                         SEQUENCE LISTING

<110>  U3 Pharma AG
       
 
<120>  HER3 inhibitor for modulating radiosensitivity

<130>  53017P US

<140>  
<141>  

<150>  
<151>  

<160>  582   

<170>  PatentIn version 3.3

<210>  1
<211>  342
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  1
gaggtgcagc tggtggagtc tggaggaggc ttgatccagc ctggggggtc cctgagactc     60

tcctgtgcag cctctgggtt caccgtcagt agcaactaca tgagctgggt ccgccaggct    120

ccagggaagg ggctggattg ggtctcagtt atttatagcg gtggtagcac atactacgca    180

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac gctgtatctt    240

caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgcgag agggcagtgg    300

ctggacgtct ggggccaagg gaccacggtc accgtctcct ca                       342


<210>  2
<211>  114
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  2

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Asp Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Gln Trp Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  3
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  3
gatattgtga tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc     60

atctcctgca ggtcaagtca gagcctcctg catagtaatg gatacaacta tttggattgg    120

tacctgcaga ggccagggca gtctccacaa ctcctgttct atttgggttt tcatcgggcc    180

tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac actgaaaatc    240

agcagagtgg aggctgagga tgttggggtt tattactgca ggcaagctct acaaactccg    300

ctcactttcg gcggagggac caaggtggag atcaaa                              336


<210>  4
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  4

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Phe Tyr Leu Gly Phe His Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Arg Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  5
<211>  374
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  5
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc     60

acctgtactg tctctggtgg ctccatcagc agtggtggtt actactggag ctggatccgc    120

cagcacccag ggaagggcct ggagtggatt gggtacatct attccagtgg gagcacctac    180

tacaacccgt ccctcaagag tcgagttacc atatcagtag acacgtctaa gaaccagttc    240

tccctgaagc tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgagagat    300

agggaactgg aactttacta ctactactac ggtatggacg tctggggcca agggaccacg    360

gtcaccgtct cctc                                                      374


<210>  6
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  6

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Ser Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Arg Glu Leu Glu Leu Tyr Tyr Tyr Tyr Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 


<210>  7
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  7
gatattgtga tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc     60

atctcctgca ggtctagtca gagcctcctg tatagtaatg gatacaacta tttggattgg    120

tacctgcaga agccagggca gtctccacag ctcctgatct atttgggttc taatcgggcc    180

tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac actgaaaatc    240

agcagagtgg aggctgagga tgttgggatt tattactgca tgcaagctct acaaactccg    300

ctcactttcg gcggagggac caaggtggag atcaaa                              336


<210>  8
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  8

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  9
<211>  357
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  9
cagatcacct tgaaggagtc tggtcctacg ctggtgaaac ccacacagac cctcacgctg     60

acctgcacct tctctgggtt ctcactcagc actagtggag tgggtgtggg ctggatccgt    120

cagcccccag gaaaggccct ggactggctt gcactcattt attggaatga tgataagcgc    180

tacagcccat ctctgaagag caggctcacc atcaccaagg acacctccaa aaaccaggtg    240

gtccttacaa tgaccaacat ggatcttgtg gacacagcca catattactg tgtacacaga    300

gacgaagttc gagggtttga ctactggggc cagggaaccc tggtcaccgt ctcctca       357


<210>  10
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  10

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Asp 
        35                  40                  45              


Trp Leu Ala Leu Ile Tyr Trp Asn Asp Asp Lys Arg Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Leu Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Val His Arg Asp Glu Val Arg Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  11
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  11
gatgttgtga tgactcagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc     60

atctcctgca ggtctagtca aagcctcgta tacagtgatg gatacaccta cttgcattgg    120

tttcagcaga ggccaggcca atctccaagg cgccttattt ataaggtttc taactgggac    180

tctggggtcc cagacagatt cagcggcagt gggtcaggca ctgatttcac actgaaaatc    240

agcagggtgg aggctgagga tgttggggtt tattactgca tgcaaggtgc acactggccg    300

atcaccttcg gccaagggac acgactggag attaaa                              336


<210>  12
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  12

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 
            20                  25                  30          


Asp Gly Tyr Thr Tyr Leu His Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Trp Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Ala His Trp Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 110         


<210>  13
<211>  374
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  13
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc     60

acctgcactg tctctggtgg ctccatcagc agtggtgggt actactggag ctggatccgc    120

cagcacccag ggaagggcct ggagtggatt gggtacatct attacagtgg gagcacctac    180

tacaacccgt ccctcaagag tcgagttacc atatcagtag acacgtctaa gaaccagttc    240

tccctgaagc tgagctctgt gactgccgcg gacacggccg tgtatttctg tgcgagagat    300

cgggaacttg agggttactc caactactac ggtgtggacg tctggggcca agggaccacg    360

gtcaccgtct cctc                                                      374


<210>  14
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  14

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Arg Asp Arg Glu Leu Glu Gly Tyr Ser Asn Tyr Tyr Gly Val 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 


<210>  15
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  15
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc gggcaagtca ggccattagc aactatttaa attggtatca gcagaaacca    120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca    180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct    240

gaagattttg caacttatta ctgtcaacag aataatagtc tcccgatcac cttcggccaa    300

gggacacgac tggagattaa a                                              321


<210>  16
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  16

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ala Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Ser Leu Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  17
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  17
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc     60

tcctgtaagg gttctggata cagctttacc agctactgga tcggctgggt gcgccagatg    120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac    180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac    240

ctgcagtgga gcagcctgaa ggcctcggac accgccatgt attactgtgc gagacatgaa    300

aactacggtg actacaacta ctggggccag ggaaccctgg tcaccgtctc ctca          354


<210>  18
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  18

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Glu Asn Tyr Gly Asp Tyr Asn Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  19
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  19
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtcggaga cagagtcacc     60

atcacttgcc gggcaagtca gagcattcgc agctatttaa attggtatca gcagaaacca    120

gggaaagccc ctaagctcct gatctatgct gcttccagtt tgcaaagtgg ggtcccatca    180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct    240

gaagattttg cactttactg ctgtcaacag agtaacggtt ccccgctcac tttcggcgga    300

gggaccaagg tggagatcaa a                                              321


<210>  20
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  20

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Arg Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Leu Tyr Cys Cys Gln Gln Ser Asn Gly Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  21
<211>  380
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  21
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc     60

acctgcactg tctctggtgg ctccatcagc agtggtggtt actactggag ctggatccgc    120

cagcacccag ggaagggcct ggagtggatt gggtacatct attacagtgg gagcacctac    180

tacaacccgt ccctcaggag tcgagttacc atatcagtag acacgtctaa gaaccagttc    240

tccctgaagc tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgagagat    300

agagagagag agtgggatga ttacggtgac ccccaaggta tggacgtctg gggccaaggg    360

accacggtca ccgtctcctc                                                380


<210>  22
<211>  126
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  22

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Arg Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Arg Glu Arg Glu Trp Asp Asp Tyr Gly Asp Pro Gln 
            100                 105                 110         


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125     


<210>  23
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  23
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc gggcaagtca gagcattagc agctatttac attggtatca gcagaaacca    120

gggaaagccc ctaagctcct gatccatgct gcatccagtt tacaaagtgg ggtcccatca    180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagtag tctgcaacct    240

gaagattttg caacttacta ctgtcaacag agttacagta acccgctcac tttcggcgga    300

gggaccaagg tggagatcca a                                              321


<210>  24
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  24

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Asn Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Gln 
            100                 105         


<210>  25
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  25
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc     60

tcctgtaagg gttctggata cagctttacc agctactgga tcggctgggt gcgccagatg    120

cccgggaaag gcctggagtg gatggggatc atctggcctg gtgactctga taccatatac    180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac    240

ctgcagtgga gcagcctgaa ggcctcggac accgccatgt attactgtgc gagacatgaa    300

aactacggtg actacaacta ctggggccag ggaaccctgg tcaccgtctc ctca          354


<210>  26
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  26

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Trp Pro Gly Asp Ser Asp Thr Ile Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Glu Asn Tyr Gly Asp Tyr Asn Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  27
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  27
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtgggaga cagagtcacc     60

atcacttgcc gggcaagtca gagcattcga agttatttaa attggtatca gcagaaaccg    120

gggaatgccc ctaaactcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca    180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct    240

gaagattttg cactttacta ctgtcaacag agtatcagtt ccccgctcac tttcggcgga    300

gggaccaagg tggagatcaa a                                              321


<210>  28
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  28

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Arg Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln Ser Ile Ser Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  29
<211>  374
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  29
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc     60

tcctgcaagg cttctggata caccttcacc agttatgata tcaactgggt gcgacaggcc    120

actggacaag ggcttgagtg gatgggatgg atgaacccta acagtggtga cactggctat    180

gcacaggtgt tccagggcag agtcaccatg acctggaaca cctccataag cacagcctac    240

atggaactga gcagcctgag atctgaggac acggccgtgt attactgtgc gagatttggg    300

gatctcccgt atgactacag ttactacgaa tggttcgacc cctggggcca gggaaccctg    360

gtcaccgtct cctc                                                      374


<210>  30
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  30

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Asn Ser Gly Asp Thr Gly Tyr Ala Gln Val Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Trp Asn Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Gly Asp Leu Pro Tyr Asp Tyr Ser Tyr Tyr Glu Trp Phe 
            100                 105                 110         


Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 


<210>  31
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  31
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc gggcaagcca gagcattagc agctatttaa attggtatca gcagagacca    120

gggaaagccc ctaagctcct gatctatgca gcatccagtt tgcaaagtgg ggtcccatca    180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct    240

gaagattttg caacttacta ctgtcaacag agttacagta ccccgctcac tttcggcgga    300

gggaccaagg tggagatcaa a                                              321


<210>  32
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  32

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  33
<211>  386
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  33
caggtacagc tgcagcagtc aggtccagga ctggtgaagc cctcgcagac cctctcactc     60

acctgtgcca tctccgggga cagtgtctct agcaacagtg ctgcttggaa ctggatcagg    120

cagtccccat cgagaggcct tgagtggctg ggaaggacat actacaggtc caagtggtat    180

aatgattatg cagtatctgt gaaaagtcga ataaccatca acccagacac atccaagaac    240

cagttctccc tgcagctgaa ctctgtgact cccgaggaca cggctgtgta ttactgtgca    300

agagatctct acgatttttg gagtggttat ccctactact acggtatgga cgtctggggc    360

caagggacca cggtcaccgt ctcctc                                         386


<210>  34
<211>  128
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  34

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Asp Leu Tyr Asp Phe Trp Ser Gly Tyr Pro Tyr 
            100                 105                 110         


Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


<210>  35
<211>  383
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  35
caggtacagc tgcagcagtc aggtccagga ctggtgaagc cctcgcagac cctctcactc     60

acctgtgcca tctccgggga cagtgtctct agcaacagtg ctgcttggaa ctggatcagg    120

cagtccccat cgagaggcct tgagtggctg ggaaggacat actacaggtc caagtggtat    180

aatgattatg cagtatctgt gaaaagtcga ataaccatca acccagacac atccaagaac    240

cagttctccc tgcagctgaa ctctgtgact cccgaggaca cggctgtgta ttactgtgca    300

agagattact atggttcggg gagtttctac tactactacg gtatggacgt ctggggccaa    360

gggaccacgg tcaccgtctc ctc                                            383


<210>  36
<211>  127
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  36

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Asp Tyr Tyr Gly Ser Gly Ser Phe Tyr Tyr Tyr 
            100                 105                 110         


Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125         


<210>  37
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  37
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca    120

gggaaagccc ctaaggtcct gatctatgct gcatccaatt tgcaaagtgg ggtcccatca    180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct    240

gaagattttg caacttacta ctgtcaacag agttacagta cccctcggac gttcggccaa    300

gggaccaagg tggaaatcaa a                                              321


<210>  38
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  38

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  39
<211>  371
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  39
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc     60

acctgcactg tctctggtgg ctccatcagt agttactact ggagctggat ccggcagccc    120

gccgggaagg gactggagtg gattgggcat atctatacca gtgggagcac caactacaac    180

ccctccctca agagtcgagt caccatgtca gtagacacgt ccaagaacca gttctccctg    240

aagctgagct ctgtgaccgc cgcggacacg gccgtgtatt actgtgcgag agaagcgatt    300

tttggagtgg gcccctacta ctactacggt atggacgtct ggggccaagg gaccacggtc    360

accgtctcct c                                                         371


<210>  40
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  40

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly His Ile Tyr Thr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Ala Ile Phe Gly Val Gly Pro Tyr Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120             


<210>  41
<211>  377
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  41
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc     60

tcctgcaagg cttctggata caccttcacc ggctactata tgcactgggt gcgacaggcc    120

cctggacaag ggcttgagtg gatgggatgg atcaacccta atattggtgg cacaaactgt    180

gcacagaagt ttcagggcag ggtcaccatg accagggaca cgtccatcag cacagcctac    240

atggagctga gcaggctgag atctgacgac acggccgtgt attactgtgc gagaggggga    300

cggtatagca gcagctggtc ctactactac tacggtatgg acgtctgggg ccaagggacc    360

acggtcaccg tctcctc                                                   377


<210>  42
<211>  125
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  42

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ile Gly Gly Thr Asn Cys Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Tyr Ser Ser Ser Trp Ser Tyr Tyr Tyr Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125 


<210>  43
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  43
gatattctga tgacccagac tccactctct ctgtccgtca cccctggaca gccggcctcc     60

atctcctgca agtctagtca gagcctcctg cttagtgatg gagggaccta tttgtattgg    120

tacctgcaga agccaggcca gcctccacag ctcctgatct atgaagtttc caaccggttc    180

tctggagtgc cagataggtt cagtggcagc gggtcaggga cagatttcac actgaaaatc    240

agccgggtgg aggctgagga tgttggggtt tattactgca tgcaaagtat gcagcttccg    300

atcaccttcg gccaagggac acgactggaa attaaa                              336


<210>  44
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  44

Asp Ile Leu Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Leu Ser 
            20                  25                  30          


Asp Gly Gly Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Pro 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Glu Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ser 
                85                  90                  95      


Met Gln Leu Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 110         


<210>  45
<211>  380
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  45
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc     60

acctgcactg tctctggtgg ctccgtcagc agtggtggtt actactggag ctggatccgg    120

cagcccccag ggaagggact ggagtggatt gggtatatct attacagtgg gagcaccaac    180

tacaacccct ccctcaagag tcgagtcacc atatcagtag acacgtccaa gaaccagttc    240

tccctgaagc tgagctctgt gaccgctgcg gacacggccg tgtattactg tgcgagaggg    300

ggggacagta actacgagga ttactactac tactacggta tggacgtctg gggccaaggg    360

accacggtca ccgtctcctc                                                380


<210>  46
<211>  126
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  46

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Gly Asp Ser Asn Tyr Glu Asp Tyr Tyr Tyr Tyr Tyr 
            100                 105                 110         


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125     


<210>  47
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  47
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc gggcaagtca gagcattagc atctatttac attggtatca gcagaaacca    120

gggaaagccc ctaagctctt gatctctgct gcatccagtt tgcaaagtgg ggtcccgtca    180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagaag tctgcaacct    240

gaagattttg caacttacta ctgtcaacag agttacactt ccccgatcac cttcggccaa    300

gggacacgac tggagattaa a                                              321


<210>  48
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  48

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ile Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Arg Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Ser Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  49
<211>  380
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  49
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc     60

acctgcactg tctctggtgg ctccatcagt agttactact ggagctggat ccggcagccc    120

ccagggaagg gactggagtg gattgggtat atctattaca gtgggagcac caactacaac    180

ccctccctca agagtcgagt caccatatca gtagacacgt ccaagcacca gttctccctg    240

aagctgagct ctgtgaccgc tgcggacacg gccgtgtatt actgtgcgag agattcgagt    300

tactatgata gtagtggtta ttacttatac tactacgcta tggacgtctg gggccaaggg    360

accacggtca ccgtctcctc                                                380


<210>  50
<211>  126
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  50

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys His Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Ser Ser Tyr Tyr Asp Ser Ser Gly Tyr Tyr Leu Tyr Tyr Tyr 
            100                 105                 110         


Ala Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125     


<210>  51
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  51
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc     60

atcaactgca agtccagcca gagtgtttta tacagctcca acaataagaa ctacttagct    120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttcctgggc atctacccgg    180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc    240

atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata ttatactact    300

cctctcactt tcggccctgg gaccaaagtg gatatcaaa                           339


<210>  52
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  52

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Ser Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Thr Thr Pro Leu Thr Phe Gly Pro Gly Thr Lys Val Asp Ile 
            100                 105                 110         


Lys 
    


<210>  53
<211>  357
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  53
gaggtgcaac tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt caccttcagt atctatagca tgaactgggt ccgccaggct    120

ccagggaagg ggctggagtg ggtttcatac attagtagta gtagtagtac catatactac    180

gcagactctg tgaagggccg attcaccatc tccagagaca atgccaagaa ctcactgtat    240

ctgcaaatga acagcctgag agacgaggac acggctgtgt attactgtgc gagagatagg    300

ggtgacttcg atgcttttga tatctggggc caagggacaa tggtcaccgt ctcttca       357


<210>  54
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  54

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gly Asp Phe Asp Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  55
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  55
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc aggcgagtca ggacattacc aactatttga attggtatca gcagaaacca    120

gggaaagccc ctaagctcct gatctacgat gcatccaatt tggaaacagg ggtcccatca    180

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct    240

gaagatattg caacatataa ctgtcaacag tgtgaaaatt tcccgatcac cttcggccaa    300

gggacacgac tggagattaa a                                              321


<210>  56
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  56

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Thr Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Asn Cys Gln Gln Cys Glu Asn Phe Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  57
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  57
gatattgtga tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc     60

atctcctgca ggtctagtca gagcctcctg tatagtaatg gatacaagta tttggattgg    120

tacctgcaga agccagggca gtctccacag ctcctgatct atttgggttc taatcgggcc    180

tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac actgaaaatc    240

agcagagtgg aggctgagga tgttggggtt tattattgca tgcaggctct acaaactccg    300

atcaccttcg gccaagggac acgactggag attaaa                              336


<210>  58
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  58

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Asn Gly Tyr Lys Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 110         


<210>  59
<211>  374
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  59
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc     60

acctgcactg tctctggtgg ctccgtcagc agtggtggtt actactggaa ctggatccgg    120

cagcccccag ggaagggact ggagtggatt gggtatatca attacagtgg gagcaccaac    180

tacaacccct ccctcaagag tcgagtcacc atatcagtag acacgtccaa gaaccagttc    240

tccctgaagc tgagctctgt gaccgctgcg gacacggccg tgtattactg tgcgagagat    300

cgagaactgg aactttacta ctactactac ggtatggacg tctggggcca agggaccacg    360

gtcaccgtct cctc                                                      374


<210>  60
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  60

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Asn Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Arg Glu Leu Glu Leu Tyr Tyr Tyr Tyr Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 


<210>  61
<211>  374
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  61
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttctgagac cctgtccctc     60

acctgcactg tctctggtgg ctccgtcagc agtggtggtt actactggaa ctggatccgg    120

cagcccccag ggaagggact ggagtggatt gggtatatca attacagtgg gagcaccaac    180

tacaacccct ccctcaagag tcgagtcacc atatcagtag acacgtccaa gaaccagttc    240

tccctgaagc tgagctctgt gaccgctgcg gacacggccg tgtattactg tgcgagagat    300

cgagaactgg aactttacta ctactactac ggtatggacg tctggggcca agggaccacg    360

gtcaccgtct cctc                                                      374


<210>  62
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  62

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Asn Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Arg Glu Leu Glu Leu Tyr Tyr Tyr Tyr Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 


<210>  63
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  63
gatattgtga tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc     60

atctcctgca ggtctagtca gagcctcctg tatagtaatg gatacaagta tttggattgg    120

tacctgcaga agccagggca gtctccacag ctcatgatct atttgggttc taatcgggcc    180

tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac actgaaaatc    240

agcagagtgg aggctgagga tgttggggtt tattattgca tgcaggctct acaaactccg    300

atcaccttcg gccaagggac acgactggag attaaa                              336


<210>  64
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  64

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Asn Gly Tyr Lys Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Met Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 110         


<210>  65
<211>  363
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  65
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc     60

tcctgtgcag cgtctggatt caccttcagt agctatggca tgcactgggt ccgccaggct    120

ccaggcaagg ggctggagtg ggtggcagtt atatggtatg atggaagtaa taaatactat    180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat    240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagcagct    300

cgccttgact actactacgg tatggacgtc tggggccaag ggaccacggt caccgtctcc    360

tca                                                                  363


<210>  66
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  66

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Ala Arg Leu Asp Tyr Tyr Tyr Gly Met Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  67
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  67
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtctcc     60

atcacttgcc gggcaagtca gagcattaac agctatttaa attggtttca gcagaagcca    120

gggaaagccc ctcagctcct gatctttggt gcatccggtt tgcaaagtgg ggtcccatca    180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcaacag tctgcaacct    240

gaagattttg caacttacta ctgtcaacag agttacagtt ccccgctcac cttcggccaa    300

gggacacgac tggagattaa a                                              321


<210>  68
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  68

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn Ser Tyr 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Gln Leu Leu Ile 
        35                  40                  45              


Phe Gly Ala Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  69
<211>  351
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  69
caggtgcagc tacagcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc     60

acctgcgctg tctatggtgg gtccttcagt ggttactact ggagctggat ccgccagccc    120

ccagggaagg ggctggagtg gattggggaa atcaatcata gtggaagcac caactacaac    180

ccgtccctca agagtcgagt caccatatca gtagaaacgt ccaagaacca gttctccctg    240

aagctgagct ctgtgaccgc cgcggacacg gctgtgtatt actgtgcgag agataagtgg    300

acctggtact tcgatctctg gggccgtggc accctggtca ctgtctcctc a             351


<210>  70
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  70

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Glu Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Lys Trp Thr Trp Tyr Phe Asp Leu Trp Gly Arg Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  71
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  71
gacatcgaga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc     60

atcaactgca ggtccagcca gagtgtttta tacagctcca gcaataggaa ctacttagct    120

tggtaccagc agaacccagg acagcctcct aagctgctca tttactgggc ttctacccgg    180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc    240

atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata ttatagtact    300

cctcggacgt tcggccaagg gaccaaggtg gaaatcaaa                           339


<210>  72
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  72

Asp Ile Glu Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Ser Asn Arg Asn Tyr Leu Ala Trp Tyr Gln Gln Asn Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  73
<211>  374
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  73
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc     60

acctgcactg tctctggtgg ctccatcagc agtggtggtt actactggag ctggatccgc    120

cagcacccag ggaagggcct ggagtggatg gggaacatct attacagtgg gagcacctac    180

tacaacccgt ccctcaagag tcgagttacc atatcagtag acacgtctga gaaccagttc    240

tccctgaagc tgaactctgt gactgccgcg gacacggccg tatattactg tgcgagaggg    300

ggaactggaa ccaattacta ctactactac ggtatggacg tctggggcca agggaccacg    360

gtcaccgtct cctc                                                      374


<210>  74
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  74

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Met Gly Asn Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Glu Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Gly Thr Gly Thr Asn Tyr Tyr Tyr Tyr Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 


<210>  75
<211>  324
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  75
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc     60

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa    120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gctgggccac tggcatccca    180

aacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag    240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccgct cactttcggc    300

ggagggacca aggtggagat caaa                                           324


<210>  76
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  76

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Trp Ala Thr Gly Ile Pro Asn Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  77
<211>  377
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  77
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc     60

acctgcactg tctctggtgt ctccatcagc agtggtggtt actactggag ctggatccgc    120

cagcacccag ggatgggcct ggagtggatt gggtacatct attacagtgg gagcacctac    180

tacaacccgt ccctcaagag tcgagtcacc atatcagaag acacgtctaa gaaccagttc    240

tccctgaagc tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgagagat    300

tccgagtccg agtatagcag ctcgtcgaac tacggtatgg acgtctgggg ccaagggacc    360

acggtcaccg tctcctc                                                   377


<210>  78
<211>  125
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  78

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Met Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Glu Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Ser Glu Ser Glu Tyr Ser Ser Ser Ser Asn Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125 


<210>  79
<211>  377
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  79
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc     60

acctgcactg tctctggtgt ctccatcagc agtggtggtt actactggag ctggatccgc    120

cagcacccag ggatgggcct ggagtggatt gggtacatct attacagtgg gagcacctac    180

tacaacccgt ccctcaagag tcgagtcacc atatcagaag acacgtctaa gaaccagttc    240

tccctgaagc tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgagagat    300

tccgagtccg agtatagcag ctcgtcgaac tacggtatgg acgtctgggg ccaagggacc    360

acggtcaccg tctcctc                                                   377


<210>  80
<211>  125
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  80

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Met Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Glu Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Ser Glu Ser Glu Tyr Ser Ser Ser Ser Asn Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125 


<210>  81
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  81
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagaatcacc     60

atcacttgcc gggcaagtca gaccattagc agctatttaa attggtatca gcagaaacca    120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaggtgg ggtcccatca    180

aggttcagtg gcagtgtatc tgggacagat ttcaccctca ccgtcagcag tctgcaacct    240

gaagattttg caacttacta ctgtcaacag agttacagta acccgctcac tttcggcgga    300

gggaccaagg tggagatcaa a                                              321


<210>  82
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  82

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Ile Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Gly Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Val Ser Gly Thr Asp Phe Thr Leu Thr Val Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Asn Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  83
<211>  371
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  83
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc     60

tcctgtaagg gttctggata cagttttacc agctactgga tcggctgggt gcgccagatg    120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac    180

agcccgtcct tccaaggcca ggtcaccatg tcagccgaca agtccatcag taccgcctac    240

ctgcagctga gcagccatga aggcctcgga caccgccatg tattactgtg cgagacagat    300

ggctggaaac tacgtacatc acgggtgatc gagacgtcct ggggccaagg gaccacggtc    360

accgtctcct c                                                         371


<210>  84
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  84

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Met Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser His Glu Gly Leu Gly His Arg His Val Leu Leu 
                85                  90                  95      


Cys Glu Thr Asp Gly Trp Lys Leu Arg Thr Ser Arg Val Ile Glu Thr 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120             


<210>  85
<211>  324
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  85
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc     60

ctctcctgca gggccagtca gagtgttatc agcatctact tagcctggta ccagcagaaa    120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca    180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag    240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccgtg cagttttggc    300

caggggacca aactggagat caaa                                           324


<210>  86
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  86

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ile Ser Ile 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Cys Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  87
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  87
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc     60

acctgcactg tctctggtgg ctccatcagc agtggtgatt actactggag ctggatccgc    120

cagcacccag ggaagggcct ggagtggatt gggtacatct attacagtgg gagcacctac    180

tacaacccgt ccctcaggag tcgagttacc atatcagtag acacgtctaa gaaccagttc    240

tccctgaagc tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgagagcg    300

gattacgatt tttggagtgg ttattttgac tactggggcc agggaaccct ggtcaccgtc    360

tcctca                                                               366


<210>  88
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  88

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Arg Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ala Asp Tyr Asp Phe Trp Ser Gly Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  89
<211>  322
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  89
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc gggcaagtca gggcattaga aatgatttag gctggtatca gcagatacct    120

gggaaagccc ctaagcgcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca    180

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcaacag cctgcagcct    240

gaagattttg caacttatta ctgtctacag cataatggtt acccgtggac gttcggccaa    300

gggaccaagg tggaaatcaa ac                                             322


<210>  90
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  90

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Ile Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Gly Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  91
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  91
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc     60

acctgcactg tctctggtgg ctccatcagc agtggtgatt actactggag ctggatccgc    120

cagcacccag ggaagggcct ggagtggatt ggatacatct attacagtgg gagcacctac    180

tacaacccgt ccctcaagag tcgagttacc atatcagtag acacgtctaa gaaccagttc    240

tccctgaagc tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgagagcg    300

gattacgatt tttggagtgg ttattttgac tactggggcc agggaaccct ggtcaccgtc    360

tcctca                                                               366


<210>  92
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  92

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ala Asp Tyr Asp Phe Trp Ser Gly Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  93
<211>  322
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  93
gacttccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc gggcaagtca ggacattcga aatgatttag gctggtatcg gcagaaacct    120

gggaaagccc ctaagcgcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca    180

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct    240

gaagattttg caacttatta ctgtctacag cataatagtt acccgtggac gttcggccaa    300

gggaccaagg tggaaatcaa ac                                             322


<210>  94
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  94

Asp Phe Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Arg Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  95
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  95
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc     60

acctgcactg tctctggtgg ctccatcagc agtggtgatt actactggag ctggatccgc    120

cagcacccag ggaagggcct ggagtggatt ggatacatct attacagtgg gagcacctac    180

tacaacccgt ccctcaagag tcgagttacc atatcaatag acacgtctaa gaaccagttc    240

tccctgaagc tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgagagcg    300

gattacgatt tttggaatgg ttattttgac tactggggcc agggaaccct ggtcaccgtc    360

tcctca                                                               366


<210>  96
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  96

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Ile Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ala Asp Tyr Asp Phe Trp Asn Gly Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  97
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  97
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc gggcaagtca ggacattaga aatgatttag gctggtatcg gcagaaacct    120

gggaaagccc ctaagcgcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca    180

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct    240

gaagattttg caacttatta ctgtctacag cataatagtt acccgtggac gttcggccaa    300

gggaccaagg tggaaatcaa a                                              321


<210>  98
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  98

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Arg Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  99
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  99
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc ctacacagac cctgtccctc     60

acctgcactg tctctggtgg ctccatcagc agtggtgatt actactggag ctggatccgc    120

cagcacccag ggaagggcct ggagtggatt gggtacatct attacagtgg gagcacctac    180

tacaacccgt ccctcaagag tcgacttacc atatcagtag acacgtctaa gaaccagttc    240

tccctgaagc tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgagagca    300

gattacgatt tttggagtgg ttactttgac tactggggcc agggaaccct ggtcaccgtc    360

tcctca                                                               366


<210>  100
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  100

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ala Asp Tyr Asp Phe Trp Ser Gly Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  101
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  101
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc gggcaagtca gggcattaga aatgatttag gctggtatca gcagaaacca    120

gggaaagccc ctaagcgcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca    180

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct    240

gaagattttg caacttatta ctgtctacag cataataatt acccgtggac gttcggccaa    300

gggaccaagg tggaaatcaa a                                              321


<210>  102
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  102

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Asn Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  103
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  103
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc     60

acctgcactg tctctggtgg ctccatcagt agtggtgatt actactggag ctggatccgc    120

cagcacccag ggaagggcct ggagtggatt gggtacatct attacagtgg gagcacctac    180

tacaacccgt ccctcaagag tcgagttacc atatcagtag acacgtctaa gaaccagttc    240

tccctgaagt tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgagagcc    300

gattacgatt tttggagtgg ttattttgac tactggggcc agggaaccct ggtcaccgtc    360

tcctca                                                               366


<210>  104
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  104

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ala Asp Tyr Asp Phe Trp Ser Gly Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  105
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  105
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc gggcaagtca gggcattaga aatgatttag gctggtatca gcagaaacca    120

gggaaagccc ctaagcgcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca    180

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct    240

gaagattttg caacttatta ctgtctacag cataataatt acccgtggac gttcggccaa    300

gggaccaagg tggaaatcaa a                                              321


<210>  106
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  106

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Asn Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  107
<211>  351
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  107
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc     60

acctgcactg tctctggtgg ctccatcagc agtggtggtt actactggag ctggatccgc    120

cagcacccag ggaagggcct ggagtggatt gggtacatct attacagtgg gagcacctac    180

tacaacccgt ccctcaagag tcgagttacc atatcagtag acacgtctaa gaaccagttc    240

tccctgaagc tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgagagag    300

gacgacggta tggacgtctg gggccaaggg accacggtca ccgtctcctc a             351


<210>  108
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  108

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Asp Asp Gly Met Asp Val Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  109
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  109
gatattgtga tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc     60

atttcctgca ggtctagtca gagcctcctg catagtaatg gatacaacta tttggaatgg    120

tacctgcaga agccagggca gtccccacag ttcatgattt atttggggtc taatcgggcc    180

tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac actgaaaatc    240

agcagagtgg aggctgagga tgttggggtt tattactgca tgcaagctct acaaactccg    300

atcaccttcg gccaagggac acgactggag attaaa                              336


<210>  110
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  110

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Phe Met Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 110         


<210>  111
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  111
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc     60

acctgcactg tctctggtgg ctccatcagc agtggtgatt actactggag ctggatccgc    120

cagtacccag ggaagggcct ggagtggatt gggtacatct attacagtgg gagcacctac    180

tacaacccgt ccctcaagag tcgagttacc atatcagtag acacgtctaa gaaccagttc    240

tccctgaagc tgaggtctgt gactgccgcg gacacggccg tgtattactg tgcgagagcg    300

gattacgatt tttggagtgg ttattttgac tactggggcc agggaaccct ggtcaccgtc    360

tcctca                                                               366


<210>  112
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  112

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln Tyr Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ala Asp Tyr Asp Phe Trp Ser Gly Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  113
<211>  322
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  113
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc gggcaagtca gggcattaga aatgatttag gctggtatca gcagaaacca    120

gggaaagccc ctaagcgcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca    180

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct    240

gaagattttg caacttatta ctgtctacag cataatactt acccgtggac gttcggccaa    300

gggaccaagg tggaaatcaa ac                                             322


<210>  114
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  114

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Thr Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  115
<211>  372
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  115
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc     60

acctgcactg tctctggtgg ctccgtcagc agtggtggtt actactggag ctggatccgg    120

cagcccccag ggaagggact ggagtggatt gggtatatct attacagtgg gagcaccaac    180

tacaacccct ccctcaagag tcgagtcacc atatcagtag acacgtccaa gaaccagttc    240

tccctgaagc tgagctctgt gaccgctgcg gacacggccg tgtattactg tgcgagagat    300

ggggacgtgg atacagctat ggtcgatgct tttgatatct ggggccaagg gacaatggtc    360

accgtctcct ca                                                        372


<210>  116
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  116

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Gly Asp Val Asp Thr Ala Met Val Asp Ala Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 


<210>  117
<211>  324
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  117
gaaattgtat tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc     60

ctctcctgca gggccagtca gagtttaagc ggcaactact tagcctggta ccagcagaag    120

cctggccagg ctcccaggct catcatctgt ggtgcatcca gcagggccac tggcatccca    180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcac aagactggag    240

cctgaagatt ttgcagtgta ttactgtcag cagtatgata ggtcaccgct cactttcggc    300

ggagggacca aggtggagat caaa                                           324


<210>  118
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  118

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Leu Ser Gly Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Ile 
        35                  40                  45              


Ile Cys Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Arg Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  119
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  119
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc     60

acctgcactg tctctggtgg ctccatcagc agtggtgatt actactggag ctggatccgc    120

cagcacccag ggaagggcct ggagtggatt gggtacatct attacagtgg gagcacctac    180

tacaacccgt ccctcaagag tcgagttacc atatcagtag acacgtctaa gaaccagttc    240

tccctgaagc tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgagagga    300

gattacgatt tttggagtgg agagtttgac tactggggcc agggaaccct ggtcaccgtc    360

tcctca                                                               366


<210>  120
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  120

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Asp Tyr Asp Phe Trp Ser Gly Glu Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  121
<211>  386
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  121
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc     60

acctgcactg tctctggtgg ctccatcagc agtggtggtt actactggag ctggatccgc    120

cagcacccag ggaagggcct ggagtggatt gggtacatct atgacagtgg gagcacctac    180

tacaacccgt ccctcaagag tcgagttacc atatcagtag acacgtctaa gaaccagttc    240

tccctgaagc tgaggtctgt gactgccgcg gacacggccg tgtattactg tgcgagagat    300

caggggcagg acggatacag ctatggttac ggctactact acggtatgga cgtctggggc    360

caagggacca cggtcaccgt ctcctc                                         386


<210>  122
<211>  128
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  122

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Asp Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Gln Gly Gln Asp Gly Tyr Ser Tyr Gly Tyr Gly Tyr 
            100                 105                 110         


Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


<210>  123
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  123
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc aggcgagtca ggacattagc aattatttaa attggtatca gcagaaacca    120

gggaaagccc ctaaactcct gatctacgtt gcatccaatt tggaaacagg ggtcccatca    180

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct    240

gaagatattg caacatatta ctgtcaacag tgtgataatc tccctctcac tttcggcgga    300

gggaccaagg tggagatcaa a                                              321


<210>  124
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  124

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Val Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Cys Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  125
<211>  365
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  125
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc     60

acctgcactg tctctggtgg ctccatcagc agtggtgatt actactggag ctggatccgc    120

cagcacccag ggaagggcct ggagtggatt ggatacatct attacagtgg gagcacctac    180

tacaacccgt ccctcaagag tcgagttacc atatcagtag acacgtctaa gaaccagttc    240

tccctgaagc tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgagagcg    300

gattacgatt tttggagtgg ttattttgac tactggggcc agggaaccct ggtcaccgtc    360

tcctc                                                                365


<210>  126
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  126

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ala Asp Tyr Asp Phe Trp Ser Gly Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120     


<210>  127
<211>  322
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  127
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc gggcaagtca ggacattaga aatgatttag gctggtatcg gcagaaacct    120

gggaaagccc ctaagcgcct gatctatgct gcatcccgtt tgcaaagtgg ggtcccatca    180

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct    240

gaagattttg caacttatta ctgtctacag cataatagtt acccgtggac gttcggccaa    300

gggaccaagg tggaaatcaa ac                                             322


<210>  128
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  128

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Arg Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  129
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  129
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc     60

acctgcactg tctctggtgg ctccatcagc agtggtgatt actactggag ctggatccgc    120

cagcacccag ggaagggcct ggagtggatt gggtacatct attacagtgg gagcacctac    180

tacaacccgt ccctcaagag tcgagttacc atatcagtag acacgtctaa gaaccagttc    240

tccctgaagc tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgagagcc    300

gattacgatt tttggagtgg ttattttgac tactggggcc agggaaccct ggtcaccgtc    360

tcctca                                                               366


<210>  130
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  130

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ala Asp Tyr Asp Phe Trp Ser Gly Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  131
<211>  322
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  131
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc gggcaagtca gggcattaga aatgatttag gctggtatca gcagaaacca    120

gggaaagccc ctaagcgcct gatctatgct gcatccagtt tgcaaaatgg ggtcccatca    180

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct    240

gaagattttg caacttatta ctgtctacag cataatagtt acccgtggac gttcggccaa    300

gggaccaagg tggaaatcaa ac                                             322


<210>  132
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  132

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Asn Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  133
<211>  365
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  133
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc     60

acctgcactg tctctggtgg ctccatcagc agtggtgatt actactggag ctggatccgc    120

cagcacccag ggaagggcct ggagtggatt gggtacatct attacagtgg gagcacctac    180

tacaacccgt ccctcaagag tcgagttacc atatcagtag acacgtctaa gaaccagttc    240

tccctgaagc tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgagagcg    300

gattacgatt tttggagtgg ttattttgac tactggggcc agggaatcct ggtcaccgtc    360

tcctc                                                                365


<210>  134
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  134

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ala Asp Tyr Asp Phe Trp Ser Gly Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Ile Leu Val Thr Val Ser 
        115                 120     


<210>  135
<211>  322
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  135
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc gggcaagtca gggcattaga aatgatttag gctggtatca gcagaaacca    120

gggaaagccc ctaagcgcct gatttatgct gcatccagtt tgcaaagtgg ggtcccatca    180

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct    240

gaagattttg caacttatta ctgtctacag cataatagtt acccgtggac gttcggccaa    300

gggaccaagg tggaaatcaa ac                                             322


<210>  136
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  136

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  137
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  137
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc     60

acctgcactg tctctggtgg ctccatcagt agtggtgatt actactggag ctggatccgc    120

cagcacccag ggaagggcct ggagtggatt gggtacatct attacagtgg gagcacctac    180

tacaacccgt ccctcaagag tcgagttacc atatcagtag acacgtctaa gaaccagttc    240

tccctgaagt tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgagagcc    300

gattacgatt tttggaatgg ttattttgac tactggggcc agggaaccct ggtcaccgtc    360

tcctca                                                               366


<210>  138
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  138

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ala Asp Tyr Asp Phe Trp Asn Gly Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  139
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  139
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc gggcaagtca gggcattaga aatgatttag gctggtatca gcagaaacca    120

gggaaagccc ctaagcgcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca    180

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct    240

gaagattttg caacttatta ctgtctacag cataataatt acccgtggac gttcggccaa    300

gggaccaagg tggaaatcaa a                                              321


<210>  140
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  140

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Asn Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  141
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  141
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc     60

acctgcactg tctctggtgg ctccatcagc agtggtgatt actactggag ctggatccgc    120

cagcacccag ggaagggcct ggagtggatt gggtacatct attacagtgg gagcacctac    180

tacaacccgt ccctcaagag tcgagttacc atatcagtag acacgtctaa gaaccagttc    240

tccctgaagc tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgagagcc    300

gattacgatt tttggagtgg ttattttgac tactggggcc agggaaccct ggtcaccgtc    360

tcctca                                                               366


<210>  142
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  142

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ala Asp Tyr Asp Phe Trp Ser Gly Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  143
<211>  322
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  143
gacatccagc tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc gggcaagtca gggcattaga aatgatttag gctggtatca gcagaaacca    120

gggaaagccc ctaagcgcct gatctatgct gcatccagtt tgcaaaatgg ggtcccatca    180

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct    240

gaagattttg caacttatta ctgtctacag cataatagtt acccgtggac gttcggccaa    300

gggaccaagg tggaaatcaa ac                                             322


<210>  144
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  144

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Asn Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  145
<211>  365
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  145
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc     60

acctgcactg tctctggtgg ctccatcagc agtggtgatt actactggag ctggatccgc    120

cagtacccag ggaagggcct ggagtggatt gggtacatct attacagtgg gagcacctac    180

tacaacccgt ccctcaagag tcgagttacc atatcagtag acacgtctaa gaaccagttc    240

tccctgaagc tgggctctgt gactgccgcg gacacggccg tgtatttctg tgcgagagcc    300

gattacgatt tttggagtgg ttattttgac ttctggggcc agggaaccct ggtcaccgtc    360

tcctc                                                                365


<210>  146
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  146

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln Tyr Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Gly Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Arg Ala Asp Tyr Asp Phe Trp Ser Gly Tyr Phe Asp Phe Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120     


<210>  147
<211>  322
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  147
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc gggcaagtca gggcattaga aatgatttag gctggtatca gcagaaacca    120

gggaaagccc ctaagcgcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca    180

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct    240

gaagattttg caacttatta ctgtctacag cataatggtt acccgtggac gttcggccaa    300

gggaccaagg tggaaatcaa ac                                             322


<210>  148
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  148

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Gly Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  149
<211>  365
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  149
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc     60

acctgcactg tctctggtgg ctccatcagc agtggtgatt actactggag ctggatccgc    120

cagtacccag ggaagggcct ggagtggatt gggtacatct attacagtgg gagcacctac    180

tacaacccgt ccctcaagag tcgagttacc atatcagtag acacgtctaa gaaccagttc    240

tccctgaagc tgggctctgt gactgccgcg gacacggccg tgtatttctg tgcgagagcc    300

gattacgatt tttggagtgg ttattttgac ttctggggcc agggaaccct ggtcaccgtc    360

tcctc                                                                365


<210>  150
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  150

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln Tyr Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Gly Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Arg Ala Asp Tyr Asp Phe Trp Ser Gly Tyr Phe Asp Phe Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120     


<210>  151
<211>  322
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  151
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc gggcaagtca gggcattaga aatgatttag gctggtatca gcagaaacca    120

gggaaagccc ctaagcgcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca    180

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct    240

gaagattttg caacttatta ctgtctacag cataatggtt acccgtggac gttcggccaa    300

gggaccaagg tggaaatcaa ac                                             322


<210>  152
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  152

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Gly Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  153
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  153
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc     60

acctgcactg tctctggtgg ctccatcagt agtggtgatt actactggag ctggatccgc    120

cagcacccag ggaagggcct ggagtggatt gggtacatct attacagtgg gagcacctac    180

tacaacccgt ccctcaagag tcgagttacc atatcagtag acacgtctaa gaaccagttc    240

tccctgaagc tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgagagcg    300

gattacgatt tttggagtgg ttattttgac tcctggggcc agggaaccct ggtcaccgtc    360

tcctca                                                               366


<210>  154
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  154

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ala Asp Tyr Asp Phe Trp Ser Gly Tyr Phe Asp Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  155
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  155
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc gggcaagtca gggcattaga aatgatttag gctggtatca gcagatacct    120

gggaaagccc ctaagcgcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca    180

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct    240

gaagattttg caacttatta ctgtctacag cataatggtt acccgtggac gttcggccaa    300

gggaccaagg tggaaatcaa a                                              321


<210>  156
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  156

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Ile Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Gly Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  157
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  157
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc     60

tcctgcaagg cttctggtta cacctttacc aactatggta tcagctgggt gcggcaggcc    120

cctggacaag ggcttgagtg gatgggatgg atcagcgctt acgatggtta cagaaactat    180

gcacagaagc tccagggcag agtcaccatg accacagaca catccacgac cactgcctac    240

atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagagatgtt    300

caagactacg gtgactacga ctactttgac tactggggcc agggaaccct ggtcaccgtc    360

tcctca                                                               366


<210>  158
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  158

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asp Gly Tyr Arg Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Val Gln Asp Tyr Gly Asp Tyr Asp Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  159
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  159
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc gggcaagtca gagcattagc agttatttaa attggtatca gcagaaacca    120

gggaaagccc ctaacctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca    180

agattcaggg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct    240

gaagattttg caacttacta ctgtcaacag agttacagta cccccatcac cttcggccaa    300

gggacacgac tggagattaa a                                              321


<210>  160
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  160

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  161
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  161
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc ctttacagac cctgtccctc     60

acctgcactg tctctggtgg ctccatcagc agtggtgatt actactggag ctggatccgc    120

cagcacccag ggaagggcct ggagtggatt gggtacatct attacagtgg gaccacctac    180

tacaacccgt ccctcaagag tcgagttacc atatcagtag acacgtctaa gaaccagttc    240

gccctgaagc tgaactctgt gactgccgcg gacacggccg tgtattactg tgcgagagcc    300

gattacgatt tttggagtgg ttattttgac tactggggcc agggaaccct ggtcaccgtc    360

tcctca                                                               366


<210>  162
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  162

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Leu Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Thr Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ala Leu Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ala Asp Tyr Asp Phe Trp Ser Gly Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  163
<211>  322
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  163
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc gggcaggtca gggcattaga aatgatttag gctggtatca gcagaaacca    120

gggaaagccc ctcagcgcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca    180

aggttcagcg gcagtggatc tgggacagaa ttctctctca caatctccag cctgcagcct    240

gaagattttg caacttatta ctgtctacag cataatagtt acccgtggac gttcggccaa    300

gggaccaagg tggaaatcaa ac                                             322


<210>  164
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  164

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Gly Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Gln Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  165
<211>  369
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  165
caggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc     60

tcctgtgcag cctctggatt caccttcagt gactactaca tgagctggat ccgccaggct    120

ccagggaagg ggctggagtg ggtttcatat attagtagta gtggtaataa catataccac    180

gcagactctg tgaagggccg attcaccatc tccagggaca acgccaagaa ctcactgtat    240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagagagaga    300

tatagtggct acgacgaccc tgatggtttt gatatctggg gccaagggac aatggtcacc    360

gtctcttca                                                            369


<210>  166
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  166

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Asn Asn Ile Tyr His Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Arg Tyr Ser Gly Tyr Asp Asp Pro Asp Gly Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210>  167
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  167
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc aggcgagtca ggacattagc aactatttaa gttggtttca gcagaaacca    120

gggaaagccc ctaagctcct gatccacgat gcatccaatt tggaaacagg ggtcccttca    180

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct    240

gaagatattg caacatatta ctgtcaacag tatgataatc ccccgtgcag ttttggccag    300

gggaccaagc tggagatcaa a                                              321


<210>  168
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  168

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Pro Pro Cys 
                85                  90                  95      


Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  169
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  169
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc     60

acctgcactg tctctggtgg ctccatcagc agtggttatt actactggag ctggatccgc    120

cagcacccag ggaagggcct ggagtggatt gggtacatct attacagtgg gaccacctac    180

tacaatccgt ccttcaagag tcgagttacc atatcagtag acacgtctaa gaaccagttc    240

tccctgaaac tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgagagcc    300

gattacgatt tttggagtgg tcactttgac tactggggcc agggaaccct ggtcaccgtc    360

tcctca                                                               366


<210>  170
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  170

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Thr Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Phe Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ala Asp Tyr Asp Phe Trp Ser Gly His Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  171
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  171
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc gggcaagtca gggcattaga aatgatttag gctggtatca gcagaaacca    120

gggaaagccc ctaagcgcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca    180

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct    240

gaagattttg caacttatta ctgtctacag cataatagtt acccgtggac gttcggccaa    300

gggaccaagg tggaaatcaa a                                              321


<210>  172
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  172

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  173
<211>  365
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  173
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc     60

tcctgcaagg cttctggtta cacctttacc agctatggta tcagctgggt gcgacaggcc    120

cctggacaag gacttgagtg gatgggatgg atcagcgctt acgatggtca cacaaactat    180

gcacagaagc tccagggcag agtcaccatg accacagaca catccacgaa cacagcctac    240

atggagctga ggagcctgag atctgacgac acggccgttt attactgtgc gagagacccc    300

catgactaca gtaactacga ggcttttgac ttctggggcc agggaaccct ggtcaccgtc    360

tcctc                                                                365


<210>  174
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  174

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asp Gly His Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro His Asp Tyr Ser Asn Tyr Glu Ala Phe Asp Phe Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120     


<210>  175
<211>  519
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  175
atgaggtccc ctgctcagct cctggggctc ctgctactct ggctccgagg tgccagatgt     60

gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc    120

atcacttgcc gggcaagtca gagcattagc agttatttaa attggtatca gcagaaacca    180

gggaaagccc ctaacctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca    240

agattcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct    300

gaagattttg caacttacta ctgtcaacag agttacagta cccccatcac cttcggccaa    360

gggacacgac tggagattaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca    420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat    480

cccagagagg ccaaagtaca gtggaaggtg gataacgcc                           519


<210>  176
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  176

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  177
<211>  534
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  177
accatggact ggacctggag ggtccttttc ttggtggcag cagcaacagg tgcccactcc     60

caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc    120

tcctgcaagg cttctggtta cacctttacc aactatggta tcagctgggt gcggcaggcc    180

cctggacaag ggcttgagtg gatgggatgg atcagcgctt acgatggtta cagaaactat    240

gcacagaagc tccagggcag agtcaccatg accacagaca catccacgac cactgcctac    300

atggagctga ggagcctgag atctgacgac acggccgtgt attactgtgc gagagatgtt    360

caagactacg gtgactacga ctactttgac tactggggcc agggaaccct ggtcaccgtc    420

tcctcagctt ccaccaaggg cccatccgtc ttccccctgg tgccctgctc caggagcacc    480

tccgagagca cagccgccct gggctgcctg gtcaaggact acttccccga accg          534


<210>  178
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  178

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asp Gly Tyr Arg Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Val Gln Asp Tyr Gly Asp Tyr Asp Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  179
<211>  504
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  179
cagctcctgg ggctcctgct actctggctc cgaggtgcca gatgtgacat ccagatgacc     60

cagtctccat cctccctgtc tgcatctgta ggagacagag tcaccatcac ttgccgggca    120

agtcagagca ttagcagtta tttaaattgg tatcagcaga aaccagggaa agcccctaac    180

ctcctgatct atgctgcatc cagtttgcaa agtggggtcc catcaagatt cagtggcagt    240

ggatctggga cagatttcac tctcaccatc agcagtctgc aacctgaaga ttttgcaact    300

tactactgtc aacagagtta cagtaccccc atcaccttcg gccaagggac acgactggag    360

attaaacgaa ctgtggctgc accatctgtc ttcatcttcc cgccatctga tgagcagttg    420

aaatctggaa ctgcctctgt tgtgtgcctg ctgaataact tctatcccag agaggccaaa    480

gtacagtgga aggtggataa cgcc                                           504


<210>  180
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  180

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  181
<211>  493
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  181
catctgtggt tcttcctcct gctggtggca gctcccagat gggtcctgtc ccaggtgcag     60

ctgcaggagt cgggcccagg actggtgaag ccttcacaga ccctgtccct cacctgcact    120

gtctctggtg gctccatcaa cagtggtgat tactactgga gctggatccg ccagcaccca    180

gggaagggcc tggagtggat tgggtacatc tattacagtg ggagcaccta ctacaacccg    240

tccctcaaga gtcgagttac catatcagta gacacgtcta agaaccagtt ctccctgaag    300

ctgagctctg tgactgccgc ggacacggcc gtgtattact gtgcgagagc agattacgat    360

ttttggagtg gttactttga ctactggggc cagggaaccc tggtcaccgt ctcctcagcc    420

tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc    480

acaacggccc tgg                                                       493


<210>  182
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  182

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Asn Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ala Asp Tyr Asp Phe Trp Ser Gly Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  183
<211>  518
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  183
atgagggtcc ctgctcagct cctggggctc ctgctgctct ggttcccagg tgccaggtgt     60

gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc    120

atcacttgcc gggcaagtca gggcattaga aatgatttag gctggtatca gcagaaacca    180

gggaaagccc ctaagcgcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca    240

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct    300

gaagattttg caacttatta ctgtctacag cataatagtt acccgtggac gttcggccaa    360

gggaccaagg tggaaatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca    420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat    480

cccagagagg ccaaagtaca gtggaaggtg gataacgc                            518


<210>  184
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  184

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  185
<211>  436
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  185
tggttcttcc ttctgctggt ggcagctccc agatgggtcc tgtcccaggt gcagctgcag     60

gagtcgggcc caggactggt gaagccttca cagaccctgt ccctcacctg cactgtctct    120

ggtggctcca tcagcagtgg tggttactac tggagctgga tccgccagca cccagggaag    180

ggcctggagt ggattgggta catctattac agtgggagca cctactacaa cccgtccctc    240

aagagtcgag ttaccatatc agtagacacg tctaagaacc agttctccct gaagctgagc    300

tctgtgactg ccgcggacac ggccgtgtat tactgtgcga gagatggcta tgatagtagt    360

ggttattacc acggctactt tgactactgg ggccagggaa ccctggtcac cgtctcctca    420

gcctccacca agggcc                                                    436


<210>  186
<211>  125
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  186

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Gly Tyr Asp Ser Ser Gly Tyr Tyr His Gly Tyr Phe 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  187
<211>  521
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  187
caggtcttca tttctctgtt gctctggatc tctggtgcct acggggacat cgtgatgacc     60

cagtctccag actccctggc tgtgtctctg ggcgagaggg ccaccatcaa ctgcaagtcc    120

agccagagtg ttttatacag ctccaacaat aagaactact tagcttggta ccagcagaaa    180

ccaggacagc ctcctaagct gctcatttac tgggcatcta cccgggaatc cggggtccct    240

gaccgattca gtggcagcgg gtctgggaca gatttcactc tcaccatcag cagcctgcag    300

gctgaagatg tggcagttta ttactgtcag caatattata gtactccgct cactttcggc    360

ggagggacca aggtggagat caaacgaact gtggctgcac catctgtctt catcttcccg    420

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc    480

tatcccagag aggccaaagt acagtggaag gtggataacg c                        521


<210>  188
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  188

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  189
<211>  455
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  189
ctgtggttct tcctcctgct ggtggcagct cccagatggg tcctgtccca ggtgcagctg     60

caggagtcgg gcccaggact ggtgaagcct tcacagaccc tgtccctcac ctgcactgtc    120

tctggtggct ccatcagtag tggtgattac tactggagct ggatccgcca gcacccaggg    180

aagggcctgg agtggattgg gtacatctat tacagtggga gcacctacta caacccgtcc    240

ctcaagagtc gagttaccat atcagtagac acgtctaaga accagttctc cctgaagttg    300

agctctgtga ctgccgcgga cacggccgtg tattactgtg cgagagccga ttacgatttt    360

tggagtggtt attttgacta ctggggccag ggaaccctgg tcaccgtctc ctcagcctcc    420

accaagggcc catcggtctt ccccctggca ccctc                               455


<210>  190
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  190

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ala Asp Tyr Asp Phe Trp Ser Gly Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  191
<211>  442
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  191
gtgcccgctc agcgcctggg gctcctgctg ctctggttcc caggtgccag gtgtgacatc     60

cagatgaccc agtctccatc ctccctgtct gcatctgtag gagacagagt caccatcact    120

tgccgggcaa gtcagggcat tagaaatgat ttaggctggt atcagcagaa accagggaaa    180

gcccctaagc gcctgatcta tgctgcatcc agtttgcaaa gtggggtccc atcaaggttc    240

agcggcagtg gatctgggac agaattcact ctcacaatca gcagcctgca gcctgaagat    300

tttgcaactt attactgtct acagcataat aattacccgt ggacgttcgg ccaagggacc    360

aaggtggaaa tcaaacgaac tgtggctgca ccatctgtct tcatcttccc gccatctgat    420

gagcagttga aatctggaac tg                                             442


<210>  192
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  192

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Asn Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  193
<211>  427
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  193
tggttcttcc ttctgctggt ggcagctccc agatgggtcc tgtcccaggt gcagctgcag     60

gagtcgggcc caggactggt gaagccttca cagaccctgt ccctcacctg cactgtctct    120

ggtggctcca tcagcagtgg tgattactac tggagctgga tccgccagca cccagggaag    180

ggcctggagt ggattgggta catctattac agtgggagca cctactacaa cccgtccctc    240

aagagtcgag ttaccatatc agtagacacg tctaagaacc agttctccct gaagctgagc    300

tctgtgactg ccgcggacac ggccgtgtat ttctgtgcga gagccgatta cgatttttgg    360

agtggttatt ttgactactg gggccaggga accctggtca ccgtctcctc agcctccacc    420

aagggcc                                                              427


<210>  194
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  194

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Arg Ala Asp Tyr Asp Phe Trp Ser Gly Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  195
<211>  518
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  195
atgagggtcc ccgctcagct cctggggctc ctgctgctct ggttcccagg tgccaggtgt     60

gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc    120

atcacttgcc gggcaagtca gggcattaga aatgatttag gctggtatca gcagaaacca    180

gggaaagccc ctaagcgcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca    240

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct    300

gaagattttg caacttatta ctgtctacag cataatactt acccgtggac gttcggccaa    360

gggaccaagg tggaaatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca    420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat    480

cccagagagg ccaaagtaca gtggaaggtg gataacgc                            518


<210>  196
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  196

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Thr Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  197
<211>  428
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  197
tggttcttcc ttctgctggt ggcagctccc agatgggtcc tgtcccaggt gcagctgcag     60

gagtcgggcc caggactggt gaagccttca cagaccctgt ccctcacctg cactgtctct    120

ggtggctcca tcagcagtgg tgattactac tggagctgga tccgccagca cccagggaag    180

ggcctggagt ggattgggta catctattac agtgggagca cctactacaa cccgtccctc    240

aagagtcgag ttaccatatc agtagacacg tctaagaacc agttctccct gaagctgagc    300

tctgtgactg ccgcggacac ggccgtgtat ttctgtgcga gagccgatta cgatttttgg    360

aatggttatt ttgactactg gggccaggga accctggtca ccgtctcctc agcctccacc    420

aagggccc                                                             428


<210>  198
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  198

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Arg Ala Asp Tyr Asp Phe Trp Asn Gly Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  199
<211>  519
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  199
atgagggtcc ccgctcagct cctggggctc ctgctgctct ggttcccagg tgccaggtgt     60

gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc    120

atcacttgcc gggcaagtca gggcattaga aatgatttag gctggtatca gcagaaacca    180

gggaaagccc ctaagcgcct gatctatgct gcttccagtt tgcaaagtgg ggtcccatca    240

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct    300

gaagattttg caacttatta ctgtctacag cataatactt acccgtggac gttcggccaa    360

gggaccaagg tggaaatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca    420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat    480

cccagagagg ccaaagtaca gtggaaggtg gataacgcc                           519


<210>  200
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  200

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Thr Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  201
<211>  398
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  201
ttggtggcag cagctacagg cacccacgcc caggtccagc tggtacagtc tggggctgag     60

gtgaagaagc ctggggcctc agtgaaggtc tcctgcaagg tttccggata caccctcact    120

gaattatcca tgtactgggt gcgacaggct cctggaaaag ggcttgagtg gatgggaggt    180

tttgatcctg aagatggtga aacaatctac gcacagaagt tccagggcag agtcaccatg    240

accgaggaca catctacaga cacagcctac atggagctga gcagcctgag atctgaggac    300

acggccgtgt attactgtgc aactgggtgg aactacgtct ttgactactg gggccaggga    360

accctggtca ccgtctcctc agcctccacc aagggccc                            398


<210>  202
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  202

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu 
            20                  25                  30          


Ser Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Trp Asn Tyr Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  203
<211>  388
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  203
ggatccagtg gggatattgt gatgactcag tctccactct ccctgcccgt cacccctgga     60

gagccggcct ccatctcctg caggtccagt cagagcctcc tgcatagtaa tggatacaac    120

tatttggatt ggtacctgca gaagccaggg cagtctccac agctcctgat ctatttggat    180

tctcatcggg cctccggggt ccctgacagg ttcagtggca gtggatcagg cacagatttt    240

acactgaaaa tcagcagagt ggaggctgag gatgttgggg tttattactg catgcaagct    300

ctacaaactc cgctcacttt cggcggaggg accaaggtgg agatcaaacg aactgtggct    360

gcaccatctg tcttcatctt cccgccat                                       388


<210>  204
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  204

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Asp Ser His Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  205
<211>  446
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  205
tggttcttcc ttctgctggt ggcagctccc agatgggtcc tgtcccaggt gcagctgcag     60

gagtcgggcc caggactggt gaagccttca cagaccctgt ccctcacctg cactgtctct    120

ggtggctcca tcagcagtgg tgattactac tggagctgga tccgccagca cccagggaag    180

ggcctggagt ggattgggta catctattac agtgggagca cctactacaa cccgtccctc    240

aagagtcgag ttaccatatc agtagacacg tctaagaacc agttctccct gaagctgagc    300

tctgtgactg ccgcggacac ggccgtgtat ttctgtgcga gagccgatta cgatttttgg    360

agtggttatt ttgactactg gggccaggga accctggtca ccgtctcctc agcctccacc    420

aagggcccat cgagtcttcc ccctgg                                         446


<210>  206
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  206

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Arg Ala Asp Tyr Asp Phe Trp Ser Gly Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  207
<211>  519
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  207
atgagggtcc ccgctcagct cctggggctc ctgctgctct ggttcccagg tgccaggtgt     60

gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc    120

atcacttgcc gggcaagtca gggcattaga aatgatttag gctggtatca gcagaaacca    180

gggaaagccc ctaagcgcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca    240

aggttcagcg gcagtggatc tgggacaaaa ttcactctca ctatcagcag cctgcagcct    300

gaagattttg caacttatta ctgtctacag cataatactt acccgtggac gttcggccaa    360

gggaccaagg tggaaatcag acgaactgtg gctgcaccat ctgtcttcat cttcccgcca    420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat    480

cccagagagg ccaaagtaca gtggaaggtg gataacgcc                           519


<210>  208
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  208

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Lys Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Thr Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Arg 
            100                 105         


<210>  209
<211>  564
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  209
accatgaaac atctgtggtt cttcctcctg ctggtggcag ctcccagatg ggtcctgtcc     60

caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc    120

acctgcactg tctctggtgg ctccatcagc agtggtgatt actactggag ctggatccgc    180

cagcacccag ggaagggcct ggagtggatt gggtacatct attacagtgg gagcacctac    240

tacaacccgt ccctcaagag tcgagttacc atatcagtag acacgtctaa gaaccagttc    300

tccctgaagc tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgagagcg    360

gattacgatt tttggagtgg ttattttgac tactggggcc agggaatcct ggtcaccgtc    420

tcctcagcct ccaccaaggg cccatcggtc ttccccctgg caccctcctc caagaacacc    480

tctgggggca cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg    540

gtgtcctgga actcaggcgc cctg                                           564


<210>  210
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  210

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ala Asp Tyr Asp Phe Trp Ser Gly Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Ile Leu Val Thr Val Ser Ser 
        115                 120         


<210>  211
<211>  519
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  211
atgagggtcc ccgctcagct cctggggctc ctgctgctct ggttcccagg tgccaggtgt     60

gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc    120

atcacttgcc gggcaagtca gggcattaga aatgatttag gctggtatca gcagaaacca    180

gggaaagccc ctaagcgcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca    240

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct    300

gaagattttg caacttatta ctgtctacag cataatagtt acccgtggac gttcggccaa    360

gggaccaagg tggaaatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca    420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat    480

cccagagagg ccaaagtaca gtggaaggtg gataacgcc                           519


<210>  212
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  212

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  213
<211>  432
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  213
tggttcttcc ttctgctggt ggcagctccc agatgggtcc tgtcccaggt gcagctgcag     60

gagtcgggcc caggactggt gaagccttca cagaccctgt ccctcacctg cactgtctct    120

ggtggctcca tcagcagtgg tgattactac tggagctgga tccgccagca cccagggaag    180

ggcctggagt ggattggata catctattac agtgggagca cctactacaa ttcgtccctc    240

aagagtcgag ttaccatatc agtagacacg tctaagaacc agttctccct gaagctgagc    300

tctgtgactg ccgcggacac ggccgtgtat tactgtgcga gagcggatta cgatttttgg    360

agtggttatt ttgactactg gggccaggga accctggtca ccgtctcctc agcctccacc    420

aagggcccat cg                                                        432


<210>  214
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  214

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Ser Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ala Asp Tyr Asp Phe Trp Ser Gly Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  215
<211>  372
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  215
ggtgccaggt gtgacatcca gatgacccag tctccatcct ccctgtctgc atctgtagga     60

gacagagtca ccatcacttg ccgggcaagt cagggcatta gaaatgattt aggctggtat    120

cagcagaaac ctgggaaagc ccctaagcgc ctgatctatg ctgcatccag tttgcaaagt    180

ggggtcccat caaggttcag cggcagtgga tctgggacag aattcactct cacaatcagc    240

agcctgcagc ctgaagattt tgcaacttat tactgtctac agcacaatag ttacccgtgg    300

acgttcggcc aagggaccaa ggtggaaatc aaacgaactg tggctgcacc atctgtcttc    360

atcttcccgc ca                                                        372


<210>  216
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  216

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  217
<211>  548
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  217
aggttcttcc ttctgctggt ggcagctccc agatgggtcc tgtcccaggt gcagctgcag     60

gagtcgggcc caggactggt gaagccttca cagaccctgt ccctcacctg cactgtctct    120

ggtggctcca tcagcagtgg tgattactac tggagctgga tccgccagca cccagggaag    180

ggcctggagt ggattggata catctattac agtgggagca cctactacaa cccgtccctc    240

aagagtcgag ttaccatatc agtagacacg tctaagaacc agttctccct gaagctgagc    300

tctgtgactg ccgcggacac ggccgtgtat tactgtgcga gagccgatta cgatttttgg    360

agtggttatt ttgactactg gggccaggga accctggtca ccgtctcctc agcctccacc    420

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg    480

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca    540

ggcgccct                                                             548


<210>  218
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  218

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ala Asp Tyr Asp Phe Trp Ser Gly Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  219
<211>  517
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  219
atgagggtcc ccgctcagct cctggggctc ctgctgctct ggttcccagg tgccaggtgt     60

gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc    120

atcacttgcc gggcaagtca gggcattaga aatgatttag gctggtatca gcagaaacca    180

gggaaagccc ctaagcgcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca    240

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct    300

gaagattttg caacttatta ctgtctacag cataatagtt acccgtggac gttcggccaa    360

gggaccaagg tggaaatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca    420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat    480

cccagagagg ccaaagtaca gtggaaggtg gataacg                             517


<210>  220
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  220

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  221
<211>  446
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  221
ctgtggttct tccttctgct ggtggcagct cccagatggg tcctgtccca ggtgcagctg     60

caggagtcgg gcccaggact ggtgaagcct tcacagaccc tgtccctcac ctgcactgtc    120

tctggtggct ccatcagcag tggtgattac tactggagct ggatccgcca gcacccaggg    180

aagggcctgg agtggattgg gtacatctat tacagtggga gcacctacta caacccgtcc    240

ctcaagagtc gagttaccat gtcagtagac acgtctaaga accagttctc cctgaagctg    300

agctctgtga ctgccgcgga cacggccgtg tattactgtg cgagagccga ttacgatttt    360

tggagtggtc actttgactg ctggggccag ggaaccctgg tcaccgtctc ctcagcttcc    420

accaagggcc ccatccgtct tccccc                                         446


<210>  222
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  222

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ala Asp Tyr Asp Phe Trp Ser Gly His Phe Asp Cys Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  223
<211>  419
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  223
atgagggtcc ccgctcagct cctggggctc ctgctgctct ggttcccagg tgccaggtgt     60

gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc    120

atcacttgcc gggcaagtca gggcattaga gatgatttag gctggtatca gcagaaacca    180

gggaaagccc ctaagcgcct gatctatgct gaatccagtt tgcaaagtgg ggtcccatca    240

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct    300

gaagattttg caacttatta ctgtctacag catcatagtt acccgtggac gttcggccaa    360

gggaccaagg tggaaatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcc     419


<210>  224
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  224

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asp Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Glu Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His His Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  225
<211>  504
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  225
tggctgagct gggttttcct cgttgctctt ttaagaggtg tccagtgtca ggtgcagctg     60

gtggagtctg ggggaggcgt ggtccagcct gggaggtccc tgagactctc ctgtgcagcg    120

tctggattca ccttcaatag ctatgacatg cactgggtcc gccaggctcc aggcaagggg    180

ctggagtggg tggcagttat atggtatgat ggaagtaata aatactatgc agactccgtg    240

aagggccgat tcaccatctc tagagacaat tccaagaaca cgctgtatct gcaaatgaac    300

agcctgagag ccgaggacac ggctgtgtat tactgtgcga gagaccgctt gtgtactaat    360

ggtgtatgct atgaagacta cggtatggac gtctggggcc aagggaccac ggtcaccgtc    420

tcctcagctt ccaccaaggg cccatccgtc ttccccctgg cgccctgctc caggagcacc    480

tccgagagca cagccgccct gggc                                           504


<210>  226
<211>  126
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  226

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Leu Cys Thr Asn Gly Val Cys Tyr Glu Asp Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  227
<211>  504
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  227
atgagggtcc ctgctcagct cctggggctc ctgctgctct ggctctcagg tgccagatgt     60

gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc    120

atcacttgcc aggcgagtca ggacattagc aactatttaa attggtatca gcagaaacca    180

gggaaagccc ctaaggtcct gatctacgat gcatccaatt tggaaacagg ggtcccatca    240

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct    300

gaagatgttg caacatatta ctgtcaacac tatgatactc tcccgctcac tttcggcgga    360

gggaccaagg tggagatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca    420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat    480

cccagagagg ccaaagtaca gtgg                                           504


<210>  228
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  228

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln His Tyr Asp Thr Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  229
<211>  472
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  229
ggactgtgca agaacatgaa acacctgtgg ttcttcctcc tgctggtggc agctcccaga     60

tgggtcctgt cccaggtgca gctgcaggag tcgggcccag gactggtgaa gcctttacag    120

accctgtccc tcacctgcac tgtctctggt ggctccatca gcagtggtga ttactactgg    180

agctggatcc gccagcaccc agggaagggc ctggagtgga ttgggtacat ctattacagt    240

gggaccacct actacaaccc gtccctcaag agtcgagtta ccatatcagt agacacgtct    300

aagaaccagt tcgccctgaa gctgaactct gtgactgccg cggacacggc cgtgtattac    360

tgtgcgagag ccgattacga tttttggagt ggttattttg actactgggg ccagggaacc    420

ctggtcaccg tctcctcagc ttccaccaag ggcccatccg tcttccccct gg            472


<210>  230
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  230

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Leu Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Thr Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ala Leu Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ala Asp Tyr Asp Phe Trp Ser Gly Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  231
<211>  531
<212>  DNA
<213>  Artificial

<220>
<223>  Antibody

<400>  231
atgagggtcc ctgctcagct cctggggctc ctgctgctct ggttcccagg tgccaggtgt     60

gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc    120

atcacttgcc gggcaggtca gggcattaga aatgatttag gctggtatca gcagaaacca    180

gggaaagccc ctcagcgcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca    240

aggttcagcg gcagtggatc tgggacagaa ttctctctca caatctccag cctgcagcct    300

gaagattttg caacttatta ctgtctacag cataatagtt acccgtggac gttcggccaa    360

gggaccaagg tggaaatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca    420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat    480

cccagagagg ccaaagtaca gtggaaggtg gataacgccc ttccaatcgg g             531


<210>  232
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Antibody

<400>  232

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Gly Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Gln Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  233
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  Primer


<220>
<221>  prim_transcript
<222>  (1)..(26)

<400>  233
cgggatccat gtcctagcct aggggc                                          26


<210>  234
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Primer


<220>
<221>  prim_transcript
<222>  (1)..(39)

<400>  234
gctctagatt aatgatgatg atgatgatgt tgtcctaaa                            39


<210>  235
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-1 CDR-1-h

<400>  235

Gly Gly Ser Ile Asn Ser Gly Asp Tyr Tyr Trp Ser 
1               5                   10          


<210>  236
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-1 CDR-2-h

<400>  236

Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  237
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-1 CDR-3-h

<400>  237

Ala Asp Tyr Asp Phe Trp Ser Gly Tyr Phe Asp Tyr 
1               5                   10          


<210>  238
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  U1-1 CDR-1-l

<400>  238

Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly 
1               5                   10      


<210>  239
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-1 CDR-2-l

<400>  239

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  240
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-1 CDR-3-l

<400>  240

Leu Gln His Asn Ser Tyr Pro Trp Thr 
1               5                   


<210>  241
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 - 2-CDR-1h

<400>  241

Gly Gly Ser Ile Ser Ser Gly Asp Tyr Tyr Trp Ser 
1               5                   10          


<210>  242
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 - 2-CDR-2h

<400>  242

Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Arg Ser 
1               5                   10                  15      


<210>  243
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 - 2-CDR-3h

<400>  243

Ala Asp Tyr Asp Phe Trp Ser Gly Tyr Phe Asp Tyr 
1               5                   10          


<210>  244
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 - 2-CDR-1l

<400>  244

Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly 
1               5                   10      


<210>  245
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 - 2-CDR-2l

<400>  245

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  246
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 - 2-CDR-3l

<400>  246

Leu Gln His Asn Gly Tyr Pro Trp Thr 
1               5                   


<210>  247
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 - 3-CDR-1-h

<400>  247

Gly Gly Ser Ile Ser Ser Gly Gly Tyr Tyr Trp Ser 
1               5                   10          


<210>  248
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 - 3-CDR-2h

<400>  248

Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  249
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 - 3-CDR-3h

<400>  249

Asp Gly Tyr Asp Ser Ser Gly Tyr Tyr His Gly Tyr Phe Asp Tyr 
1               5                   10                  15  


<210>  250
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 - 3-CDR-1l

<400>  250

Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  251
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 - 3-CDR-2l

<400>  251

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  252
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 - 3-CDR-3l

<400>  252

Gln Gln Tyr Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  253
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 - 4-CDR-1h

<400>  253

Gly Gly Ser Ile Ser Ser Gly Asp Tyr Tyr Trp Ser 
1               5                   10          


<210>  254
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 - 4-CDR-2h

<400>  254

Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  255
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 - 4-CDR-3h

<400>  255

Ala Asp Tyr Asp Phe Trp Ser Gly Tyr Phe Asp Tyr 
1               5                   10          


<210>  256
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 - 4-CDR-1l

<400>  256

Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly 
1               5                   10      


<210>  257
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 - 4-CDR-2l

<400>  257

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  258
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 - 4-CDR-3l

<400>  258

Leu Gln His Asn Asn Tyr Pro Trp Thr 
1               5                   


<210>  259
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 - 5-CDR-1h

<400>  259

Gly Gly Ser Ile Ser Ser Gly Asp Tyr Tyr Trp Ser 
1               5                   10          


<210>  260
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 - 5-CDR-2h

<400>  260

Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  261
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 - 5-CDR-3h

<400>  261

Ala Asp Tyr Asp Phe Trp Ser Gly Tyr Phe Asp Tyr 
1               5                   10          


<210>  262
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 - 5-CDR-1l

<400>  262

Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly 
1               5                   10      


<210>  263
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 - 5-CDR-2l

<400>  263

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  264
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 - 5-CDR-3l

<400>  264

Leu Gln His Asn Thr Tyr Pro Trp Thr 
1               5                   


<210>  265
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-6-CDR-1h

<400>  265

Gly Gly Ser Ile Ser Ser Gly Asp Tyr Tyr Trp Ser 
1               5                   10          


<210>  266
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-6-CDR-2h

<400>  266

Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  267
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-6-CDR-3h

<400>  267

Ala Asp Tyr Asp Phe Trp Asn Gly Tyr Phe Asp Tyr 
1               5                   10          


<210>  268
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  U1-6-CDR-1l

<400>  268

Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly 
1               5                   10      


<210>  269
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-6-CDR-2l

<400>  269

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  270
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-6-CDR-3l

<400>  270

Leu Gln His Asn Thr Tyr Pro Trp Thr 
1               5                   


<210>  271
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 - 7-CDR-1h

<400>  271

Gly Gly Ser Ile Ser Ser Gly Asp Tyr Tyr Trp Ser 
1               5                   10          


<210>  272
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 - 7-CDR-2h

<400>  272

Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  273
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 - 7-CDR-3h

<400>  273

Ala Asp Tyr Asp Phe Trp Ser Gly Tyr Phe Asp Tyr 
1               5                   10          


<210>  274
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 - 7-CDR-1l

<400>  274

Arg Ala Ser Gln Asp Ile Arg Asn Asp Leu Gly 
1               5                   10      


<210>  275
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 - 7-CDR-2l

<400>  275

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  276
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 - 7-CDR-3l

<400>  276

Leu Gln His Asn Ser Tyr Pro Trp Thr 
1               5                   


<210>  277
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 - 8-CDR-1h

<400>  277

Gly Tyr Thr Leu Thr Glu Leu Ser Met Tyr 
1               5                   10  


<210>  278
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 - 8-CDR-2h

<400>  278

Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  279
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 - 8-CDR-3h

<400>  279

Gly Trp Asn Tyr Val Phe Asp Tyr 
1               5               


<210>  280
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 - 8-CDR-1l

<400>  280

Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp 
1               5                   10                  15      


<210>  281
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 - 8-CDR-2l

<400>  281

Leu Asp Ser His Arg Ala Ser 
1               5           


<210>  282
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 - 8-CDR-3l

<400>  282

Met Gln Ala Leu Gln Thr Pro Leu Thr 
1               5                   


<210>  283
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 - 9-CDR-1h

<400>  283

Gly Gly Ser Ile Ser Ser Gly Asp Tyr Tyr Trp Ser 
1               5                   10          


<210>  284
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 - 9-CDR-2h

<400>  284

Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  285
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 - 9-CDR-3h

<400>  285

Ala Asp Tyr Asp Phe Trp Asn Gly Tyr Phe Asp Tyr 
1               5                   10          


<210>  286
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 - 9-CDR-1l

<400>  286

Arg Ala Ser Gln Asp Ile Arg Asn Asp Leu Gly 
1               5                   10      


<210>  287
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 - 9-CDR-2l

<400>  287

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  288
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 - 9-CDR-3l

<400>  288

Leu Gln His Asn Ser Tyr Pro Trp Thr 
1               5                   


<210>  289
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-10-CDR-1h

<400>  289

Gly Gly Ser Ile Ser Ser Gly Asp Tyr Tyr Trp Ser 
1               5                   10          


<210>  290
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-10-CDR-2h

<400>  290

Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  291
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-10-CDR-3h

<400>  291

Ala Asp Tyr Asp Phe Trp Ser Gly Tyr Phe Asp Tyr 
1               5                   10          


<210>  292
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  U1-10-CDR-1l

<400>  292

Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly 
1               5                   10      


<210>  293
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-10-CDR-2l

<400>  293

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  294
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-10-CDR-3l

<400>  294

Leu Gln His Asn Asn Tyr Pro Trp Thr 
1               5                   


<210>  295
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 -11-CDR-1h

<400>  295

Gly Gly Ser Ile Ser Ser Gly Asp Tyr Tyr Trp Ser 
1               5                   10          


<210>  296
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 -11-CDR-2h

<400>  296

Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  297
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 -11-CDR-3h

<400>  297

Ala Asp Tyr Asp Phe Trp Ser Gly Tyr Phe Asp Tyr 
1               5                   10          


<210>  298
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 -11-CDR-1l

<400>  298

Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly 
1               5                   10      


<210>  299
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 -11-CDR-2l

<400>  299

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  300
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 -11-CDR-3l

<400>  300

Leu Gln His Asn Thr Tyr Pro Trp Thr 
1               5                   


<210>  301
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 - 12-CDR-1h

<400>  301

Gly Gly Ser Ile Ser Ser Gly Asp Tyr Tyr Trp Ser 
1               5                   10          


<210>  302
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 - 12-CDR-2h

<400>  302

Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  303
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-12-CDR-3h

<400>  303

Ala Asp Tyr Asp Phe Trp Ser Gly Tyr Phe Asp Tyr 
1               5                   10          


<210>  304
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  U1-12-CDR-1l

<400>  304

Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly 
1               5                   10      


<210>  305
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-12-CDR-2l

<400>  305

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  306
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-12-CDR-3l

<400>  306

Leu Gln His Asn Asn Tyr Pro Trp Thr 
1               5                   


<210>  307
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 -13-CDR-1h

<400>  307

Gly Gly Ser Ile Ser Ser Gly Gly Tyr Tyr Trp Ser 
1               5                   10          


<210>  308
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 -13-CDR-2h

<400>  308

Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  309
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 -13-CDR-3h

<400>  309

Glu Asp Asp Gly Met Asp Val 
1               5           


<210>  310
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 -13-CDR-1l

<400>  310

Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Glu 
1               5                   10                  15      


<210>  311
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 -13-CDR-2l

<400>  311

Leu Gly Ser Asn Arg Ala Ser 
1               5           


<210>  312
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U 1 -13-CDR-3l

<400>  312

Met Gln Ala Leu Gln Thr Pro Ile Thr 
1               5                   


<210>  313
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-14-CDR-1h

<400>  313

Gly Gly Ser Ile Ser Ser Gly Asp Tyr Tyr Trp Ser 
1               5                   10          


<210>  314
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-14-CDR-2h

<400>  314

Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  315
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-14-CDR-3h

<400>  315

Ala Asp Tyr Asp Phe Trp Ser Gly Tyr Phe Asp Tyr 
1               5                   10          


<210>  316
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  U1-14-CDR-1l

<400>  316

Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly 
1               5                   10      


<210>  317
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-14-CDR-2l

<400>  317

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  318
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-14-CDR-3l

<400>  318

Leu Gln His Asn Thr Tyr Pro Trp Thr 
1               5                   


<210>  319
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-15-CDR-1h

<400>  319

Gly Gly Ser Val Ser Ser Gly Gly Tyr Tyr Trp Ser 
1               5                   10          


<210>  320
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-15-CDR-2h

<400>  320

Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  321
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  U1-15-CDR-3h

<400>  321

Asp Gly Asp Val Asp Thr Ala Met Val Asp Ala Phe Asp Ile 
1               5                   10                  


<210>  322
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-15-CDR-1l

<400>  322

Arg Ala Ser Gln Ser Leu Ser Gly Asn Tyr Leu Ala 
1               5                   10          


<210>  323
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-15-CDR-2l

<400>  323

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  324
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-15-CDR-3l

<400>  324

Gln Gln Tyr Asp Arg Ser Pro Leu Thr 
1               5                   


<210>  325
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-16-CDR-1h

<400>  325

Gly Gly Ser Ile Ser Ser Gly Asp Tyr Tyr Trp Ser 
1               5                   10          


<210>  326
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-16-CDR-2h

<400>  326

Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  327
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-16-CDR-3h

<400>  327

Ala Asp Tyr Asp Phe Trp Ser Gly Tyr Phe Asp Tyr 
1               5                   10          


<210>  328
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  U1-16-CDR-1l

<400>  328

Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly 
1               5                   10      


<210>  329
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-16-CDR-2l

<400>  329

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  330
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-16-CDR-3l

<400>  330

Leu Gln His Asn Ser Tyr Pro Trp Thr 
1               5                   


<210>  331
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-17-CDR-1h

<400>  331

Gly Gly Ser Ile Ser Ser Gly Asp Tyr Tyr Trp Ser 
1               5                   10          


<210>  332
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-17-CDR-2h

<400>  332

Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Ser Ser Leu Lys Ser 
1               5                   10                  15      


<210>  333
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-17-CDR-3h

<400>  333

Ala Asp Tyr Asp Phe Trp Ser Gly Tyr Phe Asp Tyr 
1               5                   10          


<210>  334
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  U1-17-CDR-1l

<400>  334

Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly 
1               5                   10      


<210>  335
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-17-CDR-2l

<400>  335

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  336
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-17-CDR-3l

<400>  336

Leu Gln His Asn Ser Tyr Pro Trp Thr 
1               5                   


<210>  337
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-18-CDR-1h

<400>  337

Gly Gly Ser Ile Ser Ser Gly Asp Tyr Tyr Trp Ser 
1               5                   10          


<210>  338
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-18-CDR-2h

<400>  338

Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  339
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-18-CDR-3h

<400>  339

Ala Asp Tyr Asp Phe Trp Ser Gly Tyr Phe Asp Tyr 
1               5                   10          


<210>  340
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  U1-18-CDR-1l

<400>  340

Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly 
1               5                   10      


<210>  341
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-18-CDR-2l

<400>  341

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  342
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-18-CDR-3l

<400>  342

Leu Gln His Asn Ser Tyr Pro Trp Thr 
1               5                   


<210>  343
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-19-CDR-1h

<400>  343

Gly Gly Ser Ile Ser Ser Gly Asp Tyr Tyr Trp Ser 
1               5                   10          


<210>  344
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-19-CDR-2h

<400>  344

Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  345
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-19-CDR-3h

<400>  345

Gly Asp Tyr Asp Phe Trp Ser Gly Glu Phe Asp Tyr 
1               5                   10          


<210>  346
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-20-CDR-1h

<400>  346

Gly Gly Ser Ile Ser Ser Gly Gly Tyr Tyr Trp Ser 
1               5                   10          


<210>  347
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-20-CDR-2h

<400>  347

Tyr Ile Tyr Asp Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  348
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  U1-20-CDR-3h

<400>  348

Asp Gln Gly Gln Asp Gly Tyr Ser Tyr Gly Tyr Gly Tyr Tyr Tyr Gly 
1               5                   10                  15      


Met Asp Val 
            


<210>  349
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  U1-20-CDR-1l

<400>  349

Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  350
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-20-CDR-2l

<400>  350

Val Ala Ser Asn Leu Glu Thr 
1               5           


<210>  351
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-20-CDR-3l

<400>  351

Gln Gln Cys Asp Asn Leu Pro Leu Thr 
1               5                   


<210>  352
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-21-CDR-1h

<400>  352

Gly Gly Ser Ile Ser Ser Gly Asp Tyr Tyr Trp Ser 
1               5                   10          


<210>  353
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-21-CDR-2h

<400>  353

Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  354
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-21-CDR-3h

<400>  354

Ala Asp Tyr Asp Phe Trp Ser Gly Tyr Phe Asp Tyr 
1               5                   10          


<210>  355
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  U1-21-CDR-1l

<400>  355

Arg Ala Ser Gln Asp Ile Arg Asn Asp Leu Gly 
1               5                   10      


<210>  356
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-21-CDR-2l

<400>  356

Ala Ala Ser Arg Leu Gln Ser 
1               5           


<210>  357
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-21-CDR-3l

<400>  357

Leu Gln His Asn Ser Tyr Pro Trp Thr 
1               5                   


<210>  358
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-22-CDR-1h

<400>  358

Gly Gly Ser Ile Ser Ser Gly Asp Tyr Tyr Trp Ser 
1               5                   10          


<210>  359
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-22-CDR-2h

<400>  359

Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  360
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-22-CDR-3h

<400>  360

Ala Asp Tyr Asp Phe Trp Ser Gly Tyr Phe Asp Tyr 
1               5                   10          


<210>  361
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  U1-22-CDR-1l

<400>  361

Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly 
1               5                   10      


<210>  362
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-22-CDR-2l

<400>  362

Ala Ala Ser Ser Leu Gln Asn 
1               5           


<210>  363
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-22-CDR-3l

<400>  363

Leu Gln His Asn Ser Tyr Pro Trp Thr 
1               5                   


<210>  364
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-23-CDR-1h

<400>  364

Gly Gly Ser Ile Ser Ser Gly Asp Tyr Tyr Trp Ser 
1               5                   10          


<210>  365
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-23-CDR-2h

<400>  365

Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  366
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-23-CDR-3h

<400>  366

Ala Asp Tyr Asp Phe Trp Ser Gly Tyr Phe Asp Tyr 
1               5                   10          


<210>  367
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  U1-23-CDR-1l

<400>  367

Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly 
1               5                   10      


<210>  368
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-23-CDR-2l

<400>  368

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  369
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-23-CDR-3l

<400>  369

Leu Gln His Asn Ser Tyr Pro Trp Thr 
1               5                   


<210>  370
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-24-CDR-1h

<400>  370

Gly Gly Ser Ile Ser Ser Gly Asp Tyr Tyr Trp Ser 
1               5                   10          


<210>  371
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-24-CDR-2h

<400>  371

Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  372
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-24-CDR-3h

<400>  372

Ala Asp Tyr Asp Phe Trp Asn Gly Tyr Phe Asp Tyr 
1               5                   10          


<210>  373
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  U1-24-CDR-1l

<400>  373

Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly 
1               5                   10      


<210>  374
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-24-CDR-2l

<400>  374

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  375
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-24-CDR-3l

<400>  375

Leu Gln His Asn Asn Tyr Pro Trp Thr 
1               5                   


<210>  376
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-25-CDR-1h

<400>  376

Gly Gly Ser Ile Ser Ser Gly Asp Tyr Tyr Trp Ser 
1               5                   10          


<210>  377
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-25-CDR-2h

<400>  377

Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  378
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-25-CDR-3h

<400>  378

Ala Asp Tyr Asp Phe Trp Ser Gly Tyr Phe Asp Tyr 
1               5                   10          


<210>  379
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  U1-25-CDR-1l

<400>  379

Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly 
1               5                   10      


<210>  380
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-25-CDR-2l

<400>  380

Ala Ala Ser Ser Leu Gln Asn 
1               5           


<210>  381
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-25-CDR-3l

<400>  381

Leu Gln His Asn Ser Tyr Pro Trp Thr 
1               5                   


<210>  382
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-26-CDR-1h

<400>  382

Gly Gly Ser Ile Ser Ser Gly Asp Tyr Tyr Trp Ser 
1               5                   10          


<210>  383
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-26-CDR-2h

<400>  383

Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  384
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-26-CDR-3h

<400>  384

Ala Asp Tyr Asp Phe Trp Ser Gly Tyr Phe Asp Phe 
1               5                   10          


<210>  385
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  U1-26-CDR-1l

<400>  385

Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly 
1               5                   10      


<210>  386
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-26-CDR-2l

<400>  386

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  387
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-26-CDR-3l

<400>  387

Leu Gln His Asn Gly Tyr Pro Trp Thr 
1               5                   


<210>  388
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-27-CDR-1h

<400>  388

Gly Gly Ser Ile Ser Ser Gly Asp Tyr Tyr Trp Ser 
1               5                   10          


<210>  389
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-27-CDR-2h

<400>  389

Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  390
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-27-CDR-3h

<400>  390

Ala Asp Tyr Asp Phe Trp Ser Gly Tyr Phe Asp Phe 
1               5                   10          


<210>  391
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  U1-27-CDR-1l

<400>  391

Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly 
1               5                   10      


<210>  392
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-27-CDR-2l

<400>  392

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  393
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-27-CDR-3l

<400>  393

Leu Gln His Asn Gly Tyr Pro Trp Thr 
1               5                   


<210>  394
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-28-CDR-1h

<400>  394

Gly Gly Ser Ile Ser Ser Gly Asp Tyr Tyr Trp Ser 
1               5                   10          


<210>  395
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-28-CDR-2h

<400>  395

Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  396
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-28-CDR-1l

<400>  396

Ala Asp Tyr Asp Phe Trp Ser Gly Tyr Phe Asp Ser 
1               5                   10          


<210>  397
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  U1-28-CDR-1l

<400>  397

Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly 
1               5                   10      


<210>  398
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-28-CDR-2l

<400>  398

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  399
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-28-CDR-3l

<400>  399

Leu Gln His Asn Gly Tyr Pro Trp Thr 
1               5                   


<210>  400
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  U1-29-CDR-1h

<400>  400

Gly Phe Thr Phe Asn Ser Tyr Asp Met His 
1               5                   10  


<210>  401
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  U1-29-CDR-2h

<400>  401

Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  402
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  U1-29-CDR-3h

<400>  402

Asp Arg Leu Cys Thr Asn Gly Val Cys Tyr Glu Asp Tyr Gly Met Asp 
1               5                   10                  15      


Val 
    


<210>  403
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  U1-29-CDR-1l

<400>  403

Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  404
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-29-CDR-2l

<400>  404

Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  405
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-29-CDR-3l

<400>  405

Gln His Tyr Asp Thr Leu Pro Leu Thr 
1               5                   


<210>  406
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-30-CDR-1h

<400>  406

Gly Gly Ser Ile Ser Ser Gly Asp Tyr Tyr Trp Ser 
1               5                   10          


<210>  407
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-30-CDR-2h

<400>  407

Tyr Ile Tyr Tyr Ser Gly Thr Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  408
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-30-CDR-3h

<400>  408

Ala Asp Tyr Asp Phe Trp Ser Gly Tyr Phe Asp Tyr 
1               5                   10          


<210>  409
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  U1-30-CDR-1l

<400>  409

Arg Ala Gly Gln Gly Ile Arg Asn Asp Leu Gly 
1               5                   10      


<210>  410
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-30-CDR-2l

<400>  410

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  411
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-30-CDR-3l

<400>  411

Leu Gln His Asn Ser Tyr Pro Trp Thr 
1               5                   


<210>  412
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  U1-31-CDR-1h

<400>  412

Gly Tyr Thr Phe Thr Asn Tyr Gly Ile Ser 
1               5                   10  


<210>  413
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  U1-31-CDR-2h

<400>  413

Trp Ile Ser Ala Tyr Asp Gly Tyr Arg Asn Tyr Ala Gln Lys Leu Gln 
1               5                   10                  15      


Gly 
    


<210>  414
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  U1-31-CDR-3h

<400>  414

Asp Val Gln Asp Tyr Gly Asp Tyr Asp Tyr Phe Asp Tyr 
1               5                   10              


<210>  415
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  U1-31-CDR-1l

<400>  415

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  416
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-31-CDR-2l

<400>  416

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  417
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-31-CDR-3l

<400>  417

Gln Gln Ser Tyr Ser Thr Pro Ile Thr 
1               5                   


<210>  418
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-32-CDR-1h

<400>  418

Gly Gly Ser Ile Ser Ser Gly Asp Tyr Tyr Trp Ser 
1               5                   10          


<210>  419
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-32-CDR-2h

<400>  419

Tyr Ile Tyr Tyr Ser Gly Thr Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  420
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-32-CDR-3h

<400>  420

Ala Asp Tyr Asp Phe Trp Ser Gly Tyr Phe Asp Tyr 
1               5                   10          


<210>  421
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  U1-32-CDR-1l

<400>  421

Arg Ala Gly Gln Gly Ile Arg Asn Asp Leu Gly 
1               5                   10      


<210>  422
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-32-CDR-2l

<400>  422

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  423
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-32-CDR-3l

<400>  423

Leu Gln His Asn Ser Tyr Pro Trp Thr 
1               5                   


<210>  424
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-33-CDR-1h

<400>  424

Gly Gly Ser Ile Ser Ser Gly Asp Tyr Tyr Trp Ser 
1               5                   10          


<210>  425
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-33-CDR-2h

<400>  425

Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  426
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-33-CDR-3h

<400>  426

Ala Asp Tyr Asp Phe Trp Ser Gly His Phe Asp Cys 
1               5                   10          


<210>  427
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  U1-33-CDR-1l

<400>  427

Arg Ala Ser Gln Gly Ile Arg Asp Asp Leu Gly 
1               5                   10      


<210>  428
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-33-CDR-2l

<400>  428

Ala Glu Ser Ser Leu Gln Ser 
1               5           


<210>  429
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-33-CDR-3l

<400>  429

Leu Gln His His Ser Tyr Pro Trp Thr 
1               5                   


<210>  430
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  U1-34-CDR-1h

<400>  430

Gly Tyr Thr Phe Thr Asn Tyr Gly Ile Ser 
1               5                   10  


<210>  431
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  U1-34-CDR-2h

<400>  431

Trp Ile Ser Ala Tyr Asp Gly Tyr Arg Asn Tyr Ala Gln Lys Leu Gln 
1               5                   10                  15      


Gly 
    


<210>  432
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  U1-34-CDR-3h

<400>  432

Asp Val Gln Asp Tyr Gly Asp Tyr Asp Tyr Phe Asp Tyr 
1               5                   10              


<210>  433
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  U1-34-CDR-1l

<400>  433

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  434
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-34-CDR-2l

<400>  434

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  435
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-34-CDR-3l

<400>  435

Gln Gln Ser Tyr Ser Thr Pro Ile Thr 
1               5                   


<210>  436
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  U1-35-CDR-1h

<400>  436

Gly Phe Thr Phe Ser Asp Tyr Tyr Met Ser 
1               5                   10  


<210>  437
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  U1-35-CDR-2h

<400>  437

Tyr Ile Ser Ser Ser Gly Asn Asn Ile Tyr His Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  438
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  U1-35-CDR-3h

<400>  438

Glu Arg Tyr Ser Gly Tyr Asp Asp Pro Asp Gly Phe Asp Ile 
1               5                   10                  


<210>  439
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  U1-35-CDR-1l

<400>  439

Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Ser 
1               5                   10      


<210>  440
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-35-CDR-2l

<400>  440

Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  441
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-35-CDR-3l

<400>  441

Gln Gln Tyr Asp Asn Pro Pro Cys Ser 
1               5                   


<210>  442
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-36-CDR-1h

<400>  442

Gly Gly Ser Ile Ser Ser Gly Tyr Tyr Tyr Trp Ser 
1               5                   10          


<210>  443
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-36-CDR-2h

<400>  443

Tyr Ile Tyr Tyr Ser Gly Thr Thr Tyr Tyr Asn Pro Ser Phe Lys Ser 
1               5                   10                  15      


<210>  444
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-36-CDR-3h

<400>  444

Ala Asp Tyr Asp Phe Trp Ser Gly His Phe Asp Tyr 
1               5                   10          


<210>  445
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  U1-36-CDR-1l

<400>  445

Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly 
1               5                   10      


<210>  446
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-36-CDR-2l

<400>  446

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  447
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-36-CDR-3l

<400>  447

Leu Gln His Asn Ser Tyr Pro Trp Thr 
1               5                   


<210>  448
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  U1-37-CDR-1h

<400>  448

Gly Tyr Thr Phe Thr Ser Tyr Gly Ile Ser 
1               5                   10  


<210>  449
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  U1-37-CDR-2h

<400>  449

Trp Ile Ser Ala Tyr Asp Gly His Thr Asn Tyr Ala Gln Lys Leu Gln 
1               5                   10                  15      


Gly 
    


<210>  450
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  U1-37-CDR-3h

<400>  450

Asp Pro His Asp Tyr Ser Asn Tyr Glu Ala Phe Asp Phe 
1               5                   10              


<210>  451
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  U1-37-CDR-1l

<400>  451

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  452
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-37-CDR-2l

<400>  452

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  453
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-37-CDR-3l

<400>  453

Gln Gln Ser Tyr Ser Thr Pro Ile Thr 
1               5                   


<210>  454
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-38-CDR-1h

<400>  454

Gly Phe Ser Leu Ser Thr Ser Gly Val Gly Val Gly 
1               5                   10          


<210>  455
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-38-CDR-2h

<400>  455

Leu Ile Tyr Trp Asn Asp Asp Lys Arg Tyr Ser Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  456
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-38-CDR-3h

<400>  456

Arg Asp Glu Val Arg Gly Phe Asp Tyr 
1               5                   


<210>  457
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-38-CDR-1l

<400>  457

Arg Ser Ser Gln Ser Leu Val Tyr Ser Asp Gly Tyr Thr Tyr Leu His 
1               5                   10                  15      


<210>  458
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-38-CDR-2l

<400>  458

Lys Val Ser Asn Trp Asp Ser 
1               5           


<210>  459
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-38-CDR-3l

<400>  459

Met Gln Gly Ala His Trp Pro Ile Thr 
1               5                   


<210>  460
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  U1-39-CDR-1h

<400>  460

Gly Phe Thr Val Ser Ser Asn Tyr Met Ser 
1               5                   10  


<210>  461
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-39-CDR-2h

<400>  461

Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  462
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  U1-39-CDR-3h

<400>  462

Gly Gln Trp Leu Asp Val 
1               5       


<210>  463
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-39-CDR-1l

<400>  463

Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp 
1               5                   10                  15      


<210>  464
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-39-CDR-2l

<400>  464

Leu Gly Phe His Arg Ala Ser 
1               5           


<210>  465
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-39-CDR-3l

<400>  465

Arg Gln Ala Leu Gln Thr Pro Leu Thr 
1               5                   


<210>  466
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-40-CDR-1h

<400>  466

Gly Gly Ser Ile Ser Ser Gly Gly Tyr Tyr Trp Ser 
1               5                   10          


<210>  467
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-40-CDR-2h

<400>  467

Tyr Ile Tyr Ser Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  468
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  U1-40-CDR-3h

<400>  468

Asp Arg Glu Leu Glu Leu Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15  


<210>  469
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-40-CDR-1l

<400>  469

Arg Ser Ser Gln Ser Leu Leu Tyr Ser Asn Gly Tyr Asn Tyr Leu Asp 
1               5                   10                  15      


<210>  470
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-40-CDR-2l

<400>  470

Leu Gly Ser Asn Arg Ala Ser 
1               5           


<210>  471
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-40-CDR-3l

<400>  471

Met Gln Ala Leu Gln Thr Pro Leu Thr 
1               5                   


<210>  472
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-41-CDR-1h

<400>  472

Gly Gly Ser Ile Ser Ser Gly Gly Tyr Tyr Trp Ser 
1               5                   10          


<210>  473
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-41-CDR-2h

<400>  473

Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  474
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  U1-41-CDR-3h

<400>  474

Asp Arg Glu Leu Glu Gly Tyr Ser Asn Tyr Tyr Gly Val Asp Val 
1               5                   10                  15  


<210>  475
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  U1-41-CDR-1l

<400>  475

Arg Ala Ser Gln Ala Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  476
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-41-CDR-2l

<400>  476

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  477
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-41-CDR-3l

<400>  477

Gln Gln Asn Asn Ser Leu Pro Ile Thr 
1               5                   


<210>  478
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  U1-42-CDR-1h

<400>  478

Gly Tyr Ser Phe Thr Ser Tyr Trp Ile Gly 
1               5                   10  


<210>  479
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  U1-42-CDR-2h

<400>  479

Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  480
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-42-CDR-3h

<400>  480

His Glu Asn Tyr Gly Asp Tyr Asn Tyr 
1               5                   


<210>  481
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  U1-42-CDR-1l

<400>  481

Arg Ala Ser Gln Ser Ile Arg Ser Tyr Leu Asn 
1               5                   10      


<210>  482
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-42-CDR-2l

<400>  482

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  483
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-42-CDR-3l

<400>  483

Gln Gln Ser Asn Gly Ser Pro Leu Thr 
1               5                   


<210>  484
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-43-CDR-1h

<400>  484

Gly Gly Ser Ile Ser Ser Gly Gly Tyr Tyr Trp Ser 
1               5                   10          


<210>  485
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-43-CDR-2h

<400>  485

Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Arg Ser 
1               5                   10                  15      


<210>  486
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  U1-43-CDR-3h

<400>  486

Asp Arg Glu Arg Glu Trp Asp Asp Tyr Gly Asp Pro Gln Gly Met Asp 
1               5                   10                  15      


Val 
    


<210>  487
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  U1-43-CDR-1l

<400>  487

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu His 
1               5                   10      


<210>  488
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-43-CDR-2l

<400>  488

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  489
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-43-CDR-3l

<400>  489

Gln Gln Ser Tyr Ser Asn Pro Leu Thr 
1               5                   


<210>  490
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  U1-44-CDR-1h

<400>  490

Gly Tyr Ser Phe Thr Ser Tyr Trp Ile Gly 
1               5                   10  


<210>  491
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  U1-44-CDR-2h

<400>  491

Ile Ile Trp Pro Gly Asp Ser Asp Thr Ile Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  492
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-44-CDR-3h

<400>  492

His Glu Asn Tyr Gly Asp Tyr Asn Tyr 
1               5                   


<210>  493
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  U1-44-CDR-1l

<400>  493

Arg Ala Ser Gln Ser Ile Arg Ser Tyr Leu Asn 
1               5                   10      


<210>  494
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-44-CDR-2l

<400>  494

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  495
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-44-CDR-3l

<400>  495

Gln Gln Ser Ile Ser Ser Pro Leu Thr 
1               5                   


<210>  496
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  U1-45-CDR-1h

<400>  496

Gly Tyr Thr Phe Thr Ser Tyr Asp Ile Asn 
1               5                   10  


<210>  497
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  U1-45-CDR-2h

<400>  497

Trp Met Asn Pro Asn Ser Gly Asp Thr Gly Tyr Ala Gln Val Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  498
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-45-CDR-3h

<400>  498

Phe Gly Asp Leu Pro Tyr Asp Tyr Ser Tyr Tyr Glu Trp Phe Asp Pro 
1               5                   10                  15      


<210>  499
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  U1-45-CDR-1l

<400>  499

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  500
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-45-CDR-2l

<400>  500

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  501
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-45-CDR-3l

<400>  501

Gln Gln Ser Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  502
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-46-CDR-1h

<400>  502

Gly Asp Ser Val Ser Ser Asn Ser Ala Ala Trp Asn 
1               5                   10          


<210>  503
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  U1-46-CDR-2h

<400>  503

Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala Val Ser Val 
1               5                   10                  15      


Lys Ser 
        


<210>  504
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  U1-46-CDR-3h

<400>  504

Asp Leu Tyr Asp Phe Trp Ser Gly Tyr Pro Tyr Tyr Tyr Gly Met Asp 
1               5                   10                  15      


Val 
    


<210>  505
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-47-CDR-1h

<400>  505

Gly Asp Ser Val Ser Ser Asn Ser Ala Ala Trp Asn 
1               5                   10          


<210>  506
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  U1-47-CDR-2h

<400>  506

Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala Val Ser Val 
1               5                   10                  15      


Lys Ser 
        


<210>  507
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-47-CDR-3h

<400>  507

Asp Tyr Tyr Gly Ser Gly Ser Phe Tyr Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15      


<210>  508
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  U1-47-CDR-1l

<400>  508

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  509
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-47-CDR-2l

<400>  509

Ala Ala Ser Asn Leu Gln Ser 
1               5           


<210>  510
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-47-CDR-3l

<400>  510

Gln Gln Ser Tyr Ser Thr Pro Arg Thr 
1               5                   


<210>  511
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  U1-48-CDR-1h

<400>  511

Gly Gly Ser Ile Ser Ser Tyr Tyr Trp Ser 
1               5                   10  


<210>  512
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-48-CDR-2h

<400>  512

His Ile Tyr Thr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  513
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-48-CDR-3h

<400>  513

Glu Ala Ile Phe Gly Val Gly Pro Tyr Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15      


<210>  514
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  U1-49-CDR-1h

<400>  514

Gly Tyr Thr Phe Thr Gly Tyr Tyr Met His 
1               5                   10  


<210>  515
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  U1-49-CDR-2h

<400>  515

Trp Ile Asn Pro Asn Ile Gly Gly Thr Asn Cys Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  516
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  U1-49-CDR-3h

<400>  516

Gly Gly Arg Tyr Ser Ser Ser Trp Ser Tyr Tyr Tyr Tyr Gly Met Asp 
1               5                   10                  15      


Val 
    


<210>  517
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-49-CDR-1l

<400>  517

Lys Ser Ser Gln Ser Leu Leu Leu Ser Asp Gly Gly Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  518
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-49-CDR-2l

<400>  518

Glu Val Ser Asn Arg Phe Ser 
1               5           


<210>  519
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-49-CDR-3l

<400>  519

Met Gln Ser Met Gln Leu Pro Ile Thr 
1               5                   


<210>  520
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-50-CDR-1h

<400>  520

Gly Gly Ser Val Ser Ser Gly Gly Tyr Tyr Trp Ser 
1               5                   10          


<210>  521
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-50-CDR-2h

<400>  521

Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  522
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  U1-50-CDR-3h

<400>  522

Gly Gly Asp Ser Asn Tyr Glu Asp Tyr Tyr Tyr Tyr Tyr Gly Met Asp 
1               5                   10                  15      


Val 
    


<210>  523
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  U1-50-CDR-1l

<400>  523

Arg Ala Ser Gln Ser Ile Ser Ile Tyr Leu His 
1               5                   10      


<210>  524
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-50-CDR-2l

<400>  524

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  525
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-50-CDR-3l

<400>  525

Gln Gln Ser Tyr Thr Ser Pro Ile Thr 
1               5                   


<210>  526
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  U1-51-CDR-1h

<400>  526

Gly Gly Ser Ile Ser Ser Tyr Tyr Trp Ser 
1               5                   10  


<210>  527
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-51-CDR-2h

<400>  527

Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  528
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  U1-51-CDR-3h

<400>  528

Asp Ser Ser Tyr Tyr Asp Ser Ser Gly Tyr Tyr Leu Tyr Tyr Tyr Ala 
1               5                   10                  15      


Met Asp Val 
            


<210>  529
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  U1-51-CDR-1l

<400>  529

Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  530
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-51-CDR-2l

<400>  530

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  531
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-51-CDR-3l

<400>  531

Gln Gln Tyr Tyr Thr Thr Pro Leu Thr 
1               5                   


<210>  532
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-52-CDR-1h

<400>  532

Gly Gly Ser Ile Ser Ser Gly Gly Tyr Tyr Trp Ser 
1               5                   10          


<210>  533
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-52-CDR-2h

<400>  533

Asn Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  534
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  U1-52-CDR-3h

<400>  534

Gly Gly Thr Gly Thr Asn Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15  


<210>  535
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-52-CDR-1l

<400>  535

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  536
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-52-CDR-2l

<400>  536

Gly Ala Ser Ser Trp Ala Thr 
1               5           


<210>  537
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-52-CDR-3l

<400>  537

Gln Gln Tyr Gly Ser Ser Pro Leu Thr 
1               5                   


<210>  538
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  U1-53-CDR-1h

<400>  538

Gly Phe Thr Phe Ser Ile Tyr Ser Met Asn 
1               5                   10  


<210>  539
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  U1-53-CDR-2h

<400>  539

Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  540
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  U1-53-CDR-3h

<400>  540

Asp Arg Gly Asp Phe Asp Ala Phe Asp Ile 
1               5                   10  


<210>  541
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  U1-53-CDR-1l

<400>  541

Gln Ala Ser Gln Asp Ile Thr Asn Tyr Leu Asn 
1               5                   10      


<210>  542
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-53-CDR-2l

<400>  542

Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  543
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-53-CDR-3l

<400>  543

Gln Gln Cys Glu Asn Phe Pro Ile Thr 
1               5                   


<210>  544
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-55.1-CDR-1h

<400>  544

Gly Gly Ser Val Ser Ser Gly Gly Tyr Tyr Trp Asn 
1               5                   10          


<210>  545
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-55.1-CDR-2h

<400>  545

Tyr Ile Asn Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  546
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  U1-55.1-CDR-3h

<400>  546

Asp Arg Glu Leu Glu Leu Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15  


<210>  547
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-55-CDR-1l

<400>  547

Arg Ser Ser Gln Ser Leu Leu Tyr Ser Asn Gly Tyr Lys Tyr Leu Asp 
1               5                   10                  15      


<210>  548
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-55-CDR-2l

<400>  548

Leu Gly Ser Asn Arg Ala Ser 
1               5           


<210>  549
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-55-CDR-3l

<400>  549

Met Gln Ala Leu Gln Thr Pro Ile Thr 
1               5                   


<210>  550
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-57.1-CDR-1l

<400>  550

Arg Ser Ser Gln Ser Leu Leu Tyr Ser Asn Gly Tyr Lys Tyr Leu Asp 
1               5                   10                  15      


<210>  551
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-57.1-CDR-2l

<400>  551

Leu Gly Ser Asn Arg Ala Ser 
1               5           


<210>  552
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-57.1-CDR-3l

<400>  552

Met Gln Ala Leu Gln Thr Pro Ile Thr 
1               5                   


<210>  553
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-57_CDR-1h

<400>  553

Gly Gly Ser Val Ser Ser Gly Gly Tyr Tyr Trp Asn 
1               5                   10          


<210>  554
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-57_CDR-2h

<400>  554

Tyr Ile Asn Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  555
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  U1-57_CDR-3h

<400>  555

Asp Arg Glu Leu Glu Leu Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15  


<210>  556
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  U1-58-CDR-1h

<400>  556

Gly Phe Thr Phe Ser Ser Tyr Gly Met His 
1               5                   10  


<210>  557
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  U1-58-CDR-2h

<400>  557

Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  558
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-58-CDR-3h

<400>  558

Ala Ala Arg Leu Asp Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10          


<210>  559
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  U1-58-CDR-1l

<400>  559

Arg Ala Ser Gln Ser Ile Asn Ser Tyr Leu Asn 
1               5                   10      


<210>  560
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-58-CDR-2l

<400>  560

Gly Ala Ser Gly Leu Gln Ser 
1               5           


<210>  561
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-58-CDR-3l

<400>  561

Gln Gln Ser Tyr Ser Ser Pro Leu Thr 
1               5                   


<210>  562
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  U1-59-CDR-1h

<400>  562

Gly Gly Ser Phe Ser Gly Tyr Tyr Trp Ser 
1               5                   10  


<210>  563
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-59-CDR-2h

<400>  563

Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  564
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-59-CDR-3h

<400>  564

Asp Lys Trp Thr Trp Tyr Phe Asp Leu 
1               5                   


<210>  565
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  U1-59-CDR-1l

<400>  565

Arg Ser Ser Gln Ser Val Leu Tyr Ser Ser Ser Asn Arg Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  566
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-59-CDR-2l

<400>  566

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  567
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-59-CDR-3l

<400>  567

Gln Gln Tyr Tyr Ser Thr Pro Arg Thr 
1               5                   


<210>  568
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-61.1-CDR-1h

<400>  568

Gly Val Ser Ile Ser Ser Gly Gly Tyr Tyr Trp Ser 
1               5                   10          


<210>  569
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-61.1-CDR-2h

<400>  569

Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  570
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-61.1-CDR-3h

<400>  570

Asp Ser Glu Ser Glu Tyr Ser Ser Ser Ser Asn Tyr Gly Met Asp Val 
1               5                   10                  15      


<210>  571
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  U1-61.1-CDR-1l

<400>  571

Arg Ala Ser Gln Thr Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  572
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-61.1-CDR-2l

<400>  572

Ala Ala Ser Ser Leu Gln Gly 
1               5           


<210>  573
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-61.1-CDR-3l

<400>  573

Gln Gln Ser Tyr Ser Asn Pro Leu Thr 
1               5                   


<210>  574
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-61-CDR-1h

<400>  574

Gly Val Ser Ile Ser Ser Gly Gly Tyr Tyr Trp Ser 
1               5                   10          


<210>  575
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-61-CDR-2h

<400>  575

Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  576
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  U1-61-CDR-3h

<400>  576

Asp Ser Glu Ser Glu Tyr Ser Ser Ser Ser Asn Tyr Gly Met Asp Val 
1               5                   10                  15      


<210>  577
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  U1-62-CDR-1h

<400>  577

Gly Tyr Ser Phe Thr Ser Tyr Trp Ile Gly 
1               5                   10  


<210>  578
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  U1-62-CDR-2h

<400>  578

Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  579
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-62-CDR-3h

<400>  579

Gln Met Ala Gly Asn Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10          


<210>  580
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  U1-62-CDR-1l

<400>  580

Arg Ala Ser Gln Ser Val Ile Ser Ile Tyr Leu Ala 
1               5                   10          


<210>  581
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  U1-62-CDR-2l

<400>  581

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  582
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  U1-62-CDR-3l

<400>  582

Gln Gln Tyr Gly Ser Ser Pro Cys Ser 
1               5                   


