                         SEQUENCE LISTING

<110>  Arla Foods amba

<120>  Method of producing a galacto-oligosaccharide-containing composition

<130>  P1120PC00

<160>  2     

<170>  PatentIn version 3.1

<210>  1
<211>  5509
<212>  DNA
<213>  Bifidobacterium bifidum

<220>
<221>  CDS
<222>  (212)..(5470)
<223>  

<400>  1
atgcgttgcg ttgcgatttt tccggccctg tatgggggat acaggattgg cgatggcgac     60

acgccgtttt tgttaatggc atttacatga aatacaggta atgagatatc attctcatga    120

tcaccgtgtg gatatcgcat tggtgcgtat acactaacag caacagagcg gcgcggcagg    180

cgctcgtgga ttcaatgaag aaggaacgtt t atg gca gtt cgc aga ctt ggt       232
                                   Met Ala Val Arg Arg Leu Gly          
                                   1               5                    

ggc cgc atc gtg gct ttc gcc gcc aca gtg gcc ttg tca ata ccg tta      280
Gly Arg Ile Val Ala Phe Ala Ala Thr Val Ala Leu Ser Ile Pro Leu         
        10                  15                  20                      

ggg ttg tta aca aat tca gcg tgg gcg gtc gag gac gcc acc cga tcc      328
Gly Leu Leu Thr Asn Ser Ala Trp Ala Val Glu Asp Ala Thr Arg Ser         
    25                  30                  35                          

gac tcc acc acg cag atg agc tcc acg ccg gag gtg gtc tac tcc agc      376
Asp Ser Thr Thr Gln Met Ser Ser Thr Pro Glu Val Val Tyr Ser Ser         
40                  45                  50                  55          

gcc gtg gat tcc aag cag aat cgc acc tcg gat ttc gac gcc aac tgg      424
Ala Val Asp Ser Lys Gln Asn Arg Thr Ser Asp Phe Asp Ala Asn Trp         
                60                  65                  70              

aag ttc atg ctg tcc gat tcc gtg cag gcg cag gat ccg gcg ttc gac      472
Lys Phe Met Leu Ser Asp Ser Val Gln Ala Gln Asp Pro Ala Phe Asp         
            75                  80                  85                  

gat tcg gcc tgg cag cag gtc gac ctg ccg cat gac tac agc atc acg      520
Asp Ser Ala Trp Gln Gln Val Asp Leu Pro His Asp Tyr Ser Ile Thr         
        90                  95                  100                     

cag aag tat tcg cag agc aac gag gcc gaa agc gca tac ctt ccc ggc      568
Gln Lys Tyr Ser Gln Ser Asn Glu Ala Glu Ser Ala Tyr Leu Pro Gly         
    105                 110                 115                         

ggc acc ggc tgg tac cgc aag tcc ttc acc atc gac cgg gac ctc gcc      616
Gly Thr Gly Trp Tyr Arg Lys Ser Phe Thr Ile Asp Arg Asp Leu Ala         
120                 125                 130                 135         

ggc aag cgc atc gcc atc aac ttc gac ggc gtg tac atg aac gcc acc      664
Gly Lys Arg Ile Ala Ile Asn Phe Asp Gly Val Tyr Met Asn Ala Thr         
                140                 145                 150             

gtc tgg ttc aac ggc gtc aag ctc ggc acc cat ccg tac ggc tac tcg      712
Val Trp Phe Asn Gly Val Lys Leu Gly Thr His Pro Tyr Gly Tyr Ser         
            155                 160                 165                 

ccg ttc tcc ttc gac ctg acc ggc aac gcc aag ttc ggt ggg gag aac      760
Pro Phe Ser Phe Asp Leu Thr Gly Asn Ala Lys Phe Gly Gly Glu Asn         
        170                 175                 180                     

acc atc gtc gtc aag gtc gag aac agg ctg ccg tcc agc cgc tgg tac      808
Thr Ile Val Val Lys Val Glu Asn Arg Leu Pro Ser Ser Arg Trp Tyr         
    185                 190                 195                         

tcc ggc tcc ggc atc tac cgc gac gtc acc ctc acc gtc acc gac ggc      856
Ser Gly Ser Gly Ile Tyr Arg Asp Val Thr Leu Thr Val Thr Asp Gly         
200                 205                 210                 215         

gtg cac gtc ggc aat aac ggc gtg gcc atc aag acc ccg agc ctc gcc      904
Val His Val Gly Asn Asn Gly Val Ala Ile Lys Thr Pro Ser Leu Ala         
                220                 225                 230             

acc caa aac ggc ggc gac gtg acg atg aac ctc acc acc aag gtc gcc      952
Thr Gln Asn Gly Gly Asp Val Thr Met Asn Leu Thr Thr Lys Val Ala         
            235                 240                 245                 

aac gac acc gag gcc gcg gcg aac atc acc ctc aag cag acc gtg ttc     1000
Asn Asp Thr Glu Ala Ala Ala Asn Ile Thr Leu Lys Gln Thr Val Phe         
        250                 255                 260                     

ccc aag gga ggc aag acc gac gcc gcc atc ggc acc gtc acc acc gca     1048
Pro Lys Gly Gly Lys Thr Asp Ala Ala Ile Gly Thr Val Thr Thr Ala         
    265                 270                 275                         

tcc aag tcc atc gcg gcc ggt gcc agc gcg gac gtg acc tcc acg atc     1096
Ser Lys Ser Ile Ala Ala Gly Ala Ser Ala Asp Val Thr Ser Thr Ile         
280                 285                 290                 295         

acc gcc gct tcg ccc aag ctg tgg agc atc aag aac ccg aac ctg tac     1144
Thr Ala Ala Ser Pro Lys Leu Trp Ser Ile Lys Asn Pro Asn Leu Tyr         
                300                 305                 310             

acc gtg cgc acc gaa gtg ctc aac ggc ggc aag gtg ctc gac act tac     1192
Thr Val Arg Thr Glu Val Leu Asn Gly Gly Lys Val Leu Asp Thr Tyr         
            315                 320                 325                 

gac acc gaa tat ggc ttc cgc tgg acc ggc ttc gat gcg acc agc ggt     1240
Asp Thr Glu Tyr Gly Phe Arg Trp Thr Gly Phe Asp Ala Thr Ser Gly         
        330                 335                 340                     

ttc tcg ctc aac ggc gag aaa gtc aag ctc aag ggc gtc tca atg cat     1288
Phe Ser Leu Asn Gly Glu Lys Val Lys Leu Lys Gly Val Ser Met His         
    345                 350                 355                         

cat gac cag gga tcg ctc ggc gcg gtc gcc aac cgc cgc gcc atc gag     1336
His Asp Gln Gly Ser Leu Gly Ala Val Ala Asn Arg Arg Ala Ile Glu         
360                 365                 370                 375         

cgc cag gtc gag att ctc cag aag atg ggc gtc aac tcg atc cgc acc     1384
Arg Gln Val Glu Ile Leu Gln Lys Met Gly Val Asn Ser Ile Arg Thr         
                380                 385                 390             

acg cac aac ccc gca gcc aag gcg ctg att gac gtc tgc aac gag aag     1432
Thr His Asn Pro Ala Ala Lys Ala Leu Ile Asp Val Cys Asn Glu Lys         
            395                 400                 405                 

ggc gtc ctc gtg gtc gaa gag gtc ttc gac atg tgg aac cgg tcg aag     1480
Gly Val Leu Val Val Glu Glu Val Phe Asp Met Trp Asn Arg Ser Lys         
        410                 415                 420                     

aac ggc aac acc gag gat tac ggc aag tgg ttc ggc cag gcc atc gcc     1528
Asn Gly Asn Thr Glu Asp Tyr Gly Lys Trp Phe Gly Gln Ala Ile Ala         
    425                 430                 435                         

ggt gac aac gcc gtc ctg ggt ggc gac aag gac gag acc tgg gcc aag     1576
Gly Asp Asn Ala Val Leu Gly Gly Asp Lys Asp Glu Thr Trp Ala Lys         
440                 445                 450                 455         

ttc gac ctg acc agc acc atc aac cgt gac agg aac gcc ccg tcc gtc     1624
Phe Asp Leu Thr Ser Thr Ile Asn Arg Asp Arg Asn Ala Pro Ser Val         
                460                 465                 470             

atc atg tgg tcg ctc ggc aac gag atg atg gaa ggc atc agc ggc agc     1672
Ile Met Trp Ser Leu Gly Asn Glu Met Met Glu Gly Ile Ser Gly Ser         
            475                 480                 485                 

gtc tcg ggc ttc ccg gct acc tcc gcc aag ctg gtc gca tgg acg aag     1720
Val Ser Gly Phe Pro Ala Thr Ser Ala Lys Leu Val Ala Trp Thr Lys         
        490                 495                 500                     

gcc gcg gac agc acc cgc ccg atg acc tac ggc gac aac aag atc aag     1768
Ala Ala Asp Ser Thr Arg Pro Met Thr Tyr Gly Asp Asn Lys Ile Lys         
    505                 510                 515                         

gcc aac tgg aac gag tcg aac acc atg ggc gac aac ctg acc gcc aac     1816
Ala Asn Trp Asn Glu Ser Asn Thr Met Gly Asp Asn Leu Thr Ala Asn         
520                 525                 530                 535         

ggc ggc gtg gtc ggc acc aac tac tcc gac ggc gcg aac tac gac aag     1864
Gly Gly Val Val Gly Thr Asn Tyr Ser Asp Gly Ala Asn Tyr Asp Lys         
                540                 545                 550             

atc cgc acg acc cac ccc tca tgg gcc atc tat ggt tcc gag acg gcg     1912
Ile Arg Thr Thr His Pro Ser Trp Ala Ile Tyr Gly Ser Glu Thr Ala         
            555                 560                 565                 

tcc gcc atc aac agc cga ggc atc tac aac cgc acc acc ggc ggc gcc     1960
Ser Ala Ile Asn Ser Arg Gly Ile Tyr Asn Arg Thr Thr Gly Gly Ala         
        570                 575                 580                     

cag tca agc gac aag cag ctg acc agc tat gac aat tcc gca gtc ggc     2008
Gln Ser Ser Asp Lys Gln Leu Thr Ser Tyr Asp Asn Ser Ala Val Gly         
    585                 590                 595                         

tgg ggc gcc gtc gcc agc tcc gcc tgg tac gac gtg gtc cag cgc gat     2056
Trp Gly Ala Val Ala Ser Ser Ala Trp Tyr Asp Val Val Gln Arg Asp         
600                 605                 610                 615         

ttc gtc gcc ggc aca tac gtg tgg acc ggc ttc gac tac ctc ggc gaa     2104
Phe Val Ala Gly Thr Tyr Val Trp Thr Gly Phe Asp Tyr Leu Gly Glu         
                620                 625                 630             

ccc acc ccg tgg aac ggc acc ggc tcc ggc gcc gtg ggc tcc ttg gcc     2152
Pro Thr Pro Trp Asn Gly Thr Gly Ser Gly Ala Val Gly Ser Leu Ala         
            635                 640                 645                 

gtc gcc gaa gaa ctc gta ctt cgg cat cgt cga cac cgc agg ctt ccc     2200
Val Ala Glu Glu Leu Val Leu Arg His Arg Arg His Arg Arg Leu Pro         
        650                 655                 660                     

gaa gac acc tat tac ttc tat cag agc cag tgg aac gac gac gtg cac     2248
Glu Asp Thr Tyr Tyr Phe Tyr Gln Ser Gln Trp Asn Asp Asp Val His         
    665                 670                 675                         

acg ctg cac atc ctc ccc gca tgg aac gag aac gtc gtc gcc aag ggc     2296
Thr Leu His Ile Leu Pro Ala Trp Asn Glu Asn Val Val Ala Lys Gly         
680                 685                 690                 695         

tcc ggc aac aac gtg ccg gtc gtc gtc tac acc gac gcg gcc aag gtc     2344
Ser Gly Asn Asn Val Pro Val Val Val Tyr Thr Asp Ala Ala Lys Val         
                700                 705                 710             

aag ctg tac ttc aca ccg aag ggc agt acc gaa aag cga ctg atc gga     2392
Lys Leu Tyr Phe Thr Pro Lys Gly Ser Thr Glu Lys Arg Leu Ile Gly         
            715                 720                 725                 

gag aag tcc ttc acc aag aag acc acc gcg gcc gga tac acc tat cag     2440
Glu Lys Ser Phe Thr Lys Lys Thr Thr Ala Ala Gly Tyr Thr Tyr Gln         
        730                 735                 740                     

gtc tac gag ggc tcc gac aag gac tcc acc gcc cac aag aac atg tac     2488
Val Tyr Glu Gly Ser Asp Lys Asp Ser Thr Ala His Lys Asn Met Tyr         
    745                 750                 755                         

ctg acc tgg aac gtg ccg tgg gcc gag ggc acc atc tcc gcc gaa gca     2536
Leu Thr Trp Asn Val Pro Trp Ala Glu Gly Thr Ile Ser Ala Glu Ala         
760                 765                 770                 775         

tac gac gag aac aac agg ctg atc ccc gag ggg tcc acc gag ggc aac     2584
Tyr Asp Glu Asn Asn Arg Leu Ile Pro Glu Gly Ser Thr Glu Gly Asn         
                780                 785                 790             

gcg tcg gtg acc acc acc ggc aag gcc gcg aag ctt aaa gcc gat gcc     2632
Ala Ser Val Thr Thr Thr Gly Lys Ala Ala Lys Leu Lys Ala Asp Ala         
            795                 800                 805                 

gac cgc aag acg atc acc gcg gac ggc aag gac ctg tcg tac atc gag     2680
Asp Arg Lys Thr Ile Thr Ala Asp Gly Lys Asp Leu Ser Tyr Ile Glu         
        810                 815                 820                     

gtc gac gtg acc gac gcc aac ggc cat atc gtc ccc gat gcc gcc aac     2728
Val Asp Val Thr Asp Ala Asn Gly His Ile Val Pro Asp Ala Ala Asn         
    825                 830                 835                         

cgc gtc acc ttc gac gtc aag ggc gcc ggc aaa ctg gtc ggc gtc gac     2776
Arg Val Thr Phe Asp Val Lys Gly Ala Gly Lys Leu Val Gly Val Asp         
840                 845                 850                 855         

aac ggc agc tcg ccg gat cac gac tcc tat cag gcc gac aac cgc aag     2824
Asn Gly Ser Ser Pro Asp His Asp Ser Tyr Gln Ala Asp Asn Arg Lys         
                860                 865                 870             

gcg ttc agc ggc aag gtg ctc gcc atc gtc cag tcc acc aag gag gcg     2872
Ala Phe Ser Gly Lys Val Leu Ala Ile Val Gln Ser Thr Lys Glu Ala         
            875                 880                 885                 

ggc gag atc acc gtc acc gcc aag gcc gac ggt ctg caa tca tcc aca     2920
Gly Glu Ile Thr Val Thr Ala Lys Ala Asp Gly Leu Gln Ser Ser Thr         
        890                 895                 900                     

gtg aag atc gcc acc acc gcc gtc ccc ggc acc agc acc gag aag acg     2968
Val Lys Ile Ala Thr Thr Ala Val Pro Gly Thr Ser Thr Glu Lys Thr         
    905                 910                 915                         

gtc cgc agc ttc tac tac tcg cgc aac tac tac gtc aag acc ggc aac     3016
Val Arg Ser Phe Tyr Tyr Ser Arg Asn Tyr Tyr Val Lys Thr Gly Asn         
920                 925                 930                 935         

aag ccg att ctg ccg agt gat gtc gag gtg cgc tac tcc gac ggc acg     3064
Lys Pro Ile Leu Pro Ser Asp Val Glu Val Arg Tyr Ser Asp Gly Thr         
                940                 945                 950             

tcg gac cgt cag aac gtc aca tgg gac gca gtc agc gac gac cag atc     3112
Ser Asp Arg Gln Asn Val Thr Trp Asp Ala Val Ser Asp Asp Gln Ile         
            955                 960                 965                 

gcc aag gcc ggt tcg ttc agc gtg gcc ggc acg gtc gcc ggg cag aag     3160
Ala Lys Ala Gly Ser Phe Ser Val Ala Gly Thr Val Ala Gly Gln Lys         
        970                 975                 980                     

atc tcc gtg cgc gtg acg atg atc gac gag atc ggt gcg ctg ctc aac     3208
Ile Ser Val Arg Val Thr Met Ile Asp Glu Ile Gly Ala Leu Leu Asn         
    985                 990                 995                         

tat  tcg gcc agc aca ccg  gtc ggc acg ccc gcc  gtg ctg cct ggc      3253
Tyr  Ser Ala Ser Thr Pro  Val Gly Thr Pro Ala  Val Leu Pro Gly          
1000                 1005                 1010                          

tcg  cgt ccg gcc gtg ctg  ccc gac ggc acc gtg  acc agc gcg aac      3298
Ser  Arg Pro Ala Val Leu  Pro Asp Gly Thr Val  Thr Ser Ala Asn          
1015                 1020                 1025                          

ttc  gcc gtc cac tgg acc  aag ccc gcc gac acc  gtg tac aac acg      3343
Phe  Ala Val His Trp Thr  Lys Pro Ala Asp Thr  Val Tyr Asn Thr          
1030                 1035                 1040                          

gcc  ggc acc gtc aag gtc  ccc ggc acc gcc acc  gtc ttc ggc aag      3388
Ala  Gly Thr Val Lys Val  Pro Gly Thr Ala Thr  Val Phe Gly Lys          
1045                 1050                 1055                          

gag  ttc aag gtc acc gcg  acg att cgc gtg cag  cgg tcg cag gtc      3433
Glu  Phe Lys Val Thr Ala  Thr Ile Arg Val Gln  Arg Ser Gln Val          
1060                 1065                 1070                          

acc  atc ggc agc agc gtc  tcc ggc aat gcg ctg  cgc ctg act cag      3478
Thr  Ile Gly Ser Ser Val  Ser Gly Asn Ala Leu  Arg Leu Thr Gln          
1075                 1080                 1085                          

aac  atc ccc gcc gac aag  cag tcc gac acg ctg  gac gcc atc aag      3523
Asn  Ile Pro Ala Asp Lys  Gln Ser Asp Thr Leu  Asp Ala Ile Lys          
1090                 1095                 1100                          

gac  ggc tcc acg acc gtc  gac gcc aat acc ggc  ggc ggc gcg aac      3568
Asp  Gly Ser Thr Thr Val  Asp Ala Asn Thr Gly  Gly Gly Ala Asn          
1105                 1110                 1115                          

ccg  tca gca tgg acc aac  tgg gcg tac tcg aag  gcc ggc cac aac      3613
Pro  Ser Ala Trp Thr Asn  Trp Ala Tyr Ser Lys  Ala Gly His Asn          
1120                 1125                 1130                          

acc  gcc gag atc acc ttc  gag tac gcg acc gag  cag cag ctc ggc      3658
Thr  Ala Glu Ile Thr Phe  Glu Tyr Ala Thr Glu  Gln Gln Leu Gly          
1135                 1140                 1145                          

cag  att gtc atg tac ttc  ttc cgc gac agc aac  gcg gtg agg ttc      3703
Gln  Ile Val Met Tyr Phe  Phe Arg Asp Ser Asn  Ala Val Arg Phe          
1150                 1155                 1160                          

ccc  gac gcc ggc aag acg  aag atc cag atc tcc  gcg gac ggc aag      3748
Pro  Asp Ala Gly Lys Thr  Lys Ile Gln Ile Ser  Ala Asp Gly Lys          
1165                 1170                 1175                          

aac  tgg acg gat ctc gct  gcc acg gag acc atc  gcg gcc cag gag      3793
Asn  Trp Thr Asp Leu Ala  Ala Thr Glu Thr Ile  Ala Ala Gln Glu          
1180                 1185                 1190                          

tcg  tcc gac cga gtc aag  ccg tac acc tat gac  ttc gct ccg gtg      3838
Ser  Ser Asp Arg Val Lys  Pro Tyr Thr Tyr Asp  Phe Ala Pro Val          
1195                 1200                 1205                          

gga  gcc acg ttc gtc aag  gtc acg gtc acc aac  gcc gac acc aca      3883
Gly  Ala Thr Phe Val Lys  Val Thr Val Thr Asn  Ala Asp Thr Thr          
1210                 1215                 1220                          

acc  ccc agc ggc gtg gtc  tgc gcc ggc ctg acc  gag atc gag ctg      3928
Thr  Pro Ser Gly Val Val  Cys Ala Gly Leu Thr  Glu Ile Glu Leu          
1225                 1230                 1235                          

aag  acc gcg acc agc aag  ttc gtc acg aac acg  tcc gcc gcg ctc      3973
Lys  Thr Ala Thr Ser Lys  Phe Val Thr Asn Thr  Ser Ala Ala Leu          
1240                 1245                 1250                          

tcg  tcg ctg aca gtg aac  ggc acg aag gtc tcc  gac tcc gtg ctc      4018
Ser  Ser Leu Thr Val Asn  Gly Thr Lys Val Ser  Asp Ser Val Leu          
1255                 1260                 1265                          

gcc  gcc ggc tcc tac aac  acg ccc gcg atc atc  gcg gac gtc aaa      4063
Ala  Ala Gly Ser Tyr Asn  Thr Pro Ala Ile Ile  Ala Asp Val Lys          
1270                 1275                 1280                          

gcc  gag ggc gaa ggc aac  gcc agc gtc acc gtg  ctg ccc gcg cac      4108
Ala  Glu Gly Glu Gly Asn  Ala Ser Val Thr Val  Leu Pro Ala His          
1285                 1290                 1295                          

gac  aac gtg atc cgc gtg  atc acc gag tcc gag  gac cac gtc acg      4153
Asp  Asn Val Ile Arg Val  Ile Thr Glu Ser Glu  Asp His Val Thr          
1300                 1305                 1310                          

cgc  aag acc ttc acc atc  aac ctg ggc acg gag  cag gaa ttc ccc      4198
Arg  Lys Thr Phe Thr Ile  Asn Leu Gly Thr Glu  Gln Glu Phe Pro          
1315                 1320                 1325                          

gca  gac tcc gat gaa cgc  gac tac ccg gcc gcc  gac atg acg gtc      4243
Ala  Asp Ser Asp Glu Arg  Asp Tyr Pro Ala Ala  Asp Met Thr Val          
1330                 1335                 1340                          

acc  gtg ggc agc gaa cag  acg tcc ggc acc gcg  acc gaa ggc ccg      4288
Thr  Val Gly Ser Glu Gln  Thr Ser Gly Thr Ala  Thr Glu Gly Pro          
1345                 1350                 1355                          

aag  aaa ttc gcg gtc gac  ggc aac acc agc acg  tac tgg cat tcc      4333
Lys  Lys Phe Ala Val Asp  Gly Asn Thr Ser Thr  Tyr Trp His Ser          
1360                 1365                 1370                          

aac  tgg acg ccc acc acc  gtg aac gac ctg tgg  atc gcc ttc gag      4378
Asn  Trp Thr Pro Thr Thr  Val Asn Asp Leu Trp  Ile Ala Phe Glu          
1375                 1380                 1385                          

ctc  cag aaa ccc acc aag  ctc gac gcg ctg cgc  tac ctg ccg cgc      4423
Leu  Gln Lys Pro Thr Lys  Leu Asp Ala Leu Arg  Tyr Leu Pro Arg          
1390                 1395                 1400                          

ccc  gcg ggc agc aag aac  ggc tcc gtc acc gaa  tac aag gtt cag      4468
Pro  Ala Gly Ser Lys Asn  Gly Ser Val Thr Glu  Tyr Lys Val Gln          
1405                 1410                 1415                          

gtc  agc gat gac ggc acc  aac tgg acc gac gcg  ggc tcc ggc aca      4513
Val  Ser Asp Asp Gly Thr  Asn Trp Thr Asp Ala  Gly Ser Gly Thr          
1420                 1425                 1430                          

tgg  acc acc gat tac ggc  tgg aag ctc gcc gag  ttc aat cag ccg      4558
Trp  Thr Thr Asp Tyr Gly  Trp Lys Leu Ala Glu  Phe Asn Gln Pro          
1435                 1440                 1445                          

gtg  acc acc aag cac gtg  cgg ctc aag gcc gtc  cac acc tat gcg      4603
Val  Thr Thr Lys His Val  Arg Leu Lys Ala Val  His Thr Tyr Ala          
1450                 1455                 1460                          

gat  tcc ggc aac gac aag  ttc atg tcc gcc tcc  gaa atc cgc ctg      4648
Asp  Ser Gly Asn Asp Lys  Phe Met Ser Ala Ser  Glu Ile Arg Leu          
1465                 1470                 1475                          

cgc  aag gcc gtc gac acc  acc gac atc agc ggc  gcg acc gtg acc      4693
Arg  Lys Ala Val Asp Thr  Thr Asp Ile Ser Gly  Ala Thr Val Thr          
1480                 1485                 1490                          

gtg  ccc gcc aag ctg acc  gtc gac cgg gtg gac  gcc gac cat ccc      4738
Val  Pro Ala Lys Leu Thr  Val Asp Arg Val Asp  Ala Asp His Pro          
1495                 1500                 1505                          

gcc  acc ttc gcc acg aag  gac gtg acg gtg acg  ttg ggc gac gcc      4783
Ala  Thr Phe Ala Thr Lys  Asp Val Thr Val Thr  Leu Gly Asp Ala          
1510                 1515                 1520                          

acg  ctg cgc tac ggc gtg  gac tac ctg ctc gac  tac gcg ggc aac      4828
Thr  Leu Arg Tyr Gly Val  Asp Tyr Leu Leu Asp  Tyr Ala Gly Asn          
1525                 1530                 1535                          

acc  gcc gtc ggc aag gcc  acg gtg acc gtg cgc  ggc atc gac aag      4873
Thr  Ala Val Gly Lys Ala  Thr Val Thr Val Arg  Gly Ile Asp Lys          
1540                 1545                 1550                          

tac  tcc ggc acc gtc gcc  aag acg ttc acc atc  gaa ctg aag aac      4918
Tyr  Ser Gly Thr Val Ala  Lys Thr Phe Thr Ile  Glu Leu Lys Asn          
1555                 1560                 1565                          

gcc  ccg gcg ccg gaa ccg  acg ctg acc tcg gtg  agc gtc aag acc      4963
Ala  Pro Ala Pro Glu Pro  Thr Leu Thr Ser Val  Ser Val Lys Thr          
1570                 1575                 1580                          

aag  cct tcc aag ctg acc  tat gtg gtc ggc gac  gcg ttc gac ccg      5008
Lys  Pro Ser Lys Leu Thr  Tyr Val Val Gly Asp  Ala Phe Asp Pro          
1585                 1590                 1595                          

gca  gga ctg gtg ctg cag  cac gac aga cag gcc  gat cgc ccc cca      5053
Ala  Gly Leu Val Leu Gln  His Asp Arg Gln Ala  Asp Arg Pro Pro          
1600                 1605                 1610                          

cag  cca ctt gtt gga gaa  cag gcc gac gaa cgc  gga ctg acg tgc      5098
Gln  Pro Leu Val Gly Glu  Gln Ala Asp Glu Arg  Gly Leu Thr Cys          
1615                 1620                 1625                          

gga  acg cga tgc gat cgc  gtt gaa cag ctg cgc  aaa cac gag aat      5143
Gly  Thr Arg Cys Asp Arg  Val Glu Gln Leu Arg  Lys His Glu Asn          
1630                 1635                 1640                          

cgt  gaa gcc cat cgt acg  ggc ctc gat cat ctg  gaa ttc gtg ggt      5188
Arg  Glu Ala His Arg Thr  Gly Leu Asp His Leu  Glu Phe Val Gly          
1645                 1650                 1655                          

gcc  gcc gat gga gcg gtc  ggt gaa cag gcc acc  ttc aag gtg cat      5233
Ala  Ala Asp Gly Ala Val  Gly Glu Gln Ala Thr  Phe Lys Val His          
1660                 1665                 1670                          

gtc  cat gcc gat caa ggt  gac ggc cgc cat gat  gat gcc gat gaa      5278
Val  His Ala Asp Gln Gly  Asp Gly Arg His Asp  Asp Ala Asp Glu          
1675                 1680                 1685                          

cgc  gat atc gat cca cat  gtc cct gtc gat cac  gcg gtc ggt gag      5323
Arg  Asp Ile Asp Pro His  Val Pro Val Asp His  Ala Val Gly Glu          
1690                 1695                 1700                          

ctt  gcg cgg gct gcg tgc  cat cac gtc atc ggt  ctg cgg gtc gac      5368
Leu  Ala Arg Ala Ala Cys  His His Val Ile Gly  Leu Arg Val Asp          
1705                 1710                 1715                          

acc  cat cgc ctc aag gca  tcc ggc ttc cag atc  ccc gcc gac gac      5413
Thr  His Arg Leu Lys Ala  Ser Gly Phe Gln Ile  Pro Ala Asp Asp          
1720                 1725                 1730                          

atg  gcc gag atc gac cgc  atc acc ggc ttc cac  cgc ttc gag cgc      5458
Met  Ala Glu Ile Asp Arg  Ile Thr Gly Phe His  Arg Phe Glu Arg          
1735                 1740                 1745                          

cac  gtc ggc tga cgtgattggg cttccccgct gtctggtgcc ggctcgcga         5509
His  Val Gly                                                            
1750                                                                    


<210>  2
<211>  1752
<212>  PRT
<213>  Bifidobacterium bifidum

<400>  2

Met Ala Val Arg Arg Leu Gly Gly Arg Ile Val Ala Phe Ala Ala Thr 
1               5                   10                  15      


Val Ala Leu Ser Ile Pro Leu Gly Leu Leu Thr Asn Ser Ala Trp Ala 
            20                  25                  30          


Val Glu Asp Ala Thr Arg Ser Asp Ser Thr Thr Gln Met Ser Ser Thr 
        35                  40                  45              


Pro Glu Val Val Tyr Ser Ser Ala Val Asp Ser Lys Gln Asn Arg Thr 
    50                  55                  60                  


Ser Asp Phe Asp Ala Asn Trp Lys Phe Met Leu Ser Asp Ser Val Gln 
65                  70                  75                  80  


Ala Gln Asp Pro Ala Phe Asp Asp Ser Ala Trp Gln Gln Val Asp Leu 
                85                  90                  95      


Pro His Asp Tyr Ser Ile Thr Gln Lys Tyr Ser Gln Ser Asn Glu Ala 
            100                 105                 110         


Glu Ser Ala Tyr Leu Pro Gly Gly Thr Gly Trp Tyr Arg Lys Ser Phe 
        115                 120                 125             


Thr Ile Asp Arg Asp Leu Ala Gly Lys Arg Ile Ala Ile Asn Phe Asp 
    130                 135                 140                 


Gly Val Tyr Met Asn Ala Thr Val Trp Phe Asn Gly Val Lys Leu Gly 
145                 150                 155                 160 


Thr His Pro Tyr Gly Tyr Ser Pro Phe Ser Phe Asp Leu Thr Gly Asn 
                165                 170                 175     


Ala Lys Phe Gly Gly Glu Asn Thr Ile Val Val Lys Val Glu Asn Arg 
            180                 185                 190         


Leu Pro Ser Ser Arg Trp Tyr Ser Gly Ser Gly Ile Tyr Arg Asp Val 
        195                 200                 205             


Thr Leu Thr Val Thr Asp Gly Val His Val Gly Asn Asn Gly Val Ala 
    210                 215                 220                 


Ile Lys Thr Pro Ser Leu Ala Thr Gln Asn Gly Gly Asp Val Thr Met 
225                 230                 235                 240 


Asn Leu Thr Thr Lys Val Ala Asn Asp Thr Glu Ala Ala Ala Asn Ile 
                245                 250                 255     


Thr Leu Lys Gln Thr Val Phe Pro Lys Gly Gly Lys Thr Asp Ala Ala 
            260                 265                 270         


Ile Gly Thr Val Thr Thr Ala Ser Lys Ser Ile Ala Ala Gly Ala Ser 
        275                 280                 285             


Ala Asp Val Thr Ser Thr Ile Thr Ala Ala Ser Pro Lys Leu Trp Ser 
    290                 295                 300                 


Ile Lys Asn Pro Asn Leu Tyr Thr Val Arg Thr Glu Val Leu Asn Gly 
305                 310                 315                 320 


Gly Lys Val Leu Asp Thr Tyr Asp Thr Glu Tyr Gly Phe Arg Trp Thr 
                325                 330                 335     


Gly Phe Asp Ala Thr Ser Gly Phe Ser Leu Asn Gly Glu Lys Val Lys 
            340                 345                 350         


Leu Lys Gly Val Ser Met His His Asp Gln Gly Ser Leu Gly Ala Val 
        355                 360                 365             


Ala Asn Arg Arg Ala Ile Glu Arg Gln Val Glu Ile Leu Gln Lys Met 
    370                 375                 380                 


Gly Val Asn Ser Ile Arg Thr Thr His Asn Pro Ala Ala Lys Ala Leu 
385                 390                 395                 400 


Ile Asp Val Cys Asn Glu Lys Gly Val Leu Val Val Glu Glu Val Phe 
                405                 410                 415     


Asp Met Trp Asn Arg Ser Lys Asn Gly Asn Thr Glu Asp Tyr Gly Lys 
            420                 425                 430         


Trp Phe Gly Gln Ala Ile Ala Gly Asp Asn Ala Val Leu Gly Gly Asp 
        435                 440                 445             


Lys Asp Glu Thr Trp Ala Lys Phe Asp Leu Thr Ser Thr Ile Asn Arg 
    450                 455                 460                 


Asp Arg Asn Ala Pro Ser Val Ile Met Trp Ser Leu Gly Asn Glu Met 
465                 470                 475                 480 


Met Glu Gly Ile Ser Gly Ser Val Ser Gly Phe Pro Ala Thr Ser Ala 
                485                 490                 495     


Lys Leu Val Ala Trp Thr Lys Ala Ala Asp Ser Thr Arg Pro Met Thr 
            500                 505                 510         


Tyr Gly Asp Asn Lys Ile Lys Ala Asn Trp Asn Glu Ser Asn Thr Met 
        515                 520                 525             


Gly Asp Asn Leu Thr Ala Asn Gly Gly Val Val Gly Thr Asn Tyr Ser 
    530                 535                 540                 


Asp Gly Ala Asn Tyr Asp Lys Ile Arg Thr Thr His Pro Ser Trp Ala 
545                 550                 555                 560 


Ile Tyr Gly Ser Glu Thr Ala Ser Ala Ile Asn Ser Arg Gly Ile Tyr 
                565                 570                 575     


Asn Arg Thr Thr Gly Gly Ala Gln Ser Ser Asp Lys Gln Leu Thr Ser 
            580                 585                 590         


Tyr Asp Asn Ser Ala Val Gly Trp Gly Ala Val Ala Ser Ser Ala Trp 
        595                 600                 605             


Tyr Asp Val Val Gln Arg Asp Phe Val Ala Gly Thr Tyr Val Trp Thr 
    610                 615                 620                 


Gly Phe Asp Tyr Leu Gly Glu Pro Thr Pro Trp Asn Gly Thr Gly Ser 
625                 630                 635                 640 


Gly Ala Val Gly Ser Leu Ala Val Ala Glu Glu Leu Val Leu Arg His 
                645                 650                 655     


Arg Arg His Arg Arg Leu Pro Glu Asp Thr Tyr Tyr Phe Tyr Gln Ser 
            660                 665                 670         


Gln Trp Asn Asp Asp Val His Thr Leu His Ile Leu Pro Ala Trp Asn 
        675                 680                 685             


Glu Asn Val Val Ala Lys Gly Ser Gly Asn Asn Val Pro Val Val Val 
    690                 695                 700                 


Tyr Thr Asp Ala Ala Lys Val Lys Leu Tyr Phe Thr Pro Lys Gly Ser 
705                 710                 715                 720 


Thr Glu Lys Arg Leu Ile Gly Glu Lys Ser Phe Thr Lys Lys Thr Thr 
                725                 730                 735     


Ala Ala Gly Tyr Thr Tyr Gln Val Tyr Glu Gly Ser Asp Lys Asp Ser 
            740                 745                 750         


Thr Ala His Lys Asn Met Tyr Leu Thr Trp Asn Val Pro Trp Ala Glu 
        755                 760                 765             


Gly Thr Ile Ser Ala Glu Ala Tyr Asp Glu Asn Asn Arg Leu Ile Pro 
    770                 775                 780                 


Glu Gly Ser Thr Glu Gly Asn Ala Ser Val Thr Thr Thr Gly Lys Ala 
785                 790                 795                 800 


Ala Lys Leu Lys Ala Asp Ala Asp Arg Lys Thr Ile Thr Ala Asp Gly 
                805                 810                 815     


Lys Asp Leu Ser Tyr Ile Glu Val Asp Val Thr Asp Ala Asn Gly His 
            820                 825                 830         


Ile Val Pro Asp Ala Ala Asn Arg Val Thr Phe Asp Val Lys Gly Ala 
        835                 840                 845             


Gly Lys Leu Val Gly Val Asp Asn Gly Ser Ser Pro Asp His Asp Ser 
    850                 855                 860                 


Tyr Gln Ala Asp Asn Arg Lys Ala Phe Ser Gly Lys Val Leu Ala Ile 
865                 870                 875                 880 


Val Gln Ser Thr Lys Glu Ala Gly Glu Ile Thr Val Thr Ala Lys Ala 
                885                 890                 895     


Asp Gly Leu Gln Ser Ser Thr Val Lys Ile Ala Thr Thr Ala Val Pro 
            900                 905                 910         


Gly Thr Ser Thr Glu Lys Thr Val Arg Ser Phe Tyr Tyr Ser Arg Asn 
        915                 920                 925             


Tyr Tyr Val Lys Thr Gly Asn Lys Pro Ile Leu Pro Ser Asp Val Glu 
    930                 935                 940                 


Val Arg Tyr Ser Asp Gly Thr Ser Asp Arg Gln Asn Val Thr Trp Asp 
945                 950                 955                 960 


Ala Val Ser Asp Asp Gln Ile Ala Lys Ala Gly Ser Phe Ser Val Ala 
                965                 970                 975     


Gly Thr Val Ala Gly Gln Lys Ile Ser Val Arg Val Thr Met Ile Asp 
            980                 985                 990         


Glu Ile Gly Ala Leu Leu Asn Tyr  Ser Ala Ser Thr Pro  Val Gly Thr 
        995                 1000                 1005             


Pro Ala  Val Leu Pro Gly Ser  Arg Pro Ala Val Leu  Pro Asp Gly 
    1010                 1015                 1020             


Thr Val  Thr Ser Ala Asn Phe  Ala Val His Trp Thr  Lys Pro Ala 
    1025                 1030                 1035             


Asp Thr  Val Tyr Asn Thr Ala  Gly Thr Val Lys Val  Pro Gly Thr 
    1040                 1045                 1050             


Ala Thr  Val Phe Gly Lys Glu  Phe Lys Val Thr Ala  Thr Ile Arg 
    1055                 1060                 1065             


Val Gln  Arg Ser Gln Val Thr  Ile Gly Ser Ser Val  Ser Gly Asn 
    1070                 1075                 1080             


Ala Leu  Arg Leu Thr Gln Asn  Ile Pro Ala Asp Lys  Gln Ser Asp 
    1085                 1090                 1095             


Thr Leu  Asp Ala Ile Lys Asp  Gly Ser Thr Thr Val  Asp Ala Asn 
    1100                 1105                 1110             


Thr Gly  Gly Gly Ala Asn Pro  Ser Ala Trp Thr Asn  Trp Ala Tyr 
    1115                 1120                 1125             


Ser Lys  Ala Gly His Asn Thr  Ala Glu Ile Thr Phe  Glu Tyr Ala 
    1130                 1135                 1140             


Thr Glu  Gln Gln Leu Gly Gln  Ile Val Met Tyr Phe  Phe Arg Asp 
    1145                 1150                 1155             


Ser Asn  Ala Val Arg Phe Pro  Asp Ala Gly Lys Thr  Lys Ile Gln 
    1160                 1165                 1170             


Ile Ser  Ala Asp Gly Lys Asn  Trp Thr Asp Leu Ala  Ala Thr Glu 
    1175                 1180                 1185             


Thr Ile  Ala Ala Gln Glu Ser  Ser Asp Arg Val Lys  Pro Tyr Thr 
    1190                 1195                 1200             


Tyr Asp  Phe Ala Pro Val Gly  Ala Thr Phe Val Lys  Val Thr Val 
    1205                 1210                 1215             


Thr Asn  Ala Asp Thr Thr Thr  Pro Ser Gly Val Val  Cys Ala Gly 
    1220                 1225                 1230             


Leu Thr  Glu Ile Glu Leu Lys  Thr Ala Thr Ser Lys  Phe Val Thr 
    1235                 1240                 1245             


Asn Thr  Ser Ala Ala Leu Ser  Ser Leu Thr Val Asn  Gly Thr Lys 
    1250                 1255                 1260             


Val Ser  Asp Ser Val Leu Ala  Ala Gly Ser Tyr Asn  Thr Pro Ala 
    1265                 1270                 1275             


Ile Ile  Ala Asp Val Lys Ala  Glu Gly Glu Gly Asn  Ala Ser Val 
    1280                 1285                 1290             


Thr Val  Leu Pro Ala His Asp  Asn Val Ile Arg Val  Ile Thr Glu 
    1295                 1300                 1305             


Ser Glu  Asp His Val Thr Arg  Lys Thr Phe Thr Ile  Asn Leu Gly 
    1310                 1315                 1320             


Thr Glu  Gln Glu Phe Pro Ala  Asp Ser Asp Glu Arg  Asp Tyr Pro 
    1325                 1330                 1335             


Ala Ala  Asp Met Thr Val Thr  Val Gly Ser Glu Gln  Thr Ser Gly 
    1340                 1345                 1350             


Thr Ala  Thr Glu Gly Pro Lys  Lys Phe Ala Val Asp  Gly Asn Thr 
    1355                 1360                 1365             


Ser Thr  Tyr Trp His Ser Asn  Trp Thr Pro Thr Thr  Val Asn Asp 
    1370                 1375                 1380             


Leu Trp  Ile Ala Phe Glu Leu  Gln Lys Pro Thr Lys  Leu Asp Ala 
    1385                 1390                 1395             


Leu Arg  Tyr Leu Pro Arg Pro  Ala Gly Ser Lys Asn  Gly Ser Val 
    1400                 1405                 1410             


Thr Glu  Tyr Lys Val Gln Val  Ser Asp Asp Gly Thr  Asn Trp Thr 
    1415                 1420                 1425             


Asp Ala  Gly Ser Gly Thr Trp  Thr Thr Asp Tyr Gly  Trp Lys Leu 
    1430                 1435                 1440             


Ala Glu  Phe Asn Gln Pro Val  Thr Thr Lys His Val  Arg Leu Lys 
    1445                 1450                 1455             


Ala Val  His Thr Tyr Ala Asp  Ser Gly Asn Asp Lys  Phe Met Ser 
    1460                 1465                 1470             


Ala Ser  Glu Ile Arg Leu Arg  Lys Ala Val Asp Thr  Thr Asp Ile 
    1475                 1480                 1485             


Ser Gly  Ala Thr Val Thr Val  Pro Ala Lys Leu Thr  Val Asp Arg 
    1490                 1495                 1500             


Val Asp  Ala Asp His Pro Ala  Thr Phe Ala Thr Lys  Asp Val Thr 
    1505                 1510                 1515             


Val Thr  Leu Gly Asp Ala Thr  Leu Arg Tyr Gly Val  Asp Tyr Leu 
    1520                 1525                 1530             


Leu Asp  Tyr Ala Gly Asn Thr  Ala Val Gly Lys Ala  Thr Val Thr 
    1535                 1540                 1545             


Val Arg  Gly Ile Asp Lys Tyr  Ser Gly Thr Val Ala  Lys Thr Phe 
    1550                 1555                 1560             


Thr Ile  Glu Leu Lys Asn Ala  Pro Ala Pro Glu Pro  Thr Leu Thr 
    1565                 1570                 1575             


Ser Val  Ser Val Lys Thr Lys  Pro Ser Lys Leu Thr  Tyr Val Val 
    1580                 1585                 1590             


Gly Asp  Ala Phe Asp Pro Ala  Gly Leu Val Leu Gln  His Asp Arg 
    1595                 1600                 1605             


Gln Ala  Asp Arg Pro Pro Gln  Pro Leu Val Gly Glu  Gln Ala Asp 
    1610                 1615                 1620             


Glu Arg  Gly Leu Thr Cys Gly  Thr Arg Cys Asp Arg  Val Glu Gln 
    1625                 1630                 1635             


Leu Arg  Lys His Glu Asn Arg  Glu Ala His Arg Thr  Gly Leu Asp 
    1640                 1645                 1650             


His Leu  Glu Phe Val Gly Ala  Ala Asp Gly Ala Val  Gly Glu Gln 
    1655                 1660                 1665             


Ala Thr  Phe Lys Val His Val  His Ala Asp Gln Gly  Asp Gly Arg 
    1670                 1675                 1680             


His Asp  Asp Ala Asp Glu Arg  Asp Ile Asp Pro His  Val Pro Val 
    1685                 1690                 1695             


Asp His  Ala Val Gly Glu Leu  Ala Arg Ala Ala Cys  His His Val 
    1700                 1705                 1710             


Ile Gly  Leu Arg Val Asp Thr  His Arg Leu Lys Ala  Ser Gly Phe 
    1715                 1720                 1725             


Gln Ile  Pro Ala Asp Asp Met  Ala Glu Ile Asp Arg  Ile Thr Gly 
    1730                 1735                 1740             


Phe His  Arg Phe Glu Arg His  Val Gly 
    1745                 1750         


