                         SEQUENCE LISTING

<110>  Bhatt, Rupal S.
       Kumar, Ravindra
       Mier, James W.
       Pearsall, Robert
       Sherman, Matthew
       Solban, Nicolas
 
<120>  ALK1 Antagonists and Their Uses in Treating Renal Cell Carcinoma

<130>  3174.001PC02/TJS/KKH

<140>  To be assigned
<141>  2013-02-01

<150>  US 61/593,864
<151>  2012-02-02

<150>  US 61/597,124
<151>  2012-02-09

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  503
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Thr Leu Gly Ser Pro Arg Lys Gly Leu Leu Met Leu Leu Met Ala 
1               5                   10                  15      


Leu Val Thr Gln Gly Asp Pro Val Lys Pro Ser Arg Gly Pro Leu Val 
            20                  25                  30          


Thr Cys Thr Cys Glu Ser Pro His Cys Lys Gly Pro Thr Cys Arg Gly 
        35                  40                  45              


Ala Trp Cys Thr Val Val Leu Val Arg Glu Glu Gly Arg His Pro Gln 
    50                  55                  60                  


Glu His Arg Gly Cys Gly Asn Leu His Arg Glu Leu Cys Arg Gly Arg 
65                  70                  75                  80  


Pro Thr Glu Phe Val Asn His Tyr Cys Cys Asp Ser His Leu Cys Asn 
                85                  90                  95      


His Asn Val Ser Leu Val Leu Glu Ala Thr Gln Pro Pro Ser Glu Gln 
            100                 105                 110         


Pro Gly Thr Asp Gly Gln Leu Ala Leu Ile Leu Gly Pro Val Leu Ala 
        115                 120                 125             


Leu Leu Ala Leu Val Ala Leu Gly Val Leu Gly Leu Trp His Val Arg 
    130                 135                 140                 


Arg Arg Gln Glu Lys Gln Arg Gly Leu His Ser Glu Leu Gly Glu Ser 
145                 150                 155                 160 


Ser Leu Ile Leu Lys Ala Ser Glu Gln Gly Asp Ser Met Leu Gly Asp 
                165                 170                 175     


Leu Leu Asp Ser Asp Cys Thr Thr Gly Ser Gly Ser Gly Leu Pro Phe 
            180                 185                 190         


Leu Val Gln Arg Thr Val Ala Arg Gln Val Ala Leu Val Glu Cys Val 
        195                 200                 205             


Gly Lys Gly Arg Tyr Gly Glu Val Trp Arg Gly Leu Trp His Gly Glu 
    210                 215                 220                 


Ser Val Ala Val Lys Ile Phe Ser Ser Arg Asp Glu Gln Ser Trp Phe 
225                 230                 235                 240 


Arg Glu Thr Glu Ile Tyr Asn Thr Val Leu Leu Arg His Asp Asn Ile 
                245                 250                 255     


Leu Gly Phe Ile Ala Ser Asp Met Thr Ser Arg Asn Ser Ser Thr Gln 
            260                 265                 270         


Leu Trp Leu Ile Thr His Tyr His Glu His Gly Ser Leu Tyr Asp Phe 
        275                 280                 285             


Leu Gln Arg Gln Thr Leu Glu Pro His Leu Ala Leu Arg Leu Ala Val 
    290                 295                 300                 


Ser Ala Ala Cys Gly Leu Ala His Leu His Val Glu Ile Phe Gly Thr 
305                 310                 315                 320 


Gln Gly Lys Pro Ala Ile Ala His Arg Asp Phe Lys Ser Arg Asn Val 
                325                 330                 335     


Leu Val Lys Ser Asn Leu Gln Cys Cys Ile Ala Asp Leu Gly Leu Ala 
            340                 345                 350         


Val Met His Ser Gln Gly Ser Asp Tyr Leu Asp Ile Gly Asn Asn Pro 
        355                 360                 365             


Arg Val Gly Thr Lys Arg Tyr Met Ala Pro Glu Val Leu Asp Glu Gln 
    370                 375                 380                 


Ile Arg Thr Asp Cys Phe Glu Ser Tyr Lys Trp Thr Asp Ile Trp Ala 
385                 390                 395                 400 


Phe Gly Leu Val Leu Trp Glu Ile Ala Arg Arg Thr Ile Val Asn Gly 
                405                 410                 415     


Ile Val Glu Asp Tyr Arg Pro Pro Phe Tyr Asp Val Val Pro Asn Asp 
            420                 425                 430         


Pro Ser Phe Glu Asp Met Lys Lys Val Val Cys Val Asp Gln Gln Thr 
        435                 440                 445             


Pro Thr Ile Pro Asn Arg Leu Ala Ala Asp Pro Val Leu Ser Gly Leu 
    450                 455                 460                 


Ala Gln Met Met Arg Glu Cys Trp Tyr Pro Asn Pro Ser Ala Arg Leu 
465                 470                 475                 480 


Thr Ala Leu Arg Ile Lys Lys Thr Leu Gln Lys Ile Ser Asn Ser Pro 
                485                 490                 495     


Glu Lys Pro Lys Val Ile Gln 
            500             


<210>  2
<211>  1512
<212>  DNA
<213>  Homo sapiens

<400>  2
atgaccttgg gctcccccag gaaaggcctt ctgatgctgc tgatggcctt ggtgacccag       60

ggagaccctg tgaagccgtc tcggggcccg ctggtgacct gcacgtgtga gagcccacat      120

tgcaaggggc ctacctgccg gggggcctgg tgcacagtag tgctggtgcg ggaggagggg      180

aggcaccccc aggaacatcg gggctgcggg aacttgcaca gggagctctg cagggggcgc      240

cccaccgagt tcgtcaacca ctactgctgc gacagccacc tctgcaacca caacgtgtcc      300

ctggtgctgg aggccaccca acctccttcg gagcagccgg gaacagatgg ccagctggcc      360

ctgatcctgg gccccgtgct ggccttgctg gccctggtgg ccctgggtgt cctgggcctg      420

tggcatgtcc gacggaggca ggagaagcag cgtggcctgc acagcgagct gggagagtcc      480

agtctcatcc tgaaagcatc tgagcagggc gacagcatgt tgggggacct cctggacagt      540

gactgcacca cagggagtgg ctcagggctc cccttcctgg tgcagaggac agtggcacgg      600

caggttgcct tggtggagtg tgtgggaaaa ggccgctatg gcgaagtgtg gcggggcttg      660

tggcacggtg agagtgtggc cgtcaagatc ttctcctcga gggatgaaca gtcctggttc      720

cgggagactg agatctataa cacagtgttg ctcagacacg acaacatcct aggcttcatc      780

gcctcagaca tgacctcccg caactcgagc acgcagctgt ggctcatcac gcactaccac      840

gagcacggct ccctctacga ctttctgcag agacagacgc tggagcccca tctggctctg      900

aggctagctg tgtccgcggc atgcggcctg gcgcacctgc acgtggagat cttcggtaca      960

cagggcaaac cagccattgc ccaccgcgac ttcaagagcc gcaatgtgct ggtcaagagc     1020

aacctgcagt gttgcatcgc cgacctgggc ctggctgtga tgcactcaca gggcagcgat     1080

tacctggaca tcggcaacaa cccgagagtg ggcaccaagc ggtacatggc acccgaggtg     1140

ctggacgagc agatccgcac ggactgcttt gagtcctaca agtggactga catctgggcc     1200

tttggcctgg tgctgtggga gattgcccgc cggaccatcg tgaatggcat cgtggaggac     1260

tatagaccac ccttctatga tgtggtgccc aatgacccca gctttgagga catgaagaag     1320

gtggtgtgtg tggatcagca gacccccacc atccctaacc ggctggctgc agacccggtc     1380

ctctcaggcc tagctcagat gatgcgggag tgctggtacc caaacccctc tgcccgactc     1440

accgcgctgc ggatcaagaa gacactacaa aaaattagca acagtccaga gaagcctaaa     1500

gtgattcaat ag                                                         1512


<210>  3
<211>  328
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinant protein

<400>  3

Asp Pro Val Lys Pro Ser Arg Gly Pro Leu Val Thr Cys Thr Cys Glu 
1               5                   10                  15      


Ser Pro His Cys Lys Gly Pro Thr Cys Arg Gly Ala Trp Cys Thr Val 
            20                  25                  30          


Val Leu Val Arg Glu Glu Gly Arg His Pro Gln Glu His Arg Gly Cys 
        35                  40                  45              


Gly Asn Leu His Arg Glu Leu Cys Arg Gly Arg Pro Thr Glu Phe Val 
    50                  55                  60                  


Asn His Tyr Cys Cys Asp Ser His Leu Cys Asn His Asn Val Ser Leu 
65                  70                  75                  80  


Val Leu Glu Ala Thr Gln Pro Pro Ser Glu Gln Pro Gly Thr Asp Gly 
                85                  90                  95      


Gln Leu Ala Thr Gly Gly Gly Thr His Thr Cys Pro Pro Cys Pro Ala 
            100                 105                 110         


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        115                 120                 125             


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    130                 135                 140                 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
145                 150                 155                 160 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                165                 170                 175     


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
            180                 185                 190         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
        195                 200                 205             


Leu Pro Val Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    210                 215                 220                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
225                 230                 235                 240 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                245                 250                 255     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            260                 265                 270         


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        275                 280                 285             


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
    290                 295                 300                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
305                 310                 315                 320 


Ser Leu Ser Leu Ser Pro Gly Lys 
                325             


<210>  4
<211>  1075
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Recombinant DNA

<400>  4
gctagcacca tggatgcaat gaagagaggg ctctgctgtg tgctgctgct gtgtggagca       60

gtcttcgttt cgcccggcgc cgaccctgtg aagccgtctc ggggcccgct ggtgacctgc      120

acgtgtgaga gcccacattg caaggggcct acctgccggg gggcctggtg cacagtagtg      180

ctggtgcggg aggaggggag gcacccccag gaacatcggg gctgcgggaa cttgcacagg      240

gagctctgca ggggccgccc caccgagttc gtcaaccact actgctgcga cagccacctc      300

tgcaaccaca acgtgtccct ggtgctggag gccacccaac ctccttcgga gcagccggga      360

acagatggcc agctggccac cggtggtgga actcacacat gcccaccgtg cccagcacct      420

gaagccctgg gggcaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      480

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      540

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      600

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      660

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agtccccatc      720

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      780

ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      840

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      900

accacgcctc ccgtgctgga ctccgacggc cccttcttcc tctacagcaa gctcaccgtg      960

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1020

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaatgagg aattc          1075


<210>  5
<211>  352
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinant protein

<400>  5

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Gly Ala Asp Pro Val Lys Pro Ser Arg Gly 
            20                  25                  30          


Pro Leu Val Thr Cys Thr Cys Glu Ser Pro His Cys Lys Gly Pro Thr 
        35                  40                  45              


Cys Arg Gly Ala Trp Cys Thr Val Val Leu Val Arg Glu Glu Gly Arg 
    50                  55                  60                  


His Pro Gln Glu His Arg Gly Cys Gly Asn Leu His Arg Glu Leu Cys 
65                  70                  75                  80  


Arg Gly Arg Pro Thr Glu Phe Val Asn His Tyr Cys Cys Asp Ser His 
                85                  90                  95      


Leu Cys Asn His Asn Val Ser Leu Val Leu Glu Ala Thr Gln Pro Pro 
            100                 105                 110         


Ser Glu Gln Pro Gly Thr Asp Gly Gln Leu Ala Thr Gly Gly Gly Thr 
        115                 120                 125             


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Leu Gly Ala Pro Ser 
    130                 135                 140                 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
145                 150                 155                 160 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
                165                 170                 175     


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
            180                 185                 190         


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
        195                 200                 205             


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
    210                 215                 220                 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Val Pro Ile Glu Lys Thr 
225                 230                 235                 240 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                245                 250                 255     


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
            260                 265                 270         


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
        275                 280                 285             


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
    290                 295                 300                 


Ser Asp Gly Pro Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
305                 310                 315                 320 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
                325                 330                 335     


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345                 350         


<210>  6
<211>  225
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  residue may optionally be mutated to alanine

<220>
<221>  misc_feature
<222>  (100)..(100)
<223>  residue may optionally be mutated to alanine

<220>
<221>  misc_feature
<222>  (212)..(212)
<223>  residue may optionally be mutated to alanine

<400>  6

Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
1               5                   10                  15      


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            20                  25                  30          


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
        35                  40                  45              


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    50                  55                  60                  


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
65                  70                  75                  80  


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                85                  90                  95      


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Val Pro Ile Glu Lys 
            100                 105                 110         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        115                 120                 125             


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
    130                 135                 140                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
145                 150                 155                 160 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                165                 170                 175     


Asp Ser Asp Gly Pro Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
            180                 185                 190         


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        195                 200                 205             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    210                 215                 220                 


Lys 
225 


<210>  7
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinant leader peptide

<400>  7

Met Lys Phe Leu Val Asn Val Ala Leu Val Phe Met Val Val Tyr Ile 
1               5                   10                  15      


Ser Tyr Ile Tyr Ala 
            20      


<210>  8
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinant leader peptide

<400>  8

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro 
            20          


<210>  9
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinant leader peptide

<400>  9

Met Thr Leu Gly Ser Pro Arg Lys Gly Leu Leu Met Leu Leu Met Ala 
1               5                   10                  15      


Leu Val Thr Gln Gly 
            20      


<210>  10
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Leu Arg Val Leu Val Gly Ala Val Leu Pro Ala Met Leu Leu Ala 
1               5                   10                  15      


Ala Pro Pro Pro Ile Asn Lys Leu Ala Leu Phe Pro Asp Lys Ser Ala 
            20                  25                  30          


Trp Cys Glu Ala Lys Asn Ile Thr Gln Ile Val Gly His Ser Gly Cys 
        35                  40                  45              


Glu Ala Lys Ser Ile Gln Asn Arg Ala Cys Leu Gly Gln Cys Phe Ser 
    50                  55                  60                  


Tyr Ser Val Pro Asn Thr Phe Pro Gln Ser Thr Glu Ser Leu Val His 
65                  70                  75                  80  


Cys Asp Ser Cys Met Pro Ala Gln Ser Met Trp Glu Ile Val Thr Leu 
                85                  90                  95      


Glu Cys Pro Gly His Glu Glu Val Pro Arg Val Asp Lys Leu Val Glu 
            100                 105                 110         


Lys Ile Leu His Cys Ser Cys Gln Ala Cys Gly Lys Glu Pro Ser His 
        115                 120                 125             


Glu Gly Leu Ser Val Tyr Val Gln Gly Glu Asp Gly Pro Gly Ser Gln 
    130                 135                 140                 


Pro Gly Thr His Pro His Pro His Pro His Pro His Pro Gly Gly Gln 
145                 150                 155                 160 


Thr Pro Glu Pro Glu Asp Pro Pro Gly Ala Pro His Thr Glu Glu Glu 
                165                 170                 175     


Gly Ala Glu Asp 
            180 


<210>  11
<211>  2003
<212>  DNA
<213>  Homo sapiens

<400>  11
gccgagcctc ctggggcgcc cgggcccgcg acccccgcac ccagctccgc aggaccggcg       60

ggcgcgcgcg ggctctggag gccacgggca tgatgcttcg ggtcctggtg ggggctgtcc      120

tccctgccat gctactggct gccccaccac ccatcaacaa gctggcactg ttcccagata      180

agagtgcctg gtgcgaagcc aagaacatca cccagatcgt gggccacagc ggctgtgagg      240

ccaagtccat ccagaacagg gcgtgcctag gacagtgctt cagctacagc gtccccaaca      300

ccttcccaca gtccacagag tccctggttc actgtgactc ctgcatgcca gcccagtcca      360

tgtgggagat tgtgacgctg gagtgcccgg gccacgagga ggtgcccagg gtggacaagc      420

tggtggagaa gatcctgcac tgtagctgcc aggcctgcgg caaggagcct agtcacgagg      480

ggctgagcgt ctatgtgcag ggcgaggacg ggccgggatc ccagcccggc acccaccctc      540

acccccatcc ccacccccat cctggcgggc agacccctga gcccgaggac ccccctgggg      600

ccccccacac agaggaagag ggggctgagg actgaggccc ccccaactct tcctcccctc      660

tcatccccct gtggaatgtt gggtctcact ctctggggaa gtcaggggag aagctgaagc      720

ccccctttgg cactggatgg acttggcttc agactcggac ttgaatgctg cccggttgcc      780

atggagatct gaaggggcgg ggttagagcc aagctgcaca atttaatata ttcaagagtg      840

gggggaggaa gcagaggtct tcagggctct ttttttgggg ggggggtggt ctcttcctgt      900

ctggcttcta gagatgtgcc tgtgggaggg ggaggaagtt ggctgagcca ttgagtgctg      960

ggggaggcca tccaagatgg catgaatcgg gctaaggtcc ctgggggtgc agatggtact     1020

gctgaggtcc cgggcttagt gtgagcatct tgccagcctc aggcttgagg gagggctggg     1080

ctagaaagac cactggcaga aacaggaggc tccggcccca caggtttccc caaggcctct     1140

caccccactt cccatctcca gggaagcgtc gccccagtgg cactgaagtg gccctccctc     1200

agcggagggg tttgggagtc aggcctgggc aggaccctgc tgactcgtgg cgcgggagct     1260

gggagccagg ctctccgggc ctttctctgg cttccttggc ttgcctggtg ggggaagggg     1320

aggaggggaa gaaggaaagg gaagagtctt ccaaggccag aaggaggggg acaacccccc     1380

aagaccatcc ctgaagacga gcatccccct cctctccctg ttagaaatgt tagtgccccg     1440

cactgtgccc caagttctag gccccccaga aagctgtcag agccggccgc cttctcccct     1500

ctcccaggga tgctctttgt aaatatcgga tgggtgtggg agtgaggggt tacctccctc     1560

gccccaaggt tccagaggcc ctaggcggga tgggctcgct gaacctcgag gaactccagg     1620

acgaggagga catgggactt gcgtggacag tcagggttca cttgggctct ctctagctcc     1680

ccaattctgc ctgcctcctc cctcccagct gcactttaac cctagaaggt ggggacctgg     1740

ggggagggac agggcaggcg ggcccatgaa gaaagcccct cgttgcccag cactgtctgc     1800

gtctgctctt ctgtgcccag ggtggctgcc agcccactgc ctcctgcctg gggtggcctg     1860

gccctcctgg ctgttgcgac gcgggcttct ggagcttgtc accattggac agtctccctg     1920

atggaccctc agtcttctca tgaataaatt ccttcaacgc caaaaaaaaa aaaaaaaaaa     1980

aaaaaaaaaa aaaaaaaaaa aaa                                             2003


<210>  12
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinant protein

<400>  12

Arg Ser Ala Gly Ala Gly Ser His Cys Gln Lys Thr Ser Leu Arg Val 
1               5                   10                  15      


Asn Phe Glu Asp Ile Gly Trp Asp Ser Trp Ile Ile Ala Pro Lys Glu 
            20                  25                  30          


Tyr Glu Ala Tyr Glu Cys Lys Gly Gly Cys Phe Phe Pro Leu Ala Asp 
        35                  40                  45              


Asp Val Thr Pro Thr Lys His Ala Ile Val Gln Thr Leu Val His Leu 
    50                  55                  60                  


Lys Phe Pro Thr Lys Val Gly Lys Ala Cys Cys Val Pro Thr Lys Leu 
65                  70                  75                  80  


Ser Pro Ile Ser Val Leu Tyr Lys Asp Asp Met Gly Val Pro Thr Leu 
                85                  90                  95      


Lys Tyr His Tyr Glu Gly Met Ser Val Ala Glu Cys Gly Cys Arg 
            100                 105                 110     


<210>  13
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinant protein

<400>  13

Asn Ala Lys Gly Asn Tyr Cys Lys Arg Thr Pro Leu Tyr Ile Asp Phe 
1               5                   10                  15      


Lys Glu Ile Gly Trp Asp Ser Trp Ile Ile Ala Pro Pro Gly Tyr Glu 
            20                  25                  30          


Ala Tyr Glu Cys Arg Gly Val Cys Asn Tyr Pro Leu Ala Glu His Leu 
        35                  40                  45              


Thr Pro Thr Lys His Ala Ile Ile Gln Ala Leu Val His Leu Lys Asn 
    50                  55                  60                  


Ser Gln Lys Ala Ser Lys Ala Cys Cys Val Pro Thr Lys Leu Glu Pro 
65                  70                  75                  80  


Ile Ser Ile Leu Tyr Leu Asp Lys Gly Val Val Thr Tyr Lys Phe Lys 
                85                  90                  95      


Tyr Glu Gly Met Ala Val Ser Glu Cys Gly Cys Arg 
            100                 105             


<210>  14
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  14

Asp Pro Val Lys Pro Ser Arg Gly Pro Leu Val Thr Cys Thr Cys Glu 
1               5                   10                  15      


Ser Pro His Cys Lys Gly Pro Thr Cys Arg Gly Ala Trp Cys Thr Val 
            20                  25                  30          


Val Leu Val Arg Glu Glu Gly Arg His Pro Gln Glu His Arg Gly Cys 
        35                  40                  45              


Gly Asn Leu His Arg Glu Leu Cys Arg Gly Arg Pro Thr Glu Phe Val 
    50                  55                  60                  


Asn His Tyr Cys Cys Asp Ser His Leu Cys Asn His Asn Val Ser Leu 
65                  70                  75                  80  


Val Leu Glu Ala Thr Gln Pro Pro Ser Glu Gln Pro Gly Thr Asp Gly 
                85                  90                  95      


Gln Leu Ala Thr Gly Gly Gly Thr His Thr Cys Pro Pro Cys Pro Ala 
            100                 105                 110         


Pro Glu Ala Leu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        115                 120                 125             


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    130                 135                 140                 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
145                 150                 155                 160 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                165                 170                 175     


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
            180                 185                 190         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
        195                 200                 205             


Leu Pro Val Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    210                 215                 220                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
225                 230                 235                 240 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                245                 250                 255     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            260                 265                 270         


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Pro Phe Phe Leu Tyr 
        275                 280                 285             


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
    290                 295                 300                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
305                 310                 315                 320 


Ser Leu Ser Leu Ser Pro Gly Lys 
                325             


<210>  15
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  15

Arg Ser Ala Gly Ala Gly Ser His Cys Gln Lys Thr Ser Leu Arg Val 
1               5                   10                  15      


Asn Phe Glu Asp Ile Gly Trp Asp Ser Trp Ile Ile Ala Pro Lys Glu 
            20                  25                  30          


Tyr Glu Ala Tyr Glu Cys Lys Gly Gly Cys Phe Phe Pro Leu Ala Asp 
        35                  40                  45              


Asp Val Thr Pro Thr Lys His Ala Ile Val Gln Thr Leu Asn Ala Lys 
    50                  55                  60                  


Gly Asn Tyr Cys Lys Arg Thr Pro Leu Tyr Ile Asp Phe Lys Glu Ile 
65                  70                  75                  80  


Gly Trp Asp Ser Trp Ile Ile Ala Pro Pro Gly Tyr Glu Ala Tyr Glu 
                85                  90                  95      


Cys Arg Gly Val Cys Asn Tyr Pro Leu Ala Glu His Leu Thr Pro Thr 
            100                 105                 110         


Lys His Ala Ile Ile Gln Ala Leu 
        115                 120 


<210>  16
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  16

Val His Leu Lys Phe Pro Thr Lys Val Gly Lys Ala Cys Cys Val Pro 
1               5                   10                  15      


Thr Lys Leu Ser Pro Ile Ser Val Leu Tyr Lys Asp Asp Met Gly Val 
            20                  25                  30          


Pro Thr Leu Lys Tyr His Tyr Glu Gly Met Ser Val Ala Glu Cys Gly 
        35                  40                  45              


Cys Arg Val His Leu Lys Asn Ser Gln Lys Ala Ser Lys Ala Cys Cys 
    50                  55                  60                  


Val Pro Thr Lys Leu Glu Pro Ile Ser Ile Leu Tyr Leu Asp Lys Gly 
65                  70                  75                  80  


Val Val Thr Tyr Lys Phe Lys Tyr Glu Gly Met Ala Val Ser Glu Cys 
                85                  90                  95      


Gly Cys Arg 
            


