      


Asn Lys Gly Lys Thr Ile Phe Arg Phe Ser Ala Thr Asn Ala Leu Tyr 
            100                 105                 110         


Val Leu Ser Pro Phe His Pro Ile Arg Arg Ala Ala Val Lys Ile Leu 
        115                 120                 125             


Val His Ser Leu Phe Asn Met Leu Ile Met Cys Thr Ile Leu Thr Asn 
    130                 135                 140                 


Cys Val Phe Met Ala Gln His Asp Pro Pro Pro Trp Thr Lys Tyr Val 
145                 150                 155                 160 


Glu Tyr Thr Phe Thr Ala Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile 
                165                 170                 175     


Leu Ala Arg Gly Phe Cys Leu His Ala Phe Thr Phe Leu Arg Asp Pro 
            180                 185                 190         


Trp Asn Trp Leu Asp Phe Ser Val Ile Ile Met Ala Tyr Thr Thr Glu 
        195                 200                 205             


Phe Val Asp Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu 
    210                 215                 220                 


Arg Ala Leu Lys Thr Ile Ser Val Ile Ser Gly Leu Lys Thr Ile Val 
225                 230                 235                 240 


Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ala Asp Val Met Val Leu 
                245                 250                 255     


Thr Val Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe 
            260                 265                 270         


Met Gly Asn Leu Arg His Lys Cys Val Arg Asn Phe Thr Ala Leu Asn 
        275                 280                 285             


Gly Thr Asn Gly Ser Val Glu Ala Asp Gly Leu Val Trp Glu Ser Leu 
    290                 295                 300                 


Asp Leu Tyr Leu Ser Asp Pro Glu Asn Tyr Leu Leu Lys Asn Gly Thr 
305                 310                 315                 320 


Ser Asp Val Leu Leu Cys Gly Asn Ser Ser Asp Ala Gly Thr Cys Pro 
                325                 330                 335     


Glu Gly Tyr Arg Cys Leu Lys Ala Gly Glu Asn Pro Asp His Gly Tyr 
            340                 345                 350         


Thr Ser Phe Asp Ser Phe Ala Trp Ala Phe Leu Ala Leu Phe Arg Leu 
        355                 360                 365             


Met Thr Gln Asp Cys Trp Glu Arg Leu Tyr Gln Gln Thr Leu Arg Ser 
    370                 375                 380                 


Ala Gly Lys Ile Tyr Met Ile Phe Phe Met Leu Val Ile Phe Leu Gly 
385                 390                 395                 400 


Ser Phe Tyr Leu Val Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr 
                405                 410                 415     


Glu Glu Gln Asn Gln Ala Thr Ile Ala Glu Thr Glu Glu Lys Glu Lys 
            420                 425                 430         


Arg Phe Gln Glu Ala Met Glu Met Leu Lys Lys Glu His Glu Ala Leu 
        435                 440                 445             


Thr Ile Arg Gly Val Asp Thr Val Ser Arg Ser Ser Leu Glu Met Ser 
    450                 455                 460                 


Pro Leu Ala Pro Val Asn Ser His Glu Arg Arg Ser Lys Arg Arg Lys 
465                 470                 475                 480 


Arg Met Ser Ser Gly Thr Glu Glu Cys Gly Glu Asp Arg Leu Pro Lys 
                485                 490                 495     


Ser Asp Ser Glu Asp Gly Pro Arg Ala Met Asn His Leu Ser Leu Thr 
            500                 505                 510         


Arg Gly Leu Ser Arg Thr Ser Met Lys Pro Arg Ser Ser Arg Gly Ser 
        515                 520                 525             


Ile Phe Thr Phe Arg Arg Arg Asp Leu Gly Ser Glu Ala Asp Phe Ala 
    530                 535                 540                 


Asp Asp Glu Asn Ser Thr Ala Gly Glu Ser Glu Ser His His Thr Ser 
545                 550                 555                 560 


Leu Leu Val Pro Trp Pro Leu Arg Arg Thr Ser Ala Gln Gly Gln Pro 
                565                 570                 575     


Ser Pro Gly Thr Ser Ala Pro Gly His Ala Leu His Gly Lys Lys Asn 
            580                 585                 590         


Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Leu Gly Ala Gly Asp 
        595                 600                 605             


Pro Glu Ala Thr Ser Pro Gly Ser His Leu Leu Arg Pro Val Met Leu 
    610                 615                 620                 


Glu His Pro Pro Asp Thr Thr Thr Pro Ser Glu Glu Pro Gly Gly Pro 
625                 630                 635                 640 


Gln Met Leu Thr Ser Gln Ala Pro Cys Val Asp Gly Phe Glu Glu Pro 
                645                 650                 655     


Gly Ala Arg Gln Arg Ala Leu Ser Ala Val Ser Val Leu Thr Ser Ala 
            660                 665                 670         


Leu Glu Glu Leu Glu Glu Ser Arg His Lys Cys Pro Pro Cys Trp Asn 
        675                 680                 685             


Arg Leu Ala Gln Arg Tyr Leu Ile Trp Glu Cys Cys Pro Leu Trp Met 
    690                 695                 700                 


Ser Ile Lys Gln Gly Val Lys Leu Val Val Met Asp Pro Phe Thr Asp 
705                 710                 715                 720 


Leu Thr Ile Thr Met Cys Ile Val Leu Asn Thr Leu Phe Met Ala Leu 
                725                 730                 735     


Glu His Tyr Asn Met Thr Ser Glu Phe Glu Glu Met Leu Gln Val Gly 
            740                 745                 750         


Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Thr Phe Lys Ile 
        755                 760                 765             


Ile Ala Leu Asp Pro Tyr Tyr Tyr Phe Gln Gln Gly Trp Asn Ile Phe 
    770                 775                 780                 


Asp Ser Ile Ile Val Ile Leu Ser Leu Met Glu Leu Gly Leu Ser Arg 
785                 790                 795                 800 


Met Ser Asn Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe 
                805                 810                 815     


Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Thr Leu Ile Lys Ile Ile 
            820                 825                 830         


Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile 
        835                 840                 845             


Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Asn 
    850                 855                 860                 


Tyr Ser Glu Leu Arg Asp Ser Asp Ser Gly Leu Leu Pro Arg Trp His 
865                 870                 875                 880 


Met Met Asp Phe Phe His Ala Phe Leu Ile Ile Phe Arg Ile Leu Cys 
                885                 890                 895     


Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val Ser Gly Gln 
            900                 905                 910         


Ser Leu Cys Leu Leu Val Phe Leu Leu Val Met Val Ile Gly Asn Leu 
        915                 920                 925             


Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ala 
    930                 935                 940                 


Asp Asn Leu Thr Ala Pro Asp Glu Asp Arg Glu Met Asn Asn Leu Gln 
945                 950                 955                 960 


Leu Ala Leu Ala Arg Ile Gln Arg Gly Leu Arg Phe Val Lys Arg Thr 
                965                 970                 975     


Thr Trp Asp Phe Cys Cys Gly Leu Leu Arg Gln Arg Pro Gln Lys Pro 
            980                 985                 990         


Ala Ala Leu Ala Ala Gln Gly Gln  Leu Pro Ser Cys Ile  Ala Thr Pro 
        995                 1000                 1005             


Tyr Ser  Pro Pro Pro Pro Glu  Thr Glu Lys Val Pro  Pro Thr Arg 
    1010                 1015                 1020             


Lys Glu  Thr Arg Phe Glu Glu  Gly Glu Gln Pro Gly  Gln Gly Thr 
    1025                 1030                 1035             


Pro Gly  Asp Pro Glu Pro Val  Cys Val Pro Ile Ala  Val Ala Glu 
    1040                 1045                 1050             


Ser Asp  Thr Asp Asp Gln Glu  Glu Asp Glu Glu Asn  Ser Leu Gly 
    1055                 1060                 1065             


Thr Glu  Glu Glu Ser Ser Lys  Gln Gln Glu Ser Gln  Pro Val Ser 
    1070                 1075                 1080             


Gly Gly  Pro Glu Ala Pro Pro  Asp Ser Arg Thr Trp  Ser Gln Val 
    1085                 1090                 1095             


Ser Ala  Thr Ala Ser Ser Glu  Ala Glu Ala Ser Ala  Ser Gln Ala 
    1100                 1105                 1110             


Asp Trp  Arg Gln Gln Trp Lys  Ala Glu Pro Gln Ala  Pro Gly Cys 
    1115                 1120                 1125             


Gly Glu  Thr Pro Glu Asp Ser  Cys Ser Glu Gly Ser  Thr Ala Asp 
    1130                 1135                 1140             


Met Thr  Asn Thr Ala Glu Leu  Leu Glu Gln Ile Pro  Asp Leu Gly 
    1145                 1150                 1155             


Gln Asp  Val Lys Asp Pro Glu  Asp Cys Phe Thr Glu  Gly Cys Val 
    1160                 1165                 1170             


Arg Arg  Cys Pro Cys Cys Ala  Val Asp Thr Thr Gln  Ala Pro Gly 
    1175                 1180                 1185             


Lys Val  Trp Trp Arg Leu Arg  Lys Thr Cys Tyr His  Ile Val Glu 
    1190                 1195                 1200             


His Ser  Trp Phe Glu Thr Phe  Ile Ile Phe Met Ile  Leu Leu Ser 
    1205                 1210                 1215             


Ser Gly  Ala Leu Ala Phe Glu  Asp Ile Tyr Leu Glu  Glu Arg Lys 
    1220                 1225                 1230             


Thr Ile  Lys Val Leu Leu Glu  Tyr Ala Asp Lys Met  Phe Thr Tyr 
    1235                 1240                 1245             


Val Phe  Val Leu Glu Met Leu  Leu Lys Trp Val Ala  Tyr Gly Phe 
    1250                 1255                 1260             


Lys Lys  Tyr Phe Thr Asn Ala  Trp Cys Trp Leu Asp  Phe Leu Ile 
    1265                 1270                 1275             


Val Asp  Val Ser Leu Val Ser  Leu Val Ala Asn Thr  Leu Gly Phe 
    1280                 1285                 1290             


Ala Glu  Met Gly Pro Ile Lys  Ser Leu Arg Thr Leu  Arg Ala Leu 
    1295                 1300                 1305             


Arg Pro  Leu Arg Ala Leu Ser  Arg Phe Glu Gly Met  Arg Val Val 
    1310                 1315                 1320             


Val Asn  Ala Leu Val Gly Ala  Ile Pro Ser Ile Met  Asn Val Leu 
    1325                 1330                 1335             


Leu Val  Cys Leu Ile Phe Trp  Leu Ile Phe Ser Ile  Met Gly Val 
    1340                 1345                 1350             


Asn Leu  Phe Ala Gly Lys Phe  Gly Arg Cys Ile Asn  Gln Thr Glu 
    1355                 1360                 1365             


Gly Asp  Leu Pro Leu Asn Tyr  Thr Ile Val Asn Asn  Lys Ser Gln 
    1370                 1375                 1380             


Cys Glu  Ser Leu Asn Leu Thr  Gly Glu Leu Tyr Trp  Thr Lys Val 
    1385                 1390                 1395             


Lys Val  Asn Phe Asp Asn Val  Gly Ala Gly Tyr Leu  Ala Leu Leu 
    1400                 1405                 1410             


Gln Val  Ala Thr Phe Lys Gly  Trp Met Asp Ile Met  Tyr Ala Ala 
    1415                 1420                 1425             


Val Asp  Ser Arg Gly Tyr Glu  Glu Gln Pro Gln Trp  Glu Tyr Asn 
    1430                 1435                 1440             


Leu Tyr  Met Tyr Ile Tyr Phe  Val Ile Phe Ile Ile  Phe Gly Ser 
    1445                 1450                 1455             


Phe Phe  Thr Leu Asn Leu Phe  Ile Gly Val Ile Ile  Asp Asn Phe 
    1460                 1465                 1470             


Asn Gln  Gln Lys Lys Lys Leu  Gly Gly Gln Asp Ile  Phe Met Thr 
    1475                 1480                 1485             


Glu Glu  Gln Lys Lys Tyr Tyr  Asn Ala Met Lys Lys  Leu Gly Ser 
    1490                 1495                 1500             


Lys Lys  Pro Gln Lys Pro Ile  Pro Arg Pro Leu Asn  Lys Tyr Gln 
    1505                 1510                 1515             


Gly Phe  Ile Phe Asp Ile Val  Thr Lys Gln Ala Phe  Asp Val Thr 
    1520                 1525                 1530             


Ile Met  Phe Leu Ile Cys Leu  Asn Met Val Thr Met  Met Val Glu 
    1535                 1540                 1545             


Thr Asp  Asp Gln Ser Pro Glu  Lys Ile Asn Ile Leu  Ala Lys Ile 
    1550                 1555                 1560             


Asn Leu  Leu Phe Val Ala Ile  Phe Thr Gly Glu Cys  Ile Val Lys 
    1565                 1570                 1575             


Leu Ala  Ala Leu Arg His Tyr  Tyr Phe Thr Asn Ser  Trp Asn Ile 
    1580                 1585                 1590             


Phe Asp  Phe Val Val Val Ile  Leu Ser Ile Val Gly  Thr Val Leu 
    1595                 1600                 1605             


Ser Asp  Ile Ile Gln Lys Tyr  Phe Phe Ser Pro Thr  Leu Phe Arg 
    1610                 1615                 1620             


Val Ile  Arg Leu Ala Arg Ile  Gly Arg Ile Leu Arg  Leu Ile Arg 
    1625                 1630                 1635             


Gly Ala  Lys Gly Ile Arg Thr  Leu Leu Phe Ala Leu  Met Met Ser 
    1640                 1645                 1650             


Leu Pro  Ala Leu Phe Asn Ile  Gly Leu Leu Leu Phe  Leu Val Met 
    1655                 1660                 1665             


Phe Ile  Tyr Ser Ile Phe Gly  Met Ala Asn Phe Ala  Tyr Val Lys 
    1670                 1675                 1680             


Trp Glu  Ala Gly Ile Asp Asp  Met Phe Asn Phe Gln  Thr Phe Ala 
    1685                 1690                 1695             


Asn Ser  Met Leu Cys Leu Phe  Gln Ile Thr Thr Ser  Ala Gly Trp 
    1700                 1705                 1710             


Asp Gly  Leu Leu Ser Pro Ile  Leu Asn Thr Gly Pro  Pro Tyr Cys 
    1715                 1720                 1725             


Asp Pro  Thr Leu Pro Asn Ser  Asn Gly Ser Arg Gly  Asp Cys Gly 
    1730                 1735                 1740             


Ser Pro  Ala Val Gly Ile Leu  Phe Phe Thr Thr Tyr  Ile Ile Ile 
    1745                 1750                 1755             


Ser Phe  Leu Ile Val Val Asn  Met Tyr Ile Ala Ile  Ile Leu Glu 
    1760                 1765                 1770             


Asn Phe  Ser Val Ala Thr Glu  Glu Ser Thr Glu Pro  Leu Ser Glu 
    1775                 1780                 1785             


Asp Asp  Phe Asp Met Phe Tyr  Glu Ile Trp Glu Lys  Phe Asp Pro 
    1790                 1795                 1800             


Glu Ala  Thr Gln Phe Ile Glu  Tyr Ser Val Leu Ser  Asp Phe Ala 
    1805                 1810                 1815             


Asp Ala  Leu Ser Glu Pro Leu  Arg Ile Ala Lys Pro  Asn Gln Ile 
    1820                 1825                 1830             


Ser Leu  Ile Asn Met Asp Leu  Pro Met Val Ser Gly  Asp Arg Ile 
    1835                 1840                 1845             


His Cys  Met Asp Ile Leu Phe  Ala Phe Thr Lys Arg  Val Leu Gly 
    1850                 1855                 1860             


Glu Ser  Gly Glu Met Asp Ala  Leu Lys Ile Gln Met  Glu Glu Lys 
    1865                 1870                 1875             


Phe Met  Ala Ala Asn Pro Ser  Lys Ile Ser Tyr Glu  Pro Ile Thr 
    1880                 1885                 1890             


Thr Thr  Leu Arg Arg Lys His  Glu Glu Val Ser Ala  Met Val Ile 
    1895                 1900                 1905             


Gln Arg  Ala Phe Arg Arg His  Leu Leu Gln Arg Ser  Leu Lys His 
    1910                 1915                 1920             


Ala Ser  Phe Leu Phe Arg Gln  Gln Ala Gly Ser Gly  Leu Ser Glu 
    1925                 1930                 1935             


Glu Asp  Ala Pro Glu Arg Glu  Gly Leu Ile Ala Tyr  Val Met Ser 
    1940                 1945                 1950             


Glu Asn  Phe Ser Arg Pro Leu  Gly Pro Pro Ser Ser  Ser Ser Ile 
    1955                 1960                 1965             


Ser Ser  Thr Ser Phe Pro Pro  Ser Tyr Asp Ser Val  Thr Arg Ala 
    1970                 1975                 1980             


Thr Ser  Asp Asn Leu Gln Val  Arg Gly Ser Asp Tyr  Ser His Ser 
    1985                 1990                 1995             


Glu Asp  Leu Ala Asp Phe Pro  Pro Ser Pro Asp Arg  Asp Arg Glu 
    2000                 2005                 2010             


Ser Ile  Val 
    2015     


<210> 7
<211> 1980
<212> PRT
<213> Homo sapiens

<400> 7
Met Ala Ala Arg Leu Leu Ala Pro Pro Gly Pro Asp Ser Phe Lys Pro 
1               5                   10                  15      


Phe Thr Pro Glu Ser Leu Ala Asn Ile Glu Arg Arg Ile Ala Glu Ser 
            20                  25                  30          


Lys Leu Lys Lys Pro Pro Lys Ala Asp Gly Ser His Arg Glu Asp Asp 
        35                  40                  45              


Glu Asp Ser Lys Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Ser 
    50                  55                  60                  


Leu Pro Phe Ile Tyr Gly Asp Ile Pro Gln Gly Leu Val Ala Val Pro 
65                  70                  75                  80  


Leu Glu Asp Phe Asp Pro Tyr Tyr Leu Thr Gln Lys Thr Phe Val Val 
                85                  90                  95      


Leu Asn Arg Gly Lys Thr Leu Phe Arg Phe Ser Ala Thr Pro Ala Leu 
            100                 105                 110         


Tyr Ile Leu Ser Pro Phe Asn Leu Ile Arg Arg Ile Ala Ile Lys Ile 
        115                 120                 125             


Leu Ile His Ser Val Phe Ser Met Ile Ile Met Cys Thr Ile Leu Thr 
    130                 135                 140                 


Asn Cys Val Phe Met Thr Phe Ser Asn Pro Pro Asp Trp Ser Lys Asn 
145                 150                 155                 160 


Val Glu Tyr Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys 
                165                 170                 175     


Ile Ile Ala Arg Gly Phe Cys Ile Asp Gly Phe Thr Phe Leu Arg Asp 
            180                 185                 190         


Pro Trp Asn Trp Leu Asp Phe Ser Val Ile Met Met Ala Tyr Ile Thr 
        195                 200                 205             


Glu Phe Val Asn Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val 
    210                 215                 220                 


Leu Arg Ala Leu Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile 
225                 230                 235                 240 


Val Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile 
                245                 250                 255     


Leu Thr Val Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu 
            260                 265                 270         


Phe Met Gly Asn Leu Arg Asn Lys Cys Val Val Trp Pro Ile Asn Phe 
        275                 280                 285             


Asn Glu Ser Tyr Leu Glu Asn Gly Thr Lys Gly Phe Asp Trp Glu Glu 
    290                 295                 300                 


Tyr Ile Asn Asn Lys Thr Asn Phe Tyr Thr Val Pro Gly Met Leu Glu 
305                 310                 315                 320 


Pro Leu Leu Cys Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly 
                325                 330                 335     


Tyr Gln Cys Met Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser 
            340                 345                 350         


Phe Asp Thr Phe Ser Trp Ala Phe Leu Ala Leu Phe Arg Leu Met Thr 
        355                 360                 365             


Gln Asp Tyr Trp Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly 
    370                 375                 380                 


Lys Thr Tyr Met Ile Phe Phe Val Leu Val Ile Phe Val Gly Ser Phe 
385                 390                 395                 400 


Tyr Leu Val Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu 
                405                 410                 415     


Gln Asn Gln Ala Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe 
            420                 425                 430         


Lys Ala Met Leu Glu Gln Leu Lys Lys Gln Gln Glu Glu Ala Gln Ala 
        435                 440                 445             


Ala Ala Met Ala Thr Ser Ala Gly Thr Val Ser Glu Asp Ala Ile Glu 
    450                 455                 460                 


Glu Glu Gly Glu Glu Gly Gly Gly Ser Pro Arg Ser Ser Ser Glu Ile 
465                 470                 475                 480 


Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg Lys 
                485                 490                 495     


Lys Arg Lys Gln Lys Glu Leu Ser Glu Gly Glu Glu Lys Gly Asp Pro 
            500                 505                 510         


Glu Lys Val Phe Lys Ser Glu Ser Glu Asp Gly Met Arg Arg Lys Ala 
        515                 520                 525             


Phe Arg Leu Pro Asp Asn Arg Ile Gly Arg Lys Phe Ser Ile Met Asn 
    530                 535                 540                 


Gln Ser Leu Leu Ser Ile Pro Gly Ser Pro Phe Leu Ser Arg His Asn 
545                 550                 555                 560 


Ser Lys Ser Ser Ile Phe Ser Phe Arg Gly Pro Gly Arg Phe Arg Asp 
                565                 570                 575     


Pro Gly Ser Glu Asn Glu Phe Ala Asp Asp Glu His Ser Thr Val Glu 
            580                 585                 590         


Glu Ser Glu Gly Arg Arg Asp Ser Leu Phe Ile Pro Ile Arg Ala Arg 
        595                 600                 605             


Glu Arg Arg Ser Ser Tyr Ser Gly Tyr Ser Gly Tyr Ser Gln Gly Ser 
    610                 615                 620                 


Arg Ser Ser Arg Ile Phe Pro Ser Leu Arg Arg Ser Val Lys Arg Asn 
625                 630                 635                 640 


Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Ile Gly Gly Pro Gly 
                645                 650                 655     


Ser His Ile Gly Gly Arg Leu Leu Pro Glu Ala Thr Thr Glu Val Glu 
            660                 665                 670         


Ile Lys Lys Lys Gly Pro Gly Ser Leu Leu Val Ser Met Asp Gln Leu 
        675                 680                 685             


Ala Ser Tyr Gly Arg Lys Asp Arg Ile Asn Ser Ile Met Ser Val Val 
    690                 695                 700                 


Thr Asn Thr Leu Val Glu Glu Leu Glu Glu Ser Gln Arg Lys Cys Pro 
705                 710                 715                 720 


Pro Cys Trp Tyr Lys Phe Ala Asn Thr Phe Leu Ile Trp Glu Cys His 
                725                 730                 735     


Pro Tyr Trp Ile Lys Leu Lys Glu Ile Val Asn Leu Ile Val Met Asp 
            740                 745                 750         


Pro Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu 
        755                 760                 765             


Phe Met Ala Met Glu His His Pro Met Thr Pro Gln Phe Glu His Val 
    770                 775                 780                 


Leu Ala Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met 
785                 790                 795                 800 


Phe Leu Lys Leu Ile Ala Met Asp Pro Tyr Tyr Tyr Phe Gln Glu Gly 
                805                 810                 815     


Trp Asn Ile Phe Asp Gly Phe Ile Val Ser Leu Ser Leu Met Glu Leu 
            820                 825                 830         


Ser Leu Ala Asp Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu 
        835                 840                 845             


Leu Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu 
    850                 855                 860                 


Ile Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu 
865                 870                 875                 880 


Val Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu 
                885                 890                 895     


Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys Lys Ile Asn Gln Asp Cys 
            900                 905                 910         


Glu Leu Pro Arg Trp His Met His Asp Phe Phe His Ser Phe Leu Ile 
        915                 920                 925             


Val Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys 
    930                 935                 940                 


Met Glu Val Ala Gly Gln Ala Met Cys Leu Ile Val Phe Met Met Val 
945                 950                 955                 960 


Met Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu 
                965                 970                 975     


Leu Ser Ser Phe Ser Ala Asp Asn Leu Ala Ala Thr Asp Asp Asp Gly 
            980                 985                 990         


Glu Met Asn Asn Leu Gln Ile Ser  Val Ile Arg Ile Lys  Lys Gly Val 
        995                 1000                 1005             


Ala Trp  Thr Lys Leu Lys Val  His Ala Phe Met Gln  Ala His Phe 
    1010                 1015                 1020             


Lys Gln  Arg Glu Ala Asp Glu  Val Lys Pro Leu Asp  Glu Leu Tyr 
    1025                 1030                 1035             


Glu Lys  Lys Ala Asn Cys Ile  Ala Asn His Thr Gly  Ala Asp Ile 
    1040                 1045                 1050             


His Arg  Asn Gly Asp Phe Gln  Lys Asn Gly Asn Gly  Thr Thr Ser 
    1055                 1060                 1065             


Gly Ile  Gly Ser Ser Val Glu  Lys Tyr Ile Ile Asp  Glu Asp His 
    1070                 1075                 1080             


Met Ser  Phe Ile Asn Asn Pro  Asn Leu Thr Val Arg  Val Pro Ile 
    1085                 1090                 1095             


Ala Val  Gly Glu Ser Asp Phe  Glu Asn Leu Asn Thr  Glu Asp Val 
    1100                 1105                 1110             


Ser Ser  Glu Ser Asp Pro Glu  Gly Ser Lys Asp Lys  Leu Asp Asp 
    1115                 1120                 1125             


Thr Ser  Ser Ser Glu Gly Ser  Thr Ile Asp Ile Lys  Pro Glu Val 
    1130                 1135                 1140             


Glu Glu  Val Pro Val Glu Gln  Pro Glu Glu Tyr Leu  Asp Pro Asp 
    1145                 1150                 1155             


Ala Cys  Phe Thr Glu Gly Cys  Val Gln Arg Phe Lys  Cys Cys Gln 
    1160                 1165                 1170             


Val Asn  Ile Glu Glu Gly Leu  Gly Lys Ser Trp Trp  Ile Leu Arg 
    1175                 1180                 1185             


Lys Thr  Cys Phe Leu Ile Val  Glu His Asn Trp Phe  Glu Thr Phe 
    1190                 1195                 1200             


Ile Ile  Phe Met Ile Leu Leu  Ser Ser Gly Ala Leu  Ala Phe Glu 
    1205                 1210                 1215             


Asp Ile  Tyr Ile Glu Gln Arg  Lys Thr Ile Arg Thr  Ile Leu Glu 
    1220                 1225                 1230             


Tyr Ala  Asp Lys Val Phe Thr  Tyr Ile Phe Ile Leu  Glu Met Leu 
    1235                 1240                 1245             


Leu Lys  Trp Thr Ala Tyr Gly  Phe Val Lys Phe Phe  Thr Asn Ala 
    1250                 1255                 1260             


Trp Cys  Trp Leu Asp Phe Leu  Ile Val Ala Val Ser  Leu Val Ser 
    1265                 1270                 1275             


Leu Ile  Ala Asn Ala Leu Gly  Tyr Ser Glu Leu Gly  Ala Ile Lys 
    1280                 1285                 1290             


Ser Leu  Arg Thr Leu Arg Ala  Leu Arg Pro Leu Arg  Ala Leu Ser 
    1295                 1300                 1305             


Arg Phe  Glu Gly Met Arg Val  Val Val Asn Ala Leu  Val Gly Ala 
    1310                 1315                 1320             


Ile Pro  Ser Ile Met Asn Val  Leu Leu Val Cys Leu  Ile Phe Trp 
    1325                 1330                 1335             


Leu Ile  Phe Ser Ile Met Gly  Val Asn Leu Phe Ala  Gly Lys Tyr 
    1340                 1345                 1350             


His Tyr  Cys Phe Asn Glu Thr  Ser Glu Ile Arg Phe  Glu Ile Glu 
    1355                 1360                 1365             


Asp Val  Asn Asn Lys Thr Glu  Cys Glu Lys Leu Met  Glu Gly Asn 
    1370                 1375                 1380             


Asn Thr  Glu Ile Arg Trp Lys  Asn Val Lys Ile Asn  Phe Asp Asn 
    1385                 1390                 1395             


Val Gly  Ala Gly Tyr Leu Ala  Leu Leu Gln Val Ala  Thr Phe Lys 
    1400                 1405                 1410             


Gly Trp  Met Asp Ile Met Tyr  Ala Ala Val Asp Ser  Arg Lys Pro 
    1415                 1420                 1425             


Asp Glu  Gln Pro Lys Tyr Glu  Asp Asn Ile Tyr Met  Tyr Ile Tyr 
    1430                 1435                 1440             


Phe Val  Ile Phe Ile Ile Phe  Gly Ser Phe Phe Thr  Leu Asn Leu 
    1445                 1450                 1455             


Phe Ile  Gly Val Ile Ile Asp  Asn Phe Asn Gln Gln  Lys Lys Lys 
    1460                 1465                 1470             


Phe Gly  Gly Gln Asp Ile Phe  Met Thr Glu Glu Gln  Lys Lys Tyr 
    1475                 1480                 1485             


Tyr Asn  Ala Met Lys Lys Leu  Gly Ser Lys Lys Pro  Gln Lys Pro 
    1490                 1495                 1500             


Ile Pro  Arg Pro Leu Asn Lys  Ile Gln Gly Ile Val  Phe Asp Phe 
    1505                 1510                 1515             


Val Thr  Gln Gln Ala Phe Asp  Ile Val Ile Met Met  Leu Ile Cys 
    1520                 1525                 1530             


Leu Asn  Met Val Thr Met Met  Val Glu Thr Asp Thr  Gln Ser Lys 
    1535                 1540                 1545             


Gln Met  Glu Asn Ile Leu Tyr  Trp Ile Asn Leu Val  Phe Val Ile 
    1550                 1555                 1560             


Phe Phe  Thr Cys Glu Cys Val  Leu Lys Met Phe Ala  Leu Arg His 
    1565                 1570                 1575             


Tyr Tyr  Phe Thr Ile Gly Trp  Asn Ile Phe Asp Phe  Val Val Val 
    1580                 1585                 1590             


Ile Leu  Ser Ile Val Gly Met  Phe Leu Ala Asp Ile  Ile Glu Lys 
    1595                 1600                 1605             


Tyr Phe  Val Ser Pro Thr Leu  Phe Arg Val Ile Arg  Leu Ala Arg 
    1610                 1615                 1620             


Ile Gly  Arg Ile Leu Arg Leu  Ile Lys Gly Ala Lys  Gly Ile Arg 
    1625                 1630                 1635             


Thr Leu  Leu Phe Ala Leu Met  Met Ser Leu Pro Ala  Leu Phe Asn 
    1640                 1645                 1650             


Ile Gly  Leu Leu Leu Phe Leu  Val Met Phe Ile Phe  Ser Ile Phe 
    1655                 1660                 1665             


Gly Met  Ser Asn Phe Ala Tyr  Val Lys His Glu Ala  Gly Ile Asp 
    1670                 1675                 1680             


Asp Met  Phe Asn Phe Glu Thr  Phe Gly Asn Ser Met  Ile Cys Leu 
    1685                 1690                 1695             


Phe Gln  Ile Thr Thr Ser Ala  Gly Trp Asp Gly Leu  Leu Leu Pro 
    1700                 1705                 1710             


Ile Leu  Asn Arg Pro Pro Asp  Cys Ser Leu Asp Lys  Glu His Pro 
    1715                 1720                 1725             


Gly Ser  Gly Phe Lys Gly Asp  Cys Gly Asn Pro Ser  Val Gly Ile 
    1730                 1735                 1740             


Phe Phe  Phe Val Ser Tyr Ile  Ile Ile Ser Phe Leu  Ile Val Val 
    1745                 1750                 1755             


Asn Met  Tyr Ile Ala Ile Ile  Leu Glu Asn Phe Ser  Val Ala Thr 
    1760                 1765                 1770             


Glu Glu  Ser Ala Asp Pro Leu  Ser Glu Asp Asp Phe  Glu Thr Phe 
    1775                 1780                 1785             


Tyr Glu  Ile Trp Glu Lys Phe  Asp Pro Asp Ala Thr  Gln Phe Ile 
    1790                 1795                 1800             


Glu Tyr  Cys Lys Leu Ala Asp  Phe Ala Asp Ala Leu  Glu His Pro 
    1805                 1810                 1815             


Leu Arg  Val Pro Lys Pro Asn  Thr Ile Glu Leu Ile  Ala Met Asp 
    1820                 1825                 1830             


Leu Pro  Met Val Ser Gly Asp  Arg Ile His Cys Leu  Asp Ile Leu 
    1835                 1840                 1845             


Phe Ala  Phe Thr Lys Arg Val  Leu Gly Asp Ser Gly  Glu Leu Asp 
    1850                 1855                 1860             


Ile Leu  Arg Gln Gln Met Glu  Glu Arg Phe Val Ala  Ser Asn Pro 
    1865                 1870                 1875             


Ser Lys  Val Ser Tyr Glu Pro  Ile Thr Thr Thr Leu  Arg Arg Lys 
    1880                 1885                 1890             


Gln Glu  Glu Val Ser Ala Val  Val Leu Gln Arg Ala  Tyr Arg Gly 
    1895                 1900                 1905             


His Leu  Ala Arg Arg Gly Phe  Ile Cys Lys Lys Thr  Thr Ser Asn 
    1910                 1915                 1920             


Lys Leu  Glu Asn Gly Gly Thr  His Arg Glu Lys Lys  Glu Ser Thr 
    1925                 1930                 1935             


Pro Ser  Thr Ala Ser Leu Pro  Ser Tyr Asp Ser Val  Thr Lys Pro 
    1940                 1945                 1950             


Glu Lys  Glu Lys Gln Gln Arg  Ala Glu Glu Gly Arg  Arg Glu Arg 
    1955                 1960                 1965             


Ala Lys  Arg Gln Lys Glu Val  Arg Glu Ser Lys Cys  
    1970                 1975                 1980 


<210> 8
<211> 1977
<212> PRT
<213> Homo sapiens

<400> 8
Met Ala Met Leu Pro Pro Pro Gly Pro Gln Ser Phe Val His Phe Thr 
1               5                   10                  15      


Lys Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ala Glu Arg Lys Ser 
            20                  25                  30          


Lys Glu Pro Lys Glu Glu Lys Lys Asp Asp Asp Glu Glu Ala Pro Lys 
        35                  40                  45              


Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr Gly 
    50                  55                  60                  


Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro 
65                  70                  75                  80  


Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Thr 
                85                  90                  95      


Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr Met Leu Ser Pro Phe 
            100                 105                 110         


Ser Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Leu Phe 
        115                 120                 125             


Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr 
    130                 135                 140                 


Met Asn Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr 
145                 150                 155                 160 


Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile Leu Ala Arg Gly Phe 
                165                 170                 175     


Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 
            180                 185                 190         


Phe Val Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn Leu Gly 
        195                 200                 205             


Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 
    210                 215                 220                 


Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln 
225                 230                 235                 240 


Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu 
                245                 250                 255     


Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Lys 
            260                 265                 270         


His Lys Cys Phe Arg Asn Ser Leu Glu Asn Asn Glu Thr Leu Glu Ser 
        275                 280                 285             


Ile Met Asn Thr Leu Glu Ser Glu Glu Asp Phe Arg Lys Tyr Phe Tyr 
    290                 295                 300                 


Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr Asp 
305                 310                 315                 320 


Ser Gly Gln Cys Pro Glu Gly Tyr Thr Cys Val Lys Ile Gly Arg Asn 
                325                 330                 335     


Pro Asp Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe Leu 
            340                 345                 350         


Ala Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln 
        355                 360                 365             


Gln Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val 
    370                 375                 380                 


Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val 
385                 390                 395                 400 


Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Asn Ile Glu Glu Ala 
                405                 410                 415     


Lys Gln Lys Glu Leu Glu Phe Gln Gln Met Leu Asp Arg Leu Lys Lys 
            420                 425                 430         


Glu Gln Glu Glu Ala Glu Ala Ile Ala Ala Ala Ala Ala Glu Tyr Thr 
        435                 440                 445             


Ser Ile Arg Arg Ser Arg Ile Met Gly Leu Ser Glu Ser Ser Ser Glu 
    450                 455                 460                 


Thr Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg 
465                 470                 475                 480 


Lys Lys Lys Asn Gln Lys Lys Leu Ser Ser Gly Glu Glu Lys Gly Asp 
                485                 490                 495     


Ala Glu Lys Leu Ser Lys Ser Glu Ser Glu Asp Ser Ile Arg Arg Lys 
            500                 505                 510         


Ser Phe His Leu Gly Val Glu Gly His Arg Arg Ala His Glu Lys Arg 
        515                 520                 525             


Leu Ser Thr Pro Asn Gln Ser Pro Leu Ser Ile Arg Gly Ser Leu Phe 
    530                 535                 540                 


Ser Ala Arg Arg Ser Ser Arg Thr Ser Leu Phe Ser Phe Lys Gly Arg 
545                 550                 555                 560 


Gly Arg Asp Ile Gly Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser 
                565                 570                 575     


Ile Phe Gly Asp Asn Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His 
            580                 585                 590         


Arg Pro Gln Glu Arg Arg Ser Ser Asn Ile Ser Gln Ala Ser Arg Ser 
        595                 600                 605             


Pro Pro Met Leu Pro Val Asn Gly Lys Met His Ser Ala Val Asp Cys 
    610                 615                 620                 


Asn Gly Val Val Ser Leu Val Asp Gly Arg Ser Ala Leu Met Leu Pro 
625                 630                 635                 640 


Asn Gly Gln Leu Leu Pro Glu Gly Thr Thr Asn Gln Ile His Lys Lys 
                645                 650                 655     


Arg Arg Cys Ser Ser Tyr Leu Leu Ser Glu Asp Met Leu Asn Asp Pro 
            660                 665                 670         


Asn Leu Arg Gln Arg Ala Met Ser Arg Ala Ser Ile Leu Thr Asn Thr 
        675                 680                 685             


Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro Trp Trp Tyr 
    690                 695                 700                 


Arg Phe Ala His Lys Phe Leu Ile Trp Asn Cys Ser Pro Tyr Trp Ile 
705                 710                 715                 720 


Lys Phe Lys Lys Cys Ile Tyr Phe Ile Val Met Asp Pro Phe Val Asp 
                725                 730                 735     


Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met 
            740                 745                 750         


Glu His His Pro Met Thr Glu Glu Phe Lys Asn Val Leu Ala Ile Gly 
        755                 760                 765             


Asn Leu Val Phe Thr Gly Ile Phe Ala Ala Glu Met Val Leu Lys Leu 
    770                 775                 780                 


Ile Ala Met Asp Pro Tyr Glu Tyr Phe Gln Val Gly Trp Asn Ile Phe 
785                 790                 795                 800 


Asp Ser Leu Ile Val Thr Leu Ser Leu Val Glu Leu Phe Leu Ala Asp 
                805                 810                 815     


Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe 
            820                 825                 830         


Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile 
        835                 840                 845             


Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile 
    850                 855                 860                 


Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser 
865                 870                 875                 880 


Tyr Lys Glu Cys Val Cys Lys Ile Asn Asp Asp Cys Thr Leu Pro Arg 
                885                 890                 895     


Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val Phe Arg Val 
            900                 905                 910         


Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala 
        915                 920                 925             


Gly Gln Ala Met Cys Leu Ile Val Tyr Met Met Val Met Val Ile Gly 
    930                 935                 940                 


Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe 
945                 950                 955                 960 


Ser Ser Asp Asn Leu Thr Ala Ile Glu Glu Asp Pro Asp Ala Asn Asn 
                965                 970                 975     


Leu Gln Ile Ala Val Thr Arg Ile Lys Lys Gly Ile Asn Tyr Val Lys 
            980                 985                 990         


Gln Thr Leu Arg Glu Phe Ile Leu  Lys Ala Phe Ser Lys  Lys Pro Lys 
        995                 1000                 1005             


Ile Ser  Arg Glu Ile Arg Gln  Ala Glu Asp Leu Asn  Thr Lys Lys 
    1010                 1015                 1020             


Glu Asn  Tyr Ile Ser Asn His  Thr Leu Ala Glu Met  Ser Lys Gly 
    1025                 1030                 1035             


His Asn  Phe Leu Lys Glu Lys  Asp Lys Ile Ser Gly  Phe Gly Ser 
    1040                 1045                 1050             


Ser Val  Asp Lys His Leu Met  Glu Asp Ser Asp Gly  Gln Ser Phe 
    1055                 1060                 1065             


Ile His  Asn Pro Ser Leu Thr  Val Thr Val Pro Ile  Ala Pro Gly 
    1070                 1075                 1080             


Glu Ser  Asp Leu Glu Asn Met  Asn Ala Glu Glu Leu  Ser Ser Asp 
    1085                 1090                 1095             


Ser Asp  Ser Glu Tyr Ser Lys  Val Arg Leu Asn Arg  Ser Ser Ser 
    1100                 1105                 1110             


Ser Glu  Cys Ser Thr Val Asp  Asn Pro Leu Pro Gly  Glu Gly Glu 
    1115                 1120                 1125             


Glu Ala  Glu Ala Glu Pro Met  Asn Ser Asp Glu Pro  Glu Ala Cys 
    1130                 1135                 1140             


Phe Thr  Asp Gly Cys Val Arg  Arg Phe Ser Cys Cys  Gln Val Asn 
    1145                 1150                 1155             


Ile Glu  Ser Gly Lys Gly Lys  Ile Trp Trp Asn Ile  Arg Lys Thr 
    1160                 1165                 1170             


Cys Tyr  Lys Ile Val Glu His  Ser Trp Phe Glu Ser  Phe Ile Val 
    1175                 1180                 1185             


Leu Met  Ile Leu Leu Ser Ser  Gly Ala Leu Ala Phe  Glu Asp Ile 
    1190                 1195                 1200             


Tyr Ile  Glu Arg Lys Lys Thr  Ile Lys Ile Ile Leu  Glu Tyr Ala 
    1205                 1210                 1215             


Asp Lys  Ile Phe Thr Tyr Ile  Phe Ile Leu Glu Met  Leu Leu Lys 
    1220                 1225                 1230             


Trp Ile  Ala Tyr Gly Tyr Lys  Thr Tyr Phe Thr Asn  Ala Trp Cys 
    1235                 1240                 1245             


Trp Leu  Asp Phe Leu Ile Val  Asp Val Ser Leu Val  Thr Leu Val 
    1250                 1255                 1260             


Ala Asn  Thr Leu Gly Tyr Ser  Asp Leu Gly Pro Ile  Lys Ser Leu 
    1265                 1270                 1275             


Arg Thr  Leu Arg Ala Leu Arg  Pro Leu Arg Ala Leu  Ser Arg Phe 
    1280                 1285                 1290             


Glu Gly  Met Arg Val Val Val  Asn Ala Leu Ile Gly  Ala Ile Pro 
    1295                 1300                 1305             


Ser Ile  Met Asn Val Leu Leu  Val Cys Leu Ile Phe  Trp Leu Ile 
    1310                 1315                 1320             


Phe Ser  Ile Met Gly Val Asn  Leu Phe Ala Gly Lys  Phe Tyr Glu 
    1325                 1330                 1335             


Cys Ile  Asn Thr Thr Asp Gly  Ser Arg Phe Pro Ala  Ser Gln Val 
    1340                 1345                 1350             


Pro Asn  Arg Ser Glu Cys Phe  Ala Leu Met Asn Val  Ser Gln Asn 
    1355                 1360                 1365             


Val Arg  Trp Lys Asn Leu Lys  Val Asn Phe Asp Asn  Val Gly Leu 
    1370                 1375                 1380             


Gly Tyr  Leu Ser Leu Leu Gln  Val Ala Thr Phe Lys  Gly Trp Thr 
    1385                 1390                 1395             


Ile Ile  Met Tyr Ala Ala Val  Asp Ser Val Asn Val  Asp Lys Gln 
    1400                 1405                 1410             


Pro Lys  Tyr Glu Tyr Ser Leu  Tyr Met Tyr Ile Tyr  Phe Val Val 
    1415                 1420                 1425             


Phe Ile  Ile Phe Gly Ser Phe  Phe Thr Leu Asn Leu  Phe Ile Gly 
    1430                 1435                 1440             


Val Ile  Ile Asp Asn Phe Asn  Gln Gln Lys Lys Lys  Leu Gly Gly 
    1445                 1450                 1455             


Gln Asp  Ile Phe Met Thr Glu  Glu Gln Lys Lys Tyr  Tyr Asn Ala 
    1460                 1465                 1470             


Met Lys  Lys Leu Gly Ser Lys  Lys Pro Gln Lys Pro  Ile Pro Arg 
    1475                 1480                 1485             


Pro Gly  Asn Lys Ile Gln Gly  Cys Ile Phe Asp Leu  Val Thr Asn 
    1490                 1495                 1500             


Gln Ala  Phe Asp Ile Ser Ile  Met Val Leu Ile Cys  Leu Asn Met 
    1505                 1510                 1515             


Val Thr  Met Met Val Glu Lys  Glu Gly Gln Ser Gln  His Met Thr 
    1520                 1525                 1530             


Glu Val  Leu Tyr Trp Ile Asn  Val Val Phe Ile Ile  Leu Phe Thr 
    1535                 1540                 1545             


Gly Glu  Cys Val Leu Lys Leu  Ile Ser Leu Arg His  Tyr Tyr Phe 
    1550                 1555                 1560             


Thr Val  Gly Trp Asn Ile Phe  Asp Phe Val Val Val  Ile Ile Ser 
    1565                 1570                 1575             


Ile Val  Gly Met Phe Leu Ala  Asp Leu Ile Glu Thr  Tyr Phe Val 
    1580                 1585                 1590             


Ser Pro  Thr Leu Phe Arg Val  Ile Arg Leu Ala Arg  Ile Gly Arg 
    1595                 1600                 1605             


Ile Leu  Arg Leu Val Lys Gly  Ala Lys Gly Ile Arg  Thr Leu Leu 
    1610                 1615                 1620             


Phe Ala  Leu Met Met Ser Leu  Pro Ala Leu Phe Asn  Ile Gly Leu 
    1625                 1630                 1635             


Leu Leu  Phe Leu Val Met Phe  Ile Tyr Ala Ile Phe  Gly Met Ser 
    1640                 1645                 1650             


Asn Phe  Ala Tyr Val Lys Lys  Glu Asp Gly Ile Asn  Asp Met Phe 
    1655                 1660                 1665             


Asn Phe  Glu Thr Phe Gly Asn  Ser Met Ile Cys Leu  Phe Gln Ile 
    1670                 1675                 1680             


Thr Thr  Ser Ala Gly Trp Asp  Gly Leu Leu Ala Pro  Ile Leu Asn 
    1685                 1690                 1695             


Ser Lys  Pro Pro Asp Cys Asp  Pro Lys Lys Val His  Pro Gly Ser 
    1700                 1705                 1710             


Ser Val  Glu Gly Asp Cys Gly  Asn Pro Ser Val Gly  Ile Phe Tyr 
    1715                 1720                 1725             


Phe Val  Ser Tyr Ile Ile Ile  Ser Phe Leu Val Val  Val Asn Met 
    1730                 1735                 1740             


Tyr Ile  Ala Val Ile Leu Glu  Asn Phe Ser Val Ala  Thr Glu Glu 
    1745                 1750                 1755             


Ser Thr  Glu Pro Leu Ser Glu  Asp Asp Phe Glu Met  Phe Tyr Glu 
    1760                 1765                 1770             


Val Trp  Glu Lys Phe Asp Pro  Asp Ala Thr Gln Phe  Ile Glu Phe 
    1775                 1780                 1785             


Ser Lys  Leu Ser Asp Phe Ala  Ala Ala Leu Asp Pro  Pro Leu Leu 
    1790                 1795                 1800             


Ile Ala  Lys Pro Asn Lys Val  Gln Leu Ile Ala Met  Asp Leu Pro 
    1805                 1810                 1815             


Met Val  Ser Gly Asp Arg Ile  His Cys Leu Asp Ile  Leu Phe Ala 
    1820                 1825                 1830             


Phe Thr  Lys Arg Val Leu Gly  Glu Ser Gly Glu Met  Asp Ser Leu 
    1835                 1840                 1845             


Arg Ser  Gln Met Glu Glu Arg  Phe Met Ser Ala Asn  Pro Ser Lys 
    1850                 1855                 1860             


Val Ser  Tyr Glu Pro Ile Thr  Thr Thr Leu Lys Arg  Lys Gln Glu 
    1865                 1870                 1875             


Asp Val  Ser Ala Thr Val Ile  Gln Arg Ala Tyr Arg  Arg Tyr Arg 
    1880                 1885                 1890             


Leu Arg  Gln Asn Val Lys Asn  Ile Ser Ser Ile Tyr  Ile Lys Asp 
    1895                 1900                 1905             


Gly Asp  Arg Asp Asp Asp Leu  Leu Asn Lys Lys Asp  Met Ala Phe 
    1910                 1915                 1920             


Asp Asn  Val Asn Glu Asn Ser  Ser Pro Glu Lys Thr  Asp Ala Thr 
    1925                 1930                 1935             


Ser Ser  Thr Thr Ser Pro Pro  Ser Tyr Asp Ser Val  Thr Lys Pro 
    1940                 1945                 1950             


Asp Lys  Glu Lys Tyr Glu Gln  Asp Arg Thr Glu Lys  Glu Asp Lys 
    1955                 1960                 1965             


Gly Lys  Asp Ser Lys Glu Ser  Lys Lys 
    1970                 1975         


<210> 9
<211> 1956
<212> PRT
<213> Homo sapiens

<400> 9
Met Glu Phe Pro Ile Gly Ser Leu Glu Thr Asn Asn Phe Arg Arg Phe 
1               5                   10                  15      


Thr Pro Glu Ser Leu Val Glu Ile Glu Lys Gln Ile Ala Ala Lys Gln 
            20                  25                  30          


Gly Thr Lys Lys Ala Arg Glu Lys His Arg Glu Gln Lys Asp Gln Glu 
        35                  40                  45              


Glu Lys Pro Arg Pro Gln Leu Asp Leu Lys Ala Cys Asn Gln Leu Pro 
    50                  55                  60                  


Lys Phe Tyr Gly Glu Leu Pro Ala Glu Leu Ile Gly Glu Pro Leu Glu 
65                  70                  75                  80  


Asp Leu Asp Pro Phe Tyr Ser Thr His Arg Thr Phe Met Val Leu Asn 
                85                  90                  95      


Lys Gly Arg Thr Ile Ser Arg Phe Ser Ala Thr Arg Ala Leu Trp Leu 
            100                 105                 110         


Phe Ser Pro Phe Asn Leu Ile Arg Arg Thr Ala Ile Lys Val Ser Val 
        115                 120                 125             


His Ser Trp Phe Ser Leu Phe Ile Thr Val Thr Ile Leu Val Asn Cys 
    130                 135                 140                 


Val Cys Met Thr Arg Thr Asp Leu Pro Glu Lys Ile Glu Tyr Val Phe 
145                 150                 155                 160 


Thr Val Ile Tyr Thr Phe Glu Ala Leu Ile Lys Ile Leu Ala Arg Gly 
                165                 170                 175     


Phe Cys Leu Asn Glu Phe Thr Tyr Leu Arg Asp Pro Trp Asn Trp Leu 
            180                 185                 190         


Asp Phe Ser Val Ile Thr Leu Ala Tyr Val Gly Thr Ala Ile Asp Leu 
        195                 200                 205             


Arg Gly Ile Ser Gly Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys 
    210                 215                 220                 


Thr Val Ser Val Ile Pro Gly Leu Lys Val Ile Val Gly Ala Leu Ile 
225                 230                 235                 240 


His Ser Val Lys Lys Leu Ala Asp Val Thr Ile Leu Thr Ile Phe Cys 
                245                 250                 255     


Leu Ser Val Phe Ala Leu Val Gly Leu Gln Leu Phe Lys Gly Asn Leu 
            260                 265                 270         


Lys Asn Lys Cys Val Lys Asn Asp Met Ala Val Asn Glu Thr Thr Asn 
        275                 280                 285             


Tyr Ser Ser His Arg Lys Pro Asp Ile Tyr Ile Asn Lys Arg Gly Thr 
    290                 295                 300                 


Ser Asp Pro Leu Leu Cys Gly Asn Gly Ser Asp Ser Gly His Cys Pro 
305                 310                 315                 320 


Asp Gly Tyr Ile Cys Leu Lys Thr Ser Asp Asn Pro Asp Phe Asn Tyr 
                325                 330                 335     


Thr Ser Phe Asp Ser Phe Ala Trp Ala Phe Leu Ser Leu Phe Arg Leu 
            340                 345                 350         


Met Thr Gln Asp Ser Trp Glu Arg Leu Tyr Gln Gln Thr Leu Arg Thr 
        355                 360                 365             


Ser Gly Lys Ile Tyr Met Ile Phe Phe Val Leu Val Ile Phe Leu Gly 
    370                 375                 380                 


Ser Phe Tyr Leu Val Asn Leu Ile Leu Ala Val Val Thr Met Ala Tyr 
385                 390                 395                 400 


Glu Glu Gln Asn Gln Ala Thr Thr Asp Glu Ile Glu Ala Lys Glu Lys 
                405                 410                 415     


Lys Phe Gln Glu Ala Leu Glu Met Leu Arg Lys Glu Gln Glu Val Leu 
            420                 425                 430         


Ala Ala Leu Gly Ile Asp Thr Thr Ser Leu His Ser His Asn Gly Ser 
        435                 440                 445             


Pro Leu Thr Ser Lys Asn Ala Ser Glu Arg Arg His Arg Ile Lys Pro 
    450                 455                 460                 


Arg Val Ser Glu Gly Ser Thr Glu Asp Asn Lys Ser Pro Arg Ser Asp 
465                 470                 475                 480 


Pro Tyr Asn Gln Arg Arg Met Ser Phe Leu Gly Leu Ala Ser Gly Lys 
                485                 490                 495     


Arg Arg Ala Ser His Gly Ser Val Phe His Phe Arg Ser Pro Gly Arg 
            500                 505                 510         


Asp Ile Ser Leu Pro Glu Gly Val Thr Asp Asp Gly Val Phe Pro Gly 
        515                 520                 525             


Asp His Glu Ser His Arg Gly Ser Leu Leu Leu Gly Gly Gly Ala Gly 
    530                 535                 540                 


Gln Gln Gly Pro Leu Pro Arg Ser Pro Leu Pro Gln Pro Ser Asn Pro 
545                 550                 555                 560 


Asp Ser Arg His Gly Glu Asp Glu His Gln Pro Pro Pro Thr Ser Glu 
                565                 570                 575     


Leu Ala Pro Gly Ala Val Asp Val Ser Ala Phe Asp Ala Gly Gln Lys 
            580                 585                 590         


Lys Thr Phe Leu Ser Ala Glu Tyr Leu Asp Glu Pro Phe Arg Ala Gln 
        595                 600                 605             


Arg Ala Met Ser Val Val Ser Ile Ile Thr Ser Val Leu Glu Glu Leu 
    610                 615                 620                 


Glu Glu Ser Glu Gln Lys Cys Pro Pro Cys Leu Thr Ser Leu Ser Gln 
625                 630                 635                 640 


Lys Tyr Leu Ile Trp Asp Cys Cys Pro Met Trp Val Lys Leu Lys Thr 
                645                 650                 655     


Ile Leu Phe Gly Leu Val Thr Asp Pro Phe Ala Glu Leu Thr Ile Thr 
            660                 665                 670         


Leu Cys Ile Val Val Asn Thr Ile Phe Met Ala Met Glu His His Gly 
        675                 680                 685             


Met Ser Pro Thr Phe Glu Ala Met Leu Gln Ile Gly Asn Ile Val Phe 
    690                 695                 700                 


Thr Ile Phe Phe Thr Ala Glu Met Val Phe Lys Ile Ile Ala Phe Asp 
705                 710                 715                 720 


Pro Tyr Tyr Tyr Phe Gln Lys Lys Trp Asn Ile Phe Asp Cys Ile Ile 
                725                 730                 735     


Val Thr Val Ser Leu Leu Glu Leu Gly Val Ala Lys Lys Gly Ser Leu 
            740                 745                 750         


Ser Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys 
        755                 760                 765             


Ser Trp Pro Thr Leu Asn Thr Leu Ile Lys Ile Ile Gly Asn Ser Val 
    770                 775                 780                 


Gly Ala Leu Gly Asn Leu Thr Ile Ile Leu Ala Ile Ile Val Phe Val 
785                 790                 795                 800 


Phe Ala Leu Val Gly Lys Gln Leu Leu Gly Glu Asn Tyr Arg Asn Asn 
                805                 810                 815     


Arg Lys Asn Ile Ser Ala Pro His Glu Asp Trp Pro Arg Trp His Met 
            820                 825                 830         


His Asp Phe Phe His Ser Phe Leu Ile Val Phe Arg Ile Leu Cys Gly 
        835                 840                 845             


Glu Trp Ile Glu Asn Met Trp Ala Cys Met Glu Val Gly Gln Lys Ser 
    850                 855                 860                 


Ile Cys Leu Ile Leu Phe Leu Thr Val Met Val Leu Gly Asn Leu Val 
865                 870                 875                 880 


Val Leu Asn Leu Phe Ile Ala Leu Leu Leu Asn Ser Phe Ser Ala Asp 
                885                 890                 895     


Asn Leu Thr Ala Pro Glu Asp Asp Gly Glu Val Asn Asn Leu Gln Val 
            900                 905                 910         


Ala Leu Ala Arg Ile Gln Val Phe Gly His Arg Thr Lys Gln Ala Leu 
        915                 920                 925             


Cys Ser Phe Phe Ser Arg Ser Cys Pro Phe Pro Gln Pro Lys Ala Glu 
    930                 935                 940                 


Pro Glu Leu Val Val Lys Leu Pro Leu Ser Ser Ser Lys Ala Glu Asn 
945                 950                 955                 960 


His Ile Ala Ala Asn Thr Ala Arg Gly Ser Ser Gly Gly Leu Gln Ala 
                965                 970                 975     


Pro Arg Gly Pro Arg Asp Glu His Ser Asp Phe Ile Ala Asn Pro Thr 
            980                 985                 990         


Val Trp Val Ser Val Pro Ile Ala  Glu Gly Glu Ser Asp  Leu Asp Asp 
        995                 1000                 1005             


Leu Glu  Asp Asp Gly Gly Glu  Asp Ala Gln Ser Phe  Gln Gln Glu 
    1010                 1015                 1020             


Val Ile  Pro Lys Gly Gln Gln  Glu Gln Leu Gln Gln  Val Glu Arg 
    1025                 1030                 1035             


Cys Gly  Asp His Leu Thr Pro  Arg Ser Pro Gly Thr  Gly Thr Ser 
    1040                 1045                 1050             


Ser Glu  Asp Leu Ala Pro Ser  Leu Gly Glu Thr Trp  Lys Asp Glu 
    1055                 1060                 1065             


Ser Val  Pro Gln Val Pro Ala  Glu Gly Val Asp Asp  Thr Ser Ser 
    1070                 1075                 1080             


Ser Glu  Gly Ser Thr Val Asp  Cys Leu Asp Pro Glu  Glu Ile Leu 
    1085                 1090                 1095             


Arg Lys  Ile Pro Glu Leu Ala  Asp Asp Leu Glu Glu  Pro Asp Asp 
    1100                 1105                 1110             


Cys Phe  Thr Glu Gly Cys Ile  Arg His Cys Pro Cys  Cys Lys Leu 
    1115                 1120                 1125             


Asp Thr  Thr Lys Ser Pro Trp  Asp Val Gly Trp Gln  Val Arg Lys 
    1130                 1135                 1140             


Thr Cys  Tyr Arg Ile Val Glu  His Ser Trp Phe Glu  Ser Phe Ile 
    1145                 1150                 1155             


Ile Phe  Met Ile Leu Leu Ser  Ser Gly Ser Leu Ala  Phe Glu Asp 
    1160                 1165                 1170             


Tyr Tyr  Leu Asp Gln Lys Pro  Thr Val Lys Ala Leu  Leu Glu Tyr 
    1175                 1180                 1185             


Thr Asp  Arg Val Phe Thr Phe  Ile Phe Val Phe Glu  Met Leu Leu 
    1190                 1195                 1200             


Lys Trp  Val Ala Tyr Gly Phe  Lys Lys Tyr Phe Thr  Asn Ala Trp 
    1205                 1210                 1215             


Cys Trp  Leu Asp Phe Leu Ile  Val Asn Ile Ser Leu  Ile Ser Leu 
    1220                 1225                 1230             


Thr Ala  Lys Ile Leu Glu Tyr  Ser Glu Val Ala Pro  Ile Lys Ala 
    1235                 1240                 1245             


Leu Arg  Thr Leu Arg Ala Leu  Arg Pro Leu Arg Ala  Leu Ser Arg 
    1250                 1255                 1260             


Phe Glu  Gly Met Arg Val Val  Val Asp Ala Leu Val  Gly Ala Ile 
    1265                 1270                 1275             


Pro Ser  Ile Met Asn Val Leu  Leu Val Cys Leu Ile  Phe Trp Leu 
    1280                 1285                 1290             


Ile Phe  Ser Ile Met Gly Val  Asn Leu Phe Ala Gly  Lys Phe Trp 
    1295                 1300                 1305             


Arg Cys  Ile Asn Tyr Thr Asp  Gly Glu Phe Ser Leu  Val Pro Leu 
    1310                 1315                 1320             


Ser Ile  Val Asn Asn Lys Ser  Asp Cys Lys Ile Gln  Asn Ser Thr 
    1325                 1330                 1335             


Gly Ser  Phe Phe Trp Val Asn  Val Lys Val Asn Phe  Asp Asn Val 
    1340                 1345                 1350             


Ala Met  Gly Tyr Leu Ala Leu  Leu Gln Val Ala Thr  Phe Lys Gly 
    1355                 1360                 1365             


Trp Met  Asp Ile Met Tyr Ala  Ala Val Asp Ser Arg  Glu Val Asn 
    1370                 1375                 1380             


Met Gln  Pro Lys Trp Glu Asp  Asn Val Tyr Met Tyr  Leu Tyr Phe 
    1385                 1390                 1395             


Val Ile  Phe Ile Ile Phe Gly  Gly Phe Phe Thr Leu  Asn Leu Phe 
    1400                 1405                 1410             


Val Gly  Val Ile Ile Asp Asn  Phe Asn Gln Gln Lys  Lys Lys Leu 
    1415                 1420                 1425             


Gly Gly  Gln Asp Ile Phe Met  Thr Glu Glu Gln Lys  Lys Tyr Tyr 
    1430                 1435                 1440             


Asn Ala  Met Lys Lys Leu Gly  Ser Lys Lys Pro Gln  Lys Pro Ile 
    1445                 1450                 1455             


Pro Arg  Pro Leu Asn Lys Phe  Gln Gly Phe Val Phe  Asp Ile Val 
    1460                 1465                 1470             


Thr Arg  Gln Ala Phe Asp Ile  Thr Ile Met Val Leu  Ile Cys Leu 
    1475                 1480                 1485             


Asn Met  Ile Thr Met Met Val  Glu Thr Asp Asp Gln  Ser Glu Glu 
    1490                 1495                 1500             


Lys Thr  Lys Ile Leu Gly Lys  Ile Asn Gln Phe Phe  Val Ala Val 
    1505                 1510                 1515             


Phe Thr  Gly Glu Cys Val Met  Lys Met Phe Ala Leu  Arg Gln Tyr 
    1520                 1525                 1530             


Tyr Phe  Thr Asn Gly Trp Asn  Val Phe Asp Phe Ile  Val Val Val 
    1535                 1540                 1545             


Leu Ser  Ile Ala Ser Leu Ile  Phe Ser Ala Ile Leu  Lys Ser Leu 
    1550                 1555                 1560             


Gln Ser  Tyr Phe Ser Pro Thr  Leu Phe Arg Val Ile  Arg Leu Ala 
    1565                 1570                 1575             


Arg Ile  Gly Arg Ile Leu Arg  Leu Ile Arg Ala Ala  Lys Gly Ile 
    1580                 1585                 1590             


Arg Thr  Leu Leu Phe Ala Leu  Met Met Ser Leu Pro  Ala Leu Phe 
    1595                 1600                 1605             


Asn Ile  Gly Leu Leu Leu Phe  Leu Val Met Phe Ile  Tyr Ser Ile 
    1610                 1615                 1620             


Phe Gly  Met Ser Ser Phe Pro  His Val Arg Trp Glu  Ala Gly Ile 
    1625                 1630                 1635             


Asp Asp  Met Phe Asn Phe Gln  Thr Phe Ala Asn Ser  Met Leu Cys 
    1640                 1645                 1650             


Leu Phe  Gln Ile Thr Thr Ser  Ala Gly Trp Asp Gly  Leu Leu Ser 
    1655                 1660                 1665             


Pro Ile  Leu Asn Thr Gly Pro  Pro Tyr Cys Asp Pro  Asn Leu Pro 
    1670                 1675                 1680             


Asn Ser  Asn Gly Thr Arg Gly  Asp Cys Gly Ser Pro  Ala Val Gly 
    1685                 1690                 1695             


Ile Ile  Phe Phe Thr Thr Tyr  Ile Ile Ile Ser Phe  Leu Ile Met 
    1700                 1705                 1710             


Val Asn  Met Tyr Ile Ala Val  Ile Leu Glu Asn Phe  Asn Val Ala 
    1715                 1720                 1725             


Thr Glu  Glu Ser Thr Glu Pro  Leu Ser Glu Asp Asp  Phe Asp Met 
    1730                 1735                 1740             


Phe Tyr  Glu Thr Trp Glu Lys  Phe Asp Pro Glu Ala  Thr Gln Phe 
    1745                 1750                 1755             


Ile Thr  Phe Ser Ala Leu Ser  Asp Phe Ala Asp Thr  Leu Ser Gly 
    1760                 1765                 1770             


Pro Leu  Arg Ile Pro Lys Pro  Asn Arg Asn Ile Leu  Ile Gln Met 
    1775                 1780                 1785             


Asp Leu  Pro Leu Val Pro Gly  Asp Lys Ile His Cys  Leu Asp Ile 
    1790                 1795                 1800             


Leu Phe  Ala Phe Thr Lys Asn  Val Leu Gly Glu Ser  Gly Glu Leu 
    1805                 1810                 1815             


Asp Ser  Leu Lys Ala Asn Met  Glu Glu Lys Phe Met  Ala Thr Asn 
    1820                 1825                 1830             


Leu Ser  Lys Ser Ser Tyr Glu  Pro Ile Ala Thr Thr  Leu Arg Trp 
    1835                 1840                 1845             


Lys Gln  Glu Asp Ile Ser Ala  Thr Val Ile Gln Lys  Ala Tyr Arg 
    1850                 1855                 1860             


Ser Tyr  Val Leu His Arg Ser  Met Ala Leu Ser Asn  Thr Pro Cys 
    1865                 1870                 1875             


Val Pro  Arg Ala Glu Glu Glu  Ala Ala Ser Leu Pro  Asp Glu Gly 
    1880                 1885                 1890             


Phe Val  Ala Phe Thr Ala Asn  Glu Asn Cys Val Leu  Pro Asp Lys 
    1895                 1900                 1905             


Ser Glu  Thr Ala Ser Ala Thr  Ser Phe Pro Pro Ser  Tyr Glu Ser 
    1910                 1915                 1920             


Val Thr  Arg Gly Leu Ser Asp  Arg Val Asn Met Arg  Thr Ser Ser 
    1925                 1930                 1935             


Ser Ile  Gln Asn Glu Asp Glu  Ala Thr Ser Met Glu  Leu Ile Ala 
    1940                 1945                 1950             


Pro Gly  Pro 
    1955     


<210> 10
<211> 1791
<212> PRT
<213> Homo sapiens

<400> 10
Met Asp Asp Arg Cys Tyr Pro Val Ile Phe Pro Asp Glu Arg Asn Phe 
1               5                   10                  15      


Arg Pro Phe Thr Ser Asp Ser Leu Ala Ala Ile Glu Lys Arg Ile Ala 
            20                  25                  30          


Ile Gln Lys Glu Lys Lys Lys Ser Lys Asp Gln Thr Gly Glu Val Pro 
        35                  40                  45              


Gln Pro Arg Pro Gln Leu Asp Leu Lys Ala Ser Arg Lys Leu Pro Lys 
    50                  55                  60                  


Leu Tyr Gly Asp Ile Pro Arg Glu Leu Ile Gly Lys Pro Leu Glu Asp 
65                  70                  75                  80  


Leu Asp Pro Phe Tyr Arg Asn His Lys Thr Phe Met Val Leu Asn Arg 
                85                  90                  95      


Lys Arg Thr Ile Tyr Arg Phe Ser Ala Lys His Ala Leu Phe Ile Phe 
            100                 105                 110         


Gly Pro Phe Asn Ser Ile Arg Ser Leu Ala Ile Arg Val Ser Val His 
        115                 120                 125             


Ser Leu Phe Ser Met Phe Ile Ile Gly Thr Val Ile Ile Asn Cys Val 
    130                 135                 140                 


Phe Met Ala Thr Gly Pro Ala Lys Asn Ser Asn Ser Asn Asn Thr Asp 
145                 150                 155                 160 


Ile Ala Glu Cys Val Phe Thr Gly Ile Tyr Ile Phe Glu Ala Leu Ile 
                165                 170                 175     


Lys Ile Leu Ala Arg Gly Phe Ile Leu Asp Glu Phe Ser Phe Leu Arg 
            180                 185                 190         


Asp Pro Trp Asn Trp Leu Asp Ser Ile Val Ile Gly Ile Ala Ile Val 
        195                 200                 205             


Ser Tyr Ile Pro Gly Ile Thr Ile Lys Leu Leu Pro Leu Arg Thr Phe 
    210                 215                 220                 


Arg Val Phe Arg Ala Leu Lys Ala Ile Ser Val Val Ser Arg Leu Lys 
225                 230                 235                 240 


Val Ile Val Gly Ala Leu Leu Arg Ser Val Lys Lys Leu Val Asn Val 
                245                 250                 255     


Ile Ile Leu Thr Phe Phe Cys Leu Ser Ile Phe Ala Leu Val Gly Gln 
            260                 265                 270         


Gln Leu Phe Met Gly Ser Leu Asn Leu Lys Cys Ile Ser Arg Asp Cys 
        275                 280                 285             


Lys Asn Ile Ser Asn Pro Glu Ala Tyr Asp His Cys Phe Glu Lys Lys 
    290                 295                 300                 


Glu Asn Ser Pro Glu Phe Lys Met Cys Gly Ile Trp Met Gly Asn Ser 
305                 310                 315                 320 


Ala Cys Ser Ile Gln Tyr Glu Cys Lys His Thr Lys Ile Asn Pro Asp 
                325                 330                 335     


Tyr Asn Tyr Thr Asn Phe Asp Asn Phe Gly Trp Ser Phe Leu Ala Met 
            340                 345                 350         


Phe Arg Leu Met Thr Gln Asp Ser Trp Glu Lys Leu Tyr Gln Gln Thr 
        355                 360                 365             


Leu Arg Thr Thr Gly Leu Tyr Ser Val Phe Phe Phe Ile Val Val Ile 
    370                 375                 380                 


Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Thr Leu Ala Val Val Thr 
385                 390                 395                 400 


Met Ala Tyr Glu Glu Gln Asn Lys Asn Val Ala Ala Glu Ile Glu Ala 
                405                 410                 415     


Lys Glu Lys Met Phe Gln Glu Ala Gln Gln Leu Leu Lys Glu Glu Lys 
            420                 425                 430         


Glu Ala Leu Val Ala Met Gly Ile Asp Arg Ser Ser Leu Thr Ser Leu 
        435                 440                 445             


Glu Thr Ser Tyr Phe Thr Pro Lys Lys Arg Lys Leu Phe Gly Asn Lys 
    450                 455                 460                 


Lys Arg Lys Ser Phe Phe Leu Arg Glu Ser Gly Lys Asp Gln Pro Pro 
465                 470                 475                 480 


Gly Ser Asp Ser Asp Glu Asp Cys Gln Lys Lys Pro Gln Leu Leu Glu 
                485                 490                 495     


Gln Thr Lys Arg Leu Ser Gln Asn Leu Ser Leu Asp His Phe Asp Glu 
            500                 505                 510         


His Gly Asp Pro Leu Gln Arg Gln Arg Ala Leu Ser Ala Val Ser Ile 
        515                 520                 525             


Leu Thr Ile Thr Met Lys Glu Gln Glu Lys Ser Gln Glu Pro Cys Leu 
    530                 535                 540                 


Pro Cys Gly Glu Asn Leu Ala Ser Lys Tyr Leu Val Trp Asn Cys Cys 
545                 550                 555                 560 


Pro Gln Trp Leu Cys Val Lys Lys Val Leu Arg Thr Val Met Thr Asp 
                565                 570                 575     


Pro Phe Thr Glu Leu Ala Ile Thr Ile Cys Ile Ile Ile Asn Thr Val 
            580                 585                 590         


Phe Leu Ala Met Glu His His Lys Met Glu Ala Ser Phe Glu Lys Met 
        595                 600                 605             


Leu Asn Ile Gly Asn Leu Val Phe Thr Ser Ile Phe Ile Ala Glu Met 
    610                 615                 620                 


Cys Leu Lys Ile Ile Ala Leu Asp Pro Tyr His Tyr Phe Arg Arg Gly 
625                 630                 635                 640 


Trp Asn Ile Phe Asp Ser Ile Val Ala Leu Leu Ser Phe Ala Asp Val 
                645                 650                 655     


Met Asn Cys Val Leu Gln Lys Arg Ser Trp Pro Phe Leu Arg Ser Phe 
            660                 665                 670         


Arg Val Leu Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn 
        675                 680                 685             


Thr Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Ser Leu 
    690                 695                 700                 


Thr Val Val Leu Val Ile Val Ile Phe Ile Phe Ser Val Val Gly Met 
705                 710                 715                 720 


Gln Leu Phe Gly Arg Ser Phe Asn Ser Gln Lys Ser Pro Lys Leu Cys 
                725                 730                 735     


Asn Pro Thr Gly Pro Thr Val Ser Cys Leu Arg His Trp His Met Gly 
            740                 745                 750         


Asp Phe Trp His Ser Phe Leu Val Val Phe Arg Ile Leu Cys Gly Glu 
        755                 760                 765             


Trp Ile Glu Asn Met Trp Glu Cys Met Gln Glu Ala Asn Ala Ser Ser 
    770                 775                 780                 


Ser Leu Cys Val Ile Val Phe Ile Leu Ile Thr Val Ile Gly Lys Leu 
785                 790                 795                 800 


Val Val Leu Asn Leu Phe Ile Ala Leu Leu Leu Asn Ser Phe Ser Asn 
                805                 810                 815     


Glu Glu Arg Asn Gly Asn Leu Glu Gly Glu Ala Arg Lys Thr Lys Val 
            820                 825                 830         


Gln Leu Ala Leu Asp Arg Phe Arg Arg Ala Phe Cys Phe Val Arg His 
        835                 840                 845             


Thr Leu Glu His Phe Cys His Lys Trp Cys Arg Lys Gln Asn Leu Pro 
    850                 855                 860                 


Gln Gln Lys Glu Val Ala Gly Gly Cys Ala Ala Gln Ser Lys Asp Ile 
865                 870                 875                 880 


Ile Pro Leu Val Met Glu Met Lys Arg Gly Ser Glu Thr Gln Glu Glu 
                885                 890                 895     


Leu Gly Ile Leu Thr Ser Val Pro Lys Thr Leu Gly Val Arg His Asp 
            900                 905                 910         


Trp Thr Trp Leu Ala Pro Leu Ala Glu Glu Glu Asp Asp Val Glu Phe 
        915                 920                 925             


Ser Gly Glu Asp Asn Ala Gln Arg Ile Thr Gln Pro Glu Pro Glu Gln 
    930                 935                 940                 


Gln Ala Tyr Glu Leu His Gln Glu Asn Lys Lys Pro Thr Ser Gln Arg 
945                 950                 955                 960 


Val Gln Ser Val Glu Ile Asp Met Phe Ser Glu Asp Glu Pro His Leu 
                965                 970                 975     


Thr Ile Gln Asp Pro Arg Lys Lys Ser Asp Val Thr Ser Ile Leu Ser 
            980                 985                 990         


Glu Cys Ser Thr Ile Asp Leu Gln  Asp Gly Phe Gly Trp  Leu Pro Glu 
        995                 1000                 1005             


Met Val  Pro Lys Lys Gln Pro  Glu Arg Cys Leu Pro  Lys Gly Phe 
    1010                 1015                 1020             


Gly Cys  Cys Phe Pro Cys Cys  Ser Val Asp Lys Arg  Lys Pro Pro 
    1025                 1030                 1035             


Trp Val  Ile Trp Trp Asn Leu  Arg Lys Thr Cys Tyr  Gln Ile Val 
    1040                 1045                 1050             


Lys His  Ser Trp Phe Glu Ser  Phe Ile Ile Phe Val  Ile Leu Leu 
    1055                 1060                 1065             


Ser Ser  Gly Ala Leu Ile Phe  Glu Asp Val His Leu  Glu Asn Gln 
    1070                 1075                 1080             


Pro Lys  Ile Gln Glu Leu Leu  Asn Cys Thr Asp Ile  Ile Phe Thr 
    1085                 1090                 1095             


His Ile  Phe Ile Leu Glu Met  Val Leu Lys Trp Val  Ala Phe Gly 
    1100                 1105                 1110             


Phe Gly  Lys Tyr Phe Thr Ser  Ala Trp Cys Cys Leu  Asp Phe Ile 
    1115                 1120                 1125             


Ile Val  Ile Val Ser Val Thr  Thr Leu Ile Asn Leu  Met Glu Leu 
    1130                 1135                 1140             


Lys Ser  Phe Arg Thr Leu Arg  Ala Leu Arg Pro Leu  Arg Ala Leu 
    1145                 1150                 1155             


Ser Gln  Phe Glu Gly Met Lys  Val Val Val Asn Ala  Leu Ile Gly 
    1160                 1165                 1170             


Ala Ile  Pro Ala Ile Leu Asn  Val Leu Leu Val Cys  Leu Ile Phe 
    1175                 1180                 1185             


Trp Leu  Val Phe Cys Ile Leu  Gly Val Tyr Phe Phe  Ser Gly Lys 
    1190                 1195                 1200             


Phe Gly  Lys Cys Ile Asn Gly  Thr Asp Ser Val Ile  Asn Tyr Thr 
    1205                 1210                 1215             


Ile Ile  Thr Asn Lys Ser Gln  Cys Glu Ser Gly Asn  Phe Ser Trp 
    1220                 1225                 1230             


Ile Asn  Gln Lys Val Asn Phe  Asp Asn Val Gly Asn  Ala Tyr Leu 
    1235                 1240                 1245             


Ala Leu  Leu Gln Val Ala Thr  Phe Lys Gly Trp Met  Asp Ile Ile 
    1250                 1255                 1260             


Tyr Ala  Ala Val Asp Ser Thr  Glu Lys Glu Gln Gln  Pro Glu Phe 
    1265                 1270                 1275             


Glu Ser  Asn Ser Leu Gly Tyr  Ile Tyr Phe Val Val  Phe Ile Ile 
    1280                 1285                 1290             


Phe Gly  Ser Phe Phe Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile 
    1295                 1300                 1305             


Asp Asn  Phe Asn Gln Gln Gln  Lys Lys Leu Gly Gly  Gln Asp Ile 
    1310                 1315                 1320             


Phe Met  Thr Glu Glu Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys 
    1325                 1330                 1335             


Leu Gly  Ser Lys Lys Pro Gln  Lys Pro Ile Pro Arg  Pro Leu Asn 
    1340                 1345                 1350             


Lys Cys  Gln Gly Leu Val Phe  Asp Ile Val Thr Ser  Gln Ile Phe 
    1355                 1360                 1365             


Asp Ile  Ile Ile Ile Ser Leu  Ile Ile Leu Asn Met  Ile Ser Met 
    1370                 1375                 1380             


Met Ala  Glu Ser Tyr Asn Gln  Pro Lys Ala Met Lys  Ser Ile Leu 
    1385                 1390                 1395             


Asp His  Leu Asn Trp Val Phe  Val Val Ile Phe Thr  Leu Glu Cys 
    1400                 1405                 1410             


Leu Ile  Lys Ile Phe Ala Leu  Arg Gln Tyr Tyr Phe  Thr Asn Gly 
    1415                 1420                 1425             


Trp Asn  Leu Phe Asp Cys Val  Val Val Leu Leu Ser  Ile Val Ser 
    1430                 1435                 1440             


Thr Met  Ile Ser Thr Leu Glu  Asn Gln Glu His Ile  Pro Phe Pro 
    1445                 1450                 1455             


Pro Thr  Leu Phe Arg Ile Val  Arg Leu Ala Arg Ile  Gly Arg Ile 
    1460                 1465                 1470             


Leu Arg  Leu Val Arg Ala Ala  Arg Gly Ile Arg Thr  Leu Leu Phe 
    1475                 1480                 1485             


Ala Leu  Met Met Ser Leu Pro  Ser Leu Phe Asn Ile  Gly Leu Leu 
    1490                 1495                 1500             


Leu Phe  Leu Ile Met Phe Ile  Tyr Ala Ile Leu Gly  Met Asn Trp 
    1505                 1510                 1515             


Phe Ser  Lys Val Asn Pro Glu  Ser Gly Ile Asp Asp  Ile Phe Asn 
    1520                 1525                 1530             


Phe Lys  Thr Phe Ala Ser Ser  Met Leu Cys Leu Phe  Gln Ile Ser 
    1535                 1540                 1545             


Thr Ser  Ala Gly Trp Asp Ser  Leu Leu Ser Pro Met  Leu Arg Ser 
    1550                 1555                 1560             


Lys Glu  Ser Cys Asn Ser Ser  Ser Glu Asn Cys His  Leu Pro Gly 
    1565                 1570                 1575             


Ile Ala  Thr Ser Tyr Phe Val  Ser Tyr Ile Ile Ile  Ser Phe Leu 
    1580                 1585                 1590             


Ile Val  Val Asn Met Tyr Ile  Ala Val Ile Leu Glu  Asn Phe Asn 
    1595                 1600                 1605             


Thr Ala  Thr Glu Glu Ser Glu  Asp Pro Leu Gly Glu  Asp Asp Phe 
    1610                 1615                 1620             


Asp Ile  Phe Tyr Glu Val Trp  Glu Lys Phe Asp Pro  Glu Ala Thr 
    1625                 1630                 1635             


Gln Phe  Ile Lys Tyr Ser Ala  Leu Ser Asp Phe Ala  Asp Ala Leu 
    1640                 1645                 1650             


Pro Glu  Pro Leu Arg Val Ala  Lys Pro Asn Lys Tyr  Gln Phe Leu 
    1655                 1660                 1665             


Val Met  Asp Leu Pro Met Val  Ser Glu Asp Arg Leu  His Cys Met 
    1670                 1675                 1680             


Asp Ile  Leu Phe Ala Phe Thr  Ala Arg Val Leu Gly  Gly Ser Asp 
    1685                 1690                 1695             


Gly Leu  Asp Ser Met Lys Ala  Met Met Glu Glu Lys  Phe Met Glu 
    1700                 1705                 1710             


Ala Asn  Pro Leu Lys Lys Leu  Tyr Glu Pro Ile Val  Thr Thr Thr 
    1715                 1720                 1725             


Lys Arg  Lys Glu Glu Glu Arg  Gly Ala Ala Ile Ile  Gln Lys Ala 
    1730                 1735                 1740             


Phe Arg  Lys Tyr Met Met Lys  Val Thr Lys Gly Asp  Gln Gly Asp 
    1745                 1750                 1755             


Gln Asn  Asp Leu Glu Asn Gly  Pro His Ser Pro Leu  Gln Thr Leu 
    1760                 1765                 1770             


Cys Asn  Gly Asp Leu Ser Ser  Phe Gly Val Ala Lys  Gly Lys Val 
    1775                 1780                 1785             


His Cys  Asp 
    1790     


<210> 11
<211> 1873
<212> PRT
<213> Homo sapiens

<400> 11
Met Glu Pro Ser Ser Pro Gln Asp Glu Gly Leu Arg Lys Lys Gln Pro 
1               5                   10                  15      


Lys Lys Pro Val Pro Glu Ile Leu Pro Arg Pro Pro Arg Ala Leu Phe 
            20                  25                  30          


Cys Leu Thr Leu Glu Asn Pro Leu Arg Lys Ala Cys Ile Ser Ile Val 
        35                  40                  45              


Glu Trp Lys Pro Phe Glu Thr Ile Ile Leu Leu Thr Ile Phe Ala Asn 
    50                  55                  60                  


Cys Val Ala Leu Ala Val Tyr Leu Pro Met Pro Glu Asp Asp Asn Asn 
65                  70                  75                  80  


Ser Leu Asn Leu Gly Leu Glu Lys Leu Glu Tyr Phe Phe Leu Ile Val 
                85                  90                  95      


Phe Ser Ile Glu Ala Ala Met Lys Ile Ile Ala Tyr Gly Phe Leu Phe 
            100                 105                 110         


His Gln Asp Ala Tyr Leu Arg Ser Gly Trp Asn Val Leu Asp Phe Thr 
        115                 120                 125             


Ile Val Phe Leu Gly Val Phe Thr Val Ile Leu Glu Gln Val Asn Val 
    130                 135                 140                 


Ile Gln Ser His Thr Ala Pro Met Ser Ser Lys Gly Ala Gly Leu Asp 
145                 150                 155                 160 


Val Lys Ala Leu Arg Ala Phe Arg Val Leu Arg Pro Leu Arg Leu Val 
                165                 170                 175     


Ser Gly Val Pro Ser Leu Gln Val Val Leu Asn Ser Ile Phe Lys Ala 
            180                 185                 190         


Met Leu Pro Leu Phe His Ile Ala Leu Leu Val Leu Phe Met Val Ile 
        195                 200                 205             


Ile Tyr Ala Ile Ile Gly Leu Glu Leu Phe Lys Gly Lys Met His Lys 
    210                 215                 220                 


Thr Cys Tyr Phe Ile Gly Thr Asp Ile Val Ala Thr Val Glu Asn Glu 
225                 230                 235                 240 


Glu Pro Ser Pro Cys Ala Arg Thr Gly Ser Gly Arg Arg Cys Thr Ile 
                245                 250                 255     


Asn Gly Ser Glu Cys Arg Gly Gly Cys Pro Gly Pro Asn His Gly Ile 
            260                 265                 270         


Thr His Phe Asp Asn Phe Gly Phe Ser Met Leu Thr Val Tyr Gln Cys 
        275                 280                 285             


Ile Thr Met Glu Gly Trp Thr Asp Val Leu Tyr Trp Val Asn Asp Ala 
    290                 295                 300                 


Ile Gly Asn Glu Trp Pro Trp Ile Tyr Phe Val Thr Leu Ile Leu Leu 
305                 310                 315                 320 


Gly Ser Phe Phe Ile Leu Asn Leu Val Leu Gly Val Leu Ser Gly Glu 
                325                 330                 335     


Phe Thr Lys Glu Arg Glu Lys Ala Lys Ser Arg Gly Thr Phe Gln Lys 
            340                 345                 350         


Leu Arg Glu Lys Gln Gln Leu Asp Glu Asp Leu Arg Gly Tyr Met Ser 
        355                 360                 365             


Trp Ile Thr Gln Gly Glu Val Met Asp Val Glu Asp Phe Arg Glu Gly 
    370                 375                 380                 


Lys Leu Ser Leu Asp Glu Gly Gly Ser Asp Thr Glu Ser Leu Tyr Glu 
385                 390                 395                 400 


Ile Ala Gly Leu Asn Lys Ile Ile Gln Phe Ile Arg His Trp Arg Gln 
                405                 410                 415     


Trp Asn Arg Ile Phe Arg Trp Lys Cys His Asp Ile Val Lys Ser Lys 
            420                 425                 430         


Val Phe Tyr Trp Leu Val Ile Leu Ile Val Ala Leu Asn Thr Leu Ser 
        435                 440                 445             


Ile Ala Ser Glu His His Asn Gln Pro His Trp Leu Thr Arg Leu Gln 
    450                 455                 460                 


Asp Ile Ala Asn Arg Val Leu Leu Ser Leu Phe Thr Thr Glu Met Leu 
465                 470                 475                 480 


Met Lys Met Tyr Gly Leu Gly Leu Arg Gln Tyr Phe Met Ser Ile Phe 
                485                 490                 495     


Asn Arg Phe Asp Cys Phe Val Val Cys Ser Gly Ile Leu Glu Ile Leu 
            500                 505                 510         


Leu Val Glu Ser Gly Ala Met Thr Pro Leu Gly Ile Ser Val Leu Arg 
        515                 520                 525             


Cys Ile Arg Leu Leu Arg Ile Phe Lys Ile Thr Lys Tyr Trp Thr Ser 
    530                 535                 540                 


Leu Ser Asn Leu Val Ala Ser Leu Leu Asn Ser Ile Arg Ser Ile Ala 
545                 550                 555                 560 


Ser Leu Leu Leu Leu Leu Phe Leu Phe Ile Val Ile Phe Arg Leu Leu 
                565                 570                 575     


Gly Met Gln Leu Phe Gly Gly Arg Tyr Asp Phe Glu Asp Thr Glu Val 
            580                 585                 590         


Arg Arg Ser Asn Phe Asp Asn Phe Pro Gln Ala Leu Ile Ser Val Phe 
        595                 600                 605             


Gln Val Leu Thr Gly Glu Asp Trp Thr Ser Met Met Tyr Asn Gly Ile 
    610                 615                 620                 


Met Ala Ser Ser Gly Pro Ser Tyr Pro Gly Met Leu Val Cys Ile Tyr 
625                 630                 635                 640 


Phe Ile Ile Leu Phe Val Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe 
                645                 650                 655     


Leu Ala Ile Ala Val Asp Asn Leu Ala Glu Ala Glu Ser Leu Thr Ser 
            660                 665                 670         


Ala Gln Lys Ala Lys Ala Glu Glu Lys Lys Arg Arg Lys Met Ser Lys 
        675                 680                 685             


Gly Leu Pro Asp Lys Ser Glu Glu Glu Lys Ser Thr Met Ala Lys Lys 
    690                 695                 700                 


Leu Glu Gln Lys Pro Lys Gly Glu Gly Ile Pro Thr Thr Ala Lys Leu 
705                 710                 715                 720 


Lys Ile Asp Glu Phe Glu Ser Asn Val Asn Glu Val Lys Asp Pro Tyr 
                725                 730                 735     


Pro Ser Ala Asp Phe Pro Gly Asp Asp Glu Glu Asp Glu Pro Glu Ile 
            740                 745                 750         


Pro Leu Ser Pro Arg Pro Arg Pro Leu Ala Glu Leu Gln Leu Lys Glu 
        755                 760                 765             


Lys Ala Val Pro Ile Pro Glu Ala Ser Ser Phe Phe Ile Phe Ser Pro 
    770                 775                 780                 


Thr Asn Lys Ile Arg Val Leu Cys His Arg Ile Val Asn Ala Thr Trp 
785                 790                 795                 800 


Phe Thr Asn Phe Ile Leu Leu Phe Ile Leu Leu Ser Ser Ala Ala Leu 
                805                 810                 815     


Ala Ala Glu Asp Pro Ile Arg Ala Asp Ser Met Arg Asn Gln Ile Leu 
            820                 825                 830         


Lys His Phe Asp Ile Gly Phe Thr Ser Val Phe Thr Val Glu Ile Val 
        835                 840                 845             


Leu Lys Met Thr Thr Tyr Gly Ala Phe Leu His Lys Gly Ser Phe Cys 
    850                 855                 860                 


Arg Asn Tyr Phe Asn Met Leu Asp Leu Leu Val Val Ala Val Ser Leu 
865                 870                 875                 880 


Ile Ser Met Gly Leu Glu Ser Ser Ala Ile Ser Val Val Lys Ile Leu 
                885                 890                 895     


Arg Val Leu Arg Val Leu Arg Pro Leu Arg Ala Ile Asn Arg Ala Lys 
            900                 905                 910         


Gly Leu Lys His Val Ala Arg Cys Met Phe Val Ala Ile Ser Thr Ile 
        915                 920                 925             


Gly Asn Ile Val Leu Val Thr Thr Leu Leu Gln Phe Met Phe Ala Cys 
    930                 935                 940                 


Ile Gly Val Gln Leu Phe Lys Gly Lys Phe Phe Arg Cys Thr Asp Leu 
945                 950                 955                 960 


Ser Lys Met Thr Glu Glu Glu Cys Arg Gly Tyr Tyr Tyr Val Tyr Lys 
                965                 970                 975     


Asp Gly Asp Pro Met Gln Ile Glu Leu Arg His Arg Glu Trp Val His 
            980                 985                 990         


Ser Asp Phe His Phe Asp Asn Val  Leu Ser Ala Met Met  Ser Leu Phe 
        995                 1000                 1005             


Thr Val  Ser Thr Phe Glu Gly  Trp Pro Gln Leu Leu  Tyr Lys Ala 
    1010                 1015                 1020             


Ile Asp  Ser Asn Ala Glu Asp  Val Gly Pro Ile Tyr  Asn Asn Arg 
    1025                 1030                 1035             


Val Glu  Met Ala Ile Phe Phe  Ile Ile Tyr Ile Ile  Leu Ile Ala 
    1040                 1045                 1050             


Phe Phe  Met Met Asn Ile Phe  Val Gly Phe Val Ile  Val Thr Phe 
    1055                 1060                 1065             


Gln Glu  Gln Gly Glu Thr Glu  Tyr Lys Asn Cys Glu  Leu Asp Lys 
    1070                 1075                 1080             


Asn Gln  Arg Gln Cys Val Gln  Tyr Ala Leu Lys Ala  Arg Pro Leu 
    1085                 1090                 1095             


Arg Cys  Tyr Ile Pro Lys Asn  Pro Tyr Gln Tyr Gln  Val Trp Tyr 
    1100                 1105                 1110             


Ile Val  Thr Ser Ser Tyr Phe  Glu Tyr Leu Met Phe  Ala Leu Ile 
    1115                 1120                 1125             


Met Leu  Asn Thr Ile Cys Leu  Gly Met Gln His Tyr  Asn Gln Ser 
    1130                 1135                 1140             


Glu Gln  Met Asn His Ile Ser  Asp Ile Leu Asn Val  Ala Phe Thr 
    1145                 1150                 1155             


Ile Ile  Phe Thr Leu Glu Met  Ile Leu Lys Leu Met  Ala Phe Lys 
    1160                 1165                 1170             


Ala Arg  Gly Tyr Phe Gly Asn  Pro Trp Asn Val Phe  Asp Phe Leu 
    1175                 1180                 1185             


Ile Val  Ile Gly Ser Ile Ile  Asp Val Ile Leu Ser  Glu Ile Asp 
    1190                 1195                 1200             


Thr Phe  Leu Ala Ser Ser Gly  Gly Leu Tyr Cys Leu  Gly Gly Gly 
    1205                 1210                 1215             


Cys Gly  Asn Val Asp Pro Asp  Glu Ser Ala Arg Ile  Ser Ser Ala 
    1220                 1225                 1230             


Phe Phe  Arg Leu Phe Arg Val  Met Arg Leu Ile Lys  Leu Leu Ser 
    1235                 1240                 1245             


Arg Ala  Glu Gly Val Arg Thr  Leu Leu Trp Thr Phe  Ile Lys Ser 
    1250                 1255                 1260             


Phe Gln  Ala Leu Pro Tyr Val  Ala Leu Leu Ile Val  Met Leu Phe 
    1265                 1270                 1275             


Phe Ile  Tyr Ala Val Ile Gly  Met Gln Met Phe Gly  Lys Ile Ala 
    1280                 1285                 1290             


Leu Val  Asp Gly Thr Gln Ile  Asn Arg Asn Asn Asn  Phe Gln Thr 
    1295                 1300                 1305             


Phe Pro  Gln Ala Val Leu Leu  Leu Phe Arg Cys Ala  Thr Gly Glu 
    1310                 1315                 1320             


Ala Trp  Gln Glu Ile Leu Leu  Ala Cys Ser Tyr Gly  Lys Leu Cys 
    1325                 1330                 1335             


Asp Pro  Glu Ser Asp Tyr Ala  Pro Gly Glu Glu Tyr  Thr Cys Gly 
    1340                 1345                 1350             


Thr Asn  Phe Ala Tyr Tyr Tyr  Phe Ile Ser Phe Tyr  Met Leu Cys 
    1355                 1360                 1365             


Ala Phe  Leu Val Ile Asn Leu  Phe Val Ala Val Ile  Met Asp Asn 
    1370                 1375                 1380             


Phe Asp  Tyr Leu Thr Arg Asp  Trp Ser Ile Leu Gly  Pro His His 
    1385                 1390                 1395             


Leu Asp  Glu Phe Lys Ala Ile  Trp Ala Glu Tyr Asp  Pro Glu Ala 
    1400                 1405                 1410             


Lys Gly  Arg Ile Lys His Leu  Asp Val Val Thr Leu  Leu Arg Arg 
    1415                 1420                 1425             


Ile Gln  Pro Pro Leu Gly Phe  Gly Lys Phe Cys Pro  His Arg Val 
    1430                 1435                 1440             


Ala Cys  Lys Arg Leu Val Gly  Met Asn Met Pro Leu  Asn Ser Asp 
    1445                 1450                 1455             


Gly Thr  Val Thr Phe Asn Ala  Thr Leu Phe Ala Leu  Val Arg Thr 
    1460                 1465                 1470             


Ala Leu  Lys Ile Lys Thr Glu  Gly Asn Phe Glu Gln  Ala Asn Glu 
    1475                 1480                 1485             


Glu Leu  Arg Ala Ile Ile Lys  Lys Ile Trp Lys Arg  Thr Ser Met 
    1490                 1495                 1500             


Lys Leu  Leu Asp Gln Val Ile  Pro Pro Ile Gly Asp  Asp Glu Val 
    1505                 1510                 1515             


Thr Val  Gly Lys Phe Tyr Ala  Thr Phe Leu Ile Gln  Glu His Phe 
    1520                 1525                 1530             


Arg Lys  Phe Met Lys Arg Gln  Glu Glu Tyr Tyr Gly  Tyr Arg Pro 
    1535                 1540                 1545             


Lys Lys  Asp Ile Val Gln Ile  Gln Ala Gly Leu Arg  Thr Ile Glu 
    1550                 1555                 1560             


Glu Glu  Ala Ala Pro Glu Ile  Cys Arg Thr Val Ser  Gly Asp Leu 
    1565                 1570                 1575             


Ala Ala  Glu Glu Glu Leu Glu  Arg Ala Met Val Glu  Ala Ala Met 
    1580                 1585                 1590             


Glu Glu  Gly Ile Phe Arg Arg  Thr Gly Gly Leu Phe  Gly Gln Val 
    1595                 1600                 1605             


Asp Asn  Phe Leu Glu Arg Thr  Asn Ser Leu Pro Pro  Val Met Ala 
    1610                 1615                 1620             


Asn Gln  Arg Pro Leu Gln Phe  Ala Glu Ile Glu Met  Glu Glu Met 
    1625                 1630                 1635             


Glu Ser  Pro Val Phe Leu Glu  Asp Phe Pro Gln Asp  Pro Arg Thr 
    1640                 1645                 1650             


Asn Pro  Leu Ala Arg Ala Asn  Thr Asn Asn Ala Asn  Ala Asn Val 
    1655                 1660                 1665             


Ala Tyr  Ala Asn Ser Asn His  Ser Asn Ser His Val  Phe Ser Ser 
    1670                 1675                 1680             


Val His  Tyr Glu Arg Glu Phe  Pro Glu Glu Thr Glu  Thr Pro Ala 
    1685                 1690                 1695             


Thr Arg  Gly Arg Ala Leu Gly  Gln Pro Cys Arg Ser  Leu Gly Pro 
    1700                 1705                 1710             


His Ser  Lys Pro Cys Val Glu  Met Leu Lys Gly Leu  Leu Thr Gln 
    1715                 1720                 1725             


Arg Ala  Met Pro Arg Gly Gln  Ala Pro Pro Ala Pro  Cys Gln Cys 
    1730                 1735                 1740             


Pro Arg  Val Glu Ser Ser Met  Pro Glu Asp Arg Lys  Ser Ser Thr 
    1745                 1750                 1755             


Pro Gly  Ser Leu His Glu Glu  Thr Pro His Ser Arg  Ser Thr Arg 
    1760                 1765                 1770             


Glu Asn  Thr Ser Arg Cys Ser  Ala Pro Ala Thr Ala  Leu Leu Ile 
    1775                 1780                 1785             


Gln Lys  Ala Leu Val Arg Gly  Gly Leu Gly Thr Leu  Ala Ala Asp 
    1790                 1795                 1800             


Ala Asn  Phe Ile Met Ala Thr  Gly Gln Ala Leu Gly  Asp Ala Cys 
    1805                 1810                 1815             


Gln Met  Glu Pro Glu Glu Val  Glu Ile Met Ala Thr  Glu Leu Leu 
    1820                 1825                 1830             


Lys Gly  Arg Glu Ala Pro Asp  Gly Met Ala Ser Ser  Leu Gly Cys 
    1835                 1840                 1845             


Leu Asn  Leu Gly Ser Ser Leu  Gly Ser Leu Asp Gln  His Gln Gly 
    1850                 1855                 1860             


Ser Gln  Glu Thr Leu Ile Pro  Pro Arg Leu 
    1865                 1870             


<210> 12
<211> 2169
<212> PRT
<213> Homo sapiens

<400> 12
Met Asn Ala Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Thr 
1               5                   10                  15      


Pro Gly Ala Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln 
            20                  25                  30          


Ala Lys Leu Met Gly Ser Ala Gly Asn Ala Thr Ile Ser Thr Val Ser 
        35                  40                  45              


Ser Thr Gln Arg Lys Arg Arg Gln Tyr Gly Lys Pro Lys Lys Gln Gly 
    50                  55                  60                  


Ser Thr Thr Ala Thr Arg Pro Pro Arg Ala Leu Leu Cys Leu Thr Leu 
65                  70                  75                  80  


Lys Asn Pro Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro 
                85                  90                  95      


Phe Glu Ile Ile Ile Leu Leu Thr Ile Phe Ala Asn Cys Val Ala Leu 
            100                 105                 110         


Ala Ile Tyr Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Thr Asn Ser 
        115                 120                 125             


Asn Leu Glu Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Thr Val Glu 
    130                 135                 140                 


Ala Phe Leu Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala 
145                 150                 155                 160 


Tyr Leu Arg Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val 
                165                 170                 175     


Gly Leu Phe Ser Ala Ile Leu Glu Gln Ala Thr Lys Ala Asp Gly Ala 
            180                 185                 190         


Asn Ala Leu Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg 
        195                 200                 205             


Ala Phe Arg Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser 
    210                 215                 220                 


Leu Gln Val Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu 
225                 230                 235                 240 


His Ile Ala Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile 
                245                 250                 255     


Gly Leu Glu Leu Phe Met Gly Lys Met His Lys Thr Cys Tyr Asn Gln 
            260                 265                 270         


Glu Gly Ile Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala 
        275                 280                 285             


Leu Glu Thr Gly His Gly Arg Gln Cys Gln Asn Gly Thr Val Cys Lys 
    290                 295                 300                 


Pro Gly Trp Asp Gly Pro Lys His Gly Ile Thr Asn Phe Asp Asn Phe 
305                 310                 315                 320 


Ala Phe Ala Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp 
                325                 330                 335     


Thr Asp Val Leu Tyr Trp Met Gln Asp Ala Met Gly Tyr Glu Leu Pro 
            340                 345                 350         


Trp Val Tyr Phe Val Ser Leu Val Ile Phe Gly Ser Phe Phe Val Leu 
        355                 360                 365             


Asn Leu Val Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu 
    370                 375                 380                 


Lys Ala Lys Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln 
385                 390                 395                 400 


Leu Glu Glu Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu 
                405                 410                 415     


Asp Ile Asp Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro 
            420                 425                 430         


Arg Asn Met Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu 
        435                 440                 445             


Asn Val Ala Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu 
    450                 455                 460                 


Ala His Arg Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp 
465                 470                 475                 480 


Asn Arg Phe Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val 
                485                 490                 495     


Phe Tyr Trp Leu Val Ile Phe Leu Val Phe Leu Asn Thr Leu Thr Ile 
            500                 505                 510         


Ala Ser Glu His Tyr Asn Gln Pro Asn Trp Leu Thr Glu Val Gln Asp 
        515                 520                 525             


Thr Ala Asn Lys Ala Leu Leu Ala Leu Phe Thr Ala Glu Met Leu Leu 
    530                 535                 540                 


Lys Met Tyr Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn 
545                 550                 555                 560 


Arg Phe Asp Cys Phe Val Val Cys Gly Gly Ile Leu Glu Thr Ile Leu 
                565                 570                 575     


Val Glu Thr Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys 
            580                 585                 590         


Val Arg Leu Leu Arg Ile Phe Lys Ile Thr Arg Tyr Trp Asn Ser Leu 
        595                 600                 605             


Ser Asn Leu Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser 
    610                 615                 620                 


Leu Leu Leu Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly 
625                 630                 635                 640 


Met Gln Leu Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Thr Arg 
                645                 650                 655     


Arg Ser Thr Phe Asp Asn Phe Pro Gln Ser Leu Leu Thr Val Phe Gln 
            660                 665                 670         


Ile Leu Thr Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met 
        675                 680                 685             


Ala Tyr Gly Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe 
    690                 695                 700                 


Ile Ile Leu Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu 
705                 710                 715                 720 


Ala Ile Ala Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Thr Ser Ala 
                725                 730                 735     


Gln Lys Glu Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Thr 
            740                 745                 750         


Ala Ser Pro Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly 
        755                 760                 765             


Glu Ser Lys Glu Glu Lys Ile Glu Leu Lys Ser Ile Thr Ala Asp Gly 
    770                 775                 780                 


Glu Ser Pro Pro Ala Thr Lys Ile Asn Met Asp Asp Leu Gln Pro Asn 
785                 790                 795                 800 


Glu Asn Glu Asp Lys Ser Pro Tyr Pro Asn Pro Glu Thr Thr Gly Glu 
                805                 810                 815     


Glu Asp Glu Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro 
            820                 825                 830         


Leu Ser Glu Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala 
        835                 840                 845             


Ser Ala Phe Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys 
    850                 855                 860                 


His Arg Ile Val Asn Asp Thr Ile Phe Thr Asn Leu Ile Leu Phe Phe 
865                 870                 875                 880 


Ile Leu Leu Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His 
                885                 890                 895     


Thr Ser Phe Arg Asn His Ile Leu Phe Tyr Phe Asp Ile Val Phe Thr 
            900                 905                 910         


Thr Ile Phe Thr Ile Glu Ile Ala Leu Lys Met Thr Ala Tyr Gly Ala 
        915                 920                 925             


Phe Leu His Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu Asp 
    930                 935                 940                 


Leu Leu Val Val Ser Val Ser Leu Ile Ser Phe Gly Ile Gln Ser Ser 
945                 950                 955                 960 


Ala Ile Asn Val Val Lys Ile Leu Arg Val Leu Arg Val Leu Arg Pro 
                965                 970                 975     


Leu Arg Ala Ile Asn Arg Ala Lys Gly Leu Lys His Val Val Gln Cys 
            980                 985                 990         


Val Phe Val Ala Ile Arg Thr Ile  Gly Asn Ile Val Ile  Val Thr Thr 
        995                 1000                 1005             


Leu Leu  Gln Phe Met Phe Ala  Cys Ile Gly Val Gln  Leu Phe Lys 
    1010                 1015                 1020             


Gly Lys  Leu Tyr Thr Cys Ser  Asp Ser Ser Lys Gln  Thr Glu Ala 
    1025                 1030                 1035             


Glu Cys  Lys Gly Asn Tyr Ile  Thr Tyr Lys Asp Gly  Glu Val Asp 
    1040                 1045                 1050             


His Pro  Ile Ile Gln Pro Arg  Ser Trp Glu Asn Ser  Lys Phe Asp 
    1055                 1060                 1065             


Phe Asp  Asn Val Leu Ala Ala  Met Met Ala Leu Phe  Thr Val Ser 
    1070                 1075                 1080             


Thr Phe  Glu Gly Trp Pro Glu  Leu Leu Tyr Arg Ser  Ile Asp Ser 
    1085                 1090                 1095             


His Thr  Glu Asp Lys Gly Pro  Ile Tyr Asn Tyr Arg  Val Glu Ile 
    1100                 1105                 1110             


Ser Ile  Phe Phe Ile Ile Tyr  Ile Ile Ile Ile Ala  Phe Phe Met 
    1115                 1120                 1125             


Met Asn  Ile Phe Val Gly Phe  Val Ile Val Thr Phe  Gln Glu Gln 
    1130                 1135                 1140             


Gly Glu  Gln Glu Tyr Lys Asn  Cys Glu Leu Asp Lys  Asn Gln Arg 
    1145                 1150                 1155             


Gln Cys  Val Glu Tyr Ala Leu  Lys Ala Arg Pro Leu  Arg Arg Tyr 
    1160                 1165                 1170             


Ile Pro  Lys Asn Gln His Gln  Tyr Lys Val Trp Tyr  Val Val Asn 
    1175                 1180                 1185             


Ser Thr  Tyr Phe Glu Tyr Leu  Met Phe Val Leu Ile  Leu Leu Asn 
    1190                 1195                 1200             


Thr Ile  Cys Leu Ala Met Gln  His Tyr Gly Gln Ser  Cys Leu Phe 
    1205                 1210                 1215             


Lys Ile  Ala Met Asn Ile Leu  Asn Met Leu Phe Thr  Gly Leu Phe 
    1220                 1225                 1230             


Thr Val  Glu Met Ile Leu Lys  Leu Ile Ala Phe Lys  Pro Lys His 
    1235                 1240                 1245             


Tyr Phe  Cys Asp Ala Trp Asn  Thr Phe Asp Ala Leu  Ile Val Val 
    1250                 1255                 1260             


Gly Ser  Ile Val Asp Ile Ala  Ile Thr Glu Val Asn  Asn Ala Glu 
    1265                 1270                 1275             


Glu Asn  Ser Arg Ile Ser Ile  Thr Phe Phe Arg Leu  Phe Arg Val 
    1280                 1285                 1290             


Met Arg  Leu Val Lys Leu Leu  Ser Arg Gly Glu Gly  Ile Arg Thr 
    1295                 1300                 1305             


Leu Leu  Trp Thr Phe Ile Lys  Ser Phe Gln Ala Leu  Pro Tyr Val 
    1310                 1315                 1320             


Ala Leu  Leu Ile Val Met Leu  Phe Phe Ile Tyr Ala  Val Ile Gly 
    1325                 1330                 1335             


Met Gln  Val Phe Gly Lys Ile  Ala Leu Asn Asp Thr  Thr Glu Ile 
    1340                 1345                 1350             


Asn Arg  Asn Asn Asn Phe Gln  Thr Phe Pro Gln Ala  Val Leu Leu 
    1355                 1360                 1365             


Leu Phe  Arg Cys Ala Thr Gly  Glu Ala Trp Gln Asp  Ile Met Leu 
    1370                 1375                 1380             


Ala Cys  Met Pro Gly Lys Lys  Cys Ala Pro Glu Ser  Glu Pro Ser 
    1385                 1390                 1395             


Asn Ser  Thr Glu Gly Glu Thr  Pro Cys Gly Ser Ser  Phe Ala Val 
    1400                 1405                 1410             


Phe Tyr  Phe Ile Ser Phe Tyr  Met Leu Cys Ala Phe  Leu Ile Ile 
    1415                 1420                 1425             


Asn Leu  Phe Val Ala Val Ile  Met Asp Asn Phe Asp  Tyr Leu Thr 
    1430                 1435                 1440             


Arg Asp  Trp Ser Ile Leu Gly  Pro His His Leu Asp  Glu Phe Lys 
    1445                 1450                 1455             


Arg Ile  Trp Ala Glu Tyr Asp  Pro Glu Ala Lys Gly  Arg Ile Lys 
    1460                 1465                 1470             


His Leu  Asp Val Val Thr Leu  Leu Arg Arg Ile Gln  Pro Pro Leu 
    1475                 1480                 1485             


Gly Phe  Gly Lys Leu Cys Pro  His Arg Val Ala Cys  Lys Arg Leu 
    1490                 1495                 1500             


Val Ser  Met Asn Met Pro Leu  Asn Ser Asp Gly Thr  Val Met Phe 
    1505                 1510                 1515             


Asn Ala  Thr Leu Phe Ala Leu  Val Arg Thr Ala Leu  Arg Ile Lys 
    1520                 1525                 1530             


Thr Glu  Gly Asn Leu Glu Gln  Ala Asn Glu Glu Leu  Arg Ala Ile 
    1535                 1540                 1545             


Ile Lys  Lys Ile Trp Lys Arg  Thr Ser Met Lys Leu  Leu Asp Gln 
    1550                 1555                 1560             


Val Val  Pro Pro Ala Gly Asp  Asp Glu Val Thr Val  Gly Lys Phe 
    1565                 1570                 1575             


Tyr Ala  Thr Phe Leu Ile Gln  Glu Tyr Phe Arg Lys  Phe Lys Lys 
    1580                 1585                 1590             


Arg Lys  Glu Gln Gly Leu Val  Gly Lys Pro Ser Gln  Arg Asn Ala 
    1595                 1600                 1605             


Leu Ser  Leu Gln Ala Gly Leu  Arg Thr Leu His Asp  Ile Gly Pro 
    1610                 1615                 1620             


Glu Ile  Arg Arg Ala Ile Ser  Gly Asp Leu Thr Ala  Glu Glu Glu 
    1625                 1630                 1635             


Leu Asp  Lys Ala Met Lys Glu  Ala Val Ser Ala Ala  Ser Glu Asp 
    1640                 1645                 1650             


Asp Ile  Phe Arg Arg Ala Gly  Gly Leu Phe Gly Asn  His Val Ser 
    1655                 1660                 1665             


Tyr Tyr  Gln Ser Asp Gly Arg  Ser Ala Phe Pro Gln  Thr Phe Thr 
    1670                 1675                 1680             


Thr Gln  Arg Pro Leu His Ile  Asn Lys Ala Gly Ser  Ser Gln Gly 
    1685                 1690                 1695             


Asp Thr  Glu Ser Pro Ser His  Glu Lys Leu Val Asp  Ser Thr Phe 
    1700                 1705                 1710             


Thr Pro  Ser Ser Tyr Ser Ser  Thr Gly Ser Asn Ala  Asn Ile Asn 
    1715                 1720                 1725             


Asn Ala  Asn Asn Thr Ala Leu  Gly Arg Leu Pro Arg  Pro Ala Gly 
    1730                 1735                 1740             


Tyr Pro  Ser Thr Val Ser Thr  Val Glu Gly His Gly  Pro Pro Leu 
    1745                 1750                 1755             


Ser Pro  Ala Ile Arg Val Gln  Glu Val Ala Trp Lys  Leu Ser Ser 
    1760                 1765                 1770             


Asn Arg  Met His Cys Cys Asp  Met Leu Asp Gly Gly  Thr Phe Pro 
    1775                 1780                 1785             


Pro Ala  Leu Gly Pro Arg Arg  Ala Pro Pro Cys Leu  His Gln Gln 
    1790                 1795                 1800             


Leu Gln  Gly Ser Leu Ala Gly  Leu Arg Glu Asp Thr  Pro Cys Ile 
    1805                 1810                 1815             


Val Pro  Gly His Ala Ser Leu  Cys Cys Ser Ser Arg  Val Gly Glu 
    1820                 1825                 1830             


Trp Leu  Pro Ala Gly Cys Thr  Ala Pro Gln His Ala  Arg Cys His 
    1835                 1840                 1845             


Ser Arg  Glu Ser Gln Ala Ala  Met Ala Gly Gln Glu  Glu Thr Ser 
    1850                 1855                 1860             


Gln Asp  Glu Thr Tyr Glu Val  Lys Met Asn His Asp  Thr Glu Ala 
    1865                 1870                 1875             


Cys Ser  Glu Pro Ser Leu Leu  Ser Thr Glu Met Leu  Ser Tyr Gln 
    1880                 1885                 1890             


Asp Asp  Glu Asn Arg Gln Leu  Thr Leu Pro Glu Glu  Asp Lys Arg 
    1895                 1900                 1905             


Asp Ile  Arg Gln Ser Pro Lys  Arg Gly Phe Leu Arg  Ser Ala Ser 
    1910                 1915                 1920             


Leu Gly  Arg Arg Ala Ser Phe  His Leu Glu Cys Leu  Lys Arg Gln 
    1925                 1930                 1935             


Lys Asp  Arg Gly Gly Asp Ile  Ser Gln Lys Thr Val  Leu Pro Leu 
    1940                 1945                 1950             


His Leu  Val His His Gln Ala  Leu Ala Val Ala Gly  Leu Ser Pro 
    1955                 1960                 1965             


Leu Leu  Gln Arg Ser His Ser  Pro Ala Ser Phe Pro  Arg Pro Phe 
    1970                 1975                 1980             


Ala Thr  Pro Pro Ala Thr Pro  Gly Ser Arg Gly Trp  Pro Pro Gln 
    1985                 1990                 1995             


Pro Val  Pro Thr Leu Arg Leu  Glu Gly Val Glu Ser  Ser Glu Lys 
    2000                 2005                 2010             


Leu Asn  Ser Ser Phe Pro Ser  Ile His Cys Gly Ser  Trp Ala Glu 
    2015                 2020                 2025             


Thr Thr  Pro Gly Gly Gly Gly  Ser Ser Ala Ala Arg  Arg Val Arg 
    2030                 2035                 2040             


Pro Val  Ser Leu Met Val Pro  Ser Gln Ala Gly Ala  Pro Gly Arg 
    2045                 2050                 2055             


Gln Phe  His Gly Ser Ala Ser  Ser Leu Val Glu Ala  Val Leu Ile 
    2060                 2065                 2070             


Ser Glu  Gly Leu Gly Gln Phe  Ala Gln Asp Pro Lys  Phe Ile Glu 
    2075                 2080                 2085             


Val Thr  Thr Gln Glu Leu Ala  Asp Ala Cys Asp Met  Thr Ile Glu 
    2090                 2095                 2100             


Glu Met  Glu Ser Ala Ala Asp  Asn Ile Leu Ser Gly  Gly Ala Pro 
    2105                 2110                 2115             


Gln Ser  Pro Asn Gly Ala Leu  Leu Pro Phe Val Asn  Cys Arg Asp 
    2120                 2125                 2130             


Ala Gly  Gln Asp Arg Ala Gly  Gly Glu Glu Asp Ala  Gly Cys Val 
    2135                 2140                 2145             


Arg Ala  Arg Gly Arg Pro Ser  Glu Glu Glu Leu Gln  Asp Ser Arg 
    2150                 2155                 2160             


Val Tyr  Val Ser Ser Leu 
    2165                 


<210> 13
<211> 2161
<212> PRT
<213> Homo sapiens

<400> 13
Met Met Met Met Met Met Met Lys Lys Met Gln His Gln Arg Gln Gln 
1               5                   10                  15      


Gln Ala Asp His Ala Asn Glu Ala Asn Tyr Ala Arg Gly Thr Arg Leu 
            20                  25                  30          


Pro Leu Ser Gly Glu Gly Pro Thr Ser Gln Pro Asn Ser Ser Lys Gln 
        35                  40                  45              


Thr Val Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys 
    50                  55                  60                  


Ala Ala Gln Thr Met Ser Thr Ser Ala Pro Pro Pro Val Gly Ser Leu 
65                  70                  75                  80  


Ser Gln Arg Lys Arg Gln Gln Tyr Ala Lys Ser Lys Lys Gln Gly Asn 
                85                  90                  95      


Ser Ser Asn Ser Arg Pro Ala Arg Ala Leu Phe Cys Leu Ser Leu Asn 
            100                 105                 110         


Asn Pro Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe 
        115                 120                 125             


Asp Ile Phe Ile Leu Leu Ala Ile Phe Ala Asn Cys Val Ala Leu Ala 
    130                 135                 140                 


Ile Tyr Ile Pro Phe Pro Glu Asp Asp Ser Asn Ser Thr Asn His Asn 
145                 150                 155                 160 


Leu Glu Lys Val Glu Tyr Ala Phe Leu Ile Ile Phe Thr Val Glu Thr 
                165                 170                 175     


Phe Leu Lys Ile Ile Ala Tyr Gly Leu Leu Leu His Pro Asn Ala Tyr 
            180                 185                 190         


Val Arg Asn Gly Trp Asn Leu Leu Asp Phe Val Ile Val Ile Val Gly 
        195                 200                 205             


Leu Phe Ser Val Ile Leu Glu Gln Leu Thr Lys Glu Thr Glu Gly Gly 
    210                 215                 220                 


Asn His Ser Ser Gly Lys Ser Gly Gly Phe Asp Val Lys Ala Leu Arg 
225                 230                 235                 240 


Ala Phe Arg Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser 
                245                 250                 255     


Leu Gln Val Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu 
            260                 265                 270         


His Ile Ala Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile 
        275                 280                 285             


Gly Leu Glu Leu Phe Ile Gly Lys Met His Lys Thr Cys Phe Phe Ala 
    290                 295                 300                 


Asp Ser Asp Ile Val Ala Glu Glu Asp Pro Ala Pro Cys Ala Phe Ser 
305                 310                 315                 320 


Gly Asn Gly Arg Gln Cys Thr Ala Asn Gly Thr Glu Cys Arg Ser Gly 
                325                 330                 335     


Trp Val Gly Pro Asn Gly Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe 
            340                 345                 350         


Ala Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp 
        355                 360                 365             


Val Leu Tyr Trp Met Asn Asp Ala Met Gly Phe Glu Leu Pro Trp Val 
    370                 375                 380                 


Tyr Phe Val Ser Leu Val Ile Phe Gly Ser Phe Phe Val Leu Asn Leu 
385                 390                 395                 400 


Val Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala 
                405                 410                 415     


Lys Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu 
            420                 425                 430         


Glu Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile 
        435                 440                 445             


Asp Pro Glu Asn Glu Glu Glu Gly Gly Glu Glu Gly Lys Arg Asn Thr 
    450                 455                 460                 


Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ser 
465                 470                 475                 480 


Gly Glu Gly Glu Asn Arg Gly Cys Cys Gly Ser Leu Cys Gln Ala Ile 
                485                 490                 495     


Ser Lys Ser Lys Leu Ser Arg Arg Trp Arg Arg Trp Asn Arg Phe Asn 
            500                 505                 510         


Arg Arg Arg Cys Arg Ala Ala Val Lys Ser Val Thr Phe Tyr Trp Leu 
        515                 520                 525             


Val Ile Val Leu Val Phe Leu Asn Thr Leu Thr Ile Ser Ser Glu His 
    530                 535                 540                 


Tyr Asn Gln Pro Asp Trp Leu Thr Gln Ile Gln Asp Ile Ala Asn Lys 
545                 550                 555                 560 


Val Leu Leu Ala Leu Phe Thr Cys Glu Met Leu Val Lys Met Tyr Ser 
                565                 570                 575     


Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp Cys 
            580                 585                 590         


Phe Val Val Cys Gly Gly Ile Thr Glu Thr Ile Leu Val Glu Leu Glu 
        595                 600                 605             


Ile Met Ser Pro Leu Gly Ile Ser Val Phe Arg Cys Val Arg Leu Leu 
    610                 615                 620                 


Arg Ile Phe Lys Val Thr Arg His Trp Thr Ser Leu Cys Asn Leu Val 
625                 630                 635                 640 


Ala Ser Leu Leu Asn Ser Met Lys Ser Ser Ala Ser Leu Leu Leu Leu 
                645                 650                 655     


Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu Phe 
            660                 665                 670         


Gly Gly Lys Phe Asn Phe Asp Glu Thr Gln Thr Lys Arg Ser Thr Phe 
        675                 680                 685             


Asp Asn Phe Pro Gln Ala Leu Leu Thr Val Phe Gln Ile Leu Thr Gly 
    690                 695                 700                 


Glu Asp Trp Asn Ala Val Met Tyr Asp Gly Ile Met Ala Tyr Gly Gly 
705                 710                 715                 720 


Pro Ser Ser Ser Gly Met Ile Val Cys Ile Tyr Phe Ile Ile Leu Phe 
                725                 730                 735     


Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala Val 
            740                 745                 750         


Asp Asn Leu Ala Asp Ala Glu Ser Leu Asn Thr Ala Gln Lys Glu Glu 
        755                 760                 765             


Ala Glu Glu Lys Glu Arg Lys Lys Ile Ala Arg Lys Glu Ser Leu Glu 
    770                 775                 780                 


Asn Lys Lys Asn Asn Lys Pro Glu Val Asn Gln Ile Ala Asn Ser Asp 
785                 790                 795                 800 


Asn Lys Val Thr Ile Asp Asp Tyr Arg Glu Glu Asp Glu Asp Lys Asp 
                805                 810                 815     


Pro Tyr Pro Pro Cys Asp Val Pro Val Gly Glu Glu Glu Glu Glu Glu 
            820                 825                 830         


Glu Glu Asp Glu Pro Glu Val Pro Ala Gly Pro Arg Pro Arg Arg Ile 
        835                 840                 845             


Ser Glu Leu Asn Met Lys Glu Lys Ile Ala Pro Ile Pro Glu Gly Ser 
    850                 855                 860                 


Ala Phe Phe Ile Leu Ser Lys Thr Asn Pro Ile Arg Val Gly Cys His 
865                 870                 875                 880 


Lys Leu Ile Asn His His Ile Phe Thr Asn Leu Ile Leu Val Phe Ile 
                885                 890                 895     


Met Leu Ser Ser Ala Ala Leu Ala Ala Glu Asp Pro Ile Arg Ser His 
            900                 905                 910         


Ser Phe Arg Asn Thr Ile Leu Gly Tyr Phe Asp Tyr Ala Phe Thr Ala 
        915                 920                 925             


Ile Phe Thr Val Glu Ile Leu Leu Lys Met Thr Thr Phe Gly Ala Phe 
    930                 935                 940                 


Leu His Lys Gly Ala Phe Cys Arg Asn Tyr Phe Asn Leu Leu Asp Met 
945                 950                 955                 960 


Leu Val Val Gly Val Ser Leu Val Ser Phe Gly Ile Gln Ser Ser Ala 
                965                 970                 975     


Ile Ser Val Val Lys Ile Leu Arg Val Leu Arg Val Leu Arg Pro Leu 
            980                 985                 990         


Arg Ala Ile Asn Arg Ala Lys Gly  Leu Lys His Val Val  Gln Cys Val 
        995                 1000                 1005             


Phe Val  Ala Ile Arg Thr Ile  Gly Asn Ile Met Ile  Val Thr Thr 
    1010                 1015                 1020             


Leu Leu  Gln Phe Met Phe Ala  Cys Ile Gly Val Gln  Leu Phe Lys 
    1025                 1030                 1035             


Gly Lys  Phe Tyr Arg Cys Thr  Asp Glu Ala Lys Ser  Asn Pro Glu 
    1040                 1045                 1050             


Glu Cys  Arg Gly Leu Phe Ile  Leu Tyr Lys Asp Gly  Asp Val Asp 
    1055                 1060                 1065             


Ser Pro  Val Val Arg Glu Arg  Ile Trp Gln Asn Ser  Asp Phe Asn 
    1070                 1075                 1080             


Phe Asp  Asn Val Leu Ser Ala  Met Met Ala Leu Phe  Thr Val Ser 
    1085                 1090                 1095             


Thr Phe  Glu Gly Trp Pro Ala  Leu Leu Tyr Lys Ala  Ile Asp Ser 
    1100                 1105                 1110             


Asn Gly  Glu Asn Ile Gly Pro  Ile Tyr Asn His Arg  Val Glu Ile 
    1115                 1120                 1125             


Ser Ile  Phe Phe Ile Ile Tyr  Ile Ile Ile Val Ala  Phe Phe Met 
    1130                 1135                 1140             


Met Asn  Ile Phe Val Gly Phe  Val Ile Val Thr Phe  Gln Glu Gln 
    1145                 1150                 1155             


Gly Glu  Lys Glu Tyr Lys Asn  Cys Glu Leu Asp Lys  Asn Gln Arg 
    1160                 1165                 1170             


Gln Cys  Val Glu Tyr Ala Leu  Lys Ala Arg Pro Leu  Arg Arg Tyr 
    1175                 1180                 1185             


Ile Pro  Lys Asn Pro Tyr Gln  Tyr Lys Phe Trp Tyr  Val Val Asn 
    1190                 1195                 1200             


Ser Ser  Pro Phe Glu Tyr Met  Met Phe Val Leu Ile  Met Leu Asn 
    1205                 1210                 1215             


Thr Leu  Cys Leu Ala Met Gln  His Tyr Glu Gln Ser  Lys Met Phe 
    1220                 1225                 1230             


Asn Asp  Ala Met Asp Ile Leu  Asn Met Val Phe Thr  Gly Val Phe 
    1235                 1240                 1245             


Thr Val  Glu Met Val Leu Lys  Val Ile Ala Phe Lys  Pro Lys Gly 
    1250                 1255                 1260             


Tyr Phe  Ser Asp Ala Trp Asn  Thr Phe Asp Ser Leu  Ile Val Ile 
    1265                 1270                 1275             


Gly Ser  Ile Ile Asp Val Ala  Leu Ser Glu Ala Asp  Pro Thr Glu 
    1280                 1285                 1290             


Ser Glu  Asn Val Pro Val Pro  Thr Ala Thr Pro Gly  Asn Ser Glu 
    1295                 1300                 1305             


Glu Ser  Asn Arg Ile Ser Ile  Thr Phe Phe Arg Leu  Phe Arg Val 
    1310                 1315                 1320             


Met Arg  Leu Val Lys Leu Leu  Ser Arg Gly Glu Gly  Ile Arg Thr 
    1325                 1330                 1335             


Leu Leu  Trp Thr Phe Ile Lys  Phe Phe Gln Ala Leu  Pro Tyr Val 
    1340                 1345                 1350             


Ala Leu  Leu Ile Ala Met Leu  Phe Phe Ile Tyr Ala  Val Ile Gly 
    1355                 1360                 1365             


Met Gln  Met Phe Gly Lys Val  Ala Met Arg Asp Asn  Asn Gln Ile 
    1370                 1375                 1380             


Asn Arg  Asn Asn Asn Phe Gln  Thr Phe Pro Gln Ala  Val Leu Leu 
    1385                 1390                 1395             


Leu Phe  Arg Cys Ala Thr Gly  Glu Ala Trp Gln Glu  Ile Met Leu 
    1400                 1405                 1410             


Ala Cys  Leu Pro Gly Lys Leu  Cys Asp Pro Glu Ser  Asp Tyr Asn 
    1415                 1420                 1425             


Pro Gly  Glu Glu His Thr Cys  Gly Ser Asn Phe Ala  Ile Val Tyr 
    1430                 1435                 1440             


Phe Ile  Ser Phe Tyr Met Leu  Cys Ala Phe Leu Ile  Ile Asn Leu 
    1445                 1450                 1455             


Phe Val  Ala Val Ile Met Asp  Asn Phe Asp Tyr Leu  Thr Arg Asp 
    1460                 1465                 1470             


Trp Ser  Ile Leu Gly Pro His  His Leu Asp Glu Phe  Lys Arg Ile 
    1475                 1480                 1485             


Trp Ser  Glu Tyr Asp Pro Glu  Ala Lys Gly Arg Ile  Lys His Leu 
    1490                 1495                 1500             


Asp Val  Val Thr Leu Leu Arg  Arg Ile Gln Pro Pro  Leu Gly Phe 
    1505                 1510                 1515             


Gly Lys  Leu Cys Pro His Arg  Val Ala Cys Lys Arg  Leu Val Ala 
    1520                 1525                 1530             


Met Asn  Met Pro Leu Asn Ser  Asp Gly Thr Val Met  Phe Asn Ala 
    1535                 1540                 1545             


Thr Leu  Phe Ala Leu Val Arg  Thr Ala Leu Lys Ile  Lys Thr Glu 
    1550                 1555                 1560             


Gly Asn  Leu Glu Gln Ala Asn  Glu Glu Leu Arg Ala  Val Ile Lys 
    1565                 1570                 1575             


Lys Ile  Trp Lys Lys Thr Ser  Met Lys Leu Leu Asp  Gln Val Val 
    1580                 1585                 1590             


Pro Pro  Ala Gly Asp Asp Glu  Val Thr Val Gly Lys  Phe Tyr Ala 
    1595                 1600                 1605             


Thr Phe  Leu Ile Gln Asp Tyr  Phe Arg Lys Phe Lys  Lys Arg Lys 
    1610                 1615                 1620             


Glu Gln  Gly Leu Val Gly Lys  Tyr Pro Ala Lys Asn  Thr Thr Ile 
    1625                 1630                 1635             


Ala Leu  Gln Ala Gly Leu Arg  Thr Leu His Asp Ile  Gly Pro Glu 
    1640                 1645                 1650             


Ile Arg  Arg Ala Ile Ser Cys  Asp Leu Gln Asp Asp  Glu Pro Glu 
    1655                 1660                 1665             


Glu Thr  Lys Arg Glu Glu Glu  Asp Asp Val Phe Lys  Arg Asn Gly 
    1670                 1675                 1680             


Ala Leu  Leu Gly Asn His Val  Asn His Val Asn Ser  Asp Arg Arg 
    1685                 1690                 1695             


Asp Ser  Leu Gln Gln Thr Asn  Thr Thr His Arg Pro  Leu His Val 
    1700                 1705                 1710             


Gln Arg  Pro Ser Ile Pro Pro  Ala Ser Asp Thr Glu  Lys Pro Leu 
    1715                 1720                 1725             


Phe Pro  Pro Ala Gly Asn Ser  Val Cys His Asn His  His Asn His 
    1730                 1735                 1740             


Asn Ser  Ile Gly Lys Gln Val  Pro Thr Ser Thr Asn  Ala Asn Leu 
    1745                 1750                 1755             


Asn Asn  Ala Asn Met Ser Lys  Ala Ala His Gly Lys  Arg Pro Ser 
    1760                 1765                 1770             


Ile Gly  Asn Leu Glu His Val  Ser Glu Asn Gly His  His Ser Ser 
    1775                 1780                 1785             


His Lys  His Asp Arg Glu Pro  Gln Arg Arg Ser Ser  Val Lys Arg 
    1790                 1795                 1800             


Thr Arg  Tyr Tyr Glu Thr Tyr  Ile Arg Ser Asp Ser  Gly Asp Glu 
    1805                 1810                 1815             


Gln Leu  Pro Thr Ile Cys Arg  Glu Asp Pro Glu Ile  His Gly Tyr 
    1820                 1825                 1830             


Phe Arg  Asp Pro His Cys Leu  Gly Glu Gln Glu Tyr  Phe Ser Ser 
    1835                 1840                 1845             


Glu Glu  Cys Tyr Glu Asp Asp  Ser Ser Pro Thr Trp  Ser Arg Gln 
    1850                 1855                 1860             


Asn Tyr  Gly Tyr Tyr Ser Arg  Tyr Pro Gly Arg Asn  Ile Asp Ser 
    1865                 1870                 1875             


Glu Arg  Pro Arg Gly Tyr His  His Pro Gln Gly Phe  Leu Glu Asp 
    1880                 1885                 1890             


Asp Asp  Ser Pro Val Cys Tyr  Asp Ser Arg Arg Ser  Pro Arg Arg 
    1895                 1900                 1905             


Arg Leu  Leu Pro Pro Thr Pro  Ala Ser His Arg Arg  Ser Ser Phe 
    1910                 1915                 1920             


Asn Phe  Glu Cys Leu Arg Arg  Gln Ser Ser Gln Glu  Glu Val Pro 
    1925                 1930                 1935             


Ser Ser  Pro Ile Phe Pro His  Arg Thr Ala Leu Pro  Leu His Leu 
    1940                 1945                 1950             


Met Gln  Gln Gln Ile Met Ala  Val Ala Gly Leu Asp  Ser Ser Lys 
    1955                 1960                 1965             


Ala Gln  Lys Tyr Ser Pro Ser  His Ser Thr Arg Ser  Trp Ala Thr 
    1970                 1975                 1980             


Pro Pro  Ala Thr Pro Pro Tyr  Arg Asp Trp Thr Pro  Cys Tyr Thr 
    1985                 1990                 1995             


Pro Leu  Ile Gln Val Glu Gln  Ser Glu Ala Leu Asp  Gln Val Asn 
    2000                 2005                 2010             


Gly Ser  Leu Pro Ser Leu His  Arg Ser Ser Trp Tyr  Thr Asp Glu 
    2015                 2020                 2025             


Pro Asp  Ile Ser Tyr Arg Thr  Phe Thr Pro Ala Ser  Leu Thr Val 
    2030                 2035                 2040             


Pro Ser  Ser Phe Arg Asn Lys  Asn Ser Asp Lys Gln  Arg Ser Ala 
    2045                 2050                 2055             


Asp Ser  Leu Val Glu Ala Val  Leu Ile Ser Glu Gly  Leu Gly Arg 
    2060                 2065                 2070             


Tyr Ala  Arg Asp Pro Lys Phe  Val Ser Ala Thr Lys  His Glu Ile 
    2075                 2080                 2085             


Ala Asp  Ala Cys Asp Leu Thr  Ile Asp Glu Met Glu  Ser Ala Ala 
    2090                 2095                 2100             


Ser Thr  Leu Leu Asn Gly Asn  Val Arg Pro Arg Ala  Asn Gly Asp 
    2105                 2110                 2115             


Val Gly  Pro Leu Ser His Arg  Gln Asp Tyr Glu Leu  Gln Asp Phe 
    2120                 2125                 2130             


Gly Pro  Gly Tyr Ser Asp Glu  Glu Pro Asp Pro Gly  Arg Asp Glu 
    2135                 2140                 2145             


Glu Asp  Leu Ala Asp Glu Met  Ile Cys Ile Thr Thr  Leu 
    2150                 2155                 2160     


<210> 14
<211> 1966
<212> PRT
<213> Homo sapiens

<400> 14
Met Ser Glu Ser Glu Gly Gly Lys Asp Thr Thr Pro Glu Pro Ser Pro 
1               5                   10                  15      


Ala Asn Gly Ala Gly Pro Gly Pro Glu Trp Gly Leu Cys Pro Gly Pro 
            20                  25                  30          


Pro Ala Val Glu Gly Glu Ser Ser Gly Ala Ser Gly Leu Gly Thr Pro 
        35                  40                  45              


Lys Arg Arg Asn Gln His Ser Lys His Lys Thr Val Ala Val Ala Ser 
    50                  55                  60                  


Ala Gln Arg Ser Pro Arg Ala Leu Phe Cys Leu Thr Leu Ala Asn Pro 
65                  70                  75                  80  


Leu Arg Arg Ser Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Asp Ile 
                85                  90                  95      


Leu Ile Leu Leu Thr Ile Phe Ala Asn Cys Val Ala Leu Gly Val Tyr 
            100                 105                 110         


Ile Pro Phe Pro Glu Asp Asp Ser Asn Thr Ala Asn His Asn Leu Glu 
        115                 120                 125             


Gln Val Glu Tyr Val Phe Leu Val Ile Phe Thr Val Glu Thr Val Leu 
    130                 135                 140                 


Lys Ile Val Ala Tyr Gly Leu Val Leu His Pro Ser Ala Tyr Ile Arg 
145                 150                 155                 160 


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
                165                 170                 175     


Ser Val Leu Leu Glu Gln Gly Pro Gly Arg Pro Gly Asp Ala Pro His 
            180                 185                 190         


Thr Gly Gly Lys Pro Gly Gly Phe Asp Val Lys Ala Leu Arg Ala Phe 
        195                 200                 205             


Arg Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu His 
    210                 215                 220                 


Ile Val Leu Asn Ser Ile Met Lys Ala Leu Val Pro Leu Leu His Ile 
225                 230                 235                 240 


Ala Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu 
                245                 250                 255     


Glu Leu Phe Leu Gly Arg Met His Lys Thr Cys Tyr Phe Leu Gly Ser 
            260                 265                 270         


Asp Met Glu Ala Glu Glu Asp Pro Ser Pro Cys Ala Ser Ser Gly Ser 
        275                 280                 285             


Gly Arg Ala Cys Thr Leu Asn Gln Thr Glu Cys Arg Gly Arg Trp Pro 
    290                 295                 300                 


Gly Pro Asn Gly Gly Ile Thr Asn Phe Asp Asn Phe Phe Phe Ala Met 
305                 310                 315                 320 


Leu Thr Val Phe Gln Cys Val Thr Met Glu Gly Trp Thr Asp Val Leu 
                325                 330                 335     


Tyr Trp Met Gln Asp Ala Met Gly Tyr Glu Leu Pro Trp Val Tyr Phe 
            340                 345                 350         


Val Ser Leu Val Ile Phe Gly Ser Phe Phe Val Leu Asn Leu Val Leu 
        355                 360                 365             


Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys Ala 
    370                 375                 380                 


Arg Gly Asp Phe Gln Lys Gln Arg Glu Lys Gln Gln Met Glu Glu Asp 
385                 390                 395                 400 


Leu Arg Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Glu Leu Asp Met 
                405                 410                 415     


Glu Asp Pro Ser Ala Asp Asp Asn Leu Gly Pro Gln Leu Ala Glu Leu 
            420                 425                 430         


Thr Asn Arg Arg Arg Gly Arg Leu Arg Trp Phe Ser His Ser Thr Arg 
        435                 440                 445             


Ser Thr His Ser Thr Ser Ser His Ala Ser Leu Pro Ala Ser Asp Thr 
    450                 455                 460                 


Gly Ser Met Thr Glu Thr Gln Gly Asp Glu Asp Glu Glu Glu Gly Ala 
465                 470                 475                 480 


Leu Ala Ser Cys Thr Arg Cys Leu Asn Lys Ile Met Lys Thr Arg Val 
                485                 490                 495     


Cys Arg Arg Leu Arg Arg Ala Asn Arg Val Leu Arg Ala Arg Cys Arg 
            500                 505                 510         


Arg Ala Val Lys Ser Asn Ala Cys Tyr Trp Ala Val Leu Leu Leu Val 
        515                 520                 525             


Phe Leu Asn Thr Leu Thr Ile Ala Ser Glu His His Gly Gln Pro Val 
    530                 535                 540                 


Trp Leu Thr Gln Ile Gln Glu Tyr Ala Asn Lys Val Leu Leu Cys Leu 
545                 550                 555                 560 


Phe Thr Val Glu Met Leu Leu Lys Leu Tyr Gly Leu Gly Pro Ser Ala 
                565                 570                 575     


Tyr Val Ser Ser Phe Phe Asn Arg Phe Asp Cys Phe Val Val Cys Gly 
            580                 585                 590         


Gly Ile Leu Glu Thr Thr Leu Val Glu Val Gly Ala Met Gln Pro Leu 
        595                 600                 605             


Gly Ile Ser Val Leu Arg Cys Val Arg Leu Leu Arg Ile Phe Lys Val 
    610                 615                 620                 


Thr Arg His Trp Ala Ser Leu Ser Asn Leu Val Ala Ser Leu Leu Asn 
625                 630                 635                 640 


Ser Met Lys Ser Ile Ala Ser Leu Leu Leu Leu Leu Phe Leu Phe Ile 
                645                 650                 655     


Ile Ile Phe Ser Leu Leu Gly Met Gln Leu Phe Gly Gly Lys Phe Asn 
            660                 665                 670         


Phe Asp Gln Thr His Thr Lys Arg Ser Thr Phe Asp Thr Phe Pro Gln 
        675                 680                 685             


Ala Leu Leu Thr Val Phe Gln Ile Leu Thr Gly Glu Asp Trp Asn Val 
    690                 695                 700                 


Val Met Tyr Asp Gly Ile Met Ala Tyr Gly Gly Pro Phe Phe Pro Gly 
705                 710                 715                 720 


Met Leu Val Cys Ile Tyr Phe Ile Ile Leu Phe Ile Cys Gly Asn Tyr 
                725                 730                 735     


Ile Leu Leu Asn Val Phe Leu Ala Ile Ala Val Asp Asn Leu Ala Ser 
            740                 745                 750         


Gly Asp Ala Gly Thr Ala Lys Asp Lys Gly Gly Glu Lys Ser Asn Glu 
        755                 760                 765             


Lys Asp Leu Pro Gln Glu Asn Glu Gly Leu Val Pro Gly Val Glu Lys 
    770                 775                 780                 


Glu Glu Glu Glu Gly Ala Arg Arg Glu Gly Ala Asp Met Glu Glu Glu 
785                 790                 795                 800 


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Ala 
                805                 810                 815     


Gly Gly Val Glu Leu Leu Gln Glu Val Val Pro Lys Glu Lys Val Val 
            820                 825                 830         


Pro Ile Pro Glu Gly Ser Ala Phe Phe Cys Leu Ser Gln Thr Asn Pro 
        835                 840                 845             


Leu Arg Lys Gly Cys His Thr Leu Ile His His His Val Phe Thr Asn 
    850                 855                 860                 


Leu Ile Leu Val Phe Ile Ile Leu Ser Ser Val Ser Leu Ala Ala Glu 
865                 870                 875                 880 


Asp Pro Ile Arg Ala His Ser Phe Arg Asn His Ile Leu Gly Tyr Phe 
                885                 890                 895     


Asp Tyr Ala Phe Thr Ser Ile Phe Thr Val Glu Ile Leu Leu Lys Met 
            900                 905                 910         


Thr Val Phe Gly Ala Phe Leu His Arg Gly Ser Phe Cys Arg Ser Trp 
        915                 920                 925             


Phe Asn Met Leu Asp Leu Leu Val Val Ser Val Ser Leu Ile Ser Phe 
    930                 935                 940                 


Gly Ile His Ser Ser Ala Ile Ser Val Val Lys Ile Leu Arg Val Leu 
945                 950                 955                 960 


Arg Val Leu Arg Pro Leu Arg Ala Ile Asn Arg Ala Lys Gly Leu Lys 
                965                 970                 975     


His Val Val Gln Cys Val Phe Val Ala Ile Arg Thr Ile Gly Asn Ile 
            980                 985                 990         


Met Ile Val Thr Thr Leu Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val 
        995                 1000                 1005             


Gln Leu  Phe Lys Gly Lys Phe  Tyr Thr Cys Thr Asp  Glu Ala Lys 
    1010                 1015                 1020             


His Thr  Pro Gln Glu Cys Lys  Gly Ser Phe Leu Val  Tyr Pro Asp 
    1025                 1030                 1035             


Gly Asp  Val Ser Arg Pro Leu  Val Arg Glu Arg Leu  Trp Val Asn 
    1040                 1045                 1050             


Ser Asp  Phe Asn Phe Asp Asn  Val Leu Ser Ala Met  Met Ala Leu 
    1055                 1060                 1065             


Phe Thr  Val Ser Thr Phe Glu  Gly Trp Pro Ala Leu  Leu Tyr Lys 
    1070                 1075                 1080             


Ala Ile  Asp Ala Tyr Ala Glu  Asp His Gly Pro Ile  Tyr Asn Tyr 
    1085                 1090                 1095             


Arg Val  Glu Ile Ser Val Phe  Phe Ile Val Tyr Ile  Ile Ile Ile 
    1100                 1105                 1110             


Ala Phe  Phe Met Met Asn Ile  Phe Val Gly Phe Val  Ile Ile Thr 
    1115                 1120                 1125             


Phe Arg  Ala Gln Gly Glu Gln  Glu Tyr Gln Asn Cys  Glu Leu Asp 
    1130                 1135                 1140             


Lys Asn  Gln Arg Gln Cys Val  Glu Tyr Ala Leu Lys  Ala Gln Pro 
    1145                 1150                 1155             


Leu Arg  Arg Tyr Ile Pro Lys  Asn Pro His Gln Tyr  Arg Val Trp 
    1160                 1165                 1170             


Ala Thr  Val Asn Ser Ala Ala  Phe Glu Tyr Leu Met  Phe Leu Leu 
    1175                 1180                 1185             


Ile Leu  Leu Asn Thr Val Ala  Leu Ala Met Gln His  Tyr Glu Gln 
    1190                 1195                 1200             


Thr Ala  Pro Phe Asn Tyr Ala  Met Asp Ile Leu Asn  Met Val Phe 
    1205                 1210                 1215             


Thr Gly  Leu Phe Thr Ile Glu  Met Val Leu Lys Ile  Ile Ala Phe 
    1220                 1225                 1230             


Lys Pro  Lys His Tyr Phe Thr  Asp Ala Trp Asn Thr  Phe Asp Ala 
    1235                 1240                 1245             


Leu Ile  Val Val Gly Ser Ile  Val Asp Ile Ala Val  Thr Glu Val 
    1250                 1255                 1260             


Asn Asn  Gly Gly His Leu Gly  Glu Ser Ser Glu Asp  Ser Ser Arg 
    1265                 1270                 1275             


Ile Ser  Ile Thr Phe Phe Arg  Leu Phe Arg Val Met  Arg Leu Val 
    1280                 1285                 1290             


Lys Leu  Leu Ser Lys Gly Glu  Gly Ile Arg Thr Leu  Leu Trp Thr 
    1295                 1300                 1305             


Phe Ile  Lys Ser Phe Gln Ala  Leu Pro Tyr Val Ala  Leu Leu Ile 
    1310                 1315                 1320             


Ala Met  Ile Phe Phe Ile Tyr  Ala Val Ile Gly Met  Gln Met Phe 
    1325                 1330                 1335             


Gly Lys  Val Ala Leu Gln Asp  Gly Thr Gln Ile Asn  Arg Asn Asn 
    1340                 1345                 1350             


Asn Phe  Gln Thr Phe Pro Gln  Ala Val Leu Leu Leu  Phe Arg Cys 
    1355                 1360                 1365             


Ala Thr  Gly Glu Ala Trp Gln  Glu Ile Met Leu Ala  Ser Leu Pro 
    1370                 1375                 1380             


Gly Asn  Arg Cys Asp Pro Glu  Ser Asp Phe Gly Pro  Gly Glu Glu 
    1385                 1390                 1395             


Phe Thr  Cys Gly Ser Asn Phe  Ala Ile Ala Tyr Phe  Ile Ser Phe 
    1400                 1405                 1410             


Phe Met  Leu Cys Ala Phe Leu  Ile Ile Asn Leu Phe  Val Ala Val 
    1415                 1420                 1425             


Ile Met  Asp Asn Phe Asp Tyr  Leu Thr Arg Asp Trp  Ser Ile Leu 
    1430                 1435                 1440             


Gly Pro  His His Leu Asp Glu  Phe Lys Arg Ile Trp  Ser Glu Tyr 
    1445                 1450                 1455             


Asp Pro  Gly Ala Lys Gly Arg  Ile Lys His Leu Asp  Val Val Ala 
    1460                 1465                 1470             


Leu Leu  Arg Arg Ile Gln Pro  Pro Leu Gly Phe Gly  Lys Leu Cys 
    1475                 1480                 1485             


Pro His  Arg Val Ala Cys Lys  Arg Leu Val Ala Met  Asn Met Pro 
    1490                 1495                 1500             


Leu Asn  Ser Asp Gly Thr Val  Thr Phe Asn Ala Thr  Leu Phe Ala 
    1505                 1510                 1515             


Leu Val  Arg Thr Ser Leu Lys  Ile Lys Thr Glu Gly  Asn Leu Glu 
    1520                 1525                 1530             


Gln Ala  Asn Gln Glu Leu Arg  Ile Val Ile Lys Lys  Ile Trp Lys 
    1535                 1540                 1545             


Arg Met  Lys Gln Lys Leu Leu  Asp Glu Val Ile Pro  Pro Pro Asp 
    1550                 1555                 1560             


Glu Glu  Glu Val Thr Val Gly  Lys Phe Tyr Ala Thr  Phe Leu Ile 
    1565                 1570                 1575             


Gln Asp  Tyr Phe Arg Lys Phe  Arg Arg Arg Lys Glu  Lys Gly Leu 
    1580                 1585                 1590             


Leu Gly  Asn Asp Ala Ala Pro  Ser Thr Ser Ser Ala  Leu Gln Ala 
    1595                 1600                 1605             


Gly Leu  Arg Ser Leu Gln Asp  Leu Gly Pro Glu Met  Arg Gln Ala 
    1610                 1615                 1620             


Leu Thr  Cys Asp Thr Glu Glu  Glu Glu Glu Glu Gly  Gln Glu Gly 
    1625                 1630                 1635             


Val Glu  Glu Glu Asp Glu Lys  Asp Leu Glu Thr Asn  Lys Ala Thr 
    1640                 1645                 1650             


Met Val  Ser Gln Pro Ser Ala  Arg Arg Gly Ser Gly  Ile Ser Val 
    1655                 1660                 1665             


Ser Leu  Pro Val Gly Asp Arg  Leu Pro Asp Ser Leu  Ser Phe Gly 
    1670                 1675                 1680             


Pro Ser  Asp Asp Asp Arg Gly  Thr Pro Thr Ser Ser  Gln Pro Ser 
    1685                 1690                 1695             


Val Pro  Gln Ala Gly Ser Asn  Thr His Arg Arg Gly  Ser Gly Ala 
    1700                 1705                 1710             


Leu Ile  Phe Thr Ile Pro Glu  Glu Gly Asn Ser Gln  Pro Lys Gly 
    1715                 1720                 1725             


Thr Lys  Gly Gln Asn Lys Gln  Asp Glu Asp Glu Glu  Val Pro Asp 
    1730                 1735                 1740             


Arg Leu  Ser Tyr Leu Asp Glu  Gln Ala Gly Thr Pro  Pro Cys Ser 
    1745                 1750                 1755             


Val Leu  Leu Pro Pro His Arg  Ala Gln Arg Tyr Met  Asp Gly His 
    1760                 1765                 1770             


Leu Val  Pro Arg Arg Arg Leu  Leu Pro Pro Thr Pro  Ala Gly Arg 
    1775                 1780                 1785             


Lys Pro  Ser Phe Thr Ile Gln  Cys Leu Gln Arg Gln  Gly Ser Cys 
    1790                 1795                 1800             


Glu Asp  Leu Pro Ile Pro Gly  Thr Tyr His Arg Gly  Arg Asn Ser 
    1805                 1810                 1815             


Gly Pro  Asn Arg Ala Gln Gly  Ser Trp Ala Thr Pro  Pro Gln Arg 
    1820                 1825                 1830             


Gly Arg  Leu Leu Tyr Ala Pro  Leu Leu Leu Val Glu  Glu Gly Ala 
    1835                 1840                 1845             


Ala Gly  Glu Gly Tyr Leu Gly  Arg Ser Ser Gly Pro  Leu Arg Thr 
    1850                 1855                 1860             


Phe Thr  Cys Leu His Val Pro  Gly Thr His Ser Asp  Pro Ser His 
    1865                 1870                 1875             


Gly Lys  Arg Gly Ser Ala Asp  Ser Leu Val Glu Ala  Val Leu Ile 
    1880                 1885                 1890             


Ser Glu  Gly Leu Gly Leu Phe  Ala Arg Asp Pro Arg  Phe Val Ala 
    1895                 1900                 1905             


Leu Ala  Lys Gln Glu Ile Ala  Asp Ala Cys Arg Leu  Thr Leu Asp 
    1910                 1915                 1920             


Glu Met  Asp Asn Ala Ala Ser  Asp Leu Leu Ala Gln  Gly Thr Ser 
    1925                 1930                 1935             


Ser Leu  Tyr Ser Asp Glu Glu  Ser Ile Leu Ser Arg  Phe Asp Glu 
    1940                 1945                 1950             


Glu Asp  Leu Gly Asp Glu Met  Ala Cys Val His Ala  Leu 
    1955                 1960                 1965     


<210> 15
<211> 2266
<212> PRT
<213> Homo sapiens

<400> 15
Met Ala Arg Phe Gly Asp Glu Met Pro Ala Arg Tyr Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Ala Ala Ala Gly Val Val Val Gly Ser Gly Gly Gly Arg Gly 
            20                  25                  30          


Ala Gly Gly Ser Arg Gln Gly Gly Gln Pro Gly Ala Gln Arg Met Tyr 
        35                  40                  45              


Lys Gln Ser Met Ala Gln Arg Ala Arg Thr Met Ala Leu Tyr Asn Pro 
    50                  55                  60                  


Ile Pro Val Arg Gln Asn Cys Leu Thr Val Asn Arg Ser Leu Phe Leu 
65                  70                  75                  80  


Phe Ser Glu Asp Asn Val Val Arg Lys Tyr Ala Lys Lys Ile Thr Glu 
                85                  90                  95      


Trp Pro Pro Phe Glu Tyr Met Ile Leu Ala Thr Ile Ile Ala Asn Cys 
            100                 105                 110         


Ile Val Leu Ala Leu Glu Gln His Leu Pro Asp Asp Asp Lys Thr Pro 
        115                 120                 125             


Met Ser Glu Arg Leu Asp Asp Thr Glu Pro Tyr Phe Ile Gly Ile Phe 
    130                 135                 140                 


Cys Phe Glu Ala Gly Ile Lys Ile Ile Ala Leu Gly Phe Ala Phe His 
145                 150                 155                 160 


Lys Gly Ser Tyr Leu Arg Asn Gly Trp Asn Val Met Asp Phe Val Val 
                165                 170                 175     


Val Leu Thr Gly Ile Leu Ala Thr Val Gly Thr Glu Phe Asp Leu Arg 
            180                 185                 190         


Thr Leu Arg Ala Val Arg Val Leu Arg Pro Leu Lys Leu Val Ser Gly 
        195                 200                 205             


Ile Pro Ser Leu Gln Val Val Leu Lys Ser Ile Met Lys Ala Met Ile 
    210                 215                 220                 


Pro Leu Leu Gln Ile Gly Leu Leu Leu Phe Phe Ala Ile Leu Ile Phe 
225                 230                 235                 240 


Ala Ile Ile Gly Leu Glu Phe Tyr Met Gly Lys Phe His Thr Thr Cys 
                245                 250                 255     


Phe Glu Glu Gly Thr Asp Asp Ile Gln Gly Glu Ser Pro Ala Pro Cys 
            260                 265                 270         


Gly Thr Glu Glu Pro Ala Arg Thr Cys Pro Asn Gly Thr Lys Cys Gln 
        275                 280                 285             


Pro Tyr Trp Glu Gly Pro Asn Asn Gly Ile Thr Gln Phe Asp Asn Ile 
    290                 295                 300                 


Leu Phe Ala Val Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp 
305                 310                 315                 320 


Thr Asp Leu Leu Tyr Asn Ser Asn Asp Ala Ser Gly Asn Thr Trp Asn 
                325                 330                 335     


Trp Leu Tyr Phe Ile Pro Leu Ile Ile Ile Gly Ser Phe Phe Met Leu 
            340                 345                 350         


Asn Leu Val Leu Gly Val Leu Ser Gly Glu Phe Ala Lys Glu Arg Glu 
        355                 360                 365             


Arg Val Glu Asn Arg Arg Ala Phe Leu Lys Leu Arg Arg Gln Gln Gln 
    370                 375                 380                 


Ile Glu Arg Glu Leu Asn Gly Tyr Met Glu Trp Ile Ser Lys Ala Glu 
385                 390                 395                 400 


Glu Val Ile Leu Ala Glu Asp Glu Thr Asp Gly Glu Gln Arg His Pro 
                405                 410                 415     


Phe Asp Gly Ala Leu Arg Arg Thr Thr Ile Lys Lys Ser Lys Thr Asp 
            420                 425                 430         


Leu Leu Asn Pro Glu Glu Ala Glu Asp Gln Leu Ala Asp Ile Ala Ser 
        435                 440                 445             


Val Gly Ser Pro Phe Ala Arg Ala Ser Ile Lys Ser Ala Lys Leu Glu 
    450                 455                 460                 


Asn Ser Thr Phe Phe His Lys Lys Glu Arg Arg Met Arg Phe Tyr Ile 
465                 470                 475                 480 


Arg Arg Met Val Lys Thr Gln Ala Phe Tyr Trp Thr Val Leu Ser Leu 
                485                 490                 495     


Val Ala Leu Asn Thr Leu Cys Val Ala Ile Val His Tyr Asn Gln Pro 
            500                 505                 510         


Glu Trp Leu Ser Asp Phe Leu Tyr Tyr Ala Glu Phe Ile Phe Leu Gly 
        515                 520                 525             


Leu Phe Met Ser Glu Met Phe Ile Lys Met Tyr Gly Leu Gly Thr Arg 
    530                 535                 540                 


Pro Tyr Phe His Ser Ser Phe Asn Cys Phe Asp Cys Gly Val Ile Ile 
545                 550                 555                 560 


Gly Ser Ile Phe Glu Val Ile Trp Ala Val Ile Lys Pro Gly Thr Ser 
                565                 570                 575     


Phe Gly Ile Ser Val Leu Arg Ala Leu Arg Leu Leu Arg Ile Phe Lys 
            580                 585                 590         


Val Thr Lys Tyr Trp Ala Ser Leu Arg Asn Leu Val Val Ser Leu Leu 
        595                 600                 605             


Asn Ser Met Lys Ser Ile Ile Ser Leu Leu Phe Leu Leu Phe Leu Phe 
    610                 615                 620                 


Ile Val Val Phe Ala Leu Leu Gly Met Gln Leu Phe Gly Gly Gln Phe 
625                 630                 635                 640 


Asn Phe Asp Glu Gly Thr Pro Pro Thr Asn Phe Asp Thr Phe Pro Ala 
                645                 650                 655     


Ala Ile Met Thr Val Phe Gln Ile Leu Thr Gly Glu Asp Trp Asn Glu 
            660                 665                 670         


Val Met Tyr Asp Gly Ile Lys Ser Gln Gly Gly Val Gln Gly Gly Met 
        675                 680                 685             


Val Phe Ser Ile Tyr Phe Ile Val Leu Thr Leu Phe Gly Asn Tyr Thr 
    690                 695                 700                 


Leu Leu Asn Val Phe Leu Ala Ile Ala Val Asp Asn Leu Ala Asn Ala 
705                 710                 715                 720 


Gln Glu Leu Thr Lys Val Glu Ala Asp Glu Gln Glu Glu Glu Glu Ala 
                725                 730                 735     


Ala Asn Gln Lys Leu Ala Leu Gln Lys Ala Lys Glu Val Ala Glu Val 
            740                 745                 750         


Ser Pro Leu Ser Ala Ala Asn Met Ser Ile Ala Val Lys Glu Gln Gln 
        755                 760                 765             


Lys Asn Gln Lys Pro Ala Lys Ser Val Trp Glu Gln Arg Thr Ser Glu 
    770                 775                 780                 


Met Arg Lys Gln Asn Leu Leu Ala Ser Arg Glu Ala Leu Tyr Asn Glu 
785                 790                 795                 800 


Met Asp Pro Asp Glu Arg Trp Lys Ala Ala Tyr Thr Arg His Leu Arg 
                805                 810                 815     


Pro Asp Met Lys Thr His Leu Asp Arg Pro Leu Val Val Asp Pro Gln 
            820                 825                 830         


Glu Asn Arg Asn Asn Asn Thr Asn Lys Ser Arg Ala Ala Glu Pro Thr 
        835                 840                 845             


Val Asp Gln Arg Leu Gly Gln Gln Arg Ala Glu Asp Phe Leu Arg Lys 
    850                 855                 860                 


Gln Ala Arg Tyr His Asp Arg Ala Arg Asp Pro Ser Gly Ser Ala Gly 
865                 870                 875                 880 


Leu Asp Ala Arg Arg Pro Trp Ala Gly Ser Gln Glu Ala Glu Leu Ser 
                885                 890                 895     


Arg Glu Gly Pro Tyr Gly Arg Glu Ser Asp His His Ala Arg Glu Gly 
            900                 905                 910         


Ser Leu Glu Gln Pro Gly Phe Trp Glu Gly Glu Ala Glu Arg Gly Lys 
        915                 920                 925             


Ala Gly Asp Pro His Arg Arg His Val His Arg Gln Gly Gly Ser Arg 
    930                 935                 940                 


Glu Ser Arg Ser Gly Ser Pro Arg Thr Gly Ala Asp Gly Glu His Arg 
945                 950                 955                 960 


Arg His Arg Ala His Arg Arg Pro Gly Glu Glu Gly Pro Glu Asp Lys 
                965                 970                 975     


Ala Glu Arg Arg Ala Arg His Arg Glu Gly Ser Arg Pro Ala Arg Gly 
            980                 985                 990         


Gly Glu Gly Glu Gly Glu Gly Pro  Asp Gly Gly Glu Arg  Arg Arg Arg 
        995                 1000                 1005             


His Arg  His Gly Ala Pro Ala  Thr Tyr Glu Gly Asp  Ala Arg Arg 
    1010                 1015                 1020             


Glu Asp  Lys Glu Arg Arg His  Arg Arg Arg Lys Glu  Asn Gln Gly 
    1025                 1030                 1035             


Ser Gly  Val Pro Val Ser Gly  Pro Asn Leu Ser Thr  Thr Arg Pro 
    1040                 1045                 1050             


Ile Gln  Gln Asp Leu Gly Arg  Gln Asp Pro Pro Leu  Ala Glu Asp 
    1055                 1060                 1065             


Ile Asp  Asn Met Lys Asn Asn  Lys Leu Ala Thr Ala  Glu Ser Ala 
    1070                 1075                 1080             


Ala Pro  His Gly Ser Leu Gly  His Ala Gly Leu Pro  Gln Ser Pro 
    1085                 1090                 1095             


Ala Lys  Met Gly Asn Ser Thr  Asp Pro Gly Pro Met  Leu Ala Ile 
    1100                 1105                 1110             


Pro Ala  Met Ala Thr Asn Pro  Gln Asn Ala Ala Ser  Arg Arg Thr 
    1115                 1120                 1125             


Pro Asn  Asn Pro Gly Asn Pro  Ser Asn Pro Gly Pro  Pro Lys Thr 
    1130                 1135                 1140             


Pro Glu  Asn Ser Leu Ile Val  Thr Asn Pro Ser Gly  Thr Gln Thr 
    1145                 1150                 1155             


Asn Ser  Ala Lys Thr Ala Arg  Lys Pro Asp His Thr  Thr Val Asp 
    1160                 1165                 1170             


Ile Pro  Pro Ala Cys Pro Pro  Pro Leu Asn His Thr  Val Val Gln 
    1175                 1180                 1185             


Val Asn  Lys Asn Ala Asn Pro  Asp Pro Leu Pro Lys  Lys Glu Glu 
    1190                 1195                 1200             


Glu Lys  Lys Glu Glu Glu Glu  Asp Asp Arg Gly Glu  Asp Gly Pro 
    1205                 1210                 1215             


Lys Pro  Met Pro Pro Tyr Ser  Ser Met Phe Ile Leu  Ser Thr Thr 
    1220                 1225                 1230             


Asn Pro  Leu Arg Arg Leu Cys  His Tyr Ile Leu Asn  Leu Arg Tyr 
    1235                 1240                 1245             


Phe Glu  Met Cys Ile Leu Met  Val Ile Ala Met Ser  Ser Ile Ala 
    1250                 1255                 1260             


Leu Ala  Ala Glu Asp Pro Val  Gln Pro Asn Ala Pro  Arg Asn Asn 
    1265                 1270                 1275             


Val Leu  Arg Tyr Phe Asp Tyr  Val Phe Thr Gly Val  Phe Thr Phe 
    1280                 1285                 1290             


Glu Met  Val Ile Lys Met Ile  Asp Leu Gly Leu Val  Leu His Gln 
    1295                 1300                 1305             


Gly Ala  Tyr Phe Arg Asp Leu  Trp Asn Ile Leu Asp  Phe Ile Val 
    1310                 1315                 1320             


Val Ser  Gly Ala Leu Val Ala  Phe Ala Phe Thr Gly  Asn Ser Lys 
    1325                 1330                 1335             


Gly Lys  Asp Ile Asn Thr Ile  Lys Ser Leu Arg Val  Leu Arg Val 
    1340                 1345                 1350             


Leu Arg  Pro Leu Lys Thr Ile  Lys Arg Leu Pro Lys  Leu Lys Ala 
    1355                 1360                 1365             


Val Phe  Asp Cys Val Val Asn  Ser Leu Lys Asn Val  Phe Asn Ile 
    1370                 1375                 1380             


Leu Ile  Val Tyr Met Leu Phe  Met Phe Ile Phe Ala  Val Val Ala 
    1385                 1390                 1395             


Val Gln  Leu Phe Lys Gly Lys  Phe Phe His Cys Thr  Asp Glu Ser 
    1400                 1405                 1410             


Lys Glu  Phe Glu Lys Asp Cys  Arg Gly Lys Tyr Leu  Leu Tyr Glu 
    1415                 1420                 1425             


Lys Asn  Glu Val Lys Ala Arg  Asp Arg Glu Trp Lys  Lys Tyr Glu 
    1430                 1435                 1440             


Phe His  Tyr Asp Asn Val Leu  Trp Ala Leu Leu Thr  Leu Phe Thr 
    1445                 1450                 1455             


Val Ser  Thr Gly Glu Gly Trp  Pro Gln Val Leu Lys  His Ser Val 
    1460                 1465                 1470             


Asp Ala  Thr Phe Glu Asn Gln  Gly Pro Ser Pro Gly  Tyr Arg Met 
    1475                 1480                 1485             


Glu Met  Ser Ile Phe Tyr Val  Val Tyr Phe Val Val  Phe Pro Phe 
    1490                 1495                 1500             


Phe Phe  Val Asn Ile Phe Val  Ala Leu Ile Ile Ile  Thr Phe Gln 
    1505                 1510                 1515             


Glu Gln  Gly Asp Lys Met Met  Glu Glu Tyr Ser Leu  Glu Lys Asn 
    1520                 1525                 1530             


Glu Arg  Ala Cys Ile Asp Phe  Ala Ile Ser Ala Lys  Pro Leu Thr 
    1535                 1540                 1545             


Arg His  Met Pro Gln Asn Lys  Gln Ser Phe Gln Tyr  Arg Met Trp 
    1550                 1555                 1560             


Gln Phe  Val Val Ser Pro Pro  Phe Glu Tyr Thr Ile  Met Ala Met 
    1565                 1570                 1575             


Ile Ala  Leu Asn Thr Ile Val  Leu Met Met Lys Phe  Tyr Gly Ala 
    1580                 1585                 1590             


Ser Val  Ala Tyr Glu Asn Ala  Leu Arg Val Phe Asn  Ile Val Phe 
    1595                 1600                 1605             


Thr Ser  Leu Phe Ser Leu Glu  Cys Val Leu Lys Val  Met Ala Phe 
    1610                 1615                 1620             


Gly Ile  Leu Asn Tyr Phe Arg  Asp Ala Trp Asn Ile  Phe Asp Phe 
    1625                 1630                 1635             


Val Thr  Val Leu Gly Ser Ile  Thr Asp Ile Leu Val  Thr Glu Phe 
    1640                 1645                 1650             


Gly Asn  Pro Asn Asn Phe Ile  Asn Leu Ser Phe Leu  Arg Leu Phe 
    1655                 1660                 1665             


Arg Ala  Ala Arg Leu Ile Lys  Leu Leu Arg Gln Gly  Tyr Thr Ile 
    1670                 1675                 1680             


Arg Ile  Leu Leu Trp Thr Phe  Val Gln Ser Phe Lys  Ala Leu Pro 
    1685                 1690                 1695             


Tyr Val  Cys Leu Leu Ile Ala  Met Leu Phe Phe Ile  Tyr Ala Ile 
    1700                 1705                 1710             


Ile Gly  Met Gln Val Phe Gly  Asn Ile Gly Ile Asp  Val Glu Asp 
    1715                 1720                 1725             


Glu Asp  Ser Asp Glu Asp Glu  Phe Gln Ile Thr Glu  His Asn Asn 
    1730                 1735                 1740             


Phe Arg  Thr Phe Phe Gln Ala  Leu Met Leu Leu Phe  Arg Ser Ala 
    1745                 1750                 1755             


Thr Gly  Glu Ala Trp His Asn  Ile Met Leu Ser Cys  Leu Ser Gly 
    1760                 1765                 1770             


Lys Pro  Cys Asp Lys Asn Ser  Gly Ile Leu Thr Arg  Glu Cys Gly 
    1775                 1780                 1785             


Asn Glu  Phe Ala Tyr Phe Tyr  Phe Val Ser Phe Ile  Phe Leu Cys 
    1790                 1795                 1800             


Ser Phe  Leu Met Leu Asn Leu  Phe Val Ala Val Ile  Met Asp Asn 
    1805                 1810                 1815             


Phe Glu  Tyr Leu Thr Arg Asp  Ser Ser Ile Leu Gly  Pro His His 
    1820                 1825                 1830             


Leu Asp  Glu Tyr Val Arg Val  Trp Ala Glu Tyr Asp  Pro Ala Ala 
    1835                 1840                 1845             


Trp Gly  Arg Met Pro Tyr Leu  Asp Met Tyr Gln Met  Leu Arg His 
    1850                 1855                 1860             


Met Ser  Pro Pro Leu Gly Leu  Gly Lys Lys Cys Pro  Ala Arg Val 
    1865                 1870                 1875             


Ala Tyr  Lys Arg Leu Leu Arg  Met Asp Leu Pro Val  Ala Asp Asp 
    1880                 1885                 1890             


Asn Thr  Val His Phe Asn Ser  Thr Leu Met Ala Leu  Ile Arg Thr 
    1895                 1900                 1905             


Ala Leu  Asp Ile Lys Ile Ala  Lys Gly Gly Ala Asp  Lys Gln Gln 
    1910                 1915                 1920             


Met Asp  Ala Glu Leu Arg Lys  Glu Met Met Ala Ile  Trp Pro Asn 
    1925                 1930                 1935             


Leu Ser  Gln Lys Thr Leu Asp  Leu Leu Val Thr Pro  His Lys Ser 
    1940                 1945                 1950             


Thr Asp  Leu Thr Val Gly Lys  Ile Tyr Ala Ala Met  Met Ile Met 
    1955                 1960                 1965             


Glu Tyr  Tyr Arg Gln Ser Lys  Ala Lys Lys Leu Gln  Ala Met Arg 
    1970                 1975                 1980             


Glu Glu  Gln Asp Arg Thr Pro  Leu Met Phe Gln Arg  Met Glu Pro 
    1985                 1990                 1995             


Pro Ser  Pro Thr Gln Glu Gly  Gly Pro Gly Gln Asn  Ala Leu Pro 
    2000                 2005                 2010             


Ser Thr  Gln Leu Asp Pro Gly  Gly Ala Leu Met Ala  His Glu Ser 
    2015                 2020                 2025             


Gly Leu  Lys Glu Ser Pro Ser  Trp Val Thr Gln Arg  Ala Gln Glu 
    2030                 2035                 2040             


Met Phe  Gln Lys Thr Gly Thr  Trp Ser Pro Glu Gln  Gly Pro Pro 
    2045                 2050                 2055             


Thr Asp  Met Pro Asn Ser Gln  Pro Asn Ser Gln Ser  Val Glu Met 
    2060                 2065                 2070             


Arg Glu  Met Gly Arg Asp Gly  Tyr Ser Asp Ser Glu  His Tyr Leu 
    2075                 2080                 2085             


Pro Met  Glu Gly Gln Gly Arg  Ala Ala Ser Met Pro  Arg Leu Pro 
    2090                 2095                 2100             


Ala Glu  Asn Gln Arg Arg Arg  Gly Arg Pro Arg Gly  Asn Asn Leu 
    2105                 2110                 2115             


Ser Thr  Ile Ser Asp Thr Ser  Pro Met Lys Arg Ser  Ala Ser Val 
    2120                 2125                 2130             


Leu Gly  Pro Lys Ala Arg Arg  Leu Asp Asp Tyr Ser  Leu Glu Arg 
    2135                 2140                 2145             


Val Pro  Pro Glu Glu Asn Gln  Arg His His Gln Arg  Arg Arg Asp 
    2150                 2155                 2160             


Arg Ser  His Arg Ala Ser Glu  Arg Ser Leu Gly Arg  Tyr Thr Asp 
    2165                 2170                 2175             


Val Asp  Thr Gly Leu Gly Thr  Asp Leu Ser Met Thr  Thr Gln Ser 
    2180                 2185                 2190             


Gly Asp  Leu Pro Ser Lys Glu  Arg Asp Gln Glu Arg  Gly Arg Pro 
    2195                 2200                 2205             


Lys Asp  Arg Lys His Arg Gln  His His His His His  His His His 
    2210                 2215                 2220             


His His  Pro Pro Pro Pro Asp  Lys Asp Arg Tyr Ala  Gln Glu Arg 
    2225                 2230                 2235             


Pro Asp  His Gly Arg Ala Arg  Ala Arg Asp Gln Arg  Trp Ser Arg 
    2240                 2245                 2250             


Ser Pro  Ser Glu Gly Arg Glu  His Met Ala His Arg  Gln 
    2255                 2260                 2265     


<210> 16
<211> 2339
<212> PRT
<213> Homo sapiens

<400> 16
Met Val Arg Phe Gly Asp Glu Leu Gly Gly Arg Tyr Gly Gly Pro Gly 
1               5                   10                  15      


Gly Gly Glu Arg Ala Arg Gly Gly Gly Ala Gly Gly Ala Gly Gly Pro 
            20                  25                  30          


Gly Pro Gly Gly Leu Gln Pro Gly Gln Arg Val Leu Tyr Lys Gln Ser 
        35                  40                  45              


Ile Ala Gln Arg Ala Arg Thr Met Ala Leu Tyr Asn Pro Ile Pro Val 
    50                  55                  60                  


Lys Gln Asn Cys Phe Thr Val Asn Arg Ser Leu Phe Val Phe Ser Glu 
65                  70                  75                  80  


Asp Asn Val Val Arg Lys Tyr Ala Lys Arg Ile Thr Glu Trp Pro Pro 
                85                  90                  95      


Phe Glu Tyr Met Ile Leu Ala Thr Ile Ile Ala Asn Cys Ile Val Leu 
            100                 105                 110         


Ala Leu Glu Gln His Leu Pro Asp Gly Asp Lys Thr Pro Met Ser Glu 
        115                 120                 125             


Arg Leu Asp Asp Thr Glu Pro Tyr Phe Ile Gly Ile Phe Cys Phe Glu 
    130                 135                 140                 


Ala Gly Ile Lys Ile Ile Ala Leu Gly Phe Val Phe His Lys Gly Ser 
145                 150                 155                 160 


Tyr Leu Arg Asn Gly Trp Asn Val Met Asp Phe Val Val Val Leu Thr 
                165                 170                 175     


Gly Ile Leu Ala Thr Ala Gly Thr Asp Phe Asp Leu Arg Thr Leu Arg 
            180                 185                 190         


Ala Val Arg Val Leu Arg Pro Leu Lys Leu Val Ser Gly Ile Pro Ser 
        195                 200                 205             


Leu Gln Val Val Leu Lys Ser Ile Met Lys Ala Met Val Pro Leu Leu 
    210                 215                 220                 


Gln Ile Gly Leu Leu Leu Phe Phe Ala Ile Leu Met Phe Ala Ile Ile 
225                 230                 235                 240 


Gly Leu Glu Phe Tyr Met Gly Lys Phe His Lys Ala Cys Phe Pro Asn 
                245                 250                 255     


Ser Thr Asp Ala Glu Pro Val Gly Asp Phe Pro Cys Gly Lys Glu Ala 
            260                 265                 270         


Pro Ala Arg Leu Cys Glu Gly Asp Thr Glu Cys Arg Glu Tyr Trp Pro 
        275                 280                 285             


Gly Pro Asn Phe Gly Ile Thr Asn Phe Asp Asn Ile Leu Phe Ala Ile 
    290                 295                 300                 


Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp Ile Leu 
305                 310                 315                 320 


Tyr Asn Thr Asn Asp Ala Ala Gly Asn Thr Trp Asn Trp Leu Tyr Phe 
                325                 330                 335     


Ile Pro Leu Ile Ile Ile Gly Ser Phe Phe Met Leu Asn Leu Val Leu 
            340                 345                 350         


Gly Val Leu Ser Gly Glu Phe Ala Lys Glu Arg Glu Arg Val Glu Asn 
        355                 360                 365             


Arg Arg Ala Phe Leu Lys Leu Arg Arg Gln Gln Gln Ile Glu Arg Glu 
    370                 375                 380                 


Leu Asn Gly Tyr Leu Glu Trp Ile Phe Lys Ala Glu Glu Val Met Leu 
385                 390                 395                 400 


Ala Glu Glu Asp Arg Asn Ala Glu Glu Lys Ser Pro Leu Asp Val Leu 
                405                 410                 415     


Lys Arg Ala Ala Thr Lys Lys Ser Arg Asn Asp Leu Ile His Ala Glu 
            420                 425                 430         


Glu Gly Glu Asp Arg Phe Ala Asp Leu Cys Ala Val Gly Ser Pro Phe 
        435                 440                 445             


Ala Arg Ala Ser Leu Lys Ser Gly Lys Thr Glu Ser Ser Ser Tyr Phe 
    450                 455                 460                 


Arg Arg Lys Glu Lys Met Phe Arg Phe Phe Ile Arg Arg Met Val Lys 
465                 470                 475                 480 


Ala Gln Ser Phe Tyr Trp Val Val Leu Cys Val Val Ala Leu Asn Thr 
                485                 490                 495     


Leu Cys Val Ala Met Val His Tyr Asn Gln Pro Arg Arg Leu Thr Thr 
            500                 505                 510         


Thr Leu Tyr Phe Ala Glu Phe Val Phe Leu Gly Leu Phe Leu Thr Glu 
        515                 520                 525             


Met Ser Leu Lys Met Tyr Gly Leu Gly Pro Arg Ser Tyr Phe Arg Ser 
    530                 535                 540                 


Ser Phe Asn Cys Phe Asp Phe Gly Val Ile Val Gly Ser Val Phe Glu 
545                 550                 555                 560 


Val Val Trp Ala Ala Ile Lys Pro Gly Ser Ser Phe Gly Ile Ser Val 
                565                 570                 575     


Leu Arg Ala Leu Arg Leu Leu Arg Ile Phe Lys Val Thr Lys Tyr Trp 
            580                 585                 590         


Ser Ser Leu Arg Asn Leu Val Val Ser Leu Leu Asn Ser Met Lys Ser 
        595                 600                 605             


Ile Ile Ser Leu Leu Phe Leu Leu Phe Leu Phe Ile Val Val Phe Ala 
    610                 615                 620                 


Leu Leu Gly Met Gln Leu Phe Gly Gly Gln Phe Asn Phe Gln Asp Glu 
625                 630                 635                 640 


Thr Pro Thr Thr Asn Phe Asp Thr Phe Pro Ala Ala Ile Leu Thr Val 
                645                 650                 655     


Phe Gln Ile Leu Thr Gly Glu Asp Trp Asn Ala Val Met Tyr His Gly 
            660                 665                 670         


Ile Glu Ser Gln Gly Gly Val Ser Lys Gly Met Phe Ser Ser Phe Tyr 
        675                 680                 685             


Phe Ile Val Leu Thr Leu Phe Gly Asn Tyr Thr Leu Leu Asn Val Phe 
    690                 695                 700                 


Leu Ala Ile Ala Val Asp Asn Leu Ala Asn Ala Gln Glu Leu Thr Lys 
705                 710                 715                 720 


Asp Glu Glu Glu Met Glu Glu Ala Ala Asn Gln Lys Leu Ala Leu Gln 
                725                 730                 735     


Lys Ala Lys Glu Val Ala Glu Val Ser Pro Met Ser Ala Ala Asn Ile 
            740                 745                 750         


Ser Ile Ala Ala Arg Gln Gln Asn Ser Ala Lys Ala Arg Ser Val Trp 
        755                 760                 765             


Glu Gln Arg Ala Ser Gln Leu Arg Leu Gln Asn Leu Arg Ala Ser Cys 
    770                 775                 780                 


Glu Ala Leu Tyr Ser Glu Met Asp Pro Glu Glu Arg Leu Arg Phe Ala 
785                 790                 795                 800 


Thr Thr Arg His Leu Arg Pro Asp Met Lys Thr His Leu Asp Arg Pro 
                805                 810                 815     


Leu Val Val Glu Leu Gly Arg Asp Gly Ala Arg Gly Pro Val Gly Gly 
            820                 825                 830         


Lys Ala Arg Pro Glu Ala Ala Glu Ala Pro Glu Gly Val Asp Pro Pro 
        835                 840                 845             


Arg Arg His His Arg His Arg Asp Lys Asp Lys Thr Pro Ala Ala Gly 
    850                 855                 860                 


Asp Gln Asp Arg Ala Glu Ala Pro Lys Ala Glu Ser Gly Glu Pro Gly 
865                 870                 875                 880 


Ala Arg Glu Glu Arg Pro Arg Pro His Arg Ser His Ser Lys Glu Ala 
                885                 890                 895     


Ala Gly Pro Pro Glu Ala Arg Ser Glu Arg Gly Arg Gly Pro Gly Pro 
            900                 905                 910         


Glu Gly Gly Arg Arg His His Arg Arg Gly Ser Pro Glu Glu Ala Ala 
        915                 920                 925             


Glu Arg Glu Pro Arg Arg His Arg Ala His Arg His Gln Asp Pro Ser 
    930                 935                 940                 


Lys Glu Cys Ala Gly Ala Lys Gly Glu Arg Arg Ala Arg His Arg Gly 
945                 950                 955                 960 


Gly Pro Arg Ala Gly Pro Arg Glu Ala Glu Ser Gly Glu Glu Pro Ala 
                965                 970                 975     


Arg Arg His Arg Ala Arg His Lys Ala Gln Pro Ala His Glu Ala Val 
            980                 985                 990         


Glu Lys Glu Thr Thr Glu Lys Glu  Ala Thr Glu Lys Glu  Ala Glu Ile 
        995                 1000                 1005             


Val Glu  Ala Asp Lys Glu Lys  Glu Leu Arg Asn His  Gln Pro Arg 
    1010                 1015                 1020             


Glu Pro  His Cys Asp Leu Glu  Thr Ser Gly Thr Val  Thr Val Gly 
    1025                 1030                 1035             


Pro Met  His Thr Leu Pro Ser  Thr Cys Leu Gln Lys  Val Glu Glu 
    1040                 1045                 1050             


Gln Pro  Glu Asp Ala Asp Asn  Gln Arg Asn Val Thr  Arg Met Gly 
    1055                 1060                 1065             


Ser Gln  Pro Pro Asp Pro Asn  Thr Ile Val His Ile  Pro Val Met 
    1070                 1075                 1080             


Leu Thr  Gly Pro Leu Gly Glu  Ala Thr Val Val Pro  Ser Gly Asn 
    1085                 1090                 1095             


Val Asp  Leu Glu Ser Gln Ala  Glu Gly Lys Lys Glu  Val Glu Ala 
    1100                 1105                 1110             


Asp Asp  Val Met Arg Ser Gly  Pro Arg Pro Ile Val  Pro Tyr Ser 
    1115                 1120                 1125             


Ser Met  Phe Cys Leu Ser Pro  Thr Asn Leu Leu Arg  Arg Phe Cys 
    1130                 1135                 1140             


His Tyr  Ile Val Thr Met Arg  Tyr Phe Glu Val Val  Ile Leu Val 
    1145                 1150                 1155             


Val Ile  Ala Leu Ser Ser Ile  Ala Leu Ala Ala Glu  Asp Pro Val 
    1160                 1165                 1170             


Arg Thr  Asp Ser Pro Arg Asn  Asn Ala Leu Lys Tyr  Leu Asp Tyr 
    1175                 1180                 1185             


Ile Phe  Thr Gly Val Phe Thr  Phe Glu Met Val Ile  Lys Met Ile 
    1190                 1195                 1200             


Asp Leu  Gly Leu Leu Leu His  Pro Gly Ala Tyr Phe  Arg Asp Leu 
    1205                 1210                 1215             


Trp Asn  Ile Leu Asp Phe Ile  Val Val Ser Gly Ala  Leu Val Ala 
    1220                 1225                 1230             


Phe Ala  Phe Ser Gly Ser Lys  Gly Lys Asp Ile Asn  Thr Ile Lys 
    1235                 1240                 1245             


Ser Leu  Arg Val Leu Arg Val  Leu Arg Pro Leu Lys  Thr Ile Lys 
    1250                 1255                 1260             


Arg Leu  Pro Lys Leu Lys Ala  Val Phe Asp Cys Val  Val Asn Ser 
    1265                 1270                 1275             


Leu Lys  Asn Val Leu Asn Ile  Leu Ile Val Tyr Met  Leu Phe Met 
    1280                 1285                 1290             


Phe Ile  Phe Ala Val Ile Ala  Val Gln Leu Phe Lys  Gly Lys Phe 
    1295                 1300                 1305             


Phe Tyr  Cys Thr Asp Glu Ser  Lys Glu Leu Glu Arg  Asp Cys Arg 
    1310                 1315                 1320             


Gly Gln  Tyr Leu Asp Tyr Glu  Lys Glu Glu Val Glu  Ala Gln Pro 
    1325                 1330                 1335             


Arg Gln  Trp Lys Lys Tyr Asp  Phe His Tyr Asp Asn  Val Leu Trp 
    1340                 1345                 1350             


Ala Leu  Leu Thr Leu Phe Thr  Val Ser Thr Gly Glu  Gly Trp Pro 
    1355                 1360                 1365             


Met Val  Leu Lys His Ser Val  Asp Ala Thr Tyr Glu  Glu Gln Gly 
    1370                 1375                 1380             


Pro Ser  Pro Gly Tyr Arg Met  Glu Leu Ser Ile Phe  Tyr Val Val 
    1385                 1390                 1395             


Tyr Phe  Val Val Phe Pro Phe  Phe Phe Val Asn Ile  Phe Val Ala 
    1400                 1405                 1410             


Leu Ile  Ile Ile Thr Phe Gln  Glu Gln Gly Asp Lys  Val Met Ser 
    1415                 1420                 1425             


Glu Cys  Ser Leu Glu Lys Asn  Glu Arg Ala Cys Ile  Asp Phe Ala 
    1430                 1435                 1440             


Ile Ser  Ala Lys Pro Leu Thr  Arg Tyr Met Pro Gln  Asn Arg Gln 
    1445                 1450                 1455             


Ser Phe  Gln Tyr Lys Thr Trp  Thr Phe Val Val Ser  Pro Pro Phe 
    1460                 1465                 1470             


Glu Tyr  Phe Ile Met Ala Met  Ile Ala Leu Asn Thr  Val Val Leu 
    1475                 1480                 1485             


Met Met  Lys Phe Tyr Asp Ala  Pro Tyr Glu Tyr Glu  Leu Met Leu 
    1490                 1495                 1500             


Lys Cys  Leu Asn Ile Val Phe  Thr Ser Met Phe Ser  Met Glu Cys 
    1505                 1510                 1515             


Val Leu  Lys Ile Ile Ala Phe  Gly Val Leu Asn Tyr  Phe Arg Asp 
    1520                 1525                 1530             


Ala Trp  Asn Val Phe Asp Phe  Val Thr Val Leu Gly  Ser Ile Thr 
    1535                 1540                 1545             


Asp Ile  Leu Val Thr Glu Ile  Ala Glu Thr Asn Asn  Phe Ile Asn 
    1550                 1555                 1560             


Leu Ser  Phe Leu Arg Leu Phe  Arg Ala Ala Arg Leu  Ile Lys Leu 
    1565                 1570                 1575             


Leu Arg  Gln Gly Tyr Thr Ile  Arg Ile Leu Leu Trp  Thr Phe Val 
    1580                 1585                 1590             


Gln Ser  Phe Lys Ala Leu Pro  Tyr Val Cys Leu Leu  Ile Ala Met 
    1595                 1600                 1605             


Leu Phe  Phe Ile Tyr Ala Ile  Ile Gly Met Gln Val  Phe Gly Asn 
    1610                 1615                 1620             


Ile Ala  Leu Asp Asp Asp Thr  Ser Ile Asn Arg His  Asn Asn Phe 
    1625                 1630                 1635             


Arg Thr  Phe Leu Gln Ala Leu  Met Leu Leu Phe Arg  Ser Ala Thr 
    1640                 1645                 1650             


Gly Glu  Ala Trp His Glu Ile  Met Leu Ser Cys Leu  Ser Asn Gln 
    1655                 1660                 1665             


Ala Cys  Asp Glu Gln Ala Asn  Ala Thr Glu Cys Gly  Ser Asp Phe 
    1670                 1675                 1680             


Ala Tyr  Phe Tyr Phe Val Ser  Phe Ile Phe Leu Cys  Ser Phe Leu 
    1685                 1690                 1695             


Met Leu  Asn Leu Phe Val Ala  Val Ile Met Asp Asn  Phe Glu Tyr 
    1700                 1705                 1710             


Leu Thr  Arg Asp Ser Ser Ile  Leu Gly Pro His His  Leu Asp Glu 
    1715                 1720                 1725             


Phe Ile  Arg Val Trp Ala Glu  Tyr Asp Pro Ala Ala  Cys Gly Arg 
    1730                 1735                 1740             


Ile Ser  Tyr Asn Asp Met Phe  Glu Met Leu Lys His  Met Ser Pro 
    1745                 1750                 1755             


Pro Leu  Gly Leu Gly Lys Lys  Cys Pro Ala Arg Val  Ala Tyr Lys 
    1760                 1765                 1770             


Arg Leu  Val Arg Met Asn Met  Pro Ile Ser Asn Glu  Asp Met Thr 
    1775                 1780                 1785             


Val His  Phe Thr Ser Thr Leu  Met Ala Leu Ile Arg  Thr Ala Leu 
    1790                 1795                 1800             


Glu Ile  Lys Leu Ala Pro Ala  Gly Thr Lys Gln His  Gln Cys Asp 
    1805                 1810                 1815             


Ala Glu  Leu Arg Lys Glu Ile  Ser Val Val Trp Ala  Asn Leu Pro 
    1820                 1825                 1830             


Gln Lys  Thr Leu Asp Leu Leu  Val Pro Pro His Lys  Pro Asp Glu 
    1835                 1840                 1845             


Met Thr  Val Gly Lys Val Tyr  Ala Ala Leu Met Ile  Phe Asp Phe 
    1850                 1855                 1860             


Tyr Lys  Gln Asn Lys Thr Thr  Arg Asp Gln Met Gln  Gln Ala Pro 
    1865                 1870                 1875             


Gly Gly  Leu Ser Gln Met Gly  Pro Val Ser Leu Phe  His Pro Leu 
    1880                 1885                 1890             


Lys Ala  Thr Leu Glu Gln Thr  Gln Pro Ala Val Leu  Arg Gly Ala 
    1895                 1900                 1905             


Arg Val  Phe Leu Arg Gln Lys  Ser Ser Thr Ser Leu  Ser Asn Gly 
    1910                 1915                 1920             


Gly Ala  Ile Gln Asn Gln Glu  Ser Gly Ile Lys Glu  Ser Val Ser 
    1925                 1930                 1935             


Trp Gly  Thr Gln Arg Thr Gln  Asp Ala Pro His Glu  Ala Arg Pro 
    1940                 1945                 1950             


Pro Leu  Glu Arg Gly His Ser  Thr Glu Ile Pro Val  Gly Arg Ser 
    1955                 1960                 1965             


Gly Ala  Leu Ala Val Asp Val  Gln Met Gln Ser Ile  Thr Arg Arg 
    1970                 1975                 1980             


Gly Pro  Asp Gly Glu Pro Gln  Pro Gly Leu Glu Ser  Gln Gly Arg 
    1985                 1990                 1995             


Ala Ala  Ser Met Pro Arg Leu  Ala Ala Glu Thr Gln  Pro Val Thr 
    2000                 2005                 2010             


Asp Ala  Ser Pro Met Lys Arg  Ser Ile Ser Thr Leu  Ala Gln Arg 
    2015                 2020                 2025             


Pro Arg  Gly Thr His Leu Cys  Ser Thr Thr Pro Asp  Arg Pro Pro 
    2030                 2035                 2040             


Pro Ser  Gln Ala Ser Ser His  His His His His Arg  Cys His Arg 
    2045                 2050                 2055             


Arg Arg  Asp Arg Lys Gln Arg  Ser Leu Glu Lys Gly  Pro Ser Leu 
    2060                 2065                 2070             


Ser Ala  Asp Met Asp Gly Ala  Pro Ser Ser Ala Val  Gly Pro Gly 
    2075                 2080                 2085             


Leu Pro  Pro Gly Glu Gly Pro  Thr Gly Cys Arg Arg  Glu Arg Glu 
    2090                 2095                 2100             


Arg Arg  Gln Glu Arg Gly Arg  Ser Gln Glu Arg Arg  Gln Pro Ser 
    2105                 2110                 2115             


Ser Ser  Ser Ser Glu Lys Gln  Arg Phe Tyr Ser Cys  Asp Arg Phe 
    2120                 2125                 2130             


Gly Gly  Arg Glu Pro Pro Lys  Pro Lys Pro Ser Leu  Ser Ser His 
    2135                 2140                 2145             


Pro Thr  Ser Pro Thr Ala Gly  Gln Glu Pro Gly Pro  His Pro Gln 
    2150                 2155                 2160             


Gly Ser  Gly Ser Val Asn Gly  Ser Pro Leu Leu Ser  Thr Ser Gly 
    2165                 2170                 2175             


Ala Ser  Thr Pro Gly Arg Gly  Gly Arg Arg Gln Leu  Pro Gln Thr 
    2180                 2185                 2190             


Pro Leu  Thr Pro Arg Pro Ser  Ile Thr Tyr Lys Thr  Ala Asn Ser 
    2195                 2200                 2205             


Ser Pro  Ile His Phe Ala Gly  Ala Gln Thr Ser Leu  Pro Ala Phe 
    2210                 2215                 2220             


Ser Pro  Gly Arg Leu Ser Arg  Gly Leu Ser Glu His  Asn Ala Leu 
    2225                 2230                 2235             


Leu Gln  Arg Asp Pro Leu Ser  Gln Pro Leu Ala Pro  Gly Ser Arg 
    2240                 2245                 2250             


Ile Gly  Ser Asp Pro Tyr Leu  Gly Gln Arg Leu Asp  Ser Glu Ala 
    2255                 2260                 2265             


Ser Val  His Ala Leu Pro Glu  Asp Thr Leu Thr Phe  Glu Glu Ala 
    2270                 2275                 2280             


Val Ala  Thr Asn Ser Gly Arg  Ser Ser Arg Thr Ser  Tyr Val Ser 
    2285                 2290                 2295             


Ser Leu  Thr Ser Gln Ser His  Pro Leu Arg Arg Val  Pro Asn Gly 
    2300                 2305                 2310             


Tyr His  Cys Thr Leu Gly Leu  Ser Ser Gly Gly Arg  Ala Arg His 
    2315                 2320                 2325             


Ser Tyr  His His Pro Asp Gln  Asp His Trp Cys 
    2330                 2335                 


<210> 17
<211> 2251
<212> PRT
<213> Homo sapiens

<400> 17
Met Ala Arg Phe Gly Glu Ala Val Val Ala Arg Pro Gly Ser Gly Asp 
1               5                   10                  15      


Gly Asp Ser Asp Gln Ser Arg Asn Arg Gln Gly Thr Pro Val Pro Ala 
            20                  25                  30          


Ser Gly Gln Ala Ala Ala Tyr Lys Gln Thr Lys Ala Gln Arg Ala Arg 
        35                  40                  45              


Thr Met Ala Leu Tyr Asn Pro Ile Pro Val Arg Gln Asn Cys Phe Thr 
    50                  55                  60                  


Val Asn Arg Ser Leu Phe Ile Phe Gly Glu Asp Asn Ile Val Arg Lys 
65                  70                  75                  80  


Tyr Ala Lys Lys Leu Ile Asp Trp Pro Pro Phe Glu Tyr Met Ile Leu 
                85                  90                  95      


Ala Thr Ile Ile Ala Asn Cys Ile Val Leu Ala Leu Glu Gln His Leu 
            100                 105                 110         


Pro Glu Asp Asp Lys Thr Pro Met Ser Arg Arg Leu Glu Lys Thr Glu 
        115                 120                 125             


Pro Tyr Phe Ile Gly Ile Phe Cys Phe Glu Ala Gly Ile Lys Ile Val 
    130                 135                 140                 


Ala Leu Gly Phe Ile Phe His Lys Gly Ser Tyr Leu Arg Asn Gly Trp 
145                 150                 155                 160 


Asn Val Met Asp Phe Ile Val Val Leu Ser Gly Ile Leu Ala Thr Ala 
                165                 170                 175     


Gly Thr His Phe Asn Thr His Val Asp Leu Arg Thr Leu Arg Ala Val 
            180                 185                 190         


Arg Val Leu Arg Pro Leu Lys Leu Val Ser Gly Ile Pro Ser Leu Gln 
        195                 200                 205             


Ile Val Leu Lys Ser Ile Met Lys Ala Met Val Pro Leu Leu Gln Ile 
    210                 215                 220                 


Gly Leu Leu Leu Phe Phe Ala Ile Leu Met Phe Ala Ile Ile Gly Leu 
225                 230                 235                 240 


Glu Phe Tyr Ser Gly Lys Leu His Arg Ala Cys Phe Met Asn Asn Ser 
                245                 250                 255     


Gly Ile Leu Glu Gly Phe Asp Pro Pro His Pro Cys Gly Val Gln Gly 
            260                 265                 270         


Cys Pro Ala Gly Tyr Glu Cys Lys Asp Trp Ile Gly Pro Asn Asp Gly 
        275                 280                 285             


Ile Thr Gln Phe Asp Asn Ile Leu Phe Ala Val Leu Thr Val Phe Gln 
    290                 295                 300                 


Cys Ile Thr Met Glu Gly Trp Thr Thr Val Leu Tyr Asn Thr Asn Asp 
305                 310                 315                 320 


Ala Leu Gly Ala Thr Trp Asn Trp Leu Tyr Phe Ile Pro Leu Ile Ile 
                325                 330                 335     


Ile Gly Ser Phe Phe Val Leu Asn Leu Val Leu Gly Val Leu Ser Gly 
            340                 345                 350         


Glu Phe Ala Lys Glu Arg Glu Arg Val Glu Asn Arg Arg Ala Phe Met 
        355                 360                 365             


Lys Leu Arg Arg Gln Gln Gln Ile Glu Arg Glu Leu Asn Gly Tyr Arg 
    370                 375                 380                 


Ala Trp Ile Asp Lys Ala Glu Glu Val Met Leu Ala Glu Glu Asn Lys 
385                 390                 395                 400 


Asn Ala Gly Thr Ser Ala Leu Glu Val Leu Arg Arg Ala Thr Ile Lys 
                405                 410                 415     


Arg Ser Arg Thr Glu Ala Met Thr Arg Asp Ser Ser Asp Glu His Cys 
            420                 425                 430         


Val Asp Ile Ser Ser Val Gly Thr Pro Leu Ala Arg Ala Ser Ile Lys 
        435                 440                 445             


Ser Ala Lys Val Asp Gly Val Ser Tyr Phe Arg His Lys Glu Arg Leu 
    450                 455                 460                 


Leu Arg Ile Ser Ile Arg His Met Val Lys Ser Gln Val Phe Tyr Trp 
465                 470                 475                 480 


Ile Val Leu Ser Leu Val Ala Leu Asn Thr Ala Cys Val Ala Ile Val 
                485                 490                 495     


His His Asn Gln Pro Gln Trp Leu Thr His Leu Leu Tyr Tyr Ala Glu 
            500                 505                 510         


Phe Leu Phe Leu Gly Leu Phe Leu Leu Glu Met Ser Leu Lys Met Tyr 
        515                 520                 525             


Gly Met Gly Pro Arg Leu Tyr Phe His Ser Ser Phe Asn Cys Phe Asp 
    530                 535                 540                 


Phe Gly Val Thr Val Gly Ser Ile Phe Glu Val Val Trp Ala Ile Phe 
545                 550                 555                 560 


Arg Pro Gly Thr Ser Phe Gly Ile Ser Val Leu Arg Ala Leu Arg Leu 
                565                 570                 575     


Leu Arg Ile Phe Lys Ile Thr Lys Tyr Trp Ala Ser Leu Arg Asn Leu 
            580                 585                 590         


Val Val Ser Leu Met Ser Ser Met Lys Ser Ile Ile Ser Leu Leu Phe 
        595                 600                 605             


Leu Leu Phe Leu Phe Ile Val Val Phe Ala Leu Leu Gly Met Gln Leu 
    610                 615                 620                 


Phe Gly Gly Arg Phe Asn Phe Asn Asp Gly Thr Pro Ser Ala Asn Phe 
625                 630                 635                 640 


Asp Thr Phe Pro Ala Ala Ile Met Thr Val Phe Gln Ile Leu Thr Gly 
                645                 650                 655     


Glu Asp Trp Asn Glu Val Met Tyr Asn Gly Ile Arg Ser Gln Gly Gly 
            660                 665                 670         


Val Ser Ser Gly Met Trp Ser Ala Ile Tyr Phe Ile Val Leu Thr Leu 
        675                 680                 685             


Phe Gly Asn Tyr Thr Leu Leu Asn Val Phe Leu Ala Ile Ala Val Asp 
    690                 695                 700                 


Asn Leu Ala Asn Ala Gln Glu Leu Thr Lys Asp Glu Gln Glu Glu Glu 
705                 710                 715                 720 


Glu Ala Phe Asn Gln Lys His Ala Leu Gln Lys Ala Lys Glu Val Ser 
                725                 730                 735     


Pro Met Ser Ala Pro Asn Met Pro Ser Ile Glu Arg Glu Arg Arg Arg 
            740                 745                 750         


Arg His His Met Ser Val Trp Glu Gln Arg Thr Ser Gln Leu Arg Lys 
        755                 760                 765             


His Met Gln Met Ser Ser Gln Glu Ala Leu Asn Arg Glu Glu Ala Pro 
    770                 775                 780                 


Thr Met Asn Pro Leu Asn Pro Leu Asn Pro Leu Ser Ser Leu Asn Pro 
785                 790                 795                 800 


Leu Asn Ala His Pro Ser Leu Tyr Arg Arg Pro Arg Ala Ile Glu Gly 
                805                 810                 815     


Leu Ala Leu Gly Leu Ala Leu Glu Lys Phe Glu Glu Glu Arg Ile Ser 
            820                 825                 830         


Arg Gly Gly Ser Leu Lys Gly Asp Gly Gly Asp Arg Ser Ser Ala Leu 
        835                 840                 845             


Asp Asn Gln Arg Thr Pro Leu Ser Leu Gly Gln Arg Glu Pro Pro Trp 
    850                 855                 860                 


Leu Ala Arg Pro Cys His Gly Asn Cys Asp Pro Thr Gln Gln Glu Ala 
865                 870                 875                 880 


Gly Gly Gly Glu Ala Val Val Thr Phe Glu Asp Arg Ala Arg His Arg 
                885                 890                 895     


Gln Ser Gln Arg Arg Ser Arg His Arg Arg Val Arg Thr Glu Gly Lys 
            900                 905                 910         


Glu Ser Ser Ser Ala Ser Arg Ser Arg Ser Ala Ser Gln Glu Arg Ser 
        915                 920                 925             


Leu Asp Glu Ala Met Pro Thr Glu Gly Glu Lys Asp His Glu Leu Arg 
    930                 935                 940                 


Gly Asn His Gly Ala Lys Glu Pro Thr Ile Gln Glu Glu Arg Ala Gln 
945                 950                 955                 960 


Asp Leu Arg Arg Thr Asn Ser Leu Met Val Ser Arg Gly Ser Gly Leu 
                965                 970                 975     


Ala Gly Gly Leu Asp Glu Ala Asp Thr Pro Leu Val Leu Pro His Pro 
            980                 985                 990         


Glu Leu Glu Val Gly Lys His Val  Val Leu Thr Glu Gln  Glu Pro Glu 
        995                 1000                 1005             


Gly Ser  Ser Glu Gln Ala Leu  Leu Gly Asn Val Gln  Leu Asp Met 
    1010                 1015                 1020             


Gly Arg  Val Ile Ser Gln Ser  Glu Pro Asp Leu Ser  Cys Ile Thr 
    1025                 1030                 1035             


Ala Asn  Thr Asp Lys Ala Thr  Thr Glu Ser Thr Ser  Val Thr Val 
    1040                 1045                 1050             


Ala Ile  Pro Asp Val Asp Pro  Leu Val Asp Ser Thr  Val Val His 
    1055                 1060                 1065             


Ile Ser  Asn Lys Thr Asp Gly  Glu Ala Ser Pro Leu  Lys Glu Ala 
    1070                 1075                 1080             


Glu Ile  Arg Glu Asp Glu Glu  Glu Val Glu Lys Lys  Lys Gln Lys 
    1085                 1090                 1095             


Lys Glu  Lys Arg Glu Thr Gly  Lys Ala Met Val Pro  His Ser Ser 
    1100                 1105                 1110             


Met Phe  Ile Phe Ser Thr Thr  Asn Pro Ile Arg Arg  Ala Cys His 
    1115                 1120                 1125             


Tyr Ile  Val Asn Leu Arg Tyr  Phe Glu Met Cys Ile  Leu Leu Val 
    1130                 1135                 1140             


Ile Ala  Ala Ser Ser Ile Ala  Leu Ala Ala Glu Asp  Pro Val Leu 
    1145                 1150                 1155             


Thr Asn  Ser Glu Arg Asn Lys  Val Leu Arg Tyr Phe  Asp Tyr Val 
    1160                 1165                 1170             


Phe Thr  Gly Val Phe Thr Phe  Glu Met Val Ile Lys  Met Ile Asp 
    1175                 1180                 1185             


Gln Gly  Leu Ile Leu Gln Asp  Gly Ser Tyr Phe Arg  Asp Leu Trp 
    1190                 1195                 1200             


Asn Ile  Leu Asp Phe Val Val  Val Val Gly Ala Leu  Val Ala Phe 
    1205                 1210                 1215             


Ala Leu  Ala Asn Ala Leu Gly  Thr Asn Lys Gly Arg  Asp Ile Lys 
    1220                 1225                 1230             


Thr Ile  Lys Ser Leu Arg Val  Leu Arg Val Leu Arg  Pro Leu Lys 
    1235                 1240                 1245             


Thr Ile  Lys Arg Leu Pro Lys  Leu Lys Ala Val Phe  Asp Cys Val 
    1250                 1255                 1260             


Val Thr  Ser Leu Lys Asn Val  Phe Asn Ile Leu Ile  Val Tyr Lys 
    1265                 1270                 1275             


Leu Phe  Met Phe Ile Phe Ala  Val Ile Ala Val Gln  Leu Phe Lys 
    1280                 1285                 1290             


Gly Lys  Phe Phe Tyr Cys Thr  Asp Ser Ser Lys Asp  Thr Glu Lys 
    1295                 1300                 1305             


Glu Cys  Ile Gly Asn Tyr Val  Asp His Glu Lys Asn  Lys Met Glu 
    1310                 1315                 1320             


Val Lys  Gly Arg Glu Trp Lys  Arg His Glu Phe His  Tyr Asp Asn 
    1325                 1330                 1335             


Ile Ile  Trp Ala Leu Leu Thr  Leu Phe Thr Val Ser  Thr Gly Glu 
    1340                 1345                 1350             


Gly Trp  Pro Gln Val Leu Gln  His Ser Val Asp Val  Thr Glu Glu 
    1355                 1360                 1365             


Asp Arg  Gly Pro Ser Arg Ser  Asn Arg Met Glu Met  Ser Ile Phe 
    1370                 1375                 1380             


Tyr Val  Val Tyr Phe Val Val  Phe Pro Phe Phe Phe  Val Asn Ile 
    1385                 1390                 1395             


Phe Val  Ala Leu Ile Ile Ile  Thr Phe Gln Glu Gln  Gly Asp Lys 
    1400                 1405                 1410             


Met Met  Glu Glu Cys Ser Leu  Glu Lys Asn Glu Arg  Ala Cys Ile 
    1415                 1420                 1425             


Asp Phe  Ala Ile Ser Ala Lys  Pro Leu Thr Arg Tyr  Met Pro Gln 
    1430                 1435                 1440             


Asn Arg  His Thr Phe Gln Tyr  Arg Val Trp His Phe  Val Val Ser 
    1445                 1450                 1455             


Pro Ser  Phe Glu Tyr Thr Ile  Met Ala Met Ile Ala  Leu Asn Thr 
    1460                 1465                 1470             


Val Val  Leu Met Met Lys Tyr  Tyr Ser Ala Pro Cys  Thr Tyr Glu 
    1475                 1480                 1485             


Leu Ala  Leu Lys Tyr Leu Asn  Ile Ala Phe Thr Met  Val Phe Ser 
    1490                 1495                 1500             


Leu Glu  Cys Val Leu Lys Val  Ile Ala Phe Gly Phe  Leu Asn Tyr 
    1505                 1510                 1515             


Phe Arg  Asp Thr Trp Asn Ile  Phe Asp Phe Ile Thr  Val Ile Gly 
    1520                 1525                 1530             


Ser Ile  Thr Glu Ile Ile Leu  Thr Asp Ser Lys Leu  Val Asn Thr 
    1535                 1540                 1545             


Ser Gly  Phe Asn Met Ser Phe  Leu Lys Leu Phe Arg  Ala Ala Arg 
    1550                 1555                 1560             


Leu Ile  Lys Leu Leu Arg Gln  Gly Tyr Thr Ile Arg  Ile Leu Leu 
    1565                 1570                 1575             


Trp Thr  Phe Val Gln Ser Phe  Lys Ala Leu Pro Tyr  Val Cys Leu 
    1580                 1585                 1590             


Leu Ile  Ala Met Leu Phe Phe  Ile Tyr Ala Ile Ile  Gly Met Gln 
    1595                 1600                 1605             


Val Phe  Gly Asn Ile Lys Leu  Asp Glu Glu Ser His  Ile Asn Arg 
    1610                 1615                 1620             


His Asn  Asn Phe Arg Ser Phe  Phe Gly Ser Leu Met  Leu Leu Phe 
    1625                 1630                 1635             


Arg Ser  Ala Thr Gly Glu Ala  Trp Gln Glu Ile Met  Leu Ser Cys 
    1640                 1645                 1650             


Leu Gly  Glu Lys Gly Cys Glu  Pro Asp Thr Thr Ala  Pro Ser Gly 
    1655                 1660                 1665             


Gln Asn  Glu Asn Glu Arg Cys  Gly Thr Asp Leu Ala  Tyr Val Tyr 
    1670                 1675                 1680             


Phe Val  Ser Phe Ile Phe Phe  Cys Ser Phe Leu Met  Leu Asn Leu 
    1685                 1690                 1695             


Phe Val  Ala Val Ile Met Asp  Asn Phe Glu Tyr Leu  Thr Arg Asp 
    1700                 1705                 1710             


Ser Ser  Ile Leu Gly Pro His  His Leu Asp Glu Phe  Val Arg Val 
    1715                 1720                 1725             


Trp Ala  Glu Tyr Asp Arg Ala  Ala Cys Gly Arg Ile  His Tyr Thr 
    1730                 1735                 1740             


Glu Met  Tyr Glu Met Leu Thr  Leu Met Ser Pro Pro  Leu Gly Leu 
    1745                 1750                 1755             


Gly Lys  Arg Cys Pro Ser Lys  Val Ala Tyr Lys Arg  Leu Val Leu 
    1760                 1765                 1770             


Met Asn  Met Pro Val Ala Glu  Asp Met Thr Val His  Phe Thr Ser 
    1775                 1780                 1785             


Thr Leu  Met Ala Leu Ile Arg  Thr Ala Leu Asp Ile  Lys Ile Ala 
    1790                 1795                 1800             


Lys Gly  Gly Ala Asp Arg Gln  Gln Leu Asp Ser Glu  Leu Gln Lys 
    1805                 1810                 1815             


Glu Thr  Leu Ala Ile Trp Pro  His Leu Ser Gln Lys  Met Leu Asp 
    1820                 1825                 1830             


Leu Leu  Val Pro Met Pro Lys  Ala Ser Asp Leu Thr  Val Gly Lys 
    1835                 1840                 1845             


Ile Tyr  Ala Ala Met Met Ile  Met Asp Tyr Tyr Lys  Gln Ser Lys 
    1850                 1855                 1860             


Val Lys  Lys Gln Arg Gln Gln  Leu Glu Glu Gln Lys  Asn Ala Pro 
    1865                 1870                 1875             


Met Phe  Gln Arg Met Glu Pro  Ser Ser Leu Pro Gln  Glu Ile Ile 
    1880                 1885                 1890             


Ala Asn  Ala Lys Ala Leu Pro  Tyr Leu Gln Gln Asp  Pro Val Ser 
    1895                 1900                 1905             


Gly Leu  Ser Gly Arg Ser Gly  Tyr Pro Ser Met Ser  Pro Leu Ser 
    1910                 1915                 1920             


Pro Gln  Asp Ile Phe Gln Leu  Ala Cys Met Asp Pro  Ala Asp Asp 
    1925                 1930                 1935             


Gly Gln  Phe Gln Glu Arg Gln  Ser Leu Val Val Thr  Asp Pro Ser 
    1940                 1945                 1950             


Ser Met  Arg Arg Ser Phe Ser  Thr Ile Arg Asp Lys  Arg Ser Asn 
    1955                 1960                 1965             


Ser Ser  Trp Leu Glu Glu Phe  Ser Met Glu Arg Ser  Ser Glu Asn 
    1970                 1975                 1980             


Thr Tyr  Lys Ser Arg Arg Arg  Ser Tyr His Ser Ser  Leu Arg Leu 
    1985                 1990                 1995             


Ser Ala  His Arg Leu Asn Ser  Asp Ser Gly His Lys  Ser Asp Thr 
    2000                 2005                 2010             


His Pro  Ser Gly Gly Arg Glu  Arg Arg Arg Ser Lys  Glu Arg Lys 
    2015                 2020                 2025             


His Leu  Leu Ser Pro Asp Val  Ser Arg Cys Asn Ser  Glu Glu Arg 
    2030                 2035                 2040             


Gly Thr  Gln Ala Asp Trp Glu  Ser Pro Glu Arg Arg  Gln Ser Arg 
    2045                 2050                 2055             


Ser Pro  Ser Glu Gly Arg Ser  Gln Thr Pro Asn Arg  Gln Gly Thr 
    2060                 2065                 2070             


Gly Ser  Leu Ser Glu Ser Ser  Ile Pro Ser Val Ser  Asp Thr Ser 
    2075                 2080                 2085             


Thr Pro  Arg Arg Ser Arg Arg  Gln Leu Pro Pro Val  Pro Pro Lys 
    2090                 2095                 2100             


Pro Arg  Pro Leu Leu Ser Tyr  Ser Ser Leu Ile Arg  His Ala Gly 
    2105                 2110                 2115             


Ser Ile  Ser Pro Pro Ala Asp  Gly Ser Glu Glu Gly  Ser Pro Leu 
    2120                 2125                 2130             


Thr Ser  Gln Ala Leu Glu Ser  Asn Asn Ala Trp Leu  Thr Glu Ser 
    2135                 2140                 2145             


Ser Asn  Ser Pro His Pro Gln  Gln Arg Gln His Ala  Ser Pro Gln 
    2150                 2155                 2160             


Arg Tyr  Ile Ser Glu Pro Tyr  Leu Ala Leu His Glu  Asp Ser His 
    2165                 2170                 2175             


Ala Ser  Asp Cys Val Glu Glu  Glu Thr Leu Thr Phe  Glu Ala Ala 
    2180                 2185                 2190             


Val Ala  Thr Ser Leu Gly Arg  Ser Asn Thr Ile Gly  Ser Ala Pro 
    2195                 2200                 2205             


Pro Leu  Arg His Ser Trp Gln  Met Pro Asn Gly His  Tyr Arg Arg 
    2210                 2215                 2220             


Arg Arg  Arg Gly Gly Pro Gly  Pro Gly Met Met Cys  Gly Ala Val 
    2225                 2230                 2235             


Asn Asn  Leu Leu Ser Asp Thr  Glu Glu Asp Asp Lys  Cys 
    2240                 2245                 2250     


<210> 18
<211> 2377
<212> PRT
<213> Homo sapiens

<400> 18
Met Asp Glu Glu Glu Asp Gly Ala Gly Ala Glu Glu Ser Gly Gln Pro 
1               5                   10                  15      


Arg Ser Phe Met Arg Leu Asn Asp Leu Ser Gly Ala Gly Gly Arg Pro 
            20                  25                  30          


Gly Pro Gly Ser Ala Glu Lys Asp Pro Gly Ser Ala Asp Ser Glu Ala 
        35                  40                  45              


Glu Gly Leu Pro Tyr Pro Ala Leu Ala Pro Val Val Phe Phe Tyr Leu 
    50                  55                  60                  


Ser Gln Asp Ser Arg Pro Arg Ser Trp Cys Leu Arg Thr Val Cys Asn 
65                  70                  75                  80  


Pro Trp Phe Glu Arg Ile Ser Met Leu Val Ile Leu Leu Asn Cys Val 
                85                  90                  95      


Thr Leu Gly Met Phe Arg Pro Cys Glu Asp Ile Ala Cys Asp Ser Gln 
            100                 105                 110         


Arg Cys Arg Ile Leu Gln Ala Phe Asp Asp Phe Ile Phe Ala Phe Phe 
        115                 120                 125             


Ala Val Glu Met Val Val Lys Met Val Ala Leu Gly Ile Phe Gly Lys 
    130                 135                 140                 


Lys Cys Tyr Leu Gly Asp Thr Trp Asn Arg Leu Asp Phe Phe Ile Val 
145                 150                 155                 160 


Ile Ala Gly Met Leu Glu Tyr Ser Leu Asp Leu Gln Asn Val Ser Phe 
                165                 170                 175     


Ser Ala Val Arg Thr Val Arg Val Leu Arg Pro Leu Arg Ala Ile Asn 
            180                 185                 190         


Arg Val Pro Ser Met Arg Ile Leu Val Thr Leu Leu Leu Asp Thr Leu 
        195                 200                 205             


Pro Met Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val Phe Phe Ile 
    210                 215                 220                 


Phe Gly Ile Val Gly Val Gln Leu Trp Ala Gly Leu Leu Arg Asn Arg 
225                 230                 235                 240 


Cys Phe Leu Pro Glu Asn Phe Ser Leu Pro Leu Ser Val Asp Leu Glu 
                245                 250                 255     


Arg Tyr Tyr Gln Thr Glu Asn Glu Asp Glu Ser Pro Phe Ile Cys Ser 
            260                 265                 270         


Gln Pro Arg Glu Asn Gly Met Arg Ser Cys Arg Ser Val Pro Thr Leu 
        275                 280                 285             


Arg Gly Asp Gly Gly Gly Gly Pro Pro Cys Gly Leu Asp Tyr Glu Ala 
    290                 295                 300                 


Tyr Asn Ser Ser Ser Asn Thr Thr Cys Val Asn Trp Asn Gln Tyr Tyr 
305                 310                 315                 320 


Thr Asn Cys Ser Ala Gly Glu His Asn Pro Phe Lys Gly Ala Ile Asn 
                325                 330                 335     


Phe Asp Asn Ile Gly Tyr Ala Trp Ile Ala Ile Phe Gln Val Ile Thr 
            340                 345                 350         


Leu Glu Gly Trp Val Asp Ile Met Tyr Phe Val Met Asp Ala His Ser 
        355                 360                 365             


Phe Tyr Asn Phe Ile Tyr Phe Ile Leu Leu Ile Ile Val Gly Ser Phe 
    370                 375                 380                 


Phe Met Ile Asn Leu Cys Leu Val Val Ile Ala Thr Gln Phe Ser Glu 
385                 390                 395                 400 


Thr Lys Gln Arg Glu Ser Gln Leu Met Arg Glu Gln Arg Val Arg Phe 
                405                 410                 415     


Leu Ser Asn Ala Ser Thr Leu Ala Ser Phe Ser Glu Pro Gly Ser Cys 
            420                 425                 430         


Tyr Glu Glu Leu Leu Lys Tyr Leu Val Tyr Ile Leu Arg Lys Ala Ala 
        435                 440                 445             


Arg Arg Leu Ala Gln Val Ser Arg Ala Ala Gly Val Arg Val Gly Leu 
    450                 455                 460                 


Leu Ser Ser Pro Ala Pro Leu Gly Gly Gln Glu Thr Gln Pro Ser Ser 
465                 470                 475                 480 


Ser Cys Ser Arg Ser His Arg Arg Leu Ser Val His His Leu Val His 
                485                 490                 495     


His His His His His His His His Tyr His Leu Gly Asn Gly Thr Leu 
            500                 505                 510         


Arg Ala Pro Arg Ala Ser Pro Glu Ile Gln Asp Arg Asp Ala Asn Gly 
        515                 520                 525             


Ser Arg Arg Leu Met Leu Pro Pro Pro Ser Thr Pro Ala Leu Ser Gly 
    530                 535                 540                 


Ala Pro Pro Gly Gly Ala Glu Ser Val His Ser Phe Tyr His Ala Asp 
545                 550                 555                 560 


Cys His Leu Glu Pro Val Arg Cys Gln Ala Pro Pro Pro Arg Ser Pro 
                565                 570                 575     


Ser Glu Ala Ser Gly Arg Thr Val Gly Ser Gly Lys Val Tyr Pro Thr 
            580                 585                 590         


Val His Thr Ser Pro Pro Pro Glu Thr Leu Lys Glu Lys Ala Leu Val 
        595                 600                 605             


Glu Val Ala Ala Ser Ser Gly Pro Pro Thr Leu Thr Ser Leu Asn Ile 
    610                 615                 620                 


Pro Pro Gly Pro Tyr Ser Ser Met His Lys Leu Leu Glu Thr Gln Ser 
625                 630                 635                 640 


Thr Gly Ala Cys Gln Ser Ser Cys Lys Ile Ser Ser Pro Cys Leu Lys 
                645                 650                 655     


Ala Asp Ser Gly Ala Cys Gly Pro Asp Ser Cys Pro Tyr Cys Ala Arg 
            660                 665                 670         


Ala Gly Ala Gly Glu Val Glu Leu Ala Asp Arg Glu Met Pro Asp Ser 
        675                 680                 685             


Asp Ser Glu Ala Val Tyr Glu Phe Thr Gln Asp Ala Gln His Ser Asp 
    690                 695                 700                 


Leu Arg Asp Pro His Ser Arg Arg Gln Arg Ser Leu Gly Pro Asp Ala 
705                 710                 715                 720 


Glu Pro Ser Ser Val Leu Ala Phe Trp Arg Leu Ile Cys Asp Thr Phe 
                725                 730                 735     


Arg Lys Ile Val Asp Ser Lys Tyr Phe Gly Arg Gly Ile Met Ile Ala 
            740                 745                 750         


Ile Leu Val Asn Thr Leu Ser Met Gly Ile Glu Tyr His Glu Gln Pro 
        755                 760                 765             


Glu Glu Leu Thr Asn Ala Leu Glu Ile Ser Asn Ile Val Phe Thr Ser 
    770                 775                 780                 


Leu Phe Ala Leu Glu Met Leu Leu Lys Leu Leu Val Tyr Gly Pro Phe 
785                 790                 795                 800 


Gly Tyr Ile Lys Asn Pro Tyr Asn Ile Phe Asp Gly Val Ile Val Val 
                805                 810                 815     


Ile Ser Val Trp Glu Ile Val Gly Gln Gln Gly Gly Gly Leu Ser Val 
            820                 825                 830         


Leu Arg Thr Phe Arg Leu Met Arg Val Leu Lys Leu Val Arg Phe Leu 
        835                 840                 845             


Pro Ala Leu Gln Arg Gln Leu Val Val Leu Met Lys Thr Met Asp Asn 
    850                 855                 860                 


Val Ala Thr Phe Cys Met Leu Leu Met Leu Phe Ile Phe Ile Phe Ser 
865                 870                 875                 880 


Ile Leu Gly Met His Leu Phe Gly Cys Lys Phe Ala Ser Glu Arg Asp 
                885                 890                 895     


Gly Asp Thr Leu Pro Asp Arg Lys Asn Phe Asp Ser Leu Leu Trp Ala 
            900                 905                 910         


Ile Val Thr Val Phe Gln Ile Leu Thr Gln Glu Asp Trp Asn Lys Val 
        915                 920                 925             


Leu Tyr Asn Gly Met Ala Ser Thr Ser Ser Trp Ala Ala Leu Tyr Phe 
    930                 935                 940                 


Ile Ala Leu Met Thr Phe Gly Asn Tyr Val Leu Phe Asn Leu Leu Val 
945                 950                 955                 960 


Ala Ile Leu Val Glu Gly Phe Gln Ala Glu Glu Ile Ser Lys Arg Glu 
                965                 970                 975     


Asp Ala Ser Gly Gln Leu Ser Cys Ile Gln Leu Pro Val Asp Ser Gln 
            980                 985                 990         


Gly Gly Asp Ala Asn Lys Ser Glu  Ser Glu Pro Asp Phe  Phe Ser Pro 
        995                 1000                 1005             


Ser Leu  Asp Gly Asp Gly Asp  Arg Lys Lys Cys Leu  Ala Leu Val 
    1010                 1015                 1020             


Ser Leu  Gly Glu His Pro Glu  Leu Arg Lys Ser Leu  Leu Pro Pro 
    1025                 1030                 1035             


Leu Ile  Ile His Thr Ala Ala  Thr Pro Met Ser Leu  Pro Lys Ser 
    1040                 1045                 1050             


Thr Ser  Thr Gly Leu Gly Glu  Ala Leu Gly Pro Ala  Ser Arg Arg 
    1055                 1060                 1065             


Thr Ser  Ser Ser Gly Ser Ala  Glu Pro Gly Ala Ala  His Glu Met 
    1070                 1075                 1080             


Lys Ser  Pro Pro Ser Ala Arg  Ser Ser Pro His Ser  Pro Trp Ser 
    1085                 1090                 1095             


Ala Ala  Ser Ser Trp Thr Ser  Arg Arg Ser Ser Arg  Asn Ser Leu 
    1100                 1105                 1110             


Gly Arg  Ala Pro Ser Leu Lys  Arg Arg Ser Pro Ser  Gly Glu Arg 
    1115                 1120                 1125             


Arg Ser  Leu Leu Ser Gly Glu  Gly Gln Glu Ser Gln  Asp Glu Glu 
    1130                 1135                 1140             


Glu Ser  Ser Glu Glu Glu Arg  Ala Ser Pro Ala Gly  Ser Asp His 
    1145                 1150                 1155             


Arg His  Arg Gly Ser Leu Glu  Arg Glu Ala Lys Ser  Ser Phe Asp 
    1160                 1165                 1170             


Leu Pro  Asp Thr Leu Gln Val  Pro Gly Leu His Arg  Thr Ala Ser 
    1175                 1180                 1185             


Gly Arg  Gly Ser Ala Ser Glu  His Gln Asp Cys Asn  Gly Lys Ser 
    1190                 1195                 1200             


Ala Ser  Gly Arg Leu Ala Arg  Ala Leu Arg Pro Asp  Asp Pro Pro 
    1205                 1210                 1215             


Leu Asp  Gly Asp Asp Ala Asp  Asp Glu Gly Asn Leu  Ser Lys Gly 
    1220                 1225                 1230             


Glu Arg  Val Arg Ala Trp Ile  Arg Ala Arg Leu Pro  Ala Cys Cys 
    1235                 1240                 1245             


Leu Glu  Arg Asp Ser Trp Ser  Ala Tyr Ile Phe Pro  Pro Gln Ser 
    1250                 1255                 1260             


Arg Phe  Arg Leu Leu Cys His  Arg Ile Ile Thr His  Lys Met Phe 
    1265                 1270                 1275             


Asp His  Val Val Leu Val Ile  Ile Phe Leu Asn Cys  Ile Thr Ile 
    1280                 1285                 1290             


Ala Met  Glu Arg Pro Lys Ile  Asp Pro His Ser Ala  Glu Arg Ile 
    1295                 1300                 1305             


Phe Leu  Thr Leu Ser Asn Tyr  Ile Phe Thr Ala Val  Phe Leu Ala 
    1310                 1315                 1320             


Glu Met  Thr Val Lys Val Val  Ala Leu Gly Trp Cys  Phe Gly Glu 
    1325                 1330                 1335             


Gln Ala  Tyr Leu Arg Ser Ser  Trp Asn Val Leu Asp  Gly Leu Leu 
    1340                 1345                 1350             


Val Leu  Ile Ser Val Ile Asp  Ile Leu Val Ser Met  Val Ser Asp 
    1355                 1360                 1365             


Ser Gly  Thr Lys Ile Leu Gly  Met Leu Arg Val Leu  Arg Leu Leu 
    1370                 1375                 1380             


Arg Thr  Leu Arg Pro Leu Arg  Val Ile Ser Arg Ala  Gln Gly Leu 
    1385                 1390                 1395             


Lys Leu  Val Val Glu Thr Leu  Met Ser Ser Leu Lys  Pro Ile Gly 
    1400                 1405                 1410             


Asn Ile  Val Val Ile Cys Cys  Ala Phe Phe Ile Ile  Phe Gly Ile 
    1415                 1420                 1425             


Leu Gly  Val Gln Leu Phe Lys  Gly Lys Phe Phe Val  Cys Gln Gly 
    1430                 1435                 1440             


Glu Asp  Thr Arg Asn Ile Thr  Asn Lys Ser Asp Cys  Ala Glu Ala 
    1445                 1450                 1455             


Ser Tyr  Arg Trp Val Arg His  Lys Tyr Asn Phe Asp  Asn Leu Gly 
    1460                 1465                 1470             


Gln Ala  Leu Met Ser Leu Phe  Val Leu Ala Ser Lys  Asp Gly Trp 
    1475                 1480                 1485             


Val Asp  Ile Met Tyr Asp Gly  Leu Asp Ala Val Gly  Val Asp Gln 
    1490                 1495                 1500             


Gln Pro  Ile Met Asn His Asn  Pro Trp Met Leu Leu  Tyr Phe Ile 
    1505                 1510                 1515             


Ser Phe  Leu Leu Ile Val Ala  Phe Phe Val Leu Asn  Met Phe Val 
    1520                 1525                 1530             


Gly Val  Val Val Glu Asn Phe  His Lys Cys Arg Gln  His Gln Glu 
    1535                 1540                 1545             


Glu Glu  Glu Ala Arg Arg Arg  Glu Glu Lys Arg Leu  Arg Arg Leu 
    1550                 1555                 1560             


Glu Lys  Lys Arg Arg Asn Leu  Met Leu Asp Asp Val  Ile Ala Ser 
    1565                 1570                 1575             


Gly Ser  Ser Ala Ser Ala Ala  Ser Glu Ala Gln Cys  Lys Pro Tyr 
    1580                 1585                 1590             


Tyr Ser  Asp Tyr Ser Arg Phe  Arg Leu Leu Val His  His Leu Cys 
    1595                 1600                 1605             


Thr Ser  His Tyr Leu Asp Leu  Phe Ile Thr Gly Val  Ile Gly Leu 
    1610                 1615                 1620             


Asn Val  Val Thr Met Ala Met  Glu His Tyr Gln Gln  Pro Gln Ile 
    1625                 1630                 1635             


Leu Asp  Glu Ala Leu Lys Ile  Cys Asn Tyr Ile Phe  Thr Val Ile 
    1640                 1645                 1650             


Phe Val  Leu Glu Ser Val Phe  Lys Leu Val Ala Phe  Gly Phe Arg 
    1655                 1660                 1665             


Arg Phe  Phe Gln Asp Arg Trp  Asn Gln Leu Asp Leu  Ala Ile Val 
    1670                 1675                 1680             


Leu Leu  Ser Ile Met Gly Ile  Thr Leu Glu Glu Ile  Glu Val Asn 
    1685                 1690                 1695             


Ala Ser  Leu Pro Ile Asn Pro  Thr Ile Ile Arg Ile  Met Arg Val 
    1700                 1705                 1710             


Leu Arg  Ile Ala Arg Val Leu  Lys Leu Leu Lys Met  Ala Val Gly 
    1715                 1720                 1725             


Met Arg  Ala Leu Leu Asp Thr  Val Met Gln Ala Leu  Pro Gln Val 
    1730                 1735                 1740             


Gly Asn  Leu Gly Leu Leu Phe  Met Leu Leu Phe Phe  Ile Phe Ala 
    1745                 1750                 1755             


Ala Leu  Gly Val Glu Leu Phe  Gly Asp Leu Glu Cys  Asp Glu Thr 
    1760                 1765                 1770             


His Pro  Cys Glu Gly Leu Gly  Arg His Ala Thr Phe  Arg Asn Phe 
    1775                 1780                 1785             


Gly Met  Ala Phe Leu Thr Leu  Phe Arg Val Ser Thr  Gly Asp Asn 
    1790                 1795                 1800             


Trp Asn  Gly Ile Met Lys Asp  Thr Leu Arg Asp Cys  Asp Gln Glu 
    1805                 1810                 1815             


Ser Thr  Cys Tyr Asn Thr Val  Ile Ser Pro Ile Tyr  Phe Val Ser 
    1820                 1825                 1830             


Phe Val  Leu Thr Ala Gln Phe  Val Leu Val Asn Val  Val Ile Ala 
    1835                 1840                 1845             


Val Leu  Met Lys His Leu Glu  Glu Ser Asn Lys Glu  Ala Lys Glu 
    1850                 1855                 1860             


Glu Ala  Glu Leu Glu Ala Glu  Leu Glu Leu Glu Met  Lys Thr Leu 
    1865                 1870                 1875             


Ser Pro  Gln Pro His Ser Pro  Leu Gly Ser Pro Phe  Leu Trp Pro 
    1880                 1885                 1890             


Gly Val  Glu Gly Pro Asp Ser  Pro Asp Ser Pro Lys  Pro Gly Ala 
    1895                 1900                 1905             


Leu His  Pro Ala Ala His Ala  Arg Ser Ala Ser His  Phe Ser Leu 
    1910                 1915                 1920             


Glu His  Pro Thr Asp Arg Gln  Leu Phe Asp Thr Ile  Ser Leu Leu 
    1925                 1930                 1935             


Ile Gln  Gly Ser Leu Glu Trp  Glu Leu Lys Leu Met  Asp Glu Leu 
    1940                 1945                 1950             


Ala Gly  Pro Gly Gly Gln Pro  Ser Ala Phe Pro Ser  Ala Pro Ser 
    1955                 1960                 1965             


Leu Gly  Gly Ser Asp Pro Gln  Ile Pro Leu Ala Glu  Met Glu Ala 
    1970                 1975                 1980             


Leu Ser  Leu Thr Ser Glu Ile  Val Ser Glu Pro Ser  Cys Ser Leu 
    1985                 1990                 1995             


Ala Leu  Thr Asp Asp Ser Leu  Pro Asp Asp Met His  Thr Leu Leu 
    2000                 2005                 2010             


Leu Ser  Ala Leu Glu Ser Asn  Met Gln Pro His Pro  Thr Glu Leu 
    2015                 2020                 2025             


Pro Gly  Pro Asp Leu Leu Thr  Val Arg Lys Ser Gly  Val Ser Arg 
    2030                 2035                 2040             


Thr His  Ser Leu Pro Asn Asp  Ser Tyr Met Cys Arg  His Gly Ser 
    2045                 2050                 2055             


Thr Ala  Glu Gly Pro Leu Gly  His Arg Gly Trp Gly  Leu Pro Lys 
    2060                 2065                 2070             


Ala Gln  Ser Gly Ser Val Leu  Ser Val His Ser Gln  Pro Ala Asp 
    2075                 2080                 2085             


Thr Ser  Tyr Ile Leu Gln Leu  Pro Lys Asp Ala Pro  His Leu Leu 
    2090                 2095                 2100             


Gln Pro  His Ser Ala Pro Thr  Trp Gly Thr Ile Pro  Lys Leu Pro 
    2105                 2110                 2115             


Pro Pro  Gly Arg Ser Pro Leu  Ala Gln Arg Pro Leu  Arg Arg Gln 
    2120                 2125                 2130             


Ala Ala  Ile Arg Thr Asp Ser  Leu Asp Val Gln Gly  Leu Gly Ser 
    2135                 2140                 2145             


Arg Glu  Asp Leu Leu Ala Glu  Val Ser Gly Pro Ser  Pro Pro Leu 
    2150                 2155                 2160             


Ala Arg  Ala Tyr Ser Phe Trp  Gly Gln Ser Ser Thr  Gln Ala Gln 
    2165                 2170                 2175             


Gln His  Ser Arg Ser His Ser  Lys Ile Ser Lys His  Met Thr Pro 
    2180                 2185                 2190             


Pro Ala  Pro Cys Pro Gly Pro  Glu Pro Asn Trp Gly  Lys Gly Pro 
    2195                 2200                 2205             


Pro Glu  Thr Arg Ser Ser Leu  Glu Leu Asp Thr Glu  Leu Ser Trp 
    2210                 2215                 2220             


Ile Ser  Gly Asp Leu Leu Pro  Pro Gly Gly Gln Glu  Glu Pro Pro 
    2225                 2230                 2235             


Ser Pro  Arg Asp Leu Lys Lys  Cys Tyr Ser Val Glu  Ala Gln Ser 
    2240                 2245                 2250             


Cys Gln  Arg Arg Pro Thr Ser  Trp Leu Asp Glu Gln  Arg Arg His 
    2255                 2260                 2265             


Ser Ile  Ala Val Ser Cys Leu  Asp Ser Gly Ser Gln  Pro His Leu 
    2270                 2275                 2280             


Gly Thr  Asp Pro Ser Asn Leu  Gly Gly Gln Pro Leu  Gly Gly Pro 
    2285                 2290                 2295             


Gly Ser  Arg Pro Lys Lys Lys  Leu Ser Pro Pro Ser  Ile Thr Ile 
    2300                 2305                 2310             


Asp Pro  Pro Glu Ser Gln Gly  Pro Arg Thr Pro Pro  Ser Pro Gly 
    2315                 2320                 2325             


Ile Cys  Leu Arg Arg Arg Ala  Pro Ser Ser Asp Ser  Lys Asp Pro 
    2330                 2335                 2340             


Leu Ala  Ser Gly Pro Pro Asp  Ser Met Ala Ala Ser  Pro Ser Pro 
    2345                 2350                 2355             


Lys Lys  Asp Val Leu Ser Leu  Ser Gly Leu Ser Ser  Asp Pro Ala 
    2360                 2365                 2370             


Asp Leu  Asp Pro 
    2375         


<210> 19
<211> 2353
<212> PRT
<213> Homo sapiens

<400> 19
Met Thr Glu Gly Ala Arg Ala Ala Asp Glu Val Arg Val Pro Leu Gly 
1               5                   10                  15      


Ala Pro Pro Pro Gly Pro Ala Ala Leu Val Gly Ala Ser Pro Glu Ser 
            20                  25                  30          


Pro Gly Ala Pro Gly Arg Glu Ala Glu Arg Gly Ser Glu Leu Gly Val 
        35                  40                  45              


Ser Pro Ser Glu Ser Pro Ala Ala Glu Arg Gly Ala Glu Leu Gly Ala 
    50                  55                  60                  


Asp Glu Glu Gln Arg Val Pro Tyr Pro Ala Leu Ala Ala Thr Val Phe 
65                  70                  75                  80  


Phe Cys Leu Gly Gln Thr Thr Arg Pro Arg Ser Trp Cys Leu Arg Leu 
                85                  90                  95      


Val Cys Asn Pro Trp Phe Glu His Val Ser Met Leu Val Ile Met Leu 
            100                 105                 110         


Asn Cys Val Thr Leu Gly Met Phe Arg Pro Cys Glu Asp Val Glu Cys 
        115                 120                 125             


Gly Ser Glu Arg Cys Asn Ile Leu Glu Ala Phe Asp Ala Phe Ile Phe 
    130                 135                 140                 


Ala Phe Phe Ala Val Glu Met Val Ile Lys Met Val Ala Leu Gly Leu 
145                 150                 155                 160 


Phe Gly Gln Lys Cys Tyr Leu Gly Asp Thr Trp Asn Arg Leu Asp Phe 
                165                 170                 175     


Phe Ile Val Val Ala Gly Met Met Glu Tyr Ser Leu Asp Gly His Asn 
            180                 185                 190         


Val Ser Leu Ser Ala Ile Arg Thr Val Arg Val Leu Arg Pro Leu Arg 
        195                 200                 205             


Ala Ile Asn Arg Val Pro Ser Met Arg Ile Leu Val Thr Leu Leu Leu 
    210                 215                 220                 


Asp Thr Leu Pro Met Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val 
225                 230                 235                 240 


Phe Phe Ile Phe Gly Ile Val Gly Val Gln Leu Trp Ala Gly Leu Leu 
                245                 250                 255     


Arg Asn Arg Cys Phe Leu Asp Ser Ala Phe Val Arg Asn Asn Asn Leu 
            260                 265                 270         


Thr Phe Leu Arg Pro Tyr Tyr Gln Thr Glu Glu Gly Glu Glu Asn Pro 
        275                 280                 285             


Phe Ile Cys Ser Ser Arg Arg Asp Asn Gly Met Gln Lys Cys Ser His 
    290                 295                 300                 


Ile Pro Gly Arg Arg Glu Leu Arg Met Pro Cys Thr Leu Gly Trp Glu 
305                 310                 315                 320 


Ala Tyr Thr Gln Pro Gln Ala Glu Gly Val Gly Ala Ala Arg Asn Ala 
                325                 330                 335     


Cys Ile Asn Trp Asn Gln Tyr Tyr Asn Val Cys Arg Ser Gly Asp Ser 
            340                 345                 350         


Asn Pro His Asn Gly Ala Ile Asn Phe Asp Asn Ile Gly Tyr Ala Trp 
        355                 360                 365             


Ile Ala Ile Phe Gln Val Ile Thr Leu Glu Gly Trp Val Asp Ile Met 
    370                 375                 380                 


Tyr Tyr Val Met Asp Ala His Ser Phe Tyr Asn Phe Ile Tyr Phe Ile 
385                 390                 395                 400 


Leu Leu Ile Ile Val Gly Ser Phe Phe Met Ile Asn Leu Cys Leu Val 
                405                 410                 415     


Val Ile Ala Thr Gln Phe Ser Glu Thr Lys Gln Arg Glu Ser Gln Leu 
            420                 425                 430         


Met Arg Glu Gln Arg Ala Arg His Leu Ser Asn Asp Ser Thr Leu Ala 
        435                 440                 445             


Ser Phe Ser Glu Pro Gly Ser Cys Tyr Glu Glu Leu Leu Lys Tyr Val 
    450                 455                 460                 


Gly His Ile Phe Arg Lys Val Lys Arg Arg Ser Leu Arg Leu Tyr Ala 
465                 470                 475                 480 


Arg Trp Gln Ser Arg Trp Arg Lys Lys Val Asp Pro Ser Ala Val Gln 
                485                 490                 495     


Gly Gln Gly Pro Gly His Arg Gln Arg Arg Ala Gly Arg His Thr Ala 
            500                 505                 510         


Ser Val His His Leu Val Tyr His His His His His His His His His 
        515                 520                 525             


Tyr His Phe Ser His Gly Ser Pro Arg Arg Pro Gly Pro Glu Pro Gly 
    530                 535                 540                 


Ala Cys Asp Thr Arg Leu Val Arg Ala Gly Ala Pro Pro Ser Pro Pro 
545                 550                 555                 560 


Ser Pro Gly Arg Gly Pro Pro Asp Ala Glu Ser Val His Ser Ile Tyr 
                565                 570                 575     


His Ala Asp Cys His Ile Glu Gly Pro Gln Glu Arg Ala Arg Val Ala 
            580                 585                 590         


His Ala Ala Ala Thr Ala Ala Ala Ser Leu Arg Leu Ala Thr Gly Leu 
        595                 600                 605             


Gly Thr Met Asn Tyr Pro Thr Ile Leu Pro Ser Gly Val Gly Ser Gly 
    610                 615                 620                 


Lys Gly Ser Thr Ser Pro Gly Pro Lys Gly Lys Trp Ala Gly Gly Pro 
625                 630                 635                 640 


Pro Gly Thr Gly Gly His Gly Pro Leu Ser Leu Asn Ser Pro Asp Pro 
                645                 650                 655     


Tyr Glu Lys Ile Pro His Val Val Gly Glu His Gly Leu Gly Gln Ala 
            660                 665                 670         


Pro Gly His Leu Ser Gly Leu Ser Val Pro Cys Pro Leu Pro Ser Pro 
        675                 680                 685             


Pro Ala Gly Thr Leu Thr Cys Glu Leu Lys Ser Cys Pro Tyr Cys Thr 
    690                 695                 700                 


Arg Ala Leu Glu Asp Pro Glu Gly Glu Leu Ser Gly Ser Glu Ser Gly 
705                 710                 715                 720 


Asp Ser Asp Gly Arg Gly Val Tyr Glu Phe Thr Gln Asp Val Arg His 
                725                 730                 735     


Gly Asp Arg Trp Asp Pro Thr Arg Pro Pro Arg Ala Thr Asp Thr Pro 
            740                 745                 750         


Gly Pro Gly Pro Gly Ser Pro Gln Arg Arg Ala Gln Gln Arg Ala Ala 
        755                 760                 765             


Pro Gly Glu Pro Gly Trp Met Gly Arg Leu Trp Val Thr Phe Ser Gly 
    770                 775                 780                 


Lys Leu Arg Arg Ile Val Asp Ser Lys Tyr Phe Ser Arg Gly Ile Met 
785                 790                 795                 800 


Met Ala Ile Leu Val Asn Thr Leu Ser Met Gly Val Glu Tyr His Glu 
                805                 810                 815     


Gln Pro Glu Glu Leu Thr Asn Ala Leu Glu Ile Ser Asn Ile Val Phe 
            820                 825                 830         


Thr Ser Met Phe Ala Leu Glu Met Leu Leu Lys Leu Leu Ala Cys Gly 
        835                 840                 845             


Pro Leu Gly Tyr Ile Arg Asn Pro Tyr Asn Ile Phe Asp Gly Ile Ile 
    850                 855                 860                 


Val Val Ile Ser Val Trp Glu Ile Val Gly Gln Ala Asp Gly Gly Leu 
865                 870                 875                 880 


Ser Val Leu Arg Thr Phe Arg Leu Leu Arg Val Leu Lys Leu Val Arg 
                885                 890                 895     


Phe Leu Pro Ala Leu Arg Arg Gln Leu Val Val Leu Val Lys Thr Met 
            900                 905                 910         


Asp Asn Val Ala Thr Phe Cys Thr Leu Leu Met Leu Phe Ile Phe Ile 
        915                 920                 925             


Phe Ser Ile Leu Gly Met His Leu Phe Gly Cys Lys Phe Ser Leu Lys 
    930                 935                 940                 


Thr Asp Thr Gly Asp Thr Val Pro Asp Arg Lys Asn Phe Asp Ser Leu 
945                 950                 955                 960 


Leu Trp Ala Ile Val Thr Val Phe Gln Ile Leu Thr Gln Glu Asp Trp 
                965                 970                 975     


Asn Val Val Leu Tyr Asn Gly Met Ala Ser Thr Ser Ser Trp Ala Ala 
            980                 985                 990         


Leu Tyr Phe Val Ala Leu Met Thr  Phe Gly Asn Tyr Val  Leu Phe Asn 
        995                 1000                 1005             


Leu Leu  Val Ala Ile Leu Val  Glu Gly Phe Gln Ala  Glu Gly Asp 
    1010                 1015                 1020             


Ala Asn  Arg Ser Asp Thr Asp  Glu Asp Lys Thr Ser  Val His Phe 
    1025                 1030                 1035             


Glu Glu  Asp Phe His Lys Leu  Arg Glu Leu Gln Thr  Thr Glu Leu 
    1040                 1045                 1050             


Lys Met  Cys Ser Leu Ala Val  Thr Pro Asn Gly His  Leu Glu Gly 
    1055                 1060                 1065             


Arg Gly  Ser Leu Ser Pro Pro  Leu Ile Met Cys Thr  Ala Ala Thr 
    1070                 1075                 1080             


Pro Met  Pro Thr Pro Lys Ser  Ser Pro Phe Leu Asp  Ala Ala Pro 
    1085                 1090                 1095             


Ser Leu  Pro Asp Ser Arg Arg  Gly Ser Ser Ser Ser  Gly Asp Pro 
    1100                 1105                 1110             


Pro Leu  Gly Asp Gln Lys Pro  Pro Ala Ser Leu Arg  Ser Ser Pro 
    1115                 1120                 1125             


Cys Ala  Pro Trp Gly Pro Ser  Gly Ala Trp Ser Ser  Arg Arg Ser 
    1130                 1135                 1140             


Ser Trp  Ser Ser Leu Gly Arg  Ala Pro Ser Leu Lys  Arg Arg Gly 
    1145                 1150                 1155             


Gln Cys  Gly Glu Arg Glu Ser  Leu Leu Ser Gly Glu  Gly Lys Gly 
    1160                 1165                 1170             


Ser Thr  Asp Asp Glu Ala Glu  Asp Gly Arg Ala Ala  Pro Gly Pro 
    1175                 1180                 1185             


Arg Ala  Thr Pro Leu Arg Arg  Ala Glu Ser Leu Asp  Pro Arg Pro 
    1190                 1195                 1200             


Leu Arg  Pro Ala Ala Leu Pro  Pro Thr Lys Cys Arg  Asp Arg Asp 
    1205                 1210                 1215             


Gly Gln  Val Val Ala Leu Pro  Ser Asp Phe Phe Leu  Arg Ile Asp 
    1220                 1225                 1230             


Ser His  Arg Glu Asp Ala Ala  Glu Leu Asp Asp Asp  Ser Glu Asp 
    1235                 1240                 1245             


Ser Cys  Cys Leu Arg Leu His  Lys Val Leu Glu Pro  Tyr Lys Pro 
    1250                 1255                 1260             


Gln Trp  Cys Arg Ser Arg Glu  Ala Trp Ala Leu Tyr  Leu Phe Ser 
    1265                 1270                 1275             


Pro Gln  Asn Arg Phe Arg Val  Ser Cys Gln Lys Val  Ile Thr His 
    1280                 1285                 1290             


Lys Met  Phe Asp His Val Val  Leu Val Phe Ile Phe  Leu Asn Cys 
    1295                 1300                 1305             


Val Thr  Ile Ala Leu Glu Arg  Pro Asp Ile Asp Pro  Gly Ser Thr 
    1310                 1315                 1320             


Glu Arg  Val Phe Leu Ser Val  Ser Asn Tyr Ile Phe  Thr Ala Ile 
    1325                 1330                 1335             


Phe Val  Ala Glu Met Met Val  Lys Val Val Ala Leu  Gly Leu Leu 
    1340                 1345                 1350             


Ser Gly  Glu His Ala Tyr Leu  Gln Ser Ser Trp Asn  Leu Leu Asp 
    1355                 1360                 1365             


Gly Leu  Leu Val Leu Val Ser  Leu Val Asp Ile Val  Val Ala Met 
    1370                 1375                 1380             


Ala Ser  Ala Gly Gly Ala Lys  Ile Leu Gly Val Leu  Arg Val Leu 
    1385                 1390                 1395             


Arg Leu  Leu Arg Thr Leu Arg  Pro Leu Arg Val Ile  Ser Arg Ala 
    1400                 1405                 1410             


Pro Gly  Leu Lys Leu Val Val  Glu Thr Leu Ile Ser  Ser Leu Arg 
    1415                 1420                 1425             


Pro Ile  Gly Asn Ile Val Leu  Ile Cys Cys Ala Phe  Phe Ile Ile 
    1430                 1435                 1440             


Phe Gly  Ile Leu Gly Val Gln  Leu Phe Lys Gly Lys  Phe Tyr Tyr 
    1445                 1450                 1455             


Cys Glu  Gly Pro Asp Thr Arg  Asn Ile Ser Thr Lys  Ala Gln Cys 
    1460                 1465                 1470             


Arg Ala  Ala His Tyr Arg Trp  Val Arg Arg Lys Tyr  Asn Phe Asp 
    1475                 1480                 1485             


Asn Leu  Gly Gln Ala Leu Met  Ser Leu Phe Val Leu  Ser Ser Lys 
    1490                 1495                 1500             


Asp Gly  Trp Val Asn Ile Met  Tyr Asp Gly Leu Asp  Ala Val Gly 
    1505                 1510                 1515             


Val Asp  Gln Gln Pro Val Gln  Asn His Asn Pro Trp  Met Leu Leu 
    1520                 1525                 1530             


Tyr Phe  Ile Ser Phe Leu Leu  Ile Val Ser Phe Phe  Val Leu Asn 
    1535                 1540                 1545             


Met Phe  Val Gly Val Val Val  Glu Asn Phe His Lys  Cys Arg Gln 
    1550                 1555                 1560             


His Gln  Glu Ala Glu Glu Ala  Arg Arg Arg Glu Glu  Lys Arg Leu 
    1565                 1570                 1575             


Arg Arg  Leu Glu Arg Arg Arg  Arg Ser Thr Phe Pro  Ser Pro Glu 
    1580                 1585                 1590             


Ala Gln  Arg Arg Pro Tyr Tyr  Ala Asp Tyr Ser Pro  Thr Arg Arg 
    1595                 1600                 1605             


Ser Ile  His Ser Leu Cys Thr  Ser His Tyr Leu Asp  Leu Phe Ile 
    1610                 1615                 1620             


Thr Phe  Ile Ile Cys Val Asn  Val Ile Thr Met Ser  Met Glu His 
    1625                 1630                 1635             


Tyr Asn  Gln Pro Lys Ser Leu  Asp Glu Ala Leu Lys  Tyr Cys Asn 
    1640                 1645                 1650             


Tyr Val  Phe Thr Ile Val Phe  Val Phe Glu Ala Ala  Leu Lys Leu 
    1655                 1660                 1665             


Val Ala  Phe Gly Phe Arg Arg  Phe Phe Lys Asp Arg  Trp Asn Gln 
    1670                 1675                 1680             


Leu Asp  Leu Ala Ile Val Leu  Leu Ser Leu Met Gly  Ile Thr Leu 
    1685                 1690                 1695             


Glu Glu  Ile Glu Met Ser Ala  Ala Leu Pro Ile Asn  Pro Thr Ile 
    1700                 1705                 1710             


Ile Arg  Ile Met Arg Val Leu  Arg Ile Ala Arg Val  Leu Lys Leu 
    1715                 1720                 1725             


Leu Lys  Met Ala Thr Gly Met  Arg Ala Leu Leu Asp  Thr Val Val 
    1730                 1735                 1740             


Gln Ala  Leu Pro Gln Val Gly  Asn Leu Gly Leu Leu  Phe Met Leu 
    1745                 1750                 1755             


Leu Phe  Phe Ile Tyr Ala Ala  Leu Gly Val Glu Leu  Phe Gly Arg 
    1760                 1765                 1770             


Leu Glu  Cys Ser Glu Asp Asn  Pro Cys Glu Gly Leu  Ser Arg His 
    1775                 1780                 1785             


Ala Thr  Phe Ser Asn Phe Gly  Met Ala Phe Leu Thr  Leu Phe Arg 
    1790                 1795                 1800             


Val Ser  Thr Gly Asp Asn Trp  Asn Gly Ile Met Lys  Asp Thr Leu 
    1805                 1810                 1815             


Arg Glu  Cys Ser Arg Glu Asp  Lys His Cys Leu Ser  Tyr Leu Pro 
    1820                 1825                 1830             


Ala Leu  Ser Pro Val Tyr Phe  Val Thr Phe Val Leu  Val Ala Gln 
    1835                 1840                 1845             


Phe Val  Leu Val Asn Val Val  Val Ala Val Leu Met  Lys His Leu 
    1850                 1855                 1860             


Glu Glu  Ser Asn Lys Glu Ala  Arg Glu Asp Ala Glu  Leu Asp Ala 
    1865                 1870                 1875             


Glu Ile  Glu Leu Glu Met Ala  Gln Gly Pro Gly Ser  Ala Arg Arg 
    1880                 1885                 1890             


Val Asp  Ala Asp Arg Pro Pro  Leu Pro Gln Glu Ser  Pro Gly Ala 
    1895                 1900                 1905             


Arg Asp  Ala Pro Asn Leu Val  Ala Arg Lys Val Ser  Val Ser Arg 
    1910                 1915                 1920             


Met Leu  Ser Leu Pro Asn Asp  Ser Tyr Met Phe Arg  Pro Val Val 
    1925                 1930                 1935             


Pro Ala  Ser Ala Pro His Pro  Arg Pro Leu Gln Glu  Val Glu Met 
    1940                 1945                 1950             


Glu Thr  Tyr Gly Ala Gly Thr  Pro Leu Gly Ser Val  Ala Ser Val 
    1955                 1960                 1965             


His Ser  Pro Pro Ala Glu Ser  Cys Ala Ser Leu Gln  Ile Pro Leu 
    1970                 1975                 1980             


Ala Val  Ser Ser Pro Ala Arg  Ser Gly Glu Pro Leu  His Ala Leu 
    1985                 1990                 1995             


Ser Pro  Arg Gly Thr Ala Arg  Ser Pro Ser Leu Ser  Arg Leu Leu 
    2000                 2005                 2010             


Cys Arg  Gln Glu Ala Val His  Thr Asp Ser Leu Glu  Gly Lys Ile 
    2015                 2020                 2025             


Asp Ser  Pro Arg Asp Thr Leu  Asp Pro Ala Glu Pro  Gly Glu Lys 
    2030                 2035                 2040             


Thr Pro  Val Arg Pro Val Thr  Gln Gly Gly Ser Leu  Gln Ser Pro 
    2045                 2050                 2055             


Pro Arg  Ser Pro Arg Pro Ala  Ser Val Arg Thr Arg  Lys His Thr 
    2060                 2065                 2070             


Phe Gly  Gln Arg Cys Val Ser  Ser Arg Pro Ala Ala  Pro Gly Gly 
    2075                 2080                 2085             


Glu Glu  Ala Glu Ala Ser Asp  Pro Ala Asp Glu Glu  Val Ser His 
    2090                 2095                 2100             


Ile Thr  Ser Ser Ala Cys Pro  Trp Gln Pro Thr Ala  Glu Pro His 
    2105                 2110                 2115             


Gly Pro  Glu Ala Ser Pro Val  Ala Gly Gly Glu Arg  Asp Leu Arg 
    2120                 2125                 2130             


Arg Leu  Tyr Ser Val Asp Ala  Gln Gly Phe Leu Asp  Lys Pro Gly 
    2135                 2140                 2145             


Arg Ala  Asp Glu Gln Trp Arg  Pro Ser Ala Glu Leu  Gly Ser Gly 
    2150                 2155                 2160             


Glu Pro  Gly Glu Ala Lys Ala  Trp Gly Pro Glu Ala  Glu Pro Ala 
    2165                 2170                 2175             


Leu Gly  Ala Arg Arg Lys Lys  Lys Met Ser Pro Pro  Cys Ile Ser 
    2180                 2185                 2190             


Val Glu  Pro Pro Ala Glu Asp  Glu Gly Ser Ala Arg  Pro Ser Ala 
    2195                 2200                 2205             


Ala Glu  Gly Gly Ser Thr Thr  Leu Arg Arg Arg Thr  Pro Ser Cys 
    2210                 2215                 2220             


Glu Ala  Thr Pro His Arg Asp  Ser Leu Glu Pro Thr  Glu Gly Ser 
    2225                 2230                 2235             


Gly Ala  Gly Gly Asp Pro Ala  Ala Lys Gly Glu Arg  Trp Gly Gln 
    2240                 2245                 2250             


Ala Ser  Cys Arg Ala Glu His  Leu Thr Val Pro Ser  Phe Ala Phe 
    2255                 2260                 2265             


Glu Pro  Leu Asp Leu Gly Val  Pro Ser Gly Asp Pro  Phe Leu Asp 
    2270                 2275                 2280             


Gly Ser  His Ser Val Thr Pro  Glu Ser Arg Ala Ser  Ser Ser Gly 
    2285                 2290                 2295             


Ala Ile  Val Pro Leu Glu Pro  Pro Glu Ser Glu Pro  Pro Met Pro 
    2300                 2305                 2310             


Val Gly  Asp Pro Pro Glu Lys  Arg Arg Gly Leu Tyr  Leu Thr Val 
    2315                 2320                 2325             


Pro Gln  Cys Pro Leu Glu Lys  Pro Gly Ser Pro Ser  Ala Thr Pro 
    2330                 2335                 2340             


Ala Pro  Gly Gly Gly Ala Asp  Asp Pro Val 
    2345                 2350             


<210> 20
<211> 2188
<212> PRT
<213> Homo sapiens

<400> 20
Met Ala Glu Ser Ala Ser Pro Pro Ser Ser Ser Ala Ala Ala Pro Ala 
1               5                   10                  15      


Ala Glu Pro Gly Val Thr Thr Glu Gln Pro Gly Pro Arg Ser Pro Pro 
            20                  25                  30          


Ser Ser Pro Pro Gly Leu Glu Glu Pro Leu Asp Gly Ala Asp Pro His 
        35                  40                  45              


Val Pro His Pro Asp Leu Ala Pro Ile Ala Phe Phe Cys Leu Arg Gln 
    50                  55                  60                  


Thr Thr Ser Pro Arg Asn Trp Cys Ile Lys Met Val Cys Asn Pro Trp 
65                  70                  75                  80  


Phe Glu Cys Val Ser Met Leu Val Ile Leu Leu Asn Cys Val Thr Leu 
                85                  90                  95      


Gly Met Tyr Gln Pro Cys Asp Asp Met Asp Cys Leu Ser Asp Arg Cys 
            100                 105                 110         


Lys Ile Leu Gln Val Phe Asp Asp Phe Ile Phe Ile Phe Phe Ala Met 
        115                 120                 125             


Glu Met Val Leu Lys Met Val Ala Leu Gly Ile Phe Gly Lys Lys Cys 
    130                 135                 140                 


Tyr Leu Gly Asp Thr Trp Asn Arg Leu Asp Phe Phe Ile Val Met Ala 
145                 150                 155                 160 


Gly Met Val Glu Tyr Ser Leu Asp Leu Gln Asn Ile Asn Leu Ser Ala 
                165                 170                 175     


Ile Arg Thr Val Arg Val Leu Arg Pro Leu Lys Ala Ile Asn Arg Val 
            180                 185                 190         


Pro Ser Met Arg Ile Leu Val Asn Leu Leu Leu Asp Thr Leu Pro Met 
        195                 200                 205             


Leu Gly Asn Val Leu Leu Leu Cys Phe Phe Val Phe Phe Ile Phe Gly 
    210                 215                 220                 


Ile Ile Gly Val Gln Leu Trp Ala Gly Leu Leu Arg Asn Arg Cys Phe 
225                 230                 235                 240 


Leu Glu Glu Asn Phe Thr Ile Gln Gly Asp Val Ala Leu Pro Pro Tyr 
                245                 250                 255     


Tyr Gln Pro Glu Glu Asp Asp Glu Met Pro Phe Ile Cys Ser Leu Ser 
            260                 265                 270         


Gly Asp Asn Gly Ile Met Gly Cys His Glu Ile Pro Pro Leu Lys Glu 
        275                 280                 285             


Gln Gly Arg Glu Cys Cys Leu Ser Lys Asp Asp Val Tyr Asp Phe Gly 
    290                 295                 300                 


Ala Gly Arg Gln Asp Leu Asn Ala Ser Gly Leu Cys Val Asn Trp Asn 
305                 310                 315                 320 


Arg Tyr Tyr Asn Val Cys Arg Thr Gly Ser Ala Asn Pro His Lys Gly 
                325                 330                 335     


Ala Ile Asn Phe Asp Asn Ile Gly Tyr Ala Trp Ile Val Ile Phe Gln 
            340                 345                 350         


Val Ile Thr Leu Glu Gly Trp Val Glu Ile Met Tyr Tyr Val Met Asp 
        355                 360                 365             


Ala His Ser Phe Tyr Asn Phe Ile Tyr Phe Ile Leu Leu Ile Ile Val 
    370                 375                 380                 


Gly Ser Phe Phe Met Ile Asn Leu Cys Leu Val Val Ile Ala Thr Gln 
385                 390                 395                 400 


Phe Ser Glu Thr Lys Gln Arg Glu His Arg Leu Met Leu Glu Gln Arg 
                405                 410                 415     


Gln Arg Tyr Leu Ser Ser Ser Thr Val Ala Ser Tyr Ala Glu Pro Gly 
            420                 425                 430         


Asp Cys Tyr Glu Glu Ile Phe Gln Tyr Val Cys His Ile Leu Arg Lys 
        435                 440                 445             


Ala Lys Arg Arg Ala Leu Gly Leu Tyr Gln Ala Leu Gln Ser Arg Arg 
    450                 455                 460                 


Gln Ala Leu Gly Pro Glu Ala Pro Ala Pro Ala Lys Pro Gly Pro His 
465                 470                 475                 480 


Ala Lys Glu Pro Arg His Tyr Gln Leu Cys Pro Gln His Ser Pro Leu 
                485                 490                 495     


Asp Ala Thr Pro His Thr Leu Val Gln Pro Ile Pro Ala Thr Leu Ala 
            500                 505                 510         


Ser Asp Pro Ala Ser Cys Pro Cys Cys Gln His Glu Asp Gly Arg Arg 
        515                 520                 525             


Pro Ser Gly Leu Gly Ser Thr Asp Ser Gly Gln Glu Gly Ser Gly Ser 
    530                 535                 540                 


Gly Ser Ser Ala Gly Gly Glu Asp Glu Ala Asp Gly Asp Gly Ala Arg 
545                 550                 555                 560 


Ser Ser Glu Asp Gly Ala Ser Ser Glu Leu Gly Lys Glu Glu Glu Glu 
                565                 570                 575     


Glu Glu Gln Ala Asp Gly Ala Val Trp Leu Cys Gly Asp Val Trp Arg 
            580                 585                 590         


Glu Thr Arg Ala Lys Leu Arg Gly Ile Val Asp Ser Lys Tyr Phe Asn 
        595                 600                 605             


Arg Gly Ile Met Met Ala Ile Leu Val Asn Thr Val Ser Met Gly Ile 
    610                 615                 620                 


Glu His His Glu Gln Pro Glu Glu Leu Thr Asn Ile Leu Glu Ile Cys 
625                 630                 635                 640 


Asn Val Val Phe Thr Ser Met Phe Ala Leu Glu Met Ile Leu Lys Leu 
                645                 650                 655     


Ala Ala Phe Gly Leu Phe Asp Tyr Leu Arg Asn Pro Tyr Asn Ile Phe 
            660                 665                 670         


Asp Ser Ile Ile Val Ile Ile Ser Ile Trp Glu Ile Val Gly Gln Ala 
        675                 680                 685             


Asp Gly Gly Leu Ser Val Leu Arg Thr Phe Arg Leu Leu Arg Val Leu 
    690                 695                 700                 


Lys Leu Val Arg Phe Met Pro Ala Leu Arg Arg Gln Leu Val Val Leu 
705                 710                 715                 720 


Met Lys Thr Met Asp Asn Val Ala Thr Phe Cys Met Leu Leu Met Leu 
                725                 730                 735     


Phe Ile Phe Ile Phe Ser Ile Leu Gly Met His Ile Phe Gly Cys Lys 
            740                 745                 750         


Phe Ser Leu Arg Thr Asp Thr Gly Asp Thr Val Pro Asp Arg Lys Asn 
        755                 760                 765             


Phe Asp Ser Leu Leu Trp Ala Ile Val Thr Val Phe Gln Ile Leu Thr 
    770                 775                 780                 


Gln Glu Asp Trp Asn Val Val Leu Tyr Asn Gly Met Ala Ser Thr Ser 
785                 790                 795                 800 


Pro Trp Ala Ser Leu Tyr Phe Val Ala Leu Met Thr Phe Gly Asn Tyr 
                805                 810                 815     


Val Leu Phe Asn Leu Leu Val Ala Ile Leu Val Glu Gly Phe Gln Ala 
            820                 825                 830         


Glu Gly Asp Ala Asn Arg Ser Tyr Ser Asp Glu Asp Gln Ser Ser Ser 
        835                 840                 845             


Asn Ile Glu Glu Phe Asp Lys Leu Gln Glu Gly Leu Asp Ser Ser Gly 
    850                 855                 860                 


Asp Pro Lys Leu Cys Pro Ile Pro Met Thr Pro Asn Gly His Leu Asp 
865                 870                 875                 880 


Pro Ser Leu Pro Leu Gly Gly His Leu Gly Pro Ala Gly Ala Ala Gly 
                885                 890                 895     


Pro Ala Pro Arg Leu Ser Leu Gln Pro Asp Pro Met Leu Val Ala Leu 
            900                 905                 910         


Gly Ser Arg Lys Ser Ser Val Met Ser Leu Gly Arg Met Ser Tyr Asp 
        915                 920                 925             


Gln Arg Ser Leu Ser Ser Ser Arg Ser Ser Tyr Tyr Gly Pro Trp Gly 
    930                 935                 940                 


Arg Ser Ala Ala Trp Ala Ser Arg Arg Ser Ser Trp Asn Ser Leu Lys 
945                 950                 955                 960 


His Lys Pro Pro Ser Ala Glu His Glu Ser Leu Leu Ser Ala Glu Arg 
                965                 970                 975     


Gly Gly Gly Ala Arg Val Cys Glu Val Ala Ala Asp Glu Gly Pro Pro 
            980                 985                 990         


Arg Ala Ala Pro Leu His Thr Pro  His Ala His His Val  His His Gly 
        995                 1000                 1005             


Pro His  Leu Ala His Arg His  Arg His His Arg Arg  Thr Leu Ser 
    1010                 1015                 1020             


Leu Asp  Asn Arg Asp Ser Val  Asp Leu Ala Glu Leu  Val Pro Ala 
    1025                 1030                 1035             


Val Gly  Ala His Pro Arg Ala  Ala Trp Arg Ala Ala  Gly Pro Ala 
    1040                 1045                 1050             


Pro Gly  His Glu Asp Cys Asn  Gly Arg Met Pro Ser  Ile Ala Lys 
    1055                 1060                 1065             


Asp Val  Phe Thr Lys Met Gly  Asp Arg Gly Asp Arg  Gly Glu Asp 
    1070                 1075                 1080             


Glu Glu  Glu Ile Asp Tyr Thr  Leu Cys Phe Arg Val  Arg Lys Met 
    1085                 1090                 1095             


Ile Asp  Val Tyr Lys Pro Asp  Trp Cys Glu Val Arg  Glu Asp Trp 
    1100                 1105                 1110             


Ser Val  Tyr Leu Phe Ser Pro  Glu Asn Arg Phe Arg  Val Leu Cys 
    1115                 1120                 1125             


Gln Thr  Ile Ile Ala His Lys  Leu Phe Asp Tyr Val  Val Leu Ala 
    1130                 1135                 1140             


Phe Ile  Phe Leu Asn Cys Ile  Thr Ile Ala Leu Glu  Arg Pro Gln 
    1145                 1150                 1155             


Ile Glu  Ala Gly Ser Thr Glu  Arg Ile Phe Leu Thr  Val Ser Asn 
    1160                 1165                 1170             


Tyr Ile  Phe Thr Ala Ile Phe  Val Gly Glu Met Thr  Leu Lys Val 
    1175                 1180                 1185             


Val Ser  Leu Gly Leu Tyr Phe  Gly Glu Gln Ala Tyr  Leu Arg Ser 
    1190                 1195                 1200             


Ser Trp  Asn Val Leu Asp Gly  Phe Leu Val Phe Val  Ser Ile Ile 
    1205                 1210                 1215             


Asp Ile  Val Val Ser Leu Ala  Ser Ala Gly Gly Ala  Lys Ile Leu 
    1220                 1225                 1230             


Gly Val  Leu Arg Val Leu Arg  Leu Leu Arg Thr Leu  Arg Pro Leu 
    1235                 1240                 1245             


Arg Val  Ile Ser Arg Ala Pro  Gly Leu Lys Leu Val  Val Glu Thr 
    1250                 1255                 1260             


Leu Ile  Ser Ser Leu Lys Pro  Ile Gly Asn Ile Val  Leu Ile Cys 
    1265                 1270                 1275             


Cys Ala  Phe Phe Ile Ile Phe  Gly Ile Leu Gly Val  Gln Leu Phe 
    1280                 1285                 1290             


Lys Gly  Lys Phe Tyr His Cys  Leu Gly Val Asp Thr  Arg Asn Ile 
    1295                 1300                 1305             


Thr Asn  Arg Ser Asp Cys Met  Ala Ala Asn Tyr Arg  Trp Val His 
    1310                 1315                 1320             


His Lys  Tyr Asn Phe Asp Asn  Leu Gly Gln Ala Leu  Met Ser Leu 
    1325                 1330                 1335             


Phe Val  Leu Ala Ser Lys Asp  Gly Trp Val Asn Ile  Met Tyr Asn 
    1340                 1345                 1350             


Gly Leu  Asp Ala Val Ala Val  Asp Gln Gln Pro Val  Thr Asn His 
    1355                 1360                 1365             


Asn Pro  Trp Met Leu Leu Tyr  Phe Ile Ser Phe Leu  Leu Ile Val 
    1370                 1375                 1380             


Ser Phe  Phe Val Leu Asn Met  Phe Val Gly Val Val  Val Glu Asn 
    1385                 1390                 1395             


Phe His  Lys Cys Arg Gln His  Gln Glu Ala Glu Glu  Ala Arg Arg 
    1400                 1405                 1410             


Arg Glu  Glu Lys Arg Leu Arg  Arg Leu Glu Lys Lys  Arg Arg Lys 
    1415                 1420                 1425             


Ala Gln  Arg Leu Pro Tyr Tyr  Ala Thr Tyr Cys His  Thr Arg Leu 
    1430                 1435                 1440             


Leu Ile  His Ser Met Cys Thr  Ser His Tyr Leu Asp  Ile Phe Ile 
    1445                 1450                 1455             


Thr Phe  Ile Ile Cys Leu Asn  Val Val Thr Met Ser  Leu Glu His 
    1460                 1465                 1470             


Tyr Asn  Gln Pro Thr Ser Leu  Glu Thr Ala Leu Lys  Tyr Cys Asn 
    1475                 1480                 1485             


Tyr Met  Phe Thr Thr Val Phe  Val Leu Glu Ala Val  Leu Lys Leu 
    1490                 1495                 1500             


Val Ala  Phe Gly Leu Arg Arg  Phe Phe Lys Asp Arg  Trp Asn Gln 
    1505                 1510                 1515             


Leu Asp  Leu Ala Ile Val Leu  Leu Ser Val Met Gly  Ile Thr Leu 
    1520                 1525                 1530             


Glu Glu  Ile Glu Ile Asn Ala  Ala Leu Pro Ile Asn  Pro Thr Ile 
    1535                 1540                 1545             


Ile Arg  Ile Met Arg Val Leu  Arg Ile Ala Arg Val  Leu Lys Leu 
    1550                 1555                 1560             


Leu Lys  Met Ala Thr Gly Met  Arg Ala Leu Leu Asp  Thr Val Val 
    1565                 1570                 1575             


Gln Ala  Leu Pro Gln Val Gly  Asn Leu Gly Leu Leu  Phe Met Leu 
    1580                 1585                 1590             


Leu Phe  Phe Ile Tyr Ala Ala  Leu Gly Val Glu Leu  Phe Gly Lys 
    1595                 1600                 1605             


Leu Val  Cys Asn Asp Glu Asn  Pro Cys Glu Gly Met  Ser Arg His 
    1610                 1615                 1620             


Ala Thr  Phe Glu Asn Phe Gly  Met Ala Phe Leu Thr  Leu Phe Gln 
    1625                 1630                 1635             


Val Ser  Thr Gly Asp Asn Trp  Asn Gly Ile Met Lys  Asp Thr Leu 
    1640                 1645                 1650             


Arg Asp  Cys Thr His Asp Glu  Arg Ser Cys Leu Ser  Ser Leu Gln 
    1655                 1660                 1665             


Phe Val  Ser Pro Leu Tyr Phe  Val Ser Phe Val Leu  Thr Ala Gln 
    1670                 1675                 1680             


Phe Val  Leu Ile Asn Val Val  Val Ala Val Leu Met  Lys His Leu 
    1685                 1690                 1695             


Asp Asp  Ser Asn Lys Glu Ala  Gln Glu Asp Ala Glu  Met Asp Ala 
    1700                 1705                 1710             


Glu Leu  Glu Leu Glu Met Ala  His Gly Leu Gly Pro  Gly Pro Arg 
    1715                 1720                 1725             


Leu Pro  Thr Gly Ser Pro Gly  Ala Pro Gly Arg Gly  Pro Gly Gly 
    1730                 1735                 1740             


Ala Gly  Gly Gly Gly Asp Thr  Glu Gly Gly Leu Cys  Arg Arg Cys 
    1745                 1750                 1755             


Tyr Ser  Pro Ala Gln Glu Asn  Leu Trp Leu Asp Ser  Val Ser Leu 
    1760                 1765                 1770             


Ile Ile  Lys Asp Ser Leu Glu  Gly Glu Leu Thr Ile  Ile Asp Asn 
    1775                 1780                 1785             


Leu Ser  Gly Ser Ile Phe His  His Tyr Ser Ser Pro  Ala Gly Cys 
    1790                 1795                 1800             


Lys Lys  Cys His His Asp Lys  Gln Glu Val Gln Leu  Ala Glu Thr 
    1805                 1810                 1815             


Glu Ala  Phe Ser Leu Asn Ser  Asp Arg Ser Ser Ser  Ile Leu Leu 
    1820                 1825                 1830             


Gly Asp  Asp Leu Ser Leu Glu  Asp Pro Thr Ala Cys  Pro Pro Gly 
    1835                 1840                 1845             


Arg Lys  Asp Ser Lys Gly Glu  Leu Asp Pro Pro Glu  Pro Met Arg 
    1850                 1855                 1860             


Val Gly  Asp Leu Gly Glu Cys  Phe Phe Pro Leu Ser  Ser Thr Ala 
    1865                 1870                 1875             


Val Ser  Pro Asp Pro Glu Asn  Phe Leu Cys Glu Met  Glu Glu Ile 
    1880                 1885                 1890             


Pro Phe  Asn Pro Val Arg Ser  Trp Leu Lys His Asp  Ser Ser Gln 
    1895                 1900                 1905             


Ala Pro  Pro Ser Pro Phe Ser  Pro Asp Ala Ser Ser  Pro Leu Leu 
    1910                 1915                 1920             


Pro Met  Pro Ala Glu Phe Phe  His Pro Ala Val Ser  Ala Ser Gln 
    1925                 1930                 1935             


Lys Gly  Pro Glu Lys Gly Thr  Gly Thr Gly Thr Leu  Pro Lys Ile 
    1940                 1945                 1950             


Ala Leu  Gln Gly Ser Trp Ala  Ser Leu Arg Ser Pro  Arg Val Asn 
    1955                 1960                 1965             


Cys Thr  Leu Leu Arg Gln Ala  Thr Gly Ser Asp Thr  Ser Leu Asp 
    1970                 1975                 1980             


Ala Ser  Pro Ser Ser Ser Ala  Gly Ser Leu Gln Thr  Thr Leu Glu 
    1985                 1990                 1995             


Asp Ser  Leu Thr Leu Ser Asp  Ser Pro Arg Arg Ala  Leu Gly Pro 
    2000                 2005                 2010             


Pro Ala  Pro Ala Pro Gly Pro  Arg Ala Gly Leu Ser  Pro Ala Ala 
    2015                 2020                 2025             


Arg Arg  Arg Leu Ser Leu Arg  Gly Arg Gly Leu Phe  Ser Leu Arg 
    2030                 2035                 2040             


Gly Leu  Arg Ala His Gln Arg  Ser His Ser Ser Gly  Gly Ser Thr 
    2045                 2050                 2055             


Ser Pro  Gly Cys Thr His His  Asp Ser Met Asp Pro  Ser Asp Glu 
    2060                 2065                 2070             


Glu Gly  Arg Gly Gly Ala Gly  Gly Gly Gly Ala Gly  Ser Glu His 
    2075                 2080                 2085             


Ser Glu  Thr Leu Ser Ser Leu  Ser Leu Thr Ser Leu  Phe Cys Pro 
    2090                 2095                 2100             


Pro Pro  Pro Pro Pro Ala Pro  Gly Leu Thr Pro Ala  Arg Lys Phe 
    2105                 2110                 2115             


Ser Ser  Thr Ser Ser Leu Ala  Ala Pro Gly Arg Pro  His Ala Ala 
    2120                 2125                 2130             


Ala Leu  Ala His Gly Leu Ala  Arg Ser Pro Ser Trp  Ala Ala Asp 
    2135                 2140                 2145             


Arg Ser  Lys Asp Pro Pro Gly  Arg Ala Pro Leu Pro  Met Gly Leu 
    2150                 2155                 2160             


Gly Pro  Leu Ala Pro Pro Pro  Gln Pro Leu Pro Gly  Glu Leu Glu 
    2165                 2170                 2175             


Pro Gly  Asp Ala Ala Ser Lys  Arg Lys Arg 
    2180                 2185             


<210> 21
<211> 495
<212> PRT
<213> Homo sapiens

<400> 21
Met Thr Val Met Ser Gly Glu Asn Val Asp Glu Ala Ser Ala Ala Pro 
1               5                   10                  15      


Gly His Pro Gln Asp Gly Ser Tyr Pro Arg Gln Ala Asp His Asp Asp 
            20                  25                  30          


His Glu Cys Cys Glu Arg Val Val Ile Asn Ile Ser Gly Leu Arg Phe 
        35                  40                  45              


Glu Thr Gln Leu Lys Thr Leu Ala Gln Phe Pro Asn Thr Leu Leu Gly 
    50                  55                  60                  


Asn Pro Lys Lys Arg Met Arg Tyr Phe Asp Pro Leu Arg Asn Glu Tyr 
65                  70                  75                  80  


Phe Phe Asp Arg Asn Arg Pro Ser Phe Asp Ala Ile Leu Tyr Tyr Tyr 
                85                  90                  95      


Gln Ser Gly Gly Arg Leu Arg Arg Pro Val Asn Val Pro Leu Asp Met 
            100                 105                 110         


Phe Ser Glu Glu Ile Lys Phe Tyr Glu Leu Gly Glu Glu Ala Met Glu 
        115                 120                 125             


Lys Phe Arg Glu Asp Glu Gly Phe Ile Lys Glu Glu Glu Arg Pro Leu 
    130                 135                 140                 


Pro Glu Lys Glu Tyr Gln Arg Gln Val Trp Leu Leu Phe Glu Tyr Pro 
145                 150                 155                 160 


Glu Ser Ser Gly Pro Ala Arg Val Ile Ala Ile Val Ser Val Met Val 
                165                 170                 175     


Ile Leu Ile Ser Ile Val Ile Phe Cys Leu Glu Thr Leu Pro Glu Leu 
            180                 185                 190         


Lys Asp Asp Lys Asp Phe Thr Gly Thr Val His Arg Ile Asp Asn Thr 
        195                 200                 205             


Thr Val Ile Tyr Asn Ser Asn Ile Phe Thr Asp Pro Phe Phe Ile Val 
    210                 215                 220                 


Glu Thr Leu Cys Ile Ile Trp Phe Ser Phe Glu Leu Val Val Arg Phe 
225                 230                 235                 240 


Phe Ala Cys Pro Ser Lys Thr Asp Phe Phe Lys Asn Ile Met Asn Phe 
                245                 250                 255     


Ile Asp Ile Val Ala Ile Ile Pro Tyr Phe Ile Thr Leu Gly Thr Glu 
            260                 265                 270         


Ile Ala Glu Gln Glu Gly Asn Gln Lys Gly Glu Gln Ala Thr Ser Leu 
        275                 280                 285             


Ala Ile Leu Arg Val Ile Arg Leu Val Arg Val Phe Arg Ile Phe Lys 
    290                 295                 300                 


Leu Ser Arg His Ser Lys Gly Leu Gln Ile Leu Gly Gln Thr Leu Lys 
305                 310                 315                 320 


Ala Ser Met Arg Glu Leu Gly Leu Leu Ile Phe Phe Leu Phe Ile Gly 
                325                 330                 335     


Val Ile Leu Phe Ser Ser Ala Val Tyr Phe Ala Glu Ala Glu Glu Ala 
            340                 345                 350         


Glu Ser His Phe Ser Ser Ile Pro Asp Ala Phe Trp Trp Ala Val Val 
        355                 360                 365             


Ser Met Thr Thr Val Gly Tyr Gly Asp Met Tyr Pro Val Thr Ile Gly 
    370                 375                 380                 


Gly Lys Ile Val Gly Ser Leu Cys Ala Ile Ala Gly Val Leu Thr Ile 
385                 390                 395                 400 


Ala Leu Pro Val Pro Val Ile Val Ser Asn Phe Asn Tyr Phe Tyr His 
                405                 410                 415     


Arg Glu Thr Glu Gly Glu Glu Gln Ala Gln Leu Leu His Val Ser Ser 
            420                 425                 430         


Pro Asn Leu Ala Ser Asp Ser Asp Leu Ser Arg Arg Ser Ser Ser Thr 
        435                 440                 445             


Met Ser Lys Ser Glu Tyr Met Glu Ile Glu Glu Asp Met Asn Asn Ser 
    450                 455                 460                 


Ile Ala His Tyr Arg Gln Val Asn Ile Arg Thr Ala Asn Cys Thr Thr 
465                 470                 475                 480 


Ala Asn Gln Asn Cys Val Asn Lys Ser Lys Leu Leu Thr Asp Val 
                485                 490                 495 


<210> 22
<211> 499
<212> PRT
<213> Homo sapiens

<400> 22
Met Thr Val Ala Thr Gly Asp Pro Ala Asp Glu Ala Ala Ala Leu Pro 
1               5                   10                  15      


Gly His Pro Gln Asp Thr Tyr Asp Pro Glu Ala Asp His Glu Cys Cys 
            20                  25                  30          


Glu Arg Val Val Ile Asn Ile Ser Gly Leu Arg Phe Glu Thr Gln Leu 
        35                  40                  45              


Lys Thr Leu Ala Gln Phe Pro Glu Thr Leu Leu Gly Asp Pro Lys Lys 
    50                  55                  60                  


Arg Met Arg Tyr Phe Asp Pro Leu Arg Asn Glu Tyr Phe Phe Asp Arg 
65                  70                  75                  80  


Asn Arg Pro Ser Phe Asp Ala Ile Leu Tyr Tyr Tyr Gln Ser Gly Gly 
                85                  90                  95      


Arg Leu Arg Arg Pro Val Asn Val Pro Leu Asp Ile Phe Ser Glu Glu 
            100                 105                 110         


Ile Arg Phe Tyr Glu Leu Gly Glu Glu Ala Met Glu Met Phe Arg Glu 
        115                 120                 125             


Asp Glu Gly Tyr Ile Lys Glu Glu Glu Arg Pro Leu Pro Glu Asn Glu 
    130                 135                 140                 


Phe Gln Arg Gln Val Trp Leu Leu Phe Glu Tyr Pro Glu Ser Ser Gly 
145                 150                 155                 160 


Pro Ala Arg Ile Ile Ala Ile Val Ser Val Met Val Ile Leu Ile Ser 
                165                 170                 175     


Ile Val Ser Phe Cys Leu Glu Thr Leu Pro Ile Phe Arg Asp Glu Asn 
            180                 185                 190         


Glu Asp Met His Gly Ser Gly Val Thr Phe His Thr Tyr Ser Asn Ser 
        195                 200                 205             


Thr Ile Gly Tyr Gln Gln Ser Thr Ser Phe Thr Asp Pro Phe Phe Ile 
    210                 215                 220                 


Val Glu Thr Leu Cys Ile Ile Trp Phe Ser Phe Glu Phe Leu Val Arg 
225                 230                 235                 240 


Phe Phe Ala Cys Pro Ser Lys Ala Gly Phe Phe Thr Asn Ile Met Asn 
                245                 250                 255     


Ile Ile Asp Ile Val Ala Ile Ile Pro Tyr Phe Ile Thr Leu Gly Thr 
            260                 265                 270         


Glu Leu Ala Glu Lys Pro Glu Asp Ala Gln Gln Gly Gln Gln Ala Met 
        275                 280                 285             


Ser Leu Ala Ile Leu Arg Val Ile Arg Leu Val Arg Val Phe Arg Ile 
    290                 295                 300                 


Phe Lys Leu Ser Arg His Ser Lys Gly Leu Gln Ile Leu Gly Gln Thr 
305                 310                 315                 320 


Leu Lys Ala Ser Met Arg Glu Leu Gly Leu Leu Ile Phe Phe Leu Phe 
                325                 330                 335     


Ile Gly Val Ile Leu Phe Ser Ser Ala Val Tyr Phe Ala Glu Ala Asp 
            340                 345                 350         


Glu Arg Glu Ser Gln Phe Pro Ser Ile Pro Asp Ala Phe Trp Trp Ala 
        355                 360                 365             


Val Val Ser Met Thr Thr Val Gly Tyr Gly Asp Met Val Pro Thr Thr 
    370                 375                 380                 


Ile Gly Gly Lys Ile Val Gly Ser Leu Cys Ala Ile Ala Gly Val Leu 
385                 390                 395                 400 


Thr Ile Ala Leu Pro Val Pro Val Ile Val Ser Asn Phe Asn Tyr Phe 
                405                 410                 415     


Tyr His Arg Glu Thr Glu Gly Glu Glu Gln Ala Gln Tyr Leu Gln Val 
            420                 425                 430         


Thr Ser Cys Pro Lys Ile Pro Ser Ser Pro Asp Leu Lys Lys Ser Arg 
        435                 440                 445             


Ser Ala Ser Thr Ile Ser Lys Ser Asp Tyr Met Glu Ile Gln Glu Gly 
    450                 455                 460                 


Val Asn Asn Ser Asn Glu Asp Phe Arg Glu Glu Asn Leu Lys Thr Ala 
465                 470                 475                 480 


Asn Cys Thr Leu Ala Asn Thr Asn Tyr Val Asn Ile Thr Lys Met Leu 
                485                 490                 495     


Thr Asp Val 
            


<210> 23
<211> 575
<212> PRT
<213> Homo sapiens

<400> 23
Met Asp Glu Arg Leu Ser Leu Leu Arg Ser Pro Pro Pro Pro Ser Ala 
1               5                   10                  15      


Arg His Arg Ala His Pro Pro Gln Arg Pro Ala Ser Ser Gly Gly Ala 
            20                  25                  30          


His Thr Leu Val Asn His Gly Tyr Ala Glu Pro Ala Ala Gly Arg Glu 
        35                  40                  45              


Leu Pro Pro Asp Met Thr Val Val Pro Gly Asp His Leu Leu Glu Pro 
    50                  55                  60                  


Glu Val Ala Asp Gly Gly Gly Ala Pro Pro Gln Gly Gly Cys Gly Gly 
65                  70                  75                  80  


Gly Gly Cys Asp Arg Tyr Glu Pro Leu Pro Pro Ser Leu Pro Ala Ala 
                85                  90                  95      


Gly Glu Gln Asp Cys Cys Gly Glu Arg Val Val Ile Asn Ile Ser Gly 
            100                 105                 110         


Leu Arg Phe Glu Thr Gln Leu Lys Thr Leu Cys Gln Phe Pro Glu Thr 
        115                 120                 125             


Leu Leu Gly Asp Pro Lys Arg Arg Met Arg Tyr Phe Asp Pro Leu Arg 
    130                 135                 140                 


Asn Glu Tyr Phe Phe Asp Arg Asn Arg Pro Ser Phe Asp Ala Ile Leu 
145                 150                 155                 160 


Tyr Tyr Tyr Gln Ser Gly Gly Arg Ile Arg Arg Pro Val Asn Val Pro 
                165                 170                 175     


Ile Asp Ile Phe Ser Glu Glu Ile Arg Phe Tyr Gln Leu Gly Glu Glu 
            180                 185                 190         


Ala Met Glu Lys Phe Arg Glu Asp Glu Gly Phe Leu Arg Glu Glu Glu 
        195                 200                 205             


Arg Pro Leu Pro Arg Arg Asp Phe Gln Arg Gln Val Trp Leu Leu Phe 
    210                 215                 220                 


Glu Tyr Pro Glu Ser Ser Gly Pro Ala Arg Gly Ile Ala Ile Val Ser 
225                 230                 235                 240 


Val Leu Val Ile Leu Ile Ser Ile Val Ile Phe Cys Leu Glu Thr Leu 
                245                 250                 255     


Pro Glu Phe Arg Asp Glu Lys Asp Tyr Pro Ala Ser Thr Ser Gln Asp 
            260                 265                 270         


Ser Phe Glu Ala Ala Gly Asn Ser Thr Ser Gly Ser Arg Ala Gly Ala 
        275                 280                 285             


Ser Ser Phe Ser Asp Pro Phe Phe Val Val Glu Thr Leu Cys Ile Ile 
    290                 295                 300                 


Trp Phe Ser Phe Glu Leu Leu Val Arg Phe Phe Ala Cys Pro Ser Lys 
305                 310                 315                 320 


Ala Thr Phe Ser Arg Asn Ile Met Asn Leu Ile Asp Ile Val Ala Ile 
                325                 330                 335     


Ile Pro Tyr Phe Ile Thr Leu Gly Thr Glu Leu Ala Glu Arg Gln Gly 
            340                 345                 350         


Asn Gly Gln Gln Ala Met Ser Leu Ala Ile Leu Arg Val Ile Arg Leu 
        355                 360                 365             


Val Arg Val Phe Arg Ile Phe Lys Leu Ser Arg His Ser Lys Gly Leu 
    370                 375                 380                 


Gln Ile Leu Gly Gln Thr Leu Lys Ala Ser Met Arg Glu Leu Gly Leu 
385                 390                 395                 400 


Leu Ile Phe Phe Leu Phe Ile Gly Val Ile Leu Phe Ser Ser Ala Val 
                405                 410                 415     


Tyr Phe Ala Glu Ala Asp Asp Pro Thr Ser Gly Phe Ser Ser Ile Pro 
            420                 425                 430         


Asp Ala Phe Trp Trp Ala Val Val Thr Met Thr Thr Val Gly Tyr Gly 
        435                 440                 445             


Asp Met His Pro Val Thr Ile Gly Gly Lys Ile Val Gly Ser Leu Cys 
    450                 455                 460                 


Ala Ile Ala Gly Val Leu Thr Ile Ala Leu Pro Val Pro Val Ile Val 
465                 470                 475                 480 


Ser Asn Phe Asn Tyr Phe Tyr His Arg Glu Thr Glu Gly Glu Glu Gln 
                485                 490                 495     


Ser Gln Tyr Met His Val Gly Ser Cys Gln His Leu Ser Ser Ser Ala 
            500                 505                 510         


Glu Glu Leu Arg Lys Ala Arg Ser Asn Ser Thr Leu Ser Lys Ser Glu 
        515                 520                 525             


Tyr Met Val Ile Glu Glu Gly Gly Met Asn His Ser Ala Phe Pro Gln 
    530                 535                 540                 


Thr Pro Phe Lys Thr Gly Asn Ser Thr Ala Thr Cys Thr Thr Asn Asn 
545                 550                 555                 560 


Asn Pro Asn Ser Cys Val Asn Ile Lys Lys Ile Phe Thr Asp Val 
                565                 570                 575 


<210> 24
<211> 653
<212> PRT
<213> Homo sapiens

<400> 24
Met Glu Val Ala Met Val Ser Ala Glu Ser Ser Gly Cys Asn Ser His 
1               5                   10                  15      


Met Pro Tyr Gly Tyr Ala Ala Gln Ala Arg Ala Arg Glu Arg Glu Arg 
            20                  25                  30          


Leu Ala His Ser Arg Ala Ala Ala Ala Ala Ala Val Ala Ala Ala Thr 
        35                  40                  45              


Ala Ala Val Glu Gly Ser Gly Gly Ser Gly Gly Gly Ser His His His 
    50                  55                  60                  


His Gln Ser Arg Gly Ala Cys Thr Ser His Asp Pro Gln Ser Ser Arg 
65                  70                  75                  80  


Gly Ser Arg Arg Arg Arg Arg Gln Arg Ser Glu Lys Lys Lys Ala His 
                85                  90                  95      


Tyr Arg Gln Ser Ser Phe Pro His Cys Ser Asp Leu Met Pro Ser Gly 
            100                 105                 110         


Ser Glu Glu Lys Ile Leu Arg Glu Leu Ser Glu Glu Glu Glu Asp Glu 
        115                 120                 125             


Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Arg Phe Tyr Tyr Ser Glu 
    130                 135                 140                 


Asp Asp His Gly Asp Glu Cys Ser Tyr Thr Asp Leu Leu Pro Gln Asp 
145                 150                 155                 160 


Glu Gly Gly Gly Gly Tyr Ser Ser Val Arg Tyr Ser Asp Cys Cys Glu 
                165                 170                 175     


Arg Val Val Ile Asn Val Ser Gly Leu Arg Phe Glu Thr Gln Met Lys 
            180                 185                 190         


Thr Leu Ala Gln Phe Pro Glu Thr Leu Leu Gly Asp Pro Glu Lys Arg 
        195                 200                 205             


Thr Gln Tyr Phe Asp Pro Leu Arg Asn Glu Tyr Phe Phe Asp Arg Asn 
    210                 215                 220                 


Arg Pro Ser Phe Asp Ala Ile Leu Tyr Tyr Tyr Gln Ser Gly Gly Arg 
225                 230                 235                 240 


Leu Lys Arg Pro Val Asn Val Pro Phe Asp Ile Phe Thr Glu Glu Val 
                245                 250                 255     


Lys Phe Tyr Gln Leu Gly Glu Glu Ala Leu Leu Lys Phe Arg Glu Asp 
            260                 265                 270         


Glu Gly Phe Val Arg Glu Glu Glu Asp Arg Ala Leu Pro Glu Asn Glu 
        275                 280                 285             


Phe Lys Lys Gln Ile Trp Leu Leu Phe Glu Tyr Pro Glu Ser Ser Ser 
    290                 295                 300                 


Pro Ala Arg Gly Ile Ala Ile Val Ser Val Leu Val Ile Leu Ile Ser 
305                 310                 315                 320 


Ile Val Ile Phe Cys Leu Glu Thr Leu Pro Glu Phe Arg Asp Asp Arg 
                325                 330                 335     


Asp Leu Val Met Ala Leu Ser Ala Gly Gly His Gly Gly Leu Leu Asn 
            340                 345                 350         


Asp Thr Ser Ala Pro His Leu Glu Asn Ser Gly His Thr Ile Phe Asn 
        355                 360                 365             


Asp Pro Phe Phe Ile Val Glu Thr Val Cys Ile Val Trp Phe Ser Phe 
    370                 375                 380                 


Glu Phe Val Val Arg Cys Phe Ala Cys Pro Ser Gln Ala Leu Phe Phe 
385                 390                 395                 400 


Lys Asn Ile Met Asn Ile Ile Asp Ile Val Ser Ile Leu Pro Tyr Phe 
                405                 410                 415     


Ile Thr Leu Gly Thr Asp Leu Ala Gln Gln Gln Gly Gly Gly Asn Gly 
            420                 425                 430         


Gln Gln Gln Gln Ala Met Ser Phe Ala Ile Leu Arg Ile Ile Arg Leu 
        435                 440                 445             


Val Arg Val Phe Arg Ile Phe Lys Leu Ser Arg His Ser Lys Gly Leu 
    450                 455                 460                 


Gln Ile Leu Gly His Thr Leu Arg Ala Ser Met Arg Glu Leu Gly Leu 
465                 470                 475                 480 


Leu Ile Phe Phe Leu Phe Ile Gly Val Ile Leu Phe Ser Ser Ala Val 
                485                 490                 495     


Tyr Phe Ala Glu Ala Asp Glu Pro Thr Thr His Phe Gln Ser Ile Pro 
            500                 505                 510         


Asp Ala Phe Trp Trp Ala Val Val Thr Met Thr Thr Val Gly Tyr Gly 
        515                 520                 525             


Asp Met Lys Pro Ile Thr Val Gly Gly Lys Ile Val Gly Ser Leu Cys 
    530                 535                 540                 


Ala Ile Ala Gly Val Leu Thr Ile Ala Leu Pro Val Pro Val Ile Val 
545                 550                 555                 560 


Ser Asn Phe Asn Tyr Phe Tyr His Arg Glu Thr Glu Asn Glu Glu Gln 
                565                 570                 575     


Thr Gln Leu Thr Gln Asn Ala Val Ser Cys Pro Tyr Leu Pro Ser Asn 
            580                 585                 590         


Leu Leu Lys Lys Phe Arg Ser Ser Thr Ser Ser Ser Leu Gly Asp Lys 
        595                 600                 605             


Ser Glu Tyr Leu Glu Met Glu Glu Gly Val Lys Glu Ser Leu Cys Ala 
    610                 615                 620                 


Lys Glu Glu Lys Cys Gln Gly Lys Gly Asp Asp Ser Glu Thr Asp Lys 
625                 630                 635                 640 


Asn Asn Cys Ser Asn Ala Lys Ala Val Glu Thr Asp Val 
                645                 650             


<210> 25
<211> 613
<212> PRT
<213> Homo sapiens

<400> 25
Met Glu Ile Ala Leu Val Pro Leu Glu Asn Gly Gly Ala Met Thr Val 
1               5                   10                  15      


Arg Gly Gly Asp Glu Ala Arg Ala Gly Cys Gly Gln Ala Thr Gly Gly 
            20                  25                  30          


Glu Leu Gln Cys Pro Pro Thr Ala Gly Leu Ser Asp Gly Pro Lys Glu 
        35                  40                  45              


Pro Ala Pro Lys Gly Arg Gly Ala Gln Arg Asp Ala Asp Ser Gly Val 
    50                  55                  60                  


Arg Pro Leu Pro Pro Leu Pro Asp Pro Gly Val Arg Pro Leu Pro Pro 
65                  70                  75                  80  


Leu Pro Glu Glu Leu Pro Arg Pro Arg Arg Pro Pro Pro Glu Asp Glu 
                85                  90                  95      


Glu Glu Glu Gly Asp Pro Gly Leu Gly Thr Val Glu Asp Gln Ala Leu 
            100                 105                 110         


Gly Thr Ala Ser Leu His His Gln Arg Val His Ile Asn Ile Ser Gly 
        115                 120                 125             


Leu Arg Phe Glu Thr Gln Leu Gly Thr Leu Ala Gln Phe Pro Asn Thr 
    130                 135                 140                 


Leu Leu Gly Asp Pro Ala Lys Arg Leu Arg Tyr Phe Asp Pro Leu Arg 
145                 150                 155                 160 


Asn Glu Tyr Phe Phe Asp Arg Asn Arg Pro Ser Phe Asp Gly Ile Leu 
                165                 170                 175     


Tyr Tyr Tyr Gln Ser Gly Gly Arg Leu Arg Arg Pro Val Asn Val Ser 
            180                 185                 190         


Leu Asp Val Phe Ala Asp Glu Ile Arg Phe Tyr Gln Leu Gly Asp Glu 
        195                 200                 205             


Ala Met Glu Arg Phe Arg Glu Asp Glu Gly Phe Ile Lys Glu Glu Glu 
    210                 215                 220                 


Lys Pro Leu Pro Arg Asn Glu Phe Gln Arg Gln Val Trp Leu Ile Phe 
225                 230                 235                 240 


Glu Tyr Pro Glu Ser Ser Gly Ser Ala Arg Ala Ile Ala Ile Val Ser 
                245                 250                 255     


Val Leu Val Ile Leu Ile Ser Ile Ile Thr Phe Cys Leu Glu Thr Leu 
            260                 265                 270         


Pro Glu Phe Arg Asp Glu Arg Glu Leu Leu Arg His Pro Pro Ala Pro 
        275                 280                 285             


His Gln Pro Pro Ala Pro Ala Pro Gly Ala Asn Gly Ser Gly Val Met 
    290                 295                 300                 


Ala Pro Pro Ser Gly Pro Thr Val Ala Pro Leu Leu Pro Arg Thr Leu 
305                 310                 315                 320 


Ala Asp Pro Phe Phe Ile Val Glu Thr Thr Cys Val Ile Trp Phe Thr 
                325                 330                 335     


Phe Glu Leu Leu Val Arg Phe Phe Ala Cys Pro Ser Lys Ala Gly Phe 
            340                 345                 350         


Ser Arg Asn Ile Met Asn Ile Ile Asp Val Val Ala Ile Phe Pro Tyr 
        355                 360                 365             


Phe Ile Thr Leu Gly Thr Glu Leu Ala Glu Gln Gln Pro Gly Gly Gly 
    370                 375                 380                 


Gly Gly Gly Gln Asn Gly Gln Gln Ala Met Ser Leu Ala Ile Leu Arg 
385                 390                 395                 400 


Val Ile Arg Leu Val Arg Val Phe Arg Ile Phe Lys Leu Ser Arg His 
                405                 410                 415     


Ser Lys Gly Leu Gln Ile Leu Gly Lys Thr Leu Gln Ala Ser Met Arg 
            420                 425                 430         


Glu Leu Gly Leu Leu Ile Phe Phe Leu Phe Ile Gly Val Ile Leu Phe 
        435                 440                 445             


Ser Ser Ala Val Tyr Phe Ala Glu Ala Asp Asn Gln Gly Thr His Phe 
    450                 455                 460                 


Ser Ser Ile Pro Asp Ala Phe Trp Trp Ala Val Val Thr Met Thr Thr 
465                 470                 475                 480 


Val Gly Tyr Gly Asp Met Arg Pro Ile Thr Val Gly Gly Lys Ile Val 
                485                 490                 495     


Gly Ser Leu Cys Ala Ile Ala Gly Val Leu Thr Ile Ala Leu Pro Val 
            500                 505                 510         


Pro Val Ile Val Ser Asn Phe Asn Tyr Phe Tyr His Arg Glu Thr Asp 
        515                 520                 525             


His Glu Glu Pro Ala Val Leu Lys Glu Glu Gln Gly Thr Gln Ser Gln 
    530                 535                 540                 


Gly Pro Gly Leu Asp Arg Gly Val Gln Arg Lys Val Ser Gly Ser Arg 
545                 550                 555                 560 


Gly Ser Phe Cys Lys Ala Gly Gly Thr Leu Glu Asn Ala Asp Ser Ala 
                565                 570                 575     


Arg Arg Gly Ser Cys Pro Leu Glu Lys Cys Asn Val Lys Ala Lys Ser 
            580                 585                 590         


Asn Val Asp Leu Arg Arg Ser Leu Tyr Ala Leu Cys Leu Asp Thr Ser 
        595                 600                 605             


Arg Glu Thr Asp Leu 
    610             


<210> 26
<211> 529
<212> PRT
<213> Homo sapiens

<400> 26
Met Arg Ser Glu Lys Ser Leu Thr Leu Ala Ala Pro Gly Glu Val Arg 
1               5                   10                  15      


Gly Pro Glu Gly Glu Gln Gln Asp Ala Gly Asp Phe Pro Glu Ala Gly 
            20                  25                  30          


Gly Gly Gly Gly Cys Cys Ser Ser Glu Arg Leu Val Ile Asn Ile Ser 
        35                  40                  45              


Gly Leu Arg Phe Glu Thr Gln Leu Arg Thr Leu Ser Leu Phe Pro Asp 
    50                  55                  60                  


Thr Leu Leu Gly Asp Pro Gly Arg Arg Val Arg Phe Phe Asp Pro Leu 
65                  70                  75                  80  


Arg Asn Glu Tyr Phe Phe Asp Arg Asn Arg Pro Ser Phe Asp Ala Ile 
                85                  90                  95      


Leu Tyr Tyr Tyr Gln Ser Gly Gly Arg Leu Arg Arg Pro Val Asn Val 
            100                 105                 110         


Pro Leu Asp Ile Phe Leu Glu Glu Ile Arg Phe Tyr Gln Leu Gly Asp 
        115                 120                 125             


Glu Ala Leu Ala Ala Phe Arg Glu Asp Glu Gly Cys Leu Pro Glu Gly 
    130                 135                 140                 


Gly Glu Asp Glu Lys Pro Leu Pro Ser Gln Pro Phe Gln Arg Gln Val 
145                 150                 155                 160 


Trp Leu Leu Phe Glu Tyr Pro Glu Ser Ser Gly Pro Ala Arg Gly Ile 
                165                 170                 175     


Ala Ile Val Ser Val Leu Val Ile Leu Ile Ser Ile Val Ile Phe Cys 
            180                 185                 190         


Leu Glu Thr Leu Pro Gln Phe Arg Val Asp Gly Arg Gly Gly Asn Asn 
        195                 200                 205             


Gly Gly Val Ser Arg Val Ser Pro Val Ser Arg Gly Ser Gln Glu Glu 
    210                 215                 220                 


Glu Glu Asp Glu Asp Asp Ser Tyr Thr Phe His His Gly Ile Thr Pro 
225                 230                 235                 240 


Gly Glu Met Gly Thr Gly Gly Ser Ser Ser Leu Ser Thr Leu Gly Gly 
                245                 250                 255     


Ser Phe Phe Thr Asp Pro Phe Phe Leu Val Glu Thr Leu Cys Ile Val 
            260                 265                 270         


Trp Phe Thr Phe Glu Leu Leu Val Arg Phe Ser Ala Cys Pro Ser Lys 
        275                 280                 285             


Pro Ala Phe Phe Arg Asn Ile Met Asn Ile Ile Asp Leu Val Ala Ile 
    290                 295                 300                 


Phe Pro Tyr Phe Ile Thr Leu Gly Thr Glu Leu Val Gln Gln Gln Glu 
305                 310                 315                 320 


Gln Gln Pro Ala Ser Gly Gly Gly Gly Gln Asn Gly Gln Gln Ala Met 
                325                 330                 335     


Ser Leu Ala Ile Leu Arg Val Ile Arg Leu Val Arg Val Phe Arg Ile 
            340                 345                 350         


Phe Lys Leu Ser Arg His Ser Lys Gly Leu Gln Ile Leu Gly Lys Thr 
        355                 360                 365             


Leu Gln Ala Ser Met Arg Glu Leu Gly Leu Leu Ile Phe Phe Leu Phe 
    370                 375                 380                 


Ile Gly Val Ile Leu Phe Ser Ser Ala Val Tyr Phe Ala Glu Ala Asp 
385                 390                 395                 400 


Asp Asp Asp Ser Leu Phe Pro Ser Ile Pro Asp Ala Phe Trp Trp Ala 
                405                 410                 415     


Val Val Thr Met Thr Thr Val Gly Tyr Gly Asp Met Tyr Pro Met Thr 
            420                 425                 430         


Val Gly Gly Lys Ile Val Gly Ser Leu Cys Ala Ile Ala Gly Val Leu 
        435                 440                 445             


Thr Ile Ala Leu Pro Val Pro Val Ile Val Ser Asn Phe Asn Tyr Phe 
    450                 455                 460                 


Tyr His Arg Glu Thr Glu Gln Glu Glu Gln Gly Gln Tyr Thr His Val 
465                 470                 475                 480 


Thr Cys Gly Gln Pro Ala Pro Asp Leu Arg Ala Thr Asp Asn Gly Leu 
                485                 490                 495     


Gly Lys Pro Asp Phe Pro Glu Ala Asn Arg Glu Arg Arg Pro Ser Tyr 
            500                 505                 510         


Leu Pro Thr Pro His Arg Ala Tyr Ala Glu Lys Arg Met Leu Thr Glu 
        515                 520                 525             


Val 
    


<210> 27
<211> 456
<212> PRT
<213> Homo sapiens

<400> 27
Met Glu Pro Arg Cys Pro Pro Pro Cys Gly Cys Cys Glu Arg Leu Val 
1               5                   10                  15      


Leu Asn Val Ala Gly Leu Arg Phe Glu Thr Arg Ala Arg Thr Leu Gly 
            20                  25                  30          


Arg Phe Pro Asp Thr Leu Leu Gly Asp Pro Ala Arg Arg Gly Arg Phe 
        35                  40                  45              


Tyr Asp Asp Ala Arg Arg Glu Tyr Phe Phe Asp Arg His Arg Pro Ser 
    50                  55                  60                  


Phe Asp Ala Val Leu Tyr Tyr Tyr Gln Ser Gly Gly Arg Leu Arg Arg 
65                  70                  75                  80  


Pro Ala His Val Pro Leu Asp Val Phe Leu Glu Glu Val Ala Phe Tyr 
                85                  90                  95      


Gly Leu Gly Ala Ala Ala Leu Ala Arg Leu Arg Glu Asp Glu Gly Cys 
            100                 105                 110         


Pro Val Pro Pro Glu Arg Pro Leu Pro Arg Arg Ala Phe Ala Arg Gln 
        115                 120                 125             


Leu Trp Leu Leu Phe Glu Phe Pro Glu Ser Ser Gln Ala Ala Arg Val 
    130                 135                 140                 


Leu Ala Val Val Ser Val Leu Val Ile Leu Val Ser Ile Val Val Phe 
145                 150                 155                 160 


Cys Leu Glu Thr Leu Pro Asp Phe Arg Asp Asp Arg Asp Gly Thr Gly 
                165                 170                 175     


Leu Ala Ala Ala Ala Ala Ala Gly Pro Phe Pro Ala Pro Leu Asn Gly 
            180                 185                 190         


Ser Ser Gln Met Pro Gly Asn Pro Pro Arg Leu Pro Phe Asn Asp Pro 
        195                 200                 205             


Phe Phe Val Val Glu Thr Leu Cys Ile Cys Trp Phe Ser Phe Glu Leu 
    210                 215                 220                 


Leu Val Arg Leu Leu Val Cys Pro Ser Lys Ala Ile Phe Phe Lys Asn 
225                 230                 235                 240 


Val Met Asn Leu Ile Asp Phe Val Ala Ile Leu Pro Tyr Phe Val Ala 
                245                 250                 255     


Leu Gly Thr Glu Leu Ala Arg Gln Arg Gly Val Gly Gln Gln Ala Met 
            260                 265                 270         


Ser Leu Ala Ile Leu Arg Val Ile Arg Leu Val Arg Val Phe Arg Ile 
        275                 280                 285             


Phe Lys Leu Ser Arg His Ser Lys Gly Leu Gln Ile Leu Gly Gln Thr 
    290                 295                 300                 


Leu Arg Ala Ser Met Arg Glu Leu Gly Leu Leu Ile Phe Phe Leu Phe 
305                 310                 315                 320 


Ile Gly Val Val Leu Phe Ser Ser Ala Val Tyr Phe Ala Glu Val Asp 
                325                 330                 335     


Arg Val Asp Ser His Phe Thr Ser Ile Pro Glu Ser Phe Trp Trp Ala 
            340                 345                 350         


Val Val Thr Met Thr Thr Val Gly Tyr Gly Asp Met Ala Pro Val Thr 
        355                 360                 365             


Val Gly Gly Lys Ile Val Gly Ser Leu Cys Ala Ile Ala Gly Val Leu 
    370                 375                 380                 


Thr Ile Ser Leu Pro Val Pro Val Ile Val Ser Asn Phe Ser Tyr Phe 
385                 390                 395                 400 


Tyr His Arg Glu Thr Glu Gly Glu Glu Ala Gly Met Phe Ser His Val 
                405                 410                 415     


Asp Met Gln Pro Cys Gly Pro Leu Glu Gly Lys Ala Asn Gly Gly Leu 
            420                 425                 430         


Val Asp Gly Glu Val Pro Glu Leu Pro Pro Pro Leu Trp Ala Pro Pro 
        435                 440                 445             


Gly Lys His Leu Val Thr Glu Val 
    450                 455     


<210> 28
<211> 511
<212> PRT
<213> Homo sapiens

<400> 28
Met Asp Val Cys Gly Trp Lys Glu Met Glu Val Ala Leu Val Asn Phe 
1               5                   10                  15      


Asp Asn Ser Asp Glu Ile Gln Glu Glu Pro Gly Tyr Ala Thr Asp Phe 
            20                  25                  30          


Asp Ser Thr Ser Pro Lys Gly Arg Pro Gly Gly Ser Ser Phe Ser Asn 
        35                  40                  45              


Gly Lys Ile Leu Ile Ser Glu Ser Thr Asn His Glu Thr Ala Phe Ser 
    50                  55                  60                  


Lys Leu Pro Gly Asp Tyr Ala Asp Pro Pro Gly Pro Glu Pro Val Val 
65                  70                  75                  80  


Leu Asn Glu Gly Asn Gln Arg Val Ile Ile Asn Ile Ala Gly Leu Arg 
                85                  90                  95      


Phe Glu Thr Gln Leu Arg Thr Leu Ser Gln Phe Pro Glu Thr Leu Leu 
            100                 105                 110         


Gly Asp Arg Glu Lys Arg Met Gln Phe Phe Asp Ser Met Arg Asn Glu 
        115                 120                 125             


Tyr Phe Phe Asp Arg Asn Arg Pro Ser Phe Asp Gly Ile Leu Tyr Tyr 
    130                 135                 140                 


Tyr Gln Ser Gly Gly Lys Ile Arg Arg Pro Ala Asn Val Pro Ile Asp 
145                 150                 155                 160 


Ile Phe Ala Asp Glu Ile Ser Phe Tyr Glu Leu Gly Ser Glu Ala Met 
                165                 170                 175     


Asp Gln Phe Arg Glu Asp Glu Gly Phe Ile Lys Asp Pro Glu Thr Leu 
            180                 185                 190         


Leu Pro Thr Asn Asp Ile His Arg Gln Phe Trp Leu Leu Phe Glu Tyr 
        195                 200                 205             


Pro Glu Ser Ser Ser Ala Ala Arg Ala Val Ala Val Val Ser Val Leu 
    210                 215                 220                 


Val Val Val Ile Ser Ile Thr Ile Phe Cys Leu Glu Thr Leu Pro Glu 
225                 230                 235                 240 


Phe Arg Glu Asp Arg Glu Leu Lys Val Val Arg Asp Pro Asn Leu Asn 
                245                 250                 255     


Met Ser Lys Thr Val Leu Ser Gln Thr Met Phe Thr Asp Pro Phe Phe 
            260                 265                 270         


Met Val Glu Ser Thr Cys Ile Val Trp Phe Thr Phe Glu Leu Val Leu 
        275                 280                 285             


Arg Phe Val Val Cys Pro Ser Lys Thr Asp Phe Phe Arg Asn Ile Met 
    290                 295                 300                 


Asn Ile Ile Asp Ile Ile Ser Ile Ile Pro Tyr Phe Ala Thr Leu Ile 
305                 310                 315                 320 


Thr Glu Leu Val Gln Glu Thr Glu Pro Ser Ala Gln Gln Asn Met Ser 
                325                 330                 335     


Leu Ala Ile Leu Arg Ile Ile Arg Leu Val Arg Val Phe Arg Ile Phe 
            340                 345                 350         


Lys Leu Ser Arg His Ser Lys Gly Leu Gln Ile Leu Gly Gln Thr Leu 
        355                 360                 365             


Lys Ala Ser Met Arg Glu Leu Gly Leu Leu Ile Phe Phe Leu Phe Ile 
    370                 375                 380                 


Gly Val Ile Leu Phe Ser Ser Ala Val Tyr Phe Ala Glu Val Asp Glu 
385                 390                 395                 400 


Pro Glu Ser His Phe Ser Ser Ile Pro Asp Gly Phe Trp Trp Ala Val 
                405                 410                 415     


Val Thr Met Thr Thr Val Gly Tyr Gly Asp Met Cys Pro Thr Thr Pro 
            420                 425                 430         


Gly Gly Lys Ile Val Gly Thr Leu Cys Ala Ile Ala Gly Val Leu Thr 
        435                 440                 445             


Ile Ala Leu Pro Val Pro Val Ile Val Ser Asn Phe Asn Tyr Phe Tyr 
    450                 455                 460                 


His Arg Glu Thr Glu Asn Glu Glu Lys Gln Asn Ile Pro Gly Glu Ile 
465                 470                 475                 480 


Glu Arg Ile Leu Asn Ser Val Gly Ser Arg Met Gly Ser Thr Asp Ser 
                485                 490                 495     


Leu Asn Lys Thr Asn Gly Gly Cys Ser Thr Glu Lys Ser Arg Lys 
            500                 505                 510     


<210> 29
<211> 858
<212> PRT
<213> Homo sapiens

<400> 29
Met Pro Ala Gly Met Thr Lys His Gly Ser Arg Ser Thr Ser Ser Leu 
1               5                   10                  15      


Pro Pro Glu Pro Met Glu Ile Val Arg Ser Lys Ala Cys Ser Arg Arg 
            20                  25                  30          


Val Arg Leu Asn Val Gly Gly Leu Ala His Glu Val Leu Trp Arg Thr 
        35                  40                  45              


Leu Asp Arg Leu Pro Arg Thr Arg Leu Gly Lys Leu Arg Asp Cys Asn 
    50                  55                  60                  


Thr His Asp Ser Leu Leu Glu Val Cys Asp Asp Tyr Ser Leu Asp Asp 
65                  70                  75                  80  


Asn Glu Tyr Phe Phe Asp Arg His Pro Gly Ala Phe Thr Ser Ile Leu 
                85                  90                  95      


Asn Phe Tyr Arg Thr Gly Arg Leu His Met Met Glu Glu Met Cys Ala 
            100                 105                 110         


Leu Ser Phe Ser Gln Glu Leu Asp Tyr Trp Gly Ile Asp Glu Ile Tyr 
        115                 120                 125             


Leu Glu Ser Cys Cys Gln Ala Arg Tyr His Gln Lys Lys Glu Gln Met 
    130                 135                 140                 


Asn Glu Glu Leu Lys Arg Glu Ala Glu Thr Leu Arg Glu Arg Glu Gly 
145                 150                 155                 160 


Glu Glu Phe Asp Asn Thr Cys Cys Ala Glu Lys Arg Lys Lys Leu Trp 
                165                 170                 175     


Asp Leu Leu Glu Lys Pro Asn Ser Ser Val Ala Ala Lys Ile Leu Ala 
            180                 185                 190         


Ile Ile Ser Ile Met Phe Ile Val Leu Ser Thr Ile Ala Leu Ser Leu 
        195                 200                 205             


Asn Thr Leu Pro Glu Leu Gln Ser Leu Asp Glu Phe Gly Gln Ser Thr 
    210                 215                 220                 


Asp Asn Pro Gln Leu Ala His Val Glu Ala Val Cys Ile Ala Trp Phe 
225                 230                 235                 240 


Thr Met Glu Tyr Leu Leu Arg Phe Leu Ser Ser Pro Lys Lys Trp Lys 
                245                 250                 255     


Phe Phe Lys Gly Pro Leu Asn Ala Ile Asp Leu Leu Ala Ile Leu Pro 
            260                 265                 270         


Tyr Tyr Val Thr Ile Phe Leu Thr Glu Ser Asn Lys Ser Val Leu Gln 
        275                 280                 285             


Phe Gln Asn Val Arg Arg Val Val Gln Ile Phe Arg Ile Met Arg Ile 
    290                 295                 300                 


Leu Arg Ile Leu Lys Leu Ala Arg His Ser Thr Gly Leu Gln Ser Leu 
305                 310                 315                 320 


Gly Phe Thr Leu Arg Arg Ser Tyr Asn Glu Leu Gly Leu Leu Ile Leu 
                325                 330                 335     


Phe Leu Ala Met Gly Ile Met Ile Phe Ser Ser Leu Val Phe Phe Ala 
            340                 345                 350         


Glu Lys Asp Glu Asp Asp Thr Lys Phe Lys Ser Ile Pro Ala Ser Phe 
        355                 360                 365             


Trp Trp Ala Thr Ile Thr Met Thr Thr Val Gly Tyr Gly Asp Ile Tyr 
    370                 375                 380                 


Pro Lys Thr Leu Leu Gly Lys Ile Val Gly Gly Leu Cys Cys Ile Ala 
385                 390                 395                 400 


Gly Val Leu Val Ile Ala Leu Pro Ile Pro Ile Ile Val Asn Asn Phe 
                405                 410                 415     


Ser Glu Phe Tyr Lys Glu Gln Lys Arg Gln Glu Lys Ala Ile Lys Arg 
            420                 425                 430         


Arg Glu Ala Leu Glu Arg Ala Lys Arg Asn Gly Ser Ile Val Ser Met 
        435                 440                 445             


Asn Met Lys Asp Ala Phe Ala Arg Ser Ile Glu Met Met Asp Ile Val 
    450                 455                 460                 


Val Glu Lys Asn Gly Glu Asn Met Gly Lys Lys Asp Lys Val Gln Asp 
465                 470                 475                 480 


Asn His Leu Ser Pro Asn Lys Trp Lys Trp Thr Lys Arg Thr Leu Ser 
                485                 490                 495     


Glu Thr Ser Ser Ser Lys Ser Phe Glu Thr Lys Glu Gln Gly Ser Pro 
            500                 505                 510         


Glu Lys Ala Arg Ser Ser Ser Ser Pro Gln His Leu Asn Val Gln Gln 
        515                 520                 525             


Leu Glu Asp Met Tyr Asn Lys Met Ala Lys Thr Gln Ser Gln Pro Ile 
    530                 535                 540                 


Leu Asn Thr Lys Glu Ser Ala Ala Gln Ser Lys Pro Lys Glu Glu Leu 
545                 550                 555                 560 


Glu Met Glu Ser Ile Pro Ser Pro Val Ala Pro Leu Pro Thr Arg Thr 
                565                 570                 575     


Glu Gly Val Ile Asp Met Arg Ser Met Ser Ser Ile Asp Ser Phe Ile 
            580                 585                 590         


Ser Cys Ala Thr Asp Phe Pro Glu Ala Thr Arg Phe Ser His Ser Pro 
        595                 600                 605             


Leu Thr Ser Leu Pro Ser Lys Thr Gly Gly Ser Thr Ala Pro Glu Val 
    610                 615                 620                 


Gly Trp Arg Gly Ala Leu Gly Ala Ser Gly Gly Arg Phe Val Glu Ala 
625                 630                 635                 640 


Asn Pro Ser Pro Asp Ala Ser Gln His Ser Ser Phe Phe Ile Glu Ser 
                645                 650                 655     


Pro Lys Ser Ser Met Lys Thr Asn Asn Pro Leu Lys Leu Arg Ala Leu 
            660                 665                 670         


Lys Val Asn Phe Met Glu Gly Asp Pro Ser Pro Leu Leu Pro Val Leu 
        675                 680                 685             


Gly Met Tyr His Asp Pro Leu Arg Asn Arg Gly Ser Ala Ala Ala Ala 
    690                 695                 700                 


Val Ala Gly Leu Glu Cys Ala Thr Leu Leu Asp Lys Ala Val Leu Ser 
705                 710                 715                 720 


Pro Glu Ser Ser Ile Tyr Thr Thr Ala Ser Ala Lys Thr Pro Pro Arg 
                725                 730                 735     


Ser Pro Glu Lys His Thr Ala Ile Ala Phe Asn Phe Glu Ala Gly Val 
            740                 745                 750         


His Gln Tyr Ile Asp Ala Asp Thr Asp Asp Glu Gly Gln Leu Leu Tyr 
        755                 760                 765             


Ser Val Asp Ser Ser Pro Pro Lys Ser Leu Pro Gly Ser Thr Ser Pro 
    770                 775                 780                 


Lys Phe Ser Thr Gly Thr Arg Ser Glu Lys Asn His Phe Glu Ser Ser 
785                 790                 795                 800 


Pro Leu Pro Thr Ser Pro Lys Phe Leu Arg Gln Asn Cys Ile Tyr Ser 
                805                 810                 815     


Thr Glu Ala Leu Thr Gly Lys Gly Pro Ser Gly Gln Glu Lys Cys Lys 
            820                 825                 830         


Leu Glu Asn His Ile Ser Pro Asp Val Arg Val Leu Pro Gly Gly Gly 
        835                 840                 845             


Ala His Gly Ser Thr Arg Asp Gln Ser Ile 
    850                 855             


<210> 30
<211> 911
<212> PRT
<213> Homo sapiens

<400> 30
Met Ala Glu Lys Ala Pro Pro Gly Leu Asn Arg Lys Thr Ser Arg Ser 
1               5                   10                  15      


Thr Leu Ser Leu Pro Pro Glu Pro Val Asp Ile Ile Arg Ser Lys Thr 
            20                  25                  30          


Cys Ser Arg Arg Val Lys Ile Asn Val Gly Gly Leu Asn His Glu Val 
        35                  40                  45              


Leu Trp Arg Thr Leu Asp Arg Leu Pro Arg Thr Arg Leu Gly Lys Leu 
    50                  55                  60                  


Arg Asp Cys Asn Thr His Glu Ser Leu Leu Glu Val Cys Asp Asp Tyr 
65                  70                  75                  80  


Asn Leu Asn Glu Asn Glu Tyr Phe Phe Asp Arg His Pro Gly Ala Phe 
                85                  90                  95      


Thr Ser Ile Leu Asn Phe Tyr Arg Thr Gly Lys Leu His Met Met Glu 
            100                 105                 110         


Glu Met Cys Ala Leu Ser Phe Gly Gln Glu Leu Asp Tyr Trp Gly Ile 
        115                 120                 125             


Asp Glu Ile Tyr Leu Glu Ser Cys Cys Gln Ala Arg Tyr His Gln Lys 
    130                 135                 140                 


Lys Glu Gln Met Asn Glu Glu Leu Arg Arg Glu Ala Glu Thr Met Arg 
145                 150                 155                 160 


Glu Arg Glu Gly Glu Glu Phe Asp Asn Thr Cys Cys Pro Asp Lys Arg 
                165                 170                 175     


Lys Lys Leu Trp Asp Leu Leu Glu Lys Pro Asn Ser Ser Val Ala Ala 
            180                 185                 190         


Lys Ile Leu Ala Ile Val Ser Ile Leu Phe Ile Val Leu Ser Thr Ile 
        195                 200                 205             


Ala Leu Ser Leu Asn Thr Leu Pro Glu Leu Gln Glu Thr Asp Glu Phe 
    210                 215                 220                 


Gly Gln Leu Asn Asp Asn Arg Gln Leu Ala His Val Glu Ala Val Cys 
225                 230                 235                 240 


Ile Ala Trp Phe Thr Met Glu Tyr Leu Leu Arg Phe Leu Ser Ser Pro 
                245                 250                 255     


Asn Lys Trp Lys Phe Phe Lys Gly Pro Leu Asn Val Ile Asp Leu Leu 
            260                 265                 270         


Ala Ile Leu Pro Tyr Tyr Val Thr Ile Phe Leu Thr Glu Ser Asn Lys 
        275                 280                 285             


Ser Val Leu Gln Phe Gln Asn Val Arg Arg Val Val Gln Ile Phe Arg 
    290                 295                 300                 


Ile Met Arg Ile Leu Arg Ile Leu Lys Leu Ala Arg His Ser Thr Gly 
305                 310                 315                 320 


Leu Gln Ser Leu Gly Phe Thr Leu Arg Arg Ser Tyr Asn Glu Leu Gly 
                325                 330                 335     


Leu Leu Ile Leu Phe Leu Ala Met Gly Ile Met Ile Phe Ser Ser Leu 
            340                 345                 350         


Val Phe Phe Ala Glu Lys Asp Glu Asp Ala Thr Lys Phe Thr Ser Ile 
        355                 360                 365             


Pro Ala Ser Phe Trp Trp Ala Thr Ile Thr Met Thr Thr Val Gly Tyr 
    370                 375                 380                 


Gly Asp Ile Tyr Pro Lys Thr Leu Leu Gly Lys Ile Val Gly Gly Leu 
385                 390                 395                 400 


Cys Cys Ile Ala Gly Val Leu Val Ile Ala Leu Pro Ile Pro Ile Ile 
                405                 410                 415     


Val Asn Asn Phe Ser Glu Phe Tyr Lys Glu Gln Lys Arg Gln Glu Lys 
            420                 425                 430         


Ala Ile Lys Arg Arg Glu Ala Leu Glu Arg Ala Lys Arg Asn Gly Ser 
        435                 440                 445             


Ile Val Ser Met Asn Leu Lys Asp Ala Phe Ala Arg Ser Met Glu Leu 
    450                 455                 460                 


Ile Asp Val Ala Val Glu Lys Ala Gly Glu Ser Ala Asn Thr Lys Asp 
465                 470                 475                 480 


Ser Ala Asp Asp Asn His Leu Ser Pro Ser Arg Trp Lys Trp Ala Arg 
                485                 490                 495     


Lys Ala Leu Ser Glu Thr Ser Ser Asn Lys Ser Phe Glu Asn Lys Tyr 
            500                 505                 510         


Gln Glu Val Ser Gln Lys Asp Ser His Glu Gln Leu Asn Asn Thr Ser 
        515                 520                 525             


Ser Ser Ser Pro Gln His Leu Ser Ala Gln Lys Leu Glu Met Leu Tyr 
    530                 535                 540                 


Asn Glu Ile Thr Lys Thr Gln Pro His Ser His Pro Asn Pro Asp Cys 
545                 550                 555                 560 


Gln Glu Lys Pro Glu Arg Pro Ser Ala Tyr Glu Glu Glu Ile Glu Met 
                565                 570                 575     


Glu Glu Val Val Cys Pro Gln Glu Gln Leu Ala Val Ala Gln Thr Glu 
            580                 585                 590         


Val Ile Val Asp Met Lys Ser Thr Ser Ser Ile Asp Ser Phe Thr Ser 
        595                 600                 605             


Cys Ala Thr Asp Phe Thr Glu Thr Glu Arg Ser Pro Leu Pro Pro Pro 
    610                 615                 620                 


Ser Ala Ser His Leu Gln Met Lys Phe Pro Thr Asp Leu Pro Gly Thr 
625                 630                 635                 640 


Glu Glu His Gln Arg Ala Arg Gly Pro Pro Phe Leu Thr Leu Ser Arg 
                645                 650                 655     


Glu Lys Gly Pro Ala Ala Arg Asp Gly Thr Leu Glu Tyr Ala Pro Val 
            660                 665                 670         


Asp Ile Thr Val Asn Leu Asp Ala Ser Gly Ser Gln Cys Gly Leu His 
        675                 680                 685             


Ser Pro Leu Gln Ser Asp Asn Ala Thr Asp Ser Pro Lys Ser Ser Leu 
    690                 695                 700                 


Lys Gly Ser Asn Pro Leu Lys Ser Arg Ser Leu Lys Val Asn Phe Lys 
705                 710                 715                 720 


Glu Asn Arg Gly Ser Ala Pro Gln Thr Pro Pro Ser Thr Ala Arg Pro 
                725                 730                 735     


Leu Pro Val Thr Thr Ala Asp Phe Ser Leu Thr Thr Pro Gln His Ile 
            740                 745                 750         


Ser Thr Ile Leu Leu Glu Glu Thr Pro Ser Gln Gly Asp Arg Pro Leu 
        755                 760                 765             


Leu Gly Thr Glu Val Ser Ala Pro Cys Gln Gly Pro Ser Lys Gly Leu 
    770                 775                 780                 


Ser Pro Arg Phe Pro Lys Gln Lys Leu Phe Pro Phe Ser Ser Arg Glu 
785                 790                 795                 800 


Arg Arg Ser Phe Thr Glu Ile Asp Thr Gly Asp Asp Glu Asp Phe Leu 
                805                 810                 815     


Glu Leu Pro Gly Ala Arg Glu Glu Lys Gln Val Asp Ser Ser Pro Asn 
            820                 825                 830         


Cys Phe Ala Asp Lys Pro Ser Asp Gly Arg Asp Pro Leu Arg Glu Glu 
        835                 840                 845             


Gly Ser Val Gly Ser Ser Ser Pro Gln Asp Thr Gly His Asn Cys Arg 
    850                 855                 860                 


Gln Asp Ile Tyr His Ala Val Ser Glu Val Lys Lys Asp Ser Ser Gln 
865                 870                 875                 880 


Glu Gly Cys Lys Met Glu Asn His Leu Phe Ala Pro Glu Ile His Ser 
                885                 890                 895     


Asn Pro Gly Asp Thr Gly Tyr Cys Pro Thr Arg Glu Thr Ser Met 
            900                 905                 910     


<210> 31
<211> 511
<212> PRT
<213> Homo sapiens

<400> 31
Met Gly Gln Gly Asp Glu Ser Glu Arg Ile Val Ile Asn Val Gly Gly 
1               5                   10                  15      


Thr Arg His Gln Thr Tyr Arg Ser Thr Leu Arg Thr Leu Pro Gly Thr 
            20                  25                  30          


Arg Leu Ala Trp Leu Ala Glu Pro Asp Ala His Ser His Phe Asp Tyr 
        35                  40                  45              


Asp Pro Arg Ala Asp Glu Phe Phe Phe Asp Arg His Pro Gly Val Phe 
    50                  55                  60                  


Ala His Ile Leu Asn Tyr Tyr Arg Thr Gly Lys Leu His Cys Pro Ala 
65                  70                  75                  80  


Asp Val Cys Gly Pro Leu Tyr Glu Glu Glu Leu Ala Phe Trp Gly Ile 
                85                  90                  95      


Asp Glu Thr Asp Val Glu Pro Cys Cys Trp Met Thr Tyr Arg Gln His 
            100                 105                 110         


Arg Asp Ala Glu Glu Ala Leu Asp Ser Phe Gly Gly Ala Pro Leu Asp 
        115                 120                 125             


Asn Ser Ala Asp Asp Ala Asp Ala Asp Gly Pro Gly Asp Ser Gly Asp 
    130                 135                 140                 


Gly Glu Asp Glu Leu Glu Met Thr Lys Arg Leu Ala Leu Ser Asp Ser 
145                 150                 155                 160 


Pro Asp Gly Arg Pro Gly Gly Phe Trp Arg Arg Trp Gln Pro Arg Ile 
                165                 170                 175     


Trp Ala Leu Phe Glu Asp Pro Tyr Ser Ser Arg Tyr Ala Arg Tyr Val 
            180                 185                 190         


Ala Phe Ala Ser Leu Phe Phe Ile Leu Val Ser Ile Thr Thr Phe Cys 
        195                 200                 205             


Leu Glu Thr His Glu Arg Phe Asn Pro Ile Val Asn Lys Thr Glu Ile 
    210                 215                 220                 


Glu Asn Val Arg Asn Gly Thr Gln Val Arg Tyr Tyr Arg Glu Ala Glu 
225                 230                 235                 240 


Thr Glu Ala Phe Leu Thr Tyr Ile Glu Gly Val Cys Val Val Trp Phe 
                245                 250                 255     


Thr Phe Glu Phe Leu Met Arg Val Ile Phe Cys Pro Asn Lys Val Glu 
            260                 265                 270         


Phe Ile Lys Asn Ser Leu Asn Ile Ile Asp Phe Val Ala Ile Leu Pro 
        275                 280                 285             


Phe Tyr Leu Glu Val Gly Leu Ser Gly Leu Ser Ser Lys Ala Ala Lys 
    290                 295                 300                 


Asp Val Leu Gly Phe Leu Arg Val Val Arg Phe Val Arg Ile Leu Arg 
305                 310                 315                 320 


Ile Phe Lys Leu Thr Arg His Phe Val Gly Leu Arg Val Leu Gly His 
                325                 330                 335     


Thr Leu Arg Ala Ser Thr Asn Glu Phe Leu Leu Leu Ile Ile Phe Leu 
            340                 345                 350         


Ala Leu Gly Val Leu Ile Phe Ala Thr Met Ile Tyr Tyr Ala Glu Arg 
        355                 360                 365             


Ile Gly Ala Gln Pro Asn Asp Pro Ser Ala Ser Glu His Thr His Phe 
    370                 375                 380                 


Lys Asn Ile Pro Ile Gly Phe Trp Trp Ala Val Val Thr Met Thr Thr 
385                 390                 395                 400 


Leu Gly Tyr Gly Asp Met Tyr Pro Gln Thr Trp Ser Gly Met Leu Val 
                405                 410                 415     


Gly Ala Leu Cys Ala Leu Ala Gly Val Leu Thr Ile Ala Met Pro Val 
            420                 425                 430         


Pro Val Ile Val Asn Asn Phe Gly Met Tyr Tyr Ser Leu Ala Met Ala 
        435                 440                 445             


Lys Gln Lys Leu Pro Lys Lys Lys Lys Lys His Ile Pro Arg Pro Pro 
    450                 455                 460                 


Gln Leu Gly Ser Pro Asn Tyr Cys Lys Ser Val Val Asn Ser Pro His 
465                 470                 475                 480 


His Ser Thr Gln Ser Asp Thr Cys Pro Leu Ala Gln Glu Glu Ile Leu 
                485                 490                 495     


Glu Ile Asn Arg Ala Gly Arg Lys Pro Leu Arg Gly Met Ser Ile 
            500                 505                 510     


<210> 32
<211> 613
<212> PRT
<213> Homo sapiens

<400> 32
Met Gly Lys Ile Glu Asn Asn Glu Arg Val Ile Leu Asn Val Gly Gly 
1               5                   10                  15      


Thr Arg His Glu Thr Tyr Arg Ser Thr Leu Lys Thr Leu Pro Gly Thr 
            20                  25                  30          


Arg Leu Ala Leu Leu Ala Ser Ser Glu Pro Pro Gly Asp Cys Leu Thr 
        35                  40                  45              


Thr Ala Gly Asp Lys Leu Gln Pro Ser Pro Pro Pro Leu Ser Pro Pro 
    50                  55                  60                  


Pro Arg Ala Pro Pro Leu Ser Pro Gly Pro Gly Gly Cys Phe Glu Gly 
65                  70                  75                  80  


Gly Ala Gly Asn Cys Ser Ser Arg Gly Gly Arg Ala Ser Asp His Pro 
                85                  90                  95      


Gly Gly Gly Arg Glu Phe Phe Phe Asp Arg His Pro Gly Val Phe Ala 
            100                 105                 110         


Tyr Val Leu Asn Tyr Tyr Arg Thr Gly Lys Leu His Cys Pro Ala Asp 
        115                 120                 125             


Val Cys Gly Pro Leu Phe Glu Glu Glu Leu Ala Phe Trp Gly Ile Asp 
    130                 135                 140                 


Glu Thr Asp Val Glu Pro Cys Cys Trp Met Thr Tyr Arg Gln His Arg 
145                 150                 155                 160 


Asp Ala Glu Glu Ala Leu Asp Ile Phe Glu Thr Pro Asp Leu Ile Gly 
                165                 170                 175     


Gly Asp Pro Gly Asp Asp Glu Asp Leu Ala Ala Lys Arg Leu Gly Ile 
            180                 185                 190         


Glu Asp Ala Ala Gly Leu Gly Gly Pro Asp Gly Lys Ser Gly Arg Trp 
        195                 200                 205             


Arg Arg Leu Gln Pro Arg Met Trp Ala Leu Phe Glu Asp Pro Tyr Ser 
    210                 215                 220                 


Ser Arg Ala Ala Arg Phe Ile Ala Phe Ala Ser Leu Phe Phe Ile Leu 
225                 230                 235                 240 


Val Ser Ile Thr Thr Phe Cys Leu Glu Thr His Glu Ala Phe Asn Ile 
                245                 250                 255     


Val Lys Asn Lys Thr Glu Pro Val Ile Asn Gly Thr Ser Val Val Leu 
            260                 265                 270         


Gln Tyr Glu Ile Glu Thr Asp Pro Ala Leu Thr Tyr Val Glu Gly Val 
        275                 280                 285             


Cys Val Val Trp Phe Thr Phe Glu Phe Leu Val Arg Ile Val Phe Ser 
    290                 295                 300                 


Pro Asn Lys Leu Glu Phe Ile Lys Asn Leu Leu Asn Ile Ile Asp Phe 
305                 310                 315                 320 


Val Ala Ile Leu Pro Phe Tyr Leu Glu Val Gly Leu Ser Gly Leu Ser 
                325                 330                 335     


Ser Lys Ala Ala Lys Asp Val Leu Gly Phe Leu Arg Val Val Arg Phe 
            340                 345                 350         


Val Arg Ile Leu Arg Ile Phe Lys Leu Thr Arg His Phe Val Gly Leu 
        355                 360                 365             


Arg Val Leu Gly His Thr Leu Arg Ala Ser Thr Asn Glu Phe Leu Leu 
    370                 375                 380                 


Leu Ile Ile Phe Leu Ala Leu Gly Val Leu Ile Phe Ala Thr Met Ile 
385                 390                 395                 400 


Tyr Tyr Ala Glu Arg Val Gly Ala Gln Pro Asn Asp Pro Ser Ala Ser 
                405                 410                 415     


Glu His Thr Gln Phe Lys Asn Ile Pro Ile Gly Phe Trp Trp Ala Val 
            420                 425                 430         


Val Thr Met Thr Thr Leu Gly Tyr Gly Asp Met Tyr Pro Gln Thr Trp 
        435                 440                 445             


Ser Gly Met Leu Val Gly Ala Leu Cys Ala Leu Ala Gly Val Leu Thr 
    450                 455                 460                 


Ile Ala Met Pro Val Pro Val Ile Val Asn Asn Phe Gly Met Tyr Tyr 
465                 470                 475                 480 


Ser Leu Ala Met Ala Lys Gln Lys Leu Pro Arg Lys Arg Lys Lys His 
                485                 490                 495     


Ile Pro Pro Ala Pro Gln Ala Ser Ser Pro Thr Phe Cys Lys Thr Glu 
            500                 505                 510         


Leu Asn Met Ala Cys Asn Ser Thr Gln Ser Asp Thr Cys Leu Gly Lys 
        515                 520                 525             


Asp Asn Arg Leu Leu Glu His Asn Arg Ser Val Leu Ser Gly Asp Asp 
    530                 535                 540                 


Ser Thr Gly Ser Glu Pro Pro Leu Ser Pro Pro Glu Arg Leu Pro Ile 
545                 550                 555                 560 


Arg Arg Ser Ser Thr Arg Asp Lys Asn Arg Arg Gly Glu Thr Cys Phe 
                565                 570                 575     


Leu Leu Thr Thr Gly Asp Tyr Thr Cys Ala Ser Asp Gly Gly Ile Arg 
            580                 585                 590         


Lys Asp Asn Cys Lys Glu Val Val Ile Thr Gly Tyr Thr Gln Ala Glu 
        595                 600                 605             


Ala Arg Ser Leu Thr 
    610             


<210> 33
<211> 757
<212> PRT
<213> Homo sapiens

<400> 33
Met Leu Ser Ser Val Cys Val Ser Ser Phe Arg Gly Arg Gln Gly Ala 
1               5                   10                  15      


Ser Lys Gln Gln Pro Ala Pro Pro Pro Gln Pro Pro Glu Ser Pro Pro 
            20                  25                  30          


Pro Pro Pro Leu Pro Pro Gln Gln Gln Gln Pro Ala Gln Pro Gly Pro 
        35                  40                  45              


Ala Ala Ser Pro Ala Gly Pro Pro Ala Pro Arg Gly Pro Gly Asp Arg 
    50                  55                  60                  


Arg Ala Glu Pro Cys Pro Gly Leu Pro Ala Ala Ala Met Gly Arg His 
65                  70                  75                  80  


Gly Gly Gly Gly Gly Asp Ser Gly Lys Ile Val Ile Asn Val Gly Gly 
                85                  90                  95      


Val Arg His Glu Thr Tyr Arg Ser Thr Leu Arg Thr Leu Pro Gly Thr 
            100                 105                 110         


Arg Leu Ala Gly Leu Thr Glu Pro Glu Ala Ala Ala Arg Phe Asp Tyr 
        115                 120                 125             


Asp Pro Gly Ala Asp Glu Phe Phe Phe Asp Arg His Pro Gly Val Phe 
    130                 135                 140                 


Ala Tyr Val Leu Asn Tyr Tyr Arg Thr Gly Lys Leu His Cys Pro Ala 
145                 150                 155                 160 


Asp Val Cys Gly Pro Leu Phe Glu Glu Glu Leu Gly Phe Trp Gly Ile 
                165                 170                 175     


Asp Glu Thr Asp Val Glu Ala Cys Cys Trp Met Thr Tyr Arg Gln His 
            180                 185                 190         


Arg Asp Ala Glu Glu Ala Leu Asp Ser Phe Glu Ala Pro Asp Pro Ala 
        195                 200                 205             


Gly Ala Ala Asn Ala Ala Asn Ala Ala Gly Ala His Asp Gly Gly Leu 
    210                 215                 220                 


Asp Asp Glu Ala Gly Ala Gly Gly Gly Gly Leu Asp Gly Ala Gly Gly 
225                 230                 235                 240 


Glu Leu Lys Arg Leu Cys Phe Gln Asp Ala Gly Gly Gly Ala Gly Gly 
                245                 250                 255     


Pro Pro Gly Gly Ala Gly Gly Ala Gly Gly Thr Trp Trp Arg Arg Trp 
            260                 265                 270         


Gln Pro Arg Val Trp Ala Leu Phe Glu Asp Pro Tyr Ser Ser Arg Ala 
        275                 280                 285             


Ala Arg Tyr Val Ala Phe Ala Ser Leu Phe Phe Ile Leu Ile Ser Ile 
    290                 295                 300                 


Thr Thr Phe Cys Leu Glu Thr His Glu Gly Phe Ile His Ile Ser Asn 
305                 310                 315                 320 


Lys Thr Val Thr Gln Ala Ser Pro Ile Pro Gly Ala Pro Pro Glu Asn 
                325                 330                 335     


Ile Thr Asn Val Glu Val Glu Thr Glu Pro Phe Leu Thr Tyr Val Glu 
            340                 345                 350         


Gly Val Cys Val Val Trp Phe Thr Phe Glu Phe Leu Met Arg Ile Thr 
        355                 360                 365             


Phe Cys Pro Asp Lys Val Glu Phe Leu Lys Ser Ser Leu Asn Ile Ile 
    370                 375                 380                 


Asp Cys Val Ala Ile Leu Pro Phe Tyr Leu Glu Val Gly Leu Ser Gly 
385                 390                 395                 400 


Leu Ser Ser Lys Ala Ala Lys Asp Val Leu Gly Phe Leu Arg Val Val 
                405                 410                 415     


Arg Phe Val Arg Ile Leu Arg Ile Phe Lys Leu Thr Arg His Phe Val 
            420                 425                 430         


Gly Leu Arg Val Leu Gly His Thr Leu Arg Ala Ser Thr Asn Glu Phe 
        435                 440                 445             


Leu Leu Leu Ile Ile Phe Leu Ala Leu Gly Val Leu Ile Phe Ala Thr 
    450                 455                 460                 


Met Ile Tyr Tyr Ala Glu Arg Ile Gly Ala Asp Pro Asp Asp Ile Leu 
465                 470                 475                 480 


Gly Ser Asn His Thr Tyr Phe Lys Asn Ile Pro Ile Gly Phe Trp Trp 
                485                 490                 495     


Ala Val Val Thr Met Thr Thr Leu Gly Tyr Gly Asp Met Tyr Pro Lys 
            500                 505                 510         


Thr Trp Ser Gly Met Leu Val Gly Ala Leu Cys Ala Leu Ala Gly Val 
        515                 520                 525             


Leu Thr Ile Ala Met Pro Val Pro Val Ile Val Asn Asn Phe Gly Met 
    530                 535                 540                 


Tyr Tyr Ser Leu Ala Met Ala Lys Gln Lys Leu Pro Lys Lys Lys Asn 
545                 550                 555                 560 


Lys His Ile Pro Arg Pro Pro Gln Pro Gly Ser Pro Asn Tyr Cys Lys 
                565                 570                 575     


Pro Asp Pro Pro Pro Pro Pro Pro Pro His Pro His His Gly Ser Gly 
            580                 585                 590         


Gly Ile Ser Pro Pro Pro Pro Ile Thr Pro Pro Ser Met Gly Val Thr 
        595                 600                 605             


Val Ala Gly Ala Tyr Pro Ala Gly Pro His Thr His Pro Gly Leu Leu 
    610                 615                 620                 


Arg Gly Gly Ala Gly Gly Leu Gly Ile Met Gly Leu Pro Pro Leu Pro 
625                 630                 635                 640 


Ala Pro Gly Glu Pro Cys Pro Leu Ala Gln Glu Glu Val Ile Glu Ile 
                645                 650                 655     


Asn Arg Ala Asp Pro Arg Pro Asn Gly Asp Pro Ala Ala Ala Ala Leu 
            660                 665                 670         


Ala His Glu Asp Cys Pro Ala Ile Asp Gln Pro Ala Met Ser Pro Glu 
        675                 680                 685             


Asp Lys Ser Pro Ile Thr Pro Gly Ser Arg Gly Arg Tyr Ser Arg Asp 
    690                 695                 700                 


Arg Ala Cys Phe Leu Leu Thr Asp Tyr Ala Pro Ser Pro Asp Gly Ser 
705                 710                 715                 720 


Ile Arg Lys Ala Thr Gly Ala Pro Pro Leu Pro Pro Gln Asp Trp Arg 
                725                 730                 735     


Lys Pro Gly Pro Pro Ser Phe Leu Pro Asp Leu Asn Ala Asn Ala Ala 
            740                 745                 750         


Ala Trp Ile Ser Pro 
        755         


<210> 34
<211> 635
<212> PRT
<213> Homo sapiens

<400> 34
Met Ile Ser Ser Val Cys Val Ser Ser Tyr Arg Gly Arg Lys Ser Gly 
1               5                   10                  15      


Asn Lys Pro Pro Ser Lys Thr Cys Leu Lys Glu Glu Met Ala Lys Gly 
            20                  25                  30          


Glu Ala Ser Glu Lys Ile Ile Ile Asn Val Gly Gly Thr Arg His Glu 
        35                  40                  45              


Thr Tyr Arg Ser Thr Leu Arg Thr Leu Pro Gly Thr Arg Leu Ala Trp 
    50                  55                  60                  


Leu Ala Asp Pro Asp Gly Gly Gly Arg Pro Glu Thr Asp Gly Gly Gly 
65                  70                  75                  80  


Val Gly Ser Ser Gly Ser Ser Gly Gly Gly Gly Cys Glu Phe Phe Phe 
                85                  90                  95      


Asp Arg His Pro Gly Val Phe Ala Tyr Val Leu Asn Tyr Tyr Arg Thr 
            100                 105                 110         


Gly Lys Leu His Cys Pro Ala Asp Val Cys Gly Pro Leu Phe Glu Glu 
        115                 120                 125             


Glu Leu Thr Phe Trp Gly Ile Asp Glu Thr Asp Val Glu Pro Cys Cys 
    130                 135                 140                 


Trp Met Thr Tyr Arg Gln His Arg Asp Ala Glu Glu Ala Leu Asp Ile 
145                 150                 155                 160 


Phe Glu Ser Pro Asp Gly Gly Gly Ser Gly Ala Gly Pro Ser Asp Glu 
                165                 170                 175     


Ala Gly Asp Asp Glu Arg Glu Leu Ala Leu Gln Arg Leu Gly Pro His 
            180                 185                 190         


Glu Gly Gly Ala Gly His Gly Ala Gly Ser Gly Gly Cys Arg Gly Trp 
        195                 200                 205             


Gln Pro Arg Met Trp Ala Leu Phe Glu Asp Pro Tyr Ser Ser Arg Ala 
    210                 215                 220                 


Ala Arg Val Val Ala Phe Ala Ser Leu Phe Phe Ile Leu Val Ser Ile 
225                 230                 235                 240 


Thr Thr Phe Cys Leu Glu Thr His Glu Ala Phe Asn Ile Asp Arg Asn 
                245                 250                 255     


Val Thr Glu Ile Leu Arg Val Gly Asn Ile Thr Ser Val His Phe Arg 
            260                 265                 270         


Arg Glu Val Glu Thr Glu Pro Ile Leu Thr Tyr Ile Glu Gly Val Cys 
        275                 280                 285             


Val Leu Trp Phe Thr Leu Glu Phe Leu Val Arg Ile Val Cys Cys Pro 
    290                 295                 300                 


Asp Thr Leu Asp Phe Val Lys Asn Leu Leu Asn Ile Ile Asp Phe Val 
305                 310                 315                 320 


Ala Ile Leu Pro Phe Tyr Leu Glu Val Gly Leu Ser Gly Leu Ser Ser 
                325                 330                 335     


Lys Ala Ala Arg Asp Val Leu Gly Phe Leu Arg Val Val Arg Phe Val 
            340                 345                 350         


Arg Ile Leu Arg Ile Phe Lys Leu Thr Arg His Phe Val Gly Leu Arg 
        355                 360                 365             


Val Leu Gly His Thr Leu Arg Ala Ser Thr Asn Glu Phe Leu Leu Leu 
    370                 375                 380                 


Ile Ile Phe Leu Ala Leu Gly Val Leu Ile Phe Ala Thr Met Ile Tyr 
385                 390                 395                 400 


Tyr Ala Glu Arg Ile Gly Ala Arg Pro Ser Asp Pro Arg Gly Asn Asp 
                405                 410                 415     


His Thr Asp Phe Lys Asn Ile Pro Ile Gly Phe Trp Trp Ala Val Val 
            420                 425                 430         


Thr Met Thr Thr Leu Gly Tyr Gly Asp Met Tyr Pro Lys Thr Trp Ser 
        435                 440                 445             


Gly Met Leu Val Gly Ala Leu Cys Ala Leu Ala Gly Val Leu Thr Ile 
    450                 455                 460                 


Ala Met Pro Val Pro Val Ile Val Asn Asn Phe Gly Met Tyr Tyr Ser 
465                 470                 475                 480 


Leu Ala Met Ala Lys Gln Lys Leu Pro Lys Lys Arg Lys Lys His Val 
                485                 490                 495     


Pro Arg Pro Ala Gln Leu Glu Ser Pro Met Tyr Cys Lys Ser Glu Glu 
            500                 505                 510         


Thr Ser Pro Arg Asp Ser Thr Cys Ser Asp Thr Ser Pro Pro Ala Arg 
        515                 520                 525             


Glu Glu Gly Met Ile Glu Arg Lys Arg Ala Asp Ser Lys Gln Asn Gly 
    530                 535                 540                 


Asp Ala Asn Ala Val Leu Ser Asp Glu Glu Gly Ala Gly Leu Thr Gln 
545                 550                 555                 560 


Pro Leu Ala Ser Ser Pro Thr Pro Glu Glu Arg Arg Ala Leu Arg Arg 
                565                 570                 575     


Ser Thr Thr Arg Asp Arg Asn Lys Lys Ala Ala Ala Cys Phe Leu Leu 
            580                 585                 590         


Ser Thr Gly Asp Tyr Ala Cys Ala Asp Gly Ser Val Arg Lys Gly Thr 
        595                 600                 605             


Phe Val Leu Arg Asp Leu Pro Leu Gln His Ser Pro Glu Ala Ala Cys 
    610                 615                 620                 


Pro Pro Thr Ala Gly Thr Leu Phe Leu Pro His 
625                 630                 635 


<210> 35
<211> 647
<212> PRT
<213> Homo sapiens

<400> 35
Met Ala Ala Gly Leu Ala Thr Trp Leu Pro Phe Ala Arg Ala Ala Ala 
1               5                   10                  15      


Val Gly Trp Leu Pro Leu Ala Gln Gln Pro Leu Pro Pro Ala Pro Gly 
            20                  25                  30          


Val Lys Ala Ser Arg Gly Asp Glu Val Leu Val Val Asn Val Ser Gly 
        35                  40                  45              


Arg Arg Phe Glu Thr Trp Lys Asn Thr Leu Asp Arg Tyr Pro Asp Thr 
    50                  55                  60                  


Leu Leu Gly Ser Ser Glu Lys Glu Phe Phe Tyr Asp Ala Asp Ser Gly 
65                  70                  75                  80  


Glu Tyr Phe Phe Asp Arg Asp Pro Asp Met Phe Arg His Val Leu Asn 
                85                  90                  95      


Phe Tyr Arg Thr Gly Arg Leu His Cys Pro Arg Gln Glu Cys Ile Gln 
            100                 105                 110         


Ala Phe Asp Glu Glu Leu Ala Phe Tyr Gly Leu Val Pro Glu Leu Val 
        115                 120                 125             


Gly Asp Cys Cys Leu Glu Glu Tyr Arg Asp Arg Lys Lys Glu Asn Ala 
    130                 135                 140                 


Glu Arg Leu Ala Glu Asp Glu Glu Ala Glu Gln Ala Gly Asp Gly Pro 
145                 150                 155                 160 


Ala Leu Pro Ala Gly Ser Ser Leu Arg Gln Arg Leu Trp Arg Ala Phe 
                165                 170                 175     


Glu Asn Pro His Thr Ser Thr Ala Ala Leu Val Phe Tyr Tyr Val Thr 
            180                 185                 190         


Gly Phe Phe Ile Ala Val Ser Val Ile Ala Asn Val Val Glu Thr Ile 
        195                 200                 205             


Pro Cys Arg Gly Ser Ala Arg Arg Ser Ser Arg Glu Gln Pro Cys Gly 
    210                 215                 220                 


Glu Arg Phe Pro Gln Ala Phe Phe Cys Met Asp Thr Ala Cys Val Leu 
225                 230                 235                 240 


Ile Phe Thr Gly Glu Tyr Leu Leu Arg Leu Phe Ala Ala Pro Ser Arg 
                245                 250                 255     


Cys Arg Phe Leu Arg Ser Val Met Ser Leu Ile Asp Val Val Ala Ile 
            260                 265                 270         


Leu Pro Tyr Tyr Ile Gly Leu Leu Val Pro Lys Asn Asp Asp Val Ser 
        275                 280                 285             


Gly Ala Phe Val Thr Leu Arg Val Phe Arg Val Phe Arg Ile Phe Lys 
    290                 295                 300                 


Phe Ser Arg His Ser Gln Gly Leu Arg Ile Leu Gly Tyr Thr Leu Lys 
305                 310                 315                 320 


Ser Cys Ala Ser Glu Leu Gly Phe Leu Leu Phe Ser Leu Thr Met Ala 
                325                 330                 335     


Ile Ile Ile Phe Ala Thr Val Met Phe Tyr Ala Glu Lys Gly Thr Asn 
            340                 345                 350         


Lys Thr Asn Phe Thr Ser Ile Pro Ala Ala Phe Trp Tyr Thr Ile Val 
        355                 360                 365             


Thr Met Thr Thr Leu Gly Tyr Gly Asp Met Val Pro Ser Thr Ile Ala 
    370                 375                 380                 


Gly Lys Ile Phe Gly Ser Ile Cys Ser Leu Ser Gly Val Leu Val Ile 
385                 390                 395                 400 


Ala Leu Pro Val Pro Val Ile Val Ser Asn Phe Ser Arg Ile Tyr His 
                405                 410                 415     


Gln Asn Gln Arg Ala Asp Lys Arg Arg Ala Gln Gln Lys Val Arg Leu 
            420                 425                 430         


Ala Arg Ile Arg Leu Ala Lys Ser Gly Thr Thr Asn Ala Phe Leu Gln 
        435                 440                 445             


Tyr Lys Gln Asn Gly Gly Leu Glu Asp Ser Gly Ser Gly Glu Glu Gln 
    450                 455                 460                 


Ala Leu Cys Val Arg Asn Arg Ser Ala Phe Glu Gln Gln His His His 
465                 470                 475                 480 


Leu Leu His Cys Leu Glu Lys Thr Thr Cys His Glu Phe Thr Asp Glu 
                485                 490                 495     


Leu Thr Phe Ser Glu Ala Leu Gly Ala Val Ser Pro Gly Gly Arg Thr 
            500                 505                 510         


Ser Arg Ser Thr Ser Val Ser Ser Gln Pro Val Gly Pro Gly Ser Leu 
        515                 520                 525             


Leu Ser Ser Cys Cys Pro Arg Arg Ala Lys Arg Arg Ala Ile Arg Leu 
    530                 535                 540                 


Ala Asn Ser Thr Ala Ser Val Ser Arg Gly Ser Met Gln Glu Leu Asp 
545                 550                 555                 560 


Met Leu Ala Gly Leu Arg Arg Ser His Ala Pro Gln Ser Arg Ser Ser 
                565                 570                 575     


Leu Asn Ala Lys Pro His Asp Ser Leu Asp Leu Asn Cys Asp Ser Arg 
            580                 585                 590         


Asp Phe Val Ala Ala Ile Ile Ser Ile Pro Thr Pro Pro Ala Asn Thr 
        595                 600                 605             


Pro Asp Glu Ser Gln Pro Ser Ser Pro Gly Gly Gly Gly Arg Ala Gly 
    610                 615                 620                 


Ser Thr Leu Arg Asn Ser Ser Leu Gly Thr Pro Cys Leu Phe Pro Glu 
625                 630                 635                 640 


Thr Val Lys Ile Ser Ser Leu 
                645         


<210> 36
<211> 630
<212> PRT
<213> Homo sapiens

<400> 36
Met Ala Ala Gly Val Ala Ala Trp Leu Pro Phe Ala Arg Ala Ala Ala 
1               5                   10                  15      


Ile Gly Trp Met Pro Val Ala Ser Gly Pro Met Pro Ala Pro Pro Arg 
            20                  25                  30          


Gln Glu Arg Lys Arg Thr Gln Asp Ala Leu Ile Val Leu Asn Val Ser 
        35                  40                  45              


Gly Thr Arg Phe Gln Thr Trp Gln Asp Thr Leu Glu Arg Tyr Pro Asp 
    50                  55                  60                  


Thr Leu Leu Gly Ser Ser Glu Arg Asp Phe Phe Tyr His Pro Glu Thr 
65                  70                  75                  80  


Gln Gln Tyr Phe Phe Asp Arg Asp Pro Asp Ile Phe Arg His Ile Leu 
                85                  90                  95      


Asn Phe Tyr Arg Thr Gly Lys Leu His Tyr Pro Arg His Glu Cys Ile 
            100                 105                 110         


Ser Ala Tyr Asp Glu Glu Leu Ala Phe Phe Gly Leu Ile Pro Glu Ile 
        115                 120                 125             


Ile Gly Asp Cys Cys Tyr Glu Glu Tyr Lys Asp Arg Arg Arg Glu Asn 
    130                 135                 140                 


Ala Glu Arg Leu Gln Asp Asp Ala Asp Thr Asp Thr Ala Gly Glu Ser 
145                 150                 155                 160 


Ala Leu Pro Thr Met Thr Ala Arg Gln Arg Val Trp Arg Ala Phe Glu 
                165                 170                 175     


Asn Pro His Thr Ser Thr Met Ala Leu Val Phe Tyr Tyr Val Thr Gly 
            180                 185                 190         


Phe Phe Ile Ala Val Ser Val Ile Ala Asn Val Val Glu Thr Val Pro 
        195                 200                 205             


Cys Gly Ser Ser Pro Gly His Ile Lys Glu Leu Pro Cys Gly Glu Arg 
    210                 215                 220                 


Tyr Ala Val Ala Phe Phe Cys Leu Asp Thr Ala Cys Val Met Ile Phe 
225                 230                 235                 240 


Thr Val Glu Tyr Leu Leu Arg Leu Ala Ala Ala Pro Ser Arg Tyr Arg 
                245                 250                 255     


Phe Val Arg Ser Val Met Ser Ile Ile Asp Val Val Ala Ile Leu Pro 
            260                 265                 270         


Tyr Tyr Ile Gly Leu Val Met Thr Asp Asn Glu Asp Val Ser Gly Ala 
        275                 280                 285             


Phe Val Thr Leu Arg Val Phe Arg Val Phe Arg Ile Phe Lys Phe Ser 
    290                 295                 300                 


Arg His Ser Gln Gly Leu Arg Ile Leu Gly Tyr Thr Leu Lys Ser Cys 
305                 310                 315                 320 


Ala Ser Glu Leu Gly Phe Leu Leu Phe Ser Leu Thr Met Ala Ile Ile 
                325                 330                 335     


Ile Phe Ala Thr Val Met Phe Tyr Ala Glu Lys Gly Ser Ser Ala Ser 
            340                 345                 350         


Lys Phe Thr Ser Ile Pro Ala Ala Phe Trp Tyr Thr Ile Val Thr Met 
        355                 360                 365             


Thr Thr Leu Gly Tyr Gly Asp Met Val Pro Lys Thr Ile Ala Gly Lys 
    370                 375                 380                 


Ile Phe Gly Ser Ile Cys Ser Leu Ser Gly Val Leu Val Ile Ala Leu 
385                 390                 395                 400 


Pro Val Pro Val Ile Val Ser Asn Phe Ser Arg Ile Tyr His Gln Asn 
                405                 410                 415     


Gln Arg Ala Asp Lys Arg Arg Ala Gln Lys Lys Ala Arg Leu Ala Arg 
            420                 425                 430         


Ile Arg Ala Ala Lys Ser Gly Ser Ala Asn Ala Tyr Met Gln Ser Lys 
        435                 440                 445             


Arg Asn Gly Leu Leu Ser Asn Gln Leu Gln Ser Ser Glu Asp Glu Gln 
    450                 455                 460                 


Ala Phe Val Ser Lys Ser Gly Ser Ser Phe Glu Thr Gln His His His 
465                 470                 475                 480 


Leu Leu His Cys Leu Glu Lys Thr Thr Asn His Glu Phe Val Asp Glu 
                485                 490                 495     


Gln Val Phe Glu Glu Ser Cys Met Glu Val Ala Thr Val Asn Arg Pro 
            500                 505                 510         


Ser Ser His Ser Pro Ser Leu Ser Ser Gln Gln Gly Val Thr Ser Thr 
        515                 520                 525             


Cys Cys Ser Arg Arg His Lys Lys Thr Phe Arg Ile Pro Asn Ala Asn 
    530                 535                 540                 


Val Ser Gly Ser His Gln Gly Ser Ile Gln Glu Leu Ser Thr Ile Gln 
545                 550                 555                 560 


Ile Arg Cys Val Glu Arg Thr Pro Leu Ser Asn Ser Arg Ser Ser Leu 
                565                 570                 575     


Asn Ala Lys Met Glu Glu Cys Val Lys Leu Asn Cys Glu Gln Pro Tyr 
            580                 585                 590         


Val Thr Thr Ala Ile Ile Ser Ile Pro Thr Pro Pro Val Thr Thr Pro 
        595                 600                 605             


Glu Gly Asp Asp Arg Pro Glu Ser Pro Glu Tyr Ser Gly Gly Asn Ile 
    610                 615                 620                 


Val Arg Val Ser Ala Leu 
625                 630 


<210> 37
<211> 655
<212> PRT
<213> Homo sapiens

<400> 37
Met Ala Ala Gly Val Ala Ala Trp Leu Pro Phe Ala Arg Ala Ala Ala 
1               5                   10                  15      


Ile Gly Trp Met Pro Val Ala Asn Cys Pro Met Pro Leu Ala Pro Ala 
            20                  25                  30          


Asp Lys Asn Lys Arg Gln Asp Glu Leu Ile Val Leu Asn Val Ser Gly 
        35                  40                  45              


Arg Arg Phe Gln Thr Trp Arg Thr Thr Leu Glu Arg Tyr Pro Asp Thr 
    50                  55                  60                  


Leu Leu Gly Ser Thr Glu Lys Glu Phe Phe Phe Asn Glu Asp Thr Lys 
65                  70                  75                  80  


Glu Tyr Phe Phe Asp Arg Asp Pro Glu Val Phe Arg Cys Val Leu Asn 
                85                  90                  95      


Phe Tyr Arg Thr Gly Lys Leu His Tyr Pro Arg Tyr Glu Cys Ile Ser 
            100                 105                 110         


Ala Tyr Asp Asp Glu Leu Ala Phe Tyr Gly Ile Leu Pro Glu Ile Ile 
        115                 120                 125             


Gly Asp Cys Cys Tyr Glu Glu Tyr Lys Asp Arg Lys Arg Glu Asn Ala 
    130                 135                 140                 


Glu Arg Leu Met Asp Asp Asn Asp Ser Glu Asn Asn Gln Glu Ser Met 
145                 150                 155                 160 


Pro Ser Leu Ser Phe Arg Gln Thr Met Trp Arg Ala Phe Glu Asn Pro 
                165                 170                 175     


His Thr Ser Thr Leu Ala Leu Val Phe Tyr Tyr Val Thr Gly Phe Phe 
            180                 185                 190         


Ile Ala Val Ser Val Ile Thr Asn Val Val Glu Thr Val Pro Cys Gly 
        195                 200                 205             


Thr Val Pro Gly Ser Lys Glu Leu Pro Cys Gly Glu Arg Tyr Ser Val 
    210                 215                 220                 


Ala Phe Phe Cys Leu Asp Thr Ala Cys Val Met Ile Phe Thr Val Glu 
225                 230                 235                 240 


Tyr Leu Leu Arg Leu Phe Ala Ala Pro Ser Arg Tyr Arg Phe Ile Arg 
                245                 250                 255     


Ser Val Met Ser Ile Ile Asp Val Val Ala Ile Met Pro Tyr Tyr Ile 
            260                 265                 270         


Gly Leu Val Met Thr Asn Asn Glu Asp Val Ser Gly Ala Phe Val Thr 
        275                 280                 285             


Leu Arg Val Phe Arg Val Phe Arg Ile Phe Lys Phe Ser Arg His Ser 
    290                 295                 300                 


Gln Gly Leu Arg Ile Leu Gly Tyr Thr Leu Lys Ser Cys Ala Ser Glu 
305                 310                 315                 320 


Leu Gly Phe Leu Leu Phe Ser Leu Thr Met Ala Ile Ile Ile Phe Ala 
                325                 330                 335     


Thr Val Met Phe Tyr Ala Glu Lys Gly Ser Ser Ala Ser Lys Phe Thr 
            340                 345                 350         


Ser Ile Pro Ala Ser Phe Trp Tyr Thr Ile Val Thr Met Thr Thr Leu 
        355                 360                 365             


Gly Tyr Gly Asp Met Val Pro Lys Thr Ile Ala Gly Lys Ile Phe Gly 
    370                 375                 380                 


Ser Ile Cys Ser Leu Ser Gly Val Leu Val Ile Ala Leu Pro Val Pro 
385                 390                 395                 400 


Val Ile Val Ser Asn Phe Ser Arg Ile Tyr His Gln Asn Gln Arg Ala 
                405                 410                 415     


Asp Lys Arg Arg Ala Gln Lys Lys Ala Arg Leu Ala Arg Ile Arg Val 
            420                 425                 430         


Ala Lys Thr Gly Ser Ser Asn Ala Tyr Leu His Ser Lys Arg Asn Gly 
        435                 440                 445             


Leu Leu Asn Glu Ala Leu Glu Leu Thr Gly Thr Pro Glu Glu Glu His 
    450                 455                 460                 


Met Gly Lys Thr Thr Ser Leu Ile Glu Ser Gln His His His Leu Leu 
465                 470                 475                 480 


His Cys Leu Glu Lys Thr Thr Gly Leu Ser Tyr Leu Val Asp Asp Pro 
                485                 490                 495     


Leu Leu Ser Val Arg Thr Ser Thr Ile Lys Asn His Glu Phe Ile Asp 
            500                 505                 510         


Glu Gln Met Phe Glu Gln Asn Cys Met Glu Ser Ser Met Gln Asn Tyr 
        515                 520                 525             


Pro Ser Thr Arg Ser Pro Ser Leu Ser Ser His Pro Gly Leu Thr Thr 
    530                 535                 540                 


Thr Cys Cys Ser Arg Arg Ser Lys Lys Thr Thr His Leu Pro Asn Ser 
545                 550                 555                 560 


Asn Leu Pro Ala Thr Arg Leu Arg Ser Met Gln Glu Leu Ser Thr Ile 
                565                 570                 575     


His Ile Gln Gly Ser Glu Gln Pro Ser Leu Thr Thr Ser Arg Ser Ser 
            580                 585                 590         


Leu Asn Leu Lys Ala Asp Asp Gly Leu Arg Pro Asn Cys Lys Thr Ser 
        595                 600                 605             


Gln Ile Thr Thr Ala Ile Ile Ser Ile Pro Thr Pro Pro Ala Leu Thr 
    610                 615                 620                 


Pro Glu Gly Glu Ser Arg Pro Pro Pro Ala Ser Pro Gly Pro Asn Thr 
625                 630                 635                 640 


Asn Ile Pro Ser Ile Ala Ser Asn Val Val Lys Val Ser Ala Leu 
                645                 650                 655 


<210> 38
<211> 494
<212> PRT
<213> Homo sapiens

<400> 38
Met Asp Gly Ser Gly Glu Arg Ser Leu Pro Glu Pro Gly Ser Gln Ser 
1               5                   10                  15      


Ser Ala Ala Ser Asp Asp Ile Glu Ile Val Val Asn Val Gly Gly Val 
            20                  25                  30          


Arg Gln Val Leu Tyr Gly Asp Leu Leu Ser Gln Tyr Pro Glu Thr Arg 
        35                  40                  45              


Leu Ala Glu Leu Ile Asn Cys Leu Ala Gly Gly Tyr Asp Thr Ile Phe 
    50                  55                  60                  


Ser Leu Cys Asp Asp Tyr Asp Pro Gly Lys Arg Glu Phe Tyr Phe Asp 
65                  70                  75                  80  


Arg Asp Pro Asp Ala Phe Lys Cys Val Ile Glu Val Tyr Tyr Phe Gly 
                85                  90                  95      


Glu Val His Met Lys Lys Gly Ile Cys Pro Ile Cys Phe Lys Asn Glu 
            100                 105                 110         


Met Asp Phe Trp Lys Val Asp Leu Lys Phe Leu Asp Asp Cys Cys Lys 
        115                 120                 125             


Ser His Leu Ser Glu Lys Arg Glu Glu Leu Glu Glu Ile Ala Arg Arg 
    130                 135                 140                 


Val Gln Leu Ile Leu Asp Asp Leu Gly Val Asp Ala Ala Glu Gly Arg 
145                 150                 155                 160 


Trp Arg Arg Cys Gln Lys Cys Val Trp Lys Phe Leu Glu Lys Pro Glu 
                165                 170                 175     


Ser Ser Cys Pro Ala Arg Val Val Ala Val Leu Ser Phe Leu Leu Ile 
            180                 185                 190         


Leu Val Ser Ser Val Val Met Cys Met Gly Thr Ile Pro Glu Leu Gln 
        195                 200                 205             


Val Leu Asp Ala Glu Gly Asn Arg Val Glu His Pro Thr Leu Glu Asn 
    210                 215                 220                 


Val Glu Thr Ala Cys Ile Gly Trp Phe Thr Leu Glu Tyr Leu Leu Arg 
225                 230                 235                 240 


Leu Phe Ser Ser Pro Asn Lys Leu His Phe Ala Leu Ser Phe Met Asn 
                245                 250                 255     


Ile Val Asp Val Leu Ala Ile Leu Pro Phe Tyr Val Ser Leu Thr Leu 
            260                 265                 270         


Thr His Leu Gly Ala Arg Met Met Glu Leu Thr Asn Val Gln Gln Ala 
        275                 280                 285             


Val Gln Ala Leu Arg Ile Met Arg Ile Ala Arg Ile Phe Lys Leu Ala 
    290                 295                 300                 


Arg His Ser Ser Gly Leu Gln Thr Leu Thr Tyr Ala Leu Lys Arg Ser 
305                 310                 315                 320 


Phe Lys Glu Leu Gly Leu Leu Leu Met Tyr Leu Ala Val Gly Ile Phe 
                325                 330                 335     


Val Phe Ser Ala Leu Gly Tyr Thr Met Glu Gln Ser His Pro Glu Thr 
            340                 345                 350         


Leu Phe Lys Ser Ile Pro Gln Ser Phe Trp Trp Ala Ile Ile Thr Met 
        355                 360                 365             


Thr Thr Val Gly Tyr Gly Asp Ile Tyr Pro Lys Thr Thr Leu Gly Lys 
    370                 375                 380                 


Leu Asn Ala Ala Ile Ser Phe Leu Cys Gly Val Ile Ala Ile Ala Leu 
385                 390                 395                 400 


Pro Ile His Pro Ile Ile Asn Asn Phe Val Arg Tyr Tyr Asn Lys Gln 
                405                 410                 415     


Arg Val Leu Glu Thr Ala Ala Lys His Glu Leu Glu Leu Met Glu Leu 
            420                 425                 430         


Asn Ser Ser Ser Gly Gly Glu Gly Lys Thr Gly Gly Ser Arg Ser Asp 
        435                 440                 445             


Leu Asp Asn Leu Pro Pro Glu Pro Ala Gly Lys Glu Ala Pro Ser Cys 
    450                 455                 460                 


Ser Ser Arg Leu Lys Leu Ser His Ser Asp Thr Phe Ile Pro Leu Leu 
465                 470                 475                 480 


Thr Glu Glu Lys His His Arg Thr Arg Leu Gln Ser Cys Lys 
                485                 490                 


<210> 39
<211> 513
<212> PRT
<213> Homo sapiens

<400> 39
Met Thr Leu Leu Pro Gly Asp Asn Ser Asp Tyr Asp Tyr Ser Ala Leu 
1               5                   10                  15      


Ser Cys Thr Ser Asp Ala Ser Phe His Pro Ala Phe Leu Pro Gln Arg 
            20                  25                  30          


Gln Ala Ile Lys Gly Ala Phe Tyr Arg Arg Ala Gln Arg Leu Arg Pro 
        35                  40                  45              


Gln Asp Glu Pro Arg Gln Gly Cys Gln Pro Glu Asp Arg Arg Arg Arg 
    50                  55                  60                  


Ile Ile Ile Asn Val Gly Gly Ile Lys Tyr Ser Leu Pro Trp Thr Thr 
65                  70                  75                  80  


Leu Asp Glu Phe Pro Leu Thr Arg Leu Gly Gln Leu Lys Ala Cys Thr 
                85                  90                  95      


Asn Phe Asp Asp Ile Leu Asn Val Cys Asp Asp Tyr Asp Val Thr Cys 
            100                 105                 110         


Asn Glu Phe Phe Phe Asp Arg Asn Pro Gly Ala Phe Gly Thr Ile Leu 
        115                 120                 125             


Thr Phe Leu Arg Ala Gly Lys Leu Arg Leu Leu Arg Glu Met Cys Ala 
    130                 135                 140                 


Leu Ser Phe Gln Glu Glu Leu Leu Tyr Trp Gly Ile Ala Glu Asp His 
145                 150                 155                 160 


Leu Asp Gly Cys Cys Lys Arg Arg Tyr Leu Gln Lys Ile Glu Glu Phe 
                165                 170                 175     


Ala Glu Met Val Glu Arg Glu Glu Glu Asp Asp Ala Leu Asp Ser Glu 
            180                 185                 190         


Gly Arg Asp Ser Glu Gly Pro Ala Glu Gly Glu Gly Arg Leu Gly Arg 
        195                 200                 205             


Cys Met Arg Arg Leu Arg Asp Met Val Glu Arg Pro His Ser Gly Leu 
    210                 215                 220                 


Pro Gly Lys Val Phe Ala Cys Leu Ser Val Leu Phe Val Thr Val Thr 
225                 230                 235                 240 


Ala Val Asn Leu Ser Val Ser Thr Leu Pro Ser Leu Arg Glu Glu Glu 
                245                 250                 255     


Glu Gln Gly His Cys Ser Gln Met Cys His Asn Val Phe Ile Val Glu 
            260                 265                 270         


Ser Val Cys Val Gly Trp Phe Ser Leu Glu Phe Leu Leu Arg Leu Ile 
        275                 280                 285             


Gln Ala Pro Ser Lys Phe Ala Phe Leu Arg Ser Pro Leu Thr Leu Ile 
    290                 295                 300                 


Asp Leu Val Ala Ile Leu Pro Tyr Tyr Ile Thr Leu Leu Val Asp Gly 
305                 310                 315                 320 


Ala Ala Ala Gly Arg Arg Lys Pro Gly Ala Gly Asn Ser Tyr Leu Asp 
                325                 330                 335     


Lys Val Gly Leu Val Leu Arg Val Leu Arg Ala Leu Arg Ile Leu Tyr 
            340                 345                 350         


Val Met Arg Leu Ala Arg His Ser Leu Gly Leu Gln Thr Leu Gly Leu 
        355                 360                 365             


Thr Ala Arg Arg Cys Thr Arg Glu Phe Gly Leu Leu Leu Leu Phe Leu 
    370                 375                 380                 


Cys Val Ala Ile Ala Leu Phe Ala Pro Leu Leu Tyr Val Ile Glu Asn 
385                 390                 395                 400 


Glu Met Ala Asp Ser Pro Glu Phe Thr Ser Ile Pro Ala Cys Tyr Trp 
                405                 410                 415     


Trp Ala Val Ile Thr Met Thr Thr Val Gly Tyr Gly Asp Met Val Pro 
            420                 425                 430         


Arg Ser Thr Pro Gly Gln Val Val Ala Leu Ser Ser Ile Leu Ser Gly 
        435                 440                 445             


Ile Leu Leu Met Ala Phe Pro Val Thr Ser Ile Phe His Thr Phe Ser 
    450                 455                 460                 


Arg Ser Tyr Leu Glu Leu Lys Gln Glu Gln Glu Arg Val Met Phe Arg 
465                 470                 475                 480 


Arg Ala Gln Phe Leu Ile Lys Thr Lys Ser Gln Leu Ser Val Ser Gln 
                485                 490                 495     


Asp Ser Asp Ile Leu Phe Gly Ser Ala Ser Ser Asp Thr Arg Asp Asn 
            500                 505                 510         


Asn 
    


<210> 40
<211> 466
<212> PRT
<213> Homo sapiens

<400> 40
Met Glu Pro Trp Pro Cys Ser Pro Gly Gly Gly Gly Gly Thr Arg Ala 
1               5                   10                  15      


Arg His Val Ile Ile Asn Val Gly Gly Cys Arg Val Arg Leu Ala Trp 
            20                  25                  30          


Ala Ala Leu Ala Arg Cys Pro Leu Ala Arg Leu Glu Arg Leu Arg Ala 
        35                  40                  45              


Cys Arg Gly His Asp Asp Leu Leu Arg Val Cys Asp Asp Tyr Asp Val 
    50                  55                  60                  


Ser Arg Asp Glu Phe Phe Phe Asp Arg Ser Pro Cys Ala Phe Arg Ala 
65                  70                  75                  80  


Ile Val Ala Leu Leu Arg Ala Gly Lys Leu Arg Leu Leu Arg Gly Pro 
                85                  90                  95      


Cys Ala Leu Ala Phe Arg Asp Glu Leu Ala Tyr Trp Gly Ile Asp Glu 
            100                 105                 110         


Ala Arg Leu Glu Arg Cys Cys Leu Arg Arg Leu Arg Arg Arg Glu Glu 
        115                 120                 125             


Glu Ala Ala Glu Ala Arg Ala Gly Pro Thr Glu Arg Gly Ala Gln Gly 
    130                 135                 140                 


Ser Pro Ala Arg Ala Leu Gly Pro Arg Gly Arg Leu Gln Arg Gly Arg 
145                 150                 155                 160 


Arg Arg Leu Arg Asp Val Val Asp Asn Pro His Ser Gly Leu Ala Gly 
                165                 170                 175     


Lys Leu Phe Ala Cys Val Ser Val Ser Phe Val Ala Val Thr Ala Val 
            180                 185                 190         


Gly Leu Cys Leu Ser Thr Met Pro Asp Ile Arg Ala Glu Glu Glu Arg 
        195                 200                 205             


Gly Glu Cys Ser Pro Lys Cys Arg Ser Leu Phe Val Leu Glu Thr Val 
    210                 215                 220                 


Cys Val Ala Trp Phe Ser Phe Glu Phe Leu Leu Arg Ser Leu Gln Ala 
225                 230                 235                 240 


Glu Ser Lys Cys Ala Phe Leu Arg Ala Pro Leu Asn Ile Ile Asp Ile 
                245                 250                 255     


Leu Ala Leu Leu Pro Phe Tyr Val Ser Leu Leu Leu Gly Leu Ala Ala 
            260                 265                 270         


Gly Pro Gly Gly Thr Lys Leu Leu Glu Arg Ala Gly Leu Val Leu Arg 
        275                 280                 285             


Leu Leu Arg Ala Leu Arg Val Leu Tyr Val Met Arg Leu Ala Arg His 
    290                 295                 300                 


Ser Leu Gly Leu Arg Ser Leu Gly Leu Thr Met Arg Arg Cys Ala Arg 
305                 310                 315                 320 


Glu Phe Gly Leu Leu Leu Leu Phe Leu Cys Val Ala Met Ala Leu Phe 
                325                 330                 335     


Ala Pro Leu Val His Leu Ala Glu Arg Glu Leu Gly Ala Arg Arg Asp 
            340                 345                 350         


Phe Ser Ser Val Pro Ala Ser Tyr Trp Trp Ala Val Ile Ser Met Thr 
        355                 360                 365             


Thr Val Gly Tyr Gly Asp Met Val Pro Arg Ser Leu Pro Gly Gln Val 
    370                 375                 380                 


Val Ala Leu Ser Ser Ile Leu Ser Gly Ile Leu Leu Met Ala Phe Pro 
385                 390                 395                 400 


Val Thr Ser Ile Phe His Thr Phe Ser Arg Ser Tyr Ser Glu Leu Lys 
                405                 410                 415     


Glu Gln Gln Gln Arg Ala Ala Ser Pro Glu Pro Ala Leu Gln Glu Asp 
            420                 425                 430         


Ser Thr His Ser Ala Thr Ala Thr Glu Asp Ser Ser Gln Gly Pro Asp 
        435                 440                 445             


Ser Ala Gly Leu Ala Asp Asp Ser Ala Asp Ala Leu Trp Val Arg Ala 
    450                 455                 460                 


Gly Arg 
465     


<210> 41
<211> 436
<212> PRT
<213> Homo sapiens

<400> 41
Met Thr Phe Gly Arg Ser Gly Ala Ala Ser Val Val Leu Asn Val Gly 
1               5                   10                  15      


Gly Ala Arg Tyr Ser Leu Ser Arg Glu Leu Leu Lys Asp Phe Pro Leu 
            20                  25                  30          


Arg Arg Val Ser Arg Leu His Gly Cys Arg Ser Glu Arg Asp Val Leu 
        35                  40                  45              


Glu Val Cys Asp Asp Tyr Asp Arg Glu Arg Asn Glu Tyr Phe Phe Asp 
    50                  55                  60                  


Arg His Ser Glu Ala Phe Gly Phe Ile Leu Leu Tyr Val Arg Gly His 
65                  70                  75                  80  


Gly Lys Leu Arg Phe Ala Pro Arg Met Cys Glu Leu Ser Phe Tyr Asn 
                85                  90                  95      


Glu Met Ile Tyr Trp Gly Leu Glu Gly Ala His Leu Glu Tyr Cys Cys 
            100                 105                 110         


Gln Arg Arg Leu Asp Asp Arg Met Ser Asp Thr Tyr Thr Phe Tyr Ser 
        115                 120                 125             


Ala Asp Glu Pro Gly Val Leu Gly Arg Asp Glu Ala Arg Pro Gly Gly 
    130                 135                 140                 


Ala Glu Ala Ala Pro Ser Arg Arg Trp Leu Glu Arg Met Arg Arg Thr 
145                 150                 155                 160 


Phe Glu Glu Pro Thr Ser Ser Leu Ala Ala Gln Ile Leu Ala Ser Val 
                165                 170                 175     


Ser Val Val Phe Val Ile Val Ser Met Val Val Leu Cys Ala Ser Thr 
            180                 185                 190         


Leu Pro Asp Trp Arg Asn Ala Ala Ala Asp Asn Arg Ser Leu Asp Asp 
        195                 200                 205             


Arg Ser Arg Tyr Ser Ala Gly Pro Gly Arg Glu Pro Ser Gly Ile Ile 
    210                 215                 220                 


Glu Ala Ile Cys Ile Gly Trp Phe Thr Ala Glu Cys Ile Val Arg Phe 
225                 230                 235                 240 


Ile Val Ser Lys Asn Lys Cys Glu Phe Val Lys Arg Pro Leu Asn Ile 
                245                 250                 255     


Ile Asp Leu Leu Ala Ile Thr Pro Tyr Tyr Ile Ser Val Leu Met Thr 
            260                 265                 270         


Val Phe Thr Gly Glu Asn Ser Gln Leu Gln Arg Ala Gly Val Thr Leu 
        275                 280                 285             


Arg Val Leu Arg Met Met Arg Ile Phe Trp Val Ile Lys Leu Ala Arg 
    290                 295                 300                 


His Phe Ile Gly Leu Gln Thr Leu Gly Leu Thr Leu Lys Arg Cys Tyr 
305                 310                 315                 320 


Arg Glu Met Val Met Leu Leu Val Phe Ile Cys Val Ala Met Ala Ile 
                325                 330                 335     


Phe Ser Ala Leu Ser Gln Leu Leu Glu His Gly Leu Asp Leu Glu Thr 
            340                 345                 350         


Ser Asn Lys Asp Phe Thr Ser Ile Pro Ala Ala Cys Trp Trp Val Ile 
        355                 360                 365             


Ile Ser Met Thr Thr Val Gly Tyr Gly Asp Met Tyr Pro Ile Thr Val 
    370                 375                 380                 


Pro Gly Arg Ile Leu Gly Gly Val Cys Val Val Ser Gly Ile Val Leu 
385                 390                 395                 400 


Leu Ala Leu Pro Ile Thr Phe Ile Tyr His Ser Phe Val Gln Cys Tyr 
                405                 410                 415     


His Glu Leu Lys Phe Arg Ser Ala Arg Tyr Ser Arg Ser Leu Ser Thr 
            420                 425                 430         


Glu Phe Leu Asn 
        435     


<210> 42
<211> 519
<212> PRT
<213> Homo sapiens

<400> 42
Met Pro Met Pro Ser Arg Asp Gly Gly Leu His Pro Arg His His His 
1               5                   10                  15      


Tyr Gly Ser His Ser Pro Trp Ser Gln Leu Leu Ser Ser Pro Met Glu 
            20                  25                  30          


Thr Pro Ser Ile Lys Gly Leu Tyr Tyr Arg Arg Val Arg Lys Val Gly 
        35                  40                  45              


Ala Leu Asp Ala Ser Pro Val Asp Leu Lys Lys Glu Ile Leu Ile Asn 
    50                  55                  60                  


Val Gly Gly Arg Arg Tyr Leu Leu Pro Trp Ser Thr Leu Asp Arg Phe 
65                  70                  75                  80  


Pro Leu Ser Arg Leu Ser Lys Leu Arg Leu Cys Arg Ser Tyr Glu Glu 
                85                  90                  95      


Ile Val Gln Leu Cys Asp Asp Tyr Asp Glu Asp Ser Gln Glu Phe Phe 
            100                 105                 110         


Phe Asp Arg Ser Pro Ser Ala Phe Gly Val Ile Val Ser Phe Leu Ala 
        115                 120                 125             


Ala Gly Lys Leu Val Leu Leu Gln Glu Met Cys Ala Leu Ser Phe Gln 
    130                 135                 140                 


Glu Glu Leu Ala Tyr Trp Gly Ile Glu Glu Ala His Leu Glu Arg Cys 
145                 150                 155                 160 


Cys Leu Arg Lys Leu Leu Arg Lys Leu Glu Glu Leu Glu Glu Leu Ala 
                165                 170                 175     


Lys Leu His Arg Glu Asp Val Leu Arg Gln Gln Arg Glu Thr Arg Arg 
            180                 185                 190         


Pro Ala Ser His Ser Ser Arg Trp Gly Leu Cys Met Asn Arg Leu Arg 
        195                 200                 205             


Glu Met Val Glu Asn Pro Gln Ser Gly Leu Pro Gly Lys Val Phe Ala 
    210                 215                 220                 


Cys Leu Ser Ile Leu Phe Val Ala Thr Thr Ala Val Ser Leu Cys Val 
225                 230                 235                 240 


Ser Thr Met Pro Asp Leu Arg Ala Glu Glu Asp Gln Gly Glu Cys Ser 
                245                 250                 255     


Arg Lys Cys Tyr Tyr Ile Phe Ile Val Glu Thr Ile Cys Val Ala Trp 
            260                 265                 270         


Phe Ser Leu Glu Phe Cys Leu Arg Phe Val Gln Ala Gln Asp Lys Cys 
        275                 280                 285             


Gln Phe Phe Gln Gly Pro Leu Asn Ile Ile Asp Ile Leu Ala Ile Ser 
    290                 295                 300                 


Pro Tyr Tyr Val Ser Leu Ala Val Ser Glu Glu Pro Pro Glu Asp Gly 
305                 310                 315                 320 


Glu Arg Pro Ser Gly Ser Ser Tyr Leu Glu Lys Val Gly Leu Val Leu 
                325                 330                 335     


Arg Val Leu Arg Ala Leu Arg Ile Leu Tyr Val Met Arg Leu Ala Arg 
            340                 345                 350         


His Ser Leu Gly Leu Gln Thr Leu Gly Leu Thr Val Arg Arg Cys Thr 
        355                 360                 365             


Arg Glu Phe Gly Leu Leu Leu Leu Phe Leu Ala Val Ala Ile Thr Leu 
    370                 375                 380                 


Phe Ser Pro Leu Val Tyr Val Ala Glu Lys Glu Ser Gly Arg Val Leu 
385                 390                 395                 400 


Glu Phe Thr Ser Ile Pro Ala Ser Tyr Trp Trp Ala Ile Ile Ser Met 
                405                 410                 415     


Thr Thr Val Gly Tyr Gly Asp Met Val Pro Arg Ser Val Pro Gly Gln 
            420                 425                 430         


Met Val Ala Leu Ser Ser Ile Leu Ser Gly Ile Leu Ile Met Ala Phe 
        435                 440                 445             


Pro Ala Thr Ser Ile Phe His Thr Phe Ser His Ser Tyr Leu Glu Leu 
    450                 455                 460                 


Lys Lys Glu Gln Glu Gln Leu Gln Ala Arg Leu Arg His Leu Gln Asn 
465                 470                 475                 480 


Thr Gly Pro Ala Ser Glu Cys Glu Leu Leu Asp Pro His Val Ala Ser 
                485                 490                 495     


Glu His Glu Leu Met Asn Asp Val Asn Asp Leu Ile Leu Glu Gly Pro 
            500                 505                 510         


Ala Leu Pro Ile Met His Met 
        515                 


<210> 43
<211> 676
<212> PRT
<213> Homo sapiens

<400> 43
Met Ala Ala Ala Ser Ser Pro Pro Arg Ala Glu Arg Lys Arg Trp Gly 
1               5                   10                  15      


Trp Gly Arg Leu Pro Gly Ala Arg Arg Gly Ser Ala Gly Leu Ala Lys 
            20                  25                  30          


Lys Cys Pro Phe Ser Leu Glu Leu Ala Glu Gly Gly Pro Ala Gly Gly 
        35                  40                  45              


Ala Leu Tyr Ala Pro Ile Ala Pro Gly Ala Pro Gly Pro Ala Pro Pro 
    50                  55                  60                  


Ala Ser Pro Ala Ala Pro Ala Ala Pro Pro Val Ala Ser Asp Leu Gly 
65                  70                  75                  80  


Pro Arg Pro Pro Val Ser Leu Asp Pro Arg Val Ser Ile Tyr Ser Thr 
                85                  90                  95      


Arg Arg Pro Val Leu Ala Arg Thr His Val Gln Gly Arg Val Tyr Asn 
            100                 105                 110         


Phe Leu Glu Arg Pro Thr Gly Trp Lys Cys Phe Val Tyr His Phe Ala 
        115                 120                 125             


Val Phe Leu Ile Val Leu Val Cys Leu Ile Phe Ser Val Leu Ser Thr 
    130                 135                 140                 


Ile Glu Gln Tyr Ala Ala Leu Ala Thr Gly Thr Leu Phe Trp Met Glu 
145                 150                 155                 160 


Ile Val Leu Val Val Phe Phe Gly Thr Glu Tyr Val Val Arg Leu Trp 
                165                 170                 175     


Ser Ala Gly Cys Arg Ser Lys Tyr Val Gly Leu Trp Gly Arg Leu Arg 
            180                 185                 190         


Phe Ala Arg Lys Pro Ile Ser Ile Ile Asp Leu Ile Val Val Val Ala 
        195                 200                 205             


Ser Met Val Val Leu Cys Val Gly Ser Lys Gly Gln Val Phe Ala Thr 
    210                 215                 220                 


Ser Ala Ile Arg Gly Ile Arg Phe Leu Gln Ile Leu Arg Met Leu His 
225                 230                 235                 240 


Val Asp Arg Gln Gly Gly Thr Trp Arg Leu Leu Gly Ser Val Val Phe 
                245                 250                 255     


Ile His Arg Gln Glu Leu Ile Thr Thr Leu Tyr Ile Gly Phe Leu Gly 
            260                 265                 270         


Leu Ile Phe Ser Ser Tyr Phe Val Tyr Leu Ala Glu Lys Asp Ala Val 
        275                 280                 285             


Asn Glu Ser Gly Arg Val Glu Phe Gly Ser Tyr Ala Asp Ala Leu Trp 
    290                 295                 300                 


Trp Gly Val Val Thr Val Thr Thr Ile Gly Tyr Gly Asp Lys Val Pro 
305                 310                 315                 320 


Gln Thr Trp Val Gly Lys Thr Ile Ala Ser Cys Phe Ser Val Phe Ala 
                325                 330                 335     


Ile Ser Phe Phe Ala Leu Pro Ala Gly Ile Leu Gly Ser Gly Phe Ala 
            340                 345                 350         


Leu Lys Val Gln Gln Lys Gln Arg Gln Lys His Phe Asn Arg Gln Ile 
        355                 360                 365             


Pro Ala Ala Ala Ser Leu Ile Gln Thr Ala Trp Arg Cys Tyr Ala Ala 
    370                 375                 380                 


Glu Asn Pro Asp Ser Ser Thr Trp Lys Ile Tyr Ile Arg Lys Ala Pro 
385                 390                 395                 400 


Arg Ser His Thr Leu Leu Ser Pro Ser Pro Lys Pro Lys Lys Ser Val 
                405                 410                 415     


Val Val Lys Lys Lys Lys Phe Lys Leu Asp Lys Asp Asn Gly Val Thr 
            420                 425                 430         


Pro Gly Glu Lys Met Leu Thr Val Pro His Ile Thr Cys Asp Pro Pro 
        435                 440                 445             


Glu Glu Arg Arg Leu Asp His Phe Ser Val Asp Gly Tyr Asp Ser Ser 
    450                 455                 460                 


Val Arg Lys Ser Pro Thr Leu Leu Glu Val Ser Met Pro His Phe Met 
465                 470                 475                 480 


Arg Thr Asn Ser Phe Ala Glu Asp Leu Asp Leu Glu Gly Glu Thr Leu 
                485                 490                 495     


Leu Thr Pro Ile Thr His Ile Ser Gln Leu Arg Glu His His Arg Ala 
            500                 505                 510         


Thr Ile Lys Val Ile Arg Arg Met Gln Tyr Phe Val Ala Lys Lys Lys 
        515                 520                 525             


Phe Gln Gln Ala Arg Lys Pro Tyr Asp Val Arg Asp Val Ile Glu Gln 
    530                 535                 540                 


Tyr Ser Gln Gly His Leu Asn Leu Met Val Arg Ile Lys Glu Leu Gln 
545                 550                 555                 560 


Arg Arg Leu Asp Gln Ser Ile Gly Lys Pro Ser Leu Phe Ile Ser Val 
                565                 570                 575     


Ser Glu Lys Ser Lys Asp Arg Gly Ser Asn Thr Ile Gly Ala Arg Leu 
            580                 585                 590         


Asn Arg Val Glu Asp Lys Val Thr Gln Leu Asp Gln Arg Leu Ala Leu 
        595                 600                 605             


Ile Thr Asp Met Leu His Gln Leu Leu Ser Leu His Gly Gly Ser Thr 
    610                 615                 620                 


Pro Gly Ser Gly Gly Pro Pro Arg Glu Gly Gly Ala His Ile Thr Gln 
625                 630                 635                 640 


Pro Cys Gly Ser Gly Gly Ser Val Asp Pro Glu Leu Phe Leu Pro Ser 
                645                 650                 655     


Asn Thr Leu Pro Thr Tyr Glu Gln Leu Thr Val Pro Arg Arg Gly Pro 
            660                 665                 670         


Asp Glu Gly Ser 
        675     


<210> 44
<211> 872
<212> PRT
<213> Homo sapiens

<400> 44
Met Val Gln Lys Ser Arg Asn Gly Gly Val Tyr Pro Gly Pro Ser Gly 
1               5                   10                  15      


Glu Lys Lys Leu Lys Val Gly Phe Val Gly Leu Asp Pro Gly Ala Pro 
            20                  25                  30          


Asp Ser Thr Arg Asp Gly Ala Leu Leu Ile Ala Gly Ser Glu Ala Pro 
        35                  40                  45              


Lys Arg Gly Ser Ile Leu Ser Lys Pro Arg Ala Gly Gly Ala Gly Ala 
    50                  55                  60                  


Gly Lys Pro Pro Lys Arg Asn Ala Phe Tyr Arg Lys Leu Gln Asn Phe 
65                  70                  75                  80  


Leu Tyr Asn Val Leu Glu Arg Pro Arg Gly Trp Ala Phe Ile Tyr His 
                85                  90                  95      


Ala Tyr Val Phe Leu Leu Val Phe Ser Cys Leu Val Leu Ser Val Phe 
            100                 105                 110         


Ser Thr Ile Lys Glu Tyr Glu Lys Ser Ser Glu Gly Ala Leu Tyr Ile 
        115                 120                 125             


Leu Glu Ile Val Thr Ile Val Val Phe Gly Val Glu Tyr Phe Val Arg 
    130                 135                 140                 


Ile Trp Ala Ala Gly Cys Cys Cys Arg Tyr Arg Gly Trp Arg Gly Arg 
145                 150                 155                 160 


Leu Lys Phe Ala Arg Lys Pro Phe Cys Val Ile Asp Ile Met Val Leu 
                165                 170                 175     


Ile Ala Ser Ile Ala Val Leu Ala Ala Gly Ser Gln Gly Asn Val Phe 
            180                 185                 190         


Ala Thr Ser Ala Leu Arg Ser Leu Arg Phe Leu Gln Ile Leu Arg Met 
        195                 200                 205             


Ile Arg Met Asp Arg Arg Gly Gly Thr Trp Lys Leu Leu Gly Ser Val 
    210                 215                 220                 


Val Tyr Ala His Ser Lys Glu Leu Val Thr Ala Trp Tyr Ile Gly Phe 
225                 230                 235                 240 


Leu Cys Leu Ile Leu Ala Ser Phe Leu Val Tyr Leu Ala Glu Lys Gly 
                245                 250                 255     


Glu Asn Asp His Phe Asp Thr Tyr Ala Asp Ala Leu Trp Trp Gly Leu 
            260                 265                 270         


Ile Thr Leu Thr Thr Ile Gly Tyr Gly Asp Lys Tyr Pro Gln Thr Trp 
        275                 280                 285             


Asn Gly Arg Leu Leu Ala Ala Thr Phe Thr Leu Ile Gly Val Ser Phe 
    290                 295                 300                 


Phe Ala Leu Pro Ala Gly Ile Leu Gly Ser Gly Phe Ala Leu Lys Val 
305                 310                 315                 320 


Gln Glu Gln His Arg Gln Lys His Phe Glu Lys Arg Arg Asn Pro Ala 
                325                 330                 335     


Ala Gly Leu Ile Gln Ser Ala Trp Arg Phe Tyr Ala Thr Asn Leu Ser 
            340                 345                 350         


Arg Thr Asp Leu His Ser Thr Trp Gln Tyr Tyr Glu Arg Thr Val Thr 
        355                 360                 365             


Val Pro Met Tyr Ser Ser Gln Thr Gln Thr Tyr Gly Ala Ser Arg Leu 
    370                 375                 380                 


Ile Pro Pro Leu Asn Gln Leu Glu Leu Leu Arg Asn Leu Lys Ser Lys 
385                 390                 395                 400 


Ser Gly Leu Ala Phe Arg Lys Asp Pro Pro Pro Glu Pro Ser Pro Ser 
                405                 410                 415     


Lys Gly Ser Pro Cys Arg Gly Pro Leu Cys Gly Cys Cys Pro Gly Arg 
            420                 425                 430         


Ser Ser Gln Lys Val Ser Leu Lys Asp Arg Val Phe Ser Ser Pro Arg 
        435                 440                 445             


Gly Val Ala Ala Lys Gly Lys Gly Ser Pro Gln Ala Gln Thr Val Arg 
    450                 455                 460                 


Arg Ser Pro Ser Ala Asp Gln Ser Leu Glu Asp Ser Pro Ser Lys Val 
465                 470                 475                 480 


Pro Lys Ser Trp Ser Phe Gly Asp Arg Ser Arg Ala Arg Gln Ala Phe 
                485                 490                 495     


Arg Ile Lys Gly Ala Ala Ser Arg Gln Asn Ser Glu Glu Ala Ser Leu 
            500                 505                 510         


Pro Gly Glu Asp Ile Val Asp Asp Lys Ser Cys Pro Cys Glu Phe Val 
        515                 520                 525             


Thr Glu Asp Leu Thr Pro Gly Leu Lys Val Ser Ile Arg Ala Val Cys 
    530                 535                 540                 


Val Met Arg Phe Leu Val Ser Lys Arg Lys Phe Lys Glu Ser Leu Arg 
545                 550                 555                 560 


Pro Tyr Asp Val Met Asp Val Ile Glu Gln Tyr Ser Ala Gly His Leu 
                565                 570                 575     


Asp Met Leu Ser Arg Ile Lys Ser Leu Gln Ser Arg Val Asp Gln Ile 
            580                 585                 590         


Val Gly Arg Gly Pro Ala Ile Thr Asp Lys Asp Arg Thr Lys Gly Pro 
        595                 600                 605             


Ala Glu Ala Glu Leu Pro Glu Asp Pro Ser Met Met Gly Arg Leu Gly 
    610                 615                 620                 


Lys Val Glu Lys Gln Val Leu Ser Met Glu Lys Lys Leu Asp Phe Leu 
625                 630                 635                 640 


Val Asn Ile Tyr Met Gln Arg Met Gly Ile Pro Pro Thr Glu Thr Glu 
                645                 650                 655     


Ala Tyr Phe Gly Ala Lys Glu Pro Glu Pro Ala Pro Pro Tyr His Ser 
            660                 665                 670         


Pro Glu Asp Ser Arg Glu His Val Asp Arg His Gly Cys Ile Val Lys 
        675                 680                 685             


Ile Val Arg Ser Ser Ser Ser Thr Gly Gln Lys Asn Phe Ser Ala Pro 
    690                 695                 700                 


Pro Ala Ala Pro Pro Val Gln Cys Pro Pro Ser Thr Ser Trp Gln Pro 
705                 710                 715                 720 


Gln Ser His Pro Arg Gln Gly His Gly Thr Ser Pro Val Gly Asp His 
                725                 730                 735     


Gly Ser Leu Val Arg Ile Pro Pro Pro Pro Ala His Glu Arg Ser Leu 
            740                 745                 750         


Ser Ala Tyr Gly Gly Gly Asn Arg Ala Ser Met Glu Phe Leu Arg Gln 
        755                 760                 765             


Glu Asp Thr Pro Gly Cys Arg Pro Pro Glu Gly Asn Leu Arg Asp Ser 
    770                 775                 780                 


Asp Thr Ser Ile Ser Ile Pro Ser Val Asp His Glu Glu Leu Glu Arg 
785                 790                 795                 800 


Ser Phe Ser Gly Phe Ser Ile Ser Gln Ser Lys Glu Asn Leu Asp Ala 
                805                 810                 815     


Leu Asn Ser Cys Tyr Ala Ala Val Ala Pro Cys Ala Lys Val Arg Pro 
            820                 825                 830         


Tyr Ile Ala Glu Gly Glu Ser Asp Thr Asp Ser Asp Leu Cys Thr Pro 
        835                 840                 845             


Cys Gly Pro Pro Pro Arg Ser Ala Thr Gly Glu Gly Pro Phe Gly Asp 
    850                 855                 860                 


Val Gly Trp Ala Gly Pro Arg Lys 
865                 870         


<210> 45
<211> 872
<212> PRT
<213> Homo sapiens

<400> 45
Met Gly Leu Lys Ala Arg Arg Ala Ala Gly Ala Ala Gly Gly Gly Gly 
1               5                   10                  15      


Asp Gly Gly Gly Gly Gly Gly Gly Ala Ala Asn Pro Ala Gly Gly Asp 
            20                  25                  30          


Ala Ala Ala Ala Gly Asp Glu Glu Arg Lys Val Gly Leu Ala Pro Gly 
        35                  40                  45              


Asp Val Glu Gln Val Thr Leu Ala Leu Gly Ala Gly Ala Asp Lys Asp 
    50                  55                  60                  


Gly Thr Leu Leu Leu Glu Gly Gly Gly Arg Asp Glu Gly Gln Arg Arg 
65                  70                  75                  80  


Thr Pro Gln Gly Ile Gly Leu Leu Ala Lys Thr Pro Leu Ser Arg Pro 
                85                  90                  95      


Val Lys Arg Asn Asn Ala Lys Tyr Arg Arg Ile Gln Thr Leu Ile Tyr 
            100                 105                 110         


Asp Ala Leu Glu Arg Pro Arg Gly Trp Ala Leu Leu Tyr His Ala Leu 
        115                 120                 125             


Val Phe Leu Ile Val Leu Gly Cys Leu Ile Leu Ala Val Leu Thr Thr 
    130                 135                 140                 


Phe Lys Glu Tyr Glu Thr Val Ser Gly Asp Trp Leu Leu Leu Leu Glu 
145                 150                 155                 160 


Thr Phe Ala Ile Phe Ile Phe Gly Ala Glu Phe Ala Leu Arg Ile Trp 
                165                 170                 175     


Ala Ala Gly Cys Cys Cys Arg Tyr Lys Gly Trp Arg Gly Arg Leu Lys 
            180                 185                 190         


Phe Ala Arg Lys Pro Leu Cys Met Leu Asp Ile Phe Val Leu Ile Ala 
        195                 200                 205             


Ser Val Pro Val Val Ala Val Gly Asn Gln Gly Asn Val Leu Ala Thr 
    210                 215                 220                 


Ser Leu Arg Ser Leu Arg Phe Leu Gln Ile Leu Arg Met Leu Arg Met 
225                 230                 235                 240 


Asp Arg Arg Gly Gly Thr Trp Lys Leu Leu Gly Ser Ala Ile Cys Ala 
                245                 250                 255     


His Ser Lys Glu Leu Ile Thr Ala Trp Tyr Ile Gly Phe Leu Thr Leu 
            260                 265                 270         


Ile Leu Ser Ser Phe Leu Val Tyr Leu Val Glu Lys Asp Val Pro Glu 
        275                 280                 285             


Val Asp Ala Gln Gly Glu Glu Met Lys Glu Glu Phe Glu Thr Tyr Ala 
    290                 295                 300                 


Asp Ala Leu Trp Trp Gly Leu Ile Thr Leu Ala Thr Ile Gly Tyr Gly 
305                 310                 315                 320 


Asp Lys Thr Pro Lys Thr Trp Glu Gly Arg Leu Ile Ala Ala Thr Phe 
                325                 330                 335     


Ser Leu Ile Gly Val Ser Phe Phe Ala Leu Pro Ala Gly Ile Leu Gly 
            340                 345                 350         


Ser Gly Leu Ala Leu Lys Val Gln Glu Gln His Arg Gln Lys His Phe 
        355                 360                 365             


Glu Lys Arg Arg Lys Pro Ala Ala Glu Leu Ile Gln Ala Ala Trp Arg 
    370                 375                 380                 


Tyr Tyr Ala Thr Asn Pro Asn Arg Ile Asp Leu Val Ala Thr Trp Arg 
385                 390                 395                 400 


Phe Tyr Glu Ser Val Val Ser Phe Pro Phe Phe Arg Lys Glu Gln Leu 
                405                 410                 415     


Glu Ala Ala Ser Ser Gln Lys Leu Gly Leu Leu Asp Arg Val Arg Leu 
            420                 425                 430         


Ser Asn Pro Arg Gly Ser Asn Thr Lys Gly Lys Leu Phe Thr Pro Leu 
        435                 440                 445             


Asn Val Asp Ala Ile Glu Glu Ser Pro Ser Lys Glu Pro Lys Pro Val 
    450                 455                 460                 


Gly Leu Asn Asn Lys Glu Arg Phe Arg Thr Ala Phe Arg Met Lys Ala 
465                 470                 475                 480 


Tyr Ala Phe Trp Gln Ser Ser Glu Asp Ala Gly Thr Gly Asp Pro Met 
                485                 490                 495     


Ala Glu Asp Arg Gly Tyr Gly Asn Asp Phe Pro Ile Glu Asp Met Ile 
            500                 505                 510         


Pro Thr Leu Lys Ala Ala Ile Arg Ala Val Arg Ile Leu Gln Phe Arg 
        515                 520                 525             


Leu Tyr Lys Lys Lys Phe Lys Glu Thr Leu Arg Pro Tyr Asp Val Lys 
    530                 535                 540                 


Asp Val Ile Glu Gln Tyr Ser Ala Gly His Leu Asp Met Leu Ser Arg 
545                 550                 555                 560 


Ile Lys Tyr Leu Gln Thr Arg Ile Asp Met Ile Phe Thr Pro Gly Pro 
                565                 570                 575     


Pro Ser Thr Pro Lys His Lys Lys Ser Gln Lys Gly Ser Ala Phe Thr 
            580                 585                 590         


Phe Pro Ser Gln Gln Ser Pro Arg Asn Glu Pro Tyr Val Ala Arg Pro 
        595                 600                 605             


Ser Thr Ser Glu Ile Glu Asp Gln Ser Met Met Gly Lys Phe Val Lys 
    610                 615                 620                 


Val Glu Arg Gln Val Gln Asp Met Gly Lys Lys Leu Asp Phe Leu Val 
625                 630                 635                 640 


Asp Met His Met Gln His Met Glu Arg Leu Gln Val Gln Val Thr Glu 
                645                 650                 655     


Tyr Tyr Pro Thr Lys Gly Thr Ser Ser Pro Ala Glu Ala Glu Lys Lys 
            660                 665                 670         


Glu Asp Asn Arg Tyr Ser Asp Leu Lys Thr Ile Ile Cys Asn Tyr Ser 
        675                 680                 685             


Glu Thr Gly Pro Pro Glu Pro Pro Tyr Ser Phe His Gln Val Thr Ile 
    690                 695                 700                 


Asp Lys Val Ser Pro Tyr Gly Phe Phe Ala His Asp Pro Val Asn Leu 
705                 710                 715                 720 


Pro Arg Gly Gly Pro Ser Ser Gly Lys Val Gln Ala Thr Pro Pro Ser 
                725                 730                 735     


Ser Ala Thr Thr Tyr Val Glu Arg Pro Thr Val Leu Pro Ile Leu Thr 
            740                 745                 750         


Leu Leu Asp Ser Arg Val Ser Cys His Ser Gln Ala Asp Leu Gln Gly 
        755                 760                 765             


Pro Tyr Ser Asp Arg Ile Ser Pro Arg Gln Arg Arg Ser Ile Thr Arg 
    770                 775                 780                 


Asp Ser Asp Thr Pro Leu Ser Leu Met Ser Val Asn His Glu Glu Leu 
785                 790                 795                 800 


Glu Arg Ser Pro Ser Gly Phe Ser Ile Ser Gln Asp Arg Asp Asp Tyr 
                805                 810                 815     


Val Phe Gly Pro Asn Gly Gly Ser Ser Trp Met Arg Glu Lys Arg Tyr 
            820                 825                 830         


Leu Ala Glu Gly Glu Thr Asp Thr Asp Thr Asp Pro Phe Thr Pro Ser 
        835                 840                 845             


Gly Ser Met Pro Leu Ser Ser Thr Gly Asp Gly Ile Ser Asp Ser Val 
    850                 855                 860                 


Trp Thr Pro Ser Asn Lys Pro Ile 
865                 870         


<210> 46
<211> 695
<212> PRT
<213> Homo sapiens

<400> 46
Met Ala Glu Ala Pro Pro Arg Arg Leu Gly Leu Gly Pro Pro Pro Gly 
1               5                   10                  15      


Asp Ala Pro Arg Ala Glu Leu Val Ala Leu Thr Ala Val Gln Ser Glu 
            20                  25                  30          


Gln Gly Glu Ala Gly Gly Gly Gly Ser Pro Arg Arg Leu Gly Leu Leu 
        35                  40                  45              


Gly Ser Pro Leu Pro Pro Gly Ala Pro Leu Pro Gly Pro Gly Ser Gly 
    50                  55                  60                  


Ser Gly Ser Ala Cys Gly Gln Arg Ser Ser Ala Ala His Lys Arg Tyr 
65                  70                  75                  80  


Arg Arg Leu Gln Asn Trp Val Tyr Asn Val Leu Glu Arg Pro Arg Gly 
                85                  90                  95      


Trp Ala Phe Val Tyr His Val Phe Ile Phe Leu Leu Val Phe Ser Cys 
            100                 105                 110         


Leu Val Leu Ser Val Leu Ser Thr Ile Gln Glu His Gln Glu Leu Ala 
        115                 120                 125             


Asn Glu Cys Leu Leu Ile Leu Glu Phe Val Met Ile Val Val Phe Gly 
    130                 135                 140                 


Leu Glu Tyr Ile Val Arg Val Trp Ser Ala Gly Cys Cys Cys Arg Tyr 
145                 150                 155                 160 


Arg Gly Trp Gln Gly Arg Phe Arg Phe Ala Arg Lys Pro Phe Cys Val 
                165                 170                 175     


Ile Asp Phe Ile Val Phe Val Ala Ser Val Ala Val Ile Ala Ala Gly 
            180                 185                 190         


Thr Gln Gly Asn Ile Phe Ala Thr Ser Ala Leu Arg Ser Met Arg Phe 
        195                 200                 205             


Leu Gln Ile Leu Arg Met Val Arg Met Asp Arg Arg Gly Gly Thr Trp 
    210                 215                 220                 


Lys Leu Leu Gly Ser Val Val Tyr Ala His Ser Lys Glu Leu Ile Thr 
225                 230                 235                 240 


Ala Trp Tyr Ile Gly Phe Leu Val Leu Ile Phe Ala Ser Phe Leu Val 
                245                 250                 255     


Tyr Leu Ala Glu Lys Asp Ala Asn Ser Asp Phe Ser Ser Tyr Ala Asp 
            260                 265                 270         


Ser Leu Trp Trp Gly Thr Ile Thr Leu Thr Thr Ile Gly Tyr Gly Asp 
        275                 280                 285             


Lys Thr Pro His Thr Trp Leu Gly Arg Val Leu Ala Ala Gly Phe Ala 
    290                 295                 300                 


Leu Leu Gly Ile Ser Phe Phe Ala Leu Pro Ala Gly Ile Leu Gly Ser 
305                 310                 315                 320 


Gly Phe Ala Leu Lys Val Gln Glu Gln His Arg Gln Lys His Phe Glu 
                325                 330                 335     


Lys Arg Arg Met Pro Ala Ala Asn Leu Ile Gln Ala Ala Trp Arg Leu 
            340                 345                 350         


Tyr Ser Thr Asp Met Ser Arg Ala Tyr Leu Thr Ala Thr Trp Tyr Tyr 
        355                 360                 365             


Tyr Asp Ser Ile Leu Pro Ser Phe Arg Glu Leu Ala Leu Leu Phe Glu 
    370                 375                 380                 


His Val Gln Arg Ala Arg Asn Gly Gly Leu Arg Pro Leu Glu Val Arg 
385                 390                 395                 400 


Arg Ala Pro Val Pro Asp Gly Ala Pro Ser Arg Tyr Pro Pro Val Ala 
                405                 410                 415     


Thr Cys His Arg Pro Gly Ser Thr Ser Phe Cys Pro Gly Glu Ser Ser 
            420                 425                 430         


Arg Met Gly Ile Lys Asp Arg Ile Arg Met Gly Ser Ser Gln Arg Arg 
        435                 440                 445             


Thr Gly Pro Ser Lys Gln His Leu Ala Pro Pro Thr Met Pro Thr Ser 
    450                 455                 460                 


Pro Ser Ser Glu Gln Val Gly Glu Ala Thr Ser Pro Thr Lys Val Gln 
465                 470                 475                 480 


Lys Ser Trp Ser Phe Asn Asp Arg Thr Arg Phe Arg Ala Ser Leu Arg 
                485                 490                 495     


Leu Lys Pro Arg Thr Ser Ala Glu Asp Ala Pro Ser Glu Glu Val Ala 
            500                 505                 510         


Glu Glu Lys Ser Tyr Gln Cys Glu Leu Thr Val Asp Asp Ile Met Pro 
        515                 520                 525             


Ala Val Lys Thr Val Ile Arg Ser Ile Arg Ile Leu Lys Phe Leu Val 
    530                 535                 540                 


Ala Lys Arg Lys Phe Lys Glu Thr Leu Arg Pro Tyr Asp Val Lys Asp 
545                 550                 555                 560 


Val Ile Glu Gln Tyr Ser Ala Gly His Leu Asp Met Leu Gly Arg Ile 
                565                 570                 575     


Lys Ser Leu Gln Thr Arg Val Asp Gln Ile Val Gly Arg Gly Pro Gly 
            580                 585                 590         


Asp Arg Lys Ala Arg Glu Lys Gly Asp Lys Gly Pro Ser Asp Ala Glu 
        595                 600                 605             


Val Val Asp Glu Ile Ser Met Met Gly Arg Val Val Lys Val Glu Lys 
    610                 615                 620                 


Gln Val Gln Ser Ile Glu His Lys Leu Asp Leu Leu Leu Gly Phe Tyr 
625                 630                 635                 640 


Ser Arg Cys Leu Arg Ser Gly Thr Ser Ala Ser Leu Gly Ala Val Gln 
                645                 650                 655     


Val Pro Leu Phe Asp Pro Asp Ile Thr Ser Asp Tyr His Ser Pro Val 
            660                 665                 670         


Asp His Glu Asp Ile Ser Val Ser Ala Gln Thr Leu Ser Ile Ser Arg 
        675                 680                 685             


Ser Val Ser Thr Asn Met Asp 
    690                 695 


<210> 47
<211> 932
<212> PRT
<213> Homo sapiens

<400> 47
Met Pro Arg His His Ala Gly Gly Glu Glu Gly Gly Ala Ala Gly Leu 
1               5                   10                  15      


Trp Val Lys Ser Gly Ala Ala Ala Ala Ala Ala Gly Gly Gly Arg Leu 
            20                  25                  30          


Gly Ser Gly Met Lys Asp Val Glu Ser Gly Arg Gly Arg Val Leu Leu 
        35                  40                  45              


Asn Ser Ala Ala Ala Arg Gly Asp Gly Leu Leu Leu Leu Gly Thr Arg 
    50                  55                  60                  


Ala Ala Thr Leu Gly Gly Gly Gly Gly Gly Leu Arg Glu Ser Arg Arg 
65                  70                  75                  80  


Gly Lys Gln Gly Ala Arg Met Ser Leu Leu Gly Lys Pro Leu Ser Tyr 
                85                  90                  95      


Thr Ser Ser Gln Ser Cys Arg Arg Asn Val Lys Tyr Arg Arg Val Gln 
            100                 105                 110         


Asn Tyr Leu Tyr Asn Val Leu Glu Arg Pro Arg Gly Trp Ala Phe Ile 
        115                 120                 125             


Tyr His Ala Phe Val Phe Leu Leu Val Phe Gly Cys Leu Ile Leu Ser 
    130                 135                 140                 


Val Phe Ser Thr Ile Pro Glu His Thr Lys Leu Ala Ser Ser Cys Leu 
145                 150                 155                 160 


Leu Ile Leu Glu Phe Val Met Ile Val Val Phe Gly Leu Glu Phe Ile 
                165                 170                 175     


Ile Arg Ile Trp Ser Ala Gly Cys Cys Cys Arg Tyr Arg Gly Trp Gln 
            180                 185                 190         


Gly Arg Leu Arg Phe Ala Arg Lys Pro Phe Cys Val Ile Asp Thr Ile 
        195                 200                 205             


Val Leu Ile Ala Ser Ile Ala Val Val Ser Ala Lys Thr Gln Gly Asn 
    210                 215                 220                 


Ile Phe Ala Thr Ser Ala Leu Arg Ser Leu Arg Phe Leu Gln Ile Leu 
225                 230                 235                 240 


Arg Met Val Arg Met Asp Arg Arg Gly Gly Thr Trp Lys Leu Leu Gly 
                245                 250                 255     


Ser Val Val Tyr Ala His Ser Lys Glu Leu Ile Thr Ala Trp Tyr Ile 
            260                 265                 270         


Gly Phe Leu Val Leu Ile Phe Ser Ser Phe Leu Val Tyr Leu Val Glu 
        275                 280                 285             


Lys Asp Ala Asn Lys Glu Phe Ser Thr Tyr Ala Asp Ala Leu Trp Trp 
    290                 295                 300                 


Gly Thr Ile Thr Leu Thr Thr Ile Gly Tyr Gly Asp Lys Thr Pro Leu 
305                 310                 315                 320 


Thr Trp Leu Gly Arg Leu Leu Ser Ala Gly Phe Ala Leu Leu Gly Ile 
                325                 330                 335     


Ser Phe Phe Ala Leu Pro Ala Gly Ile Leu Gly Ser Gly Phe Ala Leu 
            340                 345                 350         


Lys Val Gln Glu Gln His Arg Gln Lys His Phe Glu Lys Arg Arg Asn 
        355                 360                 365             


Pro Ala Ala Asn Leu Ile Gln Cys Val Trp Arg Ser Tyr Ala Ala Asp 
    370                 375                 380                 


Glu Lys Ser Val Ser Ile Ala Thr Trp Lys Pro His Leu Lys Ala Leu 
385                 390                 395                 400 


His Thr Cys Ser Pro Thr Lys Lys Glu Gln Gly Glu Ala Ser Ser Ser 
                405                 410                 415     


Gln Lys Leu Ser Phe Lys Glu Arg Val Arg Met Ala Ser Pro Arg Gly 
            420                 425                 430         


Gln Ser Ile Lys Ser Arg Gln Ala Ser Val Gly Asp Arg Arg Ser Pro 
        435                 440                 445             


Ser Thr Asp Ile Thr Ala Glu Gly Ser Pro Thr Lys Val Gln Lys Ser 
    450                 455                 460                 


Trp Ser Phe Asn Asp Arg Thr Arg Phe Arg Pro Ser Leu Arg Leu Lys 
465                 470                 475                 480 


Ser Ser Gln Pro Lys Pro Val Ile Asp Ala Asp Thr Ala Leu Gly Thr 
                485                 490                 495     


Asp Asp Val Tyr Asp Glu Lys Gly Cys Gln Cys Asp Val Ser Val Glu 
            500                 505                 510         


Asp Leu Thr Pro Pro Leu Lys Thr Val Ile Arg Ala Ile Arg Ile Met 
        515                 520                 525             


Lys Phe His Val Ala Lys Arg Lys Phe Lys Glu Thr Leu Arg Pro Tyr 
    530                 535                 540                 


Asp Val Lys Asp Val Ile Glu Gln Tyr Ser Ala Gly His Leu Asp Met 
545                 550                 555                 560 


Leu Cys Arg Ile Lys Ser Leu Gln Thr Arg Val Asp Gln Ile Leu Gly 
                565                 570                 575     


Lys Gly Gln Ile Thr Ser Asp Lys Lys Ser Arg Glu Lys Ile Thr Ala 
            580                 585                 590         


Glu His Glu Thr Thr Asp Asp Leu Ser Met Leu Gly Arg Val Val Lys 
        595                 600                 605             


Val Glu Lys Gln Val Gln Ser Ile Glu Ser Lys Leu Asp Cys Leu Leu 
    610                 615                 620                 


Asp Ile Tyr Gln Gln Val Leu Arg Lys Gly Ser Ala Ser Ala Leu Ala 
625                 630                 635                 640 


Leu Ala Ser Phe Gln Ile Pro Pro Phe Glu Cys Glu Gln Thr Ser Asp 
                645                 650                 655     


Tyr Gln Ser Pro Val Asp Ser Lys Asp Leu Ser Gly Ser Ala Gln Asn 
            660                 665                 670         


Ser Gly Cys Leu Ser Arg Ser Thr Ser Ala Asn Ile Ser Arg Gly Leu 
        675                 680                 685             


Gln Phe Ile Leu Thr Pro Asn Glu Phe Ser Ala Gln Thr Phe Tyr Ala 
    690                 695                 700                 


Leu Ser Pro Thr Met His Ser Gln Ala Thr Gln Val Pro Ile Ser Gln 
705                 710                 715                 720 


Ser Asp Gly Ser Ala Val Ala Ala Thr Asn Thr Ile Ala Asn Gln Ile 
                725                 730                 735     


Asn Thr Ala Pro Lys Pro Ala Ala Pro Thr Thr Leu Gln Ile Pro Pro 
            740                 745                 750         


Pro Leu Pro Ala Ile Lys His Leu Pro Arg Pro Glu Thr Leu His Pro 
        755                 760                 765             


Asn Pro Ala Gly Leu Gln Glu Ser Ile Ser Asp Val Thr Thr Cys Leu 
    770                 775                 780                 


Val Ala Ser Lys Glu Asn Val Gln Val Ala Gln Ser Asn Leu Thr Lys 
785                 790                 795                 800 


Asp Arg Ser Met Arg Lys Ser Phe Asp Met Gly Gly Glu Thr Leu Leu 
                805                 810                 815     


Ser Val Cys Pro Met Val Pro Lys Asp Leu Gly Lys Ser Leu Ser Val 
            820                 825                 830         


Gln Asn Leu Ile Arg Ser Thr Glu Glu Leu Asn Ile Gln Leu Ser Gly 
        835                 840                 845             


Ser Glu Ser Ser Gly Ser Arg Gly Ser Gln Asp Phe Tyr Pro Lys Trp 
    850                 855                 860                 


Arg Glu Ser Lys Leu Phe Ile Thr Asp Glu Glu Val Gly Pro Glu Glu 
865                 870                 875                 880 


Thr Glu Thr Asp Thr Phe Asp Ala Ala Pro Gln Pro Ala Arg Glu Ala 
                885                 890                 895     


Ala Phe Ala Ser Asp Ser Leu Arg Thr Gly Arg Ser Arg Ser Ser Gln 
            900                 905                 910         


Ser Ile Cys Lys Ala Gly Glu Ser Thr Asp Ala Leu Ser Leu Pro His 
        915                 920                 925             


Val Lys Leu Lys 
    930         


<210> 48
<211> 500
<212> PRT
<213> Homo sapiens

<400> 48
Met Pro Ser Ser Gly Arg Ala Leu Leu Asp Ser Pro Leu Asp Ser Gly 
1               5                   10                  15      


Ser Leu Thr Ser Leu Asp Ser Ser Val Phe Cys Ser Glu Gly Glu Gly 
            20                  25                  30          


Glu Pro Leu Ala Leu Gly Asp Cys Phe Thr Val Asn Val Gly Gly Ser 
        35                  40                  45              


Arg Phe Val Leu Ser Gln Gln Ala Leu Ser Cys Phe Pro His Thr Arg 
    50                  55                  60                  


Leu Gly Lys Leu Ala Val Val Val Ala Ser Tyr Arg Arg Pro Gly Ala 
65                  70                  75                  80  


Leu Ala Ala Val Pro Ser Pro Leu Glu Leu Cys Asp Asp Ala Asn Pro 
                85                  90                  95      


Val Asp Asn Glu Tyr Phe Phe Asp Arg Ser Ser Gln Ala Phe Arg Tyr 
            100                 105                 110         


Val Leu His Tyr Tyr Arg Thr Gly Arg Leu His Val Met Glu Gln Leu 
        115                 120                 125             


Cys Ala Leu Ser Phe Leu Gln Glu Ile Gln Tyr Trp Gly Ile Asp Glu 
    130                 135                 140                 


Leu Ser Ile Asp Ser Cys Cys Arg Asp Arg Tyr Phe Arg Arg Lys Glu 
145                 150                 155                 160 


Leu Ser Glu Thr Leu Asp Phe Lys Lys Asp Thr Glu Asp Gln Glu Ser 
                165                 170                 175     


Gln His Glu Ser Glu Gln Asp Phe Ser Gln Gly Pro Cys Pro Thr Val 
            180                 185                 190         


Arg Gln Lys Leu Trp Asn Ile Leu Glu Lys Pro Gly Ser Ser Thr Ala 
        195                 200                 205             


Ala Arg Ile Phe Gly Val Ile Ser Ile Ile Phe Val Val Val Ser Ile 
    210                 215                 220                 


Ile Asn Met Ala Leu Met Ser Ala Glu Leu Ser Trp Leu Asp Leu Gln 
225                 230                 235                 240 


Leu Leu Glu Ile Leu Glu Tyr Val Cys Ile Ser Trp Phe Thr Gly Glu 
                245                 250                 255     


Phe Val Leu Arg Phe Leu Cys Val Arg Asp Arg Cys Arg Phe Leu Arg 
            260                 265                 270         


Lys Val Pro Asn Ile Ile Asp Leu Leu Ala Ile Leu Pro Phe Tyr Ile 
        275                 280                 285             


Thr Leu Leu Val Glu Ser Leu Ser Gly Ser Gln Thr Thr Gln Glu Leu 
    290                 295                 300                 


Glu Asn Val Gly Arg Ile Val Gln Val Leu Arg Leu Leu Arg Ala Leu 
305                 310                 315                 320 


Arg Met Leu Lys Leu Gly Arg His Ser Thr Gly Leu Arg Ser Leu Gly 
                325                 330                 335     


Met Thr Ile Thr Gln Cys Tyr Glu Glu Val Gly Leu Leu Leu Leu Phe 
            340                 345                 350         


Leu Ser Val Gly Ile Ser Ile Phe Ser Thr Val Glu Tyr Phe Ala Glu 
        355                 360                 365             


Gln Ser Ile Pro Asp Thr Thr Phe Thr Ser Val Pro Cys Ala Trp Trp 
    370                 375                 380                 


Trp Ala Thr Thr Ser Met Thr Thr Val Gly Tyr Gly Asp Ile Arg Pro 
385                 390                 395                 400 


Asp Thr Thr Thr Gly Lys Ile Val Ala Phe Met Cys Ile Leu Ser Gly 
                405                 410                 415     


Ile Leu Val Leu Ala Leu Pro Ile Ala Ile Ile Asn Asp Arg Phe Ser 
            420                 425                 430         


Ala Cys Tyr Phe Thr Leu Lys Leu Lys Glu Ala Ala Val Arg Gln Arg 
        435                 440                 445             


Glu Ala Leu Lys Lys Leu Thr Lys Asn Ile Ala Thr Asp Ser Tyr Ile 
    450                 455                 460                 


Ser Val Asn Leu Arg Asp Val Tyr Ala Arg Ser Ile Met Glu Met Leu 
465                 470                 475                 480 


Arg Leu Lys Gly Arg Glu Arg Ala Ser Thr Arg Ser Ser Gly Gly Asp 
                485                 490                 495     


Asp Phe Trp Phe 
            500 


<210> 49
<211> 545
<212> PRT
<213> Homo sapiens

<400> 49
Met Leu Lys Gln Ser Glu Arg Arg Arg Ser Trp Ser Tyr Arg Pro Trp 
1               5                   10                  15      


Asn Thr Thr Glu Asn Glu Gly Ser Gln His Arg Arg Ser Ile Cys Ser 
            20                  25                  30          


Leu Gly Ala Arg Ser Gly Ser Gln Ala Ser Ile His Gly Trp Thr Glu 
        35                  40                  45              


Gly Asn Tyr Asn Tyr Tyr Ile Glu Glu Asp Glu Asp Gly Glu Glu Glu 
    50                  55                  60                  


Asp Gln Trp Lys Asp Asp Leu Ala Glu Glu Asp Gln Gln Ala Gly Glu 
65                  70                  75                  80  


Val Thr Thr Ala Lys Pro Glu Gly Pro Ser Asp Pro Pro Ala Leu Leu 
                85                  90                  95      


Ser Thr Leu Asn Val Asn Val Gly Gly His Ser Tyr Gln Leu Asp Tyr 
            100                 105                 110         


Cys Glu Leu Ala Gly Phe Pro Lys Thr Arg Leu Gly Arg Leu Ala Thr 
        115                 120                 125             


Ser Thr Ser Arg Ser Arg Gln Leu Ser Leu Cys Asp Asp Tyr Glu Glu 
    130                 135                 140                 


Gln Thr Asp Glu Tyr Phe Phe Asp Arg Asp Pro Ala Val Phe Gln Leu 
145                 150                 155                 160 


Val Tyr Asn Phe Tyr Leu Ser Gly Val Leu Leu Val Leu Asp Gly Leu 
                165                 170                 175     


Cys Pro Arg Arg Phe Leu Glu Glu Leu Gly Tyr Trp Gly Val Arg Leu 
            180                 185                 190         


Lys Tyr Thr Pro Arg Cys Cys Arg Ile Cys Phe Glu Glu Arg Arg Asp 
        195                 200                 205             


Glu Leu Ser Glu Arg Leu Lys Ile Gln His Glu Leu Arg Ala Gln Ala 
    210                 215                 220                 


Gln Val Glu Glu Ala Glu Glu Leu Phe Arg Asp Met Arg Phe Tyr Gly 
225                 230                 235                 240 


Pro Gln Arg Arg Arg Leu Trp Asn Leu Met Glu Lys Pro Phe Ser Ser 
                245                 250                 255     


Val Ala Ala Lys Ala Ile Gly Val Ala Ser Ser Thr Phe Val Leu Val 
            260                 265                 270         


Ser Val Val Ala Leu Ala Leu Asn Thr Val Glu Glu Met Gln Gln His 
        275                 280                 285             


Ser Gly Gln Gly Glu Gly Gly Pro Asp Leu Arg Pro Ile Leu Glu His 
    290                 295                 300                 


Val Glu Met Leu Cys Met Gly Phe Phe Thr Leu Glu Tyr Leu Leu Arg 
305                 310                 315                 320 


Leu Ala Ser Thr Pro Asp Leu Arg Arg Phe Ala Arg Ser Ala Leu Asn 
                325                 330                 335     


Leu Val Asp Leu Val Ala Ile Leu Pro Leu Tyr Leu Gln Leu Leu Leu 
            340                 345                 350         


Glu Cys Phe Thr Gly Glu Gly His Gln Arg Gly Gln Thr Val Gly Ser 
        355                 360                 365             


Val Gly Lys Val Gly Gln Val Leu Arg Val Met Arg Leu Met Arg Ile 
    370                 375                 380                 


Phe Arg Ile Leu Lys Leu Ala Arg His Ser Thr Gly Leu Arg Ala Phe 
385                 390                 395                 400 


Gly Phe Thr Leu Arg Gln Cys Tyr Gln Gln Val Gly Cys Leu Leu Leu 
                405                 410                 415     


Phe Ile Ala Met Gly Ile Phe Thr Phe Ser Ala Ala Val Tyr Ser Val 
            420                 425                 430         


Glu His Asp Val Pro Ser Thr Asn Phe Thr Thr Ile Pro His Ser Trp 
        435                 440                 445             


Trp Trp Ala Ala Val Ser Ile Ser Thr Val Gly Tyr Gly Asp Met Tyr 
    450                 455                 460                 


Pro Glu Thr His Leu Gly Arg Phe Phe Ala Phe Leu Cys Ile Ala Phe 
465                 470                 475                 480 


Gly Ile Ile Leu Asn Gly Met Pro Ile Ser Ile Leu Tyr Asn Lys Phe 
                485                 490                 495     


Ser Asp Tyr Tyr Ser Lys Leu Lys Ala Tyr Glu Tyr Thr Thr Ile Arg 
            500                 505                 510         


Arg Glu Arg Gly Glu Val Asn Phe Met Gln Arg Ala Arg Lys Lys Ile 
        515                 520                 525             


Ala Glu Cys Leu Leu Gly Ser Asn Pro Gln Leu Thr Pro Arg Gln Glu 
    530                 535                 540                 


Asn 
545 


<210> 50
<211> 526
<212> PRT
<213> Homo sapiens

<400> 50
Met Leu Met Leu Leu Val Arg Gly Thr His Tyr Glu Asn Leu Arg Ser 
1               5                   10                  15      


Lys Val Val Leu Pro Thr Pro Leu Gly Gly Arg Ser Thr Glu Thr Phe 
            20                  25                  30          


Val Ser Glu Phe Pro Gly Pro Asp Thr Gly Ile Arg Trp Arg Arg Ser 
        35                  40                  45              


Asp Glu Ala Leu Arg Val Asn Val Gly Gly Val Arg Arg Gln Leu Ser 
    50                  55                  60                  


Ala Arg Ala Leu Ala Arg Phe Pro Gly Thr Arg Leu Gly Arg Leu Gln 
65                  70                  75                  80  


Ala Ala Ala Ser Glu Glu Gln Ala Arg Arg Leu Cys Asp Asp Tyr Asp 
                85                  90                  95      


Glu Ala Ala Arg Glu Phe Tyr Phe Asp Arg His Pro Gly Phe Phe Leu 
            100                 105                 110         


Ser Leu Leu His Phe Tyr Arg Thr Gly His Leu His Val Leu Asp Glu 
        115                 120                 125             


Leu Cys Val Phe Ala Phe Gly Gln Glu Ala Asp Tyr Trp Gly Leu Gly 
    130                 135                 140                 


Glu Asn Ala Leu Ala Ala Cys Cys Arg Ala Arg Tyr Leu Glu Arg Arg 
145                 150                 155                 160 


Leu Thr Gln Pro His Ala Trp Asp Glu Asp Ser Asp Thr Pro Ser Ser 
                165                 170                 175     


Val Asp Pro Cys Pro Asp Glu Ile Ser Asp Val Gln Arg Glu Leu Ala 
            180                 185                 190         


Arg Tyr Gly Ala Ala Arg Cys Gly Arg Leu Arg Arg Arg Leu Trp Leu 
        195                 200                 205             


Thr Met Glu Asn Pro Gly Tyr Ser Leu Pro Ser Lys Leu Phe Ser Cys 
    210                 215                 220                 


Val Ser Ile Ser Val Val Leu Ala Ser Ile Ala Ala Met Cys Ile His 
225                 230                 235                 240 


Ser Leu Pro Glu Tyr Gln Ala Arg Glu Ala Ala Ala Ala Val Ala Ala 
                245                 250                 255     


Val Ala Ala Gly Arg Ser Pro Glu Gly Val Arg Asp Asp Pro Val Leu 
            260                 265                 270         


Arg Arg Leu Glu Tyr Phe Cys Ile Ala Trp Phe Ser Phe Glu Val Ser 
        275                 280                 285             


Ser Arg Leu Leu Leu Ala Pro Ser Thr Arg Asn Phe Phe Cys His Pro 
    290                 295                 300                 


Leu Asn Leu Ile Asp Ile Val Ser Val Leu Pro Phe Tyr Leu Thr Leu 
305                 310                 315                 320 


Leu Ala Gly Val Ala Leu Gly Asp Gln Gly Gly Lys Glu Phe Gly His 
                325                 330                 335     


Leu Gly Lys Val Val Gln Val Phe Arg Leu Met Arg Ile Phe Arg Val 
            340                 345                 350         


Leu Lys Leu Ala Arg His Ser Thr Gly Leu Arg Ser Leu Gly Ala Thr 
        355                 360                 365             


Leu Lys His Ser Tyr Arg Glu Val Gly Ile Leu Leu Leu Tyr Leu Ala 
    370                 375                 380                 


Val Gly Val Ser Val Phe Ser Gly Val Ala Tyr Thr Ala Glu Lys Glu 
385                 390                 395                 400 


Glu Asp Val Gly Phe Asn Thr Ile Pro Ala Cys Trp Trp Trp Gly Thr 
                405                 410                 415     


Val Ser Met Thr Thr Val Gly Tyr Gly Asp Val Val Pro Val Thr Val 
            420                 425                 430         


Ala Gly Lys Leu Ala Ala Ser Gly Cys Ile Leu Gly Gly Ile Leu Val 
        435                 440                 445             


Val Ala Leu Pro Ile Thr Ile Ile Phe Asn Lys Phe Ser His Phe Tyr 
    450                 455                 460                 


Arg Arg Gln Lys Ala Leu Glu Ala Ala Val Arg Asn Ser Asn His Gln 
465                 470                 475                 480 


Glu Phe Glu Asp Leu Leu Ser Ser Ile Asp Gly Val Ser Glu Ala Ser 
                485                 490                 495     


Leu Glu Thr Ser Arg Glu Thr Ser Gln Glu Gly Gln Ser Ala Asp Leu 
            500                 505                 510         


Glu Ser Gln Ala Pro Ser Glu Pro Pro His Pro Gln Met Tyr 
        515                 520                 525     


<210> 51
<211> 477
<212> PRT
<213> Homo sapiens

<400> 51
Met Thr Gly Gln Ser Leu Trp Asp Val Ser Glu Ala Asn Val Glu Asp 
1               5                   10                  15      


Gly Glu Ile Arg Ile Asn Val Gly Gly Phe Lys Arg Arg Leu Arg Ser 
            20                  25                  30          


His Thr Leu Leu Arg Phe Pro Glu Thr Arg Leu Gly Arg Leu Leu Leu 
        35                  40                  45              


Cys His Ser Arg Glu Ala Ile Leu Glu Leu Cys Asp Asp Tyr Asp Asp 
    50                  55                  60                  


Val Gln Arg Glu Phe Tyr Phe Asp Arg Asn Pro Glu Leu Phe Pro Tyr 
65                  70                  75                  80  


Val Leu His Phe Tyr His Thr Gly Lys Leu His Val Met Ala Glu Leu 
                85                  90                  95      


Cys Val Phe Ser Phe Ser Gln Glu Ile Glu Tyr Trp Gly Ile Asn Glu 
            100                 105                 110         


Phe Phe Ile Asp Ser Cys Cys Ser Tyr Ser Tyr His Gly Arg Lys Val 
        115                 120                 125             


Glu Pro Glu Gln Glu Lys Trp Asp Glu Gln Ser Asp Gln Glu Ser Thr 
    130                 135                 140                 


Thr Ser Ser Phe Asp Glu Ile Leu Ala Phe Tyr Asn Asp Ala Ser Lys 
145                 150                 155                 160 


Phe Asp Gly Gln Pro Leu Gly Asn Phe Arg Arg Gln Leu Trp Leu Ala 
                165                 170                 175     


Leu Asp Asn Pro Gly Tyr Ser Val Leu Ser Arg Val Phe Ser Ile Leu 
            180                 185                 190         


Ser Ile Leu Val Val Met Gly Ser Ile Ile Thr Met Cys Leu Asn Ser 
        195                 200                 205             


Leu Pro Asp Phe Gln Ile Pro Asp Ser Gln Gly Asn Pro Gly Glu Asp 
    210                 215                 220                 


Pro Arg Phe Glu Ile Val Glu His Phe Gly Ile Ala Trp Phe Thr Phe 
225                 230                 235                 240 


Glu Leu Val Ala Arg Phe Ala Val Ala Pro Asp Phe Leu Lys Phe Phe 
                245                 250                 255     


Lys Asn Ala Leu Asn Leu Ile Asp Leu Met Ser Ile Val Pro Phe Tyr 
            260                 265                 270         


Ile Thr Leu Val Val Asn Leu Val Val Glu Ser Thr Pro Thr Leu Ala 
        275                 280                 285             


Asn Leu Gly Arg Val Ala Gln Val Leu Arg Leu Met Arg Ile Phe Arg 
    290                 295                 300                 


Ile Leu Lys Leu Ala Arg His Ser Thr Gly Leu Arg Ser Leu Gly Ala 
305                 310                 315                 320 


Thr Leu Lys Tyr Ser Tyr Lys Glu Val Gly Leu Leu Leu Leu Tyr Leu 
                325                 330                 335     


Ser Val Gly Ile Ser Ile Phe Ser Val Val Ala Tyr Thr Ile Glu Lys 
            340                 345                 350         


Glu Glu Asn Glu Gly Leu Ala Thr Ile Pro Ala Cys Trp Trp Trp Ala 
        355                 360                 365             


Thr Val Ser Met Thr Thr Val Gly Tyr Gly Asp Val Val Pro Gly Thr 
    370                 375                 380                 


Thr Ala Gly Lys Leu Thr Ala Ser Ala Cys Ile Leu Ala Gly Ile Leu 
385                 390                 395                 400 


Val Val Val Leu Pro Ile Thr Leu Ile Phe Asn Lys Phe Ser His Phe 
                405                 410                 415     


Tyr Arg Arg Gln Lys Gln Leu Glu Ser Ala Met Arg Ser Cys Asp Phe 
            420                 425                 430         


Gly Asp Gly Met Lys Glu Val Pro Ser Val Asn Leu Arg Asp Tyr Tyr 
        435                 440                 445             


Ala His Lys Val Lys Ser Leu Met Ala Ser Leu Thr Asn Met Ser Arg 
    450                 455                 460                 


Ser Ser Pro Ser Glu Leu Ser Leu Asn Asp Ser Leu Arg 
465                 470                 475         


<210> 52
<211> 477
<212> PRT
<213> Homo sapiens

<400> 52
Met Thr Arg Gln Ser Leu Trp Asp Leu Ser Glu Thr Asp Val Glu Asp 
1               5                   10                  15      


Gly Glu Ile Arg Ile Asn Val Gly Gly Phe Lys Arg Arg Leu Arg Ser 
            20                  25                  30          


His Thr Leu Leu Arg Phe Pro Glu Thr Arg Leu Gly Arg Leu Leu Leu 
        35                  40                  45              


Cys His Ser Arg Glu Ala Ile Leu Glu Leu Cys Asp Asp Tyr Asp Asp 
    50                  55                  60                  


Val Gln Arg Glu Phe Tyr Phe Asp Arg Asn Pro Glu Leu Phe Pro Tyr 
65                  70                  75                  80  


Val Leu His Phe Tyr His Thr Gly Lys Leu His Val Met Ala Glu Leu 
                85                  90                  95      


Cys Val Phe Ser Phe Ser Gln Glu Ile Glu Tyr Trp Gly Ile Asn Glu 
            100                 105                 110         


Phe Phe Ile Asp Ser Cys Cys Ser Tyr Ser Tyr His Gly Arg Lys Val 
        115                 120                 125             


Glu Pro Glu Gln Glu Lys Trp Asp Glu Gln Ser Asp Gln Glu Ser Thr 
    130                 135                 140                 


Thr Ser Ser Phe Asp Glu Ile Leu Ala Phe Tyr Asn Asp Ala Ser Lys 
145                 150                 155                 160 


Phe Asp Gly Gln Pro Leu Gly Asn Phe Arg Arg Gln Leu Trp Leu Ala 
                165                 170                 175     


Leu Asp Asn Pro Gly Tyr Ser Val Leu Ser Arg Val Phe Ser Val Leu 
            180                 185                 190         


Ser Ile Leu Val Val Leu Gly Ser Ile Ile Thr Met Cys Leu Asn Ser 
        195                 200                 205             


Leu Pro Asp Phe Gln Ile Pro Asp Ser Gln Gly Asn Pro Gly Glu Asp 
    210                 215                 220                 


Pro Arg Phe Glu Ile Val Glu His Phe Gly Ile Ala Trp Phe Thr Phe 
225                 230                 235                 240 


Glu Leu Val Ala Arg Phe Ala Val Ala Pro Asp Phe Leu Lys Phe Phe 
                245                 250                 255     


Lys Asn Ala Leu Asn Leu Ile Asp Leu Met Ser Ile Val Pro Phe Tyr 
            260                 265                 270         


Ile Thr Leu Val Val Asn Leu Val Val Glu Ser Ser Pro Thr Leu Ala 
        275                 280                 285             


Asn Leu Gly Arg Val Ala Gln Val Leu Arg Leu Met Arg Ile Phe Arg 
    290                 295                 300                 


Ile Leu Lys Leu Ala Arg His Ser Thr Gly Leu Arg Ser Leu Gly Ala 
305                 310                 315                 320 


Thr Leu Lys Tyr Ser Tyr Lys Glu Val Gly Leu Leu Leu Leu Tyr Leu 
                325                 330                 335     


Ser Val Gly Ile Ser Ile Phe Ser Val Val Ala Tyr Thr Ile Glu Lys 
            340                 345                 350         


Glu Glu Asn Glu Gly Leu Ala Thr Ile Pro Ala Cys Trp Trp Trp Ala 
        355                 360                 365             


Thr Val Ser Met Thr Thr Val Gly Tyr Gly Asp Val Val Pro Gly Thr 
    370                 375                 380                 


Thr Ala Gly Lys Leu Thr Ala Ser Ala Cys Ile Leu Ala Gly Ile Leu 
385                 390                 395                 400 


Val Val Val Leu Pro Ile Thr Leu Ile Phe Asn Lys Phe Ser His Phe 
                405                 410                 415     


Tyr Arg Arg Gln Lys Gln Leu Glu Ser Ala Met Arg Ser Cys Asp Phe 
            420                 425                 430         


Gly Asp Gly Met Lys Glu Val Pro Ser Val Asn Leu Arg Asp Tyr Tyr 
        435                 440                 445             


Ala His Lys Val Lys Ser Leu Met Ala Ser Leu Thr Asn Met Ser Arg 
    450                 455                 460                 


Ser Ser Pro Ser Glu Leu Ser Leu Asp Asp Ser Leu His 
465                 470                 475         


<210> 53
<211> 989
<212> PRT
<213> Homo sapiens

<400> 53
Met Thr Met Ala Gly Gly Arg Arg Gly Leu Val Ala Pro Gln Asn Thr 
1               5                   10                  15      


Phe Leu Glu Asn Ile Val Arg Arg Ser Asn Asp Thr Asn Phe Val Leu 
            20                  25                  30          


Gly Asn Ala Gln Ile Val Asp Trp Pro Ile Val Tyr Ser Asn Asp Gly 
        35                  40                  45              


Phe Cys Lys Leu Ser Gly Tyr His Arg Ala Glu Val Met Gln Lys Ser 
    50                  55                  60                  


Ser Thr Cys Ser Phe Met Tyr Gly Glu Leu Thr Asp Lys Asp Thr Ile 
65                  70                  75                  80  


Glu Lys Val Arg Gln Thr Phe Glu Asn Tyr Glu Met Asn Ser Phe Glu 
                85                  90                  95      


Ile Leu Met Tyr Lys Lys Asn Arg Thr Pro Val Trp Phe Phe Val Lys 
            100                 105                 110         


Ile Ala Pro Ile Arg Asn Glu Gln Asp Lys Val Val Leu Phe Leu Cys 
        115                 120                 125             


Thr Phe Ser Asp Ile Thr Ala Phe Lys Gln Pro Ile Glu Asp Asp Ser 
    130                 135                 140                 


Cys Lys Gly Trp Gly Lys Phe Ala Arg Leu Thr Arg Ala Leu Thr Ser 
145                 150                 155                 160 


Ser Arg Gly Val Leu Gln Gln Leu Ala Pro Ser Val Gln Lys Gly Glu 
                165                 170                 175     


Asn Val His Lys His Ser Arg Leu Ala Glu Val Leu Gln Leu Gly Ser 
            180                 185                 190         


Asp Ile Leu Pro Gln Tyr Lys Gln Glu Ala Pro Lys Thr Pro Pro His 
        195                 200                 205             


Ile Ile Leu His Tyr Cys Val Phe Lys Thr Thr Trp Asp Trp Ile Ile 
    210                 215                 220                 


Leu Ile Leu Thr Phe Tyr Thr Ala Ile Leu Val Pro Tyr Asn Val Ser 
225                 230                 235                 240 


Phe Lys Thr Arg Gln Asn Asn Val Ala Trp Leu Val Val Asp Ser Ile 
                245                 250                 255     


Val Asp Val Ile Phe Leu Val Asp Ile Val Leu Asn Phe His Thr Thr 
            260                 265                 270         


Phe Val Gly Pro Ala Gly Glu Val Ile Ser Asp Pro Lys Leu Ile Arg 
        275                 280                 285             


Met Asn Tyr Leu Lys Thr Trp Phe Val Ile Asp Leu Leu Ser Cys Leu 
    290                 295                 300                 


Pro Tyr Asp Val Ile Asn Ala Phe Glu Asn Val Asp Glu Val Ser Ala 
305                 310                 315                 320 


Phe Met Gly Asp Pro Gly Lys Ile Gly Phe Ala Asp Gln Ile Pro Pro 
                325                 330                 335     


Pro Leu Glu Gly Arg Glu Ser Gln Gly Ile Ser Ser Leu Phe Ser Ser 
            340                 345                 350         


Leu Lys Val Val Arg Leu Leu Arg Leu Gly Arg Val Ala Arg Lys Leu 
        355                 360                 365             


Asp His Tyr Ile Glu Tyr Gly Ala Ala Val Leu Val Leu Leu Val Cys 
    370                 375                 380                 


Val Phe Gly Leu Ala Ala His Trp Met Ala Cys Ile Trp Tyr Ser Ile 
385                 390                 395                 400 


Gly Asp Tyr Glu Ile Phe Asp Glu Asp Thr Lys Thr Ile Arg Asn Asn 
                405                 410                 415     


Ser Trp Leu Tyr Gln Leu Ala Met Asp Ile Gly Thr Pro Tyr Gln Phe 
            420                 425                 430         


Asn Gly Ser Gly Ser Gly Lys Trp Glu Gly Gly Pro Ser Lys Asn Ser 
        435                 440                 445             


Val Tyr Ile Ser Ser Leu Tyr Phe Thr Met Thr Ser Leu Thr Ser Val 
    450                 455                 460                 


Gly Phe Gly Asn Ile Ala Pro Ser Thr Asp Ile Glu Lys Ile Phe Ala 
465                 470                 475                 480 


Val Ala Ile Met Met Ile Gly Ser Leu Leu Tyr Ala Thr Ile Phe Gly 
                485                 490                 495     


Asn Val Thr Thr Ile Phe Gln Gln Met Tyr Ala Asn Thr Asn Arg Tyr 
            500                 505                 510         


His Glu Met Leu Asn Ser Val Arg Asp Phe Leu Lys Leu Tyr Gln Val 
        515                 520                 525             


Pro Lys Gly Leu Ser Glu Arg Val Met Asp Tyr Ile Val Ser Thr Trp 
    530                 535                 540                 


Ser Met Ser Arg Gly Ile Asp Thr Glu Lys Val Leu Gln Ile Cys Pro 
545                 550                 555                 560 


Lys Asp Met Arg Ala Asp Ile Cys Val His Leu Asn Arg Lys Val Phe 
                565                 570                 575     


Lys Glu His Pro Ala Phe Arg Leu Ala Ser Asp Gly Cys Leu Arg Ala 
            580                 585                 590         


Leu Ala Met Glu Phe Gln Thr Val His Cys Ala Pro Gly Asp Leu Ile 
        595                 600                 605             


Tyr His Ala Gly Glu Ser Val Asp Ser Leu Cys Phe Val Val Ser Gly 
    610                 615                 620                 


Ser Leu Glu Val Ile Gln Asp Asp Glu Val Val Ala Ile Leu Gly Lys 
625                 630                 635                 640 


Gly Asp Val Phe Gly Asp Val Phe Trp Lys Glu Ala Thr Leu Ala Gln 
                645                 650                 655     


Ser Cys Ala Asn Val Arg Ala Leu Thr Tyr Cys Asp Leu His Val Ile 
            660                 665                 670         


Lys Arg Asp Ala Leu Gln Lys Val Leu Glu Phe Tyr Thr Ala Phe Ser 
        675                 680                 685             


His Ser Phe Ser Arg Asn Leu Ile Leu Thr Tyr Asn Leu Arg Lys Arg 
    690                 695                 700                 


Ile Val Phe Arg Lys Ile Ser Asp Val Lys Arg Glu Glu Glu Glu Arg 
705                 710                 715                 720 


Met Lys Arg Lys Asn Glu Ala Pro Leu Ile Leu Pro Pro Asp His Pro 
                725                 730                 735     


Val Arg Arg Leu Phe Gln Arg Phe Arg Gln Gln Lys Glu Ala Arg Leu 
            740                 745                 750         


Ala Ala Glu Arg Gly Gly Arg Asp Leu Asp Asp Leu Asp Val Glu Lys 
        755                 760                 765             


Gly Asn Val Leu Thr Glu His Ala Ser Ala Asn His Ser Leu Val Lys 
    770                 775                 780                 


Ala Ser Val Val Thr Val Arg Glu Ser Pro Ala Thr Pro Val Ser Phe 
785                 790                 795                 800 


Gln Ala Ala Ser Thr Ser Gly Val Pro Asp His Ala Lys Leu Gln Ala 
                805                 810                 815     


Pro Gly Ser Glu Cys Leu Gly Pro Lys Gly Gly Gly Gly Asp Cys Ala 
            820                 825                 830         


Lys Arg Lys Ser Trp Ala Arg Phe Lys Asp Ala Cys Gly Lys Ser Glu 
        835                 840                 845             


Asp Trp Asn Lys Val Ser Lys Ala Glu Ser Met Glu Thr Leu Pro Glu 
    850                 855                 860                 


Arg Thr Lys Ala Ser Gly Glu Ala Thr Leu Lys Lys Thr Asp Ser Cys 
865                 870                 875                 880 


Asp Ser Gly Ile Thr Lys Ser Asp Leu Arg Leu Asp Asn Val Gly Glu 
                885                 890                 895     


Ala Arg Ser Pro Gln Asp Arg Ser Pro Ile Leu Ala Glu Val Lys His 
            900                 905                 910         


Ser Phe Tyr Pro Ile Pro Glu Gln Thr Leu Gln Ala Thr Val Leu Glu 
        915                 920                 925             


Val Arg His Glu Leu Lys Glu Asp Ile Lys Ala Leu Asn Ala Lys Met 
    930                 935                 940                 


Thr Asn Ile Glu Lys Gln Leu Ser Glu Ile Leu Arg Ile Leu Thr Ser 
945                 950                 955                 960 


Arg Arg Ser Ser Gln Ser Pro Gln Glu Leu Phe Glu Ile Ser Arg Pro 
                965                 970                 975     


Gln Ser Pro Glu Ser Glu Arg Asp Ile Phe Gly Ala Ser 
            980                 985                 


<210> 54
<211> 988
<212> PRT
<213> Homo sapiens

<400> 54
Met Pro Gly Gly Lys Arg Gly Leu Val Ala Pro Gln Asn Thr Phe Leu 
1               5                   10                  15      


Glu Asn Ile Val Arg Arg Ser Ser Glu Ser Ser Phe Leu Leu Gly Asn 
            20                  25                  30          


Ala Gln Ile Val Asp Trp Pro Val Val Tyr Ser Asn Asp Gly Phe Cys 
        35                  40                  45              


Lys Leu Ser Gly Tyr His Arg Ala Asp Val Met Gln Lys Ser Ser Thr 
    50                  55                  60                  


Cys Ser Phe Met Tyr Gly Glu Leu Thr Asp Lys Lys Thr Ile Glu Lys 
65                  70                  75                  80  


Val Arg Gln Thr Phe Asp Asn Tyr Glu Ser Asn Cys Phe Glu Val Leu 
                85                  90                  95      


Leu Tyr Lys Lys Asn Arg Thr Pro Val Trp Phe Tyr Met Gln Ile Ala 
            100                 105                 110         


Pro Ile Arg Asn Glu His Glu Lys Val Val Leu Phe Leu Cys Thr Phe 
        115                 120                 125             


Lys Asp Ile Thr Leu Phe Lys Gln Pro Ile Glu Asp Asp Ser Thr Lys 
    130                 135                 140                 


Gly Trp Thr Lys Phe Ala Arg Leu Thr Arg Ala Leu Thr Asn Ser Arg 
145                 150                 155                 160 


Ser Val Leu Gln Gln Leu Thr Pro Met Asn Lys Thr Glu Val Val His 
                165                 170                 175     


Lys His Ser Arg Leu Ala Glu Val Leu Gln Leu Gly Ser Asp Ile Leu 
            180                 185                 190         


Pro Gln Tyr Lys Gln Glu Ala Pro Lys Thr Pro Pro His Ile Ile Leu 
        195                 200                 205             


His Tyr Cys Ala Phe Lys Thr Thr Trp Asp Trp Val Ile Leu Ile Leu 
    210                 215                 220                 


Thr Phe Tyr Thr Ala Ile Met Val Pro Tyr Asn Val Ser Phe Lys Thr 
225                 230                 235                 240 


Lys Gln Asn Asn Ile Ala Trp Leu Val Leu Asp Ser Val Val Asp Val 
                245                 250                 255     


Ile Phe Leu Val Asp Ile Val Leu Asn Phe His Thr Thr Phe Val Gly 
            260                 265                 270         


Pro Gly Gly Glu Val Ile Ser Asp Pro Lys Leu Ile Arg Met Asn Tyr 
        275                 280                 285             


Leu Lys Thr Trp Phe Val Ile Asp Leu Leu Ser Cys Leu Pro Tyr Asp 
    290                 295                 300                 


Ile Ile Asn Ala Phe Glu Asn Val Asp Glu Gly Ile Ser Ser Leu Phe 
305                 310                 315                 320 


Ser Ser Leu Lys Val Val Arg Leu Leu Arg Leu Gly Arg Val Ala Arg 
                325                 330                 335     


Lys Leu Asp His Tyr Leu Glu Tyr Gly Ala Ala Val Leu Val Leu Leu 
            340                 345                 350         


Val Cys Val Phe Gly Leu Val Ala His Trp Leu Ala Cys Ile Trp Tyr 
        355                 360                 365             


Ser Ile Gly Asp Tyr Glu Val Ile Asp Glu Val Thr Asn Thr Ile Gln 
    370                 375                 380                 


Ile Asp Ser Trp Leu Tyr Gln Leu Ala Leu Ser Ile Gly Thr Pro Tyr 
385                 390                 395                 400 


Arg Tyr Asn Thr Ser Ala Gly Ile Trp Glu Gly Gly Pro Ser Lys Asp 
                405                 410                 415     


Ser Leu Tyr Val Ser Ser Leu Tyr Phe Thr Met Thr Ser Leu Thr Thr 
            420                 425                 430         


Ile Gly Phe Gly Asn Ile Ala Pro Thr Thr Asp Val Glu Lys Met Phe 
        435                 440                 445             


Ser Val Ala Met Met Met Val Gly Ser Leu Leu Tyr Ala Thr Ile Phe 
    450                 455                 460                 


Gly Asn Val Thr Thr Ile Phe Gln Gln Met Tyr Ala Asn Thr Asn Arg 
465                 470                 475                 480 


Tyr His Glu Met Leu Asn Asn Val Arg Asp Phe Leu Lys Leu Tyr Gln 
                485                 490                 495     


Val Pro Lys Gly Leu Ser Glu Arg Val Met Asp Tyr Ile Val Ser Thr 
            500                 505                 510         


Trp Ser Met Ser Lys Gly Ile Asp Thr Glu Lys Val Leu Ser Ile Cys 
        515                 520                 525             


Pro Lys Asp Met Arg Ala Asp Ile Cys Val His Leu Asn Arg Lys Val 
    530                 535                 540                 


Phe Asn Glu His Pro Ala Phe Arg Leu Ala Ser Asp Gly Cys Leu Arg 
545                 550                 555                 560 


Ala Leu Ala Val Glu Phe Gln Thr Ile His Cys Ala Pro Gly Asp Leu 
                565                 570                 575     


Ile Tyr His Ala Gly Glu Ser Val Asp Ala Leu Cys Phe Val Val Ser 
            580                 585                 590         


Gly Ser Leu Glu Val Ile Gln Asp Asp Glu Val Val Ala Ile Leu Gly 
        595                 600                 605             


Lys Gly Asp Val Phe Gly Asp Ile Phe Trp Lys Glu Thr Thr Leu Ala 
    610                 615                 620                 


His Ala Cys Ala Asn Val Arg Ala Leu Thr Tyr Cys Asp Leu His Ile 
625                 630                 635                 640 


Ile Lys Arg Glu Ala Leu Leu Lys Val Leu Asp Phe Tyr Thr Ala Phe 
                645                 650                 655     


Ala Asn Ser Phe Ser Arg Asn Leu Thr Leu Thr Cys Asn Leu Arg Lys 
            660                 665                 670         


Arg Ile Ile Phe Arg Lys Ile Ser Asp Val Lys Lys Glu Glu Glu Glu 
        675                 680                 685             


Arg Leu Arg Gln Lys Asn Glu Val Thr Leu Ser Ile Pro Val Asp His 
    690                 695                 700                 


Pro Val Arg Lys Leu Phe Gln Lys Phe Lys Gln Gln Lys Glu Leu Arg 
705                 710                 715                 720 


Asn Gln Gly Ser Thr Gln Gly Asp Pro Glu Arg Asn Gln Leu Gln Val 
                725                 730                 735     


Glu Ser Arg Ser Leu Gln Asn Gly Ala Ser Ile Thr Gly Thr Ser Val 
            740                 745                 750         


Val Thr Val Ser Gln Ile Thr Pro Ile Gln Thr Ser Leu Ala Tyr Val 
        755                 760                 765             


Lys Thr Ser Glu Ser Leu Lys Gln Asn Asn Arg Asp Ala Met Glu Leu 
    770                 775                 780                 


Lys Pro Asn Gly Gly Ala Asp Gln Lys Cys Leu Lys Val Asn Ser Pro 
785                 790                 795                 800 


Ile Arg Met Lys Asn Gly Asn Gly Lys Gly Trp Leu Arg Leu Lys Asn 
                805                 810                 815     


Asn Met Gly Ala His Glu Glu Lys Lys Glu Asp Trp Asn Asn Val Thr 
            820                 825                 830         


Lys Ala Glu Ser Met Gly Leu Leu Ser Glu Asp Pro Lys Ser Ser Asp 
        835                 840                 845             


Ser Glu Asn Ser Val Thr Lys Asn Pro Leu Arg Lys Thr Asp Ser Cys 
    850                 855                 860                 


Asp Ser Gly Ile Thr Lys Ser Asp Leu Arg Leu Asp Lys Ala Gly Glu 
865                 870                 875                 880 


Ala Arg Ser Pro Leu Glu His Ser Pro Ile Gln Ala Asp Ala Lys His 
                885                 890                 895     


Pro Phe Tyr Pro Ile Pro Glu Gln Ala Leu Gln Thr Thr Leu Gln Glu 
            900                 905                 910         


Val Lys His Glu Leu Lys Glu Asp Ile Gln Leu Leu Ser Cys Arg Met 
        915                 920                 925             


Thr Ala Leu Glu Lys Gln Val Ala Glu Ile Leu Lys Ile Leu Ser Glu 
    930                 935                 940                 


Lys Ser Val Pro Gln Ala Ser Ser Pro Lys Ser Gln Met Pro Leu Gln 
945                 950                 955                 960 


Val Pro Pro Gln Ile Pro Cys Gln Asp Ile Phe Ser Val Ser Arg Pro 
                965                 970                 975     


Glu Ser Pro Glu Ser Asp Lys Asp Glu Ile His Phe 
            980                 985             


<210> 55
<211> 1159
<212> PRT
<213> Homo sapiens

<400> 55
Met Pro Val Arg Arg Gly His Val Ala Pro Gln Asn Thr Phe Leu Asp 
1               5                   10                  15      


Thr Ile Ile Arg Lys Phe Glu Gly Gln Ser Arg Lys Phe Ile Ile Ala 
            20                  25                  30          


Asn Ala Arg Val Glu Asn Cys Ala Val Ile Tyr Cys Asn Asp Gly Phe 
        35                  40                  45              


Cys Glu Leu Cys Gly Tyr Ser Arg Ala Glu Val Met Gln Arg Pro Cys 
    50                  55                  60                  


Thr Cys Asp Phe Leu His Gly Pro Arg Thr Gln Arg Arg Ala Ala Ala 
65                  70                  75                  80  


Gln Ile Ala Gln Ala Leu Leu Gly Ala Glu Glu Arg Lys Val Glu Ile 
                85                  90                  95      


Ala Phe Tyr Arg Lys Asp Gly Ser Cys Phe Leu Cys Leu Val Asp Val 
            100                 105                 110         


Val Pro Val Lys Asn Glu Asp Gly Ala Val Ile Met Phe Ile Leu Asn 
        115                 120                 125             


Phe Glu Val Val Met Glu Lys Asp Met Val Gly Ser Pro Ala His Asp 
    130                 135                 140                 


Thr Asn His Arg Gly Pro Pro Thr Ser Trp Leu Ala Pro Gly Arg Ala 
145                 150                 155                 160 


Lys Thr Phe Arg Leu Lys Leu Pro Ala Leu Leu Ala Leu Thr Ala Arg 
                165                 170                 175     


Glu Ser Ser Val Arg Ser Gly Gly Ala Gly Gly Ala Gly Ala Pro Gly 
            180                 185                 190         


Ala Val Val Val Asp Val Asp Leu Thr Pro Ala Ala Pro Ser Ser Glu 
        195                 200                 205             


Ser Leu Ala Leu Asp Glu Val Thr Ala Met Asp Asn His Val Ala Gly 
    210                 215                 220                 


Leu Gly Pro Ala Glu Glu Arg Arg Ala Leu Val Gly Pro Gly Ser Pro 
225                 230                 235                 240 


Pro Arg Ser Ala Pro Gly Gln Leu Pro Ser Pro Arg Ala His Ser Leu 
                245                 250                 255     


Asn Pro Asp Ala Ser Gly Ser Ser Cys Ser Leu Ala Arg Thr Arg Ser 
            260                 265                 270         


Arg Glu Ser Cys Ala Ser Val Arg Arg Ala Ser Ser Ala Asp Asp Ile 
        275                 280                 285             


Glu Ala Met Arg Ala Gly Val Leu Pro Pro Pro Pro Arg His Ala Ser 
    290                 295                 300                 


Thr Gly Ala Met His Pro Leu Arg Ser Gly Leu Leu Asn Ser Thr Ser 
305                 310                 315                 320 


Asp Ser Asp Leu Val Arg Tyr Arg Thr Ile Ser Lys Ile Pro Gln Ile 
                325                 330                 335     


Thr Leu Asn Phe Val Asp Leu Lys Gly Asp Pro Phe Leu Ala Ser Pro 
            340                 345                 350         


Thr Ser Asp Arg Glu Ile Ile Ala Pro Lys Ile Lys Glu Arg Thr His 
        355                 360                 365             


Asn Val Thr Glu Lys Val Thr Gln Val Leu Ser Leu Gly Ala Asp Val 
    370                 375                 380                 


Leu Pro Glu Tyr Lys Leu Gln Ala Pro Arg Ile His Arg Trp Thr Ile 
385                 390                 395                 400 


Leu His Tyr Ser Pro Phe Lys Ala Val Trp Asp Trp Leu Ile Leu Leu 
                405                 410                 415     


Leu Val Ile Tyr Thr Ala Val Phe Thr Pro Tyr Ser Ala Ala Phe Leu 
            420                 425                 430         


Leu Lys Glu Thr Glu Glu Gly Pro Pro Ala Thr Glu Cys Gly Tyr Ala 
        435                 440                 445             


Cys Gln Pro Leu Ala Val Val Asp Leu Ile Val Asp Ile Met Phe Ile 
    450                 455                 460                 


Val Asp Ile Leu Ile Asn Phe Arg Thr Thr Tyr Val Asn Ala Asn Glu 
465                 470                 475                 480 


Glu Val Val Ser His Pro Gly Arg Ile Ala Val His Tyr Phe Lys Gly 
                485                 490                 495     


Trp Phe Leu Ile Asp Met Val Ala Ala Ile Pro Phe Asp Leu Leu Ile 
            500                 505                 510         


Phe Gly Ser Gly Ser Glu Glu Leu Ile Gly Leu Leu Lys Thr Ala Arg 
        515                 520                 525             


Leu Leu Arg Leu Val Arg Val Ala Arg Lys Leu Asp Arg Tyr Ser Glu 
    530                 535                 540                 


Tyr Gly Ala Ala Val Leu Phe Leu Leu Met Cys Thr Phe Ala Leu Ile 
545                 550                 555                 560 


Ala His Trp Leu Ala Cys Ile Trp Tyr Ala Ile Gly Asn Met Glu Gln 
                565                 570                 575     


Pro His Met Asp Ser Arg Ile Gly Trp Leu His Asn Leu Gly Asp Gln 
            580                 585                 590         


Ile Gly Lys Pro Tyr Asn Ser Ser Gly Leu Gly Gly Pro Ser Ile Lys 
        595                 600                 605             


Asp Lys Tyr Val Thr Ala Leu Tyr Phe Thr Phe Ser Ser Leu Thr Ser 
    610                 615                 620                 


Val Gly Phe Gly Asn Val Ser Pro Asn Thr Asn Ser Glu Lys Ile Phe 
625                 630                 635                 640 


Ser Ile Cys Val Met Leu Ile Gly Ser Leu Met Tyr Ala Ser Ile Phe 
                645                 650                 655     


Gly Asn Val Ser Ala Ile Ile Gln Arg Leu Tyr Ser Gly Thr Ala Arg 
            660                 665                 670         


Tyr His Thr Gln Met Leu Arg Val Arg Glu Phe Ile Arg Phe His Gln 
        675                 680                 685             


Ile Pro Asn Pro Leu Arg Gln Arg Leu Glu Glu Tyr Phe Gln His Ala 
    690                 695                 700                 


Trp Ser Tyr Thr Asn Gly Ile Asp Met Asn Ala Val Leu Lys Gly Phe 
705                 710                 715                 720 


Pro Glu Cys Leu Gln Ala Asp Ile Cys Leu His Leu Asn Arg Ser Leu 
                725                 730                 735     


Leu Gln His Cys Lys Pro Phe Arg Gly Ala Thr Lys Gly Cys Leu Arg 
            740                 745                 750         


Ala Leu Ala Met Lys Phe Lys Thr Thr His Ala Pro Pro Gly Asp Thr 
        755                 760                 765             


Leu Val His Ala Gly Asp Leu Leu Thr Ala Leu Tyr Phe Ile Ser Arg 
    770                 775                 780                 


Gly Ser Ile Glu Ile Leu Arg Gly Asp Val Val Val Ala Ile Leu Gly 
785                 790                 795                 800 


Lys Asn Asp Ile Phe Gly Glu Pro Leu Asn Leu Tyr Ala Arg Pro Gly 
                805                 810                 815     


Lys Ser Asn Gly Asp Val Arg Ala Leu Thr Tyr Cys Asp Leu His Lys 
            820                 825                 830         


Ile His Arg Asp Asp Leu Leu Glu Val Leu Asp Met Tyr Pro Glu Phe 
        835                 840                 845             


Ser Asp His Phe Trp Ser Ser Leu Glu Ile Thr Phe Asn Leu Arg Asp 
    850                 855                 860                 


Thr Asn Met Ile Pro Gly Ser Pro Gly Ser Thr Glu Leu Glu Gly Gly 
865                 870                 875                 880 


Phe Ser Arg Gln Arg Lys Arg Lys Leu Ser Phe Arg Arg Arg Thr Asp 
                885                 890                 895     


Lys Asp Thr Glu Gln Pro Gly Glu Val Ser Ala Leu Gly Pro Gly Arg 
            900                 905                 910         


Ala Gly Ala Gly Pro Ser Ser Arg Gly Arg Pro Gly Gly Pro Trp Gly 
        915                 920                 925             


Glu Ser Pro Ser Ser Gly Pro Ser Ser Pro Glu Ser Ser Glu Asp Glu 
    930                 935                 940                 


Gly Pro Gly Arg Ser Ser Ser Pro Leu Arg Leu Val Pro Phe Ser Ser 
945                 950                 955                 960 


Pro Arg Pro Pro Gly Glu Pro Pro Gly Gly Glu Pro Leu Met Glu Asp 
                965                 970                 975     


Cys Glu Lys Ser Ser Asp Thr Cys Asn Pro Leu Ser Gly Ala Phe Ser 
            980                 985                 990         


Gly Val Ser Asn Ile Phe Ser Phe  Trp Gly Asp Ser Arg  Gly Arg Gln 
        995                 1000                 1005             


Tyr Gln  Glu Leu Pro Arg Cys  Pro Ala Pro Thr Pro  Ser Leu Leu 
    1010                 1015                 1020             


Asn Ile  Pro Leu Ser Ser Pro  Gly Arg Arg Pro Arg  Gly Asp Val 
    1025                 1030                 1035             


Glu Ser  Arg Leu Asp Ala Leu  Gln Arg Gln Leu Asn  Arg Leu Glu 
    1040                 1045                 1050             


Thr Arg  Leu Ser Ala Asp Met  Ala Thr Val Leu Gln  Leu Leu Gln 
    1055                 1060                 1065             


Arg Gln  Met Thr Leu Val Pro  Pro Ala Tyr Ser Ala  Val Thr Thr 
    1070                 1075                 1080             


Pro Gly  Pro Gly Pro Thr Ser  Thr Ser Pro Leu Leu  Pro Val Ser 
    1085                 1090                 1095             


Pro Leu  Pro Thr Leu Thr Leu  Asp Ser Leu Ser Gln  Val Ser Gln 
    1100                 1105                 1110             


Phe Met  Ala Cys Glu Glu Leu  Pro Pro Gly Ala Pro  Glu Leu Pro 
    1115                 1120                 1125             


Gln Glu  Gly Pro Thr Arg Arg  Leu Ser Leu Pro Gly  Gln Leu Gly 
    1130                 1135                 1140             


Ala Leu  Thr Ser Gln Pro Leu  His Arg His Gly Ser  Asp Pro Gly 
    1145                 1150                 1155             


Ser 
    


<210> 56
<211> 994
<212> PRT
<213> Homo sapiens

<400> 56
Met Pro Val Arg Arg Gly His Val Ala Pro Gln Asn Thr Tyr Leu Asp 
1               5                   10                  15      


Thr Ile Ile Arg Lys Phe Glu Gly Gln Ser Arg Lys Phe Leu Ile Ala 
            20                  25                  30          


Asn Ala Gln Met Glu Asn Cys Ala Ile Ile Tyr Cys Asn Asp Gly Phe 
        35                  40                  45              


Cys Glu Leu Phe Gly Tyr Ser Arg Val Glu Val Met Gln Gln Pro Cys 
    50                  55                  60                  


Thr Cys Asp Phe Leu Thr Gly Pro Asn Thr Pro Ser Ser Ala Val Ser 
65                  70                  75                  80  


Arg Leu Ala Gln Ala Leu Leu Gly Ala Glu Glu Cys Lys Val Asp Ile 
                85                  90                  95      


Leu Tyr Tyr Arg Lys Asp Ala Ser Ser Phe Arg Cys Leu Val Asp Val 
            100                 105                 110         


Val Pro Val Lys Asn Glu Asp Gly Ala Val Ile Met Phe Ile Leu Asn 
        115                 120                 125             


Phe Glu Asp Leu Ala Gln Leu Leu Ala Lys Cys Ser Ser Arg Ser Leu 
    130                 135                 140                 


Ser Gln Arg Leu Leu Ser Gln Ser Phe Leu Gly Ser Glu Gly Ser His 
145                 150                 155                 160 


Gly Arg Pro Gly Gly Pro Gly Pro Gly Thr Gly Arg Gly Lys Tyr Arg 
                165                 170                 175     


Thr Ile Ser Gln Ile Pro Gln Phe Thr Leu Asn Phe Val Glu Phe Asn 
            180                 185                 190         


Leu Glu Lys His Arg Ser Ser Ser Thr Thr Glu Ile Glu Ile Ile Ala 
        195                 200                 205             


Pro His Lys Val Val Glu Arg Thr Gln Asn Val Thr Glu Lys Val Thr 
    210                 215                 220                 


Gln Val Leu Ser Leu Gly Ala Asp Val Leu Pro Glu Tyr Lys Leu Gln 
225                 230                 235                 240 


Ala Pro Arg Ile His Arg Trp Thr Ile Leu His Tyr Ser Pro Phe Lys 
                245                 250                 255     


Ala Val Trp Asp Trp Leu Ile Leu Leu Leu Val Ile Tyr Thr Ala Val 
            260                 265                 270         


Phe Thr Pro Tyr Ser Ala Ala Phe Leu Leu Ser Asp Gln Asp Glu Ser 
        275                 280                 285             


Arg Arg Gly Ala Cys Ser Tyr Thr Cys Ser Pro Leu Thr Val Val Asp 
    290                 295                 300                 


Leu Ile Val Asp Ile Met Phe Val Val Asp Ile Val Ile Asn Phe Arg 
305                 310                 315                 320 


Thr Thr Tyr Val Asn Thr Asn Asp Glu Val Val Ser His Pro Arg Arg 
                325                 330                 335     


Ile Ala Val His Tyr Phe Lys Gly Trp Phe Leu Ile Asp Met Val Ala 
            340                 345                 350         


Ala Ile Pro Phe Asp Leu Leu Ile Phe Arg Thr Gly Ser Asp Glu Thr 
        355                 360                 365             


Thr Thr Leu Ile Gly Leu Leu Lys Thr Ala Arg Leu Leu Arg Leu Val 
    370                 375                 380                 


Arg Val Ala Arg Lys Leu Asp Arg Tyr Ser Glu Tyr Gly Ala Ala Val 
385                 390                 395                 400 


Leu Phe Leu Leu Met Cys Thr Phe Ala Leu Ile Ala His Trp Leu Ala 
                405                 410                 415     


Cys Ile Trp Tyr Ala Ile Gly Asn Val Glu Arg Pro Tyr Leu Glu His 
            420                 425                 430         


Lys Ile Gly Trp Leu Asp Ser Leu Gly Val Gln Leu Gly Lys Arg Tyr 
        435                 440                 445             


Asn Gly Ser Asp Pro Ala Ser Gly Pro Ser Val Gln Asp Lys Tyr Val 
    450                 455                 460                 


Thr Ala Leu Tyr Phe Thr Phe Ser Ser Leu Thr Ser Val Gly Phe Gly 
465                 470                 475                 480 


Asn Val Ser Pro Asn Thr Asn Ser Glu Lys Val Phe Ser Ile Cys Val 
                485                 490                 495     


Met Leu Ile Gly Ser Leu Met Tyr Ala Ser Ile Phe Gly Asn Val Ser 
            500                 505                 510         


Ala Ile Ile Gln Arg Leu Tyr Ser Gly Thr Ala Arg Tyr His Thr Gln 
        515                 520                 525             


Met Leu Arg Val Lys Glu Phe Ile Arg Phe His Gln Ile Pro Asn Pro 
    530                 535                 540                 


Leu Arg Gln Arg Leu Glu Glu Tyr Phe Gln His Ala Trp Ser Tyr Thr 
545                 550                 555                 560 


Asn Gly Ile Asp Met Asn Ala Val Leu Lys Gly Phe Pro Glu Cys Leu 
                565                 570                 575     


Gln Ala Asp Ile Cys Leu His Leu His Arg Ala Leu Leu Gln His Cys 
            580                 585                 590         


Pro Ala Phe Ser Gly Ala Gly Lys Gly Cys Leu Arg Ala Leu Ala Val 
        595                 600                 605             


Lys Phe Lys Thr Thr His Ala Pro Pro Gly Asp Thr Leu Val His Leu 
    610                 615                 620                 


Gly Asp Val Leu Ser Thr Leu Tyr Phe Ile Ser Arg Gly Ser Ile Glu 
625                 630                 635                 640 


Ile Leu Arg Asp Asp Val Val Val Ala Ile Leu Gly Lys Asn Asp Ile 
                645                 650                 655     


Phe Gly Glu Pro Val Ser Leu His Ala Gln Pro Gly Lys Ser Ser Ala 
            660                 665                 670         


Asp Val Arg Ala Leu Thr Tyr Cys Asp Leu His Lys Ile Gln Arg Ala 
        675                 680                 685             


Asp Leu Leu Glu Val Leu Asp Met Tyr Pro Ala Phe Ala Glu Ser Phe 
    690                 695                 700                 


Trp Ser Lys Leu Glu Val Thr Phe Asn Leu Arg Asp Ala Ala Gly Gly 
705                 710                 715                 720 


Leu His Ser Ser Pro Arg Gln Ala Pro Gly Ser Gln Asp His Gln Gly 
                725                 730                 735     


Phe Phe Leu Ser Asp Asn Gln Ser Gly Ser Pro His Glu Leu Gly Pro 
            740                 745                 750         


Gln Phe Pro Ser Lys Gly Tyr Ser Leu Leu Gly Pro Gly Ser Gln Asn 
        755                 760                 765             


Ser Met Gly Ala Gly Pro Cys Ala Pro Gly His Pro Asp Ala Ala Pro 
    770                 775                 780                 


Pro Leu Ser Ile Ser Asp Ala Ser Gly Leu Trp Pro Glu Leu Leu Gln 
785                 790                 795                 800 


Glu Met Pro Pro Arg His Ser Pro Gln Ser Pro Gln Glu Asp Pro Asp 
                805                 810                 815     


Cys Trp Pro Leu Lys Leu Gly Ser Arg Leu Glu Gln Leu Gln Ala Gln 
            820                 825                 830         


Met Asn Arg Leu Glu Ser Arg Val Ser Ser Asp Leu Ser Arg Ile Leu 
        835                 840                 845             


Gln Leu Leu Gln Lys Pro Met Pro Gln Gly His Ala Ser Tyr Ile Leu 
    850                 855                 860                 


Glu Ala Pro Ala Ser Asn Asp Leu Ala Leu Val Pro Ile Ala Ser Glu 
865                 870                 875                 880 


Thr Thr Ser Pro Gly Pro Arg Leu Pro Gln Gly Phe Leu Pro Pro Ala 
                885                 890                 895     


Gln Thr Pro Ser Tyr Gly Asp Leu Asp Asp Cys Ser Pro Lys His Arg 
            900                 905                 910         


Asn Ser Ser Pro Arg Met Pro His Leu Ala Val Ala Thr Asp Lys Thr 
        915                 920                 925             


Leu Ala Pro Ser Ser Glu Gln Glu Gln Pro Glu Gly Leu Trp Pro Pro 
    930                 935                 940                 


Leu Ala Ser Pro Leu His Pro Leu Glu Val Gln Gly Leu Ile Cys Gly 
945                 950                 955                 960 


Pro Cys Phe Ser Ser Leu Pro Glu His Leu Gly Ser Val Pro Lys Gln 
                965                 970                 975     


Leu Asp Phe Gln Arg His Gly Ser Asp Pro Gly Phe Ala Gly Ser Trp 
            980                 985                 990         


Gly His 
        


<210> 57
<211> 1196
<212> PRT
<213> Homo sapiens

<400> 57
Met Pro Val Arg Arg Gly His Val Ala Pro Gln Asn Thr Phe Leu Gly 
1               5                   10                  15      


Thr Ile Ile Arg Lys Phe Glu Gly Gln Asn Lys Lys Phe Ile Ile Ala 
            20                  25                  30          


Asn Ala Arg Val Gln Asn Cys Ala Ile Ile Tyr Cys Asn Asp Gly Phe 
        35                  40                  45              


Cys Glu Met Thr Gly Phe Ser Arg Pro Asp Val Met Gln Lys Pro Cys 
    50                  55                  60                  


Thr Cys Asp Phe Leu His Gly Pro Glu Thr Lys Arg His Asp Ile Ala 
65                  70                  75                  80  


Gln Ile Ala Gln Ala Leu Leu Gly Ser Glu Glu Arg Lys Val Glu Val 
                85                  90                  95      


Thr Tyr Tyr His Lys Asn Gly Ser Thr Phe Ile Cys Asn Thr His Ile 
            100                 105                 110         


Ile Pro Val Lys Asn Gln Glu Gly Val Ala Met Met Phe Ile Ile Asn 
        115                 120                 125             


Phe Glu Tyr Val Thr Asp Asn Glu Asn Ala Ala Thr Pro Glu Arg Val 
    130                 135                 140                 


Asn Pro Ile Leu Pro Ile Lys Thr Val Asn Arg Lys Phe Phe Gly Phe 
145                 150                 155                 160 


Lys Phe Pro Gly Leu Arg Val Leu Thr Tyr Arg Lys Gln Ser Leu Pro 
                165                 170                 175     


Gln Glu Asp Pro Asp Val Val Val Ile Asp Ser Ser Lys His Ser Asp 
            180                 185                 190         


Asp Ser Val Ala Met Lys His Phe Lys Ser Pro Thr Lys Glu Ser Cys 
        195                 200                 205             


Ser Pro Ser Glu Ala Asp Asp Thr Lys Ala Leu Ile Gln Pro Ser Lys 
    210                 215                 220                 


Cys Ser Pro Leu Val Asn Ile Ser Gly Pro Leu Asp His Ser Ser Pro 
225                 230                 235                 240 


Lys Arg Gln Trp Asp Arg Leu Tyr Pro Asp Met Leu Gln Ser Ser Ser 
                245                 250                 255     


Gln Leu Ser His Ser Arg Ser Arg Glu Ser Leu Cys Ser Ile Arg Arg 
            260                 265                 270         


Ala Ser Ser Val His Asp Ile Glu Gly Phe Gly Val His Pro Lys Asn 
        275                 280                 285             


Ile Phe Arg Asp Arg His Ala Ser Glu Asp Asn Gly Arg Asn Val Lys 
    290                 295                 300                 


Gly Pro Phe Asn His Ile Lys Ser Ser Leu Leu Gly Ser Thr Ser Asp 
305                 310                 315                 320 


Ser Asn Leu Asn Lys Tyr Ser Thr Ile Asn Lys Ile Pro Gln Leu Thr 
                325                 330                 335     


Leu Asn Phe Ser Glu Val Lys Thr Glu Lys Lys Asn Ser Ser Pro Pro 
            340                 345                 350         


Ser Ser Asp Lys Thr Ile Ile Ala Pro Lys Val Lys Asp Arg Thr His 
        355                 360                 365             


Asn Val Thr Glu Lys Val Thr Gln Val Leu Ser Leu Gly Ala Asp Val 
    370                 375                 380                 


Leu Pro Glu Tyr Lys Leu Gln Thr Pro Arg Ile Asn Lys Phe Thr Ile 
385                 390                 395                 400 


Leu His Tyr Ser Pro Phe Lys Ala Val Trp Asp Trp Leu Ile Leu Leu 
                405                 410                 415     


Leu Val Ile Tyr Thr Ala Ile Phe Thr Pro Tyr Ser Ala Ala Phe Leu 
            420                 425                 430         


Leu Asn Asp Arg Glu Glu Gln Lys Arg Arg Glu Cys Gly Tyr Ser Cys 
        435                 440                 445             


Ser Pro Leu Asn Val Val Asp Leu Ile Val Asp Ile Met Phe Ile Ile 
    450                 455                 460                 


Asp Ile Leu Ile Asn Phe Arg Thr Thr Tyr Val Asn Gln Asn Glu Glu 
465                 470                 475                 480 


Val Val Ser Asp Pro Ala Lys Ile Ala Ile His Tyr Phe Lys Gly Trp 
                485                 490                 495     


Phe Leu Ile Asp Met Val Ala Ala Ile Pro Phe Asp Leu Leu Ile Phe 
            500                 505                 510         


Gly Ser Gly Ser Asp Glu Thr Thr Thr Leu Ile Gly Leu Leu Lys Thr 
        515                 520                 525             


Ala Arg Leu Leu Arg Leu Val Arg Val Ala Arg Lys Leu Asp Arg Tyr 
    530                 535                 540                 


Ser Glu Tyr Gly Ala Ala Val Leu Met Leu Leu Met Cys Ile Phe Ala 
545                 550                 555                 560 


Leu Ile Ala His Trp Leu Ala Cys Ile Trp Tyr Ala Ile Gly Asn Val 
                565                 570                 575     


Glu Arg Pro Tyr Leu Thr Asp Lys Ile Gly Trp Leu Asp Ser Leu Gly 
            580                 585                 590         


Gln Gln Ile Gly Lys Arg Tyr Asn Asp Ser Asp Ser Ser Ser Gly Pro 
        595                 600                 605             


Ser Ile Lys Asp Lys Tyr Val Thr Ala Leu Tyr Phe Thr Phe Ser Ser 
    610                 615                 620                 


Leu Thr Ser Val Gly Phe Gly Asn Val Ser Pro Asn Thr Asn Ser Glu 
625                 630                 635                 640 


Lys Ile Phe Ser Ile Cys Val Met Leu Ile Gly Ser Leu Met Tyr Ala 
                645                 650                 655     


Ser Ile Phe Gly Asn Val Ser Ala Ile Ile Gln Arg Leu Tyr Ser Gly 
            660                 665                 670         


Thr Ala Arg Tyr His Met Gln Met Leu Arg Val Lys Glu Phe Ile Arg 
        675                 680                 685             


Phe His Gln Ile Pro Asn Pro Leu Arg Gln Arg Leu Glu Glu Tyr Phe 
    690                 695                 700                 


Gln His Ala Trp Thr Tyr Thr Asn Gly Ile Asp Met Asn Met Val Leu 
705                 710                 715                 720 


Lys Gly Phe Pro Glu Cys Leu Gln Ala Asp Ile Cys Leu His Leu Asn 
                725                 730                 735     


Gln Thr Leu Leu Gln Asn Cys Lys Ala Phe Arg Gly Ala Ser Lys Gly 
            740                 745                 750         


Cys Leu Arg Ala Leu Ala Met Lys Phe Lys Thr Thr His Ala Pro Pro 
        755                 760                 765             


Gly Asp Thr Leu Val His Cys Gly Asp Val Leu Thr Ala Leu Tyr Phe 
    770                 775                 780                 


Leu Ser Arg Gly Ser Ile Glu Ile Leu Lys Asp Asp Ile Val Val Ala 
785                 790                 795                 800 


Ile Leu Gly Lys Asn Asp Ile Phe Gly Glu Met Val His Leu Tyr Ala 
                805                 810                 815     


Lys Pro Gly Lys Ser Asn Ala Asp Val Arg Ala Leu Thr Tyr Cys Asp 
            820                 825                 830         


Leu His Lys Ile Gln Arg Glu Asp Leu Leu Glu Val Leu Asp Met Tyr 
        835                 840                 845             


Pro Glu Phe Ser Asp His Phe Leu Thr Asn Leu Glu Leu Thr Phe Asn 
    850                 855                 860                 


Leu Arg His Glu Ser Ala Lys Ala Asp Leu Leu Arg Ser Gln Ser Met 
865                 870                 875                 880 


Asn Asp Ser Glu Gly Asp Asn Cys Lys Leu Arg Arg Arg Lys Leu Ser 
                885                 890                 895     


Phe Glu Ser Glu Gly Glu Lys Glu Asn Ser Thr Asn Asp Pro Glu Asp 
            900                 905                 910         


Ser Ala Asp Thr Ile Arg His Tyr Gln Ser Ser Lys Arg His Phe Glu 
        915                 920                 925             


Glu Lys Lys Ser Arg Ser Ser Ser Phe Ile Ser Ser Ile Asp Asp Glu 
    930                 935                 940                 


Gln Lys Pro Leu Phe Ser Gly Ile Val Asp Ser Ser Pro Gly Ile Gly 
945                 950                 955                 960 


Lys Ala Ser Gly Leu Asp Phe Glu Glu Thr Val Pro Thr Ser Gly Arg 
                965                 970                 975     


Met His Ile Asp Lys Arg Ser His Ser Cys Lys Asp Ile Thr Asp Met 
            980                 985                 990         


Arg Ser Trp Glu Arg Glu Asn Ala  His Pro Gln Pro Glu  Asp Ser Ser 
        995                 1000                 1005             


Pro Ser  Ala Leu Gln Arg Ala  Ala Trp Gly Ile Ser  Glu Thr Glu 
    1010                 1015                 1020             


Ser Asp  Leu Thr Tyr Gly Glu  Val Glu Gln Arg Leu  Asp Leu Leu 
    1025                 1030                 1035             


Gln Glu  Gln Leu Asn Arg Leu  Glu Ser Gln Met Thr  Thr Asp Ile 
    1040                 1045                 1050             


Gln Thr  Ile Leu Gln Leu Leu  Gln Lys Gln Thr Thr  Val Val Pro 
    1055                 1060                 1065             


Pro Ala  Tyr Ser Met Val Thr  Ala Gly Ser Glu Tyr  Gln Arg Pro 
    1070                 1075                 1080             


Ile Ile  Gln Leu Met Arg Thr  Ser Gln Pro Glu Ala  Ser Ile Lys 
    1085                 1090                 1095             


Thr Asp  Arg Ser Phe Ser Pro  Ser Ser Gln Cys Pro  Glu Phe Leu 
    1100                 1105                 1110             


Asp Leu  Glu Lys Ser Lys Leu  Lys Ser Lys Glu Ser  Leu Ser Ser 
    1115                 1120                 1125             


Gly Val  His Leu Asn Thr Ala  Ser Glu Asp Asn Leu  Thr Ser Leu 
    1130                 1135                 1140             


Leu Lys  Gln Asp Ser Asp Leu  Ser Leu Glu Leu His  Leu Arg Gln 
    1145                 1150                 1155             


Arg Lys  Thr Tyr Val His Pro  Ile Arg His Pro Ser  Leu Pro Asp 
    1160                 1165                 1170             


Ser Ser  Leu Ser Thr Val Gly  Ile Val Gly Leu His  Arg His Val 
    1175                 1180                 1185             


Ser Asp  Pro Gly Leu Pro Gly  Lys 
    1190                 1195     


<210> 58
<211> 1107
<212> PRT
<213> Homo sapiens

<400> 58
Met Pro Val Met Lys Gly Leu Leu Ala Pro Gln Asn Thr Phe Leu Asp 
1               5                   10                  15      


Thr Ile Ala Thr Arg Phe Asp Gly Thr His Ser Asn Phe Ile Leu Ala 
            20                  25                  30          


Asn Ala Gln Val Ala Lys Gly Phe Pro Ile Val Tyr Cys Ser Asp Gly 
        35                  40                  45              


Phe Cys Glu Leu Ala Gly Phe Ala Arg Thr Glu Val Met Gln Lys Ser 
    50                  55                  60                  


Cys Ser Cys Lys Phe Leu Phe Gly Val Glu Thr Asn Glu Gln Leu Met 
65                  70                  75                  80  


Leu Gln Ile Glu Lys Ser Leu Glu Glu Lys Thr Glu Phe Lys Gly Glu 
                85                  90                  95      


Ile Met Phe Tyr Lys Lys Asn Gly Ser Pro Phe Trp Cys Leu Leu Asp 
            100                 105                 110         


Ile Val Pro Ile Lys Asn Glu Lys Gly Asp Val Val Leu Phe Leu Ala 
        115                 120                 125             


Ser Phe Lys Asp Ile Thr Asp Thr Lys Val Lys Ile Thr Pro Glu Asp 
    130                 135                 140                 


Lys Lys Glu Asp Lys Val Lys Gly Arg Ser Arg Ala Gly Thr His Phe 
145                 150                 155                 160 


Asp Ser Ala Arg Arg Arg Ser Arg Ala Val Leu Tyr His Ile Ser Gly 
                165                 170                 175     


His Leu Gln Arg Arg Glu Lys Asn Lys Leu Lys Ile Asn Asn Asn Val 
            180                 185                 190         


Phe Val Asp Lys Pro Ala Phe Pro Glu Tyr Lys Val Ser Asp Ala Lys 
        195                 200                 205             


Lys Ser Lys Phe Ile Leu Leu His Phe Ser Thr Phe Lys Ala Gly Trp 
    210                 215                 220                 


Asp Trp Leu Ile Leu Leu Ala Thr Phe Tyr Val Ala Val Thr Val Pro 
225                 230                 235                 240 


Tyr Asn Val Cys Phe Ile Gly Asn Asp Asp Leu Ser Thr Thr Arg Ser 
                245                 250                 255     


Thr Thr Val Ser Asp Ile Ala Val Glu Ile Leu Phe Ile Ile Asp Ile 
            260                 265                 270         


Ile Leu Asn Phe Arg Thr Thr Tyr Val Ser Lys Ser Gly Gln Val Ile 
        275                 280                 285             


Phe Glu Ala Arg Ser Ile Cys Ile His Tyr Val Thr Thr Trp Phe Ile 
    290                 295                 300                 


Ile Asp Leu Ile Ala Ala Leu Pro Phe Asp Leu Leu Tyr Ala Phe Asn 
305                 310                 315                 320 


Val Thr Val Val Ser Leu Val His Leu Leu Lys Thr Val Arg Leu Leu 
                325                 330                 335     


Arg Leu Leu Arg Leu Leu Gln Lys Leu Asp Arg Tyr Ser Gln His Ser 
            340                 345                 350         


Thr Ile Val Leu Thr Leu Leu Met Ser Met Phe Ala Leu Leu Ala His 
        355                 360                 365             


Trp Met Ala Cys Ile Trp Tyr Val Ile Gly Lys Met Glu Arg Glu Asp 
    370                 375                 380                 


Asn Ser Leu Leu Lys Trp Glu Val Gly Trp Leu His Glu Leu Gly Lys 
385                 390                 395                 400 


Arg Leu Glu Ser Pro Tyr Tyr Gly Asn Asn Thr Leu Gly Gly Pro Ser 
                405                 410                 415     


Ile Arg Ser Ala Tyr Ile Ala Ala Leu Tyr Phe Thr Leu Ser Ser Leu 
            420                 425                 430         


Thr Ser Val Gly Phe Gly Asn Val Ser Ala Asn Thr Asp Ala Glu Lys 
        435                 440                 445             


Ile Phe Ser Ile Cys Thr Met Leu Ile Gly Ala Leu Met His Ala Leu 
    450                 455                 460                 


Val Phe Gly Asn Val Thr Ala Ile Ile Gln Arg Met Tyr Ser Arg Trp 
465                 470                 475                 480 


Ser Leu Tyr His Thr Arg Thr Lys Asp Leu Lys Asp Phe Ile Arg Val 
                485                 490                 495     


His His Leu Pro Gln Gln Leu Lys Gln Arg Met Leu Glu Tyr Phe Gln 
            500                 505                 510         


Thr Thr Trp Ser Val Asn Asn Gly Ile Asp Ser Asn Glu Leu Leu Lys 
        515                 520                 525             


Asp Phe Pro Asp Glu Leu Arg Ser Asp Ile Thr Met His Leu Asn Lys 
    530                 535                 540                 


Glu Ile Leu Gln Leu Ser Leu Phe Glu Cys Ala Ser Arg Gly Cys Leu 
545                 550                 555                 560 


Arg Ser Leu Ser Leu His Ile Lys Thr Ser Phe Cys Ala Pro Gly Glu 
                565                 570                 575     


Tyr Leu Leu Arg Gln Gly Asp Ala Leu Gln Ala Ile Tyr Phe Val Cys 
            580                 585                 590         


Ser Gly Ser Met Glu Val Leu Lys Asp Ser Met Val Leu Ala Ile Leu 
        595                 600                 605             


Gly Lys Gly Asp Leu Ile Gly Ala Asn Leu Ser Ile Lys Asp Gln Val 
    610                 615                 620                 


Ile Lys Thr Asn Ala Asp Val Lys Ala Leu Thr Tyr Cys Asp Leu Gln 
625                 630                 635                 640 


Cys Ile Ile Leu Lys Gly Leu Phe Glu Val Leu Asp Leu Tyr Pro Glu 
                645                 650                 655     


Tyr Ala His Lys Phe Val Glu Asp Ile Gln His Asp Leu Thr Tyr Asn 
            660                 665                 670         


Leu Arg Glu Gly His Glu Ser Asp Val Ile Ser Arg Leu Ser Asn Lys 
        675                 680                 685             


Ser Met Val Ser Gln Ser Glu Pro Lys Gly Asn Gly Asn Ile Asn Lys 
    690                 695                 700                 


Arg Leu Pro Ser Ile Val Glu Asp Glu Glu Glu Glu Glu Glu Gly Glu 
705                 710                 715                 720 


Glu Glu Glu Ala Val Ser Leu Ser Pro Ile Cys Thr Arg Gly Ser Ser 
                725                 730                 735     


Ser Arg Asn Lys Lys Val Gly Ser Asn Lys Ala Tyr Leu Gly Leu Ser 
            740                 745                 750         


Leu Lys Gln Leu Ala Ser Gly Thr Val Pro Phe His Ser Pro Ile Arg 
        755                 760                 765             


Val Ser Arg Ser Asn Ser Pro Lys Thr Lys Gln Glu Ile Asp Pro Pro 
    770                 775                 780                 


Asn His Asn Lys Arg Lys Glu Lys Asn Leu Lys Leu Gln Leu Ser Thr 
785                 790                 795                 800 


Leu Asn Asn Ala Gly Pro Pro Asp Leu Ser Pro Arg Ile Val Asp Gly 
                805                 810                 815     


Ile Glu Asp Gly Asn Ser Ser Glu Glu Ser Gln Thr Phe Asp Phe Gly 
            820                 825                 830         


Ser Glu Arg Ile Arg Ser Glu Pro Arg Ile Ser Pro Pro Leu Gly Asp 
        835                 840                 845             


Pro Glu Ile Gly Ala Ala Val Leu Phe Ile Lys Ala Glu Glu Thr Lys 
    850                 855                 860                 


Gln Gln Ile Asn Lys Leu Asn Ser Glu Val Thr Thr Leu Thr Gln Glu 
865                 870                 875                 880 


Val Ser Gln Leu Gly Lys Asp Met Arg Asn Val Ile Gln Leu Leu Glu 
                885                 890                 895     


Asn Val Leu Ser Pro Gln Gln Pro Ser Arg Phe Cys Ser Leu His Ser 
            900                 905                 910         


Thr Ser Val Cys Pro Ser Arg Glu Ser Leu Gln Thr Arg Thr Ser Trp 
        915                 920                 925             


Ser Ala His Gln Pro Cys Leu His Leu Gln Thr Gly Gly Ala Ala Tyr 
    930                 935                 940                 


Thr Gln Ala Gln Leu Cys Ser Ser Asn Ile Thr Ser Asp Ile Trp Ser 
945                 950                 955                 960 


Val Asp Pro Ser Ser Val Gly Ser Ser Pro Gln Arg Thr Gly Ala His 
                965                 970                 975     


Glu Gln Asn Pro Ala Asp Ser Glu Leu Tyr His Ser Pro Ser Leu Asp 
            980                 985                 990         


Tyr Ser Pro Ser His Tyr Gln Val  Val Gln Glu Gly His  Leu Gln Phe 
        995                 1000                 1005             


Leu Arg  Cys Ile Ser Pro His  Ser Asp Ser Thr Leu  Thr Pro Leu 
    1010                 1015                 1020             


Gln Ser  Ile Ser Ala Thr Leu  Ser Ser Ser Val Cys  Ser Ser Ser 
    1025                 1030                 1035             


Glu Thr  Ser Leu His Leu Val  Leu Pro Ser Arg Ser  Glu Glu Gly 
    1040                 1045                 1050             


Ser Phe  Ser Gln Gly Thr Val  Ser Ser Phe Ser Leu  Glu Asn Leu 
    1055                 1060                 1065             


Pro Gly  Ser Trp Asn Gln Glu  Gly Met Ala Ser Ala  Ser Thr Lys 
    1070                 1075                 1080             


Pro Leu  Glu Asn Leu Pro Leu  Glu Val Val Thr Ser  Thr Ala Glu 
    1085                 1090                 1095             


Val Lys  Asp Asn Lys Ala Ile  Asn Val 
    1100                 1105         


<210> 59
<211> 1083
<212> PRT
<213> Homo sapiens

<400> 59
Met Pro Ala Met Arg Gly Leu Leu Ala Pro Gln Asn Thr Phe Leu Asp 
1               5                   10                  15      


Thr Ile Ala Thr Arg Phe Asp Gly Thr His Ser Asn Phe Val Leu Gly 
            20                  25                  30          


Asn Ala Gln Val Ala Gly Leu Phe Pro Val Val Tyr Cys Ser Asp Gly 
        35                  40                  45              


Phe Cys Asp Leu Thr Gly Phe Ser Arg Ala Glu Val Met Gln Arg Gly 
    50                  55                  60                  


Cys Ala Cys Ser Phe Leu Tyr Gly Pro Asp Thr Ser Glu Leu Val Arg 
65                  70                  75                  80  


Gln Gln Ile Arg Lys Ala Leu Asp Glu His Lys Glu Phe Lys Ala Glu 
                85                  90                  95      


Leu Ile Leu Tyr Arg Lys Ser Gly Leu Pro Phe Trp Cys Leu Leu Asp 
            100                 105                 110         


Val Ile Pro Ile Lys Asn Glu Lys Gly Glu Val Ala Leu Phe Leu Val 
        115                 120                 125             


Ser His Lys Asp Ile Ser Glu Thr Lys Asn Arg Gly Gly Pro Asp Arg 
    130                 135                 140                 


Trp Lys Glu Thr Gly Gly Gly Arg Arg Arg Tyr Gly Arg Ala Arg Ser 
145                 150                 155                 160 


Lys Gly Phe Asn Ala Asn Arg Arg Arg Ser Arg Ala Val Leu Tyr His 
                165                 170                 175     


Leu Ser Gly His Leu Gln Lys Gln Pro Lys Gly Lys His Lys Leu Asn 
            180                 185                 190         


Lys Gly Val Phe Gly Glu Lys Pro Asn Leu Pro Glu Tyr Lys Val Ala 
        195                 200                 205             


Ala Ile Arg Lys Ser Pro Phe Ile Leu Leu His Cys Gly Ala Leu Arg 
    210                 215                 220                 


Ala Thr Trp Asp Gly Phe Ile Leu Leu Ala Thr Leu Tyr Val Ala Val 
225                 230                 235                 240 


Thr Val Pro Tyr Ser Val Cys Val Ser Thr Ala Arg Glu Pro Ser Ala 
                245                 250                 255     


Ala Arg Gly Pro Pro Ser Val Cys Asp Leu Ala Val Glu Val Leu Phe 
            260                 265                 270         


Ile Leu Asp Ile Val Leu Asn Phe Arg Thr Thr Phe Val Ser Lys Ser 
        275                 280                 285             


Gly Gln Val Val Phe Ala Pro Lys Ser Ile Cys Leu His Tyr Val Thr 
    290                 295                 300                 


Thr Trp Phe Leu Leu Asp Val Ile Ala Ala Leu Pro Phe Asp Leu Leu 
305                 310                 315                 320 


His Ala Phe Lys Val Asn Val Tyr Phe Gly Ala His Leu Leu Lys Thr 
                325                 330                 335     


Val Arg Leu Leu Arg Leu Leu Arg Leu Leu Pro Arg Leu Asp Arg Tyr 
            340                 345                 350         


Ser Gln Tyr Ser Ala Val Val Leu Thr Leu Leu Met Ala Val Phe Ala 
        355                 360                 365             


Leu Leu Ala His Trp Val Ala Cys Val Trp Phe Tyr Ile Gly Gln Arg 
    370                 375                 380                 


Glu Ile Glu Ser Ser Glu Ser Glu Leu Pro Glu Ile Gly Trp Leu Gln 
385                 390                 395                 400 


Glu Leu Ala Arg Arg Leu Glu Thr Pro Tyr Tyr Leu Val Gly Arg Arg 
                405                 410                 415     


Pro Ala Gly Gly Asn Ser Ser Gly Gln Ser Asp Asn Cys Ser Ser Ser 
            420                 425                 430         


Ser Glu Ala Asn Gly Thr Gly Leu Glu Leu Leu Gly Gly Pro Ser Leu 
        435                 440                 445             


Arg Ser Ala Tyr Ile Thr Ser Leu Tyr Phe Ala Leu Ser Ser Leu Thr 
    450                 455                 460                 


Ser Val Gly Phe Gly Asn Val Ser Ala Asn Thr Asp Thr Glu Lys Ile 
465                 470                 475                 480 


Phe Ser Ile Cys Thr Met Leu Ile Gly Ala Leu Met His Ala Val Val 
                485                 490                 495     


Phe Gly Asn Val Thr Ala Ile Ile Gln Arg Met Tyr Ala Arg Arg Phe 
            500                 505                 510         


Leu Tyr His Ser Arg Thr Arg Asp Leu Arg Asp Tyr Ile Arg Ile His 
        515                 520                 525             


Arg Ile Pro Lys Pro Leu Lys Gln Arg Met Leu Glu Tyr Phe Gln Ala 
    530                 535                 540                 


Thr Trp Ala Val Asn Asn Gly Ile Asp Thr Thr Glu Leu Leu Gln Ser 
545                 550                 555                 560 


Leu Pro Asp Glu Leu Arg Ala Asp Ile Ala Met His Leu His Lys Glu 
                565                 570                 575     


Val Leu Gln Leu Pro Leu Phe Glu Ala Ala Ser Arg Gly Cys Leu Arg 
            580                 585                 590         


Ala Leu Ser Leu Ala Leu Arg Pro Ala Phe Cys Thr Pro Gly Glu Tyr 
        595                 600                 605             


Leu Ile His Gln Gly Asp Ala Leu Gln Ala Leu Tyr Phe Val Cys Ser 
    610                 615                 620                 


Gly Ser Met Glu Val Leu Lys Gly Gly Thr Val Leu Ala Ile Leu Gly 
625                 630                 635                 640 


Lys Gly Asp Leu Ile Gly Cys Glu Leu Pro Arg Arg Glu Gln Val Val 
                645                 650                 655     


Lys Ala Asn Ala Asp Val Lys Gly Leu Thr Tyr Cys Val Leu Gln Cys 
            660                 665                 670         


Leu Gln Leu Ala Gly Leu His Asp Ser Leu Ala Leu Tyr Pro Glu Phe 
        675                 680                 685             


Ala Pro Arg Phe Ser Arg Gly Leu Arg Gly Glu Leu Ser Tyr Asn Leu 
    690                 695                 700                 


Gly Ala Gly Gly Gly Ser Ala Glu Val Asp Thr Ser Ser Leu Ser Gly 
705                 710                 715                 720 


Asp Asn Thr Leu Met Ser Thr Leu Glu Glu Lys Glu Thr Asp Gly Glu 
                725                 730                 735     


Gln Gly Pro Thr Val Ser Pro Ala Pro Ala Asp Glu Pro Ser Ser Pro 
            740                 745                 750         


Leu Leu Ser Pro Gly Cys Thr Ser Ser Ser Ser Ala Ala Lys Leu Leu 
        755                 760                 765             


Ser Pro Arg Arg Thr Ala Pro Arg Pro Arg Leu Gly Gly Arg Gly Arg 
    770                 775                 780                 


Pro Gly Arg Ala Gly Ala Leu Lys Ala Glu Ala Gly Pro Ser Ala Pro 
785                 790                 795                 800 


Pro Arg Ala Leu Glu Gly Leu Arg Leu Pro Pro Met Pro Trp Asn Val 
                805                 810                 815     


Pro Pro Asp Leu Ser Pro Arg Val Val Asp Gly Ile Glu Asp Gly Cys 
            820                 825                 830         


Gly Ser Asp Gln Pro Lys Phe Ser Phe Arg Val Gly Gln Ser Gly Pro 
        835                 840                 845             


Glu Cys Ser Ser Ser Pro Ser Pro Gly Pro Glu Ser Gly Leu Leu Thr 
    850                 855                 860                 


Val Pro His Gly Pro Ser Glu Ala Arg Asn Thr Asp Thr Leu Asp Lys 
865                 870                 875                 880 


Leu Arg Gln Ala Val Thr Glu Leu Ser Glu Gln Val Leu Gln Met Arg 
                885                 890                 895     


Glu Gly Leu Gln Ser Leu Arg Gln Ala Val Gln Leu Val Leu Ala Pro 
            900                 905                 910         


His Arg Glu Gly Pro Cys Pro Arg Ala Ser Gly Glu Gly Pro Cys Pro 
        915                 920                 925             


Ala Ser Thr Ser Gly Leu Leu Gln Pro Leu Cys Val Asp Thr Gly Ala 
    930                 935                 940                 


Ser Ser Tyr Cys Leu Gln Pro Pro Ala Gly Ser Val Leu Ser Gly Thr 
945                 950                 955                 960 


Trp Pro His Pro Arg Pro Gly Pro Pro Pro Leu Met Ala Pro Trp Pro 
                965                 970                 975     


Trp Gly Pro Pro Ala Ser Gln Ser Ser Pro Trp Pro Arg Ala Thr Ala 
            980                 985                 990         


Phe Trp Thr Ser Thr Ser Asp Ser  Glu Pro Pro Ala Ser  Gly Asp Leu 
        995                 1000                 1005             


Cys Ser  Glu Pro Ser Thr Pro  Ala Ser Pro Pro Pro  Ser Glu Glu 
    1010                 1015                 1020             


Gly Ala  Arg Thr Gly Pro Ala  Glu Pro Val Ser Gln  Ala Glu Ala 
    1025                 1030                 1035             


Thr Ser  Thr Gly Glu Pro Pro  Pro Gly Ser Gly Gly  Leu Ala Leu 
    1040                 1045                 1050             


Pro Trp  Asp Pro His Ser Leu  Glu Met Val Leu Ile  Gly Cys His 
    1055                 1060                 1065             


Gly Ser  Gly Thr Val Gln Trp  Thr Gln Glu Glu Gly  Thr Gly Val 
    1070                 1075                 1080             


<210> 60
<211> 1017
<212> PRT
<213> Homo sapiens

<400> 60
Met Pro Val Met Lys Gly Leu Leu Ala Pro Gln Asn Thr Phe Leu Asp 
1               5                   10                  15      


Thr Ile Ala Thr Arg Phe Asp Gly Thr His Ser Asn Phe Leu Leu Ala 
            20                  25                  30          


Asn Ala Gln Gly Thr Arg Gly Phe Pro Ile Val Tyr Cys Ser Asp Gly 
        35                  40                  45              


Phe Cys Glu Leu Thr Gly Tyr Gly Arg Thr Glu Val Met Gln Lys Thr 
    50                  55                  60                  


Cys Ser Cys Arg Phe Leu Tyr Gly Pro Glu Thr Ser Glu Pro Ala Leu 
65                  70                  75                  80  


Gln Arg Leu His Lys Ala Leu Glu Gly His Gln Glu His Arg Ala Glu 
                85                  90                  95      


Ile Cys Phe Tyr Arg Lys Asp Gly Ser Ala Phe Trp Cys Leu Leu Asp 
            100                 105                 110         


Met Met Pro Ile Lys Asn Glu Met Gly Glu Val Val Leu Phe Leu Phe 
        115                 120                 125             


Ser Phe Lys Asp Ile Thr Gln Ser Gly Ser Pro Gly Leu Gly Pro Gln 
    130                 135                 140                 


Gly Gly Arg Gly Asp Ser Asn His Glu Asn Ser Leu Gly Arg Arg Gly 
145                 150                 155                 160 


Ala Thr Trp Lys Phe Arg Ser Ala Arg Arg Arg Ser Arg Thr Val Leu 
                165                 170                 175     


His Arg Leu Thr Gly His Phe Gly Arg Arg Gly Gln Gly Gly Met Lys 
            180                 185                 190         


Ala Asn Asn Asn Val Phe Glu Pro Lys Pro Ser Val Pro Glu Tyr Lys 
        195                 200                 205             


Val Ala Ser Val Gly Gly Ser Arg Cys Leu Leu Leu His Tyr Ser Val 
    210                 215                 220                 


Ser Lys Ala Ile Trp Asp Gly Leu Ile Leu Leu Ala Thr Phe Tyr Val 
225                 230                 235                 240 


Ala Val Thr Val Pro Tyr Asn Val Cys Phe Ser Gly Asp Asp Asp Thr 
                245                 250                 255     


Pro Ile Thr Ser Arg His Thr Leu Val Ser Asp Ile Ala Val Glu Met 
            260                 265                 270         


Leu Phe Ile Leu Asp Ile Ile Leu Asn Phe Arg Thr Thr Tyr Val Ser 
        275                 280                 285             


Gln Ser Gly Gln Val Ile Ser Ala Pro Arg Ser Ile Gly Leu His Tyr 
    290                 295                 300                 


Leu Ala Thr Trp Phe Phe Ile Asp Leu Ile Ala Ala Leu Pro Phe Asp 
305                 310                 315                 320 


Leu Leu Tyr Ile Phe Asn Ile Thr Val Thr Ser Leu Val His Leu Leu 
                325                 330                 335     


Lys Thr Val Arg Leu Leu Arg Leu Leu Arg Leu Leu Gln Lys Leu Glu 
            340                 345                 350         


Arg Tyr Ser Gln Cys Ser Ala Val Val Leu Thr Leu Leu Met Ser Val 
        355                 360                 365             


Phe Ala Leu Leu Ala His Trp Met Ala Cys Ile Trp Tyr Val Ile Gly 
    370                 375                 380                 


Arg Arg Glu Met Glu Ala Asn Asp Pro Leu Leu Trp Asp Ile Gly Trp 
385                 390                 395                 400 


Leu His Glu Leu Gly Lys Arg Leu Glu Val Pro Tyr Val Asn Gly Ser 
                405                 410                 415     


Val Gly Gly Pro Ser Arg Arg Ser Ala Tyr Ile Ala Ala Leu Tyr Phe 
            420                 425                 430         


Thr Leu Ser Ser Leu Thr Ser Val Gly Phe Gly Asn Val Cys Ala Asn 
        435                 440                 445             


Thr Asp Ala Glu Lys Ile Phe Ser Ile Cys Thr Met Leu Ile Gly Ala 
    450                 455                 460                 


Leu Met His Ala Val Val Phe Gly Asn Val Thr Ala Ile Ile Gln Arg 
465                 470                 475                 480 


Met Tyr Ser Arg Arg Ser Leu Tyr His Ser Arg Met Lys Asp Leu Lys 
                485                 490                 495     


Asp Phe Ile Arg Val His Arg Leu Pro Arg Pro Leu Lys Gln Arg Met 
            500                 505                 510         


Leu Glu Tyr Phe Gln Thr Thr Trp Ala Val Asn Ser Gly Ile Asp Ala 
        515                 520                 525             


Asn Glu Leu Leu Arg Asp Phe Pro Asp Glu Leu Arg Ala Asp Ile Ala 
    530                 535                 540                 


Met His Leu Asn Arg Glu Ile Leu Gln Leu Pro Leu Phe Gly Ala Ala 
545                 550                 555                 560 


Ser Arg Gly Cys Leu Arg Ala Leu Ser Leu His Ile Lys Thr Ser Phe 
                565                 570                 575     


Cys Ala Pro Gly Glu Tyr Leu Leu Arg Arg Gly Asp Ala Leu Gln Ala 
            580                 585                 590         


His Tyr Tyr Val Cys Ser Gly Ser Leu Glu Val Leu Arg Asp Asn Met 
        595                 600                 605             


Val Leu Ala Ile Leu Gly Lys Gly Asp Leu Ile Gly Ala Asp Ile Pro 
    610                 615                 620                 


Glu Pro Gly Gln Glu Pro Gly Leu Gly Ala Asp Pro Asn Phe Val Leu 
625                 630                 635                 640 


Lys Thr Ser Ala Asp Val Lys Ala Leu Thr Tyr Cys Gly Leu Gln Gln 
                645                 650                 655     


Leu Ser Ser Arg Gly Leu Ala Glu Val Leu Arg Leu Tyr Pro Glu Tyr 
            660                 665                 670         


Gly Ala Ala Phe Arg Ala Gly Leu Pro Arg Asp Leu Thr Phe Asn Leu 
        675                 680                 685             


Arg Gln Gly Ser Asp Thr Ser Gly Leu Ser Arg Phe Ser Arg Ser Pro 
    690                 695                 700                 


Arg Leu Ser Gln Pro Arg Ser Glu Ser Leu Gly Ser Ser Ser Asp Lys 
705                 710                 715                 720 


Thr Leu Pro Ser Ile Thr Glu Ala Glu Ser Gly Ala Glu Pro Gly Gly 
                725                 730                 735     


Gly Pro Arg Pro Arg Arg Pro Leu Leu Leu Pro Asn Leu Ser Pro Ala 
            740                 745                 750         


Arg Pro Arg Gly Ser Leu Val Ser Leu Leu Gly Glu Glu Leu Pro Pro 
        755                 760                 765             


Phe Ser Ala Leu Val Ser Ser Pro Ser Leu Ser Pro Ser Leu Ser Pro 
    770                 775                 780                 


Ala Leu Ala Gly Gln Gly His Ser Ala Ser Pro His Gly Pro Pro Arg 
785                 790                 795                 800 


Cys Ser Ala Ala Trp Lys Pro Pro Gln Leu Leu Ile Pro Pro Leu Gly 
                805                 810                 815     


Thr Phe Gly Pro Pro Asp Leu Ser Pro Arg Ile Val Asp Gly Ile Glu 
            820                 825                 830         


Asp Ser Gly Ser Thr Ala Glu Ala Pro Ser Phe Arg Phe Ser Arg Arg 
        835                 840                 845             


Pro Glu Leu Pro Arg Pro Arg Ser Gln Ala Pro Pro Thr Gly Thr Arg 
    850                 855                 860                 


Pro Ser Pro Glu Leu Ala Ser Glu Ala Glu Glu Val Lys Glu Lys Val 
865                 870                 875                 880 


Cys Arg Leu Asn Gln Glu Ile Ser Arg Leu Asn Gln Glu Val Ser Gln 
                885                 890                 895     


Leu Ser Arg Glu Leu Arg His Ile Met Gly Leu Leu Gln Ala Arg Leu 
            900                 905                 910         


Gly Pro Pro Gly His Pro Ala Gly Ser Ala Trp Thr Pro Asp Pro Pro 
        915                 920                 925             


Cys Pro Gln Leu Arg Pro Pro Cys Leu Ser Pro Cys Ala Ser Arg Pro 
    930                 935                 940                 


Pro Pro Ser Leu Gln Asp Thr Thr Leu Ala Glu Val His Cys Pro Ala 
945                 950                 955                 960 


Ser Val Gly Thr Met Glu Thr Gly Thr Ala Leu Leu Asp Leu Arg Pro 
                965                 970                 975     


Ser Ile Leu Pro Pro Tyr Pro Ser Glu Pro Asp Pro Leu Gly Pro Ser 
            980                 985                 990         


Pro Val Pro Glu Ala Ser Pro Pro  Thr Pro Ser Leu Leu  Arg His Ser 
        995                 1000                 1005             


Phe Gln  Ser Arg Ser Asp Thr  Phe His 
    1010                 1015         


<210> 61
<211> 890
<212> PRT
<213> Homo sapiens

<400> 61
Met Glu Gly Gly Gly Lys Pro Asn Ser Ser Ser Asn Ser Arg Asp Asp 
1               5                   10                  15      


Gly Asn Ser Val Phe Pro Ala Lys Ala Ser Ala Thr Gly Ala Gly Pro 
            20                  25                  30          


Ala Ala Ala Glu Lys Arg Leu Gly Thr Pro Pro Gly Gly Gly Gly Ala 
        35                  40                  45              


Gly Ala Lys Glu His Gly Asn Ser Val Cys Phe Lys Val Asp Gly Gly 
    50                  55                  60                  


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Glu Pro Ala Gly Gly 
65                  70                  75                  80  


Phe Glu Asp Ala Glu Gly Pro Arg Arg Gln Tyr Gly Phe Met Gln Arg 
                85                  90                  95      


Gln Phe Thr Ser Met Leu Gln Pro Gly Val Asn Lys Phe Ser Leu Arg 
            100                 105                 110         


Met Phe Gly Ser Gln Lys Ala Val Glu Lys Glu Gln Glu Arg Val Lys 
        115                 120                 125             


Thr Ala Gly Phe Trp Ile Ile His Pro Tyr Ser Asp Phe Arg Phe Tyr 
    130                 135                 140                 


Trp Asp Leu Ile Met Leu Ile Met Met Val Gly Asn Leu Val Ile Ile 
145                 150                 155                 160 


Pro Val Gly Ile Thr Phe Phe Thr Glu Gln Thr Thr Thr Pro Trp Ile 
                165                 170                 175     


Ile Phe Asn Val Ala Ser Asp Thr Val Phe Leu Leu Asp Leu Ile Met 
            180                 185                 190         


Asn Phe Arg Thr Gly Thr Val Asn Glu Asp Ser Ser Glu Ile Ile Leu 
        195                 200                 205             


Asp Pro Lys Val Ile Lys Met Asn Tyr Leu Lys Ser Trp Phe Val Val 
    210                 215                 220                 


Asp Phe Ile Ser Ser Ile Pro Val Asp Tyr Ile Phe Leu Ile Val Glu 
225                 230                 235                 240 


Lys Gly Met Asp Ser Glu Val Tyr Lys Thr Ala Arg Ala Leu Arg Ile 
                245                 250                 255     


Val Arg Phe Thr Lys Ile Leu Ser Leu Leu Arg Leu Leu Arg Leu Ser 
            260                 265                 270         


Arg Leu Ile Arg Tyr Ile His Gln Trp Glu Glu Ile Phe His Met Thr 
        275                 280                 285             


Tyr Asp Leu Ala Ser Ala Val Val Arg Ile Phe Asn Leu Ile Gly Met 
    290                 295                 300                 


Met Leu Leu Leu Cys His Trp Asp Gly Cys Leu Gln Phe Leu Val Pro 
305                 310                 315                 320 


Leu Leu Gln Asp Phe Pro Pro Asp Cys Trp Val Ser Leu Asn Glu Met 
                325                 330                 335     


Val Asn Asp Ser Trp Gly Lys Gln Tyr Ser Tyr Ala Leu Phe Lys Ala 
            340                 345                 350         


Met Ser His Met Leu Cys Ile Gly Tyr Gly Ala Gln Ala Pro Val Ser 
        355                 360                 365             


Met Ser Asp Leu Trp Ile Thr Met Leu Ser Met Ile Val Gly Ala Thr 
    370                 375                 380                 


Cys Tyr Ala Met Phe Val Gly His Ala Thr Ala Leu Ile Gln Ser Leu 
385                 390                 395                 400 


Asp Ser Ser Arg Arg Gln Tyr Gln Glu Lys Tyr Lys Gln Val Glu Gln 
                405                 410                 415     


Tyr Met Ser Phe His Lys Leu Pro Ala Asp Met Arg Gln Lys Ile His 
            420                 425                 430         


Asp Tyr Tyr Glu His Arg Tyr Gln Gly Lys Ile Phe Asp Glu Glu Asn 
        435                 440                 445             


Ile Leu Asn Glu Leu Asn Asp Pro Leu Arg Glu Glu Ile Val Asn Phe 
    450                 455                 460                 


Asn Cys Arg Lys Leu Val Ala Thr Met Pro Leu Phe Ala Asn Ala Asp 
465                 470                 475                 480 


Pro Asn Phe Val Thr Ala Met Leu Ser Lys Leu Arg Phe Glu Val Phe 
                485                 490                 495     


Gln Pro Gly Asp Tyr Ile Ile Arg Glu Gly Ala Val Gly Lys Lys Met 
            500                 505                 510         


Tyr Phe Ile Gln His Gly Val Ala Gly Val Ile Thr Lys Ser Ser Lys 
        515                 520                 525             


Glu Met Lys Leu Thr Asp Gly Ser Tyr Phe Gly Glu Ile Cys Leu Leu 
    530                 535                 540                 


Thr Lys Gly Arg Arg Thr Ala Ser Val Arg Ala Asp Thr Tyr Cys Arg 
545                 550                 555                 560 


Leu Tyr Ser Leu Ser Val Asp Asn Phe Asn Glu Val Leu Glu Glu Tyr 
                565                 570                 575     


Pro Met Met Arg Arg Ala Phe Glu Thr Val Ala Ile Asp Arg Leu Asp 
            580                 585                 590         


Arg Ile Gly Lys Lys Asn Ser Ile Leu Leu Gln Lys Phe Gln Lys Asp 
        595                 600                 605             


Leu Asn Thr Gly Val Phe Asn Asn Gln Glu Asn Glu Ile Leu Lys Gln 
    610                 615                 620                 


Ile Val Lys His Asp Arg Glu Met Val Gln Ala Ile Ala Pro Ile Asn 
625                 630                 635                 640 


Tyr Pro Gln Met Thr Thr Leu Asn Ser Thr Ser Ser Thr Thr Thr Pro 
                645                 650                 655     


Thr Ser Arg Met Arg Thr Gln Ser Pro Pro Val Tyr Thr Ala Thr Ser 
            660                 665                 670         


Leu Ser His Ser Asn Leu His Ser Pro Ser Pro Ser Thr Gln Thr Pro 
        675                 680                 685             


Gln Pro Ser Ala Ile Leu Ser Pro Cys Ser Tyr Thr Thr Ala Val Cys 
    690                 695                 700                 


Ser Pro Pro Val Gln Ser Pro Leu Ala Ala Arg Thr Phe His Tyr Ala 
705                 710                 715                 720 


Ser Pro Thr Ala Ser Gln Leu Ser Leu Met Gln Gln Gln Pro Gln Gln 
                725                 730                 735     


Gln Val Gln Gln Ser Gln Pro Pro Gln Thr Gln Pro Gln Gln Pro Ser 
            740                 745                 750         


Pro Gln Pro Gln Thr Pro Gly Ser Ser Thr Pro Lys Asn Glu Val His 
        755                 760                 765             


Lys Ser Thr Gln Ala Leu His Asn Thr Asn Leu Thr Arg Glu Val Arg 
    770                 775                 780                 


Pro Leu Ser Ala Ser Gln Pro Ser Leu Pro His Glu Val Ser Thr Leu 
785                 790                 795                 800 


Ile Ser Arg Pro His Pro Thr Val Gly Glu Ser Leu Ala Ser Ile Pro 
                805                 810                 815     


Gln Pro Val Thr Ala Val Pro Gly Thr Gly Leu Gln Ala Gly Gly Arg 
            820                 825                 830         


Ser Thr Val Pro Gln Arg Val Thr Leu Phe Arg Gln Met Ser Ser Gly 
        835                 840                 845             


Ala Ile Pro Pro Asn Arg Gly Val Pro Pro Ala Pro Pro Pro Pro Ala 
    850                 855                 860                 


Ala Ala Leu Pro Arg Glu Ser Ser Ser Val Leu Asn Thr Asp Pro Asp 
865                 870                 875                 880 


Ala Glu Lys Pro Arg Phe Ala Ser Asn Leu 
                885                 890 


<210> 62
<211> 889
<212> PRT
<213> Homo sapiens

<400> 62
Met Asp Ala Arg Gly Gly Gly Gly Arg Pro Gly Glu Ser Pro Gly Ala 
1               5                   10                  15      


Thr Pro Ala Pro Gly Pro Pro Pro Pro Pro Pro Pro Ala Pro Pro Gln 
            20                  25                  30          


Gln Gln Pro Pro Pro Pro Pro Pro Pro Ala Pro Pro Pro Gly Pro Gly 
        35                  40                  45              


Pro Ala Pro Pro Gln His Pro Pro Arg Ala Glu Ala Leu Pro Pro Glu 
    50                  55                  60                  


Ala Ala Asp Glu Gly Gly Pro Arg Gly Arg Leu Arg Ser Arg Asp Ser 
65                  70                  75                  80  


Ser Cys Gly Arg Pro Gly Thr Pro Gly Ala Ala Ser Thr Ala Lys Gly 
                85                  90                  95      


Ser Pro Asn Gly Glu Cys Gly Arg Gly Glu Pro Gln Cys Ser Pro Ala 
            100                 105                 110         


Gly Pro Glu Gly Pro Ala Arg Gly Pro Lys Val Ser Phe Ser Cys Arg 
        115                 120                 125             


Gly Ala Ala Ser Gly Pro Ala Pro Gly Pro Gly Pro Ala Glu Glu Ala 
    130                 135                 140                 


Gly Ser Glu Glu Ala Gly Pro Ala Gly Glu Pro Arg Gly Ser Gln Ala 
145                 150                 155                 160 


Ser Phe Met Gln Arg Gln Phe Gly Ala Leu Leu Gln Pro Gly Val Asn 
                165                 170                 175     


Lys Phe Ser Leu Arg Met Phe Gly Ser Gln Lys Ala Val Glu Arg Glu 
            180                 185                 190         


Gln Glu Arg Val Lys Ser Ala Gly Ala Trp Ile Ile His Pro Tyr Ser 
        195                 200                 205             


Asp Phe Arg Phe Tyr Trp Asp Phe Thr Met Leu Leu Phe Met Val Gly 
    210                 215                 220                 


Asn Leu Ile Ile Ile Pro Val Gly Ile Thr Phe Phe Lys Asp Glu Thr 
225                 230                 235                 240 


Thr Ala Pro Trp Ile Val Phe Asn Val Val Ser Asp Thr Phe Phe Leu 
                245                 250                 255     


Met Asp Leu Val Leu Asn Phe Arg Thr Gly Ile Val Ile Glu Asp Asn 
            260                 265                 270         


Thr Glu Ile Ile Leu Asp Pro Glu Lys Ile Lys Lys Lys Tyr Leu Arg 
        275                 280                 285             


Thr Trp Phe Val Val Asp Phe Val Ser Ser Ile Pro Val Asp Tyr Ile 
    290                 295                 300                 


Phe Leu Ile Val Glu Lys Gly Ile Asp Ser Glu Val Tyr Lys Thr Ala 
305                 310                 315                 320 


Arg Ala Leu Arg Ile Val Arg Phe Thr Lys Ile Leu Ser Leu Leu Arg 
                325                 330                 335     


Leu Leu Arg Leu Ser Arg Leu Ile Arg Tyr Ile His Gln Trp Glu Glu 
            340                 345                 350         


Ile Phe His Met Thr Tyr Asp Leu Ala Ser Ala Val Met Arg Ile Cys 
        355                 360                 365             


Asn Leu Ile Ser Met Met Leu Leu Leu Cys His Trp Asp Gly Cys Leu 
    370                 375                 380                 


Gln Phe Leu Val Pro Met Leu Gln Asp Phe Pro Arg Asn Cys Trp Val 
385                 390                 395                 400 


Ser Ile Asn Gly Met Val Asn His Ser Trp Ser Glu Leu Tyr Ser Phe 
                405                 410                 415     


Ala Leu Phe Lys Ala Met Ser His Met Leu Cys Ile Gly Tyr Gly Arg 
            420                 425                 430         


Gln Ala Pro Glu Ser Met Thr Asp Ile Trp Leu Thr Met Leu Ser Met 
        435                 440                 445             


Ile Val Gly Ala Thr Cys Tyr Ala Met Phe Ile Gly His Ala Thr Ala 
    450                 455                 460                 


Leu Ile Gln Ser Leu Asp Ser Ser Arg Arg Gln Tyr Gln Glu Lys Tyr 
465                 470                 475                 480 


Lys Gln Val Glu Gln Tyr Met Ser Phe His Lys Leu Pro Ala Asp Phe 
                485                 490                 495     


Arg Gln Lys Ile His Asp Tyr Tyr Glu His Arg Tyr Gln Gly Lys Met 
            500                 505                 510         


Phe Asp Glu Asp Ser Ile Leu Gly Glu Leu Asn Gly Pro Leu Arg Glu 
        515                 520                 525             


Glu Ile Val Asn Phe Asn Cys Arg Lys Leu Val Ala Ser Met Pro Leu 
    530                 535                 540                 


Phe Ala Asn Ala Asp Pro Asn Phe Val Thr Ala Met Leu Thr Lys Leu 
545                 550                 555                 560 


Lys Phe Glu Val Phe Gln Pro Gly Asp Tyr Ile Ile Arg Glu Gly Thr 
                565                 570                 575     


Ile Gly Lys Lys Met Tyr Phe Ile Gln His Gly Val Val Ser Val Leu 
            580                 585                 590         


Thr Lys Gly Asn Lys Glu Met Lys Leu Ser Asp Gly Ser Tyr Phe Gly 
        595                 600                 605             


Glu Ile Cys Leu Leu Thr Arg Gly Arg Arg Thr Ala Ser Val Arg Ala 
    610                 615                 620                 


Asp Thr Tyr Cys Arg Leu Tyr Ser Leu Ser Val Asp Asn Phe Asn Glu 
625                 630                 635                 640 


Val Leu Glu Glu Tyr Pro Met Met Arg Arg Ala Phe Glu Thr Val Ala 
                645                 650                 655     


Ile Asp Arg Leu Asp Arg Ile Gly Lys Lys Asn Ser Ile Leu Leu His 
            660                 665                 670         


Lys Val Gln His Asp Leu Asn Ser Gly Val Phe Asn Asn Gln Glu Asn 
        675                 680                 685             


Ala Ile Ile Gln Glu Ile Val Lys Tyr Asp Arg Glu Met Val Gln Gln 
    690                 695                 700                 


Ala Glu Leu Gly Gln Arg Val Gly Leu Phe Pro Pro Pro Pro Pro Pro 
705                 710                 715                 720 


Pro Gln Val Thr Ser Ala Ile Ala Thr Leu Gln Gln Ala Ala Ala Met 
                725                 730                 735     


Ser Phe Cys Pro Gln Val Ala Arg Pro Leu Val Gly Pro Leu Ala Leu 
            740                 745                 750         


Gly Ser Pro Arg Leu Val Arg Arg Pro Pro Pro Gly Pro Ala Pro Ala 
        755                 760                 765             


Ala Ala Ser Pro Gly Pro Pro Pro Pro Ala Ser Pro Pro Gly Ala Pro 
    770                 775                 780                 


Ala Ser Pro Arg Ala Pro Arg Thr Ser Pro Tyr Gly Gly Leu Pro Ala 
785                 790                 795                 800 


Ala Pro Leu Ala Gly Pro Ala Leu Pro Ala Arg Arg Leu Ser Arg Ala 
                805                 810                 815     


Ser Arg Pro Leu Ser Ala Ser Gln Pro Ser Leu Pro His Gly Ala Pro 
            820                 825                 830         


Gly Pro Ala Ala Ser Thr Arg Pro Ala Ser Ser Ser Thr Pro Arg Leu 
        835                 840                 845             


Gly Pro Thr Pro Ala Ala Arg Ala Ala Ala Pro Ser Pro Asp Arg Arg 
    850                 855                 860                 


Asp Ser Ala Ser Pro Gly Ala Ala Gly Gly Leu Asp Pro Gln Asp Ser 
865                 870                 875                 880 


Ala Arg Ser Arg Leu Ser Ser Asn Leu 
                885                 


<210> 63
<211> 774
<212> PRT
<213> Homo sapiens

<400> 63
Met Glu Ala Glu Gln Arg Pro Ala Ala Gly Ala Ser Glu Gly Ala Thr 
1               5                   10                  15      


Pro Gly Leu Glu Ala Val Pro Pro Val Ala Pro Pro Pro Ala Thr Ala 
            20                  25                  30          


Ala Ser Gly Pro Ile Pro Lys Ser Gly Pro Glu Pro Lys Arg Arg His 
        35                  40                  45              


Leu Gly Thr Leu Leu Gln Pro Thr Val Asn Lys Phe Ser Leu Arg Val 
    50                  55                  60                  


Phe Gly Ser His Lys Ala Val Glu Ile Glu Gln Glu Arg Val Lys Ser 
65                  70                  75                  80  


Ala Gly Ala Trp Ile Ile His Pro Tyr Ser Asp Phe Arg Phe Tyr Trp 
                85                  90                  95      


Asp Leu Ile Met Leu Leu Leu Met Val Gly Asn Leu Ile Val Leu Pro 
            100                 105                 110         


Val Gly Ile Thr Phe Phe Lys Glu Glu Asn Ser Pro Pro Trp Ile Val 
        115                 120                 125             


Phe Asn Val Leu Ser Asp Thr Phe Phe Leu Leu Asp Leu Val Leu Asn 
    130                 135                 140                 


Phe Arg Thr Gly Ile Val Val Glu Glu Gly Ala Glu Ile Leu Leu Ala 
145                 150                 155                 160 


Pro Arg Ala Ile Arg Thr Arg Tyr Leu Arg Thr Trp Phe Leu Val Asp 
                165                 170                 175     


Leu Ile Ser Ser Ile Pro Val Asp Tyr Ile Phe Leu Val Val Glu Leu 
            180                 185                 190         


Glu Pro Arg Leu Asp Ala Glu Val Tyr Lys Thr Ala Arg Ala Leu Arg 
        195                 200                 205             


Ile Val Arg Phe Thr Lys Ile Leu Ser Leu Leu Arg Leu Leu Arg Leu 
    210                 215                 220                 


Ser Arg Leu Ile Arg Tyr Ile His Gln Trp Glu Glu Ile Phe His Met 
225                 230                 235                 240 


Thr Tyr Asp Leu Ala Ser Ala Val Val Arg Ile Phe Asn Leu Ile Gly 
                245                 250                 255     


Met Met Leu Leu Leu Cys His Trp Asp Gly Cys Leu Gln Phe Leu Val 
            260                 265                 270         


Pro Met Leu Gln Asp Phe Pro Pro Asp Cys Trp Val Ser Ile Asn His 
        275                 280                 285             


Met Val Asn His Ser Trp Gly Arg Gln Tyr Ser His Ala Leu Phe Lys 
    290                 295                 300                 


Ala Met Ser His Met Leu Cys Ile Gly Tyr Gly Gln Gln Ala Pro Val 
305                 310                 315                 320 


Gly Met Pro Asp Val Trp Leu Thr Met Leu Ser Met Ile Val Gly Ala 
                325                 330                 335     


Thr Cys Tyr Ala Met Phe Ile Gly His Ala Thr Ala Leu Ile Gln Ser 
            340                 345                 350         


Leu Asp Ser Ser Arg Arg Gln Tyr Gln Glu Lys Tyr Lys Gln Val Glu 
        355                 360                 365             


Gln Tyr Met Ser Phe His Lys Leu Pro Ala Asp Thr Arg Gln Arg Ile 
    370                 375                 380                 


His Glu Tyr Tyr Glu His Arg Tyr Gln Gly Lys Met Phe Asp Glu Glu 
385                 390                 395                 400 


Ser Ile Leu Gly Glu Leu Ser Glu Pro Leu Arg Glu Glu Ile Ile Asn 
                405                 410                 415     


Phe Thr Cys Arg Gly Leu Val Ala His Met Pro Leu Phe Ala His Ala 
            420                 425                 430         


Asp Pro Ser Phe Val Thr Ala Val Leu Thr Lys Leu Arg Phe Glu Val 
        435                 440                 445             


Phe Gln Pro Gly Asp Leu Val Val Arg Glu Gly Ser Val Gly Arg Lys 
    450                 455                 460                 


Met Tyr Phe Ile Gln His Gly Leu Leu Ser Val Leu Ala Arg Gly Ala 
465                 470                 475                 480 


Arg Asp Thr Arg Leu Thr Asp Gly Ser Tyr Phe Gly Glu Ile Cys Leu 
                485                 490                 495     


Leu Thr Arg Gly Arg Arg Thr Ala Ser Val Arg Ala Asp Thr Tyr Cys 
            500                 505                 510         


Arg Leu Tyr Ser Leu Ser Val Asp His Phe Asn Ala Val Leu Glu Glu 
        515                 520                 525             


Phe Pro Met Met Arg Arg Ala Phe Glu Thr Val Ala Met Asp Arg Leu 
    530                 535                 540                 


Leu Arg Ile Gly Lys Lys Asn Ser Ile Leu Gln Arg Lys Arg Ser Glu 
545                 550                 555                 560 


Pro Ser Pro Gly Ser Ser Gly Gly Ile Met Glu Gln His Leu Val Gln 
                565                 570                 575     


His Asp Arg Asp Met Ala Arg Gly Val Arg Gly Arg Ala Pro Ser Thr 
            580                 585                 590         


Gly Ala Gln Leu Ser Gly Lys Pro Val Leu Trp Glu Pro Leu Val His 
        595                 600                 605             


Ala Pro Leu Gln Ala Ala Ala Val Thr Ser Asn Val Ala Ile Ala Leu 
    610                 615                 620                 


Thr His Gln Arg Gly Pro Leu Pro Leu Ser Pro Asp Ser Pro Ala Thr 
625                 630                 635                 640 


Leu Leu Ala Arg Ser Ala Trp Arg Ser Ala Gly Ser Pro Ala Ser Pro 
                645                 650                 655     


Leu Val Pro Val Arg Ala Gly Pro Trp Ala Ser Thr Ser Arg Leu Pro 
            660                 665                 670         


Ala Pro Pro Ala Arg Thr Leu His Ala Ser Leu Ser Arg Ala Gly Arg 
        675                 680                 685             


Ser Gln Val Ser Leu Leu Gly Pro Pro Pro Gly Gly Gly Gly Arg Arg 
    690                 695                 700                 


Leu Gly Pro Arg Gly Arg Pro Leu Ser Ala Ser Gln Pro Ser Leu Pro 
705                 710                 715                 720 


Gln Arg Ala Thr Gly Asp Gly Ser Pro Gly Arg Lys Gly Ser Gly Ser 
                725                 730                 735     


Glu Arg Leu Pro Pro Ser Gly Leu Leu Ala Lys Pro Pro Arg Thr Ala 
            740                 745                 750         


Gln Pro Pro Arg Pro Pro Val Pro Glu Pro Ala Thr Pro Arg Gly Leu 
        755                 760                 765             


Gln Leu Ser Ala Asn Met 
    770                 


<210> 64
<211> 1203
<212> PRT
<213> Homo sapiens

<400> 64
Met Asp Lys Leu Pro Pro Ser Met Arg Lys Arg Leu Tyr Ser Leu Pro 
1               5                   10                  15      


Gln Gln Val Gly Ala Lys Ala Trp Ile Met Asp Glu Glu Glu Asp Ala 
            20                  25                  30          


Glu Glu Glu Gly Ala Gly Gly Arg Gln Asp Pro Ser Arg Arg Ser Ile 
        35                  40                  45              


Arg Leu Arg Pro Leu Pro Ser Pro Ser Pro Ser Ala Ala Ala Gly Gly 
    50                  55                  60                  


Thr Glu Ser Arg Ser Ser Ala Leu Gly Ala Ala Asp Ser Glu Gly Pro 
65                  70                  75                  80  


Ala Arg Gly Ala Gly Lys Ser Ser Thr Asn Gly Asp Cys Arg Arg Phe 
                85                  90                  95      


Arg Gly Ser Leu Ala Ser Leu Gly Ser Arg Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Thr Gly Ser Gly Ser Ser His Gly His Leu His Asp Ser Ala Glu Glu 
        115                 120                 125             


Arg Arg Leu Ile Ala Glu Gly Asp Ala Ser Pro Gly Glu Asp Arg Thr 
    130                 135                 140                 


Pro Pro Gly Leu Ala Ala Glu Pro Glu Arg Pro Gly Ala Ser Ala Gln 
145                 150                 155                 160 


Pro Ala Ala Ser Pro Pro Pro Pro Gln Gln Pro Pro Gln Pro Ala Ser 
                165                 170                 175     


Ala Ser Cys Glu Gln Pro Ser Val Asp Thr Ala Ile Lys Val Glu Gly 
            180                 185                 190         


Gly Ala Ala Ala Gly Asp Gln Ile Leu Pro Glu Ala Glu Val Arg Leu 
        195                 200                 205             


Gly Gln Ala Gly Phe Met Gln Arg Gln Phe Gly Ala Met Leu Gln Pro 
    210                 215                 220                 


Gly Val Asn Lys Phe Ser Leu Arg Met Phe Gly Ser Gln Lys Ala Val 
225                 230                 235                 240 


Glu Arg Glu Gln Glu Arg Val Lys Ser Ala Gly Phe Trp Ile Ile His 
                245                 250                 255     


Pro Tyr Ser Asp Phe Arg Phe Tyr Trp Asp Leu Thr Met Leu Leu Leu 
            260                 265                 270         


Met Val Gly Asn Leu Ile Ile Ile Pro Val Gly Ile Thr Phe Phe Lys 
        275                 280                 285             


Asp Glu Asn Thr Thr Pro Trp Ile Val Phe Asn Val Val Ser Asp Thr 
    290                 295                 300                 


Phe Phe Leu Ile Asp Leu Val Leu Asn Phe Arg Thr Gly Ile Val Val 
305                 310                 315                 320 


Glu Asp Asn Thr Glu Ile Ile Leu Asp Pro Gln Arg Ile Lys Met Lys 
                325                 330                 335     


Tyr Leu Lys Ser Trp Phe Met Val Asp Phe Ile Ser Ser Ile Pro Val 
            340                 345                 350         


Asp Tyr Ile Phe Leu Ile Val Glu Thr Arg Ile Asp Ser Glu Val Tyr 
        355                 360                 365             


Lys Thr Ala Arg Ala Leu Arg Ile Val Arg Phe Thr Lys Ile Leu Ser 
    370                 375                 380                 


Leu Leu Arg Leu Leu Arg Leu Ser Arg Leu Ile Arg Tyr Ile His Gln 
385                 390                 395                 400 


Trp Glu Glu Ile Phe His Met Thr Tyr Asp Leu Ala Ser Ala Val Val 
                405                 410                 415     


Arg Ile Val Asn Leu Ile Gly Met Met Leu Leu Leu Cys His Trp Asp 
            420                 425                 430         


Gly Cys Leu Gln Phe Leu Val Pro Met Leu Gln Asp Phe Pro Asp Asp 
        435                 440                 445             


Cys Trp Val Ser Ile Asn Asn Met Val Asn Asn Ser Trp Gly Lys Gln 
    450                 455                 460                 


Tyr Ser Tyr Ala Leu Phe Lys Ala Met Ser His Met Leu Cys Ile Gly 
465                 470                 475                 480 


Tyr Gly Arg Gln Ala Pro Val Gly Met Ser Asp Val Trp Leu Thr Met 
                485                 490                 495     


Leu Ser Met Ile Val Gly Ala Thr Cys Tyr Ala Met Phe Ile Gly His 
            500                 505                 510         


Ala Thr Ala Leu Ile Gln Ser Leu Asp Ser Ser Arg Arg Gln Tyr Gln 
        515                 520                 525             


Glu Lys Tyr Lys Gln Val Glu Gln Tyr Met Ser Phe His Lys Leu Pro 
    530                 535                 540                 


Pro Asp Thr Arg Gln Arg Ile His Asp Tyr Tyr Glu His Arg Tyr Gln 
545                 550                 555                 560 


Gly Lys Met Phe Asp Glu Glu Ser Ile Leu Gly Glu Leu Ser Glu Pro 
                565                 570                 575     


Leu Arg Glu Glu Ile Ile Asn Phe Asn Cys Arg Lys Leu Val Ala Ser 
            580                 585                 590         


Met Pro Leu Phe Ala Asn Ala Asp Pro Asn Phe Val Thr Ser Met Leu 
        595                 600                 605             


Thr Lys Leu Arg Phe Glu Val Phe Gln Pro Gly Asp Tyr Ile Ile Arg 
    610                 615                 620                 


Glu Gly Thr Ile Gly Lys Lys Met Tyr Phe Ile Gln His Gly Val Val 
625                 630                 635                 640 


Ser Val Leu Thr Lys Gly Asn Lys Glu Thr Lys Leu Ala Asp Gly Ser 
                645                 650                 655     


Tyr Phe Gly Glu Ile Cys Leu Leu Thr Arg Gly Arg Arg Thr Ala Ser 
            660                 665                 670         


Val Arg Ala Asp Thr Tyr Cys Arg Leu Tyr Ser Leu Ser Val Asp Asn 
        675                 680                 685             


Phe Asn Glu Val Leu Glu Glu Tyr Pro Met Met Arg Arg Ala Phe Glu 
    690                 695                 700                 


Thr Val Ala Leu Asp Arg Leu Asp Arg Ile Gly Lys Lys Asn Ser Ile 
705                 710                 715                 720 


Leu Leu His Lys Val Gln His Asp Leu Asn Ser Gly Val Phe Asn Tyr 
                725                 730                 735     


Gln Glu Asn Glu Ile Ile Gln Gln Ile Val Gln His Asp Arg Glu Met 
            740                 745                 750         


Ala His Cys Ala His Arg Val Gln Ala Ala Ala Ser Ala Thr Pro Thr 
        755                 760                 765             


Pro Thr Pro Val Ile Trp Thr Pro Leu Ile Gln Ala Pro Leu Gln Ala 
    770                 775                 780                 


Ala Ala Ala Thr Thr Ser Val Ala Ile Ala Leu Thr His His Pro Arg 
785                 790                 795                 800 


Leu Pro Ala Ala Ile Phe Arg Pro Pro Pro Gly Ser Gly Leu Gly Asn 
                805                 810                 815     


Leu Gly Ala Gly Gln Thr Pro Arg His Leu Lys Arg Leu Gln Ser Leu 
            820                 825                 830         


Ile Pro Ser Ala Leu Gly Ser Ala Ser Pro Ala Ser Ser Pro Ser Gln 
        835                 840                 845             


Val Asp Thr Pro Ser Ser Ser Ser Phe His Ile Gln Gln Leu Ala Gly 
    850                 855                 860                 


Phe Ser Ala Pro Ala Gly Leu Ser Pro Leu Leu Pro Ser Ser Ser Ser 
865                 870                 875                 880 


Ser Pro Pro Pro Gly Ala Cys Gly Ser Pro Ser Ala Pro Thr Pro Ser 
                885                 890                 895     


Ala Gly Val Ala Ala Thr Thr Ile Ala Gly Phe Gly His Phe His Lys 
            900                 905                 910         


Ala Leu Gly Gly Ser Leu Ser Ser Ser Asp Ser Pro Leu Leu Thr Pro 
        915                 920                 925             


Leu Gln Pro Gly Ala Arg Ser Pro Gln Ala Ala Gln Pro Ser Pro Ala 
    930                 935                 940                 


Pro Pro Gly Ala Arg Gly Gly Leu Gly Leu Pro Glu His Phe Leu Pro 
945                 950                 955                 960 


Pro Pro Pro Ser Ser Arg Ser Pro Ser Ser Ser Pro Gly Gln Leu Gly 
                965                 970                 975     


Gln Pro Pro Gly Glu Leu Ser Leu Gly Leu Ala Thr Gly Pro Leu Ser 
            980                 985                 990         


Thr Pro Glu Thr Pro Pro Arg Gln  Pro Glu Pro Pro Ser  Leu Val Ala 
        995                 1000                 1005             


Gly Ala  Ser Gly Gly Ala Ser  Pro Val Gly Phe Thr  Pro Arg Gly 
    1010                 1015                 1020             


Gly Leu  Ser Pro Pro Gly His  Ser Pro Gly Pro Pro  Arg Thr Phe 
    1025                 1030                 1035             


Pro Ser  Ala Pro Pro Arg Ala  Ser Gly Ser His Gly  Ser Leu Leu 
    1040                 1045                 1050             


Leu Pro  Pro Ala Ser Ser Pro  Pro Pro Pro Gln Val  Pro Gln Arg 
    1055                 1060                 1065             


Arg Gly  Thr Pro Pro Leu Thr  Pro Gly Arg Leu Thr  Gln Asp Leu 
    1070                 1075                 1080             


Lys Leu  Ile Ser Ala Ser Gln  Pro Ala Leu Pro Gln  Asp Gly Ala 
    1085                 1090                 1095             


Gln Thr  Leu Arg Arg Ala Ser  Pro His Ser Ser Gly  Glu Ser Met 
    1100                 1105                 1110             


Ala Ala  Phe Pro Leu Phe Pro  Arg Ala Gly Gly Gly  Ser Gly Gly 
    1115                 1120                 1125             


Ser Gly  Ser Ser Gly Gly Leu  Gly Pro Pro Gly Arg  Pro Tyr Gly 
    1130                 1135                 1140             


Ala Ile  Pro Gly Gln His Val  Thr Leu Pro Arg Lys  Thr Ser Ser 
    1145                 1150                 1155             


Gly Ser  Leu Pro Pro Pro Leu  Ser Leu Phe Gly Ala  Arg Ala Thr 
    1160                 1165                 1170             


Ser Ser  Gly Gly Pro Pro Leu  Thr Ala Gly Pro Gln  Arg Glu Pro 
    1175                 1180                 1185             


Gly Ala  Arg Pro Glu Pro Val  Arg Ser Lys Leu Pro  Ser Asn Leu 
    1190                 1195                 1200             


<210> 65
<211> 780
<212> PRT
<213> Homo sapiens

<400> 65
Met Asp Gln Asn Ser Val Pro Glu Lys Ala Gln Asn Glu Ala Asp Thr 
1               5                   10                  15      


Asn Asn Ala Asp Arg Phe Phe Arg Ser His Ser Ser Pro Pro His His 
            20                  25                  30          


Arg Pro Gly His Ser Arg Ala Leu His His Tyr Glu Leu His His His 
        35                  40                  45              


Gly Val Pro His Gln Arg Gly Glu Ser His His Pro Pro Glu Phe Gln 
    50                  55                  60                  


Asp Phe His Asp Gln Ala Leu Ser Ser His Val His Gln Ser His His 
65                  70                  75                  80  


His Ser Glu Ala Arg Asn His Gly Arg Ala His Gly Pro Thr Gly Phe 
                85                  90                  95      


Gly Leu Ala Pro Ser Gln Gly Ala Val Pro Ser His Arg Ser Tyr Gly 
            100                 105                 110         


Glu Asp Tyr His Asp Glu Leu Gln Arg Asp Gly Arg Arg His His Asp 
        115                 120                 125             


Gly Ser Gln Tyr Gly Gly Phe His Gln Gln Ser Asp Ser His Tyr His 
    130                 135                 140                 


Arg Gly Ser His His Gly Arg Pro Gln Tyr Leu Gly Glu Asn Leu Ser 
145                 150                 155                 160 


His Tyr Ser Ser Gly Val Pro His His Gly Glu Ala Ser His His Gly 
                165                 170                 175     


Gly Ser Tyr Leu Pro His Gly Pro Asn Pro Tyr Ser Glu Ser Phe His 
            180                 185                 190         


His Ser Glu Ala Ser His Leu Ser Gly Leu Gln His Asp Glu Ser Gln 
        195                 200                 205             


His His Gln Val Pro His Arg Gly Trp Pro His His His Gln Val His 
    210                 215                 220                 


His His Gly Arg Ser Arg His His Glu Ala His Gln His Gly Lys Ser 
225                 230                 235                 240 


Pro His His Gly Glu Thr Ile Ser Pro His Ser Ser Val Gly Ser Tyr 
                245                 250                 255     


Gln Arg Gly Ile Ser Asp Tyr His Ser Glu Tyr His Gln Gly Asp His 
            260                 265                 270         


His Pro Ser Glu Tyr His His Gly Asp His Pro His His Thr Gln His 
        275                 280                 285             


His Tyr His Gln Thr His Arg His Arg Asp Tyr His Gln His Gln Asp 
    290                 295                 300                 


His His Gly Ala Tyr His Ser Ser Tyr Leu His Gly Asp Tyr Val Gln 
305                 310                 315                 320 


Ser Thr Ser Gln Leu Ser Ile Pro His Thr Ser Arg Ser Leu Ile His 
                325                 330                 335     


Asp Ala Pro Gly Pro Ala Ala Ser Arg Thr Gly Val Phe Pro Tyr His 
            340                 345                 350         


Val Ala His Pro Arg Gly Ser Ala His Ser Met Thr Arg Ser Ser Ser 
        355                 360                 365             


Thr Ile Arg Ser Arg Val Thr Gln Met Ser Lys Lys Val His Thr Gln 
    370                 375                 380                 


Asp Ile Ser Thr Lys His Ser Glu Asp Trp Gly Lys Glu Glu Gly Gln 
385                 390                 395                 400 


Phe Gln Lys Arg Lys Thr Gly Arg Leu Gln Arg Thr Arg Lys Lys Gly 
                405                 410                 415     


His Ser Thr Asn Leu Phe Gln Trp Leu Trp Glu Lys Leu Thr Phe Leu 
            420                 425                 430         


Ile Gln Gly Phe Arg Glu Met Ile Arg Asn Leu Thr Gln Ser Leu Ala 
        435                 440                 445             


Phe Glu Thr Phe Ile Phe Phe Val Val Cys Leu Asn Thr Val Met Leu 
    450                 455                 460                 


Val Ala Gln Thr Phe Ala Glu Val Glu Ile Arg Gly Glu Trp Tyr Phe 
465                 470                 475                 480 


Met Ala Leu Asp Ser Ile Phe Phe Cys Ile Tyr Val Val Glu Ala Leu 
                485                 490                 495     


Leu Lys Ile Ile Ala Leu Gly Leu Ser Tyr Phe Phe Asp Phe Trp Asn 
            500                 505                 510         


Asn Leu Asp Phe Phe Ile Met Ala Met Ala Val Leu Asp Phe Leu Leu 
        515                 520                 525             


Met Gln Thr His Ser Phe Ala Ile Tyr His Gln Ser Leu Phe Arg Ile 
    530                 535                 540                 


Leu Lys Val Phe Lys Ser Leu Arg Ala Leu Arg Ala Ile Arg Val Leu 
545                 550                 555                 560 


Arg Arg Leu Ser Phe Leu Thr Ser Val Gln Glu Val Thr Gly Thr Leu 
                565                 570                 575     


Gly Gln Ser Leu Pro Ser Ile Ala Ala Ile Leu Ile Leu Met Phe Thr 
            580                 585                 590         


Cys Leu Phe Leu Phe Ser Ala Val Leu Arg Ala Leu Phe Arg Lys Ser 
        595                 600                 605             


Asp Pro Lys Arg Phe Gln Asn Ile Phe Thr Thr Ile Phe Thr Leu Phe 
    610                 615                 620                 


Thr Leu Leu Thr Leu Asp Asp Trp Ser Leu Ile Tyr Met Asp Ser Arg 
625                 630                 635                 640 


Ala Gln Gly Ala Trp Tyr Ile Ile Pro Ile Leu Ile Ile Tyr Ile Ile 
                645                 650                 655     


Ile Gln Tyr Phe Ile Phe Leu Asn Leu Val Ile Thr Val Leu Val Asp 
            660                 665                 670         


Ser Phe Gln Thr Ala Leu Phe Lys Gly Leu Glu Lys Ala Lys Gln Glu 
        675                 680                 685             


Arg Ala Ala Arg Ile Gln Glu Lys Leu Leu Glu Asp Ser Leu Thr Glu 
    690                 695                 700                 


Leu Arg Ala Ala Glu Pro Lys Glu Val Ala Ser Glu Gly Thr Met Leu 
705                 710                 715                 720 


Lys Arg Leu Ile Glu Lys Lys Phe Gly Thr Met Thr Glu Lys Gln Gln 
                725                 730                 735     


Glu Leu Leu Phe His Tyr Leu Gln Leu Val Ala Ser Val Glu Gln Glu 
            740                 745                 750         


Gln Gln Lys Phe Arg Ser Gln Ala Ala Val Ile Asp Glu Ile Val Asp 
        755                 760                 765             


Thr Thr Phe Glu Ala Gly Glu Glu Asp Phe Arg Asn 
    770                 775                 780 


<210> 66
<211> 528
<212> PRT
<213> Homo sapiens

<400> 66
Met Ala Ala Tyr Gln Gln Glu Glu Gln Met Gln Leu Pro Arg Ala Asp 
1               5                   10                  15      


Ala Ile Arg Ser Arg Leu Ile Asp Thr Phe Ser Leu Ile Glu His Leu 
            20                  25                  30          


Gln Gly Leu Ser Gln Ala Val Pro Arg His Thr Ile Arg Glu Leu Leu 
        35                  40                  45              


Asp Pro Ser Arg Gln Lys Lys Leu Val Leu Gly Asp Gln His Gln Leu 
    50                  55                  60                  


Val Arg Phe Ser Ile Lys Pro Gln Arg Ile Glu Gln Ile Ser His Ala 
65                  70                  75                  80  


Gln Arg Leu Leu Ser Arg Leu His Val Arg Cys Ser Gln Arg Pro Pro 
                85                  90                  95      


Leu Ser Leu Trp Ala Gly Trp Val Leu Glu Cys Pro Leu Phe Lys Asn 
            100                 105                 110         


Phe Ile Ile Phe Leu Val Phe Leu Asn Thr Ile Ile Leu Met Val Glu 
        115                 120                 125             


Ile Glu Leu Leu Glu Ser Thr Asn Thr Lys Leu Trp Pro Leu Lys Leu 
    130                 135                 140                 


Thr Leu Glu Val Ala Ala Trp Phe Ile Leu Leu Ile Phe Ile Leu Glu 
145                 150                 155                 160 


Ile Leu Leu Lys Trp Leu Ser Asn Phe Ser Val Phe Trp Lys Ser Ala 
                165                 170                 175     


Trp Asn Val Phe Asp Phe Val Val Thr Met Leu Ser Leu Leu Pro Glu 
            180                 185                 190         


Val Val Val Leu Val Gly Val Thr Gly Gln Ser Val Trp Leu Gln Leu 
        195                 200                 205             


Leu Arg Ile Cys Arg Val Leu Arg Ser Leu Lys Leu Leu Ala Gln Phe 
    210                 215                 220                 


Arg Gln Ile Gln Ile Ile Ile Leu Val Leu Val Arg Ala Leu Lys Ser 
225                 230                 235                 240 


Met Thr Phe Leu Leu Met Leu Leu Leu Ile Phe Phe Tyr Ile Phe Ala 
                245                 250                 255     


Val Thr Gly Val Tyr Val Phe Ser Glu Tyr Thr Arg Ser Pro Arg Gln 
            260                 265                 270         


Asp Leu Glu Tyr His Val Phe Phe Ser Asp Leu Pro Asn Ser Leu Val 
        275                 280                 285             


Thr Val Phe Ile Leu Phe Thr Leu Asp His Trp Tyr Ala Leu Leu Gln 
    290                 295                 300                 


Asp Val Trp Lys Val Pro Glu Val Ser Arg Ile Phe Ser Ser Ile Tyr 
305                 310                 315                 320 


Phe Ile Leu Trp Leu Leu Leu Gly Ser Ile Ile Phe Arg Ser Ile Ile 
                325                 330                 335     


Val Ala Met Met Val Thr Asn Phe Gln Asn Ile Arg Lys Glu Leu Asn 
            340                 345                 350         


Glu Glu Met Ala Arg Arg Glu Val Gln Leu Lys Ala Asp Met Phe Lys 
        355                 360                 365             


Arg Gln Ile Ile Gln Arg Arg Lys Asn Met Ser His Glu Ala Leu Thr 
    370                 375                 380                 


Ser Ser His Ser Lys Ile Glu Asp Arg Gly Ala Ser Gln Gln Arg Glu 
385                 390                 395                 400 


Ser Leu Asp Leu Ser Glu Val Ser Glu Val Glu Ser Asn Tyr Gly Ala 
                405                 410                 415     


Thr Glu Glu Asp Leu Ile Thr Ser Ala Ser Lys Thr Glu Glu Thr Leu 
            420                 425                 430         


Ser Lys Lys Arg Glu Tyr Gln Ser Ser Ser Cys Val Ser Ser Thr Ser 
        435                 440                 445             


Ser Ser Tyr Ser Ser Ser Ser Glu Ser Arg Phe Ser Glu Ser Ile Gly 
    450                 455                 460                 


Arg Leu Asp Trp Glu Thr Leu Val His Glu Asn Leu Pro Gly Leu Met 
465                 470                 475                 480 


Glu Met Asp Gln Asp Asp Arg Val Trp Pro Arg Asp Ser Leu Phe Arg 
                485                 490                 495     


Tyr Phe Glu Leu Leu Glu Lys Leu Gln Tyr Asn Leu Glu Glu Arg Lys 
            500                 505                 510         


Lys Leu Gln Glu Phe Ala Val Gln Ala Leu Met Asn Leu Glu Asp Lys 
        515                 520                 525             


<210> 67
<211> 398
<212> PRT
<213> Homo sapiens

<400> 67
Met Ser Gln His Arg His Gln Arg His Ser Arg Val Ile Ser Ser Ser 
1               5                   10                  15      


Pro Val Asp Thr Thr Ser Val Gly Phe Cys Pro Thr Phe Lys Lys Phe 
            20                  25                  30          


Lys Arg Asn Asp Asp Glu Cys Arg Ala Phe Val Lys Arg Val Ile Met 
        35                  40                  45              


Ser Arg Phe Phe Lys Ile Ile Met Ile Ser Thr Val Thr Ser Asn Ala 
    50                  55                  60                  


Phe Phe Met Ala Leu Trp Thr Ser Tyr Asp Ile Arg Tyr Arg Leu Phe 
65                  70                  75                  80  


Arg Leu Leu Glu Phe Ser Glu Ile Phe Phe Val Ser Ile Cys Thr Ser 
                85                  90                  95      


Glu Leu Ser Met Lys Val Tyr Val Asp Pro Ile Asn Tyr Trp Lys Asn 
            100                 105                 110         


Gly Tyr Asn Leu Leu Asp Val Ile Ile Ile Ile Val Met Phe Leu Pro 
        115                 120                 125             


Tyr Ala Leu Arg Gln Leu Met Gly Lys Gln Phe Thr Tyr Leu Tyr Ile 
    130                 135                 140                 


Ala Asp Gly Met Gln Ser Leu Arg Ile Leu Lys Leu Ile Gly Tyr Ser 
145                 150                 155                 160 


Gln Gly Ile Arg Thr Leu Ile Thr Ala Val Gly Gln Thr Val Tyr Thr 
                165                 170                 175     


Val Ala Ser Val Leu Leu Leu Leu Phe Leu Leu Met Tyr Ile Phe Ala 
            180                 185                 190         


Ile Leu Gly Phe Cys Leu Phe Gly Ser Pro Asp Asn Gly Asp His Asp 
        195                 200                 205             


Asn Trp Gly Asn Leu Ala Ala Ala Phe Phe Thr Leu Phe Ser Leu Ala 
    210                 215                 220                 


Thr Val Asp Gly Trp Thr Asp Leu Gln Lys Gln Leu Asp Asn Arg Glu 
225                 230                 235                 240 


Phe Ala Leu Ser Arg Ala Phe Thr Ile Ile Phe Ile Leu Leu Ala Ser 
                245                 250                 255     


Phe Ile Phe Leu Asn Met Phe Val Gly Val Met Ile Met His Thr Glu 
            260                 265                 270         


Asp Ser Ile Arg Lys Phe Glu Arg Glu Leu Met Leu Glu Gln Gln Glu 
        275                 280                 285             


Met Leu Met Gly Glu Lys Gln Val Ile Leu Gln Arg Gln Gln Glu Glu 
    290                 295                 300                 


Ile Ser Arg Leu Met His Ile Gln Lys Asn Ala Asp Cys Thr Ser Phe 
305                 310                 315                 320 


Ser Glu Leu Val Glu Asn Phe Lys Lys Thr Leu Ser His Thr Asp Pro 
                325                 330                 335     


Met Val Leu Asp Asp Phe Gly Thr Ser Leu Pro Phe Ile Asp Ile Tyr 
            340                 345                 350         


Phe Ser Thr Leu Asp Tyr Gln Asp Thr Thr Val His Lys Leu Gln Glu 
        355                 360                 365             


Leu Tyr Tyr Glu Ile Val His Val Leu Ser Leu Met Leu Glu Asp Leu 
    370                 375                 380                 


Pro Gln Glu Lys Pro Gln Ser Leu Glu Lys Val Asp Glu Lys 
385                 390                 395             


<210> 68
<211> 472
<212> PRT
<213> Homo sapiens

<400> 68
Met Arg Asp Asn Glu Lys Ala Trp Trp Gln Gln Trp Thr Ser His Thr 
1               5                   10                  15      


Gly Leu Glu Gly Trp Gly Gly Thr Gln Glu Asp Arg Met Gly Phe Gly 
            20                  25                  30          


Gly Ala Val Ala Ala Leu Arg Gly Arg Pro Ser Pro Leu Gln Ser Thr 
        35                  40                  45              


Ile His Glu Ser Tyr Gly Arg Pro Glu Glu Gln Val Leu Ile Asn Arg 
    50                  55                  60                  


Gln Glu Ile Thr Asn Lys Ala Asp Ala Trp Asp Met Gln Glu Phe Ile 
65                  70                  75                  80  


Thr His Met Tyr Ile Lys Gln Leu Leu Arg His Pro Ala Phe Gln Leu 
                85                  90                  95      


Leu Leu Ala Leu Leu Leu Val Ile Asn Ala Ile Thr Ile Ala Leu Arg 
            100                 105                 110         


Thr Asn Ser Tyr Leu Asp Gln Lys His Tyr Glu Leu Phe Ser Thr Ile 
        115                 120                 125             


Asp Asp Ile Val Leu Thr Ile Leu Leu Cys Glu Val Leu Leu Gly Trp 
    130                 135                 140                 


Leu Asn Gly Phe Trp Ile Phe Trp Lys Asp Gly Trp Asn Ile Leu Asn 
145                 150                 155                 160 


Phe Ile Ile Val Phe Ile Leu Leu Leu Arg Phe Phe Ile Asn Glu Ile 
                165                 170                 175     


Asn Ile Pro Ser Ile Asn Tyr Thr Leu Arg Ala Leu Arg Leu Val His 
            180                 185                 190         


Val Cys Met Ala Val Glu Pro Leu Ala Arg Ile Ile Arg Val Ile Leu 
        195                 200                 205             


Gln Ser Val Pro Asp Met Ala Asn Ile Met Val Leu Ile Leu Phe Phe 
    210                 215                 220                 


Met Leu Val Phe Ser Val Phe Gly Val Thr Leu Phe Gly Ala Phe Val 
225                 230                 235                 240 


Pro Lys His Phe Gln Asn Ile Gln Val Ala Leu Tyr Thr Leu Phe Ile 
                245                 250                 255     


Cys Ile Thr Gln Asp Gly Trp Val Asp Ile Tyr Ser Asp Phe Gln Thr 
            260                 265                 270         


Glu Lys Arg Glu Tyr Ala Met Glu Ile Gly Gly Ala Ile Tyr Phe Thr 
        275                 280                 285             


Ile Phe Ile Thr Ile Gly Ala Phe Ile Gly Ile Asn Leu Phe Val Ile 
    290                 295                 300                 


Val Val Thr Thr Asn Leu Glu Gln Met Met Lys Ala Gly Glu Gln Gly 
305                 310                 315                 320 


Gln Gln Gln Arg Ile Thr Phe Ser Glu Thr Gly Ala Glu Glu Glu Glu 
                325                 330                 335     


Glu Asn Asp Gln Leu Pro Leu Val His Cys Val Val Ala Arg Ser Glu 
            340                 345                 350         


Lys Ser Gly Leu Leu Gln Glu Pro Leu Ala Gly Gly Pro Leu Ser Asn 
        355                 360                 365             


Leu Ser Glu Asn Thr Cys Asp Asn Phe Cys Leu Val Leu Glu Ala Ile 
    370                 375                 380                 


Gln Glu Asn Leu Arg Gln Tyr Lys Glu Ile Arg Asp Glu Leu Asn Met 
385                 390                 395                 400 


Ile Val Glu Glu Val Arg Ala Ile Arg Phe Asn Gln Glu Gln Glu Ser 
                405                 410                 415     


Glu Val Leu Asn Arg Arg Ser Ser Thr Ser Gly Ser Leu Glu Thr Thr 
            420                 425                 430         


Ser Ser Lys Asp Ile Arg Gln Met Ser Gln Gln Gln Asp Leu Leu Ser 
        435                 440                 445             


Ala Leu Val Ser Met Glu Lys Val His Asp Ser Ser Ser Gln Ile Leu 
    450                 455                 460                 


Leu Lys Lys His Lys Ser Ser His 
465                 470         


<210> 69
<211> 273
<212> PRT
<213> Homo sapiens

<400> 69
Met Ala Thr Trp Asp Glu Lys Ala Val Thr Arg Arg Ala Lys Val Ala 
1               5                   10                  15      


Pro Ala Glu Arg Met Ser Lys Phe Leu Arg His Phe Thr Val Val Gly 
            20                  25                  30          


Asp Asp Tyr His Ala Trp Asn Ile Asn Tyr Lys Lys Trp Glu Asn Glu 
        35                  40                  45              


Glu Glu Glu Glu Glu Glu Glu Gln Pro Pro Pro Thr Pro Val Ser Gly 
    50                  55                  60                  


Glu Glu Gly Arg Ala Ala Ala Pro Asp Val Ala Pro Ala Pro Gly Pro 
65                  70                  75                  80  


Ala Pro Arg Ala Pro Leu Asp Phe Arg Gly Met Leu Arg Lys Leu Phe 
                85                  90                  95      


Ser Ser His Arg Phe Gln Val Ile Ile Ile Cys Leu Val Val Leu Asp 
            100                 105                 110         


Ala Leu Leu Val Leu Ala Glu Leu Ile Leu Asp Leu Lys Ile Ile Gln 
        115                 120                 125             


Pro Asp Lys Asn Asn Tyr Ala Ala Met Val Phe His Tyr Met Ser Ile 
    130                 135                 140                 


Thr Ile Leu Val Phe Phe Met Met Glu Ile Ile Phe Lys Leu Phe Val 
145                 150                 155                 160 


Phe Arg Leu Glu Phe Phe His His Lys Phe Glu Ile Leu Asp Ala Val 
                165                 170                 175     


Val Val Val Val Ser Phe Ile Leu Asp Ile Val Leu Leu Phe Gln Glu 
            180                 185                 190         


His Gln Phe Glu Ala Leu Gly Leu Leu Ile Leu Leu Arg Leu Trp Arg 
        195                 200                 205             


Val Ala Arg Ile Ile Asn Gly Ile Ile Ile Ser Val Lys Thr Arg Ser 
    210                 215                 220                 


Glu Arg Gln Leu Leu Arg Leu Lys Gln Met Asn Val Gln Leu Ala Ala 
225                 230                 235                 240 


Lys Ile Gln His Leu Glu Phe Ser Cys Ser Glu Lys Glu Gln Glu Ile 
                245                 250                 255     


Glu Arg Leu Asn Lys Leu Leu Arg Gln His Gly Leu Leu Gly Glu Val 
            260                 265                 270         


Asn 
    


<210> 70
<211> 1182
<212> PRT
<213> Homo sapiens

<400> 70
Met Ala Asn Gly Gly Gly Gly Gly Gly Gly Ser Ser Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Ser Ser Leu Arg Met Ser Ser Asn Ile His Ala Asn 
            20                  25                  30          


His Leu Ser Leu Asp Ala Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
        35                  40                  45              


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Val His Glu Pro 
    50                  55                  60                  


Lys Met Asp Ala Leu Ile Ile Pro Val Thr Met Glu Val Pro Cys Asp 
65                  70                  75                  80  


Ser Arg Gly Gln Arg Met Trp Trp Ala Phe Leu Ala Ser Ser Met Val 
                85                  90                  95      


Thr Phe Phe Gly Gly Leu Phe Ile Ile Leu Leu Trp Arg Thr Leu Lys 
            100                 105                 110         


Tyr Leu Trp Thr Val Cys Cys His Cys Gly Gly Lys Thr Lys Glu Ala 
        115                 120                 125             


Gln Lys Ile Asn Asn Gly Ser Ser Gln Ala Asp Gly Thr Leu Lys Pro 
    130                 135                 140                 


Val Asp Glu Lys Glu Glu Ala Val Ala Ala Glu Val Gly Trp Met Thr 
145                 150                 155                 160 


Ser Val Lys Asp Trp Ala Gly Val Met Ile Ser Ala Gln Thr Leu Thr 
                165                 170                 175     


Gly Arg Val Leu Val Val Leu Val Phe Ala Leu Ser Ile Gly Ala Leu 
            180                 185                 190         


Val Ile Tyr Phe Ile Asp Ser Ser Asn Pro Ile Glu Ser Cys Gln Asn 
        195                 200                 205             


Phe Tyr Lys Asp Phe Thr Leu Gln Ile Asp Met Ala Phe Asn Val Phe 
    210                 215                 220                 


Phe Leu Leu Tyr Phe Gly Leu Arg Phe Ile Ala Ala Asn Asp Lys Leu 
225                 230                 235                 240 


Trp Phe Trp Leu Glu Val Asn Ser Val Val Asp Phe Phe Thr Val Pro 
                245                 250                 255     


Pro Val Phe Val Ser Val Tyr Leu Asn Arg Ser Trp Leu Gly Leu Arg 
            260                 265                 270         


Phe Leu Arg Ala Leu Arg Leu Ile Gln Phe Ser Glu Ile Leu Gln Phe 
        275                 280                 285             


Leu Asn Ile Leu Lys Thr Ser Asn Ser Ile Lys Leu Val Asn Leu Leu 
    290                 295                 300                 


Ser Ile Phe Ile Ser Thr Trp Leu Thr Ala Ala Gly Phe Ile His Leu 
305                 310                 315                 320 


Val Glu Asn Ser Gly Asp Pro Trp Glu Asn Phe Gln Asn Asn Gln Ala 
                325                 330                 335     


Leu Thr Tyr Trp Glu Cys Val Tyr Leu Leu Met Val Thr Met Ser Thr 
            340                 345                 350         


Val Gly Tyr Gly Asp Val Tyr Ala Lys Thr Thr Leu Gly Arg Leu Phe 
        355                 360                 365             


Met Val Phe Phe Ile Leu Gly Gly Leu Ala Met Phe Ala Ser Tyr Val 
    370                 375                 380                 


Pro Glu Ile Ile Glu Leu Ile Gly Asn Arg Lys Lys Tyr Gly Gly Ser 
385                 390                 395                 400 


Tyr Ser Ala Val Ser Gly Arg Lys His Ile Val Val Cys Gly His Ile 
                405                 410                 415     


Thr Leu Glu Ser Val Ser Asn Phe Leu Lys Asp Phe Leu His Lys Asp 
            420                 425                 430         


Arg Asp Asp Val Asn Val Glu Ile Val Phe Leu His Asn Ile Ser Pro 
        435                 440                 445             


Asn Leu Glu Leu Glu Ala Leu Phe Lys Arg His Phe Thr Gln Val Glu 
    450                 455                 460                 


Phe Tyr Gln Gly Ser Val Leu Asn Pro His Asp Leu Ala Arg Val Lys 
465                 470                 475                 480 


Ile Glu Ser Ala Asp Ala Cys Leu Ile Leu Ala Asn Lys Tyr Cys Ala 
                485                 490                 495     


Asp Pro Asp Ala Glu Asp Ala Ser Asn Ile Met Arg Val Ile Ser Ile 
            500                 505                 510         


Lys Asn Tyr His Pro Lys Ile Arg Ile Ile Thr Gln Met Leu Gln Tyr 
        515                 520                 525             


His Asn Lys Ala His Leu Leu Asn Ile Pro Ser Trp Asn Trp Lys Glu 
    530                 535                 540                 


Gly Asp Asp Ala Ile Cys Leu Ala Glu Leu Lys Leu Gly Phe Ile Ala 
545                 550                 555                 560 


Gln Ser Cys Leu Ala Gln Gly Leu Ser Thr Met Leu Ala Asn Leu Phe 
                565                 570                 575     


Ser Met Arg Ser Phe Ile Lys Ile Glu Glu Asp Thr Trp Gln Lys Tyr 
            580                 585                 590         


Tyr Leu Glu Gly Val Ser Asn Glu Met Tyr Thr Glu Tyr Leu Ser Ser 
        595                 600                 605             


Ala Phe Val Gly Leu Ser Phe Pro Thr Val Cys Glu Leu Cys Phe Val 
    610                 615                 620                 


Lys Leu Lys Leu Leu Met Ile Ala Ile Glu Tyr Lys Ser Ala Asn Arg 
625                 630                 635                 640 


Glu Ser Arg Ser Arg Lys Arg Ile Leu Ile Asn Pro Gly Asn His Leu 
                645                 650                 655     


Lys Ile Gln Glu Gly Thr Leu Gly Phe Phe Ile Ala Ser Asp Ala Lys 
            660                 665                 670         


Glu Val Lys Arg Ala Phe Phe Tyr Cys Lys Ala Cys His Asp Asp Ile 
        675                 680                 685             


Thr Asp Pro Lys Arg Ile Lys Lys Cys Gly Cys Lys Arg Leu Glu Asp 
    690                 695                 700                 


Glu Gln Pro Ser Thr Leu Ser Pro Lys Lys Lys Gln Arg Asn Gly Gly 
705                 710                 715                 720 


Met Arg Asn Ser Pro Asn Thr Ser Pro Lys Leu Met Arg His Asp Pro 
                725                 730                 735     


Leu Leu Ile Pro Gly Asn Asp Gln Ile Asp Asn Met Asp Ser Asn Val 
            740                 745                 750         


Lys Lys Tyr Asp Ser Thr Gly Met Phe His Trp Cys Ala Pro Lys Glu 
        755                 760                 765             


Ile Glu Lys Val Ile Leu Thr Arg Ser Glu Ala Ala Met Thr Val Leu 
    770                 775                 780                 


Ser Gly His Val Val Val Cys Ile Phe Gly Asp Val Ser Ser Ala Leu 
785                 790                 795                 800 


Ile Gly Leu Arg Asn Leu Val Met Pro Leu Arg Ala Ser Asn Phe His 
                805                 810                 815     


Tyr His Glu Leu Lys His Ile Val Phe Val Gly Ser Ile Glu Tyr Leu 
            820                 825                 830         


Lys Arg Glu Trp Glu Thr Leu His Asn Phe Pro Lys Val Ser Ile Leu 
        835                 840                 845             


Pro Gly Thr Pro Leu Ser Arg Ala Asp Leu Arg Ala Val Asn Ile Asn 
    850                 855                 860                 


Leu Cys Asp Met Cys Val Ile Leu Ser Ala Asn Gln Asn Asn Ile Asp 
865                 870                 875                 880 


Asp Thr Ser Leu Gln Asp Lys Glu Cys Ile Leu Ala Ser Leu Asn Ile 
                885                 890                 895     


Lys Ser Met Gln Phe Asp Asp Ser Ile Gly Val Leu Gln Ala Asn Ser 
            900                 905                 910         


Gln Gly Phe Thr Pro Pro Gly Met Asp Arg Ser Ser Pro Asp Asn Ser 
        915                 920                 925             


Pro Val His Gly Met Leu Arg Gln Pro Ser Ile Thr Thr Gly Val Asn 
    930                 935                 940                 


Ile Pro Ile Ile Thr Glu Leu Val Asn Asp Thr Asn Val Gln Phe Leu 
945                 950                 955                 960 


Asp Gln Asp Asp Asp Asp Asp Pro Asp Thr Glu Leu Tyr Leu Thr Gln 
                965                 970                 975     


Pro Phe Ala Cys Gly Thr Ala Phe Ala Val Ser Val Leu Asp Ser Leu 
            980                 985                 990         


Met Ser Ala Thr Tyr Phe Asn Asp  Asn Ile Leu Thr Leu  Ile Arg Thr 
        995                 1000                 1005             


Leu Val  Thr Gly Gly Ala Thr  Pro Glu Leu Glu Ala  Leu Ile Ala 
    1010                 1015                 1020             


Glu Glu  Asn Ala Leu Arg Gly  Gly Tyr Ser Thr Pro  Gln Thr Leu 
    1025                 1030                 1035             


Ala Asn  Arg Asp Arg Cys Arg  Val Ala Gln Leu Ala  Leu Leu Asp 
    1040                 1045                 1050             


Gly Pro  Phe Ala Asp Leu Gly  Asp Gly Gly Cys Tyr  Gly Asp Leu 
    1055                 1060                 1065             


Phe Cys  Lys Ala Leu Lys Thr  Tyr Asn Met Leu Cys  Phe Gly Ile 
    1070                 1075                 1080             


Tyr Arg  Leu Arg Asp Ala His  Leu Ser Thr Pro Ser  Gln Cys Thr 
    1085                 1090                 1095             


Lys Arg  Tyr Val Ile Thr Asn  Pro Pro Tyr Glu Phe  Glu Leu Val 
    1100                 1105                 1110             


Pro Thr  Asp Leu Ile Phe Cys  Leu Met Gln Phe Asp  His Asn Ala 
    1115                 1120                 1125             


Gly Gln  Ser Arg Ala Ser Leu  Ser His Ser Ser His  Ser Ser Gln 
    1130                 1135                 1140             


Ser Ser  Ser Lys Lys Ser Ser  Ser Val His Ser Ile  Pro Ser Thr 
    1145                 1150                 1155             


Ala Asn  Arg Gln Asn Arg Pro  Lys Ser Arg Glu Ser  Arg Asp Lys 
    1160                 1165                 1170             


Gln Asn  Arg Lys Glu Met Val  Tyr Arg 
    1175                 1180         


<210> 71
<211> 1235
<212> PRT
<213> Homo sapiens

<400> 71
Met Pro Leu Pro Asp Gly Ala Arg Thr Pro Gly Gly Val Cys Arg Glu 
1               5                   10                  15      


Ala Arg Gly Gly Gly Tyr Thr Asn Arg Thr Phe Glu Phe Asp Asp Gly 
            20                  25                  30          


Gln Cys Ala Pro Arg Arg Pro Cys Ala Gly Asp Gly Ala Leu Leu Asp 
        35                  40                  45              


Thr Ala Gly Phe Lys Met Ser Asp Leu Asp Ser Glu Val Leu Pro Leu 
    50                  55                  60                  


Pro Pro Arg Tyr Arg Phe Arg Asp Leu Leu Leu Gly Asp Pro Ser Phe 
65                  70                  75                  80  


Gln Asn Asp Asp Arg Val Gln Val Glu Phe Tyr Val Asn Glu Asn Thr 
                85                  90                  95      


Phe Lys Glu Arg Leu Lys Leu Phe Phe Ile Lys Asn Gln Arg Ser Ser 
            100                 105                 110         


Leu Arg Ile Arg Leu Phe Asn Phe Ser Leu Lys Leu Leu Thr Cys Leu 
        115                 120                 125             


Leu Tyr Ile Val Arg Val Leu Leu Asp Asp Pro Ala Leu Gly Ile Gly 
    130                 135                 140                 


Cys Trp Gly Cys Pro Lys Gln Asn Tyr Ser Phe Asn Asp Ser Ser Ser 
145                 150                 155                 160 


Glu Ile Asn Trp Ala Pro Ile Leu Trp Val Glu Arg Lys Met Thr Leu 
                165                 170                 175     


Trp Ala Ile Gln Val Ile Val Ala Ile Ile Ser Phe Leu Glu Thr Met 
            180                 185                 190         


Leu Leu Ile Tyr Leu Ser Tyr Lys Gly Asn Ile Trp Glu Gln Ile Phe 
        195                 200                 205             


Arg Val Ser Phe Val Leu Glu Met Ile Asn Thr Leu Pro Phe Ile Ile 
    210                 215                 220                 


Thr Ile Phe Trp Pro Pro Leu Arg Asn Leu Phe Ile Pro Val Phe Leu 
225                 230                 235                 240 


Asn Cys Trp Leu Ala Lys His Ala Leu Glu Asn Met Ile Asn Asp Phe 
                245                 250                 255     


His Arg Ala Ile Leu Arg Thr Gln Ser Ala Met Phe Asn Gln Val Leu 
            260                 265                 270         


Ile Leu Phe Cys Thr Leu Leu Cys Leu Val Phe Thr Gly Thr Cys Gly 
        275                 280                 285             


Ile Gln His Leu Glu Arg Ala Gly Glu Asn Leu Ser Leu Leu Thr Ser 
    290                 295                 300                 


Phe Tyr Phe Cys Ile Val Thr Phe Ser Thr Val Gly Tyr Gly Asp Val 
305                 310                 315                 320 


Thr Pro Lys Ile Trp Pro Ser Gln Leu Leu Val Val Ile Met Ile Cys 
                325                 330                 335     


Val Ala Leu Val Val Leu Pro Leu Gln Phe Glu Glu Leu Val Tyr Leu 
            340                 345                 350         


Trp Met Glu Arg Gln Lys Ser Gly Gly Asn Tyr Ser Arg His Arg Ala 
        355                 360                 365             


Gln Thr Glu Lys His Val Val Leu Cys Val Ser Ser Leu Lys Ile Asp 
    370                 375                 380                 


Leu Leu Met Asp Phe Leu Asn Glu Phe Tyr Ala His Pro Arg Leu Gln 
385                 390                 395                 400 


Asp Tyr Tyr Val Val Ile Leu Cys Pro Thr Glu Met Asp Val Gln Val 
                405                 410                 415     


Arg Arg Val Leu Gln Ile Pro Leu Trp Ser Gln Arg Val Ile Tyr Leu 
            420                 425                 430         


Gln Gly Ser Ala Leu Lys Asp Gln Asp Leu Met Arg Ala Lys Met Asp 
        435                 440                 445             


Asn Gly Glu Ala Cys Phe Ile Leu Ser Ser Arg Asn Glu Val Asp Arg 
    450                 455                 460                 


Thr Ala Ala Asp His Gln Thr Ile Leu Arg Ala Trp Ala Val Lys Asp 
465                 470                 475                 480 


Phe Ala Pro Asn Cys Pro Leu Tyr Val Gln Ile Leu Lys Pro Glu Asn 
                485                 490                 495     


Lys Phe His Val Lys Phe Ala Asp His Val Val Cys Glu Glu Glu Cys 
            500                 505                 510         


Lys Tyr Ala Met Leu Ala Leu Asn Cys Ile Cys Pro Ala Thr Ser Thr 
        515                 520                 525             


Leu Ile Thr Leu Leu Val His Thr Ser Arg Gly Gln Glu Gly Gln Glu 
    530                 535                 540                 


Ser Pro Glu Gln Trp Gln Arg Met Tyr Gly Arg Cys Ser Gly Asn Glu 
545                 550                 555                 560 


Val Tyr His Ile Arg Met Gly Asp Ser Lys Phe Phe Arg Glu Tyr Glu 
                565                 570                 575     


Gly Lys Ser Phe Thr Tyr Ala Ala Phe His Ala His Lys Lys Tyr Gly 
            580                 585                 590         


Val Cys Leu Ile Gly Leu Lys Arg Glu Asp Asn Lys Ser Ile Leu Leu 
        595                 600                 605             


Asn Pro Gly Pro Arg His Ile Leu Ala Ala Ser Asp Thr Cys Phe Tyr 
    610                 615                 620                 


Ile Asn Ile Thr Lys Glu Glu Asn Ser Ala Phe Ile Phe Lys Gln Glu 
625                 630                 635                 640 


Glu Lys Arg Lys Lys Arg Ala Phe Ser Gly Gln Gly Leu His Glu Gly 
                645                 650                 655     


Pro Ala Arg Leu Pro Val His Ser Ile Ile Ala Ser Met Gly Thr Val 
            660                 665                 670         


Ala Met Asp Leu Gln Gly Thr Glu His Arg Pro Thr Gln Ser Gly Gly 
        675                 680                 685             


Gly Gly Gly Gly Ser Lys Leu Ala Leu Pro Thr Glu Asn Gly Ser Gly 
    690                 695                 700                 


Ser Arg Arg Pro Ser Ile Ala Pro Val Leu Glu Leu Ala Asp Ser Ser 
705                 710                 715                 720 


Ala Leu Leu Pro Cys Asp Leu Leu Ser Asp Gln Ser Glu Asp Glu Val 
                725                 730                 735     


Thr Pro Ser Asp Asp Glu Gly Leu Ser Val Val Glu Tyr Val Lys Gly 
            740                 745                 750         


Tyr Pro Pro Asn Ser Pro Tyr Ile Gly Ser Ser Pro Thr Leu Cys His 
        755                 760                 765             


Leu Leu Pro Val Lys Ala Pro Phe Cys Cys Leu Arg Leu Asp Lys Gly 
    770                 775                 780                 


Cys Lys His Asn Ser Tyr Glu Asp Ala Lys Ala Tyr Gly Phe Lys Asn 
785                 790                 795                 800 


Lys Leu Ile Ile Val Ser Ala Glu Thr Ala Gly Asn Gly Leu Tyr Asn 
                805                 810                 815     


Phe Ile Val Pro Leu Arg Ala Tyr Tyr Arg Ser Arg Lys Glu Leu Asn 
            820                 825                 830         


Pro Ile Val Leu Leu Leu Asp Asn Lys Pro Asp His His Phe Leu Glu 
        835                 840                 845             


Ala Ile Cys Cys Phe Pro Met Val Tyr Tyr Met Glu Gly Ser Val Asp 
    850                 855                 860                 


Asn Leu Asp Ser Leu Leu Gln Cys Gly Ile Ile Tyr Ala Asp Asn Leu 
865                 870                 875                 880 


Val Val Val Asp Lys Glu Ser Thr Met Ser Ala Glu Glu Asp Tyr Met 
                885                 890                 895     


Ala Asp Ala Lys Thr Ile Val Asn Val Gln Thr Met Phe Arg Leu Phe 
            900                 905                 910         


Pro Ser Leu Ser Ile Thr Thr Glu Leu Thr His Pro Ser Asn Met Arg 
        915                 920                 925             


Phe Met Gln Phe Arg Ala Lys Asp Ser Tyr Ser Leu Ala Leu Ser Lys 
    930                 935                 940                 


Leu Glu Lys Arg Glu Arg Glu Asn Gly Ser Asn Leu Ala Phe Met Phe 
945                 950                 955                 960 


Arg Leu Pro Phe Ala Ala Gly Arg Val Phe Ser Ile Ser Met Leu Asp 
                965                 970                 975     


Thr Leu Leu Tyr Gln Ser Phe Val Lys Asp Tyr Met Ile Thr Ile Thr 
            980                 985                 990         


Arg Leu Leu Leu Gly Leu Asp Thr  Thr Pro Gly Ser Gly  Tyr Leu Cys 
        995                 1000                 1005             


Ala Met  Lys Ile Thr Glu Gly  Asp Leu Trp Ile Arg  Thr Tyr Gly 
    1010                 1015                 1020             


Arg Leu  Phe Gln Lys Leu Cys  Ser Ser Ser Ala Glu  Ile Pro Ile 
    1025                 1030                 1035             


Gly Ile  Tyr Arg Thr Glu Ser  His Val Phe Ser Thr  Ser Glu Pro 
    1040                 1045                 1050             


His Asp  Leu Arg Ala Gln Ser  Gln Ile Ser Val Asn  Val Glu Asp 
    1055                 1060                 1065             


Cys Glu  Asp Thr Arg Glu Val  Lys Gly Pro Trp Gly  Ser Arg Ala 
    1070                 1075                 1080             


Gly Thr  Gly Gly Ser Ser Gln  Gly Arg His Thr Gly  Gly Gly Asp 
    1085                 1090                 1095             


Pro Ala  Glu His Pro Leu Leu  Arg Arg Lys Ser Leu  Gln Trp Ala 
    1100                 1105                 1110             


Arg Arg  Leu Ser Arg Lys Ala  Pro Lys Gln Ala Gly  Arg Ala Ala 
    1115                 1120                 1125             


Ala Ala  Glu Trp Ile Ser Gln  Gln Arg Leu Ser Leu  Tyr Arg Arg 
    1130                 1135                 1140             


Ser Glu  Arg Gln Glu Leu Ser  Glu Leu Val Lys Asn  Arg Met Lys 
    1145                 1150                 1155             


His Leu  Gly Leu Pro Thr Thr  Gly Tyr Asp Glu Met  Asn Asp His 
    1160                 1165                 1170             


Gln Asn  Thr Leu Ser Tyr Val  Leu Ile Asn Pro Pro  Pro Asp Thr 
    1175                 1180                 1185             


Arg Leu  Glu Pro Ser Asp Ile  Val Tyr Leu Ile Arg  Ser Asp Pro 
    1190                 1195                 1200             


Leu Ala  His Val Ala Ser Ser  Ser Gln Ser Arg Lys  Ser Ser Cys 
    1205                 1210                 1215             


Ser His  Lys Leu Ser Ser Cys  Asn Pro Glu Thr Arg  Asp Glu Thr 
    1220                 1225                 1230             


Gln Leu  
    1235 


<210> 72
<211> 1135
<212> PRT
<213> Homo sapiens

<400> 72
Met Val Asp Leu Glu Ser Glu Val Pro Pro Leu Pro Pro Arg Tyr Arg 
1               5                   10                  15      


Phe Arg Asp Leu Leu Leu Gly Asp Gln Gly Trp Gln Asn Asp Asp Arg 
            20                  25                  30          


Val Gln Val Glu Phe Tyr Met Asn Glu Asn Thr Phe Lys Glu Arg Leu 
        35                  40                  45              


Lys Leu Phe Phe Ile Lys Asn Gln Arg Ser Ser Leu Arg Ile Arg Leu 
    50                  55                  60                  


Phe Asn Phe Ser Leu Lys Leu Leu Ser Cys Leu Leu Tyr Ile Ile Arg 
65                  70                  75                  80  


Val Leu Leu Glu Asn Pro Ser Gln Gly Asn Glu Trp Ser His Ile Phe 
                85                  90                  95      


Trp Val Asn Arg Ser Leu Pro Leu Trp Gly Leu Gln Val Ser Val Ala 
            100                 105                 110         


Leu Ile Ser Leu Phe Glu Thr Ile Leu Leu Gly Tyr Leu Ser Tyr Lys 
        115                 120                 125             


Gly Asn Ile Trp Glu Gln Ile Leu Arg Ile Pro Phe Ile Leu Glu Ile 
    130                 135                 140                 


Ile Asn Ala Val Pro Phe Ile Ile Ser Ile Phe Trp Pro Ser Leu Arg 
145                 150                 155                 160 


Asn Leu Phe Val Pro Val Phe Leu Asn Cys Trp Leu Ala Lys His Ala 
                165                 170                 175     


Leu Glu Asn Met Ile Asn Asp Leu His Arg Ala Ile Gln Arg Thr Gln 
            180                 185                 190         


Ser Ala Met Phe Asn Gln Val Leu Ile Leu Ile Ser Thr Leu Leu Cys 
        195                 200                 205             


Leu Ile Phe Thr Cys Ile Cys Gly Ile Gln His Leu Glu Arg Ile Gly 
    210                 215                 220                 


Lys Lys Leu Asn Leu Phe Asp Ser Leu Tyr Phe Cys Ile Val Thr Phe 
225                 230                 235                 240 


Ser Thr Val Gly Phe Gly Asp Val Thr Pro Glu Thr Trp Ser Ser Lys 
                245                 250                 255     


Leu Phe Val Val Ala Met Ile Cys Val Ala Leu Val Val Leu Pro Ile 
            260                 265                 270         


Gln Phe Glu Gln Leu Ala Tyr Leu Trp Met Glu Arg Gln Lys Ser Gly 
        275                 280                 285             


Gly Asn Tyr Ser Arg His Arg Ala Gln Thr Glu Lys His Val Val Leu 
    290                 295                 300                 


Cys Val Ser Ser Leu Lys Ile Asp Leu Leu Met Asp Phe Leu Asn Glu 
305                 310                 315                 320 


Phe Tyr Ala His Pro Arg Leu Gln Asp Tyr Tyr Val Val Ile Leu Cys 
                325                 330                 335     


Pro Thr Glu Met Asp Val Gln Val Arg Arg Val Leu Gln Ile Pro Met 
            340                 345                 350         


Trp Ser Gln Arg Val Ile Tyr Leu Gln Gly Ser Ala Leu Lys Asp Gln 
        355                 360                 365             


Asp Leu Leu Arg Ala Lys Met Asp Asp Ala Glu Ala Cys Phe Ile Leu 
    370                 375                 380                 


Ser Ser Arg Cys Glu Val Asp Arg Thr Ser Ser Asp His Gln Thr Ile 
385                 390                 395                 400 


Leu Arg Ala Trp Ala Val Lys Asp Phe Ala Pro Asn Cys Pro Leu Tyr 
                405                 410                 415     


Val Gln Ile Leu Lys Pro Glu Asn Lys Phe His Ile Lys Phe Ala Asp 
            420                 425                 430         


His Val Val Cys Glu Glu Glu Phe Lys Tyr Ala Met Leu Ala Leu Asn 
        435                 440                 445             


Cys Ile Cys Pro Ala Thr Ser Thr Leu Ile Thr Leu Leu Val His Thr 
    450                 455                 460                 


Ser Arg Gly Gln Glu Gly Gln Gln Ser Pro Glu Gln Trp Gln Lys Met 
465                 470                 475                 480 


Tyr Gly Arg Cys Ser Gly Asn Glu Val Tyr His Ile Val Leu Glu Glu 
                485                 490                 495     


Ser Thr Phe Phe Ala Glu Tyr Glu Gly Lys Ser Phe Thr Tyr Ala Ser 
            500                 505                 510         


Phe His Ala His Lys Lys Phe Gly Val Cys Leu Ile Gly Val Arg Arg 
        515                 520                 525             


Glu Asp Asn Lys Asn Ile Leu Leu Asn Pro Gly Pro Arg Tyr Ile Met 
    530                 535                 540                 


Asn Ser Thr Asp Ile Cys Phe Tyr Ile Asn Ile Thr Lys Glu Glu Asn 
545                 550                 555                 560 


Ser Ala Phe Lys Asn Gln Asp Gln Gln Arg Lys Ser Asn Val Ser Arg 
                565                 570                 575     


Ser Phe Tyr His Gly Pro Ser Arg Leu Pro Val His Ser Ile Ile Ala 
            580                 585                 590         


Ser Met Gly Thr Val Ala Ile Asp Leu Gln Asp Thr Ser Cys Arg Ser 
        595                 600                 605             


Ala Ser Gly Pro Thr Leu Ser Leu Pro Thr Glu Gly Ser Lys Glu Ile 
    610                 615                 620                 


Arg Arg Pro Ser Ile Ala Pro Val Leu Glu Val Ala Asp Thr Ser Ser 
625                 630                 635                 640 


Ile Gln Thr Cys Asp Leu Leu Ser Asp Gln Ser Glu Asp Glu Thr Thr 
                645                 650                 655     


Pro Asp Glu Glu Met Ser Ser Asn Leu Glu Tyr Ala Lys Gly Tyr Pro 
            660                 665                 670         


Pro Tyr Ser Pro Tyr Ile Gly Ser Ser Pro Thr Phe Cys His Leu Leu 
        675                 680                 685             


His Glu Lys Val Pro Phe Cys Cys Leu Arg Leu Asp Lys Ser Cys Gln 
    690                 695                 700                 


His Asn Tyr Tyr Glu Asp Ala Lys Ala Tyr Gly Phe Lys Asn Lys Leu 
705                 710                 715                 720 


Ile Ile Val Ala Ala Glu Thr Ala Gly Asn Gly Leu Tyr Asn Phe Ile 
                725                 730                 735     


Val Pro Leu Arg Ala Tyr Tyr Arg Pro Lys Lys Glu Leu Asn Pro Ile 
            740                 745                 750         


Val Leu Leu Leu Asp Asn Pro Pro Asp Met His Phe Leu Asp Ala Ile 
        755                 760                 765             


Cys Trp Phe Pro Met Val Tyr Tyr Met Val Gly Ser Ile Asp Asn Leu 
    770                 775                 780                 


Asp Asp Leu Leu Arg Cys Gly Val Thr Phe Ala Ala Asn Met Val Val 
785                 790                 795                 800 


Val Asp Lys Glu Ser Thr Met Ser Ala Glu Glu Asp Tyr Met Ala Asp 
                805                 810                 815     


Ala Lys Thr Ile Val Asn Val Gln Thr Leu Phe Arg Leu Phe Ser Ser 
            820                 825                 830         


Leu Ser Ile Ile Thr Glu Leu Thr His Pro Ala Asn Met Arg Phe Met 
        835                 840                 845             


Gln Phe Arg Ala Lys Asp Cys Tyr Ser Leu Ala Leu Ser Lys Leu Glu 
    850                 855                 860                 


Lys Lys Glu Arg Glu Arg Gly Ser Asn Leu Ala Phe Met Phe Arg Leu 
865                 870                 875                 880 


Pro Phe Ala Ala Gly Arg Val Phe Ser Ile Ser Met Leu Asp Thr Leu 
                885                 890                 895     


Leu Tyr Gln Ser Phe Val Lys Asp Tyr Met Ile Ser Ile Thr Arg Leu 
            900                 905                 910         


Leu Leu Gly Leu Asp Thr Thr Pro Gly Ser Gly Phe Leu Cys Ser Met 
        915                 920                 925             


Lys Ile Thr Ala Asp Asp Leu Trp Ile Arg Thr Tyr Ala Arg Leu Tyr 
    930                 935                 940                 


Gln Lys Leu Cys Ser Ser Thr Gly Asp Val Pro Ile Gly Ile Tyr Arg 
945                 950                 955                 960 


Thr Glu Ser Gln Lys Leu Thr Thr Ser Glu Ser Gln Ile Ser Ile Ser 
                965                 970                 975     


Val Glu Glu Trp Glu Asp Thr Lys Asp Ser Lys Glu Gln Gly His His 
            980                 985                 990         


Arg Ser Asn His Arg Asn Ser Thr  Ser Ser Asp Gln Ser  Asp His Pro 
        995                 1000                 1005             


Leu Leu  Arg Arg Lys Ser Met  Gln Trp Ala Arg Arg  Leu Ser Arg 
    1010                 1015                 1020             


Lys Gly  Pro Lys His Ser Gly  Lys Thr Ala Glu Lys  Ile Thr Gln 
    1025                 1030                 1035             


Gln Arg  Leu Asn Leu Tyr Arg  Arg Ser Glu Arg Gln  Glu Leu Ala 
    1040                 1045                 1050             


Glu Leu  Val Lys Asn Arg Met  Lys His Leu Gly Leu  Ser Thr Val 
    1055                 1060                 1065             


Gly Tyr  Asp Glu Met Asn Asp  His Gln Ser Thr Leu  Ser Tyr Ile 
    1070                 1075                 1080             


Leu Ile  Asn Pro Ser Pro Asp  Thr Arg Ile Glu Leu  Asn Asp Val 
    1085                 1090                 1095             


Val Tyr  Leu Ile Arg Pro Asp  Pro Leu Ala Tyr Leu  Pro Asn Ser 
    1100                 1105                 1110             


Glu Pro  Ser Arg Arg Asn Ser  Ile Cys Asn Val Thr  Gly Gln Asp 
    1115                 1120                 1125             


Ser Arg  Glu Glu Thr Gln Leu  
    1130                 1135 


<210> 73
<211> 888
<212> PRT
<213> Homo sapiens

<400> 73
Met Glu Ser Cys Tyr Ile Ala Gln Ala Gly Leu Glu Leu Leu Gly Ser 
1               5                   10                  15      


Ser Ser Ser Pro Thr Leu Thr Ser Gln Ser Ala Glu Ile Thr Glu Asp 
            20                  25                  30          


Ala Ser Asn Gly Gly Val Ser Glu Gln His Pro Trp Pro Ser Gly Phe 
        35                  40                  45              


Glu Arg Glu Leu Lys Pro Glu Thr Ile Ser Ser Pro Gly Tyr His Ile 
    50                  55                  60                  


Leu Arg Ala Thr Gly Glu Glu Asn Met Ala Val Ser Leu Asp Asp Asp 
65                  70                  75                  80  


Val Pro Leu Ile Leu Thr Leu Asp Glu Gly Gly Ser Ala Pro Leu Ala 
                85                  90                  95      


Pro Ser Asn Gly Leu Gly Gln Glu Glu Leu Pro Ser Lys Asn Gly Gly 
            100                 105                 110         


Ser Tyr Ala Ile His Asp Ser Gln Ala Pro Ser Leu Ser Ser Gly Gly 
        115                 120                 125             


Glu Ser Ser Pro Ser Ser Pro Ala His Asn Trp Glu Met Asn Tyr Gln 
    130                 135                 140                 


Glu Ala Ala Ile Tyr Leu Gln Glu Gly Glu Asn Asn Asp Lys Phe Phe 
145                 150                 155                 160 


Thr His Pro Lys Asp Ala Lys Ala Leu Ala Ala Tyr Leu Phe Ala His 
                165                 170                 175     


Asn His Leu Phe Tyr Leu Met Glu Leu Ala Thr Ala Leu Leu Leu Leu 
            180                 185                 190         


Leu Leu Ser Leu Cys Glu Ala Pro Ala Val Pro Ala Leu Arg Leu Gly 
        195                 200                 205             


Ile Tyr Val His Ala Thr Leu Glu Leu Phe Ala Leu Met Val Val Val 
    210                 215                 220                 


Phe Glu Leu Cys Met Lys Leu Arg Trp Leu Gly Leu His Thr Phe Ile 
225                 230                 235                 240 


Arg His Lys Arg Thr Met Val Lys Thr Ser Val Leu Val Val Gln Phe 
                245                 250                 255     


Val Glu Ala Ile Val Val Leu Val Arg Gln Met Ser His Val Arg Val 
            260                 265                 270         


Thr Arg Ala Leu Arg Cys Ile Phe Leu Val Asp Cys Arg Tyr Cys Gly 
        275                 280                 285             


Gly Val Arg Arg Asn Leu Arg Gln Ile Phe Gln Ser Leu Pro Pro Phe 
    290                 295                 300                 


Met Asp Ile Leu Leu Leu Leu Leu Phe Phe Met Ile Ile Phe Ala Ile 
305                 310                 315                 320 


Leu Gly Phe Tyr Leu Phe Ser Pro Asn Pro Ser Asp Pro Tyr Phe Ser 
                325                 330                 335     


Thr Leu Glu Asn Ser Ile Val Ser Leu Phe Val Leu Leu Thr Thr Ala 
            340                 345                 350         


Asn Phe Pro Asp Val Met Met Pro Ser Tyr Ser Arg Asn Pro Trp Ser 
        355                 360                 365             


Cys Val Phe Phe Ile Val Tyr Leu Ser Ile Glu Leu Tyr Phe Ile Met 
    370                 375                 380                 


Asn Leu Leu Leu Ala Val Val Phe Asp Thr Phe Asn Asp Ile Glu Lys 
385                 390                 395                 400 


Arg Lys Phe Lys Ser Leu Leu Leu His Lys Arg Thr Ala Ile Gln His 
                405                 410                 415     


Ala Tyr Arg Leu Leu Ile Ser Gln Arg Arg Pro Ala Gly Ile Ser Tyr 
            420                 425                 430         


Arg Gln Phe Glu Gly Leu Met Arg Phe Tyr Lys Pro Arg Met Ser Ala 
        435                 440                 445             


Arg Glu Arg Tyr Leu Thr Phe Lys Ala Leu Asn Gln Asn Asn Thr Pro 
    450                 455                 460                 


Leu Leu Ser Leu Lys Asp Phe Tyr Asp Ile Tyr Glu Val Ala Ala Leu 
465                 470                 475                 480 


Lys Trp Lys Ala Lys Lys Asn Arg Glu His Trp Phe Asp Glu Leu Pro 
                485                 490                 495     


Arg Thr Ala Leu Leu Ile Phe Lys Gly Ile Asn Ile Leu Val Lys Ser 
            500                 505                 510         


Lys Ala Phe Gln Tyr Phe Met Tyr Leu Val Val Ala Val Asn Gly Val 
        515                 520                 525             


Trp Ile Leu Val Glu Thr Phe Met Leu Lys Gly Gly Asn Phe Phe Ser 
    530                 535                 540                 


Lys His Val Pro Trp Ser Tyr Leu Val Phe Leu Thr Ile Tyr Gly Val 
545                 550                 555                 560 


Glu Leu Phe Leu Lys Val Ala Gly Leu Gly Pro Val Glu Tyr Leu Ser 
                565                 570                 575     


Ser Gly Trp Asn Leu Phe Asp Phe Ser Val Thr Val Phe Ala Phe Leu 
            580                 585                 590         


Gly Leu Leu Ala Leu Ala Leu Asn Met Glu Pro Phe Tyr Phe Ile Val 
        595                 600                 605             


Val Leu Arg Pro Leu Gln Leu Leu Arg Leu Phe Lys Leu Lys Glu Arg 
    610                 615                 620                 


Tyr Arg Asn Val Leu Asp Thr Met Phe Glu Leu Leu Pro Arg Met Ala 
625                 630                 635                 640 


Ser Leu Gly Leu Thr Leu Leu Ile Phe Tyr Tyr Ser Phe Ala Ile Val 
                645                 650                 655     


Gly Met Glu Phe Phe Cys Gly Ile Val Phe Pro Asn Cys Cys Asn Thr 
            660                 665                 670         


Ser Thr Val Ala Asp Ala Tyr Arg Trp Arg Asn His Thr Val Gly Asn 
        675                 680                 685             


Arg Thr Val Val Glu Glu Gly Tyr Tyr Tyr Leu Asn Asn Phe Asp Asn 
    690                 695                 700                 


Ile Leu Asn Ser Phe Val Thr Leu Phe Glu Leu Thr Val Val Asn Asn 
705                 710                 715                 720 


Trp Tyr Ile Ile Met Glu Gly Val Thr Ser Gln Thr Ser His Trp Ser 
                725                 730                 735     


Arg Leu Tyr Phe Met Thr Phe Tyr Ile Val Thr Met Val Val Met Thr 
            740                 745                 750         


Ile Ile Val Ala Phe Ile Leu Glu Ala Phe Val Phe Arg Met Asn Tyr 
        755                 760                 765             


Ser Arg Lys Asn Gln Asp Ser Glu Val Asp Gly Gly Ile Thr Leu Glu 
    770                 775                 780                 


Lys Glu Ile Ser Lys Glu Glu Leu Val Ala Val Leu Glu Leu Tyr Arg 
785                 790                 795                 800 


Glu Ala Arg Gly Ala Ser Ser Asp Val Thr Arg Leu Leu Glu Thr Leu 
                805                 810                 815     


Ser Gln Met Glu Arg Tyr Gln Gln His Ser Met Val Phe Leu Gly Arg 
            820                 825                 830         


Arg Ser Arg Thr Lys Ser Asp Leu Ser Leu Lys Met Tyr Gln Glu Glu 
        835                 840                 845             


Ile Gln Glu Trp Tyr Glu Glu His Ala Arg Glu Gln Glu Gln Gln Arg 
    850                 855                 860                 


Gln Leu Ser Ser Ser Ala Ala Pro Ala Ala Gln Gln Pro Pro Gly Ser 
865                 870                 875                 880 


Arg Gln Arg Ser Gln Thr Val Thr 
                885             


<210> 74
<211> 141
<212> PRT
<213> Homo sapiens

<400> 74
Arg Lys Leu Phe Ser Ser His Arg Phe Gln Val Ile Ile Ile Cys Leu 
1               5                   10                  15      


Val Val Leu Asp Ala Leu Leu Val Leu Ala Glu Leu Ile Leu Asp Leu 
            20                  25                  30          


Lys Ile Ile Gln Pro Asp Lys Asn Asn Tyr Ala Ala Met Val Phe His 
        35                  40                  45              


Tyr Met Ser Ile Thr Ile Leu Val Phe Phe Met Met Glu Ile Ile Phe 
    50                  55                  60                  


Lys Leu Phe Val Phe Arg Leu Glu Phe Phe His His Lys Phe Glu Ile 
65                  70                  75                  80  


Leu Asp Ala Val Val Val Val Val Ser Phe Ile Leu Asp Ile Val Leu 
                85                  90                  95      


Leu Phe Gln Glu His Gln Phe Glu Ala Leu Gly Leu Leu Ile Leu Leu 
            100                 105                 110         


Arg Leu Trp Arg Val Ala Arg Ile Ile Asn Gly Ile Ile Ile Ser Val 
        115                 120                 125             


Lys Thr Arg Ser Glu Arg Gln Leu Leu Arg Leu Lys Gln 
    130                 135                 140     


<210> 75
<211> 141
<212> PRT
<213> Gallus gallus

<400> 75
Lys Lys Leu Phe Ser Ser Arg Arg Phe Gln Ile Val Ile Val Phe Leu 
1               5                   10                  15      


Val Ile Val Asp Ala Leu Leu Val Leu Gly Glu Leu Leu Met Asp Leu 
            20                  25                  30          


Lys Ile Ile His Pro Asp Lys Tyr His Ile Ala Pro Lys Val Phe His 
        35                  40                  45              


Tyr Leu Ser Leu Ser Ile Leu Thr Ile Phe Leu Val Glu Val Gly Phe 
    50                  55                  60                  


Lys Ile Phe Val Tyr Gly Arg Glu Phe Phe His His Lys Phe Glu Val 
65                  70                  75                  80  


Leu Asp Ser Ile Val Val Val Val Ser Phe Ile Leu Asp Leu Val Leu 
                85                  90                  95      


Leu Phe Arg Glu His Glu Phe Glu Ala Val Gly Leu Leu Ile Leu Leu 
            100                 105                 110         


Arg Leu Trp Arg Val Ala Arg Ile Ile Asn Gly Ile Ile Leu Ser Val 
        115                 120                 125             


Lys Thr Arg Ser Glu Gln Gln Val Ser Lys Leu Lys Gln 
    130                 135                 140     


<210> 76
<211> 141
<212> PRT
<213> Monodelphis sp.

<400> 76
Arg Lys Leu Phe Gly Ser His Arg Phe Gln Val Ile Ile Ile Cys Leu 
1               5                   10                  15      


Val Ile Met Asp Ala Leu Leu Val Leu Ala Glu Leu Met Leu Asp Leu 
            20                  25                  30          


Lys Ile Ile Gln Pro Asp Lys Asp Asn Tyr Ala Ala Arg Val Phe His 
        35                  40                  45              


Tyr Leu Ser Ile Ala Ile Leu Thr Phe Phe Met Ile Glu Val Ala Leu 
    50                  55                  60                  


Lys Leu Tyr Val Phe Arg Leu Glu Phe Phe Tyr His Lys Phe Glu Ile 
65                  70                  75                  80  


Leu Asp Ala Val Ile Val Ile Ile Ser Phe Val Leu Asp Ile Val Leu 
                85                  90                  95      


Leu Phe Gln Glu His Ala Phe Glu Ala Leu Gly Leu Leu Ile Leu Leu 
            100                 105                 110         


Arg Leu Trp Arg Val Ala Arg Ile Ile Asn Gly Ile Ile Ile Ser Val 
        115                 120                 125             


Lys Thr Arg Ser Glu Arg Gln Leu Ser Arg Leu Lys Leu 
    130                 135                 140     


<210> 77
<211> 141
<212> PRT
<213> Rattus norvegicus

<400> 77
Arg Lys Leu Phe Ser Ser His Arg Phe Gln Val Ile Ile Ile Cys Leu 
1               5                   10                  15      


Val Val Leu Asp Ala Leu Leu Val Leu Ala Glu Leu Leu Leu Asp Leu 
            20                  25                  30          


Arg Ile Ile Glu Pro Asp Leu Ser Lys Tyr Ser Thr Lys Val Phe His 
        35                  40                  45              


Tyr Leu Ser Leu Ala Ile Leu Ala Phe Phe Val Leu Glu Ile Ser Leu 
    50                  55                  60                  


Lys Val Phe Val Phe Arg Leu Glu Phe Phe His His Lys Phe Glu Ile 
65                  70                  75                  80  


Leu Asp Ala Ile Val Val Val Val Ser Phe Val Leu Asp Leu Ile Leu 
                85                  90                  95      


Leu Phe Lys Asn His His Phe Glu Ala Leu Gly Leu Leu Ile Leu Leu 
            100                 105                 110         


Arg Leu Trp Arg Val Ala Arg Ile Ile Asn Gly Ile Ile Ile Ser Val 
        115                 120                 125             


Lys Thr Arg Ser Glu Arg Gln Ile Leu Arg Leu Lys Gln 
    130                 135                 140     


<210> 78
<211> 141
<212> PRT
<213> Equus caballus

<400> 78
Arg Lys Leu Phe Ser Cys His Arg Phe Gln Val Ile Ile Ile Cys Leu 
1               5                   10                  15      


Val Ile Leu Asp Ala Leu Leu Val Leu Ala Glu Leu Ile Leu Asp Leu 
            20                  25                  30          


Lys Ile Ile Glu Ala Asp Lys Asn Asn Tyr Val Pro Arg Val Phe His 
        35                  40                  45              


Tyr Met Ser Leu Ala Ile Leu Thr Phe Phe Met Thr Glu Val Ser Leu 
    50                  55                  60                  


Lys Ile Phe Val Phe Arg Leu Glu Phe Phe His His Lys Phe Glu Ile 
65                  70                  75                  80  


Leu Asp Ala Val Val Val Val Val Ser Phe Val Leu Asp Ile Val Leu 
                85                  90                  95      


Ile Phe Arg Glu His Glu Phe Glu Ala Leu Gly Leu Leu Ile Leu Leu 
            100                 105                 110         


Arg Leu Trp Arg Val Ala Arg Ile Ile Asn Gly Ile Ile Ile Ser Val 
        115                 120                 125             


Lys Thr Arg Ser Glu Arg Gln Leu Leu Arg Leu Lys Gln 
    130                 135                 140     


<210> 79
<211> 141
<212> PRT
<213> Bos taurus

<400> 79
Arg Lys Leu Phe Ser Ala His Arg Phe Gln Val Ile Ile Ile Cys Leu 
1               5                   10                  15      


Val Val Leu Asp Ala Leu Leu Val Leu Ala Glu Leu Val Leu Asp Leu 
            20                  25                  30          


Lys Ile Ile Glu Pro Asp Lys Asn Asn Tyr Ala Pro Lys Val Phe His 
        35                  40                  45              


Tyr Met Ser Leu Ala Ile Leu Thr Phe Phe Met Met Glu Ile Phe Phe 
    50                  55                  60                  


Lys Ile Phe Val Phe Arg Leu Glu Phe Phe His His Lys Phe Glu Ile 
65                  70                  75                  80  


Leu Asp Thr Ile Val Val Val Ile Ser Phe Ile Leu Asp Leu Val Leu 
                85                  90                  95      


Leu Phe Arg Glu His Gln Phe Glu Ala Leu Gly Leu Leu Ile Leu Leu 
            100                 105                 110         


Arg Leu Trp Arg Val Ala Arg Ile Ile Asn Gly Ile Ile Ile Ser Val 
        115                 120                 125             


Lys Thr Arg Ser Glu Arg Gln Leu Leu Arg Leu Lys Gln 
    130                 135                 140     


<210> 80
<211> 141
<212> PRT
<213> Sus scrofa

<400> 80
Arg Lys Leu Phe Ser Ala His Arg Phe Gln Val Ile Ile Ile Cys Leu 
1               5                   10                  15      


Val Ile Leu Asp Ala Leu Leu Val Leu Ala Glu Leu Val Leu Asp Leu 
            20                  25                  30          


Lys Ile Ile Gln Pro Asp Lys Asn Asn Tyr Ala Asn Arg Val Phe His 
        35                  40                  45              


Tyr Met Ser Val Ala Ile Leu Thr Phe Phe Met Met Glu Ile Phe Phe 
    50                  55                  60                  


Lys Ile Phe Val Phe Arg Phe Glu Phe Phe His His Lys Phe Glu Ile 
65                  70                  75                  80  


Leu Asp Ala Ile Val Val Val Val Ser Phe Ile Leu Asp Val Val Leu 
                85                  90                  95      


Leu Phe Arg Glu His Glu Phe Glu Ala Leu Gly Leu Leu Ile Leu Leu 
            100                 105                 110         


Arg Leu Trp Arg Val Ala Arg Ile Ile Asn Gly Ile Ile Ile Ser Val 
        115                 120                 125             


Lys Thr Arg Ser Glu Arg Gln Leu Leu Arg Leu Lys Gln 
    130                 135                 140     


<210> 81
<211> 141
<212> PRT
<213> Macaca mulatta

<400> 81
Arg Lys Leu Phe Ser Ser His Arg Phe Gln Val Ile Ile Ile Cys Leu 
1               5                   10                  15      


Val Val Leu Asp Thr Leu Leu Val Leu Ala Glu Leu Ile Leu Asp Leu 
            20                  25                  30          


Arg Ile Ile Gln Pro Asp Lys Lys Asn Tyr Ala Ala Met Ile Phe His 
        35                  40                  45              


Tyr Met Ser Ile Ala Ile Leu Ala Leu Phe Met Met Glu Ile Thr Phe 
    50                  55                  60                  


Lys Leu Phe Val Phe Arg Leu Glu Phe Phe His His Lys Phe Glu Ile 
65                  70                  75                  80  


Leu Asp Ala Val Val Val Val Val Ser Phe Val Leu Asp Val Val Leu 
                85                  90                  95      


Leu Phe Gln Glu His Glu Phe Glu Ala Leu Gly Leu Leu Ile Leu Leu 
            100                 105                 110         


Arg Leu Trp Arg Val Ala Arg Ile Ile Asn Gly Ile Ile Ile Ser Val 
        115                 120                 125             


Lys Thr Arg Ser Glu Arg Gln Leu Leu Arg Leu Lys Gln 
    130                 135                 140     


<210> 82
<211> 141
<212> PRT
<213> Macaca mulatta

<400> 82
Arg Lys Leu Phe Ser Ser His Arg Phe Gln Val Ile Ile Ile Cys Leu 
1               5                   10                  15      


Val Val Leu Asp Thr Leu Leu Val Leu Ala Glu Leu Ile Leu Asp Leu 
            20                  25                  30          


Arg Ile Ile Gln Pro Asp Lys Lys Asn Tyr Ala Ala Met Ile Phe His 
        35                  40                  45              


Tyr Met Ser Ile Ala Ile Leu Ala Leu Phe Met Met Glu Ile Thr Phe 
    50                  55                  60                  


Lys Leu Phe Val Phe Arg Leu Glu Phe Phe His His Lys Phe Glu Ile 
65                  70                  75                  80  


Leu Asp Ala Val Val Val Val Val Ser Phe Val Leu Asp Val Val Leu 
                85                  90                  95      


Leu Phe Gln Glu His Glu Phe Glu Ala Leu Gly Leu Leu Ile Leu Leu 
            100                 105                 110         


Arg Leu Trp Arg Val Ala Arg Ile Ile Asn Gly Ile Ile Ile Ser Val 
        115                 120                 125             


Lys Thr Arg Ser Glu Arg Gln Leu Leu Arg Leu Lys Gln 
    130                 135                 140     


<210> 83
<211> 132
<212> PRT
<213> Macaca mulatta

<400> 83
Glu Val Ile Ile Ile Cys Leu Val Val Leu Asp Thr Leu Leu Val Leu 
1               5                   10                  15      


Ala Glu Leu Ile Leu Asp Leu Arg Ile Ile Gln Pro Asp Lys Lys Asn 
            20                  25                  30          


Tyr Ala Ala Met Ile Phe His Tyr Met Ser Ile Ala Ile Leu Ala Leu 
        35                  40                  45              


Phe Met Met Glu Ile Thr Phe Lys Leu Phe Val Phe Arg Leu Glu Phe 
    50                  55                  60                  


Phe His His Lys Phe Glu Ile Leu Asp Ala Val Val Val Val Val Ser 
65                  70                  75                  80  


Phe Val Leu Asp Val Val Leu Leu Phe Gln Glu His Glu Phe Glu Ala 
                85                  90                  95      


Leu Gly Leu Leu Ile Leu Leu Arg Leu Trp Arg Val Ala Arg Ile Ile 
            100                 105                 110         


Asn Gly Ile Ile Ile Ser Val Lys Thr Arg Ser Glu Arg Gln Leu Leu 
        115                 120                 125             


Arg Leu Lys Gln 
    130         


<210> 84
<211> 141
<212> PRT
<213> Canis lupus

<400> 84
Arg Lys Leu Phe Ser Ser His Arg Phe Gln Val Ile Ile Ile Cys Leu 
1               5                   10                  15      


Val Ile Leu Asp Ala Leu Leu Val Leu Ala Glu Leu Ile Leu Asp Leu 
            20                  25                  30          


Lys Ile Ile Gln Gly Asp Lys Asn Asn Tyr Ala Thr Lys Val Phe His 
        35                  40                  45              


Tyr Ser Ser Phe Ala Ile Leu Thr Leu Phe Met Met Glu Val Phe Leu 
    50                  55                  60                  


Lys Leu Phe Val Phe Arg Leu Glu Phe Phe His His Lys Phe Glu Ile 
65                  70                  75                  80  


Leu Asp Thr Phe Val Val Val Val Ser Phe Ile Leu Asp Leu Val Leu 
                85                  90                  95      


Leu Phe Gln Lys His Glu Phe Glu Ala Leu Gly Leu Leu Ile Leu Leu 
            100                 105                 110         


Arg Leu Trp Arg Val Ala Arg Ile Ile Asn Gly Ile Ile Ile Ser Val 
        115                 120                 125             


Lys Thr Arg Ser Glu Arg Gln Leu Leu Arg Leu Lys Gln 
    130                 135                 140     


<210> 85
<211> 141
<212> PRT
<213> Canis lupus

<400> 85
Arg Lys Leu Phe Ser Ser His Arg Phe Gln Val Ile Ile Ile Cys Leu 
1               5                   10                  15      


Val Ile Leu Asp Ala Leu Leu Val Leu Ala Glu Leu Ile Leu Asp Leu 
            20                  25                  30          


Lys Ile Ile Gln Gly Asp Lys Asn Asn Tyr Ala Thr Lys Val Phe His 
        35                  40                  45              


Tyr Ser Ser Phe Ala Ile Leu Thr Leu Phe Met Met Glu Val Phe Leu 
    50                  55                  60                  


Lys Leu Phe Val Phe Arg Leu Glu Phe Phe His His Lys Phe Glu Ile 
65                  70                  75                  80  


Leu Asp Thr Phe Val Val Val Val Ser Phe Ile Leu Asp Leu Val Leu 
                85                  90                  95      


Leu Phe Gln Lys His Glu Phe Glu Ala Leu Gly Leu Leu Ile Leu Leu 
            100                 105                 110         


Arg Leu Trp Arg Val Ala Arg Ile Ile Asn Gly Ile Ile Ile Ser Val 
        115                 120                 125             


Lys Thr Arg Ser Glu Arg Gln Leu Leu Arg Leu Lys Gln 
    130                 135                 140     


<210> 86
<211> 141
<212> PRT
<213> Mus musculus

<400> 86
Arg Lys Leu Phe Ser Ser His Arg Phe Gln Val Ile Ile Ile Cys Leu 
1               5                   10                  15      


Val Val Leu Asp Ala Leu Leu Val Leu Ala Glu Leu Leu Leu Asp Leu 
            20                  25                  30          


Lys Ile Ile Glu Pro Asp Glu Gln Asp Tyr Ala Val Thr Ala Phe His 
        35                  40                  45              


Tyr Met Ser Phe Ala Ile Leu Val Phe Phe Met Leu Glu Ile Phe Phe 
    50                  55                  60                  


Lys Ile Phe Val Phe Arg Leu Glu Phe Phe His His Lys Phe Glu Ile 
65                  70                  75                  80  


Leu Asp Ala Phe Val Val Val Val Ser Phe Val Leu Asp Leu Val Leu 
                85                  90                  95      


Leu Phe Lys Ser His His Phe Glu Ala Leu Gly Leu Leu Ile Leu Leu 
            100                 105                 110         


Arg Leu Trp Arg Val Ala Arg Ile Ile Asn Gly Ile Ile Ile Ser Val 
        115                 120                 125             


Lys Thr Arg Ser Glu Arg Gln Ile Leu Arg Leu Lys Gln 
    130                 135                 140     


<210> 87
<211> 141
<212> PRT
<213> Xenopus tropicalis

<400> 87
Lys Trp Leu Phe Ser Ser His Lys Phe Gln Ile Val Ile Ile Cys Leu 
1               5                   10                  15      


Val Ile Leu Asp Ala Leu Phe Val Leu Val Glu Val Leu Leu Asp Leu 
            20                  25                  30          


Glu Leu Leu Ala Glu Lys Val Asp His Ile Ile Pro Glu Ile Phe His 
        35                  40                  45              


Tyr Leu Ser Ile Ser Val Leu Ser Phe Phe Ile Leu Glu Ile Ala Gly 
    50                  55                  60                  


Lys Leu Tyr Ala Phe Arg Leu Glu Phe Phe His His Lys Phe Glu Val 
65                  70                  75                  80  


Phe Asp Ala Ala Ile Val Val Ile Ser Phe Ile Ile Asp Ile Val Tyr 
                85                  90                  95      


Ile Ser Arg Glu Asp Ile Phe Asn Ala Val Gly Leu Leu Ile Leu Leu 
            100                 105                 110         


Arg Leu Trp Arg Val Ala Arg Ile Val Asn Gly Ile Ile Val Ser Val 
        115                 120                 125             


Lys Thr Gln Ala Glu Asp Lys Ile His Arg Leu Lys Glu 
    130                 135                 140     


<210> 88
<211> 141
<212> PRT
<213> Xenopus laevis

<400> 88
Lys Trp Leu Leu Ser Ser His Lys Phe Gln Ile Val Ile Ile Cys Leu 
1               5                   10                  15      


Val Ile Leu Asp Ala Leu Phe Val Leu Val Glu Val Leu Leu Asp Leu 
            20                  25                  30          


Glu Leu Leu Ala Glu Lys Val Asp His Ile Ile Pro Glu Ile Phe His 
        35                  40                  45              


Tyr Leu Ser Ile Ser Val Leu Thr Phe Phe Ile Leu Glu Ile Ala Gly 
    50                  55                  60                  


Lys Leu Tyr Ala Phe Arg Leu Glu Phe Phe His His Lys Phe Glu Val 
65                  70                  75                  80  


Phe Asp Ala Ala Ile Val Val Ile Ser Phe Ile Ile Asp Ile Val Tyr 
                85                  90                  95      


Ile Ser Arg Glu Asp Ile Phe Asn Ala Val Gly Leu Leu Ile Leu Leu 
            100                 105                 110         


Arg Leu Trp Arg Val Ala Arg Ile Val Asn Gly Val Ile Val Ser Val 
        115                 120                 125             


Lys Thr Arg Ala Glu Glu Lys Met His Lys Leu Lys Glu 
    130                 135                 140     


<210> 89
<211> 141
<212> PRT
<213> Danio rerio

<400> 89
Arg Lys Leu Tyr Ser Thr Glu Arg Phe Gln Ile Val Val Val Cys Leu 
1               5                   10                  15      


Val Val Leu Asp Ala Ile Phe Val Leu Cys Glu Leu Leu Ile Asp Leu 
            20                  25                  30          


Ser Ile Ile Glu Ala Asp His His Arg Ile Ala Pro Gln Val Phe His 
        35                  40                  45              


Tyr Leu Ser Leu Ala Leu Leu Thr Phe Phe Met Val Glu Leu Ala Gly 
    50                  55                  60                  


Lys Ile Phe Ala Tyr Arg Leu Glu Phe Leu His His Lys Phe Glu Val 
65                  70                  75                  80  


Phe Asp Gly Ile Val Val Val Val Ser Phe Ile Leu Asp Ile Ile Tyr 
                85                  90                  95      


Ile Ser Lys Glu Asp Ala Phe Asp Ala Met Gly Leu Leu Ile Leu Leu 
            100                 105                 110         


Arg Leu Trp Arg Val Ala Arg Ile Ile Asn Gly Ile Leu Val Ser Val 
        115                 120                 125             


Gln Asn Arg Ala Asn His Arg Val Glu Lys Leu Lys Glu 
    130                 135                 140     


<210> 90
<211> 141
<212> PRT
<213> Tetraodon nigroviridis

<400> 90
Lys Gln Met Tyr Cys Ser Glu Arg Phe Gln Ile Leu Val Val Cys Leu 
1               5                   10                  15      


Val Ile Leu Asp Ala Ile Phe Val Leu Val Glu Leu Leu Leu Asp Leu 
            20                  25                  30          


Ser Ile Ile Lys Leu Asp His Gly Ser Val Ala Pro Glu Val Phe His 
        35                  40                  45              


Phe Leu Ser Leu Gly Leu Val Val Phe Phe Leu Leu Glu Leu Ala Gly 
    50                  55                  60                  


Lys Leu Phe Ala Phe Arg Lys Glu Phe Phe Asp His Lys Phe Glu Val 
65                  70                  75                  80  


Phe Asp Gly Leu Val Val Thr Val Ser Phe Val Leu Asp Val Ala Phe 
                85                  90                  95      


Ile Phe His Glu Asp Ala Phe Asp Gly Ile Gly Leu Leu Ile Leu Leu 
            100                 105                 110         


Arg Leu Trp Arg Val Ala Arg Ile Ile Asn Gly Ile Leu Val Ser Val 
        115                 120                 125             


Lys Thr Arg Glu Gln Gln Lys Leu His Lys Leu Lys Glu 
    130                 135                 140     


<210> 91
<211> 141
<212> PRT
<213> Takifugu sp.

<400> 91
Lys Trp Leu Tyr Cys Ser Asp Arg Phe Gln Val Leu Val Val Cys Leu 
1               5                   10                  15      


Val Ile Leu Asp Ala Ile Phe Val Leu Val Glu Leu Leu Leu Asp Leu 
            20                  25                  30          


Ser Ile Ile Lys Leu Asp His Gly Asn Val Ile Pro Glu Val Phe His 
        35                  40                  45              


Tyr Leu Ser Leu Ala Leu Val Thr Phe Phe Val Val Glu Leu Val Gly 
    50                  55                  60                  


Lys Leu Phe Ala Phe Arg Lys Glu Phe Phe Asp His Lys Phe Glu Val 
65                  70                  75                  80  


Phe Asp Gly Leu Val Val Val Val Ser Phe Val Leu Asp Val Ala Phe 
                85                  90                  95      


Ile Phe Arg Glu Asp Ala Phe Asp Gly Ile Gly Leu Leu Ile Leu Leu 
            100                 105                 110         


Arg Leu Trp Arg Val Ala Arg Ile Ile Asn Gly Ile Leu Val Ser Val 
        115                 120                 125             


Lys Thr Arg Glu Gln Gln Lys Leu His Lys Leu Lys Glu 
    130                 135                 140     


<210> 92
<211> 140
<212> PRT
<213> Nematostella vectensis

<400> 92
Cys Glu Ile Ile His Gly Gln Lys Ala Gln Tyr Thr Ile Ile Ala Leu 
1               5                   10                  15      


Val Ile Ile Asp Cys Ile Ile Val Ile Ala Glu Leu Leu Val Asp Leu 
            20                  25                  30          


Glu Ile Leu Lys Val His His Asp Asn Pro Ala Pro His Ile Leu His 
        35                  40                  45              


Asp Val Ser Ile Ala Ile Leu Ser Leu Phe Ile Ile Glu Leu Ile Val 
    50                  55                  60                  


Lys Ile Tyr Ala Met Gly Met Glu Phe Phe His His Lys Leu Glu Val 
65                  70                  75                  80  


Phe Asp Gly Ile Val Val Ile Val Ser Phe Ala Leu Asp Ile Ala Phe 
                85                  90                  95      


Ser Gly Gly Asn Ala Ala Glu Gly Ala Ser Leu Leu Ile Ile Leu Arg 
            100                 105                 110         


Leu Trp Arg Val Thr Arg Ile Val Asn Gly Ile Ile Leu Ser Val Lys 
        115                 120                 125             


Met Gln Asp Glu Lys Lys Ile His His Leu His Lys 
    130                 135                 140 


<210> 93
<211> 143
<212> PRT
<213> Ciona intestinalis

<400> 93
Arg His Ile Leu His Ser Lys Pro Ile His Val Ala Ile Ile Val Leu 
1               5                   10                  15      


Val Val Leu Asp Ser Phe Leu Val Val Gly Glu Leu Leu Ile Asp Leu 
            20                  25                  30          


Lys Val Ile Ile Val Pro His Gly Asn Pro Ala Pro Glu Ile Leu His 
        35                  40                  45              


Gly Phe Ser Leu Ser Ile Leu Ser Ile Phe Met Val Glu Ile Ala Leu 
    50                  55                  60                  


Lys Ile Ile Ala Asp His Arg His Phe Ile His His Lys Val Glu Val 
65                  70                  75                  80  


Leu Asp Ala Val Val Val Val Ile Ser Phe Gly Val Asp Ile Ala Leu 
                85                  90                  95      


Ile Phe Val Gly Glu Ser Glu Ala Leu Ala Ala Ile Gly Leu Leu Val 
            100                 105                 110         


Ile Leu Arg Leu Trp Arg Val Phe Arg Ile Ile Asn Gly Ile Ile Val 
        115                 120                 125             


Thr Val Lys Thr Lys Ala Asp Asp Arg Val His Glu Ile Lys Lys 
    130                 135                 140             


<210> 94
<211> 138
<212> PRT
<213> Trichoplax adhaerens

<400> 94
Arg Gln Leu Ile Tyr Ser His Lys Val His Ile Ala Ile Val Val Leu 
1               5                   10                  15      


Val Ile Leu Asp Ala Leu Ile Val Ile Ala Glu Leu Leu Ile Asp Leu 
            20                  25                  30          


Ser Val Ile Lys Val His His Thr Ser Pro Leu Ala Arg Ala Phe His 
        35                  40                  45              


Phe Thr Ser Ile Ala Ile Leu Ala Ile Phe Leu Val Glu Ile Val Leu 
    50                  55                  60                  


Lys Leu Tyr Ala Ser Asp Leu Ala Phe Phe Leu His Tyr Phe Glu Val 
65                  70                  75                  80  


Phe Asp Ala Leu Ile Val Ile Val Ser Phe Val Leu Asp Ile Ala Tyr 
                85                  90                  95      


Ser Asn Ser Glu Ala Leu Ser Gly Val Gly Leu Leu Val Val Leu Arg 
            100                 105                 110         


Leu Trp Arg Ile Ala Arg Ile Val Asn Gly Ile Ile Ser Ser Val Lys 
        115                 120                 125             


Ser Gln Ala Asn Asp Lys Ile His His Leu 
    130                 135             


<210> 95
<211> 142
<212> PRT
<213> Homo sapiens

<400> 95
His Tyr Ile Val Asn Leu Arg Tyr Phe Glu Met Cys Ile Leu Leu Val 
1               5                   10                  15      


Ile Ala Ala Ser Ser Ile Ala Leu Ala Ala Glu Asp Pro Val Leu Thr 
            20                  25                  30          


Asn Ser Glu Arg Asn Lys Val Leu Arg Tyr Phe Asp Tyr Val Phe Thr 
        35                  40                  45              


Gly Val Phe Thr Phe Glu Met Val Ile Lys Met Ile Asp Gln Gly Leu 
    50                  55                  60                  


Ile Leu Gln Asp Gly Ser Tyr Phe Arg Asp Leu Trp Asn Ile Leu Asp 
65                  70                  75                  80  


Phe Val Val Val Val Gly Ala Leu Val Ala Phe Ala Leu Ala Asn Ala 
                85                  90                  95      


Leu Gly Thr Asn Lys Gly Arg Asp Ile Lys Thr Ile Lys Ser Leu Arg 
            100                 105                 110         


Val Leu Arg Val Leu Arg Pro Leu Lys Thr Ile Lys Arg Leu Pro Lys 
        115                 120                 125             


Leu Lys Ala Val Phe Asp Cys Val Val Thr Ser Leu Lys Asn 
    130                 135                 140         


<210> 96
<211> 141
<212> PRT
<213> Drosophila melanogaster

<400> 96
His Trp Val Val Asn Leu Pro Tyr Phe Asp Phe Phe Ile Met Val Val 
1               5                   10                  15      


Ile Ser Met Ser Ser Ile Ala Leu Ala Ala Glu Asp Pro Val Arg Glu 
            20                  25                  30          


Asn Ser Arg Arg Asn Lys Ile Leu Asn Tyr Phe Asp Tyr Ala Phe Thr 
        35                  40                  45              


Gly Val Phe Thr Ile Glu Met Leu Leu Lys Ile Val Asp Leu Gly Val 
    50                  55                  60                  


Ile Leu His Pro Gly Ser Tyr Leu Arg Glu Phe Trp Asn Ile Met Asp 
65                  70                  75                  80  


Ala Val Val Val Ile Cys Ala Ala Val Ser Phe Gly Phe Asp Met Ser 
                85                  90                  95      


Gly Ser Ser Ala Gly Gln Asn Leu Ser Thr Ile Lys Ser Leu Arg Val 
            100                 105                 110         


Leu Arg Val Leu Arg Pro Leu Lys Thr Ile Lys Arg Val Pro Lys Leu 
        115                 120                 125             


Lys Ala Val Phe Asp Cys Val Val Asn Ser Leu Lys Asn 
    130                 135                 140     


<210> 97
<211> 136
<212> PRT
<213> Mus musculus

<400> 97
Leu Arg Leu Val Cys Asn Pro Trp Phe Glu His Ile Ser Met Leu Val 
1               5                   10                  15      


Ile Met Leu Asn Cys Val Thr Leu Gly Met Phe Arg Pro Cys Glu Asp 
            20                  25                  30          


Val Glu Cys Arg Ser Glu Arg Cys Ser Ile Leu Glu Ala Phe Asp Asp 
        35                  40                  45              


Phe Ile Phe Ala Phe Phe Ala Val Glu Met Val Ile Lys Met Val Ala 
    50                  55                  60                  


Leu Gly Leu Phe Gly Gln Lys Cys Tyr Leu Gly Asp Thr Trp Asn Arg 
65                  70                  75                  80  


Leu Asp Phe Phe Ile Val Met Ala Gly Met Met Glu Tyr Ser Leu Asp 
                85                  90                  95      


Gly His Asn Val Ser Leu Ser Ala Ile Arg Thr Val Arg Val Leu Arg 
            100                 105                 110         


Pro Leu Arg Ala Ile Asn Arg Val Pro Ser Met Arg Ile Leu Val Thr 
        115                 120                 125             


Leu Leu Leu Asp Thr Leu Pro Met 
    130                 135     


<210> 98
<211> 136
<212> PRT
<213> Homo sapiens

<400> 98
Ile Lys Met Val Cys Asn Pro Trp Phe Glu Cys Val Ser Met Leu Val 
1               5                   10                  15      


Ile Leu Leu Asn Cys Val Thr Leu Gly Met Tyr Gln Pro Cys Asp Asp 
            20                  25                  30          


Met Asp Cys Leu Ser Asp Arg Cys Lys Ile Leu Gln Val Phe Asp Asp 
        35                  40                  45              


Phe Ile Phe Ile Phe Phe Ala Met Glu Met Val Leu Lys Met Val Ala 
    50                  55                  60                  


Leu Gly Ile Phe Gly Lys Lys Cys Tyr Leu Gly Asp Thr Trp Asn Arg 
65                  70                  75                  80  


Leu Asp Phe Phe Ile Val Met Ala Gly Met Val Glu Tyr Ser Leu Asp 
                85                  90                  95      


Leu Gln Asn Ile Asn Leu Ser Ala Ile Arg Thr Val Arg Val Leu Arg 
            100                 105                 110         


Pro Leu Lys Ala Ile Asn Arg Val Pro Ser Met Arg Ile Leu Val Asn 
        115                 120                 125             


Leu Leu Leu Asp Thr Leu Pro Met 
    130                 135     


<210> 99
<211> 142
<212> PRT
<213> Homo sapiens

<400> 99
His Arg Ile Ile Thr His Lys Met Phe Asp His Val Val Leu Val Ile 
1               5                   10                  15      


Ile Phe Leu Asn Cys Ile Thr Ile Ala Met Glu Arg Pro Lys Ile Asp 
            20                  25                  30          


Pro His Ser Ala Glu Arg Ile Phe Leu Thr Leu Ser Asn Tyr Ile Phe 
        35                  40                  45              


Thr Ala Val Phe Leu Ala Glu Met Thr Val Lys Val Val Ala Leu Gly 
    50                  55                  60                  


Trp Cys Phe Gly Glu Gln Ala Tyr Leu Arg Ser Ser Trp Asn Val Leu 
65                  70                  75                  80  


Asp Gly Leu Leu Val Leu Ile Ser Val Ile Asp Ile Leu Val Ser Met 
                85                  90                  95      


Val Ser Asp Ser Gly Thr Lys Ile Leu Gly Met Leu Arg Val Leu Arg 
            100                 105                 110         


Leu Leu Arg Thr Leu Arg Pro Leu Arg Val Ile Ser Arg Ala Gln Gly 
        115                 120                 125             


Leu Lys Leu Val Val Glu Thr Leu Met Ser Ser Leu Lys Pro 
    130                 135                 140         


<210> 100
<211> 125
<212> PRT
<213> Gallus gallus

<400> 100
Ile Lys Ile Leu Val His Ser Leu Phe Ser Met Leu Ile Met Cys Thr 
1               5                   10                  15      


Ile Leu Thr Asn Cys Val Phe Met Thr Met Ser Asn Pro Pro Asp Trp 
            20                  25                  30          


Thr Lys Asn Val Glu Tyr Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser 
        35                  40                  45              


Leu Ile Lys Ile Leu Ala Arg Gly Phe Cys Leu Glu Asp Phe Thr Phe 
    50                  55                  60                  


Leu Arg Asp Pro Trp Asn Trp Leu Asp Phe Thr Val Ile Thr Phe Ala 
65                  70                  75                  80  


Tyr Val Thr Glu Phe Val Asn Leu Gly Asn Val Ser Ala Leu Arg Thr 
                85                  90                  95      


Phe Arg Val Leu Arg Ala Leu Lys Thr Ile Ser Val Ile Pro Gly Leu 
            100                 105                 110         


Lys Thr Ile Val Gly Ala Leu Ile Gln Ser Val Lys Lys 
        115                 120                 125 


<210> 101
<211> 125
<212> PRT
<213> Rattus norvegicus

<400> 101
Ile Lys Ile Leu Val His Ser Leu Phe Asn Val Leu Ile Met Cys Thr 
1               5                   10                  15      


Ile Leu Thr Asn Cys Val Phe Met Thr Met Ser Asn Pro Pro Asp Trp 
            20                  25                  30          


Thr Lys Asn Val Glu Tyr Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser 
        35                  40                  45              


Leu Ile Lys Ile Leu Ala Arg Gly Phe Cys Leu Glu Asp Phe Thr Phe 
    50                  55                  60                  


Leu Arg Asn Pro Trp Asn Trp Leu Asp Phe Thr Val Ile Thr Phe Ala 
65                  70                  75                  80  


Tyr Val Thr Glu Phe Val Asn Leu Gly Asn Val Ser Ala Leu Arg Thr 
                85                  90                  95      


Phe Arg Val Leu Arg Ala Leu Lys Thr Ile Ser Val Ile Pro Gly Leu 
            100                 105                 110         


Lys Thr Ile Val Gly Ala Leu Ile Gln Ser Val Lys Lys 
        115                 120                 125 


<210> 102
<211> 125
<212> PRT
<213> Mus musculus

<400> 102
Ile Lys Ile Leu Val His Ser Leu Phe Ser Met Leu Ile Met Cys Thr 
1               5                   10                  15      


Ile Leu Thr Asn Cys Val Phe Met Thr Met Ser Asn Pro Pro Asp Trp 
            20                  25                  30          


Thr Lys Asn Val Glu Tyr Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser 
        35                  40                  45              


Leu Ile Lys Ile Leu Ala Arg Gly Phe Cys Leu Glu Asp Phe Thr Phe 
    50                  55                  60                  


Leu Arg Asp Pro Trp Asn Trp Leu Asp Phe Thr Val Ile Thr Phe Ala 
65                  70                  75                  80  


Tyr Val Thr Glu Phe Val Asp Leu Gly Asn Val Ser Ala Leu Arg Thr 
                85                  90                  95      


Phe Arg Val Leu Arg Ala Leu Lys Thr Ile Ser Val Ile Pro Gly Leu 
            100                 105                 110         


Lys Thr Ile Val Gly Ala Leu Ile Gln Ser Val Lys Lys 
        115                 120                 125 


<210> 103
<211> 125
<212> PRT
<213> Mus musculus

<400> 103
Ile Lys Ile Leu Val His Ser Leu Phe Asn Val Leu Ile Met Cys Thr 
1               5                   10                  15      


Ile Leu Thr Asn Cys Val Phe Met Thr Met Ser Asn Pro Pro Asp Trp 
            20                  25                  30          


Thr Lys Asn Val Glu Tyr Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser 
        35                  40                  45              


Leu Ile Lys Ile Leu Ala Arg Gly Phe Cys Leu Glu Asp Phe Thr Phe 
    50                  55                  60                  


Leu Arg Asp Pro Trp Asn Trp Leu Asp Phe Thr Val Ile Thr Phe Ala 
65                  70                  75                  80  


Tyr Val Thr Glu Phe Val Asn Leu Gly Asn Val Ser Ala Leu Arg Thr 
                85                  90                  95      


Phe Arg Val Leu Arg Ala Leu Lys Thr Ile Ser Val Ile Pro Gly Leu 
            100                 105                 110         


Lys Thr Ile Val Gly Ala Leu Ile Gln Ser Val Lys Lys 
        115                 120                 125 


<210> 104
<211> 127
<212> PRT
<213> Rattus norvegicus

<400> 104
Ile Arg Ile Ser Val His Ser Val Phe Ser Met Phe Ile Ile Cys Thr 
1               5                   10                  15      


Val Ile Ile Asn Cys Met Phe Met Ala Asn Ser Met Glu Arg Ser Phe 
            20                  25                  30          


Asp Asn Asp Ile Pro Glu Tyr Val Phe Ile Gly Ile Tyr Ile Leu Glu 
        35                  40                  45              


Ala Val Ile Lys Ile Leu Ala Arg Gly Phe Ile Val Asp Glu Phe Ser 
    50                  55                  60                  


Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp Phe Ile Val Ile Gly Thr 
65                  70                  75                  80  


Ala Ile Ala Thr Cys Phe Pro Gly Ser Gln Val Asn Leu Ser Ala Leu 
                85                  90                  95      


Arg Thr Phe Arg Val Phe Arg Ala Leu Lys Ala Ile Ser Val Ile Ser 
            100                 105                 110         


Gly Leu Lys Val Ile Val Gly Ala Leu Leu Arg Ser Val Lys Lys 
        115                 120                 125         


<210> 105
<211> 130
<212> PRT
<213> Mus musculus

<400> 105
Ile Arg Ile Ser Val His Ser Val Phe Ser Met Phe Ile Ile Cys Thr 
1               5                   10                  15      


Val Ile Ile Asn Cys Met Phe Met Ala Asn Asn Ser Ser Val Asp Ser 
            20                  25                  30          


Arg Pro Ser Ser Asn Ile Pro Glu Tyr Val Phe Ile Gly Ile Tyr Val 
        35                  40                  45              


Leu Glu Ala Val Ile Lys Ile Leu Ala Arg Gly Phe Ile Val Asp Glu 
    50                  55                  60                  


Phe Ser Tyr Leu Arg Asp Pro Trp Asn Trp Leu Asp Phe Ile Val Ile 
65                  70                  75                  80  


Gly Thr Ala Ile Ala Pro Cys Phe Leu Gly Asn Lys Val Asn Asn Leu 
                85                  90                  95      


Ser Thr Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Ala Ile Ser 
            100                 105                 110         


Val Ile Ser Gly Leu Lys Val Ile Val Gly Ala Leu Leu Arg Ser Val 
        115                 120                 125             


Lys Lys 
    130 


<210> 106
<211> 130
<212> PRT
<213> Homo sapiens

<400> 106
Ile Arg Val Ser Val His Ser Leu Phe Ser Met Phe Ile Ile Gly Thr 
1               5                   10                  15      


Val Ile Ile Asn Cys Val Phe Met Ala Thr Gly Pro Ala Lys Asn Ser 
            20                  25                  30          


Asn Ser Asn Asn Thr Asp Ile Ala Glu Cys Val Phe Thr Gly Ile Tyr 
        35                  40                  45              


Ile Phe Glu Ala Leu Ile Lys Ile Leu Ala Arg Gly Phe Ile Leu Asp 
    50                  55                  60                  


Glu Phe Ser Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp Ser Ile Val 
65                  70                  75                  80  


Ile Gly Ile Ala Ile Val Ser Tyr Ile Pro Gly Ile Thr Ile Lys Leu 
                85                  90                  95      


Leu Pro Leu Arg Thr Phe Arg Val Phe Arg Ala Leu Lys Ala Ile Ser 
            100                 105                 110         


Val Val Ser Arg Leu Lys Val Ile Val Gly Ala Leu Leu Arg Ser Val 
        115                 120                 125             


Lys Lys 
    130 


<210> 107
<211> 125
<212> PRT
<213> Taeniopygia guttata

<400> 107
Ile Lys Ile Leu Val His Ser Leu Phe Ser Met Phe Ile Met Cys Thr 
1               5                   10                  15      


Ile Leu Thr Asn Cys Val Phe Met Ala Gln Ser Glu Thr Pro Ser Trp 
            20                  25                  30          


Asn Lys Tyr Val Glu Tyr Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser 
        35                  40                  45              


Leu Ile Lys Ile Leu Ala Arg Gly Phe Cys Met Thr Glu Phe Thr Phe 
    50                  55                  60                  


Leu Arg Asp Pro Trp Asn Trp Leu Asp Phe Ser Val Ile Val Met Ala 
65                  70                  75                  80  


Tyr Ile Thr Glu Phe Val Asp Leu Gly Asn Val Ser Ala Leu Arg Thr 
                85                  90                  95      


Phe Arg Val Leu Arg Ala Leu Lys Thr Ile Ser Val Ile Ser Gly Leu 
            100                 105                 110         


Lys Thr Ile Val Gly Ala Leu Ile Gln Ser Val Lys Lys 
        115                 120                 125 


<210> 108
<211> 125
<212> PRT
<213> Rattus norvegicus

<400> 108
Val Lys Ile Leu Val His Ser Leu Phe Ser Met Leu Ile Met Cys Thr 
1               5                   10                  15      


Ile Leu Thr Asn Cys Val Phe Met Ala Gln His Asp Pro Pro Pro Trp 
            20                  25                  30          


Thr Lys Tyr Val Glu Tyr Thr Phe Thr Ala Ile Tyr Thr Phe Glu Ser 
        35                  40                  45              


Leu Val Lys Ile Leu Ala Arg Gly Phe Cys Leu His Ala Phe Thr Phe 
    50                  55                  60                  


Leu Arg Asp Pro Trp Asn Trp Leu Asp Phe Ser Val Ile Val Met Ala 
65                  70                  75                  80  


Tyr Thr Thr Glu Phe Val Asp Leu Gly Asn Val Ser Ala Leu Arg Thr 
                85                  90                  95      


Phe Arg Val Leu Arg Ala Leu Lys Thr Ile Ser Val Ile Ser Gly Leu 
            100                 105                 110         


Lys Thr Ile Val Gly Ala Leu Ile Gln Ser Val Lys Lys 
        115                 120                 125 


<210> 109
<211> 125
<212> PRT
<213> Rattus norvegicus

<400> 109
Ile Lys Ile Leu Val His Ser Leu Phe Ser Met Leu Ile Met Cys Thr 
1               5                   10                  15      


Ile Leu Thr Asn Cys Ile Phe Met Thr Leu Ser Asn Pro Pro Glu Trp 
            20                  25                  30          


Thr Lys Asn Val Glu Tyr Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser 
        35                  40                  45              


Leu Ile Lys Ile Leu Ala Arg Gly Phe Cys Val Gly Glu Phe Thr Phe 
    50                  55                  60                  


Leu Arg Asp Pro Trp Asn Trp Leu Asp Phe Val Val Ile Val Phe Ala 
65                  70                  75                  80  


Tyr Leu Thr Glu Phe Val Asn Leu Gly Asn Val Ser Ala Leu Arg Thr 
                85                  90                  95      


Phe Arg Val Leu Arg Ala Leu Lys Thr Ile Ser Val Ile Pro Gly Leu 
            100                 105                 110         


Lys Thr Ile Val Gly Ala Leu Ile Gln Ser Val Lys Lys 
        115                 120                 125 


<210> 110
<211> 125
<212> PRT
<213> Oryctolagus cuniculus

<400> 110
Ile Lys Ile Leu Val His Ser Leu Phe Ser Met Leu Ile Met Cys Thr 
1               5                   10                  15      


Ile Leu Thr Asn Cys Ile Phe Met Thr Met Asn Asn Pro Ala Glu Trp 
            20                  25                  30          


Thr Lys Asn Val Glu Tyr Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser 
        35                  40                  45              


Leu Val Lys Ile Phe Ala Arg Gly Phe Cys Val Gly Glu Phe Thr Phe 
    50                  55                  60                  


Leu Arg Asp Pro Trp Asn Trp Leu Asp Phe Ile Val Ile Val Phe Ala 
65                  70                  75                  80  


Tyr Leu Thr Glu Phe Val Asn Leu Gly Asn Val Ser Ala Leu Arg Thr 
                85                  90                  95      


Phe Arg Val Leu Arg Ala Leu Lys Thr Ile Ser Val Ile Pro Gly Leu 
            100                 105                 110         


Lys Thr Ile Val Gly Ala Leu Ile Gln Ser Val Lys Lys 
        115                 120                 125 


<210> 111
<211> 125
<212> PRT
<213> Homo sapiens

<400> 111
Ile Lys Ile Leu Val His Ser Leu Phe Ser Met Leu Ile Met Cys Thr 
1               5                   10                  15      


Ile Leu Thr Asn Cys Val Phe Met Thr Leu Ser Asn Pro Pro Asp Trp 
            20                  25                  30          


Thr Lys Asn Val Glu Tyr Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser 
        35                  40                  45              


Leu Ile Lys Ile Leu Ala Arg Gly Phe Cys Leu Glu Asp Phe Thr Phe 
    50                  55                  60                  


Leu Arg Asp Pro Trp Asn Trp Leu Asp Phe Ser Val Ile Val Met Ala 
65                  70                  75                  80  


Tyr Val Thr Glu Phe Val Ser Leu Gly Asn Val Ser Ala Leu Arg Thr 
                85                  90                  95      


Phe Arg Val Leu Arg Ala Leu Lys Thr Ile Ser Val Ile Pro Gly Leu 
            100                 105                 110         


Lys Thr Ile Val Gly Ala Leu Ile Gln Ser Val Lys Lys 
        115                 120                 125 


<210> 112
<211> 118
<212> PRT
<213> Canis lupus

<400> 112
Ile Lys Ile Leu Val His Ser Leu Phe Asn Val Leu Ile Met Cys Thr 
1               5                   10                  15      


Ile Leu Thr Asn Cys Val Phe Met Thr Met Ser Asn Pro Pro Asp Trp 
            20                  25                  30          


Thr Lys Asn Val Glu Tyr Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser 
        35                  40                  45              


Leu Ile Lys Ile Leu Ala Arg Gly Phe Cys Leu Glu Asp Phe Thr Phe 
    50                  55                  60                  


Leu Arg Asp Pro Trp Asn Trp Leu Asp Phe Thr Val Ile Thr Phe Ala 
65                  70                  75                  80  


Tyr Val Thr Glu Phe Val Asp Leu Gly Asn Val Ser Ala Leu Arg Thr 
                85                  90                  95      


Phe Arg Val Leu Arg Ala Leu Lys Thr Ile Ser Val Ile Pro Gly Leu 
            100                 105                 110         


Lys Thr Ile Val Gly Ala 
        115             


<210> 113
<211> 125
<212> PRT
<213> Danio rerio

<400> 113
Ile Lys Ile Leu Ile His Ser Val Phe Ser Met Phe Ile Met Cys Thr 
1               5                   10                  15      


Ile Leu Thr Asn Cys Val Phe Met Thr Phe Ser Asn Pro Pro Glu Trp 
            20                  25                  30          


Ser Lys Gln Val Glu Tyr Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser 
        35                  40                  45              


Ala Val Lys Ile Ile Ala Arg Gly Phe Cys Ile Asp Gly Phe Thr Phe 
    50                  55                  60                  


Leu Arg Asp Pro Trp Asn Trp Leu Asp Phe Met Val Ile Ser Met Ala 
65                  70                  75                  80  


Tyr Val Thr Glu Phe Val Asp Leu Gly Asn Val Ser Ala Leu Arg Thr 
                85                  90                  95      


Phe Arg Val Leu Arg Ala Leu Lys Thr Ile Ser Val Ile Pro Gly Leu 
            100                 105                 110         


Lys Thr Ile Val Gly Ala Leu Ile Gln Ser Val Lys Lys 
        115                 120                 125 


<210> 114
<211> 125
<212> PRT
<213> Mus musculus

<400> 114
Ile Lys Ile Leu Ile His Ser Val Phe Ser Met Ile Ile Met Cys Thr 
1               5                   10                  15      


Ile Leu Thr Asn Cys Val Phe Met Thr Phe Ser Asn Pro Pro Glu Trp 
            20                  25                  30          


Ser Lys Asn Val Glu Tyr Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser 
        35                  40                  45              


Leu Val Lys Ile Ile Ala Arg Gly Phe Cys Ile Asp Gly Phe Thr Phe 
    50                  55                  60                  


Leu Arg Asp Pro Trp Asn Trp Leu Asp Phe Ser Val Ile Met Met Ala 
65                  70                  75                  80  


Tyr Val Thr Glu Phe Val Asp Leu Gly Asn Val Ser Ala Leu Arg Thr 
                85                  90                  95      


Phe Arg Val Leu Arg Ala Leu Lys Thr Ile Ser Val Ile Pro Gly Leu 
            100                 105                 110         


Lys Thr Ile Val Gly Ala Leu Ile Gln Ser Val Lys Lys 
        115                 120                 125 


<210> 115
<211> 122
<212> PRT
<213> Canis lupus

<400> 115
Ile Lys Val Ser Val His Ser Trp Phe Ser Leu Phe Ile Thr Val Thr 
1               5                   10                  15      


Ile Leu Val Asn Cys Val Gly Met Thr Gln Thr Glu Leu Pro Asp Arg 
            20                  25                  30          


Ile Glu Tyr Val Phe Thr Val Ile Tyr Thr Phe Glu Ala Leu Ile Lys 
        35                  40                  45              


Ile Leu Ala Arg Gly Phe Cys Leu Asn Glu Phe Ala Tyr Leu Arg Asp 
    50                  55                  60                  


Pro Trp Asp Trp Leu Asp Phe Ser Val Ile Thr Leu Ala Tyr Ile Gly 
65                  70                  75                  80  


Glu Ala Thr Ala Leu Arg Gly Ile Ser Gly Leu Arg Thr Phe Arg Val 
                85                  90                  95      


Leu Arg Ala Leu Lys Thr Val Ser Val Ile Pro Gly Leu Lys Val Ile 
            100                 105                 110         


Val Gly Ala Leu Ile His Ser Val Arg Lys 
        115                 120         


<210> 116
<211> 125
<212> PRT
<213> Homo sapiens

<400> 116
Ile Lys Val Leu Val His Pro Phe Phe Gln Leu Phe Ile Leu Ile Ser 
1               5                   10                  15      


Val Leu Ile Asp Cys Val Phe Met Ser Leu Thr Asn Leu Pro Lys Trp 
            20                  25                  30          


Arg Pro Val Leu Glu Asn Thr Leu Leu Gly Ile Tyr Thr Phe Glu Ile 
        35                  40                  45              


Leu Val Lys Leu Phe Ala Arg Gly Val Trp Ala Gly Ser Phe Ser Phe 
    50                  55                  60                  


Leu Gly Asp Pro Trp Asn Trp Leu Asp Phe Ser Val Thr Val Phe Glu 
65                  70                  75                  80  


Val Ile Ile Arg Tyr Ser Pro Leu Asp Phe Ile Pro Thr Leu Gln Thr 
                85                  90                  95      


Ala Arg Thr Leu Arg Ile Leu Lys Ile Ile Pro Leu Asn Gln Gly Leu 
            100                 105                 110         


Lys Ser Leu Val Gly Val Leu Ile His Cys Leu Lys Gln 
        115                 120                 125 


<210> 117
<211> 149
<212> PRT
<213> Oryctolagus cuniculus

<400> 117
Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile Ile Ile Leu Leu Thr 
1               5                   10                  15      


Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr Ile Pro Phe Pro Glu 
            20                  25                  30          


Asp Asp Ser Asn Ala Thr Asn Ser Asn Leu Glu Arg Val Glu Tyr Leu 
        35                  40                  45              


Phe Leu Ile Ile Phe Thr Val Glu Ala Phe Leu Lys Val Ile Ala Tyr 
    50                  55                  60                  


Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg Asn Gly Trp Asn Leu 
65                  70                  75                  80  


Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe Ser Ala Ile Leu Glu 
                85                  90                  95      


Gln Ala Thr Lys Ala Asp Gly Ala Asn Ala Leu Gly Gly Lys Gly Ala 
            100                 105                 110         


Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg Val Leu Arg Pro Leu 
        115                 120                 125             


Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val Val Leu Asn Ser Ile 
    130                 135                 140                 


Ile Lys Ala Met Val 
145                 


<210> 118
<211> 150
<212> PRT
<213> Mus musculus

<400> 118
Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Thr Ile Ile Leu Leu Thr 
1               5                   10                  15      


Ile Phe Ala Asn Cys Val Ala Leu Ala Val Tyr Leu Pro Met Pro Glu 
            20                  25                  30          


Asp Asp Asn Asn Thr Leu Asn Leu Gly Leu Glu Lys Leu Glu Tyr Phe 
        35                  40                  45              


Phe Leu Ile Val Phe Ser Ile Glu Ala Ala Met Lys Ile Ile Ala Tyr 
    50                  55                  60                  


Gly Phe Leu Phe His Gln Asp Ala Tyr Leu Arg Ser Gly Trp Asn Val 
65                  70                  75                  80  


Leu Asp Phe Ile Ile Val Phe Leu Gly Val Phe Thr Val Ile Leu Glu 
                85                  90                  95      


Gln Val Asn Ile Ile Gln Thr Asn Thr Ala Pro Met Ser Ser Lys Gly 
            100                 105                 110         


Ala Gly Leu Asp Val Lys Ala Leu Arg Ala Phe Arg Val Leu Arg Pro 
        115                 120                 125             


Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val Val Leu Asn Ser 
    130                 135                 140                 


Ile Phe Lys Ala Met Leu 
145                 150 


<210> 119
<211> 150
<212> PRT
<213> Mus musculus

<400> 119
Ile Ser Ile Val Glu Trp Lys Pro Phe Asp Ile Leu Ile Leu Leu Thr 
1               5                   10                  15      


Ile Phe Ala Asn Cys Val Ala Leu Gly Val Tyr Ile Pro Phe Pro Glu 
            20                  25                  30          


Asp Asp Ser Asn Thr Ala Asn His Asn Leu Glu Gln Val Glu Tyr Val 
        35                  40                  45              


Phe Leu Val Ile Phe Thr Val Glu Thr Val Leu Lys Ile Val Ala Tyr 
    50                  55                  60                  


Gly Leu Val Leu His Pro Ser Ala Tyr Ile Arg Asn Gly Trp Asn Leu 
65                  70                  75                  80  


Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe Ser Val Leu Leu Glu 
                85                  90                  95      


Gln Gly Pro Gly Arg Pro Gly Asp Ala Pro His Thr Gly Gly Lys Pro 
            100                 105                 110         


Gly Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg Val Leu Arg Pro 
        115                 120                 125             


Leu Arg Leu Val Ser Gly Val Pro Ser Leu His Ile Val Val Asn Ser 
    130                 135                 140                 


Ile Met Lys Ala Leu Val 
145                 150 


<210> 120
<211> 150
<212> PRT
<213> Gallus gallus

<400> 120
Ile Ser Leu Val Glu Trp Lys Pro Phe Asp Ile Phe Ile Leu Leu Ser 
1               5                   10                  15      


Ile Phe Ala Asn Cys Val Ala Leu Ala Val Tyr Ile Pro Phe Pro Glu 
            20                  25                  30          


Asp Asp Ser Asn Ser Thr Asn His Asn Leu Glu Lys Val Glu Tyr Ala 
        35                  40                  45              


Phe Leu Ile Ile Phe Thr Val Glu Thr Phe Leu Lys Ile Ile Ala Tyr 
    50                  55                  60                  


Gly Leu Leu Leu His Pro Asn Ala Tyr Val Arg Asn Gly Trp Asn Leu 
65                  70                  75                  80  


Leu Asp Phe Val Ile Val Val Val Gly Leu Phe Ser Val Ile Leu Glu 
                85                  90                  95      


Gln Leu Thr Lys Glu Thr Glu Gly Gly Ser His Ser Gly Gly Lys Pro 
            100                 105                 110         


Gly Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg Val Leu Arg Pro 
        115                 120                 125             


Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val Val Leu Asn Ser 
    130                 135                 140                 


Ile Ile Lys Ala Met Val 
145                 150 


<210> 121
<211> 150
<212> PRT
<213> Homo sapiens

<400> 121
Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile Ile Ile Leu Leu Thr 
1               5                   10                  15      


Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr Ile Pro Phe Pro Glu 
            20                  25                  30          


Asp Asp Ser Asn Ala Thr Asn Ser Asn Leu Glu Arg Val Glu Tyr Leu 
        35                  40                  45              


Phe Leu Ile Ile Phe Thr Val Glu Ala Phe Leu Lys Val Ile Ala Tyr 
    50                  55                  60                  


Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg Asn Gly Trp Asn Leu 
65                  70                  75                  80  


Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe Ser Ala Ile Leu Glu 
                85                  90                  95      


Gln Ala Thr Lys Ala Asp Gly Ala Asn Ala Leu Gly Gly Lys Gly Ala 
            100                 105                 110         


Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg Val Leu Arg Pro Leu 
        115                 120                 125             


Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val Val Leu Asn Ser Ile 
    130                 135                 140                 


Ile Lys Ala Met Val Pro 
145                 150 


<210> 122
<211> 138
<212> PRT
<213> Drosophila melanogaster

<400> 122
Ile Arg Ile Val Glu Trp Lys Pro Phe Glu Phe Leu Ile Leu Leu Thr 
1               5                   10                  15      


Ile Phe Ala Asn Cys Ile Ala Leu Ala Val Tyr Thr Pro Tyr Pro Gly 
            20                  25                  30          


Ser Asp Ser Asn Val Thr Asn Gln Thr Leu Glu Lys Val Glu Tyr Val 
        35                  40                  45              


Phe Leu Val Ile Phe Thr Ala Glu Cys Val Met Lys Ile Leu Ala Tyr 
    50                  55                  60                  


Gly Phe Val Leu His Asn Gly Ala Tyr Leu Arg Asn Gly Trp Asn Leu 
65                  70                  75                  80  


Leu Asp Phe Thr Ile Val Val Ile Gly Ala Ile Ser Thr Ala Leu Ser 
                85                  90                  95      


Gln Leu Met Lys Asp Ala Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
            100                 105                 110         


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
        115                 120                 125             


Val Leu Asn Ser Ile Leu Lys Ala Met Val 
    130                 135             


<210> 123
<211> 134
<212> PRT
<213> Homo sapiens

<400> 123
Lys Lys Ile Thr Glu Trp Pro Pro Phe Glu Tyr Met Ile Leu Ala Thr 
1               5                   10                  15      


Ile Ile Ala Asn Cys Ile Val Leu Ala Leu Glu Gln His Leu Pro Asp 
            20                  25                  30          


Asp Asp Lys Thr Pro Met Ser Glu Arg Leu Asp Asp Thr Glu Pro Tyr 
        35                  40                  45              


Phe Ile Gly Ile Phe Cys Phe Glu Ala Gly Ile Lys Ile Ile Ala Leu 
    50                  55                  60                  


Gly Phe Ala Phe His Lys Gly Ser Tyr Leu Arg Asn Gly Trp Asn Val 
65                  70                  75                  80  


Met Asp Phe Val Val Val Leu Thr Gly Ile Leu Ala Thr Val Gly Thr 
                85                  90                  95      


Glu Phe Asp Leu Arg Thr Leu Arg Ala Val Arg Val Leu Arg Pro Leu 
            100                 105                 110         


Lys Leu Val Ser Gly Ile Pro Ser Leu Gln Val Val Leu Lys Ser Ile 
        115                 120                 125             


Met Lys Ala Met Ile Pro 
    130                 


<210> 124
<211> 133
<212> PRT
<213> Homo sapiens

<400> 124
Lys Arg Ile Thr Glu Trp Pro Pro Phe Glu Tyr Met Ile Leu Ala Thr 
1               5                   10                  15      


Ile Ile Ala Asn Cys Ile Val Leu Ala Leu Glu Gln His Leu Pro Asp 
            20                  25                  30          


Gly Asp Lys Thr Pro Met Ser Glu Arg Leu Asp Asp Thr Glu Pro Tyr 
        35                  40                  45              


Phe Ile Gly Ile Phe Cys Phe Glu Ala Gly Ile Lys Ile Ile Ala Leu 
    50                  55                  60                  


Gly Phe Val Phe His Lys Gly Ser Tyr Leu Arg Asn Gly Trp Asn Val 
65                  70                  75                  80  


Met Asp Phe Val Val Val Leu Thr Gly Ile Leu Ala Thr Ala Gly Thr 
                85                  90                  95      


Asp Phe Asp Leu Arg Thr Leu Arg Ala Val Arg Val Leu Arg Pro Leu 
            100                 105                 110         


Lys Leu Val Ser Gly Ile Pro Ser Leu Gln Val Val Leu Lys Ser Ile 
        115                 120                 125             


Met Lys Ala Met Val 
    130             


<210> 125
<211> 128
<212> PRT
<213> Rattus norvegicus

<400> 125
Tyr Gln Ile Val Lys His Ser Trp Phe Glu Ser Phe Ile Ile Phe Val 
1               5                   10                  15      


Ile Leu Leu Ser Ser Gly Ala Leu Ile Phe Glu Asp Val Asn Leu Pro 
            20                  25                  30          


Ser Arg Pro Gln Val Glu Lys Leu Leu Arg Cys Thr Asp Asn Ile Phe 
        35                  40                  45              


Thr Phe Ile Phe Leu Leu Glu Met Ile Leu Lys Trp Val Ala Phe Gly 
    50                  55                  60                  


Phe Arg Arg Tyr Phe Thr Ser Ala Trp Cys Trp Leu Asp Phe Leu Ile 
65                  70                  75                  80  


Val Val Val Ser Val Leu Ser Leu Met Asn Leu Pro Ser Leu Lys Ser 
                85                  90                  95      


Phe Arg Thr Leu Arg Ala Leu Arg Pro Leu Arg Ala Leu Ser Gln Phe 
            100                 105                 110         


Glu Gly Met Lys Val Val Val Tyr Ala Leu Ile Ser Ala Ile Pro Ala 
        115                 120                 125             


<210> 126
<211> 128
<212> PRT
<213> Mus musculus

<400> 126
Tyr Gln Ile Val Lys His Ser Trp Phe Glu Ser Phe Ile Ile Phe Val 
1               5                   10                  15      


Ile Leu Leu Ser Ser Gly Ala Leu Ile Phe Glu Asp Val Asn Leu Pro 
            20                  25                  30          


Ser Arg Pro Gln Val Glu Lys Leu Leu Lys Cys Thr Asp Asn Ile Phe 
        35                  40                  45              


Thr Phe Ile Phe Leu Leu Glu Met Ile Leu Lys Trp Val Ala Phe Gly 
    50                  55                  60                  


Phe Arg Lys Tyr Phe Thr Ser Ala Trp Cys Trp Leu Asp Phe Leu Ile 
65                  70                  75                  80  


Val Val Val Ser Gly Leu Ser Leu Thr Asn Leu Pro Asn Leu Lys Ser 
                85                  90                  95      


Phe Arg Asn Leu Arg Ala Leu Arg Pro Leu Arg Ala Leu Ser Gln Phe 
            100                 105                 110         


Glu Gly Met Lys Val Val Val Asn Ala Leu Met Ser Ala Ile Pro Ala 
        115                 120                 125             


<210> 127
<211> 135
<212> PRT
<213> Rattus norvegicus

<400> 127
Tyr Arg Ile Val Glu His Ser Trp Phe Glu Ser Phe Ile Val Leu Met 
1               5                   10                  15      


Ile Leu Leu Ser Ser Gly Ala Leu Ala Phe Glu Asp Ile Tyr Ile Glu 
            20                  25                  30          


Lys Lys Lys Thr Ile Lys Ile Ile Leu Glu Tyr Ala Asp Lys Ile Phe 
        35                  40                  45              


Thr Tyr Ile Phe Ile Leu Glu Met Leu Leu Lys Trp Val Ala Tyr Gly 
    50                  55                  60                  


Tyr Lys Thr Tyr Phe Thr Asn Ala Trp Cys Trp Leu Asp Phe Leu Ile 
65                  70                  75                  80  


Val Asp Val Ser Leu Val Thr Leu Val Ala Asn Thr Leu Gly Tyr Ser 
                85                  90                  95      


Asp Leu Gly Pro Ile Lys Ser Leu Arg Thr Leu Arg Ala Leu Arg Pro 
            100                 105                 110         


Leu Arg Ala Leu Ser Arg Phe Glu Gly Met Arg Val Val Val Asn Ala 
        115                 120                 125             


Leu Ile Gly Ala Ile Pro Ser 
    130                 135 


<210> 128
<211> 135
<212> PRT
<213> Oryctolagus cuniculus

<400> 128
Tyr Arg Ile Val Glu His Ser Trp Phe Glu Ser Phe Ile Val Leu Met 
1               5                   10                  15      


Ile Leu Leu Ser Ser Gly Ala Leu Ala Phe Glu Asp Ile Tyr Ile Glu 
            20                  25                  30          


Lys Lys Lys Thr Ile Lys Ile Ile Leu Glu Tyr Ala Asp Lys Ile Phe 
        35                  40                  45              


Thr Tyr Ile Phe Ile Leu Glu Met Leu Leu Lys Trp Val Ala Tyr Gly 
    50                  55                  60                  


Tyr Lys Thr Tyr Phe Thr Asn Ala Trp Cys Trp Leu Asp Phe Leu Ile 
65                  70                  75                  80  


Val Asp Val Ser Leu Val Thr Leu Val Ala Asn Thr Leu Gly Tyr Ser 
                85                  90                  95      


Asp Leu Gly Pro Ile Lys Ser Leu Arg Thr Leu Arg Ala Leu Arg Pro 
            100                 105                 110         


Leu Arg Ala Leu Ser Arg Phe Glu Gly Met Arg Val Val Val Asn Ala 
        115                 120                 125             


Leu Ile Gly Ala Ile Pro Ser 
    130                 135 


<210> 129
<211> 135
<212> PRT
<213> Mus musculus

<400> 129
Tyr Arg Ile Val Glu His Ser Trp Phe Glu Ser Phe Ile Val Leu Met 
1               5                   10                  15      


Ile Leu Leu Ser Ser Gly Ala Leu Ala Phe Glu Asp Ile Tyr Ile Glu 
            20                  25                  30          


Lys Lys Lys Thr Ile Lys Ile Ile Leu Glu Tyr Ala Asp Lys Ile Phe 
        35                  40                  45              


Thr Tyr Ile Phe Ile Leu Glu Met Leu Leu Lys Trp Val Ala Tyr Gly 
    50                  55                  60                  


Tyr Lys Thr Tyr Phe Thr Asn Ala Trp Cys Trp Leu Asp Phe Leu Ile 
65                  70                  75                  80  


Val Asp Val Ser Leu Val Thr Leu Val Ala Asn Thr Leu Gly Tyr Ser 
                85                  90                  95      


Asp Leu Gly Pro Ile Lys Ser Leu Arg Thr Leu Arg Ala Leu Arg Pro 
            100                 105                 110         


Leu Arg Ala Leu Ser Arg Phe Glu Gly Met Arg Val Val Val Asn Ala 
        115                 120                 125             


Leu Ile Gly Ala Ile Pro Ser 
    130                 135 


<210> 130
<211> 162
<212> PRT
<213> Mus musculus

<400> 130
Thr Trp Asp Trp Ile Ile Leu Ile Leu Thr Phe Tyr Thr Ala Ile Leu 
1               5                   10                  15      


Val Pro Tyr Asn Val Ser Phe Lys Thr Arg Gln Asn Asn Val Ala Trp 
            20                  25                  30          


Leu Val Val Asp Ser Ile Val Asp Val Ile Phe Leu Val Asp Ile Val 
        35                  40                  45              


Leu Asn Phe His Thr Thr Phe Val Gly Pro Ala Gly Glu Val Ile Ser 
    50                  55                  60                  


Asp Pro Lys Leu Ile Arg Met Asn Tyr Leu Lys Thr Trp Phe Val Ile 
65                  70                  75                  80  


Asp Leu Leu Ser Cys Leu Pro Tyr Asp Val Ile Asn Ala Phe Glu Asn 
                85                  90                  95      


Val Asp Glu Val Ser Ala Phe Met Gly Asp Pro Gly Lys Ile Gly Phe 
            100                 105                 110         


Ala Asp Gln Ile Pro Pro Pro Leu Glu Gly Arg Glu Ser Gln Gly Ile 
        115                 120                 125             


Ser Ser Leu Phe Ser Ser Leu Lys Val Val Arg Leu Leu Arg Leu Gly 
    130                 135                 140                 


Arg Val Ala Arg Lys Leu Asp His Tyr Ile Glu Tyr Gly Ala Ala Val 
145                 150                 155                 160 


Leu Val 
        


<210> 131
<211> 140
<212> PRT
<213> Mus musculus

<400> 131
Gly Trp Asp Trp Leu Ile Leu Leu Ala Thr Phe Tyr Val Ala Val Thr 
1               5                   10                  15      


Val Pro Tyr Asn Val Cys Phe Ile Gly Asn Glu Asp Leu Ser Thr Thr 
            20                  25                  30          


Arg Ser Thr Thr Val Ser Asp Ile Ala Val Glu Ile Leu Phe Ile Ile 
        35                  40                  45              


Asp Ile Ile Leu Asn Phe Arg Thr Thr Tyr Val Ser Lys Ser Gly Gln 
    50                  55                  60                  


Val Ile Phe Glu Ala Arg Ser Ile Cys Ile His Tyr Val Thr Thr Trp 
65                  70                  75                  80  


Phe Ile Ile Asp Leu Ile Ala Ala Leu Pro Phe Asp Leu Leu Tyr Ala 
                85                  90                  95      


Phe Asn Val Thr Val Val Ser Leu Val His Leu Leu Lys Thr Val Arg 
            100                 105                 110         


Leu Leu Arg Leu Leu Arg Leu Leu Gln Lys Leu Asp Arg Tyr Ser Gln 
        115                 120                 125             


His Ser Thr Ile Val Leu Thr Leu Leu Met Ser Met 
    130                 135                 140 


<210> 132
<211> 136
<212> PRT
<213> Homo sapiens

<400> 132
Thr Trp Asp Gly Phe Ile Leu Leu Ala Thr Leu Tyr Val Ala Val Thr 
1               5                   10                  15      


Val Pro Tyr Ser Val Cys Val Ser Thr Ala Arg Glu Pro Ser Ala Ala 
            20                  25                  30          


Arg Gly Pro Pro Ser Val Cys Asp Leu Ala Val Glu Val Leu Phe Ile 
        35                  40                  45              


Leu Asp Ile Val Leu Asn Phe Arg Thr Thr Phe Val Ser Lys Ser Gly 
    50                  55                  60                  


Gln Val Val Phe Ala Pro Lys Ser Ile Cys Leu His Tyr Val Thr Thr 
65                  70                  75                  80  


Trp Phe Leu Leu Asp Val Ile Ala Ala Leu Pro Phe Asp Leu Leu His 
                85                  90                  95      


Ala Phe Lys Val Asn Val Tyr Phe Gly Ala His Leu Leu Lys Thr Val 
            100                 105                 110         


Arg Leu Leu Arg Leu Leu Arg Leu Leu Pro Arg Leu Asp Arg Tyr Ser 
        115                 120                 125             


Gln Tyr Ser Ala Val Val Leu Thr 
    130                 135     


<210> 133
<211> 138
<212> PRT
<213> Homo sapiens

<400> 133
His His Leu Cys Thr Ser His Tyr Leu Asp Leu Phe Ile Thr Gly Val 
1               5                   10                  15      


Ile Gly Leu Asn Val Val Thr Met Ala Met Glu His Tyr Gln Gln Pro 
            20                  25                  30          


Gln Ile Leu Asp Glu Ala Leu Lys Ile Cys Asn Tyr Ile Phe Thr Val 
        35                  40                  45              


Ile Phe Val Leu Glu Ser Val Phe Lys Leu Val Ala Phe Gly Phe Arg 
    50                  55                  60                  


Arg Phe Phe Gln Asp Arg Trp Asn Gln Leu Asp Leu Ala Ile Val Leu 
65                  70                  75                  80  


Leu Ser Ile Met Gly Ile Thr Leu Glu Glu Ile Glu Val Asn Ala Ser 
                85                  90                  95      


Leu Pro Ile Asn Pro Thr Ile Ile Arg Ile Met Arg Val Leu Arg Ile 
            100                 105                 110         


Ala Arg Val Leu Lys Leu Leu Lys Met Ala Val Gly Met Arg Ala Leu 
        115                 120                 125             


Leu Asp Thr Val Met Gln Ala Leu Pro Gln 
    130                 135             


<210> 134
<211> 135
<212> PRT
<213> Mus musculus

<400> 134
Phe Asp Leu Val Thr Ser Gln Val Phe Asp Val Ile Ile Leu Gly Leu 
1               5                   10                  15      


Ile Val Thr Asn Met Ile Ile Met Met Ala Glu Ser Glu Gly Gln Pro 
            20                  25                  30          


Asn Glu Val Lys Lys Ile Phe Asp Ile Leu Asn Ile Val Phe Val Val 
        35                  40                  45              


Ile Phe Thr Val Glu Cys Leu Ile Lys Val Phe Ala Leu Arg Gln His 
    50                  55                  60                  


Tyr Phe Thr Asn Gly Trp Asn Leu Phe Asp Cys Val Val Val Val Leu 
65                  70                  75                  80  


Ser Ile Ile Ser Thr Leu Val Ser Gly Leu Glu Asn Ser Asn Val Phe 
                85                  90                  95      


Pro Pro Thr Leu Phe Arg Ile Val Arg Leu Ala Arg Ile Gly Arg Ile 
            100                 105                 110         


Leu Arg Leu Val Arg Ala Ala Arg Gly Ile Arg Thr Leu Leu Phe Ala 
        115                 120                 125             


Leu Met Met Ser Leu Pro Ser 
    130                 135 


<210> 135
<211> 135
<212> PRT
<213> Rattus norvegicus

<400> 135
Phe Asp Leu Val Thr Asn Gln Ala Phe Asp Ile Thr Ile Met Val Leu 
1               5                   10                  15      


Ile Cys Leu Asn Met Val Thr Met Met Val Glu Lys Glu Gly Gln Thr 
            20                  25                  30          


Glu Tyr Met Asp Tyr Val Leu His Trp Ile Asn Met Val Phe Ile Ile 
        35                  40                  45              


Leu Phe Thr Gly Glu Cys Val Leu Lys Leu Ile Ser Leu Arg His Tyr 
    50                  55                  60                  


Tyr Phe Thr Val Gly Trp Asn Ile Phe Asp Phe Val Val Val Ile Leu 
65                  70                  75                  80  


Ser Ile Val Gly Met Phe Leu Ala Glu Met Ile Glu Lys Tyr Phe Val 
                85                  90                  95      


Ser Pro Thr Leu Phe Arg Val Ile Arg Leu Ala Arg Ile Gly Arg Ile 
            100                 105                 110         


Leu Arg Leu Ile Lys Gly Ala Lys Gly Ile Arg Thr Leu Leu Phe Ala 
        115                 120                 125             


Leu Met Met Ser Leu Pro Ala 
    130                 135 


<210> 136
<211> 136
<212> PRT
<213> Rattus norvegicus

<400> 136
Phe Asp Leu Val Thr Ser Gln Val Phe Asp Val Ile Ile Leu Gly Leu 
1               5                   10                  15      


Ile Val Leu Asn Met Ile Ile Met Met Ala Glu Ser Ala Asp Gln Pro 
            20                  25                  30          


Lys Asp Val Lys Lys Thr Phe Asp Ile Leu Asn Ile Ala Phe Val Val 
        35                  40                  45              


Ile Phe Thr Ile Glu Cys Leu Ile Lys Val Phe Ala Leu Arg Gln His 
    50                  55                  60                  


Tyr Phe Thr Asn Gly Trp Asn Leu Phe Asp Cys Val Val Val Val Leu 
65                  70                  75                  80  


Ser Ile Ile Ser Thr Leu Val Ser Arg Leu Glu Asp Ser Asp Ile Ser 
                85                  90                  95      


Phe Pro Pro Thr Leu Phe Arg Val Val Arg Leu Ala Arg Ile Gly Arg 
            100                 105                 110         


Ile Leu Arg Leu Val Arg Ala Ala Arg Gly Ile Arg Thr Leu Leu Phe 
        115                 120                 125             


Ala Leu Met Met Ser Leu Pro Ser 
    130                 135     


<210> 137
<211> 128
<212> PRT
<213> Homo sapiens

<400> 137
Arg Lys Ile Val Asp Ser Lys Tyr Phe Gly Arg Gly Ile Met Ile Ala 
1               5                   10                  15      


Ile Leu Val Asn Thr Leu Ser Met Gly Ile Glu Tyr His Glu Gln Pro 
            20                  25                  30          


Glu Glu Leu Thr Asn Ala Leu Glu Ile Ser Asn Ile Val Phe Thr Ser 
        35                  40                  45              


Leu Phe Ala Leu Glu Met Leu Leu Lys Leu Leu Val Tyr Gly Pro Phe 
    50                  55                  60                  


Gly Tyr Ile Lys Asn Pro Tyr Asn Ile Phe Asp Gly Val Ile Val Val 
65                  70                  75                  80  


Ile Ser Val Trp Glu Ile Val Gly Gln Gln Gly Gly Gly Leu Ser Val 
                85                  90                  95      


Leu Arg Thr Phe Arg Leu Met Arg Val Leu Lys Leu Val Arg Phe Leu 
            100                 105                 110         


Pro Ala Leu Gln Arg Gln Leu Val Val Leu Met Lys Thr Met Asp Asn 
        115                 120                 125             


<210> 138
<211> 135
<212> PRT
<213> Homo sapiens

<400> 138
Trp His Phe Val Val Ser Pro Ser Phe Glu Tyr Thr Ile Met Ala Met 
1               5                   10                  15      


Ile Ala Leu Asn Thr Val Val Leu Met Met Lys Tyr Tyr Ser Ala Pro 
            20                  25                  30          


Cys Thr Tyr Glu Leu Ala Leu Lys Tyr Leu Asn Ile Ala Phe Thr Met 
        35                  40                  45              


Val Phe Ser Leu Glu Cys Val Leu Lys Val Ile Ala Phe Gly Phe Leu 
    50                  55                  60                  


Asn Tyr Phe Arg Asp Thr Trp Asn Ile Phe Asp Phe Ile Thr Val Ile 
65                  70                  75                  80  


Gly Ser Ile Thr Glu Ile Ile Leu Thr Asp Ser Lys Leu Val Asn Thr 
                85                  90                  95      


Ser Gly Phe Asn Met Ser Phe Leu Lys Leu Phe Arg Ala Ala Arg Leu 
            100                 105                 110         


Ile Lys Leu Leu Arg Gln Gly Tyr Thr Ile Arg Ile Leu Leu Trp Thr 
        115                 120                 125             


Phe Val Gln Ser Phe Lys Ala 
    130                 135 


<210> 139
<211> 128
<212> PRT
<213> Drosophila melanogaster

<400> 139
Trp Arg Ile Val Val Ser Thr Pro Phe Glu Tyr Phe Ile Met Met Leu 
1               5                   10                  15      


Ile Val Phe Asn Thr Leu Leu Leu Met Met Lys Tyr His Asn Gln Gly 
            20                  25                  30          


Asp Met Tyr Glu Lys Ser Leu Lys Tyr Ile Asn Met Gly Phe Thr Gly 
        35                  40                  45              


Met Phe Ser Val Glu Thr Val Leu Lys Ile Ile Gly Phe Gly Val Lys 
    50                  55                  60                  


Asn Phe Phe Lys Asp Pro Trp Asn Ile Phe Asp Leu Ile Thr Val Leu 
65                  70                  75                  80  


Gly Ser Ile Val Asp Ala Leu Trp Met Glu Phe Gly His Asp Asp Ser 
                85                  90                  95      


Asn Ser Ile Asn Val Gly Phe Leu Arg Leu Phe Arg Ala Ala Arg Leu 
            100                 105                 110         


Ile Lys Leu Leu Arg Gln Gly Tyr Thr Ile Arg Ile Leu Leu Trp Thr 
        115                 120                 125             


<210> 140
<211> 164
<212> PRT
<213> Homo sapiens

<400> 140
Trp Asn Leu Met Glu Lys Pro Phe Ser Ser Val Ala Ala Lys Ala Ile 
1               5                   10                  15      


Gly Val Ala Ser Ser Thr Phe Val Leu Val Ser Val Val Ala Leu Ala 
            20                  25                  30          


Leu Asn Thr Val Glu Glu Met Gln Gln His Ser Gly Gln Gly Glu Gly 
        35                  40                  45              


Gly Pro Asp Leu Arg Pro Ile Leu Glu His Val Glu Met Leu Cys Met 
    50                  55                  60                  


Gly Phe Phe Thr Leu Glu Tyr Leu Leu Arg Leu Ala Ser Thr Pro Asp 
65                  70                  75                  80  


Leu Arg Arg Phe Ala Arg Ser Ala Leu Asn Leu Val Asp Leu Val Ala 
                85                  90                  95      


Ile Leu Pro Leu Tyr Leu Gln Leu Leu Leu Glu Cys Phe Thr Gly Glu 
            100                 105                 110         


Gly His Gln Arg Gly Gln Thr Val Gly Ser Val Gly Lys Val Gly Gln 
        115                 120                 125             


Val Leu Arg Val Met Arg Leu Met Arg Ile Phe Arg Ile Leu Lys Leu 
    130                 135                 140                 


Ala Arg His Ser Thr Gly Leu Arg Ala Phe Gly Phe Thr Leu Arg Gln 
145                 150                 155                 160 


Cys Tyr Gln Gln 
                


<210> 141
<211> 155
<212> PRT
<213> Homo sapiens

<400> 141
Trp Lys Phe Leu Glu Lys Pro Glu Ser Ser Cys Pro Ala Arg Val Val 
1               5                   10                  15      


Ala Val Leu Ser Phe Leu Leu Ile Leu Val Ser Ser Val Val Met Cys 
            20                  25                  30          


Met Gly Thr Ile Pro Glu Leu Gln Val Leu Asp Ala Glu Gly Asn Arg 
        35                  40                  45              


Val Glu His Pro Thr Leu Glu Asn Val Glu Thr Ala Cys Ile Gly Trp 
    50                  55                  60                  


Phe Thr Leu Glu Tyr Leu Leu Arg Leu Phe Ser Ser Pro Asn Lys Leu 
65                  70                  75                  80  


His Phe Ala Leu Ser Phe Met Asn Ile Val Asp Val Leu Ala Ile Leu 
                85                  90                  95      


Pro Phe Tyr Val Ser Leu Thr Leu Thr His Leu Gly Ala Arg Met Met 
            100                 105                 110         


Glu Leu Thr Asn Val Gln Gln Ala Val Gln Ala Leu Arg Ile Met Arg 
        115                 120                 125             


Ile Ala Arg Ile Phe Lys Leu Ala Arg His Ser Ser Gly Leu Gln Thr 
    130                 135                 140                 


Leu Thr Tyr Ala Leu Lys Arg Ser Phe Lys Glu 
145                 150                 155 


<210> 142
<211> 155
<212> PRT
<213> Homo sapiens

<400> 142
Trp Asp Leu Leu Glu Lys Pro Asn Ser Ser Val Ala Ala Lys Ile Leu 
1               5                   10                  15      


Ala Ile Ile Ser Ile Met Phe Ile Val Leu Ser Thr Ile Ala Leu Ser 
            20                  25                  30          


Leu Asn Thr Leu Pro Glu Leu Gln Ser Leu Asp Glu Phe Gly Gln Ser 
        35                  40                  45              


Thr Asp Asn Pro Gln Leu Ala His Val Glu Ala Val Cys Ile Ala Trp 
    50                  55                  60                  


Phe Thr Met Glu Tyr Leu Leu Arg Phe Leu Ser Ser Pro Lys Lys Trp 
65                  70                  75                  80  


Lys Phe Phe Lys Gly Pro Leu Asn Ala Ile Asp Leu Leu Ala Ile Leu 
                85                  90                  95      


Pro Tyr Tyr Val Thr Ile Phe Leu Thr Glu Ser Asn Lys Ser Val Leu 
            100                 105                 110         


Gln Phe Gln Asn Val Arg Arg Val Val Gln Ile Phe Arg Ile Met Arg 
        115                 120                 125             


Ile Leu Arg Ile Leu Lys Leu Ala Arg His Ser Thr Gly Leu Gln Ser 
    130                 135                 140                 


Leu Gly Phe Thr Leu Arg Arg Ser Tyr Asn Glu 
145                 150                 155 


<210> 143
<211> 155
<212> PRT
<213> Canis lupus

<400> 143
Arg Asp Leu Leu Glu Lys Pro Asn Ser Ser Val Ala Ala Lys Ile Leu 
1               5                   10                  15      


Ala Ile Val Ser Asn Leu Phe Ile Val Leu Ser Thr Ile Ala Leu Ser 
            20                  25                  30          


Leu Asn Thr Leu Pro Glu Leu Gln Glu Met Asp Glu Phe Gly Gln Pro 
        35                  40                  45              


Asn Asp Asn Pro Gln Leu Ala His Val Glu Ala Val Cys Asn Ala Trp 
    50                  55                  60                  


Phe Thr Met Glu Tyr Leu Leu Arg Phe Leu Ser Ser Pro Asn Lys Trp 
65                  70                  75                  80  


Lys Phe Phe Lys Gly Pro Leu Asn Val Ile Asp Leu Leu Ala Ile Leu 
                85                  90                  95      


Pro Tyr Tyr Val Thr Ile Phe Leu Thr Glu Ser Asn Lys Ser Val Leu 
            100                 105                 110         


Gln Phe Gln Asn Val Arg Arg Val Val Gln Ile Phe Arg Ile Met Arg 
        115                 120                 125             


Ile Leu Arg Ile Leu Lys Leu Ala Arg His Ser Thr Gly Leu Gln Ser 
    130                 135                 140                 


Leu Gly Phe Thr Leu Arg Arg Ser Tyr Asn Glu 
145                 150                 155 


<210> 144
<211> 155
<212> PRT
<213> Drosophila melanogaster

<400> 144
Trp Glu Leu Leu Glu Lys Pro Asn Thr Ser Phe Ala Ala Arg Val Ile 
1               5                   10                  15      


Ala Val Ile Ser Ile Leu Phe Ile Val Leu Ser Thr Ile Ala Leu Thr 
            20                  25                  30          


Leu Asn Thr Leu Pro Gln Leu Gln His Ile Asp Asn Gly Thr Pro Gln 
        35                  40                  45              


Asp Asn Pro Gln Leu Ala Met Val Glu Ala Val Cys Ile Thr Trp Phe 
    50                  55                  60                  


Thr Leu Glu Tyr Ile Leu Arg Phe Ser Ala Ser Pro Asp Lys Trp Lys 
65                  70                  75                  80  


Phe Phe Lys Gly Gly Leu Asn Ile Ile Asp Leu Leu Ala Ile Leu Pro 
                85                  90                  95      


Tyr Phe Val Ser Leu Phe Leu Leu Glu Thr Asn Lys Asn Ala Thr Asp 
            100                 105                 110         


Gln Phe Gln Asp Val Arg Arg Val Val Gln Val Phe Arg Ile Met Arg 
        115                 120                 125             


Ile Leu Arg Val Leu Lys Leu Ala Arg His Ser Thr Gly Leu Gln Ser 
    130                 135                 140                 


Leu Gly Phe Thr Leu Arg Asn Ser Tyr Lys Glu 
145                 150                 155 


<210> 145
<211> 149
<212> PRT
<213> Pongo abelii

<400> 145
Trp Asn Ile Leu Glu Lys Pro Gly Ser Ser Thr Ala Ala Arg Ile Phe 
1               5                   10                  15      


Gly Val Ile Ser Ile Ile Phe Val Val Val Ser Ile Ile Asn Met Ala 
            20                  25                  30          


Leu Met Ser Ala Glu Leu Ser Trp Leu Asp Leu Gln Leu Leu Glu Ile 
        35                  40                  45              


Leu Glu Tyr Val Cys Ile Ser Trp Phe Thr Gly Glu Phe Val Leu Arg 
    50                  55                  60                  


Phe Leu Cys Val Arg Asp Arg Cys Arg Phe Leu Arg Lys Val Pro Asn 
65                  70                  75                  80  


Ile Ile Asp Leu Leu Ala Ile Leu Pro Phe Tyr Ile Thr Leu Leu Val 
                85                  90                  95      


Glu Ser Leu Ser Gly Ser Gln Thr Thr Gln Glu Leu Glu Asn Val Gly 
            100                 105                 110         


Arg Ile Val Gln Val Leu Arg Leu Leu Arg Ala Leu Arg Met Leu Lys 
        115                 120                 125             


Leu Gly Arg His Ser Thr Gly Leu Arg Ser Leu Gly Met Thr Ile Thr 
    130                 135                 140                 


Gln Cys Tyr Glu Glu 
145                 


<210> 146
<211> 152
<212> PRT
<213> Homo sapiens

<400> 146
Trp Ile Arg Met Glu Asn Pro Ala Tyr Cys Leu Ser Ala Lys Leu Ile 
1               5                   10                  15      


Ala Ile Ser Ser Leu Ser Val Val Leu Ala Ser Ile Val Ala Met Cys 
            20                  25                  30          


Val His Ser Met Ser Glu Phe Gln Asn Glu Asp Gly Glu Val Asp Asp 
        35                  40                  45              


Pro Val Leu Glu Gly Val Glu Ile Ala Cys Ile Ala Trp Phe Thr Gly 
    50                  55                  60                  


Glu Leu Ala Val Arg Leu Ala Ala Ala Pro Cys Gln Lys Lys Phe Trp 
65                  70                  75                  80  


Lys Asn Pro Leu Asn Ile Ile Asp Phe Val Ser Ile Ile Pro Phe Tyr 
                85                  90                  95      


Ala Thr Leu Ala Val Asp Thr Lys Glu Glu Glu Ser Glu Asp Ile Glu 
            100                 105                 110         


Asn Met Gly Lys Val Val Gln Ile Leu Arg Leu Met Arg Ile Phe Arg 
        115                 120                 125             


Ile Leu Lys Leu Ala Arg His Ser Val Gly Leu Arg Ser Leu Gly Ala 
    130                 135                 140                 


Thr Leu Arg His Ser Tyr His Glu 
145                 150         


<210> 147
<211> 172
<212> PRT
<213> Saimiri boliviensis

<400> 147
Trp Leu Thr Met Glu Asn Pro Gly Tyr Ser Leu Pro Ser Lys Leu Phe 
1               5                   10                  15      


Ser Cys Val Ser Ile Ser Val Val Leu Ala Ser Ile Ala Ala Met Cys 
            20                  25                  30          


Ile His Ser Leu Pro Glu Tyr Gln Ala Arg Glu Ala Ala Ala Ala Val 
        35                  40                  45              


Ala Ala Val Ala Ala Gly Arg Ser Ala Glu Gly Val Arg Asp Asp Pro 
    50                  55                  60                  


Val Leu Arg Arg Leu Glu Tyr Phe Cys Ile Ala Trp Phe Ser Phe Glu 
65                  70                  75                  80  


Val Ser Ser Arg Leu Leu Leu Ala Pro Ser Thr Arg Asn Phe Phe Cys 
                85                  90                  95      


His Pro Leu Asn Leu Ile Asp Ile Val Ser Val Leu Pro Phe Tyr Leu 
            100                 105                 110         


Thr Leu Leu Ala Gly Ala Ala Leu Gly Asp Gln Gly Gly Thr Gly Gly 
        115                 120                 125             


Lys Glu Phe Gly His Leu Gly Lys Val Val Gln Val Phe Arg Leu Met 
    130                 135                 140                 


Arg Ile Phe Arg Val Leu Lys Leu Ala Arg His Ser Thr Gly Leu Arg 
145                 150                 155                 160 


Ser Leu Gly Ala Thr Leu Lys His Ser Tyr Arg Glu 
                165                 170         


<210> 148
<211> 166
<212> PRT
<213> Gallus gallus

<400> 148
Arg Asp Met Val Glu Asn Pro His Ser Gly Ile Pro Gly Lys Ile Phe 
1               5                   10                  15      


Ala Cys Ile Ser Ile Ser Phe Val Ala Ile Thr Ala Val Ser Leu Cys 
            20                  25                  30          


Ile Ser Thr Met Pro Asp Val Arg Glu Glu Glu Asp Arg Gly Glu Cys 
        35                  40                  45              


Ser Gln Lys Cys Tyr Asp Ile Phe Val Leu Glu Thr Val Cys Val Ala 
    50                  55                  60                  


Trp Phe Ser Phe Glu Phe Leu Leu Arg Ser Ile Gln Ala Glu Asn Lys 
65                  70                  75                  80  


Cys Ala Phe Leu Lys Thr Pro Leu Asn Ile Ile Asp Ile Leu Ala Ile 
                85                  90                  95      


Leu Pro Phe Tyr Ile Ser Leu Ile Val Asp Met Ala Ser Thr Lys Asn 
            100                 105                 110         


Ser Ser Lys Pro Gly Gly Gly Ala Gly Asn Lys Tyr Leu Glu Arg Val 
        115                 120                 125             


Gly Leu Val Leu Arg Phe Leu Arg Ala Leu Arg Ile Leu Tyr Val Met 
    130                 135                 140                 


Arg Leu Ala Arg His Ser Leu Gly Leu Gln Thr Leu Gly Leu Thr Val 
145                 150                 155                 160 


Arg Arg Cys Thr Arg Glu 
                165     


<210> 149
<211> 163
<212> PRT
<213> Homo sapiens

<400> 149
Arg Glu Met Val Glu Asn Pro Gln Ser Gly Leu Pro Gly Lys Val Phe 
1               5                   10                  15      


Ala Cys Leu Ser Ile Leu Phe Val Ala Thr Thr Ala Val Ser Leu Cys 
            20                  25                  30          


Val Ser Thr Met Pro Asp Leu Arg Ala Glu Glu Asp Gln Gly Glu Cys 
        35                  40                  45              


Ser Arg Lys Cys Tyr Tyr Ile Phe Ile Val Glu Thr Ile Cys Val Ala 
    50                  55                  60                  


Trp Phe Ser Leu Glu Phe Cys Leu Arg Phe Val Gln Ala Gln Asp Lys 
65                  70                  75                  80  


Cys Gln Phe Phe Gln Gly Pro Leu Asn Ile Ile Asp Ile Leu Ala Ile 
                85                  90                  95      


Ser Pro Tyr Tyr Val Ser Leu Ala Val Ser Glu Glu Pro Pro Glu Asp 
            100                 105                 110         


Gly Glu Arg Pro Ser Gly Ser Ser Tyr Leu Glu Lys Val Gly Leu Val 
        115                 120                 125             


Leu Arg Val Leu Arg Ala Leu Arg Ile Leu Tyr Val Met Arg Leu Ala 
    130                 135                 140                 


Arg His Ser Leu Gly Leu Gln Thr Leu Gly Leu Thr Val Arg Arg Cys 
145                 150                 155                 160 


Thr Arg Glu 
            


<210> 150
<211> 171
<212> PRT
<213> Rattus norvegicus

<400> 150
Trp Ala Leu Phe Glu Asp Pro Tyr Ser Ser Arg Ala Ala Arg Tyr Val 
1               5                   10                  15      


Ala Phe Ala Ser Leu Phe Phe Ile Leu Ile Ser Ile Thr Thr Phe Cys 
            20                  25                  30          


Leu Glu Thr His Glu Gly Phe Ile His Ile Ser Asn Lys Thr Val Thr 
        35                  40                  45              


Gln Ala Ser Pro Ile Pro Gly Ala Pro Pro Glu Asn Ile Thr Asn Val 
    50                  55                  60                  


Glu Val Glu Thr Glu Pro Phe Leu Thr Tyr Val Glu Gly Val Cys Val 
65                  70                  75                  80  


Val Trp Phe Thr Phe Glu Phe Leu Met Arg Val Thr Phe Cys Pro Asp 
                85                  90                  95      


Lys Val Glu Phe Leu Lys Ser Ser Leu Asn Ile Ile Asp Cys Val Ala 
            100                 105                 110         


Ile Leu Pro Phe Tyr Leu Glu Val Gly Leu Ser Gly Leu Ser Ser Lys 
        115                 120                 125             


Ala Ala Lys Asp Val Leu Gly Phe Leu Arg Val Val Arg Phe Val Arg 
    130                 135                 140                 


Ile Leu Arg Ile Phe Lys Leu Thr Arg His Phe Val Gly Leu Arg Val 
145                 150                 155                 160 


Leu Gly His Thr Leu Arg Ala Ser Thr Asn Glu 
                165                 170     


<210> 151
<211> 166
<212> PRT
<213> Homo sapiens

<400> 151
Trp Ala Leu Phe Glu Asp Pro Tyr Ser Ser Arg Ala Ala Arg Phe Ile 
1               5                   10                  15      


Ala Phe Ala Ser Leu Phe Phe Ile Leu Val Ser Ile Thr Thr Phe Cys 
            20                  25                  30          


Leu Glu Thr His Glu Ala Phe Asn Ile Val Lys Asn Lys Thr Glu Pro 
        35                  40                  45              


Val Ile Asn Gly Thr Ser Val Val Leu Gln Tyr Glu Ile Glu Thr Asp 
    50                  55                  60                  


Pro Ala Leu Thr Tyr Val Glu Gly Val Cys Val Val Trp Phe Thr Phe 
65                  70                  75                  80  


Glu Phe Leu Val Arg Ile Val Phe Ser Pro Asn Lys Leu Glu Phe Ile 
                85                  90                  95      


Lys Asn Leu Leu Asn Ile Ile Asp Phe Val Ala Ile Leu Pro Phe Tyr 
            100                 105                 110         


Leu Glu Val Gly Leu Ser Gly Leu Ser Ser Lys Ala Ala Lys Asp Val 
        115                 120                 125             


Leu Gly Phe Leu Arg Val Val Arg Phe Val Arg Ile Leu Arg Ile Phe 
    130                 135                 140                 


Lys Leu Thr Arg His Phe Val Gly Leu Arg Val Leu Gly His Thr Leu 
145                 150                 155                 160 


Arg Ala Ser Thr Asn Glu 
                165     


<210> 152
<211> 168
<212> PRT
<213> Drosophila melanogaster

<400> 152
Trp Ser Leu Phe Asp Glu Pro Tyr Ser Ser Asn Ala Ala Lys Thr Ile 
1               5                   10                  15      


Gly Val Val Ser Val Phe Phe Ile Cys Ile Ser Ile Leu Ser Phe Cys 
            20                  25                  30          


Leu Lys Thr His Pro Asp Met Arg Val Pro Ile Val Arg Asn Ile Thr 
        35                  40                  45              


Val Lys Thr Ala Asn Gly Ser Asn Gly Trp Phe Leu Asp Lys Thr Gln 
    50                  55                  60                  


Thr Asn Ala His Ile Ala Phe Phe Tyr Ile Glu Cys Val Cys Asn Ala 
65                  70                  75                  80  


Trp Phe Thr Phe Glu Ile Leu Val Arg Phe Ile Ser Ser Pro Asn Lys 
                85                  90                  95      


Trp Glu Phe Ile Lys Ser Ser Val Asn Ile Ile Asp Tyr Ile Ala Thr 
            100                 105                 110         


Leu Ser Phe Tyr Ile Asp Leu Val Leu Gln Arg Phe Ala Ser His Leu 
        115                 120                 125             


Glu Asn Ala Asp Ile Leu Glu Phe Phe Ser Ile Ile Arg Ile Met Arg 
    130                 135                 140                 


Leu Phe Lys Leu Thr Arg His Ser Ser Gly Leu Lys Ile Leu Ile Gln 
145                 150                 155                 160 


Thr Phe Arg Ala Ser Ala Lys Glu 
                165             


<210> 153
<211> 172
<212> PRT
<213> Homo sapiens

<400> 153
Trp Leu Leu Phe Glu Tyr Pro Glu Ser Ser Gly Pro Ala Arg Val Ile 
1               5                   10                  15      


Ala Ile Val Ser Val Met Val Ile Leu Ile Ser Ile Val Ile Phe Cys 
            20                  25                  30          


Leu Glu Thr Leu Pro Glu Leu Lys Asp Asp Lys Asp Phe Thr Gly Thr 
        35                  40                  45              


Val His Arg Ile Asp Asn Thr Thr Val Ile Tyr Asn Ser Asn Ile Phe 
    50                  55                  60                  


Thr Asp Pro Phe Phe Ile Val Glu Thr Leu Cys Ile Ile Trp Phe Ser 
65                  70                  75                  80  


Phe Glu Leu Val Val Arg Phe Phe Ala Cys Pro Ser Lys Thr Asp Phe 
                85                  90                  95      


Phe Lys Asn Ile Met Asn Phe Ile Asp Ile Val Ala Ile Ile Pro Tyr 
            100                 105                 110         


Phe Ile Thr Leu Gly Thr Glu Ile Ala Glu Gln Glu Gly Asn Gln Lys 
        115                 120                 125             


Gly Glu Gln Ala Thr Ser Leu Ala Ile Leu Arg Val Ile Arg Leu Val 
    130                 135                 140                 


Arg Val Phe Arg Ile Phe Lys Leu Ser Arg His Ser Lys Gly Leu Gln 
145                 150                 155                 160 


Ile Leu Gly Gln Thr Leu Lys Ala Ser Met Arg Glu 
                165                 170         


<210> 154
<211> 216
<212> PRT
<213> Rattus norvegicus

<400> 154
Trp Leu Leu Phe Glu Tyr Pro Glu Ser Ser Gly Pro Ala Arg Gly Ile 
1               5                   10                  15      


Ala Ile Val Ser Val Leu Val Ile Leu Ile Ser Ile Val Ile Phe Cys 
            20                  25                  30          


Leu Glu Thr Leu Pro Gln Phe Arg Ala Asp Gly Arg Gly Gly Ser Asn 
        35                  40                  45              


Glu Gly Ser Gly Thr Arg Met Ser Pro Ala Ser Arg Gly Ser His Glu 
    50                  55                  60                  


Glu Glu Asp Glu Asp Glu Asp Ser Tyr Ala Phe Pro Gly Ser Ile Pro 
65                  70                  75                  80  


Ser Gly Gly Leu Gly Thr Gly Gly Thr Ser Ser Phe Ser Thr Leu Gly 
                85                  90                  95      


Gly Ser Phe Phe Thr Asp Pro Phe Phe Leu Val Glu Thr Leu Cys Ile 
            100                 105                 110         


Val Trp Phe Thr Phe Glu Leu Leu Val Arg Phe Ser Ala Cys Pro Ser 
        115                 120                 125             


Lys Ala Ala Phe Phe Arg Asn Ile Met Asn Ile Ile Asp Leu Val Ala 
    130                 135                 140                 


Ile Phe Pro Tyr Phe Ile Thr Leu Gly Thr Glu Leu Val Gln Arg His 
145                 150                 155                 160 


Glu Gln Gln Pro Val Ser Gly Gly Ser Gly Gln Asn Arg Gln Gln Ala 
                165                 170                 175     


Met Ser Leu Ala Ile Leu Arg Val Ile Arg Leu Val Arg Val Phe Arg 
            180                 185                 190         


Ile Phe Lys Leu Ser Arg His Ser Lys Gly Leu Gln Ile Leu Gly Lys 
        195                 200                 205             


Thr Leu Gln Ala Ser Met Arg Glu 
    210                 215     


<210> 155
<211> 197
<212> PRT
<213> Homo sapiens

<400> 155
Trp Leu Ile Phe Glu Tyr Pro Glu Ser Ser Gly Ser Ala Arg Ala Ile 
1               5                   10                  15      


Ala Ile Val Ser Val Leu Val Ile Leu Ile Ser Ile Ile Thr Phe Cys 
            20                  25                  30          


Leu Glu Thr Leu Pro Glu Phe Arg Asp Glu Arg Glu Leu Leu Arg His 
        35                  40                  45              


Pro Pro Ala Pro His Gln Pro Pro Ala Pro Ala Pro Gly Ala Asn Gly 
    50                  55                  60                  


Ser Gly Val Met Ala Pro Pro Ser Gly Pro Thr Val Ala Pro Leu Leu 
65                  70                  75                  80  


Pro Arg Thr Leu Ala Asp Pro Phe Phe Ile Val Glu Thr Thr Cys Val 
                85                  90                  95      


Ile Trp Phe Thr Phe Glu Leu Leu Val Arg Phe Phe Ala Cys Pro Ser 
            100                 105                 110         


Lys Ala Gly Phe Ser Arg Asn Ile Met Asn Ile Ile Asp Val Val Ala 
        115                 120                 125             


Ile Phe Pro Tyr Phe Ile Thr Leu Gly Thr Glu Leu Ala Glu Gln Gln 
    130                 135                 140                 


Pro Gly Gly Gly Gly Gly Gly Gln Asn Gly Gln Gln Ala Met Ser Leu 
145                 150                 155                 160 


Ala Ile Leu Arg Val Ile Arg Leu Val Arg Val Phe Arg Ile Phe Lys 
                165                 170                 175     


Leu Ser Arg His Ser Lys Gly Leu Gln Ile Leu Gly Lys Thr Leu Gln 
            180                 185                 190         


Ala Ser Met Arg Glu 
        195         


<210> 156
<211> 177
<212> PRT
<213> Rattus norvegicus

<400> 156
Trp Leu Leu Phe Glu Tyr Pro Glu Ser Ser Gly Pro Ala Arg Gly Ile 
1               5                   10                  15      


Ala Ile Val Ser Val Leu Val Ile Leu Ile Ser Ile Val Ile Phe Cys 
            20                  25                  30          


Leu Glu Thr Leu Pro Glu Phe Arg Asp Glu Lys Asp Tyr Pro Ala Ser 
        35                  40                  45              


Pro Ser Gln Asp Val Phe Glu Ala Ala Asn Asn Ser Thr Ser Gly Ala 
    50                  55                  60                  


Ser Ser Gly Ala Ser Ser Phe Ser Asp Pro Phe Phe Val Val Glu Thr 
65                  70                  75                  80  


Leu Cys Ile Ile Trp Phe Ser Phe Glu Leu Leu Val Arg Phe Phe Ala 
                85                  90                  95      


Cys Pro Ser Lys Ala Thr Phe Ser Arg Asn Ile Met Asn Leu Ile Asp 
            100                 105                 110         


Ile Val Ala Ile Ile Pro Tyr Phe Ile Thr Leu Gly Thr Glu Leu Ala 
        115                 120                 125             


Glu Arg Gln Gly Asn Gly Gln Gln Ala Met Ser Leu Ala Ile Leu Arg 
    130                 135                 140                 


Val Ile Arg Leu Val Arg Val Phe Arg Ile Phe Lys Leu Ser Arg His 
145                 150                 155                 160 


Ser Lys Gly Leu Gln Ile Leu Gly Gln Thr Leu Lys Ala Ser Met Arg 
                165                 170                 175     


Glu 
    


<210> 157
<211> 175
<212> PRT
<213> Canis lupus

<400> 157
Trp Leu Leu Phe Glu Tyr Pro Glu Ser Ser Gly Pro Ala Arg Gly Ile 
1               5                   10                  15      


Ala Ile Val Ser Val Leu Val Ile Leu Val Ser Ile Val Ile Phe Cys 
            20                  25                  30          


Leu Glu Thr Leu Pro Glu Phe Arg Asp Asp Lys Asp Tyr Ala Ala Ala 
        35                  40                  45              


Ala Gln Glu Gln Pro Glu Ala Ala Arg Asn Gly Thr Ser Gly Pro Pro 
    50                  55                  60                  


Ala Ala Ala Gly Phe Ala Asp Pro Phe Phe Val Val Glu Thr Leu Cys 
65                  70                  75                  80  


Ile Ile Trp Phe Ser Phe Glu Leu Leu Val Arg Phe Phe Ala Cys Pro 
                85                  90                  95      


Ser Lys Ala Thr Phe Ser Arg Asn Ile Met Asn Leu Ile Asp Ile Val 
            100                 105                 110         


Ala Ile Ile Pro Tyr Phe Ile Thr Leu Gly Thr Glu Leu Ala Glu Arg 
        115                 120                 125             


Gln Gly Asn Gly Gln Gln Ala Met Ser Leu Ala Ile Leu Arg Val Ile 
    130                 135                 140                 


Arg Leu Val Arg Val Phe Arg Ile Phe Lys Leu Ser Arg His Ser Lys 
145                 150                 155                 160 


Gly Leu Gln Ile Leu Gly Gln Thr Leu Lys Ala Ser Met Arg Glu 
                165                 170                 175 


<210> 158
<211> 184
<212> PRT
<213> Bos taurus

<400> 158
Trp Leu Leu Phe Glu Tyr Pro Glu Ser Ser Ser Pro Ala Arg Gly Ile 
1               5                   10                  15      


Ala Ile Val Ser Val Leu Val Ile Leu Ile Ser Ile Val Ile Phe Cys 
            20                  25                  30          


Leu Glu Thr Leu Pro Glu Phe Arg Asp Asp Arg Asp Leu Ile Met Ala 
        35                  40                  45              


Leu Ser Thr Gly Gly His Gly Gly Leu Leu Asn Asp Thr Ser Ala Pro 
    50                  55                  60                  


His Pro Glu Asn Ser Gly His Thr Ile Phe Asn Asp Pro Phe Phe Ile 
65                  70                  75                  80  


Val Glu Thr Val Cys Ile Val Trp Phe Ser Phe Glu Phe Val Val Arg 
                85                  90                  95      


Cys Phe Ala Cys Pro Ser Gln Ala Leu Phe Phe Lys Asn Ile Met Asn 
            100                 105                 110         


Ile Ile Asp Ile Val Ser Ile Leu Pro Tyr Phe Ile Thr Leu Gly Thr 
        115                 120                 125             


Asp Leu Ala Gln Gln Gln Gly Gly Gly Asn Gly Gln Gln Gln Gln Ala 
    130                 135                 140                 


Met Ser Phe Ala Ile Leu Arg Ile Ile Arg Leu Val Arg Val Phe Arg 
145                 150                 155                 160 


Ile Phe Lys Leu Ser Arg His Ser Lys Gly Leu Gln Ile Leu Gly His 
                165                 170                 175     


Thr Leu Arg Ala Ser Met Arg Glu 
            180                 


<210> 159
<211> 172
<212> PRT
<213> Homo sapiens

<400> 159
Trp Leu Leu Phe Glu Tyr Pro Glu Ser Ser Ser Ala Ala Arg Ala Val 
1               5                   10                  15      


Ala Val Val Ser Val Leu Val Val Val Ile Ser Ile Thr Ile Phe Cys 
            20                  25                  30          


Leu Glu Thr Leu Pro Glu Phe Arg Glu Asp Arg Glu Leu Lys Val Val 
        35                  40                  45              


Arg Asp Pro Asn Leu Asn Met Ser Lys Thr Val Leu Ser Gln Thr Met 
    50                  55                  60                  


Phe Thr Asp Pro Phe Phe Met Val Glu Ser Thr Cys Ile Val Trp Phe 
65                  70                  75                  80  


Thr Phe Glu Leu Val Leu Arg Phe Val Val Cys Pro Ser Lys Thr Asp 
                85                  90                  95      


Phe Phe Arg Asn Ile Met Asn Ile Ile Asp Ile Ile Ser Ile Ile Pro 
            100                 105                 110         


Tyr Phe Ala Thr Leu Ile Thr Glu Leu Val Gln Glu Thr Glu Pro Ser 
        115                 120                 125             


Ala Gln Gln Asn Met Ser Leu Ala Ile Leu Arg Ile Ile Arg Leu Val 
    130                 135                 140                 


Arg Val Phe Arg Ile Phe Lys Leu Ser Arg His Ser Lys Gly Leu Gln 
145                 150                 155                 160 


Ile Leu Gly Gln Thr Leu Lys Ala Ser Met Arg Glu 
                165                 170         


<210> 160
<211> 162
<212> PRT
<213> Rattus norvegicus

<400> 160
Trp Leu Leu Phe Glu Tyr Pro Glu Ser Ser Gly Pro Ala Arg Ile Ile 
1               5                   10                  15      


Ala Ile Val Ser Val Met Val Ile Leu Ile Ser Ile Val Ser Phe Cys 
            20                  25                  30          


Leu Glu Thr Leu Pro Ile Phe Arg Asp Glu Asn Glu Asp Met His Gly 
        35                  40                  45              


Gly Gly Val Thr Phe His Thr Tyr Ser Gln Ser Thr Ile Gly Tyr Gln 
    50                  55                  60                  


Gln Ser Thr Ser Phe Thr Asp Pro Phe Phe Ile Val Glu Thr Leu Cys 
65                  70                  75                  80  


Ile Ile Trp Phe Ser Phe Glu Phe Leu Val Arg Phe Phe Ala Cys Pro 
                85                  90                  95      


Ser Lys Ala Gly Phe Phe Thr Asn Ile Met Asn Ile Ile Asp Ile Val 
            100                 105                 110         


Ala Ile Ile Pro Tyr Tyr Val Thr Ile Phe Leu Thr Glu Ser Asn Lys 
        115                 120                 125             


Ser Val Leu Gln Phe Gln Asn Val Arg Arg Val Val Gln Ile Phe Arg 
    130                 135                 140                 


Ile Met Arg Ile Leu Arg Ile Phe Lys Leu Ser Arg His Ser Lys Gly 
145                 150                 155                 160 


Leu Gln 
        


<210> 161
<211> 178
<212> PRT
<213> Homo sapiens

<400> 161
Trp Leu Leu Phe Glu Tyr Pro Glu Ser Ser Gly Pro Ala Arg Ile Ile 
1               5                   10                  15      


Ala Ile Val Ser Val Met Val Ile Leu Ile Ser Ile Val Ser Phe Cys 
            20                  25                  30          


Leu Glu Thr Leu Pro Ile Phe Arg Asp Glu Asn Glu Asp Met His Gly 
        35                  40                  45              


Ser Gly Val Thr Phe His Thr Tyr Ser Asn Ser Thr Ile Gly Tyr Gln 
    50                  55                  60                  


Gln Ser Thr Ser Phe Thr Asp Pro Phe Phe Ile Val Glu Thr Leu Cys 
65                  70                  75                  80  


Ile Ile Trp Phe Ser Phe Glu Phe Leu Val Arg Phe Phe Ala Cys Pro 
                85                  90                  95      


Ser Lys Ala Gly Phe Phe Thr Asn Ile Met Asn Ile Ile Asp Ile Val 
            100                 105                 110         


Ala Ile Ile Pro Tyr Phe Ile Thr Leu Gly Thr Glu Leu Ala Glu Lys 
        115                 120                 125             


Pro Glu Asp Ala Gln Gln Gly Gln Gln Ala Met Ser Leu Ala Ile Leu 
    130                 135                 140                 


Arg Val Ile Arg Leu Val Arg Val Phe Arg Ile Phe Lys Leu Ser Arg 
145                 150                 155                 160 


His Ser Lys Gly Leu Gln Ile Leu Gly Gln Thr Leu Lys Ala Ser Met 
                165                 170                 175     


Arg Glu 
        


<210> 162
<211> 178
<212> PRT
<213> Rattus norvegicus

<400> 162
Trp Leu Leu Phe Glu Tyr Pro Glu Ser Ser Gly Pro Ala Arg Ile Ile 
1               5                   10                  15      


Ala Ile Val Ser Val Met Val Ile Leu Ile Ser Ile Val Ser Phe Cys 
            20                  25                  30          


Leu Glu Thr Leu Pro Ile Phe Arg Asp Glu Asn Glu Asp Met His Gly 
        35                  40                  45              


Gly Gly Val Thr Phe His Thr Tyr Ser Asn Ser Thr Ile Gly Tyr Gln 
    50                  55                  60                  


Gln Ser Thr Ser Phe Thr Asp Pro Phe Phe Ile Val Glu Thr Leu Cys 
65                  70                  75                  80  


Ile Ile Trp Phe Ser Phe Glu Phe Leu Val Arg Phe Phe Ala Cys Pro 
                85                  90                  95      


Ser Lys Ala Gly Phe Phe Thr Asn Ile Met Asn Ile Ile Asp Ile Val 
            100                 105                 110         


Ala Ile Ile Pro Tyr Phe Ile Thr Leu Gly Thr Glu Leu Ala Glu Lys 
        115                 120                 125             


Pro Glu Asp Ala Gln Gln Gly Gln Gln Ala Met Ser Leu Ala Ile Leu 
    130                 135                 140                 


Arg Val Ile Arg Leu Val Arg Val Phe Arg Ile Phe Lys Leu Ser Arg 
145                 150                 155                 160 


His Ser Lys Gly Leu Gln Ile Leu Gly Gln Thr Leu Lys Ala Ser Met 
                165                 170                 175     


Arg Glu 
        


<210> 163
<211> 178
<212> PRT
<213> Canis lupus

<400> 163
Trp Leu Leu Phe Glu Tyr Pro Glu Ser Ser Gly Pro Ala Arg Ile Ile 
1               5                   10                  15      


Ala Ile Val Ser Val Met Val Ile Leu Ile Ser Ile Val Ser Phe Cys 
            20                  25                  30          


Leu Glu Thr Leu Pro Ile Phe Arg Asp Glu Asn Glu Asp Met His Gly 
        35                  40                  45              


Gly Gly Val Thr Phe His Thr Tyr Ser Asn Ser Thr Ile Gly Tyr Gln 
    50                  55                  60                  


Gln Ser Thr Ser Phe Thr Asp Pro Phe Phe Ile Val Glu Thr Leu Cys 
65                  70                  75                  80  


Ile Ile Trp Phe Ser Phe Glu Phe Leu Val Arg Phe Phe Ala Cys Pro 
                85                  90                  95      


Ser Lys Ala Gly Phe Phe Thr Asn Ile Met Asn Ile Ile Asp Ile Val 
            100                 105                 110         


Ala Ile Ile Pro Tyr Phe Ile Thr Leu Gly Thr Glu Leu Ala Glu Lys 
        115                 120                 125             


Pro Glu Asp Ala Gln Gln Gly Gln Gln Ala Met Ser Leu Ala Ile Leu 
    130                 135                 140                 


Arg Val Ile Arg Leu Val Arg Val Phe Arg Ile Phe Lys Leu Ser Arg 
145                 150                 155                 160 


His Ser Lys Gly Leu Gln Ile Leu Gly Gln Thr Leu Lys Ala Ser Met 
                165                 170                 175     


Arg Glu 
        


<210> 164
<211> 182
<212> PRT
<213> Drosophila melanogaster

<400> 164
Trp Leu Leu Phe Glu Tyr Pro Glu Ser Ser Gln Ala Ala Arg Val Val 
1               5                   10                  15      


Ala Ile Ile Ser Val Phe Val Ile Leu Leu Ser Ile Val Ile Phe Cys 
            20                  25                  30          


Leu Glu Thr Leu Pro Glu Phe Lys His Tyr Lys Val Phe Asn Thr Thr 
        35                  40                  45              


Thr Asn Gly Thr Lys Ile Glu Glu Asp Glu Val Pro Asp Ile Thr Asp 
    50                  55                  60                  


Pro Phe Phe Leu Ile Glu Thr Leu Cys Ile Ile Trp Phe Thr Phe Glu 
65                  70                  75                  80  


Leu Thr Val Arg Phe Leu Ala Cys Pro Asn Lys Leu Asn Phe Cys Arg 
                85                  90                  95      


Asp Val Met Asn Val Ile Asp Ile Ile Ala Ile Ile Pro Tyr Phe Ile 
            100                 105                 110         


Thr Leu Ala Thr Val Val Ala Glu Glu Glu Asp Thr Leu Asn Leu Pro 
        115                 120                 125             


Lys Ala Pro Val Ser Pro Gln Asp Lys Ser Ser Asn Gln Ala Met Ser 
    130                 135                 140                 


Leu Ala Ile Leu Arg Val Ile Arg Leu Val Arg Val Phe Arg Ile Phe 
145                 150                 155                 160 


Lys Leu Ser Arg His Ser Lys Gly Leu Gln Ile Leu Gly Arg Thr Leu 
                165                 170                 175     


Lys Ala Ser Met Arg Glu 
            180         


<210> 165
<211> 151
<212> PRT
<213> Oryctolagus cuniculus

<400> 165
Trp Arg Ala Phe Glu Asn Pro His Thr Ser Thr Leu Ala Leu Val Phe 
1               5                   10                  15      


Tyr Tyr Val Thr Gly Phe Phe Ile Ala Val Ser Val Ile Thr Asn Val 
            20                  25                  30          


Val Glu Thr Val Pro Cys Gly Thr Val Pro Gly Ser Lys Glu Leu Pro 
        35                  40                  45              


Cys Gly Glu Arg Tyr Ser Val Ala Phe Phe Cys Leu Asp Thr Ala Cys 
    50                  55                  60                  


Val Met Ile Phe Thr Val Glu Tyr Leu Leu Arg Leu Phe Ala Ala Pro 
65                  70                  75                  80  


Ser Arg Tyr Arg Phe Ile Arg Ser Val Met Ser Ile Ile Asp Val Val 
                85                  90                  95      


Ala Ile Met Pro Tyr Tyr Ile Gly Leu Val Met Thr Asn Asn Glu Asp 
            100                 105                 110         


Val Ser Gly Ala Phe Val Thr Leu Arg Val Phe Arg Val Phe Arg Ile 
        115                 120                 125             


Phe Lys Phe Ser Arg His Ser Gln Gly Leu Arg Ile Leu Gly Tyr Thr 
    130                 135                 140                 


Leu Lys Ser Cys Ala Ser Glu 
145                 150     


<210> 166
<211> 133
<212> PRT
<213> Homo sapiens

<400> 166
Arg His Met Val Lys Ser Gln Val Phe Tyr Trp Ile Val Leu Ser Leu 
1               5                   10                  15      


Val Ala Leu Asn Thr Ala Cys Val Ala Ile Val His His Asn Gln Pro 
            20                  25                  30          


Gln Trp Leu Thr His Leu Leu Tyr Tyr Ala Glu Phe Leu Phe Leu Gly 
        35                  40                  45              


Leu Phe Leu Leu Glu Met Ser Leu Lys Met Tyr Gly Met Gly Pro Arg 
    50                  55                  60                  


Leu Tyr Phe His Ser Ser Phe Asn Cys Phe Asp Phe Gly Val Thr Val 
65                  70                  75                  80  


Gly Ser Ile Phe Glu Val Val Trp Ala Ile Phe Arg Pro Gly Thr Ser 
                85                  90                  95      


Phe Gly Ile Ser Val Leu Arg Ala Leu Arg Leu Leu Arg Ile Phe Lys 
            100                 105                 110         


Ile Thr Lys Tyr Trp Ala Ser Leu Arg Asn Leu Val Val Ser Leu Met 
        115                 120                 125             


Ser Ser Met Lys Ser 
    130             


<210> 167
<211> 132
<212> PRT
<213> Drosophila melanogaster

<400> 167
Arg His Thr Val Lys Thr Gln Trp Phe Tyr Trp Phe Val Ile Val Leu 
1               5                   10                  15      


Val Phe Leu Asn Thr Val Cys Val Ala Val Glu His Tyr Gly Gln Pro 
            20                  25                  30          


Ser Phe Leu Thr Glu Phe Leu Tyr Tyr Ala Glu Phe Ile Phe Leu Gly 
        35                  40                  45              


Leu Phe Met Ser Glu Met Phe Ile Lys Met Tyr Ala Leu Gly Pro Arg 
    50                  55                  60                  


Ile Tyr Phe Glu Ser Ser Phe Asn Arg Phe Asp Cys Val Val Ile Ser 
65                  70                  75                  80  


Gly Ser Ile Phe Glu Val Ile Trp Ser Glu Val Lys Gly Gly Ser Phe 
                85                  90                  95      


Gly Leu Ser Val Leu Arg Ala Leu Arg Leu Leu Arg Ile Phe Lys Val 
            100                 105                 110         


Thr Lys Tyr Trp Ser Ser Leu Arg Asn Leu Val Ile Ser Leu Leu Asn 
        115                 120                 125             


Ser Met Arg Ser 
    130         


<210> 168
<211> 129
<212> PRT
<213> Mus musculus

<400> 168
Gln Thr Ile Met Thr Asp Pro Phe Thr Glu Leu Ala Ile Thr Ile Cys 
1               5                   10                  15      


Ile Ile Val Asn Thr Val Phe Leu Ala Met Glu His His Asn Met Asp 
            20                  25                  30          


Asn Ser Leu Lys Asp Ile Leu Lys Ile Gly Asn Trp Val Phe Thr Gly 
        35                  40                  45              


Ile Phe Ile Ala Glu Met Cys Leu Lys Ile Ile Ala Leu Asp Pro Tyr 
    50                  55                  60                  


His Tyr Phe Arg His Gly Trp Asn Ile Phe Asp Ser Ile Val Ala Leu 
65                  70                  75                  80  


Val Ser Leu Ala Asp Val Leu Phe His Lys Leu Ser Lys Asn Leu Ser 
                85                  90                  95      


Phe Leu Ala Ser Leu Arg Val Leu Arg Val Phe Lys Leu Ala Lys Ser 
            100                 105                 110         


Trp Pro Thr Leu Asn Thr Leu Ile Lys Ile Ile Gly His Ser Val Gly 
        115                 120                 125             


Ala 
    


<210> 169
<211> 130
<212> PRT
<213> Rattus norvegicus

<400> 169
Arg Thr Ile Met Thr Asp Pro Phe Thr Glu Leu Ala Ile Thr Ile Cys 
1               5                   10                  15      


Ile Ile Ile Asn Thr Val Phe Leu Ala Val Glu His His Asn Met Asp 
            20                  25                  30          


Asp Asn Leu Lys Thr Ile Leu Lys Ile Gly Asn Trp Val Phe Thr Gly 
        35                  40                  45              


Ile Phe Ile Ala Glu Met Cys Leu Lys Ile Ile Ala Leu Asp Pro Tyr 
    50                  55                  60                  


His Tyr Phe Arg His Gly Trp Asn Val Phe Asp Ser Ile Val Ala Leu 
65                  70                  75                  80  


Leu Ser Leu Ala Asp Val Leu Tyr Asn Thr Leu Ser Asp Asn Asn Arg 
                85                  90                  95      


Ser Phe Leu Ala Ser Leu Arg Val Leu Arg Val Phe Lys Leu Ala Lys 
            100                 105                 110         


Ser Trp Pro Thr Leu Asn Thr Leu Ile Lys Ile Ile Gly His Ser Val 
        115                 120                 125             


Gly Ala 
    130 


<210> 170
<211> 128
<212> PRT
<213> Rattus norvegicus

<400> 170
Tyr Phe Ile Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile Cys 
1               5                   10                  15      


Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His His Pro Met Thr 
            20                  25                  30          


Glu Glu Phe Lys Asn Val Leu Ala Val Gly Asn Leu Ile Phe Thr Gly 
        35                  40                  45              


Ile Phe Ala Ala Glu Met Val Leu Lys Leu Ile Ala Met Asp Pro Tyr 
    50                  55                  60                  


Glu Tyr Phe Gln Val Gly Trp Asn Ile Phe Asp Ser Leu Ile Val Thr 
65                  70                  75                  80  


Leu Ser Leu Ile Glu Leu Phe Leu Ala Asp Val Glu Gly Leu Ser Val 
                85                  90                  95      


Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp 
            100                 105                 110         


Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala 
        115                 120                 125             


<210> 171
<211> 147
<212> PRT
<213> Ornithorhynchus anatinus

<400> 171
Trp Gln Val Phe Leu Leu Ser Ala Ser Leu Asn Ser Phe Leu Val Ala 
1               5                   10                  15      


Cys Val Ile Leu Val Val Ile Leu Leu Thr Leu Glu Leu Leu Ile Asp 
            20                  25                  30          


Ile Lys Leu Leu Gln Phe Ser Ser Ala Ser Gln Phe Ala Ser Val Val 
        35                  40                  45              


His Trp Ile Ser Leu Ile Ile Leu Ser Val Phe Phe Thr Glu Thr Ile 
    50                  55                  60                  


Leu Arg Ile Val Val Leu Gly Ile Trp Asp Tyr Ile Glu Asn Lys Ile 
65                  70                  75                  80  


Glu Val Phe Asp Gly Ala Val Ile Ile Leu Ser Leu Ala Pro Met Val 
                85                  90                  95      


Ala Ser Thr Val Ala Asn Gly Pro Ser Ser Pro Trp Asp Ala Ile Ser 
            100                 105                 110         


Leu Ile Ile Thr Leu Arg Ile Trp Arg Val Lys Arg Ile Ile Asp Ala 
        115                 120                 125             


Tyr Val Leu Pro Val Lys Val Glu Met Glu Met Val Ile Gln Gln Tyr 
    130                 135                 140                 


Glu Lys Ala 
145         


<210> 172
<211> 147
<212> PRT
<213> Danio rerio

<400> 172
Trp Gln Val Cys Leu Leu Ser Ala Gly Phe Asn Cys Phe Leu Val Ala 
1               5                   10                  15      


Cys Val Ile Leu Val Val Leu Leu Leu Thr Leu Glu Leu Leu Ile Asp 
            20                  25                  30          


Thr Lys Leu Leu Gln Phe Asn Asn Ala Phe Gln Phe Ala Cys Ile Ile 
        35                  40                  45              


His Trp Ile Ser Leu Val Ile Leu Ser Val Phe Phe Thr Glu Thr Val 
    50                  55                  60                  


Phe Arg Ile Val Val Leu Gly Ile Trp Asp Tyr Ile Glu Asn Lys Val 
65                  70                  75                  80  


Glu Val Phe Asp Gly Ala Val Ile Val Leu Ser Leu Ala Pro Met Val 
                85                  90                  95      


Ala Ser Thr Val Ala Asn Gly Pro Ser Ser Pro Trp Asp Ala Ile Ser 
            100                 105                 110         


Leu Ile Ile Thr Leu Arg Ile Trp Arg Val Lys Arg Ile Ile Asp Ala 
        115                 120                 125             


Tyr Val Leu Gln Val Lys Val Glu Met Glu Leu Glu Ile Gln Gln Tyr 
    130                 135                 140                 


Glu Lys Ser 
145         


<210> 173
<211> 147
<212> PRT
<213> Monodelphis sp.

<400> 173
Trp Gln Val Phe Leu Leu Ser Ala Ser Leu Asn Ser Phe Leu Val Ala 
1               5                   10                  15      


Cys Val Ile Leu Val Val Ile Leu Leu Thr Leu Glu Leu Leu Ile Asp 
            20                  25                  30          


Ile Lys Ser Leu Gln Phe Ser Asn Ser Ser Gln Phe Ala Gly Val Ser 
        35                  40                  45              


His Trp Ile Ser Leu Val Ile Leu Ser Val Phe Phe Ser Glu Thr Ile 
    50                  55                  60                  


Leu Arg Ile Val Val Leu Gly Ile Trp Asp Tyr Ile Glu Asn Lys Ile 
65                  70                  75                  80  


Glu Val Phe Asp Gly Ala Val Ile Ile Leu Ser Leu Ala Pro Met Val 
                85                  90                  95      


Ala Ser Thr Ile Ala Asn Gly Pro Ser Ser Pro Trp Asp Ala Ile Ser 
            100                 105                 110         


Leu Thr Ile Ala Leu Arg Ile Trp Arg Val Lys Arg Ile Ile Asp Ala 
        115                 120                 125             


Tyr Val Leu Pro Val Lys Val Glu Leu Glu Met Val Ile Gln Gln Tyr 
    130                 135                 140                 


Glu Lys Ala 
145         


<210> 174
<211> 147
<212> PRT
<213> Sus scrofa

<400> 174
Trp Gln Val Phe Leu Leu Ser Ala Ser Val Asn Ser Phe Leu Val Ala 
1               5                   10                  15      


Cys Val Ile Leu Val Val Ile Leu Leu Thr Leu Glu Leu Leu Ile Asp 
            20                  25                  30          


Ile Lys Leu Leu Gln Phe Ser Ser Ala Phe Gln Phe Ala Gly Val Ile 
        35                  40                  45              


His Trp Ile Ser Leu Val Ile Leu Ser Val Phe Phe Ser Glu Thr Val 
    50                  55                  60                  


Leu Arg Ile Val Val Leu Gly Ile Trp Asp Tyr Ile Glu Asn Lys Ile 
65                  70                  75                  80  


Glu Val Phe Asp Gly Ala Val Ile Ile Leu Ser Leu Ala Pro Met Val 
                85                  90                  95      


Ala Ser Thr Val Ala Asn Gly Pro Arg Ser Pro Trp Asp Ala Ile Ser 
            100                 105                 110         


Leu Ile Ile Met Leu Arg Ile Trp Arg Val Lys Arg Val Ile Asp Ala 
        115                 120                 125             


Tyr Val Leu Pro Val Lys Val Glu Met Glu Met Val Ile Gln Gln Tyr 
    130                 135                 140                 


Glu Lys Ala 
145         


<210> 175
<211> 147
<212> PRT
<213> Homo sapiens

<400> 175
Trp Gln Val Phe Leu Leu Ser Ala Ser Leu Asn Ser Phe Leu Val Ala 
1               5                   10                  15      


Cys Val Ile Leu Val Val Ile Leu Leu Thr Leu Glu Leu Leu Ile Asp 
            20                  25                  30          


Ile Lys Leu Leu Gln Phe Ser Ser Ala Phe Gln Phe Ala Gly Val Ile 
        35                  40                  45              


His Trp Ile Ser Leu Val Ile Leu Ser Val Phe Phe Ser Glu Thr Val 
    50                  55                  60                  


Leu Arg Ile Val Val Leu Gly Ile Trp Asp Tyr Ile Glu Asn Lys Ile 
65                  70                  75                  80  


Glu Val Phe Asp Gly Ala Val Ile Ile Leu Ser Leu Ala Pro Met Val 
                85                  90                  95      


Ala Ser Thr Val Ala Asn Gly Pro Arg Ser Pro Trp Asp Ala Ile Ser 
            100                 105                 110         


Leu Ile Ile Met Leu Arg Ile Trp Arg Val Lys Arg Val Ile Asp Ala 
        115                 120                 125             


Tyr Val Leu Pro Val Lys Leu Glu Met Glu Met Val Ile Gln Gln Tyr 
    130                 135                 140                 


Glu Lys Ala 
145         


<210> 176
<211> 147
<212> PRT
<213> Pan troglodytes

<400> 176
Trp Gln Val Phe Leu Leu Ser Ala Ser Leu Asn Ser Phe Leu Val Ala 
1               5                   10                  15      


Cys Val Ile Leu Val Val Ile Leu Leu Thr Leu Glu Leu Leu Ile Asp 
            20                  25                  30          


Ile Lys Leu Leu Gln Phe Ser Ser Ala Phe Gln Phe Ala Gly Val Ile 
        35                  40                  45              


His Trp Ile Ser Leu Val Ile Leu Ser Val Phe Phe Ser Glu Thr Val 
    50                  55                  60                  


Leu Arg Ile Val Val Leu Gly Ile Trp Asp Tyr Ile Glu Asn Lys Ile 
65                  70                  75                  80  


Glu Val Phe Asp Gly Ala Val Ile Ile Leu Ser Leu Ala Pro Met Val 
                85                  90                  95      


Ala Ser Thr Val Ala Asn Gly Pro Arg Ser Pro Trp Asp Ala Ile Ser 
            100                 105                 110         


Leu Ile Ile Met Leu Arg Ile Trp Arg Val Lys Arg Val Ile Asp Ala 
        115                 120                 125             


Tyr Val Leu Pro Val Lys Leu Glu Met Glu Met Val Ile Gln Gln Tyr 
    130                 135                 140                 


Glu Lys Ala 
145         


<210> 177
<211> 147
<212> PRT
<213> Equus caballus

<400> 177
Trp Gln Val Phe Leu Leu Ser Ala Ser Leu Asn Ser Phe Leu Val Ala 
1               5                   10                  15      


Cys Val Ile Leu Val Val Ile Leu Leu Thr Leu Glu Leu Leu Ile Asp 
            20                  25                  30          


Ile Lys Leu Leu Gln Phe Ser Ser Ala Phe Gln Phe Ala Gly Val Ile 
        35                  40                  45              


His Trp Ile Ser Leu Val Ile Leu Ser Val Phe Phe Ser Glu Thr Val 
    50                  55                  60                  


Leu Arg Ile Val Val Leu Gly Ile Trp Asp Tyr Ile Glu Asn Lys Ile 
65                  70                  75                  80  


Glu Val Phe Asp Gly Ala Val Ile Ile Leu Ser Leu Ala Pro Met Val 
                85                  90                  95      


Ala Ser Thr Val Ala Asn Gly Pro Arg Ser Pro Trp Asp Ala Ile Ser 
            100                 105                 110         


Leu Ile Ile Met Leu Arg Ile Trp Arg Val Lys Arg Val Ile Asp Ala 
        115                 120                 125             


Tyr Val Leu Pro Val Lys Val Glu Met Glu Met Val Ile Gln Gln Tyr 
    130                 135                 140                 


Glu Lys Ala 
145         


<210> 178
<211> 147
<212> PRT
<213> Mus musculus

<400> 178
Trp Gln Val Phe Leu Leu Ser Ala Ser Leu Asn Ser Phe Leu Val Ala 
1               5                   10                  15      


Cys Val Ile Leu Val Val Ile Leu Leu Thr Leu Glu Leu Leu Ile Asp 
            20                  25                  30          


Thr Lys Leu Leu Gln Phe Ser Asn Ala Phe Gln Phe Ala Gly Val Ile 
        35                  40                  45              


His Trp Ile Ser Leu Val Ile Leu Ser Val Phe Phe Ser Glu Thr Val 
    50                  55                  60                  


Leu Arg Ile Val Val Leu Gly Ile Trp Asp Tyr Ile Glu Asn Lys Ile 
65                  70                  75                  80  


Glu Val Phe Asp Gly Ala Val Ile Ile Leu Ser Leu Ala Pro Met Val 
                85                  90                  95      


Ala Ser Thr Val Ala Asn Gly Pro Arg Ser Pro Trp Asp Ala Ile Ser 
            100                 105                 110         


Leu Ile Ile Met Phe Arg Ile Trp Arg Val Lys Arg Val Ile Asp Ala 
        115                 120                 125             


Tyr Val Leu Pro Val Lys Leu Glu Met Glu Met Val Thr Gln Gln Tyr 
    130                 135                 140                 


Glu Lys Ala 
145         


<210> 179
<211> 147
<212> PRT
<213> Rattus norvegicus

<400> 179
Trp Gln Val Leu Leu Leu Ser Ala Ser Leu Asn Ser Phe Leu Val Ala 
1               5                   10                  15      


Cys Val Ile Leu Val Val Ile Leu Leu Thr Leu Glu Leu Leu Ile Asp 
            20                  25                  30          


Ile Lys Leu Leu Gln Phe Ser Ser Ala Phe Gln Phe Ala Ala Val Ile 
        35                  40                  45              


His Trp Ile Ser Leu Val Ile Leu Ser Val Phe Phe Ser Glu Thr Ile 
    50                  55                  60                  


Leu Arg Ile Val Val Leu Gly Ile Trp Asp Tyr Ile Glu Asn Lys Ile 
65                  70                  75                  80  


Glu Val Phe Asp Gly Ala Val Ile Ile Leu Ser Leu Ala Pro Met Val 
                85                  90                  95      


Ala Ser Thr Val Ala Asn Gly Pro Arg Ser Pro Trp Asp Ala Ile Ser 
            100                 105                 110         


Leu Ile Ile Met Phe Arg Ile Trp Arg Val Lys Arg Val Ile Asp Ala 
        115                 120                 125             


Tyr Val Leu Pro Val Lys Leu Glu Met Glu Met Val Thr Gln Gln Tyr 
    130                 135                 140                 


Glu Lys Ala 
145         


<210> 180
<211> 165
<212> PRT
<213> Ciona intestinalis

<400> 180
Arg Lys Ile Leu His Ser Val Ala Phe Tyr Ile Tyr Ile Leu Ile Ser 
1               5                   10                  15      


Thr Phe Ile Val Thr Leu Leu Leu Leu Ala Glu Leu Leu Ile Asp Val 
            20                  25                  30          


Gly Val Ile Asn Ile Pro Ser Ser Pro Asp Thr Val Val Leu Asn Ala 
        35                  40                  45              


Ser Ala Leu Ser Thr Leu Lys Val Gln Thr Pro Ala Gln Lys Thr Ser 
    50                  55                  60                  


Thr Ile Leu His Trp Ile Ser Phe Ser Phe Leu Ser Leu Phe Phe Ile 
65                  70                  75                  80  


Glu Ile Met Phe Arg Leu Tyr Ala Trp Lys Leu Asn Ile Ile Arg Ser 
                85                  90                  95      


Ile Val Ser Val Phe Asp Cys Ser Ile Val Thr Met Ala Ile Ala Thr 
            100                 105                 110         


Asn Leu Ala Ala Thr Leu Ala Ala Gly Ser Thr Ser Pro Phe Asp Ala 
        115                 120                 125             


Ile Ser Leu Leu Ile Ile Leu Arg Phe Ile Arg Ile His Ser Leu Ile 
    130                 135                 140                 


Gln Arg Cys Val Ser Asp Ser Lys Gln Glu Ile Arg Glu Lys Leu Thr 
145                 150                 155                 160 


Lys Thr Glu Cys Ser 
                165 


<210> 181
<211> 120
<212> PRT
<213> Methanocaldococcus jannaschii

<400> 181
Lys Lys Ile Met Glu Val Leu Ser Leu Ile Phe Thr Phe Glu Ile Val 
1               5                   10                  15      


Ala Ser Phe Ile Leu Ser Thr Tyr Asn Pro Pro Tyr Gln Asp Leu Leu 
            20                  25                  30          


Ile Lys Leu Asp Tyr Ile Ser Ile Met Phe Phe Thr Phe Glu Phe Ile 
        35                  40                  45              


Tyr Asn Phe Tyr Tyr Val Glu Asp Lys Ala Lys Phe Phe Lys Asp Ile 
    50                  55                  60                  


Tyr Asn Ile Val Asp Ala Ile Val Val Ile Ala Phe Leu Leu Tyr Ser 
65                  70                  75                  80  


Leu Gln Val Phe Tyr Ser Lys Ala Phe Leu Gly Leu Arg Val Ile Asn 
                85                  90                  95      


Leu Leu Arg Ile Leu Val Leu Leu Arg Ile Ile Lys Leu Arg Lys Leu 
            100                 105                 110         


Glu Glu Asn Gln Ala Leu Ile Asn 
        115                 120 


<210> 182
<211> 139
<212> PRT
<213> Ornithorhynchus anatinus

<400> 182
Leu Thr Thr Lys Thr Glu Ile Phe Gly Val Ser Leu Ile Phe Val Asp 
1               5                   10                  15      


Val Ala Leu Leu Ile Val Ile Leu Val Thr Thr Ser Lys Ser Ile Arg 
            20                  25                  30          


Ile Pro Phe Ala Tyr Arg Val Val Ser Leu Leu Ile Ala Leu Phe Phe 
        35                  40                  45              


Leu Phe Asp Val Leu Leu Arg Ile Phe Ala Glu Gly Phe Arg Asn Tyr 
    50                  55                  60                  


Phe Ser Ile Lys Leu Asn Ile Leu Asp Ala Phe Ile Val Val Gly Thr 
65                  70                  75                  80  


Leu Met Ile Asp Ile Val Tyr Ile Tyr Val Asn Thr Gly Gly Val Lys 
                85                  90                  95      


Gln Ile Pro Arg Leu Ala Ile Leu Leu Arg Pro Leu Arg Ile Ile Ile 
            100                 105                 110         


Leu Ile Arg Ile Phe Arg Leu Ala Val Gln Lys Lys Gln Leu Glu Lys 
        115                 120                 125             


Val Thr Arg Arg Met Val Ser Glu Asn Lys Arg 
    130                 135                 


<210> 183
<211> 143
<212> PRT
<213> Xenopus tropicalis

<400> 183
Ser Pro Phe Val Met Ser Phe Gly Phe Arg Val Phe Gly Val Val Leu 
1               5                   10                  15      


Ile Ile Val Asp Phe Val Leu Val Ile Val Asp Leu Ser Val Ser Thr 
            20                  25                  30          


Gln Ser Ser Gly Ala Ser Thr Ala Ile Ser Ser Ile Ser Leu Ser Ile 
        35                  40                  45              


Ser Phe Phe Phe Leu Ile Asp Val Leu Leu His Ile Phe Val Glu Gly 
    50                  55                  60                  


Phe Arg Gln Tyr Phe Ser Ser Lys Leu Asn Ile Phe Asp Ala Val Ile 
65                  70                  75                  80  


Val Ile Val Thr Leu Leu Val Thr Leu Val Tyr Ala Phe Thr Asp Phe 
                85                  90                  95      


Ser Gly Ala Ser Asn Ile Pro Arg Met Val Asn Phe Leu Arg Ala Leu 
            100                 105                 110         


Arg Ile Ile Ile Leu Ile Arg Ile Leu Arg Leu Ala Ser Gln Lys Arg 
        115                 120                 125             


Gln Leu Glu Lys Val Thr Arg Arg Leu Val Ser Glu Asn Lys Arg 
    130                 135                 140             


<210> 184
<211> 143
<212> PRT
<213> Gallus gallus

<400> 184
Ser Pro Phe Val Met Ser Phe Gly Phe Arg Val Phe Gly Val Val Leu 
1               5                   10                  15      


Ile Ile Val Asp Ile Ile Val Val Ile Val Asp Leu Ala Ile Ser Glu 
            20                  25                  30          


Lys Lys Arg Gly Ile Arg Glu Ile Leu Glu Gly Val Ser Leu Ala Ile 
        35                  40                  45              


Ala Leu Phe Phe Leu Val Asp Val Leu Met Arg Val Phe Val Glu Gly 
    50                  55                  60                  


Phe Lys Asn Tyr Phe Arg Ser Lys Leu Asn Thr Leu Asp Ala Val Ile 
65                  70                  75                  80  


Val Val Gly Thr Leu Leu Ile Asn Met Thr Tyr Ser Phe Ser Asp Leu 
                85                  90                  95      


Ala Ala Thr Asp Gln Met Pro Arg Met Val Thr Leu Leu Arg Val Leu 
            100                 105                 110         


Arg Ile Val Ile Leu Ile Arg Ile Phe Arg Leu Ala Ser Gln Lys Lys 
        115                 120                 125             


Gln Leu Glu Val Val Thr Arg Arg Met Val Ser Glu Asn Lys Arg 
    130                 135                 140             


<210> 185
<211> 143
<212> PRT
<213> Danio rerio

<400> 185
Thr Pro Phe Val Met Ser Phe Gly Phe Arg Val Phe Gly Leu Val Leu 
1               5                   10                  15      


Ile Ile Leu Asp Ile Ile Met Val Ile Val Asp Leu Ser Leu Ser Glu 
            20                  25                  30          


Lys Ser Arg Asp Val Gly Gly Ala Pro Glu Thr Val Ser Leu Val Ile 
        35                  40                  45              


Ser Phe Phe Phe Leu Ile Asp Val Leu Leu Arg Val Tyr Val Glu Gly 
    50                  55                  60                  


Phe Lys Val Tyr Phe Ser Ser Lys Leu Asn Ile Val Asp Ala Cys Ile 
65                  70                  75                  80  


Val Val Ile Thr Leu Val Val Thr Met Ile Tyr Ala Phe Ser Asp Phe 
                85                  90                  95      


Ser Gly Ala Ser Leu Ile Pro Arg Val Val Thr Phe Leu Arg Ser Leu 
            100                 105                 110         


Arg Ile Leu Ile Leu Val Arg Ile Phe Arg Leu Ala Ser Gln Lys Arg 
        115                 120                 125             


Glu Leu Glu Lys Val Thr Arg Arg Met Val Ser Glu Asn Lys Arg 
    130                 135                 140             


<210> 186
<211> 143
<212> PRT
<213> Xenopus laevis

<400> 186
Ser Pro Phe Val Met Ser Phe Gly Phe Arg Val Phe Gly Val Val Leu 
1               5                   10                  15      


Ile Ile Val Asp Phe Val Leu Val Ile Val Asp Leu Ser Val Ile Asp 
            20                  25                  30          


Lys Ser Arg Glu Ala Thr Thr Ala Ile Ser Ser Ile Ser Leu Ala Ile 
        35                  40                  45              


Ser Phe Phe Phe Leu Ile Asp Val Leu Leu His Ile Phe Val Glu Gly 
    50                  55                  60                  


Phe Arg Gln Tyr Phe Ser Ser Lys Leu Asn Ile Phe Asp Ala Ala Ile 
65                  70                  75                  80  


Val Ile Val Thr Leu Leu Val Thr Leu Val Tyr Ala Phe Thr Asp Phe 
                85                  90                  95      


Ser Gly Ala Thr Asn Ile Pro Arg Leu Val Asn Phe Leu Arg Gly Leu 
            100                 105                 110         


Arg Ile Ile Ile Leu Val Arg Ile Leu Arg Leu Ala Ser Gln Lys Arg 
        115                 120                 125             


Gln Leu Glu Lys Val Thr Arg Arg Leu Val Ser Glu Asn Lys Arg 
    130                 135                 140             


<210> 187
<211> 143
<212> PRT
<213> Rattus norvegicus

<400> 187
His Phe Leu Val Ser Ser Val Ala Phe Arg Ile Phe Gly Ile Leu Leu 
1               5                   10                  15      


Ile Phe Leu Asp Val Phe Leu Val Ala Ile Asp Leu His Ala Thr Glu 
            20                  25                  30          


Lys Asn Ile Tyr Ile Pro Leu Glu Tyr Arg Ala Ile Ser Leu Ala Ile 
        35                  40                  45              


Ala Leu Phe Phe Leu Val Asp Val Leu Leu Arg Val Tyr Val Glu Gly 
    50                  55                  60                  


Arg Gln Arg Tyr Phe Ser Asp Val Leu Asn Thr Leu Asp Ala Val Val 
65                  70                  75                  80  


Ile Gly Val Thr Val Leu Val Ala Val Ile Tyr Thr Leu Tyr Asp Lys 
                85                  90                  95      


Gln Phe Leu Arg Asn Ile Pro Arg Leu Ala Val Leu Leu Arg Pro Leu 
            100                 105                 110         


Arg Leu Leu Ile Leu Val Arg Ile Leu Gln Leu Ala His Gln Lys Arg 
        115                 120                 125             


Gln Leu Glu Lys Leu Thr Arg Gln Leu Val Ser Gly Asn Lys Arg 
    130                 135                 140             


<210> 188
<211> 143
<212> PRT
<213> Mus musculus

<400> 188
Gly Ile Leu Val Ser Ser Val Ala Phe Arg Ile Phe Gly Ile Phe Leu 
1               5                   10                  15      


Val Ile Leu Asp Val Phe Leu Val Val Val Asp Leu Asn Val Ser Glu 
            20                  25                  30          


Lys Lys Ile Tyr Ile Pro Leu Asp Tyr Arg Ser Ile Ser Leu Ala Ile 
        35                  40                  45              


Ala Leu Phe Phe Leu Val Asp Ile Leu Leu Arg Val Ser Val Glu Gly 
    50                  55                  60                  


Arg Arg Arg Tyr Phe Ser Asp Val Leu Asn Thr Leu Asp Ala Val Val 
65                  70                  75                  80  


Ile Gly Val Thr Val Val Val Ala Val Ile Tyr Ala Leu Tyr Asp Lys 
                85                  90                  95      


His Phe Leu Arg Asp Ile Pro Arg Leu Ala Val Leu Leu Arg Pro Leu 
            100                 105                 110         


Arg Leu Leu Ile Leu Ile Arg Ile Leu Gln Leu Ala His Gln Lys Arg 
        115                 120                 125             


Gln Leu Glu Arg Leu Thr Arg Lys Leu Val Ser Gly Asn Lys Arg 
    130                 135                 140             


<210> 189
<211> 147
<212> PRT
<213> Canis lupus

<400> 189
Gly Ser Ser Leu Val Ser Pro Gly His Asn Thr Asn Asn Arg Ile Phe 
1               5                   10                  15      


Gly Ile Leu Leu Ile Phe Val Asp Leu Ser Leu Ile Ile Thr Asp Leu 
            20                  25                  30          


Leu Phe Thr Glu Arg Thr Met His Ile Pro Leu Glu Tyr Arg Ser Ile 
        35                  40                  45              


Ser Leu Ala Ile Ala Leu Phe Phe Phe Phe Asp Val Leu Leu Arg Val 
    50                  55                  60                  


Tyr Val Glu Gly Ile Gln Arg Tyr Phe Ser Asp Ile Leu Asn Tyr Leu 
65                  70                  75                  80  


Asp Ala Val Ile Ile Val Val Thr Leu Leu Ile Asp Ile Ile Tyr Met 
                85                  90                  95      


Phe Tyr Asp Phe Lys Phe Leu Lys Thr Ile Pro Arg Leu Thr Ile Leu 
            100                 105                 110         


Phe Arg Pro Leu Arg Leu Ile Ile Leu Ile Arg Val Phe His Leu Ala 
        115                 120                 125             


His Gln Lys Arg His Leu Glu Met Leu Thr Arg Arg Met Val Ser Gly 
    130                 135                 140                 


Asn Lys Arg 
145         


<210> 190
<211> 143
<212> PRT
<213> Homo sapiens

<400> 190
His Ser Ile Val Ser Ser Phe Ala Phe Gly Ile Phe Gly Val Phe Leu 
1               5                   10                  15      


Val Leu Leu Asp Val Thr Leu Leu Leu Ala Asp Leu Ile Phe Thr Asp 
            20                  25                  30          


Ser Lys Leu Tyr Ile Pro Leu Glu Tyr Arg Ser Ile Ser Leu Ala Ile 
        35                  40                  45              


Gly Leu Phe Phe Leu Met Asp Val Leu Leu Arg Val Phe Val Glu Gly 
    50                  55                  60                  


Arg Gln Gln Tyr Phe Ser Asp Leu Phe Asn Ile Leu Asp Thr Ala Ile 
65                  70                  75                  80  


Ile Val Ile Pro Leu Leu Val Asp Val Ile Tyr Ile Phe Phe Asp Ile 
                85                  90                  95      


Lys Leu Leu Arg Asn Ile Pro Arg Trp Thr His Leu Val Arg Leu Leu 
            100                 105                 110         


Arg Leu Ile Ile Leu Ile Arg Ile Phe His Leu Leu His Gln Lys Arg 
        115                 120                 125             


Gln Leu Glu Lys Leu Met Arg Arg Leu Val Ser Glu Asn Lys Arg 
    130                 135                 140             


<210> 191
<211> 143
<212> PRT
<213> Homo sapiens

<400> 191
His Ser Ile Val Ser Ser Phe Ala Phe Gly Leu Phe Gly Val Phe Leu 
1               5                   10                  15      


Val Leu Leu Asp Val Thr Leu Ile Leu Ala Asp Leu Ile Phe Thr Asp 
            20                  25                  30          


Ser Lys Leu Tyr Ile Pro Leu Glu Tyr Arg Ser Ile Ser Leu Ala Ile 
        35                  40                  45              


Ala Leu Phe Phe Leu Met Asp Val Leu Leu Arg Val Phe Val Glu Arg 
    50                  55                  60                  


Arg Gln Gln Tyr Phe Ser Asp Leu Phe Asn Ile Leu Asp Thr Ala Ile 
65                  70                  75                  80  


Ile Val Ile Leu Leu Leu Val Asp Val Val Tyr Ile Phe Phe Asp Ile 
                85                  90                  95      


Lys Leu Leu Arg Asn Ile Pro Arg Trp Thr His Leu Leu Arg Leu Leu 
            100                 105                 110         


Arg Leu Ile Ile Leu Leu Arg Ile Phe His Leu Phe His Gln Lys Arg 
        115                 120                 125             


Gln Leu Glu Lys Leu Ile Arg Arg Arg Val Ser Glu Asn Lys Arg 
    130                 135                 140             


<210> 192
<211> 141
<212> PRT
<213> Ciona intestinalis

<400> 192
Arg Ala Val Ile Asp His Leu Gly Met Arg Val Phe Gly Val Phe Leu 
1               5                   10                  15      


Ile Phe Leu Asp Ile Ile Leu Met Ile Ile Asp Leu Ser Leu Pro Gly 
            20                  25                  30          


Lys Ser Glu Ser Ser Gln Ser Phe Tyr Asp Gly Met Ala Leu Ala Leu 
        35                  40                  45              


Ser Cys Tyr Phe Met Leu Asp Leu Gly Leu Arg Ile Phe Ala Tyr Gly 
    50                  55                  60                  


Pro Lys Asn Phe Phe Thr Asn Pro Trp Glu Val Ala Asp Gly Leu Ile 
65                  70                  75                  80  


Ile Val Val Thr Phe Val Val Thr Ile Phe Tyr Thr Val Leu Asp Glu 
                85                  90                  95      


Tyr Val Gln Glu Thr Gly Ala Asp Gly Leu Gly Arg Leu Val Val Leu 
            100                 105                 110         


Ala Arg Leu Leu Arg Val Val Arg Leu Ala Arg Ile Phe Tyr Ser His 
        115                 120                 125             


Gln Gln Met Lys Ala Ser Ser Arg Arg Thr Ile Ser Gln 
    130                 135                 140     


<210> 193
<211> 133
<212> PRT
<213> Homo sapiens

<400> 193
Gly Val Met Ile Ser Ala Gln Thr Leu Thr Gly Arg Val Leu Val Val 
1               5                   10                  15      


Leu Val Phe Ala Leu Ser Ile Gly Ala Leu Val Ile Tyr Phe Ile Asp 
            20                  25                  30          


Ser Ser Asn Pro Ile Glu Ser Cys Gln Asn Phe Tyr Lys Asp Phe Thr 
        35                  40                  45              


Leu Gln Ile Asp Met Ala Phe Asn Val Phe Phe Leu Leu Tyr Phe Gly 
    50                  55                  60                  


Leu Arg Phe Ile Ala Ala Asn Asp Lys Leu Trp Phe Trp Leu Glu Val 
65                  70                  75                  80  


Asn Ser Val Val Asp Phe Phe Thr Val Pro Pro Val Phe Val Ser Val 
                85                  90                  95      


Tyr Leu Asn Arg Ser Trp Leu Gly Leu Arg Phe Leu Arg Ala Leu Arg 
            100                 105                 110         


Leu Ile Gln Phe Ser Glu Ile Leu Gln Phe Leu Asn Ile Leu Lys Thr 
        115                 120                 125             


Ser Asn Ser Ile Lys 
    130             


<210> 194
<211> 133
<212> PRT
<213> Mus musculus

<400> 194
Gly Val Met Ile Ser Ala Gln Thr Leu Thr Gly Arg Val Leu Val Val 
1               5                   10                  15      


Leu Val Phe Ala Leu Ser Ile Gly Ala Leu Val Ile Tyr Phe Ile Asp 
            20                  25                  30          


Ser Ser Asn Pro Ile Glu Ser Cys Gln Asn Phe Tyr Lys Asp Phe Thr 
        35                  40                  45              


Leu Gln Ile Asp Met Ala Phe Asn Val Phe Phe Leu Leu Tyr Phe Gly 
    50                  55                  60                  


Leu Arg Phe Ile Ala Ala Asn Asp Lys Leu Trp Phe Trp Leu Glu Val 
65                  70                  75                  80  


Asn Ser Val Val Asp Phe Phe Thr Val Pro Pro Val Phe Val Ser Val 
                85                  90                  95      


Tyr Leu Asn Arg Ser Trp Leu Gly Leu Arg Phe Leu Arg Ala Leu Arg 
            100                 105                 110         


Leu Ile Gln Phe Ser Glu Ile Leu Gln Phe Leu Asn Ile Leu Lys Thr 
        115                 120                 125             


Ser Asn Ser Ile Lys 
    130             


<210> 195
<211> 576
<212> PRT
<213> Ciona intestinalis

<400> 195
Met Glu Gly Phe Asp Gly Ser Asp Phe Ser Pro Pro Ala Asp Leu Val 
1               5                   10                  15      


Gly Val Asp Gly Ala Val Met Arg Asn Val Val Asp Val Thr Ile Asn 
            20                  25                  30          


Gly Asp Val Thr Ala Pro Pro Lys Ala Ala Pro Arg Lys Ser Glu Ser 
        35                  40                  45              


Val Lys Lys Val His Trp Asn Asp Val Asp Gln Gly Pro Ser Glu Lys 
    50                  55                  60                  


Pro Glu Thr Arg Gln Glu Glu Arg Ile Asp Ile Pro Glu Ile Ser Gly 
65                  70                  75                  80  


Leu Trp Trp Gly Glu Asn Glu His Gly Val Asp Asp Gly Arg Met Glu 
                85                  90                  95      


Ile Pro Thr Thr Gly Val Gly Arg Val Gln Phe Arg Val Arg Ala Val 
            100                 105                 110         


Ile Asp His Leu Gly Met Arg Val Phe Gly Val Phe Leu Ile Phe Leu 
        115                 120                 125             


Asp Ile Ile Leu Met Ile Ile Asp Leu Ser Leu Pro Gly Lys Ser Glu 
    130                 135                 140                 


Ser Ser Gln Ser Phe Tyr Asp Gly Met Ala Leu Ala Leu Ser Cys Tyr 
145                 150                 155                 160 


Phe Met Leu Asp Leu Gly Leu Arg Ile Phe Ala Tyr Gly Pro Lys Asn 
                165                 170                 175     


Phe Phe Thr Asn Pro Trp Glu Val Ala Asp Gly Leu Ile Ile Val Val 
            180                 185                 190         


Thr Phe Val Val Thr Ile Phe Tyr Thr Val Leu Asp Glu Tyr Val Gln 
        195                 200                 205             


Glu Thr Gly Ala Asp Gly Leu Gly Arg Leu Val Val Leu Ala Arg Leu 
    210                 215                 220                 


Leu Arg Val Val Arg Leu Ala Arg Ile Phe Tyr Ser His Gln Gln Met 
225                 230                 235                 240 


Lys Ala Ser Ser Arg Arg Thr Ile Ser Gln Asn Lys Arg Arg Tyr Arg 
                245                 250                 255     


Lys Asp Gly Phe Asp Leu Asp Leu Thr Tyr Val Thr Asp His Val Ile 
            260                 265                 270         


Ala Met Ser Phe Pro Ser Ser Gly Arg Gln Ser Leu Phe Arg Asn Pro 
        275                 280                 285             


Ile Gly Glu Val Ser Arg Phe Phe Lys Thr Lys His Pro Asp Lys Phe 
    290                 295                 300                 


Arg Ile Tyr Asn Leu Cys Ser Glu Arg Gly Tyr Asp Glu Thr Lys Phe 
305                 310                 315                 320 


Asp Asn His Val Tyr Arg Val Met Ile Asp Asp His Asn Val Pro Thr 
                325                 330                 335     


Leu Val Asp Leu Leu Lys Phe Ile Asp Asp Ala Lys Val Trp Met Thr 
            340                 345                 350         


Ser Asp Pro Asp His Val Ile Ala Ile His Cys Lys Gly Gly Lys Gly 
        355                 360                 365             


Arg Thr Gly Thr Leu Val Ser Ser Trp Leu Leu Glu Asp Gly Lys Phe 
    370                 375                 380                 


Asp Thr Ala Lys Glu Ala Leu Glu Tyr Phe Gly Ser Arg Arg Thr Asp 
385                 390                 395                 400 


Phe Glu Val Gly Asp Val Phe Gln Gly Val Glu Thr Ala Ser Gln Ile 
                405                 410                 415     


Arg Tyr Val Gly Tyr Phe Glu Lys Ile Lys Lys Asn Tyr Gly Gly Gln 
            420                 425                 430         


Leu Pro Pro Met Lys Lys Leu Lys Val Thr Gly Val Thr Ile Thr Ala 
        435                 440                 445             


Ile Gln Gly Val Gly Arg Gly Asn Gly Ser Asp Leu Ser Met Gln Ile 
    450                 455                 460                 


Val Ser Glu Arg Gln Glu Val Leu Leu Cys Lys Phe Ala Glu Gly Tyr 
465                 470                 475                 480 


Asn Cys Ala Leu Gln Tyr Asp Ala Thr Asp Asp Cys Val Thr Cys Glu 
                485                 490                 495     


Val Lys Asn Cys Pro Val Leu Ala Gly Asp Ile Lys Val Arg Phe Met 
            500                 505                 510         


Ser Thr Ser Lys Ser Leu Pro Arg Gly Tyr Asp Asn Cys Pro Phe Tyr 
        515                 520                 525             


Phe Trp Phe Asn Thr Ser Leu Val Glu Gly Asp His Val Thr Leu Lys 
    530                 535                 540                 


Arg Glu Glu Ile Asp Asn Pro His Lys Lys Lys Thr Trp Lys Ile Tyr 
545                 550                 555                 560 


Arg Asp Asn Phe Thr Val Lys Leu Thr Phe Ser Asp Ala Glu Asp Ile 
                565                 570                 575     


<210> 196
<211> 511
<212> PRT
<213> Danio rerio

<400> 196
Met Thr Ser Val His Phe Asn Pro Gly Leu Asp Ser Lys Glu Val Asn 
1               5                   10                  15      


Gly Asn Ser Val Lys Glu Glu Ala Glu Val Gln Ile Gly Asp Gly Lys 
            20                  25                  30          


Glu Glu Thr Lys Asp Pro Asp Thr Met Tyr His Gln Val Arg Lys Lys 
        35                  40                  45              


Ile Thr Pro Phe Val Met Ser Phe Gly Phe Arg Val Phe Gly Leu Val 
    50                  55                  60                  


Leu Ile Ile Leu Asp Ile Ile Met Val Ile Val Asp Leu Ser Leu Ser 
65                  70                  75                  80  


Glu Lys Ser Arg Asp Val Gly Gly Ala Leu Glu Thr Val Ser Leu Val 
                85                  90                  95      


Ile Ser Phe Phe Phe Leu Ile Asp Val Leu Leu Arg Val Tyr Val Glu 
            100                 105                 110         


Gly Phe Lys Val Tyr Phe Ser Ser Lys Leu Asn Ile Val Asp Ala Cys 
        115                 120                 125             


Ile Val Val Ile Thr Leu Val Val Thr Met Ile Tyr Ala Phe Ser Asp 
    130                 135                 140                 


Phe Ser Gly Ala Ser Leu Ile Pro Arg Val Val Thr Phe Leu Arg Ser 
145                 150                 155                 160 


Leu Arg Ile Leu Ile Leu Val Arg Ile Phe Arg Leu Ala Ser Gln Lys 
                165                 170                 175     


Arg Glu Leu Glu Lys Val Thr Arg Arg Met Val Ser Glu Asn Lys Arg 
            180                 185                 190         


Arg Tyr Gln Lys Asp Gly Phe Asp Leu Asp Leu Thr Tyr Val Thr Glu 
        195                 200                 205             


Arg Val Ile Ala Met Ser Phe Pro Ser Ser Gly Lys Gln Ala Leu Tyr 
    210                 215                 220                 


Arg Asn Pro Ile Arg Glu Val Val Arg Phe Leu Asp Thr Lys His Met 
225                 230                 235                 240 


Asp His Tyr Lys Val Phe Asn Leu Cys Ser Glu Lys Gly Tyr Asp Pro 
                245                 250                 255     


Lys Phe Phe His Tyr Arg Val Glu Arg Val Met Ile Asp Asp His Asn 
            260                 265                 270         


Val Pro Ser Leu Asp Asp Met Leu Arg Tyr Thr Ala Cys Val Arg Asp 
        275                 280                 285             


Trp Met Ala Ala Asp Ser Arg Asn Val Ile Ala Ile His Cys Lys Gly 
    290                 295                 300                 


Gly Lys Gly Arg Thr Gly Thr Met Val Cys Thr Trp Leu Ile Asp Ser 
305                 310                 315                 320 


Asp Gln Phe Glu Ser Ala Gln Glu Ser Leu Asp Tyr Phe Gly Glu Arg 
                325                 330                 335     


Arg Thr Asp Lys Ser Met Ser Ser Lys Phe Gln Gly Val Glu Thr Pro 
            340                 345                 350         


Ser Gln Ser Arg Tyr Val Gly Tyr Tyr Glu Ile Met Lys Asn Gln Tyr 
        355                 360                 365             


Asn Arg Gln Leu Pro Pro Arg Lys Ser Leu Lys Ile Lys Ser Ile Arg 
    370                 375                 380                 


Ile His Ser Ile Ala Gly Val Gly Lys Gly Asn Gly Ser Asp Leu Lys 
385                 390                 395                 400 


Leu Lys Ile Ile Val Lys His Glu Leu Val Phe Gln Cys Val Cys Ala 
                405                 410                 415     


Lys Gln His Asn Cys Thr Val Phe Pro Asp Thr Gly Ser Asn Ala Val 
            420                 425                 430         


Val Ile Ser Leu Gln Asp Gly Pro Ile Val Thr Gly Asp Val Lys Val 
        435                 440                 445             


Met Phe Glu Ser Ser Ala Gly Leu Pro Lys Gly Tyr Glu Asp Cys Pro 
    450                 455                 460                 


Phe Tyr Phe Trp Phe Asn Thr Ser Phe Val Glu Asn Tyr Arg Leu Phe 
465                 470                 475                 480 


Leu Ser Arg Glu Glu Leu Asp Asn Pro His Lys Pro Lys Thr Trp Asp 
                485                 490                 495     


Ile Tyr Lys Glu Asp Phe Gly Val Thr Leu Ser Phe Thr Glu Pro 
            500                 505                 510     


<210> 197
<211> 445
<212> PRT
<213> Homo sapiens

<400> 197
Met Asn Glu Ser Pro Gln Thr Asn Glu Phe Lys Gly Thr Thr Glu Glu 
1               5                   10                  15      


Ala Pro Ala Lys Glu Ser Pro His Thr Ser Glu Phe Lys Gly Ala Ala 
            20                  25                  30          


Leu Val Ser Pro Ile Ser Lys Arg Ile Phe Gly Val Phe Leu Val Leu 
        35                  40                  45              


Leu Asp Val Thr Leu Leu Leu Ala Asp Leu Ile Phe Thr Asp Ser Lys 
    50                  55                  60                  


Leu Tyr Ile Pro Leu Glu Tyr Arg Ser Ile Ser Leu Ala Ile Gly Leu 
65                  70                  75                  80  


Phe Phe Leu Met Asp Val Leu Leu Arg Val Phe Val Glu Gly Trp Thr 
                85                  90                  95      


His Leu Val Arg Leu Leu Arg Leu Ile Ile Leu Ile Arg Ile Phe His 
            100                 105                 110         


Leu Leu His Gln Lys Arg Gln Leu Glu Lys Leu Met Arg Arg Leu Val 
        115                 120                 125             


Ser Glu Asn Lys Arg Arg Tyr Thr Arg Asp Gly Phe Asp Leu Asp Leu 
    130                 135                 140                 


Thr Tyr Val Thr Glu Arg Ile Ile Ala Met Ser Phe Pro Ser Ser Gly 
145                 150                 155                 160 


Arg Gln Ser Phe Tyr Arg Asn Pro Ile Glu Glu Val Val Arg Phe Leu 
                165                 170                 175     


Asp Lys Lys His Arg Asn His Tyr Arg Val Tyr Asn Leu Cys Ser Glu 
            180                 185                 190         


Arg Ala Tyr Asp Pro Lys His Phe His Asn Arg Val Ser Arg Ile Met 
        195                 200                 205             


Ile Asp Asp His Asn Val Pro Thr Leu His Glu Met Val Val Phe Thr 
    210                 215                 220                 


Lys Glu Val Asn Glu Trp Met Ala Gln Asp Leu Glu Asn Ile Val Ala 
225                 230                 235                 240 


Ile His Cys Lys Gly Gly Lys Gly Arg Thr Gly Thr Met Val Cys Ala 
                245                 250                 255     


Leu Leu Ile Ala Ser Glu Ile Phe Leu Thr Ala Glu Glu Ser Leu Tyr 
            260                 265                 270         


Tyr Phe Gly Glu Arg Arg Thr Asn Lys Thr His Ser Asn Lys Phe Gln 
        275                 280                 285             


Gly Val Glu Thr Pro Ser Gln Asn Arg Tyr Val Gly Tyr Phe Ala Gln 
    290                 295                 300                 


Val Lys His Leu Tyr Asn Trp Asn Leu Pro Pro Arg Arg Ile Leu Phe 
305                 310                 315                 320 


Ile Lys Arg Phe Ile Ile Tyr Ser Ile Arg Gly Asp Val Cys Asp Leu 
                325                 330                 335     


Lys Val Gln Val Val Met Glu Lys Lys Val Val Phe Ser Ser Thr Ser 
            340                 345                 350         


Leu Gly Asn Cys Ser Ile Leu His Asp Ile Glu Thr Asp Lys Val Leu 
        355                 360                 365             


Ile Asn Val Tyr Asp Gly Pro Pro Leu Tyr Asp Asp Val Lys Val Gln 
    370                 375                 380                 


Phe Phe Ser Ser Asn Leu Pro Lys Tyr Tyr Asp Asn Cys Pro Phe Phe 
385                 390                 395                 400 


Phe Trp Phe Asn Thr Ser Phe Ile Gln Asn Asn Arg Leu Cys Leu Pro 
                405                 410                 415     


Arg Asn Glu Leu Asp Asn Pro His Lys Gln Lys Ala Trp Lys Ile Tyr 
            420                 425                 430         


Pro Pro Glu Phe Ala Val Glu Ile Leu Phe Gly Lys Lys 
        435                 440                 445 


<210> 198
<211> 522
<212> PRT
<213> Homo sapiens

<400> 198
Met Asn Glu Ser Pro Gln Thr Asn Glu Phe Lys Gly Thr Thr Glu Glu 
1               5                   10                  15      


Ala Pro Ala Lys Glu Ser Pro His Thr Ser Glu Phe Lys Gly Ala Ala 
            20                  25                  30          


Leu Val Ser Pro Ile Ser Lys Ser Met Leu Glu Arg Leu Ser Lys Phe 
        35                  40                  45              


Glu Val Glu Asp Ala Glu Asn Val Ala Ser Tyr Asp Ser Lys Ile Lys 
    50                  55                  60                  


Lys Ile Val His Ser Ile Val Ser Ser Phe Ala Phe Gly Ile Phe Gly 
65                  70                  75                  80  


Val Phe Leu Val Leu Leu Asp Val Thr Leu Leu Leu Ala Asp Leu Ile 
                85                  90                  95      


Phe Thr Asp Ser Lys Leu Tyr Ile Pro Leu Glu Tyr Arg Ser Ile Ser 
            100                 105                 110         


Leu Ala Ile Gly Leu Phe Phe Leu Met Asp Val Leu Leu Arg Val Phe 
        115                 120                 125             


Val Glu Gly Arg Gln Gln Tyr Phe Ser Asp Leu Phe Asn Ile Leu Asp 
    130                 135                 140                 


Thr Ala Ile Ile Val Ile Pro Leu Leu Val Asp Val Ile Tyr Ile Phe 
145                 150                 155                 160 


Phe Asp Ile Lys Leu Leu Arg Asn Ile Pro Arg Trp Thr His Leu Val 
                165                 170                 175     


Arg Leu Leu Arg Leu Ile Ile Leu Ile Arg Ile Phe His Leu Leu His 
            180                 185                 190         


Gln Lys Arg Gln Leu Glu Lys Leu Met Arg Arg Leu Val Ser Glu Asn 
        195                 200                 205             


Lys Arg Arg Tyr Thr Arg Asp Gly Phe Asp Leu Asp Leu Thr Tyr Val 
    210                 215                 220                 


Thr Glu Arg Ile Ile Ala Met Ser Phe Pro Ser Ser Gly Arg Gln Ser 
225                 230                 235                 240 


Phe Tyr Arg Asn Pro Ile Glu Glu Val Val Arg Phe Leu Asp Lys Lys 
                245                 250                 255     


His Arg Asn His Tyr Arg Val Tyr Asn Leu Cys Ser Glu Arg Ala Tyr 
            260                 265                 270         


Asp Pro Lys His Phe His Asn Arg Val Ser Arg Ile Met Ile Asp Asp 
        275                 280                 285             


His Asn Val Pro Thr Leu His Glu Met Val Val Phe Thr Lys Glu Val 
    290                 295                 300                 


Asn Glu Trp Met Ala Gln Asp Leu Glu Asn Ile Val Ala Ile His Cys 
305                 310                 315                 320 


Lys Gly Gly Lys Gly Arg Thr Gly Thr Met Val Cys Ala Leu Leu Ile 
                325                 330                 335     


Ala Ser Glu Ile Phe Leu Thr Ala Glu Glu Ser Leu Tyr Tyr Phe Gly 
            340                 345                 350         


Glu Arg Arg Thr Asn Lys Thr His Ser Asn Lys Phe Gln Gly Val Glu 
        355                 360                 365             


Thr Pro Ser Gln Asn Arg Tyr Val Gly Tyr Phe Ala Gln Val Lys His 
    370                 375                 380                 


Leu Tyr Asn Trp Asn Leu Pro Pro Arg Arg Ile Leu Phe Ile Lys Arg 
385                 390                 395                 400 


Phe Ile Ile Tyr Ser Ile Arg Gly Asp Val Cys Asp Leu Lys Val Gln 
                405                 410                 415     


Val Val Met Glu Lys Lys Val Val Phe Ser Ser Thr Ser Leu Gly Asn 
            420                 425                 430         


Cys Ser Ile Leu His Asp Ile Glu Thr Asp Lys Ile Leu Ile Asn Val 
        435                 440                 445             


Tyr Asp Gly Pro Pro Leu Tyr Asp Asp Val Lys Val Gln Phe Phe Ser 
    450                 455                 460                 


Ser Asn Leu Pro Lys Tyr Tyr Asp Asn Cys Pro Phe Phe Phe Trp Phe 
465                 470                 475                 480 


Asn Thr Ser Phe Ile Gln Asn Asn Arg Leu Cys Leu Pro Arg Asn Glu 
                485                 490                 495     


Leu Asp Asn Pro His Lys Gln Lys Ala Trp Lys Ile Tyr Pro Pro Glu 
            500                 505                 510         


Phe Ala Val Glu Ile Leu Phe Gly Glu Lys 
        515                 520         


<210> 199
<211> 125
<212> PRT
<213> Homo sapiens

<400> 199
Ile Lys Val Leu Ile His Ala Leu Phe Ser Met Phe Ile Met Ile Thr 
1               5                   10                  15      


Ile Leu Thr Asn Cys Val Phe Met Thr Met Ser Asp Pro Pro Pro Trp 
            20                  25                  30          


Ser Lys Asn Val Glu Tyr Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser 
        35                  40                  45              


Leu Ile Lys Ile Leu Ala Arg Gly Phe Cys Val Asp Asp Phe Thr Phe 
    50                  55                  60                  


Leu Arg Asp Pro Trp Asn Trp Leu Asp Phe Ser Val Ile Met Met Ala 
65                  70                  75                  80  


Tyr Leu Thr Glu Phe Val Asp Leu Gly Asn Ile Ser Ala Leu Arg Thr 
                85                  90                  95      


Phe Arg Val Leu Arg Ala Leu Lys Thr Ile Thr Val Ile Pro Gly Leu 
            100                 105                 110         


Lys Thr Ile Val Gly Ala Leu Ile Gln Ser Val Lys Lys 
        115                 120                 125 


<210> 200
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Thr or Ser

<220>
<221> MOD_RES
<222> (2)..(2)
<223> Met, Leu or Gln

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Ile of Val

<400> 200
Xaa Xaa Thr Thr Xaa Gly Tyr Gly 
1               5               


<210> 201
<211> 124
<212> PRT
<213> Aeropyrum sp.

<400> 201
Asp Val Met Glu His Pro Leu Val Glu Leu Gly Val Ser Tyr Ala Ala 
1               5                   10                  15      


Leu Leu Ser Val Ile Val Val Val Val Glu Tyr Thr Met Gln Leu Ser 
            20                  25                  30          


Gly Glu Tyr Leu Val Arg Leu Tyr Leu Val Asp Leu Ile Leu Val Ile 
        35                  40                  45              


Ile Leu Trp Ala Asp Tyr Ala Tyr Arg Ala Tyr Lys Ser Gly Asp Pro 
    50                  55                  60                  


Ala Gly Tyr Val Lys Lys Thr Leu Tyr Glu Ile Pro Ala Leu Val Pro 
65                  70                  75                  80  


Ala Gly Leu Leu Ala Leu Ile Glu Gly His Leu Ala Gly Leu Gly Leu 
                85                  90                  95      


Phe Arg Leu Val Arg Leu Leu Arg Phe Leu Arg Ile Leu Leu Ile Ile 
            100                 105                 110         


Ser Arg Gly Ser Lys Phe Leu Ser Ala Ile Ala Asp 
        115                 120                 


<210> 202
<211> 46
<212> PRT
<213> Homo sapiens

<400> 202
Arg Leu Ser Lys Phe Glu Val Glu Asp Ala Glu Asn Val Ala Ser Tyr 
1               5                   10                  15      


Asp Ser Lys Ile Lys Lys Ile Val His Ser Ile Val Ser Ser Phe Ala 
            20                  25                  30          


Phe Gly Leu Phe Gly Val Phe Leu Val Leu Leu Asp Val Thr 
        35                  40                  45      


<210> 203
<211> 144
<212> PRT
<213> Drosophila melanogaster

<400> 203
Gly Gln His Met Lys Lys Ser Ser Leu Ser Glu Ser Ser Ser Asp Met 
1               5                   10                  15      


Met Asp Leu Asp Asp Gly Val Glu Ser Thr Pro Gly Leu Thr Glu Thr 
            20                  25                  30          


His Pro Gly Arg Ser Ala Val Ala Pro Phe Leu Gly Ala Gln Gln Gln 
        35                  40                  45              


Gln Gln Gln Gln Pro Val Ala Ser Ser Leu Ser Met Ser Ile Asp Lys 
    50                  55                  60                  


Gln Leu Gln His Pro Leu Gln His Val Thr Gln Thr Gln Leu Tyr Gln 
65                  70                  75                  80  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Asn Gly Phe Lys Gln Gln 
                85                  90                  95      


Gln Gln Gln Thr Gln Gln Gln Leu Gln Gln Gln Gln Ser His Thr Ile 
            100                 105                 110         


Asn Ala Ser Ala Ala Ala Ala Thr Ser Gly Ser Gly Ser Ser Gly Leu 
        115                 120                 125             


Thr Met Arg His Asn Asn Ala Leu Ala Val Ser Ile Glu Thr Asp Val 
    130                 135                 140                 


