                         SEQUENCE LISTING

<110>  Seattle Genetics, Inc.
 
<120>  ANTIBODIES TO INTEGRIN ALPHA VBETA6 AND USE OF SAME TO TREAT 
       CANCER

<130>  AVB6-00112PC

<150>  US 61/600,499
<151>  2012-02-17

<150>  US 61/602,511
<151>  2012-02-23

<160>  55    

<170>  PatentIn version 3.5

<210>  1
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  murine heavy chain variable region

<400>  1

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ser Gly Tyr 
            20                  25                  30          


Phe Met Asn Trp Val Lys Gln Ser His Gly Gln Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Asp Ser Phe Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Gln Lys Ser Ser Ser Thr Ala His 
65                  70                  75                  80  


Met Glu Leu Gln Ser Leu Thr Ser Glu Asp Ser Ala Val Phe Tyr Cys 
                85                  90                  95      


Val Arg Gly Leu Arg Arg Asp Phe Asp Tyr Trp Gly Gln Gly Thr Pro 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  2
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  murine light chain variable region

<400>  2

Asp Val Val Leu Thr Gln Ile Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Leu Phe Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Phe Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Glu Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  3
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  murine heavy chain CDR1

<400>  3

Gly Tyr Phe Met Asn 
1               5   


<210>  4
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  murine heavy chain CDR2

<400>  4

Leu Ile Asn Pro Tyr Asn Gly Asp Ser Phe Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  5
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  murine heavy chain CDR3

<400>  5

Gly Leu Arg Arg Asp Phe Asp Tyr 
1               5               


<210>  6
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  murine light chain CDR1

<400>  6

Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  7
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  murine light chain CDR2

<400>  7

Leu Val Ser Glu Leu Asp Ser 
1               5           


<210>  8
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  murine light chain CDR3

<400>  8

Trp Gln Gly Thr His Phe Pro Arg Thr 
1               5                   


<210>  9
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  HA heavy chain variable region

<400>  9

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Phe Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Asp Ser Phe Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Arg Arg Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  10
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  LA light chain variable region

<400>  10

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Leu Val Ser Glu Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  11
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  HB heavy chain variable region

<400>  11

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ser Gly Tyr 
            20                  25                  30          


Phe Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Asp Ser Phe Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Arg Arg Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  12
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  HF heavy chain variable region

<400>  12

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Phe Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Asp Ser Phe Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Leu Arg Arg Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  13
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  HG heavy chain variable region

<400>  13

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Phe Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Asp Ser Phe Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Gln Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Arg Arg Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  14
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  HK heavy chain variable region

<400>  14

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Phe Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Asp Ser Phe Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Arg Arg Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  15
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  HL heavy chain variable region

<400>  15

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ser Gly Tyr 
            20                  25                  30          


Phe Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Asp Ser Phe Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Arg Arg Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  16
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  HM heavy chain variable region

<400>  16

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ser Gly Tyr 
            20                  25                  30          


Phe Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Asp Ser Phe Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Gln Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Arg Arg Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  17
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  HN heavy chain variable region

<400>  17

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ser Gly Tyr 
            20                  25                  30          


Phe Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Asp Ser Phe Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Gln Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Arg Arg Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  18
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  HO heavy chain variable region

<400>  18

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ser Gly Tyr 
            20                  25                  30          


Phe Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Asp Ser Phe Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Gln Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Arg Arg Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  19
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  HQ heavy chain variable region

<400>  19

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Phe Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Asp Ser Phe Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Arg Arg Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  20
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  HR heavy chain variable region

<400>  20

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ser Gly Tyr 
            20                  25                  30          


Phe Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Asp Ser Phe Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Arg Arg Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  21
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  HS heavy chain variable region

<400>  21

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ser Gly Tyr 
            20                  25                  30          


Phe Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Asp Ser Phe Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Gln Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Arg Arg Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  22
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  HT heavy chain variable region

<400>  22

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ser Gly Tyr 
            20                  25                  30          


Phe Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Asp Ser Phe Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Gln Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Leu Arg Arg Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  23
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  HU heavy chain variable region

<400>  23

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ser Gly Tyr 
            20                  25                  30          


Phe Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Asp Ser Phe Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Gln Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Leu Arg Arg Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  24
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  LB light chain variable region

<400>  24

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Leu Phe Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Leu Val Ser Glu Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  25
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  LC light chain variable region

<400>  25

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Phe Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Leu Val Ser Glu Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  26
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  LD light chain variable region

<400>  26

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Glu Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  27
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  LE light chain variable region

<400>  27

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Leu Val Ser Glu Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  28
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  LF light chain variable region

<400>  28

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Leu Phe Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Phe Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Glu Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  29
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  LG light chain variable region

<400>  29

Asp Val Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Phe Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Leu Val Ser Glu Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  30
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  human IgG1 heavy chain constant region

<400>  30

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  31
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  human kappa light chain constant domain

<400>  31

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  32
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  human IgG1 heavy chain constant region S239C mutant

<400>  32

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Cys Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  33
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  murine heavy chain variable region signal peptide

<400>  33

Met Gly Trp Ser Cys Ile Phe Leu Phe Leu Leu Ser Val Thr Val Gly 
1               5                   10                  15      


Val Phe Ser 
            


<210>  34
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  human heavy chain variable region signal peptide

<400>  34

Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser 
1               5                   10                  15      


Ala Gln Ala 
            


<210>  35
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  murine light chain variable region signal peptide

<400>  35

Met Ser Pro Ala Gln Phe Leu Phe Leu Leu Val Leu Trp Ile Arg Glu 
1               5                   10                  15      


Thr Asn Gly 
            


<210>  36
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  human light chain variable region signal peptide

<400>  36

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser 
            


<210>  37
<211>  351
<212>  DNA
<213>  Artificial

<220>
<223>  mouse heavy chain variable region

<400>  37
gaggttcagc tgcagcagtc tggacctgag ttggtgaaac ctggggcttc agtgaagata       60

tcctgcaagg cttctggtta ttcatttagt ggctacttta tgaactgggt gaaacagagc      120

catggacaga gccttgagtg gattggactt attaatcctt acaatggaga ctctttttac      180

aatcagaagt tcaagggcaa ggccacattg actgtacaga agtcctctag tacagcccac      240

atggaactcc agagcctgac atctgaagac tctgcagtct tttattgtgt tagagggtta      300

cgacgggact ttgactattg gggccaaggc acccctctca cagtctcctc a               351


<210>  38
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  mouse light chain variable region

<400>  38
gatgttgtgt tgacccagat tccactcact ttgtcggtta ccattggaca accagcctcc       60

ctcttttgta agtcaagtca gagcctctta gatagtgatg gaaagacata tttgaattgg      120

ttatttcaga ggccaggcca gtctccaaag cgccttattt atctggtgtc tgaactggac      180

tctggagtcc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc      240

agcagagtgg aggctgagga tttgggagtt tattattgct ggcaaggtac acattttcct      300

cggacgttcg gtggaggcac caagctggaa atcaaacgg                             339


<210>  39
<211>  351
<212>  DNA
<213>  Artificial

<220>
<223>  HA heavy chain variable region

<400>  39
caggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggagcctc tgtgaaggtg       60

tcctgtaagg cctctggcta caccttcaca ggctacttca tgaactgggt gaggcaggcc      120

cctggccagg gcctggagtg gatgggcctg atcaaccctt acaatggaga ctccttctac      180

aaccagaagt tcaagggcag ggtgaccatg accagggaca cctccacctc cacagtgtac      240

atggagctgt cctccctgag gtctgaggac acagctgtgt actactgtgc caggggcctg      300

aggagggact ttgactactg gggccagggc accctggtga cagtgtcctc c               351


<210>  40
<211>  351
<212>  DNA
<213>  Artificial

<220>
<223>  HB heavy chain variable region

<400>  40
caggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggagcctc tgtgaaggtg       60

tcctgtaagg cctctggcta cagcttctct ggctacttca tgaactgggt gaggcaggcc      120

cctggccagg gcctggagtg gatgggcctg atcaaccctt acaatggaga ctccttctac      180

aaccagaagt tcaagggcag ggtgaccatg accagggaca cctccacctc cacagtgtac      240

atggagctgt cctccctgag gtctgaggac acagctgtgt actactgtgc caggggcctg      300

aggagggact ttgactactg gggccagggc accctggtga cagtgtcctc c               351


<210>  41
<211>  351
<212>  DNA
<213>  Artificial

<220>
<223>  HL heavy chain variable region

<400>  41
caggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggagcctc tgtgaaggtg       60

tcctgtaagg cctctggcta cagcttctct ggctacttca tgaactgggt gaggcaggcc      120

cctggccagg gcctggagtg gatgggcctg atcaaccctt acaatggaga ctccttctac      180

aaccagaagt tcaagggcag ggtgaccatg accagggaca agtcctcctc cacagcttac      240

atggagctgt cctccctgag gtctgaggac acagctgtgt actactgtgc caggggcctg      300

aggagggact ttgactactg gggccagggc accctggtga cagtgtcctc c               351


<210>  42
<211>  351
<212>  DNA
<213>  Artificial

<220>
<223>  HT heavy chain variable region

<400>  42
caggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggagcctc tgtgaaggtg       60

tcctgtaagg cctctggcta cagcttctct ggctacttca tgaactgggt gaggcaggcc      120

cctggccagg gcctggagtg gatgggcctg atcaaccctt acaatggaga ctccttctac      180

aaccagaagt tcaagggcag ggtgaccatg accaggcaga cctccacctc cacagtgtac      240

atggagctgt cctccctgag gtctgaggac acagctgtgt actactgtgt caggggcctg      300

aggagggact ttgactactg gggccagggc accctggtga cagtgtcctc c               351


<210>  43
<211>  351
<212>  DNA
<213>  Artificial

<220>
<223>  HN heavy chain variable region

<400>  43
caggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggagcctc tgtgaaggtg       60

tcctgtaagg cctctggcta cagcttctct ggctacttca tgaactgggt gaggcaggcc      120

cctggccagg gcctggagtg gatgggcctg atcaaccctt acaatggaga ctccttctac      180

aaccagaagt tcaagggcag ggtgaccatg accaggcaga cctccacctc cacagtgtac      240

atggagctgt cctccctgag gtctgaggac acagctgtgt actactgtgc caggggcctg      300

aggagggact ttgactactg gggccagggc accctggtga cagtgtcctc c               351


<210>  44
<211>  351
<212>  DNA
<213>  Artificial

<220>
<223>  HU heavy chain variable region

<400>  44
caggtgcagc tggtgcagtc tggagctgag gtgaagaagc ctggagcctc tgtgaaggtg       60

tcctgtaagg cctctggcta cagcttctct ggctacttca tgaactgggt gaggcaggcc      120

cctggccagg gcctggagtg gatgggcctg atcaaccctt acaatggaga ctccttctac      180

aaccagaagt tcaagggcag ggtgaccatg accaggcaga agtcctcctc cacagcttac      240

atggagctgt cctccctgag gtctgaggac acagctgtgt actactgtgt caggggcctg      300

aggagggact ttgactactg gggccagggc accctggtga cagtgtcctc c               351


<210>  45
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  LA light chain variable region

<400>  45
gatgtggtga tgacccagtc ccctctgtcc ctgcctgtga ccctgggcca gcctgcctcc       60

atctcctgta agtcctccca gtccctgctg gactctgatg gcaagaccta cctgaactgg      120

ttccagcaga ggcctggcca gtcccctagg aggctgatct acctggtgtc tgagctggac      180

tctggagtgc ctgacaggtt ctctggctct ggctctggca cagacttcac cctgaagatc      240

tccagggtgg aggctgagga tgtgggagtg tactactgtt ggcagggcac ccacttccct      300

aggacctttg gaggtggaac caagctggag atcaagcgt                             339


<210>  46
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  LC light chain variable region

<400>  46
gatgtggtga tgacccagtc ccctctgtcc ctgcctgtga ccctgggcca gcctgcctcc       60

atctcctgta agtcctccca gtccctgctg gactctgatg gcaagaccta cctgaactgg      120

ctgttccaga ggcctggcca gtcccctagg aggctgatct acctggtgtc tgagctggac      180

tctggagtgc ctgacaggtt ctctggctct ggctctggca cagacttcac cctgaagatc      240

tccagggtgg aggctgagga tgtgggagtg tactactgtt ggcagggcac ccacttccct      300

aggacctttg gaggtggaac caagctggag atcaagcgt                             339


<210>  47
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  LF light chain variable region

<400>  47
gatgtggtga tgacccagtc ccctctgtcc ctgcctgtga ccctgggcca gcctgcctcc       60

ctgttctgta agtcctccca gtccctgctg gactctgatg gcaagaccta cctgaactgg      120

ctgttccaga ggcctggcca gtcccctaag aggctgatct acctggtgtc tgagctggac      180

tctggagtgc ctgacaggtt cacaggctct ggctctggca cagacttcac cctgaagatc      240

tccagggtgg aggctgagga tgtgggagtg tactactgtt ggcagggcac ccacttccct      300

aggacctttg gaggtggaac caagctggag atcaagcgt                             339


<210>  48
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  LG light chain variable region

<400>  48
gatgtggtgc tgacccagtc ccctctgtcc ctgcctgtga ccctgggcca gcctgcctcc       60

atctcctgta agtcctccca gtccctgctg gactctgatg gcaagaccta cctgaactgg      120

ctgttccaga ggcctggcca gtcccctagg aggctgatct acctggtgtc tgagctggac      180

tctggagtgc ctgacaggtt ctctggctct ggctctggca cagacttcac cctgaagatc      240

tccagggtgg aggctgagga tgtgggagtg tactactgtt ggcagggcac ccacttccct      300

aggacctttg gaggtggaac caagctggag atcaagcgt                             339


<210>  49
<211>  57
<212>  DNA
<213>  Artificial

<220>
<223>  murine heavy chain variable region signal peptide

<400>  49
atgggatgga gctgtatctt tctctttctc ctgtcagtaa ctgtaggtgt gttctct          57


<210>  50
<211>  57
<212>  DNA
<213>  Artificial

<220>
<223>  human heavy chain variable region signal peptide

<400>  50
atggcttggg tgtggacctt gctattcctg atggcagctg cccaaagtgc ccaagca          57


<210>  51
<211>  57
<212>  DNA
<213>  Artificial

<220>
<223>  murine light chain variable region signal peptide

<400>  51
atgagtcctg cccagttcct gtttctgtta gtgctctgga ttcgggaaac caacggt          57


<210>  52
<211>  57
<212>  DNA
<213>  Artificial

<220>
<223>  human light chain variable region signal peptide

<400>  52
atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctgcttc cagcagt          57


<210>  53
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  human IgG1 heavy chain constant region

<400>  53
gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag      720

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  54
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  human kappa light chain constant domain

<400>  54
actgtggcgg cgccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgt                                                    318


<210>  55
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  human IgG1 heavy chain constant region S239C mutant

<400>  55
gctagcacca agggcccatc tgtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagctg ccctgggctg cctggtcaag gactacttcc ctgaacctgt gacagtgtcc      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtgtgtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag      720

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacaca      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


