                         SEQUENCE LISTING

<110>  Duke University
       Reitman, Zachary
       Yan, Hai
       Choi, Bryan
       Sampson, John
 
<120>  NOVEL OXIDOREDUCTASES FOR ENANTIOSELECTIVE REACTIONS

<130>  D118 1090 WO

<150>  US61604630
<151>  2012-02-29

<160>  173   

<170>  PatentIn version 3.5

<210>  1
<211>  1113
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  1
atgtttagat ctgttgctac tagattatct gcctgccgtg ggttagcatc taacgctgct       60

cgcaaatcac tcactattgg tcttatcccc ggtgacggta tcggtaagga agtcattcct      120

gctggtaagc aagttttgga aaaccttaac tccaagcacg gcctaagctt caactttatt      180

gatctctacg ccggtttcca aacattccaa gaaacaggaa aggcgttgcc tgatgagact      240

gttaaagtgt tgaaggaaca atgtcaaggt gctcttttcg gtgcagttca gtctccaact      300

actaaggtgg aaggttactc ctcaccaatt gttgctctaa ggagggaaat gggccttttc      360

gctaatgttc gtcctgttaa gtctgtagag ggagaaaagg gtaaaccaat tgacatggtt      420

atcgtcagag aaaatactga ggacctgtac attaaaattg aaaaaacata cattgacaag      480

gccacaggta caagagttgc tgatgccaca aagagaatat ccgaaattgc aacaagaaga      540

attgcaacca ttgcattaga tattgccttg aaaagattac aaacaagagg ccaagccact      600

ttgacagtga ctcataaatc aaatgttcta tctcaaagtg atggtctatt cagagaaatc      660

tgtaaggaag tctacgaatc taacaaggac aagtacggtc aaatcaaata taacgaacaa      720

attgtggatt ccatggttta taggctgttc agagaaccac aatgttttga tgtgatagtg      780

gcaccaaacc tatacgggga tatattatct gacggtgctg ctgctttagt cggttcatta      840

ggtgttgttc caagcgccaa cgtaggtcca gaaattgtca ttggtgaacc atgccatggt      900

tctgcaccag atattgctgg taaaggtatt gctaacccaa tcgccactat aagatctact      960

gctttgatgt tggaattctt gggccacaac gaagctgccc aagatatcta caaggctgtt     1020

gatgctaact taagagaggg ttctatcaag acaccagatt taggtggtaa ggcttctact     1080

caacaagtcg ttgacgacgt tttgtcgaga tta                                  1113


<210>  2
<211>  371
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  2

Met Phe Arg Ser Val Ala Thr Arg Leu Ser Ala Cys Arg Gly Leu Ala 
1               5                   10                  15      


Ser Asn Ala Ala Arg Lys Ser Leu Thr Ile Gly Leu Ile Pro Gly Asp 
            20                  25                  30          


Gly Ile Gly Lys Glu Val Ile Pro Ala Gly Lys Gln Val Leu Glu Asn 
        35                  40                  45              


Leu Asn Ser Lys His Gly Leu Ser Phe Asn Phe Ile Asp Leu Tyr Ala 
    50                  55                  60                  


Gly Phe Gln Thr Phe Gln Glu Thr Gly Lys Ala Leu Pro Asp Glu Thr 
65                  70                  75                  80  


Val Lys Val Leu Lys Glu Gln Cys Gln Gly Ala Leu Phe Gly Ala Val 
                85                  90                  95      


Gln Ser Pro Thr Thr Lys Val Glu Gly Tyr Ser Ser Pro Ile Val Ala 
            100                 105                 110         


Leu Arg Arg Glu Met Gly Leu Phe Ala Asn Val Arg Pro Val Lys Ser 
        115                 120                 125             


Val Glu Gly Glu Lys Gly Lys Pro Ile Asp Met Val Ile Val Arg Glu 
    130                 135                 140                 


Asn Thr Glu Asp Leu Tyr Ile Lys Ile Glu Lys Thr Tyr Ile Asp Lys 
145                 150                 155                 160 


Ala Thr Gly Thr Arg Val Ala Asp Ala Thr Lys Arg Ile Ser Glu Ile 
                165                 170                 175     


Ala Thr Arg Arg Ile Ala Thr Ile Ala Leu Asp Ile Ala Leu Lys Arg 
            180                 185                 190         


Leu Gln Thr Arg Gly Gln Ala Thr Leu Thr Val Thr His Lys Ser Asn 
        195                 200                 205             


Val Leu Ser Gln Ser Asp Gly Leu Phe Arg Glu Ile Cys Lys Glu Val 
    210                 215                 220                 


Tyr Glu Ser Asn Lys Asp Lys Tyr Gly Gln Ile Lys Tyr Asn Glu Gln 
225                 230                 235                 240 


Ile Val Asp Ser Met Val Tyr Arg Leu Phe Arg Glu Pro Gln Cys Phe 
                245                 250                 255     


Asp Val Ile Val Ala Pro Asn Leu Tyr Gly Asp Ile Leu Ser Asp Gly 
            260                 265                 270         


Ala Ala Ala Leu Val Gly Ser Leu Gly Val Val Pro Ser Ala Asn Val 
        275                 280                 285             


Gly Pro Glu Ile Val Ile Gly Glu Pro Cys His Gly Ser Ala Pro Asp 
    290                 295                 300                 


Ile Ala Gly Lys Gly Ile Ala Asn Pro Ile Ala Thr Ile Arg Ser Thr 
305                 310                 315                 320 


Ala Leu Met Leu Glu Phe Leu Gly His Asn Glu Ala Ala Gln Asp Ile 
                325                 330                 335     


Tyr Lys Ala Val Asp Ala Asn Leu Arg Glu Gly Ser Ile Lys Thr Pro 
            340                 345                 350         


Asp Leu Gly Gly Lys Ala Ser Thr Gln Gln Val Val Asp Asp Val Leu 
        355                 360                 365             


Ser Arg Leu 
    370     


<210>  3
<211>  1113
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ScHIDH V111D polynucleotide

<400>  3
atgtttagat ctgttgctac tagattatct gcctgccgtg ggttagcatc taacgctgct       60

cgcaaatcac tcactattgg tcttatcccc ggtgacggta tcggtaagga agtcattcct      120

gctggtaagc aagttttgga aaaccttaac tccaagcacg gcctaagctt caactttatt      180

gatctctacg ccggtttcca aacattccaa gaaacaggaa aggcgttgcc tgatgagact      240

gttaaagtgt tgaaggaaca atgtcaaggt gctcttttcg gtgcagttca gtctccaact      300

actaaggtgg aaggttactc ctcaccaatt gatgctctaa ggagggaaat gggccttttc      360

gctaatgttc gtcctgttaa gtctgtagag ggagaaaagg gtaaaccaat tgacatggtt      420

atcgtcagag aaaatactga ggacctgtac attaaaattg aaaaaacata cattgacaag      480

gccacaggta caagagttgc tgatgccaca aagagaatat ccgaaattgc aacaagaaga      540

attgcaacca ttgcattaga tattgccttg aaaagattac aaacaagagg ccaagccact      600

ttgacagtga ctcataaatc aaatgttcta tctcaaagtg atggtctatt cagagaaatc      660

tgtaaggaag tctacgaatc taacaaggac aagtacggtc aaatcaaata taacgaacaa      720

attgtggatt ccatggttta taggctgttc agagaaccac aatgttttga tgtgatagtg      780

gcaccaaacc tatacgggga tatattatct gacggtgctg ctgctttagt cggttcatta      840

ggtgttgttc caagcgccaa cgtaggtcca gaaattgtca ttggtgaacc atgccatggt      900

tctgcaccag atattgctgg taaaggtatt gctaacccaa tcgccactat aagatctact      960

gctttgatgt tggaattctt gggccacaac gaagctgccc aagatatcta caaggctgtt     1020

gatgctaact taagagaggg ttctatcaag acaccagatt taggtggtaa ggcttctact     1080

caacaagtcg ttgacgacgt tttgtcgaga tta                                  1113


<210>  4
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ScHIDH V111D polypeptide

<400>  4

Met Phe Arg Ser Val Ala Thr Arg Leu Ser Ala Cys Arg Gly Leu Ala 
1               5                   10                  15      


Ser Asn Ala Ala Arg Lys Ser Leu Thr Ile Gly Leu Ile Pro Gly Asp 
            20                  25                  30          


Gly Ile Gly Lys Glu Val Ile Pro Ala Gly Lys Gln Val Leu Glu Asn 
        35                  40                  45              


Leu Asn Ser Lys His Gly Leu Ser Phe Asn Phe Ile Asp Leu Tyr Ala 
    50                  55                  60                  


Gly Phe Gln Thr Phe Gln Glu Thr Gly Lys Ala Leu Pro Asp Glu Thr 
65                  70                  75                  80  


Val Lys Val Leu Lys Glu Gln Cys Gln Gly Ala Leu Phe Gly Ala Val 
                85                  90                  95      


Gln Ser Pro Thr Thr Lys Val Glu Gly Tyr Ser Ser Pro Ile Asp Ala 
            100                 105                 110         


Leu Arg Arg Glu Met Gly Leu Phe Ala Asn Val Arg Pro Val Lys Ser 
        115                 120                 125             


Val Glu Gly Glu Lys Gly Lys Pro Ile Asp Met Val Ile Val Arg Glu 
    130                 135                 140                 


Asn Thr Glu Asp Leu Tyr Ile Lys Ile Glu Lys Thr Tyr Ile Asp Lys 
145                 150                 155                 160 


Ala Thr Gly Thr Arg Val Ala Asp Ala Thr Lys Arg Ile Ser Glu Ile 
                165                 170                 175     


Ala Thr Arg Arg Ile Ala Thr Ile Ala Leu Asp Ile Ala Leu Lys Arg 
            180                 185                 190         


Leu Gln Thr Arg Gly Gln Ala Thr Leu Thr Val Thr His Lys Ser Asn 
        195                 200                 205             


Val Leu Ser Gln Ser Asp Gly Leu Phe Arg Glu Ile Cys Lys Glu Val 
    210                 215                 220                 


Tyr Glu Ser Asn Lys Asp Lys Tyr Gly Gln Ile Lys Tyr Asn Glu Gln 
225                 230                 235                 240 


Ile Val Asp Ser Met Val Tyr Arg Leu Phe Arg Glu Pro Gln Cys Phe 
                245                 250                 255     


Asp Val Ile Val Ala Pro Asn Leu Tyr Gly Asp Ile Leu Ser Asp Gly 
            260                 265                 270         


Ala Ala Ala Leu Val Gly Ser Leu Gly Val Val Pro Ser Ala Asn Val 
        275                 280                 285             


Gly Pro Glu Ile Val Ile Gly Glu Pro Cys His Gly Ser Ala Pro Asp 
    290                 295                 300                 


Ile Ala Gly Lys Gly Ile Ala Asn Pro Ile Ala Thr Ile Arg Ser Thr 
305                 310                 315                 320 


Ala Leu Met Leu Glu Phe Leu Gly His Asn Glu Ala Ala Gln Asp Ile 
                325                 330                 335     


Tyr Lys Ala Val Asp Ala Asn Leu Arg Glu Gly Ser Ile Lys Thr Pro 
            340                 345                 350         


Asp Leu Gly Gly Lys Ala Ser Thr Gln Gln Val Val Asp Asp Val Leu 
        355                 360                 365             


Ser Arg Leu 
    370     


<210>  5
<211>  1113
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ScHIDH R114Q polynucleotide

<400>  5
atgtttagat ctgttgctac tagattatct gcctgccgtg ggttagcatc taacgctgct       60

cgcaaatcac tcactattgg tcttatcccc ggtgacggta tcggtaagga agtcattcct      120

gctggtaagc aagttttgga aaaccttaac tccaagcacg gcctaagctt caactttatt      180

gatctctacg ccggtttcca aacattccaa gaaacaggaa aggcgttgcc tgatgagact      240

gttaaagtgt tgaaggaaca atgtcaaggt gctcttttcg gtgcagttca gtctccaact      300

actaaggtgg aaggttactc ctcaccaatt gttgctctac agagggaaat gggccttttc      360

gctaatgttc gtcctgttaa gtctgtagag ggagaaaagg gtaaaccaat tgacatggtt      420

atcgtcagag aaaatactga ggacctgtac attaaaattg aaaaaacata cattgacaag      480

gccacaggta caagagttgc tgatgccaca aagagaatat ccgaaattgc aacaagaaga      540

attgcaacca ttgcattaga tattgccttg aaaagattac aaacaagagg ccaagccact      600

ttgacagtga ctcataaatc aaatgttcta tctcaaagtg atggtctatt cagagaaatc      660

tgtaaggaag tctacgaatc taacaaggac aagtacggtc aaatcaaata taacgaacaa      720

attgtggatt ccatggttta taggctgttc agagaaccac aatgttttga tgtgatagtg      780

gcaccaaacc tatacgggga tatattatct gacggtgctg ctgctttagt cggttcatta      840

ggtgttgttc caagcgccaa cgtaggtcca gaaattgtca ttggtgaacc atgccatggt      900

tctgcaccag atattgctgg taaaggtatt gctaacccaa tcgccactat aagatctact      960

gctttgatgt tggaattctt gggccacaac gaagctgccc aagatatcta caaggctgtt     1020

gatgctaact taagagaggg ttctatcaag acaccagatt taggtggtaa ggcttctact     1080

caacaagtcg ttgacgacgt tttgtcgaga tta                                  1113


<210>  6
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ScHIDH R114Q polypeptide

<400>  6

Met Phe Arg Ser Val Ala Thr Arg Leu Ser Ala Cys Arg Gly Leu Ala 
1               5                   10                  15      


Ser Asn Ala Ala Arg Lys Ser Leu Thr Ile Gly Leu Ile Pro Gly Asp 
            20                  25                  30          


Gly Ile Gly Lys Glu Val Ile Pro Ala Gly Lys Gln Val Leu Glu Asn 
        35                  40                  45              


Leu Asn Ser Lys His Gly Leu Ser Phe Asn Phe Ile Asp Leu Tyr Ala 
    50                  55                  60                  


Gly Phe Gln Thr Phe Gln Glu Thr Gly Lys Ala Leu Pro Asp Glu Thr 
65                  70                  75                  80  


Val Lys Val Leu Lys Glu Gln Cys Gln Gly Ala Leu Phe Gly Ala Val 
                85                  90                  95      


Gln Ser Pro Thr Thr Lys Val Glu Gly Tyr Ser Ser Pro Ile Val Ala 
            100                 105                 110         


Leu Gln Arg Glu Met Gly Leu Phe Ala Asn Val Arg Pro Val Lys Ser 
        115                 120                 125             


Val Glu Gly Glu Lys Gly Lys Pro Ile Asp Met Val Ile Val Arg Glu 
    130                 135                 140                 


Asn Thr Glu Asp Leu Tyr Ile Lys Ile Glu Lys Thr Tyr Ile Asp Lys 
145                 150                 155                 160 


Ala Thr Gly Thr Arg Val Ala Asp Ala Thr Lys Arg Ile Ser Glu Ile 
                165                 170                 175     


Ala Thr Arg Arg Ile Ala Thr Ile Ala Leu Asp Ile Ala Leu Lys Arg 
            180                 185                 190         


Leu Gln Thr Arg Gly Gln Ala Thr Leu Thr Val Thr His Lys Ser Asn 
        195                 200                 205             


Val Leu Ser Gln Ser Asp Gly Leu Phe Arg Glu Ile Cys Lys Glu Val 
    210                 215                 220                 


Tyr Glu Ser Asn Lys Asp Lys Tyr Gly Gln Ile Lys Tyr Asn Glu Gln 
225                 230                 235                 240 


Ile Val Asp Ser Met Val Tyr Arg Leu Phe Arg Glu Pro Gln Cys Phe 
                245                 250                 255     


Asp Val Ile Val Ala Pro Asn Leu Tyr Gly Asp Ile Leu Ser Asp Gly 
            260                 265                 270         


Ala Ala Ala Leu Val Gly Ser Leu Gly Val Val Pro Ser Ala Asn Val 
        275                 280                 285             


Gly Pro Glu Ile Val Ile Gly Glu Pro Cys His Gly Ser Ala Pro Asp 
    290                 295                 300                 


Ile Ala Gly Lys Gly Ile Ala Asn Pro Ile Ala Thr Ile Arg Ser Thr 
305                 310                 315                 320 


Ala Leu Met Leu Glu Phe Leu Gly His Asn Glu Ala Ala Gln Asp Ile 
                325                 330                 335     


Tyr Lys Ala Val Asp Ala Asn Leu Arg Glu Gly Ser Ile Lys Thr Pro 
            340                 345                 350         


Asp Leu Gly Gly Lys Ala Ser Thr Gln Gln Val Val Asp Asp Val Leu 
        355                 360                 365             


Ser Arg Leu 
    370     


<210>  7
<211>  1113
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ScHIDH R115Q polynucleotide

<400>  7
atgtttagat ctgttgctac tagattatct gcctgccgtg ggttagcatc taacgctgct       60

cgcaaatcac tcactattgg tcttatcccc ggtgacggta tcggtaagga agtcattcct      120

gctggtaagc aagttttgga aaaccttaac tccaagcacg gcctaagctt caactttatt      180

gatctctacg ccggtttcca aacattccaa gaaacaggaa aggcgttgcc tgatgagact      240

gttaaagtgt tgaaggaaca atgtcaaggt gctcttttcg gtgcagttca gtctccaact      300

actaaggtgg aaggttactc ctcaccaatt gttgctctaa ggcaggaaat gggccttttc      360

gctaatgttc gtcctgttaa gtctgtagag ggagaaaagg gtaaaccaat tgacatggtt      420

atcgtcagag aaaatactga ggacctgtac attaaaattg aaaaaacata cattgacaag      480

gccacaggta caagagttgc tgatgccaca aagagaatat ccgaaattgc aacaagaaga      540

attgcaacca ttgcattaga tattgccttg aaaagattac aaacaagagg ccaagccact      600

ttgacagtga ctcataaatc aaatgttcta tctcaaagtg atggtctatt cagagaaatc      660

tgtaaggaag tctacgaatc taacaaggac aagtacggtc aaatcaaata taacgaacaa      720

attgtggatt ccatggttta taggctgttc agagaaccac aatgttttga tgtgatagtg      780

gcaccaaacc tatacgggga tatattatct gacggtgctg ctgctttagt cggttcatta      840

ggtgttgttc caagcgccaa cgtaggtcca gaaattgtca ttggtgaacc atgccatggt      900

tctgcaccag atattgctgg taaaggtatt gctaacccaa tcgccactat aagatctact      960

gctttgatgt tggaattctt gggccacaac gaagctgccc aagatatcta caaggctgtt     1020

gatgctaact taagagaggg ttctatcaag acaccagatt taggtggtaa ggcttctact     1080

caacaagtcg ttgacgacgt tttgtcgaga tta                                  1113


<210>  8
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ScHIDH R115Q polypeptide

<400>  8

Met Phe Arg Ser Val Ala Thr Arg Leu Ser Ala Cys Arg Gly Leu Ala 
1               5                   10                  15      


Ser Asn Ala Ala Arg Lys Ser Leu Thr Ile Gly Leu Ile Pro Gly Asp 
            20                  25                  30          


Gly Ile Gly Lys Glu Val Ile Pro Ala Gly Lys Gln Val Leu Glu Asn 
        35                  40                  45              


Leu Asn Ser Lys His Gly Leu Ser Phe Asn Phe Ile Asp Leu Tyr Ala 
    50                  55                  60                  


Gly Phe Gln Thr Phe Gln Glu Thr Gly Lys Ala Leu Pro Asp Glu Thr 
65                  70                  75                  80  


Val Lys Val Leu Lys Glu Gln Cys Gln Gly Ala Leu Phe Gly Ala Val 
                85                  90                  95      


Gln Ser Pro Thr Thr Lys Val Glu Gly Tyr Ser Ser Pro Ile Val Ala 
            100                 105                 110         


Leu Arg Gln Glu Met Gly Leu Phe Ala Asn Val Arg Pro Val Lys Ser 
        115                 120                 125             


Val Glu Gly Glu Lys Gly Lys Pro Ile Asp Met Val Ile Val Arg Glu 
    130                 135                 140                 


Asn Thr Glu Asp Leu Tyr Ile Lys Ile Glu Lys Thr Tyr Ile Asp Lys 
145                 150                 155                 160 


Ala Thr Gly Thr Arg Val Ala Asp Ala Thr Lys Arg Ile Ser Glu Ile 
                165                 170                 175     


Ala Thr Arg Arg Ile Ala Thr Ile Ala Leu Asp Ile Ala Leu Lys Arg 
            180                 185                 190         


Leu Gln Thr Arg Gly Gln Ala Thr Leu Thr Val Thr His Lys Ser Asn 
        195                 200                 205             


Val Leu Ser Gln Ser Asp Gly Leu Phe Arg Glu Ile Cys Lys Glu Val 
    210                 215                 220                 


Tyr Glu Ser Asn Lys Asp Lys Tyr Gly Gln Ile Lys Tyr Asn Glu Gln 
225                 230                 235                 240 


Ile Val Asp Ser Met Val Tyr Arg Leu Phe Arg Glu Pro Gln Cys Phe 
                245                 250                 255     


Asp Val Ile Val Ala Pro Asn Leu Tyr Gly Asp Ile Leu Ser Asp Gly 
            260                 265                 270         


Ala Ala Ala Leu Val Gly Ser Leu Gly Val Val Pro Ser Ala Asn Val 
        275                 280                 285             


Gly Pro Glu Ile Val Ile Gly Glu Pro Cys His Gly Ser Ala Pro Asp 
    290                 295                 300                 


Ile Ala Gly Lys Gly Ile Ala Asn Pro Ile Ala Thr Ile Arg Ser Thr 
305                 310                 315                 320 


Ala Leu Met Leu Glu Phe Leu Gly His Asn Glu Ala Ala Gln Asp Ile 
                325                 330                 335     


Tyr Lys Ala Val Asp Ala Asn Leu Arg Glu Gly Ser Ile Lys Thr Pro 
            340                 345                 350         


Asp Leu Gly Gly Lys Ala Ser Thr Gln Gln Val Val Asp Asp Val Leu 
        355                 360                 365             


Ser Arg Leu 
    370     


<210>  9
<211>  1113
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ScHIDH R143C polynucleotide

<400>  9
atgtttagat ctgttgctac tagattatct gcctgccgtg ggttagcatc taacgctgct       60

cgcaaatcac tcactattgg tcttatcccc ggtgacggta tcggtaagga agtcattcct      120

gctggtaagc aagttttgga aaaccttaac tccaagcacg gcctaagctt caactttatt      180

gatctctacg ccggtttcca aacattccaa gaaacaggaa aggcgttgcc tgatgagact      240

gttaaagtgt tgaaggaaca atgtcaaggt gctcttttcg gtgcagttca gtctccaact      300

actaaggtgg aaggttactc ctcaccaatt gttgctctaa ggagggaaat gggccttttc      360

gctaatgttc gtcctgttaa gtctgtagag ggagaaaagg gtaaaccaat tgacatggtt      420

atcgtctgcg aaaatactga ggacctgtac attaaaattg aaaaaacata cattgacaag      480

gccacaggta caagagttgc tgatgccaca aagagaatat ccgaaattgc aacaagaaga      540

attgcaacca ttgcattaga tattgccttg aaaagattac aaacaagagg ccaagccact      600

ttgacagtga ctcataaatc aaatgttcta tctcaaagtg atggtctatt cagagaaatc      660

tgtaaggaag tctacgaatc taacaaggac aagtacggtc aaatcaaata taacgaacaa      720

attgtggatt ccatggttta taggctgttc agagaaccac aatgttttga tgtgatagtg      780

gcaccaaacc tatacgggga tatattatct gacggtgctg ctgctttagt cggttcatta      840

ggtgttgttc caagcgccaa cgtaggtcca gaaattgtca ttggtgaacc atgccatggt      900

tctgcaccag atattgctgg taaaggtatt gctaacccaa tcgccactat aagatctact      960

gctttgatgt tggaattctt gggccacaac gaagctgccc aagatatcta caaggctgtt     1020

gatgctaact taagagaggg ttctatcaag acaccagatt taggtggtaa ggcttctact     1080

caacaagtcg ttgacgacgt tttgtcgaga tta                                  1113


<210>  10
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ScHIDH R143C polypeptide

<400>  10

Met Phe Arg Ser Val Ala Thr Arg Leu Ser Ala Cys Arg Gly Leu Ala 
1               5                   10                  15      


Ser Asn Ala Ala Arg Lys Ser Leu Thr Ile Gly Leu Ile Pro Gly Asp 
            20                  25                  30          


Gly Ile Gly Lys Glu Val Ile Pro Ala Gly Lys Gln Val Leu Glu Asn 
        35                  40                  45              


Leu Asn Ser Lys His Gly Leu Ser Phe Asn Phe Ile Asp Leu Tyr Ala 
    50                  55                  60                  


Gly Phe Gln Thr Phe Gln Glu Thr Gly Lys Ala Leu Pro Asp Glu Thr 
65                  70                  75                  80  


Val Lys Val Leu Lys Glu Gln Cys Gln Gly Ala Leu Phe Gly Ala Val 
                85                  90                  95      


Gln Ser Pro Thr Thr Lys Val Glu Gly Tyr Ser Ser Pro Ile Val Ala 
            100                 105                 110         


Leu Arg Arg Glu Met Gly Leu Phe Ala Asn Val Arg Pro Val Lys Ser 
        115                 120                 125             


Val Glu Gly Glu Lys Gly Lys Pro Ile Asp Met Val Ile Val Cys Glu 
    130                 135                 140                 


Asn Thr Glu Asp Leu Tyr Ile Lys Ile Glu Lys Thr Tyr Ile Asp Lys 
145                 150                 155                 160 


Ala Thr Gly Thr Arg Val Ala Asp Ala Thr Lys Arg Ile Ser Glu Ile 
                165                 170                 175     


Ala Thr Arg Arg Ile Ala Thr Ile Ala Leu Asp Ile Ala Leu Lys Arg 
            180                 185                 190         


Leu Gln Thr Arg Gly Gln Ala Thr Leu Thr Val Thr His Lys Ser Asn 
        195                 200                 205             


Val Leu Ser Gln Ser Asp Gly Leu Phe Arg Glu Ile Cys Lys Glu Val 
    210                 215                 220                 


Tyr Glu Ser Asn Lys Asp Lys Tyr Gly Gln Ile Lys Tyr Asn Glu Gln 
225                 230                 235                 240 


Ile Val Asp Ser Met Val Tyr Arg Leu Phe Arg Glu Pro Gln Cys Phe 
                245                 250                 255     


Asp Val Ile Val Ala Pro Asn Leu Tyr Gly Asp Ile Leu Ser Asp Gly 
            260                 265                 270         


Ala Ala Ala Leu Val Gly Ser Leu Gly Val Val Pro Ser Ala Asn Val 
        275                 280                 285             


Gly Pro Glu Ile Val Ile Gly Glu Pro Cys His Gly Ser Ala Pro Asp 
    290                 295                 300                 


Ile Ala Gly Lys Gly Ile Ala Asn Pro Ile Ala Thr Ile Arg Ser Thr 
305                 310                 315                 320 


Ala Leu Met Leu Glu Phe Leu Gly His Asn Glu Ala Ala Gln Asp Ile 
                325                 330                 335     


Tyr Lys Ala Val Asp Ala Asn Leu Arg Glu Gly Ser Ile Lys Thr Pro 
            340                 345                 350         


Asp Leu Gly Gly Lys Ala Ser Thr Gln Gln Val Val Asp Asp Val Leu 
        355                 360                 365             


Ser Arg Leu 
    370     


<210>  11
<211>  1113
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ScHIDH R143H polynucleotide

<400>  11
atgtttagat ctgttgctac tagattatct gcctgccgtg ggttagcatc taacgctgct       60

cgcaaatcac tcactattgg tcttatcccc ggtgacggta tcggtaagga agtcattcct      120

gctggtaagc aagttttgga aaaccttaac tccaagcacg gcctaagctt caactttatt      180

gatctctacg ccggtttcca aacattccaa gaaacaggaa aggcgttgcc tgatgagact      240

gttaaagtgt tgaaggaaca atgtcaaggt gctcttttcg gtgcagttca gtctccaact      300

actaaggtgg aaggttactc ctcaccaatt gttgctctaa ggagggaaat gggccttttc      360

gctaatgttc gtcctgttaa gtctgtagag ggagaaaagg gtaaaccaat tgacatggtt      420

atcgtccatg aaaatactga ggacctgtac attaaaattg aaaaaacata cattgacaag      480

gccacaggta caagagttgc tgatgccaca aagagaatat ccgaaattgc aacaagaaga      540

attgcaacca ttgcattaga tattgccttg aaaagattac aaacaagagg ccaagccact      600

ttgacagtga ctcataaatc aaatgttcta tctcaaagtg atggtctatt cagagaaatc      660

tgtaaggaag tctacgaatc taacaaggac aagtacggtc aaatcaaata taacgaacaa      720

attgtggatt ccatggttta taggctgttc agagaaccac aatgttttga tgtgatagtg      780

gcaccaaacc tatacgggga tatattatct gacggtgctg ctgctttagt cggttcatta      840

ggtgttgttc caagcgccaa cgtaggtcca gaaattgtca ttggtgaacc atgccatggt      900

tctgcaccag atattgctgg taaaggtatt gctaacccaa tcgccactat aagatctact      960

gctttgatgt tggaattctt gggccacaac gaagctgccc aagatatcta caaggctgtt     1020

gatgctaact taagagaggg ttctatcaag acaccagatt taggtggtaa ggcttctact     1080

caacaagtcg ttgacgacgt tttgtcgaga tta                                  1113


<210>  12
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ScHIDH R143H polypeptide

<400>  12

Met Phe Arg Ser Val Ala Thr Arg Leu Ser Ala Cys Arg Gly Leu Ala 
1               5                   10                  15      


Ser Asn Ala Ala Arg Lys Ser Leu Thr Ile Gly Leu Ile Pro Gly Asp 
            20                  25                  30          


Gly Ile Gly Lys Glu Val Ile Pro Ala Gly Lys Gln Val Leu Glu Asn 
        35                  40                  45              


Leu Asn Ser Lys His Gly Leu Ser Phe Asn Phe Ile Asp Leu Tyr Ala 
    50                  55                  60                  


Gly Phe Gln Thr Phe Gln Glu Thr Gly Lys Ala Leu Pro Asp Glu Thr 
65                  70                  75                  80  


Val Lys Val Leu Lys Glu Gln Cys Gln Gly Ala Leu Phe Gly Ala Val 
                85                  90                  95      


Gln Ser Pro Thr Thr Lys Val Glu Gly Tyr Ser Ser Pro Ile Val Ala 
            100                 105                 110         


Leu Arg Arg Glu Met Gly Leu Phe Ala Asn Val Arg Pro Val Lys Ser 
        115                 120                 125             


Val Glu Gly Glu Lys Gly Lys Pro Ile Asp Met Val Ile Val His Glu 
    130                 135                 140                 


Asn Thr Glu Asp Leu Tyr Ile Lys Ile Glu Lys Thr Tyr Ile Asp Lys 
145                 150                 155                 160 


Ala Thr Gly Thr Arg Val Ala Asp Ala Thr Lys Arg Ile Ser Glu Ile 
                165                 170                 175     


Ala Thr Arg Arg Ile Ala Thr Ile Ala Leu Asp Ile Ala Leu Lys Arg 
            180                 185                 190         


Leu Gln Thr Arg Gly Gln Ala Thr Leu Thr Val Thr His Lys Ser Asn 
        195                 200                 205             


Val Leu Ser Gln Ser Asp Gly Leu Phe Arg Glu Ile Cys Lys Glu Val 
    210                 215                 220                 


Tyr Glu Ser Asn Lys Asp Lys Tyr Gly Gln Ile Lys Tyr Asn Glu Gln 
225                 230                 235                 240 


Ile Val Asp Ser Met Val Tyr Arg Leu Phe Arg Glu Pro Gln Cys Phe 
                245                 250                 255     


Asp Val Ile Val Ala Pro Asn Leu Tyr Gly Asp Ile Leu Ser Asp Gly 
            260                 265                 270         


Ala Ala Ala Leu Val Gly Ser Leu Gly Val Val Pro Ser Ala Asn Val 
        275                 280                 285             


Gly Pro Glu Ile Val Ile Gly Glu Pro Cys His Gly Ser Ala Pro Asp 
    290                 295                 300                 


Ile Ala Gly Lys Gly Ile Ala Asn Pro Ile Ala Thr Ile Arg Ser Thr 
305                 310                 315                 320 


Ala Leu Met Leu Glu Phe Leu Gly His Asn Glu Ala Ala Gln Asp Ile 
                325                 330                 335     


Tyr Lys Ala Val Asp Ala Asn Leu Arg Glu Gly Ser Ile Lys Thr Pro 
            340                 345                 350         


Asp Leu Gly Gly Lys Ala Ser Thr Gln Gln Val Val Asp Asp Val Leu 
        355                 360                 365             


Ser Arg Leu 
    370     


<210>  13
<211>  1113
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ScHIDH R143K polynucleotide

<400>  13
atgtttagat ctgttgctac tagattatct gcctgccgtg ggttagcatc taacgctgct       60

cgcaaatcac tcactattgg tcttatcccc ggtgacggta tcggtaagga agtcattcct      120

gctggtaagc aagttttgga aaaccttaac tccaagcacg gcctaagctt caactttatt      180

gatctctacg ccggtttcca aacattccaa gaaacaggaa aggcgttgcc tgatgagact      240

gttaaagtgt tgaaggaaca atgtcaaggt gctcttttcg gtgcagttca gtctccaact      300

actaaggtgg aaggttactc ctcaccaatt gttgctctaa ggagggaaat gggccttttc      360

gctaatgttc gtcctgttaa gtctgtagag ggagaaaagg gtaaaccaat tgacatggtt      420

atcgtcaaag aaaatactga ggacctgtac attaaaattg aaaaaacata cattgacaag      480

gccacaggta caagagttgc tgatgccaca aagagaatat ccgaaattgc aacaagaaga      540

attgcaacca ttgcattaga tattgccttg aaaagattac aaacaagagg ccaagccact      600

ttgacagtga ctcataaatc aaatgttcta tctcaaagtg atggtctatt cagagaaatc      660

tgtaaggaag tctacgaatc taacaaggac aagtacggtc aaatcaaata taacgaacaa      720

attgtggatt ccatggttta taggctgttc agagaaccac aatgttttga tgtgatagtg      780

gcaccaaacc tatacgggga tatattatct gacggtgctg ctgctttagt cggttcatta      840

ggtgttgttc caagcgccaa cgtaggtcca gaaattgtca ttggtgaacc atgccatggt      900

tctgcaccag atattgctgg taaaggtatt gctaacccaa tcgccactat aagatctact      960

gctttgatgt tggaattctt gggccacaac gaagctgccc aagatatcta caaggctgtt     1020

gatgctaact taagagaggg ttctatcaag acaccagatt taggtggtaa ggcttctact     1080

caacaagtcg ttgacgacgt tttgtcgaga tta                                  1113


<210>  14
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ScHIDH R143K polypeptide

<400>  14

Met Phe Arg Ser Val Ala Thr Arg Leu Ser Ala Cys Arg Gly Leu Ala 
1               5                   10                  15      


Ser Asn Ala Ala Arg Lys Ser Leu Thr Ile Gly Leu Ile Pro Gly Asp 
            20                  25                  30          


Gly Ile Gly Lys Glu Val Ile Pro Ala Gly Lys Gln Val Leu Glu Asn 
        35                  40                  45              


Leu Asn Ser Lys His Gly Leu Ser Phe Asn Phe Ile Asp Leu Tyr Ala 
    50                  55                  60                  


Gly Phe Gln Thr Phe Gln Glu Thr Gly Lys Ala Leu Pro Asp Glu Thr 
65                  70                  75                  80  


Val Lys Val Leu Lys Glu Gln Cys Gln Gly Ala Leu Phe Gly Ala Val 
                85                  90                  95      


Gln Ser Pro Thr Thr Lys Val Glu Gly Tyr Ser Ser Pro Ile Val Ala 
            100                 105                 110         


Leu Arg Arg Glu Met Gly Leu Phe Ala Asn Val Arg Pro Val Lys Ser 
        115                 120                 125             


Val Glu Gly Glu Lys Gly Lys Pro Ile Asp Met Val Ile Val Lys Glu 
    130                 135                 140                 


Asn Thr Glu Asp Leu Tyr Ile Lys Ile Glu Lys Thr Tyr Ile Asp Lys 
145                 150                 155                 160 


Ala Thr Gly Thr Arg Val Ala Asp Ala Thr Lys Arg Ile Ser Glu Ile 
                165                 170                 175     


Ala Thr Arg Arg Ile Ala Thr Ile Ala Leu Asp Ile Ala Leu Lys Arg 
            180                 185                 190         


Leu Gln Thr Arg Gly Gln Ala Thr Leu Thr Val Thr His Lys Ser Asn 
        195                 200                 205             


Val Leu Ser Gln Ser Asp Gly Leu Phe Arg Glu Ile Cys Lys Glu Val 
    210                 215                 220                 


Tyr Glu Ser Asn Lys Asp Lys Tyr Gly Gln Ile Lys Tyr Asn Glu Gln 
225                 230                 235                 240 


Ile Val Asp Ser Met Val Tyr Arg Leu Phe Arg Glu Pro Gln Cys Phe 
                245                 250                 255     


Asp Val Ile Val Ala Pro Asn Leu Tyr Gly Asp Ile Leu Ser Asp Gly 
            260                 265                 270         


Ala Ala Ala Leu Val Gly Ser Leu Gly Val Val Pro Ser Ala Asn Val 
        275                 280                 285             


Gly Pro Glu Ile Val Ile Gly Glu Pro Cys His Gly Ser Ala Pro Asp 
    290                 295                 300                 


Ile Ala Gly Lys Gly Ile Ala Asn Pro Ile Ala Thr Ile Arg Ser Thr 
305                 310                 315                 320 


Ala Leu Met Leu Glu Phe Leu Gly His Asn Glu Ala Ala Gln Asp Ile 
                325                 330                 335     


Tyr Lys Ala Val Asp Ala Asn Leu Arg Glu Gly Ser Ile Lys Thr Pro 
            340                 345                 350         


Asp Leu Gly Gly Lys Ala Ser Thr Gln Gln Val Val Asp Asp Val Leu 
        355                 360                 365             


Ser Arg Leu 
    370     


<210>  15
<211>  1113
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ScHIDH Y150D polynucleotide

<400>  15
atgtttagat ctgttgctac tagattatct gcctgccgtg ggttagcatc taacgctgct       60

cgcaaatcac tcactattgg tcttatcccc ggtgacggta tcggtaagga agtcattcct      120

gctggtaagc aagttttgga aaaccttaac tccaagcacg gcctaagctt caactttatt      180

gatctctacg ccggtttcca aacattccaa gaaacaggaa aggcgttgcc tgatgagact      240

gttaaagtgt tgaaggaaca atgtcaaggt gctcttttcg gtgcagttca gtctccaact      300

actaaggtgg aaggttactc ctcaccaatt gttgctctaa ggagggaaat gggccttttc      360

gctaatgttc gtcctgttaa gtctgtagag ggagaaaagg gtaaaccaat tgacatggtt      420

atcgtcagag aaaatactga ggacctggac attaaaattg aaaaaacata cattgacaag      480

gccacaggta caagagttgc tgatgccaca aagagaatat ccgaaattgc aacaagaaga      540

attgcaacca ttgcattaga tattgccttg aaaagattac aaacaagagg ccaagccact      600

ttgacagtga ctcataaatc aaatgttcta tctcaaagtg atggtctatt cagagaaatc      660

tgtaaggaag tctacgaatc taacaaggac aagtacggtc aaatcaaata taacgaacaa      720

attgtggatt ccatggttta taggctgttc agagaaccac aatgttttga tgtgatagtg      780

gcaccaaacc tatacgggga tatattatct gacggtgctg ctgctttagt cggttcatta      840

ggtgttgttc caagcgccaa cgtaggtcca gaaattgtca ttggtgaacc atgccatggt      900

tctgcaccag atattgctgg taaaggtatt gctaacccaa tcgccactat aagatctact      960

gctttgatgt tggaattctt gggccacaac gaagctgccc aagatatcta caaggctgtt     1020

gatgctaact taagagaggg ttctatcaag acaccagatt taggtggtaa ggcttctact     1080

caacaagtcg ttgacgacgt tttgtcgaga tta                                  1113


<210>  16
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ScHIDH Y150D polypeptide

<400>  16

Met Phe Arg Ser Val Ala Thr Arg Leu Ser Ala Cys Arg Gly Leu Ala 
1               5                   10                  15      


Ser Asn Ala Ala Arg Lys Ser Leu Thr Ile Gly Leu Ile Pro Gly Asp 
            20                  25                  30          


Gly Ile Gly Lys Glu Val Ile Pro Ala Gly Lys Gln Val Leu Glu Asn 
        35                  40                  45              


Leu Asn Ser Lys His Gly Leu Ser Phe Asn Phe Ile Asp Leu Tyr Ala 
    50                  55                  60                  


Gly Phe Gln Thr Phe Gln Glu Thr Gly Lys Ala Leu Pro Asp Glu Thr 
65                  70                  75                  80  


Val Lys Val Leu Lys Glu Gln Cys Gln Gly Ala Leu Phe Gly Ala Val 
                85                  90                  95      


Gln Ser Pro Thr Thr Lys Val Glu Gly Tyr Ser Ser Pro Ile Val Ala 
            100                 105                 110         


Leu Arg Arg Glu Met Gly Leu Phe Ala Asn Val Arg Pro Val Lys Ser 
        115                 120                 125             


Val Glu Gly Glu Lys Gly Lys Pro Ile Asp Met Val Ile Val Arg Glu 
    130                 135                 140                 


Asn Thr Glu Asp Leu Asp Ile Lys Ile Glu Lys Thr Tyr Ile Asp Lys 
145                 150                 155                 160 


Ala Thr Gly Thr Arg Val Ala Asp Ala Thr Lys Arg Ile Ser Glu Ile 
                165                 170                 175     


Ala Thr Arg Arg Ile Ala Thr Ile Ala Leu Asp Ile Ala Leu Lys Arg 
            180                 185                 190         


Leu Gln Thr Arg Gly Gln Ala Thr Leu Thr Val Thr His Lys Ser Asn 
        195                 200                 205             


Val Leu Ser Gln Ser Asp Gly Leu Phe Arg Glu Ile Cys Lys Glu Val 
    210                 215                 220                 


Tyr Glu Ser Asn Lys Asp Lys Tyr Gly Gln Ile Lys Tyr Asn Glu Gln 
225                 230                 235                 240 


Ile Val Asp Ser Met Val Tyr Arg Leu Phe Arg Glu Pro Gln Cys Phe 
                245                 250                 255     


Asp Val Ile Val Ala Pro Asn Leu Tyr Gly Asp Ile Leu Ser Asp Gly 
            260                 265                 270         


Ala Ala Ala Leu Val Gly Ser Leu Gly Val Val Pro Ser Ala Asn Val 
        275                 280                 285             


Gly Pro Glu Ile Val Ile Gly Glu Pro Cys His Gly Ser Ala Pro Asp 
    290                 295                 300                 


Ile Ala Gly Lys Gly Ile Ala Asn Pro Ile Ala Thr Ile Arg Ser Thr 
305                 310                 315                 320 


Ala Leu Met Leu Glu Phe Leu Gly His Asn Glu Ala Ala Gln Asp Ile 
                325                 330                 335     


Tyr Lys Ala Val Asp Ala Asn Leu Arg Glu Gly Ser Ile Lys Thr Pro 
            340                 345                 350         


Asp Leu Gly Gly Lys Ala Ser Thr Gln Gln Val Val Asp Asp Val Leu 
        355                 360                 365             


Ser Arg Leu 
    370     


<210>  17
<211>  1113
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ScHIDH R114Q R143C polynucleotide

<400>  17
atgtttagat ctgttgctac tagattatct gcctgccgtg ggttagcatc taacgctgct       60

cgcaaatcac tcactattgg tcttatcccc ggtgacggta tcggtaagga agtcattcct      120

gctggtaagc aagttttgga aaaccttaac tccaagcacg gcctaagctt caactttatt      180

gatctctacg ccggtttcca aacattccaa gaaacaggaa aggcgttgcc tgatgagact      240

gttaaagtgt tgaaggaaca atgtcaaggt gctcttttcg gtgcagttca gtctccaact      300

actaaggtgg aaggttactc ctcaccaatt gttgctctac agagggaaat gggccttttc      360

gctaatgttc gtcctgttaa gtctgtagag ggagaaaagg gtaaaccaat tgacatggtt      420

atcgtctgcg aaaatactga ggacctgtac attaaaattg aaaaaacata cattgacaag      480

gccacaggta caagagttgc tgatgccaca aagagaatat ccgaaattgc aacaagaaga      540

attgcaacca ttgcattaga tattgccttg aaaagattac aaacaagagg ccaagccact      600

ttgacagtga ctcataaatc aaatgttcta tctcaaagtg atggtctatt cagagaaatc      660

tgtaaggaag tctacgaatc taacaaggac aagtacggtc aaatcaaata taacgaacaa      720

attgtggatt ccatggttta taggctgttc agagaaccac aatgttttga tgtgatagtg      780

gcaccaaacc tatacgggga tatattatct gacggtgctg ctgctttagt cggttcatta      840

ggtgttgttc caagcgccaa cgtaggtcca gaaattgtca ttggtgaacc atgccatggt      900

tctgcaccag atattgctgg taaaggtatt gctaacccaa tcgccactat aagatctact      960

gctttgatgt tggaattctt gggccacaac gaagctgccc aagatatcta caaggctgtt     1020

gatgctaact taagagaggg ttctatcaag acaccagatt taggtggtaa ggcttctact     1080

caacaagtcg ttgacgacgt tttgtcgaga tta                                  1113


<210>  18
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ScHIDH R114Q R143C polypeptide

<400>  18

Met Phe Arg Ser Val Ala Thr Arg Leu Ser Ala Cys Arg Gly Leu Ala 
1               5                   10                  15      


Ser Asn Ala Ala Arg Lys Ser Leu Thr Ile Gly Leu Ile Pro Gly Asp 
            20                  25                  30          


Gly Ile Gly Lys Glu Val Ile Pro Ala Gly Lys Gln Val Leu Glu Asn 
        35                  40                  45              


Leu Asn Ser Lys His Gly Leu Ser Phe Asn Phe Ile Asp Leu Tyr Ala 
    50                  55                  60                  


Gly Phe Gln Thr Phe Gln Glu Thr Gly Lys Ala Leu Pro Asp Glu Thr 
65                  70                  75                  80  


Val Lys Val Leu Lys Glu Gln Cys Gln Gly Ala Leu Phe Gly Ala Val 
                85                  90                  95      


Gln Ser Pro Thr Thr Lys Val Glu Gly Tyr Ser Ser Pro Ile Val Ala 
            100                 105                 110         


Leu Gln Arg Glu Met Gly Leu Phe Ala Asn Val Arg Pro Val Lys Ser 
        115                 120                 125             


Val Glu Gly Glu Lys Gly Lys Pro Ile Asp Met Val Ile Val Cys Glu 
    130                 135                 140                 


Asn Thr Glu Asp Leu Tyr Ile Lys Ile Glu Lys Thr Tyr Ile Asp Lys 
145                 150                 155                 160 


Ala Thr Gly Thr Arg Val Ala Asp Ala Thr Lys Arg Ile Ser Glu Ile 
                165                 170                 175     


Ala Thr Arg Arg Ile Ala Thr Ile Ala Leu Asp Ile Ala Leu Lys Arg 
            180                 185                 190         


Leu Gln Thr Arg Gly Gln Ala Thr Leu Thr Val Thr His Lys Ser Asn 
        195                 200                 205             


Val Leu Ser Gln Ser Asp Gly Leu Phe Arg Glu Ile Cys Lys Glu Val 
    210                 215                 220                 


Tyr Glu Ser Asn Lys Asp Lys Tyr Gly Gln Ile Lys Tyr Asn Glu Gln 
225                 230                 235                 240 


Ile Val Asp Ser Met Val Tyr Arg Leu Phe Arg Glu Pro Gln Cys Phe 
                245                 250                 255     


Asp Val Ile Val Ala Pro Asn Leu Tyr Gly Asp Ile Leu Ser Asp Gly 
            260                 265                 270         


Ala Ala Ala Leu Val Gly Ser Leu Gly Val Val Pro Ser Ala Asn Val 
        275                 280                 285             


Gly Pro Glu Ile Val Ile Gly Glu Pro Cys His Gly Ser Ala Pro Asp 
    290                 295                 300                 


Ile Ala Gly Lys Gly Ile Ala Asn Pro Ile Ala Thr Ile Arg Ser Thr 
305                 310                 315                 320 


Ala Leu Met Leu Glu Phe Leu Gly His Asn Glu Ala Ala Gln Asp Ile 
                325                 330                 335     


Tyr Lys Ala Val Asp Ala Asn Leu Arg Glu Gly Ser Ile Lys Thr Pro 
            340                 345                 350         


Asp Leu Gly Gly Lys Ala Ser Thr Gln Gln Val Val Asp Asp Val Leu 
        355                 360                 365             


Ser Arg Leu 
    370     


<210>  19
<211>  1005
<212>  DNA
<213>  Thermus thermophilus

<400>  19
atggcgtacc ggatctgctt gattgagggc gacggcatcg ggcacgaggt catccccgcg       60

gcgcggaggg tgctggaggc caccggcctc cccctggagt tcgtggaggc ggaggcgggc      120

tgggagacct ttgagagaag agggacctcc gtccccgagg agacggtgga gaagatcctg      180

tcctgccacg ccaccctctt cggggccgcc accagcccca cccgtaaagt gccgggcttc      240

ttcggggcga tccgctacct caggcgcagg ctggacctct acgccaacgt ccgccccgcc      300

aagagccgcc ccgtcccggg aagccgcccc ggcgtggacc tggtcatcgt ccgggagaac      360

accgaagggc tttacgtgga gcaggaaagg cgctacctgg acgtggccat cgccgacgcc      420

gtcatctcca agaaggccag cgagcgcatc ggccgggccg ccttaaggat cgccgagggc      480

cggccccgca aaacccttca catcgcccac aaggccaacg tcctccccct cacccagggg      540

ctcttcctgg acacggtcaa ggaggtggcc aaggacttcc ccctggtgaa cgtgcaggac      600

atcatcgtgg acaactgcgc catgcagctc gtcatgcgtc ccgagcgctt tgacgtcatc      660

gtcaccacca acctcctggg ggacatcctc tccgacctcg ccgcggggct cgtggggggc      720

ctgggcctcg ccccctcggg caacatcggg gacaccaccg cggtctttga gcccgtccac      780

ggctccgccc ccgacatcgc cggcaagggc atcgccaacc ccacggcggc catcctctcc      840

gcggccatga tgctggacta cctgggggag aaggaggcgg ccaagcgggt ggagaaggcg      900

gtggacctgg tgctggagcg ggggcccagg acccctgacc tgggcgggga cgccaccacg      960

gaagccttca ccgaggccgt ggtggaggcg ctcaagagcc tgtag                     1005


<210>  20
<211>  334
<212>  PRT
<213>  Thermus thermophilus

<400>  20

Met Ala Tyr Arg Ile Cys Leu Ile Glu Gly Asp Gly Ile Gly His Glu 
1               5                   10                  15      


Val Ile Pro Ala Ala Arg Arg Val Leu Glu Ala Thr Gly Leu Pro Leu 
            20                  25                  30          


Glu Phe Val Glu Ala Glu Ala Gly Trp Glu Thr Phe Glu Arg Arg Gly 
        35                  40                  45              


Thr Ser Val Pro Glu Glu Thr Val Glu Lys Ile Leu Ser Cys His Ala 
    50                  55                  60                  


Thr Leu Phe Gly Ala Ala Thr Ser Pro Thr Arg Lys Val Pro Gly Phe 
65                  70                  75                  80  


Phe Gly Ala Ile Arg Tyr Leu Arg Arg Arg Leu Asp Leu Tyr Ala Asn 
                85                  90                  95      


Val Arg Pro Ala Lys Ser Arg Pro Val Pro Gly Ser Arg Pro Gly Val 
            100                 105                 110         


Asp Leu Val Ile Val Arg Glu Asn Thr Glu Gly Leu Tyr Val Glu Gln 
        115                 120                 125             


Glu Arg Arg Tyr Leu Asp Val Ala Ile Ala Asp Ala Val Ile Ser Lys 
    130                 135                 140                 


Lys Ala Ser Glu Arg Ile Gly Arg Ala Ala Leu Arg Ile Ala Glu Gly 
145                 150                 155                 160 


Arg Pro Arg Lys Thr Leu His Ile Ala His Lys Ala Asn Val Leu Pro 
                165                 170                 175     


Leu Thr Gln Gly Leu Phe Leu Asp Thr Val Lys Glu Val Ala Lys Asp 
            180                 185                 190         


Phe Pro Leu Val Asn Val Gln Asp Ile Ile Val Asp Asn Cys Ala Met 
        195                 200                 205             


Gln Leu Val Met Arg Pro Glu Arg Phe Asp Val Ile Val Thr Thr Asn 
    210                 215                 220                 


Leu Leu Gly Asp Ile Leu Ser Asp Leu Ala Ala Gly Leu Val Gly Gly 
225                 230                 235                 240 


Leu Gly Leu Ala Pro Ser Gly Asn Ile Gly Asp Thr Thr Ala Val Phe 
                245                 250                 255     


Glu Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly Lys Gly Ile Ala 
            260                 265                 270         


Asn Pro Thr Ala Ala Ile Leu Ser Ala Ala Met Met Leu Asp Tyr Leu 
        275                 280                 285             


Gly Glu Lys Glu Ala Ala Lys Arg Val Glu Lys Ala Val Asp Leu Val 
    290                 295                 300                 


Leu Glu Arg Gly Pro Arg Thr Pro Asp Leu Gly Gly Asp Ala Thr Thr 
305                 310                 315                 320 


Glu Ala Phe Thr Glu Ala Val Val Glu Ala Leu Lys Ser Leu 
                325                 330                 


<210>  21
<211>  1002
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TtHIDH R118H polynucleotide

<400>  21
atggcgtacc ggatctgctt gattgagggc gacggcatcg ggcacgaggt catccccgcg       60

gcgcggaggg tgctggaggc caccggcctc cccctggagt tcgtggaggc ggaggcgggc      120

tgggagacct ttgagagaag agggacctcc gtccccgagg agacggtgga gaagatcctg      180

tcctgccacg ccaccctctt cggggccgcc accagcccca cccgtaaagt gccgggcttc      240

ttcggggcga tccgctacct caggcgcagg ctggacctct acgccaacgt ccgccccgcc      300

aagagccgcc ccgtcccggg aagccgcccc ggcgtggacc tggtcatcgt ccatgagaac      360

accgaagggc tttacgtgga gcaggaaagg cgctacctgg acgtggccat cgccgacgcc      420

gtcatctcca agaaggccag cgagcgcatc ggccgggccg ccttaaggat cgccgagggc      480

cggccccgca aaacccttca catcgcccac aaggccaacg tcctccccct cacccagggg      540

ctcttcctgg acacggtcaa ggaggtggcc aaggacttcc ccctggtgaa cgtgcaggac      600

atcatcgtgg acaactgcgc catgcagctc gtcatgcgtc ccgagcgctt tgacgtcatc      660

gtcaccacca acctcctggg ggacatcctc tccgacctcg ccgcggggct cgtggggggc      720

ctgggcctcg ccccctcggg caacatcggg gacaccaccg cggtctttga gcccgtccac      780

ggctccgccc ccgacatcgc cggcaagggc atcgccaacc ccacggcggc catcctctcc      840

gcggccatga tgctggacta cctgggggag aaggaggcgg ccaagcgggt ggagaaggcg      900

gtggacctgg tgctggagcg ggggcccagg acccctgacc tgggcgggga cgccaccacg      960

gaagccttca ccgaggccgt ggtggaggcg ctcaagagcc tg                        1002


<210>  22
<211>  334
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TtHIDH R118H polypeptide

<400>  22

Met Ala Tyr Arg Ile Cys Leu Ile Glu Gly Asp Gly Ile Gly His Glu 
1               5                   10                  15      


Val Ile Pro Ala Ala Arg Arg Val Leu Glu Ala Thr Gly Leu Pro Leu 
            20                  25                  30          


Glu Phe Val Glu Ala Glu Ala Gly Trp Glu Thr Phe Glu Arg Arg Gly 
        35                  40                  45              


Thr Ser Val Pro Glu Glu Thr Val Glu Lys Ile Leu Ser Cys His Ala 
    50                  55                  60                  


Thr Leu Phe Gly Ala Ala Thr Ser Pro Thr Arg Lys Val Pro Gly Phe 
65                  70                  75                  80  


Phe Gly Ala Ile Arg Tyr Leu Arg Arg Arg Leu Asp Leu Tyr Ala Asn 
                85                  90                  95      


Val Arg Pro Ala Lys Ser Arg Pro Val Pro Gly Ser Arg Pro Gly Val 
            100                 105                 110         


Asp Leu Val Ile Val His Glu Asn Thr Glu Gly Leu Tyr Val Glu Gln 
        115                 120                 125             


Glu Arg Arg Tyr Leu Asp Val Ala Ile Ala Asp Ala Val Ile Ser Lys 
    130                 135                 140                 


Lys Ala Ser Glu Arg Ile Gly Arg Ala Ala Leu Arg Ile Ala Glu Gly 
145                 150                 155                 160 


Arg Pro Arg Lys Thr Leu His Ile Ala His Lys Ala Asn Val Leu Pro 
                165                 170                 175     


Leu Thr Gln Gly Leu Phe Leu Asp Thr Val Lys Glu Val Ala Lys Asp 
            180                 185                 190         


Phe Pro Leu Val Asn Val Gln Asp Ile Ile Val Asp Asn Cys Ala Met 
        195                 200                 205             


Gln Leu Val Met Arg Pro Glu Arg Phe Asp Val Ile Val Thr Thr Asn 
    210                 215                 220                 


Leu Leu Gly Asp Ile Leu Ser Asp Leu Ala Ala Gly Leu Val Gly Gly 
225                 230                 235                 240 


Leu Gly Leu Ala Pro Ser Gly Asn Ile Gly Asp Thr Thr Ala Val Phe 
                245                 250                 255     


Glu Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly Lys Gly Ile Ala 
            260                 265                 270         


Asn Pro Thr Ala Ala Ile Leu Ser Ala Ala Met Met Leu Asp Tyr Leu 
        275                 280                 285             


Gly Glu Lys Glu Ala Ala Lys Arg Val Glu Lys Ala Val Asp Leu Val 
    290                 295                 300                 


Leu Glu Arg Gly Pro Arg Thr Pro Asp Leu Gly Gly Asp Ala Thr Thr 
305                 310                 315                 320 


Glu Ala Phe Thr Glu Ala Val Val Glu Ala Leu Lys Ser Leu 
                325                 330                 


<210>  23
<211>  1095
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  23
atgtctgccc ctaagaagat cgtcgttttg ccaggtgacc acgttggtca agaaatcaca       60

gccgaagcca ttaaggttct taaagctatt tctgatgttc gttccaatgt caagttcgat      120

ttcgaaaatc atttaattgg tggtgctgct atcgatgcta caggtgttcc acttccagat      180

gaggcgctgg aagcctccaa gaaggctgat gccgttttgt taggtgctgt gggtggtcct      240

aaatggggta ccggtagtgt tagacctgaa caaggtttac taaaaatccg taaagaactt      300

caattgtacg ccaacttaag accatgtaac tttgcatccg actctctttt agacttatct      360

ccaatcaagc cacaatttgc taaaggtact gacttcgttg ttgtcagaga attagtggga      420

ggtatttact ttggtaagag aaaggaagac gatggtgatg gtgtcgcttg ggatagtgaa      480

caatacaccg ttccagaagt gcaaagaatc acaagaatgg ccgctttcat ggccctacaa      540

catgagccac cattgcctat ttggtccttg gataaagcta atgttttggc ctcttcaaga      600

ttatggagaa aaactgtgga ggaaaccatc aagaacgaat tccctacatt gaaggttcaa      660

catcaattga ttgattctgc cgccatgatc ctagttaaga acccaaccca cctaaatggt      720

attataatca ccagcaacat gtttggtgat atcatctccg atgaagcctc cgttatccca      780

ggttccttgg gtttgttgcc atctgcgtcc ttggcctctt tgccagacaa gaacaccgca      840

tttggtttgt acgaaccatg ccacggttct gctccagatt tgccaaagaa taaggtcaac      900

cctatcgcca ctatcttgtc tgctgcaatg atgttgaaat tgtcattgaa cttgcctgaa      960

gaaggtaagg ccattgaaga tgcagttaaa aaggttttgg atgcaggtat cagaactggt     1020

gatttaggtg gttccaacag taccaccgaa gtcggtgatg ctgtcgccga agaagttaag     1080

aaaatccttg cttaa                                                      1095


<210>  24
<211>  364
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  24

Met Ser Ala Pro Lys Lys Ile Val Val Leu Pro Gly Asp His Val Gly 
1               5                   10                  15      


Gln Glu Ile Thr Ala Glu Ala Ile Lys Val Leu Lys Ala Ile Ser Asp 
            20                  25                  30          


Val Arg Ser Asn Val Lys Phe Asp Phe Glu Asn His Leu Ile Gly Gly 
        35                  40                  45              


Ala Ala Ile Asp Ala Thr Gly Val Pro Leu Pro Asp Glu Ala Leu Glu 
    50                  55                  60                  


Ala Ser Lys Lys Ala Asp Ala Val Leu Leu Gly Ala Val Gly Gly Pro 
65                  70                  75                  80  


Lys Trp Gly Thr Gly Ser Val Arg Pro Glu Gln Gly Leu Leu Lys Ile 
                85                  90                  95      


Arg Lys Glu Leu Gln Leu Tyr Ala Asn Leu Arg Pro Cys Asn Phe Ala 
            100                 105                 110         


Ser Asp Ser Leu Leu Asp Leu Ser Pro Ile Lys Pro Gln Phe Ala Lys 
        115                 120                 125             


Gly Thr Asp Phe Val Val Val Arg Glu Leu Val Gly Gly Ile Tyr Phe 
    130                 135                 140                 


Gly Lys Arg Lys Glu Asp Asp Gly Asp Gly Val Ala Trp Asp Ser Glu 
145                 150                 155                 160 


Gln Tyr Thr Val Pro Glu Val Gln Arg Ile Thr Arg Met Ala Ala Phe 
                165                 170                 175     


Met Ala Leu Gln His Glu Pro Pro Leu Pro Ile Trp Ser Leu Asp Lys 
            180                 185                 190         


Ala Asn Val Leu Ala Ser Ser Arg Leu Trp Arg Lys Thr Val Glu Glu 
        195                 200                 205             


Thr Ile Lys Asn Glu Phe Pro Thr Leu Lys Val Gln His Gln Leu Ile 
    210                 215                 220                 


Asp Ser Ala Ala Met Ile Leu Val Lys Asn Pro Thr His Leu Asn Gly 
225                 230                 235                 240 


Ile Ile Ile Thr Ser Asn Met Phe Gly Asp Ile Ile Ser Asp Glu Ala 
                245                 250                 255     


Ser Val Ile Pro Gly Ser Leu Gly Leu Leu Pro Ser Ala Ser Leu Ala 
            260                 265                 270         


Ser Leu Pro Asp Lys Asn Thr Ala Phe Gly Leu Tyr Glu Pro Cys His 
        275                 280                 285             


Gly Ser Ala Pro Asp Leu Pro Lys Asn Lys Val Asn Pro Ile Ala Thr 
    290                 295                 300                 


Ile Leu Ser Ala Ala Met Met Leu Lys Leu Ser Leu Asn Leu Pro Glu 
305                 310                 315                 320 


Glu Gly Lys Ala Ile Glu Asp Ala Val Lys Lys Val Leu Asp Ala Gly 
                325                 330                 335     


Ile Arg Thr Gly Asp Leu Gly Gly Ser Asn Ser Thr Thr Glu Val Gly 
            340                 345                 350         


Asp Ala Val Ala Glu Glu Val Lys Lys Ile Leu Ala 
        355                 360                 


<210>  25
<211>  1095
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ScIPMDH R136H polynucleotide

<400>  25
atgtctgccc ctaagaagat cgtcgttttg ccaggtgacc acgttggtca agaaatcaca       60

gccgaagcca ttaaggttct taaagctatt tctgatgttc gttccaatgt caagttcgat      120

ttcgaaaatc atttaattgg tggtgctgct atcgatgcta caggtgttcc acttccagat      180

gaggcgctgg aagcctccaa gaaggctgat gccgttttgt taggtgctgt gggtggtcct      240

aaatggggta ccggtagtgt tagacctgaa caaggtttac taaaaatccg taaagaactt      300

caattgtacg ccaacttaag accatgtaac tttgcatccg actctctttt agacttatct      360

ccaatcaagc cacaatttgc taaaggtact gacttcgttg ttgtccatga attagtggga      420

ggtatttact ttggtaagag aaaggaagac gatggtgatg gtgtcgcttg ggatagtgaa      480

caatacaccg ttccagaagt gcaaagaatc acaagaatgg ccgctttcat ggccctacaa      540

catgagccac cattgcctat ttggtccttg gataaagcta atgttttggc ctcttcaaga      600

ttatggagaa aaactgtgga ggaaaccatc aagaacgaat tccctacatt gaaggttcaa      660

catcaattga ttgattctgc cgccatgatc ctagttaaga acccaaccca cctaaatggt      720

attataatca ccagcaacat gtttggtgat atcatctccg atgaagcctc cgttatccca      780

ggttccttgg gtttgttgcc atctgcgtcc ttggcctctt tgccagacaa gaacaccgca      840

tttggtttgt acgaaccatg ccacggttct gctccagatt tgccaaagaa taaggtcaac      900

cctatcgcca ctatcttgtc tgctgcaatg atgttgaaat tgtcattgaa cttgcctgaa      960

gaaggtaagg ccattgaaga tgcagttaaa aaggttttgg atgcaggtat cagaactggt     1020

gatttaggtg gttccaacag taccaccgaa gtcggtgatg ctgtcgccga agaagttaag     1080

aaaatccttg cttaa                                                      1095


<210>  26
<211>  364
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ScIPMDH R136H polypeptide

<400>  26

Met Ser Ala Pro Lys Lys Ile Val Val Leu Pro Gly Asp His Val Gly 
1               5                   10                  15      


Gln Glu Ile Thr Ala Glu Ala Ile Lys Val Leu Lys Ala Ile Ser Asp 
            20                  25                  30          


Val Arg Ser Asn Val Lys Phe Asp Phe Glu Asn His Leu Ile Gly Gly 
        35                  40                  45              


Ala Ala Ile Asp Ala Thr Gly Val Pro Leu Pro Asp Glu Ala Leu Glu 
    50                  55                  60                  


Ala Ser Lys Lys Ala Asp Ala Val Leu Leu Gly Ala Val Gly Gly Pro 
65                  70                  75                  80  


Lys Trp Gly Thr Gly Ser Val Arg Pro Glu Gln Gly Leu Leu Lys Ile 
                85                  90                  95      


Arg Lys Glu Leu Gln Leu Tyr Ala Asn Leu Arg Pro Cys Asn Phe Ala 
            100                 105                 110         


Ser Asp Ser Leu Leu Asp Leu Ser Pro Ile Lys Pro Gln Phe Ala Lys 
        115                 120                 125             


Gly Thr Asp Phe Val Val Val His Glu Leu Val Gly Gly Ile Tyr Phe 
    130                 135                 140                 


Gly Lys Arg Lys Glu Asp Asp Gly Asp Gly Val Ala Trp Asp Ser Glu 
145                 150                 155                 160 


Gln Tyr Thr Val Pro Glu Val Gln Arg Ile Thr Arg Met Ala Ala Phe 
                165                 170                 175     


Met Ala Leu Gln His Glu Pro Pro Leu Pro Ile Trp Ser Leu Asp Lys 
            180                 185                 190         


Ala Asn Val Leu Ala Ser Ser Arg Leu Trp Arg Lys Thr Val Glu Glu 
        195                 200                 205             


Thr Ile Lys Asn Glu Phe Pro Thr Leu Lys Val Gln His Gln Leu Ile 
    210                 215                 220                 


Asp Ser Ala Ala Met Ile Leu Val Lys Asn Pro Thr His Leu Asn Gly 
225                 230                 235                 240 


Ile Ile Ile Thr Ser Asn Met Phe Gly Asp Ile Ile Ser Asp Glu Ala 
                245                 250                 255     


Ser Val Ile Pro Gly Ser Leu Gly Leu Leu Pro Ser Ala Ser Leu Ala 
            260                 265                 270         


Ser Leu Pro Asp Lys Asn Thr Ala Phe Gly Leu Tyr Glu Pro Cys His 
        275                 280                 285             


Gly Ser Ala Pro Asp Leu Pro Lys Asn Lys Val Asn Pro Ile Ala Thr 
    290                 295                 300                 


Ile Leu Ser Ala Ala Met Met Leu Lys Leu Ser Leu Asn Leu Pro Glu 
305                 310                 315                 320 


Glu Gly Lys Ala Ile Glu Asp Ala Val Lys Lys Val Leu Asp Ala Gly 
                325                 330                 335     


Ile Arg Thr Gly Asp Leu Gly Gly Ser Asn Ser Thr Thr Glu Val Gly 
            340                 345                 350         


Asp Ala Val Ala Glu Glu Val Lys Lys Ile Leu Ala 
        355                 360                 


<210>  27
<211>  1038
<212>  DNA
<213>  Thermus thermophilus

<400>  27
atgaaggtgg ccgtgctccc cggggacggg atcggccccg aggtcaccga ggccgccctg       60

aaggtcctaa gggccctgga cgaggccgag ggcctgggcc tcgcctacga ggtcttcccc      120

ttcggcgggg cggccataga cgccttcggc gagcccttcc ccgagcccac gcgaaagggc      180

gtggaggagg cggaggcggt gcttctggga agcgtggggg ggcccaagtg ggacggcctt      240

ccccgcaaga tccgcccgga gacggggctt ctttccttaa ggaaaagcca ggacctcttc      300

gccaacctcc gcccggccaa ggtcttcccc gggctggaaa ggctttcccc cctgaaggag      360

gagatcgccc ggggggtgga cgtcctcatc gtccgggagc tcaccggggg gatctacttc      420

ggggagcccc gggggatgtc ggaggccgag gcctggaaca cggagcgcta cagcaagccc      480

gaggtggagc gggtggcccg ggtggccttt gaggcggcga ggaagcgcag gaagcacgtg      540

gtgagcgtgg acaaggcgaa cgtcctcgag gtgggggagt tctggcgcaa gaccgtggag      600

gaggtggggc ggggctaccc cgacgtcgcc ctggagcacc agtacgtgga cgccatggcc      660

atgcacctgg tccgctcccc tgcccgcttt gacgtggtgg tcacggggaa catcttcggg      720

gacatcctct cggacctggc gagcgtcctc ccaggctctc taggcctcct cccctccgcc      780

tccttgggaa ggggcacccc ggtctttgag cccgtgcacg gctccgcccc ggacatcgcc      840

ggcaaaggcc tcgccaaccc cacggccgcc atcctctccg cggccatgat gctggagcac      900

gccttcggcc tggtggagct ggcgcggaag gtggaagacg cggtggccaa ggccctcctg      960

gaggccccac cccccgacct cgggggaagc gcgggcacgg aggccttcac ggccacggtc     1020

ctccgccacc tcgcctaa                                                   1038


<210>  28
<211>  345
<212>  PRT
<213>  Thermus thermophilus

<400>  28

Met Lys Val Ala Val Leu Pro Gly Asp Gly Ile Gly Pro Glu Val Thr 
1               5                   10                  15      


Glu Ala Ala Leu Lys Val Leu Arg Ala Leu Asp Glu Ala Glu Gly Leu 
            20                  25                  30          


Gly Leu Ala Tyr Glu Val Phe Pro Phe Gly Gly Ala Ala Ile Asp Ala 
        35                  40                  45              


Phe Gly Glu Pro Phe Pro Glu Pro Thr Arg Lys Gly Val Glu Glu Ala 
    50                  55                  60                  


Glu Ala Val Leu Leu Gly Ser Val Gly Gly Pro Lys Trp Asp Gly Leu 
65                  70                  75                  80  


Pro Arg Lys Ile Arg Pro Glu Thr Gly Leu Leu Ser Leu Arg Lys Ser 
                85                  90                  95      


Gln Asp Leu Phe Ala Asn Leu Arg Pro Ala Lys Val Phe Pro Gly Leu 
            100                 105                 110         


Glu Arg Leu Ser Pro Leu Lys Glu Glu Ile Ala Arg Gly Val Asp Val 
        115                 120                 125             


Leu Ile Val Arg Glu Leu Thr Gly Gly Ile Tyr Phe Gly Glu Pro Arg 
    130                 135                 140                 


Gly Met Ser Glu Ala Glu Ala Trp Asn Thr Glu Arg Tyr Ser Lys Pro 
145                 150                 155                 160 


Glu Val Glu Arg Val Ala Arg Val Ala Phe Glu Ala Ala Arg Lys Arg 
                165                 170                 175     


Arg Lys His Val Val Ser Val Asp Lys Ala Asn Val Leu Glu Val Gly 
            180                 185                 190         


Glu Phe Trp Arg Lys Thr Val Glu Glu Val Gly Arg Gly Tyr Pro Asp 
        195                 200                 205             


Val Ala Leu Glu His Gln Tyr Val Asp Ala Met Ala Met His Leu Val 
    210                 215                 220                 


Arg Ser Pro Ala Arg Phe Asp Val Val Val Thr Gly Asn Ile Phe Gly 
225                 230                 235                 240 


Asp Ile Leu Ser Asp Leu Ala Ser Val Leu Pro Gly Ser Leu Gly Leu 
                245                 250                 255     


Leu Pro Ser Ala Ser Leu Gly Arg Gly Thr Pro Val Phe Glu Pro Val 
            260                 265                 270         


His Gly Ser Ala Pro Asp Ile Ala Gly Lys Gly Leu Ala Asn Pro Thr 
        275                 280                 285             


Ala Ala Ile Leu Ser Ala Ala Met Met Leu Glu His Ala Phe Gly Leu 
    290                 295                 300                 


Val Glu Leu Ala Arg Lys Val Glu Asp Ala Val Ala Lys Ala Leu Leu 
305                 310                 315                 320 


Glu Ala Pro Pro Pro Asp Leu Gly Gly Ser Ala Gly Thr Glu Ala Phe 
                325                 330                 335     


Thr Ala Thr Val Leu Arg His Leu Ala 
            340                 345 


<210>  29
<211>  1038
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TtIPMDH R132H polynucleotide

<400>  29
atgaaggtgg ccgtgctccc cggggacggg atcggccccg aggtcaccga ggccgccctg       60

aaggtcctaa gggccctgga cgaggccgag ggcctgggcc tcgcctacga ggtcttcccc      120

ttcggcgggg cggccataga cgccttcggc gagcccttcc ccgagcccac gcgaaagggc      180

gtggaggagg cggaggcggt gcttctggga agcgtggggg ggcccaagtg ggacggcctt      240

ccccgcaaga tccgcccgga gacggggctt ctttccttaa ggaaaagcca ggacctcttc      300

gccaacctcc gcccggccaa ggtcttcccc gggctggaaa ggctttcccc cctgaaggag      360

gagatcgccc ggggggtgga cgtcctcatc gtccatgagc tcaccggggg gatctacttc      420

ggggagcccc gggggatgtc ggaggccgag gcctggaaca cggagcgcta cagcaagccc      480

gaggtggagc gggtggcccg ggtggccttt gaggcggcga ggaagcgcag gaagcacgtg      540

gtgagcgtgg acaaggcgaa cgtcctcgag gtgggggagt tctggcgcaa gaccgtggag      600

gaggtggggc ggggctaccc cgacgtcgcc ctggagcacc agtacgtgga cgccatggcc      660

atgcacctgg tccgctcccc tgcccgcttt gacgtggtgg tcacggggaa catcttcggg      720

gacatcctct cggacctggc gagcgtcctc ccaggctctc taggcctcct cccctccgcc      780

tccttgggaa ggggcacccc ggtctttgag cccgtgcacg gctccgcccc ggacatcgcc      840

ggcaaaggcc tcgccaaccc cacggccgcc atcctctccg cggccatgat gctggagcac      900

gccttcggcc tggtggagct ggcgcggaag gtggaagacg cggtggccaa ggccctcctg      960

gaggccccac cccccgacct cgggggaagc gcgggcacgg aggccttcac ggccacggtc     1020

ctccgccacc tcgcctaa                                                   1038


<210>  30
<211>  345
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TtIPMDH R132H polypeptide

<400>  30

Met Lys Val Ala Val Leu Pro Gly Asp Gly Ile Gly Pro Glu Val Thr 
1               5                   10                  15      


Glu Ala Ala Leu Lys Val Leu Arg Ala Leu Asp Glu Ala Glu Gly Leu 
            20                  25                  30          


Gly Leu Ala Tyr Glu Val Phe Pro Phe Gly Gly Ala Ala Ile Asp Ala 
        35                  40                  45              


Phe Gly Glu Pro Phe Pro Glu Pro Thr Arg Lys Gly Val Glu Glu Ala 
    50                  55                  60                  


Glu Ala Val Leu Leu Gly Ser Val Gly Gly Pro Lys Trp Asp Gly Leu 
65                  70                  75                  80  


Pro Arg Lys Ile Arg Pro Glu Thr Gly Leu Leu Ser Leu Arg Lys Ser 
                85                  90                  95      


Gln Asp Leu Phe Ala Asn Leu Arg Pro Ala Lys Val Phe Pro Gly Leu 
            100                 105                 110         


Glu Arg Leu Ser Pro Leu Lys Glu Glu Ile Ala Arg Gly Val Asp Val 
        115                 120                 125             


Leu Ile Val His Glu Leu Thr Gly Gly Ile Tyr Phe Gly Glu Pro Arg 
    130                 135                 140                 


Gly Met Ser Glu Ala Glu Ala Trp Asn Thr Glu Arg Tyr Ser Lys Pro 
145                 150                 155                 160 


Glu Val Glu Arg Val Ala Arg Val Ala Phe Glu Ala Ala Arg Lys Arg 
                165                 170                 175     


Arg Lys His Val Val Ser Val Asp Lys Ala Asn Val Leu Glu Val Gly 
            180                 185                 190         


Glu Phe Trp Arg Lys Thr Val Glu Glu Val Gly Arg Gly Tyr Pro Asp 
        195                 200                 205             


Val Ala Leu Glu His Gln Tyr Val Asp Ala Met Ala Met His Leu Val 
    210                 215                 220                 


Arg Ser Pro Ala Arg Phe Asp Val Val Val Thr Gly Asn Ile Phe Gly 
225                 230                 235                 240 


Asp Ile Leu Ser Asp Leu Ala Ser Val Leu Pro Gly Ser Leu Gly Leu 
                245                 250                 255     


Leu Pro Ser Ala Ser Leu Gly Arg Gly Thr Pro Val Phe Glu Pro Val 
            260                 265                 270         


His Gly Ser Ala Pro Asp Ile Ala Gly Lys Gly Leu Ala Asn Pro Thr 
        275                 280                 285             


Ala Ala Ile Leu Ser Ala Ala Met Met Leu Glu His Ala Phe Gly Leu 
    290                 295                 300                 


Val Glu Leu Ala Arg Lys Val Glu Asp Ala Val Ala Lys Ala Leu Leu 
305                 310                 315                 320 


Glu Ala Pro Pro Pro Asp Leu Gly Gly Ser Ala Gly Thr Glu Ala Phe 
                325                 330                 335     


Thr Ala Thr Val Leu Arg His Leu Ala 
            340                 345 


<210>  31
<211>  1086
<212>  DNA
<213>  Escherichia coli

<400>  31
atgatgaaaa cgatgcgtat tgctgcgatc ccgggagacg ggattggcaa agaagtcctt       60

cctgaaggga ttcgcgtgtt acaggctgcc gctgagcgct ggggcttcgc cttgagtttt      120

gagcaaatgg agtgggcgag ctgcgagtat tacagccatc acggtaaaat gatgccggac      180

gactggcatg agcaacttag ccgtttcgac gccatctatt ttggtgccgt cggctggccg      240

gacaccgttc cggaccatat ttcgttgtgg ggttcgctgc tgaaatttcg tcgtgaattc      300

gaccagtacg tcaacctgcg cccggttcgt ctctttcctg gcgttccctg cccgctggcg      360

ggaaaacagc ctggcgacat cgatttttac gtggtcaggg aaaacaccga aggcgaatat      420

tcctcgctcg gcggtagagt gaatgaaggt acagagcatg aagtcgtcat tcaggaatcg      480

gtatttacgc gtcgtggtgt cgatcgcatt ttgcgttatg ccttcgaact tgcgcaaagc      540

cgcccacgta agacgctaac ttctgccact aaatcaaacg gtttagccat cagcatgccg      600

tactgggatg agcgagtgga agcaatggcc gagaattacc cggagatccg ctgggacaag      660

cagcatattg atattctctg cgcgcgtttt gtgatgcagc cggaacgctt cgatgtggtg      720

gtggcgtcca atttgtttgg cgatatcctt tccgatcttg gcccggcctg caccggcacc      780

attggcattg ccccatccgc caacctgaat ccggaacgca ctttcccctc gctcttcgag      840

cctgtccacg gttccgcgcc ggatatctac gggaaaaata ttgctaaccc tatcgccaca      900

atttgggccg gggcaatgat gctcgatttt ctcggcaatg gcgatgagcg tttccagcaa      960

gcgcataacg gtattctggc agcgattgaa gaagtgattg ctcacgggcc gaaaacaccg     1020

gatatgaaag gcagtgccac cacgccacag gttgccgacg cgatttgcaa aattattttg     1080

cgttaa                                                                1086


<210>  32
<211>  361
<212>  PRT
<213>  Escherichia coli

<400>  32

Met Met Lys Thr Met Arg Ile Ala Ala Ile Pro Gly Asp Gly Ile Gly 
1               5                   10                  15      


Lys Glu Val Leu Pro Glu Gly Ile Arg Val Leu Gln Ala Ala Ala Glu 
            20                  25                  30          


Arg Trp Gly Phe Ala Leu Ser Phe Glu Gln Met Glu Trp Ala Ser Cys 
        35                  40                  45              


Glu Tyr Tyr Ser His His Gly Lys Met Met Pro Asp Asp Trp His Glu 
    50                  55                  60                  


Gln Leu Ser Arg Phe Asp Ala Ile Tyr Phe Gly Ala Val Gly Trp Pro 
65                  70                  75                  80  


Asp Thr Val Pro Asp His Ile Ser Leu Trp Gly Ser Leu Leu Lys Phe 
                85                  90                  95      


Arg Arg Glu Phe Asp Gln Tyr Val Asn Leu Arg Pro Val Arg Leu Phe 
            100                 105                 110         


Pro Gly Val Pro Cys Pro Leu Ala Gly Lys Gln Pro Gly Asp Ile Asp 
        115                 120                 125             


Phe Tyr Val Val Arg Glu Asn Thr Glu Gly Glu Tyr Ser Ser Leu Gly 
    130                 135                 140                 


Gly Arg Val Asn Glu Gly Thr Glu His Glu Val Val Ile Gln Glu Ser 
145                 150                 155                 160 


Val Phe Thr Arg Arg Gly Val Asp Arg Ile Leu Arg Tyr Ala Phe Glu 
                165                 170                 175     


Leu Ala Gln Ser Arg Pro Arg Lys Thr Leu Thr Ser Ala Thr Lys Ser 
            180                 185                 190         


Asn Gly Leu Ala Ile Ser Met Pro Tyr Trp Asp Glu Arg Val Glu Ala 
        195                 200                 205             


Met Ala Glu Asn Tyr Pro Glu Ile Arg Trp Asp Lys Gln His Ile Asp 
    210                 215                 220                 


Ile Leu Cys Ala Arg Phe Val Met Gln Pro Glu Arg Phe Asp Val Val 
225                 230                 235                 240 


Val Ala Ser Asn Leu Phe Gly Asp Ile Leu Ser Asp Leu Gly Pro Ala 
                245                 250                 255     


Cys Thr Gly Thr Ile Gly Ile Ala Pro Ser Ala Asn Leu Asn Pro Glu 
            260                 265                 270         


Arg Thr Phe Pro Ser Leu Phe Glu Pro Val His Gly Ser Ala Pro Asp 
        275                 280                 285             


Ile Tyr Gly Lys Asn Ile Ala Asn Pro Ile Ala Thr Ile Trp Ala Gly 
    290                 295                 300                 


Ala Met Met Leu Asp Phe Leu Gly Asn Gly Asp Glu Arg Phe Gln Gln 
305                 310                 315                 320 


Ala His Asn Gly Ile Leu Ala Ala Ile Glu Glu Val Ile Ala His Gly 
                325                 330                 335     


Pro Lys Thr Pro Asp Met Lys Gly Ser Ala Thr Thr Pro Gln Val Ala 
            340                 345                 350         


Asp Ala Ile Cys Lys Ile Ile Leu Arg 
        355                 360     


<210>  33
<211>  1086
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EcTDH R133H polynucleotide

<400>  33
atgatgaaaa cgatgcgtat tgctgcgatc ccgggagacg ggattggcaa agaagtcctt       60

cctgaaggga ttcgcgtgtt acaggctgcc gctgagcgct ggggcttcgc cttgagtttt      120

gagcaaatgg agtgggcgag ctgcgagtat tacagccatc acggtaaaat gatgccggac      180

gactggcatg agcaacttag ccgtttcgac gccatctatt ttggtgccgt cggctggccg      240

gacaccgttc cggaccatat ttcgttgtgg ggttcgctgc tgaaatttcg tcgtgaattc      300

gaccagtacg tcaacctgcg cccggttcgt ctctttcctg gcgttccctg cccgctggcg      360

ggaaaacagc ctggcgacat cgatttttac gtggtccatg aaaacaccga aggcgaatat      420

tcctcgctcg gcggtagagt gaatgaaggt acagagcatg aagtcgtcat tcaggaatcg      480

gtatttacgc gtcgtggtgt cgatcgcatt ttgcgttatg ccttcgaact tgcgcaaagc      540

cgcccacgta agacgctaac ttctgccact aaatcaaacg gtttagccat cagcatgccg      600

tactgggatg agcgagtgga agcaatggcc gagaattacc cggagatccg ctgggacaag      660

cagcatattg atattctctg cgcgcgtttt gtgatgcagc cggaacgctt cgatgtggtg      720

gtggcgtcca atttgtttgg cgatatcctt tccgatcttg gcccggcctg caccggcacc      780

attggcattg ccccatccgc caacctgaat ccggaacgca ctttcccctc gctcttcgag      840

cctgtccacg gttccgcgcc ggatatctac gggaaaaata ttgctaaccc tatcgccaca      900

atttgggccg gggcaatgat gctcgatttt ctcggcaatg gcgatgagcg tttccagcaa      960

gcgcataacg gtattctggc agcgattgaa gaagtgattg ctcacgggcc gaaaacaccg     1020

gatatgaaag gcagtgccac cacgccacag gttgccgacg cgatttgcaa aattattttg     1080

cgttaa                                                                1086


<210>  34
<211>  361
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EcTDH R133H polypeptide

<400>  34

Met Met Lys Thr Met Arg Ile Ala Ala Ile Pro Gly Asp Gly Ile Gly 
1               5                   10                  15      


Lys Glu Val Leu Pro Glu Gly Ile Arg Val Leu Gln Ala Ala Ala Glu 
            20                  25                  30          


Arg Trp Gly Phe Ala Leu Ser Phe Glu Gln Met Glu Trp Ala Ser Cys 
        35                  40                  45              


Glu Tyr Tyr Ser His His Gly Lys Met Met Pro Asp Asp Trp His Glu 
    50                  55                  60                  


Gln Leu Ser Arg Phe Asp Ala Ile Tyr Phe Gly Ala Val Gly Trp Pro 
65                  70                  75                  80  


Asp Thr Val Pro Asp His Ile Ser Leu Trp Gly Ser Leu Leu Lys Phe 
                85                  90                  95      


Arg Arg Glu Phe Asp Gln Tyr Val Asn Leu Arg Pro Val Arg Leu Phe 
            100                 105                 110         


Pro Gly Val Pro Cys Pro Leu Ala Gly Lys Gln Pro Gly Asp Ile Asp 
        115                 120                 125             


Phe Tyr Val Val His Glu Asn Thr Glu Gly Glu Tyr Ser Ser Leu Gly 
    130                 135                 140                 


Gly Arg Val Asn Glu Gly Thr Glu His Glu Val Val Ile Gln Glu Ser 
145                 150                 155                 160 


Val Phe Thr Arg Arg Gly Val Asp Arg Ile Leu Arg Tyr Ala Phe Glu 
                165                 170                 175     


Leu Ala Gln Ser Arg Pro Arg Lys Thr Leu Thr Ser Ala Thr Lys Ser 
            180                 185                 190         


Asn Gly Leu Ala Ile Ser Met Pro Tyr Trp Asp Glu Arg Val Glu Ala 
        195                 200                 205             


Met Ala Glu Asn Tyr Pro Glu Ile Arg Trp Asp Lys Gln His Ile Asp 
    210                 215                 220                 


Ile Leu Cys Ala Arg Phe Val Met Gln Pro Glu Arg Phe Asp Val Val 
225                 230                 235                 240 


Val Ala Ser Asn Leu Phe Gly Asp Ile Leu Ser Asp Leu Gly Pro Ala 
                245                 250                 255     


Cys Thr Gly Thr Ile Gly Ile Ala Pro Ser Ala Asn Leu Asn Pro Glu 
            260                 265                 270         


Arg Thr Phe Pro Ser Leu Phe Glu Pro Val His Gly Ser Ala Pro Asp 
        275                 280                 285             


Ile Tyr Gly Lys Asn Ile Ala Asn Pro Ile Ala Thr Ile Trp Ala Gly 
    290                 295                 300                 


Ala Met Met Leu Asp Phe Leu Gly Asn Gly Asp Glu Arg Phe Gln Gln 
305                 310                 315                 320 


Ala His Asn Gly Ile Leu Ala Ala Ile Glu Glu Val Ile Ala His Gly 
                325                 330                 335     


Pro Lys Thr Pro Asp Met Lys Gly Ser Ala Thr Thr Pro Gln Val Ala 
            340                 345                 350         


Asp Ala Ile Cys Lys Ile Ile Leu Arg 
        355                 360     


<210>  35
<211>  363
<212>  PRT
<213>  Ajellomyces capsulatus

<400>  35

Met Ala Ala Arg Thr Leu Arg Ile Gly Leu Ile Pro Gly Asp Gly Ile 
1               5                   10                  15      


Gly Arg Glu Val Ile Pro Ala Gly Arg Lys Leu Leu Glu Ser Leu Pro 
            20                  25                  30          


Ser Ser Leu Gly Leu Gln Phe Ser Phe Val Asp Leu Glu Ala Gly Tyr 
        35                  40                  45              


Asp Thr Phe Lys Lys Thr Gly Thr Ala Leu Pro Asp Lys Thr Val Glu 
    50                  55                  60                  


Ile Leu Lys Lys Glu Cys Asp Gly Ala Leu Phe Gly Ala Val Ser Ser 
65                  70                  75                  80  


Pro Ser Thr Lys Val Thr Gly Tyr Ser Ser Pro Ile Val Ala Leu His 
                85                  90                  95      


Lys Arg Leu Asp Leu Tyr Ala Asn Val Arg Pro Val Arg Thr Thr Ile 
            100                 105                 110         


Gly Ser Ser Gly Ser Asn Pro Ile Asp Leu Val Ile Val His Glu Asn 
        115                 120                 125             


Thr Glu Asp Leu Tyr Val Lys Asp Glu Lys Thr Phe Asp Ser Pro Asn 
    130                 135                 140                 


Gly Lys Val Ala Glu Ala Ile Lys Arg Ile Ser Glu His Ala Ser Phe 
145                 150                 155                 160 


Arg Ile Ala Thr Met Ala Gly Asp Ile Ala Leu Arg Arg Gln Lys Ile 
                165                 170                 175     


Arg Asp Gly Ala Ala Ala Ser Thr Lys Ser Asn Thr Arg Ser Lys Pro 
            180                 185                 190         


Met Val Thr Ile Thr His Lys Ser Asn Val Leu Ser Gln Thr Asp Gly 
        195                 200                 205             


Leu Phe Arg Glu Thr Ala Arg Arg Ala Leu Ala Gln Pro Cys Phe Ala 
    210                 215                 220                 


Asp Thr Val Ala Val Glu Glu Gln Ile Val Asp Ser Met Val Tyr Lys 
225                 230                 235                 240 


Leu Phe Arg Gln Pro Ser Tyr Tyr Asp Val Ile Val Ala Pro Asn Leu 
                245                 250                 255     


Tyr Gly Asp Ile Leu Ser Asp Gly Ala Ala Ala Leu Val Gly Ser Leu 
            260                 265                 270         


Gly Leu Val Pro Ser Ala Asn Val Ser Glu Lys Phe Ala Ile Gly Glu 
        275                 280                 285             


Pro Cys His Gly Ser Ala Pro Asp Ile Glu Gly Lys Gly Ile Ala Asn 
    290                 295                 300                 


Pro Ile Ala Thr Leu Arg Ser Val Ala Leu Met Leu Glu Phe Leu Gly 
305                 310                 315                 320 


Glu Glu Lys Ala Ala Ala Ser Ile Tyr Lys Ala Val Asp Ala Asn Leu 
                325                 330                 335     


Asp Glu Gly Lys Phe Leu Ser Pro Asp Leu Gly Gly Lys Ala Lys Ala 
            340                 345                 350         


Glu Glu Val Val Ala Asp Val Leu Arg Arg Leu 
        355                 360             


<210>  36
<211>  363
<212>  PRT
<213>  Ajellomyces capsulatus

<400>  36

Met Ala Ala Arg Thr Leu Arg Ile Gly Leu Ile Pro Gly Asp Gly Ile 
1               5                   10                  15      


Gly Arg Glu Val Ile Pro Ala Gly Arg Lys Leu Leu Glu Ser Leu Pro 
            20                  25                  30          


Ser Ser Leu Gly Leu Gln Phe Ser Phe Val Asp Leu Glu Ala Gly Tyr 
        35                  40                  45              


Asp Thr Phe Lys Lys Thr Gly Thr Ala Leu Pro Asp Lys Thr Val Glu 
    50                  55                  60                  


Ile Leu Lys Lys Glu Cys Asp Gly Ala Leu Phe Gly Ala Val Ser Ser 
65                  70                  75                  80  


Pro Ser Thr Lys Val Thr Gly Tyr Ser Ser Pro Ile Val Ala Leu His 
                85                  90                  95      


Lys Arg Leu Asp Leu Tyr Ala Asn Val Arg Pro Val Arg Thr Thr Ile 
            100                 105                 110         


Gly Ser Ser Gly Ser Asn Pro Ile Asp Leu Val Ile Val His Glu Asn 
        115                 120                 125             


Thr Glu Asp Leu Tyr Val Lys Asp Glu Lys Thr Phe Asp Ser Pro Asn 
    130                 135                 140                 


Gly Lys Val Ala Glu Ala Ile Lys Arg Ile Ser Glu His Ala Ser Phe 
145                 150                 155                 160 


Arg Ile Ala Thr Met Ala Gly Asp Ile Ala Leu Arg Arg Gln Lys Ile 
                165                 170                 175     


Arg Asp Gly Ala Ala Ala Ser Thr Lys Ser Asn Thr Arg Ser Lys Pro 
            180                 185                 190         


Met Val Thr Ile Thr His Lys Ser Asn Val Leu Ser Gln Thr Asp Gly 
        195                 200                 205             


Leu Phe Arg Glu Thr Ala Arg Arg Ala Leu Ala Gln Pro Cys Phe Ala 
    210                 215                 220                 


Asp Thr Val Ala Val Glu Glu Gln Ile Val Asp Ser Met Val Tyr Lys 
225                 230                 235                 240 


Leu Phe Arg Gln Pro Ser Tyr Tyr Asp Val Ile Val Ala Pro Asn Leu 
                245                 250                 255     


Tyr Gly Asp Ile Leu Ser Asp Gly Ala Ala Ala Leu Val Gly Ser Leu 
            260                 265                 270         


Gly Leu Val Pro Ser Ala Asn Val Ser Glu Lys Phe Ala Ile Gly Glu 
        275                 280                 285             


Pro Cys His Gly Ser Ala Pro Asp Ile Glu Gly Lys Gly Ile Ala Asn 
    290                 295                 300                 


Pro Ile Ala Thr Leu Arg Ser Val Ala Leu Met Leu Glu Phe Leu Gly 
305                 310                 315                 320 


Glu Glu Lys Ala Ala Ala Ser Ile Tyr Lys Ala Val Asp Ala Asn Leu 
                325                 330                 335     


Asp Glu Gly Lys Phe Leu Ser Pro Asp Leu Gly Gly Lys Ala Lys Ala 
            340                 345                 350         


Glu Glu Val Val Ala Asp Val Leu Arg Arg Leu 
        355                 360             


<210>  37
<211>  363
<212>  PRT
<213>  Ajellomyces dermatitidis

<400>  37

Met Ala Ala Arg Thr Leu Arg Ile Gly Leu Ile Pro Gly Asp Gly Ile 
1               5                   10                  15      


Gly Arg Glu Val Ile Pro Ala Gly Arg Lys Leu Leu Glu Ser Leu Pro 
            20                  25                  30          


Ala Ser Leu Gly Leu Asn Phe Ser Phe Val Asp Leu Glu Ala Gly Tyr 
        35                  40                  45              


Asn Thr Phe Lys Lys Thr Gly Thr Ala Leu Pro Asp Lys Thr Val Glu 
    50                  55                  60                  


Ile Leu Lys Lys Glu Cys Asp Gly Ala Leu Phe Gly Ala Val Ser Ser 
65                  70                  75                  80  


Pro Ser Thr Lys Val Ala Gly Tyr Ser Ser Pro Ile Val Ala Leu His 
                85                  90                  95      


Lys Lys Leu Asp Leu Tyr Ala Asn Val Arg Pro Val Arg Thr Thr Thr 
            100                 105                 110         


Gly Ser Ser Gly Ser Asn Pro Ile Asp Leu Val Ile Val His Glu Asn 
        115                 120                 125             


Thr Glu Asp Leu Tyr Val Lys Asp Glu Lys Thr Tyr Asp Ser Pro Asn 
    130                 135                 140                 


Gly Lys Val Ala Glu Ala Ile Lys Arg Ile Ser Glu His Ala Ser Phe 
145                 150                 155                 160 


Arg Ile Ala Thr Met Ala Gly Asn Ile Ala Leu Arg Arg Gln Lys Ile 
                165                 170                 175     


Arg Asp Thr Ala Ala Ala Ser Asp Asn Val Asn Thr Arg Ser Lys Pro 
            180                 185                 190         


Met Val Thr Ile Thr His Lys Ser Asn Val Leu Ser Gln Thr Asp Gly 
        195                 200                 205             


Leu Phe Arg Glu Thr Ala Arg Arg Ala Leu Ala Gln Pro Leu Phe Ile 
    210                 215                 220                 


Asp Thr Val Ala Val Glu Glu Gln Ile Val Asp Ser Met Val Tyr Lys 
225                 230                 235                 240 


Leu Phe Arg Gln Pro Ser Tyr Tyr Asp Val Ile Val Ala Pro Asn Leu 
                245                 250                 255     


Tyr Gly Asp Ile Leu Ser Asp Gly Ala Ala Ala Leu Val Gly Ser Leu 
            260                 265                 270         


Gly Leu Val Pro Ser Ala Asn Val Ser Asp Asn Phe Ala Ile Gly Glu 
        275                 280                 285             


Pro Cys His Gly Ser Ala Pro Asp Ile Glu Gly Lys Gly Ile Ala Asn 
    290                 295                 300                 


Pro Ile Ala Thr Leu Arg Ser Val Ala Leu Met Leu Glu Phe Leu Gly 
305                 310                 315                 320 


Glu Glu Lys Ala Ala Ala Ile Ile Tyr Lys Ala Val Asp Ala Asn Leu 
                325                 330                 335     


Asp Glu Gly Lys Phe Leu Ser Pro Asp Leu Gly Gly Lys Ala Lys Thr 
            340                 345                 350         


Asp Glu Val Val Ala Asp Val Leu Arg Arg Leu 
        355                 360             


<210>  38
<211>  363
<212>  PRT
<213>  Ajellomyces dermatitidis

<400>  38

Met Ala Ala Arg Thr Leu Arg Ile Gly Leu Ile Pro Gly Asp Gly Ile 
1               5                   10                  15      


Gly Arg Glu Val Ile Pro Ala Gly Arg Lys Leu Leu Glu Ser Leu Pro 
            20                  25                  30          


Ala Ser Leu Gly Leu Asn Phe Ser Phe Val Asp Leu Glu Ala Gly Tyr 
        35                  40                  45              


Asn Thr Phe Lys Lys Thr Gly Thr Ala Leu Pro Asp Lys Thr Val Glu 
    50                  55                  60                  


Ile Leu Lys Lys Glu Cys Asp Gly Ala Leu Phe Gly Ala Val Ser Ser 
65                  70                  75                  80  


Pro Ser Thr Lys Val Ala Gly Tyr Ser Ser Pro Ile Val Ala Leu His 
                85                  90                  95      


Lys Lys Leu Asp Leu Tyr Ala Asn Val Arg Pro Val Arg Thr Thr Thr 
            100                 105                 110         


Gly Ser Ser Gly Ser Asn Pro Ile Asp Leu Val Ile Val His Glu Asn 
        115                 120                 125             


Thr Glu Asp Leu Tyr Val Lys Asp Glu Lys Thr Tyr Asp Ser Pro Asn 
    130                 135                 140                 


Gly Lys Val Ala Glu Ala Ile Lys Arg Ile Ser Glu His Ala Ser Phe 
145                 150                 155                 160 


Arg Ile Ala Thr Met Ala Gly Asn Ile Ala Leu Arg Arg Gln Lys Ile 
                165                 170                 175     


Arg Asp Thr Ala Ala Ala Ser Asp Asn Val Asn Thr Arg Ser Lys Pro 
            180                 185                 190         


Met Val Thr Ile Thr His Lys Ser Asn Val Leu Ser Gln Thr Asp Gly 
        195                 200                 205             


Leu Phe Arg Glu Thr Ala Arg Arg Ala Leu Ala Gln Pro Leu Phe Ile 
    210                 215                 220                 


Asp Thr Val Ala Val Glu Glu Gln Ile Val Asp Ser Met Val Tyr Lys 
225                 230                 235                 240 


Leu Phe Arg Gln Pro Ser Tyr Tyr Asp Val Ile Val Ala Pro Asn Leu 
                245                 250                 255     


Tyr Gly Asp Ile Leu Ser Asp Gly Ala Ala Ala Leu Val Gly Ser Leu 
            260                 265                 270         


Gly Leu Val Pro Ser Ala Asn Val Ser Asp Asn Phe Ala Ile Gly Glu 
        275                 280                 285             


Pro Cys His Gly Ser Ala Pro Asp Ile Glu Gly Lys Gly Ile Ala Asn 
    290                 295                 300                 


Pro Ile Ala Thr Leu Arg Ser Val Ala Leu Met Leu Glu Phe Leu Gly 
305                 310                 315                 320 


Glu Glu Lys Ala Ala Ala Ile Ile Tyr Lys Ala Val Asp Ala Asn Leu 
                325                 330                 335     


Asp Glu Gly Lys Phe Leu Ser Pro Asp Leu Gly Gly Lys Ala Lys Thr 
            340                 345                 350         


Asp Glu Val Val Ala Asp Val Leu Arg Arg Leu 
        355                 360             


<210>  39
<211>  363
<212>  PRT
<213>  Ajellomyces dermatitidis

<400>  39

Met Ala Ala Arg Thr Leu Arg Ile Gly Leu Ile Pro Gly Asp Gly Ile 
1               5                   10                  15      


Gly Arg Glu Val Ile Pro Ala Gly Arg Lys Leu Leu Glu Ser Leu Pro 
            20                  25                  30          


Ala Ser Leu Gly Leu Asn Phe Ser Phe Val Asp Leu Glu Ala Gly Tyr 
        35                  40                  45              


Asn Thr Phe Lys Lys Thr Gly Thr Ala Leu Pro Asp Lys Thr Val Glu 
    50                  55                  60                  


Ile Leu Lys Lys Glu Cys Asp Gly Ala Leu Phe Gly Ala Val Ser Ser 
65                  70                  75                  80  


Pro Ser Thr Lys Val Ala Gly Tyr Ser Ser Pro Ile Val Ala Leu His 
                85                  90                  95      


Lys Lys Leu Asp Leu Tyr Ala Asn Val Arg Pro Val Arg Thr Thr Thr 
            100                 105                 110         


Gly Ser Ser Gly Ser Asn Pro Ile Asp Leu Val Ile Val His Glu Asn 
        115                 120                 125             


Thr Glu Asp Leu Tyr Val Lys Asp Glu Lys Thr Tyr Asp Ser Pro Asn 
    130                 135                 140                 


Gly Lys Val Ala Glu Ala Ile Lys Arg Ile Ser Glu His Ala Ser Phe 
145                 150                 155                 160 


Arg Ile Ala Thr Met Ala Gly Asn Ile Ala Leu Arg Arg Gln Lys Ile 
                165                 170                 175     


Arg Asp Thr Ala Ala Ala Ser Asp Asn Val Asn Thr Arg Ser Lys Pro 
            180                 185                 190         


Met Val Thr Ile Thr His Lys Ser Asn Val Leu Ser Gln Thr Asp Gly 
        195                 200                 205             


Leu Phe Arg Glu Thr Ala Arg Arg Ala Leu Ala Gln Pro Leu Phe Ile 
    210                 215                 220                 


Asp Thr Val Ala Val Glu Glu Gln Ile Val Asp Ser Met Val Tyr Lys 
225                 230                 235                 240 


Leu Phe Arg Gln Pro Ser Tyr Tyr Asp Val Ile Val Ala Pro Asn Leu 
                245                 250                 255     


Tyr Gly Asp Ile Leu Ser Asp Gly Ala Ala Ala Leu Val Gly Ser Leu 
            260                 265                 270         


Gly Leu Val Pro Ser Ala Asn Val Ser Asp Asn Phe Ala Ile Gly Glu 
        275                 280                 285             


Pro Cys His Gly Ser Ala Pro Asp Ile Glu Gly Lys Gly Ile Ala Asn 
    290                 295                 300                 


Pro Ile Ala Thr Leu Arg Ser Val Ala Leu Met Leu Glu Phe Leu Gly 
305                 310                 315                 320 


Glu Glu Lys Ala Ala Ala Ile Ile Tyr Lys Ala Val Asp Ala Asn Leu 
                325                 330                 335     


Asp Glu Gly Lys Phe Leu Ser Pro Asp Leu Gly Gly Lys Ala Lys Thr 
            340                 345                 350         


Asp Glu Val Val Ala Asp Val Leu Arg Arg Leu 
        355                 360             


<210>  40
<211>  363
<212>  PRT
<213>  Ajellomyces dermatitidis

<400>  40

Met Ala Ala Arg Thr Leu Arg Ile Gly Leu Ile Pro Gly Asp Gly Ile 
1               5                   10                  15      


Gly Arg Glu Val Ile Pro Ala Gly Arg Lys Leu Leu Glu Ser Leu Pro 
            20                  25                  30          


Ala Ser Leu Gly Leu Asn Phe Ser Phe Val Asp Leu Glu Ala Gly Tyr 
        35                  40                  45              


Asn Thr Phe Lys Lys Thr Gly Thr Ala Leu Pro Asp Lys Thr Val Glu 
    50                  55                  60                  


Ile Leu Lys Lys Glu Cys Asp Gly Ala Leu Phe Gly Ala Val Ser Ser 
65                  70                  75                  80  


Pro Ser Thr Lys Val Ala Gly Tyr Ser Ser Pro Ile Val Ala Leu His 
                85                  90                  95      


Lys Lys Leu Asp Leu Tyr Ala Asn Val Arg Pro Val Arg Thr Thr Thr 
            100                 105                 110         


Gly Ser Ser Gly Ser Asn Pro Ile Asp Leu Val Ile Val His Glu Asn 
        115                 120                 125             


Thr Glu Asp Leu Tyr Val Lys Asp Glu Lys Thr Tyr Asp Ser Pro Asn 
    130                 135                 140                 


Gly Lys Val Ala Glu Ala Ile Lys Arg Ile Ser Glu His Ala Ser Phe 
145                 150                 155                 160 


Arg Ile Ala Thr Met Ala Gly Asn Ile Ala Leu Arg Arg Gln Lys Ile 
                165                 170                 175     


Arg Asp Thr Ala Ala Ala Ser Asp Asn Val Asn Thr Arg Ser Lys Pro 
            180                 185                 190         


Met Val Thr Ile Thr His Lys Ser Asn Val Leu Ser Gln Thr Asp Gly 
        195                 200                 205             


Leu Phe Arg Glu Thr Ala Arg Arg Ala Leu Ala Gln Pro Leu Phe Ile 
    210                 215                 220                 


Asp Thr Val Ala Val Glu Glu Gln Ile Val Asp Ser Met Val Tyr Lys 
225                 230                 235                 240 


Leu Phe Arg Gln Pro Ser Tyr Tyr Asp Val Ile Val Ala Pro Asn Leu 
                245                 250                 255     


Tyr Gly Asp Ile Leu Ser Asp Gly Ala Ala Ala Leu Val Gly Ser Leu 
            260                 265                 270         


Gly Leu Val Pro Ser Ala Asn Val Ser Asp Asn Phe Ala Ile Gly Glu 
        275                 280                 285             


Pro Cys His Gly Ser Ala Pro Asp Ile Glu Gly Lys Gly Ile Ala Asn 
    290                 295                 300                 


Pro Ile Ala Thr Leu Arg Ser Val Ala Leu Met Leu Glu Phe Leu Gly 
305                 310                 315                 320 


Glu Glu Lys Ala Ala Ala Ile Ile Tyr Lys Ala Val Asp Ala Asn Leu 
                325                 330                 335     


Asp Glu Gly Lys Phe Leu Ser Pro Asp Leu Gly Gly Lys Ala Lys Thr 
            340                 345                 350         


Asp Glu Val Val Ala Asp Val Leu Arg Arg Leu 
        355                 360             


<210>  41
<211>  360
<212>  PRT
<213>  Arthroderma gypseum

<400>  41

Met Ala Ala Arg Thr Leu Arg Ile Gly Leu Ile Pro Gly Asp Gly Ile 
1               5                   10                  15      


Gly Arg Glu Val Ile Pro Ala Gly Arg Arg Ile Leu Glu Ala Leu Pro 
            20                  25                  30          


Ala Ser Leu Gly Leu Lys Phe Thr Phe Val Asp Leu Glu Ala Gly Tyr 
        35                  40                  45              


Asp Thr Phe Leu Arg Thr Lys Thr Ala Leu Pro Asp Lys Thr Val Glu 
    50                  55                  60                  


Thr Leu Lys Lys Glu Cys Asp Gly Ala Leu Phe Gly Ala Val Ser Ser 
65                  70                  75                  80  


Pro Ser Thr Lys Val Ala Gly Tyr Ser Ser Pro Ile Val Ala Leu His 
                85                  90                  95      


Lys Lys Leu Asp Leu Tyr Ala Asn Val Arg Pro Val Lys Thr Thr Ala 
            100                 105                 110         


Gly Ala Asn Ala Ser Val Arg Pro Ile Asp Leu Val Ile Val His Glu 
        115                 120                 125             


Asn Thr Glu Asp Leu Tyr Val Lys Glu Glu Lys Thr Tyr Asp Thr Pro 
    130                 135                 140                 


Asp Gly Lys Val Ala Glu Ala Ile Lys Arg Ile Ser Glu Arg Ala Ser 
145                 150                 155                 160 


Phe Arg Ile Gly Ala Met Ala Gly Glu Ile Ala Leu Arg Arg Gln Lys 
                165                 170                 175     


Ile Arg Gln Ala Gln Ser Ala Asn Thr Thr Thr Thr Glu Pro Met Val 
            180                 185                 190         


Thr Ile Thr His Lys Ser Asn Val Leu Ser Gln Ser Asp Gly Leu Phe 
        195                 200                 205             


Arg Glu Thr Cys Arg Lys Ala Leu Ala Asn Asp Lys Phe Ser Ser Ile 
    210                 215                 220                 


Asn Val Glu Glu Gln Ile Val Asp Ser Met Val Tyr Lys Leu Phe Arg 
225                 230                 235                 240 


Gln Pro Ser Tyr Tyr Asp Val Ile Val Ala Pro Asn Leu Tyr Gly Asp 
                245                 250                 255     


Ile Leu Ser Asp Gly Ala Ala Ala Leu Val Gly Ser Leu Gly Leu Val 
            260                 265                 270         


Pro Ser Ala Asn Val Gly Asp Gly Phe Ala Ile Gly Glu Pro Cys His 
        275                 280                 285             


Gly Ser Ala Pro Asp Ile Glu Gly Lys Gly Ile Ala Asn Pro Ile Ala 
    290                 295                 300                 


Thr Ile Arg Ser Thr Ala Leu Met Leu Glu Phe Leu Gly Glu Gly Glu 
305                 310                 315                 320 


Ala Ala Ala Arg Ile Tyr Ala Ala Val Asp Ala Asn Leu Asp Glu Gly 
                325                 330                 335     


Arg Leu Leu Ser Pro Asp Leu Gly Gly Lys Ala Thr Thr Thr Glu Val 
            340                 345                 350         


Leu Glu Asp Val Leu Lys Lys Leu 
        355                 360 


<210>  42
<211>  360
<212>  PRT
<213>  Arthroderma gypseum

<400>  42

Met Ala Ala Arg Thr Leu Arg Ile Gly Leu Ile Pro Gly Asp Gly Ile 
1               5                   10                  15      


Gly Arg Glu Val Ile Pro Ala Gly Arg Arg Ile Leu Glu Ala Leu Pro 
            20                  25                  30          


Ala Ser Leu Gly Leu Lys Phe Thr Phe Val Asp Leu Glu Ala Gly Tyr 
        35                  40                  45              


Asp Thr Phe Leu Arg Thr Lys Thr Ala Leu Pro Asp Lys Thr Val Glu 
    50                  55                  60                  


Thr Leu Lys Lys Glu Cys Asp Gly Ala Leu Phe Gly Ala Val Ser Ser 
65                  70                  75                  80  


Pro Ser Thr Lys Val Ala Gly Tyr Ser Ser Pro Ile Val Ala Leu His 
                85                  90                  95      


Lys Lys Leu Asp Leu Tyr Ala Asn Val Arg Pro Val Lys Thr Thr Ala 
            100                 105                 110         


Gly Ala Asn Ala Ser Val Arg Pro Ile Asp Leu Val Ile Val His Glu 
        115                 120                 125             


Asn Thr Glu Asp Leu Tyr Val Lys Glu Glu Lys Thr Tyr Asp Thr Pro 
    130                 135                 140                 


Asp Gly Lys Val Ala Glu Ala Ile Lys Arg Ile Ser Glu Arg Ala Ser 
145                 150                 155                 160 


Phe Arg Ile Gly Ala Met Ala Gly Glu Ile Ala Leu Arg Arg Gln Lys 
                165                 170                 175     


Ile Arg Gln Ala Gln Ser Ala Asn Thr Thr Thr Thr Glu Pro Met Val 
            180                 185                 190         


Thr Ile Thr His Lys Ser Asn Val Leu Ser Gln Ser Asp Gly Leu Phe 
        195                 200                 205             


Arg Glu Thr Cys Arg Lys Ala Leu Ala Asn Asp Lys Phe Ser Ser Ile 
    210                 215                 220                 


Asn Val Glu Glu Gln Ile Val Asp Ser Met Val Tyr Lys Leu Phe Arg 
225                 230                 235                 240 


Gln Pro Ser Tyr Tyr Asp Val Ile Val Ala Pro Asn Leu Tyr Gly Asp 
                245                 250                 255     


Ile Leu Ser Asp Gly Ala Ala Ala Leu Val Gly Ser Leu Gly Leu Val 
            260                 265                 270         


Pro Ser Ala Asn Val Gly Asp Gly Phe Ala Ile Gly Glu Pro Cys His 
        275                 280                 285             


Gly Ser Ala Pro Asp Ile Glu Gly Lys Gly Ile Ala Asn Pro Ile Ala 
    290                 295                 300                 


Thr Ile Arg Ser Thr Ala Leu Met Leu Glu Phe Leu Gly Glu Gly Glu 
305                 310                 315                 320 


Ala Ala Ala Arg Ile Tyr Ala Ala Val Asp Ala Asn Leu Asp Glu Gly 
                325                 330                 335     


Arg Leu Leu Ser Pro Asp Leu Gly Gly Lys Ala Thr Thr Thr Glu Val 
            340                 345                 350         


Leu Glu Asp Val Leu Lys Lys Leu 
        355                 360 


<210>  43
<211>  361
<212>  PRT
<213>  Arthroderma otae

<400>  43

Met Ala Ala Arg Thr Leu Arg Ile Gly Leu Ile Pro Gly Asp Gly Ile 
1               5                   10                  15      


Gly Arg Glu Val Ile Pro Ala Gly Arg Arg Ile Leu Glu Ala Leu Pro 
            20                  25                  30          


Ala Ser Leu Gly Leu Lys Phe Ser Phe Val Asp Leu Glu Ala Gly Tyr 
        35                  40                  45              


Asp Thr Phe Leu Arg Thr Lys Thr Ala Leu Pro Asp Lys Thr Val Glu 
    50                  55                  60                  


Thr Leu Lys Lys Glu Cys Asp Gly Ala Leu Phe Gly Ala Val Ser Ser 
65                  70                  75                  80  


Pro Ser Thr Lys Val Ala Gly Tyr Ser Ser Pro Ile Val Ala Leu His 
                85                  90                  95      


Lys Lys Leu Asp Leu Tyr Ala Asn Val Arg Pro Val Lys Thr Thr Ala 
            100                 105                 110         


Gly Ala Asn Ala Ser Ala Arg Pro Ile Asp Leu Val Ile Val His Glu 
        115                 120                 125             


Asn Thr Glu Asp Leu Tyr Val Lys Glu Glu Lys Thr Tyr Asp Thr Pro 
    130                 135                 140                 


Asn Gly Lys Val Ala Glu Ala Ile Lys Arg Ile Ser Glu Arg Ala Ser 
145                 150                 155                 160 


Phe Arg Ile Gly Thr Met Ala Gly Asp Ile Ala Leu Arg Arg Gln Lys 
                165                 170                 175     


Val Arg Asp Ser Gln Gln Ser Thr Ala Thr Ala Thr Thr Ser Pro Met 
            180                 185                 190         


Val Thr Ile Thr His Lys Ser Asn Val Leu Ser Gln Ser Asp Gly Leu 
        195                 200                 205             


Phe Arg Glu Thr Cys Arg Lys Ala Leu Ala Asp Asp Arg Phe Asp Lys 
    210                 215                 220                 


Val His Val Glu Glu Gln Ile Val Asp Ser Met Val Tyr Lys Leu Phe 
225                 230                 235                 240 


Arg Gln Pro Ser Tyr Tyr Asp Val Ile Val Ala Pro Asn Leu Tyr Gly 
                245                 250                 255     


Asp Ile Leu Ser Asp Gly Ala Ala Ala Leu Val Gly Ser Leu Gly Leu 
            260                 265                 270         


Val Pro Ser Ala Asn Val Gly Asp Gly Phe Ala Ile Gly Glu Pro Cys 
        275                 280                 285             


His Gly Ser Ala Pro Asp Ile Glu Gly Gln Gly Ile Ala Asn Pro Ile 
    290                 295                 300                 


Ala Thr Ile Arg Ser Thr Ala Leu Met Leu Glu Phe Leu Gly Glu Gly 
305                 310                 315                 320 


Glu Ala Ala Ala Lys Ile Tyr Ala Ala Val Asp Ala Asn Leu Asp Glu 
                325                 330                 335     


Gly Arg Phe Leu Ser Pro Asp Leu Gly Gly Lys Ala Thr Thr Ala Glu 
            340                 345                 350         


Val Leu Glu Asp Val Leu Gly Lys Leu 
        355                 360     


<210>  44
<211>  361
<212>  PRT
<213>  Arthroderma otae

<400>  44

Met Ala Ala Arg Thr Leu Arg Ile Gly Leu Ile Pro Gly Asp Gly Ile 
1               5                   10                  15      


Gly Arg Glu Val Ile Pro Ala Gly Arg Arg Ile Leu Glu Ala Leu Pro 
            20                  25                  30          


Ala Ser Leu Gly Leu Lys Phe Ser Phe Val Asp Leu Glu Ala Gly Tyr 
        35                  40                  45              


Asp Thr Phe Leu Arg Thr Lys Thr Ala Leu Pro Asp Lys Thr Val Glu 
    50                  55                  60                  


Thr Leu Lys Lys Glu Cys Asp Gly Ala Leu Phe Gly Ala Val Ser Ser 
65                  70                  75                  80  


Pro Ser Thr Lys Val Ala Gly Tyr Ser Ser Pro Ile Val Ala Leu His 
                85                  90                  95      


Lys Lys Leu Asp Leu Tyr Ala Asn Val Arg Pro Val Lys Thr Thr Ala 
            100                 105                 110         


Gly Ala Asn Ala Ser Ala Arg Pro Ile Asp Leu Val Ile Val His Glu 
        115                 120                 125             


Asn Thr Glu Asp Leu Tyr Val Lys Glu Glu Lys Thr Tyr Asp Thr Pro 
    130                 135                 140                 


Asn Gly Lys Val Ala Glu Ala Ile Lys Arg Ile Ser Glu Arg Ala Ser 
145                 150                 155                 160 


Phe Arg Ile Gly Thr Met Ala Gly Asp Ile Ala Leu Arg Arg Gln Lys 
                165                 170                 175     


Val Arg Asp Ser Gln Gln Ser Thr Ala Thr Ala Thr Thr Ser Pro Met 
            180                 185                 190         


Val Thr Ile Thr His Lys Ser Asn Val Leu Ser Gln Ser Asp Gly Leu 
        195                 200                 205             


Phe Arg Glu Thr Cys Arg Lys Ala Leu Ala Asp Asp Arg Phe Asp Lys 
    210                 215                 220                 


Val His Val Glu Glu Gln Ile Val Asp Ser Met Val Tyr Lys Leu Phe 
225                 230                 235                 240 


Arg Gln Pro Ser Tyr Tyr Asp Val Ile Val Ala Pro Asn Leu Tyr Gly 
                245                 250                 255     


Asp Ile Leu Ser Asp Gly Ala Ala Ala Leu Val Gly Ser Leu Gly Leu 
            260                 265                 270         


Val Pro Ser Ala Asn Val Gly Asp Gly Phe Ala Ile Gly Glu Pro Cys 
        275                 280                 285             


His Gly Ser Ala Pro Asp Ile Glu Gly Gln Gly Ile Ala Asn Pro Ile 
    290                 295                 300                 


Ala Thr Ile Arg Ser Thr Ala Leu Met Leu Glu Phe Leu Gly Glu Gly 
305                 310                 315                 320 


Glu Ala Ala Ala Lys Ile Tyr Ala Ala Val Asp Ala Asn Leu Asp Glu 
                325                 330                 335     


Gly Arg Phe Leu Ser Pro Asp Leu Gly Gly Lys Ala Thr Thr Ala Glu 
            340                 345                 350         


Val Leu Glu Asp Val Leu Gly Lys Leu 
        355                 360     


<210>  45
<211>  361
<212>  PRT
<213>  Aspergillus kawachii

<400>  45

Met Ala Ala Ala Ala Arg Thr Leu Arg Ile Gly Leu Ile Pro Gly Asp 
1               5                   10                  15      


Gly Ile Gly Arg Glu Val Ile Pro Ala Gly Arg Lys Val Leu Glu Ser 
            20                  25                  30          


Leu Pro Ser Ser Leu Asn Leu Lys Phe Ser Phe Val Asp Leu Asp Ala 
        35                  40                  45              


Gly Phe Asp Thr Phe Lys Arg Thr Gly Ser Ala Leu Pro Asp Lys Thr 
    50                  55                  60                  


Val Glu Ile Leu Lys Lys Glu Cys Asp Gly Ala Leu Phe Gly Ala Val 
65                  70                  75                  80  


Ser Ser Pro Ser Thr Lys Val Ala Gly Tyr Ser Ser Pro Ile Val Ala 
                85                  90                  95      


Leu His Lys Lys Leu Asp Leu Tyr Ala Asn Val Arg Pro Val Lys Thr 
            100                 105                 110         


Thr Ala Gly Ser Thr Asp Gly Lys Pro Ile Asp Leu Val Ile Val His 
        115                 120                 125             


Glu Asn Thr Glu Asp Leu Tyr Val Lys Glu Glu Gln Thr Lys Glu Thr 
    130                 135                 140                 


Pro Asn Gly Lys Val Ala Glu Ala Ile Lys Arg Ile Ser Glu Asn Ala 
145                 150                 155                 160 


Ser Ser Arg Ile Ser Thr Ile Ala Gly Glu Ile Ala Leu Arg Arg Gln 
                165                 170                 175     


Lys Ile Arg Ser Val Ala Gly Ile Ala Gly Leu Arg Thr Glu Pro Met 
            180                 185                 190         


Val Thr Ile Thr His Lys Ser Asn Val Leu Ser Gln Thr Asp Gly Leu 
        195                 200                 205             


Phe Arg Glu Thr Ala Arg Lys Ala Leu Ser Ala Asp Arg Phe Ser Ser 
    210                 215                 220                 


Val Gln Val Glu Glu Gln Ile Val Asp Ser Met Val Tyr Lys Leu Phe 
225                 230                 235                 240 


Arg Gln Pro Glu Tyr Tyr Asp Val Ile Val Ala Pro Asn Leu Tyr Gly 
                245                 250                 255     


Asp Ile Leu Ser Asp Gly Ala Ala Ala Leu Val Gly Ser Leu Gly Leu 
            260                 265                 270         


Val Pro Ser Ala Asn Val Gly Asp Gly Phe Ala Ile Gly Glu Pro Cys 
        275                 280                 285             


His Gly Ser Ala Pro Asp Ile Glu Gly Lys Gly Ile Ala Asn Pro Ile 
    290                 295                 300                 


Ala Thr Leu Arg Ser Val Ala Leu Met Leu Glu Phe Leu Gly Glu Glu 
305                 310                 315                 320 


Thr Ala Ala Ala Lys Ile Tyr Thr Ala Val Asp Ala Asn Leu Asp Glu 
                325                 330                 335     


Ala Lys Phe Leu Ser Pro Asp Met Gly Gly Lys Ala Thr Thr Gln Glu 
            340                 345                 350         


Val Leu Asp Asp Val Leu Lys Arg Leu 
        355                 360     


<210>  46
<211>  361
<212>  PRT
<213>  Aspergillus niger

<400>  46

Met Ala Ala Ala Ala Arg Thr Leu Arg Ile Gly Leu Ile Pro Gly Asp 
1               5                   10                  15      


Gly Ile Gly Arg Glu Val Ile Pro Ala Gly Arg Lys Val Leu Glu Ser 
            20                  25                  30          


Leu Pro Ser Ser Leu Asn Leu Lys Phe Ser Phe Val Asp Leu Asp Ala 
        35                  40                  45              


Gly Phe Asp Thr Phe Lys Arg Thr Gly Ser Ala Leu Pro Asp Lys Thr 
    50                  55                  60                  


Val Glu Ile Leu Lys Lys Glu Cys Asp Gly Ala Leu Phe Gly Ala Val 
65                  70                  75                  80  


Ser Ser Pro Ser Thr Lys Val Ala Gly Tyr Ser Ser Pro Ile Val Ala 
                85                  90                  95      


Leu His Lys Lys Leu Asp Leu Tyr Ala Asn Val Arg Pro Val Lys Thr 
            100                 105                 110         


Thr Ala Gly Ser Thr Asp Gly Lys Pro Ile Asp Leu Val Ile Val His 
        115                 120                 125             


Glu Asn Thr Glu Asp Leu Tyr Val Lys Glu Glu Gln Thr Lys Glu Thr 
    130                 135                 140                 


Pro Asn Gly Lys Val Ala Glu Ala Ile Lys Arg Ile Ser Glu Asn Ala 
145                 150                 155                 160 


Ser Ser Arg Ile Ser Thr Ile Ala Gly Glu Ile Ala Leu Arg Arg Gln 
                165                 170                 175     


Lys Ile Arg Ser Val Ala Gly Ile Ala Gly Leu Arg Thr Glu Pro Met 
            180                 185                 190         


Val Thr Ile Thr His Lys Ser Asn Val Leu Ser Gln Thr Asp Gly Leu 
        195                 200                 205             


Phe Arg Glu Thr Ala Arg Lys Ala Leu Ser Ala Asp Arg Phe Ser Ser 
    210                 215                 220                 


Val Gln Val Glu Glu Gln Ile Val Asp Ser Met Val Tyr Lys Leu Phe 
225                 230                 235                 240 


Arg Gln Pro Glu Tyr Tyr Asp Val Ile Val Ala Pro Asn Leu Tyr Gly 
                245                 250                 255     


Asp Ile Leu Ser Asp Gly Ala Ala Ala Leu Val Gly Ser Leu Gly Leu 
            260                 265                 270         


Val Pro Ser Ala Asn Val Gly Asp Gly Phe Ala Ile Gly Glu Pro Cys 
        275                 280                 285             


His Gly Ser Ala Pro Asp Ile Glu Gly Lys Gly Ile Ala Asn Pro Ile 
    290                 295                 300                 


Ala Thr Leu Arg Ser Val Ala Leu Met Leu Glu Phe Leu Gly Glu Glu 
305                 310                 315                 320 


Thr Ala Ala Ala Lys Ile Tyr Thr Ala Val Asp Ala Asn Leu Asp Glu 
                325                 330                 335     


Ala Lys Phe Leu Ser Pro Asp Met Gly Gly Lys Ala Thr Thr Gln Glu 
            340                 345                 350         


Val Leu Asp Asp Val Leu Lys Arg Leu 
        355                 360     


<210>  47
<211>  359
<212>  PRT
<213>  Aspergillus oryzae

<400>  47

Met Ala Ala Ala Arg Thr Leu Arg Ile Gly Leu Ile Pro Gly Asp Gly 
1               5                   10                  15      


Ile Gly Arg Glu Val Ile Pro Ala Gly Arg Lys Val Leu Glu Ser Leu 
            20                  25                  30          


Pro Ala Ser Leu Asn Leu Asn Phe Ser Phe Val Asn Leu Asp Ala Gly 
        35                  40                  45              


Phe Asp Thr Phe Lys Gln Thr Gly Thr Ala Leu Pro Asp Lys Thr Val 
    50                  55                  60                  


Glu Thr Leu Lys Lys Glu Cys Asp Gly Ala Leu Phe Gly Ala Val Ser 
65                  70                  75                  80  


Ser Pro Ser Thr Lys Val Ala Gly Tyr Ser Ser Pro Ile Val Ala Leu 
                85                  90                  95      


His Lys Lys Leu Asp Leu Tyr Ala Asn Val Arg Pro Val Lys Ser Thr 
            100                 105                 110         


Ile Gly Gly Gly Arg Asn Pro Val Asp Leu Val Ile Val His Glu Asn 
        115                 120                 125             


Thr Glu Asp Leu Tyr Val Lys Glu Glu Gln Thr Lys Asp Thr Pro Asn 
    130                 135                 140                 


Gly Lys Val Ala Glu Ala Ile Lys Arg Ile Ser Glu Asn Ala Ser Phe 
145                 150                 155                 160 


Arg Ile Ser Ser Ile Ala Gly Glu Ile Ala Leu Arg Arg Gln Lys Ile 
                165                 170                 175     


Arg Asp Ala Ala Ser Thr Thr Gly Leu Arg Thr Lys Pro Met Val Thr 
            180                 185                 190         


Ile Thr His Lys Ser Asn Val Leu Ser Gln Thr Asp Gly Leu Phe Arg 
        195                 200                 205             


Glu Thr Ala Arg Lys Ala Leu Ala Ala Glu Arg Phe Ser Ser Val Glu 
    210                 215                 220                 


Val Glu Glu Gln Ile Val Asp Ser Met Val Tyr Lys Leu Phe Arg Gln 
225                 230                 235                 240 


Pro Glu Tyr Tyr Asp Val Ile Val Ala Pro Asn Leu Tyr Gly Asp Ile 
                245                 250                 255     


Leu Ser Asp Gly Ala Ala Ala Leu Val Gly Ser Leu Gly Leu Val Pro 
            260                 265                 270         


Ser Ala Asn Val Gly Asp Gly Phe Ala Ile Gly Glu Pro Cys His Gly 
        275                 280                 285             


Ser Ala Pro Asp Ile Glu Gly Gln Gly Ile Ala Asn Pro Ile Ala Thr 
    290                 295                 300                 


Leu Arg Ser Ala Ala Leu Met Leu Glu Phe Leu Gly Glu Glu Gly Ala 
305                 310                 315                 320 


Ala Ala Lys Ile Tyr Thr Ala Val Asp Ala Asn Leu Asp Glu Gly Lys 
                325                 330                 335     


Tyr Leu Ser Pro Asp Met Gly Gly Lys Ala Ser Thr Gln Glu Val Leu 
            340                 345                 350         


Asp Asp Val Leu Lys Arg Leu 
        355                 


<210>  48
<211>  403
<212>  PRT
<213>  Aspergillus terreus

<400>  48

Met Val Lys Thr His Pro Ala Ile Thr Ala Gly Ala Thr Leu Ile Arg 
1               5                   10                  15      


Ala Val Gly Phe Pro Leu Ala Pro Ile Val Gly Glu Thr Phe Phe Ser 
            20                  25                  30          


Val Gln Phe Thr Pro Ser Arg His Tyr Cys Ala Met Ala Ala Ala Arg 
        35                  40                  45              


Thr Leu Arg Ile Gly Leu Ile Pro Gly Asp Gly Ile Gly Arg Glu Val 
    50                  55                  60                  


Ile Pro Ala Gly Arg Arg Leu Leu Glu Ser Leu Pro Ser Ser Leu Asn 
65                  70                  75                  80  


Leu Lys Phe Ser Phe Val Asp Leu Asp Ala Gly Phe Asp Thr Phe Lys 
                85                  90                  95      


Arg Thr Gly Thr Ala Leu Pro Asp Lys Thr Val Glu Ile Leu Lys Lys 
            100                 105                 110         


Glu Cys Asp Gly Ala Leu Phe Gly Ala Val Ser Ser Pro Ser Thr Lys 
        115                 120                 125             


Val Ala Gly Tyr Ser Ser Pro Ile Val Ala Leu His Lys Lys Leu Asp 
    130                 135                 140                 


Leu Tyr Ala Asn Val Arg Pro Val Lys Thr Thr Ser Gly Asp Ser Lys 
145                 150                 155                 160 


Gly Asn Pro Ile Asp Leu Val Ile Val His Glu Asn Thr Glu Asp Leu 
                165                 170                 175     


Tyr Val Lys Glu Glu Gln Thr Lys Asp Thr Pro Asn Gly Lys Val Ala 
            180                 185                 190         


Glu Ala Ile Lys Arg Ile Ser Glu Asn Ala Ser Ser Arg Ile Ser Thr 
        195                 200                 205             


Ile Ala Gly Glu Ile Ala Leu Arg Arg Gln Lys Ile Arg Asp Val Ala 
    210                 215                 220                 


Ala Thr Pro Gly Leu Arg Ser Lys Pro Met Val Thr Ile Thr His Lys 
225                 230                 235                 240 


Ser Asn Val Leu Ser Gln Thr Asp Gly Leu Phe Arg Glu Thr Ala Arg 
                245                 250                 255     


Lys Ala Leu Ser Ala Asp Arg Phe Ser Ser Val Glu Val Glu Glu Gln 
            260                 265                 270         


Ile Val Asp Ser Met Val Tyr Lys Leu Phe Arg Gln Pro Glu Tyr Tyr 
        275                 280                 285             


Asp Val Ile Val Ala Pro Asn Leu Tyr Gly Asp Ile Leu Ser Asp Gly 
    290                 295                 300                 


Ala Ala Ala Leu Val Gly Ser Leu Gly Leu Val Pro Ser Ala Asn Val 
305                 310                 315                 320 


Gly Asp Gly Phe Ala Ile Gly Glu Pro Cys His Gly Ser Ala Pro Asp 
                325                 330                 335     


Ile Glu Gly Lys Gly Ile Ala Asn Pro Ile Ala Thr Leu Arg Ser Val 
            340                 345                 350         


Ala Leu Met Leu Glu Phe Leu Gly Glu Glu Asn Ala Ala Ala Lys Ile 
        355                 360                 365             


Tyr Thr Ala Val Asp Ala Asn Leu Asp Glu Gly Lys Tyr Leu Ser Pro 
    370                 375                 380                 


Asp Met Gly Gly Lys Ala Thr Thr Gln Gln Val Leu Asp Asp Val Leu 
385                 390                 395                 400 


Lys Arg Leu 
            


<210>  49
<211>  403
<212>  PRT
<213>  Aspergillus terreus

<400>  49

Met Val Lys Thr His Pro Ala Ile Thr Ala Gly Ala Thr Leu Ile Arg 
1               5                   10                  15      


Ala Val Gly Phe Pro Leu Ala Pro Ile Val Gly Glu Thr Phe Phe Ser 
            20                  25                  30          


Val Gln Phe Thr Pro Ser Arg His Tyr Cys Ala Met Ala Ala Ala Arg 
        35                  40                  45              


Thr Leu Arg Ile Gly Leu Ile Pro Gly Asp Gly Ile Gly Arg Glu Val 
    50                  55                  60                  


Ile Pro Ala Gly Arg Arg Leu Leu Glu Ser Leu Pro Ser Ser Leu Asn 
65                  70                  75                  80  


Leu Lys Phe Ser Phe Val Asp Leu Asp Ala Gly Phe Asp Thr Phe Lys 
                85                  90                  95      


Arg Thr Gly Thr Ala Leu Pro Asp Lys Thr Val Glu Ile Leu Lys Lys 
            100                 105                 110         


Glu Cys Asp Gly Ala Leu Phe Gly Ala Val Ser Ser Pro Ser Thr Lys 
        115                 120                 125             


Val Ala Gly Tyr Ser Ser Pro Ile Val Ala Leu His Lys Lys Leu Asp 
    130                 135                 140                 


Leu Tyr Ala Asn Val Arg Pro Val Lys Thr Thr Ser Gly Asp Ser Lys 
145                 150                 155                 160 


Gly Asn Pro Ile Asp Leu Val Ile Val His Glu Asn Thr Glu Asp Leu 
                165                 170                 175     


Tyr Val Lys Glu Glu Gln Thr Lys Asp Thr Pro Asn Gly Lys Val Ala 
            180                 185                 190         


Glu Ala Ile Lys Arg Ile Ser Glu Asn Ala Ser Ser Arg Ile Ser Thr 
        195                 200                 205             


Ile Ala Gly Glu Ile Ala Leu Arg Arg Gln Lys Ile Arg Asp Val Ala 
    210                 215                 220                 


Ala Thr Pro Gly Leu Arg Ser Lys Pro Met Val Thr Ile Thr His Lys 
225                 230                 235                 240 


Ser Asn Val Leu Ser Gln Thr Asp Gly Leu Phe Arg Glu Thr Ala Arg 
                245                 250                 255     


Lys Ala Leu Ser Ala Asp Arg Phe Ser Ser Val Glu Val Glu Glu Gln 
            260                 265                 270         


Ile Val Asp Ser Met Val Tyr Lys Leu Phe Arg Gln Pro Glu Tyr Tyr 
        275                 280                 285             


Asp Val Ile Val Ala Pro Asn Leu Tyr Gly Asp Ile Leu Ser Asp Gly 
    290                 295                 300                 


Ala Ala Ala Leu Val Gly Ser Leu Gly Leu Val Pro Ser Ala Asn Val 
305                 310                 315                 320 


Gly Asp Gly Phe Ala Ile Gly Glu Pro Cys His Gly Ser Ala Pro Asp 
                325                 330                 335     


Ile Glu Gly Lys Gly Ile Ala Asn Pro Ile Ala Thr Leu Arg Ser Val 
            340                 345                 350         


Ala Leu Met Leu Glu Phe Leu Gly Glu Glu Asn Ala Ala Ala Lys Ile 
        355                 360                 365             


Tyr Thr Ala Val Asp Ala Asn Leu Asp Glu Gly Lys Tyr Leu Ser Pro 
    370                 375                 380                 


Asp Met Gly Gly Lys Ala Thr Thr Gln Gln Val Leu Asp Asp Val Leu 
385                 390                 395                 400 


Lys Arg Leu 
            


<210>  50
<211>  376
<212>  PRT
<213>  Candida albicans

<400>  50

Met Leu Ala Ala Arg Ser Ser Ile Arg Arg Cys Phe Ser Thr Ser Ser 
1               5                   10                  15      


Thr Thr Leu Lys Ser Leu Lys Ile Gly Leu Ile Pro Gly Asp Gly Ile 
            20                  25                  30          


Gly Arg Glu Val Ile Pro Ala Gly Lys Ala Val Leu Glu Asn Leu Pro 
        35                  40                  45              


Ala Lys His Asp Leu Gln Phe Glu Phe Val Asn Leu Asp Ala Gly Phe 
    50                  55                  60                  


Glu Leu Phe Lys Lys Thr Gly Thr Ala Leu Pro Asp Glu Thr Val Asp 
65                  70                  75                  80  


Val Leu Lys Lys Glu Cys Asp Gly Ala Leu Phe Gly Ala Val Ser Ser 
                85                  90                  95      


Pro Thr Thr Lys Val Ala Gly Tyr Ser Ser Pro Ile Val Ala Leu His 
            100                 105                 110         


Lys Lys Leu Gly Leu Tyr Ala Asn Val Arg Pro Val Lys Ser Val Glu 
        115                 120                 125             


Gly Ile Gly Arg Pro Val Asp Met Val Ile Val His Glu Asn Thr Glu 
    130                 135                 140                 


Asp Leu Tyr Ile Lys Glu Glu Arg Val Tyr Lys Lys Glu Asp Gly Thr 
145                 150                 155                 160 


Lys Val Ala Glu Ala Ile Lys Arg Ile Thr Glu Thr Ala Ser Thr Arg 
                165                 170                 175     


Ile Ala Lys Met Ala Tyr Glu Ile Ala Leu Gln Arg Glu Ala Val Arg 
            180                 185                 190         


Lys Gly Thr Ser Gly Lys Gln Leu His Glu Lys Pro Ser Val Thr Val 
        195                 200                 205             


Thr His Lys Ser Asn Val Leu Ser Gln Ser Asp Gly Leu Phe Arg Glu 
    210                 215                 220                 


Thr Cys Arg Ala Val Tyr Asp Ala Asn Ala Asn Glu Tyr Gly Gly Ile 
225                 230                 235                 240 


Glu Tyr Lys Glu Gln Ile Val Asp Ser Met Val Tyr Arg Met Phe Arg 
                245                 250                 255     


Glu Pro Glu Ile Phe Asp Val Val Val Ala Pro Asn Leu Tyr Gly Asp 
            260                 265                 270         


Ile Leu Ser Asp Gly Ala Ala Ala Leu Val Gly Ser Leu Gly Val Val 
        275                 280                 285             


Pro Ser Ala Asn Val Gly Asp Asn Phe Ala Ile Gly Glu Pro Cys His 
    290                 295                 300                 


Gly Ser Ala Pro Asp Ile Glu Gly Lys Gly Ile Ser Asn Pro Val Ala 
305                 310                 315                 320 


Thr Ile Arg Ser Thr Ala Leu Met Leu Glu Phe Met Gly Tyr Pro Glu 
                325                 330                 335     


Ala Ala Ala Thr Ile Tyr Gln Ala Val Asp Ala Asn Leu Ala Glu Asp 
            340                 345                 350         


Lys Ile Lys Thr Pro Asp Leu Gly Gly Asn Ser Thr Thr Gln Glu Val 
        355                 360                 365             


Ile Asp Asp Ile Ile Arg Arg Phe 
    370                 375     


<210>  51
<211>  376
<212>  PRT
<213>  Candida albicans

<400>  51

Met Leu Ala Ala Arg Ser Ser Ile Arg Arg Cys Phe Ser Thr Ser Ser 
1               5                   10                  15      


Thr Thr Leu Lys Ser Leu Lys Ile Gly Leu Ile Pro Gly Asp Gly Ile 
            20                  25                  30          


Gly Arg Glu Val Ile Pro Ala Gly Lys Ala Val Leu Glu Asn Leu Pro 
        35                  40                  45              


Ala Lys His Asp Leu Gln Phe Glu Phe Val Asn Leu Asp Ala Gly Phe 
    50                  55                  60                  


Glu Leu Phe Lys Lys Thr Gly Thr Ala Leu Pro Asp Glu Thr Val Asp 
65                  70                  75                  80  


Val Leu Lys Lys Glu Cys Asp Gly Ala Leu Phe Gly Ala Val Ser Ser 
                85                  90                  95      


Pro Thr Thr Lys Val Ala Gly Tyr Ser Ser Pro Ile Val Ala Leu His 
            100                 105                 110         


Lys Lys Leu Gly Leu Tyr Ala Asn Val Arg Pro Val Lys Ser Val Glu 
        115                 120                 125             


Gly Ile Gly Arg Pro Val Asp Met Val Ile Val His Glu Asn Thr Glu 
    130                 135                 140                 


Asp Leu Tyr Ile Lys Glu Glu Arg Val Tyr Lys Lys Glu Asp Gly Thr 
145                 150                 155                 160 


Lys Val Ala Glu Ala Ile Lys Arg Ile Thr Glu Thr Ala Ser Thr Arg 
                165                 170                 175     


Ile Ala Lys Met Ala Tyr Glu Ile Ala Leu Gln Arg Glu Ala Val Arg 
            180                 185                 190         


Lys Gly Thr Ser Gly Lys Gln Leu His Glu Lys Pro Ser Val Thr Val 
        195                 200                 205             


Thr His Lys Ser Asn Val Leu Ser Gln Ser Asp Gly Leu Phe Arg Glu 
    210                 215                 220                 


Thr Cys Arg Ala Val Tyr Asp Ala Asn Ala Asn Glu Tyr Gly Gly Ile 
225                 230                 235                 240 


Glu Tyr Lys Glu Gln Ile Val Asp Ser Met Val Tyr Arg Met Phe Arg 
                245                 250                 255     


Glu Pro Glu Ile Phe Asp Val Val Val Ala Pro Asn Leu Tyr Gly Asp 
            260                 265                 270         


Ile Leu Ser Asp Gly Ala Ala Ala Leu Val Gly Ser Leu Gly Val Val 
        275                 280                 285             


Pro Ser Ala Asn Val Gly Asp Asn Phe Ala Ile Gly Glu Pro Cys His 
    290                 295                 300                 


Gly Ser Ala Pro Asp Ile Glu Gly Lys Gly Ile Ser Asn Pro Val Ala 
305                 310                 315                 320 


Thr Ile Arg Ser Thr Ala Leu Met Leu Glu Phe Met Gly Tyr Pro Glu 
                325                 330                 335     


Ala Ala Ala Thr Ile Tyr Gln Ala Val Asp Ala Asn Leu Ala Glu Asp 
            340                 345                 350         


Lys Ile Lys Thr Pro Asp Leu Gly Gly Asn Ser Thr Thr Gln Glu Val 
        355                 360                 365             


Ile Asp Asp Ile Ile Arg Arg Phe 
    370                 375     


<210>  52
<211>  376
<212>  PRT
<213>  Candida albicans

<400>  52

Met Leu Ala Ala Arg Ser Ser Ile Arg Arg Cys Phe Ser Thr Ser Ser 
1               5                   10                  15      


Thr Thr Leu Lys Ser Leu Lys Ile Gly Leu Ile Pro Gly Asp Gly Ile 
            20                  25                  30          


Gly Arg Glu Val Ile Pro Ala Gly Lys Ala Val Leu Glu Asn Leu Pro 
        35                  40                  45              


Ala Lys His Asp Leu Gln Phe Glu Phe Val Asn Leu Asp Ala Gly Phe 
    50                  55                  60                  


Glu Leu Phe Lys Lys Thr Gly Thr Ala Leu Pro Asp Glu Thr Val Asp 
65                  70                  75                  80  


Val Leu Lys Lys Glu Cys Asp Gly Ala Leu Phe Gly Ala Val Ser Ser 
                85                  90                  95      


Pro Thr Thr Lys Val Ala Gly Tyr Ser Ser Pro Ile Val Ala Leu His 
            100                 105                 110         


Lys Lys Leu Gly Leu Tyr Ala Asn Val Arg Pro Val Lys Ser Val Glu 
        115                 120                 125             


Gly Ile Gly Arg Pro Val Asp Met Val Ile Val His Glu Asn Thr Glu 
    130                 135                 140                 


Asp Leu Tyr Ile Lys Glu Glu Arg Val Tyr Lys Lys Glu Asp Gly Thr 
145                 150                 155                 160 


Lys Val Ala Glu Ala Ile Lys Arg Ile Thr Glu Thr Ala Ser Thr Arg 
                165                 170                 175     


Ile Ala Lys Met Ala Tyr Glu Ile Ala Leu Gln Arg Glu Ala Val Arg 
            180                 185                 190         


Lys Gly Thr Ser Gly Lys Gln Leu His Glu Lys Pro Ser Val Thr Val 
        195                 200                 205             


Thr His Lys Ser Asn Val Leu Ser Gln Ser Asp Gly Leu Phe Arg Glu 
    210                 215                 220                 


Thr Cys Arg Ala Val Tyr Asp Ala Asn Ala Asn Glu Tyr Gly Gly Ile 
225                 230                 235                 240 


Glu Tyr Lys Glu Gln Ile Val Asp Ser Met Val Tyr Arg Met Phe Arg 
                245                 250                 255     


Glu Pro Glu Ile Phe Asp Val Val Val Ala Pro Asn Leu Tyr Gly Asp 
            260                 265                 270         


Ile Leu Ser Asp Gly Ala Ala Ala Leu Val Gly Ser Leu Gly Val Val 
        275                 280                 285             


Pro Ser Ala Asn Val Gly Asp Asn Phe Ala Ile Gly Glu Pro Cys His 
    290                 295                 300                 


Gly Ser Ala Pro Asp Ile Glu Gly Lys Gly Ile Ser Asn Pro Val Ala 
305                 310                 315                 320 


Thr Ile Arg Ser Thr Ala Leu Met Leu Glu Phe Met Gly Tyr Pro Glu 
                325                 330                 335     


Ala Ala Ala Thr Ile Tyr Gln Ala Val Asp Ala Asn Leu Ala Glu Asp 
            340                 345                 350         


Lys Ile Lys Thr Pro Asp Leu Gly Gly Asn Ser Thr Thr Gln Glu Val 
        355                 360                 365             


Ile Asp Asp Ile Ile Arg Arg Phe 
    370                 375     


<210>  53
<211>  376
<212>  PRT
<213>  Candida albicans

<400>  53

Met Leu Ala Ala Arg Ser Ser Ile Arg Arg Cys Phe Ser Thr Ser Ser 
1               5                   10                  15      


Thr Thr Leu Lys Ser Leu Lys Ile Gly Leu Ile Pro Gly Asp Gly Ile 
            20                  25                  30          


Gly Arg Glu Val Ile Pro Ala Gly Lys Ala Val Leu Glu Asn Leu Pro 
        35                  40                  45              


Ala Lys His Asp Leu Gln Phe Glu Phe Val Asn Leu Asp Ala Gly Phe 
    50                  55                  60                  


Glu Leu Phe Lys Lys Thr Gly Thr Ala Leu Pro Asp Glu Thr Val Asp 
65                  70                  75                  80  


Val Leu Lys Lys Glu Cys Asp Gly Ala Leu Phe Gly Ala Val Ser Ser 
                85                  90                  95      


Pro Thr Thr Lys Val Ala Gly Tyr Ser Ser Pro Ile Val Ala Leu His 
            100                 105                 110         


Lys Lys Leu Gly Leu Tyr Ala Asn Val Arg Pro Val Lys Ser Val Glu 
        115                 120                 125             


Gly Ile Gly Arg Pro Val Asp Met Val Ile Val His Glu Asn Thr Glu 
    130                 135                 140                 


Asp Leu Tyr Ile Lys Glu Glu Arg Val Tyr Lys Lys Glu Asp Gly Thr 
145                 150                 155                 160 


Lys Val Ala Glu Ala Ile Lys Arg Ile Thr Glu Thr Ala Ser Thr Arg 
                165                 170                 175     


Ile Ala Lys Met Ala Tyr Glu Ile Ala Leu Gln Arg Glu Ala Val Arg 
            180                 185                 190         


Lys Gly Thr Ser Gly Lys Gln Leu His Glu Lys Pro Ser Val Thr Val 
        195                 200                 205             


Thr His Lys Ser Asn Val Leu Ser Gln Ser Asp Gly Leu Phe Arg Glu 
    210                 215                 220                 


Thr Cys Arg Ala Val Tyr Asp Ala Asn Ala Asn Glu Tyr Gly Gly Ile 
225                 230                 235                 240 


Glu Tyr Lys Glu Gln Ile Val Asp Ser Met Val Tyr Arg Met Phe Arg 
                245                 250                 255     


Glu Pro Glu Ile Phe Asp Val Val Val Ala Pro Asn Leu Tyr Gly Asp 
            260                 265                 270         


Ile Leu Ser Asp Gly Ala Ala Ala Leu Val Gly Ser Leu Gly Val Val 
        275                 280                 285             


Pro Ser Ala Asn Val Gly Asp Asn Phe Ala Ile Gly Glu Pro Cys His 
    290                 295                 300                 


Gly Ser Ala Pro Asp Ile Glu Gly Lys Gly Ile Ser Asn Pro Val Ala 
305                 310                 315                 320 


Thr Ile Arg Ser Thr Ala Leu Met Leu Glu Phe Met Gly Tyr Pro Glu 
                325                 330                 335     


Ala Ala Ala Thr Ile Tyr Gln Ala Val Asp Ala Asn Leu Ala Glu Asp 
            340                 345                 350         


Lys Ile Lys Thr Pro Asp Leu Gly Gly Asn Ser Thr Thr Gln Glu Val 
        355                 360                 365             


Ile Asp Asp Ile Ile Arg Arg Phe 
    370                 375     


<210>  54
<211>  376
<212>  PRT
<213>  Candida albicans

<400>  54

Met Leu Ala Ala Arg Ser Ser Ile Arg Arg Cys Phe Ser Thr Ser Ser 
1               5                   10                  15      


Thr Thr Leu Lys Ser Leu Lys Ile Gly Leu Ile Ser Gly Asp Gly Ile 
            20                  25                  30          


Gly Arg Glu Val Ile Pro Ala Gly Lys Ala Val Leu Glu Asn Leu Pro 
        35                  40                  45              


Ser Lys His Asp Leu Gln Phe Glu Phe Val Asn Leu Asp Ala Gly Phe 
    50                  55                  60                  


Glu Leu Phe Lys Lys Thr Gly Thr Ala Leu Pro Asp Glu Thr Val Asp 
65                  70                  75                  80  


Val Leu Lys Lys Glu Cys Asp Gly Ala Leu Phe Gly Ala Val Ser Ser 
                85                  90                  95      


Pro Thr Thr Lys Val Ala Gly Tyr Ser Ser Pro Ile Val Ala Leu His 
            100                 105                 110         


Lys Lys Leu Gly Leu Tyr Ala Asn Val Arg Pro Val Lys Ser Val Glu 
        115                 120                 125             


Gly Ile Gly Arg Pro Val Asp Met Val Ile Val His Glu Asn Thr Glu 
    130                 135                 140                 


Asp Leu Tyr Ile Lys Glu Glu Arg Val Tyr Lys Lys Glu Asp Gly Thr 
145                 150                 155                 160 


Lys Val Ala Glu Ala Ile Lys Arg Ile Thr Glu Thr Ala Ser Thr Arg 
                165                 170                 175     


Ile Ala Lys Met Ala Tyr Glu Ile Ala Leu Gln Arg Glu Ala Val Arg 
            180                 185                 190         


Lys Gly Thr Ser Gly Lys Gln Leu His Glu Lys Pro Ser Val Thr Val 
        195                 200                 205             


Thr His Lys Ser Asn Val Leu Ser Gln Ser Asp Gly Leu Phe Arg Glu 
    210                 215                 220                 


Thr Cys Arg Ala Val Tyr Asp Ala Asn Ala Asn Glu Tyr Gly Gly Ile 
225                 230                 235                 240 


Glu Tyr Lys Glu Gln Ile Val Asp Ser Met Val Tyr Arg Met Phe Arg 
                245                 250                 255     


Glu Pro Glu Ile Phe Asp Val Val Val Ala Pro Asn Leu Tyr Gly Asp 
            260                 265                 270         


Ile Leu Ser Asp Gly Ala Ala Ala Leu Val Gly Ser Leu Gly Val Val 
        275                 280                 285             


Pro Ser Ala Asn Val Gly Asp Asn Phe Ala Ile Gly Glu Pro Cys His 
    290                 295                 300                 


Gly Ser Ala Pro Asp Ile Glu Gly Lys Gly Ile Ser Asn Pro Val Ala 
305                 310                 315                 320 


Thr Ile Arg Ser Thr Ala Leu Met Leu Glu Phe Met Gly Tyr Pro Glu 
                325                 330                 335     


Ala Ala Ala Thr Ile Tyr Gln Ala Val Asp Ala Asn Leu Ala Glu Asp 
            340                 345                 350         


Lys Ile Lys Thr Pro Asp Leu Gly Gly Asn Ser Thr Thr Gln Glu Val 
        355                 360                 365             


Ile Asp Asp Ile Ile Arg Arg Phe 
    370                 375     


<210>  55
<211>  376
<212>  PRT
<213>  Candida dubliniensis

<400>  55

Met Leu Ala Ala Arg Ser Ser Ile Arg Arg Cys Phe Ser Thr Thr Ser 
1               5                   10                  15      


Thr Thr Leu Lys Ser Leu Lys Ile Gly Leu Ile Pro Gly Asp Gly Ile 
            20                  25                  30          


Gly Arg Glu Val Ile Pro Ala Gly Lys Ala Val Leu Glu Asn Leu Pro 
        35                  40                  45              


Ala Lys His Asp Leu Gln Phe Glu Phe Val Asn Leu Asp Ala Gly Phe 
    50                  55                  60                  


Glu Leu Phe Lys Lys Thr Gly Thr Ala Leu Pro Asp Glu Thr Val Asp 
65                  70                  75                  80  


Ile Leu Lys Lys Glu Cys Asp Gly Ala Leu Phe Gly Ala Val Ser Ser 
                85                  90                  95      


Pro Thr Thr Lys Val Ala Gly Tyr Ser Ser Pro Ile Val Ala Leu His 
            100                 105                 110         


Lys Lys Leu Gly Leu Tyr Ala Asn Val Arg Pro Val Lys Ser Val Glu 
        115                 120                 125             


Gly Ile Gly Arg Pro Val Asp Met Val Ile Val His Glu Asn Thr Glu 
    130                 135                 140                 


Asp Leu Tyr Ile Lys Glu Glu Arg Val Tyr Lys Lys Glu Asp Gly Thr 
145                 150                 155                 160 


Lys Val Ala Glu Ala Ile Lys Arg Ile Thr Glu Thr Ala Ser Thr Lys 
                165                 170                 175     


Ile Ala Lys Met Ala Phe Glu Ile Ala Leu Gln Arg Glu Ala Val Arg 
            180                 185                 190         


Lys Gly Thr Ser Gly Lys Gln Leu His Glu Lys Pro Ser Val Thr Val 
        195                 200                 205             


Thr His Lys Ser Asn Val Leu Ser Gln Ser Asp Gly Leu Phe Arg Glu 
    210                 215                 220                 


Thr Cys Arg Ala Val Tyr Asp Ala Asn Ala Asn Glu Tyr Gly Gly Ile 
225                 230                 235                 240 


Glu Tyr Lys Glu Gln Ile Val Asp Ser Met Val Tyr Arg Met Phe Arg 
                245                 250                 255     


Glu Pro Glu Ile Phe Asp Val Val Val Ala Pro Asn Leu Tyr Gly Asp 
            260                 265                 270         


Ile Leu Ser Asp Gly Ala Ala Ala Leu Val Gly Ser Leu Gly Val Val 
        275                 280                 285             


Pro Ser Ala Asn Val Gly Asp Ser Phe Ala Ile Gly Glu Pro Cys His 
    290                 295                 300                 


Gly Ser Ala Pro Asp Ile Glu Gly Lys Gly Ile Ser Asn Pro Val Ala 
305                 310                 315                 320 


Thr Ile Arg Ser Thr Ala Leu Met Leu Glu Phe Met Gly Tyr Pro Glu 
                325                 330                 335     


Ala Ala Ala Thr Ile Tyr Gln Ala Val Asp Ala Asn Leu Ala Glu Asp 
            340                 345                 350         


Lys Ile Lys Thr Pro Asp Leu Gly Gly Asn Ser Thr Thr Gln Glu Val 
        355                 360                 365             


Ile Asp Asp Ile Ile Arg Arg Phe 
    370                 375     


<210>  56
<211>  376
<212>  PRT
<213>  Candida dubliniensis

<400>  56

Met Leu Ala Ala Arg Ser Ser Ile Arg Arg Cys Phe Ser Thr Thr Ser 
1               5                   10                  15      


Thr Thr Leu Lys Ser Leu Lys Ile Gly Leu Ile Pro Gly Asp Gly Ile 
            20                  25                  30          


Gly Arg Glu Val Ile Pro Ala Gly Lys Ala Val Leu Glu Asn Leu Pro 
        35                  40                  45              


Ala Lys His Asp Leu Gln Phe Glu Phe Val Asn Leu Asp Ala Gly Phe 
    50                  55                  60                  


Glu Leu Phe Lys Lys Thr Gly Thr Ala Leu Pro Asp Glu Thr Val Asp 
65                  70                  75                  80  


Ile Leu Lys Lys Glu Cys Asp Gly Ala Leu Phe Gly Ala Val Ser Ser 
                85                  90                  95      


Pro Thr Thr Lys Val Ala Gly Tyr Ser Ser Pro Ile Val Ala Leu His 
            100                 105                 110         


Lys Lys Leu Gly Leu Tyr Ala Asn Val Arg Pro Val Lys Ser Val Glu 
        115                 120                 125             


Gly Ile Gly Arg Pro Val Asp Met Val Ile Val His Glu Asn Thr Glu 
    130                 135                 140                 


Asp Leu Tyr Ile Lys Glu Glu Arg Val Tyr Lys Lys Glu Asp Gly Thr 
145                 150                 155                 160 


Lys Val Ala Glu Ala Ile Lys Arg Ile Thr Glu Thr Ala Ser Thr Lys 
                165                 170                 175     


Ile Ala Lys Met Ala Phe Glu Ile Ala Leu Gln Arg Glu Ala Val Arg 
            180                 185                 190         


Lys Gly Thr Ser Gly Lys Gln Leu His Glu Lys Pro Ser Val Thr Val 
        195                 200                 205             


Thr His Lys Ser Asn Val Leu Ser Gln Ser Asp Gly Leu Phe Arg Glu 
    210                 215                 220                 


Thr Cys Arg Ala Val Tyr Asp Ala Asn Ala Asn Glu Tyr Gly Gly Ile 
225                 230                 235                 240 


Glu Tyr Lys Glu Gln Ile Val Asp Ser Met Val Tyr Arg Met Phe Arg 
                245                 250                 255     


Glu Pro Glu Ile Phe Asp Val Val Val Ala Pro Asn Leu Tyr Gly Asp 
            260                 265                 270         


Ile Leu Ser Asp Gly Ala Ala Ala Leu Val Gly Ser Leu Gly Val Val 
        275                 280                 285             


Pro Ser Ala Asn Val Gly Asp Ser Phe Ala Ile Gly Glu Pro Cys His 
    290                 295                 300                 


Gly Ser Ala Pro Asp Ile Glu Gly Lys Gly Ile Ser Asn Pro Val Ala 
305                 310                 315                 320 


Thr Ile Arg Ser Thr Ala Leu Met Leu Glu Phe Met Gly Tyr Pro Glu 
                325                 330                 335     


Ala Ala Ala Thr Ile Tyr Gln Ala Val Asp Ala Asn Leu Ala Glu Asp 
            340                 345                 350         


Lys Ile Lys Thr Pro Asp Leu Gly Gly Asn Ser Thr Thr Gln Glu Val 
        355                 360                 365             


Ile Asp Asp Ile Ile Arg Arg Phe 
    370                 375     


<210>  57
<211>  369
<212>  PRT
<213>  Candida parapsilosis

<400>  57

Met Arg Cys Phe Ser Thr Ser Ala Pro Ala Leu Lys Thr Ile Lys Ile 
1               5                   10                  15      


Gly Leu Ile Pro Gly Asp Gly Ile Gly Arg Glu Val Ile Pro Ala Gly 
            20                  25                  30          


Gln Lys Val Leu Glu Ser Leu Pro Ala Lys Tyr Asp Leu Arg Phe Glu 
        35                  40                  45              


Phe Val Asn Leu Asp Ala Gly Tyr Glu Leu Phe Lys Lys Thr Gly Thr 
    50                  55                  60                  


Ala Leu Pro Asp Lys Thr Val Asp Val Leu Lys Asn Glu Cys Asp Gly 
65                  70                  75                  80  


Ala Leu Phe Gly Ala Val Ser Ser Pro Thr Thr Lys Val Ala Gly Tyr 
                85                  90                  95      


Ser Ser Pro Ile Val Ala Leu His Lys Lys Leu Gly Leu Tyr Ala Asn 
            100                 105                 110         


Val Arg Pro Val Lys Ser Val Lys Gly Ile Gly Arg Pro Val Asp Met 
        115                 120                 125             


Val Ile Val His Glu Asn Thr Glu Asp Leu Tyr Val Lys Glu Glu Lys 
    130                 135                 140                 


Thr Phe Glu Lys Glu Asp Gly Thr Lys Val Ala Glu Ala Ile Lys Arg 
145                 150                 155                 160 


Ile Thr Glu Thr Ala Ser Lys Arg Ile Ala Lys Met Ala Tyr Asp Ile 
                165                 170                 175     


Ala Val Gln Arg Gln Gly Ile Arg Asp Ala Ser Ser Ser Ser Glu Gln 
            180                 185                 190         


Leu His Lys Ser Pro Ser Val Thr Val Thr His Lys Ser Asn Val Leu 
        195                 200                 205             


Ser Gln Ser Asp Gly Leu Phe Arg Glu Ser Cys Arg Glu Val Tyr Asp 
    210                 215                 220                 


Ala Asn Lys Asp Lys Tyr Lys Asp Val Glu Tyr Lys Glu Gln Ile Val 
225                 230                 235                 240 


Asp Ser Met Val Tyr Lys Met Phe Arg Asp Pro Glu Val Phe Asp Val 
                245                 250                 255     


Val Val Ala Pro Asn Leu Tyr Gly Asp Ile Leu Ser Asp Gly Ala Ala 
            260                 265                 270         


Ala Leu Val Gly Ser Leu Gly Val Val Pro Ser Ala Asn Val Gly Asp 
        275                 280                 285             


Ser Phe Ala Ile Gly Glu Pro Cys His Gly Ser Ala Pro Asp Ile Glu 
    290                 295                 300                 


Gly Lys Gly Ile Ser Asn Pro Ile Ala Thr Ile Arg Ser Thr Ala Leu 
305                 310                 315                 320 


Met Leu Glu Phe Met Gly Tyr Pro Glu Ala Ala Ala Lys Ile Tyr Glu 
                325                 330                 335     


Ala Val Asp Ala Asn Leu Ala Glu Asp Lys Ile Lys Thr Pro Asp Leu 
            340                 345                 350         


Gly Gly Gln Ser Ser Thr Asn Glu Val Val Glu Asp Ile Ile Lys Arg 
        355                 360                 365             


Phe 
    


<210>  58
<211>  377
<212>  PRT
<213>  Candida tropicalis

<400>  58

Met Leu Ala Ala Ser Arg Ser Ser Ile Arg Arg Cys Phe Ser Thr Ser 
1               5                   10                  15      


Ala Thr Ala Leu Lys Thr Leu Lys Ile Gly Leu Ile Pro Gly Asp Gly 
            20                  25                  30          


Ile Gly Arg Glu Val Ile Pro Ala Gly Gln Ala Val Leu Glu Asn Leu 
        35                  40                  45              


Pro Ala Lys His Asp Leu Gln Phe Glu Phe Val Asn Leu Asp Ala Gly 
    50                  55                  60                  


Phe Glu Leu Phe Lys Lys Thr Gly Thr Ala Leu Pro Asp Glu Thr Val 
65                  70                  75                  80  


Asp Val Leu Lys Lys Glu Cys Asp Gly Ala Leu Phe Gly Ala Val Ser 
                85                  90                  95      


Ser Pro Thr Thr Lys Val Ala Gly Tyr Ser Ser Pro Ile Val Ala Leu 
            100                 105                 110         


His Lys Lys Met Gly Leu Tyr Ala Asn Val Arg Pro Val Lys Ser Val 
        115                 120                 125             


Glu Gly Ile Gly Arg Pro Val Asp Met Val Ile Val His Glu Asn Thr 
    130                 135                 140                 


Glu Asp Leu Tyr Ile Lys Glu Glu Arg Val Tyr Lys Lys Glu Asp Gly 
145                 150                 155                 160 


Thr Lys Val Ala Glu Ala Ile Lys Arg Ile Thr Glu Thr Ala Ser Thr 
                165                 170                 175     


Arg Ile Ala Lys Met Ala Tyr Asp Ile Ala Leu Gln Arg Glu Ala Val 
            180                 185                 190         


Arg Lys Gly Ser Ser Ala Lys Gln Leu His Asp Lys Pro Ser Val Thr 
        195                 200                 205             


Val Thr His Lys Ser Asn Val Leu Ser Gln Ser Asp Gly Leu Phe Arg 
    210                 215                 220                 


Glu Thr Cys Arg Ala Val Tyr Asp Ala Asn Ile Asn Glu Tyr Gly Gly 
225                 230                 235                 240 


Ile Glu Tyr Lys Glu Gln Ile Val Asp Ser Met Val Tyr Arg Met Phe 
                245                 250                 255     


Arg Glu Pro Glu Ile Phe Asp Val Val Val Ala Pro Asn Leu Tyr Gly 
            260                 265                 270         


Asp Ile Leu Ser Asp Gly Ala Ala Ala Leu Val Gly Ser Leu Gly Val 
        275                 280                 285             


Val Pro Ser Ala Asn Val Gly Asp Asn Phe Ala Ile Gly Glu Pro Cys 
    290                 295                 300                 


His Gly Ser Ala Pro Asp Ile Glu Gly Lys Gly Ile Ser Asn Pro Ile 
305                 310                 315                 320 


Ala Thr Ile Arg Ser Thr Ala Leu Met Leu Glu Phe Met Gly Tyr Pro 
                325                 330                 335     


Glu Ala Ala Ala Thr Ile Tyr Glu Ala Val Asp Ala Asn Leu Ala Glu 
            340                 345                 350         


Asp Lys Ile Lys Thr Pro Asp Leu Gly Gly Asn Ser Thr Thr Gln Asp 
        355                 360                 365             


Val Ile Asn Asp Val Ile Arg Arg Phe 
    370                 375         


<210>  59
<211>  377
<212>  PRT
<213>  Candida tropicalis

<400>  59

Met Leu Ala Ala Ser Arg Ser Ser Ile Arg Arg Cys Phe Ser Thr Ser 
1               5                   10                  15      


Ala Thr Ala Leu Lys Thr Leu Lys Ile Gly Leu Ile Pro Gly Asp Gly 
            20                  25                  30          


Ile Gly Arg Glu Val Ile Pro Ala Gly Gln Ala Val Leu Glu Asn Leu 
        35                  40                  45              


Pro Ala Lys His Asp Leu Gln Phe Glu Phe Val Asn Leu Asp Ala Gly 
    50                  55                  60                  


Phe Glu Leu Phe Lys Lys Thr Gly Thr Ala Leu Pro Asp Glu Thr Val 
65                  70                  75                  80  


Asp Val Leu Lys Lys Glu Cys Asp Gly Ala Leu Phe Gly Ala Val Ser 
                85                  90                  95      


Ser Pro Thr Thr Lys Val Ala Gly Tyr Ser Ser Pro Ile Val Ala Leu 
            100                 105                 110         


His Lys Lys Met Gly Leu Tyr Ala Asn Val Arg Pro Val Lys Ser Val 
        115                 120                 125             


Glu Gly Ile Gly Arg Pro Val Asp Met Val Ile Val His Glu Asn Thr 
    130                 135                 140                 


Glu Asp Leu Tyr Ile Lys Glu Glu Arg Val Tyr Lys Lys Glu Asp Gly 
145                 150                 155                 160 


Thr Lys Val Ala Glu Ala Ile Lys Arg Ile Thr Glu Thr Ala Ser Thr 
                165                 170                 175     


Arg Ile Ala Lys Met Ala Tyr Asp Ile Ala Leu Gln Arg Glu Ala Val 
            180                 185                 190         


Arg Lys Gly Ser Ser Ala Lys Gln Leu His Asp Lys Pro Ser Val Thr 
        195                 200                 205             


Val Thr His Lys Ser Asn Val Leu Ser Gln Ser Asp Gly Leu Phe Arg 
    210                 215                 220                 


Glu Thr Cys Arg Ala Val Tyr Asp Ala Asn Ile Asn Glu Tyr Gly Gly 
225                 230                 235                 240 


Ile Glu Tyr Lys Glu Gln Ile Val Asp Ser Met Val Tyr Arg Met Phe 
                245                 250                 255     


Arg Glu Pro Glu Ile Phe Asp Val Val Val Ala Pro Asn Leu Tyr Gly 
            260                 265                 270         


Asp Ile Leu Ser Asp Gly Ala Ala Ala Leu Val Gly Ser Leu Gly Val 
        275                 280                 285             


Val Pro Ser Ala Asn Val Gly Asp Asn Phe Ala Ile Gly Glu Pro Cys 
    290                 295                 300                 


His Gly Ser Ala Pro Asp Ile Glu Gly Lys Gly Ile Ser Asn Pro Ile 
305                 310                 315                 320 


Ala Thr Ile Arg Ser Thr Ala Leu Met Leu Glu Phe Met Gly Tyr Pro 
                325                 330                 335     


Glu Ala Ala Ala Thr Ile Tyr Glu Ala Val Asp Ala Asn Leu Ala Glu 
            340                 345                 350         


Asp Lys Ile Lys Thr Pro Asp Leu Gly Gly Asn Ser Thr Thr Gln Asp 
        355                 360                 365             


Val Ile Asn Asp Val Ile Arg Arg Phe 
    370                 375         


<210>  60
<211>  359
<212>  PRT
<213>  Chaetomium thermophilum

<400>  60

Met Ala Ala Arg Arg Thr Leu Arg Ile Gly Leu Ile Pro Gly Asp Gly 
1               5                   10                  15      


Ile Gly Lys Glu Val Ile Pro Ala Gly Arg Arg Ile Leu Glu Ala Leu 
            20                  25                  30          


Pro Ala Ser Leu Gly Leu Lys Phe Glu Phe Ile Asp Leu Lys Ala Gly 
        35                  40                  45              


Trp Glu Thr Phe Gln Gln Thr Gly Val Ala Leu Pro Glu Glu Thr Val 
    50                  55                  60                  


Ser Val Leu Lys Ser Asp Cys Asp Gly Ala Leu Phe Gly Ala Val Ser 
65                  70                  75                  80  


Ser Pro Thr Ser Ala Val Lys Gly Tyr Ser Ser Pro Ile Val Ala Leu 
                85                  90                  95      


His Lys Lys Leu Asp Leu Tyr Ala Asn Val Arg Pro Val Lys Thr Val 
            100                 105                 110         


Val Ser Ala Pro Lys Pro Ile Asp Met Val Ile Val His Glu Asn Thr 
        115                 120                 125             


Glu Asp Leu Tyr Val Lys Glu Glu Lys Thr Phe Asp Thr Pro Asn Gly 
    130                 135                 140                 


Lys Val Ala Glu Ala Val Lys Arg Ile Ser Gln Arg Ala Ser Ser Arg 
145                 150                 155                 160 


Ile Ala Thr Met Ala Gly Glu Ile Ala Leu Arg Arg Gln Lys Ile Arg 
                165                 170                 175     


Ala Ala Gly Ser Pro Ser Ile His Lys Gly Pro Leu Val Thr Ile Thr 
            180                 185                 190         


His Lys Ser Asn Val Leu Ser Gln Thr Asp Gly Leu Phe Arg Ser Thr 
        195                 200                 205             


Ala Arg Glu Ala Leu Ala Ala Pro Arg Phe Lys Asp Ala Gly Val Ala 
    210                 215                 220                 


Val Glu Glu Gln Ile Val Asp Ser Met Val Tyr Lys Leu Phe Arg Gln 
225                 230                 235                 240 


Pro Glu Ala Tyr Asp Val Ile Val Ala Pro Asn Leu Tyr Gly Asp Ile 
                245                 250                 255     


Leu Ser Asp Gly Ala Ala Ala Leu Val Gly Ser Leu Gly Leu Val Pro 
            260                 265                 270         


Ser Ala Asn Val Gly Glu Gly Phe Ala Ile Gly Glu Pro Cys His Gly 
        275                 280                 285             


Ser Ala Pro Asp Ile Gln Gly Lys Gly Ile Ala Asn Pro Ile Ala Thr 
    290                 295                 300                 


Leu Arg Ser Ala Ala Leu Met Leu Glu Phe Leu Asn Glu Glu Glu Ala 
305                 310                 315                 320 


Ala Ala Lys Ile Tyr Glu Ala Val Asp Ala Asn Leu Thr Glu Gly Lys 
                325                 330                 335     


Leu Leu Ser Pro Asp Leu Gly Gly Thr Ala Thr Thr Glu Glu Val Val 
            340                 345                 350         


Gln Asp Ile Leu Lys Arg Leu 
        355                 


<210>  61
<211>  362
<212>  PRT
<213>  Coprinopsis cinerea

<400>  61

Met Phe Arg Ala Pro Ile Arg Lys Leu Thr Thr Ala Ala Thr Arg Gln 
1               5                   10                  15      


Ser Leu Lys Ile Gly Leu Ile Pro Ala Asp Gly Ile Gly Lys Glu Val 
            20                  25                  30          


Ile Pro Ala Ala Arg Ala Ala Ile Val Ala Leu Gly Asn Asp Ile Pro 
        35                  40                  45              


Lys Pro Glu Phe Ile Asp Leu Asn Ala Gly Trp Glu Thr Phe Thr Arg 
    50                  55                  60                  


Thr Gly Val Ala Leu Pro Glu Glu Thr Val Arg Val Leu His Glu Glu 
65                  70                  75                  80  


Cys Asp Cys Ala Leu Phe Gly Ser Val Ser Ser Pro Ser Arg Lys Val 
                85                  90                  95      


Thr Gly Tyr Ser Ser Pro Ile Val Ala Leu His Lys Glu Leu Asp Leu 
            100                 105                 110         


Tyr Ala Asn Ile Arg Pro Val Thr Ser Val Ala Pro Glu Ala Gly Gln 
        115                 120                 125             


Gln Pro Ala Val Asp Leu Ile Val Val Arg Glu Asn Thr Glu Cys Leu 
    130                 135                 140                 


Tyr Val Lys Gln Glu Gln Gln Thr Ile Gly Glu Asn Gly Lys Glu Ala 
145                 150                 155                 160 


Arg Ala Thr Arg Leu Ile Thr Glu Arg Ala Ser Arg Arg Ile Gly Gln 
                165                 170                 175     


Met Ala Phe Glu Leu Ala Ala Ala Arg Pro Arg Lys His Leu Thr Val 
            180                 185                 190         


Ile His Lys Ser Asn Val Leu Ser Ile Thr Asp Gly Leu Phe Arg Glu 
        195                 200                 205             


Thr Val Arg Ala Val Pro Arg Leu Pro Glu Val Asn Gly Lys Tyr Asp 
    210                 215                 220                 


Asp Val Thr Ile Met Glu Gln Leu Val Asp Ser Ala Val Tyr Arg Leu 
225                 230                 235                 240 


Phe Arg Glu Pro Glu Val Phe Asp Val Met Val Ala Pro Asn Leu Tyr 
                245                 250                 255     


Gly Asp Ile Ile Ser Asp Ala Ala Ala Ala Leu Val Gly Ser Leu Gly 
            260                 265                 270         


Leu Ile Pro Ser Val Asn Ala Gly Asp Asn Phe Val Met Gly Glu Pro 
        275                 280                 285             


Val His Gly Ser Ala Pro Asp Ile Glu Gly Lys Gly Ile Ala Asn Pro 
    290                 295                 300                 


Ile Ala Ser Ile Arg Ser Ala Ala Leu Met Leu Arg His Leu Gly Tyr 
305                 310                 315                 320 


Thr Lys Gly Ala Asp Arg Leu Asp Leu Ala Val Asp Gln Val Ile Arg 
                325                 330                 335     


Glu Gly Lys Tyr Leu Thr Pro Asp Leu Lys Gly Lys Ser Thr Thr Arg 
            340                 345                 350         


Glu Val Leu Asp Ala Val Leu Ala Lys Ile 
        355                 360         


<210>  62
<211>  362
<212>  PRT
<213>  Coprinopsis cinerea

<400>  62

Met Phe Arg Ala Pro Ile Arg Lys Leu Thr Thr Ala Ala Thr Arg Gln 
1               5                   10                  15      


Ser Leu Lys Ile Gly Leu Ile Pro Ala Asp Gly Ile Gly Lys Glu Val 
            20                  25                  30          


Ile Pro Ala Ala Arg Ala Ala Ile Val Ala Leu Gly Asn Asp Ile Pro 
        35                  40                  45              


Lys Pro Glu Phe Ile Asp Leu Asn Ala Gly Trp Glu Thr Phe Thr Arg 
    50                  55                  60                  


Thr Gly Val Ala Leu Pro Glu Glu Thr Val Arg Val Leu Arg Glu Glu 
65                  70                  75                  80  


Cys Asp Cys Ala Leu Phe Gly Ser Val Ser Ser Pro Ser Arg Lys Val 
                85                  90                  95      


Thr Gly Tyr Ser Ser Pro Ile Val Ala Leu His Lys Glu Leu Asp Leu 
            100                 105                 110         


Tyr Ala Asn Ile Arg Pro Val Thr Ser Val Ala Pro Glu Ala Gly Gln 
        115                 120                 125             


Gln Pro Ala Val Asp Leu Ile Val Val His Glu Asn Thr Glu Cys Leu 
    130                 135                 140                 


Tyr Val Lys Gln Glu Gln Gln Thr Ile Gly Glu Asn Gly Lys Glu Ala 
145                 150                 155                 160 


Arg Ala Thr Arg Leu Ile Thr Glu Arg Ala Ser Arg Arg Ile Gly Gln 
                165                 170                 175     


Met Ala Phe Glu Leu Ala Ala Ala Arg Pro Arg Lys His Leu Thr Val 
            180                 185                 190         


Ile His Lys Ser Asn Val Leu Ser Ile Thr Asp Gly Leu Phe Arg Glu 
        195                 200                 205             


Thr Val Arg Ala Val Pro Arg Leu Pro Glu Val Asn Gly Lys Tyr Asp 
    210                 215                 220                 


Asp Val Thr Ile Met Glu Gln Leu Val Asp Ser Ala Val Tyr Arg Leu 
225                 230                 235                 240 


Phe Arg Glu Pro Glu Val Phe Asp Val Met Val Ala Pro Asn Leu Tyr 
                245                 250                 255     


Gly Asp Ile Ile Ser Asp Ala Ala Ala Ala Leu Val Gly Ser Leu Gly 
            260                 265                 270         


Leu Ile Pro Ser Val Asn Ala Gly Asp Asn Phe Val Met Gly Glu Pro 
        275                 280                 285             


Val His Gly Ser Ala Pro Asp Ile Glu Gly Lys Gly Ile Ala Asn Pro 
    290                 295                 300                 


Ile Ala Ser Ile Arg Ser Ala Ala Leu Met Leu Arg His Leu Gly Tyr 
305                 310                 315                 320 


Thr Lys Gly Ala Asp Arg Leu Asp Leu Ala Val Asp Gln Val Ile Arg 
                325                 330                 335     


Glu Gly Lys Tyr Leu Thr Pro Asp Leu Lys Gly Lys Ser Thr Thr Arg 
            340                 345                 350         


Glu Val Leu Asp Ala Val Leu Ala Lys Ile 
        355                 360         


<210>  63
<211>  356
<212>  PRT
<213>  Cordyceps militaris

<400>  63

Met Ser Leu Arg Thr Leu Arg Ile Gly Leu Ile Pro Gly Asp Gly Ile 
1               5                   10                  15      


Gly Lys Glu Val Ile Pro Ala Gly Arg Arg Val Leu Glu Ala Leu Pro 
            20                  25                  30          


Ala Ala Leu Lys Leu Lys Phe Asp Phe Val Asn Leu His Ala Gly Phe 
        35                  40                  45              


Glu Thr Phe Glu Lys Thr Gly Thr Ala Leu Pro Asp Ala Thr Val Asp 
    50                  55                  60                  


Thr Leu Arg Ser Glu Cys Gln Gly Ala Leu Phe Gly Ala Val Ser Ser 
65                  70                  75                  80  


Pro Thr His Ala Val Ala Gly Tyr Ser Ser Pro Ile Val Ala Leu His 
                85                  90                  95      


Lys Arg Leu Asp Leu Tyr Ala Asn Val Arg Pro Val Lys Thr Val Leu 
            100                 105                 110         


Thr Ala Pro Lys Pro Ile Asp Met Val Ile Val His Glu Asn Thr Glu 
        115                 120                 125             


Asp Leu Tyr Val Lys Glu Glu Thr Thr Arg Gln Thr Pro Glu Gly Arg 
    130                 135                 140                 


Val Ala Glu Ala Ile Lys Arg Ile Ser Glu Arg Ala Thr Phe Arg Ile 
145                 150                 155                 160 


Ala Thr Met Ala Gly Asp Ile Ala Val Arg Arg Gln Lys Leu Arg Glu 
                165                 170                 175     


Ala Gly Ala Ala Ser Ile His Lys Ser Pro Val Val Thr Ile Thr His 
            180                 185                 190         


Lys Ser Asn Val Leu Ser Gln Thr Asp Gly Leu Phe Arg Glu Val Ser 
        195                 200                 205             


Lys Thr Ala Leu Ala Asp Pro Arg Phe Ala Ser Val Ala Val Glu Glu 
    210                 215                 220                 


Gln Ile Val Asp Ser Met Val Tyr Lys Leu Phe Arg Gln Pro Glu Asp 
225                 230                 235                 240 


Tyr Asp Val Ile Val Ala Pro Asn Leu Tyr Gly Asp Ile Leu Ser Asp 
                245                 250                 255     


Gly Ala Ala Ala Leu Val Gly Ser Leu Gly Leu Val Pro Ser Ala Asn 
            260                 265                 270         


Val Gly Glu Gly Phe Ala Ile Gly Glu Pro Cys His Gly Ser Ala Pro 
        275                 280                 285             


Asp Ile Met Gly Arg Gly Val Ala Asn Pro Ile Ala Thr Ile Arg Ser 
    290                 295                 300                 


Ala Ala Leu Met Leu Glu Phe Leu Glu Glu Pro Ala Ala Ala Ala Ala 
305                 310                 315                 320 


Ile Tyr Ala Ala Val Asp Ala Asn Leu Glu Glu Gly Lys Leu Leu Ser 
                325                 330                 335     


Pro Asp Leu Gly Gly Thr Ala Thr Thr Glu Gln Val Val Glu Asp Ile 
            340                 345                 350         


Leu Arg Arg Leu 
        355     


<210>  64
<211>  333
<212>  PRT
<213>  Deinococcus radiodurans


<220>
<221>  misc_feature
<222>  (309)..(309)
<223>  Xaa can be any naturally occurring amino acid

<400>  64

Met Ala Lys Tyr Arg Ile Cys Leu Ile Glu Gly Asp Gly Ile Gly His 
1               5                   10                  15      


Glu Val Ile Pro Ala Ala Lys Arg Val Leu Glu Ala Ala Gly Phe Asp 
            20                  25                  30          


Ala Glu Tyr Val His Ala Glu Ala Gly Tyr Glu Tyr Phe Leu Asp His 
        35                  40                  45              


Gly Thr Ser Val Pro Glu Ala Thr Tyr Asp Ala Val Glu Asn Thr Asp 
    50                  55                  60                  


Ala Thr Leu Phe Gly Ala Ala Thr Ser Pro Ser Gly Glu Lys Pro Ala 
65                  70                  75                  80  


Gly Phe Phe Gly Ala Ile Arg His Leu His Gln Lys Tyr Asn Leu Tyr 
                85                  90                  95      


Ala Asn Val Arg Pro Thr Lys Thr Arg Pro Val Pro His Ser Tyr Glu 
            100                 105                 110         


Asn Val Asp Leu Val Ile Val His Glu Asn Thr Gln Gly Leu Tyr Val 
        115                 120                 125             


Glu Gln Glu Arg Arg Tyr Gly Asp Thr Ala Ile Ala Asp Thr Val Ile 
    130                 135                 140                 


Thr Arg Glu Ala Ser Asp Arg Ile Gly Lys Phe Ala Ala Asp Leu Ala 
145                 150                 155                 160 


Met Lys Arg Ser Lys Arg Leu Thr Val Val His Lys Ser Asn Val Leu 
                165                 170                 175     


Pro Val Thr Gln Gly Leu Phe Met Asn Thr Ile Leu Asp His Thr Lys 
            180                 185                 190         


Thr Val Glu Gly Leu Ser Thr Ser Thr Met Ile Val Asp Asn Ala Ala 
        195                 200                 205             


Met Gln Leu Val Arg Asn Pro Gln Gln Phe Asp Val Met Val Met Thr 
    210                 215                 220                 


Asn Met Phe Gly Asp Ile Leu Ser Asp Leu Ala Ala Gly Leu Val Gly 
225                 230                 235                 240 


Gly Leu Gly Ile Ala Ala Ser Gly Asn Val Gly Asp Gln Phe Gly Ile 
                245                 250                 255     


Phe Glu Ser Val His Gly Ser Ala Pro Asp Ile Ala Gly Gln Gly Ile 
            260                 265                 270         


Ser Asn Pro Thr Ala Thr Ile Leu Ala Ala Val Ile Met Leu Asp His 
        275                 280                 285             


Leu Gly Asp His Glu Thr Ala Arg Arg Leu Asp Asn Ala Ile Asn Lys 
    290                 295                 300                 


Val Leu Ala Glu Xaa Pro Arg Thr Arg Asp Leu Gly Gly Thr Ala Gly 
305                 310                 315                 320 


Thr Gln Glu Phe Thr Glu Ala Val Ile Lys Ala Leu Ala 
                325                 330             


<210>  65
<211>  357
<212>  PRT
<213>  Glarea lozoyensis

<400>  65

Met Ala Ala Arg Thr Leu Arg Ile Gly Leu Ile Pro Gly Asp Gly Ile 
1               5                   10                  15      


Gly Lys Glu Val Ile Pro Ala Gly Arg Lys Ile Leu Glu Ala Leu Pro 
            20                  25                  30          


Ala Ser Leu Lys Leu Lys Phe Glu Phe Val Asp Leu Lys Ala Gly Phe 
        35                  40                  45              


Glu Ala Phe Glu Gln Thr Gly Ala Ala Leu Pro Glu Lys Thr Val Glu 
    50                  55                  60                  


Ile Leu Lys Asn Glu Cys Asp Gly Ala Leu Phe Gly Ala Val Ser Ser 
65                  70                  75                  80  


Pro Ser Lys Ala Val Lys Gly Tyr Ser Ser Pro Ile Val Ala Leu His 
                85                  90                  95      


Lys Arg Leu Asp Leu Tyr Ala Asn Val Arg Pro Val Lys Ser Val Met 
            100                 105                 110         


Thr Ala Lys Asn Pro Ile Asp Met Val Ile Val His Glu Asn Thr Glu 
        115                 120                 125             


Asp Val Tyr Val Lys Glu Glu Lys Thr Tyr Asp Thr Pro Glu Gly Lys 
    130                 135                 140                 


Val Ala Glu Ala Ile Lys Arg Ile Ser Glu Lys Ala Ser Phe Arg Ile 
145                 150                 155                 160 


Ala Thr Met Ala Gly Glu Ile Ala Leu Arg Arg Gln Lys Ile Arg Asp 
                165                 170                 175     


Ser Gly Val Pro Ser Ile His Lys Ser Pro Met Val Thr Ile Thr His 
            180                 185                 190         


Lys Ser Asn Val Leu Ser Gln Thr Asp Gly Leu Phe Arg Ser Thr Ala 
        195                 200                 205             


Arg Glu Ala Leu Ala Ala His Lys Phe Ala Ser Ser Val Gly Val Glu 
    210                 215                 220                 


Glu Gln Ile Val Asp Ser Met Val Tyr Lys Leu Phe Arg Gln Pro Glu 
225                 230                 235                 240 


Thr Tyr Asp Val Ile Val Ala Pro Asn Phe Tyr Gly Asp Ile Leu Ser 
                245                 250                 255     


Asp Gly Ala Ala Ala Leu Val Gly Ser Leu Gly Leu Val Pro Ser Ala 
            260                 265                 270         


Asn Val Gly Glu Gly Phe Ala Ile Gly Glu Pro Cys His Gly Ser Ala 
        275                 280                 285             


Pro Asp Ile Met Gly Gln Asp Ile Ala Asn Pro Ile Ala Thr Leu Arg 
    290                 295                 300                 


Ser Val Ala Leu Met Leu Glu Phe Leu Asp Glu Glu Val Ala Ala Ala 
305                 310                 315                 320 


Lys Ile Tyr Ser Ala Val Asp Ala Asn Leu Glu Glu Gly Arg Leu Leu 
                325                 330                 335     


Ser Pro Asp Leu Gly Gly Thr Ala Ser Thr Thr Gln Val Val Glu Asp 
            340                 345                 350         


Ile Leu Arg Arg Leu 
        355         


<210>  66
<211>  370
<212>  PRT
<213>  Komagataella pastoris

<400>  66

Met Leu Ser Ala Val Arg Asn Asn Val Arg Ser Tyr Ser Thr Ala Val 
1               5                   10                  15      


Lys Thr Leu Lys Ile Gly Leu Ile Pro Gly Asp Gly Ile Gly Arg Glu 
            20                  25                  30          


Val Ile Pro Ala Gly Lys Gln Ile Leu Glu Ala Leu Pro Ala Glu His 
        35                  40                  45              


Gly Leu Lys Phe Glu Phe Gln Asn Leu Asp Ala Gly Phe Glu Leu Phe 
    50                  55                  60                  


Lys Lys Thr Gly Val Ala Leu Pro Asp Ala Thr Val Glu Ala Leu Lys 
65                  70                  75                  80  


Gln Asn Cys Asp Gly Ala Leu Phe Gly Ala Val Ser Ser Pro Thr Thr 
                85                  90                  95      


Lys Val Glu Gly Tyr Ser Ser Pro Ile Val Ala Leu His Lys Lys Met 
            100                 105                 110         


Gly Leu Tyr Ala Asn Val Arg Pro Val Lys Ser Val Glu Gly Ile Gly 
        115                 120                 125             


Arg Pro Val Asp Met Val Ile Val His Glu Asn Thr Glu Asp Leu Tyr 
    130                 135                 140                 


Ile Lys Glu Glu Arg Val Tyr Glu Lys Asp Gly Gln Lys Ile Ala Glu 
145                 150                 155                 160 


Ala Ile Lys Arg Ile Ser Glu Asn Ala Thr Asn Lys Ile Gly Lys Met 
                165                 170                 175     


Ala Leu Glu Ile Ala Leu Gln Arg Gln Ala Val Arg Glu Leu Gly Gly 
            180                 185                 190         


Thr Ser Leu His Ser Lys Pro Ser Leu Thr Val Thr His Lys Ser Asn 
        195                 200                 205             


Val Leu Ala Leu Ser Asp Gly Leu Phe Arg Glu Thr Ile Lys Lys Leu 
    210                 215                 220                 


Tyr Asp Ser Asn Ser Lys Tyr Ala Ser Ile Glu Tyr Lys Glu Gln Ile 
225                 230                 235                 240 


Val Asp Ser Met Val Tyr Arg Met Phe Arg Glu Pro Glu Ile Phe Asp 
                245                 250                 255     


Val Val Val Ala Pro Asn Leu Tyr Gly Asp Ile Leu Ser Asp Gly Ala 
            260                 265                 270         


Ala Ala Leu Val Gly Ser Leu Gly Val Val Pro Ser Ala Asn Val Gly 
        275                 280                 285             


Asp Asp Phe Ala Ile Gly Glu Pro Cys His Gly Ser Ala Pro Asp Ile 
    290                 295                 300                 


Glu Gly Lys Gly Ile Ser Asn Pro Val Ala Thr Ile Arg Ser Thr Ala 
305                 310                 315                 320 


Leu Met Leu Glu Phe Met Gly Tyr Pro Lys Ala Ala Ala Gln Ile Tyr 
                325                 330                 335     


Ala Ala Val Asp Ser Asn Leu Ala Glu Asp Lys Ile Lys Thr Pro Asp 
            340                 345                 350         


Leu Asn Gly Lys Ser Thr Thr Gln Glu Val Val Asp Asp Ile Ile Arg 
        355                 360                 365             


Arg Phe 
    370 


<210>  67
<211>  377
<212>  PRT
<213>  Lodderomyces elongisporus

<400>  67

Met Leu Ser Thr Ser His Ser Ile Lys Arg Cys Phe Ser Thr Ser Ser 
1               5                   10                  15      


Pro Leu Leu Lys Thr Leu Lys Ile Gly Leu Ile Pro Gly Asp Gly Ile 
            20                  25                  30          


Gly Arg Glu Val Ile Pro Ala Gly Gln Lys Val Leu Glu Ser Leu Pro 
        35                  40                  45              


Ser Lys Phe Asp Leu Gln Phe Glu Phe Val Asn Leu Asp Ala Gly Phe 
    50                  55                  60                  


Glu Leu Phe Lys Lys Thr Gly Thr Ala Leu Pro Asp Gln Thr Val Glu 
65                  70                  75                  80  


Thr Leu Lys Asn Glu Cys Asp Gly Ala Leu Phe Gly Ala Val Ser Ser 
                85                  90                  95      


Pro Thr Thr Lys Val Glu Gly Tyr Ser Ser Pro Ile Val Ala Leu His 
            100                 105                 110         


Lys Lys Leu Gly Leu Tyr Ala Asn Val Arg Pro Val Lys Ser Val Lys 
        115                 120                 125             


Gly Val Gly Arg Pro Val Asp Met Val Ile Val His Glu Asn Thr Glu 
    130                 135                 140                 


Asp Leu Tyr Val Lys Glu Glu Lys Thr Tyr Gln Lys Glu Asp Gly Thr 
145                 150                 155                 160 


Lys Val Ala Glu Ala Ile Lys Arg Ile Ser Glu Thr Ala Ser Lys Arg 
                165                 170                 175     


Ile Ala Lys Met Ala Tyr Asp Ile Ala Leu Gln Arg Gln Ala Ile Arg 
            180                 185                 190         


Asp Ala Ser Pro Gly Ser Glu Gln Leu His Ser Lys Pro Ser Val Thr 
        195                 200                 205             


Val Thr His Lys Ser Asn Val Leu Ser Gln Ser Asp Gly Leu Phe Arg 
    210                 215                 220                 


Glu Ser Cys Arg Ser Val Tyr Asp Ala Asn Lys Asp Lys Tyr Ser Gly 
225                 230                 235                 240 


Val Asp His Lys Glu Gln Ile Val Asp Ser Met Val Tyr Arg Met Phe 
                245                 250                 255     


Arg Glu Pro Glu Ile Phe Asp Val Val Val Ala Pro Asn Leu Tyr Gly 
            260                 265                 270         


Asp Ile Leu Ser Asp Gly Ala Ala Ala Leu Val Gly Ser Leu Gly Val 
        275                 280                 285             


Val Pro Ser Ala Asn Val Gly Glu Asn Phe Ala Ile Gly Glu Pro Cys 
    290                 295                 300                 


His Gly Ser Ala Pro Asp Ile Glu Gly Lys Gly Ile Ser Asn Pro Ile 
305                 310                 315                 320 


Ala Thr Ile Arg Ser Thr Ala Leu Met Leu Glu Phe Met Gly Tyr Pro 
                325                 330                 335     


Glu Ala Ala Ala Lys Ile Tyr Glu Ala Val Asp Ala Asn Leu Ser Glu 
            340                 345                 350         


Asp Lys Ile Lys Thr Pro Asp Leu Gly Gly Asn Ser Thr Thr Gln Glu 
        355                 360                 365             


Val Ile Glu Asp Ile Val Arg Arg Phe 
    370                 375         


<210>  68
<211>  377
<212>  PRT
<213>  Lodderomyces elongisporus

<400>  68

Met Leu Ser Thr Ser His Ser Ile Lys Arg Cys Phe Ser Thr Ser Ser 
1               5                   10                  15      


Pro Leu Leu Lys Thr Leu Lys Ile Gly Leu Ile Pro Gly Asp Gly Ile 
            20                  25                  30          


Gly Arg Glu Val Ile Pro Ala Gly Gln Lys Val Leu Glu Ser Leu Pro 
        35                  40                  45              


Ser Lys Phe Asp Leu Gln Phe Glu Phe Val Asn Leu Asp Ala Gly Phe 
    50                  55                  60                  


Glu Leu Phe Lys Lys Thr Gly Thr Ala Leu Pro Asp Gln Thr Val Glu 
65                  70                  75                  80  


Thr Leu Lys Asn Glu Cys Asp Gly Ala Leu Phe Gly Ala Val Ser Ser 
                85                  90                  95      


Pro Thr Thr Lys Val Glu Gly Tyr Ser Ser Pro Ile Val Ala Leu His 
            100                 105                 110         


Lys Lys Leu Gly Leu Tyr Ala Asn Val Arg Pro Val Lys Ser Val Lys 
        115                 120                 125             


Gly Val Gly Arg Pro Val Asp Met Val Ile Val His Glu Asn Thr Glu 
    130                 135                 140                 


Asp Leu Tyr Val Lys Glu Glu Lys Thr Tyr Gln Lys Glu Asp Gly Thr 
145                 150                 155                 160 


Lys Val Ala Glu Ala Ile Lys Arg Ile Ser Glu Thr Ala Ser Lys Arg 
                165                 170                 175     


Ile Ala Lys Met Ala Tyr Asp Ile Ala Leu Gln Arg Gln Ala Ile Arg 
            180                 185                 190         


Asp Ala Ser Pro Gly Ser Glu Gln Leu His Ser Lys Pro Ser Val Thr 
        195                 200                 205             


Val Thr His Lys Ser Asn Val Leu Ser Gln Ser Asp Gly Leu Phe Arg 
    210                 215                 220                 


Glu Ser Cys Arg Ser Val Tyr Asp Ala Asn Lys Asp Lys Tyr Ser Gly 
225                 230                 235                 240 


Val Asp His Lys Glu Gln Ile Val Asp Ser Met Val Tyr Arg Met Phe 
                245                 250                 255     


Arg Glu Pro Glu Ile Phe Asp Val Val Val Ala Pro Asn Leu Tyr Gly 
            260                 265                 270         


Asp Ile Leu Ser Asp Gly Ala Ala Ala Leu Val Gly Ser Leu Gly Val 
        275                 280                 285             


Val Pro Ser Ala Asn Val Gly Glu Asn Phe Ala Ile Gly Glu Pro Cys 
    290                 295                 300                 


His Gly Ser Ala Pro Asp Ile Glu Gly Lys Gly Ile Ser Asn Pro Ile 
305                 310                 315                 320 


Ala Thr Ile Arg Ser Thr Ala Leu Met Leu Glu Phe Met Gly Tyr Pro 
                325                 330                 335     


Glu Ala Ala Ala Lys Ile Tyr Glu Ala Val Asp Ala Asn Leu Ser Glu 
            340                 345                 350         


Asp Lys Ile Lys Thr Pro Asp Leu Gly Gly Asn Ser Thr Thr Gln Glu 
        355                 360                 365             


Val Ile Glu Asp Ile Val Arg Arg Phe 
    370                 375         


<210>  69
<211>  360
<212>  PRT
<213>  Magnaporthe oryzae

<400>  69

Met Ala Thr Ala Arg Ala Leu Arg Ile Gly Leu Ile Ala Gly Asp Gly 
1               5                   10                  15      


Ile Gly Lys Asp Val Val Pro Ala Gly Arg Arg Val Leu Glu Ala Leu 
            20                  25                  30          


Pro Ala Ser Leu Gly Leu Arg Phe Ser Phe Val Asp Leu Gln Ala Gly 
        35                  40                  45              


Phe Gln Thr Phe Glu Glu Thr Gly Ser Ala Leu Pro Asp Arg Thr Val 
    50                  55                  60                  


Glu Thr Leu Lys Gly Glu Cys Asp Gly Ala Leu Phe Gly Ala Val Ser 
65                  70                  75                  80  


Ser Pro Thr Lys Pro Val Lys Gly Tyr Ser Ser Pro Ile Val Gly Leu 
                85                  90                  95      


His Lys Lys Leu Asp Leu Tyr Ala Asn Val Arg Pro Val Lys Thr Val 
            100                 105                 110         


Val Ser Ala Pro Arg Pro Ile Asp Met Val Ile Val His Glu Asn Thr 
        115                 120                 125             


Glu Asp Leu Tyr Val Lys Asp Glu Arg Thr Phe Asp Ala Pro Asp Gly 
    130                 135                 140                 


Ser Gly Pro Val Ala Glu Ala Ile Lys Arg Ile Ser Tyr Arg Ala Ser 
145                 150                 155                 160 


His Arg Ile Ala Ser Met Ala Gly Glu Ile Ala Leu Arg Arg Gln Lys 
                165                 170                 175     


Ile Arg Ala Ala Gly Ala Pro Ser Ile His Ser Ser Pro Leu Val Thr 
            180                 185                 190         


Ile Thr His Lys Ser Asn Val Leu Ser Gln Thr Asp Gly Leu Phe Arg 
        195                 200                 205             


Ser Thr Ala Lys Glu Ala Leu Ala Asp Pro Lys Tyr Ala Gly Ser Val 
    210                 215                 220                 


Ala Val Glu Glu Gln Ile Val Asp Ser Met Val Tyr Lys Leu Phe Arg 
225                 230                 235                 240 


Gln Pro Glu Asp Tyr Asp Val Ile Val Ala Pro Asn Leu Tyr Gly Asp 
                245                 250                 255     


Ile Leu Ser Asp Gly Ala Ala Ala Leu Val Gly Ser Leu Gly Leu Val 
            260                 265                 270         


Pro Ser Ala Asn Val Gly Asp Gly Phe Val Met Gly Glu Pro Cys His 
        275                 280                 285             


Gly Ser Ala Pro Asp Ile Met Gly Lys Asn Ile Ala Asn Pro Ile Ala 
    290                 295                 300                 


Thr Leu Arg Ser Ala Ala Leu Met Leu Glu Phe Leu Asn Glu Glu Glu 
305                 310                 315                 320 


Ala Ala Ala Lys Ile Tyr Ala Ala Val Asp Ala Asn Leu Val Glu Gly 
                325                 330                 335     


Lys Val Leu Ser Pro Asp Leu Gly Gly Lys Ala Thr Thr Asp Gln Val 
            340                 345                 350         


Leu Glu Asp Ile Leu Arg Arg Leu 
        355                 360 


<210>  70
<211>  335
<212>  PRT
<213>  Marinithermus hydrothermalis

<400>  70

Met Gly Gln Thr Tyr Arg Ile Cys Leu Ile Glu Gly Asp Gly Ile Gly 
1               5                   10                  15      


His Glu Val Val Pro Ala Ala Arg Arg Val Leu Glu Ala Thr Gly Leu 
            20                  25                  30          


Lys Phe Glu Phe Thr Glu Ala Glu Ala Gly Trp Glu Thr Phe Glu Lys 
        35                  40                  45              


Tyr Gly Thr Ser Val Pro Glu Glu Thr Val Glu Lys Ile Arg Ala Ala 
    50                  55                  60                  


Asp Ala Thr Leu Phe Gly Ala Ala Thr Ser Pro Thr Arg Lys Val Glu 
65                  70                  75                  80  


Gly Phe Phe Gly Ala Ile Arg Tyr Leu His Lys Arg Leu Asp Leu Phe 
                85                  90                  95      


Ala Asn Val Arg Pro Ala Lys Tyr His Pro Val Pro Gly Ala Ile Gln 
            100                 105                 110         


Gly Thr Asp Leu Val Val Val His Glu Asn Thr Glu Gly Leu Tyr Val 
        115                 120                 125             


Glu Gln Glu Arg Arg Tyr Ala Arg Gly Arg Ile Ala Ile Ala Asp Arg 
    130                 135                 140                 


Val Ile Thr Tyr Asp Ala Ser Tyr Arg Ile Ala Glu Tyr Ala Leu Lys 
145                 150                 155                 160 


Leu Ala Gln Arg Arg Arg Gly Lys Leu Ala Leu Val His Lys Ala Asn 
                165                 170                 175     


Val Leu Pro Leu Ser Asp Gly Leu Phe Leu Glu Ala Ala Tyr Asp Ala 
            180                 185                 190         


Ala Lys His Tyr Pro Asp Val Glu Ile Ser Glu Val Ile Val Asp Ala 
        195                 200                 205             


Cys Ala Met Arg Leu Val Arg Arg Pro Gln Asp Phe Asp Val Leu Val 
    210                 215                 220                 


Met Glu Asn Leu Phe Gly Asp Ile Ile Ser Asp Leu Thr Ala Gly Leu 
225                 230                 235                 240 


Val Gly Gly Leu Gly Ile Ala Pro Ser Gly Asn Ile Gly Glu Glu Ala 
                245                 250                 255     


Ala Ile Phe Glu Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly Lys 
            260                 265                 270         


Gly Ile Ala Asn Pro Thr Ala Thr Ile Leu Ser Ala Ala Met Met Leu 
        275                 280                 285             


Glu His Leu Gly Glu Lys Glu Ala Ala Glu Arg Ile Glu Arg Ala Val 
    290                 295                 300                 


Asp Arg Val Leu Ala Glu Gly Pro Arg Thr Pro Asp Leu Gly Gly Asp 
305                 310                 315                 320 


Ala Thr Thr Glu Ala Phe Thr Asp Ala Val Ile Arg Ala Leu Gly 
                325                 330                 335 


<210>  71
<211>  335
<212>  PRT
<213>  Marinithermus hydrothermalis

<400>  71

Met Gly Gln Thr Tyr Arg Ile Cys Leu Ile Glu Gly Asp Gly Ile Gly 
1               5                   10                  15      


His Glu Val Val Pro Ala Ala Arg Arg Val Leu Glu Ala Thr Gly Leu 
            20                  25                  30          


Lys Phe Glu Phe Thr Glu Ala Glu Ala Gly Trp Glu Thr Phe Glu Lys 
        35                  40                  45              


Tyr Gly Thr Ser Val Pro Glu Glu Thr Val Glu Lys Ile Arg Ala Ala 
    50                  55                  60                  


Asp Ala Thr Leu Phe Gly Ala Ala Thr Ser Pro Thr Arg Lys Val Glu 
65                  70                  75                  80  


Gly Phe Phe Gly Ala Ile Arg Tyr Leu His Lys Arg Leu Asp Leu Phe 
                85                  90                  95      


Ala Asn Val Arg Pro Ala Lys Tyr His Pro Val Pro Gly Ala Ile Gln 
            100                 105                 110         


Gly Thr Asp Leu Val Val Val His Glu Asn Thr Glu Gly Leu Tyr Val 
        115                 120                 125             


Glu Gln Glu Arg Arg Tyr Ala Arg Gly Arg Ile Ala Ile Ala Asp Arg 
    130                 135                 140                 


Val Ile Thr Tyr Asp Ala Ser Tyr Arg Ile Ala Glu Tyr Ala Leu Lys 
145                 150                 155                 160 


Leu Ala Gln Arg Arg Arg Gly Lys Leu Ala Leu Val His Lys Ala Asn 
                165                 170                 175     


Val Leu Pro Leu Ser Asp Gly Leu Phe Leu Glu Ala Ala Tyr Asp Ala 
            180                 185                 190         


Ala Lys His Tyr Pro Asp Val Glu Ile Ser Glu Val Ile Val Asp Ala 
        195                 200                 205             


Cys Ala Met Arg Leu Val Arg Arg Pro Gln Asp Phe Asp Val Leu Val 
    210                 215                 220                 


Met Glu Asn Leu Phe Gly Asp Ile Ile Ser Asp Leu Thr Ala Gly Leu 
225                 230                 235                 240 


Val Gly Gly Leu Gly Ile Ala Pro Ser Gly Asn Ile Gly Glu Glu Ala 
                245                 250                 255     


Ala Ile Phe Glu Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly Lys 
            260                 265                 270         


Gly Ile Ala Asn Pro Thr Ala Thr Ile Leu Ser Ala Ala Met Met Leu 
        275                 280                 285             


Glu His Leu Gly Glu Lys Glu Ala Ala Glu Arg Ile Glu Arg Ala Val 
    290                 295                 300                 


Asp Arg Val Leu Ala Glu Gly Pro Arg Thr Pro Asp Leu Gly Gly Asp 
305                 310                 315                 320 


Ala Thr Thr Glu Ala Phe Thr Asp Ala Val Ile Arg Ala Leu Gly 
                325                 330                 335 


<210>  72
<211>  334
<212>  PRT
<213>  Meiothermus silvanus

<400>  72

Met Ser Arg Val Tyr Arg Ile Cys Leu Ile Glu Gly Asp Gly Ile Gly 
1               5                   10                  15      


His Glu Val Val Pro Ala Ala Arg His Val Leu Glu Ala Thr Gly Leu 
            20                  25                  30          


Lys Cys Glu Phe Val Glu Ala Glu Ala Gly Trp Glu Thr Phe Glu Arg 
        35                  40                  45              


Arg Gly Thr Ser Val Pro Glu Glu Thr Val Glu Ile Val Lys Ser Ala 
    50                  55                  60                  


Asp Ala Thr Leu Phe Gly Ala Ala Thr Ser Pro Thr Lys Lys Val Glu 
65                  70                  75                  80  


Gly Phe Phe Gly Ala Ile Arg Tyr Leu His Arg Arg Leu Asp Leu Phe 
                85                  90                  95      


Ala Asn Val Arg Pro Ala Lys His His Pro Val Lys Gly Ser Thr Pro 
            100                 105                 110         


Gly Thr Asp Leu Val Val Val His Glu Asn Thr Glu Gly Leu Tyr Val 
        115                 120                 125             


Glu Gln Glu Arg Arg Tyr Ala Lys Gly Lys Val Ala Ile Ala Asp Arg 
    130                 135                 140                 


Val Ile Thr Tyr Asp Ala Ser Tyr Arg Ile Val Glu Tyr Ala Leu Lys 
145                 150                 155                 160 


Leu Ala Arg Thr Arg Arg Lys Gln Leu Ala Leu Val His Lys Ala Asn 
                165                 170                 175     


Val Leu Pro Leu Ser Asp Gly Leu Phe Leu Glu Ala Ala Tyr Asp Ala 
            180                 185                 190         


Ala Lys His Tyr Pro Asp Ile Gln Val Ser Glu Val Ile Val Asp Ala 
        195                 200                 205             


Cys Ala Met Arg Leu Val Arg Asn Pro Gln Ser Phe Asp Val Leu Val 
    210                 215                 220                 


Met Glu Asn Leu Phe Gly Asp Ile Leu Ser Asp Leu Thr Ala Gly Leu 
225                 230                 235                 240 


Val Gly Gly Leu Gly Ile Ala Pro Ser Gly Asn Ile Gly Glu Gln Ala 
                245                 250                 255     


Ala Ile Phe Glu Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly Lys 
            260                 265                 270         


Gly Val Ala Asn Pro Thr Ala Ala Ile Leu Ser Ala Ala Ile Met Leu 
        275                 280                 285             


Asp Tyr Leu Gly Glu His Glu Thr Ala Arg Arg Ile Glu Lys Ala Val 
    290                 295                 300                 


Asp Ile Thr Leu Glu Gln Gly Pro Leu Thr Pro Asp Leu Gly Gly Lys 
305                 310                 315                 320 


Ala Gly Thr Leu Glu Phe Ala Lys Ala Val Ala Ala Ala Leu 
                325                 330                 


<210>  73
<211>  334
<212>  PRT
<213>  Meiothermus silvanus

<400>  73

Met Ser Arg Val Tyr Arg Ile Cys Leu Ile Glu Gly Asp Gly Ile Gly 
1               5                   10                  15      


His Glu Val Val Pro Ala Ala Arg His Val Leu Glu Ala Thr Gly Leu 
            20                  25                  30          


Lys Cys Glu Phe Val Glu Ala Glu Ala Gly Trp Glu Thr Phe Glu Arg 
        35                  40                  45              


Arg Gly Thr Ser Val Pro Glu Glu Thr Val Glu Ile Val Lys Ser Ala 
    50                  55                  60                  


Asp Ala Thr Leu Phe Gly Ala Ala Thr Ser Pro Thr Lys Lys Val Glu 
65                  70                  75                  80  


Gly Phe Phe Gly Ala Ile Arg Tyr Leu His Arg Arg Leu Asp Leu Phe 
                85                  90                  95      


Ala Asn Val Arg Pro Ala Lys His His Pro Val Lys Gly Ser Thr Pro 
            100                 105                 110         


Gly Thr Asp Leu Val Val Val His Glu Asn Thr Glu Gly Leu Tyr Val 
        115                 120                 125             


Glu Gln Glu Arg Arg Tyr Ala Lys Gly Lys Val Ala Ile Ala Asp Arg 
    130                 135                 140                 


Val Ile Thr Tyr Asp Ala Ser Tyr Arg Ile Val Glu Tyr Ala Leu Lys 
145                 150                 155                 160 


Leu Ala Arg Thr Arg Arg Lys Gln Leu Ala Leu Val His Lys Ala Asn 
                165                 170                 175     


Val Leu Pro Leu Ser Asp Gly Leu Phe Leu Glu Ala Ala Tyr Asp Ala 
            180                 185                 190         


Ala Lys His Tyr Pro Asp Ile Gln Val Ser Glu Val Ile Val Asp Ala 
        195                 200                 205             


Cys Ala Met Arg Leu Val Arg Asn Pro Gln Ser Phe Asp Val Leu Val 
    210                 215                 220                 


Met Glu Asn Leu Phe Gly Asp Ile Leu Ser Asp Leu Thr Ala Gly Leu 
225                 230                 235                 240 


Val Gly Gly Leu Gly Ile Ala Pro Ser Gly Asn Ile Gly Glu Gln Ala 
                245                 250                 255     


Ala Ile Phe Glu Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly Lys 
            260                 265                 270         


Gly Val Ala Asn Pro Thr Ala Ala Ile Leu Ser Ala Ala Ile Met Leu 
        275                 280                 285             


Asp Tyr Leu Gly Glu His Glu Thr Ala Arg Arg Ile Glu Lys Ala Val 
    290                 295                 300                 


Asp Ile Thr Leu Glu Gln Gly Pro Leu Thr Pro Asp Leu Gly Gly Lys 
305                 310                 315                 320 


Ala Gly Thr Leu Glu Phe Ala Lys Ala Val Ala Ala Ala Leu 
                325                 330                 


<210>  74
<211>  356
<212>  PRT
<213>  Metarhizium acridum

<400>  74

Met Ser Phe Arg Thr Leu Arg Ile Gly Leu Ile Pro Gly Asp Gly Ile 
1               5                   10                  15      


Gly Lys Glu Val Ile Pro Ala Gly Arg Arg Val Leu Glu Ala Leu Pro 
            20                  25                  30          


Ser Tyr Leu Asn Leu Lys Phe Asp Phe Val Asn Leu Lys Ala Gly Phe 
        35                  40                  45              


Glu Ala Phe Glu Gln Thr Gly Thr Ala Leu Pro Glu Ala Thr Val Asp 
    50                  55                  60                  


Val Leu Arg Asn Glu Cys Asp Gly Ala Leu Phe Gly Ala Val Ser Ser 
65                  70                  75                  80  


Pro Thr His Ala Val Lys Gly Tyr Ser Ser Pro Ile Val Ala Leu His 
                85                  90                  95      


Lys Arg Leu Asp Leu Tyr Ala Asn Val Arg Pro Val Lys Thr Val Met 
            100                 105                 110         


Thr Ala Pro Lys Pro Ile Asp Met Val Ile Val His Glu Asn Thr Glu 
        115                 120                 125             


Asp Leu Tyr Val Lys Gln Glu Lys Thr Phe Asp Gly Pro Asp Gly Lys 
    130                 135                 140                 


Val Ala Glu Ala Ile Lys Arg Ile Ser Glu Lys Ala Ser Leu Arg Ile 
145                 150                 155                 160 


Ala Ala Met Ala Gly Asp Ile Ala Ile Arg Arg Asp Arg Ile Arg Gln 
                165                 170                 175     


Ser Gly Ala Ala Ser Ile His Lys Lys Pro Leu Val Thr Ile Thr His 
            180                 185                 190         


Lys Ser Asn Val Leu Ser Gln Thr Asp Gly Leu Phe Arg Glu Ala Ser 
        195                 200                 205             


Lys Arg Ala Leu Ala Asp Pro Arg Phe Ala Thr Val Lys Val Glu Glu 
    210                 215                 220                 


Gln Ile Val Asp Ser Met Val Tyr Lys Leu Phe Arg Gln Pro Glu Asp 
225                 230                 235                 240 


Tyr Asp Val Ile Val Ala Pro Asn Leu Tyr Gly Asp Ile Leu Ser Asp 
                245                 250                 255     


Gly Ala Ala Ala Leu Val Gly Ser Leu Gly Leu Val Pro Ser Ala Asn 
            260                 265                 270         


Val Gly Glu Gly Phe Ala Ile Gly Glu Pro Cys His Gly Ser Ala Pro 
        275                 280                 285             


Asp Ile Met Gly Lys Gly Val Ala Asn Pro Ile Ala Thr Val Arg Ser 
    290                 295                 300                 


Ala Ala Leu Met Leu Glu Phe Leu Asp Glu Pro Ala Ala Ala Ala Lys 
305                 310                 315                 320 


Ile Tyr Ala Ala Val Asp Ala Asn Leu Glu Glu Gly Glu Leu Leu Ser 
                325                 330                 335     


Pro Asp Leu Gly Gly Ser Ala Thr Thr Glu Gln Val Val Glu Asp Ile 
            340                 345                 350         


Leu Lys Lys Leu 
        355     


<210>  75
<211>  356
<212>  PRT
<213>  Metarhizium anisopliae

<400>  75

Met Ser Val Arg Thr Leu Arg Ile Gly Leu Ile Pro Gly Asp Gly Ile 
1               5                   10                  15      


Gly Lys Glu Val Ile Pro Ala Gly Arg Arg Val Leu Glu Ala Leu Pro 
            20                  25                  30          


Ser Tyr Leu Asn Leu Asn Phe Glu Phe Val Asn Leu Lys Ala Gly Phe 
        35                  40                  45              


Glu Ala Phe Glu Gln Thr Gly Thr Ala Leu Pro Glu Ala Thr Val Asp 
    50                  55                  60                  


Val Leu Arg Asn Glu Cys Asp Gly Ala Leu Phe Gly Ala Val Ser Ser 
65                  70                  75                  80  


Pro Thr His Ala Val Lys Gly Tyr Ser Ser Pro Ile Val Ala Leu His 
                85                  90                  95      


Lys Arg Leu Asp Leu Tyr Ala Asn Val Arg Pro Val Lys Thr Val Met 
            100                 105                 110         


Thr Ala Pro Lys Pro Ile Asp Met Val Ile Val His Glu Asn Thr Glu 
        115                 120                 125             


Asp Leu Tyr Val Lys Gln Glu Lys Thr Phe Asp Gly Pro Asp Gly Lys 
    130                 135                 140                 


Val Ala Glu Ala Ile Lys Arg Ile Ser Glu Lys Ala Ser Leu Arg Ile 
145                 150                 155                 160 


Ala Ala Met Ala Gly Glu Ile Ala Val Arg Arg Asp Arg Ile Arg Gln 
                165                 170                 175     


Ser Gly Ala Ala Ser Ile His Lys Lys Pro Leu Val Thr Ile Thr His 
            180                 185                 190         


Lys Ser Asn Val Leu Ser Gln Thr Asp Gly Leu Phe Arg Glu Ala Ser 
        195                 200                 205             


Lys Arg Ala Leu Ala Asp Pro Lys Phe Ala Thr Val Lys Val Glu Glu 
    210                 215                 220                 


Gln Ile Val Asp Ser Met Val Tyr Lys Leu Phe Arg Gln Pro Glu Asp 
225                 230                 235                 240 


Tyr Asp Val Ile Val Ala Pro Asn Leu Tyr Gly Asp Ile Leu Ser Asp 
                245                 250                 255     


Gly Ala Ala Ala Leu Val Gly Ser Leu Gly Leu Val Pro Ser Ala Asn 
            260                 265                 270         


Val Gly Glu Gly Phe Ala Ile Gly Glu Pro Cys His Gly Ser Ala Pro 
        275                 280                 285             


Asp Ile Met Gly Lys Gly Val Ala Asn Pro Ile Ala Thr Leu Arg Ser 
    290                 295                 300                 


Ala Ala Leu Met Leu Glu Phe Leu Asp Glu Pro Ala Ala Ala Ala Lys 
305                 310                 315                 320 


Ile Tyr Ala Ala Val Asp Ala Asn Leu Glu Glu Gly Glu Leu Leu Ser 
                325                 330                 335     


Pro Asp Leu Gly Gly Ser Ala Thr Thr Glu Gln Val Val Glu Asp Ile 
            340                 345                 350         


Leu Lys Lys Leu 
        355     


<210>  76
<211>  347
<212>  PRT
<213>  Methanocaldococcus jannaschii

<400>  76

Met Met Lys Val Cys Val Ile Glu Gly Asp Gly Ile Gly Lys Glu Val 
1               5                   10                  15      


Ile Pro Glu Ala Ile Lys Ile Leu Asn Glu Leu Gly Glu Phe Glu Ile 
            20                  25                  30          


Ile Lys Gly Glu Ala Gly Leu Glu Cys Leu Lys Lys Tyr Gly Asn Ala 
        35                  40                  45              


Leu Pro Glu Asp Thr Ile Glu Lys Ala Lys Glu Ala Asp Ile Ile Leu 
    50                  55                  60                  


Phe Gly Ala Ile Thr Ser Pro Lys Pro Gly Glu Val Lys Asn Tyr Lys 
65                  70                  75                  80  


Ser Pro Ile Ile Thr Leu His Lys Met Phe His Leu Tyr Ala Asn Val 
                85                  90                  95      


Arg Pro Ile Asn Asn Phe Gly Ile Gly Gln Leu Ile Gly Lys Ile Ala 
            100                 105                 110         


Asp Tyr Glu Phe Leu Asn Ala Lys Asn Ile Asp Ile Val Ile Ile His 
        115                 120                 125             


Glu Asn Thr Glu Asp Leu Tyr Val Gly Arg Glu Arg Leu Glu Asn Asp 
    130                 135                 140                 


Thr Ala Ile Ala Glu Arg Val Ile Thr Arg Lys Gly Ser Glu Arg Ile 
145                 150                 155                 160 


Ile Arg Phe Ala Phe Glu Tyr Ala Ile Lys Asn Asn Arg Lys Lys Val 
                165                 170                 175     


Ser Cys Ile His Lys Ala Asn Val Leu Arg Ile Thr Asp Gly Leu Phe 
            180                 185                 190         


Leu Glu Val Phe Asn Glu Ile Lys Lys His Tyr Asn Ile Glu Ala Asp 
        195                 200                 205             


Asp Tyr Leu Val Asp Ser Thr Ala Met Asn Leu Ile Lys His Pro Glu 
    210                 215                 220                 


Lys Phe Asp Val Ile Val Thr Thr Asn Met Phe Gly Asp Ile Leu Ser 
225                 230                 235                 240 


Asp Glu Ala Ser Ala Leu Ile Gly Gly Leu Gly Leu Ala Pro Ser Ala 
                245                 250                 255     


Asn Ile Gly Asp Asp Lys Ala Leu Phe Glu Pro Val His Gly Ser Ala 
            260                 265                 270         


Pro Asp Ile Ala Gly Lys Gly Ile Ala Asn Pro Met Ala Ser Ile Leu 
        275                 280                 285             


Ser Ile Ala Met Leu Phe Asp Tyr Ile Gly Glu Lys Glu Lys Gly Asp 
    290                 295                 300                 


Leu Ile Arg Glu Ala Val Lys Tyr Cys Leu Ile Asn Lys Lys Val Thr 
305                 310                 315                 320 


Pro Asp Leu Gly Gly Asp Leu Lys Thr Lys Asp Val Gly Asp Glu Ile 
                325                 330                 335     


Leu Asn Tyr Ile Arg Lys Lys Leu Lys Gly Tyr 
            340                 345         


<210>  77
<211>  347
<212>  PRT
<213>  Methanocaldococcus jannaschii

<400>  77

Met Met Lys Val Cys Val Ile Glu Gly Asp Gly Ile Gly Lys Glu Val 
1               5                   10                  15      


Ile Pro Glu Ala Ile Lys Ile Leu Asn Glu Leu Gly Glu Phe Glu Ile 
            20                  25                  30          


Ile Lys Gly Glu Ala Gly Leu Glu Cys Leu Lys Lys Tyr Gly Asn Ala 
        35                  40                  45              


Leu Pro Glu Asp Thr Ile Glu Lys Ala Lys Glu Ala Asp Ile Ile Leu 
    50                  55                  60                  


Phe Gly Ala Ile Thr Ser Pro Lys Pro Gly Glu Val Lys Asn Tyr Lys 
65                  70                  75                  80  


Ser Pro Ile Ile Thr Leu His Lys Met Phe His Leu Tyr Ala Asn Val 
                85                  90                  95      


Arg Pro Ile Asn Asn Phe Gly Ile Gly Gln Leu Ile Gly Lys Ile Ala 
            100                 105                 110         


Asp Tyr Glu Phe Leu Asn Ala Lys Asn Ile Asp Ile Val Ile Ile His 
        115                 120                 125             


Glu Asn Thr Glu Asp Leu Tyr Val Gly Arg Glu Arg Leu Glu Asn Asp 
    130                 135                 140                 


Thr Ala Ile Ala Glu Arg Val Ile Thr Arg Lys Gly Ser Glu Arg Ile 
145                 150                 155                 160 


Ile Arg Phe Ala Phe Glu Tyr Ala Ile Lys Asn Asn Arg Lys Lys Val 
                165                 170                 175     


Ser Cys Ile His Lys Ala Asn Val Leu Arg Ile Thr Asp Gly Leu Phe 
            180                 185                 190         


Leu Glu Val Phe Asn Glu Ile Lys Lys His Tyr Asn Ile Glu Ala Asp 
        195                 200                 205             


Asp Tyr Leu Val Asp Ser Thr Ala Met Asn Leu Ile Lys His Pro Glu 
    210                 215                 220                 


Lys Phe Asp Val Ile Val Thr Thr Asn Met Phe Gly Asp Ile Leu Ser 
225                 230                 235                 240 


Asp Glu Ala Ser Ala Leu Ile Gly Gly Leu Gly Leu Ala Pro Ser Ala 
                245                 250                 255     


Asn Ile Gly Asp Asp Lys Ala Leu Phe Glu Pro Val His Gly Ser Ala 
            260                 265                 270         


Pro Asp Ile Ala Gly Lys Gly Ile Ala Asn Pro Met Ala Ser Ile Leu 
        275                 280                 285             


Ser Ile Ala Met Leu Phe Asp Tyr Ile Gly Glu Lys Glu Lys Gly Asp 
    290                 295                 300                 


Leu Ile Arg Glu Ala Val Lys Tyr Cys Leu Ile Asn Lys Lys Val Thr 
305                 310                 315                 320 


Pro Asp Leu Gly Gly Asp Leu Lys Thr Lys Asp Val Gly Asp Glu Ile 
                325                 330                 335     


Leu Asn Tyr Ile Arg Lys Lys Leu Lys Gly Tyr 
            340                 345         


<210>  78
<211>  331
<212>  PRT
<213>  Methanohalophilus mahii

<400>  78

Met Lys Leu Ala Val Ile Glu Gly Asp Gly Val Gly Lys Glu Val Ile 
1               5                   10                  15      


Pro Ala Ala Leu Arg Val Leu Asp Cys Phe Asp Leu Pro Leu Glu Ile 
            20                  25                  30          


Ile Pro Leu Glu Leu Gly Tyr Gly Lys Trp Glu Lys Thr Gly Gln Ala 
        35                  40                  45              


Ile Thr Asp Ala Asp Leu Glu Ile Leu Lys Asn Cys Asp Cys Ile Leu 
    50                  55                  60                  


Phe Gly Ala Val Thr Thr Pro Ala Asp Pro Asn Tyr Lys Ser Val Leu 
65                  70                  75                  80  


Leu Thr Ile His Arg Glu Leu Asp Leu Tyr Ala Asn Ile Arg Pro Leu 
                85                  90                  95      


Lys Pro Ile Lys Gly Ile Glu Gly Ala Thr Gly Asn Thr Asp Phe Asp 
            100                 105                 110         


Ile Leu Val Val His Glu Asn Thr Glu Gly Leu Tyr Ser Ser Ile Glu 
        115                 120                 125             


Glu Val Gly Glu Asn Glu Ala Trp Ser Lys Arg Ile Ile Thr Arg Arg 
    130                 135                 140                 


Ala Ser Glu Arg Ile Ala Gln Ile Ala Cys Glu Tyr Ala Ala Lys Arg 
145                 150                 155                 160 


His Asn His Leu Thr Ile Val His Lys Ser Asn Val Ile Lys Ala Asp 
                165                 170                 175     


Ser Leu Phe Leu Asn Thr Cys Arg Asn Val Ala Gln Ala His Asn Val 
            180                 185                 190         


Ile His Asp Thr Met Leu Val Asp Ala Met Ala Tyr Asp Met Val Arg 
        195                 200                 205             


Ser Pro Glu Lys Tyr Asp Val Val Val Ala Pro Asn Leu Tyr Gly Asp 
    210                 215                 220                 


Ile Leu Ser Asp Leu Gly Gly Ala Leu Val Gly Ser Leu Gly Leu Leu 
225                 230                 235                 240 


Pro Ser Ala Asn Ile Gly Glu Lys Gln Ala Phe Phe Glu Pro Val His 
                245                 250                 255     


Gly Ser Ala Pro Asp Ile Ala Gly Lys Gly Ile Ala Asn Pro Ile Ala 
            260                 265                 270         


Ala Val Leu Ser Val Ala Met Leu Leu Asp Trp Leu Asp Arg Pro Glu 
        275                 280                 285             


Gln Ala Arg Ile Val Arg Glu Ala Val Glu Ala Ser Ile Asn Glu Asp 
    290                 295                 300                 


Ile Lys Thr Ala Asp Leu Gly Gly Asn Phe Thr Thr Glu Gln Val Thr 
305                 310                 315                 320 


Gly Phe Leu Val Arg Tyr Val Gln Ser His Ser 
                325                 330     


<210>  79
<211>  331
<212>  PRT
<213>  Methanohalophilus mahii

<400>  79

Met Lys Leu Ala Val Ile Glu Gly Asp Gly Val Gly Lys Glu Val Ile 
1               5                   10                  15      


Pro Ala Ala Leu Arg Val Leu Asp Cys Phe Asp Leu Pro Leu Glu Ile 
            20                  25                  30          


Ile Pro Leu Glu Leu Gly Tyr Gly Lys Trp Glu Lys Thr Gly Gln Ala 
        35                  40                  45              


Ile Thr Asp Ala Asp Leu Glu Ile Leu Lys Asn Cys Asp Cys Ile Leu 
    50                  55                  60                  


Phe Gly Ala Val Thr Thr Pro Ala Asp Pro Asn Tyr Lys Ser Val Leu 
65                  70                  75                  80  


Leu Thr Ile His Arg Glu Leu Asp Leu Tyr Ala Asn Ile Arg Pro Leu 
                85                  90                  95      


Lys Pro Ile Lys Gly Ile Glu Gly Ala Thr Gly Asn Thr Asp Phe Asp 
            100                 105                 110         


Ile Leu Val Val His Glu Asn Thr Glu Gly Leu Tyr Ser Ser Ile Glu 
        115                 120                 125             


Glu Val Gly Glu Asn Glu Ala Trp Ser Lys Arg Ile Ile Thr Arg Arg 
    130                 135                 140                 


Ala Ser Glu Arg Ile Ala Gln Ile Ala Cys Glu Tyr Ala Ala Lys Arg 
145                 150                 155                 160 


His Asn His Leu Thr Ile Val His Lys Ser Asn Val Ile Lys Ala Asp 
                165                 170                 175     


Ser Leu Phe Leu Asn Thr Cys Arg Asn Val Ala Gln Ala His Asn Val 
            180                 185                 190         


Ile His Asp Thr Met Leu Val Asp Ala Met Ala Tyr Asp Met Val Arg 
        195                 200                 205             


Ser Pro Glu Lys Tyr Asp Val Val Val Ala Pro Asn Leu Tyr Gly Asp 
    210                 215                 220                 


Ile Leu Ser Asp Leu Gly Gly Ala Leu Val Gly Ser Leu Gly Leu Leu 
225                 230                 235                 240 


Pro Ser Ala Asn Ile Gly Glu Lys Gln Ala Phe Phe Glu Pro Val His 
                245                 250                 255     


Gly Ser Ala Pro Asp Ile Ala Gly Lys Gly Ile Ala Asn Pro Ile Ala 
            260                 265                 270         


Ala Val Leu Ser Val Ala Met Leu Leu Asp Trp Leu Asp Arg Pro Glu 
        275                 280                 285             


Gln Ala Arg Ile Val Arg Glu Ala Val Glu Ala Ser Ile Asn Glu Asp 
    290                 295                 300                 


Ile Lys Thr Ala Asp Leu Gly Gly Asn Phe Thr Thr Glu Gln Val Thr 
305                 310                 315                 320 


Gly Phe Leu Val Arg Tyr Val Gln Ser His Ser 
                325                 330     


<210>  80
<211>  317
<212>  PRT
<213>  Methanosaeta concilii

<400>  80

Met Ile Ala Gly Asp Gly Ile Gly Pro Glu Val Val Glu Ser Ala Leu 
1               5                   10                  15      


Glu Val Leu Arg Ala Ala Gly Ala Ser Leu Asp Leu Val His Phe Glu 
            20                  25                  30          


Ile Gly Leu Gly Arg Trp Lys Arg Thr Gly Glu Ala Met Asp Glu Asp 
        35                  40                  45              


Asp Leu Glu Glu Ile Ser Gly Cys Asp Cys Ile Leu Leu Gly Ala Ile 
    50                  55                  60                  


Thr Thr Pro Pro Asp Pro Asn Tyr Arg Ser Val Leu Leu Arg Leu His 
65                  70                  75                  80  


Arg Ala Leu Asp Leu Tyr Ala Asn Ile Arg Pro Phe Gln Ser His Asp 
                85                  90                  95      


Leu Asp Phe Ile Ile Val His Glu Asn Thr Glu Gly Leu Tyr Ser Gly 
            100                 105                 110         


Val Glu Glu Val Gly Val Glu Glu Ser Arg Thr Leu Arg Val Ile Thr 
        115                 120                 125             


Arg Arg Gly Ser Glu Arg Ile Ala Glu Ala Ala Cys Asp Leu Ala Ala 
    130                 135                 140                 


Arg Arg Arg Arg Leu Thr Ile Ile His Lys Ser Asn Val Leu Arg Ser 
145                 150                 155                 160 


Asp Arg Leu Phe Leu Gln Thr Cys Arg Glu Val Ala Glu Arg Arg Gly 
                165                 170                 175     


Ile Leu Tyr Glu Asp Met Leu Val Asp Ala Ala Ala Tyr Asn Leu Val 
            180                 185                 190         


Thr Asn Pro Gln Arg Phe Asp Val Leu Val Thr Thr Asn Leu Phe Gly 
        195                 200                 205             


Asp Ile Leu Ser Asp Glu Ala Ala Gly Val Ile Gly Ser Leu Gly Leu 
    210                 215                 220                 


Cys Ala Ser Ala Asn Leu Gly Lys Ser Arg Ala Leu Phe Glu Pro Ile 
225                 230                 235                 240 


His Gly Ser Ala Pro Asp Ile Ala Gly Lys Gly Ile Ala Asn Pro Val 
                245                 250                 255     


Gly Ala Ile Arg Ser Ala Ala Met Met Met Arg Trp Leu Gly Glu Leu 
            260                 265                 270         


Glu Ala Ala Gly Arg Met Glu Glu Ala Val Lys Lys Ala Leu Ser Ala 
        275                 280                 285             


Gly Val Arg Thr Pro Asp Leu Gly Gly Arg Cys Ser Thr Ser Glu Val 
    290                 295                 300                 


Thr Gly Ala Val Thr Gly Tyr Leu Met Ala Glu Glu Ser 
305                 310                 315         


<210>  81
<211>  317
<212>  PRT
<213>  Methanosaeta concilii

<400>  81

Met Ile Ala Gly Asp Gly Ile Gly Pro Glu Val Val Glu Ser Ala Leu 
1               5                   10                  15      


Glu Val Leu Arg Ala Ala Gly Ala Ser Leu Asp Leu Val His Phe Glu 
            20                  25                  30          


Ile Gly Leu Gly Arg Trp Lys Arg Thr Gly Glu Ala Met Asp Glu Asp 
        35                  40                  45              


Asp Leu Glu Glu Ile Ser Gly Cys Asp Cys Ile Leu Leu Gly Ala Ile 
    50                  55                  60                  


Thr Thr Pro Pro Asp Pro Asn Tyr Arg Ser Val Leu Leu Arg Leu His 
65                  70                  75                  80  


Arg Ala Leu Asp Leu Tyr Ala Asn Ile Arg Pro Phe Gln Ser His Asp 
                85                  90                  95      


Leu Asp Phe Ile Ile Val His Glu Asn Thr Glu Gly Leu Tyr Ser Gly 
            100                 105                 110         


Val Glu Glu Val Gly Val Glu Glu Ser Arg Thr Leu Arg Val Ile Thr 
        115                 120                 125             


Arg Arg Gly Ser Glu Arg Ile Ala Glu Ala Ala Cys Asp Leu Ala Ala 
    130                 135                 140                 


Arg Arg Arg Arg Leu Thr Ile Ile His Lys Ser Asn Val Leu Arg Ser 
145                 150                 155                 160 


Asp Arg Leu Phe Leu Gln Thr Cys Arg Glu Val Ala Glu Arg Arg Gly 
                165                 170                 175     


Ile Leu Tyr Glu Asp Met Leu Val Asp Ala Ala Ala Tyr Asn Leu Val 
            180                 185                 190         


Thr Asn Pro Gln Arg Phe Asp Val Leu Val Thr Thr Asn Leu Phe Gly 
        195                 200                 205             


Asp Ile Leu Ser Asp Glu Ala Ala Gly Val Ile Gly Ser Leu Gly Leu 
    210                 215                 220                 


Cys Ala Ser Ala Asn Leu Gly Lys Ser Arg Ala Leu Phe Glu Pro Ile 
225                 230                 235                 240 


His Gly Ser Ala Pro Asp Ile Ala Gly Lys Gly Ile Ala Asn Pro Val 
                245                 250                 255     


Gly Ala Ile Arg Ser Ala Ala Met Met Met Arg Trp Leu Gly Glu Leu 
            260                 265                 270         


Glu Ala Ala Gly Arg Met Glu Glu Ala Val Lys Lys Ala Leu Ser Ala 
        275                 280                 285             


Gly Val Arg Thr Pro Asp Leu Gly Gly Arg Cys Ser Thr Ser Glu Val 
    290                 295                 300                 


Thr Gly Ala Val Thr Gly Tyr Leu Met Ala Glu Glu Ser 
305                 310                 315         


<210>  82
<211>  357
<212>  PRT
<213>  Neurospora crassa

<400>  82

Met Ala Ala Arg Thr Leu Lys Ile Gly Leu Ile Pro Gly Asp Gly Ile 
1               5                   10                  15      


Gly Lys Glu Val Ile Pro Ala Gly Arg Arg Ile Leu Glu Ala Leu Pro 
            20                  25                  30          


Ala Ser Leu Gly Leu Lys Phe Glu Phe Ile Asp Leu Lys Ala Gly Trp 
        35                  40                  45              


Glu Thr Phe Glu Gln Thr Gly Asn Ala Leu Pro Glu Glu Thr Val Ser 
    50                  55                  60                  


Ile Leu Lys Ser Glu Cys Asp Gly Ala Leu Phe Gly Ala Val Ser Ser 
65                  70                  75                  80  


Pro Thr Lys Ala Val Lys Gly Tyr Ser Ser Pro Ile Val Ala Leu His 
                85                  90                  95      


Lys Lys Leu Asp Leu Tyr Ala Asn Val Arg Pro Val Lys Ser Val Arg 
            100                 105                 110         


Gly Pro Gly Val Lys Pro Ile Asp Met Val Ile Val His Glu Asn Thr 
        115                 120                 125             


Glu Asp Leu Tyr Val Lys Glu Glu Lys Thr Tyr Asp Thr Pro Glu Gly 
    130                 135                 140                 


Lys Val Ala Glu Ala Ile Lys Arg Ile Ser Gln Arg Ala Ser Ser Arg 
145                 150                 155                 160 


Ile Ala Thr Ile Ala Gly Glu Ile Ala Leu Arg Arg Gln Lys Ile Arg 
                165                 170                 175     


Glu Gly Gly Ser Pro Ser Ile His Lys Gly Pro Leu Val Thr Val Thr 
            180                 185                 190         


His Lys Ser Asn Val Leu Ser Gln Thr Asp Gly Leu Phe Arg Ser Thr 
        195                 200                 205             


Ala Arg Glu Ala Leu Ala Ala Gly Arg Phe Thr Ser Val Ala Val Glu 
    210                 215                 220                 


Glu Gln Ile Val Asp Ser Met Val Tyr Lys Leu Phe Arg Gln Pro Glu 
225                 230                 235                 240 


Ala Tyr Asp Val Ile Val Ala Pro Asn Leu Tyr Gly Asp Ile Leu Ser 
                245                 250                 255     


Asp Gly Ala Ala Ala Leu Val Gly Ser Leu Gly Leu Val Pro Ser Ala 
            260                 265                 270         


Asn Val Gly Glu Gly Phe Ala Ile Gly Glu Pro Cys His Gly Ser Ala 
        275                 280                 285             


Pro Asp Ile Gln Gly Gln Asn Ile Ala Asn Pro Ile Ala Thr Leu Arg 
    290                 295                 300                 


Ser Ala Ala Leu Met Leu Glu Phe Leu Asn Glu Glu Glu Ala Ala Ala 
305                 310                 315                 320 


Lys Ile Tyr Ala Ala Val Asp Ala Asn Leu Glu Glu Gly Lys Leu Leu 
                325                 330                 335     


Ser Pro Asp Leu Gly Gly Lys Ala Lys Thr Glu Glu Val Val Gln Asp 
            340                 345                 350         


Ile Leu Arg Arg Leu 
        355         


<210>  83
<211>  357
<212>  PRT
<213>  Neurospora crassa

<400>  83

Met Ala Ala Arg Thr Leu Lys Ile Gly Leu Ile Pro Gly Asp Gly Ile 
1               5                   10                  15      


Gly Lys Glu Val Ile Pro Ala Gly Arg Arg Ile Leu Glu Ala Leu Pro 
            20                  25                  30          


Ala Ser Leu Gly Leu Lys Phe Glu Phe Ile Asp Leu Lys Ala Gly Trp 
        35                  40                  45              


Glu Thr Phe Glu Gln Thr Gly Asn Ala Leu Pro Glu Glu Thr Val Ser 
    50                  55                  60                  


Ile Leu Lys Ser Glu Cys Asp Gly Ala Leu Phe Gly Ala Val Ser Ser 
65                  70                  75                  80  


Pro Thr Lys Ala Val Lys Gly Tyr Ser Ser Pro Ile Val Ala Leu His 
                85                  90                  95      


Lys Lys Leu Asp Leu Tyr Ala Asn Val Arg Pro Val Lys Ser Val Arg 
            100                 105                 110         


Gly Pro Gly Val Lys Pro Ile Asp Met Val Ile Val His Glu Asn Thr 
        115                 120                 125             


Glu Asp Leu Tyr Val Lys Glu Glu Lys Thr Tyr Asp Thr Pro Glu Gly 
    130                 135                 140                 


Lys Val Ala Glu Ala Ile Lys Arg Ile Ser Gln Arg Ala Ser Ser Arg 
145                 150                 155                 160 


Ile Ala Thr Ile Ala Gly Glu Ile Ala Leu Arg Arg Gln Lys Ile Arg 
                165                 170                 175     


Glu Gly Gly Ser Pro Ser Ile His Lys Gly Pro Leu Val Thr Val Thr 
            180                 185                 190         


His Lys Ser Asn Val Leu Ser Gln Thr Asp Gly Leu Phe Arg Ser Thr 
        195                 200                 205             


Ala Arg Glu Ala Leu Ala Ala Gly Arg Phe Thr Ser Val Ala Val Glu 
    210                 215                 220                 


Glu Gln Ile Val Asp Ser Met Val Tyr Lys Leu Phe Arg Gln Pro Glu 
225                 230                 235                 240 


Ala Tyr Asp Val Ile Val Ala Pro Asn Leu Tyr Gly Asp Ile Leu Ser 
                245                 250                 255     


Asp Gly Ala Ala Ala Leu Val Gly Ser Leu Gly Leu Val Pro Ser Ala 
            260                 265                 270         


Asn Val Gly Glu Gly Phe Ala Ile Gly Glu Pro Cys His Gly Ser Ala 
        275                 280                 285             


Pro Asp Ile Gln Gly Gln Asn Ile Ala Asn Pro Ile Ala Thr Leu Arg 
    290                 295                 300                 


Ser Ala Ala Leu Met Leu Glu Phe Leu Asn Glu Glu Glu Ala Ala Ala 
305                 310                 315                 320 


Lys Ile Tyr Ala Ala Val Asp Ala Asn Leu Glu Glu Gly Lys Leu Leu 
                325                 330                 335     


Ser Pro Asp Leu Gly Gly Lys Ala Lys Thr Glu Glu Val Val Gln Asp 
            340                 345                 350         


Ile Leu Arg Arg Leu 
        355         


<210>  84
<211>  357
<212>  PRT
<213>  Neurospora tetrasperma

<400>  84

Met Ala Ala Arg Thr Leu Lys Ile Gly Leu Ile Pro Gly Asp Gly Ile 
1               5                   10                  15      


Gly Lys Glu Val Ile Pro Ala Gly Arg Arg Ile Leu Glu Ala Leu Pro 
            20                  25                  30          


Ala Ser Leu Gly Leu Lys Phe Glu Phe Ile Asp Leu Lys Ala Gly Trp 
        35                  40                  45              


Glu Thr Phe Glu Gln Thr Gly Asn Ala Leu Pro Glu Glu Thr Val Ser 
    50                  55                  60                  


Ile Leu Lys Ser Glu Cys Asp Gly Ala Leu Phe Gly Ala Val Ser Ser 
65                  70                  75                  80  


Pro Thr Lys Ala Val Lys Gly Tyr Ser Ser Pro Ile Val Ala Leu His 
                85                  90                  95      


Lys Lys Leu Asp Leu Tyr Ala Asn Val Arg Pro Val Lys Ser Val Arg 
            100                 105                 110         


Gly Pro Gly Val Lys Pro Ile Asp Met Val Ile Val His Glu Asn Thr 
        115                 120                 125             


Glu Asp Leu Tyr Val Lys Glu Glu Lys Thr Tyr Asp Thr Pro Glu Gly 
    130                 135                 140                 


Lys Val Ala Glu Ala Ile Lys Arg Ile Ser Gln Arg Ala Ser Ser Arg 
145                 150                 155                 160 


Ile Ala Thr Ile Ala Gly Glu Ile Ala Leu Arg Arg Gln Lys Ile Arg 
                165                 170                 175     


Glu Gly Gly Ser Pro Ser Ile His Lys Gly Pro Leu Val Thr Val Thr 
            180                 185                 190         


His Lys Ser Asn Val Leu Ser Gln Thr Asp Gly Leu Phe Arg Ser Thr 
        195                 200                 205             


Ala Arg Glu Ala Leu Ala Ala Gly Arg Phe Thr Ser Val Ala Val Glu 
    210                 215                 220                 


Glu Gln Ile Val Asp Ser Met Val Tyr Lys Leu Phe Arg Gln Pro Glu 
225                 230                 235                 240 


Ala Tyr Asp Val Ile Val Ala Pro Asn Leu Tyr Gly Asp Ile Leu Ser 
                245                 250                 255     


Asp Gly Ala Ala Ala Leu Val Gly Ser Leu Gly Leu Val Pro Ser Ala 
            260                 265                 270         


Asn Val Gly Glu Gly Phe Ala Ile Gly Glu Pro Cys His Gly Ser Ala 
        275                 280                 285             


Pro Asp Ile Gln Gly Gln Asn Ile Ala Asn Pro Ile Ala Thr Leu Arg 
    290                 295                 300                 


Ser Ala Ala Leu Met Leu Glu Phe Leu Asn Glu Glu Glu Ala Ala Ala 
305                 310                 315                 320 


Lys Ile Tyr Ala Ala Val Asp Ala Asn Leu Glu Glu Gly Lys Leu Leu 
                325                 330                 335     


Ser Pro Asp Leu Gly Gly Lys Ala Lys Thr Glu Glu Val Val Gln Asp 
            340                 345                 350         


Ile Leu Arg Arg Leu 
        355         


<210>  85
<211>  341
<212>  PRT
<213>  Oceanithermus profundus

<400>  85

Met Glu Asn Arg Val Tyr Lys Ile Thr Leu Ile Glu Gly Asp Gly Ile 
1               5                   10                  15      


Gly His Glu Val Ile Pro Ala Ala Arg Thr Val Leu Glu Ala Thr Gly 
            20                  25                  30          


Leu Ser Phe Val Phe Asp Glu Ala Glu Ala Gly Trp Glu Thr Phe Glu 
        35                  40                  45              


Arg Ile Gly Thr Ser Val Pro Glu Glu Thr Val Glu Lys Ile Glu Arg 
    50                  55                  60                  


Ser Asp Ala Thr Leu Phe Gly Ala Ala Thr Ser Pro Thr Lys Lys Val 
65                  70                  75                  80  


Glu Gly Phe Phe Gly Ala Ile Arg Tyr Leu His Arg Arg Leu Asp Leu 
                85                  90                  95      


Phe Ala Asn Val Arg Pro Ala Lys Tyr His Pro Val Pro Gly Ala Thr 
            100                 105                 110         


Pro Gly Thr Asp Leu Ile Val Val His Glu Asn Thr Glu Gly Leu Tyr 
        115                 120                 125             


Val Glu Gln Glu Arg Arg Tyr Ala Arg Gly Arg Val Ala Ile Ala Asp 
    130                 135                 140                 


Arg Val Ile Thr Tyr Asp Ala Ser Tyr Arg Ile Val Glu Phe Ala Leu 
145                 150                 155                 160 


Glu Leu Ala Glu Arg Arg Arg Gly Gln Leu Ala Leu Val His Lys Ala 
                165                 170                 175     


Asn Val Leu Pro Leu Ser Asp Gly Leu Phe Leu Glu Ala Ala Tyr Asp 
            180                 185                 190         


Ala Ala Lys Arg His Pro Thr Val Glu Ile Glu Glu Val Ile Val Asp 
        195                 200                 205             


Ala Cys Ala Met Arg Leu Val Arg Asp Pro Ser Gln Phe Asp Val Leu 
    210                 215                 220                 


Val Met Glu Asn Leu Phe Gly Asp Ile Ile Ser Asp Leu Thr Ala Gly 
225                 230                 235                 240 


Leu Val Gly Gly Leu Gly Ile Ala Pro Ser Gly Asn Ile Gly Glu Arg 
                245                 250                 255     


Ala Ala Ile Phe Glu Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly 
            260                 265                 270         


Lys Gly Ile Ala Asn Pro Thr Ala Thr Ile Leu Ser Ala Ala Met Met 
        275                 280                 285             


Leu Asp His Leu Gly Glu Ser Arg Val Ala Arg Val Ile Glu Glu Ala 
    290                 295                 300                 


Val Asp Arg Val Leu Glu Ser Gly Pro Arg Thr Pro Asp Leu Gly Gly 
305                 310                 315                 320 


Arg Ala Thr Thr Gln Glu Phe Ala Glu Ala Val Ala Ala Lys Val Gln 
                325                 330                 335     


Glu Leu Leu Ser Ala 
            340     


<210>  86
<211>  341
<212>  PRT
<213>  Oceanithermus profundus

<400>  86

Met Glu Asn Arg Val Tyr Lys Ile Thr Leu Ile Glu Gly Asp Gly Ile 
1               5                   10                  15      


Gly His Glu Val Ile Pro Ala Ala Arg Thr Val Leu Glu Ala Thr Gly 
            20                  25                  30          


Leu Ser Phe Val Phe Asp Glu Ala Glu Ala Gly Trp Glu Thr Phe Glu 
        35                  40                  45              


Arg Ile Gly Thr Ser Val Pro Glu Glu Thr Val Glu Lys Ile Glu Arg 
    50                  55                  60                  


Ser Asp Ala Thr Leu Phe Gly Ala Ala Thr Ser Pro Thr Lys Lys Val 
65                  70                  75                  80  


Glu Gly Phe Phe Gly Ala Ile Arg Tyr Leu His Arg Arg Leu Asp Leu 
                85                  90                  95      


Phe Ala Asn Val Arg Pro Ala Lys Tyr His Pro Val Pro Gly Ala Thr 
            100                 105                 110         


Pro Gly Thr Asp Leu Ile Val Val His Glu Asn Thr Glu Gly Leu Tyr 
        115                 120                 125             


Val Glu Gln Glu Arg Arg Tyr Ala Arg Gly Arg Val Ala Ile Ala Asp 
    130                 135                 140                 


Arg Val Ile Thr Tyr Asp Ala Ser Tyr Arg Ile Val Glu Phe Ala Leu 
145                 150                 155                 160 


Glu Leu Ala Glu Arg Arg Arg Gly Gln Leu Ala Leu Val His Lys Ala 
                165                 170                 175     


Asn Val Leu Pro Leu Ser Asp Gly Leu Phe Leu Glu Ala Ala Tyr Asp 
            180                 185                 190         


Ala Ala Lys Arg His Pro Thr Val Glu Ile Glu Glu Val Ile Val Asp 
        195                 200                 205             


Ala Cys Ala Met Arg Leu Val Arg Asp Pro Ser Gln Phe Asp Val Leu 
    210                 215                 220                 


Val Met Glu Asn Leu Phe Gly Asp Ile Ile Ser Asp Leu Thr Ala Gly 
225                 230                 235                 240 


Leu Val Gly Gly Leu Gly Ile Ala Pro Ser Gly Asn Ile Gly Glu Arg 
                245                 250                 255     


Ala Ala Ile Phe Glu Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly 
            260                 265                 270         


Lys Gly Ile Ala Asn Pro Thr Ala Thr Ile Leu Ser Ala Ala Met Met 
        275                 280                 285             


Leu Asp His Leu Gly Glu Ser Arg Val Ala Arg Val Ile Glu Glu Ala 
    290                 295                 300                 


Val Asp Arg Val Leu Glu Ser Gly Pro Arg Thr Pro Asp Leu Gly Gly 
305                 310                 315                 320 


Arg Ala Thr Thr Gln Glu Phe Ala Glu Ala Val Ala Ala Lys Val Gln 
                325                 330                 335     


Glu Leu Leu Ser Ala 
            340     


<210>  87
<211>  357
<212>  PRT
<213>  Ogataea parapolymorpha

<400>  87

Met Ser Pro Ala Asn Ile Ala Gly Leu Ile Pro Gly Asp Gly Ile Gly 
1               5                   10                  15      


Arg Glu Val Ile Pro Ala Gly Lys Gln Val Leu Glu Ala Leu Pro Ser 
            20                  25                  30          


Asp Leu Gly Leu Lys Phe Glu Phe Thr Glu Leu Lys Ala Gly Phe Glu 
        35                  40                  45              


Leu Phe Lys Gln Thr Gly Thr Ala Leu Pro Asp Glu Thr Val Glu Val 
    50                  55                  60                  


Leu Gln Lys Ser Cys Asp Gly Ala Leu Phe Gly Ala Val Ser Ser Pro 
65                  70                  75                  80  


Thr Thr Lys Val Glu Gly Tyr Ser Ser Pro Ile Val Ala Leu His Lys 
                85                  90                  95      


Lys Leu Gly Leu Tyr Ala Asn Val Arg Pro Val Lys Ser Val Glu Gly 
            100                 105                 110         


Ile Gly Arg Pro Val Asp Met Val Ile Val His Glu Asn Thr Glu Asp 
        115                 120                 125             


Leu Tyr Ile Lys Glu Glu Lys Leu Tyr Glu Lys Asp Gly Gln Lys Val 
    130                 135                 140                 


Ala Glu Ala Ile Lys Arg Ile Thr Glu Arg Ala Thr Thr Lys Ile Gly 
145                 150                 155                 160 


Ala Ile Ala Leu Glu Ile Ala Leu Gln Arg Gln Ala Ile Arg Glu Leu 
                165                 170                 175     


Gly Gly Ala Ser Leu His Ser Gln Pro Thr Leu Thr Val Thr His Lys 
            180                 185                 190         


Ser Asn Val Leu Ser Val Ser Asp Gly Leu Phe Arg Glu Thr Val Arg 
        195                 200                 205             


Lys Leu Tyr Asp Ser Asn Pro Ala Lys Tyr Ser Gly Val Gln Tyr Lys 
    210                 215                 220                 


Glu Gln Ile Val Asp Ser Met Val Tyr Arg Met Phe Arg Glu Pro Glu 
225                 230                 235                 240 


Ile Phe Asp Val Val Val Ala Pro Asn Leu Tyr Gly Asp Ile Leu Ser 
                245                 250                 255     


Asp Gly Ala Ala Ala Leu Val Gly Ser Leu Gly Val Val Pro Ser Ala 
            260                 265                 270         


Asn Val Gly Asp Asn Phe Ala Ile Gly Glu Pro Cys His Gly Ser Ala 
        275                 280                 285             


Pro Asp Ile Glu Gly Lys Gly Ile Ala Asn Pro Ile Ala Thr Ile Arg 
    290                 295                 300                 


Ser Thr Ala Leu Met Leu Glu Phe Met Gly His Pro Glu Ala Ala Ser 
305                 310                 315                 320 


Lys Ile Tyr Ala Ala Val Asp Ala Asn Leu Lys Glu Asp Val Ile Lys 
                325                 330                 335     


Thr Pro Asp Leu Gly Gly Lys Ser Ser Thr Gln Glu Val Val Ala Asp 
            340                 345                 350         


Val Ile Arg Arg Leu 
        355         


<210>  88
<211>  361
<212>  PRT
<213>  Paracoccidioides brasiliensis

<400>  88

Met Ala Ala Arg Thr Leu Arg Ile Gly Leu Ile Pro Gly Asp Gly Ile 
1               5                   10                  15      


Gly Arg Glu Val Ile Pro Ala Gly Arg Arg Leu Leu Glu Ala Leu Pro 
            20                  25                  30          


Ser Ser Leu Gly Leu Lys Phe Ser Phe Val Asp Leu Glu Ala Gly Phe 
        35                  40                  45              


Asp Thr Phe Lys Lys Thr Gly Ala Ala Leu Pro Asp Lys Thr Val Glu 
    50                  55                  60                  


Val Leu Lys Lys Glu Cys Asp Gly Ala Leu Phe Gly Ala Val Ser Ser 
65                  70                  75                  80  


Pro Ser Thr Lys Val Ala Gly Tyr Ser Ser Pro Ile Val Ala Leu His 
                85                  90                  95      


Lys Arg Leu Asp Leu Tyr Ala Asn Val Arg Pro Val Arg Thr Thr Thr 
            100                 105                 110         


Gly Ser Ser Gly Thr Pro Ile Asp Leu Val Ile Val His Glu Asn Thr 
        115                 120                 125             


Glu Asp Leu Tyr Val Lys Glu Glu Lys Thr Arg Asp Thr Pro Asn Gly 
    130                 135                 140                 


Lys Val Ala Glu Ala Ile Lys Arg Ile Ser Glu His Ala Ser Phe Arg 
145                 150                 155                 160 


Ile Ala Thr Met Ala Gly Asp Ile Ala Leu Arg Arg Gln Lys Ile Arg 
                165                 170                 175     


Asp Ala Asp Pro Ser Thr Gln Ser Asn Ala Arg Ser Lys Pro Met Val 
            180                 185                 190         


Thr Ile Thr His Lys Ser Asn Val Leu Ser Gln Thr Asp Gly Leu Phe 
        195                 200                 205             


Arg Glu Thr Ala Arg Arg Ala Leu Ala Gln Thr Arg Phe Ala Glu Thr 
    210                 215                 220                 


Val Ala Val Glu Glu Gln Ile Val Asp Ser Met Val Tyr Lys Leu Phe 
225                 230                 235                 240 


Arg Gln Pro Ser Tyr Tyr Asp Val Ile Val Ala Pro Asn Leu Tyr Gly 
                245                 250                 255     


Asp Ile Leu Ser Asp Gly Ala Ala Ala Leu Val Gly Ser Leu Gly Leu 
            260                 265                 270         


Val Pro Ser Ala Asn Val Gly Asp Asn Phe Ala Ile Gly Glu Pro Cys 
        275                 280                 285             


His Gly Ser Ala Pro Asp Ile Glu Gly Lys Gly Ile Ala Asn Pro Ile 
    290                 295                 300                 


Ala Thr Leu Arg Ser Val Ala Leu Met Leu Glu Phe Leu Gly Glu Gly 
305                 310                 315                 320 


Lys Ala Ala Ala Ser Ile Tyr Lys Ala Val Asp Glu Asn Leu Asp Ala 
                325                 330                 335     


Gly Thr Phe Leu Ser Pro Asp Leu Gly Gly Lys Ala Lys Thr Asp Glu 
            340                 345                 350         


Val Leu Glu Asp Val Leu Lys Arg Leu 
        355                 360     


<210>  89
<211>  361
<212>  PRT
<213>  Paracoccidioides brasiliensis

<400>  89

Met Ala Ala Arg Thr Leu Arg Ile Gly Leu Ile Pro Gly Asp Gly Ile 
1               5                   10                  15      


Gly Arg Glu Val Ile Pro Ala Gly Arg Arg Leu Leu Glu Ala Leu Pro 
            20                  25                  30          


Ser Ser Leu Gly Leu Lys Phe Ser Phe Val Asp Leu Glu Ala Gly Phe 
        35                  40                  45              


Asp Thr Phe Lys Lys Thr Gly Ala Ala Leu Pro Asp Lys Thr Val Glu 
    50                  55                  60                  


Val Leu Lys Lys Glu Cys Asp Gly Ala Leu Phe Gly Ala Val Ser Ser 
65                  70                  75                  80  


Pro Ser Thr Lys Val Ala Gly Tyr Ser Ser Pro Ile Val Ala Leu His 
                85                  90                  95      


Lys Arg Leu Asp Leu Tyr Ala Asn Val Arg Pro Val Arg Thr Thr Thr 
            100                 105                 110         


Gly Ser Ser Gly Thr Pro Ile Asp Leu Val Ile Val His Glu Asn Thr 
        115                 120                 125             


Glu Asp Leu Tyr Val Lys Glu Glu Lys Thr Arg Asp Thr Pro Asn Gly 
    130                 135                 140                 


Lys Val Ala Glu Ala Ile Lys Arg Ile Ser Glu His Ala Ser Phe Arg 
145                 150                 155                 160 


Ile Ala Thr Met Ala Gly Asp Ile Ala Leu Arg Arg Gln Lys Ile Arg 
                165                 170                 175     


Asp Ala Asp Pro Ser Thr Gln Ser Asn Ala Arg Ser Lys Pro Met Val 
            180                 185                 190         


Thr Ile Thr His Lys Ser Asn Val Leu Ser Gln Thr Asp Gly Leu Phe 
        195                 200                 205             


Arg Glu Thr Ala Arg Arg Ala Leu Ala Gln Thr Arg Phe Ala Glu Thr 
    210                 215                 220                 


Val Ala Val Glu Glu Gln Ile Val Asp Ser Met Val Tyr Lys Leu Phe 
225                 230                 235                 240 


Arg Gln Pro Ser Tyr Tyr Asp Val Ile Val Ala Pro Asn Leu Tyr Gly 
                245                 250                 255     


Asp Ile Leu Ser Asp Gly Ala Ala Ala Leu Val Gly Ser Leu Gly Leu 
            260                 265                 270         


Val Pro Ser Ala Asn Val Gly Asp Asn Phe Ala Ile Gly Glu Pro Cys 
        275                 280                 285             


His Gly Ser Ala Pro Asp Ile Glu Gly Lys Gly Ile Ala Asn Pro Ile 
    290                 295                 300                 


Ala Thr Leu Arg Ser Val Ala Leu Met Leu Glu Phe Leu Gly Glu Gly 
305                 310                 315                 320 


Lys Ala Ala Ala Ser Ile Tyr Lys Ala Val Asp Glu Asn Leu Asp Ala 
                325                 330                 335     


Gly Thr Phe Leu Ser Pro Asp Leu Gly Gly Lys Ala Lys Thr Asp Glu 
            340                 345                 350         


Val Leu Glu Asp Val Leu Lys Arg Leu 
        355                 360     


<210>  90
<211>  361
<212>  PRT
<213>  Paracoccidioides brasiliensis

<400>  90

Met Ala Ala Arg Thr Leu Arg Ile Gly Leu Ile Pro Gly Asp Gly Ile 
1               5                   10                  15      


Gly Arg Glu Val Ile Pro Ala Gly Arg Arg Leu Leu Glu Ala Leu Pro 
            20                  25                  30          


Ser Ser Leu Gly Leu Lys Phe Ser Phe Val Asp Leu Glu Ala Gly Phe 
        35                  40                  45              


Asp Thr Phe Lys Lys Thr Gly Ala Ala Leu Pro Asp Lys Thr Val Glu 
    50                  55                  60                  


Val Leu Lys Lys Glu Cys Asp Gly Ala Leu Phe Gly Ala Val Ser Ser 
65                  70                  75                  80  


Pro Ser Thr Lys Val Ala Gly Tyr Ser Ser Pro Ile Val Ala Leu His 
                85                  90                  95      


Lys Arg Leu Asp Leu Tyr Ala Asn Val Arg Pro Val Arg Thr Thr Thr 
            100                 105                 110         


Gly Ser Ser Gly Thr Pro Ile Asp Leu Val Ile Val His Glu Asn Thr 
        115                 120                 125             


Glu Asp Leu Tyr Val Lys Glu Glu Lys Thr Ser Asp Thr Pro Asn Gly 
    130                 135                 140                 


Lys Val Ala Glu Ala Ile Lys Arg Ile Ser Glu His Ala Ser Phe Arg 
145                 150                 155                 160 


Ile Ala Thr Met Ala Gly Asp Ile Ala Leu Arg Arg Gln Lys Ile Arg 
                165                 170                 175     


Asp Ala Asp Pro Ser Thr Lys Ser Asn Ala Arg Ser Lys Pro Met Val 
            180                 185                 190         


Thr Ile Thr His Lys Ser Asn Val Leu Ser Gln Thr Asp Gly Leu Phe 
        195                 200                 205             


Arg Glu Thr Ala Arg Arg Ala Leu Ala Gln Thr Arg Phe Ala Gly Thr 
    210                 215                 220                 


Val Ala Val Glu Glu Gln Ile Val Asp Ser Met Val Tyr Lys Leu Phe 
225                 230                 235                 240 


Arg Gln Pro Ser Tyr Tyr Asp Val Ile Val Ala Pro Asn Leu Tyr Gly 
                245                 250                 255     


Asp Ile Leu Ser Asp Gly Ala Ala Ala Leu Val Gly Ser Leu Gly Leu 
            260                 265                 270         


Val Pro Ser Ala Asn Val Gly Asp Asn Phe Ala Ile Gly Glu Pro Cys 
        275                 280                 285             


His Gly Ser Ala Pro Asp Ile Glu Gly Lys Gly Ile Ala Asn Pro Ile 
    290                 295                 300                 


Ala Thr Leu Arg Ser Val Ala Leu Met Leu Glu Phe Leu Gly Glu Glu 
305                 310                 315                 320 


Lys Ala Ala Ala Ile Ile Tyr Lys Ala Val Asp Ala Asn Leu Asp Ala 
                325                 330                 335     


Gly Ala Phe Leu Ser Pro Asp Leu Gly Gly Lys Ala Lys Thr Asp Glu 
            340                 345                 350         


Val Leu Glu Asp Val Leu Arg Arg Leu 
        355                 360     


<210>  91
<211>  345
<212>  PRT
<213>  Pyrococcus horikoshii

<400>  91

Met Tyr Lys Val Ala Val Ile Lys Gly Asp Gly Ile Gly Pro Glu Val 
1               5                   10                  15      


Ile Asp Ala Ala Ile Arg Val Val Lys Ser Val Thr Asp Lys Ile Lys 
            20                  25                  30          


Phe Tyr Glu Phe Glu Gly Gly Leu Ser Val Phe Lys Lys Tyr Gly Val 
        35                  40                  45              


Pro Ile Arg Glu Glu Asp Leu Glu Glu Ile Arg Lys Met Asp Ala Ile 
    50                  55                  60                  


Leu Phe Gly Ala Thr Thr Thr Pro Phe Asp Val Pro Arg Tyr Lys Ser 
65                  70                  75                  80  


Leu Ile Ile Thr Leu His Lys Glu Leu Asp Leu Tyr Ala Asn Leu Arg 
                85                  90                  95      


Ile Ile Pro Asn Phe Lys Leu Arg Lys Glu Ile Ile Ile Val His Glu 
            100                 105                 110         


Asn Ser Glu Gly Leu Tyr Ser Gly Glu Gly Ala Tyr Asp Ser Asn Lys 
        115                 120                 125             


Val Val Asp Phe Arg Ile Ile Thr Arg Lys Gly Ala Glu Arg Ile Ala 
    130                 135                 140                 


Lys Phe Ala Val Lys Leu Ala Lys Asp Arg Ser Thr Phe Leu Thr Phe 
145                 150                 155                 160 


Val His Lys Ala Asn Ile Leu Glu Ser Asp Arg Phe Phe Arg Lys Ile 
                165                 170                 175     


Val Leu Asp Ile Ala Arg Lys Glu Asp Val Lys Val Arg Glu Glu Ile 
            180                 185                 190         


Val Asp Ser Phe Thr Ile Lys Leu Val Lys Asp Pro Trp Asn Leu Gly 
        195                 200                 205             


Ile Ile Leu Ser Glu Asn Met Phe Gly Asp Ile Leu Ser Asp Leu Ala 
    210                 215                 220                 


Thr Ile His Ala Gly Ser Ile Gly Ile Val Pro Ser Gly Asn Tyr Gly 
225                 230                 235                 240 


Glu Asp Ile Ala Leu Phe Glu Pro Ile His Gly Ser Ala Pro Asp Ile 
                245                 250                 255     


Ala Gly Lys Gly Ile Ala Asn Pro Ile Gly Ala Ile Leu Ser Ala Ala 
            260                 265                 270         


Met Met Leu Asp Tyr Leu Gly Leu Asp Gly Ser Ile Ile Trp Lys Ala 
        275                 280                 285             


Val Gly Arg Tyr Val Arg Arg Gly Asn Leu Thr Pro Asp Met Glu Gly 
    290                 295                 300                 


Arg Ala Thr Thr Leu Glu Val Thr Asn Gly Ile Ile Ser Glu Ile Tyr 
305                 310                 315                 320 


Arg Leu Asp Glu Tyr Glu Ile Asp Glu Val Trp Arg Asp Glu Val Arg 
                325                 330                 335     


Leu Gly Arg Ile Leu Leu Glu Ile Ser 
            340                 345 


<210>  92
<211>  362
<212>  PRT
<213>  Roseiflexus sp.

<400>  92

Met Ser Ala Ala Pro Tyr Thr Ile Leu Val Ile Pro Gly Asp Gly Ile 
1               5                   10                  15      


Gly Arg Glu Val Ile Pro Ala Ala Val Ala Val Leu Arg Ala Thr Gly 
            20                  25                  30          


Leu Pro Phe His Phe Glu Asn Ala Asp Ala Gly Trp Glu Cys Phe Gln 
        35                  40                  45              


Arg Gln Gly Glu Ala Leu Pro Ser Ala Thr Leu Thr Ala Ala Arg Ala 
    50                  55                  60                  


Ala Asp Ala Ile Leu Phe Gly Ala Val Ala Ser Pro Gly Tyr Pro Val 
65                  70                  75                  80  


Ala Gly Tyr Arg Ser Pro Ile Val Arg Leu His Arg Glu Leu Asp Leu 
                85                  90                  95      


Tyr Ala Asn Ile Arg Pro Val Phe Asp Asp Leu Pro Glu Asn Gly Ser 
            100                 105                 110         


Asn Pro Arg Arg Arg Lys Val Asp Leu Val Val Val His Glu Asn Thr 
        115                 120                 125             


Glu Asp Val Tyr Ala Gly Arg Glu Arg Val Glu Asp Asp Gly Ala Thr 
    130                 135                 140                 


Ala Ile Ala Glu Arg Val Ile Thr Arg Arg Ala Ser Ala Arg Ile Met 
145                 150                 155                 160 


Arg Val Ala Cys Asp Leu Ala Arg Ala Arg Arg Ser Ala Arg Asn Gly 
                165                 170                 175     


Ser Asp Ala Pro Pro Gly Arg Val Thr Val Val His Lys Ala Asn Val 
            180                 185                 190         


Leu Arg Glu Thr Cys Gly Leu Phe Arg Ser Val Ala Leu Glu Val Ala 
        195                 200                 205             


Gln Ala Tyr Pro Asp Leu Gln Ile Asp Glu Met Leu Val Asp Thr Cys 
    210                 215                 220                 


Ala Leu Gln Leu Ala Thr Arg Pro Glu Arg Phe Asp Val Ile Val Thr 
225                 230                 235                 240 


Thr Asn Leu Phe Gly Asp Ile Leu Ser Asp Val Ala Cys Ala Trp Gly 
                245                 250                 255     


Gly Gly Leu Gly Leu Ala Pro Ser Ala Asn Leu Gly Glu Arg His Ala 
            260                 265                 270         


Leu Phe Glu Pro Val His Gly Ala Ala Pro Asp Ile Ala Gly Lys Gly 
        275                 280                 285             


Ile Ala Asn Pro Leu Ala Ala Ile Gly Cys Thr Ala Leu Leu Leu Asp 
    290                 295                 300                 


His Leu Ala Gly Arg Ala Pro Ala Asp Leu Ala Ser Ala Met Arg Gly 
305                 310                 315                 320 


Trp Ser Ala Arg Ile Gln Arg Ala Ile Arg His Val Arg Ala Ala Gly 
                325                 330                 335     


Pro His Thr Pro Asp Leu Gly Gly Ser Ala Val Thr Thr Asp Ile Thr 
            340                 345                 350         


Asn Ala Val Leu Ser His Met Leu Thr Thr 
        355                 360         


<210>  93
<211>  371
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  93

Met Phe Arg Ser Val Ala Thr Arg Leu Ser Ala Cys Arg Gly Leu Ala 
1               5                   10                  15      


Ser Asn Ala Ala Arg Lys Ser Leu Thr Ile Gly Leu Ile Pro Gly Asp 
            20                  25                  30          


Gly Ile Gly Lys Glu Val Ile Pro Ala Gly Lys Gln Val Leu Glu Asn 
        35                  40                  45              


Leu Asn Ser Lys His Gly Leu Ser Phe Asn Phe Ile Asp Leu Tyr Ala 
    50                  55                  60                  


Gly Phe Gln Thr Phe Gln Glu Thr Gly Lys Ala Leu Pro Asp Glu Thr 
65                  70                  75                  80  


Val Lys Val Leu Lys Glu Gln Cys Gln Gly Ala Leu Phe Gly Ala Val 
                85                  90                  95      


Gln Ser Pro Thr Thr Lys Val Glu Gly Tyr Ser Ser Pro Ile Val Ala 
            100                 105                 110         


Leu His Arg Glu Met Gly Leu Phe Ala Asn Val Arg Pro Val Lys Ser 
        115                 120                 125             


Val Glu Gly Glu Lys Gly Lys Pro Ile Asp Met Val Ile Val His Glu 
    130                 135                 140                 


Asn Thr Glu Asp Leu Tyr Ile Lys Ile Glu Lys Thr Tyr Ile Asp Lys 
145                 150                 155                 160 


Ala Thr Gly Thr Arg Val Ala Asp Ala Thr Lys Arg Ile Ser Glu Ile 
                165                 170                 175     


Ala Thr Arg Arg Ile Ala Thr Ile Ala Leu Asp Ile Ala Leu Lys Arg 
            180                 185                 190         


Leu Gln Thr Arg Gly Gln Ala Thr Leu Thr Val Thr His Lys Ser Asn 
        195                 200                 205             


Val Leu Ser Gln Ser Asp Gly Leu Phe Arg Glu Ile Cys Lys Glu Val 
    210                 215                 220                 


Tyr Glu Ser Asn Lys Asp Lys Tyr Gly Gln Ile Lys Tyr Asn Glu Gln 
225                 230                 235                 240 


Ile Val Asp Ser Met Val Tyr Arg Leu Phe Arg Glu Pro Gln Cys Phe 
                245                 250                 255     


Asp Val Ile Val Ala Pro Asn Leu Tyr Gly Asp Ile Leu Ser Asp Gly 
            260                 265                 270         


Ala Ala Ala Leu Val Gly Ser Leu Gly Val Val Pro Ser Ala Asn Val 
        275                 280                 285             


Gly Pro Glu Ile Val Ile Gly Glu Pro Cys His Gly Ser Ala Pro Asp 
    290                 295                 300                 


Ile Ala Gly Lys Gly Ile Ala Asn Pro Ile Ala Thr Ile Arg Ser Thr 
305                 310                 315                 320 


Ala Leu Met Leu Glu Phe Leu Gly His Asn Glu Ala Ala Gln Asp Ile 
                325                 330                 335     


Tyr Lys Ala Val Asp Ala Asn Leu Arg Glu Gly Ser Ile Lys Thr Pro 
            340                 345                 350         


Asp Leu Gly Gly Lys Ala Ser Thr Gln Gln Val Val Asp Asp Val Leu 
        355                 360                 365             


Ser Arg Leu 
    370     


<210>  94
<211>  361
<212>  PRT
<213>  Schizosaccharomyces japonicus

<400>  94

Met Ala Ala Ile Arg Lys Ile Ile Leu Gly Leu Ile Pro Ala Asp Gly 
1               5                   10                  15      


Ile Gly Arg Glu Val Val Pro Ala Ala Val Arg Met Met Lys Asn Leu 
            20                  25                  30          


Pro Ala Lys His Asn Leu Gln Phe Asp Phe Val Asp Leu Asp Ala Gly 
        35                  40                  45              


Trp Gly Thr Phe Glu Arg Thr Gly Val Ala Leu Pro Glu Lys Thr Val 
    50                  55                  60                  


Glu Arg Leu Lys Thr Glu Cys Asn Ala Ala Leu Phe Gly Ala Val Gln 
65                  70                  75                  80  


Ser Pro Thr His Lys Val Ala Gly Tyr Ser Ser Pro Ile Val Ala Leu 
                85                  90                  95      


His Lys Leu Leu Gly Leu Tyr Ala Asn Val Arg Pro Val Lys Ser Leu 
            100                 105                 110         


Ala Asn Thr Lys Gly Lys Thr Val Asp Met Val Ile Val His Glu Asn 
        115                 120                 125             


Thr Glu Cys Leu Tyr Ile Lys Glu Glu Arg Met Val Val Glu Thr Pro 
    130                 135                 140                 


Gly Arg Arg Val Ser Glu Ala Ile Arg Arg Ile Ser Glu Glu Ala Ser 
145                 150                 155                 160 


Val Lys Ile Gly Lys Met Ala Tyr Gln Ile Ala Leu Ser Arg Gln Arg 
                165                 170                 175     


Ile Arg Asp Ala Gly Ala Ala Ser Ile His Ser Lys Pro Asn Val Thr 
            180                 185                 190         


Ile Ile His Lys Ser Asn Val Met Ser Val Thr Asp Gly Leu Phe Arg 
        195                 200                 205             


Glu Ser Cys Arg Tyr Ala Gln Thr Leu Asp Pro Ala Phe Ala Ser Val 
    210                 215                 220                 


Ser Val Asp Glu Gln Ile Val Asp Ser Met Val Tyr Arg Leu Phe Arg 
225                 230                 235                 240 


Glu Pro Gln Cys Phe Asp Val Val Val Ala Pro Asn Leu Tyr Gly Asp 
                245                 250                 255     


Ile Leu Ser Asp Gly Ala Ala Ser Leu Ile Gly Ser Leu Gly Leu Val 
            260                 265                 270         


Pro Ser Ala Asn Val Gly Asp Asp Phe Val Met Ser Glu Pro Val His 
        275                 280                 285             


Gly Ser Ala Pro Asp Ile Ala Gly Arg Gly Ile Ala Asn Pro Val Ala 
    290                 295                 300                 


Thr Phe Arg Ser Val Ala Leu Met Leu Glu Phe Met Gly His Gln Glu 
305                 310                 315                 320 


Ala Ala Ala Asp Ile Tyr Arg Ala Val Asp Ser Val Leu Met Glu Gly 
                325                 330                 335     


Lys Val Leu Thr Pro Asp Leu Gly Gly Lys Ser Gly Thr Asn Glu Ile 
            340                 345                 350         


Thr Asp Ala Val Ile Ala Lys Met Asn 
        355                 360     


<210>  95
<211>  361
<212>  PRT
<213>  Schizosaccharomyces japonicus

<400>  95

Met Ala Ala Ile Arg Lys Ile Ile Leu Gly Leu Ile Pro Ala Asp Gly 
1               5                   10                  15      


Ile Gly Arg Glu Val Val Pro Ala Ala Val Arg Met Met Lys Asn Leu 
            20                  25                  30          


Pro Ala Lys His Asn Leu Gln Phe Asp Phe Val Asp Leu Asp Ala Gly 
        35                  40                  45              


Trp Gly Thr Phe Glu Arg Thr Gly Val Ala Leu Pro Glu Lys Thr Val 
    50                  55                  60                  


Glu Arg Leu Lys Thr Glu Cys Asn Ala Ala Leu Phe Gly Ala Val Gln 
65                  70                  75                  80  


Ser Pro Thr His Lys Val Ala Gly Tyr Ser Ser Pro Ile Val Ala Leu 
                85                  90                  95      


His Lys Leu Leu Gly Leu Tyr Ala Asn Val Arg Pro Val Lys Ser Leu 
            100                 105                 110         


Ala Asn Thr Lys Gly Lys Thr Val Asp Met Val Ile Val His Glu Asn 
        115                 120                 125             


Thr Glu Cys Leu Tyr Ile Lys Glu Glu Arg Met Val Val Glu Thr Pro 
    130                 135                 140                 


Gly Arg Arg Val Ser Glu Ala Ile Arg Arg Ile Ser Glu Glu Ala Ser 
145                 150                 155                 160 


Val Lys Ile Gly Lys Met Ala Tyr Gln Ile Ala Leu Ser Arg Gln Arg 
                165                 170                 175     


Ile Arg Asp Ala Gly Ala Ala Ser Ile His Ser Lys Pro Asn Val Thr 
            180                 185                 190         


Ile Ile His Lys Ser Asn Val Met Ser Val Thr Asp Gly Leu Phe Arg 
        195                 200                 205             


Glu Ser Cys Arg Tyr Ala Gln Thr Leu Asp Pro Ala Phe Ala Ser Val 
    210                 215                 220                 


Ser Val Asp Glu Gln Ile Val Asp Ser Met Val Tyr Arg Leu Phe Arg 
225                 230                 235                 240 


Glu Pro Gln Cys Phe Asp Val Val Val Ala Pro Asn Leu Tyr Gly Asp 
                245                 250                 255     


Ile Leu Ser Asp Gly Ala Ala Ser Leu Ile Gly Ser Leu Gly Leu Val 
            260                 265                 270         


Pro Ser Ala Asn Val Gly Asp Asp Phe Val Met Ser Glu Pro Val His 
        275                 280                 285             


Gly Ser Ala Pro Asp Ile Ala Gly Arg Gly Ile Ala Asn Pro Val Ala 
    290                 295                 300                 


Thr Phe Arg Ser Val Ala Leu Met Leu Glu Phe Met Gly His Gln Glu 
305                 310                 315                 320 


Ala Ala Ala Asp Ile Tyr Arg Ala Val Asp Ser Val Leu Met Glu Gly 
                325                 330                 335     


Lys Val Leu Thr Pro Asp Leu Gly Gly Lys Ser Gly Thr Asn Glu Ile 
            340                 345                 350         


Thr Asp Ala Val Ile Ala Lys Met Asn 
        355                 360     


<210>  96
<211>  362
<212>  PRT
<213>  Schizosaccharomyces pombe

<400>  96

Met Ser Ala Thr Arg Arg Ile Val Leu Gly Leu Ile Pro Ala Asp Gly 
1               5                   10                  15      


Ile Gly Lys Glu Val Val Pro Ala Ala Arg Arg Leu Met Glu Asn Leu 
            20                  25                  30          


Pro Ala Lys His Lys Leu Lys Phe Asp Phe Ile Asp Leu Asp Ala Gly 
        35                  40                  45              


Trp Gly Thr Phe Glu Arg Thr Gly Lys Ala Leu Pro Glu Arg Thr Val 
    50                  55                  60                  


Glu Arg Leu Lys Thr Glu Cys Asn Ala Ala Leu Phe Gly Ala Val Gln 
65                  70                  75                  80  


Ser Pro Thr His Lys Val Ala Gly Tyr Ser Ser Pro Ile Val Ala Leu 
                85                  90                  95      


His Lys Lys Met Gly Leu Tyr Ala Asn Val Arg Pro Val Lys Ser Leu 
            100                 105                 110         


Asp Gly Ala Lys Gly Lys Pro Val Asp Leu Val Ile Val His Glu Asn 
        115                 120                 125             


Thr Glu Cys Leu Tyr Val Lys Glu Glu Arg Met Val Gln Asn Thr Pro 
    130                 135                 140                 


Gly Lys Arg Val Ala Glu Ala Ile Arg Arg Ile Ser Glu Glu Ala Ser 
145                 150                 155                 160 


Thr Lys Ile Gly Lys Met Ala Phe Glu Ile Ala Lys Ser Arg Gln Lys 
                165                 170                 175     


Ile Arg Glu Ser Gly Thr Tyr Ser Ile His Lys Lys Pro Leu Val Thr 
            180                 185                 190         


Ile Ile His Lys Ser Asn Val Met Ser Val Thr Asp Gly Leu Phe Arg 
        195                 200                 205             


Glu Ser Cys Arg His Ala Gln Ser Leu Asp Pro Ser Tyr Ala Ser Ile 
    210                 215                 220                 


Asn Val Asp Glu Gln Ile Val Asp Ser Met Val Tyr Arg Leu Phe Arg 
225                 230                 235                 240 


Glu Pro Glu Cys Phe Asp Val Val Val Ala Pro Asn Leu Tyr Gly Asp 
                245                 250                 255     


Ile Leu Ser Asp Gly Ala Ala Ser Leu Ile Gly Ser Leu Gly Leu Val 
            260                 265                 270         


Pro Ser Ala Asn Val Gly Asp Asn Phe Val Met Ser Glu Pro Val His 
        275                 280                 285             


Gly Ser Ala Pro Asp Ile Ala Gly Arg Gly Ile Ala Asn Pro Val Ala 
    290                 295                 300                 


Thr Phe Arg Ser Val Ala Leu Met Leu Glu Phe Met Gly His Gln Asp 
305                 310                 315                 320 


Ala Ala Ala Asp Ile Tyr Thr Ala Val Asp Lys Val Leu Thr Glu Gly 
                325                 330                 335     


Lys Val Leu Thr Pro Asp Leu Gly Gly Lys Ser Gly Thr Asn Glu Ile 
            340                 345                 350         


Thr Asp Ala Val Leu Ala Asn Ile His Asn 
        355                 360         


<210>  97
<211>  362
<212>  PRT
<213>  Schizosaccharomyces pombe

<400>  97

Met Ser Ala Thr Arg Arg Ile Val Leu Gly Leu Ile Pro Ala Asp Gly 
1               5                   10                  15      


Ile Gly Lys Glu Val Val Pro Ala Ala Arg Arg Leu Met Glu Asn Leu 
            20                  25                  30          


Pro Ala Lys His Lys Leu Lys Phe Asp Phe Ile Asp Leu Asp Ala Gly 
        35                  40                  45              


Trp Gly Thr Phe Glu Arg Thr Gly Lys Ala Leu Pro Glu Arg Thr Val 
    50                  55                  60                  


Glu Arg Leu Lys Thr Glu Cys Asn Ala Ala Leu Phe Gly Ala Val Gln 
65                  70                  75                  80  


Ser Pro Thr His Lys Val Ala Gly Tyr Ser Ser Pro Ile Val Ala Leu 
                85                  90                  95      


His Lys Lys Met Gly Leu Tyr Ala Asn Val Arg Pro Val Lys Ser Leu 
            100                 105                 110         


Asp Gly Ala Lys Gly Lys Pro Val Asp Leu Val Ile Val His Glu Asn 
        115                 120                 125             


Thr Glu Cys Leu Tyr Val Lys Glu Glu Arg Met Val Gln Asn Thr Pro 
    130                 135                 140                 


Gly Lys Arg Val Ala Glu Ala Ile Arg Arg Ile Ser Glu Glu Ala Ser 
145                 150                 155                 160 


Thr Lys Ile Gly Lys Met Ala Phe Glu Ile Ala Lys Ser Arg Gln Lys 
                165                 170                 175     


Ile Arg Glu Ser Gly Thr Tyr Ser Ile His Lys Lys Pro Leu Val Thr 
            180                 185                 190         


Ile Ile His Lys Ser Asn Val Met Ser Val Thr Asp Gly Leu Phe Arg 
        195                 200                 205             


Glu Ser Cys Arg His Ala Gln Ser Leu Asp Pro Ser Tyr Ala Ser Ile 
    210                 215                 220                 


Asn Val Asp Glu Gln Ile Val Asp Ser Met Val Tyr Arg Leu Phe Arg 
225                 230                 235                 240 


Glu Pro Glu Cys Phe Asp Val Val Val Ala Pro Asn Leu Tyr Gly Asp 
                245                 250                 255     


Ile Leu Ser Asp Gly Ala Ala Ser Leu Ile Gly Ser Leu Gly Leu Val 
            260                 265                 270         


Pro Ser Ala Asn Val Gly Asp Asn Phe Val Met Ser Glu Pro Val His 
        275                 280                 285             


Gly Ser Ala Pro Asp Ile Ala Gly Arg Gly Ile Ala Asn Pro Val Ala 
    290                 295                 300                 


Thr Phe Arg Ser Val Ala Leu Met Leu Glu Phe Met Gly His Gln Asp 
305                 310                 315                 320 


Ala Ala Ala Asp Ile Tyr Thr Ala Val Asp Lys Val Leu Thr Glu Gly 
                325                 330                 335     


Lys Val Leu Thr Pro Asp Leu Gly Gly Lys Ser Gly Thr Asn Glu Ile 
            340                 345                 350         


Thr Asp Ala Val Leu Ala Asn Ile His Asn 
        355                 360         


<210>  98
<211>  366
<212>  PRT
<213>  Schizosaccharomyces pombe

<400>  98

Gly Ser Thr Ser Met Ser Ala Thr Arg Arg Ile Val Leu Gly Leu Ile 
1               5                   10                  15      


Pro Ala Asp Gly Ile Gly Lys Glu Val Val Pro Ala Ala Arg Arg Leu 
            20                  25                  30          


Met Glu Asn Leu Pro Ala Lys His Lys Leu Lys Phe Asp Phe Ile Asp 
        35                  40                  45              


Leu Asp Ala Gly Trp Gly Thr Phe Glu Arg Thr Gly Lys Ala Leu Pro 
    50                  55                  60                  


Glu Arg Thr Val Glu Arg Leu Lys Thr Glu Cys Asn Ala Ala Leu Phe 
65                  70                  75                  80  


Gly Ala Val Gln Ser Pro Thr His Lys Val Ala Gly Tyr Ser Ser Pro 
                85                  90                  95      


Ile Val Ala Leu His Lys Lys Met Gly Leu Tyr Ala Asn Val Arg Pro 
            100                 105                 110         


Val Lys Ser Leu Asp Gly Ala Lys Gly Lys Pro Val Asp Leu Val Ile 
        115                 120                 125             


Val His Glu Asn Thr Glu Cys Leu Tyr Val Lys Glu Glu Arg Met Val 
    130                 135                 140                 


Gln Asn Thr Pro Gly Lys Arg Val Ala Glu Ala Ile Arg Arg Ile Ser 
145                 150                 155                 160 


Glu Glu Ala Ser Thr Lys Ile Gly Lys Met Ala Phe Glu Ile Ala Lys 
                165                 170                 175     


Ser Arg Gln Lys Ile Arg Glu Ser Gly Thr Tyr Ser Ile His Lys Lys 
            180                 185                 190         


Pro Leu Val Thr Ile Ile His Lys Ser Asn Val Met Ser Val Thr Asp 
        195                 200                 205             


Gly Leu Phe Arg Glu Ser Cys Arg His Ala Gln Ser Leu Asp Pro Ser 
    210                 215                 220                 


Tyr Ala Ser Ile Asn Val Asp Glu Gln Ile Val Asp Ser Met Val Tyr 
225                 230                 235                 240 


Arg Leu Phe Arg Glu Pro Glu Cys Phe Asp Val Val Val Ala Pro Asn 
                245                 250                 255     


Leu Tyr Gly Asp Ile Leu Ser Asp Gly Ala Ala Ser Leu Ile Gly Ser 
            260                 265                 270         


Leu Gly Leu Val Pro Ser Ala Asn Val Gly Asp Asn Phe Val Met Ser 
        275                 280                 285             


Glu Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly Arg Gly Ile Ala 
    290                 295                 300                 


Asn Pro Val Ala Thr Phe Arg Ser Val Ala Leu Met Leu Glu Phe Met 
305                 310                 315                 320 


Gly His Gln Asp Ala Ala Ala Asp Ile Tyr Thr Ala Val Asp Lys Val 
                325                 330                 335     


Leu Thr Glu Gly Lys Val Leu Thr Pro Asp Leu Gly Gly Lys Ser Gly 
            340                 345                 350         


Thr Asn Glu Ile Thr Asp Ala Val Leu Ala Asn Ile His Asn 
        355                 360                 365     


<210>  99
<211>  366
<212>  PRT
<213>  Schizosaccharomyces pombe

<400>  99

Gly Ser Thr Ser Met Ser Ala Thr Arg Arg Ile Val Leu Gly Leu Ile 
1               5                   10                  15      


Pro Ala Asp Gly Ile Gly Lys Glu Val Val Pro Ala Ala Arg Arg Leu 
            20                  25                  30          


Met Glu Asn Leu Pro Ala Lys His Lys Leu Lys Phe Asp Phe Ile Asp 
        35                  40                  45              


Leu Asp Ala Gly Trp Gly Thr Phe Glu Arg Thr Gly Lys Ala Leu Pro 
    50                  55                  60                  


Glu Arg Thr Val Glu Arg Leu Lys Thr Glu Cys Asn Ala Ala Leu Phe 
65                  70                  75                  80  


Gly Ala Val Gln Ser Pro Thr His Lys Val Ala Gly Tyr Ser Ser Pro 
                85                  90                  95      


Ile Val Ala Leu His Lys Lys Met Gly Leu Tyr Ala Asn Val Arg Pro 
            100                 105                 110         


Val Lys Ser Leu Asp Gly Ala Lys Gly Lys Pro Val Asp Leu Val Ile 
        115                 120                 125             


Val His Glu Asn Thr Glu Cys Leu Tyr Val Lys Glu Glu Arg Met Val 
    130                 135                 140                 


Gln Asn Thr Pro Gly Lys Arg Val Ala Glu Ala Ile Arg Arg Ile Ser 
145                 150                 155                 160 


Glu Glu Ala Ser Thr Lys Ile Gly Lys Met Ala Phe Glu Ile Ala Lys 
                165                 170                 175     


Ser Arg Gln Lys Ile Arg Glu Ser Gly Thr Tyr Ser Ile His Lys Lys 
            180                 185                 190         


Pro Leu Val Thr Ile Ile His Lys Ser Asn Val Met Ser Val Thr Asp 
        195                 200                 205             


Gly Leu Phe Arg Glu Ser Cys Arg His Ala Gln Ser Leu Asp Pro Ser 
    210                 215                 220                 


Tyr Ala Ser Ile Asn Val Asp Glu Gln Ile Val Asp Ser Met Val Tyr 
225                 230                 235                 240 


Arg Leu Phe Arg Glu Pro Glu Cys Phe Asp Val Val Val Ala Pro Asn 
                245                 250                 255     


Leu Tyr Gly Asp Ile Leu Ser Asp Gly Ala Ala Ser Leu Ile Gly Ser 
            260                 265                 270         


Leu Gly Leu Val Pro Ser Ala Asn Val Gly Asp Asn Phe Val Met Ser 
        275                 280                 285             


Glu Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly Arg Gly Ile Ala 
    290                 295                 300                 


Asn Pro Val Ala Thr Phe Arg Ser Val Ala Leu Met Leu Glu Phe Met 
305                 310                 315                 320 


Gly His Gln Asp Ala Ala Ala Asp Ile Tyr Thr Ala Val Asp Lys Val 
                325                 330                 335     


Leu Thr Glu Gly Lys Val Leu Thr Pro Asp Leu Gly Gly Lys Ser Gly 
            340                 345                 350         


Thr Asn Glu Ile Thr Asp Ala Val Leu Ala Asn Ile His Asn 
        355                 360                 365     


<210>  100
<211>  366
<212>  PRT
<213>  Schizosaccharomyces pombe

<400>  100

Gly Ser Thr Ser Met Ser Ala Thr Arg Arg Ile Val Leu Gly Leu Ile 
1               5                   10                  15      


Pro Ala Asp Gly Ile Gly Lys Glu Val Val Pro Ala Ala Arg Arg Leu 
            20                  25                  30          


Met Glu Asn Leu Pro Ala Lys His Lys Leu Lys Phe Asp Phe Ile Asp 
        35                  40                  45              


Leu Asp Ala Gly Trp Gly Thr Phe Glu Arg Thr Gly Lys Ala Leu Pro 
    50                  55                  60                  


Glu Arg Thr Val Glu Arg Leu Lys Thr Glu Cys Asn Ala Ala Leu Phe 
65                  70                  75                  80  


Gly Ala Val Gln Ser Pro Thr His Lys Val Ala Gly Tyr Ser Ser Pro 
                85                  90                  95      


Ile Val Ala Leu His Lys Lys Met Gly Leu Tyr Ala Asn Val Arg Pro 
            100                 105                 110         


Val Lys Ser Leu Asp Gly Ala Lys Gly Lys Pro Val Asp Leu Val Ile 
        115                 120                 125             


Val His Glu Asn Thr Glu Cys Leu Tyr Val Lys Glu Glu Arg Met Val 
    130                 135                 140                 


Gln Asn Thr Pro Gly Lys Arg Val Ala Glu Ala Ile Arg Arg Ile Ser 
145                 150                 155                 160 


Glu Glu Ala Ser Thr Lys Ile Gly Lys Met Ala Phe Glu Ile Ala Lys 
                165                 170                 175     


Ser Arg Gln Lys Ile Arg Glu Ser Gly Thr Tyr Ser Ile His Lys Lys 
            180                 185                 190         


Pro Leu Val Thr Ile Ile His Lys Ser Asn Val Met Ser Val Thr Asp 
        195                 200                 205             


Gly Leu Phe Arg Glu Ser Cys Arg His Ala Gln Ser Leu Asp Pro Ser 
    210                 215                 220                 


Tyr Ala Ser Ile Asn Val Asp Glu Gln Ile Val Asp Ser Met Val Tyr 
225                 230                 235                 240 


Arg Leu Phe Arg Glu Pro Glu Cys Phe Asp Val Val Val Ala Pro Asn 
                245                 250                 255     


Leu Tyr Gly Asp Ile Leu Ser Asp Gly Ala Ala Ser Leu Ile Gly Ser 
            260                 265                 270         


Leu Gly Leu Val Pro Ser Ala Asn Val Gly Asp Asn Phe Val Met Ser 
        275                 280                 285             


Glu Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly Arg Gly Ile Ala 
    290                 295                 300                 


Asn Pro Val Ala Thr Phe Arg Ser Val Ala Leu Met Leu Glu Phe Met 
305                 310                 315                 320 


Gly His Gln Asp Ala Ala Ala Asp Ile Tyr Thr Ala Val Asp Lys Val 
                325                 330                 335     


Leu Thr Glu Gly Lys Val Leu Thr Pro Asp Leu Gly Gly Lys Ser Gly 
            340                 345                 350         


Thr Asn Glu Ile Thr Asp Ala Val Leu Ala Asn Ile His Asn 
        355                 360                 365     


<210>  101
<211>  366
<212>  PRT
<213>  Schizosaccharomyces pombe

<400>  101

Gly Ser Thr Ser Met Ser Ala Thr Arg Arg Ile Val Leu Gly Leu Ile 
1               5                   10                  15      


Pro Ala Asp Gly Ile Gly Lys Glu Val Val Pro Ala Ala Arg Arg Leu 
            20                  25                  30          


Met Glu Asn Leu Pro Ala Lys His Lys Leu Lys Phe Asp Phe Ile Asp 
        35                  40                  45              


Leu Asp Ala Gly Trp Gly Thr Phe Glu Arg Thr Gly Lys Ala Leu Pro 
    50                  55                  60                  


Glu Arg Thr Val Glu Arg Leu Lys Thr Glu Cys Asn Ala Ala Leu Phe 
65                  70                  75                  80  


Gly Ala Val Gln Ser Pro Thr His Lys Val Ala Gly Tyr Ser Ser Pro 
                85                  90                  95      


Ile Val Ala Leu His Lys Lys Met Gly Leu Tyr Ala Asn Val Arg Pro 
            100                 105                 110         


Val Lys Ser Leu Asp Gly Ala Lys Gly Lys Pro Val Asp Leu Val Ile 
        115                 120                 125             


Val His Glu Asn Thr Glu Cys Leu Tyr Val Lys Glu Glu Arg Met Val 
    130                 135                 140                 


Gln Asn Thr Pro Gly Lys Arg Val Ala Glu Ala Ile Arg Arg Ile Ser 
145                 150                 155                 160 


Glu Glu Ala Ser Thr Lys Ile Gly Lys Met Ala Phe Glu Ile Ala Lys 
                165                 170                 175     


Ser Arg Gln Lys Ile Arg Glu Ser Gly Thr Tyr Ser Ile His Lys Lys 
            180                 185                 190         


Pro Leu Val Thr Ile Ile His Lys Ser Asn Val Met Ser Val Thr Asp 
        195                 200                 205             


Gly Leu Phe Arg Glu Ser Cys Arg His Ala Gln Ser Leu Asp Pro Ser 
    210                 215                 220                 


Tyr Ala Ser Ile Asn Val Asp Glu Gln Ile Val Asp Ser Met Val Tyr 
225                 230                 235                 240 


Arg Leu Phe Arg Glu Pro Glu Cys Phe Asp Val Val Val Ala Pro Asn 
                245                 250                 255     


Leu Tyr Gly Asp Ile Leu Ser Asp Gly Ala Ala Ser Leu Ile Gly Ser 
            260                 265                 270         


Leu Gly Leu Val Pro Ser Ala Asn Val Gly Asp Asn Phe Val Met Ser 
        275                 280                 285             


Glu Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly Arg Gly Ile Ala 
    290                 295                 300                 


Asn Pro Val Ala Thr Phe Arg Ser Val Ala Leu Met Leu Glu Phe Met 
305                 310                 315                 320 


Gly His Gln Asp Ala Ala Ala Asp Ile Tyr Thr Ala Val Asp Lys Val 
                325                 330                 335     


Leu Thr Glu Gly Lys Val Leu Thr Pro Asp Leu Gly Gly Lys Ser Gly 
            340                 345                 350         


Thr Asn Glu Ile Thr Asp Ala Val Leu Ala Asn Ile His Asn 
        355                 360                 365     


<210>  102
<211>  362
<212>  PRT
<213>  Schizosaccharomyces pombe

<400>  102

Met Ser Ala Thr Arg Arg Ile Val Leu Gly Leu Ile Pro Ala Asp Gly 
1               5                   10                  15      


Ile Gly Lys Glu Val Val Pro Ala Ala Arg Arg Leu Met Glu Asn Leu 
            20                  25                  30          


Pro Ala Lys His Lys Leu Lys Phe Asp Phe Ile Asp Leu Asp Ala Gly 
        35                  40                  45              


Trp Gly Thr Phe Glu Arg Thr Gly Lys Ala Leu Pro Glu Arg Thr Val 
    50                  55                  60                  


Glu Arg Leu Lys Thr Glu Cys Asn Ala Ala Leu Phe Gly Ala Val Gln 
65                  70                  75                  80  


Ser Pro Thr His Lys Val Ala Gly Tyr Ser Ser Pro Ile Val Ala Leu 
                85                  90                  95      


His Lys Lys Met Gly Leu Tyr Ala Asn Val Arg Pro Val Lys Ser Leu 
            100                 105                 110         


Asp Gly Ala Lys Gly Lys Pro Val Asp Leu Val Ile Val His Glu Asn 
        115                 120                 125             


Thr Glu Cys Leu Tyr Val Lys Glu Glu Arg Met Val Gln Asn Thr Pro 
    130                 135                 140                 


Gly Lys Arg Val Ala Glu Ala Ile Arg Arg Ile Ser Glu Glu Ala Ser 
145                 150                 155                 160 


Thr Lys Ile Gly Lys Met Ala Phe Glu Ile Ala Lys Ser Arg Gln Lys 
                165                 170                 175     


Ile Arg Glu Ser Gly Thr Tyr Ser Ile His Lys Lys Pro Leu Val Thr 
            180                 185                 190         


Ile Ile His Lys Ser Asn Val Met Ser Val Thr Asp Gly Leu Phe Arg 
        195                 200                 205             


Glu Ser Cys Arg His Ala Gln Ser Leu Asp Pro Ser Tyr Ala Ser Ile 
    210                 215                 220                 


Asn Val Asp Glu Gln Ile Val Asp Ser Met Val Tyr Arg Leu Phe Arg 
225                 230                 235                 240 


Glu Pro Glu Cys Phe Asp Val Val Val Ala Pro Asn Leu Tyr Gly Asp 
                245                 250                 255     


Ile Leu Ser Asp Gly Ala Ala Ser Leu Ile Gly Ser Leu Gly Leu Val 
            260                 265                 270         


Pro Ser Ala Asn Val Gly Asp Asn Phe Val Met Ser Glu Pro Val His 
        275                 280                 285             


Gly Ser Ala Pro Asp Ile Ala Gly Arg Gly Ile Ala Asn Pro Val Ala 
    290                 295                 300                 


Thr Phe Arg Ser Val Ala Leu Met Leu Glu Phe Met Gly His Gln Asp 
305                 310                 315                 320 


Ala Ala Ala Asp Ile Tyr Thr Ala Val Asp Lys Val Leu Thr Glu Gly 
                325                 330                 335     


Lys Val Leu Thr Pro Asp Leu Gly Gly Lys Ser Gly Thr Asn Glu Ile 
            340                 345                 350         


Thr Asp Ala Val Leu Ala Asn Ile His Asn 
        355                 360         


<210>  103
<211>  361
<212>  PRT
<213>  Starkeya novella

<400>  103

Met Gln Leu Leu Val Leu Pro Gly Asp Gly Ile Gly Pro Glu Ile Thr 
1               5                   10                  15      


Ala Ala Thr Leu Arg Ala Leu Asn Val Leu Asn Asp Arg Cys Ala Val 
            20                  25                  30          


Asp Val Arg Trp Ser Glu Ala Asp Ile Gly Leu Lys Ser Leu Arg Glu 
        35                  40                  45              


Gln Gly Thr Thr Leu Pro Gly Ala Ile Ile Asp Gly Val Gln Thr Ala 
    50                  55                  60                  


Asp Gly Val Leu Leu Gly Pro Val Ser His Tyr Glu Tyr Pro Ser Arg 
65                  70                  75                  80  


Gln Glu Gly Ser Ile Asn Pro Ser Gly Glu Leu His Thr Arg Phe Glu 
                85                  90                  95      


Leu Phe Ala Asn Ile Arg Pro Cys Arg Ser Leu Ser Asp Leu Ser Ile 
            100                 105                 110         


Leu Arg Arg Pro Met Asp Leu Ile Ile Val His Glu Asn Thr Glu Gly 
        115                 120                 125             


Phe Tyr Ser Asp Arg Ser Met Ala Ala Gly Thr Gly Glu Leu Met Pro 
    130                 135                 140                 


Asp Glu Asn Met Ala Leu Ser Val Arg Lys Ile Thr Ala Arg Ala Ser 
145                 150                 155                 160 


Gly Gln Val Ala Arg Ala Ala Phe Glu Leu Ala Arg Gly Arg Arg Lys 
                165                 170                 175     


Lys Val Thr Ala Val His Lys Ala Asn Val Leu Lys Leu Ser Asp Gly 
            180                 185                 190         


Leu Phe Leu Arg Glu Val Arg Lys Val Ala Ala Asp Tyr Pro Asp Val 
        195                 200                 205             


Ala Leu Glu Glu Leu Ile Val Asp Ala Thr Ala Ala His Leu Ile Arg 
    210                 215                 220                 


Thr Pro Asp Ser Phe Asp Val Ile Val Thr Thr Asn Met Phe Gly Asp 
225                 230                 235                 240 


Ile Leu Ser Asp Glu Ala Ser Glu Leu Cys Gly Ser Leu Gly Leu Ala 
                245                 250                 255     


Gly Ser Ile Ser Ile Gly Asp Gly Val Cys Val Ala Gln Ala Gln His 
            260                 265                 270         


Gly Ser Ala Pro Asp Ile Ala Ser Arg Gly Ile Ala Asn Pro Thr Ser 
        275                 280                 285             


Leu Met Leu Ser Ala Ala Met Leu Leu Asp Trp Arg Gly Arg Arg Asp 
    290                 295                 300                 


Gly Ser Lys Pro Leu Ile Asp Ala Ala Ala Ala Leu Asp Gln Ala Val 
305                 310                 315                 320 


Ser Lys Val Leu Val Asp Pro Ala Thr Arg Thr Pro Asp Leu Gly Gly 
                325                 330                 335     


Thr Leu Ser Thr Glu Ala Phe Thr Asp Ala Val Arg Ala Ala Ile Thr 
            340                 345                 350         


Arg Ser Ser Ala Ala Gly Arg Ala Ala 
        355                 360     


<210>  104
<211>  361
<212>  PRT
<213>  Starkeya novella

<400>  104

Met Gln Leu Leu Val Leu Pro Gly Asp Gly Ile Gly Pro Glu Ile Thr 
1               5                   10                  15      


Ala Ala Thr Leu Arg Ala Leu Asn Val Leu Asn Asp Arg Cys Ala Val 
            20                  25                  30          


Asp Val Arg Trp Ser Glu Ala Asp Ile Gly Leu Lys Ser Leu Arg Glu 
        35                  40                  45              


Gln Gly Thr Thr Leu Pro Gly Ala Ile Ile Asp Gly Val Gln Thr Ala 
    50                  55                  60                  


Asp Gly Val Leu Leu Gly Pro Val Ser His Tyr Glu Tyr Pro Ser Arg 
65                  70                  75                  80  


Gln Glu Gly Ser Ile Asn Pro Ser Gly Glu Leu His Thr Arg Phe Glu 
                85                  90                  95      


Leu Phe Ala Asn Ile Arg Pro Cys Arg Ser Leu Ser Asp Leu Ser Ile 
            100                 105                 110         


Leu Arg Arg Pro Met Asp Leu Ile Ile Val His Glu Asn Thr Glu Gly 
        115                 120                 125             


Phe Tyr Ser Asp Arg Ser Met Ala Ala Gly Thr Gly Glu Leu Met Pro 
    130                 135                 140                 


Asp Glu Asn Met Ala Leu Ser Val Arg Lys Ile Thr Ala Arg Ala Ser 
145                 150                 155                 160 


Gly Gln Val Ala Arg Ala Ala Phe Glu Leu Ala Arg Gly Arg Arg Lys 
                165                 170                 175     


Lys Val Thr Ala Val His Lys Ala Asn Val Leu Lys Leu Ser Asp Gly 
            180                 185                 190         


Leu Phe Leu Arg Glu Val Arg Lys Val Ala Ala Asp Tyr Pro Asp Val 
        195                 200                 205             


Ala Leu Glu Glu Leu Ile Val Asp Ala Thr Ala Ala His Leu Ile Arg 
    210                 215                 220                 


Thr Pro Asp Ser Phe Asp Val Ile Val Thr Thr Asn Met Phe Gly Asp 
225                 230                 235                 240 


Ile Leu Ser Asp Glu Ala Ser Glu Leu Cys Gly Ser Leu Gly Leu Ala 
                245                 250                 255     


Gly Ser Ile Ser Ile Gly Asp Gly Val Cys Val Ala Gln Ala Gln His 
            260                 265                 270         


Gly Ser Ala Pro Asp Ile Ala Ser Arg Gly Ile Ala Asn Pro Thr Ser 
        275                 280                 285             


Leu Met Leu Ser Ala Ala Met Leu Leu Asp Trp Arg Gly Arg Arg Asp 
    290                 295                 300                 


Gly Ser Lys Pro Leu Ile Asp Ala Ala Ala Ala Leu Asp Gln Ala Val 
305                 310                 315                 320 


Ser Lys Val Leu Val Asp Pro Ala Thr Arg Thr Pro Asp Leu Gly Gly 
                325                 330                 335     


Thr Leu Ser Thr Glu Ala Phe Thr Asp Ala Val Arg Ala Ala Ile Thr 
            340                 345                 350         


Arg Ser Ser Ala Ala Gly Arg Ala Ala 
        355                 360     


<210>  105
<211>  368
<212>  PRT
<213>  Streptococcus vestibularis

<400>  105

Met Lys Ser Ile Ala Val Leu Pro Gly Asp Gly Ile Gly Ile Glu Val 
1               5                   10                  15      


Met Glu Ala Cys Val Pro Ile Phe Lys Glu Leu Asn Leu Asp Ile Lys 
            20                  25                  30          


Leu Lys Tyr Gly Glu Ile Gly Trp Lys Cys Trp Ile Asn Ser Ala Asn 
        35                  40                  45              


Pro Val Pro Asn Glu Thr Trp Asn Leu Ile Lys Asn Cys Asp Ala Val 
    50                  55                  60                  


Leu Val Gly Ala Ile Thr Ser Lys Pro Lys His Glu Ala Glu Gln Glu 
65                  70                  75                  80  


Leu Lys Val Lys Ser Ser Asn Thr Thr Asp Tyr Val Ser Pro Val Ile 
                85                  90                  95      


Gln Leu His Gln Lys Leu Gln Leu Phe Ala Asn Val Arg Pro Ile Val 
            100                 105                 110         


Ser Leu Ile Asn Asn Lys Ser Phe Glu Val Tyr Ile Ile His Glu Asn 
        115                 120                 125             


Thr Glu Gly Leu Tyr Ser Gly Leu Asp Phe Asn Pro Ile Pro Glu Pro 
    130                 135                 140                 


Leu Glu Asn Phe Ile Asn Glu Ser Thr Ser Lys Tyr Ser Asn Lys Leu 
145                 150                 155                 160 


Lys Asn Gly Ala Ala Thr Ile Arg Ile Ile Thr Glu Glu Gly Phe Asn 
                165                 170                 175     


Arg Leu Leu Lys Phe Ser Ser Glu Trp Ala Leu Lys His Gly Lys Ser 
            180                 185                 190         


Asn Ile Val Ile Ala Asp Lys Pro Asn Val Phe Arg Asn Ser Ser Asp 
        195                 200                 205             


Ile Ile Phe Arg Leu Ile Lys Lys Tyr Ser Leu Asp Tyr Pro Met Leu 
    210                 215                 220                 


Asn Tyr Thr Val Glu Asn Ile Asp Ala Val Ala Met Trp Leu Val Lys 
225                 230                 235                 240 


Lys Pro Gln Lys Tyr Glu Ile Val Ile Cys Glu Asn Gln Phe Gly Asp 
                245                 250                 255     


Ile Leu Ser Asp Val Gly Ala Ala Val Met Gly Gly Leu Gly Leu Ala 
            260                 265                 270         


Tyr Ser Gly Asn Tyr Gly Leu Lys Glu Thr Ala Tyr Phe Glu Pro Val 
        275                 280                 285             


His Gly Ser Ala Pro Lys Tyr Ser Gly Gln Asn Lys Val Asn Pro Met 
    290                 295                 300                 


Ala Met Phe Leu Ser Ile Ala Met Leu Leu Asn Phe Leu Gly Tyr Lys 
305                 310                 315                 320 


Glu Ala Ser Gln Ser Ile Gln Lys Ala Val Glu Tyr Thr Ala Lys Asp 
                325                 330                 335     


Lys Arg Phe Cys Thr Phe Asp Leu Ser Gly Ala Ala Thr Leu Ser Glu 
            340                 345                 350         


Ser Ala Lys His Ile Ile Glu Glu Ala Val Lys Ile Tyr Gly Asn Leu 
        355                 360                 365             


<210>  106
<211>  368
<212>  PRT
<213>  Streptococcus vestibularis

<400>  106

Met Lys Ser Ile Ala Val Leu Pro Gly Asp Gly Ile Gly Ile Glu Val 
1               5                   10                  15      


Met Glu Ala Cys Val Pro Ile Phe Lys Glu Leu Asn Leu Asp Ile Lys 
            20                  25                  30          


Leu Lys Tyr Gly Glu Ile Gly Trp Lys Cys Trp Ile Asn Ser Ala Asn 
        35                  40                  45              


Pro Val Pro Asn Glu Thr Trp Asn Leu Ile Lys Asn Cys Asp Ala Val 
    50                  55                  60                  


Leu Val Gly Ala Ile Thr Ser Lys Pro Lys His Glu Ala Glu Gln Glu 
65                  70                  75                  80  


Leu Lys Val Lys Ser Ser Asn Thr Thr Asp Tyr Val Ser Pro Val Ile 
                85                  90                  95      


Gln Leu His Gln Lys Leu Gln Leu Phe Ala Asn Val Arg Pro Ile Val 
            100                 105                 110         


Ser Leu Ile Asn Asn Lys Ser Phe Glu Val Tyr Ile Ile His Glu Asn 
        115                 120                 125             


Thr Glu Gly Leu Tyr Ser Gly Leu Asp Phe Asn Pro Ile Pro Glu Pro 
    130                 135                 140                 


Leu Glu Asn Phe Ile Asn Glu Ser Thr Ser Lys Tyr Ser Asn Lys Leu 
145                 150                 155                 160 


Lys Asn Gly Ala Ala Thr Ile Arg Ile Ile Thr Glu Glu Gly Phe Asn 
                165                 170                 175     


Arg Leu Leu Lys Phe Ser Ser Glu Trp Ala Leu Lys His Gly Lys Ser 
            180                 185                 190         


Asn Ile Val Ile Ala Asp Lys Pro Asn Val Phe Arg Asn Ser Ser Asp 
        195                 200                 205             


Ile Ile Phe Arg Leu Ile Lys Lys Tyr Ser Leu Asp Tyr Pro Met Leu 
    210                 215                 220                 


Asn Tyr Thr Val Glu Asn Ile Asp Ala Val Ala Met Trp Leu Val Lys 
225                 230                 235                 240 


Lys Pro Gln Lys Tyr Glu Ile Val Ile Cys Glu Asn Gln Phe Gly Asp 
                245                 250                 255     


Ile Leu Ser Asp Val Gly Ala Ala Val Met Gly Gly Leu Gly Leu Ala 
            260                 265                 270         


Tyr Ser Gly Asn Tyr Gly Leu Lys Glu Thr Ala Tyr Phe Glu Pro Val 
        275                 280                 285             


His Gly Ser Ala Pro Lys Tyr Ser Gly Gln Asn Lys Val Asn Pro Met 
    290                 295                 300                 


Ala Met Phe Leu Ser Ile Ala Met Leu Leu Asn Phe Leu Gly Tyr Lys 
305                 310                 315                 320 


Glu Ala Ser Gln Ser Ile Gln Lys Ala Val Glu Tyr Thr Ala Lys Asp 
                325                 330                 335     


Lys Arg Phe Cys Thr Phe Asp Leu Ser Gly Ala Ala Thr Leu Ser Glu 
            340                 345                 350         


Ser Ala Lys His Ile Ile Glu Glu Ala Val Lys Ile Tyr Gly Asn Leu 
        355                 360                 365             


<210>  107
<211>  347
<212>  PRT
<213>  Thermococcus kodakarensis

<400>  107

Met Tyr Arg Val Ala Val Ile Pro Gly Asp Gly Ile Gly Pro Glu Val 
1               5                   10                  15      


Ile Asp Gly Ala Val Arg Val Leu Lys Ala Val Thr Gly Arg Val Arg 
            20                  25                  30          


Phe Glu Tyr Tyr Glu Gly Gly Val Asp Val Phe Gln Glu Cys Gly Ser 
        35                  40                  45              


Pro Ile Arg Glu Glu Asp Leu Glu Glu Ile Arg Arg Ser Asp Ala Val 
    50                  55                  60                  


Leu Phe Gly Ala Thr Thr Thr Pro Phe Asp Leu Pro Gly Tyr Arg Ser 
65                  70                  75                  80  


Leu Ile Leu Thr Leu His Lys Glu Leu Gly Leu Tyr Ala Asn Leu Arg 
                85                  90                  95      


Ile Ile Pro Asp Leu Arg Thr Gly Arg Glu Ile Val Ile Val His Glu 
            100                 105                 110         


Asn Ser Glu Gly Leu Tyr Phe Gly Ile Gly Ala Val Val Asn Gly Arg 
        115                 120                 125             


Ala Val Asp Val Arg Leu Ile Thr Arg Glu Gly Ala Glu Arg Ile Ala 
    130                 135                 140                 


Arg Phe Ala Val Glu Gln Ala Lys Ala Arg Gly Ser Phe Ile Thr Phe 
145                 150                 155                 160 


Val His Lys Ala Asn Val Leu Thr Gly Asp Lys Phe Phe Arg Arg Ile 
                165                 170                 175     


Val Arg Glu Val Ala Gly Glu Glu Gly Val Glu Val Arg Asp Ala Ile 
            180                 185                 190         


Ile Asp Ser Phe Thr Ile Lys Leu Val Arg Asn Pro Trp Glu His Gly 
        195                 200                 205             


Val Ile Leu Ser Glu Asn Leu Phe Gly Asp Ile Leu Ser Asp Leu Ala 
    210                 215                 220                 


Thr Val His Ala Gly Ser Ile Gly Ile Val Pro Ser Gly Asn Tyr Gly 
225                 230                 235                 240 


Asp Gly Ile Ala Leu Phe Glu Pro Val His Gly Ser Ala Pro Asp Ile 
                245                 250                 255     


Ala Gly Lys Gly Ile Ala Asn Pro Ile Gly Ala Ile Leu Ser Gly Ala 
            260                 265                 270         


Met Leu Leu Asp Tyr Leu Gly Leu Asp Gly Ser Leu Ile Arg Ala Ala 
        275                 280                 285             


Val Arg Gly Tyr Val Val Asn Gly Glu Leu Thr Pro Asp Met Gly Gly 
    290                 295                 300                 


Arg Ala Arg Thr Glu Asp Val Val Arg Gly Ile Ile Gly Glu Ile Glu 
305                 310                 315                 320 


Asp Leu Leu Ser Met Asp Glu Val Trp Arg Asp Glu Ile Arg Leu Ser 
                325                 330                 335     


Arg Leu Glu Ser Asp Ile Ser Arg Met Ala Gly 
            340                 345         


<210>  108
<211>  334
<212>  PRT
<213>  Thermus aquaticus

<400>  108

Met Ala Tyr Arg Ile Cys Leu Ile Glu Gly Asp Gly Ile Gly His Glu 
1               5                   10                  15      


Val Val Pro Ala Ala Arg Arg Val Leu Glu Ala Thr Gly Leu Pro Leu 
            20                  25                  30          


Glu Phe Val Glu Ala Glu Ala Gly Trp Glu Thr Phe Glu Arg Arg Gly 
        35                  40                  45              


Val Ser Val Pro Glu Glu Thr Val Glu Lys Ile Leu Ser Cys His Ala 
    50                  55                  60                  


Thr Leu Phe Gly Ala Ala Thr Ser Pro Thr Arg Lys Val Pro Gly Phe 
65                  70                  75                  80  


Phe Gly Ala Ile Arg Tyr Leu His Arg Arg Leu Asp Leu Tyr Ala Asn 
                85                  90                  95      


Val Arg Pro Ala Lys Ser Arg Pro Ile Pro Gln Ser Arg Pro Gly Val 
            100                 105                 110         


Asp Leu Ile Ile Val His Glu Asn Thr Glu Gly Leu Tyr Val Glu Gln 
        115                 120                 125             


Glu Arg Arg Tyr Leu Asp Val Ala Ile Ala Asp Ala Val Ile Ser Lys 
    130                 135                 140                 


Lys Ala Ser Glu Arg Ile Gly Arg Val Ala Leu Lys Ile Ala Glu Gly 
145                 150                 155                 160 


Arg Pro Cys Lys Thr Leu His Ile Ala His Lys Ala Asn Val Leu Pro 
                165                 170                 175     


Val Thr Gln Gly Leu Phe Leu Asp Thr Val Lys Glu Ala Ala Arg Asp 
            180                 185                 190         


Phe Pro Leu Val Asn Val Gln Asp Ile Ile Val Asp Asn Cys Ala Met 
        195                 200                 205             


Gln Leu Val Met Arg Pro Glu Arg Phe Asp Val Ile Val Thr Thr Asn 
    210                 215                 220                 


Leu Leu Gly Asp Ile Leu Ser Asp Leu Thr Ala Gly Leu Val Gly Gly 
225                 230                 235                 240 


Leu Gly Leu Ala Pro Ser Ala Asn Ile Gly Asp Thr Thr Ala Val Phe 
                245                 250                 255     


Glu Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly Lys Gly Ile Ala 
            260                 265                 270         


Asn Pro Thr Ala Thr Ile Leu Ser Ala Ala Met Met Leu Asp Tyr Leu 
        275                 280                 285             


Gly Glu Arg Glu Val Ala Arg Lys Val Glu Arg Ala Val Asp Leu Val 
    290                 295                 300                 


Leu Glu Lys Gly Pro Arg Thr Pro Asp Leu Gly Gly Glu Ala Thr Thr 
305                 310                 315                 320 


Glu Thr Phe Thr Gln Ala Val Ile Glu Ala Leu Lys Ala Leu 
                325                 330                 


<210>  109
<211>  334
<212>  PRT
<213>  Thermus aquaticus

<400>  109

Met Ala Tyr Arg Ile Cys Leu Ile Glu Gly Asp Gly Ile Gly His Glu 
1               5                   10                  15      


Val Val Pro Ala Ala Arg Lys Val Leu Glu Ala Thr Gly Leu Pro Leu 
            20                  25                  30          


Glu Phe Val Glu Ala Glu Ala Gly Trp Glu Thr Phe Glu Arg Arg Gly 
        35                  40                  45              


Val Ser Val Pro Glu Glu Thr Val Glu Lys Ile Leu Ser Cys His Ala 
    50                  55                  60                  


Thr Leu Phe Gly Ala Ala Thr Ser Pro Thr Arg Lys Val Pro Gly Phe 
65                  70                  75                  80  


Phe Gly Ala Ile Arg Tyr Leu His Arg Arg Leu Asp Leu Tyr Ala Asn 
                85                  90                  95      


Val Arg Pro Ala Lys Ser Arg Pro Ile Pro Gln Ser Arg Pro Gly Val 
            100                 105                 110         


Asp Leu Ile Ile Val His Glu Asn Thr Glu Gly Leu Tyr Val Glu Gln 
        115                 120                 125             


Glu Arg Arg Tyr Leu Asp Val Ala Ile Ala Asp Ala Val Ile Ser Lys 
    130                 135                 140                 


Lys Ala Ser Glu Arg Ile Gly Arg Val Ala Leu Lys Ile Ala Glu Gly 
145                 150                 155                 160 


Arg Pro Arg Lys Thr Leu His Ile Ala His Lys Ala Asn Val Leu Pro 
                165                 170                 175     


Val Thr Gln Gly Leu Phe Leu Asp Thr Val Lys Glu Ala Ala Arg Asp 
            180                 185                 190         


Phe Pro Leu Val Asn Val Gln Asp Ile Ile Val Asp Asn Cys Ala Met 
        195                 200                 205             


Gln Leu Val Met Arg Pro Glu Arg Phe Asp Val Ile Val Thr Thr Asn 
    210                 215                 220                 


Leu Leu Gly Asp Ile Leu Ser Asp Leu Thr Ala Gly Leu Val Gly Gly 
225                 230                 235                 240 


Leu Gly Leu Ala Pro Ser Ala Asn Ile Gly Asp Thr Thr Ala Val Phe 
                245                 250                 255     


Glu Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly Lys Gly Ile Ala 
            260                 265                 270         


Asn Pro Thr Ala Thr Ile Leu Ser Ala Ala Met Met Leu Asp Tyr Leu 
        275                 280                 285             


Gly Glu Arg Glu Val Ala Arg Lys Val Glu Arg Ala Val Asp Leu Val 
    290                 295                 300                 


Leu Glu Lys Gly Pro Arg Thr Pro Asp Leu Gly Gly Glu Ala Thr Thr 
305                 310                 315                 320 


Glu Thr Phe Thr Gln Ala Val Ile Glu Ala Leu Lys Ala Leu 
                325                 330                 


<210>  110
<211>  334
<212>  PRT
<213>  Thermus aquaticus

<400>  110

Met Ala Tyr Arg Ile Cys Leu Ile Glu Gly Asp Gly Ile Gly His Glu 
1               5                   10                  15      


Val Val Pro Ala Ala Arg Lys Val Leu Glu Ala Thr Gly Leu Pro Leu 
            20                  25                  30          


Glu Phe Val Glu Ala Glu Ala Gly Trp Glu Thr Phe Glu Arg Arg Gly 
        35                  40                  45              


Val Ser Val Pro Glu Glu Thr Val Glu Lys Ile Leu Ser Cys His Ala 
    50                  55                  60                  


Thr Leu Phe Gly Ala Ala Thr Ser Pro Thr Arg Lys Val Pro Gly Phe 
65                  70                  75                  80  


Phe Gly Ala Ile Arg Tyr Leu His Arg Arg Leu Asp Leu Tyr Ala Asn 
                85                  90                  95      


Val Arg Pro Ala Lys Ser Arg Pro Ile Pro Gln Ser Arg Pro Gly Val 
            100                 105                 110         


Asp Leu Ile Ile Val His Glu Asn Thr Glu Gly Leu Tyr Val Glu Gln 
        115                 120                 125             


Glu Arg Arg Tyr Leu Asp Val Ala Ile Ala Asp Ala Val Ile Ser Lys 
    130                 135                 140                 


Lys Ala Ser Glu Arg Ile Gly Arg Val Ala Leu Lys Ile Ala Glu Gly 
145                 150                 155                 160 


Arg Pro Arg Lys Thr Leu His Ile Ala His Lys Ala Asn Val Leu Pro 
                165                 170                 175     


Val Thr Gln Gly Leu Phe Leu Asp Thr Val Lys Glu Ala Ala Arg Asp 
            180                 185                 190         


Phe Pro Leu Val Asn Val Gln Asp Ile Ile Val Asp Asn Cys Ala Met 
        195                 200                 205             


Gln Leu Val Met Arg Pro Glu Arg Phe Asp Val Ile Val Thr Thr Asn 
    210                 215                 220                 


Leu Leu Gly Asp Ile Leu Ser Asp Leu Thr Ala Gly Leu Val Gly Gly 
225                 230                 235                 240 


Leu Gly Leu Ala Pro Ser Ala Asn Ile Gly Asp Thr Thr Ala Val Phe 
                245                 250                 255     


Glu Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly Lys Gly Ile Ala 
            260                 265                 270         


Asn Pro Thr Ala Thr Ile Leu Ser Ala Ala Met Met Leu Asp Tyr Leu 
        275                 280                 285             


Gly Glu Arg Glu Val Ala Arg Lys Val Glu Arg Ala Val Asp Leu Val 
    290                 295                 300                 


Leu Glu Lys Gly Pro Arg Thr Pro Asp Leu Gly Gly Glu Ala Thr Thr 
305                 310                 315                 320 


Glu Thr Phe Thr Gln Ala Val Ile Glu Ala Leu Lys Ala Leu 
                325                 330                 


<210>  111
<211>  334
<212>  PRT
<213>  Thermus sp. CCB US3 UF1

<400>  111

Met Ala Tyr Arg Ile Cys Leu Ile Glu Gly Asp Gly Ile Gly His Glu 
1               5                   10                  15      


Val Val Pro Ala Ala Arg Lys Val Leu Glu Ala Thr Gly Leu Pro Leu 
            20                  25                  30          


Glu Phe Val Glu Ala Glu Ala Gly Trp Glu Thr Phe Glu Arg Arg Gly 
        35                  40                  45              


Thr Ser Val Pro Glu Glu Thr Val Glu Lys Ile Leu Ser Ser His Ala 
    50                  55                  60                  


Thr Leu Phe Gly Ala Ala Thr Ser Pro Thr Arg Lys Val Pro Gly Phe 
65                  70                  75                  80  


Phe Gly Ala Ile Arg Tyr Leu His Arg Arg Leu Asp Leu Tyr Ala Asn 
                85                  90                  95      


Val Arg Pro Ala Lys Ser Arg Pro Ile Pro Gly Ser Arg Pro Gly Val 
            100                 105                 110         


Asp Leu Ile Ile Val His Glu Asn Thr Glu Gly Leu Tyr Val Glu Gln 
        115                 120                 125             


Glu Arg Arg Tyr Leu Asp Val Ala Ile Ala Asp Ala Val Ile Ser Lys 
    130                 135                 140                 


Lys Ala Ser Glu Arg Ile Gly Arg Val Ala Leu Lys Leu Ala Glu Ser 
145                 150                 155                 160 


Arg Pro Arg Lys Thr Leu His Ile Ala His Lys Ala Asn Val Leu Pro 
                165                 170                 175     


Val Thr Gln Gly Leu Phe Leu Asp Thr Val Arg Glu Val Ala Lys Glu 
            180                 185                 190         


Tyr Pro Leu Val Asn Val Gln Asp Ile Ile Val Asp Asn Cys Ala Met 
        195                 200                 205             


Gln Leu Val Met Arg Pro Glu Arg Phe Asp Val Val Val Thr Thr Asn 
    210                 215                 220                 


Leu Leu Gly Asp Ile Leu Ser Asp Leu Thr Ala Gly Leu Val Gly Gly 
225                 230                 235                 240 


Leu Gly Leu Ala Pro Ser Ala Asn Ile Gly Asp Thr Thr Ala Val Phe 
                245                 250                 255     


Glu Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly Lys Gly Ile Ala 
            260                 265                 270         


Asn Pro Thr Ala Thr Ile Leu Ser Ala Ala Met Met Leu Asp Tyr Leu 
        275                 280                 285             


Gly Glu Lys Glu Ala Ala Gln Arg Val Glu Lys Ala Val Asp Leu Val 
    290                 295                 300                 


Leu Glu Lys Gly Pro Arg Thr Pro Asp Leu Gly Gly Thr Ala Thr Thr 
305                 310                 315                 320 


Glu Thr Phe Thr Gln Ala Val Val Glu Ala Leu Gln Ala Leu 
                325                 330                 


<210>  112
<211>  334
<212>  PRT
<213>  Thermus thermophilus

<400>  112

Met Ala Tyr Arg Ile Cys Leu Ile Glu Gly Asp Gly Ile Gly His Glu 
1               5                   10                  15      


Val Ile Pro Ala Ala Arg Arg Val Leu Glu Ala Thr Gly Leu Pro Leu 
            20                  25                  30          


Glu Phe Val Glu Ala Glu Ala Gly Trp Glu Thr Phe Glu Arg Arg Gly 
        35                  40                  45              


Thr Ser Val Pro Glu Glu Thr Val Glu Lys Ile Leu Ser Cys His Ala 
    50                  55                  60                  


Thr Leu Phe Gly Ala Ala Thr Ser Pro Thr Arg Lys Val Pro Gly Phe 
65                  70                  75                  80  


Phe Gly Ala Ile Arg Tyr His Arg Arg Arg Leu Asp Leu Tyr Ala Asn 
                85                  90                  95      


Val Arg Pro Ala Lys Ser Arg Pro Val Pro Gly Ser Arg Pro Gly Val 
            100                 105                 110         


Asp Leu Val Ile Val His Glu Asn Thr Glu Gly Leu Tyr Val Glu Gln 
        115                 120                 125             


Glu Arg Arg Tyr Leu Asp Val Ala Ile Ala Asp Ala Val Ile Ser Lys 
    130                 135                 140                 


Lys Ala Ser Glu Arg Ile Gly Arg Ala Ala Leu Arg Ile Ala Glu Gly 
145                 150                 155                 160 


Arg Pro Arg Lys Thr Leu His Ile Ala His Lys Ala Asn Val Leu Pro 
                165                 170                 175     


Leu Thr Gln Gly Leu Phe Leu Asp Thr Val Lys Glu Val Ala Lys Asp 
            180                 185                 190         


Phe Pro Leu Val Asn Val Gln Asp Ile Ile Val Asp Asn Cys Ala Met 
        195                 200                 205             


Gln Leu Val Met Arg Pro Glu Arg Phe Asp Val Ile Val Thr Thr Asn 
    210                 215                 220                 


Leu Leu Gly Asp Ile Leu Ser Asp Leu Ala Ala Gly Leu Val Gly Gly 
225                 230                 235                 240 


Leu Gly Leu Ala Pro Ser Gly Asn Ile Gly Asp Thr Thr Ala Val Phe 
                245                 250                 255     


Glu Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly Lys Gly Ile Ala 
            260                 265                 270         


Asn Pro Thr Ala Ala Ile Leu Ser Ala Ala Met Met Leu Asp Tyr Leu 
        275                 280                 285             


Gly Glu Lys Glu Ala Ala Lys Arg Val Glu Lys Ala Val Asp Leu Val 
    290                 295                 300                 


Leu Glu Arg Gly Pro Arg Thr Pro Asp Leu Gly Gly Asp Ala Thr Thr 
305                 310                 315                 320 


Glu Ala Phe Thr Glu Ala Val Val Glu Ala Leu Lys Ser Leu 
                325                 330                 


<210>  113
<211>  334
<212>  PRT
<213>  Thermus thermophilus

<400>  113

Met Ala Tyr Arg Ile Cys Leu Ile Glu Gly Asp Gly Ile Gly His Glu 
1               5                   10                  15      


Val Ile Pro Ala Ala Arg Arg Val Leu Glu Ala Thr Gly Leu Pro Leu 
            20                  25                  30          


Glu Phe Val Glu Ala Glu Ala Gly Trp Glu Thr Phe Glu Arg Arg Gly 
        35                  40                  45              


Thr Ser Val Pro Glu Glu Thr Val Glu Lys Ile Leu Ser Cys His Ala 
    50                  55                  60                  


Thr Leu Phe Gly Ala Ala Thr Ser Pro Thr Arg Lys Val Pro Gly Phe 
65                  70                  75                  80  


Phe Gly Ala Ile Arg Tyr Leu His Arg Arg Leu Asp Leu Tyr Ala Asn 
                85                  90                  95      


Val Arg Pro Ala Lys Ser Arg Pro Val Pro Gly Ser Arg Pro Gly Val 
            100                 105                 110         


Asp Leu Val Ile Val His Glu Asn Thr Glu Gly Leu Tyr Val Glu Gln 
        115                 120                 125             


Glu Arg Arg Tyr Leu Asp Val Ala Ile Ala Asp Ala Val Ile Ser Lys 
    130                 135                 140                 


Lys Ala Ser Glu Arg Ile Gly Arg Ala Ala Leu Arg Ile Ala Glu Gly 
145                 150                 155                 160 


Arg Pro Arg Lys Thr Leu His Ile Ala His Lys Ala Asn Val Leu Pro 
                165                 170                 175     


Leu Thr Gln Gly Leu Phe Leu Asp Thr Val Lys Glu Val Ala Lys Asp 
            180                 185                 190         


Phe Pro Leu Val Asn Val Gln Asp Ile Ile Val Asp Asn Cys Ala Met 
        195                 200                 205             


Gln Leu Val Met Arg Pro Glu Arg Phe Asp Val Ile Val Thr Thr Asn 
    210                 215                 220                 


Leu Leu Gly Asp Ile Leu Ser Asp Leu Ala Ala Gly Leu Val Gly Gly 
225                 230                 235                 240 


Leu Gly Leu Ala Pro Ser Gly Asn Ile Gly Asp Thr Thr Ala Val Phe 
                245                 250                 255     


Glu Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly Lys Gly Ile Ala 
            260                 265                 270         


Asn Pro Thr Ala Ala Ile Leu Ser Ala Ala Met Met Leu Asp Tyr Leu 
        275                 280                 285             


Gly Glu Lys Glu Ala Ala Lys Arg Val Glu Lys Ala Val Asp Leu Val 
    290                 295                 300                 


Leu Glu Arg Gly Pro Arg Thr Pro Asp Leu Gly Gly Asp Ala Thr Thr 
305                 310                 315                 320 


Glu Ala Phe Thr Glu Ala Val Val Glu Ala Leu Lys Ser Leu 
                325                 330                 


<210>  114
<211>  334
<212>  PRT
<213>  Thermus thermophilus

<400>  114

Met Ala Tyr Arg Ile Cys Leu Ile Glu Gly Asp Gly Ile Gly His Glu 
1               5                   10                  15      


Val Ile Pro Ala Ala Arg Arg Val Leu Glu Ala Thr Gly Leu Pro Leu 
            20                  25                  30          


Glu Phe Val Glu Ala Glu Ala Gly Trp Glu Thr Phe Glu Arg Arg Gly 
        35                  40                  45              


Thr Ser Val Pro Glu Glu Thr Val Glu Lys Ile Leu Ser Cys His Ala 
    50                  55                  60                  


Thr Leu Phe Gly Ala Ala Thr Ser Pro Thr Arg Lys Val Pro Gly Phe 
65                  70                  75                  80  


Phe Gly Ala Ile Arg Tyr Leu His Arg Arg Leu Asp Leu Tyr Ala Asn 
                85                  90                  95      


Val Arg Pro Ala Lys Ser Arg Pro Val Pro Gly Ser Arg Pro Gly Val 
            100                 105                 110         


Asp Leu Val Ile Val His Glu Asn Thr Glu Gly Leu Tyr Val Glu Gln 
        115                 120                 125             


Glu Arg Arg Tyr Leu Asp Val Ala Ile Ala Asp Ala Val Ile Ser Lys 
    130                 135                 140                 


Lys Ala Ser Glu Arg Ile Gly Arg Ala Ala Leu Arg Ile Ala Glu Gly 
145                 150                 155                 160 


Arg Pro Arg Lys Thr Leu His Ile Ala His Lys Ala Asn Val Leu Pro 
                165                 170                 175     


Leu Thr Gln Gly Leu Phe Leu Asp Thr Val Lys Glu Val Ala Lys Asp 
            180                 185                 190         


Phe Pro Leu Val Asn Val Gln Asp Ile Ile Val Asp Asn Cys Ala Met 
        195                 200                 205             


Gln Leu Val Met Arg Pro Glu Arg Phe Asp Val Ile Val Thr Thr Asn 
    210                 215                 220                 


Leu Leu Gly Asp Ile Leu Ser Asp Leu Ala Ala Gly Leu Val Gly Gly 
225                 230                 235                 240 


Leu Gly Leu Ala Pro Ser Gly Asn Ile Gly Asp Thr Thr Ala Val Phe 
                245                 250                 255     


Glu Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly Lys Gly Ile Ala 
            260                 265                 270         


Asn Pro Thr Ala Ala Ile Leu Ser Ala Ala Met Met Leu Asp Tyr Leu 
        275                 280                 285             


Gly Glu Lys Glu Ala Ala Lys Arg Val Glu Lys Ala Val Asp Leu Val 
    290                 295                 300                 


Leu Glu Arg Gly Pro Arg Thr Pro Asp Leu Gly Gly Asp Ala Thr Thr 
305                 310                 315                 320 


Glu Ala Phe Thr Glu Ala Val Val Glu Ala Leu Lys Ser Leu 
                325                 330                 


<210>  115
<211>  334
<212>  PRT
<213>  Thermus thermophilus

<400>  115

Met Ala Tyr Arg Ile Cys Leu Ile Glu Gly Asp Gly Ile Gly His Glu 
1               5                   10                  15      


Val Ile Pro Ala Ala Arg Arg Val Leu Glu Ala Thr Gly Leu Pro Leu 
            20                  25                  30          


Glu Phe Val Glu Ala Glu Ala Gly Trp Glu Thr Phe Glu Arg Arg Gly 
        35                  40                  45              


Thr Ser Val Pro Glu Glu Thr Val Glu Lys Ile Leu Ser Cys His Ala 
    50                  55                  60                  


Thr Leu Phe Gly Ala Ala Thr Ser Pro Thr Arg Lys Val Pro Gly Phe 
65                  70                  75                  80  


Phe Gly Ala Ile Arg Tyr Leu His Arg Arg Leu Asp Leu Tyr Ala Asn 
                85                  90                  95      


Val Arg Pro Ala Lys Ser Arg Pro Val Pro Gly Ser Arg Pro Gly Val 
            100                 105                 110         


Asp Leu Val Ile Val His Glu Asn Thr Glu Gly Leu Tyr Val Glu Gln 
        115                 120                 125             


Glu Arg Arg Tyr Leu Asp Val Ala Ile Ala Asp Ala Val Ile Ser Lys 
    130                 135                 140                 


Lys Ala Ser Glu Arg Ile Gly Arg Ala Ala Leu Arg Ile Ala Glu Gly 
145                 150                 155                 160 


Arg Pro Arg Lys Thr Leu His Ile Ala His Lys Ala Asn Val Leu Pro 
                165                 170                 175     


Leu Thr Gln Gly Leu Phe Leu Asp Thr Val Lys Glu Val Ala Lys Asp 
            180                 185                 190         


Phe Pro Leu Val Asn Val Gln Asp Ile Ile Val Asp Asn Cys Ala Met 
        195                 200                 205             


Gln Leu Val Met Arg Pro Glu Arg Phe Asp Val Ile Val Thr Thr Asn 
    210                 215                 220                 


Leu Leu Gly Asp Ile Leu Ser Asp Leu Ala Ala Gly Leu Val Gly Gly 
225                 230                 235                 240 


Leu Gly Leu Ala Pro Ser Gly Asn Ile Gly Asp Thr Thr Ala Val Phe 
                245                 250                 255     


Glu Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly Lys Gly Ile Ala 
            260                 265                 270         


Asn Pro Thr Ala Ala Ile Leu Ser Ala Ala Met Met Leu Asp Tyr Leu 
        275                 280                 285             


Gly Glu Lys Glu Ala Ala Lys Arg Val Glu Lys Ala Val Asp Leu Val 
    290                 295                 300                 


Leu Glu Arg Gly Pro Arg Thr Pro Asp Leu Gly Gly Asp Ala Thr Thr 
305                 310                 315                 320 


Glu Ala Phe Thr Glu Ala Val Val Glu Ala Leu Lys Ser Leu 
                325                 330                 


<210>  116
<211>  334
<212>  PRT
<213>  Thermus thermophilus

<400>  116

Met Ala Tyr Arg Ile Cys Leu Ile Glu Gly Asp Gly Ile Gly His Glu 
1               5                   10                  15      


Val Ile Pro Ala Ala Arg Arg Val Leu Glu Ala Thr Gly Leu Pro Leu 
            20                  25                  30          


Glu Phe Val Glu Ala Glu Ala Gly Trp Glu Thr Phe Glu Arg Arg Gly 
        35                  40                  45              


Thr Ser Val Pro Glu Glu Thr Val Glu Lys Ile Leu Ser Cys His Ala 
    50                  55                  60                  


Thr Leu Phe Gly Ala Ala Thr Ser Pro Thr Arg Lys Val Pro Gly Phe 
65                  70                  75                  80  


Phe Gly Ala Ile Arg Tyr Leu His Arg Arg Leu Asp Leu Tyr Ala Asn 
                85                  90                  95      


Val Arg Pro Ala Lys Ser Arg Pro Val Pro Gly Ser Arg Pro Gly Val 
            100                 105                 110         


Asp Leu Val Ile Val His Glu Asn Thr Glu Gly Leu Tyr Val Glu Gln 
        115                 120                 125             


Glu Arg Arg Tyr Leu Asp Val Ala Ile Ala Asp Ala Val Ile Ser Lys 
    130                 135                 140                 


Lys Ala Ser Glu Arg Ile Gly Arg Ala Ala Leu Arg Ile Ala Glu Gly 
145                 150                 155                 160 


Arg Pro Arg Lys Thr Leu His Ile Ala His Lys Ala Asn Val Leu Pro 
                165                 170                 175     


Leu Thr Gln Gly Leu Phe Leu Asp Thr Val Lys Glu Val Ala Lys Asp 
            180                 185                 190         


Phe Pro Leu Val Asn Val Gln Asp Ile Ile Val Asp Asn Cys Ala Met 
        195                 200                 205             


Gln Leu Val Met Arg Pro Glu Arg Phe Asp Val Ile Val Thr Thr Asn 
    210                 215                 220                 


Leu Leu Gly Asp Ile Leu Ser Asp Leu Ala Ala Gly Leu Val Gly Gly 
225                 230                 235                 240 


Leu Gly Leu Ala Pro Ser Gly Asn Ile Gly Asp Thr Thr Ala Val Phe 
                245                 250                 255     


Glu Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly Lys Gly Ile Ala 
            260                 265                 270         


Asn Pro Thr Ala Ala Ile Leu Ser Ala Ala Met Met Leu Asp Tyr Leu 
        275                 280                 285             


Gly Glu Lys Glu Ala Ala Lys Arg Val Glu Lys Ala Val Asp Leu Val 
    290                 295                 300                 


Leu Glu Arg Gly Pro Arg Thr Pro Asp Leu Gly Gly Asp Ala Thr Thr 
305                 310                 315                 320 


Glu Ala Phe Thr Glu Ala Val Val Glu Ala Leu Lys Ser Leu 
                325                 330                 


<210>  117
<211>  333
<212>  PRT
<213>  Thermus thermophilus

<400>  117

Ala Tyr Arg Ile Cys Leu Ile Glu Gly Asp Gly Ile Gly His Glu Val 
1               5                   10                  15      


Ile Pro Ala Ala Arg Arg Val Leu Glu Ala Thr Gly Leu Pro Leu Glu 
            20                  25                  30          


Phe Val Glu Ala Glu Ala Gly Trp Glu Thr Phe Glu Arg Arg Gly Thr 
        35                  40                  45              


Ser Val Pro Glu Glu Thr Val Glu Lys Ile Leu Ser Cys His Ala Thr 
    50                  55                  60                  


Leu Phe Gly Ala Ala Thr Ser Pro Thr Arg Lys Val Pro Gly Phe Phe 
65                  70                  75                  80  


Gly Ala Ile Arg Tyr Leu His Arg Arg Leu Asp Leu Tyr Ala Asn Val 
                85                  90                  95      


Arg Pro Ala Lys Ser Arg Pro Val Pro Gly Ser Arg Pro Gly Val Asp 
            100                 105                 110         


Leu Val Ile Val His Glu Asn Thr Glu Gly Leu Tyr Val Glu Gln Glu 
        115                 120                 125             


Arg Arg Tyr Leu Asp Val Ala Ile Ala Asp Ala Val Ile Ser Lys Lys 
    130                 135                 140                 


Ala Ser Glu Arg Ile Gly Arg Ala Ala Leu Arg Ile Ala Glu Gly Arg 
145                 150                 155                 160 


Pro Arg Lys Thr Leu His Ile Ala His Lys Ala Asn Val Leu Pro Leu 
                165                 170                 175     


Thr Gln Gly Leu Phe Leu Asp Thr Val Lys Glu Val Ala Lys Asp Phe 
            180                 185                 190         


Pro Leu Val Asn Val Gln Asp Ile Ile Val Asp Asn Cys Ala Met Gln 
        195                 200                 205             


Leu Val Met Arg Pro Glu Arg Phe Asp Val Ile Val Thr Thr Asn Leu 
    210                 215                 220                 


Leu Gly Asp Ile Leu Ser Asp Leu Ala Ala Gly Leu Val Gly Gly Leu 
225                 230                 235                 240 


Gly Leu Ala Pro Ser Gly Asn Ile Gly Asp Thr Thr Ala Val Phe Glu 
                245                 250                 255     


Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly Lys Gly Ile Ala Asn 
            260                 265                 270         


Pro Thr Ala Ala Ile Leu Ser Ala Ala Met Met Leu Asp Tyr Leu Gly 
        275                 280                 285             


Glu Lys Glu Ala Ala Lys Arg Val Glu Lys Ala Val Asp Leu Val Leu 
    290                 295                 300                 


Glu Arg Gly Pro Arg Thr Pro Asp Leu Gly Gly Asp Ala Thr Thr Glu 
305                 310                 315                 320 


Ala Phe Thr Glu Ala Val Val Glu Ala Leu Lys Ser Leu 
                325                 330             


<210>  118
<211>  333
<212>  PRT
<213>  Thermus thermophilus

<400>  118

Ala Tyr Arg Ile Cys Leu Ile Glu Gly Asp Gly Ile Gly His Glu Val 
1               5                   10                  15      


Ile Pro Ala Ala Arg Arg Val Leu Glu Ala Thr Gly Leu Pro Leu Glu 
            20                  25                  30          


Phe Val Glu Ala Glu Ala Gly Trp Glu Thr Phe Glu Arg Arg Gly Thr 
        35                  40                  45              


Ser Val Pro Glu Glu Thr Val Glu Lys Ile Leu Ser Cys His Ala Thr 
    50                  55                  60                  


Leu Phe Gly Ala Ala Thr Ser Pro Thr Arg Lys Val Pro Gly Phe Phe 
65                  70                  75                  80  


Gly Ala Ile Arg Tyr Leu His Arg Arg Leu Asp Leu Tyr Ala Asn Val 
                85                  90                  95      


Arg Pro Ala Lys Ser Arg Pro Val Pro Gly Ser Arg Pro Gly Val Asp 
            100                 105                 110         


Leu Val Ile Val His Glu Asn Thr Glu Gly Leu Tyr Val Glu Gln Glu 
        115                 120                 125             


Arg Arg Tyr Leu Asp Val Ala Ile Ala Asp Ala Val Ile Ser Lys Lys 
    130                 135                 140                 


Ala Ser Glu Arg Ile Gly Arg Ala Ala Leu Arg Ile Ala Glu Gly Arg 
145                 150                 155                 160 


Pro Arg Lys Thr Leu His Ile Ala His Lys Ala Asn Val Leu Pro Leu 
                165                 170                 175     


Thr Gln Gly Leu Phe Leu Asp Thr Val Lys Glu Val Ala Lys Asp Phe 
            180                 185                 190         


Pro Leu Val Asn Val Gln Asp Ile Ile Val Asp Asn Cys Ala Met Gln 
        195                 200                 205             


Leu Val Met Arg Pro Glu Arg Phe Asp Val Ile Val Thr Thr Asn Leu 
    210                 215                 220                 


Leu Gly Asp Ile Leu Ser Asp Leu Ala Ala Gly Leu Val Gly Gly Leu 
225                 230                 235                 240 


Gly Leu Ala Pro Ser Gly Asn Ile Gly Asp Thr Thr Ala Val Phe Glu 
                245                 250                 255     


Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly Lys Gly Ile Ala Asn 
            260                 265                 270         


Pro Thr Ala Ala Ile Leu Ser Ala Ala Met Met Leu Asp Tyr Leu Gly 
        275                 280                 285             


Glu Lys Glu Ala Ala Lys Arg Val Glu Lys Ala Val Asp Leu Val Leu 
    290                 295                 300                 


Glu Arg Gly Pro Arg Thr Pro Asp Leu Gly Gly Asp Ala Thr Thr Glu 
305                 310                 315                 320 


Ala Phe Thr Glu Ala Val Val Glu Ala Leu Lys Ser Leu 
                325                 330             


<210>  119
<211>  334
<212>  PRT
<213>  Thermus thermophilus

<400>  119

Met Ala Tyr Arg Ile Cys Leu Ile Glu Gly Asp Gly Ile Gly His Glu 
1               5                   10                  15      


Val Ile Pro Ala Ala Arg Arg Val Leu Glu Ala Thr Gly Leu Pro Leu 
            20                  25                  30          


Glu Phe Val Glu Ala Glu Ala Gly Trp Glu Thr Phe Glu Arg Arg Gly 
        35                  40                  45              


Thr Ser Val Pro Glu Glu Thr Val Glu Lys Ile Leu Ser Cys His Ala 
    50                  55                  60                  


Thr Leu Phe Gly Ala Ala Thr Ser Pro Thr Arg Lys Val Pro Gly Phe 
65                  70                  75                  80  


Phe Gly Ala Ile Arg Tyr Leu His Arg Arg Leu Asp Leu Tyr Ala Asn 
                85                  90                  95      


Val Arg Pro Ala Lys Ser Arg Pro Val Pro Gly Ser Arg Pro Gly Val 
            100                 105                 110         


Asp Leu Val Ile Val His Glu Asn Thr Glu Gly Leu Tyr Val Glu Gln 
        115                 120                 125             


Glu Arg Arg Tyr Leu Asp Val Ala Ile Ala Asp Ala Val Ile Ser Lys 
    130                 135                 140                 


Lys Ala Ser Glu Arg Ile Gly Arg Ala Ala Leu Arg Ile Ala Glu Gly 
145                 150                 155                 160 


Arg Pro Arg Lys Thr Leu His Ile Ala His Lys Ala Asn Val Leu Pro 
                165                 170                 175     


Leu Thr Gln Gly Leu Phe Leu Asp Thr Val Lys Glu Val Ala Lys Asp 
            180                 185                 190         


Phe Pro Leu Val Asn Val Gln Asp Ile Ile Val Asp Asn Cys Ala Met 
        195                 200                 205             


Gln Leu Val Met Arg Pro Glu Arg Phe Asp Val Ile Val Thr Thr Asn 
    210                 215                 220                 


Leu Leu Gly Asp Ile Leu Ser Asp Leu Ala Ala Gly Leu Val Gly Gly 
225                 230                 235                 240 


Leu Gly Leu Ala Pro Ser Gly Asn Ile Gly Asp Thr Thr Ala Val Phe 
                245                 250                 255     


Glu Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly Lys Gly Ile Ala 
            260                 265                 270         


Asn Pro Thr Ala Ala Ile Leu Ser Ala Ala Met Met Leu Asp Tyr Leu 
        275                 280                 285             


Gly Glu Lys Glu Ala Ala Lys Arg Val Glu Lys Ala Val Asp Leu Val 
    290                 295                 300                 


Leu Glu Arg Gly Pro Arg Thr Pro Asp Leu Gly Gly Asp Ala Thr Thr 
305                 310                 315                 320 


Glu Ala Phe Thr Glu Ala Val Val Glu Ala Leu Lys Ser Leu 
                325                 330                 


<210>  120
<211>  334
<212>  PRT
<213>  Thermus thermophilus

<400>  120

Met Ala Tyr Arg Ile Cys Leu Ile Glu Gly Asp Gly Ile Gly His Glu 
1               5                   10                  15      


Val Ile Pro Ala Ala Arg Arg Val Leu Glu Ala Thr Gly Leu Pro Leu 
            20                  25                  30          


Glu Phe Val Glu Ala Glu Ala Gly Trp Glu Thr Phe Glu Arg Arg Gly 
        35                  40                  45              


Thr Ser Val Pro Glu Glu Thr Val Glu Lys Ile Leu Ser Cys His Ala 
    50                  55                  60                  


Thr Leu Phe Gly Ala Ala Thr Ser Pro Thr Arg Lys Val Pro Gly Phe 
65                  70                  75                  80  


Phe Gly Ala Ile Arg Tyr Leu His Arg Arg Leu Asp Leu Tyr Ala Asn 
                85                  90                  95      


Val Arg Pro Ala Lys Ser Arg Pro Val Pro Gly Ser Arg Pro Gly Val 
            100                 105                 110         


Asp Leu Val Ile Val His Glu Asn Thr Glu Gly Leu Tyr Val Glu Gln 
        115                 120                 125             


Glu Arg Arg Tyr Leu Asp Val Ala Ile Ala Asp Ala Val Ile Ser Lys 
    130                 135                 140                 


Lys Ala Ser Glu Arg Ile Gly Arg Ala Ala Leu Arg Ile Ala Glu Gly 
145                 150                 155                 160 


Arg Pro Arg Lys Thr Leu His Ile Ala His Lys Ala Asn Val Leu Pro 
                165                 170                 175     


Leu Thr Gln Gly Leu Phe Leu Asp Thr Val Lys Glu Val Ala Lys Asp 
            180                 185                 190         


Phe Pro Leu Val Asn Val Gln Asp Ile Ile Val Asp Asn Cys Ala Met 
        195                 200                 205             


Gln Leu Val Met Arg Pro Glu Arg Phe Asp Val Ile Val Thr Thr Asn 
    210                 215                 220                 


Leu Leu Gly Asp Ile Leu Ser Asp Leu Ala Ala Gly Leu Val Gly Gly 
225                 230                 235                 240 


Leu Gly Leu Ala Pro Ser Gly Asn Ile Gly Asp Thr Thr Ala Val Phe 
                245                 250                 255     


Glu Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly Lys Gly Ile Ala 
            260                 265                 270         


Asn Pro Thr Ala Ala Ile Leu Ser Ala Ala Met Met Leu Asp Tyr Leu 
        275                 280                 285             


Gly Glu Lys Glu Ala Ala Lys Arg Val Glu Lys Ala Val Asp Leu Val 
    290                 295                 300                 


Leu Glu Arg Gly Pro Arg Thr Pro Asp Leu Gly Gly Asp Ala Thr Thr 
305                 310                 315                 320 


Glu Ala Phe Thr Glu Ala Val Val Glu Ala Leu Lys Ser Leu 
                325                 330                 


<210>  121
<211>  345
<212>  PRT
<213>  Thermus thermophilus

<400>  121

Met Lys Val Ala Val Leu Pro Gly Asp Gly Ile Gly Pro Glu Val Thr 
1               5                   10                  15      


Glu Ala Ala Leu Lys Val Leu Arg Ala Leu Asp Glu Ala Glu Gly Leu 
            20                  25                  30          


Gly Leu Ala Tyr Glu Val Phe Pro Phe Gly Gly Ala Ala Ile Asp Ala 
        35                  40                  45              


Phe Gly Glu Pro Phe Pro Glu Pro Thr Arg Lys Gly Val Glu Glu Ala 
    50                  55                  60                  


Glu Ala Val Leu Leu Gly Ser Val Gly Gly Pro Lys Trp Asp Gly Leu 
65                  70                  75                  80  


Pro Arg Lys Ile Arg Pro Glu Thr Gly Leu Leu Ser Leu His Lys Ser 
                85                  90                  95      


Gln Asp Leu Phe Ala Asn Leu Arg Pro Ala Lys Val Phe Pro Gly Leu 
            100                 105                 110         


Glu Arg Leu Ser Pro Leu Lys Glu Glu Ile Ala Arg Gly Val Asp Val 
        115                 120                 125             


Leu Ile Val His Glu Leu Thr Gly Gly Ile Tyr Phe Gly Glu Pro Arg 
    130                 135                 140                 


Gly Met Ser Glu Ala Glu Ala Trp Asn Thr Glu Arg Tyr Ser Lys Pro 
145                 150                 155                 160 


Glu Val Glu Arg Val Ala Arg Val Ala Phe Glu Ala Ala Arg Lys Arg 
                165                 170                 175     


Arg Lys His Val Val Ser Val Asp Lys Ala Asn Val Leu Glu Val Gly 
            180                 185                 190         


Glu Phe Trp Arg Lys Thr Val Glu Glu Val Gly Arg Gly Tyr Pro Asp 
        195                 200                 205             


Val Ala Leu Glu His Gln Tyr Val Asp Ala Met Ala Met His Leu Val 
    210                 215                 220                 


Arg Ser Pro Ala Arg Phe Asp Val Val Val Thr Gly Asn Ile Phe Gly 
225                 230                 235                 240 


Asp Ile Leu Ser Asp Leu Ala Ser Val Leu Pro Gly Ser Leu Gly Leu 
                245                 250                 255     


Leu Pro Ser Ala Ser Leu Gly Arg Gly Thr Pro Val Phe Glu Pro Val 
            260                 265                 270         


His Gly Ser Ala Pro Asp Ile Ala Gly Lys Gly Leu Ala Asn Pro Thr 
        275                 280                 285             


Ala Ala Ile Leu Ser Ala Ala Met Met Leu Glu His Ala Phe Gly Leu 
    290                 295                 300                 


Val Glu Leu Ala Arg Lys Val Glu Asp Ala Val Ala Lys Ala Leu Leu 
305                 310                 315                 320 


Glu Ala Pro Pro Pro Asp Leu Gly Gly Ser Ala Gly Thr Glu Ala Phe 
                325                 330                 335     


Thr Ala Thr Val Leu Arg His Leu Ala 
            340                 345 


<210>  122
<211>  496
<212>  PRT
<213>  Thermus thermophilus

<400>  122

Met Pro Leu Ile Thr Thr Glu Thr Gly Lys Lys Met His Val Leu Glu 
1               5                   10                  15      


Asp Gly Arg Lys Leu Ile Thr Val Ile Pro Gly Asp Gly Val Gly Pro 
            20                  25                  30          


Glu Cys Val Glu Ala Thr Leu Lys Val Leu Glu Ala Ala Lys Ala Pro 
        35                  40                  45              


Leu Ala Tyr Glu Val Arg Glu Ala Gly Ala Ser Val Phe Arg Arg Gly 
    50                  55                  60                  


Ile Ala Ser Gly Val Pro Gln Glu Thr Ile Glu Ser Ile Arg Lys Thr 
65                  70                  75                  80  


Arg Val Val Leu Lys Gly Pro Leu Glu Thr Pro Val Gly Tyr Gly Glu 
                85                  90                  95      


Lys Ser Ala Asn Val Thr Leu His Lys Leu Phe Glu Thr Tyr Ala Asn 
            100                 105                 110         


Val Arg Pro Val Arg Glu Phe Pro Asn Val Pro Thr Pro Tyr Ala Gly 
        115                 120                 125             


Arg Gly Ile Asp Leu Val Val Val His Glu Asn Val Glu Asp Leu Tyr 
    130                 135                 140                 


Ala Gly Ile Glu His Met Gln Thr Pro Ser Val Ala Gln Thr Leu Lys 
145                 150                 155                 160 


Leu Ile Ser Trp Lys Gly Ser Glu Lys Ile Val Arg Phe Ala Phe Glu 
                165                 170                 175     


Leu Ala Arg Ala Glu Gly Arg Lys Lys Val His Cys Ala Thr Lys Ser 
            180                 185                 190         


Asn Ile Met Lys Leu Ala Glu Gly Thr Leu Lys Arg Ala Phe Glu Gln 
        195                 200                 205             


Val Ala Gln Glu Tyr Pro Asp Ile Glu Ala Val His Ile Ile Val Asp 
    210                 215                 220                 


Asn Ala Ala His Gln Leu Val Lys Arg Pro Glu Gln Phe Glu Val Ile 
225                 230                 235                 240 


Val Thr Thr Asn Met Asn Gly Asp Ile Leu Ser Asp Leu Thr Ser Gly 
                245                 250                 255     


Leu Ile Gly Gly Leu Gly Phe Ala Pro Ser Ala Asn Ile Gly Asn Glu 
            260                 265                 270         


Val Ala Ile Phe Glu Ala Val His Gly Ser Ala Pro Lys Tyr Ala Gly 
        275                 280                 285             


Lys Asn Val Ile Asn Pro Thr Ala Val Leu Leu Ser Ala Val Met Met 
    290                 295                 300                 


Leu Arg Tyr Leu Glu Glu Phe Ala Thr Ala Asp Leu Ile Glu Asn Ala 
305                 310                 315                 320 


Leu Leu Tyr Thr Leu Glu Glu Gly Arg Val Leu Thr Gly Asp Val Val 
                325                 330                 335     


Gly Tyr Asp Arg Gly Ala Lys Thr Thr Glu Tyr Thr Glu Ala Ile Ile 
            340                 345                 350         


Gln Asn Leu Gly Lys Thr Pro Arg Lys Thr Gln Val Arg Gly Tyr Lys 
        355                 360                 365             


Pro Phe Arg Leu Pro Gln Val Asp Gly Ala Ile Ala Pro Ile Val Pro 
    370                 375                 380                 


Arg Ser Arg Arg Val Val Gly Val Asp Val Phe Val Glu Thr Asn Leu 
385                 390                 395                 400 


Leu Pro Glu Ala Leu Gly Lys Ala Leu Glu Asp Leu Ala Ala Gly Thr 
                405                 410                 415     


Pro Phe Arg Leu Lys Met Ile Ser Asn Arg Gly Thr Gln Val Tyr Pro 
            420                 425                 430         


Pro Thr Gly Gly Leu Thr Asp Leu Val Asp His Tyr Arg Cys Arg Phe 
        435                 440                 445             


Leu Tyr Thr Gly Glu Gly Glu Ala Lys Asp Pro Glu Ile Leu Asp Leu 
    450                 455                 460                 


Val Ser Arg Val Ala Ser Arg Phe Arg Trp Met His Leu Glu Lys Leu 
465                 470                 475                 480 


Gln Glu Phe Asp Gly Glu Pro Gly Phe Thr Lys Ala Gln Gly Glu Asp 
                485                 490                 495     


<210>  123
<211>  334
<212>  PRT
<213>  Thermus thermophilus

<400>  123

Met Ala Tyr Arg Ile Cys Leu Ile Glu Gly Asp Gly Ile Gly His Glu 
1               5                   10                  15      


Val Ile Pro Ala Ala Arg Arg Val Leu Glu Ala Thr Gly Leu Pro Leu 
            20                  25                  30          


Glu Phe Val Glu Ala Glu Ala Gly Trp Glu Thr Phe Glu Arg Arg Gly 
        35                  40                  45              


Thr Ser Val Pro Glu Glu Thr Val Glu Lys Ile Leu Ser Cys His Ala 
    50                  55                  60                  


Thr Leu Phe Gly Ala Ala Thr Ser Pro Thr Arg Lys Val Pro Gly Phe 
65                  70                  75                  80  


Phe Gly Ala Ile Arg Tyr Leu His Arg Arg Leu Asp Leu Tyr Ala Asn 
                85                  90                  95      


Val Arg Pro Ala Lys Ser Arg Pro Val Pro Gly Ser Arg Pro Gly Val 
            100                 105                 110         


Asp Leu Val Ile Val His Glu Asn Thr Glu Gly Leu Tyr Val Glu Gln 
        115                 120                 125             


Glu Arg Arg Tyr Leu Asp Val Ala Ile Ala Asp Ala Val Ile Ser Lys 
    130                 135                 140                 


Lys Ala Ser Glu Arg Ile Gly Arg Ala Ala Leu Arg Ile Ala Glu Gly 
145                 150                 155                 160 


Arg Pro Arg Lys Thr Leu His Ile Ala His Lys Ala Asn Val Leu Pro 
                165                 170                 175     


Leu Thr Gln Gly Leu Phe Leu Asp Thr Val Lys Glu Val Ala Lys Asp 
            180                 185                 190         


Phe Pro Leu Val Asn Val Gln Asp Ile Ile Val Asp Asn Cys Ala Met 
        195                 200                 205             


Gln Leu Val Met Arg Pro Glu Arg Phe Asp Val Ile Val Thr Thr Asn 
    210                 215                 220                 


Leu Leu Gly Asp Ile Leu Ser Asp Leu Ala Ala Gly Leu Val Gly Gly 
225                 230                 235                 240 


Leu Gly Leu Ala Pro Ser Gly Asn Ile Gly Asp Thr Thr Ala Val Phe 
                245                 250                 255     


Glu Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly Lys Gly Ile Ala 
            260                 265                 270         


Asn Pro Thr Ala Ala Ile Leu Ser Ala Ala Met Met Leu Asp Tyr Leu 
        275                 280                 285             


Gly Glu Lys Glu Ala Ala Lys Arg Val Glu Lys Ala Val Asp Leu Val 
    290                 295                 300                 


Leu Glu Arg Gly Pro Arg Thr Pro Asp Leu Gly Gly Asp Ala Thr Thr 
305                 310                 315                 320 


Glu Ala Phe Thr Glu Ala Val Val Glu Ala Leu Lys Ser Leu 
                325                 330                 


<210>  124
<211>  334
<212>  PRT
<213>  Thermus thermophilus

<400>  124

Met Ala Tyr Arg Ile Cys Leu Ile Glu Gly Asp Gly Ile Gly His Glu 
1               5                   10                  15      


Val Ile Pro Ala Ala Arg Arg Val Leu Glu Ala Thr Gly Leu Pro Leu 
            20                  25                  30          


Glu Phe Val Glu Ala Glu Ala Gly Trp Glu Thr Phe Glu Arg Arg Gly 
        35                  40                  45              


Thr Ser Val Pro Glu Glu Thr Val Glu Lys Ile Leu Ser Cys His Ala 
    50                  55                  60                  


Thr Leu Phe Gly Ala Ala Thr Ser Pro Thr Arg Lys Val Pro Gly Phe 
65                  70                  75                  80  


Phe Gly Ala Ile Arg Tyr Leu His Arg Arg Leu Asp Leu Tyr Ala Asn 
                85                  90                  95      


Val Arg Pro Ala Lys Ser Arg Pro Val Pro Gly Ser Arg Pro Gly Val 
            100                 105                 110         


Asp Leu Val Ile Val His Glu Asn Thr Glu Gly Leu Tyr Val Glu Gln 
        115                 120                 125             


Glu Arg Arg Tyr Leu Asp Val Ala Ile Ala Asp Ala Val Ile Ser Lys 
    130                 135                 140                 


Lys Ala Ser Glu Arg Ile Gly Arg Ala Ala Leu Arg Ile Ala Glu Gly 
145                 150                 155                 160 


Arg Pro Arg Lys Thr Leu His Ile Ala His Lys Ala Asn Val Leu Pro 
                165                 170                 175     


Leu Thr Gln Gly Leu Phe Leu Asp Thr Val Lys Glu Val Ala Lys Asp 
            180                 185                 190         


Phe Pro Leu Val Asn Val Gln Asp Ile Ile Val Asp Asn Cys Ala Met 
        195                 200                 205             


Gln Leu Val Met Arg Pro Glu Arg Phe Asp Val Ile Val Thr Thr Asn 
    210                 215                 220                 


Leu Leu Gly Asp Ile Leu Ser Asp Leu Ala Ala Gly Leu Val Gly Gly 
225                 230                 235                 240 


Leu Gly Leu Ala Pro Ser Gly Asn Ile Gly Asp Thr Thr Ala Val Phe 
                245                 250                 255     


Glu Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly Lys Gly Ile Ala 
            260                 265                 270         


Asn Pro Thr Ala Ala Ile Leu Ser Ala Ala Met Met Leu Asp Tyr Leu 
        275                 280                 285             


Gly Glu Lys Glu Ala Ala Lys Arg Val Glu Lys Ala Val Asp Leu Val 
    290                 295                 300                 


Leu Glu Arg Gly Pro Arg Thr Pro Asp Leu Gly Gly Asp Ala Thr Thr 
305                 310                 315                 320 


Glu Ala Phe Thr Glu Ala Val Val Glu Ala Leu Lys Ser Leu 
                325                 330                 


<210>  125
<211>  334
<212>  PRT
<213>  Thermus thermophilus

<400>  125

Met Ala Tyr Arg Ile Cys Leu Ile Glu Gly Asp Gly Ile Gly His Glu 
1               5                   10                  15      


Val Ile Pro Ala Ala Arg Arg Val Leu Glu Ala Thr Gly Leu Pro Leu 
            20                  25                  30          


Glu Phe Val Glu Ala Glu Ala Gly Trp Glu Thr Phe Glu Arg Arg Gly 
        35                  40                  45              


Thr Ser Val Pro Glu Glu Thr Val Glu Lys Ile Leu Ser Cys His Ala 
    50                  55                  60                  


Thr Leu Phe Gly Ala Ala Thr Ser Pro Thr Arg Lys Val Pro Gly Phe 
65                  70                  75                  80  


Phe Gly Ala Ile Arg Tyr Leu His Arg Arg Leu Asp Leu Tyr Ala Asn 
                85                  90                  95      


Val Arg Pro Ala Lys Ser Arg Pro Val Pro Gly Ser Arg Pro Gly Val 
            100                 105                 110         


Asp Leu Val Ile Val His Glu Asn Thr Glu Gly Leu Tyr Val Glu Gln 
        115                 120                 125             


Glu Arg Arg Tyr Leu Asp Val Ala Ile Ala Asp Ala Val Ile Ser Lys 
    130                 135                 140                 


Lys Ala Ser Glu Arg Ile Gly Arg Ala Ala Leu Arg Ile Ala Glu Gly 
145                 150                 155                 160 


Arg Pro Arg Lys Thr Leu His Ile Ala His Lys Ala Asn Val Leu Pro 
                165                 170                 175     


Leu Thr Gln Gly Leu Phe Leu Asp Thr Val Lys Glu Val Ala Lys Asp 
            180                 185                 190         


Phe Pro Leu Val Asn Val Gln Asp Ile Ile Val Asp Asn Cys Ala Met 
        195                 200                 205             


Gln Leu Val Met Arg Pro Glu Arg Phe Asp Val Ile Val Thr Thr Asn 
    210                 215                 220                 


Leu Leu Gly Asp Ile Leu Ser Asp Leu Ala Ala Gly Leu Val Gly Gly 
225                 230                 235                 240 


Leu Gly Leu Ala Pro Ser Gly Asn Ile Gly Asp Thr Thr Ala Val Phe 
                245                 250                 255     


Glu Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly Lys Gly Ile Ala 
            260                 265                 270         


Asn Pro Thr Ala Ala Ile Leu Ser Ala Ala Met Met Leu Asp Tyr Leu 
        275                 280                 285             


Gly Glu Lys Glu Ala Ala Lys Arg Val Glu Lys Ala Val Asp Leu Val 
    290                 295                 300                 


Leu Glu Arg Gly Pro Arg Thr Pro Asp Leu Gly Gly Asp Ala Thr Thr 
305                 310                 315                 320 


Glu Ala Phe Thr Glu Ala Val Val Glu Ala Leu Lys Ser Leu 
                325                 330                 


<210>  126
<211>  334
<212>  PRT
<213>  Thermus thermophilus

<400>  126

Met Ala Tyr Arg Ile Cys Leu Ile Glu Gly Asp Gly Ile Gly His Glu 
1               5                   10                  15      


Val Ile Pro Ala Ala Arg Arg Val Leu Glu Ala Thr Gly Leu Pro Leu 
            20                  25                  30          


Glu Phe Val Glu Ala Glu Ala Gly Trp Glu Thr Phe Glu Arg Arg Gly 
        35                  40                  45              


Thr Ser Val Pro Glu Glu Thr Val Glu Lys Ile Leu Ser Cys His Ala 
    50                  55                  60                  


Thr Leu Phe Gly Ala Ala Thr Ser Pro Thr Arg Lys Val Pro Gly Phe 
65                  70                  75                  80  


Phe Gly Ala Ile Arg Tyr Leu His Arg Arg Leu Asp Leu Tyr Ala Asn 
                85                  90                  95      


Val Arg Pro Ala Lys Ser Arg Pro Ile Pro Gly Ser Arg Pro Gly Val 
            100                 105                 110         


Asp Leu Ile Ile Val His Glu Asn Thr Glu Gly Leu Tyr Val Glu Gln 
        115                 120                 125             


Glu Arg Arg Tyr Leu Asp Val Ala Ile Ala Asp Ala Val Ile Ser Lys 
    130                 135                 140                 


Lys Ala Ser Glu Arg Ile Gly Arg Ala Ala Leu Arg Ile Ala Glu Gly 
145                 150                 155                 160 


Arg Pro Arg Lys Thr Leu His Ile Ala His Lys Ala Asn Val Leu Pro 
                165                 170                 175     


Leu Thr Gln Gly Leu Phe Leu Asp Thr Val Lys Glu Val Ala Lys Asp 
            180                 185                 190         


Phe Pro Leu Val Asn Val Gln Asp Ile Ile Val Asp Asn Cys Ala Met 
        195                 200                 205             


Gln Leu Val Met Arg Pro Glu Arg Phe Asp Val Ile Val Thr Thr Asn 
    210                 215                 220                 


Leu Leu Gly Asp Ile Leu Ser Asp Leu Ala Ala Gly Leu Val Gly Gly 
225                 230                 235                 240 


Leu Gly Leu Ala Pro Ser Gly Asn Ile Gly Asp Thr Thr Ala Val Phe 
                245                 250                 255     


Glu Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly Lys Gly Ile Ala 
            260                 265                 270         


Asn Pro Thr Ala Ala Ile Leu Ser Ala Ala Met Met Leu Asp Tyr Leu 
        275                 280                 285             


Gly Glu Lys Glu Ala Ala Lys Arg Val Glu Lys Ala Val Asp Leu Val 
    290                 295                 300                 


Leu Glu Arg Gly Pro Arg Thr Pro Asp Leu Gly Gly Asp Ala Thr Thr 
305                 310                 315                 320 


Glu Ala Phe Thr Lys Ala Val Val Glu Ala Leu Lys Ser Leu 
                325                 330                 


<210>  127
<211>  334
<212>  PRT
<213>  Thermus thermophilus

<400>  127

Met Ala Tyr Arg Ile Cys Leu Ile Glu Gly Asp Gly Ile Gly Tyr Glu 
1               5                   10                  15      


Val Ile Pro Ala Ala Arg Arg Val Leu Glu Ala Thr Gly Leu Pro Leu 
            20                  25                  30          


Glu Phe Val Glu Ala Glu Ala Gly Trp Glu Thr Phe Glu Arg Arg Gly 
        35                  40                  45              


Thr Ser Val Pro Glu Glu Thr Val Val Lys Ile Leu Ser Cys His Ala 
    50                  55                  60                  


Thr Leu Phe Gly Ala Ala Thr Ile Pro Thr Arg Lys Val Pro Gly Phe 
65                  70                  75                  80  


Phe Gly Ala Ile Met Ala Leu His Arg Arg Leu Asp Leu Tyr Ala Asn 
                85                  90                  95      


Val Arg Pro Ala Lys Ser Arg Pro Val Pro Gly Ser Arg Pro Gly Val 
            100                 105                 110         


Asp Leu Val Ile Val His Glu Asn Thr Glu Gly Leu Tyr Val Glu Gln 
        115                 120                 125             


Glu Arg Arg Tyr Leu Asp Val Ala Ile Ala Asp Ala Val Ile Ser Lys 
    130                 135                 140                 


Lys Ala Ser Glu Arg Ile Gly Arg Ala Ala Leu Arg Ile Ala Glu Gly 
145                 150                 155                 160 


Arg Pro Arg Lys Thr Leu His Ile Ala His Lys Ala Asn Val Leu Pro 
                165                 170                 175     


Leu Thr Gln Gly Leu Phe Leu Asp Thr Val Lys Glu Val Ala Lys Asp 
            180                 185                 190         


Phe Pro Leu Val Asn Val Gln Asp Ile Ile Val Asp Asn Cys Ala Thr 
        195                 200                 205             


Gln Leu Val Met Arg Pro Glu Arg Tyr Asp Val Ile Val Thr Thr Asn 
    210                 215                 220                 


Leu Leu Gly Asp Ile Leu Ser Asp Leu Ala Ala Gly Leu Met Gly Gly 
225                 230                 235                 240 


Leu Gly Leu Ala Pro Ser Gly Asn Ile Gly Asp Thr Thr Ala Val Phe 
                245                 250                 255     


Glu Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly Lys Gly Ile Ala 
            260                 265                 270         


Asn Pro Thr Ala Ala Ile Leu Ser Ala Ala Met Met Leu Asp Tyr Leu 
        275                 280                 285             


Gly Glu Lys Glu Ala Ala Lys Arg Val Glu Lys Ala Val Asp Leu Val 
    290                 295                 300                 


Leu Glu Arg Gly Pro Met Thr Pro Asp Leu Gly Gly Asp Ala Thr Thr 
305                 310                 315                 320 


Glu Ala Phe Thr Glu Ala Val Val Glu Ala Leu Lys Ser Leu 
                325                 330                 


<210>  128
<211>  334
<212>  PRT
<213>  Thermus thermophilus

<400>  128

Met Ala Tyr Arg Ile Cys Leu Ile Glu Gly Asp Gly Ile Gly Tyr Glu 
1               5                   10                  15      


Val Ile Pro Ala Ala Arg Arg Val Leu Glu Ala Thr Gly Leu Pro Leu 
            20                  25                  30          


Glu Phe Val Glu Ala Glu Ala Gly Trp Glu Thr Phe Glu Arg Arg Gly 
        35                  40                  45              


Thr Ser Val Pro Glu Glu Thr Val Val Lys Ile Leu Ser Cys His Ala 
    50                  55                  60                  


Thr Leu Phe Gly Ala Ala Thr Ile Pro Thr Arg Lys Val Pro Gly Phe 
65                  70                  75                  80  


Phe Gly Ala Ile Met Ala Leu His Arg Arg Leu Asp Leu Tyr Ala Asn 
                85                  90                  95      


Val Arg Pro Ala Lys Ser Arg Pro Val Pro Gly Ser Arg Pro Gly Val 
            100                 105                 110         


Asp Leu Val Ile Val His Glu Asn Thr Glu Gly Leu Tyr Val Glu Gln 
        115                 120                 125             


Glu Arg Arg Tyr Leu Asp Val Ala Ile Ala Asp Ala Val Ile Ser Lys 
    130                 135                 140                 


Lys Ala Ser Glu Arg Ile Gly Arg Ala Ala Leu Arg Ile Ala Glu Gly 
145                 150                 155                 160 


Arg Pro Arg Lys Thr Leu His Ile Ala His Lys Ala Asn Val Leu Pro 
                165                 170                 175     


Leu Thr Gln Gly Leu Phe Leu Asp Thr Val Lys Glu Val Ala Lys Asp 
            180                 185                 190         


Phe Pro Leu Val Asn Val Gln Asp Ile Ile Val Asp Asn Cys Ala Thr 
        195                 200                 205             


Gln Leu Val Met Arg Pro Glu Arg Tyr Asp Val Ile Val Thr Thr Asn 
    210                 215                 220                 


Leu Leu Gly Asp Ile Leu Ser Asp Leu Ala Ala Gly Leu Met Gly Gly 
225                 230                 235                 240 


Leu Gly Leu Ala Pro Ser Gly Asn Ile Gly Asp Thr Thr Ala Val Phe 
                245                 250                 255     


Glu Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly Lys Gly Ile Ala 
            260                 265                 270         


Asn Pro Thr Ala Ala Ile Leu Ser Ala Ala Met Met Leu Asp Tyr Leu 
        275                 280                 285             


Gly Glu Lys Glu Ala Ala Lys Arg Val Glu Lys Ala Val Asp Leu Val 
    290                 295                 300                 


Leu Glu Arg Gly Pro Met Thr Pro Asp Leu Gly Gly Asp Ala Thr Thr 
305                 310                 315                 320 


Glu Ala Phe Thr Glu Ala Val Val Glu Ala Leu Lys Ser Leu 
                325                 330                 


<210>  129
<211>  334
<212>  PRT
<213>  Thermus thermophilus

<400>  129

Met Ala Tyr Arg Ile Cys Leu Ile Glu Gly Asp Gly Ile Gly Tyr Glu 
1               5                   10                  15      


Val Ile Pro Ala Ala Arg Arg Val Leu Glu Ala Thr Gly Leu Pro Leu 
            20                  25                  30          


Glu Phe Val Glu Ala Glu Ala Gly Trp Glu Thr Phe Glu Arg Arg Gly 
        35                  40                  45              


Thr Ser Val Pro Glu Glu Thr Val Val Lys Ile Leu Ser Cys His Ala 
    50                  55                  60                  


Thr Leu Phe Gly Ala Ala Thr Ile Pro Thr Arg Lys Val Pro Gly Phe 
65                  70                  75                  80  


Phe Gly Ala Ile Met Ala Leu His Arg Arg Leu Asp Leu Tyr Ala Asn 
                85                  90                  95      


Val Arg Pro Ala Lys Ser Arg Pro Val Pro Gly Ser Arg Pro Gly Val 
            100                 105                 110         


Asp Leu Val Ile Val His Glu Asn Thr Glu Gly Leu Tyr Val Glu Gln 
        115                 120                 125             


Glu Arg Arg Tyr Leu Asp Val Ala Ile Ala Asp Ala Val Ile Ser Lys 
    130                 135                 140                 


Lys Ala Ser Glu Arg Ile Gly Arg Ala Ala Leu Arg Ile Ala Glu Gly 
145                 150                 155                 160 


Arg Pro Arg Lys Thr Leu His Ile Ala His Lys Ala Asn Val Leu Pro 
                165                 170                 175     


Leu Thr Gln Gly Leu Phe Leu Asp Thr Val Lys Glu Val Ala Lys Asp 
            180                 185                 190         


Phe Pro Leu Val Asn Val Gln Asp Ile Ile Val Asp Asn Cys Ala Thr 
        195                 200                 205             


Gln Leu Val Met Arg Pro Glu Arg Tyr Asp Val Ile Val Thr Thr Asn 
    210                 215                 220                 


Leu Leu Gly Asp Ile Leu Ser Asp Leu Ala Ala Gly Leu Met Gly Gly 
225                 230                 235                 240 


Leu Gly Leu Ala Pro Ser Gly Asn Ile Gly Asp Thr Thr Ala Val Phe 
                245                 250                 255     


Glu Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly Lys Gly Ile Ala 
            260                 265                 270         


Asn Pro Thr Ala Ala Ile Leu Ser Ala Ala Met Met Leu Asp Tyr Leu 
        275                 280                 285             


Gly Glu Lys Glu Ala Ala Lys Arg Val Glu Lys Ala Val Asp Leu Val 
    290                 295                 300                 


Leu Glu Arg Gly Pro Met Thr Pro Asp Leu Gly Gly Asp Ala Thr Thr 
305                 310                 315                 320 


Glu Ala Phe Thr Glu Ala Val Val Glu Ala Leu Lys Ser Leu 
                325                 330                 


<210>  130
<211>  334
<212>  PRT
<213>  Thermus thermophilus

<400>  130

Met Ala Tyr Arg Ile Cys Leu Ile Glu Gly Asp Gly Ile Gly Tyr Glu 
1               5                   10                  15      


Val Ile Pro Ala Ala Arg Arg Val Leu Glu Ala Thr Gly Leu Pro Leu 
            20                  25                  30          


Glu Phe Val Glu Ala Glu Ala Gly Trp Glu Thr Phe Glu Arg Arg Gly 
        35                  40                  45              


Thr Ser Val Pro Glu Glu Thr Val Val Lys Ile Leu Ser Cys His Ala 
    50                  55                  60                  


Thr Leu Phe Gly Ala Ala Thr Ile Pro Thr Arg Lys Val Pro Gly Phe 
65                  70                  75                  80  


Phe Gly Ala Ile Met Ala Leu His Arg Arg Leu Asp Leu Tyr Ala Asn 
                85                  90                  95      


Val Arg Pro Ala Lys Ser Arg Pro Val Pro Gly Ser Arg Pro Gly Val 
            100                 105                 110         


Asp Leu Val Ile Val His Glu Asn Thr Glu Gly Leu Tyr Val Glu Gln 
        115                 120                 125             


Glu Arg Arg Tyr Leu Asp Val Ala Ile Ala Asp Ala Val Ile Ser Lys 
    130                 135                 140                 


Lys Ala Ser Glu Arg Ile Gly Arg Ala Ala Leu Arg Ile Ala Glu Gly 
145                 150                 155                 160 


Arg Pro Arg Lys Thr Leu His Ile Ala His Lys Ala Asn Val Leu Pro 
                165                 170                 175     


Leu Thr Gln Gly Leu Phe Leu Asp Thr Val Lys Glu Val Ala Lys Asp 
            180                 185                 190         


Phe Pro Leu Val Asn Val Gln Asp Ile Ile Val Asp Asn Cys Ala Thr 
        195                 200                 205             


Gln Leu Val Met Arg Pro Glu Arg Tyr Asp Val Ile Val Thr Thr Asn 
    210                 215                 220                 


Leu Leu Gly Asp Ile Leu Ser Asp Leu Ala Ala Gly Leu Met Gly Gly 
225                 230                 235                 240 


Leu Gly Leu Ala Pro Ser Gly Asn Ile Gly Asp Thr Thr Ala Val Phe 
                245                 250                 255     


Glu Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly Lys Gly Ile Ala 
            260                 265                 270         


Asn Pro Thr Ala Ala Ile Leu Ser Ala Ala Met Met Leu Asp Tyr Leu 
        275                 280                 285             


Gly Glu Lys Glu Ala Ala Lys Arg Val Glu Lys Ala Val Asp Leu Val 
    290                 295                 300                 


Leu Glu Arg Gly Pro Met Thr Pro Asp Leu Gly Gly Asp Ala Thr Thr 
305                 310                 315                 320 


Glu Ala Phe Thr Glu Ala Val Val Glu Ala Leu Lys Ser Leu 
                325                 330                 


<210>  131
<211>  360
<212>  PRT
<213>  Trichophyton equinum

<400>  131

Met Ala Ala Arg Thr Leu Arg Ile Gly Leu Ile Pro Gly Asp Gly Ile 
1               5                   10                  15      


Gly Arg Glu Val Ile Pro Ala Gly Arg Arg Ile Leu Glu Ala Leu Pro 
            20                  25                  30          


Ala Ser Leu Gly Leu Lys Phe Ser Phe Val Asp Leu Asp Ala Gly Tyr 
        35                  40                  45              


Asp Thr Phe Leu Arg Thr Lys Thr Ala Leu Pro Asp Lys Thr Val Glu 
    50                  55                  60                  


Thr Leu Lys Lys Glu Cys Asp Gly Ala Leu Phe Gly Ala Val Ser Ser 
65                  70                  75                  80  


Pro Ser Thr Lys Val Ala Gly Tyr Ser Ser Pro Ile Val Ala Leu His 
                85                  90                  95      


Lys Lys Leu Asp Leu Tyr Ala Asn Val Arg Pro Val Lys Thr Thr Ala 
            100                 105                 110         


Gly Ala Asn Thr Ser Ala Arg Pro Ile Asp Leu Val Ile Val His Glu 
        115                 120                 125             


Asn Thr Glu Asp Leu Tyr Val Lys Glu Glu Lys Thr Tyr Asp Thr Pro 
    130                 135                 140                 


Asn Gly Lys Val Ala Glu Ala Ile Lys Arg Ile Ser Glu Asn Ala Ser 
145                 150                 155                 160 


Phe Arg Ile Gly Thr Met Ala Gly Glu Ile Ala Leu Arg Arg Gln Lys 
                165                 170                 175     


Ile Arg Gln Ala Gln Ser Ala Asn Thr Thr Thr Thr Ser Pro Met Val 
            180                 185                 190         


Thr Ile Thr His Lys Ser Asn Val Leu Ser Gln Ser Asp Gly Leu Phe 
        195                 200                 205             


Arg Glu Thr Cys Arg Lys Ala Leu Ala Asn Glu Lys Phe Ser Gly Val 
    210                 215                 220                 


Asn Val Glu Glu Gln Ile Val Asp Ser Met Val Tyr Lys Leu Phe Arg 
225                 230                 235                 240 


Gln Pro Ser Tyr Tyr Asp Val Ile Val Ala Pro Asn Leu Tyr Gly Asp 
                245                 250                 255     


Ile Leu Ser Asp Gly Ala Ala Ala Leu Val Gly Ser Leu Gly Leu Val 
            260                 265                 270         


Pro Ser Ala Asn Val Gly Asp Gly Phe Ala Ile Gly Glu Pro Cys His 
        275                 280                 285             


Gly Ser Ala Pro Asp Ile Glu Gly Lys Gly Ile Ala Asn Pro Ile Ala 
    290                 295                 300                 


Thr Ile Arg Ser Thr Ala Leu Met Leu Glu Phe Leu Gly Glu Gly Ala 
305                 310                 315                 320 


Ala Ala Ala Lys Ile Tyr Ala Ala Val Asp Ala Asn Leu Asp Glu Gly 
                325                 330                 335     


Lys Leu Leu Ser Pro Asp Leu Gly Gly Lys Ala Thr Thr Ala Glu Val 
            340                 345                 350         


Leu Glu Asp Val Leu Lys Lys Leu 
        355                 360 


<210>  132
<211>  344
<212>  PRT
<213>  Truepera radiovictrix

<400>  132

Met Thr Arg Arg Ala Tyr Thr Ile Thr Leu Ile Pro Gly Asp Gly Ile 
1               5                   10                  15      


Gly Gln Glu Val Val Pro Ala Ala Glu Arg Leu Leu Arg Glu Thr Gly 
            20                  25                  30          


Leu Pro Leu Glu Met His Tyr Ala Glu Ala Gly Trp Asp Thr Phe Gln 
        35                  40                  45              


Lys Val Gly Lys Ser Val Pro Asp Glu Thr Leu Glu Arg Val Lys Ala 
    50                  55                  60                  


Ser Asp Ala Thr Leu Ala Gly Ala Phe Thr Ser Pro Ser Gly Ser Gln 
65                  70                  75                  80  


Lys Val Pro Gly Phe Gln Gly Ala Ile Arg Tyr Leu His Arg Thr Leu 
                85                  90                  95      


Asp Leu Phe Ala Asn Leu Arg Pro Thr Lys Ser Arg Pro Ile Pro Gly 
            100                 105                 110         


Ser Met Lys Asn Val Asp Met Leu Met Val His Glu Asn Thr Gln Gly 
        115                 120                 125             


Leu Tyr Val Glu Gln Glu Arg Arg Tyr Gly Asp Val Ala Ile Ala Asp 
    130                 135                 140                 


Cys Val Ile Thr Lys Gly Ala Ser Glu Arg Ile Ala Lys Val Ala Leu 
145                 150                 155                 160 


Lys Glu Ala Gln Arg Arg Arg Arg Lys Leu Ala Val Ile His Lys Ala 
                165                 170                 175     


Asn Val Leu Pro Leu Thr Thr Gly Leu Phe Leu Glu Thr Ala Leu Glu 
            180                 185                 190         


Ala Ala Lys Ala Phe Pro Glu Val Glu Thr Tyr Asp Ile Ile Val Asp 
        195                 200                 205             


Ala Ala Ala Met Lys Leu Val Arg Asp Pro Gln Ser Phe Asp Val Leu 
    210                 215                 220                 


Val Thr Thr Asn Leu Phe Gly Asp Ile Leu Ser Asp Leu Met Ala Gly 
225                 230                 235                 240 


Leu Val Gly Gly Leu Gly Leu Ala Pro Ser Ala Asn Ile Gly Glu Arg 
                245                 250                 255     


Thr Ala Ile Phe Glu Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly 
            260                 265                 270         


Lys Gly Val Ala Asn Pro Ala Ala Thr Phe Leu Thr Ala Ala Met Met 
        275                 280                 285             


Leu Asp Tyr Leu Gly Glu Ala Ala Thr Ala Lys Arg Ile Asp Arg Ala 
    290                 295                 300                 


Val Asp Thr Val Leu Glu Glu Gly Pro Arg Thr Ala Asp Leu Gly Gly 
305                 310                 315                 320 


Lys Ala Asp Thr Glu Glu Phe Thr Asp Ala Val Ile Glu Ala Phe Arg 
                325                 330                 335     


Ser Leu Ala Pro His Glu Ala Ala 
            340                 


<210>  133
<211>  344
<212>  PRT
<213>  Truepera radiovictrix

<400>  133

Met Thr Arg Arg Ala Tyr Thr Ile Thr Leu Ile Pro Gly Asp Gly Ile 
1               5                   10                  15      


Gly Gln Glu Val Val Pro Ala Ala Glu Arg Leu Leu Arg Glu Thr Gly 
            20                  25                  30          


Leu Pro Leu Glu Met His Tyr Ala Glu Ala Gly Trp Asp Thr Phe Gln 
        35                  40                  45              


Lys Val Gly Lys Ser Val Pro Asp Glu Thr Leu Glu Arg Val Lys Ala 
    50                  55                  60                  


Ser Asp Ala Thr Leu Ala Gly Ala Phe Thr Ser Pro Ser Gly Ser Gln 
65                  70                  75                  80  


Lys Val Pro Gly Phe Gln Gly Ala Ile Arg Tyr Leu His Arg Thr Leu 
                85                  90                  95      


Asp Leu Phe Ala Asn Leu Arg Pro Thr Lys Ser Arg Pro Ile Pro Gly 
            100                 105                 110         


Ser Met Lys Asn Val Asp Met Leu Met Val His Glu Asn Thr Gln Gly 
        115                 120                 125             


Leu Tyr Val Glu Gln Glu Arg Arg Tyr Gly Asp Val Ala Ile Ala Asp 
    130                 135                 140                 


Cys Val Ile Thr Lys Gly Ala Ser Glu Arg Ile Ala Lys Val Ala Leu 
145                 150                 155                 160 


Lys Glu Ala Gln Arg Arg Arg Arg Lys Leu Ala Val Ile His Lys Ala 
                165                 170                 175     


Asn Val Leu Pro Leu Thr Thr Gly Leu Phe Leu Glu Thr Ala Leu Glu 
            180                 185                 190         


Ala Ala Lys Ala Phe Pro Glu Val Glu Thr Tyr Asp Ile Ile Val Asp 
        195                 200                 205             


Ala Ala Ala Met Lys Leu Val Arg Asp Pro Gln Ser Phe Asp Val Leu 
    210                 215                 220                 


Val Thr Thr Asn Leu Phe Gly Asp Ile Leu Ser Asp Leu Met Ala Gly 
225                 230                 235                 240 


Leu Val Gly Gly Leu Gly Leu Ala Pro Ser Ala Asn Ile Gly Glu Arg 
                245                 250                 255     


Thr Ala Ile Phe Glu Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly 
            260                 265                 270         


Lys Gly Val Ala Asn Pro Ala Ala Thr Phe Leu Thr Ala Ala Met Met 
        275                 280                 285             


Leu Asp Tyr Leu Gly Glu Ala Ala Thr Ala Lys Arg Ile Asp Arg Ala 
    290                 295                 300                 


Val Asp Thr Val Leu Glu Glu Gly Pro Arg Thr Ala Asp Leu Gly Gly 
305                 310                 315                 320 


Lys Ala Asp Thr Glu Glu Phe Thr Asp Ala Val Ile Glu Ala Phe Arg 
                325                 330                 335     


Ser Leu Ala Pro His Glu Ala Ala 
            340                 


<210>  134
<211>  359
<212>  PRT
<213>  Uncinocarpus reesii

<400>  134

Met Ala Ala Ser Arg Thr Leu Arg Ile Gly Leu Ile Pro Gly Asp Gly 
1               5                   10                  15      


Ile Gly Arg Glu Val Ile Pro Ala Gly Arg Arg Ile Leu Glu Ala Leu 
            20                  25                  30          


Pro Ala Ser Leu Gly Leu Lys Phe Ser Phe Val Asp Leu Glu Ala Gly 
        35                  40                  45              


Phe Asp Thr Phe Lys Gln Thr Lys Thr Ala Leu Pro Asp Lys Thr Val 
    50                  55                  60                  


Glu Thr Leu Lys Lys Glu Cys Asp Gly Ala Leu Phe Gly Ala Val Ser 
65                  70                  75                  80  


Ser Pro Thr Thr Lys Val Ala Gly Tyr Ser Ser Pro Ile Val Ala Leu 
                85                  90                  95      


His Lys Arg Leu Asp Leu Tyr Ala Asn Val Arg Pro Val Lys Thr Thr 
            100                 105                 110         


Ala Gly Ala Lys Leu Ala Ala Pro Ile Asp Leu Val Ile Val His Glu 
        115                 120                 125             


Asn Thr Glu Asp Leu Tyr Val Lys Asp Glu Lys Thr Tyr Asp Thr Pro 
    130                 135                 140                 


Glu Gly Lys Val Ala Glu Ala Ile Lys Arg Ile Ser Glu Arg Ala Ser 
145                 150                 155                 160 


Ser Arg Ile Ala Thr Ile Ala Gly Asp Ile Ala Leu Arg Arg Gln Lys 
                165                 170                 175     


Ile Arg Asp Ala Gly His Pro Ala Ala Arg Ser Ser Pro Met Val Thr 
            180                 185                 190         


Ile Thr His Lys Ser Asn Val Leu Ser Gln Thr Asp Gly Leu Phe Arg 
        195                 200                 205             


Glu Ala Ala Arg Lys Ala Leu Ser Gln Gln Lys Phe Ser Ala Val Glu 
    210                 215                 220                 


Val Glu Glu Gln Ile Val Asp Ser Met Val Tyr Lys Leu Phe Arg Gln 
225                 230                 235                 240 


Pro Ser Tyr Tyr Asp Val Ile Val Ala Pro Asn Leu Tyr Gly Asp Ile 
                245                 250                 255     


Leu Ser Asp Gly Ala Ala Ala Leu Val Gly Ser Leu Gly Leu Val Pro 
            260                 265                 270         


Ser Ala Asn Val Gly Asp Gly Phe Ala Ile Gly Glu Pro Cys His Gly 
        275                 280                 285             


Ser Ala Pro Asp Ile Glu Gly Lys Gly Ile Ala Asn Pro Ile Ala Thr 
    290                 295                 300                 


Leu Arg Ser Ala Gly Leu Met Leu Glu Phe Leu Gly Glu Glu Lys Ala 
305                 310                 315                 320 


Ala Ala Lys Ile Tyr Ala Ala Val Asp Ala Asn Leu Asp Glu Gly Lys 
                325                 330                 335     


Tyr Leu Ser Pro Asp Leu Gly Gly Lys Ala Thr Thr Gln Glu Val Leu 
            340                 345                 350         


Asp Asp Val Leu Arg Arg Leu 
        355                 


<210>  135
<211>  359
<212>  PRT
<213>  Uncinocarpus reesii

<400>  135

Met Ala Ala Ser Arg Thr Leu Arg Ile Gly Leu Ile Pro Gly Asp Gly 
1               5                   10                  15      


Ile Gly Arg Glu Val Ile Pro Ala Gly Arg Arg Ile Leu Glu Ala Leu 
            20                  25                  30          


Pro Ala Ser Leu Gly Leu Lys Phe Ser Phe Val Asp Leu Glu Ala Gly 
        35                  40                  45              


Phe Asp Thr Phe Lys Gln Thr Lys Thr Ala Leu Pro Asp Lys Thr Val 
    50                  55                  60                  


Glu Thr Leu Lys Lys Glu Cys Asp Gly Ala Leu Phe Gly Ala Val Ser 
65                  70                  75                  80  


Ser Pro Thr Thr Lys Val Ala Gly Tyr Ser Ser Pro Ile Val Ala Leu 
                85                  90                  95      


His Lys Arg Leu Asp Leu Tyr Ala Asn Val Arg Pro Val Lys Thr Thr 
            100                 105                 110         


Ala Gly Ala Lys Leu Ala Ala Pro Ile Asp Leu Val Ile Val His Glu 
        115                 120                 125             


Asn Thr Glu Asp Leu Tyr Val Lys Asp Glu Lys Thr Tyr Asp Thr Pro 
    130                 135                 140                 


Glu Gly Lys Val Ala Glu Ala Ile Lys Arg Ile Ser Glu Arg Ala Ser 
145                 150                 155                 160 


Ser Arg Ile Ala Thr Ile Ala Gly Asp Ile Ala Leu Arg Arg Gln Lys 
                165                 170                 175     


Ile Arg Asp Ala Gly His Pro Ala Ala Arg Ser Ser Pro Met Val Thr 
            180                 185                 190         


Ile Thr His Lys Ser Asn Val Leu Ser Gln Thr Asp Gly Leu Phe Arg 
        195                 200                 205             


Glu Ala Ala Arg Lys Ala Leu Ser Gln Gln Lys Phe Ser Ala Val Glu 
    210                 215                 220                 


Val Glu Glu Gln Ile Val Asp Ser Met Val Tyr Lys Leu Phe Arg Gln 
225                 230                 235                 240 


Pro Ser Tyr Tyr Asp Val Ile Val Ala Pro Asn Leu Tyr Gly Asp Ile 
                245                 250                 255     


Leu Ser Asp Gly Ala Ala Ala Leu Val Gly Ser Leu Gly Leu Val Pro 
            260                 265                 270         


Ser Ala Asn Val Gly Asp Gly Phe Ala Ile Gly Glu Pro Cys His Gly 
        275                 280                 285             


Ser Ala Pro Asp Ile Glu Gly Lys Gly Ile Ala Asn Pro Ile Ala Thr 
    290                 295                 300                 


Leu Arg Ser Ala Gly Leu Met Leu Glu Phe Leu Gly Glu Glu Lys Ala 
305                 310                 315                 320 


Ala Ala Lys Ile Tyr Ala Ala Val Asp Ala Asn Leu Asp Glu Gly Lys 
                325                 330                 335     


Tyr Leu Ser Pro Asp Leu Gly Gly Lys Ala Thr Thr Gln Glu Val Leu 
            340                 345                 350         


Asp Asp Val Leu Arg Arg Leu 
        355                 


<210>  136
<211>  316
<212>  PRT
<213>  Verticillium albo-atrum

<400>  136

Met Ser Ile Arg Thr Leu Arg Ile Gly Leu Ile Pro Gly Asp Gly Ile 
1               5                   10                  15      


Gly Lys Glu Val Ile Pro Ala Gly Arg Arg Ile Leu Glu Ala Leu Pro 
            20                  25                  30          


Ser Tyr Leu Gly Leu Lys Phe Glu Phe Thr Asp Leu His Ala Gly Phe 
        35                  40                  45              


Glu Thr Phe Glu Arg Thr Gly Ala Ala Leu Pro Asp Lys Thr Val Glu 
    50                  55                  60                  


Ile Leu Arg Asn Glu Cys Asp Gly Ala Leu Phe Gly Ala Val Ser Ser 
65                  70                  75                  80  


Pro Ser Ser Pro Val Lys Gly Tyr Ser Ser Pro Ile Val Ala Leu His 
                85                  90                  95      


Lys Lys Leu Asp Leu Tyr Ala Asn Val Arg Pro Val Lys Thr Val Leu 
            100                 105                 110         


Ser Ala Ala Lys Pro Ile Asp Met Val Ile Val His Glu Asn Thr Glu 
        115                 120                 125             


Asp Leu Tyr Val Lys Glu Glu Thr Thr Arg Asp Thr Pro Asp Gly Lys 
    130                 135                 140                 


Val Ala Glu Ala Ile Lys Arg Ile Ser Glu Arg Ala Ser His Arg Ile 
145                 150                 155                 160 


Ala Thr Met Ala Gly Asp Ile Ala Leu Arg Arg Gln Lys Ile Arg Ala 
                165                 170                 175     


Ala Gly Ala Pro Ser Ile His Gln Ser Pro Leu Val Thr Ile Thr His 
            180                 185                 190         


Lys Ser Asn Val Leu Leu Arg Leu Lys Asn Val Ile Val Asp Pro Asn 
        195                 200                 205             


Leu Tyr Gly Asp Ile Leu Ser Asp Asp Ala Ala Ala Leu Val Gly Ser 
    210                 215                 220                 


Leu Gly Leu Val Pro Ser Ala Asn Val Gly Glu Gly Phe Ala Ile Gly 
225                 230                 235                 240 


Glu Pro Cys His Gly Ser Ala Pro Asp Ile Met Gly Gln Asn Ile Ala 
                245                 250                 255     


Asn Pro Ile Ala Thr Leu Arg Ser Ala Ala Leu Met Leu Glu Phe Leu 
            260                 265                 270         


Asp Glu Glu Ala Ala Ala Ala Lys Ile Tyr Ala Ala Val Asp Ala Asn 
        275                 280                 285             


Leu Thr Glu Gly Lys Leu Leu Ser Pro Asp Leu Gly Gly Thr Ala Lys 
    290                 295                 300                 


Thr Thr Glu Val Ile Glu Asp Ile Leu Arg Arg Leu 
305                 310                 315     


<210>  137
<211>  316
<212>  PRT
<213>  Verticillium albo-atrum

<400>  137

Met Ser Ile Arg Thr Leu Arg Ile Gly Leu Ile Pro Gly Asp Gly Ile 
1               5                   10                  15      


Gly Lys Glu Val Ile Pro Ala Gly Arg Arg Ile Leu Glu Ala Leu Pro 
            20                  25                  30          


Ser Tyr Leu Gly Leu Lys Phe Glu Phe Thr Asp Leu His Ala Gly Phe 
        35                  40                  45              


Glu Thr Phe Glu Arg Thr Gly Ala Ala Leu Pro Asp Lys Thr Val Glu 
    50                  55                  60                  


Ile Leu Arg Asn Glu Cys Asp Gly Ala Leu Phe Gly Ala Val Ser Ser 
65                  70                  75                  80  


Pro Ser Ser Pro Val Lys Gly Tyr Ser Ser Pro Ile Val Ala Leu His 
                85                  90                  95      


Lys Lys Leu Asp Leu Tyr Ala Asn Val Arg Pro Val Lys Thr Val Leu 
            100                 105                 110         


Ser Ala Ala Lys Pro Ile Asp Met Val Ile Val His Glu Asn Thr Glu 
        115                 120                 125             


Asp Leu Tyr Val Lys Glu Glu Thr Thr Arg Asp Thr Pro Asp Gly Lys 
    130                 135                 140                 


Val Ala Glu Ala Ile Lys Arg Ile Ser Glu Arg Ala Ser His Arg Ile 
145                 150                 155                 160 


Ala Thr Met Ala Gly Asp Ile Ala Leu Arg Arg Gln Lys Ile Arg Ala 
                165                 170                 175     


Ala Gly Ala Pro Ser Ile His Gln Ser Pro Leu Val Thr Ile Thr His 
            180                 185                 190         


Lys Ser Asn Val Leu Leu Arg Leu Lys Asn Val Ile Val Asp Pro Asn 
        195                 200                 205             


Leu Tyr Gly Asp Ile Leu Ser Asp Asp Ala Ala Ala Leu Val Gly Ser 
    210                 215                 220                 


Leu Gly Leu Val Pro Ser Ala Asn Val Gly Glu Gly Phe Ala Ile Gly 
225                 230                 235                 240 


Glu Pro Cys His Gly Ser Ala Pro Asp Ile Met Gly Gln Asn Ile Ala 
                245                 250                 255     


Asn Pro Ile Ala Thr Leu Arg Ser Ala Ala Leu Met Leu Glu Phe Leu 
            260                 265                 270         


Asp Glu Glu Ala Ala Ala Ala Lys Ile Tyr Ala Ala Val Asp Ala Asn 
        275                 280                 285             


Leu Thr Glu Gly Lys Leu Leu Ser Pro Asp Leu Gly Gly Thr Ala Lys 
    290                 295                 300                 


Thr Thr Glu Val Ile Glu Asp Ile Leu Arg Arg Leu 
305                 310                 315     


<210>  138
<211>  357
<212>  PRT
<213>  Verticillium dahliae

<400>  138

Met Ser Ile Arg Thr Leu Arg Ile Gly Leu Ile Pro Gly Asp Gly Ile 
1               5                   10                  15      


Gly Lys Glu Val Ile Pro Ala Gly Arg Arg Ile Leu Glu Ala Leu Pro 
            20                  25                  30          


Ser Tyr Leu Gly Leu Lys Phe Glu Phe Thr Asp Leu His Ala Gly Phe 
        35                  40                  45              


Glu Thr Phe Glu Arg Thr Gly Ala Ala Leu Pro Asp Lys Thr Val Glu 
    50                  55                  60                  


Ile Leu Arg Asn Glu Cys Asp Gly Ala Leu Phe Gly Ala Val Ser Ser 
65                  70                  75                  80  


Pro Ser Ser Pro Val Lys Gly Tyr Ser Ser Pro Ile Val Ala Leu His 
                85                  90                  95      


Lys Lys Leu Asp Leu Tyr Ala Asn Val Arg Pro Val Lys Thr Val Leu 
            100                 105                 110         


Ser Ala Ala Lys Pro Ile Asp Met Val Ile Val His Glu Asn Thr Glu 
        115                 120                 125             


Asp Leu Tyr Val Lys Glu Glu Thr Thr Arg Asp Thr Pro Asp Gly Lys 
    130                 135                 140                 


Val Ala Glu Ala Ile Lys Arg Ile Ser Glu Arg Ala Ser His Arg Ile 
145                 150                 155                 160 


Ala Thr Met Ala Gly Asp Ile Ala Leu Arg Arg Gln Lys Ile Arg Ala 
                165                 170                 175     


Ala Gly Ala Pro Ser Ile His Gln Ser Pro Leu Val Thr Ile Thr His 
            180                 185                 190         


Lys Ser Asn Val Leu Ser Gln Thr Asp Gly Leu Phe Arg Ala Thr Ser 
        195                 200                 205             


Arg Ala Ala Leu Ala Ala Pro Arg Phe Ala Asp Ala Val Ala Val Glu 
    210                 215                 220                 


Glu Gln Ile Val Asp Ser Met Val Tyr Lys Leu Phe Arg Gln Pro Glu 
225                 230                 235                 240 


Ala Tyr Asp Val Ile Val Ala Pro Asn Leu Tyr Gly Asp Ile Leu Ser 
                245                 250                 255     


Asp Gly Ala Ala Ala Leu Val Gly Ser Leu Gly Leu Val Pro Ser Ala 
            260                 265                 270         


Asn Val Gly Glu Gly Phe Ala Ile Gly Glu Pro Cys His Gly Ser Ala 
        275                 280                 285             


Pro Asp Ile Met Gly Gln Asn Ile Ala Asn Pro Ile Ala Thr Leu Arg 
    290                 295                 300                 


Ser Ala Ala Leu Met Leu Glu Phe Leu Asp Glu Glu Ala Ala Ala Ala 
305                 310                 315                 320 


Lys Ile Tyr Ala Ala Val Asp Ala Asn Leu Thr Glu Gly Lys Leu Leu 
                325                 330                 335     


Ser Pro Asp Leu Gly Gly Thr Ala Lys Thr Thr Glu Val Ile Glu Asp 
            340                 345                 350         


Ile Leu Arg Arg Leu 
        355         


<210>  139
<211>  406
<212>  PRT
<213>  Sphingobium yanoikuyae

<400>  139

Met Ala Lys Ile Lys Val Lys Asn Pro Val Val Glu Ile Asp Gly Asp 
1               5                   10                  15      


Glu Met Thr Arg Ile Ile Trp Glu Trp Ile Arg Glu Arg Leu Ile Leu 
            20                  25                  30          


Pro Tyr Leu Asp Val Asp Leu Lys Tyr Tyr Asp Leu Ser Val Glu Lys 
        35                  40                  45              


Arg Asp Glu Thr Ser Asp Gln Ile Thr Ile Asp Ala Ala Asn Ala Ile 
    50                  55                  60                  


Lys Glu Tyr Gly Val Gly Val Lys Cys Ala Thr Ile Thr Pro Asp Glu 
65                  70                  75                  80  


Ala Arg Val Glu Glu Phe Gly Leu Lys Lys Met Trp Lys Ser Pro Asn 
                85                  90                  95      


Gly Thr Ile Arg Asn Ile Leu Gly Gly Val Val Phe Arg Glu Pro Ile 
            100                 105                 110         


Val Ile Lys Asn Val Pro Arg Leu Val Pro Gly Trp Thr Asp Pro Ile 
        115                 120                 125             


Val Val Gly Arg His Ala Phe Gly Asp Gln Tyr Lys Ala Thr Asp Phe 
    130                 135                 140                 


Lys Val Pro Gly Ala Gly Thr Leu Thr Met Lys Trp Val Gly Thr Asn 
145                 150                 155                 160 


Gly Glu Glu Leu Glu Tyr Glu Val Phe Glu Phe Pro Ser Ala Gly Val 
                165                 170                 175     


Ala Met Gly Met Tyr Asn Leu Asp Glu Ser Ile Arg Asp Phe Ala Lys 
            180                 185                 190         


Ala Ser Phe Asn Tyr Gly Leu Asn Arg Gly Trp Pro Val Tyr Leu Ser 
        195                 200                 205             


Thr Lys Asn Thr Ile Leu Lys Ala Tyr Asp Gly Arg Phe Lys Asp Leu 
    210                 215                 220                 


Phe Gln Glu Val Phe Asp Ala Glu Phe Ala Asp Lys Phe Lys Ala Ala 
225                 230                 235                 240 


Gly Ile Val Tyr Glu His Arg Leu Ile Asp Asp Met Val Ala Ser Ala 
                245                 250                 255     


Leu Lys Trp Ser Gly Lys Phe Val Trp Ala Cys Lys Asn Tyr Asp Gly 
            260                 265                 270         


Asp Val Gln Ser Asp Thr Val Ala Gln Gly Phe Gly Ser Leu Gly Leu 
        275                 280                 285             


Met Thr Ser Val Leu Leu Ser Pro Asp Gly Lys Thr Val Glu Ala Glu 
    290                 295                 300                 


Ala Ala His Gly Thr Val Thr Arg His Tyr Arg Gln His Gln Gln Gly 
305                 310                 315                 320 


Lys Ala Thr Ser Thr Asn Pro Ile Ala Ser Ile Phe Ala Trp Thr Gln 
                325                 330                 335     


Gly Leu Ser Phe Arg Gly Lys Phe Asp Asp Thr Pro Asp Val Val Lys 
            340                 345                 350         


Phe Ala Glu Thr Leu Glu Gln Val Cys Ile Lys Thr Val Glu Gly Gly 
        355                 360                 365             


Ala Met Thr Lys Asp Leu Ala Leu Leu Ile Gly Pro Asp Gln Ala Trp 
    370                 375                 380                 


Met Thr Thr Glu Gln Phe Phe Glu Ala Ile Arg Val Asn Leu Glu Ala 
385                 390                 395                 400 


Glu Met Ala Lys Trp Ala 
                405     


<210>  140
<211>  414
<212>  PRT
<213>  Homo sapiens

<400>  140

Met Ser Lys Lys Ile Ser Gly Gly Ser Val Val Glu Met Gln Gly Asp 
1               5                   10                  15      


Glu Met Thr Arg Ile Ile Trp Glu Leu Ile Lys Glu Lys Leu Ile Phe 
            20                  25                  30          


Pro Tyr Val Glu Leu Asp Leu His Ser Tyr Asp Leu Gly Ile Glu Asn 
        35                  40                  45              


Arg Asp Ala Thr Asn Asp Gln Val Thr Lys Asp Ala Ala Glu Ala Ile 
    50                  55                  60                  


Lys Lys His Asn Val Gly Val Lys Cys Ala Thr Ile Thr Pro Asp Glu 
65                  70                  75                  80  


Lys Arg Val Glu Glu Phe Lys Leu Lys Gln Met Trp Lys Ser Pro Asn 
                85                  90                  95      


Gly Thr Ile Arg Asn Ile Leu Gly Gly Thr Val Phe Arg Glu Ala Ile 
            100                 105                 110         


Ile Cys Lys Asn Ile Pro Arg Leu Val Ser Gly Trp Val Lys Pro Ile 
        115                 120                 125             


Ile Ile Gly Arg His Ala Tyr Gly Asp Gln Tyr Arg Ala Thr Asp Phe 
    130                 135                 140                 


Val Val Pro Gly Pro Gly Lys Val Glu Met Thr Tyr Thr Pro Ser Asp 
145                 150                 155                 160 


Gly Thr Gln Lys Val Thr Tyr Leu Val His Asn Phe Glu Glu Gly Gly 
                165                 170                 175     


Gly Val Ala Met Gly Met Tyr Asn Gln Asp Lys Ser Ile Glu Asp Phe 
            180                 185                 190         


Ala His Ser Ser Phe Gln Met Ala Leu Ser Lys Gly Trp Pro Leu Tyr 
        195                 200                 205             


Leu Ser Thr Lys Asn Thr Ile Leu Lys Lys Tyr Asp Gly Arg Phe Lys 
    210                 215                 220                 


Asp Ile Phe Gln Glu Ile Tyr Asp Lys Gln Tyr Lys Ser Gln Phe Glu 
225                 230                 235                 240 


Ala Gln Lys Ile Trp Tyr Glu His Arg Leu Ile Asp Asp Met Val Ala 
                245                 250                 255     


Gln Ala Met Lys Ser Glu Gly Gly Phe Ile Trp Ala Cys Lys Asn Tyr 
            260                 265                 270         


Asp Gly Asp Val Gln Ser Asp Ser Val Ala Gln Gly Tyr Gly Ser Leu 
        275                 280                 285             


Gly Met Met Thr Ser Val Leu Val Cys Pro Asp Gly Lys Thr Val Glu 
    290                 295                 300                 


Ala Glu Ala Ala His Gly Thr Val Thr Arg His Tyr Arg Met Tyr Gln 
305                 310                 315                 320 


Lys Gly Gln Glu Thr Ser Thr Asn Pro Ile Ala Ser Ile Phe Ala Trp 
                325                 330                 335     


Thr Arg Gly Leu Ala His Arg Ala Lys Leu Asp Asn Asn Lys Glu Leu 
            340                 345                 350         


Ala Phe Phe Ala Asn Ala Leu Glu Glu Val Ser Ile Glu Thr Ile Glu 
        355                 360                 365             


Ala Gly Phe Met Thr Lys Asp Leu Ala Ala Cys Ile Lys Gly Leu Pro 
    370                 375                 380                 


Asn Val Gln Arg Ser Asp Tyr Leu Asn Thr Phe Glu Phe Met Asp Lys 
385                 390                 395                 400 


Leu Gly Glu Asn Leu Lys Ile Lys Leu Ala Gln Ala Lys Leu 
                405                 410                 


<210>  141
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  141

Met Ala Gly Tyr Leu Arg Val Val Arg Ser Leu Cys Arg Ala Ser Gly 
1               5                   10                  15      


Ser Arg Pro Ala Trp Ala Pro Ala Ala Leu Thr Ala Pro Thr Ser Gln 
            20                  25                  30          


Glu Gln Pro Arg Arg His Tyr Ala Asp Lys Arg Ile Lys Val Ala Lys 
        35                  40                  45              


Pro Val Val Glu Met Asp Gly Asp Glu Met Thr Arg Ile Ile Trp Gln 
    50                  55                  60                  


Phe Ile Lys Glu Lys Leu Ile Leu Pro His Val Asp Ile Gln Leu Lys 
65                  70                  75                  80  


Tyr Phe Asp Leu Gly Leu Pro Asn Arg Asp Gln Thr Asp Asp Gln Val 
                85                  90                  95      


Thr Ile Asp Ser Ala Leu Ala Thr Gln Lys Tyr Ser Val Ala Val Lys 
            100                 105                 110         


Cys Ala Thr Ile Thr Pro Asp Glu Ala Arg Val Glu Glu Phe Lys Leu 
        115                 120                 125             


Lys Lys Met Trp Lys Ser Pro Asn Gly Thr Ile Arg Asn Ile Leu Gly 
    130                 135                 140                 


Gly Thr Val Phe Arg Glu Pro Ile Ile Cys Lys Asn Ile Pro Arg Leu 
145                 150                 155                 160 


Val Pro Gly Trp Thr Lys Pro Ile Thr Ile Gly Arg His Ala His Gly 
                165                 170                 175     


Asp Gln Tyr Lys Ala Thr Asp Phe Val Ala Asp Arg Ala Gly Thr Phe 
            180                 185                 190         


Lys Met Val Phe Thr Pro Lys Asp Gly Ser Gly Val Lys Glu Trp Glu 
        195                 200                 205             


Val Tyr Asn Phe Pro Ala Gly Gly Val Gly Met Gly Met Tyr Asn Thr 
    210                 215                 220                 


Asp Glu Ser Ile Ser Gly Phe Ala His Ser Cys Phe Gln Tyr Ala Ile 
225                 230                 235                 240 


Gln Lys Lys Trp Pro Leu Tyr Met Ser Thr Lys Asn Thr Ile Leu Lys 
                245                 250                 255     


Ala Tyr Asp Gly Arg Phe Lys Asp Ile Phe Gln Glu Ile Phe Asp Lys 
            260                 265                 270         


His Tyr Lys Thr Asp Phe Asp Lys Asn Lys Ile Trp Tyr Glu His Arg 
        275                 280                 285             


Leu Ile Asp Asp Met Val Ala Gln Val Leu Lys Ser Ser Gly Gly Phe 
    290                 295                 300                 


Val Trp Ala Cys Lys Asn Tyr Asp Gly Asp Val Gln Ser Asp Ile Leu 
305                 310                 315                 320 


Ala Gln Gly Phe Gly Ser Leu Gly Leu Met Thr Ser Val Leu Val Cys 
                325                 330                 335     


Pro Asp Gly Lys Thr Ile Glu Ala Glu Ala Ala His Gly Thr Val Thr 
            340                 345                 350         


Arg His Tyr Arg Glu His Gln Lys Gly Arg Pro Thr Ser Thr Asn Pro 
        355                 360                 365             


Ile Ala Ser Ile Phe Ala Trp Thr Arg Gly Leu Glu His Arg Gly Lys 
    370                 375                 380                 


Leu Asp Gly Asn Gln Asp Leu Ile Arg Phe Ala Gln Met Leu Glu Lys 
385                 390                 395                 400 


Val Cys Val Glu Thr Val Glu Ser Gly Ala Met Thr Lys Asp Leu Ala 
                405                 410                 415     


Gly Cys Ile His Gly Leu Ser Asn Val Lys Leu Asn Glu His Phe Leu 
            420                 425                 430         


Asn Thr Thr Asp Phe Leu Asp Thr Ile Lys Ser Asn Leu Asp Arg Ala 
        435                 440                 445             


Leu Gly Arg Gln 
    450         


<210>  142
<211>  416
<212>  PRT
<213>  Escherichia coli

<400>  142

Met Glu Ser Lys Val Val Val Pro Ala Gln Gly Lys Lys Ile Thr Leu 
1               5                   10                  15      


Gln Asn Gly Lys Leu Asn Val Pro Glu Asn Pro Ile Ile Pro Tyr Ile 
            20                  25                  30          


Glu Gly Asp Gly Ile Gly Val Asp Val Thr Pro Ala Met Leu Lys Val 
        35                  40                  45              


Val Asp Ala Ala Val Glu Lys Ala Tyr Lys Gly Glu Arg Lys Ile Ser 
    50                  55                  60                  


Trp Met Glu Ile Tyr Thr Gly Glu Lys Ser Thr Gln Val Tyr Gly Gln 
65                  70                  75                  80  


Asp Val Trp Leu Pro Ala Glu Thr Leu Asp Leu Ile Arg Glu Tyr Arg 
                85                  90                  95      


Val Ala Ile Lys Gly Pro Leu Thr Thr Pro Val Gly Gly Gly Ile Arg 
            100                 105                 110         


Ser Leu Asn Val Ala Leu Arg Gln Glu Leu Asp Leu Tyr Ile Cys Leu 
        115                 120                 125             


Arg Pro Val Arg Tyr Tyr Gln Gly Thr Pro Ser Pro Val Lys His Pro 
    130                 135                 140                 


Glu Leu Thr Asp Met Val Ile Phe Arg Glu Asn Ser Glu Asp Ile Tyr 
145                 150                 155                 160 


Ala Gly Ile Glu Trp Lys Ala Asp Ser Ala Asp Ala Glu Lys Val Ile 
                165                 170                 175     


Lys Phe Leu Arg Glu Glu Met Gly Val Lys Lys Ile Arg Phe Pro Glu 
            180                 185                 190         


His Cys Gly Ile Gly Ile Lys Pro Cys Ser Glu Glu Gly Thr Lys Arg 
        195                 200                 205             


Leu Val Arg Ala Ala Ile Glu Tyr Ala Ile Ala Asn Asp Arg Asp Ser 
    210                 215                 220                 


Val Thr Leu Val His Lys Gly Asn Ile Met Lys Phe Thr Glu Gly Ala 
225                 230                 235                 240 


Phe Lys Asp Trp Gly Tyr Glu Leu Ala Arg Glu Glu Phe Gly Gly Glu 
                245                 250                 255     


Leu Ile Asp Gly Gly Pro Trp Leu Lys Val Lys Asn Pro Asn Thr Gly 
            260                 265                 270         


Lys Glu Ile Val Ile Lys Asp Val Ile Ala Asp Ala Phe Leu Gln Gln 
        275                 280                 285             


Ile Leu Leu Arg Pro Ala Glu Tyr Asp Val Ile Ala Cys Met Asn Leu 
    290                 295                 300                 


Asn Gly Asp Tyr Ile Ser Asp Ala Leu Ala Ala Gln Val Gly Gly Ile 
305                 310                 315                 320 


Gly Ile Ala Pro Gly Ala Asn Ile Gly Asp Glu Cys Ala Leu Phe Glu 
                325                 330                 335     


Ala Thr His Gly Thr Ala Pro Lys Tyr Ala Gly Gln Asp Lys Val Asn 
            340                 345                 350         


Pro Gly Ser Ile Ile Leu Ser Ala Glu Met Met Leu Arg His Met Gly 
        355                 360                 365             


Trp Thr Glu Ala Ala Asp Leu Ile Val Lys Gly Met Glu Gly Ala Ile 
    370                 375                 380                 


Asn Ala Lys Thr Val Thr Tyr Asp Phe Glu Arg Leu Met Glu Gly Ala 
385                 390                 395                 400 


Lys Leu Leu Lys Cys Ser Glu Phe Gly Asp Ala Ile Ile Lys Asn Met 
                405                 410                 415     


<210>  143
<211>  423
<212>  PRT
<213>  Bacillus subtilis

<400>  143

Met Ala Gln Gly Glu Lys Ile Thr Val Ser Asn Gly Val Leu Asn Val 
1               5                   10                  15      


Pro Asn Asn Pro Ile Ile Pro Phe Ile Glu Gly Asp Gly Thr Gly Pro 
            20                  25                  30          


Asp Ile Trp Asn Ala Ala Ser Lys Val Leu Glu Ala Ala Val Glu Lys 
        35                  40                  45              


Ala Tyr Lys Gly Glu Lys Lys Ile Thr Trp Lys Glu Val Tyr Ala Gly 
    50                  55                  60                  


Glu Lys Ala Tyr Asn Lys Thr Gly Glu Trp Leu Pro Ala Glu Thr Leu 
65                  70                  75                  80  


Asp Val Ile Arg Glu Tyr Phe Ile Ala Ile Lys Gly Pro Leu Thr Thr 
                85                  90                  95      


Pro Val Gly Gly Gly Ile Arg Ser Leu Asn Val Ala Leu Arg Gln Glu 
            100                 105                 110         


Leu Asp Leu Phe Val Cys Leu Arg Pro Val Arg Tyr Phe Thr Gly Val 
        115                 120                 125             


Pro Ser Pro Val Lys Arg Pro Glu Asp Thr Asp Met Val Ile Phe Arg 
    130                 135                 140                 


Glu Asn Thr Glu Asp Ile Tyr Ala Gly Ile Glu Tyr Ala Lys Gly Ser 
145                 150                 155                 160 


Glu Glu Val Gln Lys Leu Ile Ser Phe Leu Gln Asn Glu Leu Asn Val 
                165                 170                 175     


Asn Lys Ile Arg Phe Pro Glu Thr Ser Gly Ile Gly Ile Lys Pro Val 
            180                 185                 190         


Ser Glu Glu Gly Thr Ser Arg Leu Val Arg Ala Ala Ile Asp Tyr Ala 
        195                 200                 205             


Ile Glu His Gly Arg Lys Ser Val Thr Leu Val His Lys Gly Asn Ile 
    210                 215                 220                 


Met Lys Phe Thr Glu Gly Ala Phe Lys Asn Trp Gly Tyr Glu Leu Ala 
225                 230                 235                 240 


Glu Lys Glu Tyr Gly Asp Lys Val Phe Thr Trp Ala Gln Tyr Asp Arg 
                245                 250                 255     


Ile Ala Glu Glu Gln Gly Lys Asp Ala Ala Asn Lys Ala Gln Ser Glu 
            260                 265                 270         


Ala Glu Ala Ala Gly Lys Ile Ile Ile Lys Asp Ser Ile Ala Asp Ile 
        275                 280                 285             


Phe Leu Gln Gln Ile Leu Thr Arg Pro Asn Glu Phe Asp Val Val Ala 
    290                 295                 300                 


Thr Met Asn Leu Asn Gly Asp Tyr Ile Ser Asp Ala Leu Ala Ala Gln 
305                 310                 315                 320 


Val Gly Gly Ile Gly Ile Ala Pro Gly Ala Asn Ile Asn Tyr Glu Thr 
                325                 330                 335     


Gly His Ala Ile Phe Glu Ala Thr His Gly Thr Ala Pro Lys Tyr Ala 
            340                 345                 350         


Gly Leu Asp Lys Val Asn Pro Ser Ser Val Ile Leu Ser Gly Val Leu 
        355                 360                 365             


Leu Leu Glu His Leu Gly Trp Asn Glu Ala Ala Asp Leu Val Ile Lys 
    370                 375                 380                 


Ser Met Glu Lys Thr Ile Ala Ser Lys Val Val Thr Tyr Asp Phe Ala 
385                 390                 395                 400 


Arg Leu Met Asp Gly Ala Thr Glu Val Lys Cys Ser Glu Phe Gly Glu 
                405                 410                 415     


Glu Leu Ile Lys Asn Met Asp 
            420             


<210>  144
<211>  366
<212>  PRT
<213>  Homo sapiens

<400>  144

Met Ala Gly Pro Ala Trp Ile Ser Lys Val Ser Arg Leu Leu Gly Ala 
1               5                   10                  15      


Phe His Asn Pro Lys Gln Val Thr Arg Gly Phe Thr Gly Gly Val Gln 
            20                  25                  30          


Thr Val Thr Leu Ile Pro Gly Asp Gly Ile Gly Pro Glu Ile Ser Ala 
        35                  40                  45              


Ala Val Met Lys Ile Phe Asp Ala Ala Lys Ala Pro Ile Gln Trp Glu 
    50                  55                  60                  


Glu Arg Asn Val Thr Ala Ile Gln Gly Pro Gly Gly Lys Trp Met Ile 
65                  70                  75                  80  


Pro Ser Glu Ala Lys Glu Ser Met Asp Lys Asn Lys Met Gly Leu Lys 
                85                  90                  95      


Gly Pro Leu Lys Thr Pro Ile Ala Ala Gly His Pro Ser Met Asn Leu 
            100                 105                 110         


Leu Leu Arg Lys Thr Phe Asp Leu Tyr Ala Asn Val Arg Pro Cys Val 
        115                 120                 125             


Ser Ile Glu Gly Tyr Lys Thr Pro Tyr Thr Asp Val Asn Ile Val Thr 
    130                 135                 140                 


Ile Arg Glu Asn Thr Glu Gly Glu Tyr Ser Gly Ile Glu His Val Ile 
145                 150                 155                 160 


Val Asp Gly Val Val Gln Ser Ile Lys Leu Ile Thr Glu Gly Val Ser 
                165                 170                 175     


Lys Arg Ile Ala Glu Phe Ala Phe Glu Tyr Ala Arg Asn Asn His Arg 
            180                 185                 190         


Ser Asn Val Thr Ala Val His Lys Ala Asn Ile Met Arg Met Ser Asp 
        195                 200                 205             


Gly Leu Phe Leu Gln Lys Cys Arg Glu Val Ala Glu Ser Cys Lys Asp 
    210                 215                 220                 


Ile Lys Phe Asn Glu Met Tyr Leu Asp Thr Val Cys Leu Asn Met Val 
225                 230                 235                 240 


Gln Asp Pro Ser Gln Phe Asp Val Leu Val Met Pro Asn Leu Tyr Gly 
                245                 250                 255     


Asp Ile Leu Ser Asp Leu Cys Ala Gly Leu Ile Gly Gly Leu Gly Val 
            260                 265                 270         


Thr Pro Ser Gly Asn Ile Gly Ala Asn Gly Val Ala Ile Phe Glu Ser 
        275                 280                 285             


Val His Gly Thr Ala Pro Asp Ile Ala Gly Lys Asp Met Ala Asn Pro 
    290                 295                 300                 


Thr Ala Leu Leu Leu Ser Ala Val Met Met Leu Arg His Met Gly Leu 
305                 310                 315                 320 


Phe Asp His Ala Ala Arg Ile Glu Ala Ala Cys Phe Ala Thr Ile Lys 
                325                 330                 335     


Asp Gly Lys Ser Leu Thr Lys Asp Leu Gly Gly Asn Ala Lys Cys Ser 
            340                 345                 350         


Asp Phe Thr Glu Glu Ile Cys Arg Arg Val Lys Asp Leu Asp 
        355                 360                 365     


<210>  145
<211>  362
<212>  PRT
<213>  Schizosaccharomyces pombe

<400>  145

Met Ser Ala Thr Arg Arg Ile Val Leu Gly Leu Ile Pro Ala Asp Gly 
1               5                   10                  15      


Ile Gly Lys Glu Val Val Pro Ala Ala Arg Arg Leu Met Glu Asn Leu 
            20                  25                  30          


Pro Ala Lys His Lys Leu Lys Phe Asp Phe Ile Asp Leu Asp Ala Gly 
        35                  40                  45              


Trp Gly Thr Phe Glu Arg Thr Gly Lys Ala Leu Pro Glu Arg Thr Val 
    50                  55                  60                  


Glu Arg Leu Lys Thr Glu Cys Asn Ala Ala Leu Phe Gly Ala Val Gln 
65                  70                  75                  80  


Ser Pro Thr His Lys Val Ala Gly Tyr Ser Ser Pro Ile Val Ala Leu 
                85                  90                  95      


Arg Lys Lys Met Gly Leu Tyr Ala Asn Val Arg Pro Val Lys Ser Leu 
            100                 105                 110         


Asp Gly Ala Lys Gly Lys Pro Val Asp Leu Val Ile Val Arg Glu Asn 
        115                 120                 125             


Thr Glu Cys Leu Tyr Val Lys Glu Glu Arg Met Val Gln Asn Thr Pro 
    130                 135                 140                 


Gly Lys Arg Val Ala Glu Ala Ile Arg Arg Ile Ser Glu Glu Ala Ser 
145                 150                 155                 160 


Thr Lys Ile Gly Lys Met Ala Phe Glu Ile Ala Lys Ser Arg Gln Lys 
                165                 170                 175     


Ile Arg Glu Ser Gly Thr Tyr Ser Ile His Lys Lys Pro Leu Val Thr 
            180                 185                 190         


Ile Ile His Lys Ser Asn Val Met Ser Val Thr Asp Gly Leu Phe Arg 
        195                 200                 205             


Glu Ser Cys Arg His Ala Gln Ser Leu Asp Pro Ser Tyr Ala Ser Ile 
    210                 215                 220                 


Asn Val Asp Glu Gln Ile Val Asp Ser Met Val Tyr Arg Leu Phe Arg 
225                 230                 235                 240 


Glu Pro Glu Cys Phe Asp Val Val Val Ala Pro Asn Leu Tyr Gly Asp 
                245                 250                 255     


Ile Leu Ser Asp Gly Ala Ala Ser Leu Ile Gly Ser Leu Gly Leu Val 
            260                 265                 270         


Pro Ser Ala Asn Val Gly Asp Asn Phe Val Met Ser Glu Pro Val His 
        275                 280                 285             


Gly Ser Ala Pro Asp Ile Ala Gly Arg Gly Ile Ala Asn Pro Val Ala 
    290                 295                 300                 


Thr Phe Arg Ser Val Ala Leu Met Leu Glu Phe Met Gly His Gln Asp 
305                 310                 315                 320 


Ala Ala Ala Asp Ile Tyr Thr Ala Val Asp Lys Val Leu Thr Glu Gly 
                325                 330                 335     


Lys Val Leu Thr Pro Asp Leu Gly Gly Lys Ser Gly Thr Asn Glu Ile 
            340                 345                 350         


Thr Asp Ala Val Leu Ala Asn Ile His Asn 
        355                 360         


<210>  146
<211>  371
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  146

Met Phe Arg Ser Val Ala Thr Arg Leu Ser Ala Cys Arg Gly Leu Ala 
1               5                   10                  15      


Ser Asn Ala Ala Arg Lys Ser Leu Thr Ile Gly Leu Ile Pro Gly Asp 
            20                  25                  30          


Gly Ile Gly Lys Glu Val Ile Pro Ala Gly Lys Gln Val Leu Glu Asn 
        35                  40                  45              


Leu Asn Ser Lys His Gly Leu Ser Phe Asn Phe Ile Asp Leu Tyr Ala 
    50                  55                  60                  


Gly Phe Gln Thr Phe Gln Glu Thr Gly Lys Ala Leu Pro Asp Glu Thr 
65                  70                  75                  80  


Val Lys Val Leu Lys Glu Gln Cys Gln Gly Ala Leu Phe Gly Ala Val 
                85                  90                  95      


Gln Ser Pro Thr Thr Lys Val Glu Gly Tyr Ser Ser Pro Ile Val Ala 
            100                 105                 110         


Leu Arg Arg Glu Met Gly Leu Phe Ala Asn Val Arg Pro Val Lys Ser 
        115                 120                 125             


Val Glu Gly Glu Lys Gly Lys Pro Ile Asp Met Val Ile Val Arg Glu 
    130                 135                 140                 


Asn Thr Glu Asp Leu Tyr Ile Lys Ile Glu Lys Thr Tyr Ile Asp Lys 
145                 150                 155                 160 


Ala Thr Gly Thr Arg Val Ala Asp Ala Thr Lys Arg Ile Ser Glu Ile 
                165                 170                 175     


Ala Thr Arg Arg Ile Ala Thr Ile Ala Leu Asp Ile Ala Leu Lys Arg 
            180                 185                 190         


Leu Gln Thr Arg Gly Gln Ala Thr Leu Thr Val Thr His Lys Ser Asn 
        195                 200                 205             


Val Leu Ser Gln Ser Asp Gly Leu Phe Arg Glu Ile Cys Lys Glu Val 
    210                 215                 220                 


Tyr Glu Ser Asn Lys Asp Lys Tyr Gly Gln Ile Lys Tyr Asn Glu Gln 
225                 230                 235                 240 


Ile Val Asp Ser Met Val Tyr Arg Leu Phe Arg Glu Pro Gln Cys Phe 
                245                 250                 255     


Asp Val Ile Val Ala Pro Asn Leu Tyr Gly Asp Ile Leu Ser Asp Gly 
            260                 265                 270         


Ala Ala Ala Leu Val Gly Ser Leu Gly Val Val Pro Ser Ala Asn Val 
        275                 280                 285             


Gly Pro Glu Ile Val Ile Gly Glu Pro Cys His Gly Ser Ala Pro Asp 
    290                 295                 300                 


Ile Ala Gly Lys Gly Ile Ala Asn Pro Ile Ala Thr Ile Arg Ser Thr 
305                 310                 315                 320 


Ala Leu Met Leu Glu Phe Leu Gly His Asn Glu Ala Ala Gln Asp Ile 
                325                 330                 335     


Tyr Lys Ala Val Asp Ala Asn Leu Arg Glu Gly Ser Ile Lys Thr Pro 
            340                 345                 350         


Asp Leu Gly Gly Lys Ala Ser Thr Gln Gln Val Val Asp Asp Val Leu 
        355                 360                 365             


Ser Arg Leu 
    370     


<210>  147
<211>  376
<212>  PRT
<213>  Candida albicans

<400>  147

Met Leu Ala Ala Arg Ser Ser Ile Arg Arg Cys Phe Ser Thr Ser Ser 
1               5                   10                  15      


Thr Thr Leu Lys Ser Leu Lys Ile Gly Leu Ile Ser Gly Asp Gly Ile 
            20                  25                  30          


Gly Arg Glu Val Ile Pro Ala Gly Lys Ala Val Leu Glu Asn Leu Pro 
        35                  40                  45              


Ser Lys His Asp Leu Gln Phe Glu Phe Val Asn Leu Asp Ala Gly Phe 
    50                  55                  60                  


Glu Leu Phe Lys Lys Thr Gly Thr Ala Leu Pro Asp Glu Thr Val Asp 
65                  70                  75                  80  


Val Leu Lys Lys Glu Cys Asp Gly Ala Leu Phe Gly Ala Val Ser Ser 
                85                  90                  95      


Pro Thr Thr Lys Val Ala Gly Tyr Ser Ser Pro Ile Val Ala Leu Arg 
            100                 105                 110         


Lys Lys Leu Gly Leu Tyr Ala Asn Val Arg Pro Val Lys Ser Val Glu 
        115                 120                 125             


Gly Ile Gly Arg Pro Val Asp Met Val Ile Val Arg Glu Asn Thr Glu 
    130                 135                 140                 


Asp Leu Tyr Ile Lys Glu Glu Arg Val Tyr Lys Lys Glu Asp Gly Thr 
145                 150                 155                 160 


Lys Val Ala Glu Ala Ile Lys Arg Ile Thr Glu Thr Ala Ser Thr Arg 
                165                 170                 175     


Ile Ala Lys Met Ala Tyr Glu Ile Ala Leu Gln Arg Glu Ala Val Arg 
            180                 185                 190         


Lys Gly Thr Ser Gly Lys Gln Leu His Glu Lys Pro Ser Val Thr Val 
        195                 200                 205             


Thr His Lys Ser Asn Val Leu Ser Gln Ser Asp Gly Leu Phe Arg Glu 
    210                 215                 220                 


Thr Cys Arg Ala Val Tyr Asp Ala Asn Ala Asn Glu Tyr Gly Gly Ile 
225                 230                 235                 240 


Glu Tyr Lys Glu Gln Ile Val Asp Ser Met Val Tyr Arg Met Phe Arg 
                245                 250                 255     


Glu Pro Glu Ile Phe Asp Val Val Val Ala Pro Asn Leu Tyr Gly Asp 
            260                 265                 270         


Ile Leu Ser Asp Gly Ala Ala Ala Leu Val Gly Ser Leu Gly Val Val 
        275                 280                 285             


Pro Ser Ala Asn Val Gly Asp Asn Phe Ala Ile Gly Glu Pro Cys His 
    290                 295                 300                 


Gly Ser Ala Pro Asp Ile Glu Gly Lys Gly Ile Ser Asn Pro Val Ala 
305                 310                 315                 320 


Thr Ile Arg Ser Thr Ala Leu Met Leu Glu Phe Met Gly Tyr Pro Glu 
                325                 330                 335     


Ala Ala Ala Thr Ile Tyr Gln Ala Val Asp Ala Asn Leu Ala Glu Asp 
            340                 345                 350         


Lys Ile Lys Thr Pro Asp Leu Gly Gly Asn Ser Thr Thr Gln Glu Val 
        355                 360                 365             


Ile Asp Asp Ile Ile Arg Arg Phe 
    370                 375     


<210>  148
<211>  334
<212>  PRT
<213>  Thermus thermophilus

<400>  148

Met Ala Tyr Arg Ile Cys Leu Ile Glu Gly Asp Gly Ile Gly His Glu 
1               5                   10                  15      


Val Ile Pro Ala Ala Arg Arg Val Leu Glu Ala Thr Gly Leu Pro Leu 
            20                  25                  30          


Glu Phe Val Glu Ala Glu Ala Gly Trp Glu Thr Phe Glu Arg Arg Gly 
        35                  40                  45              


Thr Ser Val Pro Glu Glu Thr Val Glu Lys Ile Leu Ser Cys His Ala 
    50                  55                  60                  


Thr Leu Phe Gly Ala Ala Thr Ser Pro Thr Arg Lys Val Pro Gly Phe 
65                  70                  75                  80  


Phe Gly Ala Ile Arg Tyr Leu Arg Arg Arg Leu Asp Leu Tyr Ala Asn 
                85                  90                  95      


Val Arg Pro Ala Lys Ser Arg Pro Val Pro Gly Ser Arg Pro Gly Val 
            100                 105                 110         


Asp Leu Val Ile Val Arg Glu Asn Thr Glu Gly Leu Tyr Val Glu Gln 
        115                 120                 125             


Glu Arg Arg Tyr Leu Asp Val Ala Ile Ala Asp Ala Val Ile Ser Lys 
    130                 135                 140                 


Lys Ala Ser Glu Arg Ile Gly Arg Ala Ala Leu Arg Ile Ala Glu Gly 
145                 150                 155                 160 


Arg Pro Arg Lys Thr Leu His Ile Ala His Lys Ala Asn Val Leu Pro 
                165                 170                 175     


Leu Thr Gln Gly Leu Phe Leu Asp Thr Val Lys Glu Val Ala Lys Asp 
            180                 185                 190         


Phe Pro Leu Val Asn Val Gln Asp Ile Ile Val Asp Asn Cys Ala Met 
        195                 200                 205             


Gln Leu Val Met Arg Pro Glu Arg Phe Asp Val Ile Val Thr Thr Asn 
    210                 215                 220                 


Leu Leu Gly Asp Ile Leu Ser Asp Leu Ala Ala Gly Leu Val Gly Gly 
225                 230                 235                 240 


Leu Gly Leu Ala Pro Ser Gly Asn Ile Gly Asp Thr Thr Ala Val Phe 
                245                 250                 255     


Glu Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly Lys Gly Ile Ala 
            260                 265                 270         


Asn Pro Thr Ala Ala Ile Leu Ser Ala Ala Met Met Leu Asp Tyr Leu 
        275                 280                 285             


Gly Glu Lys Glu Ala Ala Lys Arg Val Glu Lys Ala Val Asp Leu Val 
    290                 295                 300                 


Leu Glu Arg Gly Pro Arg Thr Pro Asp Leu Gly Gly Asp Ala Thr Thr 
305                 310                 315                 320 


Glu Ala Phe Thr Glu Ala Val Val Glu Ala Leu Lys Ser Leu 
                325                 330                 


<210>  149
<211>  361
<212>  PRT
<213>  Escherichia coli

<400>  149

Met Met Lys Thr Met Arg Ile Ala Ala Ile Pro Gly Asp Gly Ile Gly 
1               5                   10                  15      


Lys Glu Val Leu Pro Glu Gly Ile Arg Val Leu Gln Ala Ala Ala Glu 
            20                  25                  30          


Arg Trp Gly Phe Ala Leu Ser Phe Glu Gln Met Glu Trp Ala Ser Cys 
        35                  40                  45              


Glu Tyr Tyr Ser His His Gly Lys Met Met Pro Asp Asp Trp His Glu 
    50                  55                  60                  


Gln Leu Ser Arg Phe Asp Ala Ile Tyr Phe Gly Ala Val Gly Trp Pro 
65                  70                  75                  80  


Asp Thr Val Pro Asp His Ile Ser Leu Trp Gly Ser Leu Leu Lys Phe 
                85                  90                  95      


Arg Arg Glu Phe Asp Gln Tyr Val Asn Leu Arg Pro Val Arg Leu Phe 
            100                 105                 110         


Pro Gly Val Pro Cys Pro Leu Ala Gly Lys Gln Pro Gly Asp Ile Asp 
        115                 120                 125             


Phe Tyr Val Val Arg Glu Asn Thr Glu Gly Glu Tyr Ser Ser Leu Gly 
    130                 135                 140                 


Gly Arg Val Asn Glu Gly Thr Glu His Glu Val Val Ile Gln Glu Ser 
145                 150                 155                 160 


Val Phe Thr Arg Arg Gly Val Asp Arg Ile Leu Arg Tyr Ala Phe Glu 
                165                 170                 175     


Leu Ala Gln Ser Arg Pro Arg Lys Thr Leu Thr Ser Ala Thr Lys Ser 
            180                 185                 190         


Asn Gly Leu Ala Ile Ser Met Pro Tyr Trp Asp Glu Arg Val Glu Ala 
        195                 200                 205             


Met Ala Glu Asn Tyr Pro Glu Ile Arg Trp Asp Lys Gln His Ile Asp 
    210                 215                 220                 


Ile Leu Cys Ala Arg Phe Val Met Gln Pro Glu Arg Phe Asp Val Val 
225                 230                 235                 240 


Val Ala Ser Asn Leu Phe Gly Asp Ile Leu Ser Asp Leu Gly Pro Ala 
                245                 250                 255     


Cys Thr Gly Thr Ile Gly Ile Ala Pro Ser Ala Asn Leu Asn Pro Glu 
            260                 265                 270         


Arg Thr Phe Pro Ser Leu Phe Glu Pro Val His Gly Ser Ala Pro Asp 
        275                 280                 285             


Ile Tyr Gly Lys Asn Ile Ala Asn Pro Ile Ala Thr Ile Trp Ala Gly 
    290                 295                 300                 


Ala Met Met Leu Asp Phe Leu Gly Asn Gly Asp Glu Arg Phe Gln Gln 
305                 310                 315                 320 


Ala His Asn Gly Ile Leu Ala Val Ile Glu Glu Val Ile Ala His Gly 
                325                 330                 335     


Pro Lys Thr Pro Asp Met Lys Gly Ser Ala Thr Thr Pro Gln Val Ala 
            340                 345                 350         


Asp Ala Ile Cys Lys Ile Ile Leu Arg 
        355                 360     


<210>  150
<211>  363
<212>  PRT
<213>  Pseudomonas putida

<400>  150

Met Ser Lys Pro Phe Arg Ile Ala Ala Ile Pro Gly Asp Gly Ile Gly 
1               5                   10                  15      


Asn Glu Val Leu Pro Glu Gly Ile Arg Val Val Glu Ala Ala Ala Arg 
            20                  25                  30          


Lys His Gly Leu Asp Ile Ser Phe Glu Phe Phe Glu Trp Ala Ser Cys 
        35                  40                  45              


Asp Tyr Tyr Leu Ala His Gly Lys Met Met Pro Asp Asp Trp Phe Glu 
    50                  55                  60                  


Gln Leu Lys Gly Phe Asp Ala Leu Tyr Phe Gly Ala Val Gly Trp Pro 
65                  70                  75                  80  


Asp Lys Val Pro Asp His Ile Ser Leu Trp Gly Ser Leu Leu Lys Phe 
                85                  90                  95      


Arg Arg Asp Phe Asp Gln Tyr Val Asn Ile Arg Pro Val Arg Leu Phe 
            100                 105                 110         


Pro Gly Val Pro Cys Pro Leu Ala Gly Arg Glu Pro Gly Asp Ile Asp 
        115                 120                 125             


Phe Val Val Ile Arg Glu Asn Thr Glu Gly Glu Tyr Ser Ser Leu Gly 
    130                 135                 140                 


Gly Arg Met Phe Glu Gly Thr Glu Asn Glu Phe Val Leu Gln Glu Ser 
145                 150                 155                 160 


Val Phe Thr Arg Arg Gly Val Asp Arg Ile Leu Lys Tyr Ala Phe Asp 
                165                 170                 175     


Val Ala Gln Thr Arg Glu Arg Lys His Val Thr Ser Ala Thr Lys Ser 
            180                 185                 190         


Asn Gly Met Ala Val Ser Met Pro Tyr Trp Asp Glu Arg Thr Ala Ala 
        195                 200                 205             


Met Ala Ala Asn Tyr Pro Glu Ile Ser Trp Asp Lys Gln His Ile Asp 
    210                 215                 220                 


Ile Leu Cys Ala Arg Phe Val Leu Gln Pro Asp Arg Phe Asp Val Val 
225                 230                 235                 240 


Val Ala Ser Asn Leu Phe Gly Asp Ile Leu Ser Asp Leu Gly Pro Ala 
                245                 250                 255     


Cys Ala Gly Thr Ile Gly Ile Ala Pro Ser Ala Asn Leu Asn Pro Glu 
            260                 265                 270         


Arg Lys Phe Pro Ser Leu Phe Glu Pro Val His Gly Ser Ala Pro Asp 
        275                 280                 285             


Ile Tyr Gly Lys Asn Ile Ala Asn Pro Ile Ala Met Ile Trp Ser Gly 
    290                 295                 300                 


Ala Leu Met Leu Asp Phe Leu Gly Asn Asp Gly Ala Asp Pro Arg Tyr 
305                 310                 315                 320 


Arg Ala Ala His Asp Asp Ile Leu Lys Ala Ile Glu Gln Val Ile Ala 
                325                 330                 335     


Ala Gly Asp Val Thr Arg Asp Met Gly Gly Gln Gln Ser Thr Gln Gln 
            340                 345                 350         


Val Gly Gln Ala Ile Thr Ala Leu Val Glu Ala 
        355                 360             


<210>  151
<211>  345
<212>  PRT
<213>  Thermus thermophilus

<400>  151

Met Lys Val Ala Val Leu Pro Gly Asp Gly Ile Gly Pro Glu Val Thr 
1               5                   10                  15      


Glu Ala Ala Leu Lys Val Leu Arg Ala Leu Asp Glu Ala Glu Gly Leu 
            20                  25                  30          


Gly Leu Ala Tyr Glu Val Phe Pro Phe Gly Gly Ala Ala Ile Asp Ala 
        35                  40                  45              


Phe Gly Glu Pro Phe Pro Glu Pro Thr Arg Lys Gly Val Glu Glu Ala 
    50                  55                  60                  


Glu Ala Val Leu Leu Gly Ser Val Gly Gly Pro Lys Trp Asp Gly Leu 
65                  70                  75                  80  


Pro Arg Lys Ile Arg Pro Glu Thr Gly Leu Leu Ser Leu Arg Lys Ser 
                85                  90                  95      


Gln Asp Leu Phe Ala Asn Leu Arg Pro Ala Lys Val Phe Pro Gly Leu 
            100                 105                 110         


Glu Arg Leu Ser Pro Leu Lys Glu Glu Ile Ala Arg Gly Val Asp Val 
        115                 120                 125             


Leu Ile Val Arg Glu Leu Thr Gly Gly Ile Tyr Phe Gly Glu Pro Arg 
    130                 135                 140                 


Gly Met Ser Glu Ala Glu Ala Trp Asn Thr Glu Arg Tyr Ser Lys Pro 
145                 150                 155                 160 


Glu Val Glu Arg Val Ala Arg Val Ala Phe Glu Ala Ala Arg Lys Arg 
                165                 170                 175     


Arg Lys His Val Val Ser Val Asp Lys Ala Asn Val Leu Glu Val Gly 
            180                 185                 190         


Glu Phe Trp Arg Lys Thr Val Glu Glu Val Gly Arg Gly Tyr Pro Asp 
        195                 200                 205             


Val Ala Leu Glu His Gln Tyr Val Asp Ala Met Ala Met His Leu Val 
    210                 215                 220                 


Arg Ser Pro Ala Arg Phe Asp Val Val Val Thr Gly Asn Ile Phe Gly 
225                 230                 235                 240 


Asp Ile Leu Ser Asp Leu Ala Ser Val Leu Pro Gly Ser Leu Gly Leu 
                245                 250                 255     


Leu Pro Ser Ala Ser Leu Gly Arg Gly Thr Pro Val Phe Glu Pro Val 
            260                 265                 270         


His Gly Ser Ala Pro Asp Ile Ala Gly Lys Gly Ile Ala Asn Pro Thr 
        275                 280                 285             


Ala Ala Ile Leu Ser Ala Ala Met Met Leu Glu His Ala Phe Gly Leu 
    290                 295                 300                 


Val Glu Leu Ala Arg Lys Val Glu Asp Ala Val Ala Lys Ala Leu Leu 
305                 310                 315                 320 


Glu Thr Pro Pro Pro Asp Leu Gly Gly Ser Ala Gly Thr Glu Ala Phe 
                325                 330                 335     


Thr Ala Thr Val Leu Arg His Leu Ala 
            340                 345 


<210>  152
<211>  358
<212>  PRT
<213>  Acidithiobacillus ferrooxidans

<400>  152

Met Lys Lys Ile Ala Ile Phe Ala Gly Asp Gly Ile Gly Pro Glu Ile 
1               5                   10                  15      


Val Ala Ala Ala Arg Gln Val Leu Asp Ala Val Asp Gln Ala Ala Arg 
            20                  25                  30          


Leu Gly Leu His Cys Ser Glu Gly Leu Val Gly Gly Ala Ala Leu Asp 
        35                  40                  45              


Ala Ser Asp Asp Pro Leu Pro Ala Ala Ser Leu Gln Leu Ala Leu Glu 
    50                  55                  60                  


Ala Asp Ala Val Ile Leu Gly Ala Val Gly Gly Pro Arg Trp Asp Ala 
65                  70                  75                  80  


Tyr Pro Pro Ala Lys Arg Pro Glu Gln Gly Leu Leu Arg Leu Arg Lys 
                85                  90                  95      


Gly Leu Asp Leu Tyr Ala Asn Leu Arg Pro Ala Gln Ile Phe Pro Gln 
            100                 105                 110         


Leu Leu Asp Ala Ser Pro Leu Arg Pro Glu Leu Val Arg Asp Val Asp 
        115                 120                 125             


Ile Leu Val Val Arg Glu Leu Thr Gly Asp Ile Tyr Phe Gly Gln Pro 
    130                 135                 140                 


Arg Gly Leu Glu Val Val Asp Gly Lys Arg Arg Gly Phe Asn Thr Met 
145                 150                 155                 160 


Val Tyr Asp Glu Asp Glu Ile Arg Arg Ile Ala His Val Ala Phe Arg 
                165                 170                 175     


Ala Ala Gln Gly Arg Arg Lys Gln Leu Cys Ser Val Asp Lys Ala Asn 
            180                 185                 190         


Val Leu Glu Thr Thr Arg Leu Trp Arg Glu Val Val Thr Glu Val Ala 
        195                 200                 205             


Gln Asp Tyr Pro Asp Val Gln Leu Ser His Met Tyr Val Asp Asn Ala 
    210                 215                 220                 


Ala Met Gln Leu Ile Arg Ala Pro Ala Gln Phe Asp Val Leu Leu Thr 
225                 230                 235                 240 


Gly Asn Met Phe Gly Asp Ile Leu Ser Asp Glu Ala Ser Gln Leu Thr 
                245                 250                 255     


Gly Ser Ile Gly Met Leu Pro Ser Ala Ser Leu Gly Glu Gly Arg Ala 
            260                 265                 270         


Met Tyr Glu Pro Ile His Gly Ser Ala Pro Asp Ile Ala Gly Gln Asp 
        275                 280                 285             


Lys Ala Asn Pro Leu Ala Thr Ile Leu Ser Val Ala Met Met Leu Arg 
    290                 295                 300                 


Tyr Ser Leu Gly Ala Glu Leu Trp Ala Gln Arg Val Glu Ala Ala Val 
305                 310                 315                 320 


Gln Arg Val Leu Asp Gln Gly Leu Arg Thr Ala Asp Ile Ala Ala Pro 
                325                 330                 335     


Gly Ala Pro Val Ile Gly Thr Lys Ala Met Gly Ala Ala Val Val Asp 
            340                 345                 350         


Ala Leu Asn Phe Lys Asp 
        355             


<210>  153
<211>  364
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  153

Met Ser Gly Pro Lys Lys Ile Val Val Leu Pro Gly Asp His Val Gly 
1               5                   10                  15      


Gln Glu Ile Thr Ala Glu Ala Ile Lys Val Leu Lys Ala Ile Ser Asp 
            20                  25                  30          


Val Arg Ser Asn Val Lys Phe Asp Phe Glu Asn His Leu Ile Gly Gly 
        35                  40                  45              


Ala Ala Ile Asp Ala Thr Gly Val Pro Leu Pro Asp Glu Ala Leu Glu 
    50                  55                  60                  


Ala Ser Lys Lys Ala Asp Ala Val Leu Leu Gly Ala Val Gly Gly Pro 
65                  70                  75                  80  


Lys Trp Gly Thr Gly Ser Val Arg Pro Glu Gln Gly Leu Leu Lys Ile 
                85                  90                  95      


Arg Lys Glu Leu Gln Leu Tyr Ala Asn Leu Arg Pro Cys Asn Phe Ala 
            100                 105                 110         


Ser Asp Ser Leu Leu Asp Leu Ser Pro Ile Lys Pro Gln Phe Ala Lys 
        115                 120                 125             


Gly Thr Asp Phe Val Val Val Arg Glu Leu Val Gly Gly Ile Tyr Phe 
    130                 135                 140                 


Gly Lys Arg Lys Glu Asp Asp Gly Asp Gly Val Ala Trp Asp Ser Glu 
145                 150                 155                 160 


Gln Tyr Thr Val Pro Glu Val Gln Arg Ile Thr Arg Met Ala Ala Phe 
                165                 170                 175     


Met Ala Leu Gln His Glu Pro Pro Leu Pro Ile Trp Ser Leu Asp Lys 
            180                 185                 190         


Ala Asn Val Leu Ala Ser Ser Arg Leu Trp Arg Lys Thr Val Glu Glu 
        195                 200                 205             


Thr Ile Lys Asn Glu Phe Pro Thr Leu Lys Val Gln His Gln Leu Ile 
    210                 215                 220                 


Asp Ser Ala Ala Met Ile Leu Val Lys Asn Pro Thr His Leu Asn Gly 
225                 230                 235                 240 


Ile Ile Ile Thr Ser Asn Met Phe Gly Asp Ile Ile Ser Asp Glu Ala 
                245                 250                 255     


Ser Val Ile Pro Gly Ser Leu Gly Leu Leu Pro Ser Ala Ser Leu Ala 
            260                 265                 270         


Ser Leu Pro Asp Lys Asn Thr Ala Phe Gly Leu Tyr Glu Pro Cys His 
        275                 280                 285             


Gly Ser Ala Pro Asp Leu Pro Lys Asn Lys Val Asn Pro Ile Ala Thr 
    290                 295                 300                 


Ile Leu Ser Ala Ala Met Met Leu Lys Leu Ser Leu Asn Leu Pro Glu 
305                 310                 315                 320 


Glu Gly Lys Ala Ile Glu Asp Ala Val Lys Lys Val Leu Asp Ala Gly 
                325                 330                 335     


Ile Arg Thr Gly Asp Leu Gly Gly Ser Asn Ser Thr Thr Glu Val Gly 
            340                 345                 350         


Asp Ala Val Ala Glu Glu Val Lys Lys Ile Leu Ala 
        355                 360                 


<210>  154
<211>  1053
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  154
atgaaatcac tcactattgg tcttatcccc ggtgacggta tcggtaagga agtcattcct       60

gctggtaagc aagttttgga aaaccttaac tccaagcacg gcctaagctt caactttatt      120

gatctctacg ccggtttcca aacattccaa gaaacaggaa aggcgttgcc tgatgagact      180

gttaaagtgt tgaaggaaca atgtcaaggt gctcttttcg gtgcagttca gtctccaact      240

actaaggtgg aaggttactc ctcaccaatt gttgctctaa ggagggaaat gggccttttc      300

gctaatgttc gtcctgttaa gtctgtagag ggagaaaagg gtaaaccaat tgacatggtt      360

atcgtctgtg aaaatactga ggacctgtac attaaaattg aaaaaacata cattgacaag      420

gccacaggta caagagttgc tgatgccaca aagagaatat ccgaaattgc aacaagaaga      480

attgcaacca ttgcattaga tattgccttg aaaagattac aaacaagagg ccaagccact      540

ttgacagtga ctcataaatc aaatgttcta tctcaaagtg atggtctatt cagagaaatc      600

tgtaaggaag tctacgaatc taacaaggac aagtacggtc aaatcaaata taacgaacaa      660

attgtggatt ccatggttta taggctgttc agagaaccac aatgttttga tgtgatagtg      720

gcaccaaacc tatacgggga tatattatct gacggtgctg ctgctttagt cggttcatta      780

ggtgttgttc caagcgccaa cgtaggtcca gaaattgtca ttggtgaacc atgccatggt      840

tctgcaccag atattgctgg taaaggtatt gctaacccaa tcgccactat aagatctact      900

gctttgatgt tggaattctt gggccacaac gaagctgccc aagatatcta caaggctgtt      960

gatgctaact taagagaggg ttctatcaag acaccagatt taggtggtaa ggcttctact     1020

caacaagtcg ttgacgacgt tttgtcgaga tta                                  1053


<210>  155
<211>  351
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  155

Met Lys Ser Leu Thr Ile Gly Leu Ile Pro Gly Asp Gly Ile Gly Lys 
1               5                   10                  15      


Glu Val Ile Pro Ala Gly Lys Gln Val Leu Glu Asn Leu Asn Ser Lys 
            20                  25                  30          


His Gly Leu Ser Phe Asn Phe Ile Asp Leu Tyr Ala Gly Phe Gln Thr 
        35                  40                  45              


Phe Gln Glu Thr Gly Lys Ala Leu Pro Asp Glu Thr Val Lys Val Leu 
    50                  55                  60                  


Lys Glu Gln Cys Gln Gly Ala Leu Phe Gly Ala Val Gln Ser Pro Thr 
65                  70                  75                  80  


Thr Lys Val Glu Gly Tyr Ser Ser Pro Ile Val Ala Leu Arg Arg Glu 
                85                  90                  95      


Met Gly Leu Phe Ala Asn Val Arg Pro Val Lys Ser Val Glu Gly Glu 
            100                 105                 110         


Lys Gly Lys Pro Ile Asp Met Val Ile Val Cys Glu Asn Thr Glu Asp 
        115                 120                 125             


Leu Tyr Ile Lys Ile Glu Lys Thr Tyr Ile Asp Lys Ala Thr Gly Thr 
    130                 135                 140                 


Arg Val Ala Asp Ala Thr Lys Arg Ile Ser Glu Ile Ala Thr Arg Arg 
145                 150                 155                 160 


Ile Ala Thr Ile Ala Leu Asp Ile Ala Leu Lys Arg Leu Gln Thr Arg 
                165                 170                 175     


Gly Gln Ala Thr Leu Thr Val Thr His Lys Ser Asn Val Leu Ser Gln 
            180                 185                 190         


Ser Asp Gly Leu Phe Arg Glu Ile Cys Lys Glu Val Tyr Glu Ser Asn 
        195                 200                 205             


Lys Asp Lys Tyr Gly Gln Ile Lys Tyr Asn Glu Gln Ile Val Asp Ser 
    210                 215                 220                 


Met Val Tyr Arg Leu Phe Arg Glu Pro Gln Cys Phe Asp Val Ile Val 
225                 230                 235                 240 


Ala Pro Asn Leu Tyr Gly Asp Ile Leu Ser Asp Gly Ala Ala Ala Leu 
                245                 250                 255     


Val Gly Ser Leu Gly Val Val Pro Ser Ala Asn Val Gly Pro Glu Ile 
            260                 265                 270         


Val Ile Gly Glu Pro Cys His Gly Ser Ala Pro Asp Ile Ala Gly Lys 
        275                 280                 285             


Gly Ile Ala Asn Pro Ile Ala Thr Ile Arg Ser Thr Ala Leu Met Leu 
    290                 295                 300                 


Glu Phe Leu Gly His Asn Glu Ala Ala Gln Asp Ile Tyr Lys Ala Val 
305                 310                 315                 320 


Asp Ala Asn Leu Arg Glu Gly Ser Ile Lys Thr Pro Asp Leu Gly Gly 
                325                 330                 335     


Lys Ala Ser Thr Gln Gln Val Val Asp Asp Val Leu Ser Arg Leu 
            340                 345                 350     


<210>  156
<211>  972
<212>  DNA
<213>  Acidaminococcus fermentans

<400>  156
ggatccatga gtaaagtaat gacgttaaaa gacgcaatcg ccaagtatgt gcacagtggt       60

gatcacattg ctctgggtgg ttttacgacg gaccgtaaac cctatgcggc tgtgttcgaa      120

atcctgagac agggtatcac ggatctgacc ggtctgggcg gcgctgccgg cggcgactgg      180

gatatgctga tcggcaacgg ccgtgtgaaa gcctacatca actgctacac cgccaactcc      240

ggtgtgacca acgtttccag acggttcaga aaatggttcg aagccggcaa actgaccatg      300

gaagactatt cccaggatgt tatctacatg atgtggcatg ccgccgctct gggcctgccc      360

ttcctgcctg taaccctgat gcagggctcc ggcctgaccg atgaatgggg catcagcaag      420

gaagtccgta aaaccctgga caaagttcct gatgacaaat tcaaatacat cgacaacccc      480

ttcaaaccgg gtgaaaaagt cgtggctgtt cctgttccgc aggttgatgt ggccatcatc      540

catgcccagc aggcttctcc cgatggcacc gttcgcatct ggggcggcaa attccaggat      600

gtggatattg ctgaagcagc caaatacacc atcgttacct gcgaagaaat catttctgat      660

gaagaaatca gaagagatcc caccaagaac gatatccccg gcatgtgcgt agatgctgtt      720

gtcctggctc cttacggtgc acatccttct cagtgctatg gcctgtacga ctacgacaat      780

ccgttcctga aagtctatga caaggtctcc aagacccagg aagacttcga tgccttctgc      840

aaggaatggg tgttcgacct gaaggatcat gacgaatacc tgaacaaact gggtgccact      900

cgtctgatca acctgaaggt tgttcctggt ctgggctacc acatcgacat gacgaaggag      960

gacaaagtcg ac                                                          972


<210>  157
<211>  972
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized glutaconate CoA-transferase subunit A 
       polynucleotide

<400>  157
ggatccatgt caaaagttat gacattaaag gacgctattg ctaaatacgt ccactcaggt       60

gaccacatag ctttgggtgg tttcacaact gacaggaagc cttacgctgc agtcttcgag      120

attttgaggc agggtattac tgacttgact ggtttgggtg gtgctgcagg tggtgactgg      180

gacatgttga taggaaacgg aagggttaag gcatacataa actgttacac agcaaactca      240

ggtgtcacaa acgtctctag gaggttcagg aagtggttcg aggctggtaa gttgacaatg      300

gaagattatt cacaggatgt tatttacatg atgtggcacg cagcagcatt gggtttgcct      360

ttcttgcctg tcacattgat gcagggatca ggtttgactg acgagtgggg tatttctaag      420

gaggttagaa agactttgga taaagtccct gacgacaagt tcaagtatat agacaaccca      480

ttcaagccag gtgagaaggt cgtcgctgtc ccagtcccac aagttgacgt cgctattatt      540

cacgctcagc aggcatctcc agacggaact gtcaggatat ggggaggtaa gttccaggac      600

gttgacattg cagaggcagc aaagtacaca attgtcacat gcgaggaaat aatttctgac      660

gaggagataa ggagggaccc tacaaagaat gacattcctg gaatgtgcgt tgacgcagtc      720

gtcttggctc catatggtgc acacccatca cagtgctacg gtttgtacga ctacgataac      780

ccttttttga aggtctacga caaagtctca aagactcagg aagacttcga cgctttctgc      840

aaggaatggg tcttcgactt gaaggatcac gacgagtatt tgaacaagtt aggagcaaca      900

aggttaataa acttgaaagt cgtcccaggt ttgggttacc acatagacat gactaaggaa      960

gacaaggtcg ac                                                          972


<210>  158
<211>  322
<212>  PRT
<213>  Acidaminococcus fermentans

<400>  158

Met Ser Lys Val Met Thr Leu Lys Asp Ala Ile Ala Lys Tyr Val His 
1               5                   10                  15      


Ser Gly Asp His Ile Ala Leu Gly Gly Phe Thr Thr Asp Arg Lys Pro 
            20                  25                  30          


Tyr Ala Ala Val Phe Glu Ile Leu Arg Gln Gly Ile Thr Asp Leu Thr 
        35                  40                  45              


Gly Leu Gly Gly Ala Ala Gly Gly Asp Trp Asp Met Leu Ile Gly Asn 
    50                  55                  60                  


Gly Arg Val Lys Ala Tyr Ile Asn Cys Tyr Thr Ala Asn Ser Gly Val 
65                  70                  75                  80  


Thr Asn Val Ser Arg Arg Phe Arg Lys Trp Phe Glu Ala Gly Lys Leu 
                85                  90                  95      


Thr Met Glu Asp Tyr Ser Gln Asp Val Ile Tyr Met Met Trp His Ala 
            100                 105                 110         


Ala Ala Leu Gly Leu Pro Phe Leu Pro Val Thr Leu Met Gln Gly Ser 
        115                 120                 125             


Gly Leu Thr Asp Glu Trp Gly Ile Ser Lys Glu Val Arg Lys Thr Leu 
    130                 135                 140                 


Asp Lys Val Pro Asp Asp Lys Phe Lys Tyr Ile Asp Asn Pro Phe Lys 
145                 150                 155                 160 


Pro Gly Glu Lys Val Val Ala Val Pro Val Pro Gln Val Asp Val Ala 
                165                 170                 175     


Ile Ile His Ala Gln Gln Ala Ser Pro Asp Gly Thr Val Arg Ile Trp 
            180                 185                 190         


Gly Gly Lys Phe Gln Asp Val Asp Ile Ala Glu Ala Ala Lys Tyr Thr 
        195                 200                 205             


Ile Val Thr Cys Glu Glu Ile Ile Ser Asp Glu Glu Ile Arg Arg Asp 
    210                 215                 220                 


Pro Thr Lys Asn Asp Ile Pro Gly Met Cys Val Asp Ala Val Val Leu 
225                 230                 235                 240 


Ala Pro Tyr Gly Ala His Pro Ser Gln Cys Tyr Gly Leu Tyr Asp Tyr 
                245                 250                 255     


Asp Asn Pro Phe Leu Lys Val Tyr Asp Lys Val Ser Lys Thr Gln Glu 
            260                 265                 270         


Asp Phe Asp Ala Phe Cys Lys Glu Trp Val Phe Asp Leu Lys Asp His 
        275                 280                 285             


Asp Glu Tyr Leu Asn Lys Leu Gly Ala Thr Arg Leu Ile Asn Leu Lys 
    290                 295                 300                 


Val Val Pro Gly Leu Gly Tyr His Ile Asp Met Thr Lys Glu Asp Lys 
305                 310                 315                 320 


Val Asp 
        


<210>  159
<211>  814
<212>  DNA
<213>  Acidaminococcus fermentans

<400>  159
gcggccgcat ggctgattac acgaattata ccaataaaga aatgcaggct gtgaccattg       60

ccaagcagat caaaaatggt caggttgtaa cggttggtac cggtctgcct ctgatcggcg      120

ccagcgtggc caagagagtc tatgctcctg actgccacat catcgtggaa agcggtctga      180

tggactgctc cccggtggaa gttccccgtt ccgtaggtga cctgcggttc atggctcact      240

gcggctgcat ctggccgaac gtccggttcg tgggcttcga aatcaacgaa tacctgcaca      300

aggccaaccg tctgatcgcc ttcatcggcg gggcccagat cgatccgtac ggcaacgtga      360

actccacttc catcggtgat taccatcatc cgaaaacccg tttcaccggg tccggcggtg      420

ccaacggcat tgccacctac tccaacacca tcatcatgat gcagcatgaa aaacgcagat      480

tcatgaacaa aatcgactac gtgaccagcc cgggctggat cgacggccct ggcggacggg      540

aaagactggg tctgcccggc gatgtgggac ctcagctggt agtaaccgat aaagggatcc      600

tgaaattcga cgaaaagacc aaacggatgt acctggctgc ctactatccc acttcttctc      660

cggaagatgt actggaaaac accgggttcg acctggatgt atccaaggct gtggaactgg      720

aagctccgga tccggccgtc atcaaactga tccgtgaaga aatcgatccg gggcaggcct      780

ttatccaggt ccccacggaa gcaaaagcac tagt                                  814


<210>  160
<211>  814
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized gctB glutaconate CoA-transferase subunit B 
       polynucleotide

<400>  160
gcggccgcat ggctgattat acaaactaca caaacaagga gatgcaggca gttacaattg       60

caaaacagat taagaacggt caggtcgtta cagtcggtac tggattgcca ttgattggtg      120

catcagtcgc taagagggtc tacgcaccag actgccacat tattgtcgag tcaggtttga      180

tggactgctc accagtcgag gtcccaaggt cagtcggtga tttgaggttc atggctcact      240

gcggttgcat ttggccaaac gtcaggttcg tcggtttcga gattaatgag tacttgcaca      300

aggcaaacag attgattgca ttcattggtg gtgctcagat agacccatac ggtaatgtca      360

attctacttc aattggtgac taccatcacc ctaagactag gttcactgga tctggtggtg      420

ctaacggtat agcaacttac tctaacacaa taataatgat gcaacatgag aagagaaggt      480

tcatgaataa gattgattac gtcacatcac caggttggat tgacggacca ggtggtaggg      540

agagattggg attgccaggt gacgtcggtc cacagttggt tgtcactgac aagggaattt      600

taaagttcga cgaaaagact aagagaatgt atttggcagc atactaccca acttcttctc      660

ctgaggacgt cttggagaac actggtttcg acttggatgt ctcaaaggca gtcgaattag      720

aggctcctga cccagcagtc ataaagttga taagggagga gattgaccct ggtcaggctt      780

tcatacaggt cccaactgaa gctaaggcac tagt                                  814


<210>  161
<211>  268
<212>  PRT
<213>  Acidaminococcus fermentans

<400>  161

Met Ala Asp Tyr Thr Asn Tyr Thr Asn Lys Glu Met Gln Ala Val Thr 
1               5                   10                  15      


Ile Ala Lys Gln Ile Lys Asn Gly Gln Val Val Thr Val Gly Thr Gly 
            20                  25                  30          


Leu Pro Leu Ile Gly Ala Ser Val Ala Lys Arg Val Tyr Ala Pro Asp 
        35                  40                  45              


Cys His Ile Ile Val Glu Ser Gly Leu Met Asp Cys Ser Pro Val Glu 
    50                  55                  60                  


Val Pro Arg Ser Val Gly Asp Leu Arg Phe Met Ala His Cys Gly Cys 
65                  70                  75                  80  


Ile Trp Pro Asn Val Arg Phe Val Gly Phe Glu Ile Asn Glu Tyr Leu 
                85                  90                  95      


His Lys Ala Asn Arg Leu Ile Ala Phe Ile Gly Gly Ala Gln Ile Asp 
            100                 105                 110         


Pro Tyr Gly Asn Val Asn Ser Thr Ser Ile Gly Asp Tyr His His Pro 
        115                 120                 125             


Lys Thr Arg Phe Thr Gly Ser Gly Gly Ala Asn Gly Ile Ala Thr Tyr 
    130                 135                 140                 


Ser Asn Thr Ile Ile Met Met Gln His Glu Lys Arg Arg Phe Met Asn 
145                 150                 155                 160 


Lys Ile Asp Tyr Val Thr Ser Pro Gly Trp Ile Asp Gly Pro Gly Gly 
                165                 170                 175     


Arg Glu Arg Leu Gly Leu Pro Gly Asp Val Gly Pro Gln Leu Val Val 
            180                 185                 190         


Thr Asp Lys Gly Ile Leu Lys Phe Asp Glu Lys Thr Lys Arg Met Tyr 
        195                 200                 205             


Leu Ala Ala Tyr Tyr Pro Thr Ser Ser Pro Glu Asp Val Leu Glu Asn 
    210                 215                 220                 


Thr Gly Phe Asp Leu Asp Val Ser Lys Ala Val Glu Leu Glu Ala Pro 
225                 230                 235                 240 


Asp Pro Ala Val Ile Lys Leu Ile Arg Glu Glu Ile Asp Pro Gly Gln 
                245                 250                 255     


Ala Phe Ile Gln Val Pro Thr Glu Ala Lys Ala Leu 
            260                 265             


<210>  162
<211>  1452
<212>  DNA
<213>  Clostridium symbiosum

<400>  162
ggatccatgg caaaacaagt tagtcctggc gttctcgcac ttcgcaaggt cgttgatgac       60

gtacacaaag aggcgcgcga ggccaaagca agaggcgagt tagtcggctg gtcctcatcc      120

aagttccctt gtgagcttgc agcagctttt gatctgaatg ttatgtatcc ggagaaccag      180

gctgccggca tcgctgcaaa ccgttacggt gagatgatgt gccaggccgc tgaggatctt      240

ggctatgaca acgatatctg cggatatgcc cgtatcagtc tggcttatgc agccggtgtg      300

cgtgtatcac gcaaatatga tgctgaaacc ggtgaataca tcatcgatcc tgctacaggc      360

aaaccgttaa aagacgcaga aggcaatgtg gtaatcgacg aagcaaccgg taaaccaaag      420

aaagatccaa agacacagac tccttatctt gtactggaca atctgcttga gattgaagct      480

cttccggacg gcccggagaa agaaagacgt ctggaggcaa tctctccaat ccgtcagatg      540

cgtattccgc agccggactt cgttctctgc tgtaacaata tctgcaactg tatgaccaaa      600

tggtatgaga atattgcccg tatgtgcaac gtaccgctga tcatgattga tattccgtat      660

aacaatacag tagaggttca tgacgataat gtaaaatatg tacgcgctca gttcgataag      720

gcaattaagc agttagaaga actcacaggc aagaaatttg acgagaagaa gtttgaaaaa      780

gcctgttcca atgctaaccg taccgcacag gcatggttaa aggtttgcga ttatcttcag      840

tataaaccgg ctccatacag cggtttcgac ctgttcaacc atatggctga cgtcgtaact      900

gcacgtgcca gagtggaagc cgctgaggca tttgagcttc tggcagacga tctggaagag      960

acagttaaga agggtgagac gacaactccg ttcccggaga aataccgtgt tatgttcgag     1020

ggtattcctt gctggccgaa gctgcctaac ctgttcaaac ctctgaaaga gcatggcgtc     1080

aacgttactg ccgttgttta tgcaccagct ttcggttttg tttataacaa catcgatgag     1140

atggcccgcg cttactacaa agctccgaac tccgtctgca tcgaacaggg tgttgactgg     1200

cgtgaaggta tctgccgcga caataaggta gatggcgttc ttgttcatta taacagaagc     1260

tgtaaaccgt ggagcggtta tatggctgag atgcagcggc gtttcactga agatctgggc     1320

gttccatgcg caggtttcga cggtgaccag gctgacccgc gtaacttcaa tgccgctcag     1380

tatgagaccc gagtacaggg ccttgtggag gcaatggaag caaataagca ggcaaaggag     1440

gcaaaggtcg ac                                                         1452


<210>  163
<211>  1452
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized hgdA, (R)-2-hydroxyglutaryl-CoA dehydratase 
       subunit A polynucleotide

<400>  163
ggatccatgg ctaaacaggt ctctccagga gtcttagcat taaggaaggt cgtcgatgac       60

gtccacaaag aggctaggga agcaaaggct aggggtgagt tggtcggttg gtcatcttca      120

aagttcccat gcgagttggc agcagctttc gacttgaacg tcatgtaccc agagaaccag      180

gcagctggta tagcagcaaa caggtacggt gagatgatgt gtcaggcagc tgaggacttg      240

ggatacgaca acgacatttg cggttacgct aggatttctt tggcatacgc agcaggtgtc      300

agggtctcaa gaaagtacga cgcagagaca ggagagtaca ttattgaccc agcaacagga      360

aagcctttga aggacgctga gggtaacgtc gtcattgatg aggcaactgg aaagccaaag      420

aaggacccaa agactcagac tccatacttg gtcttagata atttgttgga gatagaggct      480

ttgcctgacg gtccagagaa ggagaggagg ttggaagcaa tttctcctat aagacaaatg      540

aggattcctc aacctgactt tgtcttgtgt tgtaacaaca tatgtaattg catgacaaaa      600

tggtacgaga acattgctag gatgtgtaac gttcctttaa ttatgataga cataccttac      660

aacaatactg ttgaggtcca tgacgacaac gtcaagtacg tcagggcaca gtttgacaag      720

gcaataaaac aattggagga gttgactgga aagaaattcg acgagaagaa gtttgaaaag      780

gcttgctcta acgctaacag aactgctcag gcatggttga aggtctgcga ctacttgcag      840

tataagcctg ctccatactc tggatttgat ttattcaacc acatggctga cgtcgtcact      900

gctagggcta gagttgaggc tgcagaggca ttcgagttgt tggcagacga cttggaggag      960

acagttaaga agggagaaac tactactcct ttccctgaga agtacagggt catgttcgag     1020

ggaattcctt gctggccaaa gttgcctaac ttatttaaac cattgaagga gcacggagtc     1080

aacgttacag ctgtcgtcta cgctccagct ttcggttttg tttacaataa tattgacgag     1140

atggcaagag cttattacaa agctccaaac tctgtctgta tagaacaggg agttgactgg     1200

agagagggta tatgcagaga caacaaggtt gacggagtct tagtccacta caacaggtct     1260

tgcaagccat ggtctggata catggcagag atgcagagga ggtttacaga agacttggga     1320

gtcccttgcg ctggtttcga tggagaccaa gctgacccaa ggaacttcaa cgctgctcag     1380

tacgagacaa gggtccaagg attagtcgag gctatggagg ctaacaagca ggcaaaggaa     1440

gctaaggtcg ac                                                         1452


<210>  164
<211>  482
<212>  PRT
<213>  Clostridium symbiosum

<400>  164

Met Ala Lys Gln Val Ser Pro Gly Val Leu Ala Leu Arg Lys Val Val 
1               5                   10                  15      


Asp Asp Val His Lys Glu Ala Arg Glu Ala Lys Ala Arg Gly Glu Leu 
            20                  25                  30          


Val Gly Trp Ser Ser Ser Lys Phe Pro Cys Glu Leu Ala Ala Ala Phe 
        35                  40                  45              


Asp Leu Asn Val Met Tyr Pro Glu Asn Gln Ala Ala Gly Ile Ala Ala 
    50                  55                  60                  


Asn Arg Tyr Gly Glu Met Met Cys Gln Ala Ala Glu Asp Leu Gly Tyr 
65                  70                  75                  80  


Asp Asn Asp Ile Cys Gly Tyr Ala Arg Ile Ser Leu Ala Tyr Ala Ala 
                85                  90                  95      


Gly Val Arg Val Ser Arg Lys Tyr Asp Ala Glu Thr Gly Glu Tyr Ile 
            100                 105                 110         


Ile Asp Pro Ala Thr Gly Lys Pro Leu Lys Asp Ala Glu Gly Asn Val 
        115                 120                 125             


Val Ile Asp Glu Ala Thr Gly Lys Pro Lys Lys Asp Pro Lys Thr Gln 
    130                 135                 140                 


Thr Pro Tyr Leu Val Leu Asp Asn Leu Leu Glu Ile Glu Ala Leu Pro 
145                 150                 155                 160 


Asp Gly Pro Glu Lys Glu Arg Arg Leu Glu Ala Ile Ser Pro Ile Arg 
                165                 170                 175     


Gln Met Arg Ile Pro Gln Pro Asp Phe Val Leu Cys Cys Asn Asn Ile 
            180                 185                 190         


Cys Asn Cys Met Thr Lys Trp Tyr Glu Asn Ile Ala Arg Met Cys Asn 
        195                 200                 205             


Val Pro Leu Ile Met Ile Asp Ile Pro Tyr Asn Asn Thr Val Glu Val 
    210                 215                 220                 


His Asp Asp Asn Val Lys Tyr Val Arg Ala Gln Phe Asp Lys Ala Ile 
225                 230                 235                 240 


Lys Gln Leu Glu Glu Leu Thr Gly Lys Lys Phe Asp Glu Lys Lys Phe 
                245                 250                 255     


Glu Lys Ala Cys Ser Asn Ala Asn Arg Thr Ala Gln Ala Trp Leu Lys 
            260                 265                 270         


Val Cys Asp Tyr Leu Gln Tyr Lys Pro Ala Pro Tyr Ser Gly Phe Asp 
        275                 280                 285             


Leu Phe Asn His Met Ala Asp Val Val Thr Ala Arg Ala Arg Val Glu 
    290                 295                 300                 


Ala Ala Glu Ala Phe Glu Leu Leu Ala Asp Asp Leu Glu Glu Thr Val 
305                 310                 315                 320 


Lys Lys Gly Glu Thr Thr Thr Pro Phe Pro Glu Lys Tyr Arg Val Met 
                325                 330                 335     


Phe Glu Gly Ile Pro Cys Trp Pro Lys Leu Pro Asn Leu Phe Lys Pro 
            340                 345                 350         


Leu Lys Glu His Gly Val Asn Val Thr Ala Val Val Tyr Ala Pro Ala 
        355                 360                 365             


Phe Gly Phe Val Tyr Asn Asn Ile Asp Glu Met Ala Arg Ala Tyr Tyr 
    370                 375                 380                 


Lys Ala Pro Asn Ser Val Cys Ile Glu Gln Gly Val Asp Trp Arg Glu 
385                 390                 395                 400 


Gly Ile Cys Arg Asp Asn Lys Val Asp Gly Val Leu Val His Tyr Asn 
                405                 410                 415     


Arg Ser Cys Lys Pro Trp Ser Gly Tyr Met Ala Glu Met Gln Arg Arg 
            420                 425                 430         


Phe Thr Glu Asp Leu Gly Val Pro Cys Ala Gly Phe Asp Gly Asp Gln 
        435                 440                 445             


Ala Asp Pro Arg Asn Phe Asn Ala Ala Gln Tyr Glu Thr Arg Val Gln 
    450                 455                 460                 


Gly Leu Val Glu Ala Met Glu Ala Asn Lys Gln Ala Lys Glu Ala Lys 
465                 470                 475                 480 


Val Asp 
        


<210>  165
<211>  1161
<212>  DNA
<213>  Clostridium symbiosum

<400>  165
ggatccatga gtatcaacgc attattggat gaatttaaag taaaggctgc cactccaaaa       60

cagcagcttg ctgaatataa agctcagggc aagaaagtaa tcggtgttct gccgtattac      120

gcaccggaag agcttgttta tgccgcaggt atggtgccga tgggaatctg gggttccaat      180

aacaagacta tcagccgtgc taaagaatac tgtgcaactt tctactgcac tatcgcacag      240

cttgctctgg agatgctgtt agacggcaca atggatcagc tggacggaat cattactcca      300

accatctgtg atacactgcg cccaatgagc cagaacttcc gtgttgctat gggagataag      360

atggcagtta tcttccttgc tcagcctcag aaccgttttg aagatttcgg tcttcagttc      420

agtgttgacc agtatacaaa tgttaagaaa gaactggaaa aagttgccgg taaagagatt      480

accaacgagg cgattcagga tgccatcaaa gtatacaata agagccgtgc ggcccgccgt      540

aaattcgtag aactggcaag cgcacactgc gatgtcatta caccaaccaa gcgttctgca      600

gtactgaaat ccttcttctt tatggagaaa ccggaataca tagagaagct ggaagaattg      660

aacgcagagc ttgaaaaact tcctgtctgt gactggcagg gaaccaaggt tgttacatcc      720

ggtattatct gtgacaatcc aaagcttctt gaaatcttcg aagagaacaa cattgccatc      780

gccgcagacg acgttggcca tgagagccgt tccttccgtg tagacgctcc ggaggatgag      840

gcagatgcat taatggcact ggcaaaacag tttgccaata tggactatga cgttcttctg      900

tacgatccaa aatctacaga gaaccgccgc ggcgaattca ttgccaacat ggtaaaggaa      960

agcggcgctc agggactggt attgttcatg caacagttct gtgacccgga ggaaatggag     1020

tatccatact taaagaaggc attaaataat gcaggtattc cgcatatcaa actgggtatc     1080

gatcagcaga tgcgtgactt cggtcaggca agcacagcta tccaggcatt tgcagatgta     1140

ctcgagatgc agaaagtcga c                                               1161


<210>  166
<211>  1161
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized hgdB, (R)-2-hydroxyglutaryl-CoA dehydratase 
       subunit B polynucleotide

<400>  166
ggatccatgt ctattaatgc attgttagac gagttcaagg tcaaggcagc tactccaaag       60

cagcagttgg cagagtataa ggctcagggt aagaaggtca taggagtctt gccttactac      120

gcacctgagg aattggtcta cgctgctggt atggtcccaa tgggtatatg gggttctaat      180

aataagacta tttctagagc taaggaatat tgtgctacat tctactgtac aattgctcag      240

ttggcattag aaatgttgtt ggatggtaca atggaccagt tggacggaat aataacacca      300

acaatttgtg acactttgag gccaatgtct cagaacttca gggtcgcaat gggtgataaa      360

atggctgtca tatttttagc tcagccacag aacaggttcg aggacttcgg tttgcagttc      420

tcagttgacc agtatacaaa cgtcaagaag gaattggaga aggtcgctgg taaggagata      480

actaacgagg ctatacagga cgctataaag gtttacaaca agtcaagggc tgcaaggaga      540

aagttcgtcg agttggcatc agctcactgc gacgtcatta ctccaacaaa gagatctgct      600

gtcttaaagt ctttcttttt catggaaaag cctgagtaca ttgaaaagtt ggaagagttg      660

aacgcagagt tggaaaagtt gcctgtctgc gattggcagg gtactaaggt tgtcacatct      720

ggtataatat gcgacaatcc aaagttattg gaaattttcg aggaaaacaa cattgctata      780

gctgctgacg acgtcggtca cgagtctagg tcatttaggg ttgacgctcc tgaagacgag      840

gcagacgctt tgatggcatt ggctaagcag ttcgctaata tggattacga tgtcttattg      900

tacgacccta aatctactga aaataggaga ggagaattca ttgctaacat ggtcaaggag      960

tctggtgctc agggtttggt cttgttcatg caacagttct gcgacccaga ggagatggaa     1020

tacccttact taaagaaggc attgaataac gctggaatac cacacataaa attaggaatt     1080

gaccagcaga tgagggactt cggtcaggct tcaactgcaa tacaggcttt cgctgacgtc     1140

ttggagatgc agaaagtcga c                                               1161


<210>  167
<211>  385
<212>  PRT
<213>  Clostridium symbiosum

<400>  167

Met Ser Ile Asn Ala Leu Leu Asp Glu Phe Lys Val Lys Ala Ala Thr 
1               5                   10                  15      


Pro Lys Gln Gln Leu Ala Glu Tyr Lys Ala Gln Gly Lys Lys Val Ile 
            20                  25                  30          


Gly Val Leu Pro Tyr Tyr Ala Pro Glu Glu Leu Val Tyr Ala Ala Gly 
        35                  40                  45              


Met Val Pro Met Gly Ile Trp Gly Ser Asn Asn Lys Thr Ile Ser Arg 
    50                  55                  60                  


Ala Lys Glu Tyr Cys Ala Thr Phe Tyr Cys Thr Ile Ala Gln Leu Ala 
65                  70                  75                  80  


Leu Glu Met Leu Leu Asp Gly Thr Met Asp Gln Leu Asp Gly Ile Ile 
                85                  90                  95      


Thr Pro Thr Ile Cys Asp Thr Leu Arg Pro Met Ser Gln Asn Phe Arg 
            100                 105                 110         


Val Ala Met Gly Asp Lys Met Ala Val Ile Phe Leu Ala Gln Pro Gln 
        115                 120                 125             


Asn Arg Phe Glu Asp Phe Gly Leu Gln Phe Ser Val Asp Gln Tyr Thr 
    130                 135                 140                 


Asn Val Lys Lys Glu Leu Glu Lys Val Ala Gly Lys Glu Ile Thr Asn 
145                 150                 155                 160 


Glu Ala Ile Gln Asp Ala Ile Lys Val Tyr Asn Lys Ser Arg Ala Ala 
                165                 170                 175     


Arg Arg Lys Phe Val Glu Leu Ala Ser Ala His Cys Asp Val Ile Thr 
            180                 185                 190         


Pro Thr Lys Arg Ser Ala Val Leu Lys Ser Phe Phe Phe Met Glu Lys 
        195                 200                 205             


Pro Glu Tyr Ile Glu Lys Leu Glu Glu Leu Asn Ala Glu Leu Glu Lys 
    210                 215                 220                 


Leu Pro Val Cys Asp Trp Gln Gly Thr Lys Val Val Thr Ser Gly Ile 
225                 230                 235                 240 


Ile Cys Asp Asn Pro Lys Leu Leu Glu Ile Phe Glu Glu Asn Asn Ile 
                245                 250                 255     


Ala Ile Ala Ala Asp Asp Val Gly His Glu Ser Arg Ser Phe Arg Val 
            260                 265                 270         


Asp Ala Pro Glu Asp Glu Ala Asp Ala Leu Met Ala Leu Ala Lys Gln 
        275                 280                 285             


Phe Ala Asn Met Asp Tyr Asp Val Leu Leu Tyr Asp Pro Lys Ser Thr 
    290                 295                 300                 


Glu Asn Arg Arg Gly Glu Phe Ile Ala Asn Met Val Lys Glu Ser Gly 
305                 310                 315                 320 


Ala Gln Gly Leu Val Leu Phe Met Gln Gln Phe Cys Asp Pro Glu Glu 
                325                 330                 335     


Met Glu Tyr Pro Tyr Leu Lys Lys Ala Leu Asn Asn Ala Gly Ile Pro 
            340                 345                 350         


His Ile Lys Leu Gly Ile Asp Gln Gln Met Arg Asp Phe Gly Gln Ala 
        355                 360                 365             


Ser Thr Ala Ile Gln Ala Phe Ala Asp Val Leu Glu Met Gln Lys Val 
    370                 375                 380                 


Asp 
385 


<210>  168
<211>  794
<212>  DNA
<213>  Acidaminococcus fermentans

<400>  168
gaattcatga gtatctatac cttgggaatc gatgttggat ctactgcatc caagtgcatt       60

atcctgaaag atggaaaaga aatcgtggcg aaatccctgg tagccgtggg gaccggaact      120

tccggtcccg cacggtctat ttcggaagtc ctggaaaatg cccacatgaa aaaagaagac      180

atggccttta ccctggctac cggctacgga cgcaattcgc tggaaggcat tgccgacaag      240

cagatgagcg aactgagctg ccatgccatg ggcgccagct ttatctggcc caacgtccat      300

accgtcatcg atatcggcgg gcaggatgtg aaggtcatcc atgtggaaaa cgggaccatg      360

accaatttcc agatgaatga taaatgcgct gccgggactg gccgtttcct ggatgttatg      420

gccaatatcc tggaagtgaa ggtttccgac ctggctgagc tgggagccaa atccaccaaa      480

cgggtggcta tcagctccac ctgtactgtg tttgcagaaa gtgaagtcat cagccagctg      540

tccaaaggaa ccgacaagat cgacatcatt gccgggatcc atcgttctgt agccagccgg      600

gtcattggtc ttgccaatcg ggtggggatt gtgaaagacg tggtcatgac cggcggtgta      660

gcccagaact atggcgtgag aggagccctg gaagaaggcc ttggcgtgga aatcaagacg      720

tctcccctgg ctcagtacaa cggtgccctg ggtgccgctc tgtatgcgta taaaaaagca      780

gccaaagcac tagt                                                        794


<210>  169
<211>  794
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized hgdC (R)-2-hydroxyglutaryl-CoA dehydratase 
       subunit C polynucleotide

<400>  169
gaattcatgt ctatatacac attgggtata gacgtcggtt ctactgcttc aaagtgcatt       60

attttgaagg acggaaagga gatagtcgca aagtcattgg tcgctgtcgg tactggtaca      120

tctggtccag ctaggtctat atcagaggtc ttggaaaacg cacacatgaa gaaggaggac      180

atggctttca ctttagctac aggttacggt aggaactctt tggaaggaat agctgacaag      240

cagatgtctg agttgtcttg ccacgcaatg ggtgcttctt tcatatggcc aaacgtccac      300

actgtcatag acataggagg tcaggacgtc aaggtcattc acgtcgagaa cggaactatg      360

actaacttcc agatgaacga taagtgcgct gctggtacag gtagattctt ggacgttatg      420

gctaacatat tagaagtcaa ggtctctgac ttggctgagt tgggtgctaa gtcaactaag      480

agggtcgcaa tttcatcaac atgcactgtc ttcgctgagt ctgaggtcat atcacagtta      540

tcaaagggta cagacaagat agacataata gcaggtattc acaggtctgt cgcatctagg      600

gtcattggtt tggcaaatag ggtcggtatt gtcaaggacg tcgtcatgac aggaggagtc      660

gctcagaact acggtgtcag gggtgcattg gaggagggtt tgggtgtcga gataaagact      720

tctcctttgg ctcagtacaa cggagctttg ggtgcagcat tgtacgctta caagaaagct      780

gcaaaggcac tagt                                                        794


<210>  170
<211>  262
<212>  PRT
<213>  Acidaminococcus fermentans

<400>  170

Met Ser Ile Tyr Thr Leu Gly Ile Asp Val Gly Ser Thr Ala Ser Lys 
1               5                   10                  15      


Cys Ile Ile Leu Lys Asp Gly Lys Glu Ile Val Ala Lys Ser Leu Val 
            20                  25                  30          


Ala Val Gly Thr Gly Thr Ser Gly Pro Ala Arg Ser Ile Ser Glu Val 
        35                  40                  45              


Leu Glu Asn Ala His Met Lys Lys Glu Asp Met Ala Phe Thr Leu Ala 
    50                  55                  60                  


Thr Gly Tyr Gly Arg Asn Ser Leu Glu Gly Ile Ala Asp Lys Gln Met 
65                  70                  75                  80  


Ser Glu Leu Ser Cys His Ala Met Gly Ala Ser Phe Ile Trp Pro Asn 
                85                  90                  95      


Val His Thr Val Ile Asp Ile Gly Gly Gln Asp Val Lys Val Ile His 
            100                 105                 110         


Val Glu Asn Gly Thr Met Thr Asn Phe Gln Met Asn Asp Lys Cys Ala 
        115                 120                 125             


Ala Gly Thr Gly Arg Phe Leu Asp Val Met Ala Asn Ile Leu Glu Val 
    130                 135                 140                 


Lys Val Ser Asp Leu Ala Glu Leu Gly Ala Lys Ser Thr Lys Arg Val 
145                 150                 155                 160 


Ala Ile Ser Ser Thr Cys Thr Val Phe Ala Glu Ser Glu Val Ile Ser 
                165                 170                 175     


Gln Leu Ser Lys Gly Thr Asp Lys Ile Asp Ile Ile Ala Gly Ile His 
            180                 185                 190         


Arg Ser Val Ala Ser Arg Val Ile Gly Leu Ala Asn Arg Val Gly Ile 
        195                 200                 205             


Val Lys Asp Val Val Met Thr Gly Gly Val Ala Gln Asn Tyr Gly Val 
    210                 215                 220                 


Arg Gly Ala Leu Glu Glu Gly Leu Gly Val Glu Ile Lys Thr Ser Pro 
225                 230                 235                 240 


Leu Ala Gln Tyr Asn Gly Ala Leu Gly Ala Ala Leu Tyr Ala Tyr Lys 
                245                 250                 255     


Lys Ala Ala Lys Ala Leu 
            260         


<210>  171
<211>  1170
<212>  DNA
<213>  Desulfococcus multivorans

<400>  171
atggatttca acttatccaa agaactacag atgctgcaga aagaggtccg caacttcgtc       60

aacaagaaga tcgtcccctt cgccgaccag tgggacaacg agaatcactt cccatacgag      120

gaggccgtcc ggcccatggg cgagctgggc ttcttcggga cggtgattcc cgaggagtac      180

ggcggcgaag gcatggacca gggatggctc gcggccatga tcgtcaccga ggagatcgca      240

aggggctcct ccgcactccg tgtccagctc aacatggagg tgctggggtg cgcctatacc      300

atcctgacct acgggagcga ggccctcaaa aagaaatacg tccccaagct ctccagcgcc      360

gaattcctgg gcggcttcgg catcaccgag cccgacgccg gctccgacgt catggccatg      420

tcctccacgg ccgaggacaa gggggaccac tggctcctca acggctccaa gacctggatc      480

tccaacgcgg cccaggccga cgtgctgatc tactatgcct acaccgacaa ggcggcgggc      540

tcccgggggc tttcggcctt cgtcatcgaa cccagaaact tccccggcat caagacctcc      600

aacctggaga agctgggatc ccacgcctcc cccaccggcg agctcttcct cgacaacgtc      660

aaggtgccca aggagaacat cctcggcaag cccggcgacg gcgccaggat cgtcttcgga      720

tccctcaacc acacccggct ttcagccgcc gccggcggcg ttgggctcgc ccaggcctgc      780

ctggacgccg ccatcaagta ctgcaacgag cgccgccagt tcggcaagcc catcggcgat      840

ttccagatga accaggacat gatcgcccag atggccgtcg aggtggaggc ggcccgtctt      900

ctggcctaca aggctgccgc ggcaaaggac gagggccggc tcaacaacgg cctcgacgtg      960

gccatggcca agtatgccgc cggcgaagcc gtgagcaagt gcgccaatta cgccatgcgc     1020

atcctcgggg cctacggcta ctccaccgag taccccgtcg cccgcttcta ccgcgacgca     1080

cccacctatt acatggtgga gggctcggcc aacatctgca agatgatcat cgccctggat     1140

cagctggggg tcagaaaggc caaccggtaa                                      1170


<210>  172
<211>  1170
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized gdh, glutaryl-CoA dehydrogenase polynucleotide

<400>  172
atggatttca atttgtctaa agaattgcaa atgttgcaaa aagaagttag aaatttcgtt       60

aataaaaaaa ttgttccatt cgctgatcaa tgggataatg aaaatcattt cccatatgaa      120

gaagctgtta gaccaatggg tgaattgggt ttcttcggta ctgttattcc agaagaatat      180

ggtggtgaag gtatggatca aggttggttg gctgctatga ttgttactga agaaattgct      240

agaggttctt ctgctttgag agttcaattg aatatggaag ttttgggttg tgcttatact      300

attttgactt atggttctga agctttgaaa aaaaaatatg ttccaaaatt gtcttctgct      360

gaattcttgg gtggtttcgg tattactgaa ccagatgctg gttctgatgt tatggctatg      420

tcttctactg ctgaagataa aggtgatcat tggttgttga atggttctaa aacttggatt      480

tctaatgctg ctcaagctga tgttttgatt tattatgctt atactgataa agctgctggt      540

tctagaggtt tgtctgcttt cgttattgaa ccaagaaatt tcccaggtat taaaacttct      600

aatttggaaa aattgggttc tcatgcttct ccaactggtg aattgttctt ggataatgtt      660

aaagttccaa aagaaaatat tttgggtaaa ccaggtgatg gtgctagaat tgttttcggt      720

tctttgaatc atactagatt gtctgctgct gctggtggtg ttggtttggc tcaagcttgt      780

ttggatgctg ctattaaata ttgtaatgaa agaagacaat tcggtaaacc aattggtgat      840

ttccaaatga atcaagatat gattgctcaa atggctgttg aagttgaagc tgctagattg      900

ttggcttata aagctgctgc tgctaaagat gaaggtagat tgaataatgg tttggatgtt      960

gctatggcta aatatgctgc tggtgaagct gtttctaaat gtgctaatta tgctatgaga     1020

attttgggtg cttatggtta ttctactgaa tatccagttg ctagattcta tagagatgct     1080

ccaacttatt atatggttga aggttctgct aatatttgta aaatgattat tgctttggat     1140

caattgggtg ttagaaaagc taatagataa                                      1170


<210>  173
<211>  389
<212>  PRT
<213>  Desulfococcus multivorans

<400>  173

Met Asp Phe Asn Leu Ser Lys Glu Leu Gln Met Leu Gln Lys Glu Val 
1               5                   10                  15      


Arg Asn Phe Val Asn Lys Lys Ile Val Pro Phe Ala Asp Gln Trp Asp 
            20                  25                  30          


Asn Glu Asn His Phe Pro Tyr Glu Glu Ala Val Arg Pro Met Gly Glu 
        35                  40                  45              


Leu Gly Phe Phe Gly Thr Val Ile Pro Glu Glu Tyr Gly Gly Glu Gly 
    50                  55                  60                  


Met Asp Gln Gly Trp Leu Ala Ala Met Ile Val Thr Glu Glu Ile Ala 
65                  70                  75                  80  


Arg Gly Ser Ser Ala Leu Arg Val Gln Leu Asn Met Glu Val Leu Gly 
                85                  90                  95      


Cys Ala Tyr Thr Ile Leu Thr Tyr Gly Ser Glu Ala Leu Lys Lys Lys 
            100                 105                 110         


Tyr Val Pro Lys Leu Ser Ser Ala Glu Phe Leu Gly Gly Phe Gly Ile 
        115                 120                 125             


Thr Glu Pro Asp Ala Gly Ser Asp Val Met Ala Met Ser Ser Thr Ala 
    130                 135                 140                 


Glu Asp Lys Gly Asp His Trp Leu Leu Asn Gly Ser Lys Thr Trp Ile 
145                 150                 155                 160 


Ser Asn Ala Ala Gln Ala Asp Val Leu Ile Tyr Tyr Ala Tyr Thr Asp 
                165                 170                 175     


Lys Ala Ala Gly Ser Arg Gly Leu Ser Ala Phe Val Ile Glu Pro Arg 
            180                 185                 190         


Asn Phe Pro Gly Ile Lys Thr Ser Asn Leu Glu Lys Leu Gly Ser His 
        195                 200                 205             


Ala Ser Pro Thr Gly Glu Leu Phe Leu Asp Asn Val Lys Val Pro Lys 
    210                 215                 220                 


Glu Asn Ile Leu Gly Lys Pro Gly Asp Gly Ala Arg Ile Val Phe Gly 
225                 230                 235                 240 


Ser Leu Asn His Thr Arg Leu Ser Ala Ala Ala Gly Gly Val Gly Leu 
                245                 250                 255     


Ala Gln Ala Cys Leu Asp Ala Ala Ile Lys Tyr Cys Asn Glu Arg Arg 
            260                 265                 270         


Gln Phe Gly Lys Pro Ile Gly Asp Phe Gln Met Asn Gln Asp Met Ile 
        275                 280                 285             


Ala Gln Met Ala Val Glu Val Glu Ala Ala Arg Leu Leu Ala Tyr Lys 
    290                 295                 300                 


Ala Ala Ala Ala Lys Asp Glu Gly Arg Leu Asn Asn Gly Leu Asp Val 
305                 310                 315                 320 


Ala Met Ala Lys Tyr Ala Ala Gly Glu Ala Val Ser Lys Cys Ala Asn 
                325                 330                 335     


Tyr Ala Met Arg Ile Leu Gly Ala Tyr Gly Tyr Ser Thr Glu Tyr Pro 
            340                 345                 350         


Val Ala Arg Phe Tyr Arg Asp Ala Pro Thr Tyr Tyr Met Val Glu Gly 
        355                 360                 365             


Ser Ala Asn Ile Cys Lys Met Ile Ile Ala Leu Asp Gln Leu Gly Val 
    370                 375                 380                 


Arg Lys Ala Asn Arg 
385                 


