                         SEQUENCE LISTING

<110>  Yeda Research and Development Co. Ltd.
 
<120>  FUSION PROTEINS COMPRISING TYPE-II COHESIN MODULES, MULTI-ENZYME 
       COMPLEXES COMPRISING SAME AND USES THEREOF

<130>  YEDA/0123 PCT

<150>  US 61/592027
<151>  2012-01-30

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  1

Met Ala Lys Ile Thr Phe Pro Lys Asp Phe Ile Trp Gly Ser Ala Thr 
1               5                   10                  15      


Ala Ala Tyr Gln Ile Glu Gly Ala Tyr Asn Glu Asp Gly Lys Gly Glu 
            20                  25                  30          


Ser Ile Trp Asp Arg Phe Ser His Thr Pro Gly Asn Ile Ala Asp Gly 
        35                  40                  45              


His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Glu Glu Asp 
    50                  55                  60                  


Ile Lys Ile Met Lys Glu Ile Gly Ile Lys Ser Tyr Arg Phe Ser Ile 
65                  70                  75                  80  


Ser Trp Pro Arg Ile Phe Pro Glu Gly Thr Gly Lys Leu Asn Gln Lys 
                85                  90                  95      


Gly Leu Asp Phe Tyr Lys Arg Leu Thr Asn Leu Leu Leu Glu Asn Gly 
            100                 105                 110         


Ile Met Pro Ala Ile Thr Leu Tyr His Trp Asp Leu Pro Gln Lys Leu 
        115                 120                 125             


Gln Asp Lys Gly Gly Trp Lys Asn Arg Asp Thr Thr Asp Tyr Phe Thr 
    130                 135                 140                 


Glu Tyr Ser Glu Val Ile Phe Lys Asn Leu Gly Asp Ile Val Pro Ile 
145                 150                 155                 160 


Trp Phe Thr His Asn Glu Pro Gly Val Val Ser Leu Leu Gly His Phe 
                165                 170                 175     


Leu Gly Ile His Ala Pro Gly Ile Lys Asp Leu Arg Thr Ser Leu Glu 
            180                 185                 190         


Val Ser His Asn Leu Leu Leu Ser His Gly Lys Ala Val Lys Leu Phe 
        195                 200                 205             


Arg Glu Met Asn Ile Asp Ala Gln Ile Gly Ile Ala Leu Asn Leu Ser 
    210                 215                 220                 


Tyr His Tyr Pro Ala Ser Glu Lys Ala Glu Asp Ile Glu Ala Ala Glu 
225                 230                 235                 240 


Leu Ser Phe Ser Leu Ala Gly Arg Trp Tyr Leu Asp Pro Val Leu Lys 
                245                 250                 255     


Gly Arg Tyr Pro Glu Asn Ala Leu Lys Leu Tyr Lys Lys Lys Gly Ile 
            260                 265                 270         


Glu Leu Ser Phe Pro Glu Asp Asp Leu Lys Leu Ile Ser Gln Pro Ile 
        275                 280                 285             


Asp Phe Ile Ala Phe Asn Asn Tyr Ser Ser Glu Phe Ile Lys Tyr Asp 
    290                 295                 300                 


Pro Ser Ser Glu Ser Gly Phe Ser Pro Ala Asn Ser Ile Leu Glu Lys 
305                 310                 315                 320 


Phe Glu Lys Thr Asp Met Gly Trp Ile Ile Tyr Pro Glu Gly Leu Tyr 
                325                 330                 335     


Asp Leu Leu Met Leu Leu Asp Arg Asp Tyr Gly Lys Pro Asn Ile Val 
            340                 345                 350         


Ile Ser Glu Asn Gly Ala Ala Phe Lys Asp Glu Ile Gly Ser Asn Gly 
        355                 360                 365             


Lys Ile Glu Asp Thr Lys Arg Ile Gln Tyr Leu Lys Asp Tyr Leu Thr 
    370                 375                 380                 


Gln Ala His Arg Ala Ile Gln Asp Gly Val Asn Leu Lys Ala Tyr Tyr 
385                 390                 395                 400 


Leu Trp Ser Leu Leu Asp Asn Phe Glu Trp Ala Tyr Gly Tyr Asn Lys 
                405                 410                 415     


Arg Phe Gly Ile Val His Val Asn Phe Asp Thr Leu Glu Arg Lys Ile 
            420                 425                 430         


Lys Asp Ser Gly Tyr Trp Tyr Lys Glu Val Ile Lys Asn Asn Gly Phe 
        435                 440                 445             


Leu Glu 
    450 


<210>  2
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  2
atggcaaaga taactttccc aaaagatttc atatggggtt ctgcaacagc agcatatcag       60

attgaaggtg catacaacga agacggcaaa ggtgaatcta tatgggaccg tttttcccac      120

acgccaggaa atatagcaga cggacatacc ggcgatgttg catgcgacca ctatcatcgt      180

tatgaagaag atatcaaaat aatgaaagaa atcggtatta aatcatacag gttttccatc      240

tcatggccca gaatctttcc tgaaggaaca ggtaaattaa atcaaaaggg actggatttt      300

tacaaaaggc tcacaaatct gcttctggaa aacggaatta tgcctgcaat cactctttat      360

cactgggacc ttccccaaaa gcttcaggat aaaggcggat ggaaaaaccg ggacaccacc      420

gattatttta cagaatactc tgaagtaata tttaaaaatc tcggagatat cgttccaata      480

tggtttactc acaatgaacc cggtgttgtt tctttgcttg gccacttttt aggaattcat      540

gcccctggga taaaagacct ccgcacttca ttggaagtct cgcacaatct tcttttgtcc      600

cacggcaagg ccgtgaaact gtttagagaa atgaatattg acgcccaaat tggaatagct      660

ctcaatttat cttaccatta tcccgcatcc gaaaaagctg aggatattga agcagcggaa      720

ttgtcatttt ctctggcggg aaggtggtat ctggatcctg tgctaaaagg ccggtatcct      780

gaaaacgcat tgaaacttta taaaaagaag ggtattgagc tttctttccc tgaagatgac      840

ctgaaactta tcagtcagcc aatagacttc atagcattca acaattattc ttcggaattt      900

ataaaatatg atccgtccag tgagtcaggt ttttcacctg caaactccat attagaaaag      960

ttcgaaaaaa cagatatggg ctggatcata tatcctgaag gcttgtatga tctgcttatg     1020

ctccttgaca gggattatgg aaagccaaac attgttatca gcgaaaacgg agccgccttc     1080

aaagatgaaa taggtagcaa cggaaagata gaagacacaa agagaatcca atatcttaaa     1140

gattatctga cccaggctca cagggcaatt caggacggtg taaacttaaa agcatactac     1200

ttgtggtcgc ttttggacaa ctttgaatgg gcttacgggt acaacaagag attcggaatc     1260

gttcacgtaa attttgatac gttggaaaga aaaataaagg atagcggcta ctggtacaaa     1320

gaagtaatca aaaacaacgg tttcctcgag                                      1350


<210>  3
<211>  169
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  3

Leu Pro Asp Asp Ala His Ile Ala Leu Glu Leu Asp Lys Thr Lys Val 
1               5                   10                  15      


Lys Val Gly Asp Val Ile Val Ala Thr Val Lys Ala Lys Asn Met Thr 
            20                  25                  30          


Ser Met Ala Gly Ile Gln Val Asn Ile Lys Tyr Asp Pro Glu Val Leu 
        35                  40                  45              


Gln Ala Ile Asp Pro Ala Thr Gly Lys Pro Phe Thr Lys Glu Thr Leu 
    50                  55                  60                  


Leu Val Asp Pro Glu Leu Leu Ser Asn Arg Glu Tyr Asn Pro Leu Leu 
65                  70                  75                  80  


Thr Ala Val Asn Asp Ile Asn Ser Gly Ile Ile Asn Tyr Ala Ser Cys 
                85                  90                  95      


Tyr Val Tyr Trp Asp Ser Tyr Arg Glu Ser Gly Val Ser Glu Ser Thr 
            100                 105                 110         


Gly Ile Ile Gly Lys Val Gly Phe Lys Val Leu Lys Ala Ala Asn Thr 
        115                 120                 125             


Thr Val Lys Leu Glu Glu Thr Arg Phe Thr Pro Asn Ser Ile Asp Gly 
    130                 135                 140                 


Thr Leu Val Ile Asp Trp Tyr Gly Gln Gln Ile Val Gly Tyr Lys Val 
145                 150                 155                 160 


Ile Gln Pro Asp Lys Ile Thr Val Ile 
                165                 


<210>  4
<211>  507
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  4
ttaccggacg atgcacacat tgctttggaa cttgacaaga caaaagtgaa agtgggagat       60

gtaattgttg cgacagtaaa agcaaagaat atgactagta tggcgggaat tcaggtaaat      120

attaaatatg accctgaagt attgcaggcg attgatcctg cgacgggaaa accgtttaca      180

aaagaaacat tacttgtgga cccggaactg ttatcaaaca gagaatataa tccgttgtta      240

acagcagtta atgacataaa ttccggcatt ataaattatg catcttgtta tgtatattgg      300

gattcctaca gagaatcagg agtatctgaa agcaccggaa taattggaaa ggttggcttt      360

aaagtgctga aagctgccaa caccacagta aaactggaag aaacaagatt tacaccaaat      420

tcgatagacg gtactttggt aattgattgg tatggccaac agatagttgg ttataaagta      480

atacagcccg acaaaattac tgtgatt                                          507


<210>  5
<211>  621
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  5

Met Ala Lys Ile Thr Phe Pro Lys Asp Phe Ile Trp Gly Ser Ala Thr 
1               5                   10                  15      


Ala Ala Tyr Gln Ile Glu Gly Ala Tyr Asn Glu Asp Gly Lys Gly Glu 
            20                  25                  30          


Ser Ile Trp Asp Arg Phe Ser His Thr Pro Gly Asn Ile Ala Asp Gly 
        35                  40                  45              


His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Glu Glu Asp 
    50                  55                  60                  


Ile Lys Ile Met Lys Glu Ile Gly Ile Lys Ser Tyr Arg Phe Ser Ile 
65                  70                  75                  80  


Ser Trp Pro Arg Ile Phe Pro Glu Gly Thr Gly Lys Leu Asn Gln Lys 
                85                  90                  95      


Gly Leu Asp Phe Tyr Lys Arg Leu Thr Asn Leu Leu Leu Glu Asn Gly 
            100                 105                 110         


Ile Met Pro Ala Ile Thr Leu Tyr His Trp Asp Leu Pro Gln Lys Leu 
        115                 120                 125             


Gln Asp Lys Gly Gly Trp Lys Asn Arg Asp Thr Thr Asp Tyr Phe Thr 
    130                 135                 140                 


Glu Tyr Ser Glu Val Ile Phe Lys Asn Leu Gly Asp Ile Val Pro Ile 
145                 150                 155                 160 


Trp Phe Thr His Asn Glu Pro Gly Val Val Ser Leu Leu Gly His Phe 
                165                 170                 175     


Leu Gly Ile His Ala Pro Gly Ile Lys Asp Leu Arg Thr Ser Leu Glu 
            180                 185                 190         


Val Ser His Asn Leu Leu Leu Ser His Gly Lys Ala Val Lys Leu Phe 
        195                 200                 205             


Arg Glu Met Asn Ile Asp Ala Gln Ile Gly Ile Ala Leu Asn Leu Ser 
    210                 215                 220                 


Tyr His Tyr Pro Ala Ser Glu Lys Ala Glu Asp Ile Glu Ala Ala Glu 
225                 230                 235                 240 


Leu Ser Phe Ser Leu Ala Gly Arg Trp Tyr Leu Asp Pro Val Leu Lys 
                245                 250                 255     


Gly Arg Tyr Pro Glu Asn Ala Leu Lys Leu Tyr Lys Lys Lys Gly Ile 
            260                 265                 270         


Glu Leu Ser Phe Pro Glu Asp Asp Leu Lys Leu Ile Ser Gln Pro Ile 
        275                 280                 285             


Asp Phe Ile Ala Phe Asn Asn Tyr Ser Ser Glu Phe Ile Lys Tyr Asp 
    290                 295                 300                 


Pro Ser Ser Glu Ser Gly Phe Ser Pro Ala Asn Ser Ile Leu Glu Lys 
305                 310                 315                 320 


Phe Glu Lys Thr Asp Met Gly Trp Ile Ile Tyr Pro Glu Gly Leu Tyr 
                325                 330                 335     


Asp Leu Leu Met Leu Leu Asp Arg Asp Tyr Gly Lys Pro Asn Ile Val 
            340                 345                 350         


Ile Ser Glu Asn Gly Ala Ala Phe Lys Asp Glu Ile Gly Ser Asn Gly 
        355                 360                 365             


Lys Ile Glu Asp Thr Lys Arg Ile Gln Tyr Leu Lys Asp Tyr Leu Thr 
    370                 375                 380                 


Gln Ala His Arg Ala Ile Gln Asp Gly Val Asn Leu Lys Ala Tyr Tyr 
385                 390                 395                 400 


Leu Trp Ser Leu Leu Asp Asn Phe Glu Trp Ala Tyr Gly Tyr Asn Lys 
                405                 410                 415     


Arg Phe Gly Ile Val His Val Asn Phe Asp Thr Leu Glu Arg Lys Ile 
            420                 425                 430         


Lys Asp Ser Gly Tyr Trp Tyr Lys Glu Val Ile Lys Asn Asn Gly Phe 
        435                 440                 445             


Gly Thr Leu Pro Asp Asp Ala His Ile Ala Leu Glu Leu Asp Lys Thr 
    450                 455                 460                 


Lys Val Lys Val Gly Asp Val Ile Val Ala Thr Val Lys Ala Lys Asn 
465                 470                 475                 480 


Met Thr Ser Met Ala Gly Ile Gln Val Asn Ile Lys Tyr Asp Pro Glu 
                485                 490                 495     


Val Leu Gln Ala Ile Asp Pro Ala Thr Gly Lys Pro Phe Thr Lys Glu 
            500                 505                 510         


Thr Leu Leu Val Asp Pro Glu Leu Leu Ser Asn Arg Glu Tyr Asn Pro 
        515                 520                 525             


Leu Leu Thr Ala Val Asn Asp Ile Asn Ser Gly Ile Ile Asn Tyr Ala 
    530                 535                 540                 


Ser Cys Tyr Val Tyr Trp Asp Ser Tyr Arg Glu Ser Gly Val Ser Glu 
545                 550                 555                 560 


Ser Thr Gly Ile Ile Gly Lys Val Gly Phe Lys Val Leu Lys Ala Ala 
                565                 570                 575     


Asn Thr Thr Val Lys Leu Glu Glu Thr Arg Phe Thr Pro Asn Ser Ile 
            580                 585                 590         


Asp Gly Thr Leu Val Ile Asp Trp Tyr Gly Gln Gln Ile Val Gly Tyr 
        595                 600                 605             


Lys Val Ile Gln Pro Asp Lys Ile Thr Val Ile Leu Glu 
    610                 615                 620     


<210>  6
<211>  1863
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  6
atggcaaaga taactttccc aaaagatttc atatggggtt ctgcaacagc agcatatcag       60

attgaaggtg catacaacga agacggcaaa ggtgaatcta tatgggaccg tttttcccac      120

acgccaggaa atatagcaga cggacatacc ggcgatgttg catgcgacca ctatcatcgt      180

tatgaagaag atatcaaaat aatgaaagaa atcggtatta aatcatacag gttttccatc      240

tcatggccca gaatctttcc tgaaggaaca ggtaaattaa atcaaaaggg actggatttt      300

tacaaaaggc tcacaaatct gcttctggaa aacggaatta tgcctgcaat cactctttat      360

cactgggacc ttccccaaaa gcttcaggat aaaggcggat ggaaaaaccg ggacaccacc      420

gattatttta cagaatactc tgaagtaata tttaaaaatc tcggagatat cgttccaata      480

tggtttactc acaatgaacc cggtgttgtt tctttgcttg gccacttttt aggaattcat      540

gcccctggga taaaagacct ccgcacttca ttggaagtct cgcacaatct tcttttgtcc      600

cacggcaagg ccgtgaaact gtttagagaa atgaatattg acgcccaaat tggaatagct      660

ctcaatttat cttaccatta tcccgcatcc gaaaaagctg aggatattga agcagcggaa      720

ttgtcatttt ctctggcggg aaggtggtat ctggatcctg tgctaaaagg ccggtatcct      780

gaaaacgcat tgaaacttta taaaaagaag ggtattgagc tttctttccc tgaagatgac      840

ctgaaactta tcagtcagcc aatagacttc atagcattca acaattattc ttcggaattt      900

ataaaatatg atccgtccag tgagtcaggt ttttcacctg caaactccat attagaaaag      960

ttcgaaaaaa cagatatggg ctggatcata tatcctgaag gcttgtatga tctgcttatg     1020

ctccttgaca gggattatgg aaagccaaac attgttatca gcgaaaacgg agccgccttc     1080

aaagatgaaa taggtagcaa cggaaagata gaagacacaa agagaatcca atatcttaaa     1140

gattatctga cccaggctca cagggcaatt caggacggtg taaacttaaa agcatactac     1200

ttgtggtcgc ttttggacaa ctttgaatgg gcttacgggt acaacaagag attcggaatc     1260

gttcacgtaa attttgatac gttggaaaga aaaataaagg atagcggcta ctggtacaaa     1320

gaagtaatca aaaacaacgg tttcggtacc ttaccggacg atgcacacat tgctttggaa     1380

cttgacaaga caaaagtgaa agtgggagat gtaattgttg cgacagtaaa agcaaagaat     1440

atgactagta tggcgggaat tcaggtaaat attaaatatg accctgaagt attgcaggcg     1500

attgatcctg cgacgggaaa accgtttaca aaagaaacat tacttgtgga cccggaactg     1560

ttatcaaaca gagaatataa tccgttgtta acagcagtta atgacataaa ttccggcatt     1620

ataaattatg catcttgtta tgtatattgg gattcctaca gagaatcagg agtatctgaa     1680

agcaccggaa taattggaaa ggttggcttt aaagtgctga aagctgccaa caccacagta     1740

aaactggaag aaacaagatt tacaccaaat tcgatagacg gtactttggt aattgattgg     1800

tatggccaac agatagttgg ttataaagta atacagcccg acaaaattac tgtgattctc     1860

gag                                                                   1863


<210>  7
<211>  411
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  7

Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
1               5                   10                  15      


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
            20                  25                  30          


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
        35                  40                  45              


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 
    50                  55                  60                  


Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Arg 
65                  70                  75                  80  


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
                85                  90                  95      


Thr Ile Ser Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
            100                 105                 110         


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
        115                 120                 125             


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
    130                 135                 140                 


Tyr Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly 
145                 150                 155                 160 


Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val 
                165                 170                 175     


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
            180                 185                 190         


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser 
        195                 200                 205             


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
    210                 215                 220                 


Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys Gly Thr 
225                 230                 235                 240 


Leu Pro Asp Asp Ala His Ile Ala Leu Glu Leu Asp Lys Thr Lys Val 
                245                 250                 255     


Lys Val Gly Asp Val Ile Val Ala Thr Val Lys Ala Lys Asn Met Thr 
            260                 265                 270         


Ser Met Ala Gly Ile Gln Val Asn Ile Lys Tyr Asp Pro Glu Val Leu 
        275                 280                 285             


Gln Ala Ile Asp Pro Ala Thr Gly Lys Pro Phe Thr Lys Glu Thr Leu 
    290                 295                 300                 


Leu Val Asp Pro Glu Leu Leu Ser Asn Arg Glu Tyr Asn Pro Leu Leu 
305                 310                 315                 320 


Thr Ala Val Asn Asp Ile Asn Ser Gly Ile Ile Asn Tyr Ala Ser Cys 
                325                 330                 335     


Tyr Val Tyr Trp Asp Ser Tyr Arg Glu Ser Gly Val Ser Glu Ser Thr 
            340                 345                 350         


Gly Ile Ile Gly Lys Val Gly Phe Lys Val Leu Lys Ala Ala Asn Thr 
        355                 360                 365             


Thr Val Lys Leu Glu Glu Thr Arg Phe Thr Pro Asn Ser Ile Asp Gly 
    370                 375                 380                 


Thr Leu Val Ile Asp Trp Tyr Gly Gln Gln Ile Val Gly Tyr Lys Val 
385                 390                 395                 400 


Ile Gln Pro Asp Lys Ile Thr Val Ile Leu Glu 
                405                 410     


<210>  8
<211>  1233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  8
atgagtaaag gagaagaact tttcactgga gttgtcccaa ttcttgttga attagatggt       60

gatgttaatg ggcacaaatt ttctgtcagt ggagagggtg aaggtgatgc aacatacgga      120

aaacttaccc ttaaatttat ttgcactact ggaaaactac ctgttccatg gccaacactt      180

gtcactactc tgacgtatgg tgttcaatgc ttttcccgtt atccggatca catgaaacgg      240

catgactttt tcaagagtgc catgcccgaa ggttatgtac aggaacgcac tatatctttc      300

aaagatgacg ggaactacaa gacgcgtgct gaagtcaagt ttgaaggtga tacccttgtt      360

aatcgtatcg agttaaaagg tattgatttt aaagaagatg gaaacattct cggacacaaa      420

ctcgagtaca actataactc acacaatgta tacatcacgg cagacaaaca aaagaatgga      480

atcaaagcta acttcaaaat tcgccacaac attgaagatg gatccgttca actagcagac      540

cattatcaac aaaatactcc aattggcgat ggccctgtcc ttttaccaga caaccattac      600

ctgtcgacac aatctgccct ttcgaaagat cccaacgaaa agcgtgacca catggtcctt      660

cttgagtttg taactgctgc tgggattaca catggcatgg atgagctcta caaaggtacc      720

ttaccggacg atgcacacat tgctttggaa cttgacaaga caaaagtgaa agtgggagat      780

gtaattgttg cgacagtaaa agcaaagaat atgactagta tggcgggaat tcaggtaaat      840

attaaatatg accctgaagt attgcaggcg attgatcctg cgacgggaaa accgtttaca      900

aaagaaacat tacttgtgga cccggaactg ttatcaaaca gagaatataa tccgttgtta      960

acagcagtta atgacataaa ttccggcatt ataaattatg catcttgtta tgtatattgg     1020

gattcctaca gagaatcagg agtatctgaa agcaccggaa taattggaaa ggttggcttt     1080

aaagtgctga aagctgccaa caccacagta aaactggaag aaacaagatt tacaccaaat     1140

tcgatagacg gtactttggt aattgattgg tatggccaac agatagttgg ttataaagta     1200

atacagcccg acaaaattac tgtgattctc gag                                  1233


<210>  9
<211>  550
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  9

Met Ala Lys Ile Thr Phe Pro Lys Asp Phe Ile Trp Gly Ser Ala Thr 
1               5                   10                  15      


Ala Ala Tyr Gln Ile Glu Gly Ala Tyr Asn Glu Asp Gly Lys Gly Glu 
            20                  25                  30          


Ser Ile Trp Asp Arg Phe Ser His Thr Pro Gly Asn Ile Ala Asp Gly 
        35                  40                  45              


His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Glu Glu Asp 
    50                  55                  60                  


Ile Lys Ile Met Lys Glu Ile Gly Ile Lys Ser Tyr Arg Phe Ser Ile 
65                  70                  75                  80  


Ser Trp Pro Arg Ile Phe Pro Glu Gly Thr Gly Lys Leu Asn Gln Lys 
                85                  90                  95      


Gly Leu Asp Phe Tyr Lys Arg Leu Thr Asn Leu Leu Leu Glu Asn Gly 
            100                 105                 110         


Ile Met Pro Ala Ile Thr Leu Tyr His Trp Asp Leu Pro Gln Lys Leu 
        115                 120                 125             


Gln Asp Lys Gly Gly Trp Lys Asn Arg Asp Thr Thr Asp Tyr Phe Thr 
    130                 135                 140                 


Glu Tyr Ser Glu Val Ile Phe Lys Asn Leu Gly Asp Ile Val Pro Ile 
145                 150                 155                 160 


Trp Phe Thr His Asn Glu Pro Gly Val Val Ser Leu Leu Gly His Phe 
                165                 170                 175     


Leu Gly Ile His Ala Pro Gly Ile Lys Asp Leu Arg Thr Ser Leu Glu 
            180                 185                 190         


Val Ser His Asn Leu Leu Leu Ser His Gly Lys Ala Val Lys Leu Phe 
        195                 200                 205             


Arg Glu Met Asn Ile Asp Ala Gln Ile Gly Ile Ala Leu Asn Leu Ser 
    210                 215                 220                 


Tyr His Tyr Pro Ala Ser Glu Lys Ala Glu Asp Ile Glu Ala Ala Glu 
225                 230                 235                 240 


Leu Ser Phe Ser Leu Ala Gly Arg Trp Tyr Leu Asp Pro Val Leu Lys 
                245                 250                 255     


Gly Arg Tyr Pro Glu Asn Ala Leu Lys Leu Tyr Lys Lys Lys Gly Ile 
            260                 265                 270         


Glu Leu Ser Phe Pro Glu Asp Asp Leu Lys Leu Ile Ser Gln Pro Ile 
        275                 280                 285             


Asp Phe Ile Ala Phe Asn Asn Tyr Ser Ser Glu Phe Ile Lys Tyr Asp 
    290                 295                 300                 


Pro Ser Ser Glu Ser Gly Phe Ser Pro Ala Asn Ser Ile Leu Glu Lys 
305                 310                 315                 320 


Phe Glu Lys Thr Asp Met Gly Trp Ile Ile Tyr Pro Glu Gly Leu Tyr 
                325                 330                 335     


Asp Leu Leu Met Leu Leu Asp Arg Asp Tyr Gly Lys Pro Asn Ile Val 
            340                 345                 350         


Ile Ser Glu Asn Gly Ala Ala Phe Lys Asp Glu Ile Gly Ser Asn Gly 
        355                 360                 365             


Lys Ile Glu Asp Thr Lys Arg Ile Gln Tyr Leu Lys Asp Tyr Leu Thr 
    370                 375                 380                 


Gln Ala His Arg Ala Ile Gln Asp Gly Val Asn Leu Lys Ala Tyr Tyr 
385                 390                 395                 400 


Leu Trp Ser Leu Leu Asp Asn Phe Glu Trp Ala Tyr Gly Tyr Asn Lys 
                405                 410                 415     


Arg Phe Gly Ile Val His Val Asn Phe Asp Thr Leu Glu Arg Lys Ile 
            420                 425                 430         


Lys Asp Ser Gly Tyr Trp Tyr Lys Glu Val Ile Lys Asn Asn Gly Phe 
        435                 440                 445             


Gly Thr Gly Val Glu Ser Ser Ser Thr Gly Leu Gly Asp Leu Asn Gly 
    450                 455                 460                 


Asp Gly Asn Ile Asn Ser Ser Asp Leu Gln Ala Leu Lys Arg His Leu 
465                 470                 475                 480 


Leu Gly Ile Ser Pro Leu Thr Gly Glu Ala Leu Leu Arg Ala Asp Val 
                485                 490                 495     


Asn Arg Ser Gly Lys Val Asp Ser Thr Asp Tyr Ser Val Leu Lys Arg 
            500                 505                 510         


Tyr Ile Leu Arg Ile Ile Thr Glu Phe Pro Gly Gln Gly Asp Val Gln 
        515                 520                 525             


Thr Pro Asn Pro Ser Val Thr Pro Thr Gln Thr Pro Ile Pro Thr Ile 
    530                 535                 540                 


Ser Gly Asn Ala Leu Glu 
545                 550 


<210>  10
<211>  1650
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  10
atggcaaaga taactttccc aaaagatttc atatggggtt ctgcaacagc agcatatcag       60

attgaaggtg catacaacga agacggcaaa ggtgaatcta tatgggaccg tttttcccac      120

acgccaggaa atatagcaga cggacatacc ggcgatgttg catgcgacca ctatcatcgt      180

tatgaagaag atatcaaaat aatgaaagaa atcggtatta aatcatacag gttttccatc      240

tcatggccca gaatctttcc tgaaggaaca ggtaaattaa atcaaaaggg actggatttt      300

tacaaaaggc tcacaaatct gcttctggaa aacggaatta tgcctgcaat cactctttat      360

cactgggacc ttccccaaaa gcttcaggat aaaggcggat ggaaaaaccg ggacaccacc      420

gattatttta cagaatactc tgaagtaata tttaaaaatc tcggagatat cgttccaata      480

tggtttactc acaatgaacc cggtgttgtt tctttgcttg gccacttttt aggaattcat      540

gcccctggga taaaagacct ccgcacttca ttggaagtct cgcacaatct tcttttgtcc      600

cacggcaagg ccgtgaaact gtttagagaa atgaatattg acgcccaaat tggaatagct      660

ctcaatttat cttaccatta tcccgcatcc gaaaaagctg aggatattga agcagcggaa      720

ttgtcatttt ctctggcggg aaggtggtat ctggatcctg tgctaaaagg ccggtatcct      780

gaaaacgcat tgaaacttta taaaaagaag ggtattgagc tttctttccc tgaagatgac      840

ctgaaactta tcagtcagcc aatagacttc atagcattca acaattattc ttcggaattt      900

ataaaatatg atccgtccag tgagtcaggt ttttcacctg caaactccat attagaaaag      960

ttcgaaaaaa cagatatggg ctggatcata tatcctgaag gcttgtatga tctgcttatg     1020

ctccttgaca gggattatgg aaagccaaac attgttatca gcgaaaacgg agccgccttc     1080

aaagatgaaa taggtagcaa cggaaagata gaagacacaa agagaatcca atatcttaaa     1140

gattatctga cccaggctca cagggcaatt caggacggtg taaacttaaa agcatactac     1200

ttgtggtcgc ttttggacaa ctttgaatgg gcttacgggt acaacaagag attcggaatc     1260

gttcacgtaa attttgatac gttggaaaga aaaataaagg atagcggcta ctggtacaaa     1320

gaagtaatca aaaacaacgg tttcggtacc ggcgttgaaa gcagttccac aggtctgggg     1380

gatttaaatg gtgacggaaa tattaactcg tcggaccttc aggcgttaaa gaggcatttg     1440

ctcggtatat caccgcttac gggagaggct cttttaagag cggatgtaaa taggagcggc     1500

aaagtggatt ctactgacta ttcagtgctg aaaagatata tactccgcat tattacagag     1560

ttccccggac aaggtgatgt acagacaccc aatccgtctg ttactccgac acaaactcct     1620

atccccacga tttcgggaaa tgctctcgag                                      1650


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  11
cagtccatgg caaagataac                                                   20


<210>  12
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  12
cacgctcgag gaaaccgttg tttttgatta c                                      31


<210>  13
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  13
catgggtacc gaaaccgttg tttttgatta c                                      31


<210>  14
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  14
gtttcggtac cttaccggac gatgcacaca t                                      31


<210>  15
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  15
tggtgctcga gaatcacagt aatt                                              24


<210>  16
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  16
cacctcatga gtaaaggaga agaactt                                           27


<210>  17
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  17
ggtaaggtac ctttgtagag ctcatccatg c                                      31


