
                                SEQUENCE LISTING

<110> GENENTECH, INC. ET AL.

<120> COMPOSITIONS AND METHODS FOR USING CSF1R
  INHIBITORS

<130> P4836R1-WO

<140>     
<141> 2013-02-06

<150> US 61/680,674
<151>2012-08-07

<150> US 61/595,658       
<151> 2012-02-06  

<160> 87

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 242
<212> PRT
<213> Homo sapiens

<400> 1
Met Pro Arg Gly Phe Thr Trp Leu Arg Tyr Leu Gly Ile Phe Leu Gly
 1               5                  10                  15      
Val Ala Leu Gly Asn Glu Pro Leu Glu Met Trp Pro Leu Thr Gln Asn
            20                  25                  30          
Glu Glu Cys Thr Val Thr Gly Phe Leu Arg Asp Lys Leu Gln Tyr Arg
        35                  40                  45              
Ser Arg Leu Gln Tyr Met Lys His Tyr Phe Pro Ile Asn Tyr Lys Ile
    50                  55                  60                  
Ser Val Pro Tyr Glu Gly Val Phe Arg Ile Ala Asn Val Thr Arg Leu
65                  70                  75                  80  
Gln Arg Ala Gln Val Ser Glu Arg Glu Leu Arg Tyr Leu Trp Val Leu
                85                  90                  95      
Val Ser Leu Ser Ala Thr Glu Ser Val Gln Asp Val Leu Leu Glu Gly
            100                 105                 110         
His Pro Ser Trp Lys Tyr Leu Gln Glu Val Glu Thr Leu Leu Leu Asn
        115                 120                 125             
Val Gln Gln Gly Leu Thr Asp Val Glu Val Ser Pro Lys Val Glu Ser
    130                 135                 140                 
Val Leu Ser Leu Leu Asn Ala Pro Gly Pro Asn Leu Lys Leu Val Arg
145                 150                 155                 160 
Pro Lys Ala Leu Leu Asp Asn Cys Phe Arg Val Met Glu Leu Leu Tyr
                165                 170                 175     
Cys Ser Cys Cys Lys Gln Ser Ser Val Leu Asn Trp Gln Asp Cys Glu
            180                 185                 190         
Val Pro Ser Pro Gln Ser Cys Ser Pro Glu Pro Ser Leu Gln Tyr Ala
        195                 200                 205             
Ala Thr Gln Leu Tyr Pro Pro Pro Pro Trp Ser Pro Ser Ser Pro Pro
    210                 215                 220                 
His Ser Thr Gly Ser Val Arg Pro Val Arg Ala Gln Gly Glu Gly Leu
225                 230                 235                 240 
Leu Pro
        


<210> 2
<211> 972
<212> PRT
<213> Homo sapiens

<400> 2
Met Gly Pro Gly Val Leu Leu Leu Leu Leu Val Ala Thr Ala Trp His
 1               5                  10                  15      
Gly Gln Gly Ile Pro Val Ile Glu Pro Ser Val Pro Glu Leu Val Val
            20                  25                  30          
Lys Pro Gly Ala Thr Val Thr Leu Arg Cys Val Gly Asn Gly Ser Val
        35                  40                  45              
Glu Trp Asp Gly Pro Pro Ser Pro His Trp Thr Leu Tyr Ser Asp Gly
    50                  55                  60                  
Ser Ser Ser Ile Leu Ser Thr Asn Asn Ala Thr Phe Gln Asn Thr Gly
65                  70                  75                  80  
Thr Tyr Arg Cys Thr Glu Pro Gly Asp Pro Leu Gly Gly Ser Ala Ala
                85                  90                  95      
Ile His Leu Tyr Val Lys Asp Pro Ala Arg Pro Trp Asn Val Leu Ala
            100                 105                 110         
Gln Glu Val Val Val Phe Glu Asp Gln Asp Ala Leu Leu Pro Cys Leu
        115                 120                 125             
Leu Thr Asp Pro Val Leu Glu Ala Gly Val Ser Leu Val Arg Val Arg
    130                 135                 140                 
Gly Arg Pro Leu Met Arg His Thr Asn Tyr Ser Phe Ser Pro Trp His
145                 150                 155                 160 
Gly Phe Thr Ile His Arg Ala Lys Phe Ile Gln Ser Gln Asp Tyr Gln
                165                 170                 175     
Cys Ser Ala Leu Met Gly Gly Arg Lys Val Met Ser Ile Ser Ile Arg
            180                 185                 190         
Leu Lys Val Gln Lys Val Ile Pro Gly Pro Pro Ala Leu Thr Leu Val
        195                 200                 205             
Pro Ala Glu Leu Val Arg Ile Arg Gly Glu Ala Ala Gln Ile Val Cys
    210                 215                 220                 
Ser Ala Ser Ser Val Asp Val Asn Phe Asp Val Phe Leu Gln His Asn
225                 230                 235                 240 
Asn Thr Lys Leu Ala Ile Pro Gln Gln Ser Asp Phe His Asn Asn Arg
                245                 250                 255     
Tyr Gln Lys Val Leu Thr Leu Asn Leu Asp Gln Val Asp Phe Gln His
            260                 265                 270         
Ala Gly Asn Tyr Ser Cys Val Ala Ser Asn Val Gln Gly Lys His Ser
        275                 280                 285             
Thr Ser Met Phe Phe Arg Val Val Glu Ser Ala Tyr Leu Asn Leu Ser
    290                 295                 300                 
Ser Glu Gln Asn Leu Ile Gln Glu Val Thr Val Gly Glu Gly Leu Asn
305                 310                 315                 320 
Leu Lys Val Met Val Glu Ala Tyr Pro Gly Leu Gln Gly Phe Asn Trp
                325                 330                 335     
Thr Tyr Leu Gly Pro Phe Ser Asp His Gln Pro Glu Pro Lys Leu Ala
            340                 345                 350         
Asn Ala Thr Thr Lys Asp Thr Tyr Arg His Thr Phe Thr Leu Ser Leu
        355                 360                 365             
Pro Arg Leu Lys Pro Ser Glu Ala Gly Arg Tyr Ser Phe Leu Ala Arg
    370                 375                 380                 
Asn Pro Gly Gly Trp Arg Ala Leu Thr Phe Glu Leu Thr Leu Arg Tyr
385                 390                 395                 400 
Pro Pro Glu Val Ser Val Ile Trp Thr Phe Ile Asn Gly Ser Gly Thr
                405                 410                 415     
Leu Leu Cys Ala Ala Ser Gly Tyr Pro Gln Pro Asn Val Thr Trp Leu
            420                 425                 430         
Gln Cys Ser Gly His Thr Asp Arg Cys Asp Glu Ala Gln Val Leu Gln
        435                 440                 445             
Val Trp Asp Asp Pro Tyr Pro Glu Val Leu Ser Gln Glu Pro Phe His
    450                 455                 460                 
Lys Val Thr Val Gln Ser Leu Leu Thr Val Glu Thr Leu Glu His Asn
465                 470                 475                 480 
Gln Thr Tyr Glu Cys Arg Ala His Asn Ser Val Gly Ser Gly Ser Trp
                485                 490                 495     
Ala Phe Ile Pro Ile Ser Ala Gly Ala His Thr His Pro Pro Asp Glu
            500                 505                 510         
Phe Leu Phe Thr Pro Val Val Val Ala Cys Met Ser Ile Met Ala Leu
        515                 520                 525             
Leu Leu Leu Leu Leu Leu Leu Leu Leu Tyr Lys Tyr Lys Gln Lys Pro
    530                 535                 540                 
Lys Tyr Gln Val Arg Trp Lys Ile Ile Glu Ser Tyr Glu Gly Asn Ser
545                 550                 555                 560 
Tyr Thr Phe Ile Asp Pro Thr Gln Leu Pro Tyr Asn Glu Lys Trp Glu
                565                 570                 575     
Phe Pro Arg Asn Asn Leu Gln Phe Gly Lys Thr Leu Gly Ala Gly Ala
            580                 585                 590         
Phe Gly Lys Val Val Glu Ala Thr Ala Phe Gly Leu Gly Lys Glu Asp
        595                 600                 605             
Ala Val Leu Lys Val Ala Val Lys Met Leu Lys Ser Thr Ala His Ala
    610                 615                 620                 
Asp Glu Lys Glu Ala Leu Met Ser Glu Leu Lys Ile Met Ser His Leu
625                 630                 635                 640 
Gly Gln His Glu Asn Ile Val Asn Leu Leu Gly Ala Cys Thr His Gly
                645                 650                 655     
Gly Pro Val Leu Val Ile Thr Glu Tyr Cys Cys Tyr Gly Asp Leu Leu
            660                 665                 670         
Asn Phe Leu Arg Arg Lys Ala Glu Ala Met Leu Gly Pro Ser Leu Ser
        675                 680                 685             
Pro Gly Gln Asp Pro Glu Gly Gly Val Asp Tyr Lys Asn Ile His Leu
    690                 695                 700                 
Glu Lys Lys Tyr Val Arg Arg Asp Ser Gly Phe Ser Ser Gln Gly Val
705                 710                 715                 720 
Asp Thr Tyr Val Glu Met Arg Pro Val Ser Thr Ser Ser Asn Asp Ser
                725                 730                 735     
Phe Ser Glu Gln Asp Leu Asp Lys Glu Asp Gly Arg Pro Leu Glu Leu
            740                 745                 750         
Arg Asp Leu Leu His Phe Ser Ser Gln Val Ala Gln Gly Met Ala Phe
        755                 760                 765             
Leu Ala Ser Lys Asn Cys Ile His Arg Asp Val Ala Ala Arg Asn Val
    770                 775                 780                 
Leu Leu Thr Asn Gly His Val Ala Lys Ile Gly Asp Phe Gly Leu Ala
785                 790                 795                 800 
Arg Asp Ile Met Asn Asp Ser Asn Tyr Ile Val Lys Gly Asn Ala Arg
                805                 810                 815     
Leu Pro Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asp Cys Val Tyr
            820                 825                 830         
Thr Val Gln Ser Asp Val Trp Ser Tyr Gly Ile Leu Leu Trp Glu Ile
        835                 840                 845             
Phe Ser Leu Gly Leu Asn Pro Tyr Pro Gly Ile Leu Val Asn Ser Lys
    850                 855                 860                 
Phe Tyr Lys Leu Val Lys Asp Gly Tyr Gln Met Ala Gln Pro Ala Phe
865                 870                 875                 880 
Ala Pro Lys Asn Ile Tyr Ser Ile Met Gln Ala Cys Trp Ala Leu Glu
                885                 890                 895     
Pro Thr His Arg Pro Thr Phe Gln Gln Ile Cys Ser Phe Leu Gln Glu
            900                 905                 910         
Gln Ala Gln Glu Asp Arg Arg Glu Arg Asp Tyr Thr Asn Leu Pro Ser
        915                 920                 925             
Ser Ser Arg Ser Gly Gly Ser Gly Ser Ser Ser Ser Glu Leu Glu Glu
    930                 935                 940                 
Glu Ser Ser Ser Glu His Leu Thr Cys Cys Glu Gln Gly Asp Ile Ala
945                 950                 955                 960 
Gln Pro Leu Leu Gln Pro Asn Asn Tyr Gln Phe Cys
                965                 970         


<210> 3
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 3
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Thr
            20                  25                  30          
Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Arg Ile Ser Pro Tyr Tyr Tyr Tyr Ser Asp Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Leu Gly Lys Gly Ser Lys Arg Gly Ala Met Asp Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 4
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 4
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Phe Tyr Phe Pro Asn
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105             


<210> 5
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 5
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Thr
            20                  25                  30          
Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Arg Ile Ser Pro Tyr Ser Gly Tyr Thr Asn Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Leu Gly Lys Gly Ser Lys Arg Gly Ala Met Asp Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 6
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 6
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Thr Pro Pro
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105             


<210> 7
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 7
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Thr
            20                  25                  30          
Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Arg Ile Ser Pro Tyr Ser Gly Tyr Thr Asn Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Leu Gly Lys Gly Ser Lys Arg Gly Ala Met Asp Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 8
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 8
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Thr Ala Leu Pro Tyr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105             


<210> 9
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 9
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Thr
            20                  25                  30          
Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Arg Ile Ser Pro Tyr Ser Gly Tyr Thr Asn Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Leu Gly Lys Gly Ser Lys Arg Gly Ala Met Asp Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 10
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 10
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asp Val Pro Tyr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105             


<210> 11
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 11
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Thr
            20                  25                  30          
Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Arg Ile Ser Pro Tyr Ser Gly Tyr Thr Asn Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Leu Gly Lys Gly Ser Lys Arg Gly Ala Met Asp Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 12
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 12
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asp Leu Pro Tyr
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105             


<210> 13
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 13
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Thr
            20                  25                  30          
Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Arg Ile Ser Pro Tyr Ser Gly Tyr Thr Asn Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Ile Asn Gln Gly Ser Lys Arg Gly Ala Met Asp Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 14
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 14
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Thr Ala Arg Pro
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105             


<210> 15
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 15
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Asn
            20                  25                  30          
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Ser Ile Thr Pro Ala Ser Gly Asp Thr Asp Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Arg Gly Ala Tyr Arg Phe Ala Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser
        115             


<210> 16
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 16
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Thr Pro Pro
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105             


<210> 17
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 17
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser
            20                  25  


<210> 18
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 18
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
 1               5                  10              


<210> 19
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 19
Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln
 1               5                  10                  15      
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg
            20                  25                  30          


<210> 20
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 20
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
 1               5                  10      


<210> 21
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 21
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys
            20              


<210> 22
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 22
Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
 1               5                  10                  15  


<210> 23
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 23
Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
 1               5                  10                  15      
Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys
            20                  25                  30          


<210> 24
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 24
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
 1               5                  10          


<210> 25
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 25
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Thr Ser Tyr
            20                  25                  30          
Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser His Ile Asp Trp Tyr Gly Gly Asp Thr Asp Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Gly Pro Asp Tyr Ala Met Asp Val Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser
        115             


<210> 26
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 26
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Ser Ser Arg Ala Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Glu Pro Val
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105             


<210> 27
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 27
Ala Arg Gly Ile Asn Gln Gly Ser Lys Arg Gly Ala Met Asp
 1               5                  10                     


<210> 28
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 28
Ala Arg Gly Leu Gly Lys Gly Ser Lys Arg Gly Ala Met Asp
 1               5                  10                  


<210> 29
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 29
Ala Arg Ser Arg Gly Ala Tyr Arg Phe Ala
 1               5                  10  


<210> 30
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 30
Gly Phe Thr Phe Ser Ser Thr
 1               5          


<210> 31
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 31
Gly Phe Thr Phe Thr Ser Asn
 1               5          


<210> 32
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 32
Gly Ile Asn Gln Gly Ser Lys Arg Gly Ala Met Asp Tyr
 1               5                  10              


<210> 33
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 33
Gly Leu Gly Lys Gly Ser Lys Arg Gly Ala Met Asp Tyr
 1               5                  10              


<210> 34
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 34
Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr
 1               5                  10  


<210> 35
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 35
Pro Ala Ser Gly Asp
 1               5  


<210> 36
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 36
Pro Tyr Ser Gly Tyr
 1               5  


<210> 37
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 37
Pro Tyr Tyr Tyr Tyr
 1               5  


<210> 38
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 38
Gln Gln Ser Phe Tyr Phe Pro Asn
 1               5              


<210> 39
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 39
Gln Gln Ser Phe Tyr Phe Pro Asn Thr
 1               5                  


<210> 40
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 40
Gln Gln Ser Arg Thr Ala Arg Pro
 1               5              


<210> 41
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 41
Gln Gln Ser Arg Thr Ala Arg Pro Thr
 1               5                  


<210> 42
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 42
Gln Gln Ser Tyr Thr Thr Pro Pro
 1               5              


<210> 43
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 43
Gln Gln Ser Tyr Thr Thr Pro Pro Thr
 1               5                  


<210> 44
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 44
Gln Gln Tyr Ser Asp Leu Pro Tyr
 1               5              


<210> 45
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 45
Gln Gln Tyr Ser Asp Leu Pro Tyr Thr
 1               5                  


<210> 46
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 46
Gln Gln Tyr Ser Asp Val Pro Tyr
 1               5              


<210> 47
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 47
Gln Gln Tyr Ser Asp Val Pro Tyr Thr
 1               5                  


<210> 48
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 48
Gln Gln Tyr Thr Ala Leu Pro Tyr
 1               5              


<210> 49
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 49
Gln Gln Tyr Thr Ala Leu Pro Tyr Thr
 1               5                  


<210> 50
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 50
Arg Ala Ser Gln Asp Val Ser Thr Ala Val Ala
 1               5                  10      


<210> 51
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 51
Arg Ile Ser Pro Tyr Ser Gly Tyr Thr Asn Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 52
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 52
Arg Ile Ser Pro Tyr Tyr Tyr Tyr Ser Asp Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 53
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 53
Ser Ala Ser Phe Leu Tyr Ser
 1               5          


<210> 54
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 54
Ser Ile Thr Pro Ala Ser Gly Asp Thr Asp Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 55
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 55
Ser Asn Tyr Ile His
 1               5  


<210> 56
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 56
Ser Arg Gly Ala Tyr Arg Phe Ala Tyr
 1               5                  


<210> 57
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 57
Ser Ser Thr Trp Ile His
 1               5      


<210> 58
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 58
Ser Thr Ala Val Ala Trp Tyr
 1               5          


<210> 59
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 59
Ser Thr Trp Ile His
 1               5  


<210> 60
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 60
Thr Ser Asn Tyr Ile His
 1               5      


<210> 61
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 61
Trp Val Ala Arg Ile Ser Pro Tyr Ser Gly Tyr Thr Asn
 1               5                  10              


<210> 62
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 62
Trp Val Ala Arg Ile Ser Pro Tyr Tyr Tyr Tyr Ser Asp
 1               5                  10              


<210> 63
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 63
Trp Val Ala Ser Ile Thr Pro Ala Ser Gly Asp Thr Asp
 1               5                  10              


<210> 64
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<221> VARIANT        
<222> 2
<223> Xaa = Asn or Thr

<221> VARIANT        
<222> 3
<223> Xaa = Tyr or Trp

<400> 64
Ser Xaa Xaa Ile His
 1               5  


<210> 65
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<221> VARIANT        
<222> 1
<223> Xaa = Ser or Arg

<221> VARIANT        
<222> 3
<223> Xaa = Thr or Ser

<221> VARIANT        
<222> 5
<223> Xaa = Ala or Tyr

<221> VARIANT        
<222> 6
<223> Xaa = Ser or Tyr

<221> VARIANT        
<222> 7
<223> Xaa = Gly or Tyr

<221> VARIANT        
<222> 8
<223> Xaa = Asp or Tyr

<221> VARIANT        
<222> 9
<223> Xaa = Thr or Ser

<221> VARIANT        
<222> 10
<223> Xaa = Asp or Asn

<400> 65
Xaa Ile Xaa Pro Xaa Xaa Xaa Xaa Xaa Xaa Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 66
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<221> VARIANT        
<222> 2
<223> Xaa = Leu or Ile

<221> VARIANT        
<222> 3
<223> Xaa = Gly or Asn

<221> VARIANT        
<222> 4
<223> Xaa = Lys or Gln

<400> 66
Gly Xaa Xaa Xaa Gly Ser Lys Arg Gly Ala Met Asp Tyr
 1               5                  10              


<210> 67
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<221> VARIANT        
<222> 3
<223> Xaa = Ser or Tyr

<221> VARIANT        
<222> 5
<223> Xaa = Tyr, Thr, Ser, Phe, or Arg

<221> VARIANT        
<222> 7
<223> Xaa = Thr, Ala, Asp, or Tyr

<221> VARIANT        
<222> 8
<223> Xaa = Thr, Leu, Val, Phe, or Ala

<221> VARIANT        
<222> 9
<223> Xaa = Pro or Arg

<221> VARIANT        
<222> 10
<223> Xaa = Pro, Tyr, or Asn

<400> 67
Gln Gln Xaa Ile Xaa Pro Xaa Xaa Xaa Xaa Thr
 1               5                  10      


<210> 68
<211> 173
<212> PRT
<213> Homo sapiens

<400> 68
Asn Glu Pro Leu Glu Met Trp Pro Leu Thr Gln Asn Glu Glu Cys Thr
 1               5                  10                  15      
Val Thr Gly Phe Leu Arg Asp Lys Leu Gln Tyr Arg Ser Arg Leu Gln
            20                  25                  30          
Tyr Met Lys His Tyr Phe Pro Ile Asn Tyr Lys Ile Ser Val Pro Tyr
        35                  40                  45              
Glu Gly Val Phe Arg Ile Ala Asn Val Thr Arg Leu Gln Arg Ala Gln
    50                  55                  60                  
Val Ser Glu Arg Glu Leu Arg Tyr Leu Trp Val Leu Val Ser Leu Ser
65                  70                  75                  80  
Ala Thr Glu Ser Val Gln Asp Val Leu Leu Glu Gly His Pro Ser Trp
                85                  90                  95      
Lys Tyr Leu Gln Glu Val Glu Thr Leu Leu Leu Asn Val Gln Gln Gly
            100                 105                 110         
Leu Thr Asp Val Glu Val Ser Pro Lys Val Glu Ser Val Leu Ser Leu
        115                 120                 125             
Leu Asn Ala Pro Gly Pro Asn Leu Lys Leu Val Arg Pro Lys Ala Leu
    130                 135                 140                 
Leu Asp Asn Cys Phe Arg Val Met Glu Leu Leu Tyr Cys Ser Cys Cys
145                 150                 155                 160 
Lys Gln Ser Ser Val Leu Asn Trp Gln Asp Cys Glu Val
                165                 170             


<210> 69
<211> 173
<212> PRT
<213> Macaca mulatta

<400> 69
Asn Glu His Leu Glu Ile Trp Pro Leu Thr Gln Ser Glu Glu Cys Thr
 1               5                  10                  15      
Val Thr Gly Phe Leu Arg Asp Lys Leu Gln Tyr Arg Asn Arg Leu Gln
            20                  25                  30          
Tyr Met Lys His Tyr Phe Pro Ile Asn Tyr Lys Ile Ser Val Pro Tyr
        35                  40                  45              
Glu Gly Val Phe Arg Ile Ala Asn Val Thr Arg Leu Gln Arg Ala Arg
    50                  55                  60                  
Val Ser Glu Arg Glu Leu Arg Tyr Leu Trp Val Leu Val Ser Leu Ser
65                  70                  75                  80  
Ala Thr Glu Ser Val Gln Asp Val Leu Leu Asp Gly His Pro Ser Trp
                85                  90                  95      
Lys Tyr Leu Gln Glu Val Gln Thr Leu Leu Leu Asn Val Gln Lys Gly
            100                 105                 110         
Leu Met Asp Val Glu Val Ser Pro Lys Val Glu Ser Val Leu Ser Leu
        115                 120                 125             
Leu Asn Ala Pro Gly Pro Asn Leu Lys Pro Val Arg Pro Lys Ala Leu
    130                 135                 140                 
Leu Asp Asn Cys Phe Arg Val Met Glu Leu Leu Tyr Cys Ser Cys Cys
145                 150                 155                 160 
Lys Gln Ser Ser Val Leu Asn Trp Gln Asp Cys Glu Val
                165                 170             


<210> 70
<211> 173
<212> PRT
<213> Canis lupus familiaris

<400> 70
Asn Gln Gly Leu Glu Met Trp Pro Leu Thr Gln Asn Glu Glu Cys Ala
 1               5                  10                  15      
Val Thr Gly Phe Leu Arg Asp Lys Leu Gln Tyr Arg Asn Arg Leu Gln
            20                  25                  30          
Tyr Met Lys His Tyr Phe Pro Ile Asn Tyr Arg Val Ser Val Pro Tyr
        35                  40                  45              
Glu Gly Val Leu Arg Met Ala Asn Ile Thr Arg Leu Gln Arg Ala Arg
    50                  55                  60                  
Val Ser Gln Gln Glu Leu Arg Tyr Leu Trp Val Trp Val Ser Leu Ser
65                  70                  75                  80  
Ala Thr Glu Ser Val Gln Glu Val Leu Leu Glu Gly His Pro Ser Trp
                85                  90                  95      
Lys Tyr Leu Glu Asp Val His Thr Leu Leu Leu Asp Val Gln Gln Ser
            100                 105                 110         
Leu Thr Asp Val Glu Val Gly Pro Lys Val Glu Ala Val Val Ser Leu
        115                 120                 125             
Leu Ser Ala Pro Arg Leu Ser Leu Lys Leu Val Arg Pro Lys Ala Leu
    130                 135                 140                 
Leu Asp Asn Cys Phe Arg Val Met Glu Leu Leu Tyr Cys Ser Cys Cys
145                 150                 155                 160 
Lys Gln Ser Ser Val Leu Asn Trp Gln Asp Cys Glu Val
                165                 170             


<210> 71
<211> 173
<212> PRT
<213> Ailuropoda melanoleuca

<400> 71
Asn Glu Gly Leu Glu Met Trp Pro Leu Thr Gln Thr Glu Glu Cys Ala
 1               5                  10                  15      
Ile Thr Gly Phe Leu Arg Asp Lys Leu Gln Tyr Arg Asn Arg Leu Gln
            20                  25                  30          
Tyr Met Lys His Tyr Phe Pro Ile Asn Tyr Arg Val Gly Val Pro Tyr
        35                  40                  45              
Glu Gly Val Leu Arg Met Ala Asn Ile Thr Arg Leu Gln Arg Ala Arg
    50                  55                  60                  
Val Ser Gln Gln Glu Leu Arg Tyr Leu Trp Val Trp Val Ser Leu Ser
65                  70                  75                  80  
Ala Thr Glu Ser Val Gln Glu Val Leu Leu Glu Gly His Pro Ser Trp
                85                  90                  95      
Lys Tyr Leu Lys Glu Val His Thr Leu Leu Leu Asp Val Gln Gln Ser
            100                 105                 110         
Leu Arg Asp Val Glu Val Ser Pro Lys Val Asp Ala Thr Val Ser Leu
        115                 120                 125             
Leu Ser Ala Pro Arg Leu Ser Leu Lys Leu Val Arg Pro Lys Ala Leu
    130                 135                 140                 
Leu Asp Asn Cys Phe Arg Val Met Glu Leu Leu Tyr Cys Ser Cys Cys
145                 150                 155                 160 
Lys Gln Ser Ser Val Leu Asn Trp Gln Asp Cys Glu Leu
                165                 170             


<210> 72
<211> 173
<212> PRT
<213> Equus caballus

<400> 72
Asn Lys Gly Leu Glu Val Trp Pro Leu Thr Gln Ser Glu Glu Cys Ala
 1               5                  10                  15      
Val Thr Gly Phe Leu Arg Asp Lys Leu Gln Tyr Arg Asn Arg Leu Gln
            20                  25                  30          
Tyr Met Lys His Tyr Phe Pro Ile Asn Tyr Arg Val Ser Val Pro Tyr
        35                  40                  45              
Glu Gly Val Leu Arg Met Ala Asn Val Thr Arg Leu Gln Arg Ala Arg
    50                  55                  60                  
Val Ser Gln Gln Glu Leu Arg Tyr Leu Trp Val Trp Val Ser Leu Ser
65                  70                  75                  80  
Ala Thr Glu Trp Val Gln Glu Val Leu Leu Glu Asp His Pro Ser Trp
                85                  90                  95      
Lys Tyr Leu Glu Glu Val His Thr Leu Leu Leu Asp Val Gln Gln Ser
            100                 105                 110         
Leu Arg Asp Val Glu Val Ser Pro Gln Val Glu Ala Val Leu Ser Leu
        115                 120                 125             
Leu Ser Ala Pro Gly Leu Ser Leu Lys Leu Val Arg Pro Lys Ala Leu
    130                 135                 140                 
Leu Asp Asn Cys Phe Arg Val Met Glu Leu Leu Tyr Cys Pro Cys Cys
145                 150                 155                 160 
Lys His Ser Ser Val Leu Asn Trp Gln Asp Cys Glu Leu
                165                 170             


<210> 73
<211> 172
<212> PRT
<213> Bos taurus

<400> 73
Asn Glu Gly Leu Glu Pro Trp Pro Leu Thr Arg Ser Asp Glu Cys Ala
 1               5                  10                  15      
Ile Thr Gly Phe Leu Arg Asp Lys Leu Gln Tyr Arg Asn Arg Leu Gln
            20                  25                  30          
Tyr Met Lys His Tyr Phe Pro Ile Asn Tyr Arg Val Ser Val Pro Tyr
        35                  40                  45              
Glu Gly Val Leu Arg Thr Ala Asn Val Thr Arg Leu Gln Arg Ala Gln
    50                  55                  60                  
Val Ser Gln Gln Glu Leu Arg Tyr Leu Trp Val Leu Val Ser Leu Ser
65                  70                  75                  80  
Ala Thr Glu Trp Val Gln Glu Val Leu Leu Glu Gly His Pro Ser Trp
                85                  90                  95      
Lys Tyr Leu Glu Glu Val His Thr Leu Leu Leu Asp Val Lys Gln Gly
            100                 105                 110         
Leu Gly Gly Val Glu Val Ser Pro Gln Val Glu Ala Val Leu Asn Leu
        115                 120                 125             
Leu Ser Ala Pro Gly Ser Leu Lys Leu Val Arg Pro Lys Ala Leu Leu
    130                 135                 140                 
Asp Asn Cys Phe Arg Val Met Gln Leu Leu Tyr Cys Pro Cys Cys Lys
145                 150                 155                 160 
Glu Ser Ser Val Leu Asn Trp Gln Asp Cys Glu Ala
                165                 170         


<210> 74
<211> 173
<212> PRT
<213> Mus musculus

<400> 74
Asn Glu Asn Leu Glu Ile Trp Thr Leu Thr Gln Asp Lys Glu Cys Asp
 1               5                  10                  15      
Leu Thr Gly Tyr Leu Arg Gly Lys Leu Gln Tyr Lys Asn Arg Leu Gln
            20                  25                  30          
Tyr Met Lys His Tyr Phe Pro Ile Asn Tyr Arg Ile Ala Val Pro Tyr
        35                  40                  45              
Glu Gly Val Leu Arg Val Ala Asn Ile Thr Arg Leu Gln Lys Ala His
    50                  55                  60                  
Val Ser Glu Arg Glu Leu Arg Tyr Leu Trp Val Leu Val Ser Leu Asn
65                  70                  75                  80  
Ala Thr Glu Ser Val Met Asp Val Leu Leu Glu Gly His Pro Ser Trp
                85                  90                  95      
Lys Tyr Leu Gln Glu Val Gln Thr Leu Leu Glu Asn Val Gln Arg Ser
            100                 105                 110         
Leu Met Asp Val Glu Ile Gly Pro His Val Glu Ala Val Leu Ser Leu
        115                 120                 125             
Leu Ser Thr Pro Gly Leu Ser Leu Lys Leu Val Arg Pro Lys Ala Leu
    130                 135                 140                 
Leu Asp Asn Cys Phe Arg Val Met Glu Leu Leu Tyr Cys Ser Cys Cys
145                 150                 155                 160 
Lys Gln Ser Pro Ile Leu Lys Trp Gln Asp Cys Glu Leu
                165                 170             


<210> 75
<211> 172
<212> PRT
<213> Rattus norvegicus

<400> 75
Asn Glu Asn Leu Glu Ile Trp Thr Leu Ala Gln Asp Lys Glu Cys Asp
 1               5                  10                  15      
Leu Thr Gly Tyr Leu Arg Gly Lys Leu Gln Tyr Lys Asn Arg Leu Gln
            20                  25                  30          
Tyr Met Lys His Tyr Phe Pro Ile Asn Tyr Arg Ile Ala Val Pro Tyr
        35                  40                  45              
Glu Gly Val Leu Arg Val Ala Asn Ile Thr Arg Leu Lys Ala His Val
    50                  55                  60                  
Ser Glu Arg Glu Leu Arg Tyr Leu Trp Val Leu Val Ser Leu Asn Ala
65                  70                  75                  80  
Thr Glu Ser Val Leu Asp Val Leu Leu Glu Gly His Pro Ser Trp Lys
                85                  90                  95      
Tyr Leu Gln Glu Val Gln Thr Leu Leu Glu Asn Val Gln Arg Ser Leu
            100                 105                 110         
Met Asp Val Glu Ile Gly Pro His Val Glu Ala Val Leu Ser Leu Leu
        115                 120                 125             
Ser Thr Pro Gly Leu Ser Leu Lys Leu Val Arg Pro Lys Ala Leu Leu
    130                 135                 140                 
Asp Asn Cys Phe Arg Val Met Glu Leu Leu Tyr Cys Ser Cys Cys Lys
145                 150                 155                 160 
Gln Ser Pro Ile Leu Lys Trp Gln Asp Cys Glu Leu
                165                 170         


<210> 76
<211> 173
<212> PRT
<213> Artificial Sequence

<220> 
<223> Consensus Sequence

<221> VARIANT        
<222> 3
<223> Xaa = Pro, His, Gly or Asn

<221> VARIANT        
<222> 6
<223> Xaa = Met, Ile, Val or Pro

<221> VARIANT        
<222> 12
<223> Xaa = Asn, Ser, Thr or Asp

<221> VARIANT        
<222> 16
<223> Xaa = Thr, Ala or Asp

<221> VARIANT        
<222> 20
<223> Xaa = Phe or Tyr

<221> VARIANT        
<222> 44
<223> Xaa = Ile or Val

<221> VARIANT        
<222> 45
<223> Xaa = Ser, Gly or Ala

<221> VARIANT        
<222> 54
<223> Xaa = Ile, Met, Thr or Val

<221> VARIANT        
<222> 57
<223> Xaa = Val or Ile

<221> VARIANT        
<222> 64
<223> Xaa = Gln, Arg or His

<221> VARIANT        
<222> 67
<223> Xaa = Glu or Gln

<221> VARIANT        
<222> 68
<223> Xaa = Arg or Gln

<221> VARIANT        
<222> 76
<223> Xaa = Leu or Trp

<221> VARIANT        
<222> 87
<223> Xaa = Asp or Glu

<221> VARIANT        
<222> 91
<223> Xaa = Asp or Glu

<221> VARIANT        
<222> 101
<223> Xaa = Asp or Glu

<221> VARIANT        
<222> 103
<223> Xaa = Glu, Gln or His

<221> VARIANT        
<222> 108
<223> Xaa = Asn or Asp

<221> VARIANT        
<222> 111
<223> Xaa = Gln, Lys or Arg

<221> VARIANT        
<222> 112
<223> Xaa = Gly or Ser

<221> VARIANT        
<222> 114
<223> Xaa = Thr, Met, Arg or Gly

<221> VARIANT        
<222> 118
<223> Xaa = Val or Ile

<221> VARIANT        
<222> 119
<223> Xaa = Ser or Gly

<221> VARIANT        
<222> 121
<223> Xaa = Lys, Gln or His

<221> VARIANT        
<222> 123
<223> Xaa = Glu or Asp

<221> VARIANT        
<222> 134
<223> Xaa = Pro or Leu

<221> VARIANT        
<222> 153
<223> Xaa = Glu or Gln

<221> VARIANT        
<222> 165
<223> Xaa = Val or Ile

<221> VARIANT        
<222> 173
<223> Xaa = Val, Leu or Ala

<400> 76
Asn Glu Xaa Leu Glu Xaa Trp Pro Leu Thr Gln Xaa Glu Glu Cys Xaa
 1               5                  10                  15      
Val Thr Gly Xaa Leu Arg Asp Lys Leu Gln Tyr Arg Asn Arg Leu Gln
            20                  25                  30          
Tyr Met Lys His Tyr Phe Pro Ile Asn Tyr Arg Xaa Xaa Val Pro Tyr
        35                  40                  45              
Glu Gly Val Leu Arg Xaa Ala Asn Xaa Thr Arg Leu Gln Arg Ala Xaa
    50                  55                  60                  
Val Ser Xaa Xaa Glu Leu Arg Tyr Leu Trp Val Xaa Val Ser Leu Ser
65                  70                  75                  80  
Ala Thr Glu Ser Val Gln Xaa Val Leu Leu Xaa Gly His Pro Ser Trp
                85                  90                  95      
Lys Tyr Leu Gln Xaa Val Xaa Thr Leu Leu Leu Xaa Val Gln Xaa Xaa
            100                 105                 110         
Leu Xaa Asp Val Glu Xaa Xaa Pro Xaa Val Xaa Ala Val Leu Ser Leu
        115                 120                 125             
Leu Ser Ala Pro Gly Xaa Ser Leu Lys Leu Val Arg Pro Lys Ala Leu
    130                 135                 140                 
Leu Asp Asn Cys Phe Arg Val Met Xaa Leu Leu Tyr Cys Ser Cys Cys
145                 150                 155                 160 
Lys Gln Ser Ser Xaa Leu Asn Trp Gln Asp Cys Glu Xaa
                165                 170             


<210> 77
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 77
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Asn
            20                  25                  30          
Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Arg Ile Ser Pro Asn Ser Gly Tyr Thr Asp Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Met Arg Ala Arg Arg Gly Phe Asp Tyr
            100                 105             


<210> 78
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 78
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Thr Pro Pro
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105             


<210> 79
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 79
Ser Asn Trp Ile His
 1               5  


<210> 80
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 80
Arg Ile Ser Pro Asn Ser Gly Tyr Thr Asp Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 81
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 81
Ser Met Arg Ala Arg Arg Gly Phe Asp Tyr
 1               5                  10  


<210> 82
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 82
Ser Tyr Gly Ile Ser
 1               5  


<210> 83
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 83
His Ile Asp Trp Tyr Gly Gly Asp Thr Asp Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 84
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 84
Gly Gly Pro Asp Tyr Ala Met Asp Val
 1               5                  


<210> 85
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 85
Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ala
 1               5                  10      


<210> 86
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 86
Gly Ala Ser Ser Arg Ala Ser
 1               5          


<210> 87
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 87
Gln Gln Tyr Trp Ser Glu Pro Val Thr
 1               5                      


