                         SEQUENCE LISTING

<110>  Laboratorios del Dr. Esteve, S.A.
       Fundaci Privada Institut de Recerca de la SIDA-Caixa
       Instituci Catalana de Recerca i Estudis Avanats
 
<120>   IMMUNOGENS FOR HIV VACCINATION

<130>  P7568PC00

<150>  EP12382031.8
<151>  2012-01-27

<160>  95    

<170>  PatentIn version 3.5

<210>  1
<211>  78
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP HIV clade B consensus sequence

<400>  1

Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Lys Leu Lys 
1               5                   10                  15      


His Ile Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Val Asn Pro 
            20                  25                  30          


Gly Leu Leu Glu Thr Ser Glu Gly Cys Arg Gln Ile Leu Gly Gln Leu 
        35                  40                  45              


Gln Pro Ser Leu Gln Thr Gly Ser Glu Glu Leu Lys Ser Leu Tyr Asn 
    50                  55                  60                  


Thr Val Ala Thr Leu Tyr Cys Val His Gln Lys Ile Glu Val 
65                  70                  75              


<210>  2
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP HIV clade B consensus sequence

<400>  2

Lys Ala Phe Ser Pro Glu Val Ile Pro Met Phe Ser Ala Leu 
1               5                   10                  


<210>  3
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP HIV clade B consensus sequence

<400>  3

Gly His Gln Ala Ala Met Gln Met Leu Lys Glu 
1               5                   10      


<210>  4
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP HIV clade B consensus sequence

<400>  4

Ile Ala Pro Gly Gln Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly 
1               5                   10                  15      


Thr Thr Ser Thr Leu Gln Glu Gln Ile Gly Trp Met Thr Asn Asn Pro 
            20                  25                  30          


Pro Ile Pro Val Gly Glu Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu 
        35                  40                  45              


Asn Lys Ile Val Arg Met Tyr Ser Pro Thr Ser Ile 
    50                  55                  60  


<210>  5
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP HIV clade B consensus sequence

<400>  5

Tyr Val Asp Arg Phe Tyr Lys Thr Leu Arg Ala Glu Gln Ala 
1               5                   10                  


<210>  6
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP HIV clade B consensus sequence

<400>  6

Ala Cys Gln Gly Val Gly Gly Pro Gly His Lys Ala Arg Val Leu 
1               5                   10                  15  


<210>  7
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP HIV clade B consensus sequence

<400>  7

Cys Thr Glu Arg Gln Ala Asn Phe Leu Gly Lys Ile Trp Pro Ser His 
1               5                   10                  15      


Lys Gly Arg Pro Gly Asn Phe Leu Gln Ser Arg 
            20                  25          


<210>  8
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP HIV clade B consensus sequence

<400>  8

Lys Met Ile Gly Gly Ile Gly Gly Phe Ile Lys Val Arg Gln Tyr Asp 
1               5                   10                  15      


Gln Ile Leu Ile Glu Ile Cys Gly His Lys Ala Ile Gly Thr Val Leu 
            20                  25                  30          


Val Gly Pro Thr Pro Val Asn Ile Ile Gly Arg Asn Leu Leu Thr Gln 
        35                  40                  45              


Ile Gly Cys Thr Leu Asn Phe 
    50                  55  


<210>  9
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP HIV clade B consensus sequence

<400>  9

Leu Val Glu Ile Cys Thr Glu Leu Glu Lys Glu Gly Lys Ile Ser Lys 
1               5                   10                  15      


Ile 
    


<210>  10
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP HIV clade B consensus sequence

<400>  10

Leu Arg Trp Gly Phe Thr Thr Pro Asp Lys Lys His Gln Lys Glu Pro 
1               5                   10                  15      


Pro Phe Leu Trp Met Gly Tyr Glu Leu His Pro Asp Lys Trp Thr Val 
            20                  25                  30          


Gln Pro Ile Val Leu Pro Glu Lys Asp Ser Trp Thr Val Asn Asp Ile 
        35                  40                  45              


Gln Lys Leu Val Gly Lys Leu 
    50                  55  


<210>  11
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP HIV clade B consensus sequence

<400>  11

Ile Leu Lys Glu Pro Val His Gly Val Tyr Tyr Asp Pro Ser Lys Asp 
1               5                   10                  15      


Leu Ile Ala Glu Ile Gln Lys Gln Gly Gln Gly Gln Trp Thr Tyr Gln 
            20                  25                  30          


Ile Tyr 
        


<210>  12
<211>  34
<212>  PRT
<213>  Artificial sequence

<220>
<223>  OLP HIV clade B consensus sequence

<400>  12

Thr Lys Glu Leu Gln Lys Gln Ile Thr Lys Ile Gln Asn Phe Arg Val 
1               5                   10                  15      


Tyr Tyr Arg Asp Ser Arg Asp Pro Leu Trp Lys Gly Pro Ala Lys Leu 
            20                  25                  30          


Leu Trp 
        


<210>  13
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP HIV clade B consensus sequence

<400>  13

Lys Ile Ile Arg Asp Tyr Gly Lys Gln Met Ala Gly Asp Asp Cys Val 
1               5                   10                  15      


Ala 
    


<210>  14
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP HIV clade B consensus sequence

<400>  14

Val Lys His His Met Tyr Ile Ser Lys Lys Ala Lys Gly Trp Phe Tyr 
1               5                   10                  15      


Arg His His Tyr Glu Ser Thr His Pro Arg 
            20                  25      


<210>  15
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP HIV clade B consensus sequence

<400>  15

Val Thr Lys Leu Thr Glu Asp Arg Trp Asn Lys Pro Gln Lys Thr Lys 
1               5                   10                  15      


Gly His Arg 
            


<210>  16
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP HIV clade B consensus sequence

<400>  16

Ala Trp Leu Glu Ala Gln Glu Glu Glu Glu Val Gly Phe 
1               5                   10              


<210>  17
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP HIV clade B consensus sequence

<400>  17

Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Lys Leu Lys 
1               5                   10                  15      


His Ile Val Trp Ala Ser Arg 
            20              


<210>  18
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP HIV clade B consensus sequence

<400>  18

Lys Leu Lys His Ile Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala 
1               5                   10                  15      


Val Asn Pro Gly Leu Leu 
            20          


<210>  19
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP HIV clade B consensus sequence

<400>  19

Glu Arg Phe Ala Val Asn Pro Gly Leu Leu Glu Thr Ser Glu Gly Cys 
1               5                   10                  15      


Arg Gln Ile Leu Gly Gln Leu 
            20              


<210>  20
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP HIV clade B consensus sequence

<400>  20

Glu Gly Cys Arg Gln Ile Leu Gly Gln Leu Gln Pro Ser Leu Gln Thr 
1               5                   10                  15      


Gly Ser Glu Glu Leu Lys Ser Leu 
            20                  


<210>  21
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP HIV clade B consensus sequence

<400>  21

Gln Thr Gly Ser Glu Glu Leu Lys Ser Leu Tyr Asn Thr Val Ala Thr 
1               5                   10                  15      


Leu Tyr Cys Val His Gln Arg Ile Glu Val 
            20                  25      


<210>  22
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP HIV clade B consensus sequence

<400>  22

Lys Ala Phe Ser Pro Glu Val Ile Pro Met Phe Ser Ala Leu 
1               5                   10                  


<210>  23
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP HIV clade B consensus sequence

<400>  23

Gly His Gln Ala Ala Met Gln Met Leu Lys Glu 
1               5                   10      


<210>  24
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP HIV clade B consensus sequence

<400>  24

Ile Ala Pro Gly Gln Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly 
1               5                   10                  15      


Thr Thr Ser Thr Leu 
            20      


<210>  25
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP HIV clade B consensus sequence

<400>  25

Ser Asp Ile Ala Gly Thr Thr Ser Thr Leu Gln Glu Gln Ile Gly Trp 
1               5                   10                  15      


Met Thr Asn Asn Pro Pro Ile 
            20              


<210>  26
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP HIV clade B consensus sequence

<400>  26

Ile Gly Trp Met Thr Asn Asn Pro Pro Ile Pro Val Gly Glu Ile Tyr 
1               5                   10                  15      


Lys Arg Trp Ile Ile Leu Gly Leu 
            20                  


<210>  27
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP HIV clade B consensus sequence

<400>  27

Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys Ile Val Arg Met 
1               5                   10                  15      


Tyr Ser Pro Thr Ser Ile 
            20          


<210>  28
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP HIV clade B consensus sequence

<400>  28

Tyr Val Asp Arg Phe Tyr Lys Thr Leu Arg Ala Glu Gln Ala 
1               5                   10                  


<210>  29
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP HIV clade B consensus sequence

<400>  29

Ala Cys Gln Gly Val Gly Gly Pro Gly His Lys Ala Arg Val Leu 
1               5                   10                  15  


<210>  30
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP HIV clade B consensus sequence

<400>  30

Cys Thr Glu Arg Gln Ala Asn Phe Leu Gly Lys Ile Trp Pro Ser His 
1               5                   10                  15      


Lys Gly Arg Pro Gly Asn Phe Leu Gln Ser Arg 
            20                  25          


<210>  31
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP HIV clade B consensus sequence

<400>  31

Lys Met Ile Gly Gly Ile Gly Gly Phe Ile Lys Val Arg Gln Tyr Asp 
1               5                   10                  15      


Gln Ile Leu Ile Glu Ile Cys Gly His Lys 
            20                  25      


<210>  32
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP HIV clade B consensus sequence

<400>  32

Gln Ile Leu Ile Glu Ile Cys Gly His Lys Ala Ile Gly Thr Val Leu 
1               5                   10                  15      


Val Gly Pro Thr Pro Val Asn Ile 
            20                  


<210>  33
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP HIV clade B consensus sequence

<400>  33

Val Leu Val Gly Pro Thr Pro Val Asn Ile Ile Gly Arg Asn Leu Leu 
1               5                   10                  15      


Thr Gln Ile Gly Cys Thr Leu Asn Phe 
            20                  25  


<210>  34
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP HIV clade B consensus sequence

<400>  34

Leu Val Glu Ile Cys Thr Glu Met Glu Lys Glu Gly Lys Ile Ser Lys 
1               5                   10                  15      


Ile 
    


<210>  35
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP HIV clade B consensus sequence

<400>  35

Leu Arg Trp Gly Phe Thr Thr Pro Asp Lys Lys His Gln Lys Glu Pro 
1               5                   10                  15      


Pro Phe Leu Trp Met Gly Tyr Glu Leu 
            20                  25  


<210>  36
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP HIV clade B consensus sequence

<400>  36

Pro Pro Phe Leu Trp Met Gly Tyr Glu Leu His Pro Asp Lys Trp Thr 
1               5                   10                  15      


Val Gln Pro Ile Val Leu Pro Glu Lys 
            20                  25  


<210>  37
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP HIV clade B consensus sequence

<400>  37

Thr Val Gln Pro Ile Val Leu Pro Glu Lys Asp Ser Trp Thr Val Asn 
1               5                   10                  15      


Asp Ile Gln Lys Leu Val Gly Lys Leu 
            20                  25  


<210>  38
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP HIV clade B consensus sequence

<400>  38

Ile Leu Lys Glu Pro Val His Gly Val Tyr Tyr Asp Pro Ser Lys Asp 
1               5                   10                  15      


Leu Ile Ala Glu Ile Gln Lys 
            20              


<210>  39
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP HIV clade B consensus sequence

<400>  39

Ser Lys Asp Leu Ile Ala Glu Ile Gln Lys Gln Gly Gln Gly Gln Trp 
1               5                   10                  15      


Thr Tyr Gln Ile Tyr 
            20      


<210>  40
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP HIV clade B consensus sequence

<400>  40

Thr Lys Glu Leu Gln Lys Gln Ile Thr Lys Ile Gln Asn Phe Arg Val 
1               5                   10                  15      


Tyr Tyr Arg Asp Ser Arg 
            20          


<210>  41
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP HIV clade B consensus sequence

<400>  41

Asn Phe Arg Val Tyr Tyr Arg Asp Ser Arg Asp Pro Leu Trp Lys Gly 
1               5                   10                  15      


Pro Ala Lys Leu Leu Trp 
            20          


<210>  42
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP HIV clade B consensus sequence

<400>  42

Lys Ile Ile Arg Asp Tyr Gly Lys Gln Met Ala Gly Asp Asp Cys Val 
1               5                   10                  15      


Ala 
    


<210>  43
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP HIV clade B consensus sequence

<400>  43

Val Lys His His Met Tyr Ile Ser Lys Lys Ala Lys Gly Trp Phe Tyr 
1               5                   10                  15      


Arg His His Tyr Glu Ser Thr His Pro Arg 
            20                  25      


<210>  44
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP HIV clade B consensus sequence

<400>  44

Val Thr Lys Leu Thr Glu Asp Arg Trp Asn Lys Pro Gln Lys Thr Lys 
1               5                   10                  15      


Gly His Arg 
            


<210>  45
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP HIV clade B consensus sequence

<400>  45

Ala Trp Leu Glu Ala Gln Glu Glu Glu Glu Val Gly Phe 
1               5                   10              


<210>  46
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser 
    


<210>  47
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human GM-CSF signal peptide + V

<400>  47

Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Val 
        


<210>  48
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flag-tag

<400>  48

Asp Tyr Lys Asp Asp Asp Asp Lys Leu 
1               5                   


<210>  49
<211>  556
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HIV immunogen comprising OLPs

<400>  49

Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Val Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Lys 
            20                  25                  30          


Leu Lys His Ile Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Val 
        35                  40                  45              


Asn Pro Gly Leu Leu Glu Thr Ser Glu Gly Cys Arg Gln Ile Leu Gly 
    50                  55                  60                  


Gln Leu Gln Pro Ser Leu Gln Thr Gly Ser Glu Glu Leu Lys Ser Leu 
65                  70                  75                  80  


Tyr Asn Thr Val Ala Thr Leu Tyr Cys Val His Gln Lys Ile Glu Val 
                85                  90                  95      


Ala Ala Ala Lys Ala Phe Ser Pro Glu Val Ile Pro Met Phe Ser Ala 
            100                 105                 110         


Leu Ala Ala Ala Gly His Gln Ala Ala Met Gln Met Leu Lys Glu Ala 
        115                 120                 125             


Ala Ala Ile Ala Pro Gly Gln Met Arg Glu Pro Arg Gly Ser Asp Ile 
    130                 135                 140                 


Ala Gly Thr Thr Ser Thr Leu Gln Glu Gln Ile Gly Trp Met Thr Asn 
145                 150                 155                 160 


Asn Pro Pro Ile Pro Val Gly Glu Ile Tyr Lys Arg Trp Ile Ile Leu 
                165                 170                 175     


Gly Leu Asn Lys Ile Val Arg Met Tyr Ser Pro Thr Ser Ile Ala Ala 
            180                 185                 190         


Ala Tyr Val Asp Arg Phe Tyr Lys Thr Leu Arg Ala Glu Gln Ala Ala 
        195                 200                 205             


Ala Cys Gln Gly Val Gly Gly Pro Gly His Lys Ala Arg Val Leu Ala 
    210                 215                 220                 


Ala Ala Cys Thr Glu Arg Gln Ala Asn Phe Leu Gly Lys Ile Trp Pro 
225                 230                 235                 240 


Ser His Lys Gly Arg Pro Gly Asn Phe Leu Gln Ser Arg Ala Ala Ala 
                245                 250                 255     


Lys Met Ile Gly Gly Ile Gly Gly Phe Ile Lys Val Arg Gln Tyr Asp 
            260                 265                 270         


Gln Ile Leu Ile Glu Ile Cys Gly His Lys Ala Ile Gly Thr Val Leu 
        275                 280                 285             


Val Gly Pro Thr Pro Val Asn Ile Ile Gly Arg Asn Leu Leu Thr Gln 
    290                 295                 300                 


Ile Gly Cys Thr Leu Asn Phe Ala Ala Leu Val Glu Ile Cys Thr Glu 
305                 310                 315                 320 


Met Glu Lys Glu Gly Lys Ile Ser Lys Ile Ala Ala Ala Leu Arg Trp 
                325                 330                 335     


Gly Phe Thr Thr Pro Asp Lys Lys His Gln Lys Glu Pro Pro Phe Leu 
            340                 345                 350         


Trp Met Gly Tyr Glu Leu His Pro Asp Lys Trp Thr Val Gln Pro Ile 
        355                 360                 365             


Val Leu Pro Glu Lys Asp Ser Trp Thr Val Asn Asp Ile Gln Lys Leu 
    370                 375                 380                 


Val Gly Lys Leu Ala Ala Ala Ile Leu Lys Glu Pro Val His Gly Val 
385                 390                 395                 400 


Tyr Tyr Asp Pro Ser Lys Asp Leu Ile Ala Glu Ile Gln Lys Gln Gly 
                405                 410                 415     


Gln Gly Gln Trp Thr Tyr Gln Ile Tyr Ala Ala Ala Thr Lys Glu Leu 
            420                 425                 430         


Gln Lys Gln Ile Thr Lys Ile Gln Asn Phe Arg Val Tyr Tyr Arg Asp 
        435                 440                 445             


Ser Arg Asp Pro Leu Trp Lys Gly Pro Ala Lys Leu Leu Trp Ala Ala 
    450                 455                 460                 


Ala Lys Ile Ile Arg Asp Tyr Gly Lys Gln Met Ala Gly Asp Asp Cys 
465                 470                 475                 480 


Val Ala Ala Ala Val Lys His His Met Tyr Ile Ser Lys Lys Ala Lys 
                485                 490                 495     


Gly Trp Phe Tyr Arg His His Tyr Glu Ser Thr His Pro Arg Ala Ala 
            500                 505                 510         


Ala Val Thr Lys Leu Thr Glu Asp Arg Trp Asn Lys Pro Gln Lys Thr 
        515                 520                 525             


Lys Gly His Arg Ala Ala Ala Trp Leu Glu Ala Gln Glu Glu Glu Glu 
    530                 535                 540                 


Val Gly Phe Asp Tyr Lys Asp Asp Asp Asp Lys Leu 
545                 550                 555     


<210>  50
<211>  1674
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide encoding immunogen comprising HIV OLPs

<400>  50
atgtggctcc agagcctgct actcctgggg acggtggcct gcagcatctc ggtcgagaag       60

atccggctgc ggccaggcgg aaagaagaag tacaagctga agcacatcgt ctgggcctcg      120

agggagctgg agcggttcgc ggtgaacccg ggacttctgg agacgtcgga ggggtgcagg      180

cagatcctcg gccagctgca gccctctctg caaacggggt ctgaggagct gaagagcctg      240

tacaacacgg tggcgaccct ctactgcgtc caccagaaga tcgaggtggc agcggccaag      300

gcgttctcgc cggaggtcat ccccatgttc tcggcgctgg cagctgccgg acaccaggcc      360

gcgatgcaga tgctgaagga ggccgctgcg atcgcaccgg gccagatgag ggagccacgc      420

ggttccgaca tcgcgggaac cacctcgacg ctccaggagc agatcggatg gatgacgaac      480

aacccgccaa tcccggtcgg ggagatctac aagcggtgga tcatcctcgg gctgaacaag      540

atcgtccgga tgtacagccc gacgtcgatc gctgcggcat acgttgaccg gttctacaag      600

accctgaggg ccgagcaggc agcggcctgc cagggggtcg gtggaccagg gcacaaggcc      660

cgagtgctcg cggccgcatg cacggagcgg caggcgaact tcctggggaa gatctggccg      720

tcgcacaagg gccgaccggg aaacttcctc cagtctcgcg cagcggctaa gatgatcgga      780

ggcatcggag gcttcatcaa agtccgtcag tacgaccaga tcctcatcga gatctgcggg      840

cacaaggcga tcggaaccgt gctcgtcggc ccaacgcccg tgaacatcat cggccgcaac      900

ctgttaacgc agatcggctg caccctcaac ttcgccgcac tagtggagat ctgcacggag      960

atggagaagg agggcaagat atcgaagatc gcggcagctc tgaggtgggg cttcaccacg     1020

ccggacaaga agcaccagaa ggagccgcca ttcctgtgga tgggatacga gctgcacccg     1080

gacaagtgga ccgtgcagcc catcgtcctg ccggagaagg actcgtggac ggtgaacgac     1140

atccagaagc tcgtggggaa gctggcggca gccatcctca aggagcccgt ccacggggtg     1200

tactacgacc cctctaagga cctgatcgcg gagatccaga agcaggggca gggtcagtgg     1260

acctaccaga tctacgcagc agcaaccaag gagctgcaga agcagatcac gaagatccag     1320

aacttccgcg tatactaccg cgactcgcgg gaccccctgt ggaagggccc tgcgaagctt     1380

ctctgggcag ccgcgaagat catccgggac tacggcaagc agatggcggg cgacgactgc     1440

gtggccgcag cggtgaagca ccatatgtac atctcgaaga aggcgaaggg ctggttctac     1500

agacaccact acgagtccac ccaccccagg gcagctgcgg tgacgaagct gacggaggac     1560

cggtggaaca agccccagaa gacgaagggt caccgggcgg ctgcatggct ggaggctcag     1620

gaggaggagg aggtgggctt cgattacaag gacgatgacg acaagctgtg ataa           1674


<210>  51
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  198HPlus primer

<400>  51
gtcaccgggc ggctgcatgg ctggaggctc aggaggagga ggaggtgggc ttctgataag       60


<210>  52
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  298HMinus primer

<400>  52
aattcttatc agaagcccac ctcctcctcc tcctgagcct ccagccatgc agccgcccg        59


<210>  53
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP clade B consensus sequence

<400>  53

Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Lys Leu Lys 
1               5                   10                  15      


His Ile 
        


<210>  54
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP clade B consensus sequence

<400>  54

Ala Ser Arg Glu Leu Glu Arg Phe Ala Val Asn Pro Gly Leu Leu 
1               5                   10                  15  


<210>  55
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP clade B consensus sequence

<400>  55

Glu Arg Phe Ala Val Asn Pro Gly Leu Leu Glu Thr Ser Glu Gly Cys 
1               5                   10                  15      


Arg 
    


<210>  56
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP clade B consensus sequence

<400>  56

Gln Leu Gln Pro Ser Leu Gln Thr Gly Ser Glu Glu Leu Arg Ser Leu 
1               5                   10                  15      


Tyr 
    


<210>  57
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP clade B consensus sequence

<400>  57

Ser Leu Tyr Asn Thr Val Ala Thr Leu Tyr Cys Val His Gln Arg Ile 
1               5                   10                  15      


Glu Val 
        


<210>  58
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP clade B consensus sequence

<400>  58

Ala Phe Ser Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ser Glu Gly 
1               5                   10                  15      


Ala 
    


<210>  59
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP clade B consensus sequence

<400>  59

Ile Ala Pro Gly Gln Met Arg Glu Pro Arg Gly Ser Asp Ile Ala 
1               5                   10                  15  


<210>  60
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP clade B consensus sequence

<400>  60

Ser Thr Leu Gln Glu Gln Ile Gly Trp Met Thr Asn Asn Pro Pro Ile 
1               5                   10                  15      


Pro Val 
        


<210>  61
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP clade B consensus sequence

<400>  61

Ala Cys Gln Gly Val Gly Gly Pro Gly His Lys Ala Arg Val Leu Ala 
1               5                   10                  15      


Glu Ala 
        


<210>  62
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP clade B consensus sequence

<400>  62

Gly Lys Ile Trp Pro Ser His Lys Gly Arg Pro Gly Asn Phe Leu Gln 
1               5                   10                  15      


Ser Arg 
        


<210>  63
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP clade B consensus sequence

<400>  63

Trp Leu Glu Ala Gln Glu Glu Glu Glu Val Gly Phe Pro Val Arg Pro 
1               5                   10                  15      


Gln Val 
        


<210>  64
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP clade B consensus sequence

<400>  64

Glu Val Gly Phe Pro Val Arg Pro Gln Val Pro Leu Arg Pro Met Thr 
1               5                   10                  15      


Tyr Lys 
        


<210>  65
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP clade B consensus sequence

<400>  65

Asn Tyr Thr Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp 
1               5                   10                  15      


Cys Phe 
        


<210>  66
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP clade B consensus sequence

<400>  66

Arg Tyr Pro Leu Thr Phe Gly Trp Cys Phe Lys Leu Val Pro Val 
1               5                   10                  15  


<210>  67
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP clade B consensus sequence

<400>  67

Ser Leu His Gly Met Asp Asp Pro Glu Lys Glu Val Leu Val Trp Lys 
1               5                   10                  15      


Phe 
    


<210>  68
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP clade B consensus sequence

<400>  68

Lys Met Ile Gly Gly Ile Gly Gly Phe Ile Lys Val Arg Gln Tyr Asp 
1               5                   10                  15      


Gln Ile 
        


<210>  69
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP clade B consensus sequence

<400>  69

Phe Ile Lys Val Arg Gln Tyr Asp Gln Ile Leu Ile Glu Ile Cys Gly 
1               5                   10                  15      


His Lys 
        


<210>  70
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP clade B consensus sequence

<400>  70

Gln Ile Leu Ile Glu Ile Cys Gly His Lys Ala Ile Gly Thr Val Leu 
1               5                   10                  15      


Val 
    


<210>  71
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP clade B consensus sequence

<400>  71

Leu Val Gly Pro Thr Pro Val Asn Ile Ile Gly Arg Asn Leu Leu Thr 
1               5                   10                  15      


Gln Ile 
        


<210>  72
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP clade B consensus sequence

<400>  72

Leu Val Glu Ile Cys Thr Glu Met Glu Lys Glu Gly Lys Ile Ser Lys 
1               5                   10                  15      


Ile 
    


<210>  73
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP clade B consensus sequence

<400>  73

Leu Asp Val Gly Asp Ala Tyr Phe Ser Val Pro Leu Asp Lys Asp Phe 
1               5                   10                  15      


Arg Lys 
        


<210>  74
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP clade B consensus sequence

<400>  74

Leu Arg Trp Gly Phe Thr Thr Pro Asp Lys Lys His Gln Lys Glu Pro 
1               5                   10                  15      


Pro Phe 
        


<210>  75
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP clade B consensus sequence

<400>  75

Asp Lys Lys His Gln Lys Glu Pro Pro Phe Leu Trp Met Gly Tyr Glu 
1               5                   10                  15      


Leu His 
        


<210>  76
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP clade B consensus sequence

<400>  76

Glu Ile Gln Lys Gln Gly Gln Gly Gln Trp Thr Tyr Gln Ile Tyr 
1               5                   10                  15  


<210>  77
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP clade B consensus sequence

<400>  77

Pro Pro Leu Val Lys Leu Trp Tyr Gln Leu Glu Lys Glu Pro Ile Val 
1               5                   10                  15      


Gly Ala 
        


<210>  78
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP clade B consensus sequence

<400>  78

Ile His Leu Ala Leu Gln Asp Ser Gly Leu Glu Val Asn Ile Val 
1               5                   10                  15  


<210>  79
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP clade B consensus sequence

<400>  79

Val Tyr Leu Ala Trp Val Pro Ala His Lys Gly Ile Gly Gly Asn Glu 
1               5                   10                  15      


Gln Val 
        


<210>  80
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP clade B consensus sequence

<400>  80

Ser Ala Gly Ile Arg Lys Val Leu Phe Leu Asp Gly Ile Asp Lys Ala 
1               5                   10                  15      


<210>  81
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP clade B consensus sequence

<400>  81

Thr Lys Glu Leu Gln Lys Gln Ile Thr Lys Ile Gln Asn Phe Arg Val 
1               5                   10                  15      


Tyr Tyr 
        


<210>  82
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP clade B consensus sequence

<400>  82

Thr Lys Ile Gln Asn Phe Arg Val Tyr Tyr Arg Asp Ser Arg Asp Pro 
1               5                   10                  15      


Leu Trp 
        


<210>  83
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP clade B consensus sequence

<400>  83

Tyr Tyr Arg Asp Ser Arg Asp Pro Leu Trp Lys Gly Pro Ala Lys Leu 
1               5                   10                  15      


Leu Trp 
        


<210>  84
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP clade B consensus sequence

<400>  84

Lys Ile Ile Arg Asp Tyr Gly Lys Gln Met Ala Gly Asp Asp Cys Val 
1               5                   10                  15      


Ala 
    


<210>  85
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP clade B consensus sequence

<400>  85

Gly Pro Gln Arg Glu Pro Tyr Asn Glu Trp Thr Leu Glu Leu Leu Glu 
1               5                   10                  15      


Glu Leu 
        


<210>  86
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP clade B consensus sequence

<400>  86

Asp Leu Asn Asn Asn Thr Asn Thr Thr Ser Ser Ser Gly Glu Lys Met 
1               5                   10                  15      


Glu Lys 
        


<210>  87
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP clade B consensus sequence

<400>  87

Ile Arg Asp Lys Val Gln Lys Glu Tyr Ala Leu Phe Tyr Lys Leu Asp 
1               5                   10                  15      


Val Val 
        


<210>  88
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP clade B consensus sequence

<400>  88

Tyr Arg Leu Ile Ser Cys Asn Thr Ser Val Ile Thr Gln Ala Cys Pro 
1               5                   10                  15      


Lys Val 
        


<210>  89
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP clade B consensus sequence

<400>  89

Ser Val Ile Thr Gln Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro 
1               5                   10                  15      


Ile His 
        


<210>  90
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP clade B consensus sequence

<400>  90

Thr Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Val 
1               5                   10                  15      


<210>  91
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP clade B consensus sequence

<400>  91

Val Ala Pro Thr Lys Ala Lys Arg Arg Val Val Gln Arg Glu Lys Arg 
1               5                   10                  15      


Ala Val 
        


<210>  92
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP clade B consensus sequence

<400>  92

Val Ile Glu Val Val Gln Arg Ala Cys Arg Ala Ile Leu His Ile Pro 
1               5                   10                  15      


Arg Arg 
        


<210>  93
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP clade B consensus sequence

<400>  93

Val Lys His His Met Tyr Ile Ser Gly Lys Ala Lys Gly Trp Phe Tyr 
1               5                   10                  15      


Arg His 
        


<210>  94
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP clade B consensus sequence

<400>  94

Gly Lys Ala Lys Gly Trp Phe Tyr Arg His His Tyr Glu Ser Thr His 
1               5                   10                  15      


Pro Arg 
        


<210>  95
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OLP clade B consensus sequence

<400>  95

Thr Lys Leu Thr Glu Asp Arg Trp Asn Lys Pro Gln Lys Thr Lys Gly 
1               5                   10                  15      


His Arg 
        


