                         SEQUENCE LISTING

<110>  CSL Behring GmbH et al
 
<120>  Factor XII inhibitors for the treatment of neurological 
       inflammatory disorders

<130>  A189

<140>  EP2012153341.8
<141>  2012-01-31

<160>  19    

<170>  PatentIn version 3.3

<210>  1
<211>  409
<212>  PRT
<213>  Triatoma infestans

<400>  1

Met Arg Tyr Leu Leu Leu Leu Gly Leu Ala Ala Phe Ser Ala Val Ser 
1               5                   10                  15      


Ala Glu Lys Lys Asp Pro Pro Cys Val Cys Pro Leu Ile Trp Lys Pro 
            20                  25                  30          


Val Cys Gly Ser Asp Gly Gln Thr Tyr Pro Ser Glu Cys Ile Leu Asn 
        35                  40                  45              


Cys Val Lys Tyr Ala Leu Lys Lys Asp Ile Lys Val Ala Tyr Gln Gly 
    50                  55                  60                  


Ile Cys Lys His Val Thr Phe Ala Ala Glu Glu Glu Gln Glu Val Glu 
65                  70                  75                  80  


Gly Trp Lys Gly Pro Cys Glu Cys Pro Arg Ala Leu His Arg Val Cys 
                85                  90                  95      


Gly Ser Asp Gly Asn Thr Tyr Ser Asn Pro Cys Thr Leu Asn Cys Ala 
            100                 105                 110         


Lys His Glu Arg Lys Ser Asp Leu Val Gln Val His Glu Gly Pro Cys 
        115                 120                 125             


Ser Pro Asp Glu His Glu Phe Glu Asp Pro Cys Glu Cys Asp Asn Lys 
    130                 135                 140                 


Phe Asp Pro Val Cys Gly Thr Gly Glu Val Thr Tyr Arg Asn Leu Cys 
145                 150                 155                 160 


His Leu Glu Cys Ala Thr Phe Thr Thr Ser Pro Gly Val Glu Val Asp 
                165                 170                 175     


Tyr Glu Gly Glu Cys Leu Ala Glu Thr Val Leu Leu Glu Glu Asn His 
            180                 185                 190         


Cys Ala Cys Pro Arg Val Leu His Arg Val Cys Gly Ser Asp Gly Asn 
        195                 200                 205             


Thr Tyr Ser Asn Pro Cys Thr Leu Asp Cys Ala Lys His Glu Gly Lys 
    210                 215                 220                 


Pro Asp Leu Val Gln Val His Glu Gly Pro Cys Asp Pro Asn Asp His 
225                 230                 235                 240 


Asp Phe Glu Asp Pro Cys Glu Cys Asp Asn Lys Phe Glu Pro Val Cys 
                245                 250                 255     


Gly Thr Asp His Ile Thr Tyr Ser Asn Leu Cys His Leu Glu Cys Ala 
            260                 265                 270         


Ala Phe Thr Thr Ser Pro Gly Val Glu Val Lys Tyr Glu Gly Glu Cys 
        275                 280                 285             


His Ala Glu Ile Met Glu Gln His Gln Ile Leu Lys Ser Cys Ile Cys 
    290                 295                 300                 


Thr Lys Met Tyr Lys Pro Val Cys Gly Thr Asp Gly His Thr Tyr Pro 
305                 310                 315                 320 


Asn Leu Cys Val Leu Lys Cys Arg Ile Ser Ser Lys Pro Gly Leu Lys 
                325                 330                 335     


Leu Ala His Val Gly Lys Cys Gly Ile Gly Leu Leu Ala Val Glu Thr 
            340                 345                 350         


Lys Glu Val Arg Asn Pro Cys Ala Cys Phe Arg Asn Tyr Val Pro Val 
        355                 360                 365             


Cys Gly Ser Asp Gly Lys Thr Tyr Gly Asn Pro Cys Met Leu Asn Cys 
    370                 375                 380                 


Ala Ala Gln Thr Lys Val Pro Gly Leu Lys Leu Val His Lys Gly Arg 
385                 390                 395                 400 


Cys Gln Arg Ser Asp Val Glu Gln Phe 
                405                 


<210>  2
<211>  48
<212>  PRT
<213>  Triatoma infestans

<400>  2

Glu Val Arg Asn Pro Cys Ala Cys Phe Arg Asn Tyr Val Pro Val Cys 
1               5                   10                  15      


Gly Ser Asp Gly Lys Thr Tyr Gly Asn Pro Cys Met Leu Asn Cys Ala 
            20                  25                  30          


Ala Gln Thr Lys Val Pro Gly Leu Lys Leu Val His Glu Gly Arg Cys 
        35                  40                  45              


<210>  3
<211>  56
<212>  PRT
<213>  Homo sapiens

<400>  3

Asp Ser Leu Gly Arg Glu Ala Lys Cys Tyr Asn Glu Leu Asn Gly Cys 
1               5                   10                  15      


Thr Lys Ile Tyr Asp Pro Val Cys Gly Thr Asp Gly Asn Thr Tyr Pro 
            20                  25                  30          


Asn Glu Cys Val Leu Cys Phe Glu Asn Arg Lys Arg Gln Thr Ser Ile 
        35                  40                  45              


Leu Ile Gln Lys Ser Gly Pro Cys 
    50                  55      


<210>  4
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  4

Asp Ser Leu Gly Arg Glu Val Arg Asn Pro Cys Ala Cys Phe Arg Asn 
1               5                   10                  15      


Tyr Val Pro Val Cys Gly Thr Asp Gly Asn Thr Tyr Pro Asn Glu Cys 
            20                  25                  30          


Val Leu Cys Phe Glu Asn Arg Lys Arg Gln Thr Ser Ile Leu Ile Gln 
        35                  40                  45              


Lys Ser Gly Pro Cys 
    50              


<210>  5
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  5

Asp Ser Leu Gly Arg Glu Val Arg Asn Pro Cys Ala Cys Phe Arg Asn 
1               5                   10                  15      


Tyr Val Pro Val Cys Gly Thr Asp Gly Asn Thr Tyr Gly Asn Glu Cys 
            20                  25                  30          


Met Leu Cys Ala Glu Asn Arg Lys Arg Gln Thr Ser Ile Leu Ile Gln 
        35                  40                  45              


Lys Glu Gly Pro Cys 
    50              


<210>  6
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  6

Asp Ser Leu Gly Arg Glu Val Arg Asn Pro Cys Ala Cys Phe Arg Asn 
1               5                   10                  15      


Tyr Val Pro Val Cys Gly Thr Asp Gly Asn Thr Tyr Gly Asn Glu Cys 
            20                  25                  30          


Met Leu Asn Cys Ala Glu Asn Arg Lys Arg Gln Thr Ser Ile Leu Ile 
        35                  40                  45              


Gln Lys Glu Gly Pro Cys 
    50                  


<210>  7
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  7

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Tyr 
            20                  25                  30          


Ile Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Arg Pro Ser Gly Gly Thr Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Leu Pro Arg Ser Gly Tyr Leu Ile Ser Pro His Tyr Tyr 
            100                 105                 110         


Tyr Tyr Ala Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  8
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  8

Gln Ser Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Arg Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Val Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Val Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser Leu 
                85                  90                  95      


Arg Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110 


<210>  9
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  9

Lys Tyr Ile Met Gln 
1               5   


<210>  10
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  10

Gly Ile Arg Pro Ser Gly Gly Thr Thr Val Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  11
<211>  17
<212>  PRT
<213>  Artificial


<220>
<223>  Heavy chain CDR2 showing variations

<220>  
<221>  variant
<222>  (3)..(3)
<223>  Xaa is selected from Arg, Asn, and Asp

<220>  
<221>  variant
<222>  (4)..(4)
<223>  Xaa is selected from Pro, Val, Ile and Met

<220>  
<221>  variant
<222>  (5)..(5)
<223>  Xaa is selected from Ser, Pro and Ala

<220>  
<221>  variant
<222>  (6)..(6)
<223>  Xaa is selected from Gly, Leu, Val and Thr

<220>  
<221>  variant
<222>  (7)..(7)
<223>  Xaa is selected from Gly, Tyr, Gln, Lys, Arg, Asn and Met

<220>  
<221>  variant
<222>  (8)..(8)
<223>  Xaa is selected from Thr, Gly and Ser



<400>  11

Gly Ile Xaa Xaa Xaa Xaa Xaa Xaa Thr Val Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  12
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  12

Ala Leu Pro Arg Ser Gly Tyr Leu Ile Ser Pro His Tyr Tyr Tyr Tyr 
1               5                   10                  15      


Ala Leu Asp Val 
            20  


<210>  13
<211>  20
<212>  PRT
<213>  Artificial


<220>
<223>  Heavy chain CDR3 showing variations

<220>  
<221>  variant
<222>  (9)..(9)
<223>  Xaa is selected from Ala, Met and Val

<220>  
<221>  variant
<222>  (10)..(10)
<223>  Xaa is selected from Ser and Lys

<220>  
<221>  variant
<222>  (11)..(11)
<223>  Xaa is selected from Pro, Lys, Thr and His

<220>  
<221>  variant
<222>  (12)..(12)
<223>  Xaa is selected from His, Asn, Gly and Gln

<400>  13

Ala Leu Pro Arg Ser Gly Tyr Leu Xaa Xaa Xaa Xaa Tyr Tyr Tyr Tyr 
1               5                   10                  15      


Ala Leu Asp Val 
            20  


<210>  14
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  14

Ser Gly Ser Ser Ser Asn Ile Gly Arg Asn Tyr Val Tyr 
1               5                   10              


<210>  15
<211>  7
<212>  PRT
<213>  Homo Sapiens

<400>  15

Ser Asn Asn Gln Arg Pro Ser 
1               5           


<210>  16
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  16

Ala Ala Trp Asp Ala Ser Leu Arg Gly Val 
1               5                   10  


<210>  17
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>  
<221>  variant
<222>  (2)..(2)
<223>  Xaa is selected from Ala and Ser

<220>  
<221>  variant
<222>  (4)..(6)
<223>  Xaa can be any amino acid

<220>  
<221>  variant
<222>  (7)..(7)
<223>  Xaa is selected from Leu and Val

<220>  
<221>  variant
<222>  (9)..(10)
<223>  Xaa can be any amino acid

<400>  17

Ala Xaa Trp Xaa Xaa Xaa Xaa Arg Xaa Xaa 
1               5                   10  


<210>  18
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  18

Ser Gly Ser Ser Glu Met Thr Val His His Tyr Val Tyr 
1               5                   10              


<210>  19
<211>  585
<212>  PRT
<213>  Homo sapiens

<400>  19

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Lys Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585 


