                         SEQUENCE LISTING

<110>  Fox Chase Cancer Center
 
<120>  Estrogen Metabolite Levels and CYP1B1 Polymorphisms in Lung 
       Cancer Diagnosis, Prognosis, and Risk Assessment

<130>  185300-3066

<150>  61/603,611
<151>  2012-02-27

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Completely synthesized

<400>  1
gctgtctccc tctggtta                                                     18


<210>  2
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Completely synthesized

<400>  2
cgttgcagca ggatagcc                                                     18


<210>  3
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Completely synthesized.

<400>  3
gcggaagtgt atcggtga                                                     18


<210>  4
<211>  1630
<212>  DNA
<213>  Homo sapiens

<400>  4
atgggcacca gcctcagccc gaacgaccct tggccgctaa acccgctgtc catccagcag       60

accacgctcc tgctactcct gtcggtgctg gccactgtgc atgtgggcca gcggctgctg      120

aggcaacgga ggcggcagct ccggtccgcg cccccgggcc cgtttgcgtg gccactgatc      180

ggaaacgcgg cggcggtggg ccaggcggct cacctctcgt tcgctcgcct ggcgcggcgc      240

tacggcgacg ttttccagat ccgcctgggc agctgcccca tagtggtgct gaatggcgag      300

cgcgccatcc accaggccct ggtgcagcag ggctcggcct tcgccgaccg gccggccttc      360

gcctccttcc gtgtggtgtc cggcggccgc agcatggctt tcggccacta ctcggagcac      420

tggaaggtgc agcggcgcgc agcccacagc atgatgcgca acttcttcac gcgccagccg      480

cgcagccgcc aagtcctcga gggccacgtg ctgagcgagg cgcgcgagct ggtggcgctg      540

ctggtgcgcg gcagcgcgga cggcgccttc ctcgacccga ggccgctgac cgtcgtggcc      600

gtggccaacg tcatgagtgc cgtgtgtttc ggctgccgct acagccacga cgaccccgag      660

ttccgtgagc tgctcagcca caacgaagag ttcgggcgca cggtgggcgc gggcagcctg      720

gtggacgtga tgccctggct gcagtacttc cccaacccgg tgcgcaccgt tttccgcgaa      780

ttcgagcagc tcaaccgcaa cttcagcaac ttcatcctgg acaagttctt gaggcactgc      840

gaaagccttc ggcccggggc cgccccccgc gacatgatgg acgcctttat cctctctgcg      900

gaaaagaagg cggccgggga ctcgcacggt ggtggcgcgc ggctggattt ggagaacgta      960

ccggccacta tcactgacat cttcggcgcc agccaggaca ccctgtccac cgcgctgcag     1020

tggctgctcc tcctcttcac caggtatcct gatgtgcaga ctcgagtgca ggcagaattg     1080

gatcaggtcg tggggaggga ccgtctgcct tgtatgggtg accagcccaa cctgccctat     1140

gtcctggcct tcctttatga agccatgcgc ttctccagct ttgtgcctgt cactattcct     1200

catgccacca ctgccaacac ctctgtcttg ggctaccaca ttcccaagga cactgtggtt     1260

tttgtcaacc agtggtctgt gaatcatgac ccactgaagt ggcctaaccc ggagaacttt     1320

gatccagctc gattcttgga caaggatggc ctcatcaaca aggacctgac cagcagagtg     1380

atgatttttt cagtgggcaa aaggcggtgc attggcgaag aactttctaa gatgcagctt     1440

tttctcttca tctccatcct ggctcaccag tgcgatttca gggccaaccc aaatgagcct     1500

gcgaaaatga atttcagtta tggtctaacc attaaaccca agtcatttaa agtcaatgtc     1560

actctcagag agtccatgga gctccttgat agtgctgtcc aaaatttaca agccaaggaa     1620

acttgccaat                                                            1630


<210>  5
<211>  1630
<212>  DNA
<213>  Homo sapiens

<400>  5
atgggcacca gcctcagccc gaacgaccct tggccgctaa acccgctgtc catccagcag       60

accacgctcc tgctactcct gtcggtgctg gccactgtgc atgtgggcca gcggctgctg      120

aggcaacgga ggcggcagct cgggtccgcg cccccgggcc cgtttgcgtg gccactgatc      180

ggaaacgcgg cggcggtggg ccaggcggct cacctctcgt tcgctcgcct ggcgcggcgc      240

tacggcgacg ttttccagat ccgcctgggc agctgcccca tagtggtgct gaatggcgag      300

cgcgccatcc accaggccct ggtgcagcag ggctcggcct tcgccgaccg gccggccttc      360

gcctccttcc gtgtggtgtc cggcggccgc agcatggctt tcggccacta ctcggagcac      420

tggaaggtgc agcggcgcgc agcccacagc atgatgcgca acttcttcac gcgccagccg      480

cgcagccgcc aagtcctcga gggccacgtg ctgagcgagg cgcgcgagct ggtggcgctg      540

ctggtgcgcg gcagcgcgga cggcgccttc ctcgacccga ggccgctgac cgtcgtggcc      600

gtggccaacg tcatgagtgc cgtgtgtttc ggctgccgct acagccacga cgaccccgag      660

ttccgtgagc tgctcagcca caacgaagag ttcgggcgca cggtgggcgc gggcagcctg      720

gtggacgtga tgccctggct gcagtacttc cccaacccgg tgcgcaccgt tttccgcgaa      780

ttcgagcagc tcaaccgcaa cttcagcaac ttcatcctgg acaagttctt gaggcactgc      840

gaaagccttc ggcccggggc cgccccccgc gacatgatgg acgcctttat cctctctgcg      900

gaaaagaagg cggccgggga ctcgcacggt ggtggcgcgc ggctggattt ggagaacgta      960

ccggccacta tcactgacat cttcggcgcc agccaggaca ccctgtccac cgcgctgcag     1020

tggctgctcc tcctcttcac caggtatcct gatgtgcaga ctcgagtgca ggcagaattg     1080

gatcaggtcg tggggaggga ccgtctgcct tgtatgggtg accagcccaa cctgccctat     1140

gtcctggcct tcctttatga agccatgcgc ttctccagct ttgtgcctgt cactattcct     1200

catgccacca ctgccaacac ctctgtcttg ggctaccaca ttcccaagga cactgtggtt     1260

tttgtcaacc agtggtctgt gaatcatgac ccactgaagt ggcctaaccc ggagaacttt     1320

gatccagctc gattcttgga caaggatggc ctcatcaaca aggacctgac cagcagagtg     1380

atgatttttt cagtgggcaa aaggcggtgc attggcgaag aactttctaa gatgcagctt     1440

tttctcttca tctccatcct ggctcaccag tgcgatttca gggccaaccc aaatgagcct     1500

gcgaaaatga atttcagtta tggtctaacc attaaaccca agtcatttaa agtcaatgtc     1560

actctcagag agtccatgga gctccttgat agtgctgtcc aaaatttaca agccaaggaa     1620

acttgccaat                                                            1630


<210>  6
<211>  1630
<212>  DNA
<213>  Homo sapiens

<400>  6
atgggcacca gcctcagccc gaacgaccct tggccgctaa acccgctgtc catccagcag       60

accacgctcc tgctactcct gtcggtgctg gccactgtgc atgtgggcca gcggctgctg      120

aggcaacgga ggcggcagct cgggtccgcg cccccgggcc cgtttgcgtg gccactgatc      180

ggaaacgcgg cggcggtggg ccaggcggct cacctctcgt tcgctcgcct ggcgcggcgc      240

tacggcgacg ttttccagat ccgcctgggc agctgcccca tagtggtgct gaatggcgag      300

cgcgccatcc accaggccct ggtgcagcag ggctcggcct tcgccgaccg gccgtccttc      360

gcctccttcc gtgtggtgtc cggcggccgc agcatggctt tcggccacta ctcggagcac      420

tggaaggtgc agcggcgcgc agcccacagc atgatgcgca acttcttcac gcgccagccg      480

cgcagccgcc aagtcctcga gggccacgtg ctgagcgagg cgcgcgagct ggtggcgctg      540

ctggtgcgcg gcagcgcgga cggcgccttc ctcgacccga ggccgctgac cgtcgtggcc      600

gtggccaacg tcatgagtgc cgtgtgtttc ggctgccgct acagccacga cgaccccgag      660

ttccgtgagc tgctcagcca caacgaagag ttcgggcgca cggtgggcgc gggcagcctg      720

gtggacgtga tgccctggct gcagtacttc cccaacccgg tgcgcaccgt tttccgcgaa      780

ttcgagcagc tcaaccgcaa cttcagcaac ttcatcctgg acaagttctt gaggcactgc      840

gaaagccttc ggcccggggc cgccccccgc gacatgatgg acgcctttat cctctctgcg      900

gaaaagaagg cggccgggga ctcgcacggt ggtggcgcgc ggctggattt ggagaacgta      960

ccggccacta tcactgacat cttcggcgcc agccaggaca ccctgtccac cgcgctgcag     1020

tggctgctcc tcctcttcac caggtatcct gatgtgcaga ctcgagtgca ggcagaattg     1080

gatcaggtcg tggggaggga ccgtctgcct tgtatgggtg accagcccaa cctgccctat     1140

gtcctggcct tcctttatga agccatgcgc ttctccagct ttgtgcctgt cactattcct     1200

catgccacca ctgccaacac ctctgtcttg ggctaccaca ttcccaagga cactgtggtt     1260

tttgtcaacc agtggtctgt gaatcatgac ccactgaagt ggcctaaccc ggagaacttt     1320

gatccagctc gattcttgga caaggatggc ctcatcaaca aggacctgac cagcagagtg     1380

atgatttttt cagtgggcaa aaggcggtgc attggcgaag aactttctaa gatgcagctt     1440

tttctcttca tctccatcct ggctcaccag tgcgatttca gggccaaccc aaatgagcct     1500

gcgaaaatga atttcagtta tggtctaacc attaaaccca agtcatttaa agtcaatgtc     1560

actctcagag agtccatgga gctccttgat agtgctgtcc aaaatttaca agccaaggaa     1620

acttgccaat                                                            1630


<210>  7
<211>  1630
<212>  DNA
<213>  Homo sapiens

<400>  7
atgggcacca gcctcagccc gaacgaccct tggccgctaa acccgctgtc catccagcag       60

accacgctcc tgctactcct gtcggtgctg gccactgtgc atgtgggcca gcggctgctg      120

aggcaacgga ggcggcagct ccggtccgcg cccccgggcc cgtttgcgtg gccactgatc      180

ggaaacgcgg cggcggtggg ccaggcggct cacctctcgt tcgctcgcct ggcgcggcgc      240

tacggcgacg ttttccagat ccgcctgggc agctgcccca tagtggtgct gaatggcgag      300

cgcgccatcc accaggccct ggtgcagcag ggctcggcct tcgccgaccg gccggccttc      360

gcctccttcc gtgtggtgtc cggcggccgc agcatggctt tcggccacta ctcggagcac      420

tggaaggtgc agcggcgcgc agcccacagc atgatgcgca acttcttcac gcgccagccg      480

cgcagccgcc aagtcctcga gggccacgtg ctgagcgagg cgcgcgagct ggtggcgctg      540

ctggtgcgcg gcagcgcgga cggcgccttc ctcgacccga ggccgctgac cgtcgtggcc      600

gtggccaacg tcatgagtgc cgtgtgtttc ggctgccgct acagccacga cgaccccgag      660

ttccgtgagc tgctcagcca caacgaagag ttcgggcgca cggtgggcgc gggcagcctg      720

gtggacgtga tgccctggct gcagtacttc cccaacccgg tgcgcaccgt tttccgcgaa      780

ttcgagcagc tcaaccgcaa cttcagcaac ttcatcctgg acaagttctt gaggcactgc      840

gaaagccttc ggcccggggc cgccccccgc gacatgatgg acgcctttat cctctctgcg      900

gaaaagaagg cggccgggga ctcgcacggt ggtggcgcgc ggctggattt ggagaacgta      960

ccggccacta tcactgacat cttcggcgcc agccaggaca ccctgtccac cgcgctgcag     1020

tggctgctcc tcctcttcac caggtatcct gatgtgcaga ctcgagtgca ggcagaattg     1080

gatcaggtcg tggggaggga ccgtctgcct tgtatgggtg accagcccaa cctgccctat     1140

gtcctggcct tcctttatga agccatgcgc ttctccagct ttgtgcctgt cactattcct     1200

catgccacca ctgccaacac ctctgtcttg ggctaccaca ttcccaagga cactgtggtt     1260

tttgtcaacc agtggtctgt gaatcatgac ccagtgaagt ggcctaaccc ggagaacttt     1320

gatccagctc gattcttgga caaggatggc ctcatcaaca aggacctgac cagcagagtg     1380

atgatttttt cagtgggcaa aaggcggtgc attggcgaag aactttctaa gatgcagctt     1440

tttctcttca tctccatcct ggctcaccag tgcgatttca gggccaaccc aaatgagcct     1500

gcgaaaatga atttcagtta tggtctaacc attaaaccca agtcatttaa agtcaatgtc     1560

actctcagag agtccatgga gctccttgat agtgctgtcc aaaatttaca agccaaggaa     1620

acttgccaat                                                            1630


<210>  8
<211>  1630
<212>  DNA
<213>  Homo sapiens

<400>  8
atgggcacca gcctcagccc gaacgaccct tggccgctaa acccgctgtc catccagcag       60

accacgctcc tgctactcct gtcggtgctg gccactgtgc atgtgggcca gcggctgctg      120

aggcaacgga ggcggcagct ccggtccgcg cccccgggcc cgtttgcgtg gccactgatc      180

ggaaacgcgg cggcggtggg ccaggcggct cacctctcgt tcgctcgcct ggcgcggcgc      240

tacggcgacg ttttccagat ccgcctgggc agctgcccca tagtggtgct gaatggcgag      300

cgcgccatcc accaggccct ggtgcagcag ggctcggcct tcgccgaccg gccggccttc      360

gcctccttcc gtgtggtgtc cggcggccgc agcatggctt tcggccacta ctcggagcac      420

tggaaggtgc agcggcgcgc agcccacagc atgatgcgca acttcttcac gcgccagccg      480

cgcagccgcc aagtcctcga gggccacgtg ctgagcgagg cgcgcgagct ggtggcgctg      540

ctggtgcgcg gcagcgcgga cggcgccttc ctcgacccga ggccgctgac cgtcgtggcc      600

gtggccaacg tcatgagtgc cgtgtgtttc ggctgccgct acagccacga cgaccccgag      660

ttccgtgagc tgctcagcca caacgaagag ttcgggcgca cggtgggcgc gggcagcctg      720

gtggacgtga tgccctggct gcagtacttc cccaacccgg tgcgcaccgt tttccgcgaa      780

ttcgagcagc tcaaccgcaa cttcagcaac ttcatcctgg acaagttctt gaggcactgc      840

gaaagccttc ggcccggggc cgccccccgc gacatgatgg acgcctttat cctctctgcg      900

gaaaagaagg cggccgggga ctcgcacggt ggtggcgcgc ggctggattt ggagaacgta      960

ccggccacta tcactgacat cttcggcgcc agccaggaca ccctgtccac cgcgctgcag     1020

tggctgctcc tcctcttcac caggtatcct gatgtgcaga ctcgagtgca ggcagaattg     1080

gatcaggtcg tggggaggga ccgtctgcct tgtatgggtg accagcccaa cctgccctat     1140

gtcctggcct tcctttatga agccatgcgc ttctccagct ttgtgcctgt cactattcct     1200

catgccacca ctgccaacac ctctgtcttg ggctaccaca ttcccaagga cactgtggtt     1260

tttgtcaacc agtggtctgt gaatcatgac ccactgaagt ggcctaaccc ggagaacttt     1320

gatccagctc gattcttgga caaggatggc ctcatcagca aggacctgac cagcagagtg     1380

atgatttttt cagtgggcaa aaggcggtgc attggcgaag aactttctaa gatgcagctt     1440

tttctcttca tctccatcct ggctcaccag tgcgatttca gggccaaccc aaatgagcct     1500

gcgaaaatga atttcagtta tggtctaacc attaaaccca agtcatttaa agtcaatgtc     1560

actctcagag agtccatgga gctccttgat agtgctgtcc aaaatttaca agccaaggaa     1620

acttgccaat                                                            1630


<210>  9
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Gly Thr Ser Leu Ser Pro Asn Asp Pro Trp Pro Leu Asn Pro Leu 
1               5                   10                  15      


Ser Ile Gln Gln Thr Thr Leu Leu Leu Leu Leu Ser Val Leu Ala Thr 
            20                  25                  30          


Val His Val Gly Gln Arg Leu Leu Arg Gln Arg Arg Arg Gln Leu Arg 
        35                  40                  45              


Ser Ala Pro Pro Gly Pro Phe Ala Trp Pro Leu Ile Gly Asn Ala Ala 
    50                  55                  60                  


Ala Val Gly Gln Ala Ala His Leu Ser Phe Ala Arg Leu Ala Arg Arg 
65                  70                  75                  80  


Tyr Gly Asp Val Phe Gln Ile Arg Leu Gly Ser Cys Pro Ile Val Val 
                85                  90                  95      


Leu Asn Gly Glu Arg Ala Ile His Gln Ala Leu Val Gln Gln Gly Ser 
            100                 105                 110         


Ala Phe Ala Asp Arg Pro Ala Phe Ala Ser Phe Arg Val Val Ser Gly 
        115                 120                 125             


Gly Arg Ser Met Ala Phe Gly His Tyr Ser Glu His Trp Lys Val Gln 
    130                 135                 140                 


Arg Arg Ala Ala His Ser Met Met Arg Asn Phe Phe Thr Arg Gln Pro 
145                 150                 155                 160 


Arg Ser Arg Gln Val Leu Glu Gly His Val Leu Ser Glu Ala Arg Glu 
                165                 170                 175     


Leu Val Ala Leu Leu Val Arg Gly Ser Ala Asp Gly Ala Phe Leu Asp 
            180                 185                 190         


Pro Arg Pro Leu Thr Val Val Ala Val Ala Asn Val Met Ser Ala Val 
        195                 200                 205             


Cys Phe Gly Cys Arg Tyr Ser His Asp Asp Pro Glu Phe Arg Glu Leu 
    210                 215                 220                 


Leu Ser His Asn Glu Glu Phe Gly Arg Thr Val Gly Ala Gly Ser Leu 
225                 230                 235                 240 


Val Asp Val Met Pro Trp Leu Gln Tyr Phe Pro Asn Pro Val Arg Thr 
                245                 250                 255     


Val Phe Arg Glu Phe Glu Gln Leu Asn Arg Asn Phe Ser Asn Phe Ile 
            260                 265                 270         


Leu Asp Lys Phe Leu Arg His Cys Glu Ser Leu Arg Pro Gly Ala Ala 
        275                 280                 285             


Pro Arg Asp Met Met Asp Ala Phe Ile Leu Ser Ala Glu Lys Lys Ala 
    290                 295                 300                 


Ala Gly Asp Ser His Gly Gly Gly Ala Arg Leu Asp Leu Glu Asn Val 
305                 310                 315                 320 


Pro Ala Thr Ile Thr Asp Ile Phe Gly Ala Ser Gln Asp Thr Leu Ser 
                325                 330                 335     


Thr Ala Leu Gln Trp Leu Leu Leu Leu Phe Thr Arg Tyr Pro Asp Val 
            340                 345                 350         


Gln Thr Arg Val Gln Ala Glu Leu Asp Gln Val Val Gly Arg Asp Arg 
        355                 360                 365             


Leu Pro Cys Met Gly Asp Gln Pro Asn Leu Pro Tyr Val Leu Ala Phe 
    370                 375                 380                 


Leu Tyr Glu Ala Met Arg Phe Ser Ser Phe Val Pro Val Thr Ile Pro 
385                 390                 395                 400 


His Ala Thr Thr Ala Asn Thr Ser Val Leu Gly Tyr His Ile Pro Lys 
                405                 410                 415     


Asp Thr Val Val Phe Val Asn Gln Trp Ser Val Asn His Asp Pro Leu 
            420                 425                 430         


Lys Trp Pro Asn Pro Glu Asn Phe Asp Pro Ala Arg Phe Leu Asp Lys 
        435                 440                 445             


Asp Gly Leu Ile Asn Lys Asp Leu Thr Ser Arg Val Met Ile Phe Ser 
    450                 455                 460                 


Val Gly Lys Arg Arg Cys Ile Gly Glu Glu Leu Ser Lys Met Gln Leu 
465                 470                 475                 480 


Phe Leu Phe Ile Ser Ile Leu Ala His Gln Cys Asp Phe Arg Ala Asn 
                485                 490                 495     


Pro Asn Glu Pro Ala Lys Met Asn Phe Ser Tyr Gly Leu Thr Ile Lys 
            500                 505                 510         


Pro Lys Ser Phe Lys Val Asn Val Thr Leu Arg Glu Ser Met Glu Leu 
        515                 520                 525             


Leu Asp Ser Ala Val Gln Asn Leu Gln Ala Lys Glu Thr Cys Gln 
    530                 535                 540             


<210>  10
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Gly Thr Ser Leu Ser Pro Asn Asp Pro Trp Pro Leu Asn Pro Leu 
1               5                   10                  15      


Ser Ile Gln Gln Thr Thr Leu Leu Leu Leu Leu Ser Val Leu Ala Thr 
            20                  25                  30          


Val His Val Gly Gln Arg Leu Leu Arg Gln Arg Arg Arg Gln Leu Gly 
        35                  40                  45              


Ser Ala Pro Pro Gly Pro Phe Ala Trp Pro Leu Ile Gly Asn Ala Ala 
    50                  55                  60                  


Ala Val Gly Gln Ala Ala His Leu Ser Phe Ala Arg Leu Ala Arg Arg 
65                  70                  75                  80  


Tyr Gly Asp Val Phe Gln Ile Arg Leu Gly Ser Cys Pro Ile Val Val 
                85                  90                  95      


Leu Asn Gly Glu Arg Ala Ile His Gln Ala Leu Val Gln Gln Gly Ser 
            100                 105                 110         


Ala Phe Ala Asp Arg Pro Ala Phe Ala Ser Phe Arg Val Val Ser Gly 
        115                 120                 125             


Gly Arg Ser Met Ala Phe Gly His Tyr Ser Glu His Trp Lys Val Gln 
    130                 135                 140                 


Arg Arg Ala Ala His Ser Met Met Arg Asn Phe Phe Thr Arg Gln Pro 
145                 150                 155                 160 


Arg Ser Arg Gln Val Leu Glu Gly His Val Leu Ser Glu Ala Arg Glu 
                165                 170                 175     


Leu Val Ala Leu Leu Val Arg Gly Ser Ala Asp Gly Ala Phe Leu Asp 
            180                 185                 190         


Pro Arg Pro Leu Thr Val Val Ala Val Ala Asn Val Met Ser Ala Val 
        195                 200                 205             


Cys Phe Gly Cys Arg Tyr Ser His Asp Asp Pro Glu Phe Arg Glu Leu 
    210                 215                 220                 


Leu Ser His Asn Glu Glu Phe Gly Arg Thr Val Gly Ala Gly Ser Leu 
225                 230                 235                 240 


Val Asp Val Met Pro Trp Leu Gln Tyr Phe Pro Asn Pro Val Arg Thr 
                245                 250                 255     


Val Phe Arg Glu Phe Glu Gln Leu Asn Arg Asn Phe Ser Asn Phe Ile 
            260                 265                 270         


Leu Asp Lys Phe Leu Arg His Cys Glu Ser Leu Arg Pro Gly Ala Ala 
        275                 280                 285             


Pro Arg Asp Met Met Asp Ala Phe Ile Leu Ser Ala Glu Lys Lys Ala 
    290                 295                 300                 


Ala Gly Asp Ser His Gly Gly Gly Ala Arg Leu Asp Leu Glu Asn Val 
305                 310                 315                 320 


Pro Ala Thr Ile Thr Asp Ile Phe Gly Ala Ser Gln Asp Thr Leu Ser 
                325                 330                 335     


Thr Ala Leu Gln Trp Leu Leu Leu Leu Phe Thr Arg Tyr Pro Asp Val 
            340                 345                 350         


Gln Thr Arg Val Gln Ala Glu Leu Asp Gln Val Val Gly Arg Asp Arg 
        355                 360                 365             


Leu Pro Cys Met Gly Asp Gln Pro Asn Leu Pro Tyr Val Leu Ala Phe 
    370                 375                 380                 


Leu Tyr Glu Ala Met Arg Phe Ser Ser Phe Val Pro Val Thr Ile Pro 
385                 390                 395                 400 


His Ala Thr Thr Ala Asn Thr Ser Val Leu Gly Tyr His Ile Pro Lys 
                405                 410                 415     


Asp Thr Val Val Phe Val Asn Gln Trp Ser Val Asn His Asp Pro Leu 
            420                 425                 430         


Lys Trp Pro Asn Pro Glu Asn Phe Asp Pro Ala Arg Phe Leu Asp Lys 
        435                 440                 445             


Asp Gly Leu Ile Asn Lys Asp Leu Thr Ser Arg Val Met Ile Phe Ser 
    450                 455                 460                 


Val Gly Lys Arg Arg Cys Ile Gly Glu Glu Leu Ser Lys Met Gln Leu 
465                 470                 475                 480 


Phe Leu Phe Ile Ser Ile Leu Ala His Gln Cys Asp Phe Arg Ala Asn 
                485                 490                 495     


Pro Asn Glu Pro Ala Lys Met Asn Phe Ser Tyr Gly Leu Thr Ile Lys 
            500                 505                 510         


Pro Lys Ser Phe Lys Val Asn Val Thr Leu Arg Glu Ser Met Glu Leu 
        515                 520                 525             


Leu Asp Ser Ala Val Gln Asn Leu Gln Ala Lys Glu Thr Cys Gln 
    530                 535                 540             


<210>  11
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Gly Thr Ser Leu Ser Pro Asn Asp Pro Trp Pro Leu Asn Pro Leu 
1               5                   10                  15      


Ser Ile Gln Gln Thr Thr Leu Leu Leu Leu Leu Ser Val Leu Ala Thr 
            20                  25                  30          


Val His Val Gly Gln Arg Leu Leu Arg Gln Arg Arg Arg Gln Leu Gly 
        35                  40                  45              


Ser Ala Pro Pro Gly Pro Phe Ala Trp Pro Leu Ile Gly Asn Ala Ala 
    50                  55                  60                  


Ala Val Gly Gln Ala Ala His Leu Ser Phe Ala Arg Leu Ala Arg Arg 
65                  70                  75                  80  


Tyr Gly Asp Val Phe Gln Ile Arg Leu Gly Ser Cys Pro Ile Val Val 
                85                  90                  95      


Leu Asn Gly Glu Arg Ala Ile His Gln Ala Leu Val Gln Gln Gly Ser 
            100                 105                 110         


Ala Phe Ala Asp Arg Pro Ser Phe Ala Ser Phe Arg Val Val Ser Gly 
        115                 120                 125             


Gly Arg Ser Met Ala Phe Gly His Tyr Ser Glu His Trp Lys Val Gln 
    130                 135                 140                 


Arg Arg Ala Ala His Ser Met Met Arg Asn Phe Phe Thr Arg Gln Pro 
145                 150                 155                 160 


Arg Ser Arg Gln Val Leu Glu Gly His Val Leu Ser Glu Ala Arg Glu 
                165                 170                 175     


Leu Val Ala Leu Leu Val Arg Gly Ser Ala Asp Gly Ala Phe Leu Asp 
            180                 185                 190         


Pro Arg Pro Leu Thr Val Val Ala Val Ala Asn Val Met Ser Ala Val 
        195                 200                 205             


Cys Phe Gly Cys Arg Tyr Ser His Asp Asp Pro Glu Phe Arg Glu Leu 
    210                 215                 220                 


Leu Ser His Asn Glu Glu Phe Gly Arg Thr Val Gly Ala Gly Ser Leu 
225                 230                 235                 240 


Val Asp Val Met Pro Trp Leu Gln Tyr Phe Pro Asn Pro Val Arg Thr 
                245                 250                 255     


Val Phe Arg Glu Phe Glu Gln Leu Asn Arg Asn Phe Ser Asn Phe Ile 
            260                 265                 270         


Leu Asp Lys Phe Leu Arg His Cys Glu Ser Leu Arg Pro Gly Ala Ala 
        275                 280                 285             


Pro Arg Asp Met Met Asp Ala Phe Ile Leu Ser Ala Glu Lys Lys Ala 
    290                 295                 300                 


Ala Gly Asp Ser His Gly Gly Gly Ala Arg Leu Asp Leu Glu Asn Val 
305                 310                 315                 320 


Pro Ala Thr Ile Thr Asp Ile Phe Gly Ala Ser Gln Asp Thr Leu Ser 
                325                 330                 335     


Thr Ala Leu Gln Trp Leu Leu Leu Leu Phe Thr Arg Tyr Pro Asp Val 
            340                 345                 350         


Gln Thr Arg Val Gln Ala Glu Leu Asp Gln Val Val Gly Arg Asp Arg 
        355                 360                 365             


Leu Pro Cys Met Gly Asp Gln Pro Asn Leu Pro Tyr Val Leu Ala Phe 
    370                 375                 380                 


Leu Tyr Glu Ala Met Arg Phe Ser Ser Phe Val Pro Val Thr Ile Pro 
385                 390                 395                 400 


His Ala Thr Thr Ala Asn Thr Ser Val Leu Gly Tyr His Ile Pro Lys 
                405                 410                 415     


Asp Thr Val Val Phe Val Asn Gln Trp Ser Val Asn His Asp Pro Leu 
            420                 425                 430         


Lys Trp Pro Asn Pro Glu Asn Phe Asp Pro Ala Arg Phe Leu Asp Lys 
        435                 440                 445             


Asp Gly Leu Ile Asn Lys Asp Leu Thr Ser Arg Val Met Ile Phe Ser 
    450                 455                 460                 


Val Gly Lys Arg Arg Cys Ile Gly Glu Glu Leu Ser Lys Met Gln Leu 
465                 470                 475                 480 


Phe Leu Phe Ile Ser Ile Leu Ala His Gln Cys Asp Phe Arg Ala Asn 
                485                 490                 495     


Pro Asn Glu Pro Ala Lys Met Asn Phe Ser Tyr Gly Leu Thr Ile Lys 
            500                 505                 510         


Pro Lys Ser Phe Lys Val Asn Val Thr Leu Arg Glu Ser Met Glu Leu 
        515                 520                 525             


Leu Asp Ser Ala Val Gln Asn Leu Gln Ala Lys Glu Thr Cys Gln 
    530                 535                 540             


<210>  12
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Gly Thr Ser Leu Ser Pro Asn Asp Pro Trp Pro Leu Asn Pro Leu 
1               5                   10                  15      


Ser Ile Gln Gln Thr Thr Leu Leu Leu Leu Leu Ser Val Leu Ala Thr 
            20                  25                  30          


Val His Val Gly Gln Arg Leu Leu Arg Gln Arg Arg Arg Gln Leu Arg 
        35                  40                  45              


Ser Ala Pro Pro Gly Pro Phe Ala Trp Pro Leu Ile Gly Asn Ala Ala 
    50                  55                  60                  


Ala Val Gly Gln Ala Ala His Leu Ser Phe Ala Arg Leu Ala Arg Arg 
65                  70                  75                  80  


Tyr Gly Asp Val Phe Gln Ile Arg Leu Gly Ser Cys Pro Ile Val Val 
                85                  90                  95      


Leu Asn Gly Glu Arg Ala Ile His Gln Ala Leu Val Gln Gln Gly Ser 
            100                 105                 110         


Ala Phe Ala Asp Arg Pro Ala Phe Ala Ser Phe Arg Val Val Ser Gly 
        115                 120                 125             


Gly Arg Ser Met Ala Phe Gly His Tyr Ser Glu His Trp Lys Val Gln 
    130                 135                 140                 


Arg Arg Ala Ala His Ser Met Met Arg Asn Phe Phe Thr Arg Gln Pro 
145                 150                 155                 160 


Arg Ser Arg Gln Val Leu Glu Gly His Val Leu Ser Glu Ala Arg Glu 
                165                 170                 175     


Leu Val Ala Leu Leu Val Arg Gly Ser Ala Asp Gly Ala Phe Leu Asp 
            180                 185                 190         


Pro Arg Pro Leu Thr Val Val Ala Val Ala Asn Val Met Ser Ala Val 
        195                 200                 205             


Cys Phe Gly Cys Arg Tyr Ser His Asp Asp Pro Glu Phe Arg Glu Leu 
    210                 215                 220                 


Leu Ser His Asn Glu Glu Phe Gly Arg Thr Val Gly Ala Gly Ser Leu 
225                 230                 235                 240 


Val Asp Val Met Pro Trp Leu Gln Tyr Phe Pro Asn Pro Val Arg Thr 
                245                 250                 255     


Val Phe Arg Glu Phe Glu Gln Leu Asn Arg Asn Phe Ser Asn Phe Ile 
            260                 265                 270         


Leu Asp Lys Phe Leu Arg His Cys Glu Ser Leu Arg Pro Gly Ala Ala 
        275                 280                 285             


Pro Arg Asp Met Met Asp Ala Phe Ile Leu Ser Ala Glu Lys Lys Ala 
    290                 295                 300                 


Ala Gly Asp Ser His Gly Gly Gly Ala Arg Leu Asp Leu Glu Asn Val 
305                 310                 315                 320 


Pro Ala Thr Ile Thr Asp Ile Phe Gly Ala Ser Gln Asp Thr Leu Ser 
                325                 330                 335     


Thr Ala Leu Gln Trp Leu Leu Leu Leu Phe Thr Arg Tyr Pro Asp Val 
            340                 345                 350         


Gln Thr Arg Val Gln Ala Glu Leu Asp Gln Val Val Gly Arg Asp Arg 
        355                 360                 365             


Leu Pro Cys Met Gly Asp Gln Pro Asn Leu Pro Tyr Val Leu Ala Phe 
    370                 375                 380                 


Leu Tyr Glu Ala Met Arg Phe Ser Ser Phe Val Pro Val Thr Ile Pro 
385                 390                 395                 400 


His Ala Thr Thr Ala Asn Thr Ser Val Leu Gly Tyr His Ile Pro Lys 
                405                 410                 415     


Asp Thr Val Val Phe Val Asn Gln Trp Ser Val Asn His Asp Pro Val 
            420                 425                 430         


Lys Trp Pro Asn Pro Glu Asn Phe Asp Pro Ala Arg Phe Leu Asp Lys 
        435                 440                 445             


Asp Gly Leu Ile Asn Lys Asp Leu Thr Ser Arg Val Met Ile Phe Ser 
    450                 455                 460                 


Val Gly Lys Arg Arg Cys Ile Gly Glu Glu Leu Ser Lys Met Gln Leu 
465                 470                 475                 480 


Phe Leu Phe Ile Ser Ile Leu Ala His Gln Cys Asp Phe Arg Ala Asn 
                485                 490                 495     


Pro Asn Glu Pro Ala Lys Met Asn Phe Ser Tyr Gly Leu Thr Ile Lys 
            500                 505                 510         


Pro Lys Ser Phe Lys Val Asn Val Thr Leu Arg Glu Ser Met Glu Leu 
        515                 520                 525             


Leu Asp Ser Ala Val Gln Asn Leu Gln Ala Lys Glu Thr Cys Gln 
    530                 535                 540             


<210>  13
<211>  542
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Gly Thr Ser Leu Ser Pro Asn Asp Pro Trp Pro Leu Asn Pro Leu 
1               5                   10                  15      


Ser Ile Gln Gln Thr Thr Leu Leu Leu Leu Leu Ser Val Leu Ala Thr 
            20                  25                  30          


Val His Val Gly Gln Arg Leu Leu Arg Gln Arg Arg Arg Gln Leu Arg 
        35                  40                  45              


Ser Ala Pro Pro Gly Pro Phe Ala Trp Pro Leu Ile Gly Asn Ala Ala 
    50                  55                  60                  


Ala Val Gly Gln Ala Ala His Leu Ser Phe Ala Arg Leu Ala Arg Arg 
65                  70                  75                  80  


Tyr Gly Asp Val Phe Gln Ile Arg Leu Gly Ser Cys Pro Ile Val Val 
                85                  90                  95      


Leu Asn Gly Glu Arg Ala Ile His Gln Ala Leu Val Gln Gln Gly Ser 
            100                 105                 110         


Ala Phe Ala Asp Arg Pro Ala Phe Ala Ser Phe Arg Val Val Ser Gly 
        115                 120                 125             


Gly Arg Ser Met Ala Phe Gly His Tyr Ser Glu His Trp Lys Val Gln 
    130                 135                 140                 


Arg Arg Ala Ala His Ser Met Met Arg Asn Phe Phe Thr Arg Gln Pro 
145                 150                 155                 160 


Arg Ser Arg Gln Val Leu Glu Gly His Val Leu Ser Glu Ala Arg Glu 
                165                 170                 175     


Leu Val Ala Leu Leu Val Arg Gly Ser Ala Asp Gly Ala Phe Leu Asp 
            180                 185                 190         


Pro Arg Pro Leu Thr Val Val Ala Val Ala Asn Val Met Ser Ala Val 
        195                 200                 205             


Cys Phe Gly Cys Arg Tyr Ser His Asp Asp Pro Glu Phe Arg Glu Leu 
    210                 215                 220                 


Leu Ser His Asn Glu Glu Phe Gly Arg Thr Val Gly Ala Gly Ser Leu 
225                 230                 235                 240 


Val Asp Val Met Pro Trp Leu Gln Tyr Phe Pro Asn Pro Val Arg Thr 
                245                 250                 255     


Val Phe Arg Glu Phe Glu Gln Leu Asn Arg Asn Phe Ser Asn Phe Ile 
            260                 265                 270         


Leu Asp Lys Phe Leu Arg His Cys Glu Ser Leu Arg Pro Gly Ala Ala 
        275                 280                 285             


Pro Arg Asp Met Met Asp Ala Phe Ile Leu Ser Ala Glu Lys Lys Ala 
    290                 295                 300                 


Ala Gly Asp Ser His Gly Gly Gly Ala Arg Leu Asp Leu Glu Asn Val 
305                 310                 315                 320 


Pro Ala Thr Ile Thr Asp Ile Phe Gly Ala Ser Gln Asp Thr Leu Ser 
                325                 330                 335     


Thr Ala Leu Gln Trp Leu Leu Leu Leu Phe Thr Arg Tyr Pro Asp Val 
            340                 345                 350         


Gln Thr Arg Val Gln Ala Glu Leu Asp Gln Val Val Gly Arg Asp Arg 
        355                 360                 365             


Leu Pro Cys Met Gly Asp Gln Pro Asn Leu Pro Tyr Val Leu Ala Phe 
    370                 375                 380                 


Leu Tyr Glu Ala Met Arg Phe Ser Ser Phe Val Pro Val Thr Ile Pro 
385                 390                 395                 400 


His Ala Thr Thr Ala Asn Thr Ser Val Leu Gly Tyr His Ile Pro Lys 
                405                 410                 415     


Asp Thr Val Val Phe Val Asn Gln Trp Ser Val Asn His Asp Pro Leu 
            420                 425                 430         


Lys Trp Pro Asn Pro Glu Asn Phe Asp Pro Ala Arg Phe Leu Asp Lys 
        435                 440                 445             


Asp Gly Leu Ile Ser Lys Asp Leu Thr Ser Arg Val Met Ile Phe Ser 
    450                 455                 460                 


Val Gly Lys Arg Arg Cys Ile Gly Glu Glu Leu Ser Lys Met Gln Leu 
465                 470                 475                 480 


Phe Leu Phe Ile Ser Ile Leu Ala His Gln Cys Asp Phe Arg Ala Asn 
                485                 490                 495     


Pro Asn Glu Pro Ala Lys Met Asn Phe Ser Tyr Gly Leu Thr Ile Lys 
            500                 505                 510         


Pro Lys Ser Phe Lys Val Asn Val Thr Leu Arg Glu Ser Met Glu Leu 
        515                 520                 525             


Leu Asp Ser Ala Val Gln Asn Leu Gln Ala Lys Glu Thr Cys 
    530                 535                 540         


<210>  14
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Completely synthesized

<400>  14
aaatcaaaac agatacccgg atg                                               23


<210>  15
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Completely synthesized.

<400>  15
tccggcctct cacttgca                                                     18


<210>  16
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Completely synthesized.

<400>  16
tgaatgaact gcaggacgag                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Completely synthesized.

<400>  17
acgacttggg cttaatggtc                                                   20


