                         SEQUENCE LISTING

<110>  THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
 
<120>  DIAGNOSIS AND TREATMENT FOR RESPIRATORY TRACT DISEASES

<130>  P-76262-PC

<140>  PCT/US13/999999
<141>  2013-01-14

<150>  61/591,425
<151>  2012-01-27

<150>  61/697,652
<151>  2012-09-06

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Leu Thr Leu Thr Arg Ile Arg Thr Val Ser Tyr Glu Val Arg Ser 
1               5                   10                  15      


Thr Phe Leu Phe Ile Ser Val Leu Glu Phe Ala Val Gly Phe Leu Thr 
            20                  25                  30          


Asn Ala Phe Val Phe Leu Val Asn Phe Trp Asp Val Val Lys Arg Gln 
        35                  40                  45              


Ala Leu Ser Asn Ser Asp Cys Val Leu Leu Cys Leu Ser Ile Ser Arg 
    50                  55                  60                  


Leu Phe Leu His Gly Leu Leu Phe Leu Ser Ala Ile Gln Leu Thr His 
65                  70                  75                  80  


Phe Gln Lys Leu Ser Glu Pro Leu Asn His Ser Tyr Gln Ala Ile Ile 
                85                  90                  95      


Met Leu Trp Met Ile Ala Asn Gln Ala Asn Leu Trp Leu Ala Ala Cys 
            100                 105                 110         


Leu Ser Leu Leu Tyr Cys Ser Lys Leu Ile Arg Phe Ser His Thr Phe 
        115                 120                 125             


Leu Ile Cys Leu Ala Ser Trp Val Ser Arg Lys Ile Ser Gln Met Leu 
    130                 135                 140                 


Leu Gly Ile Ile Leu Cys Ser Cys Ile Cys Thr Val Leu Cys Val Trp 
145                 150                 155                 160 


Cys Phe Phe Ser Arg Pro His Phe Thr Val Thr Thr Val Leu Phe Met 
                165                 170                 175     


Asn Asn Asn Thr Arg Leu Asn Trp Gln Ile Lys Asp Leu Asn Leu Phe 
            180                 185                 190         


Tyr Ser Phe Leu Phe Cys Tyr Leu Trp Ser Val Pro Pro Phe Leu Leu 
        195                 200                 205             


Phe Leu Val Ser Ser Gly Met Leu Thr Val Ser Leu Gly Arg His Met 
    210                 215                 220                 


Arg Thr Met Lys Val Tyr Thr Arg Asn Ser Arg Asp Pro Ser Leu Glu 
225                 230                 235                 240 


Ala His Ile Lys Ala Leu Lys Ser Leu Val Ser Phe Phe Cys Phe Phe 
                245                 250                 255     


Val Ile Ser Ser Cys Val Ala Phe Ile Ser Val Pro Leu Leu Ile Leu 
            260                 265                 270         


Trp Arg Asp Lys Ile Gly Val Met Val Cys Val Gly Ile Met Ala Ala 
        275                 280                 285             


Cys Pro Ser Gly His Ala Ala Ile Leu Ile Ser Gly Asn Ala Lys Leu 
    290                 295                 300                 


Arg Arg Ala Val Met Thr Ile Leu Leu Trp Ala Gln Ser Ser Leu Lys 
305                 310                 315                 320 


Val Arg Ala Asp His Lys Ala Asp Ser Arg Thr Leu Cys 
                325                 330             


<210>  2
<211>  1143
<212>  DNA
<213>  Homo sapiens

<400>  2
cctttctgca ctgggtggca accaggtctt tagattagcc aactagagaa gagaagtaga       60

atagccaatt agagaagtga catcatgttg actctaactc gcatccgcac tgtgtcctat      120

gaagtcagga gtacatttct gttcatttca gtcctggagt ttgcagtggg gtttctgacc      180

aatgccttcg ttttcttggt gaatttttgg gatgtagtga agaggcaggc actgagcaac      240

agtgattgtg tgctgctgtg tctcagcatc agccggcttt tcctgcatgg actgctgttc      300

ctgagtgcta tccagcttac ccacttccag aagttgagtg aaccactgaa ccacagctac      360

caagccatca tcatgctatg gatgattgca aaccaagcca acctctggct tgctgcctgc      420

ctcagcctgc tttactgctc caagctcatc cgtttctctc acaccttcct gatctgcttg      480

gcaagctggg tctccaggaa gatctcccag atgctcctgg gtattattct ttgctcctgc      540

atctgcactg tcctctgtgt ttggtgcttt tttagcagac ctcacttcac agtcacaact      600

gtgctattca tgaataacaa tacaaggctc aactggcaga ttaaagatct caatttattt      660

tattcctttc tcttctgcta tctgtggtct gtgcctcctt tcctattgtt tctggtttct      720

tctgggatgc tgactgtctc cctgggaagg cacatgagga caatgaaggt ctataccaga      780

aactctcgtg accccagcct ggaggcccac attaaagccc tcaagtctct tgtctccttt      840

ttctgcttct ttgtgatatc atcctgtgtt gccttcatct ctgtgcccct actgattctg      900

tggcgcgaca aaataggggt gatggtttgt gttgggataa tggcagcttg tccctctggg      960

catgcagcca tcctgatctc aggcaatgcc aagttgagga gagctgtgat gaccattctg     1020

ctctgggctc agagcagcct gaaggtaaga gccgaccaca aggcagattc ccggacactg     1080

tgctgagaat ggacatgaaa tgagctcttc attaatacgc ctgtgagtct tcataaatat     1140

gcc                                                                   1143


<210>  3
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA directed against human T2R38

<400>  3
ccagaugcuc cuggguauua uucuu                                             25


<210>  4
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA directed against human T2R38

<400>  4
aagaauaaua cccaggagca ucugg                                             25


<210>  5
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA directed against human T2R38

<400>  5
ggcacaugag gacaaugaag gucua                                             25


<210>  6
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA directed against human T2R38

<400>  6
uagaccuuca uuguccucau gugcc                                             25


<210>  7
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA directed against human T2R38

<400>  7
ccuacugauu cuguggcgcg acaaa                                             25


<210>  8
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA directed against human T2R38

<400>  8
uuugucgcgc cacagaauca guagg                                             25


