                         SEQUENCE LISTING

<110>  VIB VZW
       KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D
 
<120>  Means and method for diagnosis and treatment of Alzheimer's 
       disease

<130>  BDS/TSP6/405

<150>  US 61/592,412
<151>  2012-01-30

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  2036
<212>  DNA
<213>  Homo sapiens

<400>  1
gggactccgc gtctcgctct ctgtgttcca atcgcccggt gcggtggtgc agggtctcgg       60

gctagtcatg gcgtccccgt ctcggagact gcagactaaa ccagtcatta cttgtttcaa      120

gagcgttctg ctaatctaca cttttatttt ctggatcact ggcgttatcc ttcttgcagt      180

tggcatttgg ggcaaggtga gcctggagaa ttacttttct cttttaaatg agaaggccac      240

caatgtcccc ttcgtgctaa ttgctactgg taccgtcatt attcttttgg gcacctttgg      300

ttgttttgct acctgccgag cttctgcatg gatgctaaaa ctgtatgcaa tgtttctgac      360

tctcgttttt ttggtcgaac tggtcgctgc catcgtagga tttgttttca gacatgagat      420

taagaacagc tttaagaata attatgagaa ggctttgaag cagtataact ctacaggaga      480

ttatagaagc catgcagtag acaagatcca aaatacgttg cattgttgtg gtgtcaccga      540

ttatagagat tggacagata ctaattatta ctcagaaaaa ggatttccta agagttgctg      600

taaacttgaa gattgtactc cacagagaga tgcagacaaa gtaaacaatg aaggttgttt      660

tataaaggtg atgaccatta tagagtcaga aatgggagtc gttgcaggaa tttcctttgg      720

agttgcttgc ttccaactga ttggaatctt tctcgcctac tgcctctctc gtgccataac      780

aaataaccag tatgagatag tgtaacccaa tgtatctgtg ggcctattcc tctctacctt      840

taaggacatt taggtccccc ctgtgaatta gaaagttgct tggctggaga actgacagca      900

ctacttactg atagaccaaa aaactacacc agtaggttga ttcaatcaag atgtatgtag      960

acctaaaact acaccaatag gctgattcaa tcaagatccg tgctcgcagt gggctgattc     1020

aatcaagatg tatgtttgct atgttctaag tccaccttct atcccattca tgttagatcg     1080

ttgaaacctg gtctccctct gaaacactgg aagagctagt aaattgtaaa tgaagtaata     1140

ctgtgttcct cttgactgtt atttttctta gtagggggcc tttggaaggc actgtgaatt     1200

tgctattttg atgtagtgtt accaagatgg aaaattgatt cctctgactt tgctattgat     1260

gtagtgtgat agaaaattca cccctctgaa ctggctcctt cccagtcaag gttatctggt     1320

ttgattgtat aatttgcacc aagaagttaa aatgttttat gactctctgt tctgctgaca     1380

ggcagagagt cacattgtgt aatttaattt cagtcagtca atagatggca tccctcatca     1440

gggttgccag atggtgataa cagtgtaagg ccttgggtct aaggcatcca cgactggaag     1500

ggactactga tgttctgtga tacatcaggt ttcagcacac aacttacatt tctttgcctc     1560

caaattgagg catttattat gatgttcata ctttccctct tgtttgaaag tttctaatta     1620

ttaaatggtg tcggaattgt tgtattttcc ttaggaattc agtggaactt atcttcatta     1680

aatttagctg gtaccaggtt gatatgactt gtcaatatta tggtcaactt taagtcttag     1740

ttttcgtttg tgcctttgat taataagtat aactcttata caataaatac tgctttcctc     1800

taaaaagatc gtgtttaaat taacttgtag aaaatctgct ggaatggttg ttgttttcca     1860

ctgagaaagc taagccctac atttctattc agagtactgt ttttagatgt gaaatataag     1920

cctgcggcct taactctgta ttaaaaaaaa tgtttttgtt taaaaaaaac tgttcccata     1980

ggtgcagcaa accaccatgg cacatgtata cctatgtaac aaacctgcac attttg         2036


<210>  2
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ser Pro Ser Arg Arg Leu Gln Thr Lys Pro Val Ile Thr Cys 
1               5                   10                  15      


Phe Lys Ser Val Leu Leu Ile Tyr Thr Phe Ile Phe Trp Ile Thr Gly 
            20                  25                  30          


Val Ile Leu Leu Ala Val Gly Ile Trp Gly Lys Val Ser Leu Glu Asn 
        35                  40                  45              


Tyr Phe Ser Leu Leu Asn Glu Lys Ala Thr Asn Val Pro Phe Val Leu 
    50                  55                  60                  


Ile Ala Thr Gly Thr Val Ile Ile Leu Leu Gly Thr Phe Gly Cys Phe 
65                  70                  75                  80  


Ala Thr Cys Arg Ala Ser Ala Trp Met Leu Lys Leu Tyr Ala Met Phe 
                85                  90                  95      


Leu Thr Leu Val Phe Leu Val Glu Leu Val Ala Ala Ile Val Gly Phe 
            100                 105                 110         


Val Phe Arg His Glu Ile Lys Asn Ser Phe Lys Asn Asn Tyr Glu Lys 
        115                 120                 125             


Ala Leu Lys Gln Tyr Asn Ser Thr Gly Asp Tyr Arg Ser His Ala Val 
    130                 135                 140                 


Asp Lys Ile Gln Asn Thr Leu His Cys Cys Gly Val Thr Asp Tyr Arg 
145                 150                 155                 160 


Asp Trp Thr Asp Thr Asn Tyr Tyr Ser Glu Lys Gly Phe Pro Lys Ser 
                165                 170                 175     


Cys Cys Lys Leu Glu Asp Cys Thr Pro Gln Arg Asp Ala Asp Lys Val 
            180                 185                 190         


Asn Asn Glu Gly Cys Phe Ile Lys Val Met Thr Ile Ile Glu Ser Glu 
        195                 200                 205             


Met Gly Val Val Ala Gly Ile Ser Phe Gly Val Ala Cys Phe Gln Leu 
    210                 215                 220                 


Ile Gly Ile Phe Leu Ala Tyr Cys Leu Ser Arg Ala Ile Thr Asn Asn 
225                 230                 235                 240 


Gln Tyr Glu Ile Val 
                245 


<210>  3
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  3

Arg His Glu Ile Lys Asn Ser Phe Lys Asn Asn Tyr Glu Lys Ala Leu 
1               5                   10                  15      


Lys Gln Tyr Asn Ser Thr Gly Asp Tyr Arg Ser His Ala Val Asp Lys 
            20                  25                  30          


Ile Gln Asn Thr Leu His Cys Cys Gly Val Thr Asp Tyr Arg Asp Trp 
        35                  40                  45              


Thr Asp Thr Asn Tyr Tyr Ser Glu Lys Gly Phe Pro Lys Ser Cys Cys 
    50                  55                  60                  


Lys Leu Glu Asp Cys Thr Pro Gln Arg Asp Ala Asp Lys Val Asn Asn 
65                  70                  75                  80  


Glu Gly Cys Phe Ile Lys Val Met Thr Ile Ile Glu Ser Glu Met 
                85                  90                  95  


<210>  4
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide derived from Rabies virus and coupled to a poly-Arginine 
       stretch

<400>  4

Tyr Thr Ile Trp Met Pro Glu Asn Pro Arg Pro Gly Thr Pro Cys Asp 
1               5                   10                  15      


Ile Phe Thr Asn Ser Arg Gly Lys Arg Ala Ser Asn Gly Gly Gly Gly 
            20                  25                  30          


Arg Arg Arg Arg Arg Arg Arg Arg Arg 
        35                  40      


<210>  5
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ligand

<400>  5

Tyr Thr Ile Trp Met Pro Glu Asn Pro Arg Pro Gly Thr Pro Cys Asp 
1               5                   10                  15      


Ile Phe Thr Asn Ser Arg Gly Lys Arg Ala Ser Asn Gly 
            20                  25                  


