                         SEQUENCE LISTING

<110>  The Government of the United States of America as 
       represented by the Secretary of the Department of Health and 
       Human Services, Centers for Disease Control and Prevention
 
<120>  DETECTION OF SUBJECT BIOMARKER DIAGNOSTIC ASSAY FOR DENGUE FEVER 
       AND THE DIFFERENTIATION OF DENGUE HEMORRHAGIC FEVER

<130>  CDC-17252/38

<150>  US 61/443,554
<151>  2011-02-16

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  478
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Pro Leu Arg Pro Leu Leu Ile Leu Ala Leu Leu Ala Trp Val 
1               5                   10                  15      


Ala Leu Ala Asp Gln Glu Ser Cys Lys Gly Arg Cys Thr Glu Gly Phe 
            20                  25                  30          


Asn Val Asp Lys Lys Cys Gln Cys Asp Glu Leu Cys Ser Tyr Tyr Gln 
        35                  40                  45              


Ser Cys Cys Thr Asp Tyr Thr Ala Glu Cys Lys Pro Gln Val Thr Arg 
    50                  55                  60                  


Gly Asp Val Phe Thr Met Pro Glu Asp Glu Tyr Thr Val Tyr Asp Asp 
65                  70                  75                  80  


Gly Glu Glu Lys Asn Asn Ala Thr Val His Glu Gln Val Gly Gly Pro 
                85                  90                  95      


Ser Leu Thr Ser Asp Leu Gln Ala Gln Ser Lys Gly Asn Pro Glu Gln 
            100                 105                 110         


Thr Pro Val Leu Lys Pro Glu Glu Glu Ala Pro Ala Pro Glu Val Gly 
        115                 120                 125             


Ala Ser Lys Pro Glu Gly Ile Asp Ser Arg Pro Glu Thr Leu His Pro 
    130                 135                 140                 


Gly Arg Pro Gln Pro Pro Ala Glu Glu Glu Leu Cys Ser Gly Lys Pro 
145                 150                 155                 160 


Phe Asp Ala Phe Thr Asp Leu Lys Asn Gly Ser Leu Phe Ala Phe Arg 
                165                 170                 175     


Gly Gln Tyr Cys Tyr Glu Leu Asp Glu Lys Ala Val Arg Pro Gly Tyr 
            180                 185                 190         


Pro Lys Leu Ile Arg Asp Val Trp Gly Ile Glu Gly Pro Ile Asp Ala 
        195                 200                 205             


Ala Phe Thr Arg Ile Asn Cys Gln Gly Lys Thr Tyr Leu Phe Lys Gly 
    210                 215                 220                 


Ser Gln Tyr Trp Arg Phe Glu Asp Gly Val Leu Asp Pro Asp Tyr Pro 
225                 230                 235                 240 


Arg Asn Ile Ser Asp Gly Phe Asp Gly Ile Pro Asp Asn Val Asp Ala 
                245                 250                 255     


Ala Leu Ala Leu Pro Ala His Ser Tyr Ser Gly Arg Glu Arg Val Tyr 
            260                 265                 270         


Phe Phe Lys Gly Lys Gln Tyr Trp Glu Tyr Gln Phe Gln His Gln Pro 
        275                 280                 285             


Ser Gln Glu Glu Cys Glu Gly Ser Ser Leu Ser Ala Val Phe Glu His 
    290                 295                 300                 


Phe Ala Met Met Gln Arg Asp Ser Trp Glu Asp Ile Phe Glu Leu Leu 
305                 310                 315                 320 


Phe Trp Gly Arg Thr Ser Ala Gly Thr Arg Gln Pro Gln Phe Ile Ser 
                325                 330                 335     


Arg Asp Trp His Gly Val Pro Gly Gln Val Asp Ala Ala Met Ala Gly 
            340                 345                 350         


Arg Ile Tyr Ile Ser Gly Met Ala Pro Arg Pro Ser Leu Ala Lys Lys 
        355                 360                 365             


Gln Arg Phe Arg His Arg Asn Arg Lys Gly Tyr Arg Ser Gln Arg Gly 
    370                 375                 380                 


His Ser Arg Gly Arg Asn Gln Asn Ser Arg Arg Pro Ser Arg Ala Thr 
385                 390                 395                 400 


Trp Leu Ser Leu Phe Ser Ser Glu Glu Ser Asn Leu Gly Ala Asn Asn 
                405                 410                 415     


Tyr Asp Asp Tyr Arg Met Asp Trp Leu Val Pro Ala Thr Cys Glu Pro 
            420                 425                 430         


Ile Gln Ser Val Phe Phe Phe Ser Gly Asp Lys Tyr Tyr Arg Val Asn 
        435                 440                 445             


Leu Arg Thr Arg Arg Val Asp Thr Val Asp Pro Pro Tyr Pro Arg Ser 
    450                 455                 460                 


Ile Ala Gln Tyr Trp Leu Gly Cys Pro Ala Pro Gly His Leu 
465                 470                 475             


<210>  2
<211>  1434
<212>  DNA
<213>  Homo sapiens

<400>  2
atggcacccc tgagacccct tctcatactg gccctgctgg catgggttgc tctggctgac       60

caagagtcat gcaagggccg ctgcactgag ggcttcaacg tggacaagaa gtgccagtgt      120

gacgagctct gctcttacta ccagagctgc tgcacagact atacggctga gtgcaagccc      180

caagtgactc gcggggatgt gttcactatg ccggaggatg agtacacggt ctatgacgat      240

ggcgaggaga aaaacaatgc cactgtccat gaacaggtgg ggggcccctc cctgacctct      300

gacctccagg cccagtccaa agggaatcct gagcagacac ctgttctgaa acctgaggaa      360

gaggcccctg cgcctgaggt gggcgcctct aagcctgagg ggatagactc aaggcctgag      420

acccttcatc cagggagacc tcagccccca gcagaggagg agctgtgcag tgggaagccc      480

ttcgacgcct tcaccgacct caagaacggt tccctctttg ccttccgagg gcagtactgc      540

tatgaactgg acgaaaaggc agtgaggcct gggtacccca agctcatccg agatgtctgg      600

ggcatcgagg gccccatcga tgccgccttc acccgcatca actgtcaggg gaagacctac      660

ctcttcaagg gtagtcagta ctggcgcttt gaggatggtg tcctggaccc tgattacccc      720

cgaaatatct ctgacggctt cgatggcatc ccggacaacg tggatgcagc cttggccctc      780

cctgcccata gctacagtgg ccgggagcgg gtctacttct tcaaggggaa acagtactgg      840

gagtaccagt tccagcacca gcccagtcag gaggagtgtg aaggcagctc cctgtcggct      900

gtgtttgaac actttgccat gatgcagcgg gacagctggg aggacatctt cgagcttctc      960

ttctggggca gaacctctgc tggtaccaga cagccccagt tcattagccg ggactggcac     1020

ggtgtgccag ggcaagtgga cgcagccatg gctggccgca tctacatctc aggcatggca     1080

ccccgcccct ccttggccaa gaaacaaagg tttaggcatc gcaaccgcaa aggctaccgt     1140

tcacaacgag gccacagccg tggccgcaac cagaactccc gccggccatc ccgcgccacg     1200

tggctgtcct tgttctccag tgaggagagc aacttgggag ccaacaacta tgatgactac     1260

aggatggact ggcttgtgcc tgccacctgt gaacccatcc agagtgtctt cttcttctct     1320

ggagacaagt actaccgagt caatcttcgc acacggcgag tggacactgt ggaccctccc     1380

tacccacgct ccatcgctca gtactggctg ggctgcccag ctcctggcca tctg           1434


<210>  3
<211>  459
<212>  PRT
<213>  Homo sapiens

<400>  3

Asp Gln Glu Ser Cys Lys Gly Arg Cys Thr Glu Gly Phe Asn Val Asp 
1               5                   10                  15      


Lys Lys Cys Gln Cys Asp Glu Leu Cys Ser Tyr Tyr Gln Ser Cys Cys 
            20                  25                  30          


Thr Asp Tyr Thr Ala Glu Cys Lys Pro Gln Val Thr Arg Gly Asp Val 
        35                  40                  45              


Phe Thr Met Pro Glu Asp Glu Tyr Thr Val Tyr Asp Asp Gly Glu Glu 
    50                  55                  60                  


Lys Asn Asn Ala Thr Val His Glu Gln Val Gly Gly Pro Ser Leu Thr 
65                  70                  75                  80  


Ser Asp Leu Gln Ala Gln Ser Lys Gly Asn Pro Glu Gln Thr Pro Val 
                85                  90                  95      


Leu Lys Pro Glu Glu Glu Ala Pro Ala Pro Glu Val Gly Ala Ser Lys 
            100                 105                 110         


Pro Glu Gly Ile Asp Ser Arg Pro Glu Thr Leu His Pro Gly Arg Pro 
        115                 120                 125             


Gln Pro Pro Ala Glu Glu Glu Leu Cys Ser Gly Lys Pro Phe Asp Ala 
    130                 135                 140                 


Phe Thr Asp Leu Lys Asn Gly Ser Leu Phe Ala Phe Arg Gly Gln Tyr 
145                 150                 155                 160 


Cys Tyr Glu Leu Asp Glu Lys Ala Val Arg Pro Gly Tyr Pro Lys Leu 
                165                 170                 175     


Ile Arg Asp Val Trp Gly Ile Glu Gly Pro Ile Asp Ala Ala Phe Thr 
            180                 185                 190         


Arg Ile Asn Cys Gln Gly Lys Thr Tyr Leu Phe Lys Gly Ser Gln Tyr 
        195                 200                 205             


Trp Arg Phe Glu Asp Gly Val Leu Asp Pro Asp Tyr Pro Arg Asn Ile 
    210                 215                 220                 


Ser Asp Gly Phe Asp Gly Ile Pro Asp Asn Val Asp Ala Ala Leu Ala 
225                 230                 235                 240 


Leu Pro Ala His Ser Tyr Ser Gly Arg Glu Arg Val Tyr Phe Phe Lys 
                245                 250                 255     


Gly Lys Gln Tyr Trp Glu Tyr Gln Phe Gln His Gln Pro Ser Gln Glu 
            260                 265                 270         


Glu Cys Glu Gly Ser Ser Leu Ser Ala Val Phe Glu His Phe Ala Met 
        275                 280                 285             


Met Gln Arg Asp Ser Trp Glu Asp Ile Phe Glu Leu Leu Phe Trp Gly 
    290                 295                 300                 


Arg Thr Ser Ala Gly Thr Arg Gln Pro Gln Phe Ile Ser Arg Asp Trp 
305                 310                 315                 320 


His Gly Val Pro Gly Gln Val Asp Ala Ala Met Ala Gly Arg Ile Tyr 
                325                 330                 335     


Ile Ser Gly Met Ala Pro Arg Pro Ser Leu Ala Lys Lys Gln Arg Phe 
            340                 345                 350         


Arg His Arg Asn Arg Lys Gly Tyr Arg Ser Gln Arg Gly His Ser Arg 
        355                 360                 365             


Gly Arg Asn Gln Asn Ser Arg Arg Pro Ser Arg Ala Thr Trp Leu Ser 
    370                 375                 380                 


Leu Phe Ser Ser Glu Glu Ser Asn Leu Gly Ala Asn Asn Tyr Asp Asp 
385                 390                 395                 400 


Tyr Arg Met Asp Trp Leu Val Pro Ala Thr Cys Glu Pro Ile Gln Ser 
                405                 410                 415     


Val Phe Phe Phe Ser Gly Asp Lys Tyr Tyr Arg Val Asn Leu Arg Thr 
            420                 425                 430         


Arg Arg Val Asp Thr Val Asp Pro Pro Tyr Pro Arg Ser Ile Ala Gln 
        435                 440                 445             


Tyr Trp Leu Gly Cys Pro Ala Pro Gly His Leu 
    450                 455                 


<210>  4
<211>  1377
<212>  DNA
<213>  Homo sapiens

<400>  4
gaccaagagt catgcaaggg ccgctgcact gagggcttca acgtggacaa gaagtgccag       60

tgtgacgagc tctgctctta ctaccagagc tgctgcacag actatacggc tgagtgcaag      120

ccccaagtga ctcgcgggga tgtgttcact atgccggagg atgagtacac ggtctatgac      180

gatggcgagg agaaaaacaa tgccactgtc catgaacagg tggggggccc ctccctgacc      240

tctgacctcc aggcccagtc caaagggaat cctgagcaga cacctgttct gaaacctgag      300

gaagaggccc ctgcgcctga ggtgggcgcc tctaagcctg aggggataga ctcaaggcct      360

gagacccttc atccagggag acctcagccc ccagcagagg aggagctgtg cagtgggaag      420

cccttcgacg ccttcaccga cctcaagaac ggttccctct ttgccttccg agggcagtac      480

tgctatgaac tggacgaaaa ggcagtgagg cctgggtacc ccaagctcat ccgagatgtc      540

tggggcatcg agggccccat cgatgccgcc ttcacccgca tcaactgtca ggggaagacc      600

tacctcttca agggtagtca gtactggcgc tttgaggatg gtgtcctgga ccctgattac      660

ccccgaaata tctctgacgg cttcgatggc atcccggaca acgtggatgc agccttggcc      720

ctccctgccc atagctacag tggccgggag cgggtctact tcttcaaggg gaaacagtac      780

tgggagtacc agttccagca ccagcccagt caggaggagt gtgaaggcag ctccctgtcg      840

gctgtgtttg aacactttgc catgatgcag cgggacagct gggaggacat cttcgagctt      900

ctcttctggg gcagaacctc tgctggtacc agacagcccc agttcattag ccgggactgg      960

cacggtgtgc cagggcaagt ggacgcagcc atggctggcc gcatctacat ctcaggcatg     1020

gcaccccgcc cctccttggc caagaaacaa aggtttaggc atcgcaaccg caaaggctac     1080

cgttcacaac gaggccacag ccgtggccgc aaccagaact cccgccggcc atcccgcgcc     1140

acgtggctgt ccttgttctc cagtgaggag agcaacttgg gagccaacaa ctatgatgac     1200

tacaggatgg actggcttgt gcctgccacc tgtgaaccca tccagagtgt cttcttcttc     1260

tctggagaca agtactaccg agtcaatctt cgcacacggc gagtggacac tgtggaccct     1320

ccctacccac gctccatcgc tcagtactgg ctgggctgcc cagctcctgg ccatctg        1377


