                               SEQUENCE LISTING

<110> THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
 
<120> RETINALDEHYDE MIMETICS AND INHIBITORS OF RETINALDEHYDE 
      DEHYDROGENASE I IN THE TREATMENT OF DISORDERS

<130> 043214-075542-PCT

<140>
<141>

<150> 61/642,815
<151> 2012-05-04

<150> 61/594,841
<151> 2012-02-03

<160> 14    

<170> PatentIn version 3.5

<210> 1
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1
aacacgacta tgctggttac                                                   20


<210> 2
<211> 29
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 2
Ala Ala Leu Glu Ala Leu Ala Glu Ala Leu Glu Ala Leu Ala Glu Ala 
1               5                   10                  15      


Leu Glu Ala Leu Ala Glu Ala Ala Ala Ala Gly Gly Cys 
            20                  25                  


<210> 3
<211> 2378
<212> DNA
<213> Homo sapiens

<400> 3
gctgcataca cttatcacag gtttcggctt tgtaaattaa ttcatctgca aatagtgcac       60

tgtctccagg tacaaattcg atgctggagc actggtttct taaggattta agtttaaagt      120

caaaggcttc ctgccctagg tgttacaaat aagtagtgtc gttttctttt tttgctctga      180

gtttgttcat ccaatcgtat ccgagtatgc aaataaactt tagcccgtgc agataaaaaa      240

ggaacaaata aagccaagtg ctctatcaga accaaattgc tgagccagtc acctgtgttc      300

caggagccga atcagaaatg tcatcctcag gcacgccaga cttacctgtc ctactcaccg      360

atttgaagat tcaatatact aagatcttca taaacaatga atggcatgat tcagtgagtg      420

gcaagaaatt tcctgtcttt aatcctgcaa ctgaggagga gctctgccag gtagaagaag      480

gagataagga ggatgttgac aaggcagtga aggccgcaag acaggctttt cagattggat      540

ccccgtggcg tactatggat gcttccgaga gggggcgact attatacaag ttggctgatt      600

taatcgaaag agatcgtctg ctgctggcga caatggagtc aatgaatggt ggaaaactct      660

attccaatgc atatctgaat gatttagcag gctgcatcaa aacattgcgc tactgtgcag      720

gttgggctga caagatccag ggccgtacaa taccaattga tggaaatttt tttacatata      780

caagacatga acctattggt gtatgtggcc aaatcattcc ttggaatttc ccgttggtta      840

tgctcatttg gaagataggg cctgcactga gctgtggaaa cacagtggtt gtcaaaccag      900

cagagcaaac tcctctcact gctctccacg tggcatcttt aataaaagag gcagggtttc      960

ctcctggagt agtgaatatt gttcctggtt atgggcctac agcaggggca gccatttctt     1020

ctcacatgga tatagacaaa gtagccttca caggatcaac agaggttggc aagttgatca     1080

aagaagctgc cgggaaaagc aatctgaaga gggtgaccct ggagcttgga ggaaagagcc     1140

cttgcattgt gttagctgat gccgacttgg acaatgctgt tgaatttgca caccatgggg     1200

tattctacca ccagggccag tgttgtatag ccgcatccag gatttttgtg gaagaatcaa     1260

tttatgatga gtttgttcga aggagtgttg agcgggctaa gaagtatatc cttggaaatc     1320

ctctgacccc aggagtcact caaggccctc agattgacaa ggaacaatat gataaaatac     1380

ttgacctcat tgagagtggg aagaaagaag gggccaaact ggaatgtgga ggaggcccgt     1440

gggggaataa aggctacttt gtccagccca cagtgttctc taatgttaca gatgagatgc     1500

gcattgccaa agaggagatt tttggaccag tgcagcaaat catgaagttt aaatctttag     1560

atgacgtgat caaaagagca aacaatactt tctatggctt atcagcagga gtgtttacca     1620

aagacattga taaagccata acaatctcct ctgctctgca ggcaggaaca gtgtgggtga     1680

attgctatgg cgtggtaagt gcccagtgcc cctttggtgg attcaagatg tctggaaatg     1740

gaagagaact gggagagtac ggtttccatg aatatacaga ggtcaaaaca gtcacagtga     1800

aaatctctca gaagaactca taaagaaaat acaagagtgg agagaagctc ttcaatagct     1860

aagcatctcc ttacagtcac taatatagta gattttaaag acaaaatttt tcttttcttg     1920

atttttttaa acataagcta aatcatatta gtattaatac tacccataga aaacttgaca     1980

tgtagcttct tctgaaagaa ttatttgcct tctgaaatgt gacccccaag tcctatccta     2040

aataaaaaaa gacaaattcg gatgtatgat ctctctagct ttgtcatagt tatgtgattt     2100

tcctttgtag ctacttttgc aggataataa ttttatagaa aaggaacagt tgcatttagc     2160

ttctttccct tagtgactct tgaagtactt aacatacacg ttaactgcag agtaaattgc     2220

tctgttccca gtagttataa agtccttgga ctgttttgaa aagtttccta ggatgtcatg     2280

tctgcttgtc aaaagaaata atccctgtaa tatttagctg taaactgaat ataaagctta     2340

ataaaaacaa ccttgcatga ttcttgttaa aaaaaaaa                             2378


<210> 4
<211> 501
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Met Ser Ser Ser Gly Thr Pro Asp Leu Pro Val Leu Leu Thr Asp Leu 
1               5                   10                  15      


Lys Ile Gln Tyr Thr Lys Ile Phe Ile Asn Asn Glu Trp His Asp Ser 
            20                  25                  30          


Val Ser Gly Lys Lys Phe Pro Val Phe Asn Pro Ala Thr Glu Glu Glu 
        35                  40                  45              


Leu Cys Gln Val Glu Glu Gly Asp Lys Glu Asp Val Asp Lys Ala Val 
    50                  55                  60                  


Lys Ala Ala Arg Gln Ala Phe Gln Ile Gly Ser Pro Trp Arg Thr Met 
65                  70                  75                  80  


Asp Ala Ser Glu Arg Gly Arg Leu Leu Tyr Lys Leu Ala Asp Leu Ile 
                85                  90                  95      


Glu Arg Asp Arg Leu Leu Leu Ala Thr Met Glu Ser Met Asn Gly Gly 
            100                 105                 110         


Lys Leu Tyr Ser Asn Ala Tyr Leu Asn Asp Leu Ala Gly Cys Ile Lys 
        115                 120                 125             


Thr Leu Arg Tyr Cys Ala Gly Trp Ala Asp Lys Ile Gln Gly Arg Thr 
    130                 135                 140                 


Ile Pro Ile Asp Gly Asn Phe Phe Thr Tyr Thr Arg His Glu Pro Ile 
145                 150                 155                 160 


Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Leu Val Met Leu 
                165                 170                 175     


Ile Trp Lys Ile Gly Pro Ala Leu Ser Cys Gly Asn Thr Val Val Val 
            180                 185                 190         


Lys Pro Ala Glu Gln Thr Pro Leu Thr Ala Leu His Val Ala Ser Leu 
        195                 200                 205             


Ile Lys Glu Ala Gly Phe Pro Pro Gly Val Val Asn Ile Val Pro Gly 
    210                 215                 220                 


Tyr Gly Pro Thr Ala Gly Ala Ala Ile Ser Ser His Met Asp Ile Asp 
225                 230                 235                 240 


Lys Val Ala Phe Thr Gly Ser Thr Glu Val Gly Lys Leu Ile Lys Glu 
                245                 250                 255     


Ala Ala Gly Lys Ser Asn Leu Lys Arg Val Thr Leu Glu Leu Gly Gly 
            260                 265                 270         


Lys Ser Pro Cys Ile Val Leu Ala Asp Ala Asp Leu Asp Asn Ala Val 
        275                 280                 285             


Glu Phe Ala His His Gly Val Phe Tyr His Gln Gly Gln Cys Cys Ile 
    290                 295                 300                 


Ala Ala Ser Arg Ile Phe Val Glu Glu Ser Ile Tyr Asp Glu Phe Val 
305                 310                 315                 320 


Arg Arg Ser Val Glu Arg Ala Lys Lys Tyr Ile Leu Gly Asn Pro Leu 
                325                 330                 335     


Thr Pro Gly Val Thr Gln Gly Pro Gln Ile Asp Lys Glu Gln Tyr Asp 
            340                 345                 350         


Lys Ile Leu Asp Leu Ile Glu Ser Gly Lys Lys Glu Gly Ala Lys Leu 
        355                 360                 365             


Glu Cys Gly Gly Gly Pro Trp Gly Asn Lys Gly Tyr Phe Val Gln Pro 
    370                 375                 380                 


Thr Val Phe Ser Asn Val Thr Asp Glu Met Arg Ile Ala Lys Glu Glu 
385                 390                 395                 400 


Ile Phe Gly Pro Val Gln Gln Ile Met Lys Phe Lys Ser Leu Asp Asp 
                405                 410                 415     


Val Ile Lys Arg Ala Asn Asn Thr Phe Tyr Gly Leu Ser Ala Gly Val 
            420                 425                 430         


Phe Thr Lys Asp Ile Asp Lys Ala Ile Thr Ile Ser Ser Ala Leu Gln 
        435                 440                 445             


Ala Gly Thr Val Trp Val Asn Cys Tyr Gly Val Val Ser Ala Gln Cys 
    450                 455                 460                 


Pro Phe Gly Gly Phe Lys Met Ser Gly Asn Gly Arg Glu Leu Gly Glu 
465                 470                 475                 480 


Tyr Gly Phe His Glu Tyr Thr Glu Val Lys Thr Val Thr Val Lys Ile 
                485                 490                 495     


Ser Gln Lys Asn Ser 
            500     


<210> 5
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Ala Ala Leu Ala Glu Ala Leu Ala Glu Ala Leu Ala Glu Ala Leu Ala 
1               5                   10                  15      


Glu Ala Leu Ala Glu Ala Leu Ala Ala Ala Ala Gly Gly Cys 
            20                  25                  30  


<210> 6
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 6
Ala Leu Glu Ala Leu Ala Glu Ala Leu Glu Ala Leu Ala Glu Ala 
1               5                   10                  15  


<210> 7
<211> 16
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Exemplary hydrophobic 
      membrane translocation containing peptide

<400> 7
Ala Ala Val Ala Leu Leu Pro Ala Val Leu Leu Ala Leu Leu Ala Pro 
1               5                   10                  15      


<210> 8
<211> 11
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: RFGF 
      analogue peptide

<400> 8
Ala Ala Leu Leu Pro Val Leu Leu Ala Ala Pro 
1               5                   10      


<210> 9
<211> 13
<212> PRT
<213> Human immunodeficiency virus

<400> 9
Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210> 10
<211> 16
<212> PRT
<213> Drosophila sp.

<400> 10
Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210> 11
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 11
cgtggcgtac tatggatgc                                                    19


<210> 12
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 12
gcagcagacg atctctttcg                                                   20


<210> 13
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 13
ccatggatgc ttcagagagg                                                   20


<210> 14
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 14
actttcccac cattgagtgc                                                   20



