                               SEQUENCE LISTING

<110> SANTARUS, INC.
 
<120> ANTIBODY FORMULATIONS

<130> C2095-7004WO

<140>
<141>

<150> 61/599,827
<151> 2012-02-16

<160> 6     

<170> PatentIn version 3.5

<210> 1
<211> 213
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1
Gln Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Asn His Met 
            20                  25                  30          


Phe Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Gly Asn Pro Trp Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210> 2
<211> 447
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 2
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly His Thr Tyr Tyr Leu Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Gly Phe Gly Asp Gly Gly Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445         


<210> 3
<211> 1179
<212> PRT
<213> Homo sapiens

<400> 3
Met Ala Pro Arg Pro Arg Ala Arg Pro Gly Val Ala Val Ala Cys Cys 
1               5                   10                  15      


Trp Leu Leu Thr Val Val Leu Arg Cys Cys Val Ser Phe Asn Val Asp 
            20                  25                  30          


Val Lys Asn Ser Met Thr Phe Ser Gly Pro Val Glu Asp Met Phe Gly 
        35                  40                  45              


Tyr Thr Val Gln Gln Tyr Glu Asn Glu Glu Gly Lys Trp Val Leu Ile 
    50                  55                  60                  


Gly Ser Pro Leu Val Gly Gln Pro Lys Asn Arg Thr Gly Asp Val Tyr 
65                  70                  75                  80  


Lys Cys Pro Val Gly Arg Gly Glu Ser Leu Pro Cys Val Lys Leu Asp 
                85                  90                  95      


Leu Pro Val Asn Thr Ser Ile Pro Asn Val Thr Glu Val Lys Glu Asn 
            100                 105                 110         


Met Thr Phe Gly Ser Thr Leu Val Thr Asn Pro Asn Gly Gly Phe Leu 
        115                 120                 125             


Ala Cys Gly Pro Leu Tyr Ala Tyr Arg Cys Gly His Leu His Tyr Thr 
    130                 135                 140                 


Thr Gly Ile Cys Ser Asp Val Ser Pro Thr Phe Gln Val Val Asn Ser 
145                 150                 155                 160 


Ile Ala Pro Val Gln Glu Cys Ser Thr Gln Leu Asp Ile Val Ile Val 
                165                 170                 175     


Leu Asp Gly Ser Asn Ser Ile Tyr Pro Trp Asp Ser Val Thr Ala Phe 
            180                 185                 190         


Leu Asn Asp Leu Leu Glu Arg Met Asp Ile Gly Pro Lys Gln Thr Gln 
        195                 200                 205             


Val Gly Ile Val Gln Tyr Gly Glu Asn Val Thr His Glu Phe Asn Leu 
    210                 215                 220                 


Asn Lys Tyr Ser Ser Thr Glu Glu Val Leu Val Ala Ala Lys Lys Ile 
225                 230                 235                 240 


Val Gln Arg Gly Gly Arg Gln Thr Met Thr Ala Leu Gly Ile Asp Thr 
                245                 250                 255     


Ala Arg Lys Glu Ala Phe Thr Glu Ala Arg Gly Ala Arg Arg Gly Val 
            260                 265                 270         


Lys Lys Val Met Val Ile Val Thr Asp Gly Glu Ser His Asp Asn His 
        275                 280                 285             


Arg Leu Lys Lys Val Ile Gln Asp Cys Glu Asp Glu Asn Ile Gln Arg 
    290                 295                 300                 


Phe Ser Ile Ala Ile Leu Gly Ser Tyr Asn Arg Gly Asn Leu Ser Thr 
305                 310                 315                 320 


Glu Lys Phe Val Glu Glu Ile Lys Ser Ile Ala Ser Glu Pro Thr Glu 
                325                 330                 335     


Lys His Phe Phe Asn Val Ser Asp Glu Leu Ala Leu Val Thr Ile Val 
            340                 345                 350         


Lys Thr Leu Gly Glu Arg Ile Phe Ala Leu Glu Ala Thr Ala Asp Gln 
        355                 360                 365             


Ser Ala Ala Ser Phe Glu Met Glu Met Ser Gln Thr Gly Phe Ser Ala 
    370                 375                 380                 


His Tyr Ser Gln Asp Trp Val Met Leu Gly Ala Val Gly Ala Tyr Asp 
385                 390                 395                 400 


Trp Asn Gly Thr Val Val Met Gln Lys Ala Ser Gln Ile Ile Ile Pro 
                405                 410                 415     


Arg Asn Thr Thr Phe Asn Val Glu Ser Thr Lys Lys Asn Glu Pro Leu 
            420                 425                 430         


Ala Ser Tyr Leu Gly Tyr Thr Val Asn Ser Ala Thr Ala Ser Ser Gly 
        435                 440                 445             


Asp Val Leu Tyr Ile Ala Gly Gln Pro Arg Tyr Asn His Thr Gly Gln 
    450                 455                 460                 


Val Ile Ile Tyr Arg Met Glu Asp Gly Asn Ile Lys Ile Leu Gln Thr 
465                 470                 475                 480 


Leu Ser Gly Glu Gln Ile Gly Ser Tyr Phe Gly Ser Ile Leu Thr Thr 
                485                 490                 495     


Thr Asp Ile Asp Lys Asp Ser Asn Thr Asp Ile Leu Leu Val Gly Ala 
            500                 505                 510         


Pro Met Tyr Met Gly Thr Glu Lys Glu Glu Gln Gly Lys Val Tyr Val 
        515                 520                 525             


Tyr Ala Leu Asn Gln Thr Arg Phe Glu Tyr Gln Met Ser Leu Glu Pro 
    530                 535                 540                 


Ile Lys Gln Thr Cys Cys Ser Ser Arg Gln His Asn Ser Cys Thr Thr 
545                 550                 555                 560 


Glu Asn Lys Asn Glu Pro Cys Gly Ala Arg Phe Gly Thr Ala Ile Ala 
                565                 570                 575     


Ala Val Lys Asp Leu Asn Leu Asp Gly Phe Asn Asp Ile Val Ile Gly 
            580                 585                 590         


Ala Pro Leu Glu Asp Asp His Gly Gly Ala Val Tyr Ile Tyr His Gly 
        595                 600                 605             


Ser Gly Lys Thr Ile Arg Lys Glu Tyr Ala Gln Arg Ile Pro Ser Gly 
    610                 615                 620                 


Gly Asp Gly Lys Thr Leu Lys Phe Phe Gly Gln Ser Ile His Gly Glu 
625                 630                 635                 640 


Met Asp Leu Asn Gly Asp Gly Leu Thr Asp Val Thr Ile Gly Gly Leu 
                645                 650                 655     


Gly Gly Ala Ala Leu Phe Trp Ser Arg Asp Val Ala Val Val Lys Val 
            660                 665                 670         


Thr Met Asn Phe Glu Pro Asn Lys Val Asn Ile Gln Lys Lys Asn Cys 
        675                 680                 685             


His Met Glu Gly Lys Glu Thr Val Cys Ile Asn Ala Thr Val Cys Phe 
    690                 695                 700                 


Asp Val Lys Leu Lys Ser Lys Glu Asp Thr Ile Tyr Glu Ala Asp Leu 
705                 710                 715                 720 


Gln Tyr Arg Val Thr Leu Asp Ser Leu Arg Gln Ile Ser Arg Ser Phe 
                725                 730                 735     


Phe Ser Gly Thr Gln Glu Arg Lys Val Gln Arg Asn Ile Thr Val Arg 
            740                 745                 750         


Lys Ser Glu Cys Thr Lys His Ser Phe Tyr Met Leu Asp Lys His Asp 
        755                 760                 765             


Phe Gln Asp Ser Val Arg Ile Thr Leu Asp Phe Asn Leu Thr Asp Pro 
    770                 775                 780                 


Glu Asn Gly Pro Val Leu Asp Asp Ser Leu Pro Asn Ser Val His Glu 
785                 790                 795                 800 


Tyr Ile Pro Phe Ala Lys Asp Cys Gly Asn Lys Glu Lys Cys Ile Ser 
                805                 810                 815     


Asp Leu Ser Leu His Val Ala Thr Thr Glu Lys Asp Leu Leu Ile Val 
            820                 825                 830         


Arg Ser Gln Asn Asp Lys Phe Asn Val Ser Leu Thr Val Lys Asn Thr 
        835                 840                 845             


Lys Asp Ser Ala Tyr Asn Thr Arg Thr Ile Val His Tyr Ser Pro Asn 
    850                 855                 860                 


Leu Val Phe Ser Gly Ile Glu Ala Ile Gln Lys Asp Ser Cys Glu Ser 
865                 870                 875                 880 


Asn His Asn Ile Thr Cys Lys Val Gly Tyr Pro Phe Leu Arg Arg Gly 
                885                 890                 895     


Glu Met Val Thr Phe Lys Ile Leu Phe Gln Phe Asn Thr Ser Tyr Leu 
            900                 905                 910         


Met Glu Asn Val Thr Ile Tyr Leu Ser Ala Thr Ser Asp Ser Glu Glu 
        915                 920                 925             


Pro Pro Glu Thr Leu Ser Asp Asn Val Val Asn Ile Ser Ile Pro Val 
    930                 935                 940                 


Lys Tyr Glu Val Gly Leu Gln Phe Tyr Ser Ser Ala Ser Glu Tyr His 
945                 950                 955                 960 


Ile Ser Ile Ala Ala Asn Glu Thr Val Pro Glu Val Ile Asn Ser Thr 
                965                 970                 975     


Glu Asp Ile Gly Asn Glu Ile Asn Ile Phe Tyr Leu Ile Arg Lys Ser 
            980                 985                 990         


Gly Ser Phe Pro Met Pro Glu Leu  Lys Leu Ser Ile Ser  Phe Pro Asn 
        995                 1000                 1005             


Met Thr  Ser Asn Gly Tyr Pro  Val Leu Tyr Pro Thr  Gly Leu Ser 
    1010                 1015                 1020             


Ser Ser  Glu Asn Ala Asn Cys  Arg Pro His Ile Phe  Glu Asp Pro 
    1025                 1030                 1035             


Phe Ser  Ile Asn Ser Gly Lys  Lys Met Thr Thr Ser  Thr Asp His 
    1040                 1045                 1050             


Leu Lys  Arg Gly Thr Ile Leu  Asp Cys Asn Thr Cys  Lys Phe Ala 
    1055                 1060                 1065             


Thr Ile  Thr Cys Asn Leu Thr  Ser Ser Asp Ile Ser  Gln Val Asn 
    1070                 1075                 1080             


Val Ser  Leu Ile Leu Trp Lys  Pro Thr Phe Ile Lys  Ser Tyr Phe 
    1085                 1090                 1095             


Ser Ser  Leu Asn Leu Thr Ile  Arg Gly Glu Leu Arg  Ser Glu Asn 
    1100                 1105                 1110             


Ala Ser  Leu Val Leu Ser Ser  Ser Asn Gln Lys Arg  Glu Leu Ala 
    1115                 1120                 1125             


Ile Gln  Ile Ser Lys Asp Gly  Leu Pro Gly Arg Val  Pro Leu Trp 
    1130                 1135                 1140             


Val Ile  Leu Leu Ser Ala Phe  Ala Gly Leu Leu Leu  Leu Met Leu 
    1145                 1150                 1155             


Leu Ile  Leu Ala Leu Trp Lys  Ile Gly Phe Phe Lys  Arg Pro Leu 
    1160                 1165                 1170             


Lys Lys  Lys Met Glu Lys 
    1175                 


<210> 4
<211> 106
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 4
Gln Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Asn His Met 
            20                  25                  30          


Phe Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Gly Asn Pro Trp Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210> 5
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 5
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly His Thr Tyr Tyr Leu Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Gly Phe Gly Asp Gly Gly Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210> 6
<211> 3540
<212> DNA
<213> Homo sapiens


<220>
<221> CDS
<222> (1)..(3537)

<400> 6
atg gcc cct cgg ccc cgc gcc cgc cca ggg gtc gct gtc gcc tgc tgc         48
Met Ala Pro Arg Pro Arg Ala Arg Pro Gly Val Ala Val Ala Cys Cys           
1               5                   10                  15                

tgg ctc ctc act gtt gtt cta cgc tgc tgc gta tca ttc aat gtt gat         96
Trp Leu Leu Thr Val Val Leu Arg Cys Cys Val Ser Phe Asn Val Asp           
            20                  25                  30                    

gtg aaa aat tca atg act ttc agc ggc ccg gtg gaa gac atg ttt gga        144
Val Lys Asn Ser Met Thr Phe Ser Gly Pro Val Glu Asp Met Phe Gly           
        35                  40                  45                        

tat act gtt caa caa tat gaa aat gaa gaa gga aaa tgg gtg ctt att        192
Tyr Thr Val Gln Gln Tyr Glu Asn Glu Glu Gly Lys Trp Val Leu Ile           
    50                  55                  60                            

ggt tct ccg tta gtt ggc caa ccc aaa aac aga act gga gat gtc tat        240
Gly Ser Pro Leu Val Gly Gln Pro Lys Asn Arg Thr Gly Asp Val Tyr           
65                  70                  75                  80            

aag tgt cca gtt ggg aga ggt gaa tca tta cct tgt gta aag ttg gat        288
Lys Cys Pro Val Gly Arg Gly Glu Ser Leu Pro Cys Val Lys Leu Asp           
                85                  90                  95                

cta cca gtt aat aca tca att ccc aat gtc aca gaa gta aag gag aac        336
Leu Pro Val Asn Thr Ser Ile Pro Asn Val Thr Glu Val Lys Glu Asn           
            100                 105                 110                   

atg aca ttt gga tca act tta gtc acc aac cca aat gga gga ttt ctg        384
Met Thr Phe Gly Ser Thr Leu Val Thr Asn Pro Asn Gly Gly Phe Leu           
        115                 120                 125                       

gct tgt ggg ccc tta tat gcc tat aga tgt gga cat ttg cat tac aca        432
Ala Cys Gly Pro Leu Tyr Ala Tyr Arg Cys Gly His Leu His Tyr Thr           
    130                 135                 140                           

act gga atc tgt tct gac gtc agc ccc aca ttt caa gtc gtg aat tcc        480
Thr Gly Ile Cys Ser Asp Val Ser Pro Thr Phe Gln Val Val Asn Ser           
145                 150                 155                 160           

att gcc cct gta caa gaa tgc agc act caa ctg gac ata gtc ata gtg        528
Ile Ala Pro Val Gln Glu Cys Ser Thr Gln Leu Asp Ile Val Ile Val           
                165                 170                 175               

ctg gat ggt tcc aac agt att tac cca tgg gac agt gtt aca gct ttt        576
Leu Asp Gly Ser Asn Ser Ile Tyr Pro Trp Asp Ser Val Thr Ala Phe           
            180                 185                 190                   

tta aat gac ctt ctt gaa aga atg gat att ggt cct aaa cag aca cag        624
Leu Asn Asp Leu Leu Glu Arg Met Asp Ile Gly Pro Lys Gln Thr Gln           
        195                 200                 205                       

gtt gga att gta cag tat gga gaa aac gtg acc cat gag ttc aac ctc        672
Val Gly Ile Val Gln Tyr Gly Glu Asn Val Thr His Glu Phe Asn Leu           
    210                 215                 220                           

aat aag tat tct tcc acc gaa gag gta ctt gtt gca gca aag aaa ata        720
Asn Lys Tyr Ser Ser Thr Glu Glu Val Leu Val Ala Ala Lys Lys Ile           
225                 230                 235                 240           

gtc cag aga ggt ggc cgc cag act atg aca gct ctt gga ata gac aca        768
Val Gln Arg Gly Gly Arg Gln Thr Met Thr Ala Leu Gly Ile Asp Thr           
                245                 250                 255               

gca aga aag gag gca ttc acg gaa gcc cgg ggt gcc cga aga gga gtt        816
Ala Arg Lys Glu Ala Phe Thr Glu Ala Arg Gly Ala Arg Arg Gly Val           
            260                 265                 270                   

aaa aaa gtc atg gtt att gtg aca gat gga gag tct cat gac aat cat        864
Lys Lys Val Met Val Ile Val Thr Asp Gly Glu Ser His Asp Asn His           
        275                 280                 285                       

cga ctg aag aag gtc atc caa gac tgt gaa gat gaa aac att caa cgg        912
Arg Leu Lys Lys Val Ile Gln Asp Cys Glu Asp Glu Asn Ile Gln Arg           
    290                 295                 300                           

ttt tcc ata gct att ctt ggc agc tat aac cga gga aat tta agc act        960
Phe Ser Ile Ala Ile Leu Gly Ser Tyr Asn Arg Gly Asn Leu Ser Thr           
305                 310                 315                 320           

gaa aaa ttt gtg gag gaa ata aaa tca att gca agt gaa ccc act gaa       1008
Glu Lys Phe Val Glu Glu Ile Lys Ser Ile Ala Ser Glu Pro Thr Glu           
                325                 330                 335               

aag cat ttc ttc aat gtc tct gat gaa ttg gct cta gtc acc att gtt       1056
Lys His Phe Phe Asn Val Ser Asp Glu Leu Ala Leu Val Thr Ile Val           
            340                 345                 350                   

aaa act ctg gga gaa aga ata ttt gcc ctg gaa gcc aca gct gac cag       1104
Lys Thr Leu Gly Glu Arg Ile Phe Ala Leu Glu Ala Thr Ala Asp Gln           
        355                 360                 365                       

tca gca gct tca ttt gaa atg gaa atg tct cag act ggc ttc agt gct       1152
Ser Ala Ala Ser Phe Glu Met Glu Met Ser Gln Thr Gly Phe Ser Ala           
    370                 375                 380                           

cat tat tca cag gac tgg gtc atg ctt gga gca gta gga gcc tat gat       1200
His Tyr Ser Gln Asp Trp Val Met Leu Gly Ala Val Gly Ala Tyr Asp           
385                 390                 395                 400           

tgg aat gga aca gtt gtc atg cag aag gct agt caa atc ata atc cct       1248
Trp Asn Gly Thr Val Val Met Gln Lys Ala Ser Gln Ile Ile Ile Pro           
                405                 410                 415               

cga aac aca acc ttt aat gtt gag tct acc aaa aag aat gaa ccg ctt       1296
Arg Asn Thr Thr Phe Asn Val Glu Ser Thr Lys Lys Asn Glu Pro Leu           
            420                 425                 430                   

gct tct tat tta ggt tac act gta aac tct gct act gct tct tct gga       1344
Ala Ser Tyr Leu Gly Tyr Thr Val Asn Ser Ala Thr Ala Ser Ser Gly           
        435                 440                 445                       

gat gtg ctc tat att gct gga cag cct cgg tac aat cat aca ggc cag       1392
Asp Val Leu Tyr Ile Ala Gly Gln Pro Arg Tyr Asn His Thr Gly Gln           
    450                 455                 460                           

gtc att atc tac agg atg gaa gat gga aac atc aaa att ctc cag acg       1440
Val Ile Ile Tyr Arg Met Glu Asp Gly Asn Ile Lys Ile Leu Gln Thr           
465                 470                 475                 480           

ctc agt gga gaa cag att ggt tcc tac ttt ggc agt att tta aca aca       1488
Leu Ser Gly Glu Gln Ile Gly Ser Tyr Phe Gly Ser Ile Leu Thr Thr           
                485                 490                 495               

act gac att gac aag gat tct aat act gac att ctt cta gtc gga gcc       1536
Thr Asp Ile Asp Lys Asp Ser Asn Thr Asp Ile Leu Leu Val Gly Ala           
            500                 505                 510                   

cct atg tac atg gga aca gag aag gag gag caa gga aaa gtg tat gtg       1584
Pro Met Tyr Met Gly Thr Glu Lys Glu Glu Gln Gly Lys Val Tyr Val           
        515                 520                 525                       

tat gct ctc aat cag aca agg ttt gaa tat caa atg agc ctg gaa cct       1632
Tyr Ala Leu Asn Gln Thr Arg Phe Glu Tyr Gln Met Ser Leu Glu Pro           
    530                 535                 540                           

att aag cag acg tgc tgt tca tct cgg cag cac aat tca tgc aca aca       1680
Ile Lys Gln Thr Cys Cys Ser Ser Arg Gln His Asn Ser Cys Thr Thr           
545                 550                 555                 560           

gaa aac aaa aat gag cca tgc ggg gct cgt ttt gga act gca att gct       1728
Glu Asn Lys Asn Glu Pro Cys Gly Ala Arg Phe Gly Thr Ala Ile Ala           
                565                 570                 575               

gct gta aaa gac ctc aat ctt gat gga ttt aat gac atc gtg ata gga       1776
Ala Val Lys Asp Leu Asn Leu Asp Gly Phe Asn Asp Ile Val Ile Gly           
            580                 585                 590                   

gct ccg ctg gaa gat gat cac ggg gga gct gtg tac att tat cat gga       1824
Ala Pro Leu Glu Asp Asp His Gly Gly Ala Val Tyr Ile Tyr His Gly           
        595                 600                 605                       

agt ggc aag act ata agg aaa gag tat gca caa cgt att cca tca ggt       1872
Ser Gly Lys Thr Ile Arg Lys Glu Tyr Ala Gln Arg Ile Pro Ser Gly           
    610                 615                 620                           

ggg gat ggt aag aca ctg aaa ttt ttt ggc cag tct atc cac gga gaa       1920
Gly Asp Gly Lys Thr Leu Lys Phe Phe Gly Gln Ser Ile His Gly Glu           
625                 630                 635                 640           

atg gat tta aat ggt gac ggt ctg aca gat gtg act att ggg ggc ctt       1968
Met Asp Leu Asn Gly Asp Gly Leu Thr Asp Val Thr Ile Gly Gly Leu           
                645                 650                 655               

ggt ggt gct gcc ctc ttc tgg tcc cga gat gtg gcc gta gtt aaa gtg       2016
Gly Gly Ala Ala Leu Phe Trp Ser Arg Asp Val Ala Val Val Lys Val           
            660                 665                 670                   

acc atg aat ttt gag cca aat aaa gtg aat att caa aag aaa aac tgc       2064
Thr Met Asn Phe Glu Pro Asn Lys Val Asn Ile Gln Lys Lys Asn Cys           
        675                 680                 685                       

cat atg gag gga aag gaa aca gta tgc ata aat gct aca gtg tgt ttt       2112
His Met Glu Gly Lys Glu Thr Val Cys Ile Asn Ala Thr Val Cys Phe           
    690                 695                 700                           

gat gtg aaa tta aag tct aaa gaa gac acg att tat gaa gct gat ttg       2160
Asp Val Lys Leu Lys Ser Lys Glu Asp Thr Ile Tyr Glu Ala Asp Leu           
705                 710                 715                 720           

cag tac cgt gtc acc cta gat tca cta aga caa ata tca cga agt ttt       2208
Gln Tyr Arg Val Thr Leu Asp Ser Leu Arg Gln Ile Ser Arg Ser Phe           
                725                 730                 735               

ttc tct gga act caa gag aga aag gtt caa agg aac atc aca gtt cga       2256
Phe Ser Gly Thr Gln Glu Arg Lys Val Gln Arg Asn Ile Thr Val Arg           
            740                 745                 750                   

aaa tca gaa tgc act aag cac tcc ttc tac atg ttg gac aag cat gac       2304
Lys Ser Glu Cys Thr Lys His Ser Phe Tyr Met Leu Asp Lys His Asp           
        755                 760                 765                       

ttt cag gac tct gtg aga ata acg ttg gac ttt aat ctt acc gat cca       2352
Phe Gln Asp Ser Val Arg Ile Thr Leu Asp Phe Asn Leu Thr Asp Pro           
    770                 775                 780                           

gaa aat ggg cct gtt ctt gat gat tct cta cca aac tca gta cat gaa       2400
Glu Asn Gly Pro Val Leu Asp Asp Ser Leu Pro Asn Ser Val His Glu           
785                 790                 795                 800           

tat att ccc ttt gcc aaa gat tgt gga aat aag gaa aaa tgt atc tca       2448
Tyr Ile Pro Phe Ala Lys Asp Cys Gly Asn Lys Glu Lys Cys Ile Ser           
                805                 810                 815               

gac ctc agc ctg cat gtc gcc acc act gaa aag gac ctg ctg att gtc       2496
Asp Leu Ser Leu His Val Ala Thr Thr Glu Lys Asp Leu Leu Ile Val           
            820                 825                 830                   

cga tcc cag aat gat aag ttc aac gtt agc ctc aca gtc aaa aat aca       2544
Arg Ser Gln Asn Asp Lys Phe Asn Val Ser Leu Thr Val Lys Asn Thr           
        835                 840                 845                       

aag gac agt gcc tat aac acc agg aca ata gtg cat tat tct cca aat       2592
Lys Asp Ser Ala Tyr Asn Thr Arg Thr Ile Val His Tyr Ser Pro Asn           
    850                 855                 860                           

cta gtt ttt tca gga att gag gct atc caa aaa gac agt tgt gaa tct       2640
Leu Val Phe Ser Gly Ile Glu Ala Ile Gln Lys Asp Ser Cys Glu Ser           
865                 870                 875                 880           

aat cat aat atc aca tgt aaa gtt gga tat ccc ttc ctg aga aga gga       2688
Asn His Asn Ile Thr Cys Lys Val Gly Tyr Pro Phe Leu Arg Arg Gly           
                885                 890                 895               

gag atg gta act ttc aaa ata ttg ttt cag ttt aac aca tcc tat ctc       2736
Glu Met Val Thr Phe Lys Ile Leu Phe Gln Phe Asn Thr Ser Tyr Leu           
            900                 905                 910                   

atg gaa aat gtg acc att tat tta agt gca aca agt gac agc gaa gaa       2784
Met Glu Asn Val Thr Ile Tyr Leu Ser Ala Thr Ser Asp Ser Glu Glu           
        915                 920                 925                       

cct cct gaa acc ctt tct gat aat gta gta aac att tct atc ccg gta       2832
Pro Pro Glu Thr Leu Ser Asp Asn Val Val Asn Ile Ser Ile Pro Val           
    930                 935                 940                           

aaa tat gaa gtt gga cta cag ttt tac agc tct gca agt gaa tac cac       2880
Lys Tyr Glu Val Gly Leu Gln Phe Tyr Ser Ser Ala Ser Glu Tyr His           
945                 950                 955                 960           

att tca att gct gcc aat gag aca gtc cct gaa gtt att aat tct act       2928
Ile Ser Ile Ala Ala Asn Glu Thr Val Pro Glu Val Ile Asn Ser Thr           
                965                 970                 975               

gag gac att gga aat gaa att aat atc ttc tac ttg att aga aaa agt       2976
Glu Asp Ile Gly Asn Glu Ile Asn Ile Phe Tyr Leu Ile Arg Lys Ser           
            980                 985                 990                   

gga tct ttt cca atg cca gag ctt  aag ctg tca att tca  ttc ccc aat     3024
Gly Ser Phe Pro Met Pro Glu Leu  Lys Leu Ser Ile Ser  Phe Pro Asn         
        995                 1000                 1005                     

atg aca  tca aat ggt tac cct  gtg ctg tac cca act  gga ttg tca        3069
Met Thr  Ser Asn Gly Tyr Pro  Val Leu Tyr Pro Thr  Gly Leu Ser            
    1010                 1015                 1020                        

tct tct  gag aat gca aac tgc  aga ccc cat atc ttt  gag gat cct        3114
Ser Ser  Glu Asn Ala Asn Cys  Arg Pro His Ile Phe  Glu Asp Pro            
    1025                 1030                 1035                        

ttc agt  atc aac tct gga aag  aaa atg act aca tca  act gac cat        3159
Phe Ser  Ile Asn Ser Gly Lys  Lys Met Thr Thr Ser  Thr Asp His            
    1040                 1045                 1050                        

ctc aaa  cga ggc aca att ctg  gac tgc aat aca tgt  aaa ttt gct        3204
Leu Lys  Arg Gly Thr Ile Leu  Asp Cys Asn Thr Cys  Lys Phe Ala            
    1055                 1060                 1065                        

acc atc  aca tgt aat ctc act  tct tct gac atc agc  caa gtc aat        3249
Thr Ile  Thr Cys Asn Leu Thr  Ser Ser Asp Ile Ser  Gln Val Asn            
    1070                 1075                 1080                        

gtt tcg  ctt atc ttg tgg aaa  cca act ttt ata aaa  tca tat ttt        3294
Val Ser  Leu Ile Leu Trp Lys  Pro Thr Phe Ile Lys  Ser Tyr Phe            
    1085                 1090                 1095                        

tcc agc  tta aat ctt act ata  agg gga gaa ctt cgg  agt gaa aat        3339
Ser Ser  Leu Asn Leu Thr Ile  Arg Gly Glu Leu Arg  Ser Glu Asn            
    1100                 1105                 1110                        

gca tct  ctg gtt tta agt agc  agc aat caa aaa aga  gag ctt gct        3384
Ala Ser  Leu Val Leu Ser Ser  Ser Asn Gln Lys Arg  Glu Leu Ala            
    1115                 1120                 1125                        

att caa  ata tcc aaa gat ggg  cta ccg ggc aga gtg  cca tta tgg        3429
Ile Gln  Ile Ser Lys Asp Gly  Leu Pro Gly Arg Val  Pro Leu Trp            
    1130                 1135                 1140                        

gtc atc  ctg ctg agt gct ttt  gcc gga ttg ttg ctg  tta atg ctg        3474
Val Ile  Leu Leu Ser Ala Phe  Ala Gly Leu Leu Leu  Leu Met Leu            
    1145                 1150                 1155                        

ctc att  tta gca ctg tgg aag  att gga ttc ttc aaa  aga cca ctg        3519
Leu Ile  Leu Ala Leu Trp Lys  Ile Gly Phe Phe Lys  Arg Pro Leu            
    1160                 1165                 1170                        

aaa aag  aaa atg gag aaa tga                                          3540
Lys Lys  Lys Met Glu Lys                                                  
    1175                                                                  


