                         SEQUENCE LISTING

<110>  F. Hoffmann-La Roche AG
 
<120>  Method for reduction of 1->2 reading frame shifts

<130>  30888 WO

<150>  EP 12157512.0
<151>  2012-02-29

<150>  EP 12162810.1
<151>  2012-04-02

<160>  56    

<170>  PatentIn version 3.5

<210>  1
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AR dipeptide encoding oligonucleotide 1

<400>  1
gcgagg                                                                   6


<210>  2
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  QKK tripeptide encoding oligonucleotide 2

<400>  2
gcgaga                                                                   6


<210>  3
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AR dipeptide encoding oligonucleotide 3

<400>  3
gcacgt                                                                   6


<210>  4
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AR dipeptide encoding oligonucleotide 4

<400>  4
gcgcgt                                                                   6


<210>  5
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AR dipeptide encoding oligonucleotide 5

<400>  5
gcccgt                                                                   6


<210>  6
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  QKK tripeptide

<400>  6

Ala Arg 
1       


<210>  7
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln 
            260                 265         


<210>  8
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  8

Ser Leu Lys Gly Ser 
1               5   


<210>  9
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tetranectin-apolipoprotein A-I fusion polypeptide comprising 
       expression and purification tags

<400>  9

Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser His His His His His 
1               5                   10                  15      


His Gly Ser Val Val Ala Pro Pro Ala Pro Ile Val Asn Ala Lys Lys 
            20                  25                  30          


Asp Val Val Asn Thr Lys Met Phe Glu Glu Leu Lys Ser Arg Leu Asp 
        35                  40                  45              


Thr Leu Ala Gln Glu Val Ala Leu Leu Lys Glu Gln Gln Ala Leu Gln 
    50                  55                  60                  


Thr Val Asp Glu Pro Pro Gln Ser Pro Trp Asp Arg Val Lys Asp Leu 
65                  70                  75                  80  


Ala Thr Val Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val 
                85                  90                  95      


Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu 
            100                 105                 110         


Leu Asp Asn Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu 
        115                 120                 125             


Gln Leu Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu 
    130                 135                 140                 


Thr Glu Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys 
145                 150                 155                 160 


Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu 
                165                 170                 175     


Glu Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu 
            180                 185                 190         


Gln Glu Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser 
        195                 200                 205             


Pro Leu Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala 
    210                 215                 220                 


Leu Arg Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu 
225                 230                 235                 240 


Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala 
                245                 250                 255     


Glu Tyr His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys 
            260                 265                 270         


Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu 
        275                 280                 285             


Glu Ser Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys 
    290                 295                 300                 


Lys Leu Asn Thr Gln 
305                 


<210>  10
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tetranectin-apolipoprotein A-I fusion polypeptide (IVN)

<400>  10

Ile Val Asn Ala Lys Lys Asp Val Val Asn Thr Lys Met Phe Glu Glu 
1               5                   10                  15      


Leu Lys Ser Arg Leu Asp Thr Leu Ala Gln Glu Val Ala Leu Leu Lys 
            20                  25                  30          


Glu Gln Gln Ala Leu Gln Thr Val Asp Glu Pro Pro Gln Ser Pro Trp 
        35                  40                  45              


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
    50                  55                  60                  


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
65                  70                  75                  80  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
                85                  90                  95      


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
            100                 105                 110         


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
        115                 120                 125             


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
    130                 135                 140                 


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
145                 150                 155                 160 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
                165                 170                 175     


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
            180                 185                 190         


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
        195                 200                 205             


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
    210                 215                 220                 


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
225                 230                 235                 240 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
                245                 250                 255     


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
            260                 265                 270         


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln 
        275                 280             


<210>  11
<211>  284
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tetranectin-apolipoprotein A-I fusion polypeptide (PIVN)

<400>  11

Pro Ile Val Asn Ala Lys Lys Asp Val Val Asn Thr Lys Met Phe Glu 
1               5                   10                  15      


Glu Leu Lys Ser Arg Leu Asp Thr Leu Ala Gln Glu Val Ala Leu Leu 
            20                  25                  30          


Lys Glu Gln Gln Ala Leu Gln Thr Val Asp Glu Pro Pro Gln Ser Pro 
        35                  40                  45              


Trp Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys 
    50                  55                  60                  


Asp Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly 
65                  70                  75                  80  


Lys Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser 
                85                  90                  95      


Thr Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe 
            100                 105                 110         


Trp Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser 
        115                 120                 125             


Lys Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp 
    130                 135                 140                 


Phe Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val 
145                 150                 155                 160 


Glu Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His 
                165                 170                 175     


Glu Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg 
            180                 185                 190         


Ala Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser 
        195                 200                 205             


Asp Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu 
    210                 215                 220                 


Asn Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His 
225                 230                 235                 240 


Leu Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg 
                245                 250                 255     


Gln Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser 
            260                 265                 270         


Ala Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln 
        275                 280                 


<210>  12
<211>  285
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tetranectin-apolipoprotein A-I (XPIVN)


<220>
<221>  MISC_FEATURE
<223>  X = G or S or T

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  12

Xaa Pro Ile Val Asn Ala Lys Lys Asp Val Val Asn Thr Lys Met Phe 
1               5                   10                  15      


Glu Glu Leu Lys Ser Arg Leu Asp Thr Leu Ala Gln Glu Val Ala Leu 
            20                  25                  30          


Leu Lys Glu Gln Gln Ala Leu Gln Thr Val Asp Glu Pro Pro Gln Ser 
        35                  40                  45              


Pro Trp Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu 
    50                  55                  60                  


Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu 
65                  70                  75                  80  


Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr 
                85                  90                  95      


Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu 
            100                 105                 110         


Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met 
        115                 120                 125             


Ser Lys Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp 
    130                 135                 140                 


Asp Phe Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys 
145                 150                 155                 160 


Val Glu Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu 
                165                 170                 175     


His Glu Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp 
            180                 185                 190         


Arg Ala Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr 
        195                 200                 205             


Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys 
    210                 215                 220                 


Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu 
225                 230                 235                 240 


His Leu Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu 
                245                 250                 255     


Arg Gln Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu 
            260                 265                 270         


Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln 
        275                 280                 285 


<210>  13
<211>  285
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tetranectin-apolipoprotein A-I fusion polypeptide (APIVN)

<400>  13

Ala Pro Ile Val Asn Ala Lys Lys Asp Val Val Asn Thr Lys Met Phe 
1               5                   10                  15      


Glu Glu Leu Lys Ser Arg Leu Asp Thr Leu Ala Gln Glu Val Ala Leu 
            20                  25                  30          


Leu Lys Glu Gln Gln Ala Leu Gln Thr Val Asp Glu Pro Pro Gln Ser 
        35                  40                  45              


Pro Trp Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu 
    50                  55                  60                  


Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu 
65                  70                  75                  80  


Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr 
                85                  90                  95      


Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu 
            100                 105                 110         


Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met 
        115                 120                 125             


Ser Lys Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp 
    130                 135                 140                 


Asp Phe Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys 
145                 150                 155                 160 


Val Glu Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu 
                165                 170                 175     


His Glu Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp 
            180                 185                 190         


Arg Ala Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr 
        195                 200                 205             


Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys 
    210                 215                 220                 


Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu 
225                 230                 235                 240 


His Leu Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu 
                245                 250                 255     


Arg Gln Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu 
            260                 265                 270         


Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln 
        275                 280                 285 


<210>  14
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tetranectin-apolipoprotein A-I fusion polypeptide (XIVN) with 
       hexa-histidine-tag


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X = any one of AP, GP, SP, PP, GSAP, GSGP, GSSP, GSPP, GGGS, 
       GGGGS, GGGSGGGS, GGGGSGGGGS, GGGSGGGSGGGS, GGGGSGGGGSGGGGS, 
       GGGSAP, GGGSGP, GGGSSP

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X = any one of GGGSPP,  GGGGSAP, GGGGSGP, GGGGSSP, GGGGSPP,  
       GGGSGGGSAP, GGGSGGGSGP, GGGSGGGSSP, GGGSGGGSPP,  GGGSGGGSGGGSAP, 
       GGGSGGGSGGGSGP, GGGSGGGSGGGSSP, GGGSGGGSGGGSPP

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X = any one of GGGGSAP, GGGGSGP, GGGGSSP, GGGGSPP, GGGGSGGGGSAP, 
       GGGGSGGGGSGP, GGGGSGGGGSSP, GGGGSGGGGSPP, GGGGSGGGGSGGGGSAP, 
       GGGGSGGGGSGGGGSGP, GGGGSGGGGSGGGGSSP, and GGGGSGGGGSGGGGSPP.

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  14

His His His His His His Xaa Ile Val Asn Ala Lys Lys Asp Val Val 
1               5                   10                  15      


Asn Thr Lys Met Phe Glu Glu Leu Lys Ser Arg Leu Asp Thr Leu Ala 
            20                  25                  30          


Gln Glu Val Ala Leu Leu Lys Glu Gln Gln Ala Leu Gln Thr Val Asp 
        35                  40                  45              


Glu Pro Pro Gln Ser Pro Trp Asp Arg Val Lys Asp Leu Ala Thr Val 
    50                  55                  60                  


Tyr Val Asp Val Leu Lys Asp Ser Gly Arg Asp Tyr Val Ser Gln Phe 
65                  70                  75                  80  


Glu Gly Ser Ala Leu Gly Lys Gln Leu Asn Leu Lys Leu Leu Asp Asn 
                85                  90                  95      


Trp Asp Ser Val Thr Ser Thr Phe Ser Lys Leu Arg Glu Gln Leu Gly 
            100                 105                 110         


Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr Glu Gly 
        115                 120                 125             


Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala Lys Val 
    130                 135                 140                 


Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu Met Glu 
145                 150                 155                 160 


Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln Glu Gly 
                165                 170                 175     


Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro Leu Gly 
            180                 185                 190         


Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu Arg Thr 
        195                 200                 205             


His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala Ala Arg 
    210                 215                 220                 


Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu Tyr His 
225                 230                 235                 240 


Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala Lys Pro 
                245                 250                 255     


Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu Ser Phe 
            260                 265                 270         


Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys Leu Asn 
        275                 280                 285             


Thr Gln 
    290 


<210>  15
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  15

Gly Ser Ala Pro 
1               


<210>  16
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker 2

<400>  16

Gly Ser Gly Pro 
1               


<210>  17
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 3

<400>  17

Gly Ser Ser Pro 
1               


<210>  18
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 4

<400>  18

Gly Ser Pro Pro 
1               


<210>  19
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 5

<400>  19

Gly Gly Gly Ser 
1               


<210>  20
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 6

<400>  20

Gly Gly Gly Gly Ser 
1               5   


<210>  21
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 7

<400>  21

Gly Gly Gly Ser Gly Gly Gly Ser 
1               5               


<210>  22
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 8

<400>  22

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  23
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 9

<400>  23

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10          


<210>  24
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 10

<400>  24

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  25
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 11

<400>  25

Gly Gly Gly Ser Ala Pro 
1               5       


<210>  26
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 12

<400>  26

Gly Gly Gly Ser Gly Pro 
1               5       


<210>  27
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 13

<400>  27

Gly Gly Gly Ser Ser Pro 
1               5       


<210>  28
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 14

<400>  28

Gly Gly Gly Ser Pro Pro 
1               5       


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 15

<400>  29

Gly Gly Gly Gly Ser Ala Pro 
1               5           


<210>  30
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 16

<400>  30

Gly Gly Gly Gly Ser Gly Pro 
1               5           


<210>  31
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 17

<400>  31

Gly Gly Gly Gly Ser Ser Pro 
1               5           


<210>  32
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 18

<400>  32

Gly Gly Gly Gly Ser Pro Pro 
1               5           


<210>  33
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 19

<400>  33

Gly Gly Gly Ser Gly Gly Gly Ser Ala Pro 
1               5                   10  


<210>  34
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 20

<400>  34

Gly Gly Gly Ser Gly Gly Gly Ser Gly Pro 
1               5                   10  


<210>  35
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 21

<400>  35

Gly Gly Gly Ser Gly Gly Gly Ser Ser Pro 
1               5                   10  


<210>  36
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 22

<400>  36

Gly Gly Gly Ser Gly Gly Gly Ser Pro Pro 
1               5                   10  


<210>  37
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 23

<400>  37

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Ala Pro 
1               5                   10                  


<210>  38
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 24

<400>  38

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Pro 
1               5                   10                  


<210>  39
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 25

<400>  39

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Ser Pro 
1               5                   10                  


<210>  40
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 26

<400>  40

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Pro Pro 
1               5                   10                  


<210>  41
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 27

<400>  41

Gly Gly Gly Gly Ser Ala Pro 
1               5           


<210>  42
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 28

<400>  42

Gly Gly Gly Gly Ser Gly Pro 
1               5           


<210>  43
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 29

<400>  43

Gly Gly Gly Gly Ser Ser Pro 
1               5           


<210>  44
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 30

<400>  44

Gly Gly Gly Gly Ser Pro Pro 
1               5           


<210>  45
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 31

<400>  45

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro 
1               5                   10          


<210>  46
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 32

<400>  46

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Pro 
1               5                   10          


<210>  47
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 33

<400>  47

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Pro 
1               5                   10          


<210>  48
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 34

<400>  48

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro Pro 
1               5                   10          


<210>  49
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 35

<400>  49

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
1               5                   10                  15      


Pro 
    


<210>  50
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 36

<400>  50

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Pro 
    


<210>  51
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 37

<400>  51

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
1               5                   10                  15      


Pro 
    


<210>  52
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker 38

<400>  52

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro 
1               5                   10                  15      


Pro 
    


<210>  53
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal amino acid sequence of the shortened by-product

<400>  53

Val Ala Arg Arg Asn Gly Thr Val Gln Thr Glu Ser 
1               5                   10          


<210>  54
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human interferone fragment

<400>  54

Cys Asp Leu Pro Gln Thr His Ser Leu 
1               5                   


<210>  55
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hexa-histidine tag

<400>  55

His His His His His His 
1               5       


<210>  56
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgA protease cleavage site

<400>  56

Val Val Ala Pro Pro Ala Pro 
1               5           


