                         SEQUENCE LISTING

<110>  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 
       (I.N.S.E.R.M)
 
<120>  TIM RECEPTORS AS DENGUE VIRUS ENTRY COFACTORS

<130>  BET12P2979

<150>  EP12305193.0    

<151>  2012 02 21    

<150>  EP12306281.2    

<151>  2012 10 17  

<160>  47    

<170>  PatentIn version 3.5

<210>  1
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA against TIM-1 receptor

<400>  1
aaacucaacu guuccuaca                                                    19


<210>  2
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA against TIM-1 receptor

<400>  2
cggaaggaca cacgcuaua                                                    19


<210>  3
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA against TIM-1 receptor

<400>  3
gcagaaaccc acccuacga                                                    19


<210>  4
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA against TIM-1 receptor

<400>  4
ggucacgacu acuccaauu                                                    19


<210>  5
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  5

Met His Pro Gln Val Val Ile Leu Ser Leu Ile Leu His Leu Ala Asp 
1               5                   10                  15      


Ser Val Ala Gly Ser Val Lys Val Gly Gly Glu Ala Gly Pro Ser Val 
            20                  25                  30          


Thr Leu Pro Cys His Tyr Ser Gly Ala Val Thr Ser Met Cys Trp Asn 
        35                  40                  45              


Arg Gly Ser Cys Ser Leu Phe Thr Cys Gln Asn Gly Ile Val Trp Thr 
    50                  55                  60                  


Asn Gly Thr His Val Thr Tyr Arg Lys Asp Thr Arg Tyr Lys Leu Leu 
65                  70                  75                  80  


Gly Asp Leu Ser Arg Arg Asp Val Ser Leu Thr Ile Glu Asn Thr Ala 
                85                  90                  95      


Val Ser Asp Ser Gly Val Tyr Cys Cys Arg Val Glu His Arg Gly Trp 
            100                 105                 110         


Phe Asn Asp Met Lys Ile Thr Val Ser Leu Glu Ile Val Pro Pro Lys 
        115                 120                 125             


Val Thr Thr Thr Pro Ile Val Thr Thr Val Pro Thr Val Thr Thr Val 
    130                 135                 140                 


Arg Thr Ser Thr Thr Val Pro Thr Thr Thr Thr Val Pro Met Thr Thr 
145                 150                 155                 160 


Val Pro Thr Thr Thr Val Pro Thr Thr Met Ser Ile Pro Thr Thr Thr 
                165                 170                 175     


Thr Val Leu Thr Thr Met Thr Val Ser Thr Thr Thr Ser Val Pro Thr 
            180                 185                 190         


Thr Thr Ser Ile Pro Thr Thr Thr Ser Val Pro Val Thr Thr Thr Val 
        195                 200                 205             


Ser Thr Phe Val Pro Pro Met Pro Leu Pro Arg Gln Asn His Glu Pro 
    210                 215                 220                 


Val Ala Thr Ser Pro Ser Ser Pro Gln Pro Ala Glu Thr His Pro Thr 
225                 230                 235                 240 


Thr Leu Gln Gly Ala Ile Arg Arg Glu Pro Thr Ser Ser Pro Leu Tyr 
                245                 250                 255     


Ser Tyr Thr Thr Asp Gly Asn Asp Thr Val Thr Glu Ser Ser Asp Gly 
            260                 265                 270         


Leu Trp Asn Asn Asn Gln Thr Gln Leu Phe Leu Glu His Ser Leu Leu 
        275                 280                 285             


Thr Ala Asn Thr Thr Lys Gly Ile Tyr Ala Gly Val Cys Ile Ser Val 
    290                 295                 300                 


Leu Val Leu Leu Ala Leu Leu Gly Val Ile Ile Ala Lys Lys Tyr Phe 
305                 310                 315                 320 


Phe Lys Lys Glu Val Gln Gln Leu Ser Val Ser Phe Ser Ser Leu Gln 
                325                 330                 335     


Ile Lys Ala Leu Gln Asn Ala Val Glu Lys Glu Val Gln Ala Glu Asp 
            340                 345                 350         


Asn Ile Tyr Ile Glu Asn Ser Leu Tyr Ala Thr Asp 
        355                 360                 


<210>  6
<211>  1841
<212>  DNA
<213>  Homo sapiens

<400>  6
attctcctgc ctcagcctcc cgagtagctg ggactacagg cgccagtgac cacgcccggc       60

taattttttg tatttttagt agagacgggg tttcaccctt ttagccagga tggtctcgat      120

ctcctgactt cgtgatctgc ccgccttggc ctcccaaagt gctaggatta caggtttgag      180

ccaccgcgcc cggccctgtt tcctttttgt ttgttcccct gataccctgt atcaggacca      240

ggagtcagtt tggcggttat gtgtggggaa gaagctggga agtcaggggc tgtttctgtg      300

gacagctttc cctgtccttt ggaaggcaca gagctctcag ctgcagggaa ctaacagagc      360

tctgaagccg ttatatgtgg tcttctctca tttccagcag agcaggctca tatgaatcaa      420

ccaactgggt gaaaagataa gttgcaatct gagatttaag acttgatcag ataccatctg      480

gtggagggta ccaaccagcc tgtctgctca ttttccttca ggctgatccc ataatgcatc      540

ctcaagtggt catcttaagc ctcatcctac atctggcaga ttctgtagct ggttctgtaa      600

aggttggtgg agaggcaggt ccatctgtca cactaccctg ccactacagt ggagctgtca      660

catccatgtg ctggaataga ggctcatgtt ctctattcac atgccaaaat ggcattgtct      720

ggaccaatgg aacccacgtc acctatcgga aggacacacg ctataagcta ttgggggacc      780

tttcaagaag ggatgtctct ttgaccatag aaaatacagc tgtgtctgac agtggcgtat      840

attgttgccg tgttgagcac cgtgggtggt tcaatgacat gaaaatcacc gtatcattgg      900

agattgtgcc acccaaggtc acgactactc caattgtcac aactgttcca accgtcacga      960

ctgttcgaac gagcaccact gttccaacga caacgactgt tccaatgacg actgttccaa     1020

cgacaactgt tccaacaaca atgagcattc caacgacaac gactgttctg acgacaatga     1080

ctgtttcaac gacaacgagc gttccaacga caacgagcat tccaacaaca acaagtgttc     1140

cagtgacaac aactgtctct acctttgttc ctccaatgcc tttgcccagg cagaaccatg     1200

aaccagtagc cacttcacca tcttcacctc agccagcaga aacccaccct acgacactgc     1260

agggagcaat aaggagagaa cccaccagct caccattgta ctcttacaca acagatggga     1320

atgacaccgt gacagagtct tcagatggcc tttggaataa caatcaaact caactgttcc     1380

tagaacatag tctactgacg gccaatacca ctaaaggaat ctatgctgga gtctgtattt     1440

ctgtcttggt gcttcttgct cttttgggtg tcatcattgc caaaaagtat ttcttcaaaa     1500

aggaggttca acaactaagt gtttcattta gcagccttca aattaaagct ttgcaaaatg     1560

cagttgaaaa ggaagtccaa gcagaagaca atatctacat tgagaatagt ctttatgcca     1620

cggactaaga cccagtggtg ctctttgaga gtttacgccc atgagtgcag aagactgaac     1680

agacatcagc acatcagacg tcttttagac cccaagacaa tttttctgtt tcagtttcat     1740

ctggcattcc aacatgtcag tgatactggg tagagtaact ctctcactcc aaactgtgta     1800

tagtcaacct catcattaat gtagtcctaa ttttttatgc t                         1841


<210>  7
<211>  1493
<212>  DNA
<213>  Homo sapiens

<400>  7
attctcctgc ctcagcctcc cgagtagctg ggactacagg cgccagtgac cacgcccggc       60

taattttttg tatttttagt agagacgggg tttcaccctt ttagccagga tggtctcgat      120

ctcctgactt cgtgatctgc ccgccttggc ctcccaaagt gctaggatta caggctgatc      180

ccataatgca tcctcaagtg gtcatcttaa gcctcatcct acatctggca gattctgtag      240

ctggttctgt aaaggttggt ggagaggcag gtccatctgt cacactaccc tgccactaca      300

gtggagctgt cacatccatg tgctggaata gaggctcatg ttctctattc acatgccaaa      360

atggcattgt ctggaccaat ggaacccacg tcacctatcg gaaggacaca cgctataagc      420

tattggggga cctttcaaga agggatgtct ctttgaccat agaaaataca gctgtgtctg      480

acagtggcgt atattgttgc cgtgttgagc accgtgggtg gttcaatgac atgaaaatca      540

ccgtatcatt ggagattgtg ccacccaagg tcacgactac tccaattgtc acaactgttc      600

caaccgtcac gactgttcga acgagcacca ctgttccaac gacaacgact gttccaatga      660

cgactgttcc aacgacaact gttccaacaa caatgagcat tccaacgaca acgactgttc      720

tgacgacaat gactgtttca acgacaacga gcgttccaac gacaacgagc attccaacaa      780

caacaagtgt tccagtgaca acaactgtct ctacctttgt tcctccaatg cctttgccca      840

ggcagaacca tgaaccagta gccacttcac catcttcacc tcagccagca gaaacccacc      900

ctacgacact gcagggagca ataaggagag aacccaccag ctcaccattg tactcttaca      960

caacagatgg gaatgacacc gtgacagagt cttcagatgg cctttggaat aacaatcaaa     1020

ctcaactgtt cctagaacat agtctactga cggccaatac cactaaagga atctatgctg     1080

gagtctgtat ttctgtcttg gtgcttcttg ctcttttggg tgtcatcatt gccaaaaagt     1140

atttcttcaa aaaggaggtt caacaactaa gtgtttcatt tagcagcctt caaattaaag     1200

ctttgcaaaa tgcagttgaa aaggaagtcc aagcagaaga caatatctac attgagaata     1260

gtctttatgc cacggactaa gacccagtgg tgctctttga gagtttacgc ccatgagtgc     1320

agaagactga acagacatca gcacatcaga cgtcttttag accccaagac aatttttctg     1380

tttcagtttc atctggcatt ccaacatgtc agtgatactg ggtagagtaa ctctctcact     1440

ccaaactgtg tatagtcaac ctcatcatta atgtagtcct aattttttat gct            1493


<210>  8
<211>  1359
<212>  DNA
<213>  Homo sapiens

<400>  8
gttacccagc attgtgagtg acagagcctg gatctgaacg ctgatcccat aatgcatcct       60

caagtggtca tcttaagcct catcctacat ctggcagatt ctgtagctgg ttctgtaaag      120

gttggtggag aggcaggtcc atctgtcaca ctaccctgcc actacagtgg agctgtcaca      180

tccatgtgct ggaatagagg ctcatgttct ctattcacat gccaaaatgg cattgtctgg      240

accaatggaa cccacgtcac ctatcggaag gacacacgct ataagctatt gggggacctt      300

tcaagaaggg atgtctcttt gaccatagaa aatacagctg tgtctgacag tggcgtatat      360

tgttgccgtg ttgagcaccg tgggtggttc aatgacatga aaatcaccgt atcattggag      420

attgtgccac ccaaggtcac gactactcca attgtcacaa ctgttccaac cgtcacgact      480

gttcgaacga gcaccactgt tccaacgaca acgactgttc caatgacgac tgttccaacg      540

acaactgttc caacaacaat gagcattcca acgacaacga ctgttctgac gacaatgact      600

gtttcaacga caacgagcgt tccaacgaca acgagcattc caacaacaac aagtgttcca      660

gtgacaacaa ctgtctctac ctttgttcct ccaatgcctt tgcccaggca gaaccatgaa      720

ccagtagcca cttcaccatc ttcacctcag ccagcagaaa cccaccctac gacactgcag      780

ggagcaataa ggagagaacc caccagctca ccattgtact cttacacaac agatgggaat      840

gacaccgtga cagagtcttc agatggcctt tggaataaca atcaaactca actgttccta      900

gaacatagtc tactgacggc caataccact aaaggaatct atgctggagt ctgtatttct      960

gtcttggtgc ttcttgctct tttgggtgtc atcattgcca aaaagtattt cttcaaaaag     1020

gaggttcaac aactaagtgt ttcatttagc agccttcaaa ttaaagcttt gcaaaatgca     1080

gttgaaaagg aagtccaagc agaagacaat atctacattg agaatagtct ttatgccacg     1140

gactaagacc cagtggtgct ctttgagagt ttacgcccat gagtgcagaa gactgaacag     1200

acatcagcac atcagacgtc ttttagaccc caagacaatt tttctgtttc agtttcatct     1260

ggcattccaa catgtcagtg atactgggta gagtaactct ctcactccaa actgtgtata     1320

gtcaacctca tcattaatgt agtcctaatt ttttatgct                            1359


<210>  9
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Phe Ser His Leu Pro Phe Asp Cys Val Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Thr Arg Ser Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln 
            20                  25                  30          


Asn Ala Tyr Leu Pro Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu 
        35                  40                  45              


Val Pro Val Cys Trp Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly 
    50                  55                  60                  


Asn Val Val Leu Arg Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser 
65                  70                  75                  80  


Arg Tyr Trp Leu Asn Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr 
                85                  90                  95      


Ile Glu Asn Val Thr Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile 
            100                 105                 110         


Gln Ile Pro Gly Ile Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val 
        115                 120                 125             


Ile Lys Pro Gly Glu Trp Thr Phe Ala Cys His Leu Tyr Glu 
    130                 135                 140         


<210>  10
<211>  301
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Phe Ser His Leu Pro Phe Asp Cys Val Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Thr Arg Ser Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln 
            20                  25                  30          


Asn Ala Tyr Leu Pro Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu 
        35                  40                  45              


Val Pro Val Cys Trp Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly 
    50                  55                  60                  


Asn Val Val Leu Arg Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser 
65                  70                  75                  80  


Arg Tyr Trp Leu Asn Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr 
                85                  90                  95      


Ile Glu Asn Val Thr Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile 
            100                 105                 110         


Gln Ile Pro Gly Ile Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val 
        115                 120                 125             


Ile Lys Pro Ala Lys Val Thr Pro Ala Pro Thr Leu Gln Arg Asp Phe 
    130                 135                 140                 


Thr Ala Ala Phe Pro Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala 
145                 150                 155                 160 


Glu Thr Gln Thr Leu Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile 
                165                 170                 175     


Ser Thr Leu Ala Asn Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu 
            180                 185                 190         


Arg Asp Ser Gly Ala Thr Ile Arg Ile Gly Ile Tyr Ile Gly Ala Gly 
        195                 200                 205             


Ile Cys Ala Gly Leu Ala Leu Ala Leu Ile Phe Gly Ala Leu Ile Phe 
    210                 215                 220                 


Lys Trp Tyr Ser His Ser Lys Glu Lys Ile Gln Asn Leu Ser Leu Ile 
225                 230                 235                 240 


Ser Leu Ala Asn Leu Pro Pro Ser Gly Leu Ala Asn Ala Val Ala Glu 
                245                 250                 255     


Gly Ile Arg Ser Glu Glu Asn Ile Tyr Thr Ile Glu Glu Asn Val Tyr 
            260                 265                 270         


Glu Val Glu Glu Pro Asn Glu Tyr Tyr Cys Tyr Val Ser Ser Arg Gln 
        275                 280                 285             


Gln Pro Ser Gln Pro Leu Gly Cys Arg Phe Ala Met Pro 
    290                 295                 300     


<210>  11
<211>  2448
<212>  DNA
<213>  Homo sapiens

<400>  11
agaacactta caggatgtgt gtagtgtggc atgacagaga actttggttt cctttaatgt       60

gactgtagac ctggcagtgt tactataaga atcactggca atcagacacc cgggtgtgct      120

gagctagcac tcagtggggg cggctactgc tcatgtgatt gtggagtaga cagttggaag      180

aagtacccag tccatttgga gagttaaaac tgtgcctaac agaggtgtcc tctgactttt      240

cttctgcaag ctccatgttt tcacatcttc cctttgactg tgtcctgctg ctgctgctgc      300

tactacttac aaggtcctca gaagtggaat acagagcgga ggtcggtcag aatgcctatc      360

tgccctgctt ctacacccca gccgccccag ggaacctcgt gcccgtctgc tggggcaaag      420

gagcctgtcc tgtgtttgaa tgtggcaacg tggtgctcag gactgatgaa agggatgtga      480

attattggac atccagatac tggctaaatg gggatttccg caaaggagat gtgtccctga      540

ccatagagaa tgtgactcta gcagacagtg ggatctactg ctgccggatc caaatcccag      600

gcataatgaa tgatgaaaaa tttaacctga agttggtcat caaaccagcc aaggtcaccc      660

ctgcaccgac tcggcagaga gacttcactg cagcctttcc aaggatgctt accaccaggg      720

gacatggccc agcagagaca cagacactgg ggagcctccc tgatataaat ctaacacaaa      780

tatccacatt ggccaatgag ttacgggact ctagattggc caatgactta cgggactctg      840

gagcaaccat cagaataggc atctacatcg gagcagggat ctgtgctggg ctggctctgg      900

ctcttatctt cggcgcttta attttcaaat ggtattctca tagcaaagag aagatacaga      960

atttaagcct catctctttg gccaacctcc ctccctcagg attggcaaat gcagtagcag     1020

agggaattcg ctcagaagaa aacatctata ccattgaaga gaacgtatat gaagtggagg     1080

agcccaatga gtattattgc tatgtcagca gcaggcagca accctcacaa cctttgggtt     1140

gtcgctttgc aatgccatag atccaaccac cttatttttg agcttggtgt tttgtctttt     1200

tcagaaacta tgagctgtgt cacctgactg gttttggagg ttctgtccac tgctatggag     1260

cagagttttc ccattttcag aagataatga ctcacatggg aattgaactg ggacctgcac     1320

tgaacttaaa caggcatgtc attgcctctg tatttaagcc aacagagtta cccaacccag     1380

agactgttaa tcatggatgt tagagctcaa acgggctttt atatacacta ggaattcttg     1440

acgtggggtc tctggagctc caggaaattc gggcacatca tatgtccatg aaacttcaga     1500

taaactaggg aaaactgggt gctgaggtga aagcataact tttttggcac agaaagtcta     1560

aaggggccac tgattttcaa agagatctgt gatccctttt tgttttttgt ttttgagatg     1620

gagtcttgct ctgttgccca ggctggagtg caatggcaca atctcggctc actgcaagct     1680

ccgcctcctg ggttcaagcg attctcctgc ctcagcctcc tgagtggctg ggattacagg     1740

catgcaccac catgcccagc taatttgttg tatttttagt agagacaggg tttcaccatg     1800

ttggccagtg tggtctcaaa ctcctgacct catgatttgc ctgcctcggc ctcccaaagc     1860

actgggatta caggcgtgag ccaccacatc cagccagtga tccttaaaag attaagagat     1920

gactggacca ggtctacctt gatcttgaag attcccttgg aatgttgaga tttaggctta     1980

tttgagcact gcctgcccaa ctgtcagtgc cagtgcatag cccttctttt gtctccctta     2040

tgaagactgc cctgcagggc tgagatgtgg caggagctcc cagggaaaaa cgaagtgcat     2100

ttgattggtg tgtattggcc aagttttgct tgttgtgtgc ttgaaagaaa atatctctga     2160

ccaacttctg tattcgtgga ccaaactgaa gctatatttt tcacagaaga agaagcagtg     2220

acggggacac aaattctgtt gcctggtgga aagaaggcaa aggccttcag caatctatat     2280

taccagcgct ggatcctttg acagagagtg gtccctaaac ttaaatttca agacggtata     2340

ggcttgatct gtcttgctta ttgttgcccc ctgcgcctag cacaattctg acacacaatt     2400

ggaacttact aaaaattttt ttttactgtt aaaaaaaaaa aaaaaaaa                  2448


<210>  12
<211>  378
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Glu Ser Lys 
                245                 250                 255     


Val Trp Asp Leu Pro Ser Thr Ser His Val Ser Met Trp Lys Thr Ser 
            260                 265                 270         


Asp Ser Val Ser Ser Pro Gln Pro Gly Ala Ser Asp Thr Ala Val Pro 
        275                 280                 285             


Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp Gly Ile Pro Met 
    290                 295                 300                 


Ser Met Lys Asn Glu Met Pro Ile Ser Gln Leu Leu Met Ile Ile Ala 
305                 310                 315                 320 


Pro Ser Leu Gly Phe Val Leu Phe Ala Leu Phe Val Ala Phe Leu Leu 
                325                 330                 335     


Arg Gly Lys Leu Met Glu Thr Tyr Cys Ser Gln Lys His Thr Arg Leu 
            340                 345                 350         


Asp Tyr Ile Gly Asp Ser Lys Asn Val Leu Asn Asp Val Gln His Gly 
        355                 360                 365             


Arg Glu Asp Glu Asp Gly Leu Phe Thr Leu 
    370                 375             


<210>  13
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ser Lys Glu Pro Leu Ile Leu Trp Leu Met Ile Glu Phe Trp Trp 
1               5                   10                  15      


Leu Tyr Leu Thr Pro Val Thr Ser Glu Thr Val Val Thr Glu Val Leu 
            20                  25                  30          


Gly His Arg Val Thr Leu Pro Cys Leu Tyr Ser Ser Trp Ser His Asn 
        35                  40                  45              


Ser Asn Ser Met Cys Trp Gly Lys Asp Gln Cys Pro Tyr Ser Gly Cys 
    50                  55                  60                  


Lys Glu Ala Leu Ile Arg Thr Asp Gly Met Arg Val Thr Ser Arg Lys 
65                  70                  75                  80  


Ser Ala Lys Tyr Arg Leu Gln Gly Thr Ile Pro Arg Gly Asp Val Ser 
                85                  90                  95      


Leu Thr Ile Leu Asn Pro Ser Glu Ser Asp Ser Gly Val Tyr Cys Cys 
            100                 105                 110         


Arg Ile Glu Val Pro Gly Trp Phe Asn Asp Val Lys Ile Asn Val Arg 
        115                 120                 125             


Leu Asn Leu Gln Arg Ala Ser Thr Thr Thr His Arg Thr Ala Thr Thr 
    130                 135                 140                 


Thr Thr Arg Arg Thr Thr Thr Thr Ser Pro Thr Thr Thr Arg Gln Met 
145                 150                 155                 160 


Thr Thr Thr Pro Ala Ala Leu Pro Thr Thr Val Val Thr Thr Pro Asp 
                165                 170                 175     


Leu Thr Thr Gly Thr Pro Leu Gln Met Thr Thr Ile Ala Val Phe Thr 
            180                 185                 190         


Thr Ala Asn Thr Cys Leu Ser Leu Thr Pro Ser Thr Leu Pro Glu Glu 
        195                 200                 205             


Ala Thr Gly Leu Leu Thr Pro Glu Pro Ser Lys Glu Gly Pro Ile Leu 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Val Leu Pro Ser Asp Ser Trp Ser Ser Val 
225                 230                 235                 240 


Glu Ser Thr Ser Ala Asp Thr Val Leu Leu Thr Ser Lys Ala Ser Asp 
                245                 250                 255     


Thr Ala Val Pro Glu Gln Asn Lys Thr Thr Lys Thr Gly Gln Met Asp 
            260                 265                 270         


Gly Ile Pro Met Ser Met Lys Asn Glu Met Pro Ile Ser Gln Leu Leu 
        275                 280                 285             


Met Ile Ile Ala Pro Ser Leu Gly Phe Val Leu Phe Ala Leu Phe Val 
    290                 295                 300                 


Ala Phe Leu Leu Arg Gly Lys Leu Met Glu Thr Tyr Cys Ser Gln Lys 
305                 310                 315                 320 


His Thr Arg Leu Asp Tyr Ile Gly Asp Ser Lys Asn Val Leu Asn Asp 
                325                 330                 335     


Val Gln His Gly Arg Glu Asp Glu Asp Gly Leu Phe Thr Leu 
            340                 345                 350 


<210>  14
<211>  1374
<212>  DNA
<213>  Homo sapiens

<400>  14
ataagaggtt gggctttgga tagatagaca gactcctggg tccggtcaac cgtcaaaatg       60

tccaaagaac ctctcattct ctggctgatg attgagtttt ggtggcttta cctgacacca      120

gtcacttcag agactgttgt gacggaggtt ttgggtcacc gggtgacttt gccctgtctg      180

tactcatcct ggtctcacaa cagcaacagc atgtgctggg ggaaagacca gtgcccctac      240

tccggttgca aggaggcgct catccgcact gatggaatga gggtgacctc aagaaagtca      300

gcaaaatata gacttcaggg gactatcccg agaggtgatg tctccttgac catcttaaac      360

cccagtgaaa gtgacagcgg tgtgtactgc tgccgcatag aagtgcctgg ctggttcaac      420

gatgtaaaga taaacgtgcg cctgaatcta cagagagcct caacaaccac gcacagaaca      480

gcaaccacca ccacacgcag aacaacaaca acaagcccca ccaccacccg acaaatgaca      540

acaaccccag ctgcacttcc aacaacagtc gtgaccacac ccgatctcac aaccggaaca      600

ccactccaga tgacaaccat tgccgtcttc acaacagcaa acacgtgcct ttcactaacc      660

ccaagcaccc ttccggagga agccacaggt cttctgactc ccgagccttc taaggaaggg      720

cccatcctca ctgcagaatc agaaactgtc ctccccagtg attcctggag tagtgttgag      780

tctacttctg ctgacactgt cctgctgaca tccaaagagt ccaaagtttg ggatctccca      840

tcaacatccc acgtgtcaat gtggaaaacg agtgattctg tgtcttctcc tcagcctgga      900

gcatctgata cagcagttcc tgagcagaac aaaacaacaa aaacaggaca gatggatgga      960

atacccatgt caatgaagaa tgaaatgccc atctcccaac tactgatgat catcgccccc     1020

tccttgggat ttgtgctctt cgcattgttt gtggcgtttc tcctgagagg gaaactcatg     1080

gaaacctatt gttcgcagaa acacacaagg ctagactaca ttggagatag taaaaatgtc     1140

ctcaatgacg tgcagcatgg aagggaagac gaagacggcc tttttaccct ctaacaacgc     1200

agtagcatgt tagattgagg atgggggcat gacactccag tgtcaaaata agtcttagta     1260

gatttccttg tttcataaaa aagactcact tattccatgg atgtcattga tccaggcttg     1320

ctttagtttc atgaatgaag ggtactttag agaccacaac ttctctgtca aaaa           1374


<210>  15
<211>  1290
<212>  DNA
<213>  Homo sapiens

<400>  15
ataagaggtt gggctttgga tagatagaca gactcctggg tccggtcaac cgtcaaaatg       60

tccaaagaac ctctcattct ctggctgatg attgagtttt ggtggcttta cctgacacca      120

gtcacttcag agactgttgt gacggaggtt ttgggtcacc gggtgacttt gccctgtctg      180

tactcatcct ggtctcacaa cagcaacagc atgtgctggg ggaaagacca gtgcccctac      240

tccggttgca aggaggcgct catccgcact gatggaatga gggtgacctc aagaaagtca      300

gcaaaatata gacttcaggg gactatcccg agaggtgatg tctccttgac catcttaaac      360

cccagtgaaa gtgacagcgg tgtgtactgc tgccgcatag aagtgcctgg ctggttcaac      420

gatgtaaaga taaacgtgcg cctgaatcta cagagagcct caacaaccac gcacagaaca      480

gcaaccacca ccacacgcag aacaacaaca acaagcccca ccaccacccg acaaatgaca      540

acaaccccag ctgcacttcc aacaacagtc gtgaccacac ccgatctcac aaccggaaca      600

ccactccaga tgacaaccat tgccgtcttc acaacagcaa acacgtgcct ttcactaacc      660

ccaagcaccc ttccggagga agccacaggt cttctgactc ccgagccttc taaggaaggg      720

cccatcctca ctgcagaatc agaaactgtc ctccccagtg attcctggag tagtgttgag      780

tctacttctg ctgacactgt cctgctgaca tccaaagcat ctgatacagc agttcctgag      840

cagaacaaaa caacaaaaac aggacagatg gatggaatac ccatgtcaat gaagaatgaa      900

atgcccatct cccaactact gatgatcatc gccccctcct tgggatttgt gctcttcgca      960

ttgtttgtgg cgtttctcct gagagggaaa ctcatggaaa cctattgttc gcagaaacac     1020

acaaggctag actacattgg agatagtaaa aatgtcctca atgacgtgca gcatggaagg     1080

gaagacgaag acggcctttt taccctctaa caacgcagta gcatgttaga ttgaggatgg     1140

gggcatgaca ctccagtgtc aaaataagtc ttagtagatt tccttgtttc ataaaaaaga     1200

ctcacttatt ccatggatgt cattgatcca ggcttgcttt agtttcatga atgaagggta     1260

ctttagagac cacaacttct ctgtcaaaaa                                      1290


<210>  16
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Gln Val Leu Arg Gly Thr Val Thr Asp Phe Pro Gly Phe Asp 
1               5                   10                  15      


Glu Arg Ala Asp Ala Glu Thr Leu Arg Lys Ala Met Lys Gly Leu Gly 
            20                  25                  30          


Thr Asp Glu Glu Ser Ile Leu Thr Leu Leu Thr Ser Arg Ser Asn Ala 
        35                  40                  45              


Gln Arg Gln Glu Ile Ser Ala Ala Phe Lys Thr Leu Phe Gly Arg Asp 
    50                  55                  60                  


Leu Leu Asp Asp Leu Lys Ser Glu Leu Thr Gly Lys Phe Glu Lys Leu 
65                  70                  75                  80  


Ile Val Ala Leu Met Lys Pro Ser Arg Leu Tyr Asp Ala Tyr Glu Leu 
                85                  90                  95      


Lys His Ala Leu Lys Gly Ala Gly Thr Asn Glu Lys Val Leu Thr Glu 
            100                 105                 110         


Ile Ile Ala Ser Arg Thr Pro Glu Glu Leu Arg Ala Ile Lys Gln Val 
        115                 120                 125             


Tyr Glu Glu Glu Tyr Gly Ser Ser Leu Glu Asp Asp Val Val Gly Asp 
    130                 135                 140                 


Thr Ser Gly Tyr Tyr Gln Arg Met Leu Val Val Leu Leu Gln Ala Asn 
145                 150                 155                 160 


Arg Asp Pro Asp Ala Gly Ile Asp Glu Ala Gln Val Glu Gln Asp Ala 
                165                 170                 175     


Gln Ala Leu Phe Gln Ala Gly Glu Leu Lys Trp Gly Thr Asp Glu Glu 
            180                 185                 190         


Lys Phe Ile Thr Ile Phe Gly Thr Arg Ser Val Ser His Leu Arg Lys 
        195                 200                 205             


Val Phe Asp Lys Tyr Met Thr Ile Ser Gly Phe Gln Ile Glu Glu Thr 
    210                 215                 220                 


Ile Asp Arg Glu Thr Ser Gly Asn Leu Glu Gln Leu Leu Leu Ala Val 
225                 230                 235                 240 


Val Lys Ser Ile Arg Ser Ile Pro Ala Tyr Leu Ala Glu Thr Leu Tyr 
                245                 250                 255     


Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp His Thr Leu Ile Arg Val 
            260                 265                 270         


Met Val Ser Arg Ser Glu Ile Asp Leu Phe Asn Ile Arg Lys Glu Phe 
        275                 280                 285             


Arg Lys Asn Phe Ala Thr Ser Leu Tyr Ser Met Ile Lys Gly Asp Thr 
    290                 295                 300                 


Ser Gly Asp Tyr Lys Lys Ala Leu Leu Leu Leu Cys Gly Glu Asp Asp 
305                 310                 315                 320 


<210>  17
<211>  4743
<212>  DNA
<213>  Homo sapiens

<400>  17
gggaaggagg caggggtgct gagaaggcgg ctgctgggca gagccggtgg caagggcctc       60

ccctgccgct gtgccaggca ggcagtgcca aatccgggga gcctggagct ggggggaggg      120

ccggggacag cccggccctg ccccctcccc cgctgggagc ccaacaactt ctgaggaaag      180

tttggcaccc atggcgtggc ggtgccccag gatgggcagg gtcccgctgg cctggtgctt      240

ggcgctgtgc ggctgggcgt gcatggcccc caggggcacg caggctgaag aaagtccctt      300

cgtgggcaac ccagggaata tcacaggtgc ccggggactc acgggcaccc ttcggtgtca      360

gctccaggtt cagggagagc cccccgaggt acattggctt cgggatggac agatcctgga      420

gctcgcggac agcacccaga cccaggtgcc cctgggtgag gatgaacagg atgactggat      480

agtggtcagc cagctcagaa tcacctccct gcagctttcc gacacgggac agtaccagtg      540

tttggtgttt ctgggacatc agaccttcgt gtcccagcct ggctatgttg ggctggaggg      600

cttgccttac ttcctggagg agcccgaaga caggactgtg gccgccaaca cccccttcaa      660

cctgagctgc caagctcagg gacccccaga gcccgtggac ctactctggc tccaggatgc      720

tgtccccctg gccacggctc caggtcacgg cccccagcgc agcctgcatg ttccagggct      780

gaacaagaca tcctctttct cctgcgaagc ccataacgcc aagggggtca ccacatcccg      840

cacagccacc atcacagtgc tcccccagca gccccgtaac ctccacctgg tctcccgcca      900

acccacggag ctggaggtgg cttggactcc aggcctgagc ggcatctacc ccctgaccca      960

ctgcaccctg caggctgtgc tgtcagacga tgggatgggc atccaggcgg gagaaccaga     1020

ccccccagag gagcccctca cctcgcaagc atccgtgccc ccccatcagc ttcggctagg     1080

cagcctccat cctcacaccc cttatcacat ccgcgtggca tgcaccagca gccagggccc     1140

ctcatcctgg acccactggc ttcctgtgga gacgccggag ggagtgcccc tgggcccccc     1200

tgagaacatt agtgctacgc ggaatgggag ccaggccttc gtgcattggc aagagccccg     1260

ggcgcccctg cagggtaccc tgttagggta ccggctggcg tatcaaggcc aggacacccc     1320

agaggtgcta atggacatag ggctaaggca agaggtgacc ctggagctgc agggggacgg     1380

gtctgtgtcc aatctgacag tgtgtgtggc agcctacact gctgctgggg atggaccctg     1440

gagcctccca gtacccctgg aggcctggcg cccagggcaa gcacagccag tccaccagct     1500

ggtgaaggaa ccttcaactc ctgccttctc gtggccctgg tggtatgtac tgctaggagc     1560

agtcgtggcc gctgcctgtg tcctcatctt ggctctcttc cttgtccacc ggcgaaagaa     1620

ggagacccgt tatggagaag tgtttgaacc aacagtggaa agaggtgaac tggtagtcag     1680

gtaccgcgtg cgcaagtcct acagtcgtcg gaccactgaa gctaccttga acagcctggg     1740

catcagtgaa gagctgaagg agaagctgcg ggatgtgatg gtggaccggc acaaggtggc     1800

cctggggaag actctgggag agggagagtt tggagctgtg atggaaggcc agctcaacca     1860

ggacgactcc atcctcaagg tggctgtgaa gacgatgaag attgccatct gcacgaggtc     1920

agagctggag gatttcctga gtgaagcggt ctgcatgaag gaatttgacc atcccaacgt     1980

catgaggctc atcggtgtct gtttccaggg ttctgaacga gagagcttcc cagcacctgt     2040

ggtcatctta cctttcatga aacatggaga cctacacagc ttcctcctct attcccggct     2100

cggggaccag ccagtgtacc tgcccactca gatgctagtg aagttcatgg cagacatcgc     2160

cagtggcatg gagtatctga gtaccaagag attcatacac cgggacctgg cggccaggaa     2220

ctgcatgctg aatgagaaca tgtccgtgtg tgtggcggac ttcgggctct ccaagaagat     2280

ctacaatggg gactactacc gccagggacg tatcgccaag atgccagtca agtggattgc     2340

cattgagagt ctagctgacc gtgtctacac cagcaagagc gatgtgtggt ccttcggggt     2400

gacaatgtgg gagattgcca caagaggcca aaccccatat ccgggcgtgg agaacagcga     2460

gatttatgac tatctgcgcc agggaaatcg cctgaagcag cctgcggact gtctggatgg     2520

actgtatgcc ttgatgtcgc ggtgctggga gctaaatccc caggaccggc caagttttac     2580

agagctgcgg gaagatttgg agaacacact gaaggccttg cctcctgccc aggagcctga     2640

cgaaatcctc tatgtcaaca tggatgaggg tggaggttat cctgaacccc ctggagctgc     2700

aggaggagct gaccccccaa cccagccaga ccctaaggat tcctgtagct gcctcactgc     2760

ggctgaggtc catcctgctg gacgctatgt cctctgccct tccacaaccc ctagccccgc     2820

tcagcctgct gataggggct ccccagcagc cccagggcag gaggatggtg cctgagacaa     2880

ccctccacct ggtactccct ctcaggatcc aagctaagca ctgccactgg ggaaaactcc     2940

accttcccac tttcccaccc cacgccttat ccccacttgc agccctgtct tcctacctat     3000

cccacctcca tcccagacag gtccctcccc ttctctgtgc agtagcatca ccttgaaagc     3060

agtagcatca ccatctgtaa aaggaagggg ttggattgca atatctgaag ccctcccagg     3120

tgttaacatt ccaagactct agagtccaag gtttaaagag tctagattca aaggttctag     3180

gtttcaaaga tgctgtgagt ctttggttct aaggacctga aattccaaag tctctaattc     3240

tattaaagtg ctaaggttct aaggcctact tttttttttt tttttttttt tttttttttt     3300

gcgatagagt ctcactgtgt cacccaggct ggagtgcagt ggtgcaatct cgcctcactg     3360

caaccttcac ctaccgagtt caagtgattt tcctgccttg gcctcccaag tagctgggat     3420

tacaggtgtg tgccaccaca cccggctaat ttttatattt ttagtagaga cagggtttca     3480

ccatgttggc caggctggtc taaaactcct gacctcaagt gatctgccca cctcagcctc     3540

ccaaagtgct gagattacag gcatgagcca ctgcactcaa ccttaagacc tactgttcta     3600

aagctctgac attatgtggt tttagatttt ctggttctaa catttttgat aaagcctcaa     3660

ggttttaggt tctaaagttc taagattctg attttaggag ctaaggctct atgagtctag     3720

atgtttattc ttctagagtt cagagtcctt aaaatgtaag attatagatt ctaaagattc     3780

tatagttcta gacatggagg ttctaaggcc taggattcta aaatgtgatg ttctaaggct     3840

ctgagagtct agattctctg gctgtaaggc tctagatcat aaggcttcaa aatgttatct     3900

tctcaagttc taagattcta atgatgatca attatagttt ctgaggcttt atgataatag     3960

attctcttgt ataagatcct agatcctaag ggtcgaaagc tctagaatct gcaattcaaa     4020

agttccaaga gtctaaagat ggagtttcta aggtccggtg ttctaagatg tgatattcta     4080

agacttactc taagatctta gattctctgt gtctaagatt ctagatcaga tgctccaaga     4140

ttctagatga ttaaataaga ttctaacggt ctgttctgtt tcaaggcact ctagattcca     4200

ttggtccaag attccggatc ctaagcatct aagttataag actctcacac tcagttgtga     4260

ctaactagac accaaagttc taataatttc taatgttgga cacctttagg ttctttgctg     4320

cattctgcct ctctaggacc atggttaaga gtccaagaat ccacatttct aaaatcttat     4380

agttctaggc actgtagttc taagactcaa atgttctaag tttctaagat tctaaaggtc     4440

cacaggtcta gactattagg tgcaatttca aggttctaac cctatactgt agtattcttt     4500

ggggtgcccc tctccttctt agctatcatt gcttcctcct ccccaactgt gggggtgtgc     4560

ccccttcaag cctgtgcaat gcattaggga tgcctccttt cccgcagggg atggacgatc     4620

tcccaccttt cgggccatgt tgcccccgtg agccaatccc tcaccttctg agtacagagt     4680

gtggactctg gtgcctccag aggggctcag gtcacataaa actttgtata tcaacgaaaa     4740

aaa                                                                   4743


<210>  18
<211>  890
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ala Leu Arg Arg Ser Met Gly Arg Pro Gly Leu Pro Pro Leu Pro 
1               5                   10                  15      


Leu Pro Pro Pro Pro Arg Leu Gly Leu Leu Leu Ala Ala Leu Ala Ser 
            20                  25                  30          


Leu Leu Leu Pro Glu Ser Ala Ala Ala Gly Leu Lys Leu Met Gly Ala 
        35                  40                  45              


Pro Val Lys Leu Thr Val Ser Gln Gly Gln Pro Val Lys Leu Asn Cys 
    50                  55                  60                  


Ser Val Glu Gly Met Glu Glu Pro Asp Ile Gln Trp Val Lys Asp Gly 
65                  70                  75                  80  


Ala Val Val Gln Asn Leu Asp Gln Leu Tyr Ile Pro Val Ser Glu Gln 
                85                  90                  95      


His Trp Ile Gly Phe Leu Ser Leu Lys Ser Val Glu Arg Ser Asp Ala 
            100                 105                 110         


Gly Arg Tyr Trp Cys Gln Val Glu Asp Gly Gly Glu Thr Glu Ile Ser 
        115                 120                 125             


Gln Pro Val Trp Leu Thr Val Glu Gly Val Pro Phe Phe Thr Val Glu 
    130                 135                 140                 


Pro Lys Asp Leu Ala Val Pro Pro Asn Ala Pro Phe Gln Leu Ser Cys 
145                 150                 155                 160 


Glu Ala Val Gly Pro Pro Glu Pro Val Thr Ile Val Trp Trp Arg Gly 
                165                 170                 175     


Thr Thr Lys Ile Gly Gly Pro Ala Pro Ser Pro Ser Val Leu Asn Val 
            180                 185                 190         


Thr Gly Val Thr Gln Ser Thr Met Phe Ser Cys Glu Ala His Asn Leu 
        195                 200                 205             


Lys Gly Leu Ala Ser Ser Arg Thr Ala Thr Val His Leu Gln Ala Leu 
    210                 215                 220                 


Pro Ala Ala Pro Phe Asn Ile Thr Val Thr Lys Leu Ser Ser Ser Asn 
225                 230                 235                 240 


Ala Ser Val Ala Trp Met Pro Gly Ala Asp Gly Arg Ala Leu Leu Gln 
                245                 250                 255     


Ser Cys Thr Val Gln Val Thr Gln Ala Pro Gly Gly Trp Glu Val Leu 
            260                 265                 270         


Ala Val Val Val Pro Val Pro Pro Phe Thr Cys Leu Leu Arg Asp Leu 
        275                 280                 285             


Val Pro Ala Thr Asn Tyr Ser Leu Arg Val Arg Cys Ala Asn Ala Leu 
    290                 295                 300                 


Gly Pro Ser Pro Tyr Ala Asp Trp Val Pro Phe Gln Thr Lys Gly Leu 
305                 310                 315                 320 


Ala Pro Ala Ser Ala Pro Gln Asn Leu His Ala Ile Arg Thr Asp Ser 
                325                 330                 335     


Gly Leu Ile Leu Glu Trp Glu Glu Val Ile Pro Glu Ala Pro Leu Glu 
            340                 345                 350         


Gly Pro Leu Gly Pro Tyr Lys Leu Ser Trp Val Gln Asp Asn Gly Thr 
        355                 360                 365             


Gln Asp Glu Leu Thr Val Glu Gly Thr Arg Ala Asn Leu Thr Gly Trp 
    370                 375                 380                 


Asp Pro Gln Lys Asp Leu Ile Val Arg Val Cys Val Ser Asn Ala Val 
385                 390                 395                 400 


Gly Cys Gly Pro Trp Ser Gln Pro Leu Val Val Ser Ser His Asp Arg 
                405                 410                 415     


Ala Gly Gln Gln Gly Pro Pro His Ser Arg Thr Ser Trp Val Pro Val 
            420                 425                 430         


Val Leu Gly Val Leu Thr Ala Leu Val Thr Ala Ala Ala Leu Ala Leu 
        435                 440                 445             


Ile Leu Leu Arg Lys Arg Arg Lys Glu Thr Arg Phe Gly Gln Ala Phe 
    450                 455                 460                 


Asp Ser Val Met Ala Arg Gly Glu Pro Ala Val His Phe Arg Ala Ala 
465                 470                 475                 480 


Arg Ser Phe Asn Arg Glu Arg Pro Glu Arg Ile Glu Ala Thr Leu Asp 
                485                 490                 495     


Ser Leu Gly Ile Ser Asp Glu Leu Lys Glu Lys Leu Glu Asp Val Leu 
            500                 505                 510         


Ile Pro Glu Gln Gln Phe Thr Leu Gly Arg Met Leu Gly Lys Gly Glu 
        515                 520                 525             


Phe Gly Ser Val Arg Glu Ala Gln Leu Lys Gln Glu Asp Gly Ser Phe 
    530                 535                 540                 


Val Lys Val Ala Val Lys Met Leu Lys Ala Asp Ile Ile Ala Ser Ser 
545                 550                 555                 560 


Asp Ile Glu Glu Phe Leu Arg Glu Ala Ala Cys Met Lys Glu Phe Asp 
                565                 570                 575     


His Pro His Val Ala Lys Leu Val Gly Val Ser Leu Arg Ser Arg Ala 
            580                 585                 590         


Lys Gly Arg Leu Pro Ile Pro Met Val Ile Leu Pro Phe Met Lys His 
        595                 600                 605             


Gly Asp Leu His Ala Phe Leu Leu Ala Ser Arg Ile Gly Glu Asn Pro 
    610                 615                 620                 


Phe Asn Leu Pro Leu Gln Thr Leu Ile Arg Phe Met Val Asp Ile Ala 
625                 630                 635                 640 


Cys Gly Met Glu Tyr Leu Ser Ser Arg Asn Phe Ile His Arg Asp Leu 
                645                 650                 655     


Ala Ala Arg Asn Cys Met Leu Ala Glu Asp Met Thr Val Cys Val Ala 
            660                 665                 670         


Asp Phe Gly Leu Ser Arg Lys Ile Tyr Ser Gly Asp Tyr Tyr Arg Gln 
        675                 680                 685             


Gly Cys Ala Ser Lys Leu Pro Val Lys Trp Leu Ala Leu Glu Ser Leu 
    690                 695                 700                 


Ala Asp Asn Leu Tyr Thr Val Gln Ser Asp Val Trp Ala Phe Gly Val 
705                 710                 715                 720 


Thr Met Trp Glu Ile Met Thr Arg Gly Gln Thr Pro Tyr Ala Gly Ile 
                725                 730                 735     


Glu Asn Ala Glu Ile Tyr Asn Tyr Leu Ile Gly Gly Asn Arg Leu Lys 
            740                 745                 750         


Gln Pro Pro Glu Cys Met Glu Asp Val Tyr Asp Leu Met Tyr Gln Cys 
        755                 760                 765             


Trp Ser Ala Asp Pro Lys Gln Arg Pro Ser Phe Thr Cys Leu Arg Met 
    770                 775                 780                 


Glu Leu Glu Asn Ile Leu Gly Gln Leu Ser Val Leu Ser Ala Ser Gln 
785                 790                 795                 800 


Asp Pro Leu Tyr Ile Asn Ile Glu Arg Ala Glu Glu Pro Thr Ala Gly 
                805                 810                 815     


Gly Ser Leu Glu Leu Pro Gly Arg Asp Gln Pro Tyr Ser Gly Ala Gly 
            820                 825                 830         


Asp Gly Ser Gly Met Gly Ala Val Gly Gly Thr Pro Ser Asp Cys Arg 
        835                 840                 845             


Tyr Ile Leu Thr Pro Gly Gly Leu Ala Glu Gln Pro Gly Gln Ala Glu 
    850                 855                 860                 


His Gln Pro Glu Ser Pro Leu Asn Glu Thr Gln Arg Leu Leu Leu Leu 
865                 870                 875                 880 


Gln Gln Gly Leu Leu Pro His Ser Ser Cys 
                885                 890 


<210>  19
<211>  4001
<212>  DNA
<213>  Homo sapiens

<400>  19
agtggaagga gcgcggtggc gcgggagcgg ccccggggac cccgcgctgc tgacggcggc       60

gaccgcggcc ggaggcgggc gcgggtctcg gaggcggtcg cctcagcacc gccccacggg      120

cggccccagc ccctcccgca gccctcctcc ctcccgctcc cttcccgccg cctcctcccc      180

gccctcctcc ctcctcgctc gcgggccggg cccggcatgg tgcggcgtcg ccgccgatgg      240

cgctgaggcg gagcatgggg cggccggggc tcccgccgct gccgctgccg ccgccaccgc      300

ggctcgggct gctgctggcg gctctggctt ctctgctgct cccggagtcc gccgccgcag      360

gtctgaagct catgggagcc ccggtgaagc tgacagtgtc tcaggggcag ccggtgaagc      420

tcaactgcag tgtggagggg atggaggagc ctgacatcca gtgggtgaag gatggggctg      480

tggtccagaa cttggaccag ttgtacatcc cagtcagcga gcagcactgg atcggcttcc      540

tcagcctgaa gtcagtggag cgctctgacg ccggccggta ctggtgccag gtggaggatg      600

ggggtgaaac cgagatctcc cagccagtgt ggctcacggt agaaggtgtg ccatttttca      660

cagtggagcc aaaagatctg gcagtgccac ccaatgcccc tttccaactg tcttgtgagg      720

ctgtgggtcc ccctgaacct gttaccattg tctggtggag aggaactacg aagatcgggg      780

gacccgctcc ctctccatct gttttaaatg taacaggggt gacccagagc accatgtttt      840

cctgtgaagc tcacaaccta aaaggcctgg cctcttctcg cacagccact gttcaccttc      900

aagcactgcc tgcagccccc ttcaacatca ccgtgacaaa gctttccagc agcaacgcta      960

gtgtggcctg gatgccaggt gctgatggcc gagctctgct acagtcctgt acagttcagg     1020

tgacacaggc cccaggaggc tgggaagtcc tggctgttgt ggtccctgtg ccccccttta     1080

cctgcctgct ccgggacctg gtgcctgcca ccaactacag cctcagggtg cgctgtgcca     1140

atgccttggg gccctctccc tatgctgact gggtgccctt tcagaccaag ggtctagccc     1200

cagccagcgc tccccaaaac ctccatgcca tccgcacaga ttcaggcctc atcttggagt     1260

gggaagaagt gatccccgag gcccctttgg aaggccccct gggaccctac aaactgtcct     1320

gggttcaaga caatggaacc caggatgagc tgacagtgga ggggaccagg gccaatttga     1380

caggctggga tccccaaaag gacctgatcg tacgtgtgtg cgtctccaat gcagttggct     1440

gtggaccctg gagtcagcca ctggtggtct cttctcatga ccgtgcaggc cagcagggcc     1500

ctcctcacag ccgcacatcc tgggtacctg tggtccttgg tgtgctaacg gccctggtga     1560

cggctgctgc cctggccctc atcctgcttc gaaagagacg gaaagagacg cggtttgggc     1620

aagcctttga cagtgtcatg gcccggggag agccagccgt tcacttccgg gcagcccggt     1680

ccttcaatcg agaaaggccc gagcgcatcg aggccacatt ggacagcttg ggcatcagcg     1740

atgaactaaa ggaaaaactg gaggatgtgc tcatcccaga gcagcagttc accctgggcc     1800

ggatgttggg caaaggagag tttggttcag tgcgggaggc ccagctgaag caagaggatg     1860

gctcctttgt gaaagtggct gtgaagatgc tgaaagctga catcattgcc tcaagcgaca     1920

ttgaagagtt cctcagggaa gcagcttgca tgaaggagtt tgaccatcca cacgtggcca     1980

aacttgttgg ggtaagcctc cggagcaggg ctaaaggccg tctccccatc cccatggtca     2040

tcttgccctt catgaagcat ggggacctgc atgccttcct gctcgcctcc cggattgggg     2100

agaacccctt taacctaccc ctccagaccc tgatccggtt catggtggac attgcctgcg     2160

gcatggagta cctgagctct cggaacttca tccaccgaga cctggctgct cggaattgca     2220

tgctggcaga ggacatgaca gtgtgtgtgg ctgacttcgg actctcccgg aagatctaca     2280

gtggggacta ctatcgtcaa ggctgtgcct ccaaactgcc tgtcaagtgg ctggccctgg     2340

agagcctggc cgacaacctg tatactgtgc agagtgacgt gtgggcgttc ggggtgacca     2400

tgtgggagat catgacacgt gggcagacgc catatgctgg catcgaaaac gctgagattt     2460

acaactacct cattggcggg aaccgcctga aacagcctcc ggagtgtatg gaggacgtgt     2520

atgatctcat gtaccagtgc tggagtgctg accccaagca gcgcccgagc tttacttgtc     2580

tgcgaatgga actggagaac atcttgggcc agctgtctgt gctatctgcc agccaggacc     2640

ccttatacat caacatcgag agagctgagg agcccactgc gggaggcagc ctggagctac     2700

ctggcaggga tcagccctac agtggggctg gggatggcag tggcatgggg gcagtgggtg     2760

gcactcccag tgactgtcgg tacatactca cccccggagg gctggctgag cagccagggc     2820

aggcagagca ccagccagag agtcccctca atgagacaca gaggcttttg ctgctgcagc     2880

aagggctact gccacacagt agctgttagc ccacaggcag agggcatcgg ggccatttgg     2940

ccggctctgg tggccactga gctggctgac taagccccgt ctgaccccag cccagacagc     3000

aaggtgtgga ggctcctgtg gtagtcctcc caagctgtgc tgggaagccc ggactgacca     3060

aatcacccaa tcccagttct tcctgcaacc actctgtggc cagcctggca tcagtttagg     3120

ccttggcttg atggaagtgg gccagtcctg gttgtctgaa cccaggcagc tggcaggagt     3180

ggggtggtta tgtttccatg gttaccatgg gtgtggatgg cagtgtgggg agggcaggtc     3240

cagctctgtg ggccctaccc tcctgctgag ctgcccctgc tgcttaagtg catgcattga     3300

gctgcctcca gcctggtggc ccagctatta ccacacttgg ggtttaaata tccaggtgtg     3360

cccctccaag tcacaaagag atgtccttgt aatattccct tttaggtgag ggttggtaag     3420

gggttggtat ctcaggtctg aatcttcacc atctttctga ttccgcaccc tgcctacgcc     3480

aggagaagtt gaggggagca tgcttccctg cagctgaccg ggtcacacaa aggcatgctg     3540

gagtacccag cctatcaggt gcccctcttc caaaggcagc gtgccgagcc agcaagagga     3600

aggggtgctg tgaggcttgc ccaggagcaa gtgaggccgg agaggagttc aggaaccctt     3660

ctccataccc acaatctgag cacgctacca aatctcaaaa tatcctaaga ctaacaaagg     3720

cagctgtgtc tgagcccaac ccttctaaac ggtgaccttt agtgccaact tcccctctaa     3780

ctggacagcc tcttctgtcc caagtctcca gagagaaatc aggcctgatg agggggaatt     3840

cctggaacct ggaccccagc cttggtgggg gagcctctgg aatgcatggg gcgggtccta     3900

gctgttaggg acatttccaa gctgttagtt gctgtttaaa atagaaataa aattgaagac     3960

taaagaccta aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                         4001


<210>  20
<211>  885
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys 
1               5                   10                  15      


Leu Ala Leu Cys Gly Trp Ala Cys Met Ala Pro Arg Gly Thr Gln Ala 
            20                  25                  30          


Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg 
        35                  40                  45              


Gly Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro 
    50                  55                  60                  


Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp 
65                  70                  75                  80  


Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp 
                85                  90                  95      


Ile Val Val Ser Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr 
            100                 105                 110         


Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser 
        115                 120                 125             


Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu 
    130                 135                 140                 


Pro Glu Asp Arg Thr Val Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys 
145                 150                 155                 160 


Gln Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp 
                165                 170                 175     


Ala Val Pro Leu Ala Thr Ala Pro Gly His Gly Pro Gln Arg Ser Leu 
            180                 185                 190         


His Val Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His 
        195                 200                 205             


Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu 
    210                 215                 220                 


Pro Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu 
225                 230                 235                 240 


Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr 
                245                 250                 255     


His Cys Thr Leu Gln Ala Val Leu Ser Asp Asp Gly Met Gly Ile Gln 
            260                 265                 270         


Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser 
        275                 280                 285             


Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro 
    290                 295                 300                 


Tyr His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp 
305                 310                 315                 320 


Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Val Pro Leu Gly Pro 
                325                 330                 335     


Pro Glu Asn Ile Ser Ala Thr Arg Asn Gly Ser Gln Ala Phe Val His 
            340                 345                 350         


Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg 
        355                 360                 365             


Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly 
    370                 375                 380                 


Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly Asp Gly Ser Val Ser 
385                 390                 395                 400 


Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro 
                405                 410                 415     


Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Val Lys Glu Pro 
            420                 425                 430         


Ser Thr Pro Ala Phe Ser Trp Pro Trp Trp Tyr Val Leu Leu Gly Ala 
        435                 440                 445             


Val Val Ala Ala Ala Cys Val Leu Ile Leu Ala Leu Phe Leu Val His 
    450                 455                 460                 


Arg Arg Lys Lys Glu Thr Arg Tyr Gly Glu Val Phe Glu Pro Thr Val 
465                 470                 475                 480 


Glu Arg Gly Glu Leu Val Val Arg Tyr Arg Val Arg Lys Ser Tyr Ser 
                485                 490                 495     


Arg Arg Thr Thr Glu Ala Thr Leu Asn Ser Leu Gly Ile Ser Glu Glu 
            500                 505                 510         


Leu Lys Glu Lys Leu Arg Asp Val Met Val Asp Arg His Lys Val Ala 
        515                 520                 525             


Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly Ala Val Met Glu Gly 
    530                 535                 540                 


Gln Leu Asn Gln Asp Asp Ser Ile Leu Lys Val Ala Val Lys Thr Met 
545                 550                 555                 560 


Lys Ile Ala Ile Cys Thr Arg Ser Glu Leu Glu Asp Phe Leu Ser Glu 
                565                 570                 575     


Ala Val Cys Met Lys Glu Phe Asp His Pro Asn Val Met Arg Leu Ile 
            580                 585                 590         


Gly Val Cys Phe Gln Gly Ser Glu Arg Glu Ser Phe Pro Ala Pro Val 
        595                 600                 605             


Val Ile Leu Pro Phe Met Lys His Gly Asp Leu His Ser Phe Leu Leu 
    610                 615                 620                 


Tyr Ser Arg Leu Gly Asp Gln Pro Val Tyr Leu Pro Thr Gln Met Leu 
625                 630                 635                 640 


Val Lys Phe Met Ala Asp Ile Ala Ser Gly Met Glu Tyr Leu Ser Thr 
                645                 650                 655     


Lys Arg Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Asn 
            660                 665                 670         


Glu Asn Met Ser Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys Ile 
        675                 680                 685             


Tyr Asn Gly Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro Val 
    690                 695                 700                 


Lys Trp Ile Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys 
705                 710                 715                 720 


Ser Asp Val Trp Ser Phe Gly Val Thr Met Trp Glu Ile Ala Thr Arg 
                725                 730                 735     


Gly Gln Thr Pro Tyr Pro Gly Val Glu Asn Ser Glu Ile Tyr Asp Tyr 
            740                 745                 750         


Leu Arg Gln Gly Asn Arg Leu Lys Gln Pro Ala Asp Cys Leu Asp Gly 
        755                 760                 765             


Leu Tyr Ala Leu Met Ser Arg Cys Trp Glu Leu Asn Pro Gln Asp Arg 
    770                 775                 780                 


Pro Ser Phe Thr Glu Leu Arg Glu Asp Leu Glu Asn Thr Leu Lys Ala 
785                 790                 795                 800 


Leu Pro Pro Ala Gln Glu Pro Asp Glu Ile Leu Tyr Val Asn Met Asp 
                805                 810                 815     


Glu Gly Gly Gly Tyr Pro Glu Pro Pro Gly Ala Ala Gly Gly Ala Asp 
            820                 825                 830         


Pro Pro Thr Gln Pro Asp Pro Lys Asp Ser Cys Ser Cys Leu Thr Ala 
        835                 840                 845             


Ala Glu Val His Pro Ala Gly Arg Tyr Val Leu Cys Pro Ser Thr Thr 
    850                 855                 860                 


Pro Ser Pro Ala Gln Pro Ala Asp Arg Gly Ser Pro Ala Ala Pro Gly 
865                 870                 875                 880 


Gln Glu Asp Gly Ala 
                885 


<210>  21
<211>  894
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys 
1               5                   10                  15      


Leu Ala Leu Cys Gly Trp Ala Cys Met Ala Pro Arg Gly Thr Gln Ala 
            20                  25                  30          


Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg 
        35                  40                  45              


Gly Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro 
    50                  55                  60                  


Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp 
65                  70                  75                  80  


Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp 
                85                  90                  95      


Ile Val Val Ser Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr 
            100                 105                 110         


Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser 
        115                 120                 125             


Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu 
    130                 135                 140                 


Pro Glu Asp Arg Thr Val Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys 
145                 150                 155                 160 


Gln Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp 
                165                 170                 175     


Ala Val Pro Leu Ala Thr Ala Pro Gly His Gly Pro Gln Arg Ser Leu 
            180                 185                 190         


His Val Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His 
        195                 200                 205             


Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu 
    210                 215                 220                 


Pro Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu 
225                 230                 235                 240 


Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr 
                245                 250                 255     


His Cys Thr Leu Gln Ala Val Leu Ser Asp Asp Gly Met Gly Ile Gln 
            260                 265                 270         


Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser 
        275                 280                 285             


Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro 
    290                 295                 300                 


Tyr His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp 
305                 310                 315                 320 


Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Val Pro Leu Gly Pro 
                325                 330                 335     


Pro Glu Asn Ile Ser Ala Thr Arg Asn Gly Ser Gln Ala Phe Val His 
            340                 345                 350         


Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg 
        355                 360                 365             


Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly 
    370                 375                 380                 


Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly Asp Gly Ser Val Ser 
385                 390                 395                 400 


Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro 
                405                 410                 415     


Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Gly Gln Ala Gln 
            420                 425                 430         


Pro Val His Gln Leu Val Lys Glu Pro Ser Thr Pro Ala Phe Ser Trp 
        435                 440                 445             


Pro Trp Trp Tyr Val Leu Leu Gly Ala Val Val Ala Ala Ala Cys Val 
    450                 455                 460                 


Leu Ile Leu Ala Leu Phe Leu Val His Arg Arg Lys Lys Glu Thr Arg 
465                 470                 475                 480 


Tyr Gly Glu Val Phe Glu Pro Thr Val Glu Arg Gly Glu Leu Val Val 
                485                 490                 495     


Arg Tyr Arg Val Arg Lys Ser Tyr Ser Arg Arg Thr Thr Glu Ala Thr 
            500                 505                 510         


Leu Asn Ser Leu Gly Ile Ser Glu Glu Leu Lys Glu Lys Leu Arg Asp 
        515                 520                 525             


Val Met Val Asp Arg His Lys Val Ala Leu Gly Lys Thr Leu Gly Glu 
    530                 535                 540                 


Gly Glu Phe Gly Ala Val Met Glu Gly Gln Leu Asn Gln Asp Asp Ser 
545                 550                 555                 560 


Ile Leu Lys Val Ala Val Lys Thr Met Lys Ile Ala Ile Cys Thr Arg 
                565                 570                 575     


Ser Glu Leu Glu Asp Phe Leu Ser Glu Ala Val Cys Met Lys Glu Phe 
            580                 585                 590         


Asp His Pro Asn Val Met Arg Leu Ile Gly Val Cys Phe Gln Gly Ser 
        595                 600                 605             


Glu Arg Glu Ser Phe Pro Ala Pro Val Val Ile Leu Pro Phe Met Lys 
    610                 615                 620                 


His Gly Asp Leu His Ser Phe Leu Leu Tyr Ser Arg Leu Gly Asp Gln 
625                 630                 635                 640 


Pro Val Tyr Leu Pro Thr Gln Met Leu Val Lys Phe Met Ala Asp Ile 
                645                 650                 655     


Ala Ser Gly Met Glu Tyr Leu Ser Thr Lys Arg Phe Ile His Arg Asp 
            660                 665                 670         


Leu Ala Ala Arg Asn Cys Met Leu Asn Glu Asn Met Ser Val Cys Val 
        675                 680                 685             


Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg 
    690                 695                 700                 


Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile Ala Ile Glu Ser 
705                 710                 715                 720 


Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val Trp Ser Phe Gly 
                725                 730                 735     


Val Thr Met Trp Glu Ile Ala Thr Arg Gly Gln Thr Pro Tyr Pro Gly 
            740                 745                 750         


Val Glu Asn Ser Glu Ile Tyr Asp Tyr Leu Arg Gln Gly Asn Arg Leu 
        755                 760                 765             


Lys Gln Pro Ala Asp Cys Leu Asp Gly Leu Tyr Ala Leu Met Ser Arg 
    770                 775                 780                 


Cys Trp Glu Leu Asn Pro Gln Asp Arg Pro Ser Phe Thr Glu Leu Arg 
785                 790                 795                 800 


Glu Asp Leu Glu Asn Thr Leu Lys Ala Leu Pro Pro Ala Gln Glu Pro 
                805                 810                 815     


Asp Glu Ile Leu Tyr Val Asn Met Asp Glu Gly Gly Gly Tyr Pro Glu 
            820                 825                 830         


Pro Pro Gly Ala Ala Gly Gly Ala Asp Pro Pro Thr Gln Pro Asp Pro 
        835                 840                 845             


Lys Asp Ser Cys Ser Cys Leu Thr Ala Ala Glu Val His Pro Ala Gly 
    850                 855                 860                 


Arg Tyr Val Leu Cys Pro Ser Thr Thr Pro Ser Pro Ala Gln Pro Ala 
865                 870                 875                 880 


Asp Arg Gly Ser Pro Ala Ala Pro Gly Gln Glu Asp Gly Ala 
                885                 890                 


<210>  22
<211>  4743
<212>  DNA
<213>  Homo sapiens

<400>  22
gggaaggagg caggggtgct gagaaggcgg ctgctgggca gagccggtgg caagggcctc       60

ccctgccgct gtgccaggca ggcagtgcca aatccgggga gcctggagct ggggggaggg      120

ccggggacag cccggccctg ccccctcccc cgctgggagc ccaacaactt ctgaggaaag      180

tttggcaccc atggcgtggc ggtgccccag gatgggcagg gtcccgctgg cctggtgctt      240

ggcgctgtgc ggctgggcgt gcatggcccc caggggcacg caggctgaag aaagtccctt      300

cgtgggcaac ccagggaata tcacaggtgc ccggggactc acgggcaccc ttcggtgtca      360

gctccaggtt cagggagagc cccccgaggt acattggctt cgggatggac agatcctgga      420

gctcgcggac agcacccaga cccaggtgcc cctgggtgag gatgaacagg atgactggat      480

agtggtcagc cagctcagaa tcacctccct gcagctttcc gacacgggac agtaccagtg      540

tttggtgttt ctgggacatc agaccttcgt gtcccagcct ggctatgttg ggctggaggg      600

cttgccttac ttcctggagg agcccgaaga caggactgtg gccgccaaca cccccttcaa      660

cctgagctgc caagctcagg gacccccaga gcccgtggac ctactctggc tccaggatgc      720

tgtccccctg gccacggctc caggtcacgg cccccagcgc agcctgcatg ttccagggct      780

gaacaagaca tcctctttct cctgcgaagc ccataacgcc aagggggtca ccacatcccg      840

cacagccacc atcacagtgc tcccccagca gccccgtaac ctccacctgg tctcccgcca      900

acccacggag ctggaggtgg cttggactcc aggcctgagc ggcatctacc ccctgaccca      960

ctgcaccctg caggctgtgc tgtcagacga tgggatgggc atccaggcgg gagaaccaga     1020

ccccccagag gagcccctca cctcgcaagc atccgtgccc ccccatcagc ttcggctagg     1080

cagcctccat cctcacaccc cttatcacat ccgcgtggca tgcaccagca gccagggccc     1140

ctcatcctgg acccactggc ttcctgtgga gacgccggag ggagtgcccc tgggcccccc     1200

tgagaacatt agtgctacgc ggaatgggag ccaggccttc gtgcattggc aagagccccg     1260

ggcgcccctg cagggtaccc tgttagggta ccggctggcg tatcaaggcc aggacacccc     1320

agaggtgcta atggacatag ggctaaggca agaggtgacc ctggagctgc agggggacgg     1380

gtctgtgtcc aatctgacag tgtgtgtggc agcctacact gctgctgggg atggaccctg     1440

gagcctccca gtacccctgg aggcctggcg cccagggcaa gcacagccag tccaccagct     1500

ggtgaaggaa ccttcaactc ctgccttctc gtggccctgg tggtatgtac tgctaggagc     1560

agtcgtggcc gctgcctgtg tcctcatctt ggctctcttc cttgtccacc ggcgaaagaa     1620

ggagacccgt tatggagaag tgtttgaacc aacagtggaa agaggtgaac tggtagtcag     1680

gtaccgcgtg cgcaagtcct acagtcgtcg gaccactgaa gctaccttga acagcctggg     1740

catcagtgaa gagctgaagg agaagctgcg ggatgtgatg gtggaccggc acaaggtggc     1800

cctggggaag actctgggag agggagagtt tggagctgtg atggaaggcc agctcaacca     1860

ggacgactcc atcctcaagg tggctgtgaa gacgatgaag attgccatct gcacgaggtc     1920

agagctggag gatttcctga gtgaagcggt ctgcatgaag gaatttgacc atcccaacgt     1980

catgaggctc atcggtgtct gtttccaggg ttctgaacga gagagcttcc cagcacctgt     2040

ggtcatctta cctttcatga aacatggaga cctacacagc ttcctcctct attcccggct     2100

cggggaccag ccagtgtacc tgcccactca gatgctagtg aagttcatgg cagacatcgc     2160

cagtggcatg gagtatctga gtaccaagag attcatacac cgggacctgg cggccaggaa     2220

ctgcatgctg aatgagaaca tgtccgtgtg tgtggcggac ttcgggctct ccaagaagat     2280

ctacaatggg gactactacc gccagggacg tatcgccaag atgccagtca agtggattgc     2340

cattgagagt ctagctgacc gtgtctacac cagcaagagc gatgtgtggt ccttcggggt     2400

gacaatgtgg gagattgcca caagaggcca aaccccatat ccgggcgtgg agaacagcga     2460

gatttatgac tatctgcgcc agggaaatcg cctgaagcag cctgcggact gtctggatgg     2520

actgtatgcc ttgatgtcgc ggtgctggga gctaaatccc caggaccggc caagttttac     2580

agagctgcgg gaagatttgg agaacacact gaaggccttg cctcctgccc aggagcctga     2640

cgaaatcctc tatgtcaaca tggatgaggg tggaggttat cctgaacccc ctggagctgc     2700

aggaggagct gaccccccaa cccagccaga ccctaaggat tcctgtagct gcctcactgc     2760

ggctgaggtc catcctgctg gacgctatgt cctctgccct tccacaaccc ctagccccgc     2820

tcagcctgct gataggggct ccccagcagc cccagggcag gaggatggtg cctgagacaa     2880

ccctccacct ggtactccct ctcaggatcc aagctaagca ctgccactgg ggaaaactcc     2940

accttcccac tttcccaccc cacgccttat ccccacttgc agccctgtct tcctacctat     3000

cccacctcca tcccagacag gtccctcccc ttctctgtgc agtagcatca ccttgaaagc     3060

agtagcatca ccatctgtaa aaggaagggg ttggattgca atatctgaag ccctcccagg     3120

tgttaacatt ccaagactct agagtccaag gtttaaagag tctagattca aaggttctag     3180

gtttcaaaga tgctgtgagt ctttggttct aaggacctga aattccaaag tctctaattc     3240

tattaaagtg ctaaggttct aaggcctact tttttttttt tttttttttt tttttttttt     3300

gcgatagagt ctcactgtgt cacccaggct ggagtgcagt ggtgcaatct cgcctcactg     3360

caaccttcac ctaccgagtt caagtgattt tcctgccttg gcctcccaag tagctgggat     3420

tacaggtgtg tgccaccaca cccggctaat ttttatattt ttagtagaga cagggtttca     3480

ccatgttggc caggctggtc taaaactcct gacctcaagt gatctgccca cctcagcctc     3540

ccaaagtgct gagattacag gcatgagcca ctgcactcaa ccttaagacc tactgttcta     3600

aagctctgac attatgtggt tttagatttt ctggttctaa catttttgat aaagcctcaa     3660

ggttttaggt tctaaagttc taagattctg attttaggag ctaaggctct atgagtctag     3720

atgtttattc ttctagagtt cagagtcctt aaaatgtaag attatagatt ctaaagattc     3780

tatagttcta gacatggagg ttctaaggcc taggattcta aaatgtgatg ttctaaggct     3840

ctgagagtct agattctctg gctgtaaggc tctagatcat aaggcttcaa aatgttatct     3900

tctcaagttc taagattcta atgatgatca attatagttt ctgaggcttt atgataatag     3960

attctcttgt ataagatcct agatcctaag ggtcgaaagc tctagaatct gcaattcaaa     4020

agttccaaga gtctaaagat ggagtttcta aggtccggtg ttctaagatg tgatattcta     4080

agacttactc taagatctta gattctctgt gtctaagatt ctagatcaga tgctccaaga     4140

ttctagatga ttaaataaga ttctaacggt ctgttctgtt tcaaggcact ctagattcca     4200

ttggtccaag attccggatc ctaagcatct aagttataag actctcacac tcagttgtga     4260

ctaactagac accaaagttc taataatttc taatgttgga cacctttagg ttctttgctg     4320

cattctgcct ctctaggacc atggttaaga gtccaagaat ccacatttct aaaatcttat     4380

agttctaggc actgtagttc taagactcaa atgttctaag tttctaagat tctaaaggtc     4440

cacaggtcta gactattagg tgcaatttca aggttctaac cctatactgt agtattcttt     4500

ggggtgcccc tctccttctt agctatcatt gcttcctcct ccccaactgt gggggtgtgc     4560

ccccttcaag cctgtgcaat gcattaggga tgcctccttt cccgcagggg atggacgatc     4620

tcccaccttt cgggccatgt tgcccccgtg agccaatccc tcaccttctg agtacagagt     4680

gtggactctg gtgcctccag aggggctcag gtcacataaa actttgtata tcaacgaaaa     4740

aaa                                                                   4743


<210>  23
<211>  4716
<212>  DNA
<213>  Homo sapiens

<400>  23
gggaaggagg caggggtgct gagaaggcgg ctgctgggca gagccggtgg caagggcctc       60

ccctgccgct gtgccaggca ggcagtgcca aatccgggga gcctggagct ggggggaggg      120

ccggggacag cccggccctg ccccctcccc cgctgggagc ccaacaactt ctgaggaaag      180

tttggcaccc atggcgtggc ggtgccccag gatgggcagg gtcccgctgg cctggtgctt      240

ggcgctgtgc ggctgggcgt gcatggcccc caggggcacg caggctgaag aaagtccctt      300

cgtgggcaac ccagggaata tcacaggtgc ccggggactc acgggcaccc ttcggtgtca      360

gctccaggtt cagggagagc cccccgaggt acattggctt cgggatggac agatcctgga      420

gctcgcggac agcacccaga cccaggtgcc cctgggtgag gatgaacagg atgactggat      480

agtggtcagc cagctcagaa tcacctccct gcagctttcc gacacgggac agtaccagtg      540

tttggtgttt ctgggacatc agaccttcgt gtcccagcct ggctatgttg ggctggaggg      600

cttgccttac ttcctggagg agcccgaaga caggactgtg gccgccaaca cccccttcaa      660

cctgagctgc caagctcagg gacccccaga gcccgtggac ctactctggc tccaggatgc      720

tgtccccctg gccacggctc caggtcacgg cccccagcgc agcctgcatg ttccagggct      780

gaacaagaca tcctctttct cctgcgaagc ccataacgcc aagggggtca ccacatcccg      840

cacagccacc atcacagtgc tcccccagca gccccgtaac ctccacctgg tctcccgcca      900

acccacggag ctggaggtgg cttggactcc aggcctgagc ggcatctacc ccctgaccca      960

ctgcaccctg caggctgtgc tgtcagacga tgggatgggc atccaggcgg gagaaccaga     1020

ccccccagag gagcccctca cctcgcaagc atccgtgccc ccccatcagc ttcggctagg     1080

cagcctccat cctcacaccc cttatcacat ccgcgtggca tgcaccagca gccagggccc     1140

ctcatcctgg acccactggc ttcctgtgga gacgccggag ggagtgcccc tgggcccccc     1200

tgagaacatt agtgctacgc ggaatgggag ccaggccttc gtgcattggc aagagccccg     1260

ggcgcccctg cagggtaccc tgttagggta ccggctggcg tatcaaggcc aggacacccc     1320

agaggtgcta atggacatag ggctaaggca agaggtgacc ctggagctgc agggggacgg     1380

gtctgtgtcc aatctgacag tgtgtgtggc agcctacact gctgctgggg atggaccctg     1440

gagcctccca gtacccctgg aggcctggcg cccagtgaag gaaccttcaa ctcctgcctt     1500

ctcgtggccc tggtggtatg tactgctagg agcagtcgtg gccgctgcct gtgtcctcat     1560

cttggctctc ttccttgtcc accggcgaaa gaaggagacc cgttatggag aagtgtttga     1620

accaacagtg gaaagaggtg aactggtagt caggtaccgc gtgcgcaagt cctacagtcg     1680

tcggaccact gaagctacct tgaacagcct gggcatcagt gaagagctga aggagaagct     1740

gcgggatgtg atggtggacc ggcacaaggt ggccctgggg aagactctgg gagagggaga     1800

gtttggagct gtgatggaag gccagctcaa ccaggacgac tccatcctca aggtggctgt     1860

gaagacgatg aagattgcca tctgcacgag gtcagagctg gaggatttcc tgagtgaagc     1920

ggtctgcatg aaggaatttg accatcccaa cgtcatgagg ctcatcggtg tctgtttcca     1980

gggttctgaa cgagagagct tcccagcacc tgtggtcatc ttacctttca tgaaacatgg     2040

agacctacac agcttcctcc tctattcccg gctcggggac cagccagtgt acctgcccac     2100

tcagatgcta gtgaagttca tggcagacat cgccagtggc atggagtatc tgagtaccaa     2160

gagattcata caccgggacc tggcggccag gaactgcatg ctgaatgaga acatgtccgt     2220

gtgtgtggcg gacttcgggc tctccaagaa gatctacaat ggggactact accgccaggg     2280

acgtatcgcc aagatgccag tcaagtggat tgccattgag agtctagctg accgtgtcta     2340

caccagcaag agcgatgtgt ggtccttcgg ggtgacaatg tgggagattg ccacaagagg     2400

ccaaacccca tatccgggcg tggagaacag cgagatttat gactatctgc gccagggaaa     2460

tcgcctgaag cagcctgcgg actgtctgga tggactgtat gccttgatgt cgcggtgctg     2520

ggagctaaat ccccaggacc ggccaagttt tacagagctg cgggaagatt tggagaacac     2580

actgaaggcc ttgcctcctg cccaggagcc tgacgaaatc ctctatgtca acatggatga     2640

gggtggaggt tatcctgaac cccctggagc tgcaggagga gctgaccccc caacccagcc     2700

agaccctaag gattcctgta gctgcctcac tgcggctgag gtccatcctg ctggacgcta     2760

tgtcctctgc ccttccacaa cccctagccc cgctcagcct gctgataggg gctccccagc     2820

agccccaggg caggaggatg gtgcctgaga caaccctcca cctggtactc cctctcagga     2880

tccaagctaa gcactgccac tggggaaaac tccaccttcc cactttccca ccccacgcct     2940

tatccccact tgcagccctg tcttcctacc tatcccacct ccatcccaga caggtccctc     3000

cccttctctg tgcagtagca tcaccttgaa agcagtagca tcaccatctg taaaaggaag     3060

gggttggatt gcaatatctg aagccctccc aggtgttaac attccaagac tctagagtcc     3120

aaggtttaaa gagtctagat tcaaaggttc taggtttcaa agatgctgtg agtctttggt     3180

tctaaggacc tgaaattcca aagtctctaa ttctattaaa gtgctaaggt tctaaggcct     3240

actttttttt tttttttttt tttttttttt tttgcgatag agtctcactg tgtcacccag     3300

gctggagtgc agtggtgcaa tctcgcctca ctgcaacctt cacctaccga gttcaagtga     3360

ttttcctgcc ttggcctccc aagtagctgg gattacaggt gtgtgccacc acacccggct     3420

aatttttata tttttagtag agacagggtt tcaccatgtt ggccaggctg gtctaaaact     3480

cctgacctca agtgatctgc ccacctcagc ctcccaaagt gctgagatta caggcatgag     3540

ccactgcact caaccttaag acctactgtt ctaaagctct gacattatgt ggttttagat     3600

tttctggttc taacattttt gataaagcct caaggtttta ggttctaaag ttctaagatt     3660

ctgattttag gagctaaggc tctatgagtc tagatgttta ttcttctaga gttcagagtc     3720

cttaaaatgt aagattatag attctaaaga ttctatagtt ctagacatgg aggttctaag     3780

gcctaggatt ctaaaatgtg atgttctaag gctctgagag tctagattct ctggctgtaa     3840

ggctctagat cataaggctt caaaatgtta tcttctcaag ttctaagatt ctaatgatga     3900

tcaattatag tttctgaggc tttatgataa tagattctct tgtataagat cctagatcct     3960

aagggtcgaa agctctagaa tctgcaattc aaaagttcca agagtctaaa gatggagttt     4020

ctaaggtccg gtgttctaag atgtgatatt ctaagactta ctctaagatc ttagattctc     4080

tgtgtctaag attctagatc agatgctcca agattctaga tgattaaata agattctaac     4140

ggtctgttct gtttcaaggc actctagatt ccattggtcc aagattccgg atcctaagca     4200

tctaagttat aagactctca cactcagttg tgactaacta gacaccaaag ttctaataat     4260

ttctaatgtt ggacaccttt aggttctttg ctgcattctg cctctctagg accatggtta     4320

agagtccaag aatccacatt tctaaaatct tatagttcta ggcactgtag ttctaagact     4380

caaatgttct aagtttctaa gattctaaag gtccacaggt ctagactatt aggtgcaatt     4440

tcaaggttct aaccctatac tgtagtattc tttggggtgc ccctctcctt cttagctatc     4500

attgcttcct cctccccaac tgtgggggtg tgcccccttc aagcctgtgc aatgcattag     4560

ggatgcctcc tttcccgcag gggatggacg atctcccacc tttcgggcca tgttgccccc     4620

gtgagccaat ccctcacctt ctgagtacag agtgtggact ctggtgcctc cagaggggct     4680

caggtcacat aaaactttgt atatcaacga aaaaaa                               4716


<210>  24
<211>  999
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Gly Pro Ala Pro Leu Pro Leu Leu Leu Gly Leu Phe Leu Pro Ala 
1               5                   10                  15      


Leu Trp Arg Arg Ala Ile Thr Glu Ala Arg Glu Glu Ala Lys Pro Tyr 
            20                  25                  30          


Pro Leu Phe Pro Gly Pro Phe Pro Gly Ser Leu Gln Thr Asp His Thr 
        35                  40                  45              


Pro Leu Leu Ser Leu Pro His Ala Ser Gly Tyr Gln Pro Ala Leu Met 
    50                  55                  60                  


Phe Ser Pro Thr Gln Pro Gly Arg Pro His Thr Gly Asn Val Ala Ile 
65                  70                  75                  80  


Pro Gln Val Thr Ser Val Glu Ser Lys Pro Leu Pro Pro Leu Ala Phe 
                85                  90                  95      


Lys His Thr Val Gly His Ile Ile Leu Ser Glu His Lys Gly Val Lys 
            100                 105                 110         


Phe Asn Cys Ser Ile Ser Val Pro Asn Ile Tyr Gln Asp Thr Thr Ile 
        115                 120                 125             


Ser Trp Trp Lys Asp Gly Lys Glu Leu Leu Gly Ala His His Ala Ile 
    130                 135                 140                 


Thr Gln Phe Tyr Pro Asp Asp Glu Val Thr Ala Ile Ile Ala Ser Phe 
145                 150                 155                 160 


Ser Ile Thr Ser Val Gln Arg Ser Asp Asn Gly Ser Tyr Ile Cys Lys 
                165                 170                 175     


Met Lys Ile Asn Asn Glu Glu Ile Val Ser Asp Pro Ile Tyr Ile Glu 
            180                 185                 190         


Val Gln Gly Leu Pro His Phe Thr Lys Gln Pro Glu Ser Met Asn Val 
        195                 200                 205             


Thr Arg Asn Thr Ala Phe Asn Leu Thr Cys Gln Ala Val Gly Pro Pro 
    210                 215                 220                 


Glu Pro Val Asn Ile Phe Trp Val Gln Asn Ser Ser Arg Val Asn Glu 
225                 230                 235                 240 


Gln Pro Glu Lys Ser Pro Ser Val Leu Thr Val Pro Gly Leu Thr Glu 
                245                 250                 255     


Met Ala Val Phe Ser Cys Glu Ala His Asn Asp Lys Gly Leu Thr Val 
            260                 265                 270         


Ser Lys Gly Val Gln Ile Asn Ile Lys Ala Ile Pro Ser Pro Pro Thr 
        275                 280                 285             


Glu Val Ser Ile Arg Asn Ser Thr Ala His Ser Ile Leu Ile Ser Trp 
    290                 295                 300                 


Val Pro Gly Phe Asp Gly Tyr Ser Pro Phe Arg Asn Cys Ser Ile Gln 
305                 310                 315                 320 


Val Lys Glu Ala Asp Pro Leu Ser Asn Gly Ser Val Met Ile Phe Asn 
                325                 330                 335     


Thr Ser Ala Leu Pro His Leu Tyr Gln Ile Lys Gln Leu Gln Ala Leu 
            340                 345                 350         


Ala Asn Tyr Ser Ile Gly Val Ser Cys Met Asn Glu Ile Gly Trp Ser 
        355                 360                 365             


Ala Val Ser Pro Trp Ile Leu Ala Ser Thr Thr Glu Gly Ala Pro Ser 
    370                 375                 380                 


Val Ala Pro Leu Asn Val Thr Val Phe Leu Asn Glu Ser Ser Asp Asn 
385                 390                 395                 400 


Val Asp Ile Arg Trp Met Lys Pro Pro Thr Lys Gln Gln Asp Gly Glu 
                405                 410                 415     


Leu Val Gly Tyr Arg Ile Ser His Val Trp Gln Ser Ala Gly Ile Ser 
            420                 425                 430         


Lys Glu Leu Leu Glu Glu Val Gly Gln Asn Gly Ser Arg Ala Arg Ile 
        435                 440                 445             


Ser Val Gln Val His Asn Ala Thr Cys Thr Val Arg Ile Ala Ala Val 
    450                 455                 460                 


Thr Arg Gly Gly Val Gly Pro Phe Ser Asp Pro Val Lys Ile Phe Ile 
465                 470                 475                 480 


Pro Ala His Gly Trp Val Asp Tyr Ala Pro Ser Ser Thr Pro Ala Pro 
                485                 490                 495     


Gly Asn Ala Asp Pro Val Leu Ile Ile Phe Gly Cys Phe Cys Gly Phe 
            500                 505                 510         


Ile Leu Ile Gly Leu Ile Leu Tyr Ile Ser Leu Ala Ile Arg Lys Arg 
        515                 520                 525             


Val Gln Glu Thr Lys Phe Gly Asn Ala Phe Thr Glu Glu Asp Ser Glu 
    530                 535                 540                 


Leu Val Val Asn Tyr Ile Ala Lys Lys Ser Phe Cys Arg Arg Ala Ile 
545                 550                 555                 560 


Glu Leu Thr Leu His Ser Leu Gly Val Ser Glu Glu Leu Gln Asn Lys 
                565                 570                 575     


Leu Glu Asp Val Val Ile Asp Arg Asn Leu Leu Ile Leu Gly Lys Ile 
            580                 585                 590         


Leu Gly Glu Gly Glu Phe Gly Ser Val Met Glu Gly Asn Leu Lys Gln 
        595                 600                 605             


Glu Asp Gly Thr Ser Leu Lys Val Ala Val Lys Thr Met Lys Leu Asp 
    610                 615                 620                 


Asn Ser Ser Gln Arg Glu Ile Glu Glu Phe Leu Ser Glu Ala Ala Cys 
625                 630                 635                 640 


Met Lys Asp Phe Ser His Pro Asn Val Ile Arg Leu Leu Gly Val Cys 
                645                 650                 655     


Ile Glu Met Ser Ser Gln Gly Ile Pro Lys Pro Met Val Ile Leu Pro 
            660                 665                 670         


Phe Met Lys Tyr Gly Asp Leu His Thr Tyr Leu Leu Tyr Ser Arg Leu 
        675                 680                 685             


Glu Thr Gly Pro Lys His Ile Pro Leu Gln Thr Leu Leu Lys Phe Met 
    690                 695                 700                 


Val Asp Ile Ala Leu Gly Met Glu Tyr Leu Ser Asn Arg Asn Phe Leu 
705                 710                 715                 720 


His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Arg Asp Asp Met Thr 
                725                 730                 735     


Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Ser Gly Asp 
            740                 745                 750         


Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile Ala 
        755                 760                 765             


Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val Trp 
    770                 775                 780                 


Ala Phe Gly Val Thr Met Trp Glu Ile Ala Thr Arg Gly Met Thr Pro 
785                 790                 795                 800 


Tyr Pro Gly Val Gln Asn His Glu Met Tyr Asp Tyr Leu Leu His Gly 
                805                 810                 815     


His Arg Leu Lys Gln Pro Glu Asp Cys Leu Asp Glu Leu Tyr Glu Ile 
            820                 825                 830         


Met Tyr Ser Cys Trp Arg Thr Asp Pro Leu Asp Arg Pro Thr Phe Ser 
        835                 840                 845             


Val Leu Arg Leu Gln Leu Glu Lys Leu Leu Glu Ser Leu Pro Asp Val 
    850                 855                 860                 


Arg Asn Gln Ala Asp Val Ile Tyr Val Asn Thr Gln Leu Leu Glu Ser 
865                 870                 875                 880 


Ser Glu Gly Leu Ala Gln Gly Ser Thr Leu Ala Pro Leu Asp Leu Asn 
                885                 890                 895     


Ile Asp Pro Asp Ser Ile Ile Ala Ser Cys Thr Pro Arg Ala Ala Ile 
            900                 905                 910         


Ser Val Val Thr Ala Glu Val His Asp Ser Lys Pro His Glu Gly Arg 
        915                 920                 925             


Tyr Ile Leu Asn Gly Gly Ser Glu Glu Trp Glu Asp Leu Thr Ser Ala 
    930                 935                 940                 


Pro Ser Ala Ala Val Thr Ala Glu Lys Asn Ser Val Leu Pro Gly Glu 
945                 950                 955                 960 


Arg Leu Val Arg Asn Gly Val Ser Trp Ser His Ser Ser Met Leu Pro 
                965                 970                 975     


Leu Gly Ser Ser Leu Pro Asp Glu Leu Leu Phe Ala Asp Asp Ser Ser 
            980                 985                 990         


Glu Gly Ser Glu Val Leu Met 
        995                 


<210>  25
<211>  3632
<212>  DNA
<213>  Homo sapiens

<400>  25
actcactgcc cgggccgccc ggacagggag cttcgctggc gcgcttggcc ggcgacagga       60

caggttcggg acgtccatct gtccatccgt ccggagagaa attacagatc cgcagccccg      120

ggatggggcc ggccccgctg ccgctgctgc tgggcctctt cctccccgcg ctctggcgta      180

gagctatcac tgaggcaagg gaagaagcca agccttaccc gctattcccg ggaccttttc      240

cagggagcct gcaaactgac cacacaccgc tgttatccct tcctcacgcc agtgggtacc      300

agcctgcctt gatgttttca ccaacccagc ctggaagacc acatacagga aacgtagcca      360

ttccccaggt gacctctgtc gaatcaaagc ccctaccgcc tcttgccttc aaacacacag      420

ttggacacat aatactttct gaacataaag gtgtcaaatt taattgctca atcagtgtac      480

ctaatatata ccaggacacc acaatttctt ggtggaaaga tgggaaggaa ttgcttgggg      540

cacatcatgc aattacacag ttttatccag atgatgaagt tacagcaata atcgcttcct      600

tcagcataac cagtgtgcag cgttcagaca atgggtcgta tatctgtaag atgaaaataa      660

acaatgaaga gatcgtgtct gatcccatct acatcgaagt acaaggactt cctcacttta      720

ctaagcagcc tgagagcatg aatgtcacca gaaacacagc cttcaacctc acctgtcagg      780

ctgtgggccc gcctgagccc gtcaacattt tctgggttca aaacagtagc cgtgttaacg      840

aacagcctga aaaatccccc tccgtgctaa ctgttccagg cctgacggag atggcggtct      900

tcagttgtga ggcccacaat gacaaagggc tgaccgtgtc caagggagtg cagatcaaca      960

tcaaagcaat tccctcccca ccaactgaag tcagcatccg taacagcact gcacacagca     1020

ttctgatctc ctgggttcct ggttttgatg gatactcccc gttcaggaat tgcagcattc     1080

aggtcaagga agctgatccg ctgagtaatg gctcagtcat gatttttaac acctctgcct     1140

taccacatct gtaccaaatc aagcagctgc aagccctggc taattacagc attggtgttt     1200

cctgcatgaa tgaaataggc tggtctgcag tgagcccttg gattctagcc agcacgactg     1260

aaggagcccc atcagtagca cctttaaatg tcactgtgtt tctgaatgaa tctagtgata     1320

atgtggacat cagatggatg aagcctccga ctaagcagca ggatggagaa ctggtgggct     1380

accggatatc ccacgtgtgg cagagtgcag ggatttccaa agagctcttg gaggaagttg     1440

gccagaatgg cagccgagct cggatctctg ttcaagtcca caatgctacg tgcacagtga     1500

ggattgcagc cgtcaccaga gggggagttg ggcccttcag tgatccagtg aaaatattta     1560

tccctgcaca cggttgggta gattatgccc cctcttcaac tccggcgcct ggcaacgcag     1620

atcctgtgct catcatcttt ggctgctttt gtggatttat tttgattggg ttgattttat     1680

acatctcctt ggccatcaga aaaagagtcc aggagacaaa gtttgggaat gcattcacag     1740

aggaggattc tgaattagtg gtgaattata tagcaaagaa atccttctgt cggcgagcca     1800

ttgaacttac cttacatagc ttgggagtca gtgaggaact acaaaataaa ctagaagatg     1860

ttgtgattga caggaatctt ctaattcttg gaaaaattct gggtgaagga gagtttgggt     1920

ctgtaatgga aggaaatctt aagcaggaag atgggacctc tctgaaagtg gcagtgaaga     1980

ccatgaagtt ggacaactct tcacagcggg agatcgagga gtttctcagt gaggcagcgt     2040

gcatgaaaga cttcagccac ccaaatgtca ttcgacttct aggtgtgtgt atagaaatga     2100

gctctcaagg catcccaaag cccatggtaa ttttaccctt catgaaatac ggggacctgc     2160

atacttactt actttattcc cgattggaga caggaccaaa gcatattcct ctgcagacac     2220

tattgaagtt catggtggat attgccctgg gaatggagta tctgagcaac aggaattttc     2280

ttcatcgaga tttagctgct cgaaactgca tgttgcgaga tgacatgact gtctgtgttg     2340

cggacttcgg cctctctaag aagatttaca gtggcgatta ttaccgccaa ggccgcattg     2400

ctaagatgcc tgttaaatgg atcgccatag aaagtcttgc agaccgagtc tacacaagta     2460

aaagtgatgt gtgggcattt ggcgtgacca tgtgggaaat agctacgcgg ggaatgactc     2520

cctatcctgg ggtccagaac catgagatgt atgactatct tctccatggc cacaggttga     2580

agcagcccga agactgcctg gatgaactgt atgaaataat gtactcttgc tggagaaccg     2640

atcccttaga ccgccccacc ttttcagtat tgaggctgca gctagaaaaa ctcttagaaa     2700

gtttgcctga cgttcggaac caagcagacg ttatttacgt caatacacag ttgctggaga     2760

gctctgaggg cctggcccag ggctccaccc ttgctccact ggacttgaac atcgaccctg     2820

actctataat tgcctcctgc actccccgcg ctgccatcag tgtggtcaca gcagaagttc     2880

atgacagcaa acctcatgaa ggacggtaca tcctgaatgg gggcagtgag gaatgggaag     2940

atctgacttc tgccccctct gctgcagtca cagctgaaaa gaacagtgtt ttaccggggg     3000

agagacttgt taggaatggg gtctcctggt cccattcgag catgctgccc ttgggaagct     3060

cattgcccga tgaacttttg tttgctgacg actcctcaga aggctcagaa gtcctgatgt     3120

gaggagaggt gcggggagac attccaaaaa tcaagccaat tcttctgctg taggagaatc     3180

caattgtacc tgatgttttt ggtatttgtc ttccttacca agtgaactcc atggccccaa     3240

agcaccagat gaatgttgtt aagtaagctg tcattaaaaa tacataatat atatttattt     3300

aaagagaaaa aatatgtgta tatcatggaa aaagacaagg atattttaat aaaacattac     3360

ttatttcatt tcacttatct tgcatatctt aaaattaagc ttcagctgct ccttgatatt     3420

aacatttgta cagagttgaa gttgtttttt caagttcttt tctttttcat gactattaaa     3480

tgtaaaaata tttgtaaaat gaaatgccat atttgacttg gcttctggtc ttgatgtatt     3540

tgataagaat gattcattca atgtttaaag ttgtataact gattaatttt ctgatatggc     3600

ttcctaataa aatatgaata aggaagaaaa aa                                   3632


<210>  26
<211>  678
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Pro Ser Leu Ser Pro Gly Pro Ala Ala Leu Arg Arg Ala Pro 
1               5                   10                  15      


Gln Leu Leu Leu Leu Leu Leu Ala Ala Glu Cys Ala Leu Ala Ala Leu 
            20                  25                  30          


Leu Pro Ala Arg Glu Ala Thr Gln Phe Leu Arg Pro Arg Gln Arg Arg 
        35                  40                  45              


Ala Phe Gln Val Phe Glu Glu Ala Lys Gln Gly His Leu Glu Arg Glu 
    50                  55                  60                  


Cys Val Glu Glu Leu Cys Ser Arg Glu Glu Ala Arg Glu Val Phe Glu 
65                  70                  75                  80  


Asn Asp Pro Glu Thr Asp Tyr Phe Tyr Pro Arg Tyr Leu Asp Cys Ile 
                85                  90                  95      


Asn Lys Tyr Gly Ser Pro Tyr Thr Lys Asn Ser Gly Phe Ala Thr Cys 
            100                 105                 110         


Val Gln Asn Leu Pro Asp Gln Cys Thr Pro Asn Pro Cys Asp Arg Lys 
        115                 120                 125             


Gly Thr Gln Ala Cys Gln Asp Leu Met Gly Asn Phe Phe Cys Leu Cys 
    130                 135                 140                 


Lys Ala Gly Trp Gly Gly Arg Leu Cys Asp Lys Asp Val Asn Glu Cys 
145                 150                 155                 160 


Ser Gln Glu Asn Gly Gly Cys Leu Gln Ile Cys His Asn Lys Pro Gly 
                165                 170                 175     


Ser Phe His Cys Ser Cys His Ser Gly Phe Glu Leu Ser Ser Asp Gly 
            180                 185                 190         


Arg Thr Cys Gln Asp Ile Asp Glu Cys Ala Asp Ser Glu Ala Cys Gly 
        195                 200                 205             


Glu Ala Arg Cys Lys Asn Leu Pro Gly Ser Tyr Ser Cys Leu Cys Asp 
    210                 215                 220                 


Glu Gly Phe Ala Tyr Ser Ser Gln Glu Lys Ala Cys Arg Asp Val Asp 
225                 230                 235                 240 


Glu Cys Leu Gln Gly Arg Cys Glu Gln Val Cys Val Asn Ser Pro Gly 
                245                 250                 255     


Ser Tyr Thr Cys His Cys Asp Gly Arg Gly Gly Leu Lys Leu Ser Gln 
            260                 265                 270         


Asp Met Asp Thr Cys Glu Asp Ile Leu Pro Cys Val Pro Phe Ser Val 
        275                 280                 285             


Ala Lys Ser Val Lys Ser Leu Tyr Leu Gly Arg Met Phe Ser Gly Thr 
    290                 295                 300                 


Pro Val Ile Arg Leu Arg Phe Lys Arg Leu Gln Pro Thr Arg Leu Val 
305                 310                 315                 320 


Ala Glu Phe Asp Phe Arg Thr Phe Asp Pro Glu Gly Ile Leu Leu Phe 
                325                 330                 335     


Ala Gly Gly His Gln Asp Ser Thr Trp Ile Val Leu Ala Leu Arg Ala 
            340                 345                 350         


Gly Arg Leu Glu Leu Gln Leu Arg Tyr Asn Gly Val Gly Arg Val Thr 
        355                 360                 365             


Ser Ser Gly Pro Val Ile Asn His Gly Met Trp Gln Thr Ile Ser Val 
    370                 375                 380                 


Glu Glu Leu Ala Arg Asn Leu Val Ile Lys Val Asn Arg Asp Ala Val 
385                 390                 395                 400 


Met Lys Ile Ala Val Ala Gly Asp Leu Phe Gln Pro Glu Arg Gly Leu 
                405                 410                 415     


Tyr His Leu Asn Leu Thr Val Gly Gly Ile Pro Phe His Glu Lys Asp 
            420                 425                 430         


Leu Val Gln Pro Ile Asn Pro Arg Leu Asp Gly Cys Met Arg Ser Trp 
        435                 440                 445             


Asn Trp Leu Asn Gly Glu Asp Thr Thr Ile Gln Glu Thr Val Lys Val 
    450                 455                 460                 


Asn Thr Arg Met Gln Cys Phe Ser Val Thr Glu Arg Gly Ser Phe Tyr 
465                 470                 475                 480 


Pro Gly Ser Gly Phe Ala Phe Tyr Ser Leu Asp Tyr Met Arg Thr Pro 
                485                 490                 495     


Leu Asp Val Gly Thr Glu Ser Thr Trp Glu Val Glu Val Val Ala His 
            500                 505                 510         


Ile Arg Pro Ala Ala Asp Thr Gly Val Leu Phe Ala Leu Trp Ala Pro 
        515                 520                 525             


Asp Leu Arg Ala Val Pro Leu Ser Val Ala Leu Val Asp Tyr His Ser 
    530                 535                 540                 


Thr Lys Lys Leu Lys Lys Gln Leu Val Val Leu Ala Val Glu His Thr 
545                 550                 555                 560 


Ala Leu Ala Leu Met Glu Ile Lys Val Cys Asp Gly Gln Glu His Val 
                565                 570                 575     


Val Thr Val Ser Leu Arg Asp Gly Glu Ala Thr Leu Glu Val Asp Gly 
            580                 585                 590         


Thr Arg Gly Gln Ser Glu Val Ser Ala Ala Gln Leu Gln Glu Arg Leu 
        595                 600                 605             


Ala Val Leu Glu Arg His Leu Arg Ser Pro Val Leu Thr Phe Ala Gly 
    610                 615                 620                 


Gly Leu Pro Asp Val Pro Val Thr Ser Ala Pro Val Thr Ala Phe Tyr 
625                 630                 635                 640 


Arg Gly Cys Met Thr Leu Glu Val Asn Arg Arg Leu Leu Asp Leu Asp 
                645                 650                 655     


Glu Ala Ala Tyr Lys His Ser Asp Ile Thr Ala His Ser Cys Pro Pro 
            660                 665                 670         


Val Glu Pro Ala Ala Ala 
        675             


<210>  27
<211>  405
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Asp Thr Cys Glu Asp Ile Leu Pro Cys Val Pro Phe Ser Val Ala 
1               5                   10                  15      


Lys Ser Val Lys Ser Leu Tyr Leu Gly Arg Met Phe Ser Gly Thr Pro 
            20                  25                  30          


Val Ile Arg Leu Arg Phe Lys Arg Leu Gln Pro Thr Arg Leu Val Ala 
        35                  40                  45              


Glu Phe Asp Phe Arg Thr Phe Asp Pro Glu Gly Ile Leu Leu Phe Ala 
    50                  55                  60                  


Gly Gly His Gln Asp Ser Thr Trp Ile Val Leu Ala Leu Arg Ala Gly 
65                  70                  75                  80  


Arg Leu Glu Leu Gln Leu Arg Tyr Asn Gly Val Gly Arg Val Thr Ser 
                85                  90                  95      


Ser Gly Pro Val Ile Asn His Gly Met Trp Gln Thr Ile Ser Val Glu 
            100                 105                 110         


Glu Leu Ala Arg Asn Leu Val Ile Lys Val Asn Arg Asp Ala Val Met 
        115                 120                 125             


Lys Ile Ala Val Ala Gly Asp Leu Phe Gln Pro Glu Arg Gly Leu Tyr 
    130                 135                 140                 


His Leu Asn Leu Thr Val Gly Gly Ile Pro Phe His Glu Lys Asp Leu 
145                 150                 155                 160 


Val Gln Pro Ile Asn Pro Arg Leu Asp Gly Cys Met Arg Ser Trp Asn 
                165                 170                 175     


Trp Leu Asn Gly Glu Asp Thr Thr Ile Gln Glu Thr Val Lys Val Asn 
            180                 185                 190         


Thr Arg Met Gln Cys Phe Ser Val Thr Glu Arg Gly Ser Phe Tyr Pro 
        195                 200                 205             


Gly Ser Gly Phe Ala Phe Tyr Ser Leu Asp Tyr Met Arg Thr Pro Leu 
    210                 215                 220                 


Asp Val Gly Thr Glu Ser Thr Trp Glu Val Glu Val Val Ala His Ile 
225                 230                 235                 240 


Arg Pro Ala Ala Asp Thr Gly Val Leu Phe Ala Leu Trp Ala Pro Asp 
                245                 250                 255     


Leu Arg Ala Val Pro Leu Ser Val Ala Leu Val Asp Tyr His Ser Thr 
            260                 265                 270         


Lys Lys Leu Lys Lys Gln Leu Val Val Leu Ala Val Glu His Thr Ala 
        275                 280                 285             


Leu Ala Leu Met Glu Ile Lys Val Cys Asp Gly Gln Glu His Val Val 
    290                 295                 300                 


Thr Val Ser Leu Arg Asp Gly Glu Ala Thr Leu Glu Val Asp Gly Thr 
305                 310                 315                 320 


Arg Gly Gln Ser Glu Val Ser Ala Ala Gln Leu Gln Glu Arg Leu Ala 
                325                 330                 335     


Val Leu Glu Arg His Leu Arg Ser Pro Val Leu Thr Phe Ala Gly Gly 
            340                 345                 350         


Leu Pro Asp Val Pro Val Thr Ser Ala Pro Val Thr Ala Phe Tyr Arg 
        355                 360                 365             


Gly Cys Met Thr Leu Glu Val Asn Arg Arg Leu Leu Asp Leu Asp Glu 
    370                 375                 380                 


Ala Ala Tyr Lys His Ser Asp Ile Thr Ala His Ser Cys Pro Pro Val 
385                 390                 395                 400 


Glu Pro Ala Ala Ala 
                405 


<210>  28
<211>  379
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Phe Ser Gly Thr Pro Val Ile Arg Leu Arg Phe Lys Arg Leu Gln 
1               5                   10                  15      


Pro Thr Arg Leu Val Ala Glu Phe Asp Phe Arg Thr Phe Asp Pro Glu 
            20                  25                  30          


Gly Ile Leu Leu Phe Ala Gly Gly His Gln Asp Ser Thr Trp Ile Val 
        35                  40                  45              


Leu Ala Leu Arg Ala Gly Arg Leu Glu Leu Gln Leu Arg Tyr Asn Gly 
    50                  55                  60                  


Val Gly Arg Val Thr Ser Ser Gly Pro Val Ile Asn His Gly Met Trp 
65                  70                  75                  80  


Gln Thr Ile Ser Val Glu Glu Leu Ala Arg Asn Leu Val Ile Lys Val 
                85                  90                  95      


Asn Arg Asp Ala Val Met Lys Ile Ala Val Ala Gly Asp Leu Phe Gln 
            100                 105                 110         


Pro Glu Arg Gly Leu Tyr His Leu Asn Leu Thr Val Gly Gly Ile Pro 
        115                 120                 125             


Phe His Glu Lys Asp Leu Val Gln Pro Ile Asn Pro Arg Leu Asp Gly 
    130                 135                 140                 


Cys Met Arg Ser Trp Asn Trp Leu Asn Gly Glu Asp Thr Thr Ile Gln 
145                 150                 155                 160 


Glu Thr Val Lys Val Asn Thr Arg Met Gln Cys Phe Ser Val Thr Glu 
                165                 170                 175     


Arg Gly Ser Phe Tyr Pro Gly Ser Gly Phe Ala Phe Tyr Ser Leu Asp 
            180                 185                 190         


Tyr Met Arg Thr Pro Leu Asp Val Gly Thr Glu Ser Thr Trp Glu Val 
        195                 200                 205             


Glu Val Val Ala His Ile Arg Pro Ala Ala Asp Thr Gly Val Leu Phe 
    210                 215                 220                 


Ala Leu Trp Ala Pro Asp Leu Arg Ala Val Pro Leu Ser Val Ala Leu 
225                 230                 235                 240 


Val Asp Tyr His Ser Thr Lys Lys Leu Lys Lys Gln Leu Val Val Leu 
                245                 250                 255     


Ala Val Glu His Thr Ala Leu Ala Leu Met Glu Ile Lys Val Cys Asp 
            260                 265                 270         


Gly Gln Glu His Val Val Thr Val Ser Leu Arg Asp Gly Glu Ala Thr 
        275                 280                 285             


Leu Glu Val Asp Gly Thr Arg Gly Gln Ser Glu Val Ser Ala Ala Gln 
    290                 295                 300                 


Leu Gln Glu Arg Leu Ala Val Leu Glu Arg His Leu Arg Ser Pro Val 
305                 310                 315                 320 


Leu Thr Phe Ala Gly Gly Leu Pro Asp Val Pro Val Thr Ser Ala Pro 
                325                 330                 335     


Val Thr Ala Phe Tyr Arg Gly Cys Met Thr Leu Glu Val Asn Arg Arg 
            340                 345                 350         


Leu Leu Asp Leu Asp Glu Ala Ala Tyr Lys His Ser Asp Ile Thr Ala 
        355                 360                 365             


His Ser Cys Pro Pro Val Glu Pro Ala Ala Ala 
    370                 375                 


<210>  29
<211>  2521
<212>  DNA
<213>  Homo sapiens

<400>  29
ccgagcgctt gaggtgccgc agccgccgcc gccgccgccg ccgcgatgtg accttcaggg       60

ccgccaggac gggatgaccg gagcctccgc cccgcggcgc ccgcggctcg cctcggcctc      120

ccgggcgctc tgaccgcgcg tccccggccc gccatggccc cttcgctctc gcccgggccc      180

gccgccctgc gccgcgcgcc gcagctgctg ctgctgctgc tggccgcgga gtgcgcgctt      240

gccgcgctgt tgccggcgcg cgaggccacg cagttcctgc ggcccaggca gcgccgcgcc      300

tttcaggtct tcgaggaggc caagcagggc cacctggaga gggagtgcgt ggaggagctg      360

tgcagccgcg aggaggcgcg ggaggtgttc gagaacgacc ccgagacgga ttatttttac      420

ccaagatact tagactgcat caacaagtat gggtctccgt acaccaaaaa ctcaggcttc      480

gccacctgcg tgcaaaacct gcctgaccag tgcacgccca acccctgcga taggaagggg      540

acccaagcct gccaggacct catgggcaac ttcttctgcc tgtgtaaagc tggctggggg      600

ggccggctct gcgacaaaga tgtcaacgaa tgcagccagg agaacggggg ctgcctccag      660

atctgccaca acaagccggg tagcttccac tgttcctgcc acagcggctt cgagctctcc      720

tctgatggca ggacctgcca agacatagac gagtgcgcag actcggaggc ctgcggggag      780

gcgcgctgca agaacctgcc cggctcctac tcctgcctct gtgacgaggg ctttgcgtac      840

agctcccagg agaaggcttg ccgagatgtg gacgagtgtc tgcagggccg ctgtgagcag      900

gtctgcgtga actccccagg gagctacacc tgccactgtg acgggcgtgg gggcctcaag      960

ctgtcccagg acatggacac ctgtgaggac atcttgccgt gcgtgccctt cagcgtggcc     1020

aagagtgtga agtccttgta cctgggccgg atgttcagtg ggacccccgt gatccgactg     1080

cgcttcaaga ggctgcagcc caccaggctg gtagctgagt ttgacttccg gacctttgac     1140

cccgagggca tcctcctctt tgccggaggc caccaggaca gcacctggat cgtgctggcc     1200

ctgagagccg gccggctgga gctgcagctg cgctacaacg gtgtcggccg tgtcaccagc     1260

agcggcccgg tcatcaacca tggcatgtgg cagacaatct ctgttgagga gctggcgcgg     1320

aatctggtca tcaaggtcaa cagggatgct gtcatgaaaa tcgcggtggc cggggacttg     1380

ttccaaccgg agcgaggact gtatcatctg aacctgaccg tgggaggtat tcccttccat     1440

gagaaggacc tcgtgcagcc tataaaccct cgtctggatg gctgcatgag gagctggaac     1500

tggctgaacg gagaagacac caccatccag gaaacggtga aagtgaacac gaggatgcag     1560

tgcttctcgg tgacggagag aggctctttc taccccggga gcggcttcgc cttctacagc     1620

ctggactaca tgcggacccc tctggacgtc gggactgaat caacctggga agtagaagtc     1680

gtggctcaca tccgcccagc cgcagacaca ggcgtgctgt ttgcgctctg ggcccccgac     1740

ctccgtgccg tgcctctctc tgtggcactg gtagactatc actccacgaa gaaactcaag     1800

aagcagctgg tggtcctggc cgtggagcat acggccttgg ccctaatgga gatcaaggtc     1860

tgcgacggcc aagagcacgt ggtcaccgtc tcgctgaggg acggtgaggc caccctggag     1920

gtggacggca ccaggggcca gagcgaggtg agcgccgcgc agctgcagga gaggctggcc     1980

gtgctcgaga ggcacctgcg gagccccgtg ctcacctttg ctggcggcct gccagatgtg     2040

ccggtgactt cagcgccagt caccgcgttc taccgcggct gcatgacact ggaggtcaac     2100

cggaggctgc tggacctgga cgaggcggcg tacaagcaca gcgacatcac ggcccactcc     2160

tgcccccccg tggagcccgc cgcagcctag gcccccacgg gacgcggcag gcttctcagt     2220

ctctgtccga gacagccggg aggagcctgg gggctcctca ccacgtgggg ccatgctgag     2280

agctgggctt tcctctgtga ccatcccggc ctgtaacata tctgtaaata gtgagatgga     2340

cttggggcct ctgacgccgc gcactcagcc gtgggcccgg gcgcggggag gccggcgcag     2400

cgcagagcgg gctcgaagaa aataattctc tattattttt attaccaagc gcttctttct     2460

gactctaaaa tatggaaaat aaaatattta cagaaagctt tgtaaaaaaa aaaaaaaaaa     2520

a                                                                     2521


<210>  30
<211>  2188
<212>  DNA
<213>  Homo sapiens

<400>  30
ttgattgaaa ccagtaaatg cttctctttg gggttggggt tttagtttca aatgcccccg       60

gggggttact ttttacggcc ccgtgtcctg tagcaccgtc atttaaatgg aacagcacag      120

cgtgcaccgc cgccccccac ccctccacca agcagggccc ttcccagctc tccacctgct      180

gggctgaagt cagccttccc agccgggcct tgatcagaag cgtgcaccaa caccccggga      240

gctgcccggt caggggagga gggcagggaa atggggccag ggcgcgctgg ccccacagag      300

tctggatgcg acctctgggt ggtgccctgg ccagtccctg cagccgcctg ccccagcccc      360

gtctgagatg ccgctgtgct gcggttggcc ggtttttttt tgcttgcaga catagacgag      420

tgcgcagact cggaggcctg cggggaggcg cgctgcaaga acctgcccgg ctcctactcc      480

tgcctctgtg acgagggctt tgcgtacagc tcccaggaga aggcttgccg agatgtggac      540

gagtgtctgc agggccgctg tgagcaggtc tgcgtgaact ccccagggag ctacacctgc      600

cactgtgacg ggcgtggggg cctcaagctg tcccaggaca tggacacctg tgaggacatc      660

ttgccgtgcg tgcccttcag cgtggccaag agtgtgaagt ccttgtacct gggccggatg      720

ttcagtggga cccccgtgat ccgactgcgc ttcaagaggc tgcagcccac caggctggta      780

gctgagtttg acttccggac ctttgacccc gagggcatcc tcctctttgc cggaggccac      840

caggacagca cctggatcgt gctggccctg agagccggcc ggctggagct gcagctgcgc      900

tacaacggtg tcggccgtgt caccagcagc ggcccggtca tcaaccatgg catgtggcag      960

acaatctctg ttgaggagct ggcgcggaat ctggtcatca aggtcaacag ggatgctgtc     1020

atgaaaatcg cggtggccgg ggacttgttc caaccggagc gaggactgta tcatctgaac     1080

ctgaccgtgg gaggtattcc cttccatgag aaggacctcg tgcagcctat aaaccctcgt     1140

ctggatggct gcatgaggag ctggaactgg ctgaacggag aagacaccac catccaggaa     1200

acggtgaaag tgaacacgag gatgcagtgc ttctcggtga cggagagagg ctctttctac     1260

cccgggagcg gcttcgcctt ctacagcctg gactacatgc ggacccctct ggacgtcggg     1320

actgaatcaa cctgggaagt agaagtcgtg gctcacatcc gcccagccgc agacacaggc     1380

gtgctgtttg cgctctgggc ccccgacctc cgtgccgtgc ctctctctgt ggcactggta     1440

gactatcact ccacgaagaa actcaagaag cagctggtgg tcctggccgt ggagcatacg     1500

gccttggccc taatggagat caaggtctgc gacggccaag agcacgtggt caccgtctcg     1560

ctgagggacg gtgaggccac cctggaggtg gacggcacca ggggccagag cgaggtgagc     1620

gccgcgcagc tgcaggagag gctggccgtg ctcgagaggc acctgcggag ccccgtgctc     1680

acctttgctg gcggcctgcc agatgtgccg gtgacttcag cgccagtcac cgcgttctac     1740

cgcggctgca tgacactgga ggtcaaccgg aggctgctgg acctggacga ggcggcgtac     1800

aagcacagcg acatcacggc ccactcctgc ccccccgtgg agcccgccgc agcctaggcc     1860

cccacgggac gcggcaggct tctcagtctc tgtccgagac agccgggagg agcctggggg     1920

ctcctcacca cgtggggcca tgctgagagc tgggctttcc tctgtgacca tcccggcctg     1980

taacatatct gtaaatagtg agatggactt ggggcctctg acgccgcgca ctcagccgtg     2040

ggcccgggcg cggggaggcc ggcgcagcgc agagcgggct cgaagaaaat aattctctat     2100

tatttttatt accaagcgct tctttctgac tctaaaatat ggaaaataaa atatttacag     2160

aaagctttgt aaaaaaaaaa aaaaaaaa                                        2188


<210>  31
<211>  2523
<212>  DNA
<213>  Homo sapiens

<400>  31
cacaccgacc tgtcacaccg gtgcctgtca caccactgcc tgtcacactg acttgtcacc       60

ggtgtctgtc acaccgacct gtcacactgg tgcctgtcac actggtgcct gtcacaccga      120

cctgtcacac cggtgcctgt cacaccgacc tgtcacactg acctgtcaca ccggtaggaa      180

tgcagtaccc acatgtggac gtttctgggc agggcggctc ttgtctttcc tcttcagcct      240

gggcctgtgc ctgggggttg atgagagtga gcatttattt aaaaagcaaa accacaggtg      300

gaaagagtca ccaggacagc ttctcggagt cgcagacctg ggatgcagcc gtggggctct      360

tgggtctggg ctgcgacgtt cagggcttcc agccagccct cgccttgagg ttctttgcct      420

cgctgcctca tgtactcatg cagagggtgt cggacccctg cgagatgtcc agctcaccct      480

ggctgcccac ggtgggcagg gcaggcctgg ctcagcccca gcccctccat cttccagggg      540

tgtcagctca caccggcttt ggttctgtcc cccttcgggc agcgtggaga aaccacagcc      600

cagaacaggg aactttccag gacagccatc ttcaaggcat ccatatctat ttcataatag      660

tgtatacttt ttaatgattc tctgtaattt ttgtatgctt gaaatatttc ataatttaaa      720

aataaagggt caagggaaat gagcagggaa ggagatgacg gggacccccg agaagccctg      780

tgggaagcgg ctgctgcaag cccgcccttc acctgggagt cccagtgggg caggtgtgac      840

agcctctggg gtctcagcag ctagaggcgg ggtggccact cccgaggcac aggagggaca      900

gtggacccgc tgcgcggccg gggcgtgggg ctcaggggag caggagtgaa ggccacatcc      960

ccgaccggcg tggcccccgt ccgtggcagg acatcttgcc gtgcgtgccc ttcagcgtgg     1020

ccaagagtgt gaagtccttg tacctgggcc ggatgttcag tgggaccccc gtgatccgac     1080

tgcgcttcaa gaggctgcag cccaccaggc tggtagctga gtttgacttc cggacctttg     1140

accccgaggg catcctcctc tttgccggag gccaccagga cagcacctgg atcgtgctgg     1200

ccctgagagc cggccggctg gagctgcagc tgcgctacaa cggtgtcggc cgtgtcacca     1260

gcagcggccc ggtcatcaac catggcatgt ggcagacaat ctctgttgag gagctggcgc     1320

ggaatctggt catcaaggtc aacagggatg ctgtcatgaa aatcgcggtg gccggggact     1380

tgttccaacc ggagcgagga ctgtatcatc tgaacctgac cgtgggaggt attcccttcc     1440

atgagaagga cctcgtgcag cctataaacc ctcgtctgga tggctgcatg aggagctgga     1500

actggctgaa cggagaagac accaccatcc aggaaacggt gaaagtgaac acgaggatgc     1560

agtgcttctc ggtgacggag agaggctctt tctaccccgg gagcggcttc gccttctaca     1620

gcctggacta catgcggacc cctctggacg tcgggactga atcaacctgg gaagtagaag     1680

tcgtggctca catccgccca gccgcagaca caggcgtgct gtttgcgctc tgggcccccg     1740

acctccgtgc cgtgcctctc tctgtggcac tggtagacta tcactccacg aagaaactca     1800

agaagcagct ggtggtcctg gccgtggagc atacggcctt ggccctaatg gagatcaagg     1860

tctgcgacgg ccaagagcac gtggtcaccg tctcgctgag ggacggtgag gccaccctgg     1920

aggtggacgg caccaggggc cagagcgagg tgagcgccgc gcagctgcag gagaggctgg     1980

ccgtgctcga gaggcacctg cggagccccg tgctcacctt tgctggcggc ctgccagatg     2040

tgccggtgac ttcagcgcca gtcaccgcgt tctaccgcgg ctgcatgaca ctggaggtca     2100

accggaggct gctggacctg gacgaggcgg cgtacaagca cagcgacatc acggcccact     2160

cctgcccccc cgtggagccc gccgcagcct aggcccccac gggacgcggc aggcttctca     2220

gtctctgtcc gagacagccg ggaggagcct gggggctcct caccacgtgg ggccatgctg     2280

agagctgggc tttcctctgt gaccatcccg gcctgtaaca tatctgtaaa tagtgagatg     2340

gacttggggc ctctgacgcc gcgcactcag ccgtgggccc gggcgcgggg aggccggcgc     2400

agcgcagagc gggctcgaag aaaataattc tctattattt ttattaccaa gcgcttcttt     2460

ctgactctaa aatatggaaa ataaaatatt tacagaaagc tttgtaaaaa aaaaaaaaaa     2520

aaa                                                                   2523


<210>  32
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA against AXL receptor

<400>  32
acagcgagau uuaugacua                                                    19


<210>  33
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA against AXL receptor

<400>  33
gguaccggcu ggcguauca                                                    19


<210>  34
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA against AXL receptor

<400>  34
gacgaaaucc ucuauguca                                                    19


<210>  35
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA against AXL receptor

<400>  35
gaaggagacc cguuaugga                                                    19


<210>  36
<211>  559
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant Gas6deltaGla protein

<400>  36

Asp Gln Cys Thr Pro Asn Pro Cys Asp Lys Lys Gly Thr His Ile Cys 
1               5                   10                  15      


Gln Asp Leu Met Gly Asn Phe Phe Cys Val Cys Thr Asp Gly Trp Gly 
            20                  25                  30          


Gly Arg Leu Cys Asp Lys Asp Val Asn Glu Cys Val Gln Lys Asn Gly 
        35                  40                  45              


Gly Cys Ser Gln Val Cys His Asn Lys Pro Gly Ser Phe Gln Cys Ala 
    50                  55                  60                  


Cys His Ser Gly Phe Ser Leu Ala Ser Asp Gly Gln Thr Cys Gln Asp 
65                  70                  75                  80  


Ile Asp Glu Cys Thr Asp Ser Asp Thr Cys Gly Asp Ala Arg Cys Lys 
                85                  90                  95      


Asn Leu Pro Gly Ser Tyr Ser Cys Leu Cys Asp Glu Gly Tyr Thr Tyr 
            100                 105                 110         


Ser Ser Lys Glu Lys Thr Cys Gln Asp Val Asp Glu Cys Gln Gln Asp 
        115                 120                 125             


Arg Cys Glu Gln Thr Cys Val Asn Ser Pro Gly Ser Tyr Thr Cys His 
    130                 135                 140                 


Cys Asp Gly Arg Gly Gly Leu Lys Leu Ser Pro Asp Met Asp Thr Cys 
145                 150                 155                 160 


Glu Asp Ile Leu Pro Cys Val Pro Phe Ser Met Ala Lys Ser Val Lys 
                165                 170                 175     


Ser Leu Tyr Leu Gly Arg Met Phe Ser Gly Thr Pro Val Ile Arg Leu 
            180                 185                 190         


Arg Phe Lys Arg Leu Gln Pro Thr Arg Leu Leu Ala Glu Phe Asp Phe 
        195                 200                 205             


Arg Thr Phe Asp Pro Glu Gly Val Leu Phe Phe Ala Gly Gly Arg Ser 
    210                 215                 220                 


Asp Ser Thr Trp Ile Val Leu Gly Leu Arg Ala Gly Arg Leu Glu Leu 
225                 230                 235                 240 


Gln Leu Arg Tyr Asn Gly Val Gly Arg Ile Thr Ser Ser Gly Pro Thr 
                245                 250                 255     


Ile Asn His Gly Met Trp Gln Thr Ile Ser Val Glu Glu Leu Glu Arg 
            260                 265                 270         


Asn Leu Val Ile Lys Val Asn Lys Asp Ala Val Met Lys Ile Ala Val 
        275                 280                 285             


Ala Gly Glu Leu Phe Gln Leu Glu Arg Gly Leu Tyr His Leu Asn Leu 
    290                 295                 300                 


Thr Val Gly Gly Ile Pro Phe Lys Glu Ser Glu Leu Val Gln Pro Ile 
305                 310                 315                 320 


Asn Pro Arg Leu Asp Gly Cys Met Arg Ser Trp Asn Trp Leu Asn Gly 
                325                 330                 335     


Glu Asp Ser Ala Ile Gln Glu Thr Val Lys Ala Asn Thr Lys Met Gln 
            340                 345                 350         


Cys Phe Ser Val Thr Glu Arg Gly Ser Phe Phe Pro Gly Asn Gly Phe 
        355                 360                 365             


Ala Thr Tyr Arg Leu Asn Tyr Thr Arg Thr Ser Leu Asp Val Gly Thr 
    370                 375                 380                 


Glu Thr Thr Trp Glu Val Lys Val Val Ala Arg Ile Arg Pro Ala Thr 
385                 390                 395                 400 


Asp Thr Gly Val Leu Leu Ala Leu Val Gly Asp Asp Asp Val Val Ile 
                405                 410                 415     


Ser Val Ala Leu Val Asp Tyr His Ser Thr Lys Lys Leu Lys Lys Gln 
            420                 425                 430         


Leu Val Val Leu Ala Val Glu Asp Val Ala Leu Ala Leu Met Glu Ile 
        435                 440                 445             


Lys Val Cys Asp Ser Gln Glu His Thr Val Thr Val Ser Leu Arg Glu 
    450                 455                 460                 


Gly Glu Ala Thr Leu Glu Val Asp Gly Thr Lys Gly Gln Ser Glu Val 
465                 470                 475                 480 


Ser Thr Ala Gln Leu Gln Glu Arg Leu Asp Thr Leu Lys Thr His Leu 
                485                 490                 495     


Gln Gly Ser Val His Thr Tyr Val Gly Gly Leu Pro Glu Val Ser Val 
            500                 505                 510         


Ile Ser Ala Pro Val Thr Ala Phe Tyr Arg Gly Cys Met Thr Leu Glu 
        515                 520                 525             


Val Asn Gly Lys Ile Leu Asp Leu Asp Thr Ala Ser Tyr Lys His Ser 
    530                 535                 540                 


Asp Ile Thr Ser His Ser Cys Pro Pro Val Glu His Ala Thr Pro 
545                 550                 555                 


<210>  37
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  37
cgggatcccg catggcgctg aggcggagca tgg                                    33


<210>  38
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  38
gtccttttgg gggtcccagc ctgtcaaatt ggc                                    33


<210>  39
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  39
gccaatttga caggctggga cccccaaaag gac                                    33


<210>  40
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  40
ccgctcgagc ggctaacagc tactgtgtgg cagtagccc                              39


<210>  41
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  41
cgggatcccg catggcgtgg cggtgcccc                                         29


<210>  42
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  42
ccgctcgagc ggtcaggcac catcctcctg ccc                                    33


<210>  43
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  43
atcggagata tctgtaaagg ttggtggaga ggcaggtcc                              39


<210>  44
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  44
tctggaagat cttcctttag tggtattggc cgtcag                                 36


<210>  45
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  45
atcggagata tcagagactg ttgtgacgga ggttttggg                              39


<210>  46
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  46
tctggaagat ctttgggaga tgggcatttc attcttc                                37

<210>  47
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  47

Met His Pro Gln Val Val Ile Leu Ser Leu Ile Leu His Leu Ala Asp 
1               5                   10                  15      


Ser Val Ala Gly Ser Val Lys Val Gly Gly Glu Ala Gly Pro Ser Val 
            20                  25                  30          


Thr Leu Pro Cys His Tyr Ser Gly Ala Val Thr Ser Met Cys Trp Asn 
        35                  40                  45              


Arg Gly Ser Cys Ser Leu Phe Thr Cys Gln Asn Gly Ile Val Trp Thr 
    50                  55                  60                  


Asn Gly Thr His Val Thr Tyr Arg Lys Asp Thr Arg Tyr Lys Leu Leu 
65                  70                  75                  80  


Gly Asp Leu Ser Arg Arg Asp Val Ser Leu Thr Ile Glu Asn Thr Ala 
                85                  90                  95      


Val Ser Asp Ser Gly Val Tyr Cys Cys Arg Val Glu His Arg Gly Trp 
            100                 105                 110         


Phe Asn Asp Met Lys Ile Thr Val Ser Leu Glu Ile Val Pro Pro Lys 
        115                 120                 125             


Val Thr Thr Thr Pro Ile Val Thr Thr Val Pro Thr Val Thr Thr Val 
    130                 135                 140                 


Arg Thr Ser Thr Thr Val Pro Thr Thr Thr Thr Val Pro Thr Thr Thr 
145                 150                 155                 160 


Val Pro Thr Thr Met Ser Ile Pro Thr Thr Thr Thr Val Leu Thr Thr 
                165                 170                 175     


Met Thr Val Ser Thr Thr Thr Ser Val Pro Thr Thr Thr Ser Ile Pro 
            180                 185                 190         


Thr Thr Thr Ser Val Pro Val Thr Thr Thr Val Ser Thr Phe Val Pro 
        195                 200                 205             


Pro Met Pro Leu Pro Arg Gln Asn His Glu Pro Val Ala Thr Ser Pro 
    210                 215                 220                 


Ser Ser Pro Gln Pro Ala Glu Thr His Pro Thr Thr Leu Gln Gly Ala 
225                 230                 235                 240 


Ile Arg Arg Glu Pro Thr Ser Ser Pro Leu Tyr Ser Tyr Thr Thr Asp 
                245                 250                 255     


Gly Asn Asp Thr Val Thr Glu Ser Ser Asp Gly Leu Trp Asn Asn Asn 
            260                 265                 270         


Gln Thr Gln Leu Phe Leu Glu His Ser Leu Leu Thr Ala Asn Thr Thr 
        275                 280                 285             


Lys Gly Ile Tyr Ala Gly Val Cys Ile Ser Val Leu Val Leu Leu Ala 
    290                 295                 300                 


Leu Leu Gly Val Ile Ile Ala Lys Lys Tyr Phe Phe Lys Lys Glu Val 
305                 310                 315                 320 


Gln Gln Leu Ser Val Ser Phe Ser Ser Leu Gln Ile Lys Ala Leu Gln 
                325                 330                 335     


Asn Ala Val Glu Lys Glu Val Gln Ala Glu Asp Asn Ile Tyr Ile Glu 
            340                 345                 350         


Asn Ser Leu Tyr Ala Thr Asp 
        355                 

