                         SEQUENCE LISTING

<110>  Bramhill, David
       Gehlsen, Kurt R.
 
<120>  FUSION PROTEINS COMPRISING IMMUNOGLOBULIN CONSTANT DOMAIN-DERIVED
        SCAFFOLDS

<130>  29645

<140>  To be Assigned
<141>  2013-02-08

<150>  61/597,478
<151>  2012-02-09

<150>  13/370,831
<151>  2012-02-10

<160>  37    

<170>  PatentIn version 3.5

<210>  1
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Synthetic or Engineered CH2 Scaffold Protein

<400>  1

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser Gln Glu Asp Pro Asp Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asn Gly Ala Glu Val His His Ala Gln Thr Lys Pro Arg Glu Thr 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Thr His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Thr Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Gln Lys Thr Ile Ser Lys Asp Lys 
            100                 105                 110 


<210>  2
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Synthetic or Engineered CH2 Scaffold Protein

<400>  2

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  3
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Synthetic or Engineered CH2 Scaffold Protein

<400>  3

His His His His His His Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
1               5                   10                  15      


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            20                  25                  30          


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Asp 
        35                  40                  45              


Val Lys Phe Asn Trp Tyr Val Asn Gly Ala Glu Val His His Ala Gln 
    50                  55                  60                  


Thr Lys Pro Arg Glu Thr Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
65                  70                  75                  80  


Val Leu Thr Val Thr His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Thr 
                85                  90                  95      


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Gln Lys Thr Ile 
            100                 105                 110         


Ser Lys Asp Lys 
        115     


<210>  4
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Synthetic or Engineered CH2 Scaffold Protein

<400>  4

His His His His His His Ser Gly Pro Ser Val Phe Cys Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Val Ser Gln Glu Asp Pro Asp Val Lys Phe Asn Trp 
        35                  40                  45              


Tyr Val Asn Gly Ala Glu Val His His Ala Gln Thr Lys Pro Arg Glu 
    50                  55                  60                  


Thr Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Thr 
65                  70                  75                  80  


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Thr Cys Lys Val Ser Asn 
                85                  90                  95      


Lys Ala Leu Pro Ala Pro Ile Gln Cys Thr Ile Ser Lys Asp Lys 
            100                 105                 110     


<210>  5
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Synthetic or Engineered CH2 Scaffold Protein

<400>  5

His His His His His His Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
1               5                   10                  15      


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            20                  25                  30          


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Asp 
        35                  40                  45              


Val Lys Phe Asn Trp Tyr Val Asp Gly Ala Glu Val His His Ala Gln 
    50                  55                  60                  


Thr Lys Pro Arg Glu Thr Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
65                  70                  75                  80  


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                85                  90                  95      


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            100                 105                 110         


Ser Lys Ala Lys 
        115     


<210>  6
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Synthetic or Engineered CH2 Scaffold Protein

<400>  6

His His His His His His Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
1               5                   10                  15      


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            20                  25                  30          


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Asp 
        35                  40                  45              


Val Lys Phe Asn Trp Tyr Val Asp Gly Ala Glu Val His His Ala Gln 
    50                  55                  60                  


Thr Lys Pro Arg Glu Thr Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
65                  70                  75                  80  


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                85                  90                  95      


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            100                 105                 110         


Ser Lys Asp Lys 
        115     


<210>  7
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Synthetic or Engineered CH2 Scaffold Protein

<400>  7

His His His His His His Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
1               5                   10                  15      


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            20                  25                  30          


Pro Glu Val Thr Cys Val Val Val Gly Tyr Ser Ile Thr Ser Asp Phe 
        35                  40                  45              


Ala Phe Asn Trp Tyr Val Asp Gly Ala Glu Val His His Ala Gln Thr 
    50                  55                  60                  


Lys Pro Arg Ile Tyr Trp Asp Asp Asp Lys Thr Tyr Arg Val Val Ser 
65                  70                  75                  80  


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                85                  90                  95      


Cys Lys Val Ala Thr Ala Gly Arg Gly Phe Pro Tyr Glu Lys Thr Ile 
            100                 105                 110         


Ser Lys Ala Lys 
        115     


<210>  8
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Synthetic or Engineered CH2 Scaffold Protein

<400>  8

His His His His His His Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
1               5                   10                  15      


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            20                  25                  30          


Pro Glu Val Thr Cys Val Val Val Ala Arg Thr Leu Arg Val Ser Gly 
        35                  40                  45              


Asp Tyr Val Arg Asp Phe Asp Leu Phe Asn Trp Tyr Val Asp Gly Ala 
    50                  55                  60                  


Glu Val His His Ala Gln Thr Lys Pro Arg Ile Tyr Trp Asp Asp Asp 
65                  70                  75                  80  


Lys Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                85                  90                  95      


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Gly Phe Ser Leu Ser Thr 
            100                 105                 110         


Ser Gly Met Ser Glu Lys Thr Ile Ser Lys Ala Lys 
        115                 120                 


<210>  9
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Synthetic or Engineered CH2 Scaffold Protein

<400>  9

His His His His His His Ser Gly Pro Ser Val Phe Cys Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Val Ser Gln Glu Asp Pro Asp Val Lys Phe Asn Trp 
        35                  40                  45              


Tyr Val Asp Gly Ala Glu Val His His Ala Gln Thr Lys Pro Arg Glu 
    50                  55                  60                  


Thr Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
65                  70                  75                  80  


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                85                  90                  95      


Lys Ala Leu Pro Ala Pro Ile Glu Cys Thr Ile Ser Lys Ala Lys 
            100                 105                 110     


<210>  10
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Synthetic or Engineered CH2 Scaffold Protein

<400>  10

His His His His His His Ala Pro Glu Leu Leu Gly Gly Pro Ser Cys 
1               5                   10                  15      


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            20                  25                  30          


Pro Glu Val Thr Cys Val Val Val Gly Tyr Ser Ile Thr Ser Asp Phe 
        35                  40                  45              


Ala Phe Asn Trp Tyr Val Asp Gly Ala Glu Val His His Ala Gln Thr 
    50                  55                  60                  


Lys Pro Arg Ile Tyr Trp Asp Asp Asp Lys Thr Tyr Arg Val Val Ser 
65                  70                  75                  80  


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                85                  90                  95      


Cys Lys Val Ala Thr Ala Gly Arg Gly Phe Pro Cys Glu Lys Thr Ile 
            100                 105                 110         


Ser Lys Ala Lys 
        115     


<210>  11
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Synthetic or Engineered CH2 Scaffold Protein

<400>  11

His His His His His His Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
1               5                   10                  15      


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            20                  25                  30          


Pro Glu Val Thr Cys Val Val Val Ser Ser Asn Ile Gly Ala Gly Tyr 
        35                  40                  45              


Asp Phe Asn Trp Tyr Val Asp Gly Ala Glu Val His His Ala Gln Thr 
    50                  55                  60                  


Lys Pro Arg Ile Tyr Trp Asp Asp Asp Lys Thr Tyr Arg Val Val Ser 
65                  70                  75                  80  


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                85                  90                  95      


Cys Lys Val Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val Glu Lys 
            100                 105                 110         


Thr Ile Ser Lys Ala Lys 
        115             


<210>  12
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Synthetic or Engineered CH2 Scaffold Protein

<400>  12

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Gly Tyr Ser Ile Thr Ser Asp Phe Ala Phe Asn Trp Tyr Val 
        35                  40                  45              


Asp Gly Ala Glu Val His His Ala Gln Thr Lys Pro Arg Ile Tyr Trp 
    50                  55                  60                  


Asp Asp Asp Lys Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ala Thr Ala 
                85                  90                  95      


Gly Arg Gly Phe Pro Tyr Glu Lys Thr Ile Ser Lys Ala Lys Gly Ser 
            100                 105                 110         


His His His His His His 
        115             


<210>  13
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Synthetic or Engineered CH2 Scaffold Protein

<400>  13

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Ser Ser Asn Ile Gly Ala Gly Tyr Asp Phe Asn Trp Tyr Val 
        35                  40                  45              


Asn Gly Ala Glu Val His His Ala Gln Thr Lys Pro Arg Glu Thr Gln 
    50                  55                  60                  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Thr His Gln 
65                  70                  75                  80  


Asp Trp Leu Asn Gly Lys Glu Tyr Thr Cys Lys Val Gln Ser Tyr Asp 
                85                  90                  95      


Ser Ser Leu Ser Gly Ser Val Gln Lys Thr Ile Ser Lys Asp Lys Gly 
            100                 105                 110         


Ser His His His His His His 
        115                 


<210>  14
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Synthetic or Engineered CH2 Scaffold Protein

<400>  14

Gly Pro Ser Val Phe Cys Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
1               5                   10                  15      


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Ser Ser Asn Ile 
            20                  25                  30          


Gly Ala Gly Tyr Asp Phe Asn Trp Tyr Val Asn Gly Ala Glu Val His 
        35                  40                  45              


His Ala Gln Thr Lys Pro Arg Glu Thr Gln Tyr Asn Ser Thr Tyr Arg 
    50                  55                  60                  


Val Val Ser Val Leu Thr Val Thr His Gln Asp Trp Leu Asn Gly Lys 
65                  70                  75                  80  


Glu Tyr Thr Cys Lys Val Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser 
                85                  90                  95      


Val Gln Cys Thr Ile Ser Lys Asp Lys Gly Ser His His His His His 
            100                 105                 110         


His 
    


<210>  15
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Synthetic or Engineered CH2 Scaffold Protein

<400>  15

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Ser Ser Asn Ile Gly Ala Gly Tyr Asp Phe Asn Trp Tyr Val 
        35                  40                  45              


Asn Gly Ala Glu Val His His Ala Gln Thr Lys Pro Arg Ile Tyr Trp 
    50                  55                  60                  


Asp Asp Asp Lys Thr Tyr Arg Val Val Ser Val Leu Thr Val Thr His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Thr Cys Lys Val Gln Ser Tyr 
                85                  90                  95      


Asp Ser Ser Leu Ser Gly Ser Val Gln Lys Thr Ile Ser Lys Asp Lys 
            100                 105                 110         


Gly Ser His His His His His His 
        115                 120 


<210>  16
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Synthetic or Engineered CH2 Scaffold Protein

<400>  16

Ala Pro Glu Leu Leu Gly Gly Pro Ser Cys Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Ser Ser Asn Ile Gly Ala Gly Tyr Asp Phe Asn Trp Tyr Val 
        35                  40                  45              


Asn Gly Ala Glu Val His His Ala Gln Thr Lys Pro Arg Glu Thr Gln 
    50                  55                  60                  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Thr His Gln 
65                  70                  75                  80  


Asp Trp Leu Asn Gly Lys Glu Tyr Thr Cys Lys Val Gln Ser Tyr Asp 
                85                  90                  95      


Ser Ser Leu Ser Gly Ser Cys Gln Lys Thr Ile Ser Lys Asp Lys Gly 
            100                 105                 110         


Ser His His His His His His 
        115                 


<210>  17
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Synthetic or Engineered CH2 Scaffold Protein

<400>  17

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Ala Arg Thr Leu Arg Val Ser Gly Asp Tyr Val Arg Asp Phe 
        35                  40                  45              


Asp Leu Phe Asn Trp Tyr Val Asn Gly Ala Glu Val His His Ala Gln 
    50                  55                  60                  


Thr Lys Pro Arg Glu Thr Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
65                  70                  75                  80  


Val Leu Thr Val Thr His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Thr 
                85                  90                  95      


Cys Lys Val Gly Phe Ser Leu Ser Thr Ser Gly Met Ser Gln Lys Thr 
            100                 105                 110         


Ile Ser Lys Asp Lys Gly Ser His His His His His His 
        115                 120                 125 


<210>  18
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Synthetic or Engineered CH2 Scaffold Protein

<400>  18

Gly Pro Ser Val Phe Cys Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
1               5                   10                  15      


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Arg Thr Leu 
            20                  25                  30          


Arg Val Ser Gly Asp Tyr Val Arg Asp Phe Asp Leu Phe Asn Trp Tyr 
        35                  40                  45              


Val Asn Gly Ala Glu Val His His Ala Gln Thr Lys Pro Arg Glu Thr 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Thr His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Thr Cys Lys Val Gly Phe Ser 
                85                  90                  95      


Leu Ser Thr Ser Gly Met Ser Gln Cys Thr Ile Ser Lys Asp Lys Gly 
            100                 105                 110         


Ser His His His His His His 
        115                 


<210>  19
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Synthetic or Engineered CH2 Scaffold Protein

<400>  19

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Ala Arg Thr Leu Arg Val Ser Gly Asp Tyr Val Arg Asp Phe 
        35                  40                  45              


Asp Leu Phe Asn Trp Tyr Val Asn Gly Ala Glu Val His His Ala Gln 
    50                  55                  60                  


Thr Lys Pro Arg Ile Tyr Trp Asp Asp Asp Lys Thr Tyr Arg Val Val 
65                  70                  75                  80  


Ser Val Leu Thr Val Thr His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                85                  90                  95      


Thr Cys Lys Val Gly Phe Ser Leu Ser Thr Ser Gly Met Ser Gln Lys 
            100                 105                 110         


Thr Ile Ser Lys Asp Lys Gly Ser His His His His His His 
        115                 120                 125     


<210>  20
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Synthetic or Engineered CH2 Scaffold Protein

<400>  20

Ala Pro Glu Leu Leu Gly Gly Pro Ser Cys Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Ala Arg Thr Leu Arg Val Ser Gly Asp Tyr Val Arg Asp Phe 
        35                  40                  45              


Asp Leu Phe Asn Trp Tyr Val Asn Gly Ala Glu Val His His Ala Gln 
    50                  55                  60                  


Thr Lys Pro Arg Glu Thr Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
65                  70                  75                  80  


Val Leu Thr Val Thr His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Thr 
                85                  90                  95      


Cys Lys Val Gly Phe Ser Leu Ser Thr Ser Gly Met Cys Gln Lys Thr 
            100                 105                 110         


Ile Ser Lys Asp Lys Gly Ser His His His His His His 
        115                 120                 125 


<210>  21
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Synthetic or Engineered CH2 Scaffold Protein

<400>  21

Ala Pro Glu Leu Leu Gly Gly Pro Ser Cys Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser Gln Glu Asp Pro Asp Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asn Gly Ala Glu Val His His Ala Gln Thr Lys Pro Arg Glu Thr 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Thr His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Thr Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Cys Gln Lys Thr Ile Ser Lys Asp Lys Gly Ser 
            100                 105                 110         


His His His His His His 
        115             


<210>  22
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Synthetic or Engineered CH2 Scaffold Protein

<400>  22

Gly Pro Ser Cys Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
1               5                   10                  15      


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
            20                  25                  30          


Glu Asp Pro Asp Val Lys Phe Asn Trp Tyr Val Asn Gly Ala Glu Val 
        35                  40                  45              


His His Ala Gln Thr Lys Pro Arg Glu Thr Gln Tyr Asn Ser Thr Tyr 
    50                  55                  60                  


Arg Val Val Ser Val Leu Thr Val Thr His Gln Asp Trp Leu Asn Gly 
65                  70                  75                  80  


Lys Glu Tyr Thr Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Cys 
                85                  90                  95      


Gln Lys Thr Ile Ser Lys Asp Lys Gly Ser His His His His His His 
            100                 105                 110         


<210>  23
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Synthetic or Engineered CH2 Scaffold Protein

<400>  23

Gly Pro Ser Val Phe Cys Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
1               5                   10                  15      


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Arg Thr Leu 
            20                  25                  30          


Arg Val Ser Gly Asp Tyr Val Arg Asp Phe Asp Leu Phe Asn Trp Tyr 
        35                  40                  45              


Val Asn Gly Ala Glu Val His His Ala Gln Thr Lys Pro Arg Ile Tyr 
    50                  55                  60                  


Trp Asp Asp Asp Lys Thr Tyr Arg Val Val Ser Val Leu Thr Val Thr 
65                  70                  75                  80  


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Thr Cys Lys Val Gly Phe 
                85                  90                  95      


Ser Leu Ser Thr Ser Gly Met Ser Gln Cys Thr Ile Ser Lys Asp Lys 
            100                 105                 110         


Gly Ser His His His His His His 
        115                 120 


<210>  24
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Synthetic or Engineered CH2 Scaffold Protein

<400>  24

Gly Pro Ser Cys Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
1               5                   10                  15      


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Ser Ser Asn Ile 
            20                  25                  30          


Gly Ala Gly Tyr Asp Phe Asn Trp Tyr Val Asn Gly Ala Glu Val His 
        35                  40                  45              


His Ala Gln Thr Lys Pro Arg Glu Thr Gln Tyr Asn Ser Thr Tyr Arg 
    50                  55                  60                  


Val Val Ser Val Leu Thr Val Thr His Gln Asp Trp Leu Asn Gly Lys 
65                  70                  75                  80  


Glu Tyr Thr Cys Lys Val Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser 
                85                  90                  95      


Cys Gln Lys Thr Ile Ser Lys Asp Lys Gly Ser His His His His His 
            100                 105                 110         


His 
    


<210>  25
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Synthetic or Engineered CH2 Scaffold Protein

<400>  25

Gly Pro Ser Cys Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
1               5                   10                  15      


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Arg Thr Leu 
            20                  25                  30          


Arg Val Ser Gly Asp Tyr Val Arg Asp Phe Asp Leu Phe Asn Trp Tyr 
        35                  40                  45              


Val Asn Gly Ala Glu Val His His Ala Gln Thr Lys Pro Arg Glu Thr 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Thr His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Thr Cys Lys Val Gly Phe Ser 
                85                  90                  95      


Leu Ser Thr Ser Gly Met Cys Gln Lys Thr Ile Ser Lys Asp Lys Gly 
            100                 105                 110         


Ser His His His His His His 
        115                 


<210>  26
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Synthetic or Engineered CH2 Scaffold Protein

<400>  26

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Cys Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser Gln Glu Asp Pro Asp Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asn Gly Ala Glu Val His His Ala Gln Thr Lys Pro Arg Glu Thr 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Thr His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Thr Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Gln Cys Thr Ile Ser Lys Asp Lys His His 
            100                 105                 110         


His His His His 
        115     


<210>  27
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide Encoding CH2 Scaffold Protein

<400>  27
atggccgcac cagaattact cggcggccca agcgtatttc tcttcccacc aaaacctaaa       60

gacaccctga tgatcagccg caccccggag gtgacctgtg ttgtcgtcga tgtcagccac      120

gaggacccag aagtgaagtt caattggtat gtcgatggcg ttgaagttca taacgccaag      180

accaaaccgc gtgaagagca atacaatagc acctaccgtg tggtgagcgt gctgacggtc      240

ctgcaccagg actggctgaa cggtaaagag tacaagtgta aagtttccaa caaagcactg      300

ccggcaccga tcgaaaagac gattagcaaa gcgaagggca gccatcacca ccaccatcac      360

ggcagcggtt ctagt                                                       375


<210>  28
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide Encoding CH2 Scaffold Protein

<400>  28
atggccgcac cagaattact cggcggccca agcgtatttc tcttcccacc aaaacctaaa       60

gacaccctga tgatcagccg caccccggag gtgacctgtg ttgtcgtcga tgtcagccag      120

gaggacccag atgtgaagtt caattggtat gtcaacggcg cggaagttca tcacgcccag      180

accaaaccgc gtgaaaccca atacaatagc acctaccgtg tggtgagcgt gctgacggtc      240

acgcaccagg actggctgaa cggtaaagag tacacctgta aagtttccaa caaagcactg      300

ccggcaccga tccagaagac gattagcaaa gataagggca gccatcacca ccaccatcac      360

ggcagcggtt ctagt                                                       375


<210>  29
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide Encoding CH2 Scaffold Protein

<400>  29
atggccagcg gcccaagcgt attttgcttc ccaccaaaac ctaaagacac cctgatgatc       60

agccgcaccc cggaggtgac ctgtgttgtc gtcgatgtca gccaggagga cccagatgtg      120

aagttcaatt ggtatgtcaa cggcgcggaa gttcatcacg cccagaccaa accgcgtgaa      180

acccaataca atagcaccta ccgtgtggtg agcgtgctga cggtcacgca ccaggactgg      240

ctgaacggta aagagtacac ctgtaaagtt tccaacaaag cactgccggc accgatccag      300

tgcacgatta gcaaagataa gggcagccat caccaccacc atcacggcag cggttctagt      360


<210>  30
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide Encoding CH2 Scaffold Protein

<400>  30
atggccgcac cagaattact cggcggccca agcgtatttc tcttcccacc aaaacctaaa       60

gacaccctga tgatcagccg caccccggag gtgacctgtg ttgtcgtcga tgtcagccag      120

gaggacccag atgtgaagtt caattggtat gtcgatggcg cggaagttca tcacgcccag      180

accaaaccgc gtgaaaccca atacaatagc acctaccgtg tggtgagcgt gctgacggtc      240

ctgcaccagg actggctgaa cggtaaagag tacaagtgta aagtttccaa caaagcactg      300

ccggcaccga tcgaaaagac gattagcaaa gcgaagggca gccatcacca ccaccatcac      360

ggcagcggtt ctagt                                                       375


<210>  31
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide Encoding CH2 Scaffold Protein

<400>  31
atggccgcac cagaattact cggcggccca agcgtatttc tcttcccacc aaaacctaaa       60

gacaccctga tgatcagccg caccccggag gtgacctgtg ttgtcgtcga tgtcagccag      120

gaggacccag atgtgaagtt caattggtat gtcgatggcg cggaagttca tcacgcccag      180

accaaaccgc gtgaaaccca atacaatagc acctaccgtg tggtgagcgt gctgacggtc      240

ctgcaccagg actggctgaa cggtaaagag tacaagtgta aagtttccaa caaagcactg      300

ccggcaccga tcgaaaagac gattagcaaa gataagggca gccatcacca ccaccatcac      360

ggcagcggtt ctagt                                                       375


<210>  32
<211>  374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide Encoding CH2 Scaffold Protein

<400>  32
atggccgcac cagaattact cggcggccca agcgtatttc tcttcccacc aaaacctaaa       60

gacaccctga tgatcagccg caccccggag gtgacctgtg ttgtcgtcgg ctatagcatt      120

accagcgatt ttgcgttcaa ttggtatgtc gatggcgcgg aagttcatca cgcccagacc      180

aaaccgcgta tttattggga tacgataaaa cctaccgtgt ggtgagcgtg ctgacggtcc      240

tgcaccagga ctggctgaac ggtaaagagt acaagtgtaa agttgcgacc gcgggccgtg      300

gttttccgta tgaaaagacg attagcaaag cgaagggcag ccatcaccac caccatcacg      360

gcagcggttc tagt                                                        374


<210>  33
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide Encoding CH2 Scaffold Protein

<400>  33
atggccgcac cagaattact cggcggccca agcgtatttc tcttcccacc aaaacctaaa       60

gacaccctga tgatcagccg caccccggag gtgacctgtg ttgtcgtcgc gcgtaccctg      120

cgcgtgagcg gcgattatgt gcgtgatttc gatctgttca attggtatgt cgatggcgcg      180

gaagttcatc acgcccagac caaaccgcgt atttattggg atgacgataa aacctaccgt      240

gtggtgagcg tgctgacggt cctgcaccag gactggctga acggtaaaga gtacaagtgt      300

aaagttggct ttagcctgag cacctctggc atgagcgaaa agacgattag caaagcgaag      360

ggcagccatc accaccacca tcacggcagc ggttctagt                             399


<210>  34
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide Encoding CH2 Scaffold Protein

<400>  34
atggccagcg gcccaagcgt attttgcttc ccaccaaaac ctaaagacac cctgatgatc       60

agccgcaccc cggaggtgac ctgtgttgtc gtcgatgtca gccaggagga cccagatgtg      120

aagttcaatt ggtatgtcga tggcgcggaa gttcatcacg cccagaccaa accgcgtgaa      180

acccaataca atagcaccta ccgtgtggtg agcgtgctga cggtcctgca ccaggactgg      240

ctgaacggta aagagtacaa gtgtaaagtt tccaacaaag cactgccggc accgatcgaa      300

tgcacgatta gcaaagcgaa gggcagccat caccaccacc atcacggcag cggttctagt      360


<210>  35
<211>  374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide Encoding CH2 Scaffold Protein

<400>  35
atggccgcac cagaattact cggcggccca agctgctttc tcttcccacc aaaacctaaa       60

gacaccctga tgatcagccg caccccggag gtgacctgtg ttgtcgtcgg ctatagcatt      120

accagcgatt ttgcgttcaa ttggtatgtc gatggcgcgg aattcatcac gcccagacca      180

aaccgcgtat ttattgggat gacgataaaa cctaccgtgt ggtgagcgtg ctgacggtcc      240

tgcaccagga ctggctgaac ggtaaagagt acaagtgtaa agttgcgacc gcgggccgtg      300

gttttccgtg cgaaaagacg attagcaaag cgaagggcag ccatcaccac caccatcacg      360

gcagcggttc tagt                                                        374


<210>  36
<211>  396
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide Encoding CH2 Scaffold Protein

<400>  36
atggccgcac cagaattact cggcggccca agcgtatttc tcttcccacc aaaacctaaa       60

gacaccctga tgatcagccg caccccggag gtgacctgtg ttgtcgtcag cagcaacatt      120

ggtgcgggct atgatttcaa ttggtatgtc gatggcgcgg aagttcatca cgcccagacc      180

aaaccgcgta tttattggga tgacgataaa acctaccgtg tggtgagcgt gctgacggtc      240

ctgcaccagg actggctgaa cggtaaagag tacaagtgta aagttcagag ctatgatagc      300

agcctgagcg gcagcgtgga aaagacgatt agcaaagcga agggcagcca tcaccaccac      360

catcacggca gcggttctag tgcggccgca acttaa                                396


<210>  37
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Synthetic or Engineered CH2 Scaffold Protein

<400>  37

His His His His His His Gly Ser Gly Ser Cys Asp Lys Thr His Thr 
1               5                   10                  15      


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asn Gly Ala Glu Val His His Ala Gln Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Thr His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Thr Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Asp Lys 
        115                 120                 125     


