                         SEQUENCE LISTING

<110>  Queen Mary & Westfield College, University of London
 
<120>  REVERSAL OF SENESCENCE

<130>  P54020WO/TCL

<150>  GB 1202228.1
<151>  2012-02-08

<160>  206   

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  DNA
<213>  Homo sapiens


<220>
<223>  Short p16 siRNA target sequence (DNA)

<400>  1
taccgtaaat gtccatttat a                                                 21


<210>  2
<211>  21
<212>  RNA
<213>  Homo sapiens


<220>
<223>  Short p16 siRNA target sequence (RNA)

<400>  2
uaccguaaau guccauuuau a                                                 21


<210>  3
<211>  1163
<212>  DNA
<213>  Homo sapiens


<220>
<223>  NM_000077.3 [gi:47132606] Homo sapiens cyclin-dependent kinase 
       inhibitor 2A (melanoma, p16, inhibits CDK4) (CDKN2A), transcript 
       variant 1, (DNA)

<400>  3
ctcctccgag cactcgctca cggcgtcccc ttgcctggaa agataccgcg gtccctccag       60

aggatttgag ggacagggtc ggagggggct cttccgccag caccggagga agaaagagga      120

ggggctggct ggtcaccaga gggtggggcg gaccgcgtgc gctcggcggc tgcggagagg      180

gggagagcag gcagcgggcg gcggggagca gcatggagcc ggcggcgggg agcagcatgg      240

agccttcggc tgactggctg gccacggccg cggcccgggg tcgggtagag gaggtgcggg      300

cgctgctgga ggcgggggcg ctgcccaacg caccgaatag ttacggtcgg aggccgatcc      360

aggtcatgat gatgggcagc gcccgagtgg cggagctgct gctgctccac ggcgcggagc      420

ccaactgcgc cgaccccgcc actctcaccc gacccgtgca cgacgctgcc cgggagggct      480

tcctggacac gctggtggtg ctgcaccggg ccggggcgcg gctggacgtg cgcgatgcct      540

ggggccgtct gcccgtggac ctggctgagg agctgggcca tcgcgatgtc gcacggtacc      600

tgcgcgcggc tgcggggggc accagaggca gtaaccatgc ccgcatagat gccgcggaag      660

gtccctcaga catccccgat tgaaagaacc agagaggctc tgagaaacct cgggaaactt      720

agatcatcag tcaccgaagg tcctacaggg ccacaactgc ccccgccaca acccaccccg      780

ctttcgtagt tttcatttag aaaatagagc ttttaaaaat gtcctgcctt ttaacgtaga      840

tatatgcctt cccccactac cgtaaatgtc catttatatc attttttata tattcttata      900

aaaatgtaaa aaagaaaaac accgcttctg ccttttcact gtgttggagt tttctggagt      960

gagcactcac gccctaagcg cacattcatg tgggcatttc ttgcgagcct cgcagcctcc     1020

ggaagctgtc gacttcatga caagcatttt gtgaactagg gaagctcagg ggggttactg     1080

gcttctcttg agtcacactg ctagcaaatg gcagaaccaa agctcaaata aaaataaaat     1140

aattttcatt cattcactca aaa                                             1163


<210>  4
<211>  1163
<212>  RNA
<213>  Homo sapiens


<220>
<223>  NM_000077.3 [gi:47132606] Homo sapiens cyclin-dependent kinase 
       inhibitor 2A (melanoma, p16, inhibits CDK4) (CDKN2A), transcript 
       variant 1, (mRNA)

<400>  4
cuccuccgag cacucgcuca cggcgucccc uugccuggaa agauaccgcg gucccuccag       60

aggauuugag ggacaggguc ggagggggcu cuuccgccag caccggagga agaaagagga      120

ggggcuggcu ggucaccaga ggguggggcg gaccgcgugc gcucggcggc ugcggagagg      180

gggagagcag gcagcgggcg gcggggagca gcauggagcc ggcggcgggg agcagcaugg      240

agccuucggc ugacuggcug gccacggccg cggcccgggg ucggguagag gaggugcggg      300

cgcugcugga ggcgggggcg cugcccaacg caccgaauag uuacggucgg aggccgaucc      360

aggucaugau gaugggcagc gcccgagugg cggagcugcu gcugcuccac ggcgcggagc      420

ccaacugcgc cgaccccgcc acucucaccc gacccgugca cgacgcugcc cgggagggcu      480

uccuggacac gcugguggug cugcaccggg ccggggcgcg gcuggacgug cgcgaugccu      540

ggggccgucu gcccguggac cuggcugagg agcugggcca ucgcgauguc gcacgguacc      600

ugcgcgcggc ugcggggggc accagaggca guaaccaugc ccgcauagau gccgcggaag      660

gucccucaga cauccccgau ugaaagaacc agagaggcuc ugagaaaccu cgggaaacuu      720

agaucaucag ucaccgaagg uccuacaggg ccacaacugc ccccgccaca acccaccccg      780

cuuucguagu uuucauuuag aaaauagagc uuuuaaaaau guccugccuu uuaacguaga      840

uauaugccuu cccccacuac cguaaauguc cauuuauauc auuuuuuaua uauucuuaua      900

aaaauguaaa aaagaaaaac accgcuucug ccuuuucacu guguuggagu uuucuggagu      960

gagcacucac gcccuaagcg cacauucaug ugggcauuuc uugcgagccu cgcagccucc     1020

ggaagcuguc gacuucauga caagcauuuu gugaacuagg gaagcucagg gggguuacug     1080

gcuucucuug agucacacug cuagcaaaug gcagaaccaa agcucaaaua aaaauaaaau     1140

aauuuucauu cauucacuca aaa                                             1163


<210>  5
<211>  1267
<212>  DNA
<213>  Homo sapiens


<220>
<223>  NM_000077.4 [GI:300863097] Homo sapiens cyclin-dependent kinase 
       inhibitor 2A (CDKN2A), transcript variant 1, (DNA)

<400>  5
cgagggctgc ttccggctgg tgcccccggg ggagacccaa cctggggcga cttcaggggt       60

gccacattcg ctaagtgctc ggagttaata gcacctcctc cgagcactcg ctcacggcgt      120

ccccttgcct ggaaagatac cgcggtccct ccagaggatt tgagggacag ggtcggaggg      180

ggctcttccg ccagcaccgg aggaagaaag aggaggggct ggctggtcac cagagggtgg      240

ggcggaccgc gtgcgctcgg cggctgcgga gagggggaga gcaggcagcg ggcggcgggg      300

agcagcatgg agccggcggc ggggagcagc atggagcctt cggctgactg gctggccacg      360

gccgcggccc ggggtcgggt agaggaggtg cgggcgctgc tggaggcggg ggcgctgccc      420

aacgcaccga atagttacgg tcggaggccg atccaggtca tgatgatggg cagcgcccga      480

gtggcggagc tgctgctgct ccacggcgcg gagcccaact gcgccgaccc cgccactctc      540

acccgacccg tgcacgacgc tgcccgggag ggcttcctgg acacgctggt ggtgctgcac      600

cgggccgggg cgcggctgga cgtgcgcgat gcctggggcc gtctgcccgt ggacctggct      660

gaggagctgg gccatcgcga tgtcgcacgg tacctgcgcg cggctgcggg gggcaccaga      720

ggcagtaacc atgcccgcat agatgccgcg gaaggtccct cagacatccc cgattgaaag      780

aaccagagag gctctgagaa acctcgggaa acttagatca tcagtcaccg aaggtcctac      840

agggccacaa ctgcccccgc cacaacccac cccgctttcg tagttttcat ttagaaaata      900

gagcttttaa aaatgtcctg ccttttaacg tagatatatg ccttccccca ctaccgtaaa      960

tgtccattta tatcattttt tatatattct tataaaaatg taaaaaagaa aaacaccgct     1020

tctgcctttt cactgtgttg gagttttctg gagtgagcac tcacgcccta agcgcacatt     1080

catgtgggca tttcttgcga gcctcgcagc ctccggaagc tgtcgacttc atgacaagca     1140

ttttgtgaac tagggaagct caggggggtt actggcttct cttgagtcac actgctagca     1200

aatggcagaa ccaaagctca aataaaaata aaataatttt cattcattca ctcaaaaaaa     1260

aaaaaaa                                                               1267


<210>  6
<211>  1267
<212>  RNA
<213>  Homo sapiens


<220>
<223>  NM_000077.4 [GI:300863097] Homo sapiens cyclin-dependent kinase 
       inhibitor 2A (CDKN2A), transcript variant 1, (mRNA)

<400>  6
cgagggcugc uuccggcugg ugcccccggg ggagacccaa ccuggggcga cuucaggggu       60

gccacauucg cuaagugcuc ggaguuaaua gcaccuccuc cgagcacucg cucacggcgu      120

ccccuugccu ggaaagauac cgcggucccu ccagaggauu ugagggacag ggucggaggg      180

ggcucuuccg ccagcaccgg aggaagaaag aggaggggcu ggcuggucac cagagggugg      240

ggcggaccgc gugcgcucgg cggcugcgga gagggggaga gcaggcagcg ggcggcgggg      300

agcagcaugg agccggcggc ggggagcagc auggagccuu cggcugacug gcuggccacg      360

gccgcggccc ggggucgggu agaggaggug cgggcgcugc uggaggcggg ggcgcugccc      420

aacgcaccga auaguuacgg ucggaggccg auccagguca ugaugauggg cagcgcccga      480

guggcggagc ugcugcugcu ccacggcgcg gagcccaacu gcgccgaccc cgccacucuc      540

acccgacccg ugcacgacgc ugcccgggag ggcuuccugg acacgcuggu ggugcugcac      600

cgggccgggg cgcggcugga cgugcgcgau gccuggggcc gucugcccgu ggaccuggcu      660

gaggagcugg gccaucgcga ugucgcacgg uaccugcgcg cggcugcggg gggcaccaga      720

ggcaguaacc augcccgcau agaugccgcg gaaggucccu cagacauccc cgauugaaag      780

aaccagagag gcucugagaa accucgggaa acuuagauca ucagucaccg aagguccuac      840

agggccacaa cugcccccgc cacaacccac cccgcuuucg uaguuuucau uuagaaaaua      900

gagcuuuuaa aaauguccug ccuuuuaacg uagauauaug ccuuccccca cuaccguaaa      960

uguccauuua uaucauuuuu uauauauucu uauaaaaaug uaaaaaagaa aaacaccgcu     1020

ucugccuuuu cacuguguug gaguuuucug gagugagcac ucacgcccua agcgcacauu     1080

caugugggca uuucuugcga gccucgcagc cuccggaagc ugucgacuuc augacaagca     1140

uuuugugaac uagggaagcu cagggggguu acuggcuucu cuugagucac acugcuagca     1200

aauggcagaa ccaaagcuca aauaaaaaua aaauaauuuu cauucauuca cucaaaaaaa     1260

aaaaaaa                                                               1267


<210>  7
<211>  1464
<212>  DNA
<213>  Homo sapiens


<220>
<223>  NM_001195132.1  [GI:304376271] Homo sapiens cyclin-dependent 
       kinase inhibitor 2A (CDKN2A), trannscript variant 5, (DNA)

<400>  7
cgagggctgc ttccggctgg tgcccccggg ggagacccaa cctggggcga cttcaggggt       60

gccacattcg ctaagtgctc ggagttaata gcacctcctc cgagcactcg ctcacggcgt      120

ccccttgcct ggaaagatac cgcggtccct ccagaggatt tgagggacag ggtcggaggg      180

ggctcttccg ccagcaccgg aggaagaaag aggaggggct ggctggtcac cagagggtgg      240

ggcggaccgc gtgcgctcgg cggctgcgga gagggggaga gcaggcagcg ggcggcgggg      300

agcagcatgg agccggcggc ggggagcagc atggagcctt cggctgactg gctggccacg      360

gccgcggccc ggggtcgggt agaggaggtg cgggcgctgc tggaggcggg ggcgctgccc      420

aacgcaccga atagttacgg tcggaggccg atccaggtca tgatgatggg cagcgcccga      480

gtggcggagc tgctgctgct ccacggcgcg gagcccaact gcgccgaccc cgccactctc      540

acccgacccg tgcacgacgc tgcccgggag ggcttcctgg acacgctggt ggtgctgcac      600

cgggccgggg cgcggctgga cgtgcgcgat gcctggggcc gtctgcccgt ggacctggct      660

gaggagctgg gccatcgcga tgtcgcacgg tacctgcgcg cggctgcggg gggcaccaga      720

ggcagtaacc atgcccgcat agatgccgcg gaaggtccct cagaaatgat cggaaaccat      780

ttgtgggttt gtagaagcag gcatgcgtag ggaagctacg ggattccgcc gaggagcgcc      840

agagcctgag gcgccctttg gttatcgcaa gctggctggc tcactccgca ccaggtgcaa      900

aagatgcctg gggatgcggg aagggaaagg ccacatcttc acgccttcgc gcctggcatt      960

acatccccga ttgaaagaac cagagaggct ctgagaaacc tcgggaaact tagatcatca     1020

gtcaccgaag gtcctacagg gccacaactg cccccgccac aacccacccc gctttcgtag     1080

ttttcattta gaaaatagag cttttaaaaa tgtcctgcct tttaacgtag atatatgcct     1140

tcccccacta ccgtaaatgt ccatttatat cattttttat atattcttat aaaaatgtaa     1200

aaaagaaaaa caccgcttct gccttttcac tgtgttggag ttttctggag tgagcactca     1260

cgccctaagc gcacattcat gtgggcattt cttgcgagcc tcgcagcctc cggaagctgt     1320

cgacttcatg acaagcattt tgtgaactag ggaagctcag gggggttact ggcttctctt     1380

gagtcacact gctagcaaat ggcagaacca aagctcaaat aaaaataaaa taattttcat     1440

tcattcactc aaaaaaaaaa aaaa                                            1464


<210>  8
<211>  1464
<212>  RNA
<213>  Homo sapiens


<220>
<223>  NM_001195132.1  [GI:304376271] Homo sapiens cyclin-dependent 
       kinase inhibitor 2A (CDKN2A), trannscript variant 5, (mRNA)

<400>  8
cgagggcugc uuccggcugg ugcccccggg ggagacccaa ccuggggcga cuucaggggu       60

gccacauucg cuaagugcuc ggaguuaaua gcaccuccuc cgagcacucg cucacggcgu      120

ccccuugccu ggaaagauac cgcggucccu ccagaggauu ugagggacag ggucggaggg      180

ggcucuuccg ccagcaccgg aggaagaaag aggaggggcu ggcuggucac cagagggugg      240

ggcggaccgc gugcgcucgg cggcugcgga gagggggaga gcaggcagcg ggcggcgggg      300

agcagcaugg agccggcggc ggggagcagc auggagccuu cggcugacug gcuggccacg      360

gccgcggccc ggggucgggu agaggaggug cgggcgcugc uggaggcggg ggcgcugccc      420

aacgcaccga auaguuacgg ucggaggccg auccagguca ugaugauggg cagcgcccga      480

guggcggagc ugcugcugcu ccacggcgcg gagcccaacu gcgccgaccc cgccacucuc      540

acccgacccg ugcacgacgc ugcccgggag ggcuuccugg acacgcuggu ggugcugcac      600

cgggccgggg cgcggcugga cgugcgcgau gccuggggcc gucugcccgu ggaccuggcu      660

gaggagcugg gccaucgcga ugucgcacgg uaccugcgcg cggcugcggg gggcaccaga      720

ggcaguaacc augcccgcau agaugccgcg gaaggucccu cagaaaugau cggaaaccau      780

uuguggguuu guagaagcag gcaugcguag ggaagcuacg ggauuccgcc gaggagcgcc      840

agagccugag gcgcccuuug guuaucgcaa gcuggcuggc ucacuccgca ccaggugcaa      900

aagaugccug gggaugcggg aagggaaagg ccacaucuuc acgccuucgc gccuggcauu      960

acauccccga uugaaagaac cagagaggcu cugagaaacc ucgggaaacu uagaucauca     1020

gucaccgaag guccuacagg gccacaacug cccccgccac aacccacccc gcuuucguag     1080

uuuucauuua gaaaauagag cuuuuaaaaa uguccugccu uuuaacguag auauaugccu     1140

ucccccacua ccguaaaugu ccauuuauau cauuuuuuau auauucuuau aaaaauguaa     1200

aaaagaaaaa caccgcuucu gccuuuucac uguguuggag uuuucuggag ugagcacuca     1260

cgcccuaagc gcacauucau gugggcauuu cuugcgagcc ucgcagccuc cggaagcugu     1320

cgacuucaug acaagcauuu ugugaacuag ggaagcucag ggggguuacu ggcuucucuu     1380

gagucacacu gcuagcaaau ggcagaacca aagcucaaau aaaaauaaaa uaauuuucau     1440

ucauucacuc aaaaaaaaaa aaaa                                            1464


<210>  9
<211>  1164
<212>  DNA
<213>  Homo sapiens


<220>
<223>  NM_058195.3  [GI:300863095] Homo sapiens cyclin-dependent kinase 
       inhibitor 2A (CDKN2A), transcript variant 4, (DNA)

<400>  9
cgctcaggga aggcgggtgc gcgcctgcgg ggcggagatg ggcagggggc ggtgcgtggg       60

tcccagtctg cagttaaggg ggcaggagtg gcgctgctca cctctggtgc caaagggcgg      120

cgcagcggct gccgagctcg gccctggagg cggcgagaac atggtgcgca ggttcttggt      180

gaccctccgg attcggcgcg cgtgcggccc gccgcgagtg agggttttcg tggttcacat      240

cccgcggctc acgggggagt gggcagcgcc aggggcgccc gccgctgtgg ccctcgtgct      300

gatgctactg aggagccagc gtctagggca gcagccgctt cctagaagac caggtcatga      360

tgatgggcag cgcccgagtg gcggagctgc tgctgctcca cggcgcggag cccaactgcg      420

ccgaccccgc cactctcacc cgacccgtgc acgacgctgc ccgggagggc ttcctggaca      480

cgctggtggt gctgcaccgg gccggggcgc ggctggacgt gcgcgatgcc tggggccgtc      540

tgcccgtgga cctggctgag gagctgggcc atcgcgatgt cgcacggtac ctgcgcgcgg      600

ctgcgggggg caccagaggc agtaaccatg cccgcataga tgccgcggaa ggtccctcag      660

acatccccga ttgaaagaac cagagaggct ctgagaaacc tcgggaaact tagatcatca      720

gtcaccgaag gtcctacagg gccacaactg cccccgccac aacccacccc gctttcgtag      780

ttttcattta gaaaatagag cttttaaaaa tgtcctgcct tttaacgtag atatatgcct      840

tcccccacta ccgtaaatgt ccatttatat cattttttat atattcttat aaaaatgtaa      900

aaaagaaaaa caccgcttct gccttttcac tgtgttggag ttttctggag tgagcactca      960

cgccctaagc gcacattcat gtgggcattt cttgcgagcc tcgcagcctc cggaagctgt     1020

cgacttcatg acaagcattt tgtgaactag ggaagctcag gggggttact ggcttctctt     1080

gagtcacact gctagcaaat ggcagaacca aagctcaaat aaaaataaaa taattttcat     1140

tcattcactc aaaaaaaaaa aaaa                                            1164


<210>  10
<211>  1164
<212>  RNA
<213>  Homo sapiens


<220>
<223>  NM_058195.3  [GI:300863095] Homo sapiens cyclin-dependent kinase 
       inhibitor 2A (CDKN2A), transcript variant 4, (mRNA)

<400>  10
cgcucaggga aggcgggugc gcgccugcgg ggcggagaug ggcagggggc ggugcguggg       60

ucccagucug caguuaaggg ggcaggagug gcgcugcuca ccucuggugc caaagggcgg      120

cgcagcggcu gccgagcucg gcccuggagg cggcgagaac auggugcgca gguucuuggu      180

gacccuccgg auucggcgcg cgugcggccc gccgcgagug aggguuuucg ugguucacau      240

cccgcggcuc acgggggagu gggcagcgcc aggggcgccc gccgcugugg cccucgugcu      300

gaugcuacug aggagccagc gucuagggca gcagccgcuu ccuagaagac caggucauga      360

ugaugggcag cgcccgagug gcggagcugc ugcugcucca cggcgcggag cccaacugcg      420

ccgaccccgc cacucucacc cgacccgugc acgacgcugc ccgggagggc uuccuggaca      480

cgcugguggu gcugcaccgg gccggggcgc ggcuggacgu gcgcgaugcc uggggccguc      540

ugcccgugga ccuggcugag gagcugggcc aucgcgaugu cgcacgguac cugcgcgcgg      600

cugcgggggg caccagaggc aguaaccaug cccgcauaga ugccgcggaa ggucccucag      660

acauccccga uugaaagaac cagagaggcu cugagaaacc ucgggaaacu uagaucauca      720

gucaccgaag guccuacagg gccacaacug cccccgccac aacccacccc gcuuucguag      780

uuuucauuua gaaaauagag cuuuuaaaaa uguccugccu uuuaacguag auauaugccu      840

ucccccacua ccguaaaugu ccauuuauau cauuuuuuau auauucuuau aaaaauguaa      900

aaaagaaaaa caccgcuucu gccuuuucac uguguuggag uuuucuggag ugagcacuca      960

cgcccuaagc gcacauucau gugggcauuu cuugcgagcc ucgcagccuc cggaagcugu     1020

cgacuucaug acaagcauuu ugugaacuag ggaagcucag ggggguuacu ggcuucucuu     1080

gagucacacu gcuagcaaau ggcagaacca aagcucaaau aaaaauaaaa uaauuuucau     1140

ucauucacuc aaaaaaaaaa aaaa                                            1164


<210>  11
<211>  897
<212>  DNA
<213>  Homo sapiens


<220>
<223>  NM_058196.1  [GI:17738295] Homo sapiens cyclin-dependent kinase 
       inhibitor 2A (melanoma, p16, inhibits CDK4) (CDKN2A), transcript 
       variant 2, (DNA).

<400>  11
tgtgtggggg tctgcttggc ggtgaggggg ctctacacaa gcttcctttc cgtcatgccg       60

gcccccaccc tggctctgac cattctgttc tctctggcag gtcatgatga tgggcagcgc      120

ccgagtggcg gagctgctgc tgctccacgg cgcggagccc aactgcgccg accccgccac      180

tctcacccga cccgtgcacg acgctgcccg ggagggcttc ctggacacgc tggtggtgct      240

gcaccgggcc ggggcgcggc tggacgtgcg cgatgcctgg ggccgtctgc ccgtggacct      300

ggctgaggag ctgggccatc gcgatgtcgc acggtacctg cgcgcggctg cggggggcac      360

cagaggcagt aaccatgccc gcatagatgc cgcggaaggt ccctcagaca tccccgattg      420

aaagaaccag agaggctctg agaaacctcg ggaaacttag atcatcagtc accgaaggtc      480

ctacagggcc acaactgccc ccgccacaac ccaccccgct ttcgtagttt tcatttagaa      540

aatagagctt ttaaaaatgt cctgcctttt aacgtagata taagccttcc cccactaccg      600

taaatgtcca tttatatcat tttttatata ttcttataaa aatgtaaaaa agaaaaacac      660

cgcttctgcc ttttcactgt gttggagttt tctggagtga gcactcacgc cctaagcgca      720

cattcatgtg ggcatttctt gcgagcctcg cagcctccgg aagctgtcga cttcatgaca      780

agcattttgt gaactaggga agctcagggg ggttactggc ttctcttgag tcacactgct      840

agcaaatggc agaaccaaag ctcaaataaa aataaaataa ttttcattca ttcactc         897


<210>  12
<211>  897
<212>  RNA
<213>  Homo sapiens


<220>
<223>  NM_058196.1  [GI:17738295] Homo sapiens cyclin-dependent kinase 
       inhibitor 2A (melanoma, p16, inhibits CDK4) (CDKN2A), transcript 
       variant 2, (mRNA).

<400>  12
uguguggggg ucugcuuggc ggugaggggg cucuacacaa gcuuccuuuc cgucaugccg       60

gcccccaccc uggcucugac cauucuguuc ucucuggcag gucaugauga ugggcagcgc      120

ccgaguggcg gagcugcugc ugcuccacgg cgcggagccc aacugcgccg accccgccac      180

ucucacccga cccgugcacg acgcugcccg ggagggcuuc cuggacacgc ugguggugcu      240

gcaccgggcc ggggcgcggc uggacgugcg cgaugccugg ggccgucugc ccguggaccu      300

ggcugaggag cugggccauc gcgaugucgc acgguaccug cgcgcggcug cggggggcac      360

cagaggcagu aaccaugccc gcauagaugc cgcggaaggu cccucagaca uccccgauug      420

aaagaaccag agaggcucug agaaaccucg ggaaacuuag aucaucaguc accgaagguc      480

cuacagggcc acaacugccc ccgccacaac ccaccccgcu uucguaguuu ucauuuagaa      540

aauagagcuu uuaaaaaugu ccugccuuuu aacguagaua uaagccuucc cccacuaccg      600

uaaaugucca uuuauaucau uuuuuauaua uucuuauaaa aauguaaaaa agaaaaacac      660

cgcuucugcc uuuucacugu guuggaguuu ucuggaguga gcacucacgc ccuaagcgca      720

cauucaugug ggcauuucuu gcgagccucg cagccuccgg aagcugucga cuucaugaca      780

agcauuuugu gaacuaggga agcucagggg gguuacuggc uucucuugag ucacacugcu      840

agcaaauggc agaaccaaag cucaaauaaa aauaaaauaa uuuucauuca uucacuc         897


<210>  13
<211>  1235
<212>  DNA
<213>  Homo sapiens


<220>
<223>  NM_058197.4  [GI:300863098] Homo sapiens cyclin-dependent kinase 
       inhibitor 2A (CDKN2A), transcript variant 3, (DNA).

<400>  13
atggagccgg cggcggggag cagcatggag ccttcggctg actggctggc cacggccgcg       60

gcccggggtc gggtagagga ggtgcgggcg ctgctggagg cgggggcgct gcccaacgca      120

ccgaatagtt acggtcggag gccgatccag gtgggtagag ggtctgcagc gggagcaggg      180

gatggcgggc gactctggag gacgaagttt gcaggggaat tggaatcagg tagcgcttcg      240

attctccgga aaaaggggag gcttcctggg gagttttcag aaggggtttg taatcacaga      300

cctcctcctg gcgacgccct gggggcttgg gaagccaagg aagaggaatg aggagccacg      360

cgcgtacaga tctctcgaat gctgagaaga tctgaagggg ggaacatatt tgtattagat      420

ggaagtcatg atgatgggca gcgcccgagt ggcggagctg ctgctgctcc acggcgcgga      480

gcccaactgc gccgaccccg ccactctcac ccgacccgtg cacgacgctg cccgggaggg      540

cttcctggac acgctggtgg tgctgcaccg ggccggggcg cggctggacg tgcgcgatgc      600

ctggggccgt ctgcccgtgg acctggctga ggagctgggc catcgcgatg tcgcacggta      660

cctgcgcgcg gctgcggggg gcaccagagg cagtaaccat gcccgcatag atgccgcgga      720

aggtccctca gacatccccg attgaaagaa ccagagaggc tctgagaaac ctcgggaaac      780

ttagatcatc agtcaccgaa ggtcctacag ggccacaact gcccccgcca caacccaccc      840

cgctttcgta gttttcattt agaaaataga gcttttaaaa atgtcctgcc ttttaacgta      900

gatatatgcc ttcccccact accgtaaatg tccatttata tcatttttta tatattctta      960

taaaaatgta aaaaagaaaa acaccgcttc tgccttttca ctgtgttgga gttttctgga     1020

gtgagcactc acgccctaag cgcacattca tgtgggcatt tcttgcgagc ctcgcagcct     1080

ccggaagctg tcgacttcat gacaagcatt ttgtgaacta gggaagctca ggggggttac     1140

tggcttctct tgagtcacac tgctagcaaa tggcagaacc aaagctcaaa taaaaataaa     1200

ataattttca ttcattcact caaaaaaaaa aaaaa                                1235


<210>  14
<211>  1235
<212>  RNA
<213>  Homo sapiens


<220>
<223>  NM_058197.4  [GI:300863098] Homo sapiens cyclin-dependent kinase 
       inhibitor 2A (CDKN2A), transcript variant 3, (mRNA).

<400>  14
auggagccgg cggcggggag cagcauggag ccuucggcug acuggcuggc cacggccgcg       60

gcccgggguc ggguagagga ggugcgggcg cugcuggagg cgggggcgcu gcccaacgca      120

ccgaauaguu acggucggag gccgauccag guggguagag ggucugcagc gggagcaggg      180

gauggcgggc gacucuggag gacgaaguuu gcaggggaau uggaaucagg uagcgcuucg      240

auucuccgga aaaaggggag gcuuccuggg gaguuuucag aagggguuug uaaucacaga      300

ccuccuccug gcgacgcccu gggggcuugg gaagccaagg aagaggaaug aggagccacg      360

cgcguacaga ucucucgaau gcugagaaga ucugaagggg ggaacauauu uguauuagau      420

ggaagucaug augaugggca gcgcccgagu ggcggagcug cugcugcucc acggcgcgga      480

gcccaacugc gccgaccccg ccacucucac ccgacccgug cacgacgcug cccgggaggg      540

cuuccuggac acgcuggugg ugcugcaccg ggccggggcg cggcuggacg ugcgcgaugc      600

cuggggccgu cugcccgugg accuggcuga ggagcugggc caucgcgaug ucgcacggua      660

ccugcgcgcg gcugcggggg gcaccagagg caguaaccau gcccgcauag augccgcgga      720

aggucccuca gacauccccg auugaaagaa ccagagaggc ucugagaaac cucgggaaac      780

uuagaucauc agucaccgaa gguccuacag ggccacaacu gcccccgcca caacccaccc      840

cgcuuucgua guuuucauuu agaaaauaga gcuuuuaaaa auguccugcc uuuuaacgua      900

gauauaugcc uucccccacu accguaaaug uccauuuaua ucauuuuuua uauauucuua      960

uaaaaaugua aaaaagaaaa acaccgcuuc ugccuuuuca cuguguugga guuuucugga     1020

gugagcacuc acgcccuaag cgcacauuca ugugggcauu ucuugcgagc cucgcagccu     1080

ccggaagcug ucgacuucau gacaagcauu uugugaacua gggaagcuca gggggguuac     1140

uggcuucucu ugagucacac ugcuagcaaa uggcagaacc aaagcucaaa uaaaaauaaa     1200

auaauuuuca uucauucacu caaaaaaaaa aaaaa                                1235


<210>  15
<211>  156
<212>  PRT
<213>  Homo sapiens


<220>
<223>  p16 protein sequence

<400>  15

Met Glu Pro Ala Ala Gly Ser Ser Met Glu Pro Ser Ala Asp Trp Leu 
1               5                   10                  15      


Ala Thr Ala Ala Ala Arg Gly Arg Val Glu Glu Val Arg Ala Leu Leu 
            20                  25                  30          


Glu Ala Gly Ala Leu Pro Asn Ala Pro Asn Ser Tyr Gly Arg Arg Pro 
        35                  40                  45              


Ile Gln Val Met Met Met Gly Ser Ala Arg Val Ala Glu Leu Leu Leu 
    50                  55                  60                  


Leu His Gly Ala Glu Pro Asn Cys Ala Asp Pro Ala Thr Leu Thr Arg 
65                  70                  75                  80  


Pro Val His Asp Ala Ala Arg Glu Gly Phe Leu Asp Thr Leu Val Val 
                85                  90                  95      


Leu His Arg Ala Gly Ala Arg Leu Asp Val Arg Asp Ala Trp Gly Arg 
            100                 105                 110         


Leu Pro Val Asp Leu Ala Glu Glu Leu Gly His Arg Asp Val Ala Arg 
        115                 120                 125             


Tyr Leu Arg Ala Ala Ala Gly Gly Thr Arg Gly Ser Asn His Ala Arg 
    130                 135                 140                 


Ile Asp Ala Ala Glu Gly Pro Ser Asp Ile Pro Asp 
145                 150                 155     


<210>  16
<211>  77
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-26b

<400>  16
ccgggaccca guucaaguaa uucaggauag guugugugcu guccagccug uucuccauua       60

cuuggcucgg ggaccgg                                                      77


<210>  17
<211>  77
<212>  RNA
<213>  Artificial sequence

<220>
<223>  anti-hsa-miR-26b

<400>  17
ccgguccccg agccaaguaa uggagaacag gcuggacagc acacaaccua uccugaauua       60

cuugaacugg gucccgg                                                      77


<210>  18
<211>  110
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-181a-1

<400>  18
ugaguuuuga gguugcuuca gugaacauuc aacgcugucg gugaguuugg aauuaaaauc       60

aaaaccaucg accguugauu guacccuaug gcuaaccauc aucuacucca                 110


<210>  19
<211>  110
<212>  RNA
<213>  Artificial sequence

<220>
<223>  anti-hsa-miR-181a-1

<400>  19
uggaguagau gaugguuagc cauaggguac aaucaacggu cgaugguuuu gauuuuaauu       60

ccaaacucac cgacagcguu gaauguucac ugaagcaacc ucaaaacuca                 110


<210>  20
<211>  110
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-181-2

<400>  20
agaagggcua ucaggccagc cuucagagga cuccaaggaa cauucaacgc ugucggugag       60

uuugggauuu gaaaaaacca cugaccguug acuguaccuu gggguccuua                 110


<210>  21
<211>  110
<212>  RNA
<213>  Artificial sequence

<220>
<223>  anti-hsa-miR-181-2

<400>  21
uaaggacccc aagguacagu caacggucag ugguuuuuuc aaaucccaaa cucaccgaca       60

gcguugaaug uuccuuggag uccucugaag gcuggccuga uagcccuucu                 110


<210>  22
<211>  110
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-210

<400>  22
acccggcagu gccuccaggc gcagggcagc cccugcccac cgcacacugc gcugccccag       60

acccacugug cgugugacag cggcugaucu gugccugggc agcgcgaccc                 110


<210>  23
<211>  110
<212>  RNA
<213>  Artificial sequence

<220>
<223>  anti-hsa-miR-210

<400>  23
gggucgcgcu gcccaggcac agaucagccg cugucacacg cacagugggu cuggggcagc       60

gcagugugcg gugggcaggg gcugcccugc gccuggaggc acugccgggu                 110


<210>  24
<211>  98
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-424

<400>  24
cgaggggaua cagcagcaau ucauguuuug aaguguucua aaugguucaa aacgugaggc       60

gcugcuauac ccccucgugg ggaagguaga aggugggg                               98


<210>  25
<211>  98
<212>  RNA
<213>  Artificial sequence

<220>
<223>  anti-hsa-miR-424

<400>  25
ccccaccuuc uaccuucccc acgagggggu auagcagcgc cucacguuuu gaaccauuua       60

gaacacuuca aaacaugaau ugcugcugua uccccucg                               98


<210>  26
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-let-7b

<400>  26
ugagguagua gguugugugg uu                                                22


<210>  27
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-let-7c

<400>  27
ugagguagua gguuguaugg uu                                                22


<210>  28
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-1180

<400>  28
uuuccggcuc gcgugggugu gu                                                22


<210>  29
<211>  23
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-1184

<400>  29
ccugcagcga cuugauggcu ucc                                               23


<210>  30
<211>  20
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-1205

<400>  30
ucugcagggu uugcuuugag                                                   20


<210>  31
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-122

<400>  31
uggaguguga caaugguguu ug                                                22


<210>  32
<211>  21
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-1253

<400>  32
agagaagaag aucagccugc a                                                 21


<210>  33
<211>  24
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-125a-5p

<400>  33
ucccugagac ccuuuaaccu guga                                              24


<210>  34
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-125b

<400>  34
ucccugagac ccuaacuugu ga                                                22


<210>  35
<211>  22
<212>  RNA
<213>  Homo sapiens

<220>
<223>  hsa-miR-1269

<400>  35
cuggacugag ccgugcuacu gg                                                22


<210>  36
<211>  23
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-1270

<400>  36
cuggagauau ggaagagcug ugu                                               23


<210>  37
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-1271

<400>  37
cuuggcaccu agcaagcacu ca                                                22


<210>  38
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-127-3p

<400>  38
ucggauccgu cugagcuugg cu                                                22


<210>  39
<211>  21
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-128

<400>  39
ucacagugaa ccggucucuu u                                                 21


<210>  40
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-1283

<400>  40
ucuacaaagg aaagcgcuuu cu                                                22


<210>  41
<211>  21
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-1288

<400>  41
uggacugccc ugaucuggag a                                                 21


<210>  42
<211>  24
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-1301

<400>  42
uugcagcugc cugggaguga cuuc                                              24


<210>  43
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-130b

<400>  43
cagugcaaug augaaagggc au                                                22


<210>  44
<211>  22
<212>  RNA
<213>  Homo sapiens

<220>
<223>  hsa-miR-134

<400>  44
ugugacuggu ugaccagagg gg                                                22


<210>  45
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-146b-5p

<400>  45
ugagaacuga auuccauagg cu                                                22


<210>  46
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-148a*

<400>  46
aaaguucuga gacacuccga cu                                                22


<210>  47
<211>  23
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-181a

<400>  47
aacauucaac gcugucggug agu                                               23


<210>  48
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-181a*

<400>  48
accaucgacc guugauugua cc                                                22


<210>  49
<211>  24
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-182

<400>  49
uuuggcaaug guagaacuca cacu                                              24


<210>  50
<211>  21
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-182*

<400>  50
ugguucuaga cuugccaacu a                                                 21


<210>  51
<211>  27
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-1826

<400>  51
auugaucauc gacacuucga acgcaau                                           27


<210>  52
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-184

<400>  52
uggacggaga acugauaagg gu                                                22


<210>  53
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-191*

<400>  53
gcugcgcuug gauuucgucc cc                                                22


<210>  54
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-193a-3p

<400>  54
aacuggccua caaaguccca gu                                                22


<210>  55
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-193b

<400>  55
aacuggcccu caaagucccg cu                                                22


<210>  56
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-196a*

<400>  56
cggcaacaag aaacugccug ag                                                22


<210>  57
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-197

<400>  57
uucaccaccu ucuccaccca gc                                                22


<210>  58
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-19b-2*

<400>  58
aguuuugcag guuugcauuu ca                                                22


<210>  59
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-200b

<400>  59
uaauacugcc ugguaaugau ga                                                22


<210>  60
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-203

<400>  60
gugaaauguu uaggaccacu ag                                                22


<210>  61
<211>  22
<212>  DNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-206

<400>  61
uggaauguaa ggaagugugu gg                                                22


<210>  62
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-208a

<400>  62
auaagacgag caaaaagcuu gu                                                22


<210>  63
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-208b

<400>  63
auaagacgaa caaaagguuu gu                                                22


<210>  64
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-21

<400>  64
uagcuuauca gacugauguu ga                                                22


<210>  65
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-210

<400>  65
cugugcgugu gacagcggcu ga                                                22


<210>  66
<211>  21
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-218

<400>  66
uugugcuuga ucuaaccaug u                                                 21


<210>  67
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-22*

<400>  67
aguucuucag uggcaagcuu ua                                                22


<210>  68
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-26a

<400>  68
uucaaguaau ccaggauagg cu                                                22


<210>  69
<211>  21
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-26b

<400>  69
uucaaguaau ucaggauagg u                                                 21


<210>  70
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-30a

<400>  70
uguaaacauc cucgacugga ag                                                22


<210>  71
<211>  23
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-30c

<400>  71
uguaaacauc cuacacucuc agc                                               23


<210>  72
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-30c-2*

<400>  72
cugggagaag gcuguuuacu cu                                                22


<210>  73
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-30d

<400>  73
uguaaacauc cccgacugga ag                                                22


<210>  74
<211>  23
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-330-3p

<400>  74
gcaaagcaca cggccugcag aga                                               23


<210>  75
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-340

<400>  75
uuauaaagca augagacuga uu                                                22


<210>  76
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-34a

<400>  76
uggcaguguc uuagcugguu gu                                                22


<210>  77
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-361-5p

<400>  77
uuaucagaau cuccaggggu ac                                                22


<210>  78
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-365

<400>  78
uaaugccccu aaaaauccuu au                                                22


<210>  79
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-367*

<400>  79
acuguugcua auaugcaacu cu                                                22


<210>  80
<211>  23
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-372

<400>  80
aaagugcugc gacauuugag cgu                                               23


<210>  81
<211>  23
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-373

<400>  81
gaagugcuuc gauuuugggg ugu                                               23


<210>  82
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-378*

<400>  82
cuccugacuc cagguccugu gu                                                22


<210>  83
<211>  21
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-410

<400>  83
aauauaacac agauggccug u                                                 21


<210>  84
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-424

<400>  84
cagcagcaau ucauguuuug aa                                                22


<210>  85
<211>  23
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-432

<400>  85
ucuuggagua ggucauuggg ugg                                               23


<210>  86
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-452

<400>  86
aacuguuugc agaggaaacu ga                                                22


<210>  87
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-483-5p

<400>  87
aagacgggag gaaagaaggg ag                                                22


<210>  88
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-491-3p

<400>  88
cuuaugcaag auucccuucu ac                                                22


<210>  89
<211>  23
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-492

<400>  89
aggaccugcg ggacaagauu cuu                                               23


<210>  90
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-497*

<400>  90
caaaccacac ugugguguua ga                                                22


<210>  91
<211>  23
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-500

<400>  91
uaauccuugc uaccugggug aga                                               23


<210>  92
<211>  23
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-503

<400>  92
uagcagcggg aacaguucug cag                                               23


<210>  93
<211>  23
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-518c*

<400>  93
ucucuggagg gaagcacuuu cug                                               23


<210>  94
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-518e* // hsa-miR-519a* // hsa-miR-519b-5p // 
       hsa-miR-519c-5p // hsa-miR-522* // hsa-miR-523*

<400>  94
cucuagaggg aagcgcuuuc ug                                                22


<210>  95
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-522

<400>  95
aaaaugguuc ccuuuagagu gu                                                22


<210>  96
<211>  25
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-541*

<400>  96
aaaggauucu gcugucgguc ccacu                                             25


<210>  97
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-544

<400>  97
auucugcauu uuuagcaagu uc                                                22


<210>  98
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-548a-3p

<400>  98
caaaacuggc aauuacuuuu gc                                                22


<210>  99
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-548i

<400>  99
aaaaguaauu gcggauuuug cc                                                22


<210>  100
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-548o

<400>  100
ccaaaacugc aguuacuuuu gc                                                22


<210>  101
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-576-3p

<400>  101
aagaugugga aaaauuggaa uc                                                22


<210>  102
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-576-5p

<400>  102
auucuaauuu cuccacgucu uu                                                22


<210>  103
<211>  21
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-578

<400>  103
cuucuugugc ucuaggauug u                                                 21


<210>  104
<211>  21
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-588

<400>  104
uuggccacaa uggguuagaa c                                                 21


<210>  105
<211>  24
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-589*

<400>  105
ucagaacaaa ugccgguucc caga                                              24


<210>  106
<211>  25
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-593*

<400>  106
aggcaccagc caggcauugc ucagc                                             25


<210>  107
<211>  21
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-596

<400>  107
aagccugccc ggcuccucgg g                                                 21


<210>  108
<211>  25
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-658

<400>  108
ggcggaggga aguagguccg uuggu                                             25


<210>  109
<211>  21
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-671-3p

<400>  109
uccgguucuc agggcuccac c                                                 21


<210>  110
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-7-1*

<400>  110
caacaaauca cagucugcca ua                                                22


<210>  111
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-7-2*

<400>  111
caacaaaucc cagucuaccu aa                                                22


<210>  112
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-744*

<400>  112
cuguugccac uaaccucaac cu                                                22


<210>  113
<211>  23
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-767-5p

<400>  113
ugcaccaugg uugucugagc aug                                               23


<210>  114
<211>  22
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-874

<400>  114
cugcccuggc ccgagggacc ga                                                22


<210>  115
<211>  23
<212>  RNA
<213>  Homo sapiens


<220>
<223>  hsa-miR-9

<400>  115
ucuuugguua ucuagcugua uga                                               23


<210>  116
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-let-7b

<400>  116
aaccacacaa ccuacuaccu ca                                                22


<210>  117
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-let-7c

<400>  117
aaccauacaa ccuacuaccu ca                                                22


<210>  118
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-1180

<400>  118
acacacccac gcgagccgga aa                                                22


<210>  119
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-1184

<400>  119
ggaagccauc aagucgcugc agg                                               23


<210>  120
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-1205

<400>  120
cucaaagcaa acccugcaga                                                   20


<210>  121
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-122

<400>  121
caaacaccau ugucacacuc ca                                                22


<210>  122
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-1253

<400>  122
ugcaggcuga ucuucuucuc u                                                 21


<210>  123
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-125a-5p

<400>  123
ucacagguua aagggucuca ggga                                              24


<210>  124
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-125b

<400>  124
ucacaaguua gggucucagg ga                                                22


<210>  125
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-1269

<400>  125
ccaguagcac ggcucagucc ag                                                22


<210>  126
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-1270

<400>  126
acacagcucu uccauaucuc cag                                               23


<210>  127
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-1271

<400>  127
ugagugcuug cuaggugcca ag                                                22


<210>  128
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-127-3p

<400>  128
agccaagcuc agacggaucc ga                                                22


<210>  129
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-128

<400>  129
aaagagaccg guucacugug a                                                 21


<210>  130
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-1283

<400>  130
agaaagcgcu uuccuuugua ga                                                22


<210>  131
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-1288

<400>  131
ucuccagauc agggcagucc a                                                 21


<210>  132
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-1301

<400>  132
gaagucacuc ccaggcagcu gcaa                                              24


<210>  133
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-130b

<400>  133
augcccuuuc aucauugcac ug                                                22


<210>  134
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-134

<400>  134
ccccucuggu caaccaguca ca                                                22


<210>  135
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-146b-5p

<400>  135
agccuaugga auucaguucu ca                                                22


<210>  136
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-148a*

<400>  136
agucggagug ucucagaacu uu                                                22


<210>  137
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-181a

<400>  137
acucaccgac agcguugaau guu                                               23


<210>  138
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-181a*

<400>  138
gguacaauca acggucgaug gu                                                22


<210>  139
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-182

<400>  139
agugugaguu cuaccauugc caaa                                              24


<210>  140
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-182*

<400>  140
uaguuggcaa gucuagaacc a                                                 21


<210>  141
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-1826

<400>  141
auugcguucg aagugucgau gaucaau                                           27


<210>  142
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-184

<400>  142
acccuuauca guucuccguc ca                                                22


<210>  143
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-191*

<400>  143
ggggacgaaa uccaagcgca gc                                                22


<210>  144
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-193a-3p

<400>  144
acugggacuu uguaggccag uu                                                22


<210>  145
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-193b

<400>  145
agcgggacuu ugagggccag uu                                                22


<210>  146
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-196a*

<400>  146
cucaggcagu uucuuguugc cg                                                22


<210>  147
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-197

<400>  147
gcugggugga gaagguggug aa                                                22


<210>  148
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-19b-2*

<400>  148
ugaaaugcaa accugcaaaa cu                                                22


<210>  149
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-200b

<400>  149
ucaucauuac caggcaguau ua                                                22


<210>  150
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-203

<400>  150
cuaguggucc uaaacauuuc ac                                                22


<210>  151
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-206

<400>  151
ccacacacuu ccuuacauuc ca                                                22


<210>  152
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-208a

<400>  152
acaagcuuuu ugcucgucuu au                                                22


<210>  153
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-208b

<400>  153
acaaaccuuu uguucgucuu au                                                22


<210>  154
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-21

<400>  154
ucaacaucag ucugauaagc ua                                                22


<210>  155
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-210

<400>  155
ucagccgcug ucacacgcac ag                                                22


<210>  156
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-218

<400>  156
acaugguuag aucaagcaca a                                                 21


<210>  157
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-22*

<400>  157
uaaagcuugc cacugaagaa cu                                                22


<210>  158
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-26a

<400>  158
agccuauccu ggauuacuug aa                                                22


<210>  159
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-26b

<400>  159
accuauccug aauuacuuga a                                                 21


<210>  160
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-30a

<400>  160
cuuccagucg aggauguuua ca                                                22


<210>  161
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-30c

<400>  161
gcugagagug uaggauguuu aca                                               23


<210>  162
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-30c-2*

<400>  162
agaguaaaca gccuucuccc ag                                                22


<210>  163
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-30d

<400>  163
cuuccagucg gggauguuua ca                                                22


<210>  164
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-330-3p

<400>  164
ucucugcagg ccgugugcuu ugc                                               23


<210>  165
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-340

<400>  165
aaucagucuc auugcuuuau aa                                                22


<210>  166
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-34a

<400>  166
acaaccagcu aagacacugc ca                                                22


<210>  167
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-361-5p

<400>  167
guaccccugg agauucugau aa                                                22


<210>  168
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-365

<400>  168
auaaggauuu uuaggggcau ua                                                22


<210>  169
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-367*

<400>  169
agaguugcau auuagcaaca gu                                                22


<210>  170
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-372

<400>  170
acgcucaaau gucgcagcac uuu                                               23


<210>  171
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-373

<400>  171
acaccccaaa aucgaagcac uuc                                               23


<210>  172
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-378*

<400>  172
acacaggacc uggagucagg ag                                                22


<210>  173
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-410

<400>  173
acaggccauc uguguuauau u                                                 21


<210>  174
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-424

<400>  174
uucaaaacau gaauugcugc ug                                                22


<210>  175
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-432

<400>  175
ccacccaaug accuacucca aga                                               23


<210>  176
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-452

<400>  176
ucaguuuccu cugcaaacag uu                                                22


<210>  177
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-483-5p

<400>  177
cucccuucuu uccucccguc uu                                                22


<210>  178
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-491-3p

<400>  178
guagaaggga aucuugcaua ag                                                22


<210>  179
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-492

<400>  179
aagaaucuug ucccgcaggu ccu                                               23


<210>  180
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-497*

<400>  180
ucuaacacca cagugugguu ug                                                22


<210>  181
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-500

<400>  181
ucucacccag guagcaagga uua                                               23


<210>  182
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-503

<400>  182
cugcagaacu guucccgcug cua                                               23


<210>  183
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-518c*

<400>  183
cagaaagugc uucccuccag aga                                               23


<210>  184
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-518e* // hsa-miR-519a* // hsa-miR-519b-5p // 
       hsa-miR-519c-5p // hsa-miR-522* // hsa-miR-523*

<400>  184
cagaaagcgc uucccucuag ag                                                22


<210>  185
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-522

<400>  185
acacucuaaa gggaaccauu uu                                                22


<210>  186
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-541*

<400>  186
agugggaccg acagcagaau ccuuu                                             25


<210>  187
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-544

<400>  187
gaacuugcua aaaaugcaga au                                                22


<210>  188
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-548a-3p

<400>  188
gcaaaaguaa uugccaguuu ug                                                22


<210>  189
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-548i

<400>  189
ggcaaaaucc gcaauuacuu uu                                                22


<210>  190
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-548o

<400>  190
gcaaaaguaa cugcaguuuu gg                                                22


<210>  191
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-576-3p

<400>  191
gauuccaauu uuuccacauc uu                                                22


<210>  192
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-576-5p

<400>  192
aaagacgugg agaaauuaga au                                                22


<210>  193
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-578

<400>  193
acaauccuag agcacaagaa g                                                 21


<210>  194
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-588

<400>  194
guucuaaccc auuguggcca a                                                 21


<210>  195
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-589*

<400>  195
ucugggaacc ggcauuuguu cuga                                              24


<210>  196
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-593*

<400>  196
gcugagcaau gccuggcugg ugccu                                             25


<210>  197
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-596

<400>  197
cccgaggagc cgggcaggcu u                                                 21


<210>  198
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-658

<400>  198
accaacggac cuacuucccu ccgcc                                             25


<210>  199
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-671-3p

<400>  199
gguggagccc ugagaaccgg a                                                 21


<210>  200
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-7-1*

<400>  200
uauggcagac ugugauuugu ug                                                22


<210>  201
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-7-2*

<400>  201
uuagguagac ugggauuugu ug                                                22


<210>  202
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-744*

<400>  202
agguugaggu uaguggcaac ag                                                22


<210>  203
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-767-5p

<400>  203
caugcucaga caaccauggu gca                                               23


<210>  204
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-874

<400>  204
ucggucccuc gggccagggc ag                                                22


<210>  205
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  anti-hsa-miR-9

<400>  205
ucauacagcu agauaaccaa aga                                               23


<210>  206
<211>  26740
<212>  DNA
<213>  Homo sapiens


<220>
<223>  Homo sapiens chromosome 9, reference assembly, complete sequence,
       accession no. NC_000009.10 - p16 genomic sequence

<400>  206
cgctcaggga aggcgggtgc gcgcctgcgg ggcggagatg ggcagggggc ggtgcgtggg       60

tcccagtctg cagttaaggg ggcaggagtg gcgctgctca cctctggtgc caaagggcgg      120

cgcagcggct gccgagctcg gccctggagg cggcgagaac atggtgcgca ggttcttggt      180

gaccctccgg attcggcgcg cgtgcggccc gccgcgagtg agggttttcg tggttcacat      240

cccgcggctc acgggggagt gggcagcgcc aggggcgccc gccgctgtgg ccctcgtgct      300

gatgctactg aggagccagc gtctagggca gcagccgctt cctagaagac caggtaggaa      360

aggccctcga aaagtccggg gcgcattcgg cacttgtttt gtttggtgtg atttcgtaaa      420

cagataattc gtctctagcc caggctagga ggaggaggag ataaccgccg gtggaggctt      480

ccccattcgg gttacaacga cttagacatg tggttctcgc agtaccattg aacctggacc      540

tcccttcaca cagcccctca atcgtgggaa actgaggcga acagagcttc taaacccacc      600

tcagaagtca gtgagtcccg aatatcctgg gtgggaatga ctaagacaca cacacacaca      660

cacacacaca cacacacaca cacacacaca cagtaggaaa ggtgtatttc aagcacactt      720

tctttctcct tggggagaat tattgctaac catctaagtt ttctggaggc ggcctttttt      780

ctccccagcc tcccggcggg gtcaccctct cccaccttcc aggagagtgg aggacccgtg      840

agatacgggg cacgcaggca gcgacttcct gaaatgctaa caaggatcgt aggatcagtt      900

actgctgcga ggagcaagca cttgcttctt gggggagttt tgcagccaac agggaaatgg      960

gctttctttg tgagttagag gtagaggtcc ggcggcctga gtgattgaaa ctgctcggga     1020

caatgctcgt atgtttagca aacgacagaa ctgtagaact gttcctgaga aatcccaact     1080

gatagtattt tagtcatctc agacgacagt tagcacagtt taaaaatgag gcctacttct     1140

tgaaaaacag aatccaaggt agttttgtcc tcacattgac aaatgttgac acagccagtg     1200

taatttccta taaccaggaa aactgaaaga atatatgtac agttaaaata tgtacaatgc     1260

taattaaaac ttgtgtaata agtctaaaag taatttaatg aggcttcact tttatgaccg     1320

tccttgtggt atgcttcgcc aggaatatat agcttcaaaa agcaaaggcc agcggagggg     1380

taattatttt tttactgcaa tgttaattgt ctctttgaca tggaaatata aacctgttaa     1440

aactatcagt gtttaattta gtgtctcaat ttctattagc aaaaatttat aatctatagg     1500

ataaatgcac attttatttt ttacttttca tattatgcaa gttaattttt ttaatttagt     1560

caaaggagct tataaaggat ttcagggcct gttgctggat ttgattttaa ttcattttga     1620

aacattgaca agaccctggt tgttgttttt tttaacagtg gtttatccgt atcagcaaaa     1680

gtttagccac tgtgaccggt aactgtatga atatagttct taatattatt gtctatataa     1740

aaatatttat tactctagtt aatattattc tatataaaat cattttgttt aaattattaa     1800

gttgcctctg aaaatctgta gtaacaaagt agaacatgtc aatgtatata aatgccataa     1860

ttatgtattt tttagtttag gcctataaaa cataacattg tggtgatttt aagttagaga     1920

aaatatttta tagtatgtta atgtatatgc atgaaatgca aaaatattta aatgataggt     1980

tcattgaaat agatcatttt ttgttattta ggtataaatc aattttcagg acgtatgtga     2040

aaagcgcaat cttcaggaag tttctcaaga tagaacacag cttggataga atgtcttgaa     2100

atatatgcaa ttttccaatt tcatatgtaa aatgatatac ataatataaa atctagcggt     2160

gttaattata atgatatgta attatatatt tcacattaat atattttatg cccatggcta     2220

tattgatttg ggaatatata tggatactaa ttatgttagg attcatacaa ttccttgaga     2280

ggcacaagtg ctaaaaatta cttgtatgaa ttatttaata tcattgcaaa taagatgtta     2340

ttttaacttt ttttaagttt ctgcaaatat gtttattatg actttttatt tttatatgat     2400

tggaaataca tatactaaaa ttccacgtta ccagtttctt aaccacagaa acctgaaaaa     2460

ttgccatagt tgatttgtta cttctacctt ggtgcattta caaaatagtc atatttttat     2520

tatgaagtta aatattcatt tgtttatagc tacttcagaa ggctcaggtt atttttttct     2580

ttaatagcac agagtcctct caaggtaagc actgtgcagt tagtataaac cattattccc     2640

catgtgtaca tgattcacag tttgtattgt gttccaagtg aaccatagcc ctttcagaaa     2700

tcaagactta tattcatttt acttctttga gtactcttga attttagaaa gtccattatg     2760

atcctaaggt agcaacaaca tagcctatta ccgtctatga tggtttacag atctattatt     2820

ccacgttagt tcatcactat caactaccat gatagagtta agctaaacca ttttcccaac     2880

atatgaaaaa ctcctattac taaagtgata caaatggtat caaaaatact tttttatagc     2940

aaggttcaac agtgggccca gtgcttttac actttttcaa aagtccttgg agaaacagag     3000

aaaatctcac ttgccttctg tactaaaaca ttctaggccg aactaaaact gaaacttcat     3060

agtagaacac tgtaggccag gggtgttcaa tcttttacct tccctgggcc acataggaag     3120

aagaagaatt gtcttgggac acacattaaa tacactaaca ctaacaatag ctgatgagct     3180

taaaaaaaaa aaaaaactca tgatacttta agaaagtgta tgaatttgtg ttgggcagca     3240

ttcaaaacca tcctgggctg catgtgaccc tcgggcccac aggttggaca agcttgccct     3300

agctcctcca tctgctgcaa agcccagcct gatacaaaaa ccaacgtgat aaaaagtttt     3360

tgtggtgctt tattttggca gtttaagtta tataaacaat gggtacagtt tcattttcta     3420

aatataaaat ttttacattg aatatgaatt tttaagacaa attatctgaa ttctgattct     3480

catataccta actactaata tcttctctat ttgttgccca atgagattaa tccacctctt     3540

aaacacttca ccatcaagaa aaacaatttt gtattttaaa atgaacccat ccactttcat     3600

tcagctattt tatattcagg catcatccta aggaaagaaa ggttctgaca aagattaata     3660

cagatggata agtagtagca agaaatcaaa aactgcataa aattctagca ataaagtgtt     3720

aaattatggt acagttacat tctggatcat caggtatctg aagaatattt catagactgt     3780

taaatgattg cattataaag tcaggttttt ttaaagcaag attccaaaca gtaaacagtt     3840

tctctctctc tctctctctc tctctctctc tctctctctc accaaattag ttataatggt     3900

ttccgcagga tgagaggggt tgggaaaaag tttggtgata tttattttct tcgtttcact     3960

tttgagtttt ccaaagtgct atgaccatca tcagtaaaat atacatttcc aaagcctttg     4020

acacacggta acagtcctac acagtggatg aactaagagc ttctctaccc ttagatgggt     4080

agggagggag gaaagacaag gaaactgagt tgtttaagtg tcatacacga gaacgtggct     4140

ttaaggtctg ggaaaacctg cgagggctgt gacgtcagac tgtgaaatgc acgctatgtc     4200

cattcaccaa gacgttccat tttaaaaccc ataaatccgt agctatacct gtttccaagg     4260

tgcctcgtgt taggcctctg gtcacagcac ttggcgccct tcttgggatc tcttctctcc     4320

gcccccacta ccccacccca caagcacact ctagtcccct ccaatcaatt tcaggcaggt     4380

ctcgccgcct ccggagccac gctgggggtg caagggccct ggacccgaaa gagcgcccgc     4440

ccggcgacaa gagatgagat gcacgctgct cctccactcc tcagccccca ccatcctcct     4500

cctggatcct aacttcccca ctctctcaat tcctagagac gctgcggatc ccagaggctt     4560

aactggcagc tggaacgagg tcctccaaca agaatttaga cgctaggtcc aattatcact     4620

ccaccgcgcg cactttccgc aggagcgatg tgatccgtta tcataactgc ggacctgggg     4680

ttccacgtgg aagacgattg ggatttcact ggccgcggtg ggggtgggag cagacagagt     4740

ctgagtgggg ttagtggact cgagacgaaa ggcaggacat gacagaaggc aactctgggt     4800

cacctctcca gcttggaact ggctaggcct tgttttggag gggatgggta gatgaaaagt     4860

gagtcagggt tacccggagg aaccacgggg aaagtgcgct tctgagactc ttgacagcca     4920

tttcgttccc ttccaagcca gatggagacc caagagtgtt gaaaggccac gacttccctc     4980

agtttctcca tctgggggtg caggatggta tagagagtgg cccgtagtat ttttccagtg     5040

acgatgtctc tccattgttt tcttcttata ttgcagcttt ccccatgttt gaaaattttc     5100

ttttcaaatg aaatcattga ttagaataaa aaaaagtaag tagctattaa aacaagatca     5160

atttccatga cagtaagcca accgatggag aaaaccttgg gaattaataa atgaaggatt     5220

tgtttggtag atgataaaag gtccttttaa agggtctgac tcttcctaga aaaacccacc     5280

aacttgggac cgcaacagat ttaccatatc ctaattcatg ctattttaat gtgtattcag     5340

caaacccaca tgtgtttaca attgtcgaag ctaccaaatg tcaatagcgt tttttttcta     5400

tttgttgaat gtgaatctct tgtacgaagc catataaaca gaagaaatta caggaatgat     5460

tttaaatcac atacaaaacc aatagtattg ctagaggaga gttagtcaag gacggcatta     5520

tgaagaaagt gagggagaat ttccaaagag cagaacgata gggcttggtg gaccaaagaa     5580

cgtttccatc taaagggaat ggcaaatact tagagtctct gaacccactg aatcttggac     5640

tatttaacta atatttgtag ttccagatat agcacagtgc cttgtacata gtggtatttt     5700

taaaaatata gtgcctcgta gatttttttt caacttttat ttaggaggag agggcacatg     5760

tgcaggttaa ttacaaaggt atattgcacc atgctgaggt ttcgagtacg actgaatctg     5820

tcactcaagt agtgagcaca gtacccacag taggtagtat ttcagccctc gctcattccc     5880

tttctcctcc atctagtagt ccccaatgtc tattgttctc atatttatgt ccaattagca     5940

tttgtttttt aaaaagggtg gttgaagaaa ttctcagtgc ttgtcagtgt ctctcagtgc     6000

attcatttaa ttcatgagcc ctggaatgat ggtttcattt gggcagaact ctacaatcaa     6060

aaagaagtaa taaaagggaa aaaaaagtga aagccatcaa ctacaggatt gaaattccca     6120

aagcatcaga ggtcctttca aaaaatagta tgttgatttt taatttttat gacttattgg     6180

ctttgttcat gaaaatataa acatgttatc acaaaggatt ttttaattca actatttctc     6240

agttttctct ttcaccttca aaataaaata tcataaatta tttaaatggt tgtgaaggca     6300

gtaggatttt tttaagagag aaaagtttta tagaggttca gaattacatg aacaaagaca     6360

tgtaatctct taagcaaatt gaaactaata aaatcgtaca atcaaggtaa cgtaaataaa     6420

aaagcctctg ctttcttaat tgaattatgt gagtaactag aaattttaaa agtatggcaa     6480

aggttaacaa cagcattatt acctgggctg cctttaaaaa tacatatttc tggggttcac     6540

gttcagaaaa tttgattcag atttgctgtg ggtcccagaa atctgcattt taaataaaca     6600

cttgaaggag atactaatac aagtggccca ttgggacaca atttgacaaa tatgaccaat     6660

tttacttttt aaaccttatt tctgcttctt tatctttgaa ttgaggtcca ggattttagg     6720

taagatttta agtttagagt cagtttactg gatcccaggg aggagagtct gagtaatcag     6780

tggaggagtt atttcaccaa atgaaggaga ccctttatta ttatgtgacc ctttgtatga     6840

attggaaaag aatgtcttgt agataccaca tttttacagt cagaacatag tttgagagaa     6900

aaaaatataa caagatatat ttgtgtttta aagcttacag aaccagacag aaaatttcca     6960

cataagctat ataagatacg ttgtcttttt aaaacactat atacacttct ttctgttcgt     7020

gcaggatgaa tggatctctc tctctctctc tctctctctg tgtgtgtgtg tgtgtgtgtg     7080

tgtgtgtgtg tgtgttgtaa taaggggttt ctttcatttt atgatccaga ccaggctcgt     7140

aataaacatg acaacctaaa attatgtaaa aaagaaaaat caaagcacaa gtgtttcaca     7200

ggtttaactt atgcttatct aagatcaggg caagattgca ggaaaatgta gccataacag     7260

aataaagcat ttatggacaa aatgatgggt ctttatgtct ctgtaaaagc acagtgatgg     7320

ggggggaaat atagatgaaa aatgtaagct aaaaagtaac aattataaga aaaactaaaa     7380

tatcatgcct ttcaaatgat catttttctg cttttaagct aaaatttgtc taatattaca     7440

ccagtgactt tgctgatgta ttaggaaaaa gcttgttttg ctttcttttc tcgagtgcca     7500

ccattttctt gctctcattc tctttcaggc tgccagatca tctgactcag caattgtata     7560

actctctcac ccaatttaaa gaaacagcag ctgtctagag aacaatgact cccccagttg     7620

aacatctaat tgttaaatgt ccaacatcgg acactttgaa ttttactcca tgcaatttac     7680

atgctgaata gttgaagttg aatatattat atttaacatt taatttttaa aagcttattg     7740

aaactttctt cctaaatcac atggtaaagt tattgttttc ttcaaaaaca attaggagga     7800

gcttaacaat aataggacac ttcaacttcc attatctaat ttaattatca caatatcctt     7860

atgttttcaa tgtttcattt tttcattttg tagatctgga gactgaggct cagataggtt     7920

gcatggccta ccaaaagtca ttgactagta attcatatat agttgaactt ggttgcccat     7980

ggagtgctat aaatatgtat atggtttcag ttccatctct tttagttaac tattattttg     8040

aaagtcgctt aacccctttg ggcctctact atactcaagc atcagccgta taagtcacag     8100

taaatattta ttggttgaaa ggaggttaac atctttcaaa aatttatttt ttgaccaaaa     8160

taaaaccagt gaaaaattct catatgactg tacatataaa ttacttattc ctaccttaat     8220

ttaaaagcaa taagtgggat acctattcac cagcacagga accacttgaa gcgtgcagtt     8280

gaaagattac tttctttagc attcacatga cctgtgagca gattctattt cttttgctta     8340

ttagctgtca tggtaccaga atgaagtatg agaaactctc agtgctttca tgttctcatc     8400

tgtaaacctg agaccctatg gtagtcccgt aataagaggt agataaaata gtatgtgtga     8460

agagtcactg taaactttta cacagtgtac gtttgtcagt tattatagtg cctaattaaa     8520

ctatgccctt aagaaagcac attagttttt tacagtaaat acctacttca ttataatttt     8580

tcagtgtagc tagaaatttc taaactccac tttaaaaata tacatatcat aataaaaata     8640

tatttatgta ttcagactcc tggtatgttc caaggtgtta ggtaaaatca gtgtaaattt     8700

gcatactttt aaattcacat ctgtacagaa gatctatatg gtggccttta gggtatacct     8760

ctaagctatt ctagtattca taatcattaa agagatatta agcagtgttt gtgaacccct     8820

gttttctaag acaggaaatc aaggtagctt tagaaaactg gaaaaaaagt tattagtcta     8880

tctatctaat aacccagaat aataatttcc aaaggaatca ctgaagataa ctggattttt     8940

aattccttca gaatggttgt cacagtctga atatctgaat caacagtttt gaccaaaaca     9000

attttctaaa aattctttag tataaaaaat tatgtgtgtg tgtgtctgtg tgatgaaagg     9060

aatgataggc agaaacatta ctgtcatcct tacgacattc aaaatgccta ccttggaggg     9120

tgaccttcag ttatttttat gcaaatgtga agaagttatt tagaagtagg atatcaaaga     9180

gtaacacaaa atacactaaa tagtatgctt tcttaaggct aaattgactt gggggtttta     9240

aatcagtaca gagtaaacat acagtatatt ctgttatcat tgcctttttg aaaaattaat     9300

tatggaagtt atcatcttaa ccgtaacaac acaaaagata aaactctacc ctcaacccag     9360

agactcaaag gaaaacatga gtggaaatgt taaatctgta tgtgaaaagt gctaaaacat     9420

gaataggaag cagttactta tttaatcaaa gttgattata tttcatcaag aagttgattc     9480

ccttgagtgg agttgaatca catatcaggt gaagaatgtg atttggggaa gaatggtcta     9540

acacaagaaa attttcttgc aatctttaat aatatcagag gggagattgg cttcagaact     9600

ctcctaagtt caggaaagga cacagaaaat tgaacataac agtaagacta tagagtccca     9660

agaaagcaag ctacttttaa aggatagttt tttagagggg caaaaggggg acaaccattc     9720

tccatttgat gagaaaagct tccatgtaga tggtgcccct gaaattagag tatcctaaac     9780

cagtgttaaa cctatcagtg aaacatgaat attaaacctc cactcccagt agtgaaaacc     9840

gaatacatta ttatttatct gtgactttca acattatctc agaactctaa cagcacatgc     9900

gtacatcagc agcataagca gaaatgagat attatatatg cttgtgttag caattaaaaa     9960

ggacagcata tttgagaggg gaaaatctgt cctatcaaga atgaaaaaga gggaggttag    10020

gaaaagtagt ttagagaaag taaattttgc aattcctcag ttttaactgt agtttctcca    10080

ttgtaccttc cacttgaaat gcactccaag cagtggaggt gggtagcaat gaatgcagag    10140

gaaacactga acacagtgac actctccagt gtcacttctc atgatttaat gaggggtttt    10200

ttttggaaat tcttctgtca taacatggga aactttgtta caaagaagct gttttttcag    10260

agggttagaa ttcagaggta gcatcatacc ttttagaaga gaatttgctt gttgaaacca    10320

cagatacctg ctagaatgta caggaattaa tgaaaaatta ctcaaaagga catttatttt    10380

gatgacctaa atgaataact tcatagtaaa tgtcatatat attctcaaaa aattaaaaag    10440

caccatttat tgagagccta ccgtgcaccc ggatttttat atatctgaca ttctttattc    10500

ctcacagtaa ccttatgggg taaattttat tttccccact ttgtgaggtg aggaaataaa    10560

ggctcagaaa gtttacataa cttattcaag cccacagagc tggtaaatga gaggtcagtt    10620

ctatctgagt ttaaagacta ggcttgtccc acttgcatat gtgtcatttc caaaattatg    10680

attaaggata tggttggcat ttcccgccac ccacattaag tccaattaag tagctgtggc    10740

catagaaaga atggagaatg gagagaggaa ctgacttcaa cagctacagc aaacatttat    10800

tagctgagta accatagcta catagttcct caatatgtac cactcctcca ttttgttatc    10860

tataaatcaa aatggtggct ttttaaaaag cagttttaca atatattcaa gagccttcta    10920

ccctttgaaa aactgcaata ctatttttag tagcaattag aaacacctta aatatctgac    10980

aacagggaca tcattaagta aattataact ttttccagtg ggatgtgtta cagctgttaa    11040

aagtagcatt tatgaagtgt ttttggagaa gtttggaaaa tgctgtaata agttagaaaa    11100

agctcatttc aaaattgcat aatattcaca atgtaaagat taagcaaaga aaaaggaaga    11160

agtatttcaa aatgttaata attattgctt tgtgtggggt agtttttcat tttctatgtg    11220

cagctaattc cttaattatt tttaaatatg tgagctttaa tcaggaaagc aaatcattca    11280

aaaatgaggg gactgaatta agtgactttc aggggacttt gcgtgtcttt gagttccaaa    11340

tttctatcac tatgtattac tactgaagaa taatcataga agcacagtag tttctgaaaa    11400

tggagagtca gtaatcttgg cccaggtttt gcaacttgct ctaaagcaga gtcctcaaag    11460

aaaaggaagc attgatgagt tgtccacaat gtactggata aattatcatt aggaaaacat    11520

attgtagtag ggagagtgag gacctctcaa acagaactga gaaccttaag tttgaacttt    11580

tcttttcctt attacttaag cactctgagc tttttttttt gtctgcatta tgaagaaaga    11640

ataatactct ctatcccatg ggacagctgt ggaattataa attacacata taaaactgct    11700

tgatgcttgt cacatagctg ggggttgaaa aaatgatagc cattattttc ttggcaactt    11760

ttaatgaatt ttttattatc tctatttctt tctgcctatc tcctctaatt atgtttatta    11820

cttattttgt tcctcaggat gaggtcaatt ctcaatatct gtgctgtaca taatatacat    11880

atataccaaa tatgtgcata tagtatgtac atacatacat actgtgctaa tcttttagtg    11940

ttctcagctg atcaaatagc tacaaataga tataagtaat tcgccacaag taatttatca    12000

acataaaaaa aatttacaaa aaagttaagg aataattgtc tccatgagct gcaaagatcc    12060

ctcatttcac aagagtacac cctagagata ttttaatagt aaatttctca catagattta    12120

aaatcacatt tgttttgcac ataatttaga aaagatacct gctatataat aagtaatata    12180

cttttaagtt tccttcaaaa tattcttggg aagatgataa taggtactgc taattctata    12240

cccagttaac attttggaaa ctaaggttga aaattgtgac ttaactataa ttatgcatta    12300

aatctacaac acatcaaaga attttgcatt ttgtactcct tactaagatc cagtttgagt    12360

aggaagataa attttacagt aattctgaat gagggaagtt ggcacagagt ttctaaaaga    12420

gtaccttcct tatagcaaat actaaataat tgtgctatat tgaatttaat taaatagaga    12480

atagtaaaag ggagaaagaa acatccaatg ttttgaaact tctagagatc tactcccagg    12540

gacacattgt tttttcttag caaatctgtt tggaggtctg ctctactttc tcagaggtct    12600

ccctttcatg ctgaagctat cttttttcct tgtggaacat aagtaattaa ataccttgca    12660

attatttacc taagaaagtg tttctttccc gtttaaaatg ctcttaccac ccacattgga    12720

ctcgattatc agaattttta tccggggcag cttcaggagc actttggcac ttcggggcta    12780

aaccacaatc tgtttttaca tgtttgtgat tatacccgtt ttgtagatca agacattgaa    12840

gctagtaaaa aaaaaaaaaa gtcatttttt cagggtaaca aagtaggtgg tagaactagg    12900

acagggactc taatttcctt acattattgc ttttctaaat taaagggatg catggaatta    12960

ttcctccatt gcctttgcct tcaaataatt atctattgca cccaacatcc tattctagaa    13020

ctcatctatg aaggcttaac acagctgtac ctgggagctc cattacaggg catatatctc    13080

gctctcataa gctacttcct aaggaattct ctttaattat gggagctttt ccagactctg    13140

aaatcttttt ttcctggtaa cacaagtgtg aggtgtcatt tatcagaatg catcacccca    13200

gtcttccctc ctcaaatgat tactgtaggc tccactcaag agctcatccc agttcaagac    13260

caccttcctc ctccagagaa gcaaatatat atatacacgt atatatatat atacacgtat    13320

atatatatat acacgtatat atatatatac acgtatatat atatatacac gtatatatat    13380

atatacacgt atatatatac acgtatatat atatatacac gtatatatat atacacgtat    13440

atatatatat acacgtatat atatatacac gtatatatat atatacacgt atatatatat    13500

acgtgtatat atatatatac attttttttt tttgagacgg agtctcgctc tgttgcccag    13560

gctggagtgc agtggcgcga tctcggctca ctgcaagctc cgccccccgg gttcacgcca    13620

ttctccttcc tcagcctccg gagtagctgg gactacaggt gcccgccacc tcgcctggct    13680

aattttttgt atctttagta gagatggggt ttcaccgtgt tacctaggat ggtctagatc    13740

tcctgacctc gtgatccgcc cgcctcggcc tcccaaagtg ctgggattac aggcgtgagc    13800

caccgcgcct ggcagagaag caaatatatt gatggttgtt accaatacat gctcttgact    13860

aagaaacctt ctttcttaat taatattgac aactttaagc cgagtgcctg acatatatta    13920

ggtactcagt tactcttttt caactaaagt tatgaatgat gattctaata aaagtaactt    13980

atttgtctac tagttttatt atgtttattt aattcattag aaaggccatg gacatagtac    14040

aaaattcaaa caatataaat catggaatgt gaaaagtaag tcacatgccc atcccagttc    14100

ttcatttcct tacctcacag gtaacagctt ttcctgtatc tccccagaga tattctatgt    14160

atattttgtt tttaacacca agctatattt aaaacaatta tctttaataa taatgttaat    14220

attgaaactg gtaaagaaat atgtgtgtat tatctcacct caagcgtaaa caatagaaca    14280

agagagagcc cattttgaaa attatggaca atgaatctag aaataatctc aaaagatttt    14340

gcagtcaaaa aatagttcat tagatacatg agaactgtca cttggtctca gtgtagagct    14400

attgcctcaa ctccctttat tttcctaaca aaatcatctt gcttatccca tgaaatacgt    14460

gcatattgcc aatcctacaa tgccgcatca gaaccagaac ccaactctgg aacactacct    14520

tctcaagtat ctttctgtct ctttatggta atatgttgaa ttaatattca catctattat    14580

gactagtctt tgatttgtag ggttgctgaa gtagtagcac cactgcaggg ctttctttag    14640

tttaaagaaa gtaatcaggt gtccctactg tgtcatgatc tccaccctca gctgggttct    14700

ccagtctggt tttaaagaac aaaacaaaag gcttctctgt ctgagtctta ctcaacccat    14760

cctctctact cataagaggt attccaaacc tttacgattc tcaaacttcc taaccgacca    14820

tcttattttc actctgcaaa caagctaacc tcctcattca tagaaggaag tgcctcaact    14880

tcctccccgt tctgaccttt tctccctccc aaatctatgt atctcttgtg acaaaatcta    14940

taaccaccgc tgtactttga gttctatttc ttcattattt ttgagggacc tcaagtcctc    15000

aaaaatatcc tatcttgcct gtgtacttaa cttttctttt attcttttct aactttccct    15060

tctcttcact tggcacttgc ccttccaggt atatgtgtgc tcaggtctcc tccaccttcc    15120

atctgcctca cttcatggca tagggccttg aactatcaca accaagctat gaaagagtag    15180

tcaacgcagt gtccccactt ccttgccatc ccattatcct agtttttctt ttggctctct    15240

gaggagtcct tcacaggctg gttttcagga ataagtctaa atgaatcact ttcagttttc    15300

ctaaacttct atgcctttgc acatcctctt acctctgcct agaatatctt tctccttctt    15360

ttccatcttt aaactctcac atcattcttc aagactggga tcagctctca gcatccggaa    15420

gcctttgcct actagagaca aatgagaatg agtttggtca ccttttcatt ttcttgtatc    15480

attctgtgct ttattttgct cttctaagag cgttacatgc ttcatttaat ccctaaacaa    15540

ctgtttgagg caagtacagt tattatccta atcatgcaaa tgagaaaaca gaggcccaga    15600

catgttgagt aactttgata aaagttaaag aaccaataag tggaacagtt gaggtttgaa    15660

ccctggcagt ctgactgtag agatactatg tttgacctac tcccctctgc ccccacccca    15720

tgtctgccct tagtttctga gcttgttgaa tgaatgaaca ggtggtagtc tttttttgtt    15780

ataagactga tcagaattaa gacaggttta aatttcacgt gtagaatttt caaaactgca    15840

aaggcagtgc aaatctaaaa aaagaatggc attctcagga aagaggaaaa gtaagtgtga    15900

gaataataat aacaataacc aacaaacttt agtaaattta gtaaatgtag taaattttta    15960

cattaaaagc ttttggacat acattatcat attttatggc cacatgaaat atattataat    16020

cccattttgc acataggaaa tctgagactg gcataaggag cacagagatc caggacttta    16080

tattttcatt cttctaggat tttgcacctc aggtcgatat gtatgagtaa actgggagta    16140

taatgggctc tttaacagaa aaactaggaa agttttccca ctattattaa ttatttacat    16200

aatatttttt taattttatt attatttata ctttaagttt tagagtacat gtgcacaatg    16260

tgcaggtttg ttacatatgt atacatgtgc catgttggtg tgctgcaccc atcaactcat    16320

catttagcat taggtatatc tcctaatgct atccctcccc cctcccccct acataagatt    16380

tataatggat aatggacttc aatttctaga gcaaaatggc cccacccaag gatgccataa    16440

tccttccaga gctctactgc aagatatgag atatacatat ctaaaacttg ttcttggtat    16500

ttccaaagca gtcaactttt acacctgttt ataatgcatc caaatgttgt ttttatatgg    16560

ttgcatctcc catcttcttc accaatagct atatatattt ttcacaagag ctgaaagagt    16620

tcttgatgta ggaatccatg gtagagtttc agagaaatcc ctgaattcac tgaaagtttt    16680

atctagaaat acatgtgcaa gtgaacacat cttttttaaa aaaaatcatt acctactttc    16740

ttttttgaga agaaggtatt tatttcaaca gactcttgaa ggagcctact cttcccactc    16800

tcccaccccc attaagaacc actgtaggcc gggcacgatg gctcatgcct gtaatcccag    16860

cactttggga ggctaaggtg ggtggatcac ctgaggtcag gagttcgaga caagcctagc    16920

caacatagtg aaaccccgtc tctactaata atacaaaaat tagctgggta tggcagcatg    16980

tgcctgtaat cccagctact cgggaggctg aggcaggaga attgctcgaa cccgggaggc    17040

ggaggttgca gtgaaccgag agagatcgtg cggtgccatt tcactccagc ctgggcaaca    17100

gagcgaaact ccatctcaaa aaaacacaca aaacaaacaa acaaaaagaa agaaccattg    17160

tattagtgat ggaaatgtgt tccctccctc ccatcctggc aaccactttc ttcctcctcc    17220

atcataaaat atcttaaact aaactaaaat aattttattt atcgatagtt tgaattttcc    17280

ctatcattgc tacacagcta attgagaggt accccgagga aaatataaat ggtacagtaa    17340

tgcattgtag attttaataa catacttgac atcccaaatt gttttcattg gcttcatttt    17400

aaaaactaca tgttttaaaa tcaagcagac actaaaagta caagatatac tgggtctaca    17460

aggtttaagt caaccaggga ttgaaatata acttttaaac agagctggat tatccagtag    17520

gcagattaag catgtgctta aggcatcagc aaagtctgag caatccattt tttaaaacgt    17580

agtacatgtt tttgataagc ttaaaaagta gtagtcacag gaaaaattag aacttttacc    17640

tccttgcgct tgttatactc tttagtgctg tttaactttt ctttgtaagt gagggtggtg    17700

gagggtgccc ataatctttt cagggagtaa gttcttcttg gtctttcttt ctttctttct    17760

ttcttttttt cttgagacca agtttcgctc ttgtctccca ggctggagtg caatggcgcg    17820

atctcggctc actgcaacct ccgccttctc ctgggttcaa gcgattctcc tacatcagcc    17880

tccgagtagc tgggattaca ggcatgcgcc accaagcccc gctaattttg tattttttag    17940

tagagacagg gtttcgccat gttggtcagg cttgtctcga actcctggcc tcaggtgatc    18000

cgcctgtctc ggcctcccag aatgctggga ttatagacgt gagccaccgc atccggactt    18060

tccttttatg taatagtgat aattctatcc aaagcatttt tttttttttt tttgagtcgg    18120

agtctcattc tgtcacccag gctggagggt ggtggcgcga tctcggctta ctgcaacctc    18180

tgcctcccgg gttcaagcga ttctcctgcc tcagcctcct gagtagctgg aattacacac    18240

gtgcgccacc atggccagct aatttttgta tttttagtag agacggggtg tcaccatttt    18300

ggccaagctg gcctcgaact cctgacctca ggtgatctgc ccgcctcggc ttcccaaagt    18360

gctgggatta caggtgtgag ccaccgcgtc ctgctccaaa gcattttctt tctatgcctc    18420

aaaacaagat tgcaagccag tcctcaaagc ggataattca agagctaaca ggtattagct    18480

taggatgtgt ggcactgttc ttaaggctta tatgtattaa tacatcattt aaactcacaa    18540

caacccctat aaagcagggg gcactcatat tcccttcccc ctttataatt acgaaaaatg    18600

caaggtattt tcagtaggaa agagaaatgt gagaagtgtg aaggagacag gacagtattt    18660

gaagctggtc tttggatcac tgtgcaactc tgcttctaga acactgagca ctttttctgg    18720

tctaggaatt atgactttga gaatggagtc cgtccttcca atgactccct ccccattttc    18780

ctatctgcct acaggcagaa ttctcccccg tccgtattaa ataaacctca tcttttcaga    18840

gtctgctctt ataccaggca atgtacacgt ctgagaaacc cttgccccag acagccgttt    18900

tacacgcagg aggggaaggg gaggggaagg agagagcagt ccgactctcc aaaaggaatc    18960

ctttgaacta gggtttctga cttagtgaac cccgcgctcc tgaaaatcaa gggttgaggg    19020

ggtaggggga cactttctag tcgtacaggt gatttcgatt ctcggtgggg ctctcacaac    19080

taggaaagaa tagttttgct ttttcttatg attaaaagaa gaagccatac tttccctatg    19140

acaccaaaca ccccgattca atttggcagt taggaaggtt gtatcgcgga ggaaggaaac    19200

ggggcggggg cggatttctt tttaacagag tgaacgcact caaacacgcc tttgctggca    19260

ggcgggggag cgcggctggg agcagggagg ccggagggcg gtgtgggggg caggtgggga    19320

ggagcccagt cctccttcct tgccaacgct ggctctggcg agggctgctt ccggctggtg    19380

cccccggggg agacccaacc tggggcgact tcaggggtgc cacattcgct aagtgctcgg    19440

agttaatagc acctcctccg agcactcgct cacggcgtcc ccttgcctgg aaagataccg    19500

cggtccctcc agaggatttg agggacaggg tcggaggggg ctcttccgcc agcaccggag    19560

gaagaaagag gaggggctgg ctggtcacca gagggtgggg cggaccgcgt gcgctcggcg    19620

gctgcggaga gggggagagc aggcagcggg cggcggggag cagcatggag ccggcggcgg    19680

ggagcagcat ggagccttcg gctgactggc tggccacggc cgcggcccgg ggtcgggtag    19740

aggaggtgcg ggcgctgctg gaggcggggg cgctgcccaa cgcaccgaat agttacggtc    19800

ggaggccgat ccaggtgggt agagggtctg cagcgggagc aggggatggc gggcgactct    19860

ggaggacgaa gtttgcaggg gaattggaat caggtagcgc ttcgattctc cggaaaaagg    19920

ggaggcttcc tggggagttt tcagaagggg tttgtaatca cagacctcct cctggcgacg    19980

ccctgggggc ttgggaagcc aaggaagagg aatgaggagc cacgcgcgta cagatctctc    20040

gaatgctgag aagatctgaa ggggggaaca tatttgtatt agatggaagt atgctcttta    20100

tcagatacaa aatttacgaa cgtttgggat aaaaagggag tcttaaagaa atgtaagatg    20160

tgctgggact acttagcctc caattcacag atacctggat ggagcttatc tttcttacta    20220

ggagggatta tcagtggaaa tctgtggtgt atgttggaat aaatatcgaa tataaatttt    20280

gatcgaaatt attcagaagc ggccgggcgc ggtgcctcac gccttgtaat cccttcactt    20340

tgggagatca aggcgggggg aatcacctga ggtcgggagt tcgagaccag cctggccaac    20400

aggtgaaacc tcgcctctac taaaaataca aaaagtagcc gggggtggtg gcaggcgcct    20460

gtaatcccag ctactcggga ggttgaggca ggagaatcgc ttgaacccgg gaggctgagg    20520

ttgtagtgaa cagcgagatg gagccacttc actccagcct gggtgacaga gtgagacttt    20580

gtcgaaagaa agaaagagag aaagagagag agaaaaatta ttcagaagca actacatatt    20640

gtgtttattt ttaactgagt agggcaaata aatatatgtt tgctgtagga acttaggaaa    20700

taatgagcca cattcatgtg atcattccag aggtaatatg tagttaccat tttgggaata    20760

tctgctaaca tttttgctct tttactatct ttagcttact tgatatagtt tatttgtgat    20820

aagagttttc aattcctcat ttttgaacag aggtgtttct cctctcccta ctcctgtttt    20880

gtgagggagt taggggagga tttaaaagta attaatacat gggtaactta gcatctctaa    20940

aattttgcca acagcttgaa cccgggagtt tggctttgta gtcctacaat atcttagaag    21000

agaccttatt tgtttaaaaa caaaaaggaa aaagaaaagt ggatagtttt gacaattttt    21060

aatggagacg ggagaagaac atgtagaaaa ggggaaatga tgttggctta gaatcctaac    21120

tacattggtg tttaatatag gaacatttat ttatataaca ttttaaagta ctaaattcat    21180

attagtatat tatcaaatgg atatattatc aaatgggttt aagcatccta cacattttaa    21240

ttcaattgat tcattttctt tttgctttgg atttctatca tgatttaaat atttacatat    21300

gggttacttt ttagattttt catactatga aatataagaa aaacctttaa ggctagtttt    21360

atgaccaaga cgaaggactt cattgaatac acaaaacaat aaatatactg caacattttg    21420

tctttctttt tgtagctgca atttggtttg cttatacttt ctctttgtct ctttgaaaac    21480

tgagtcagtt tcactttctc aggacaggat ttaataacca taatataatt tagtataatt    21540

ccttgattta ggcaaattat gcaatttgtg tttagtatga aatgtaccta aaaataagta    21600

actcctcttt aacaccacca tcctcaaact aatataacaa ataacagtta tcctaaaata    21660

aattgtctac ttccaccatg cagcactcaa attttaaggt tgctatgact gcagacagta    21720

ttttaaaatt cctctctgga aatggctttg tttccaagat gatttaggaa ccaaagaggt    21780

gaccatctct tgtttaatga actctcaaat cataaacctg ggaagtgttt tagtttccta    21840

ctgctgctgt tacaaattat cacaaatgtg ttagctaaaa caaacacaaa attattattt    21900

tacagttcta gagatcagaa gtcaaaaatg ggtccacaag gtttcattcc ttttggaaac    21960

tctaaggggc aatctgtttc cttgtctttt ccagcttcta gtgaccatca aattccttgg    22020

ctcatggtct ctgtattttc tctgtggcct gtgcttccat tcttgtatct tctctctgac    22080

tgtgaccctc taataaaaac acttggggtt atgttgggcc caccctgaaa attctggata    22140

atctccctca agaccattaa ttaaatcaca tctgcaaagc ctcttttgcc acataagtta    22200

atgtattaaa agtttttgag gattaggaca tagacattgg gggtgggggg gcattattca    22260

gcctaccaca ggaaggaatt ttagggttaa ttaaactagc cttcttattt tatacttgaa    22320

gaaattgaag ttttggaatt ggagagcatt atgctaaatg aaataagcca aacacagaaa    22380

gacaaatatc acatgttctc acttatctgt gaaatataaa acaattacat tcttagcagt    22440

aaagagtaga atggtggtta ctagagctgg ggggtgggag gaatggggag atggtaatca    22500

agatataaag cctcagttaa gatgggagga ataagtttga ttgttttttt tgagatgtgt    22560

ttcatagcat gatgaatata gctaaatagt aaatcccaaa tgctctcatt tgacaaaaat    22620

gtcaaatatt tgagatgatg gataggttac ttagcttgac ttaataattc cccattgtgt    22680

tcaaagatca taacttcata ttgtaccaca taaatatata caactgtact atcccaatat    22740

ataattttaa aactaatata atgaaaaaga aattgaagtt caacattccc agaagctaag    22800

tgtaacttaa aagttttgtg agaatttgtt ttaacaaaca aacaagtttt ctctttttaa    22860

caattaccac attctgcgct tggatataca gcagtgaaca aaaaaaaaaa aaaaaatctc    22920

caggcctaac ataatttcag gaagaaattt cagtagttgt atctcagggg aaatacagga    22980

agttagcctg gagtaaaagt cagtctgtcc ctgccccttt gctattttgc ccgtgcctca    23040

cagtgctctc tgcctgtgac gacagctccg cagaagttcg gaggatataa tggaattcat    23100

tgtgtactga agaatggata gagaactcaa gaaggaaatt ggaaactgga agcaaatgta    23160

ggggtaatta gacacctggg gcttgtgtgg gggtctgctt ggcggtgagg gggctctaca    23220

caagcttcct ttccgtcatg ccggccccca ccctggctct gaccattctg ttctctctgg    23280

caggtcatga tgatgggcag cgcccgagtg gcggagctgc tgctgctcca cggcgcggag    23340

cccaactgcg ccgaccccgc cactctcacc cgacccgtgc acgacgctgc ccgggagggc    23400

ttcctggaca cgctggtggt gctgcaccgg gccggggcgc ggctggacgt gcgcgatgcc    23460

tggggccgtc tgcccgtgga cctggctgag gagctgggcc atcgcgatgt cgcacggtac    23520

ctgcgcgcgg ctgcgggggg caccagaggc agtaaccatg cccgcataga tgccgcggaa    23580

ggtccctcag gtgaggactg atgatctgag aatttgtacc ctgagagctt ccaaagctca    23640

gagcattcat tttccagcac agaaagttca gcccgggaga ccagtctccg gtcttgcctc    23700

agctcacgcg ccaatcggtg ggacggcctg agtctcccta tcgccctgcc ccgccagggc    23760

ggcaaatggg aaataatccc gaaatggact tgcgcacgtg aaagcccatt ttgtacatta    23820

tacttcccaa agcataccac cacccaaaca cctaccctct gctagttcaa ggcctagact    23880

gcggagcaat gaagactcaa gaggctagag gtctagtgcc ccctcttcct ccaaactagg    23940

gccagttgca tccacttacc aggtctgttt cctcatttgc ataccaagct ggctggacca    24000

acctcaggat ttccaaaccc aattgtgcgt ggcatcatct ggagatctct cgatctcggc    24060

tcttctgcac aactcaacta atctgaccct cctcagctaa tctgaccctc cgctttatgc    24120

ggtagagttt tccagagctg ccccaggggg ttctggggac atcaggacca agacttcgct    24180

gaccctggca gtctgtgcac cggagttggc tcctttccct cttaaacttg tgcaagagat    24240

cgctgagcga tgaaggtaga attatggtcc tccttgccct tgcctttcct ttttgtgatc    24300

tcaaagcatc ctccctccgc ccccattcca tggccccagt tccctactcc cacagctgtc    24360

tgctgaaact gccaacatta ctcaattgtt tctgggggga ggaacatttt tttttgaaac    24420

aaaatagata tatgaaacag tacacgggaa ttaacacgaa tatttaaggt aaaacatgac    24480

cttgaagatt atgaaatcca tcttattttg gcccagaacg ggggcattgg gctccttggg    24540

ccatagggga gctggggagg acagggtgaa gagttagctc taagccctct gcttggagat    24600

gctgtaaata cagaacgcaa aatcaccttc gaagttaaag acgcgaagtt cttctttact    24660

cggcccctcc tcccctcccc cccgccaatt ccctccagtt acagctagca tccaggtccc    24720

gggaggtgaa gaaggagact tcggctccag ttacagctag catccgggtc ccgatttaga    24780

aggagctgcc aattacagcg cggttccagg gctgagcaaa aagcctgagg agccaagtgg    24840

gagagggagt aaaactactg aattgggcca caagcaaatg aataaactga acgactctta    24900

accaaaccta atatatttaa tccaaacaca caagtctttc atttcttccc tcctcccttc    24960

cttctcttac tccccaacac cccctcttca agcacaatta attatatggt tagattctac    25020

tgcgtgatca gccctgttct aggtggtggg cacgccaagg tgaatgagac caaacaagag    25080

tcttgccctc atggggttta catttggaga cagagtcgat ctgttgccca acctggagtg    25140

cagtggcgcg atcacagctc actgcagcct caaactccct ggctcaaggg gttctcccac    25200

ctgagcctcc cgactagctg ggaccacagg tgcacgccac gacgcctggg tttgtttgtt    25260

tgtttaatag agacgaaggt ctcaccatgt tatctgggct caagcgatca tcccccctcc    25320

tcctcctaaa gtactgggat tacagtccca agctatcttg cccgacctgg gaaacagacg    25380

ttaaggaaga taacaatcta ttttcagaga gcgagtttat aaaaccaatg caatgggtaa    25440

atatgaagtg tgaataggag gagaagctaa agagtggtcg gagaatctaa tgcaagctac    25500

gggagaaaga aactcaagtg caaatgctgc ctcaggaata aacgtaaaaa gagactttca    25560

agtgcaaatg ctccctcagg aataaaataa tcttgagact ctcaagtgta aatgctgcct    25620

cgggagaacc gaacggcgag ctggagccca tacgcaacga gattagagag gaaggcagaa    25680

gccagagcac atgaataaat gagcatccat tttgtttcag aaatgatcgg aaaccatttg    25740

tgggtttgta gaagcaggca tgcgtaggga agctacggga ttccgccgag gagcgccaga    25800

gcctgaggcg ccctttggtt atcgcaagct ggctggctca ctccgcacca ggtgcaaaag    25860

atgcctgggg atgcgggaag ggaaaggcca catcttcacg ccttcgcgcc tggcattgtg    25920

agcaaccact gagactcatt atataacact cgttttcttc ttgcaaccct gcgggccgcg    25980

cggtcgcgct ttctctgccc tccgccgggt ggacctggag cgcttgagcg gtcggcgcgc    26040

ctggagcagc caggcgggca gtggactagc tgctggacca gggaggtgtg ggagagcggt    26100

ggcggcgggt acatgcacgt gaagccattg cgagaacttt atccataagt atttcaatgc    26160

cggtagggac ggcaagagag gagggcggga tgtgccacac atctttgacc tcaggtttct    26220

aacgcctgtt ttctttctgc cctctgcaga catccccgat tgaaagaacc agagaggctc    26280

tgagaaacct cgggaaactt agatcatcag tcaccgaagg tcctacaggg ccacaactgc    26340

ccccgccaca acccaccccg ctttcgtagt tttcatttag aaaatagagc ttttaaaaat    26400

gtcctgcctt ttaacgtaga tatatgcctt cccccactac cgtaaatgtc catttatatc    26460

attttttata tattcttata aaaatgtaaa aaagaaaaac accgcttctg ccttttcact    26520

gtgttggagt tttctggagt gagcactcac gccctaagcg cacattcatg tgggcatttc    26580

ttgcgagcct cgcagcctcc ggaagctgtc gacttcatga caagcatttt gtgaactagg    26640

gaagctcagg ggggttactg gcttctcttg agtcacactg ctagcaaatg gcagaaccaa    26700

agctcaaata aaaataaaat aattttcatt cattcactca                          26740


