                         SEQUENCE LISTING

<110>  Thelial Technologies S.A.
       Hampson, Richard  John
       De Oliveira Marques, Virginia Mylena
       Martinho, Rui Goncalo Viegas Russo da Conceicao
 
<120>  MONOMERIC BACTERIAL ACTIN ADP-RIBOSYLTRANSFERASES AS CANCER 
       CHEMOTHERAPEUTICS

<130>  7526/83605-PCT/GJG/REB

<150>  US 61/603,412
<151>  2012-02-27

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  1428
<212>  DNA
<213>  Aeromonas salmonicida

<400>  1
atgcagattc aagcaaacac cgtcggcaca caggccgtcg ctcaccacag tgatgccacg       60

accggagttg gccggatggg tcagatggag gcgcgtcagg tcgccaccgg acaagatgcg      120

atcctgctgg gcagtcgcag cgaaccgcaa aaagggcagg ggctgctctc gcgactgggg      180

gcccagctgg cccgcccgtt cgtggccatc aaagagtgga tcagcaacct gctggggacg      240

gacaagcgtg ccgctgcgcc gaaggcgcaa accgccgttt cccccgagga tcttcagcga      300

ctgatgaagc aggctgcatt tggtagctcg ctgggtggct tcgccaaggc ggacgtgttg      360

aacaacatca caggcgaaca attgggcaag gatcacgcca gtctggcgac cggcaatggc      420

cccctgcgct ctctctgcac cgcgttgcag gccgttgtca taggatctca gcaaccgcaa      480

ctccgggagt tggctaccgg gctgctggcc cgccccatcg ccggtatccc gctccagcag      540

tgggggtcgg taggcggcaa ggtgaccgag ctgctcacca gcgccccccc cgaactgttg      600

aaggaggcta tgagccagct acacaccgcg atgggtgaag ttgccgacct gcagcgcgct      660

gtaaaggcag aagttgctgg cgaaccggcg cgaagcgcga ccacagcggc cgctgtggcg      720

ccgctccaaa gcggtgagag cgaagttaac gttgagcctg ccgacaaggc gctggcagag      780

ggcttgcagg agcaattcgg cctggaggcc gagcaatatc tgggtgaaca gccccacggt      840

acttacagcg atgctgaagt gatggcgctt gggctctaca ccaacggcga ataccagcac      900

ctgaatcgct cgctgcgtca ggaaaagcag ctggatgcag ggcaagcgtt gatcgatcag      960

ggtatgtcca ccgcttttga gaaaagtacc cccaccgagc agttgatcaa gaccttccgc     1020

ggtacccacg gcggcgatgc gttcaacgag gtggcagagg ggcaagtcgg tcatgatgtc     1080

gcttatcttt ccacctctcg ggatcccaag gtggcaacca actttggtgg ttcaggctcc     1140

atatccacga tatttggccg ctcggggatc gatgtcagcg acatatccgt tgaaggtgac     1200

gagcaggaga tcctctataa caaagagact gatatgcggg tattgctcag tgccaaagat     1260

gaacggggcg tcacccggcg ggtactggaa gaggcctcgc tgggggaaca aagcggccac     1320

agcaaggggc tgctggacgg gctggatctg gcaagaggag cgggcggtgc cgacaagccg     1380

caagagcaag atatccgtct gaagatgcgc gggctcgatt tggcgtga                  1428


<210>  2
<211>  475
<212>  PRT
<213>  Aeromonas salmonicida

<400>  2

Met Gln Ile Gln Ala Asn Thr Val Gly Thr Gln Ala Val Ala His His 
1               5                   10                  15      


Ser Asp Ala Thr Thr Gly Val Gly Arg Met Gly Gln Met Glu Ala Arg 
            20                  25                  30          


Gln Val Ala Thr Gly Gln Asp Ala Ile Leu Leu Gly Ser Arg Ser Glu 
        35                  40                  45              


Pro Gln Lys Gly Gln Gly Leu Leu Ser Arg Leu Gly Ala Gln Leu Ala 
    50                  55                  60                  


Arg Pro Phe Val Ala Ile Lys Glu Trp Ile Ser Asn Leu Leu Gly Thr 
65                  70                  75                  80  


Asp Lys Arg Ala Ala Ala Pro Lys Ala Gln Thr Ala Val Ser Pro Glu 
                85                  90                  95      


Asp Leu Gln Arg Leu Met Lys Gln Ala Ala Phe Gly Ser Ser Leu Gly 
            100                 105                 110         


Gly Phe Ala Lys Ala Asp Val Leu Asn Asn Ile Thr Gly Glu Gln Leu 
        115                 120                 125             


Gly Lys Asp His Ala Ser Leu Ala Thr Gly Asn Gly Pro Leu Arg Ser 
    130                 135                 140                 


Leu Cys Thr Ala Leu Gln Ala Val Val Ile Gly Ser Gln Gln Pro Gln 
145                 150                 155                 160 


Leu Arg Glu Leu Ala Thr Gly Leu Leu Ala Arg Pro Ile Ala Gly Ile 
                165                 170                 175     


Pro Leu Gln Gln Trp Gly Ser Val Gly Gly Lys Val Thr Glu Leu Leu 
            180                 185                 190         


Thr Ser Ala Pro Pro Glu Leu Leu Lys Glu Ala Met Ser Gln Leu His 
        195                 200                 205             


Thr Ala Met Gly Glu Val Ala Asp Leu Gln Arg Ala Val Lys Ala Glu 
    210                 215                 220                 


Val Ala Gly Glu Pro Ala Arg Ser Ala Thr Thr Ala Ala Ala Val Ala 
225                 230                 235                 240 


Pro Leu Gln Ser Gly Glu Ser Glu Val Asn Val Glu Pro Ala Asp Lys 
                245                 250                 255     


Ala Leu Ala Glu Gly Leu Gln Glu Gln Phe Gly Leu Glu Ala Glu Gln 
            260                 265                 270         


Tyr Leu Gly Glu Gln Pro His Gly Thr Tyr Ser Asp Ala Glu Val Met 
        275                 280                 285             


Ala Leu Gly Leu Tyr Thr Asn Gly Glu Tyr Gln His Leu Asn Arg Ser 
    290                 295                 300                 


Leu Arg Gln Glu Lys Gln Leu Asp Ala Gly Gln Ala Leu Ile Asp Gln 
305                 310                 315                 320 


Gly Met Ser Thr Ala Phe Glu Lys Ser Thr Pro Thr Glu Gln Leu Ile 
                325                 330                 335     


Lys Thr Phe Arg Gly Thr His Gly Gly Asp Ala Phe Asn Glu Val Ala 
            340                 345                 350         


Glu Gly Gln Val Gly His Asp Val Ala Tyr Leu Ser Thr Ser Arg Asp 
        355                 360                 365             


Pro Lys Val Ala Thr Asn Phe Gly Gly Ser Gly Ser Ile Ser Thr Ile 
    370                 375                 380                 


Phe Gly Arg Ser Gly Ile Asp Val Ser Asp Ile Ser Val Glu Gly Asp 
385                 390                 395                 400 


Glu Gln Glu Ile Leu Tyr Asn Lys Glu Thr Asp Met Arg Val Leu Leu 
                405                 410                 415     


Ser Ala Lys Asp Glu Arg Gly Val Thr Arg Arg Val Leu Glu Glu Ala 
            420                 425                 430         


Ser Leu Gly Glu Gln Ser Gly His Ser Lys Gly Leu Leu Asp Gly Leu 
        435                 440                 445             


Asp Leu Ala Arg Gly Ala Gly Gly Ala Asp Lys Pro Gln Glu Gln Asp 
    450                 455                 460                 


Ile Arg Leu Lys Met Arg Gly Leu Asp Leu Ala 
465                 470                 475 


<210>  3
<211>  1770
<212>  DNA
<213>  Salmonella enterica

<400>  3
atgttgatac taaatggttt ttcatctgcc actttagcgc tgatcactcc ccctttcctg       60

ccaaaagggg gcaaggcgct gagtcagtca ggccctgacg gcctagccag tataacgctg      120

cctctgccca tcagcgccga acgcggcttt gcgcctgcgc tggcgctgca ctacagcagc      180

ggtggcggca atggcccctt cggcgtgggc tggtcctgcg cgacaatgag cattgcccgc      240

cgcaccagcc atggcgtgcc gcagtataac gacagcgatg agtttctggg gccggacgga      300

gaagtgctgg ttcaaacgct cagcaccggt gatgccccca atcccgtcac ctgcttcgcg      360

tacggtgacg tatcgttccc gcaaagctac acggtgaccc gctatcagcc ccgcacggag      420

agcagttttt atcgcctgga gtactgggtg ggcaacagca acggcgatga tttctggtta      480

ctgcatgaca gtaacggcat cctgcacctg ctggggaaaa ccgccgcagc acgcctcagc      540

gatccgcagg ccgcctctca tacggcgcaa tggctggttg aggagtcggt gacccctgcc      600

ggcgagcata tctattactc ctacttggcg gagaacggtg acaatgtgga cctcaatggg      660

aacgaggccg gacgcgatcg cagcgccatg cgctatctca gcaaggtaca gtatggcaac      720

gcgacccccg ccgccgatct gtacctctgg actagcgcca cacccgcggt acagtggctg      780

ttcaccctag tgtttgacta cggcgaacgt ggtgtagatc cacaggtacc gcctgcattc      840

actgctcaga acagctggct cgcccgccag gatcccttct ccctgtataa ctacggcttt      900

gagatccgcc tccatcgcct gtgccgccaa gtcctgatgt tccaccactt tcctgatgaa      960

ctgggtgaag ccgatacgct ggtttcccgt ctgctgctgg agtatgacga aaatccgata     1020

ctgacacagc tttgcgctgc tcggacgctg gcctatgaag gcgacggtta tagaagagct     1080

cctgtcaaca atatgatgcc accgcctcct ccgatgatgg gaggtaattc atctcgacca     1140

aaatcaaaat gggcgattgt agaggaatca aagcagattc aagctctgag gtactattca     1200

gctcaagggt acagtgtgat taataaatat ttacgtgggg atgattatcc tgaaacacag     1260

gcaaaagaaa ctctgctctc cagagactat ctttccacaa atgaacccag tgatgaggag     1320

tttaaaaatg ccatgtcagt ttatataaat gatattgcgg agggattaag ttcacttccc     1380

gaaacagatc acagagtcgt ataccggggc ctgaagcttg ataagcccgc attatcggat     1440

gtgctgaagg aatacactac tataggtaat ataataatag ataaagcttt tatgagtaca     1500

tcgccagata aggcatggat aaatgacact attctcaaca tatacctaga aaaaggacat     1560

aaaggtagaa tactcggaga tgttgcacat tttaagggag aggcagagat gcttttccct     1620

ccaaatacta aactcaaaat cgaaagcatt gtaaattgtg gatcccaaga ctttgcaagc     1680

cagcttagta agctgagatt aagtgatgat gcaactgctg acacaaacag gataaaaaga     1740

ataataaaca tgagggtact caactcatag                                      1770


<210>  4
<211>  591
<212>  PRT
<213>  Salmonella enterica

<400>  4

Met Leu Ile Leu Asn Gly Phe Ser Ser Ala Thr Leu Ala Leu Ile Thr 
1               5                   10                  15      


Pro Pro Phe Leu Pro Lys Gly Gly Lys Ala Leu Ser Gln Ser Gly Pro 
            20                  25                  30          


Asp Gly Leu Ala Ser Ile Thr Leu Pro Leu Pro Ile Ser Ala Glu Arg 
        35                  40                  45              


Gly Phe Ala Pro Ala Leu Ala Leu His Tyr Ser Ser Gly Gly Gly Asn 
    50                  55                  60                  


Gly Pro Phe Gly Val Gly Trp Ser Cys Ala Thr Met Ser Ile Ala Arg 
65                  70                  75                  80  


Arg Thr Ser His Gly Val Pro Gln Tyr Asn Asp Ser Asp Glu Phe Leu 
                85                  90                  95      


Gly Pro Asp Gly Glu Val Leu Val Gln Thr Leu Ser Thr Gly Asp Ala 
            100                 105                 110         


Pro Asn Pro Val Thr Cys Phe Ala Tyr Gly Asp Val Ser Phe Pro Gln 
        115                 120                 125             


Ser Tyr Thr Val Thr Arg Tyr Gln Pro Arg Thr Glu Ser Ser Phe Tyr 
    130                 135                 140                 


Arg Leu Glu Tyr Trp Val Gly Asn Ser Asn Gly Asp Asp Phe Trp Leu 
145                 150                 155                 160 


Leu His Asp Ser Asn Gly Ile Leu His Leu Leu Gly Lys Thr Ala Ala 
                165                 170                 175     


Ala Arg Leu Ser Asp Pro Gln Ala Ala Ser His Thr Ala Gln Trp Leu 
            180                 185                 190         


Val Glu Glu Ser Val Thr Pro Ala Gly Glu His Ile Tyr Tyr Ser Tyr 
        195                 200                 205             


Leu Ala Glu Asn Gly Asp Asn Val Asp Leu Asn Gly Asn Glu Ala Gly 
    210                 215                 220                 


Arg Asp Arg Ser Ala Met Arg Tyr Leu Ser Lys Val Gln Tyr Gly Asn 
225                 230                 235                 240 


Ala Thr Pro Ala Ala Asp Leu Tyr Leu Trp Thr Ser Ala Thr Pro Ala 
                245                 250                 255     


Val Gln Trp Leu Phe Thr Leu Val Phe Asp Tyr Gly Glu Arg Gly Val 
            260                 265                 270         


Asp Pro Gln Val Pro Pro Ala Phe Thr Ala Gln Asn Ser Trp Leu Ala 
        275                 280                 285             


Arg Gln Asp Pro Phe Ser Leu Tyr Asn Tyr Gly Phe Glu Ile Arg Leu 
    290                 295                 300                 


His Arg Leu Cys Arg Gln Val Leu Met Phe His His Phe Pro Asp Glu 
305                 310                 315                 320 


Leu Gly Glu Ala Asp Thr Leu Val Ser Arg Leu Leu Leu Glu Tyr Asp 
                325                 330                 335     


Glu Asn Pro Ile Leu Thr Gln Leu Cys Ala Ala Arg Thr Leu Ala Tyr 
            340                 345                 350         


Glu Gly Asp Gly Tyr Arg Arg Ala Pro Val Asn Asn Met Met Pro Pro 
        355                 360                 365             


Pro Pro Pro Pro Pro Met Met Gly Gly Asn Ser Ser Arg Pro Lys Ser 
    370                 375                 380                 


Lys Trp Ala Ile Val Glu Glu Ser Lys Gln Ile Gln Ala Leu Arg Tyr 
385                 390                 395                 400 


Tyr Ser Ala Gln Gly Tyr Ser Val Ile Asn Lys Tyr Leu Arg Gly Asp 
                405                 410                 415     


Asp Tyr Pro Glu Thr Gln Ala Lys Glu Thr Leu Leu Ser Arg Asp Tyr 
            420                 425                 430         


Leu Ser Thr Asn Glu Pro Ser Asp Glu Glu Phe Lys Asn Ala Met Ser 
        435                 440                 445             


Val Tyr Ile Asn Asp Ile Ala Glu Gly Leu Ser Ser Leu Pro Glu Thr 
    450                 455                 460                 


Asp His Arg Val Val Tyr Arg Gly Leu Lys Leu Asp Lys Pro Ala Leu 
465                 470                 475                 480 


Ser Asp Val Leu Lys Glu Tyr Thr Thr Ile Gly Asn Ile Ile Ile Asp 
                485                 490                 495     


Lys Ala Phe Met Ser Thr Ser Pro Asp Lys Ala Trp Ile Asn Asp Thr 
            500                 505                 510         


Ile Leu Asn Ile Tyr Leu Glu Lys Gly His Lys Gly Arg Ile Leu Gly 
        515                 520                 525             


Asp Val Ala His Phe Lys Gly Glu Ala Glu Met Leu Phe Pro Pro Asn 
    530                 535                 540                 


Thr Lys Leu Lys Ile Glu Ser Ile Val Asn Cys Gly Ser Gln Asp Phe 
545                 550                 555                 560 


Ala Ser Gln Leu Ser Lys Leu Arg Leu Ser Asp Asp Ala Thr Ala Asp 
                565                 570                 575     


Thr Asn Arg Ile Lys Arg Ile Ile Asn Met Arg Val Leu Asn Ser 
            580                 585                 590     


<210>  5
<211>  430
<212>  PRT
<213>  Clostridium botulinum

<400>  5

Met Pro Ile Ile Lys Glu Pro Ile Asp Phe Ile Asn Lys Pro Glu Ser 
1               5                   10                  15      


Glu Ala Gln Lys Trp Gly Lys Glu Glu Glu Lys Arg Trp Phe Thr Lys 
            20                  25                  30          


Leu Asn Asn Leu Glu Glu Val Ala Val Asn Gln Leu Lys Thr Lys Glu 
        35                  40                  45              


Asp Lys Thr Lys Ile Asp Asn Phe Ser Thr Asp Ile Leu Phe Ser Ser 
    50                  55                  60                  


Leu Thr Ala Ile Glu Ile Met Lys Glu Asp Glu Asn Gln Asn Leu Phe 
65                  70                  75                  80  


Asp Val Glu Arg Ile Arg Glu Ala Leu Leu Lys Asn Thr Leu Asp Arg 
                85                  90                  95      


Glu Val Ile Gly Tyr Val Asn Phe Thr Pro Lys Glu Leu Gly Ile Asn 
            100                 105                 110         


Phe Ser Ile Arg Asp Val Glu Leu Asn Arg Asp Ile Ser Asp Glu Ile 
        115                 120                 125             


Leu Asp Lys Val Arg Gln Gln Ile Ile Asn Gln Glu Tyr Thr Lys Phe 
    130                 135                 140                 


Ser Phe Val Ser Leu Gly Leu Asn Asp Asn Ser Ile Asp Glu Ser Ile 
145                 150                 155                 160 


Pro Val Ile Val Lys Thr Arg Val Pro Thr Thr Phe Asn Tyr Gly Val 
                165                 170                 175     


Leu Asn Asn Lys Glu Thr Val Ser Leu Leu Leu Asn Gln Gly Phe Ser 
            180                 185                 190         


Ile Ile Pro Glu Ser Ala Ile Ile Thr Thr Ile Lys Gly Lys Asp Tyr 
        195                 200                 205             


Ile Leu Ile Glu Gly Ser Leu Ser Gln Glu Leu Asp Phe Tyr Asn Lys 
    210                 215                 220                 


Gly Ser Glu Ala Trp Gly Glu Lys Asn Tyr Gly Asp Tyr Val Ser Lys 
225                 230                 235                 240 


Leu Ser Gln Glu Gln Leu Gly Ala Leu Glu Gly Tyr Leu His Ser Asp 
                245                 250                 255     


Tyr Lys Ala Ile Asn Ser Tyr Leu Arg Asn Asn Arg Val Pro Asn Asn 
            260                 265                 270         


Asp Glu Leu Asn Lys Lys Ile Glu Leu Ile Ser Ser Ala Leu Ser Val 
        275                 280                 285             


Lys Pro Ile Pro Glu Thr Leu Ile Ala Tyr Arg Arg Val Asp Gly Ile 
    290                 295                 300                 


Pro Phe Asp Leu Pro Ser Asp Phe Ser Phe Asp Lys Lys Glu Asn Gly 
305                 310                 315                 320 


Glu Ile Ile Ala Asp Lys Thr Lys Leu Asn Glu Phe Ile Asp Lys Trp 
                325                 330                 335     


Thr Gly Lys Glu Ile Glu Asn Leu Ser Phe Ser Ser Thr Ser Leu Lys 
            340                 345                 350         


Ser Thr Pro Leu Ser Phe Ser Lys Ser Arg Phe Ile Phe Arg Leu Arg 
        355                 360                 365             


Leu Ser Glu Gly Thr Ile Gly Ala Phe Ile Tyr Gly Phe Ser Gly Phe 
    370                 375                 380                 


Gln Asp Glu Gln Glu Ile Leu Leu Asn Lys Asn Ser Thr Phe Lys Ile 
385                 390                 395                 400 


Phe Arg Ile Thr Pro Ile Thr Ser Ile Ile Asn Arg Val Thr Lys Met 
                405                 410                 415     


Thr Gln Val Val Ile Asp Ala Glu Val Ile Gln Asn Lys Glu 
            420                 425                 430 


<210>  6
<211>  454
<212>  PRT
<213>  Clostridium perfringens

<400>  6

Met Lys Lys Val Asn Lys Ser Ile Ser Ile Phe Leu Ile Leu Tyr Leu 
1               5                   10                  15      


Ile Leu Thr Thr Ser Leu Thr Asn Pro Thr Tyr Ala Gln Asp Leu Gln 
            20                  25                  30          


Ala Tyr Ser Thr Asn Gln Ile Ala Lys Gly Ile Val Glu Arg Pro Glu 
        35                  40                  45              


Asp Phe Leu Lys Asp Lys Glu Lys Ala Lys Glu Trp Glu Lys Ser Glu 
    50                  55                  60                  


Ala Glu Arg Ile Glu Lys Lys Leu Glu Lys Ser Glu Ile Glu Ala Leu 
65                  70                  75                  80  


Glu Ser Tyr Lys Lys Asn Ser Leu Glu Ile Ser Lys Tyr Ser Gln Thr 
                85                  90                  95      


Arg Asn Tyr Phe Tyr Asp Tyr Gln Ile Glu Ala Asp Pro Arg Glu Lys 
            100                 105                 110         


Glu Tyr Lys Glu Leu Arg Asn Ala Ile Ser Lys Asn Lys Ile Asp Lys 
        115                 120                 125             


Ser Met Ser Val Tyr Tyr Phe Glu Ser Pro Glu Lys Phe Ala Phe Asn 
    130                 135                 140                 


Lys Asp Leu Arg Thr Ala Asn Gln Asn Glu Ile Ser Ser Glu Lys Phe 
145                 150                 155                 160 


Asn Glu Phe Lys Glu Thr Ile Gln Asp Lys Leu Phe Lys Gln Asp Gly 
                165                 170                 175     


Phe Lys Asp Ile Ser Leu Tyr Glu Pro Gly Lys Gly Asp Gln Lys Pro 
            180                 185                 190         


Thr Pro Leu Leu Ile His Leu Lys Leu Pro Arg Asn Thr Gly Met Leu 
        195                 200                 205             


Ser Tyr Lys Asn Ser Asn Asp Val Ser Thr Leu Ile Glu Gln Gly Tyr 
    210                 215                 220                 


Ser Ile Lys Ile Asp Lys Val Val Leu Ile Val Leu Glu Gly Lys Gln 
225                 230                 235                 240 


Tyr Ile Lys Ala Glu Ala Ser Ile Val Asn Ser Leu Asp Phe Lys Asp 
                245                 250                 255     


Asp Val Ser Lys Gly Asp Ser Trp Gly Lys Glu Asn Tyr Ser Asp Trp 
            260                 265                 270         


Ser Asn Lys Leu Thr Pro Asn Glu Leu Ala Asp Val Asn Asp Tyr Met 
        275                 280                 285             


Arg Gly Gly Tyr Thr Ala Ile Asn Asn Tyr Leu Ile Ser Asn Gly Pro 
    290                 295                 300                 


Val Asn Asn Pro Asn Pro Glu Leu Asp Ser Lys Val Asn Asn Ile Glu 
305                 310                 315                 320 


Asn Ala Leu Lys Arg Thr Pro Ile Pro Ser Asn Leu Ile Val Tyr Arg 
                325                 330                 335     


Arg Ser Gly Pro Gln Glu Phe Gly Leu Thr Leu Thr Ser Pro Glu Tyr 
            340                 345                 350         


Asp Phe Asn Lys Ile Glu Asn Ile Asp Ala Phe Lys Glu Lys Trp Glu 
        355                 360                 365             


Gly Lys Ile Ile Thr Tyr Pro Asn Phe Ile Ser Thr Ser Ile Gly Ser 
    370                 375                 380                 


Val Asn Met Ser Ala Phe Ala Lys Arg Lys Ile Ile Leu Arg Ile Asn 
385                 390                 395                 400 


Ile Pro Lys Gly Ser Pro Gly Ala Tyr Leu Ser Ala Ile Pro Gly Tyr 
                405                 410                 415     


Ala Gly Glu Tyr Glu Val Leu Leu Asn His Gly Ser Lys Phe Lys Ile 
            420                 425                 430         


Asn Lys Val Asp Ser Tyr Lys Asp Gly Thr Val Thr Lys Leu Ile Leu 
        435                 440                 445             


Asp Ala Thr Leu Ile Asn 
    450                 


<210>  7
<211>  463
<212>  PRT
<213>  Clostridium difficile

<400>  7

Met Lys Lys Phe Arg Lys His Lys Ser Ile Ser Asn Cys Ile Ser Ile 
1               5                   10                  15      


Leu Leu Ile Leu Tyr Leu Thr Leu Gly Ser Leu Leu Pro Asn Asn Ile 
            20                  25                  30          


Tyr Ala Gln Asp Leu Gln Ser Tyr Ser Glu Lys Val Cys Asn Thr Thr 
        35                  40                  45              


Tyr Lys Ala Pro Ile Glu Arg Pro Glu Asp Phe Leu Lys Asp Lys Glu 
    50                  55                  60                  


Arg Ala Lys Glu Trp Glu Arg Lys Glu Ala Glu Arg Ile Glu Gln Lys 
65                  70                  75                  80  


Leu Glu Arg Ser Glu Lys Glu Ala Leu Glu Ser Tyr Lys Lys Asp Ser 
                85                  90                  95      


Val Glu Ile Asn Lys Tyr Ser Gln Thr Arg Asn Tyr Phe Tyr Asp Tyr 
            100                 105                 110         


Gln Ile Glu Ala Asn Ser Arg Glu Lys Glu Tyr Arg Glu Leu Arg Asn 
        115                 120                 125             


Ala Ile Ser Lys Asn Lys Ile Asp Lys Pro Met Tyr Val Tyr Tyr Phe 
    130                 135                 140                 


Glu Ser Pro Glu Lys Phe Ala Phe Asn Lys Val Ile Arg Thr Glu Asn 
145                 150                 155                 160 


Gln Asn Glu Ile Ser Leu Glu Lys Phe Asn Glu Phe Lys Glu Thr Ile 
                165                 170                 175     


Gln Asn Lys Leu Phe Lys Gln Asp Gly Phe Lys Glu Ile Ser Leu Tyr 
            180                 185                 190         


Glu Pro Gly Lys Gly Asp Glu Glu Pro Thr Pro Leu Leu Met His Leu 
        195                 200                 205             


Lys Leu Pro Arg Asn Thr Gly Met Leu Pro Tyr Thr Asn Thr Asn Asn 
    210                 215                 220                 


Val Ser Thr Leu Ile Glu Gln Gly Tyr Ser Ile Lys Ile Asp Lys Ile 
225                 230                 235                 240 


Val Arg Ile Val Ile Asp Gly Lys His Tyr Ile Lys Ala Glu Ala Ser 
                245                 250                 255     


Val Val Ser Ser Leu Asp Phe Lys Asp Asp Val Ser Lys Gly Asp Ser 
            260                 265                 270         


Trp Gly Lys Ala Asn Tyr Asn Asp Trp Ser Asn Lys Leu Thr Pro Asn 
        275                 280                 285             


Glu Leu Ala Asp Val Asn Asp Tyr Met Arg Gly Gly Tyr Thr Ala Ile 
    290                 295                 300                 


Asn Asn Tyr Leu Ile Ser Asn Gly Pro Val Asn Asn Pro Asn Pro Glu 
305                 310                 315                 320 


Leu Asp Ser Lys Ile Thr Asn Ile Glu Asn Ala Leu Lys Arg Glu Pro 
                325                 330                 335     


Ile Pro Thr Asn Leu Thr Val Tyr Arg Arg Ser Gly Pro Gln Glu Phe 
            340                 345                 350         


Gly Leu Thr Leu Thr Ser Pro Glu Tyr Asp Phe Asn Lys Pro Glu Asn 
        355                 360                 365             


Ile Asp Ala Phe Lys Ser Lys Trp Glu Gly Gln Thr Leu Ser Tyr Pro 
    370                 375                 380                 


Asn Phe Ile Ser Thr Ser Ile Gly Ser Val Asn Met Ser Ala Phe Ala 
385                 390                 395                 400 


Lys Arg Lys Ile Val Leu Arg Ile Thr Ile Pro Lys Gly Ser Pro Gly 
                405                 410                 415     


Ala Tyr Leu Ser Ala Ile Pro Gly Tyr Ala Gly Glu Tyr Glu Val Leu 
            420                 425                 430         


Leu Asn His Gly Ser Lys Phe Lys Ile Ser Lys Ile Asp Ser Tyr Lys 
        435                 440                 445             


Asp Gly Ala Ile Thr Lys Leu Ile Val Asp Ala Thr Leu Ile Pro 
    450                 455                 460             


<210>  8
<211>  251
<212>  PRT
<213>  Bacillus cereus

<400>  8

Met Lys Ile Lys Lys Lys Phe Leu Pro Val Val Leu Ala Leu Ser Thr 
1               5                   10                  15      


Met Val Thr Gly Ser Thr Ala Phe Leu Thr Ser Thr Val His Ala Asn 
            20                  25                  30          


Thr Glu Ser Val Val Gln Lys Asn Ile Gln Lys Pro Leu Asp Phe Asn 
        35                  40                  45              


Ser Leu Ala Asn Lys Pro Leu Ala Asp Ala Trp Gly Glu Lys Phe Tyr 
    50                  55                  60                  


His Gln Trp Ile Pro Asn Val Ser Ser Thr Glu Ile Glu Glu Phe Lys 
65                  70                  75                  80  


Ser Tyr Met Glu Thr Gly Tyr His His Leu Asn Thr Tyr Leu Leu Glu 
                85                  90                  95      


Asn Lys Gly Gln Leu Thr Gly Lys Asp Ile Lys Met Glu Gln Lys Ile 
            100                 105                 110         


Lys His Leu Asp Arg Ala Phe Ser Ser Ser Ser Val Pro Asp Asp Ile 
        115                 120                 125             


Val Val Tyr Arg Arg Ser Lys Glu Ser Ser Phe Gly Leu Thr Glu Gly 
    130                 135                 140                 


Thr Leu Ile Lys Asp Asn Lys Ile Asn Glu Gln Glu Phe Ser Glu Phe 
145                 150                 155                 160 


Lys Asn Lys Leu Leu Gly Lys Tyr Lys Thr Asp Tyr Thr Tyr Met Ser 
                165                 170                 175     


Thr Ser Ile Leu Lys Asp Pro Ser Glu Ser Phe Asn Gly Arg Pro Ile 
            180                 185                 190         


Leu Ile Arg Leu Thr Val Pro Lys Gly Ser His Gly Ala Tyr Ile Ala 
        195                 200                 205             


Pro Leu Ser Ala Tyr Pro Trp Glu Met Glu Met Leu Leu Pro Arg Asn 
    210                 215                 220                 


Thr Thr Tyr Lys Val Asn Asp Ile Ser Tyr Val Lys Asn Gly Asn Ser 
225                 230                 235                 240 


Asn Tyr Val Leu Val Asp Ala Thr Ile Gln Lys 
                245                 250     


<210>  9
<211>  459
<212>  PRT
<213>  Clostridium spiroforme

<400>  9

Met Lys Lys Tyr Lys Asn Asn Cys Ile Ser Ile Leu Leu Met Leu Phe 
1               5                   10                  15      


Leu Ile Leu Thr Gly Leu Phe Pro Asn Thr Val Phe Ala Gln Gly Ala 
            20                  25                  30          


Gln Ser Tyr Asp Phe Arg Thr Ile Asn Asn Ile Ala Asn Tyr Ser Ala 
        35                  40                  45              


Ile Glu Arg Pro Glu Asp Phe Leu Lys Asp Lys Glu Lys Ala Lys Asp 
    50                  55                  60                  


Trp Glu Arg Lys Glu Ala Glu Arg Ile Glu Lys Asn Leu Glu Lys Ser 
65                  70                  75                  80  


Glu Arg Glu Ala Leu Glu Ser Tyr Lys Lys Asp Ala Val Glu Ile Ser 
                85                  90                  95      


Lys Tyr Ser Gln Val Arg Asn Tyr Phe Tyr Asp Tyr Pro Ile Glu Ala 
            100                 105                 110         


Asn Thr Arg Glu Lys Glu Tyr Lys Glu Leu Lys Asn Ala Val Ser Lys 
        115                 120                 125             


Asn Lys Ile Asp Lys Pro Met Tyr Val Tyr Tyr Phe Glu Ser Pro Glu 
    130                 135                 140                 


Lys Phe Ala Phe Asn Lys Glu Ile Arg Ala Glu Ser Gln Asn Glu Ile 
145                 150                 155                 160 


Ser Leu Glu Arg Phe Asn Glu Phe Lys Ala Thr Ile Gln Asp Lys Leu 
                165                 170                 175     


Phe Lys Gln Asp Gly Phe Lys Asp Ile Ser Leu Tyr Glu Pro Gly Asn 
            180                 185                 190         


Gly Asp Lys Lys Ser Thr Pro Leu Leu Ile His Leu Lys Leu Pro Lys 
        195                 200                 205             


Asp Thr Gly Met Leu Pro Tyr Ser Asn Ser Asn Asp Val Ser Thr Leu 
    210                 215                 220                 


Ile Glu Gln Gly Tyr Ser Ile Lys Ile Asp Lys Ile Val Arg Ile Val 
225                 230                 235                 240 


Leu Glu Gly Lys Gln Tyr Ile Lys Ala Glu Ala Ser Val Val Ser Cys 
                245                 250                 255     


Leu Asp Phe Lys Asp Asp Val Ser Lys Gly Asp Ser Trp Gly Lys Ala 
            260                 265                 270         


Asn Tyr Ser Asp Trp Ser Asn Lys Leu Ser Ser Asp Glu Leu Ala Gly 
        275                 280                 285             


Val Asn Asp Tyr Met Arg Gly Arg Tyr Thr Ala Ile Asn Asn Tyr Leu 
    290                 295                 300                 


Ile Ala Asn Gly Pro Thr Asn Asn Pro Asn Ala Glu Leu Asp Ala Lys 
305                 310                 315                 320 


Ile Asn Asn Ile Glu Asn Ala Leu Lys Arg Glu Pro Ile Pro Ala Asn 
                325                 330                 335     


Leu Val Val Tyr Arg Arg Ser Gly Pro Gln Glu Phe Gly Leu Thr Leu 
            340                 345                 350         


Ser Ser Pro Glu Tyr Asp Phe Asn Lys Val Glu Asn Ile Asp Ala Phe 
        355                 360                 365             


Lys Glu Lys Trp Glu Gly Gln Thr Leu Ser Tyr Pro Asn Phe Val Ser 
    370                 375                 380                 


Thr Ser Ile Gly Ser Val Asn Met Ser Ala Phe Ala Lys Arg Lys Ile 
385                 390                 395                 400 


Val Leu Arg Ile Ser Ile Pro Lys Asn Ser Pro Gly Ala Tyr Leu Ser 
                405                 410                 415     


Ala Ile Pro Gly Tyr Ala Gly Glu Tyr Glu Val Leu Leu Asn His Gly 
            420                 425                 430         


Ser Lys Phe Lys Ile Ser Lys Ile Asp Ser Tyr Lys Asp Gly Thr Thr 
        435                 440                 445             


Thr Lys Leu Ile Val Asp Arg Thr Leu Ile Asp 
    450                 455                 


<210>  10
<211>  374
<212>  PRT
<213>  Salmonella enterica

<400>  10

Met Leu Ile Leu Asn Gly Phe Ser Ser Ala Thr Leu Ala Leu Ile Thr 
1               5                   10                  15      


Pro Pro Phe Leu Pro Lys Gly Gly Lys Ala Leu Ser Gln Ser Gly Pro 
            20                  25                  30          


Asp Gly Leu Ala Ser Ile Thr Leu Pro Leu Pro Ile Ser Ala Glu Arg 
        35                  40                  45              


Gly Phe Ala Pro Ala Leu Ala Leu His Tyr Ser Ser Gly Gly Gly Asn 
    50                  55                  60                  


Gly Pro Phe Gly Val Gly Trp Ser Cys Ala Thr Met Ser Ile Ala Arg 
65                  70                  75                  80  


Arg Thr Ser His Gly Val Pro Gln Tyr Asn Asp Ser Asp Glu Phe Leu 
                85                  90                  95      


Gly Pro Asp Gly Glu Val Leu Val Gln Thr Leu Ser Thr Gly Asp Ala 
            100                 105                 110         


Pro Asn Pro Val Thr Cys Phe Ala Tyr Gly Asp Val Ser Phe Pro Gln 
        115                 120                 125             


Ser Tyr Thr Val Thr Arg Tyr Gln Pro Arg Thr Glu Ser Ser Phe Tyr 
    130                 135                 140                 


Arg Leu Glu Tyr Trp Val Gly Asn Ser Asn Gly Asp Asp Phe Trp Leu 
145                 150                 155                 160 


Leu His Asp Ser Asn Gly Ile Leu His Leu Leu Gly Lys Thr Ala Ala 
                165                 170                 175     


Ala Arg Leu Ser Asp Pro Gln Ala Ala Ser His Thr Ala Gln Trp Leu 
            180                 185                 190         


Val Glu Glu Ser Val Thr Pro Ala Gly Glu His Ile Tyr Tyr Ser Tyr 
        195                 200                 205             


Leu Ala Glu Asn Gly Asp Asn Val Asp Leu Asn Gly Asn Glu Ala Gly 
    210                 215                 220                 


Arg Asp Arg Ser Ala Met Arg Tyr Leu Ser Lys Val Gln Tyr Gly Asn 
225                 230                 235                 240 


Ala Thr Pro Ala Ala Asp Leu Tyr Leu Trp Thr Ser Ala Thr Pro Ala 
                245                 250                 255     


Val Gln Trp Leu Phe Thr Leu Val Phe Asp Tyr Gly Glu Arg Gly Val 
            260                 265                 270         


Asp Pro Gln Val Pro Pro Ala Phe Thr Ala Gln Asn Ser Trp Leu Ala 
        275                 280                 285             


Arg Gln Asp Pro Phe Ser Leu Tyr Asn Tyr Gly Phe Glu Ile Arg Leu 
    290                 295                 300                 


His Arg Leu Cys Arg Gln Val Leu Met Phe His His Phe Pro Asp Glu 
305                 310                 315                 320 


Leu Gly Glu Ala Asp Thr Leu Val Ser Arg Leu Leu Leu Glu Tyr Asp 
                325                 330                 335     


Glu Asn Pro Ile Leu Thr Gln Leu Cys Ala Ala Arg Thr Leu Ala Tyr 
            340                 345                 350         


Glu Gly Asp Gly Tyr Arg Arg Ala Pro Val Asn Asn Met Met Pro Pro 
        355                 360                 365             


Pro Pro Pro Pro Pro Met 
    370                 


<210>  11
<211>  163
<212>  PRT
<213>  Aeromonas salmonicida

<400>  11

Val Ser Pro Glu Asp Leu Gln Arg Leu Met Lys Gln Ala Ala Phe Gly 
1               5                   10                  15      


Ser Ser Leu Gly Gly Phe Ala Lys Ala Asp Val Leu Asn Asn Ile Thr 
            20                  25                  30          


Gly Glu Gln Leu Gly Lys Asp His Ala Ser Leu Ala Thr Gly Asn Gly 
        35                  40                  45              


Pro Leu Arg Ser Leu Cys Thr Ala Leu Gln Ala Val Val Ile Gly Ser 
    50                  55                  60                  


Gln Gln Pro Gln Leu Arg Glu Leu Ala Thr Gly Leu Leu Ala Arg Pro 
65                  70                  75                  80  


Ile Ala Gly Ile Pro Leu Gln Gln Trp Gly Ser Val Gly Gly Lys Val 
                85                  90                  95      


Thr Glu Leu Leu Thr Ser Ala Pro Pro Glu Leu Leu Lys Glu Ala Met 
            100                 105                 110         


Ser Gln Leu His Thr Ala Met Gly Glu Val Ala Asp Leu Gln Arg Ala 
        115                 120                 125             


Val Lys Ala Glu Val Ala Gly Glu Pro Ala Arg Ser Ala Thr Thr Ala 
    130                 135                 140                 


Ala Ala Val Ala Pro Leu Gln Ser Gly Glu Ser Glu Val Asn Val Glu 
145                 150                 155                 160 


Pro Ala Asp 
            


<210>  12
<211>  716
<212>  PRT
<213>  Aeromonas hydrophila

<400>  12

Met Ala Asp Ser Thr Gly Leu Gln Phe Thr Val Lys Val Gly Ala Leu 
1               5                   10                  15      


Pro Glu Ser Thr Phe Val Val Ala Glu Phe Ala Leu Asp Glu Gly Leu 
            20                  25                  30          


Asn Arg Pro Phe Asn Leu Arg Leu Glu Leu Ala Ser Ala Gln Pro Asp 
        35                  40                  45              


Leu Asp Phe Gly Ala Val Leu Asp Gln Pro Cys Glu Leu Leu Val Trp 
    50                  55                  60                  


Tyr Asn Gly Glu Leu Gln Arg Arg Val Cys Gly Val Val Ser Asp Phe 
65                  70                  75                  80  


Ala Gln Gly Asp Ser Gly Phe Arg Arg Thr Arg Tyr Gln Leu Leu Val 
                85                  90                  95      


Gln Pro Ala Leu Trp Arg Leu Ser Leu Arg Gln Asn Ser Arg Ile Phe 
            100                 105                 110         


Gln Ala Gln Lys Pro Asp Glu Ile Leu Ser Ile Leu Leu Gln Glu His 
        115                 120                 125             


Gly Ile Thr Asp Tyr Ala Phe Ala Leu Lys Asn Glu His Ala Lys Arg 
    130                 135                 140                 


Glu Tyr Cys Val Gln Tyr Arg Glu Thr Asp Leu Asp Phe Val Asn Arg 
145                 150                 155                 160 


Leu Ala Ala Glu Glu Gly Met Phe Tyr Phe His Glu Phe Glu Ala Gly 
                165                 170                 175     


Lys His Arg Ile Val Phe Ala Asp Asp Ala Ala Ala Leu Thr Ala Gly 
            180                 185                 190         


Pro Glu Leu Phe Phe Asn Leu Gly Asn Arg Ser Leu Glu Gln Gly Pro 
        195                 200                 205             


Tyr Val Arg Gln Phe His Tyr Arg Glu Ala Val Arg Pro Ser Asp Val 
    210                 215                 220                 


Glu Leu Lys Asp Tyr Ser Phe Lys Thr Pro Ala Tyr Gly Leu Ser Arg 
225                 230                 235                 240 


Lys Lys Val Gly Val Glu Leu Thr His Gln Arg Asp Thr Tyr Gln His 
                245                 250                 255     


Phe Asp Phe Pro Gly Arg Tyr Lys Glu Asp Pro Thr Gly Lys Ala Phe 
            260                 265                 270         


Ala Gln His Arg Leu Asp Ala Leu Arg Asn Asp Ala Val Ala Gly Ser 
        275                 280                 285             


Gly Lys Ser Asn Ser Ala Ala Leu Leu Pro Gly Gln Thr Phe Ser Leu 
    290                 295                 300                 


Thr Glu His Pro Asn Gly Ser Leu Asn Thr Asp Trp Gln Val Val His 
305                 310                 315                 320 


Ile Arg His Thr Gly Leu Gln Pro Gln Ala Leu Glu Glu Glu Gly Gly 
                325                 330                 335     


Ser Gly Pro Thr Val Tyr His Asn Glu Phe Ser Val Val Lys Ala Ser 
            340                 345                 350         


Thr Thr Trp Arg Ala Arg Ile Gly Ser Pro Glu Ala Pro His Lys Pro 
        355                 360                 365             


Met Val Asp Gly Pro Gln Ile Val Thr Val Val Gly Pro Asp Gly Glu 
    370                 375                 380                 


Glu Ile Tyr Cys Asp Glu His Gly Arg Val Lys Leu Gln Phe Pro Trp 
385                 390                 395                 400 


Asp Arg Tyr Gly Ser Ser Asn Asp Gln Ser Ser Cys Trp Val Arg Val 
                405                 410                 415     


Ser Gln Gly Trp Ala Gly Gly Gln Tyr Gly Met Met Ala Ile Pro Arg 
            420                 425                 430         


Ile Gly His Glu Val Ile Val Ser Phe Leu Glu Gly Asp Pro Asp Gln 
        435                 440                 445             


Pro Ile Ile Thr Gly Arg Thr Phe His Ala Thr Asn Arg Pro Pro Tyr 
    450                 455                 460                 


Glu Leu Pro Ala Asn Lys Thr Arg Thr Val Leu Arg Thr Glu Thr His 
465                 470                 475                 480 


Gln Gly Glu Gly Phe Asn Glu Leu Arg Phe Glu Asp Gln Ala Gly Lys 
                485                 490                 495     


Glu Glu Ile Tyr Ile His Gly Gln Lys Asp Leu Asn Val Leu Ile Glu 
            500                 505                 510         


Asn Asp Ala Ala Trp His Ile Lys His Asp Glu His Arg Asp Ile Asp 
        515                 520                 525             


Asn Glu Arg Val Thr Arg Ile Lys Ala Asn Asp His Leu Thr Val Glu 
    530                 535                 540                 


Gly Glu Lys Arg Asp Gln Ile Lys Ala Asp Tyr Ser Leu Thr Val Asp 
545                 550                 555                 560 


Ala Ser Leu His Gln Lys Leu Gly Gln Ser Leu Leu Met Glu Ala Gly 
                565                 570                 575     


Ser Glu Val His His Lys Ala Gly Met Lys Ile Val Met Glu Ala Gly 
            580                 585                 590         


Ala Glu Leu Thr Leu Lys Val Gly Gly Ser Phe Val Lys Leu Asp Ala 
        595                 600                 605             


Ser Gly Val Thr Leu Ser Gly Gly Ser Ile Lys Met Asn Ser Gly Gly 
    610                 615                 620                 


Ser Pro Gly Ser Gly Ser Gly Trp Gly Gly Lys Ala Pro Ile Gln Pro 
625                 630                 635                 640 


Gly Asn Val Glu Val Pro Thr Pro Pro Pro Ala Thr Leu Pro Ala Pro 
                645                 650                 655     


Ala Ile His Lys Ser Met Glu Ser Met Ala Pro Leu Ala Lys Pro Cys 
            660                 665                 670         


Pro Ala Ala Pro Pro Pro Val Pro Pro Pro Pro Ala Gly Gly Pro Pro 
        675                 680                 685             


Ala Pro Pro Pro Ala Pro Pro Gln Leu Ala Gly Gly Pro Met Met Pro 
    690                 695                 700                 


Pro Pro Pro Pro Pro Val Ala Ala Thr Gly Glu Gly 
705                 710                 715     


