                               SEQUENCE LISTING

<110> THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
 
<120> NEUTRALIZING ANTIBODY FOR EPSTEIN BARR VIRUS ASSOCIATED DISEASE

<130> 043214-073371-PCT 

<140>
<141>

<150> 61/604,574
<151> 2012-02-29

<160> 53    

<170> PatentIn version 3.5

<210> 1
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Ser Ser Phe Thr Asp Tyr 
            20                  25                  30          


Thr Met Asn Trp Met Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Leu Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Val Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Gly Leu Arg Arg Val Asn Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Ser Val Ser Ala 
        115                 


<210> 2
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ser Ser Thr Leu His Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Gly Asn Tyr Pro His Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210> 3
<211> 106
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Met Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Thr Cys Lys Ala Ser Glu Asn Val Val Thr Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Glu Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Gly Tyr Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105     


<210> 4
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Gln Ala Val Leu Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Val Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp His Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210> 5
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 5
Gly Ser Ser Phe Thr Asp Tyr Thr 
1               5               


<210> 6
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 6
Ile Asn Pro Tyr Asn Gly Gly Thr 
1               5               


<210> 7
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 7
Ala Gly Gly Leu Arg Arg Val Asn Trp Phe Ala Tyr 
1               5                   10          


<210> 8
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 8
Gly Phe Thr Phe Ser Ser Phe Gly 
1               5               


<210> 9
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 9
Ile Ser Ser Gly Ser Ser Thr Leu 
1               5               


<210> 10
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 10
Ala Arg Trp Gly Asn Tyr Pro His Tyr Ala Met Asp Tyr 
1               5                   10              


<210> 11
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 11
Glu Asn Val Val Thr Tyr 
1               5       


<210> 12
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Gly Ala Ser 
1           


<210> 13
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Gly Gln Gly Tyr Ser Tyr Pro Tyr Thr 
1               5                   


<210> 14
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 14
Thr Gly Ala Val Thr Thr Ser Asn Tyr 
1               5                   


<210> 15
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
Gly Thr Asn 
1           


<210> 16
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Val Leu Trp His Ser Asn His Trp Val 
1               5                   


<210> 17
<211> 138
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 17
Met Gly Trp Arg Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Thr Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Ser Ser Phe 
        35                  40                  45              


Thr Asp Tyr Thr Met Asn Trp Met Lys Gln Ser His Gly Lys Asn Leu 
    50                  55                  60                  


Glu Trp Ile Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Arg Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Leu Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Val Leu Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Gly Gly Leu Arg Arg Val Asn Trp Phe Ala Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Ser Val Ser Ala 
    130                 135             


<210> 18
<211> 139
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Met Asp Ser Arg Leu Asn Leu Val Phe Leu Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Phe Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Tyr Ile Ser Ser Gly Ser Ser Thr Leu His Tyr Ala 
65                  70                  75                  80  


Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn 
                85                  90                  95      


Thr Leu Phe Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Trp Gly Asn Tyr Pro His Tyr Ala Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135                 


<210> 19
<211> 127
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 19
Met Glu Ser Gln Thr Leu Val Phe Ile Ser Ile Leu Leu Trp Leu Tyr 
1               5                   10                  15      


Gly Ala Asp Gly Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser 
            20                  25                  30          


Met Ser Val Gly Glu Arg Val Thr Leu Thr Cys Lys Ala Ser Glu Asn 
        35                  40                  45              


Val Val Thr Tyr Val Ser Trp Tyr Gln Gln Lys Pro Glu Gln Ser Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Gly Tyr 
            100                 105                 110         


Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210> 20
<211> 128
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 20
Met Ala Trp Ile Ser Leu Ile Leu Ser Leu Leu Ala Leu Ser Ser Gly 
1               5                   10                  15      


Ala Ile Ser Gln Ala Val Leu Thr Gln Glu Ser Ala Leu Thr Thr Ser 
            20                  25                  30          


Pro Gly Glu Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val 
        35                  40                  45              


Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu 
    50                  55                  60                  


Phe Thr Gly Leu Ile Gly Gly Thr Asn Asn Arg Val Pro Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile 
                85                  90                  95      


Thr Gly Ala Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp 
            100                 105                 110         


His Ser Asn His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        115                 120                 125             


<210> 21
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 21
ctcattcctg ttgaagctgt tgac                                              24


<210> 22
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 22
tatgcaaggc ttacaaccac a                                                 21


<210> 23
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 23
acactctgca ggagacagac tcttttc                                           27


<210> 24
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 24
acactcagca cgggacaaac tcttctc                                           27


<210> 25
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 25
caattttctt gtccaccttg gtgctgc                                           27


<210> 26
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 26
ctcattcctg ttgaagctct tgacaatggg                                        30


<210> 27
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 27
acactcagca cgggacaaac tcttctccac agt                                    33


<210> 28
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 28
acactctgca ggagacagac tcttttccac agt                                    33


<210> 29
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 29
acactcagca cgggacaaac tcttctccac agt                                    33


<210> 30
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 30
gactcgagtc gacatcgatt tttttttttt ttttt                                  35


<210> 31
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 31
cactgactcg aattcatggg atggaggtgg                                        30


<210> 32
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 32
cacagaccag aattcatgga ctccaggctc                                        30


<210> 33
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 33
ggtgtcgtcg tacgtgcaga gacagagacc                                        30


<210> 34
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 34
ggtgtcgtcg tacgtgagga gacggtgac                                         29


<210> 35
<211> 32
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 35
cctggtttgt gaattcatgg cctggatttc ac                                     32


<210> 36
<211> 31
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 36
gacttgggcg tacgtaggac agtcagtttg g                                      31


<210> 37
<211> 31
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 37
ccagcatgga attcaagatg gaatcacaga c                                      31


<210> 38
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 38
ggtgcagcat ccgtacgttt tatttccagc                                        30


<210> 39
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 39
ggcaaggagt acaagtgc                                                     18


<210> 40
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 40
gcacggtcac cacgctgc                                                     18


<210> 41
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 41
ggtgtacacc tgtggttc                                                     18


<210> 42
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 42
cgaactgtgg ctgcacc                                                      17


<210> 43
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 43
cctgatgggt gacttcg                                                      17


<210> 44
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (3)..(3)
<223> a, t, c, or g

<220>
<221> modified_base
<222> (6)..(6)
<223> a, t, c, or g

<220>
<221> modified_base
<222> (9)..(9)
<223> a, t, c, or g

<220>
<221> modified_base
<222> (15)..(15)
<223> a, t, c, or g

<220>
<221> modified_base
<222> (24)..(24)
<223> a, t, c, or g

<400> 44
ggnwsnwsnt tyacngayta yacn                                              24


<210> 45
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (9)..(9)
<223> a, t, c, or g

<220>
<221> modified_base
<222> (18)..(18)
<223> a, t, c, or g

<220>
<221> modified_base
<222> (21)..(21)
<223> a, t, c, or g

<220>
<221> modified_base
<222> (24)..(24)
<223> a, t, c, or g

<400> 45
athaayccnt ayaayggngg nacn                                              24


<210> 46
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (3)..(3)
<223> a, t, c, or g

<220>
<221> modified_base
<222> (6)..(6)
<223> a, t, c, or g

<220>
<221> modified_base
<222> (9)..(9)
<223> a, t, c, or g

<220>
<221> modified_base
<222> (12)..(12)
<223> a, t, c, or g

<220>
<221> modified_base
<222> (15)..(15)
<223> a, t, c, or g

<220>
<221> modified_base
<222> (18)..(18)
<223> a, t, c, or g

<220>
<221> modified_base
<222> (21)..(21)
<223> a, t, c, or g

<220>
<221> modified_base
<222> (33)..(33)
<223> a, t, c, or g

<400> 46
gcnggnggny tnmgnmgngt naaytggtty gcntay                                 36


<210> 47
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (3)..(3)
<223> a, t, c, or g

<220>
<221> modified_base
<222> (6)..(6)
<223> a, t, c, or g

<220>
<221> modified_base
<222> (9)..(9)
<223> a, t, c, or g

<220>
<221> modified_base
<222> (12)..(12)
<223> a, t, c, or g

<220>
<221> modified_base
<222> (15)..(15)
<223> a, t, c, or g

<220>
<221> modified_base
<222> (18)..(18)
<223> a, t, c, or g

<220>
<221> modified_base
<222> (21)..(21)
<223> a, t, c, or g

<400> 47
acnggngcng tnacnacnws naaytay                                           27


<210> 48
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (3)..(3)
<223> a, t, c, or g

<220>
<221> modified_base
<222> (6)..(6)
<223> a, t, c, or g

<400> 48
ggnacnaay                                                                9


<210> 49
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (3)..(3)
<223> a, t, c, or g

<220>
<221> modified_base
<222> (6)..(6)
<223> a, t, c, or g

<220>
<221> modified_base
<222> (15)..(15)
<223> a, t, c, or g

<220>
<221> modified_base
<222> (27)..(27)
<223> a, t, c, or g

<400> 49
gtnytntggc aywsnaayca ytgggtn                                           27


<210> 50
<211> 483
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 50
Met Gly Trp Arg Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Thr Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Ser Ser Phe 
        35                  40                  45              


Thr Asp Tyr Thr Met Asn Trp Met Lys Gln Ser His Gly Lys Asn Leu 
    50                  55                  60                  


Glu Trp Ile Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Arg Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Leu Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Val Leu Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Gly Gly Leu Arg Arg Val Asn Trp Phe Ala Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Ser Val Ser Ala Ala Lys Thr Thr Pro Pro 
    130                 135                 140                 


Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met 
145                 150                 155                 160 


Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val 
        195                 200                 205             


Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His 
    210                 215                 220                 


Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys 
225                 230                 235                 240 


Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe 
                245                 250                 255     


Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro 
            260                 265                 270         


Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val 
        275                 280                 285             


Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr 
    290                 295                 300                 


Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu 
305                 310                 315                 320 


Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys 
                325                 330                 335     


Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro 
        355                 360                 365             


Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile 
    370                 375                 380                 


Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly 
385                 390                 395                 400 


Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp 
                405                 410                 415     


Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp 
            420                 425                 430         


Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His 
        435                 440                 445             


Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Ile Cys Pro 
    450                 455                 460                 


Trp Ser Pro Leu Val Leu Gln Asp Ser Asp Thr Tyr Leu His Pro Ser 
465                 470                 475                 480 


Leu Cys Lys 
            


<210> 51
<211> 484
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 51
Met Asp Ser Arg Leu Asn Leu Val Phe Leu Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Phe Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Tyr Ile Ser Ser Gly Ser Ser Thr Leu His Tyr Ala 
65                  70                  75                  80  


Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn 
                85                  90                  95      


Thr Leu Phe Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Trp Gly Asn Tyr Pro His Tyr Ala Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro 
    130                 135                 140                 


Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser 
145                 150                 155                 160 


Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr 
        195                 200                 205             


Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala 
    210                 215                 220                 


His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp 
225                 230                 235                 240 


Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val 
                245                 250                 255     


Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr 
            260                 265                 270         


Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu 
        275                 280                 285             


Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln 
    290                 295                 300                 


Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser 
305                 310                 315                 320 


Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys 
                325                 330                 335     


Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro 
        355                 360                 365             


Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met 
    370                 375                 380                 


Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn 
385                 390                 395                 400 


Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr 
                405                 410                 415     


Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn 
            420                 425                 430         


Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu 
        435                 440                 445             


His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Ile Cys 
    450                 455                 460                 


Pro Trp Ser Pro Leu Val Leu Gln Asp Ser Asp Thr Tyr Leu His Pro 
465                 470                 475                 480 


Ser Leu Cys Lys 
                


<210> 52
<211> 218
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 52
Gly Ala Asp Gly Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser 
1               5                   10                  15      


Met Ser Val Gly Glu Arg Val Thr Leu Thr Cys Lys Ala Ser Glu Asn 
            20                  25                  30          


Val Val Thr Tyr Val Ser Trp Tyr Gln Gln Lys Pro Glu Gln Ser Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Thr Gly Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Gly Tyr 
                85                  90                  95      


Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
        115                 120                 125             


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln 
145                 150                 155                 160 


Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg 
            180                 185                 190         


His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro 
        195                 200                 205             


Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
    210                 215             


<210> 53
<211> 218
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 53
Gly Ala Ile Ser Gln Ala Val Leu Thr Gln Glu Ser Ala Leu Thr Thr 
1               5                   10                  15      


Ser Pro Gly Glu Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala 
            20                  25                  30          


Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His 
        35                  40                  45              


Leu Phe Thr Gly Leu Ile Gly Gly Thr Asn Asn Arg Val Pro Gly Val 
    50                  55                  60                  


Pro Ala Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr 
65                  70                  75                  80  


Ile Thr Gly Ala Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu 
                85                  90                  95      


Trp His Ser Asn His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
            100                 105                 110         


Leu Gly Gln Pro Lys Ser Ser Pro Ser Val Thr Leu Phe Pro Pro Ser 
        115                 120                 125             


Ser Glu Glu Leu Glu Thr Asn Lys Ala Thr Leu Val Cys Thr Ile Thr 
    130                 135                 140                 


Asp Phe Tyr Pro Gly Val Val Thr Val Asp Trp Lys Val Asp Gly Thr 
145                 150                 155                 160 


Pro Val Thr Gln Gly Met Gly Thr Thr Gln Pro Ser Lys Gln Ser Asn 
                165                 170                 175     


Asn Lys Tyr Met Ala Ser Ser Tyr Leu Thr Leu Thr Ala Arg Ala Trp 
            180                 185                 190         


Glu Arg His Ser Ser Tyr Ser Cys Gln Val Thr His Glu Gly His Thr 
        195                 200                 205             


Val Glu Lys Ser Leu Ser Arg Ala Asp Cys 
    210                 215             


