                         SEQUENCE LISTING

<110>  The Government of the United States of America as 
       represented by the Secretary of the Department of Health and 
       Human Services, Centers for Disease Control and Prevention
 
<120>  COMPOSITIONS AND METHODS RELATING TO LYME DISEASE

<130>  CDC-18352/38

<150>  61/588,820
<151>  2012-01-20

<160>  426   

<170>  PatentIn version 3.5

<210>  1
<211>  474
<212>  PRT
<213>  Borrelia burgdorferi

<400>  1

Met Glu Lys Lys Phe Phe Ser Gly Phe Leu Leu Ser Phe Leu Ala Leu 
1               5                   10                  15      


Ser Ile Gly Phe Phe Ile Gly Met His Tyr Leu Ala Ser Asn Arg Ser 
            20                  25                  30          


Asn Ile Val Phe Ala Glu Glu Lys Asp Asn Thr Val Arg Ala Leu Gln 
        35                  40                  45              


Asp Ser Phe Arg Glu Val Ser Lys Lys Ile Leu Pro Ser Ser Val Glu 
    50                  55                  60                  


Val His Ala Thr Gly Val Ile Lys Gln Ser Phe Pro Ile Pro Phe Phe 
65                  70                  75                  80  


Phe Phe Asp Met Pro Glu Phe Asp Ser Glu Arg Lys Ser Asn Trp Ala 
                85                  90                  95      


Gly Ser Gly Val Ile Ile Gly Arg Asp Ser Gln Lys Lys Ser Leu Phe 
            100                 105                 110         


Tyr Val Val Thr Asn Ser His Val Val Asp Lys Ala Thr Glu Leu Glu 
        115                 120                 125             


Val Val Ser Tyr Asp Lys Lys Lys His Lys Ala Lys Leu Ile Gly Lys 
    130                 135                 140                 


Asp Glu Lys Lys Asp Ile Ala Leu Ile Ser Phe Glu Ser Asp Asp Ala 
145                 150                 155                 160 


Thr Ile Lys Val Ala Asp Leu Gly Asp Ser Asp Lys Leu Glu Ile Gly 
                165                 170                 175     


Asp Trp Val Met Ala Val Gly Ser Pro Phe Gln Phe Ser Phe Thr Val 
            180                 185                 190         


Thr Ala Gly Ile Val Ser Gly Leu Gln Arg Ser Ala Asn Pro Asn Leu 
        195                 200                 205             


Gln Ser Arg Asn Leu Phe Ile Gln Thr Asp Ala Ala Ile Asn Arg Gly 
    210                 215                 220                 


Asn Ser Gly Gly Pro Leu Val Asn Ile Lys Gly Glu Val Ile Gly Ile 
225                 230                 235                 240 


Asn Ala Trp Ile Ala Ser Asn Ser Gly Gly Asn Ile Gly Leu Gly Phe 
                245                 250                 255     


Ala Ile Pro Val Asn Asn Ile Lys Ser Thr Val Asp Phe Phe Leu Lys 
            260                 265                 270         


Gly Lys Lys Ile Glu Ser Ala Trp Leu Gly Ile Ser Phe Tyr Pro Leu 
        275                 280                 285             


Lys Thr Arg Asp Ser Glu Val Leu Lys Ser Leu Gly Val Glu Ser Asn 
    290                 295                 300                 


Asp Val Ser Ala Ala Ile Ile Ala Ser Leu Tyr Pro Gly Ser Pro Ala 
305                 310                 315                 320 


Val Lys Ser Gly Leu Arg Ala Gly Asp Ile Ile Met Lys Val Asn Gly 
                325                 330                 335     


Val Ser Met Ser Val Phe Gln Asp Val Thr Ser Tyr Ile Ser Asp Phe 
            340                 345                 350         


Tyr Ala Gly Glu Lys Val Asn Val Glu Ile Leu Arg Gly Asn Val Lys 
        355                 360                 365             


Lys Asn Ile Glu Ile Val Leu Ala Val Arg Pro Lys Asp Lys Glu Leu 
    370                 375                 380                 


Ser Ser Ser Lys Met Leu Pro Gly Phe Val Val Tyr Pro Leu Val Glu 
385                 390                 395                 400 


Asp Ile Lys Ala Gln Leu Asn Leu Arg Asn Trp Ile Lys Gly Val Val 
                405                 410                 415     


Val Asp Tyr Ile Asp Lys Asn Leu Ala Ser Asn Ile Lys Met Lys Ser 
            420                 425                 430         


Gly Asp Val Ile Leu Ser Val Asn Ser Lys Ser Val Ser Asn Leu Arg 
        435                 440                 445             


Glu Phe Tyr Asp Ala Leu Glu Val Gly Lys Asn Thr Tyr Lys Ile Leu 
    450                 455                 460                 


Arg Gly Asn Asp Ser Phe Lys Ile Thr Phe 
465                 470                 


<210>  2
<211>  1425
<212>  DNA
<213>  Borrelia burgdorferi

<400>  2
ctaaaatgta attttaaaag aatcgtttcc tctcaaaatt ttataagtat tttttccaac       60

ctcaagagca tcataaaatt ctcttaaatt agaaacactt tttgaattta cagaaagaat      120

tacatctcct gatttcattt taatatttga tgctaaattt ttatcaatat aatcaacaac      180

aacaccttta atccaatttc ttaaattaag ctgagcttta atatcctcaa ccaatggata      240

cacaacaaag cctggaagca tctttgaaga agaaagctct ttatccttag gtctaacagc      300

aagaacaatc tcaatatttt ttttgacatt gcctcttaag atttctacat ttactttctc      360

accagcataa aaatcactaa tatatgatgt aacatcttga aaaacgctca tggaaacccc      420

attaaccttc ataataatat cccctgccct aagccctgat ttaacagcgg gtgaacccgg      480

ataaagagaa gcaataattg cagctgaaac atcattactt tcaaccccta agctttttag      540

cacctcagaa tctcttgtct ttagcggata aaaagaaatt ccaagccaag ccgattcaat      600

ttttttacct ttaaggaaaa aatctacagt gcttttaata ttgttaacag gaattgcaaa      660

acccaaccca atatttccgc cagaatttga agctatccaa gcattaattc caataacctc      720

gccctttata tttacaagag gaccacctga attacccctg ttgattgcag catcggtttg      780

aataaacaga ttccttgatt gcaaattagg atttgcagaa cgttgcaatc cacttacaat      840

acctgctgta actgtaaaac taaattgaaa agggctgccc actgccataa cccaatcacc      900

tatttcaagc ttatcactat ctccaagatc agctacttta atagttgcgt catcactttc      960

aaagctaata agggcaatat cctttttttc atctttgcca attaacttag ccttgtgctt     1020

ttttttatca taagatacaa cttcaagttc agttgcctta tctaccacat gactattcgt     1080

aaccacataa aataatgatt ttttttgaga atctctacca attattactc cagaccccgc     1140

ccaattgctt tttctctcag aatcaaattc tggcatatca aaaaagaaaa atggaatagg     1200

aaaactctgc ttgattaccc ctgttgcatg aacttccaca gatgatggta aaattttctt     1260

ggaaacctct ctaaaagaat cttgtaaggc tcgtacggta ttgtcctttt cttctgcaaa     1320

aacaatgttg cttctattag aagctaaata atgcatccca ataaaaaatc caatactcaa     1380

agccaaaaaa ctaagaagaa atccagaaaa aaactttttt tccac                     1425


<210>  3
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant Borrelia burdorferi HtrA S226A

<400>  3

Met Glu Lys Lys Phe Phe Ser Gly Phe Leu Leu Ser Phe Leu Ala Leu 
1               5                   10                  15      


Ser Ile Gly Phe Phe Ile Gly Met His Tyr Leu Ala Ser Asn Arg Ser 
            20                  25                  30          


Asn Ile Val Phe Ala Glu Glu Lys Asp Asn Thr Val Arg Ala Leu Gln 
        35                  40                  45              


Asp Ser Phe Arg Glu Val Ser Lys Lys Ile Leu Pro Ser Ser Val Glu 
    50                  55                  60                  


Val His Ala Thr Gly Val Ile Lys Gln Ser Phe Pro Ile Pro Phe Phe 
65                  70                  75                  80  


Phe Phe Asp Met Pro Glu Phe Asp Ser Glu Arg Lys Ser Asn Trp Ala 
                85                  90                  95      


Gly Ser Gly Val Ile Ile Gly Arg Asp Ser Gln Lys Lys Ser Leu Phe 
            100                 105                 110         


Tyr Val Val Thr Asn Ser His Val Val Asp Lys Ala Thr Glu Leu Glu 
        115                 120                 125             


Val Val Ser Tyr Asp Lys Lys Lys His Lys Ala Lys Leu Ile Gly Lys 
    130                 135                 140                 


Asp Glu Lys Lys Asp Ile Ala Leu Ile Ser Phe Glu Ser Asp Asp Ala 
145                 150                 155                 160 


Thr Ile Lys Val Ala Asp Leu Gly Asp Ser Asp Lys Leu Glu Ile Gly 
                165                 170                 175     


Asp Trp Val Met Ala Val Gly Ser Pro Phe Gln Phe Ser Phe Thr Val 
            180                 185                 190         


Thr Ala Gly Ile Val Ser Gly Leu Gln Arg Ser Ala Asn Pro Asn Leu 
        195                 200                 205             


Gln Ser Arg Asn Leu Phe Ile Gln Thr Asp Ala Ala Ile Asn Arg Gly 
    210                 215                 220                 


Asn Ala Gly Gly Pro Leu Val Asn Ile Lys Gly Glu Val Ile Gly Ile 
225                 230                 235                 240 


Asn Ala Trp Ile Ala Ser Asn Ser Gly Gly Asn Ile Gly Leu Gly Phe 
                245                 250                 255     


Ala Ile Pro Val Asn Asn Ile Lys Ser Thr Val Asp Phe Phe Leu Lys 
            260                 265                 270         


Gly Lys Lys Ile Glu Ser Ala Trp Leu Gly Ile Ser Phe Tyr Pro Leu 
        275                 280                 285             


Lys Thr Arg Asp Ser Glu Val Leu Lys Ser Leu Gly Val Glu Ser Asn 
    290                 295                 300                 


Asp Val Ser Ala Ala Ile Ile Ala Ser Leu Tyr Pro Gly Ser Pro Ala 
305                 310                 315                 320 


Val Lys Ser Gly Leu Arg Ala Gly Asp Ile Ile Met Lys Val Asn Gly 
                325                 330                 335     


Val Ser Met Ser Val Phe Gln Asp Val Thr Ser Tyr Ile Ser Asp Phe 
            340                 345                 350         


Tyr Ala Gly Glu Lys Val Asn Val Glu Ile Leu Arg Gly Asn Val Lys 
        355                 360                 365             


Lys Asn Ile Glu Ile Val Leu Ala Val Arg Pro Lys Asp Lys Glu Leu 
    370                 375                 380                 


Ser Ser Ser Lys Met Leu Pro Gly Phe Val Val Tyr Pro Leu Val Glu 
385                 390                 395                 400 


Asp Ile Lys Ala Gln Leu Asn Leu Arg Asn Trp Ile Lys Gly Val Val 
                405                 410                 415     


Val Asp Tyr Ile Asp Lys Asn Leu Ala Ser Asn Ile Lys Met Lys Ser 
            420                 425                 430         


Gly Asp Val Ile Leu Ser Val Asn Ser Lys Ser Val Ser Asn Leu Arg 
        435                 440                 445             


Glu Phe Tyr Asp Ala Leu Glu Val Gly Lys Asn Thr Tyr Lys Ile Leu 
    450                 455                 460                 


Arg Gly Asn Asp Ser Phe Lys Ile Thr Phe 
465                 470                 


<210>  4
<211>  1425
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding mutant Borrelia burgdoreri HtrA 
       S226A

<400>  4
ctaaaatgta attttaaaag aatcgtttcc tctcaaaatt ttataagtat tttttccaac       60

ctcaagagca tcataaaatt ctcttaaatt agaaacactt tttgaattta cagaaagaat      120

tacatctcct gatttcattt taatatttga tgctaaattt ttatcaatat aatcaacaac      180

aacaccttta atccaatttc ttaaattaag ctgagcttta atatcctcaa ccaatggata      240

cacaacaaag cctggaagca tctttgaaga agaaagctct ttatccttag gtctaacagc      300

aagaacaatc tcaatatttt ttttgacatt gcctcttaag atttctacat ttactttctc      360

accagcataa aaatcactaa tatatgatgt aacatcttga aaaacgctca tggaaacccc      420

attaaccttc ataataatat cccctgccct aagccctgat ttaacagcgg gtgaacccgg      480

ataaagagaa gcaataattg cagctgaaac atcattactt tcaaccccta agctttttag      540

cacctcagaa tctcttgtct ttagcggata aaaagaaatt ccaagccaag ccgattcaat      600

ttttttacct ttaaggaaaa aatctacagt gcttttaata ttgttaacag gaattgcaaa      660

acccaaccca atatttccgc cagaatttga agctatccaa gcattaattc caataacctc      720

gccctttata tttacaagag gaccacctgc attacccctg ttgattgcag catcggtttg      780

aataaacaga ttccttgatt gcaaattagg atttgcagaa cgttgcaatc cacttacaat      840

acctgctgta actgtaaaac taaattgaaa agggctgccc actgccataa cccaatcacc      900

tatttcaagc ttatcactat ctccaagatc agctacttta atagttgcgt catcactttc      960

aaagctaata agggcaatat cctttttttc atctttgcca attaacttag ccttgtgctt     1020

ttttttatca taagatacaa cttcaagttc agttgcctta tctaccacat gactattcgt     1080

aaccacataa aataatgatt ttttttgaga atctctacca attattactc cagaccccgc     1140

ccaattgctt tttctctcag aatcaaattc tggcatatca aaaaagaaaa atggaatagg     1200

aaaactctgc ttgattaccc ctgttgcatg aacttccaca gatgatggta aaattttctt     1260

ggaaacctct ctaaaagaat cttgtaaggc tcgtacggta ttgtcctttt cttctgcaaa     1320

aacaatgttg cttctattag aagctaaata atgcatccca ataaaaaatc caatactcaa     1380

agccaaaaaa ctaagaagaa atccagaaaa aaactttttt tccac                     1425


<210>  5
<211>  474
<212>  PRT
<213>  Borrelia garinii

<400>  5

Met Glu Lys Lys Phe Phe Ser Gly Phe Ile Leu Ser Phe Leu Ala Leu 
1               5                   10                  15      


Gly Ile Gly Phe Phe Ile Gly Met His Tyr Leu Asp Ser Asn Arg Ser 
            20                  25                  30          


Asn Ile Val Phe Ala Glu Glu Lys Asp Asn Thr Val Gln Ala Leu Gln 
        35                  40                  45              


Asp Ser Phe Arg Glu Val Ser Lys Lys Ile Leu Ser Ser Ser Val Glu 
    50                  55                  60                  


Val His Ala Thr Gly Val Ile Lys Gln Ser Phe Pro Ile Pro Phe Phe 
65                  70                  75                  80  


Phe Phe Asp Met Pro Glu Phe Asp Ser Glu Arg Lys Ser Asn Trp Ala 
                85                  90                  95      


Gly Ser Gly Val Ile Ile Gly Arg Asp Ser Gln Lys Lys Ser Leu Phe 
            100                 105                 110         


Tyr Val Val Thr Asn Ser His Val Val Asp Lys Ala Thr Glu Leu Glu 
        115                 120                 125             


Val Val Ser Tyr Asp Lys Lys Lys His Lys Ala Lys Leu Ile Gly Lys 
    130                 135                 140                 


Asp Glu Lys Lys Asp Ile Ala Leu Ile Ser Phe Glu Ser Asp Asp Ala 
145                 150                 155                 160 


Thr Ile Lys Val Ala Asp Leu Gly Asp Ser Asp Lys Leu Glu Ile Gly 
                165                 170                 175     


Asp Trp Val Met Ala Val Gly Ser Pro Phe Gln Phe Ser Phe Thr Val 
            180                 185                 190         


Thr Ala Gly Ile Val Ser Gly Leu Gln Arg Ser Ala Asn Pro Asn Leu 
        195                 200                 205             


Gln Ser Arg Asn Leu Phe Ile Gln Thr Asp Ala Ala Ile Asn Arg Gly 
    210                 215                 220                 


Asn Ser Gly Gly Pro Leu Val Asn Ile Lys Gly Glu Val Ile Gly Ile 
225                 230                 235                 240 


Asn Ala Trp Ile Ala Ser Asn Ser Gly Gly Asn Ile Gly Leu Gly Phe 
                245                 250                 255     


Ala Ile Pro Val Asn Asn Ile Lys Ser Thr Val Asp Phe Phe Leu Lys 
            260                 265                 270         


Gly Lys Lys Ile Glu Ser Ala Trp Leu Gly Ile Ser Phe Tyr Pro Leu 
        275                 280                 285             


Lys Thr Arg Asp Ser Glu Val Leu Lys Ser Leu Gly Val Glu Gly Lys 
    290                 295                 300                 


Asp Val Ser Ala Ala Ile Ile Ala Ser Leu Tyr Pro Gly Ser Pro Ala 
305                 310                 315                 320 


Val Lys Ser Gly Leu Lys Ala Gly Asp Ile Ile Val Lys Val Asn Gly 
                325                 330                 335     


Val Ser Met Ser Val Phe Gln Asp Val Thr Ser Tyr Ile Ser Asp Phe 
            340                 345                 350         


Tyr Ala Gly Glu Lys Val Asn Val Glu Ile Leu Arg Gly Asn Val Lys 
        355                 360                 365             


Lys Asn Ile Glu Ile Val Leu Ala Val Arg Pro Lys Asp Lys Glu Leu 
    370                 375                 380                 


Ser Ser Ser Lys Met Leu Pro Gly Phe Ile Val Tyr Pro Leu Val Glu 
385                 390                 395                 400 


Asp Ile Lys Ala Gln Leu Asn Leu Arg Asn Trp Ile Lys Gly Val Val 
                405                 410                 415     


Val Asp Tyr Ile Asp Lys Asn Leu Ala Ser Asn Ile Lys Met Lys Ser 
            420                 425                 430         


Gly Asp Val Ile Leu Ser Val Asn Ser Gln Ser Val Ser Asn Leu Arg 
        435                 440                 445             


Glu Phe Tyr Asp Ala Leu Lys Ile Gly Lys Asn Thr Tyr Lys Ile Leu 
    450                 455                 460                 


Arg Gly Asn Asp Ser Phe Lys Ile Ser Phe 
465                 470                 


<210>  6
<211>  1425
<212>  DNA
<213>  Borrelia garinii

<400>  6
ctaaaacgaa attttaaaag aatcatttcc tcttaaaatt ttataagtat tttttccaat       60

cttaagagca tcataaaatt ctcttaaatt agaaacactt tgtgaattta cagaaagaat      120

cacatctcct gatttcatct taatatttga tgctaaattt ttatcaatat aatcaacaac      180

aacgccttta atccaatttc ttaaattaag ctgagcttta atatcctcaa ctaatggata      240

cacaataaaa cctggaagca ttttggaaga agaaagttct ttatccttag gtctaacagc      300

aagaacaatc tcaatatttt ttttgacatt acctcttaaa atttctacat ttactttctc      360

accagcataa aaatcgctaa tatatgatgt aacatcttga aaaacactca tagaaacccc      420

attaacctta acaataatat cgcctgcttt aagccctgac ttaacggcag gtgaacctgg      480

ataaagagag gcaataattg cagctgaaac atccttacct tcaactccta agctttttag      540

tacttcagaa tctcttgtct ttaaaggata aaaagaaatt ccaagccatg ctgattcaat      600

ttttttacct ttaagaaaaa aatctacagt acttttaata ttattaacag gaattgcaaa      660

acctaaccca atatttcctc cagaatttga agctatccaa gcattaattc caataacttc      720

accttttata tttacaagag gaccgcctga attacctctg ttgattgcag catcagtttg      780

aataaataaa ttccttgatt gtaaattagg atttgcagag cgttgtaatc cacttacaat      840

acctgctgta actgtaaaac taaattgaaa aggactacct actgccataa cccaatcacc      900

tatttcaagc ttatcactat ctccaagatc agctacttta atagttgcat catcactttc      960

aaagctaata agagcaatat cttttttttc atctttgcca attaacttag ccttgtgctt     1020

ttttttatca taagacacaa cttcaagttc agttgcctta tctactacat gactatttgt     1080

aaccacataa aataatgatt ttttttgaga atccctacca attattactc cagaccctgc     1140

ccaattgctt tttctctcag aatcaaattc tggcatatca aaaaagaaaa atggaatagg     1200

aaaactctgt ttaattaccc cggttgcatg aacttctacg gacgatgata aaattttctt     1260

ggaaacttcc ctaaaagaat cttgtaaggc ttgtactgta ttgtcttttt cttctgcaaa     1320

aacaatattg cttctattag aatctaagta atgcattcca ataaaaaaac caatacctaa     1380

agccaaaaaa ctgagaataa atccagaaaa aaactttttt tccac                     1425


<210>  7
<211>  474
<212>  PRT
<213>  Borrelia afzelii

<400>  7

Met Glu Lys Lys Phe Phe Ser Gly Phe Ile Leu Ser Phe Leu Ala Leu 
1               5                   10                  15      


Gly Ile Gly Phe Phe Ile Gly Met His Tyr Leu Asp Ser Asn Arg Ser 
            20                  25                  30          


Asn Ile Val Phe Ala Glu Glu Lys Gly Asn Thr Val Gln Thr Leu Gln 
        35                  40                  45              


Asp Ser Phe Arg Glu Val Ser Lys Lys Ile Leu Pro Ser Ser Val Glu 
    50                  55                  60                  


Val His Ala Thr Gly Val Ile Lys Gln Ser Phe Pro Ile Pro Phe Phe 
65                  70                  75                  80  


Phe Phe Asp Met Pro Glu Phe Asp Ser Glu Arg Lys Ser Asn Trp Ala 
                85                  90                  95      


Gly Ser Gly Val Ile Ile Gly Arg Asp Ser Lys Asn Lys Ser Leu Phe 
            100                 105                 110         


Tyr Val Val Thr Asn Ser His Val Val Asp Lys Ala Thr Glu Leu Glu 
        115                 120                 125             


Val Val Ser Tyr Asp Lys Lys Lys His Lys Ala Lys Leu Ile Gly Lys 
    130                 135                 140                 


Asp Glu Lys Lys Asp Ile Ala Leu Ile Ser Phe Glu Ser Asp Asp Ala 
145                 150                 155                 160 


Thr Ile Lys Val Ala Asp Leu Gly Asp Ser Asp Lys Leu Glu Ile Gly 
                165                 170                 175     


Asp Trp Val Met Ala Val Gly Ser Pro Phe Gln Phe Ser Phe Thr Val 
            180                 185                 190         


Thr Ala Gly Ile Val Ser Gly Leu Gln Arg Ser Ala Asn Pro Asn Leu 
        195                 200                 205             


Gln Ser Arg Asn Leu Phe Ile Gln Thr Asp Ala Ala Ile Asn Arg Gly 
    210                 215                 220                 


Asn Ser Gly Gly Pro Leu Val Asn Thr Lys Gly Glu Val Ile Gly Ile 
225                 230                 235                 240 


Asn Ala Trp Ile Ala Ser Asn Ser Gly Gly Asn Ile Gly Leu Gly Phe 
                245                 250                 255     


Ala Ile Pro Val Asn Asn Ile Lys Ser Thr Val Asp Phe Phe Leu Lys 
            260                 265                 270         


Gly Lys Lys Ile Glu Ser Ala Trp Leu Gly Ile Ser Phe Tyr Pro Leu 
        275                 280                 285             


Lys Thr Arg Asp Pro Glu Val Leu Lys Ser Leu Gly Val Glu Gly Asp 
    290                 295                 300                 


Asp Val Pro Ala Ala Ile Ile Ala Ser Leu Tyr Pro Gly Ser Pro Ala 
305                 310                 315                 320 


Ile Lys Ser Gly Leu Arg Ala Gly Asp Ile Ile Val Lys Val Asn Gly 
                325                 330                 335     


Val Pro Met Ser Val Phe Gln Asp Val Thr Ser Tyr Ile Ser Asp Phe 
            340                 345                 350         


Tyr Ala Gly Glu Lys Ile Asn Val Glu Ile Leu Arg Gly Asn Val Lys 
        355                 360                 365             


Lys Asn Ile Glu Ile Ile Leu Ala Val Arg Pro Lys Asp Lys Glu Leu 
    370                 375                 380                 


Ser Ser Ser Lys Met Phe Pro Gly Phe Val Val Tyr Pro Leu Val Glu 
385                 390                 395                 400 


Asp Ile Lys Ala Gln Leu Asn Leu Arg Asn Trp Thr Lys Gly Val Val 
                405                 410                 415     


Val Asp Tyr Ile Asp Lys Asn Leu Ala Ser Asn Ile Lys Met Lys Ser 
            420                 425                 430         


Gly Asp Val Ile Leu Ser Val Asn Ser Lys Ser Val Ser Asn Leu Arg 
        435                 440                 445             


Glu Phe Tyr Asp Ala Leu Glu Ile Gly Lys Asn Thr Tyr Asn Ile Leu 
    450                 455                 460                 


Arg Gly Asn Asp Ser Phe Lys Ile Ser Phe 
465                 470                 


<210>  8
<211>  1425
<212>  DNA
<213>  Borrelia afzelii

<400>  8
ctaaaacgaa attttaaaag aatcgtttcc tcttaaaatg ttataagtat tttttccaat       60

ctcaagagca tcataaaatt ctcttaaatt agaaacactt tttgaattta cagaaagaat      120

tacatctcct gatttcatct taatatttga tgctaaattt ttatcaatat aatcaacaac      180

aacgccttta gtccaatttc ttaaattaag ctgagcttta atatcttcaa ctaatggata      240

cacaacaaaa cctggaaaca tttttgaaga agaaagctct ttgtccttgg gtctaacagc      300

aagaataatc tcaatattct ttttaacatt acctcttaaa atttctacat tgattttctc      360

accagcataa aaatcgctaa tatatgatgt aacgtcttga aaaacactca tgggaactcc      420

attaaccttc acaataatgt ctcccgctct aagccctgac ttaatagcag gtgaacctgg      480

ataaagagaa gcaataattg cagctggaac atcatcacct tcaaccccca agctttttag      540

cacttcagga tctcttgtct ttaatgggta aaaagaaatt ccaagccatg ctgattcaat      600

ttttttacct ttaaggaaaa aatctacggt acttttaata ttgttaacag gaattgcaaa      660

acctaaccca atatttccac cagaatttga agctatccaa gcattaatcc caataacttc      720

accttttgta tttacaagag gtccacctga attacctcta ttgattgcag catcagtttg      780

aataaataaa tttcttgatt gtaaattagg atttgcagaa cgttgcaatc cacttacaat      840

acctgctgta actgtaaaac taaattgaaa agggctacct accgccataa cccaatcacc      900

tatttcaagc ttatcactat ccccaagatc agccacttta atagttgcat catcactttc      960

aaagctaata agcgcaatat cctttttttc atctttgcca attaacttag ccttatgctt     1020

tttcttatca taagatacaa cttcaagttc agttgcctta tctactacat gactattggt     1080

aactacataa aataatgatt tatttttgga atctctacca attattactc cagaccctgc     1140

ccaattgctt tttctctcag aatcaaattc tggcatatca aaaaagaaaa atggaatagg     1200

aaaactctgc ttaattaccc ctgttgcatg aacttctaca gatgatggta aaattttctt     1260

ggaaacttct ctaaaagagt cttgcaaggt ttgtactgta ttaccctttt cttctgcaaa     1320

aacaatgtta cttctattag aatctaaata atgcatccca ataaaaaacc caatacccaa     1380

agctaaaaag ctaagaataa atccagaaaa aaactttttt tccac                     1425


<210>  9
<211>  437
<212>  PRT
<213>  Borrelia burgdorferi

<400>  9

Glu Glu Lys Asp Asn Thr Val Arg Ala Leu Gln Asp Ser Phe Arg Glu 
1               5                   10                  15      


Val Ser Lys Lys Ile Leu Pro Ser Ser Val Glu Val His Ala Thr Gly 
            20                  25                  30          


Val Ile Lys Gln Ser Phe Pro Ile Pro Phe Phe Phe Phe Asp Met Pro 
        35                  40                  45              


Glu Phe Asp Ser Glu Arg Lys Ser Asn Trp Ala Gly Ser Gly Val Ile 
    50                  55                  60                  


Ile Gly Arg Asp Ser Gln Lys Lys Ser Leu Phe Tyr Val Val Thr Asn 
65                  70                  75                  80  


Ser His Val Val Asp Lys Ala Thr Glu Leu Glu Val Val Ser Tyr Asp 
                85                  90                  95      


Lys Lys Lys His Lys Ala Lys Leu Ile Gly Lys Asp Glu Lys Lys Asp 
            100                 105                 110         


Ile Ala Leu Ile Ser Phe Glu Ser Asp Asp Ala Thr Ile Lys Val Ala 
        115                 120                 125             


Asp Leu Gly Asp Ser Asp Lys Leu Glu Ile Gly Asp Trp Val Met Ala 
    130                 135                 140                 


Val Gly Ser Pro Phe Gln Phe Ser Phe Thr Val Thr Ala Gly Ile Val 
145                 150                 155                 160 


Ser Gly Leu Gln Arg Ser Ala Asn Pro Asn Leu Gln Ser Arg Asn Leu 
                165                 170                 175     


Phe Ile Gln Thr Asp Ala Ala Ile Asn Arg Gly Asn Ser Gly Gly Pro 
            180                 185                 190         


Leu Val Asn Ile Lys Gly Glu Val Ile Gly Ile Asn Ala Trp Ile Ala 
        195                 200                 205             


Ser Asn Ser Gly Gly Asn Ile Gly Leu Gly Phe Ala Ile Pro Val Asn 
    210                 215                 220                 


Asn Ile Lys Ser Thr Val Asp Phe Phe Leu Lys Gly Lys Lys Ile Glu 
225                 230                 235                 240 


Ser Ala Trp Leu Gly Ile Ser Phe Tyr Pro Leu Lys Thr Arg Asp Ser 
                245                 250                 255     


Glu Val Leu Lys Ser Leu Gly Val Glu Ser Asn Asp Val Ser Ala Ala 
            260                 265                 270         


Ile Ile Ala Ser Leu Tyr Pro Gly Ser Pro Ala Val Lys Ser Gly Leu 
        275                 280                 285             


Arg Ala Gly Asp Ile Ile Met Lys Val Asn Gly Val Ser Met Ser Val 
    290                 295                 300                 


Phe Gln Asp Val Thr Ser Tyr Ile Ser Asp Phe Tyr Ala Gly Glu Lys 
305                 310                 315                 320 


Val Asn Val Glu Ile Leu Arg Gly Asn Val Lys Lys Asn Ile Glu Ile 
                325                 330                 335     


Val Leu Ala Val Arg Pro Lys Asp Lys Glu Leu Ser Ser Ser Lys Met 
            340                 345                 350         


Leu Pro Gly Phe Val Val Tyr Pro Leu Val Glu Asp Ile Lys Ala Gln 
        355                 360                 365             


Leu Asn Leu Arg Asn Trp Ile Lys Gly Val Val Val Asp Tyr Ile Asp 
    370                 375                 380                 


Lys Asn Leu Ala Ser Asn Ile Lys Met Lys Ser Gly Asp Val Ile Leu 
385                 390                 395                 400 


Ser Val Asn Ser Lys Ser Val Ser Asn Leu Arg Glu Phe Tyr Asp Ala 
                405                 410                 415     


Leu Glu Val Gly Lys Asn Thr Tyr Lys Ile Leu Arg Gly Asn Asp Ser 
            420                 425                 430         


Phe Lys Ile Thr Phe 
        435         


<210>  10
<211>  1314
<212>  DNA
<213>  Borrelia burgdorferi

<400>  10
ctaaaatgta attttaaaag aatcgtttcc tctcaaaatt ttataagtat tttttccaac       60

ctcaagagca tcataaaatt ctcttaaatt agaaacactt tttgaattta cagaaagaat      120

tacatctcct gatttcattt taatatttga tgctaaattt ttatcaatat aatcaacaac      180

aacaccttta atccaatttc ttaaattaag ctgagcttta atatcctcaa ccaatggata      240

cacaacaaag cctggaagca tctttgaaga agaaagctct ttatccttag gtctaacagc      300

aagaacaatc tcaatatttt ttttgacatt gcctcttaag atttctacat ttactttctc      360

accagcataa aaatcactaa tatatgatgt aacatcttga aaaacgctca tggaaacccc      420

attaaccttc ataataatat cccctgccct aagccctgat ttaacagcgg gtgaacccgg      480

ataaagagaa gcaataattg cagctgaaac atcattactt tcaaccccta agctttttag      540

cacctcagaa tctcttgtct ttagcggata aaaagaaatt ccaagccaag ccgattcaat      600

ttttttacct ttaaggaaaa aatctacagt gcttttaata ttgttaacag gaattgcaaa      660

acccaaccca atatttccgc cagaatttga agctatccaa gcattaattc caataacctc      720

gccctttata tttacaagag gaccacctga attacccctg ttgattgcag catcggtttg      780

aataaacaga ttccttgatt gcaaattagg atttgcagaa cgttgcaatc cacttacaat      840

acctgctgta actgtaaaac taaattgaaa agggctgccc actgccataa cccaatcacc      900

tatttcaagc ttatcactat ctccaagatc agctacttta atagttgcgt catcactttc      960

aaagctaata agggcaatat cctttttttc atctttgcca attaacttag ccttgtgctt     1020

ttttttatca taagatacaa cttcaagttc agttgcctta tctaccacat gactattcgt     1080

aaccacataa aataatgatt ttttttgaga atctctacca attattactc cagaccccgc     1140

ccaattgctt tttctctcag aatcaaattc tggcatatca aaaaagaaaa atggaatagg     1200

aaaactctgc ttgattaccc ctgttgcatg aacttccaca gatgatggta aaattttctt     1260

ggaaacctct ctaaaagaat cttgtaaggc tcgtacggta ttgtcctttt cttc           1314


<210>  11
<211>  437
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Borrelia burgdorferi HtrA S226A mutant without signal sequence

<400>  11

Glu Glu Lys Asp Asn Thr Val Arg Ala Leu Gln Asp Ser Phe Arg Glu 
1               5                   10                  15      


Val Ser Lys Lys Ile Leu Pro Ser Ser Val Glu Val His Ala Thr Gly 
            20                  25                  30          


Val Ile Lys Gln Ser Phe Pro Ile Pro Phe Phe Phe Phe Asp Met Pro 
        35                  40                  45              


Glu Phe Asp Ser Glu Arg Lys Ser Asn Trp Ala Gly Ser Gly Val Ile 
    50                  55                  60                  


Ile Gly Arg Asp Ser Gln Lys Lys Ser Leu Phe Tyr Val Val Thr Asn 
65                  70                  75                  80  


Ser His Val Val Asp Lys Ala Thr Glu Leu Glu Val Val Ser Tyr Asp 
                85                  90                  95      


Lys Lys Lys His Lys Ala Lys Leu Ile Gly Lys Asp Glu Lys Lys Asp 
            100                 105                 110         


Ile Ala Leu Ile Ser Phe Glu Ser Asp Asp Ala Thr Ile Lys Val Ala 
        115                 120                 125             


Asp Leu Gly Asp Ser Asp Lys Leu Glu Ile Gly Asp Trp Val Met Ala 
    130                 135                 140                 


Val Gly Ser Pro Phe Gln Phe Ser Phe Thr Val Thr Ala Gly Ile Val 
145                 150                 155                 160 


Ser Gly Leu Gln Arg Ser Ala Asn Pro Asn Leu Gln Ser Arg Asn Leu 
                165                 170                 175     


Phe Ile Gln Thr Asp Ala Ala Ile Asn Arg Gly Asn Ala Gly Gly Pro 
            180                 185                 190         


Leu Val Asn Ile Lys Gly Glu Val Ile Gly Ile Asn Ala Trp Ile Ala 
        195                 200                 205             


Ser Asn Ser Gly Gly Asn Ile Gly Leu Gly Phe Ala Ile Pro Val Asn 
    210                 215                 220                 


Asn Ile Lys Ser Thr Val Asp Phe Phe Leu Lys Gly Lys Lys Ile Glu 
225                 230                 235                 240 


Ser Ala Trp Leu Gly Ile Ser Phe Tyr Pro Leu Lys Thr Arg Asp Ser 
                245                 250                 255     


Glu Val Leu Lys Ser Leu Gly Val Glu Ser Asn Asp Val Ser Ala Ala 
            260                 265                 270         


Ile Ile Ala Ser Leu Tyr Pro Gly Ser Pro Ala Val Lys Ser Gly Leu 
        275                 280                 285             


Arg Ala Gly Asp Ile Ile Met Lys Val Asn Gly Val Ser Met Ser Val 
    290                 295                 300                 


Phe Gln Asp Val Thr Ser Tyr Ile Ser Asp Phe Tyr Ala Gly Glu Lys 
305                 310                 315                 320 


Val Asn Val Glu Ile Leu Arg Gly Asn Val Lys Lys Asn Ile Glu Ile 
                325                 330                 335     


Val Leu Ala Val Arg Pro Lys Asp Lys Glu Leu Ser Ser Ser Lys Met 
            340                 345                 350         


Leu Pro Gly Phe Val Val Tyr Pro Leu Val Glu Asp Ile Lys Ala Gln 
        355                 360                 365             


Leu Asn Leu Arg Asn Trp Ile Lys Gly Val Val Val Asp Tyr Ile Asp 
    370                 375                 380                 


Lys Asn Leu Ala Ser Asn Ile Lys Met Lys Ser Gly Asp Val Ile Leu 
385                 390                 395                 400 


Ser Val Asn Ser Lys Ser Val Ser Asn Leu Arg Glu Phe Tyr Asp Ala 
                405                 410                 415     


Leu Glu Val Gly Lys Asn Thr Tyr Lys Ile Leu Arg Gly Asn Asp Ser 
            420                 425                 430         


Phe Lys Ile Thr Phe 
        435         


<210>  12
<211>  1314
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence encoding Borrelia burgdorferi HtrA S226A 
       mutant without the signal peptide

<400>  12
ctaaaatgta attttaaaag aatcgtttcc tctcaaaatt ttataagtat tttttccaac       60

ctcaagagca tcataaaatt ctcttaaatt agaaacactt tttgaattta cagaaagaat      120

tacatctcct gatttcattt taatatttga tgctaaattt ttatcaatat aatcaacaac      180

aacaccttta atccaatttc ttaaattaag ctgagcttta atatcctcaa ccaatggata      240

cacaacaaag cctggaagca tctttgaaga agaaagctct ttatccttag gtctaacagc      300

aagaacaatc tcaatatttt ttttgacatt gcctcttaag atttctacat ttactttctc      360

accagcataa aaatcactaa tatatgatgt aacatcttga aaaacgctca tggaaacccc      420

attaaccttc ataataatat cccctgccct aagccctgat ttaacagcgg gtgaacccgg      480

ataaagagaa gcaataattg cagctgaaac atcattactt tcaaccccta agctttttag      540

cacctcagaa tctcttgtct ttagcggata aaaagaaatt ccaagccaag ccgattcaat      600

ttttttacct ttaaggaaaa aatctacagt gcttttaata ttgttaacag gaattgcaaa      660

acccaaccca atatttccgc cagaatttga agctatccaa gcattaattc caataacctc      720

gccctttata tttacaagag gaccacctgc attacccctg ttgattgcag catcggtttg      780

aataaacaga ttccttgatt gcaaattagg atttgcagaa cgttgcaatc cacttacaat      840

acctgctgta actgtaaaac taaattgaaa agggctgccc actgccataa cccaatcacc      900

tatttcaagc ttatcactat ctccaagatc agctacttta atagttgcgt catcactttc      960

aaagctaata agggcaatat cctttttttc atctttgcca attaacttag ccttgtgctt     1020

ttttttatca taagatacaa cttcaagttc agttgcctta tctaccacat gactattcgt     1080

aaccacataa aataatgatt ttttttgaga atctctacca attattactc cagaccccgc     1140

ccaattgctt tttctctcag aatcaaattc tggcatatca aaaaagaaaa atggaatagg     1200

aaaactctgc ttgattaccc ctgttgcatg aacttccaca gatgatggta aaattttctt     1260

ggaaacctct ctaaaagaat cttgtaaggc tcgtacggta ttgtcctttt cttc           1314


<210>  13
<211>  437
<212>  PRT
<213>  Borrelia garinii

<400>  13

Glu Glu Lys Asp Asn Thr Val Gln Ala Leu Gln Asp Ser Phe Arg Glu 
1               5                   10                  15      


Val Ser Lys Lys Ile Leu Ser Ser Ser Val Glu Val His Ala Thr Gly 
            20                  25                  30          


Val Ile Lys Gln Ser Phe Pro Ile Pro Phe Phe Phe Phe Asp Met Pro 
        35                  40                  45              


Glu Phe Asp Ser Glu Arg Lys Ser Asn Trp Ala Gly Ser Gly Val Ile 
    50                  55                  60                  


Ile Gly Arg Asp Ser Gln Lys Lys Ser Leu Phe Tyr Val Val Thr Asn 
65                  70                  75                  80  


Ser His Val Val Asp Lys Ala Thr Glu Leu Glu Val Val Ser Tyr Asp 
                85                  90                  95      


Lys Lys Lys His Lys Ala Lys Leu Ile Gly Lys Asp Glu Lys Lys Asp 
            100                 105                 110         


Ile Ala Leu Ile Ser Phe Glu Ser Asp Asp Ala Thr Ile Lys Val Ala 
        115                 120                 125             


Asp Leu Gly Asp Ser Asp Lys Leu Glu Ile Gly Asp Trp Val Met Ala 
    130                 135                 140                 


Val Gly Ser Pro Phe Gln Phe Ser Phe Thr Val Thr Ala Gly Ile Val 
145                 150                 155                 160 


Ser Gly Leu Gln Arg Ser Ala Asn Pro Asn Leu Gln Ser Arg Asn Leu 
                165                 170                 175     


Phe Ile Gln Thr Asp Ala Ala Ile Asn Arg Gly Asn Ser Gly Gly Pro 
            180                 185                 190         


Leu Val Asn Ile Lys Gly Glu Val Ile Gly Ile Asn Ala Trp Ile Ala 
        195                 200                 205             


Ser Asn Ser Gly Gly Asn Ile Gly Leu Gly Phe Ala Ile Pro Val Asn 
    210                 215                 220                 


Asn Ile Lys Ser Thr Val Asp Phe Phe Leu Lys Gly Lys Lys Ile Glu 
225                 230                 235                 240 


Ser Ala Trp Leu Gly Ile Ser Phe Tyr Pro Leu Lys Thr Arg Asp Ser 
                245                 250                 255     


Glu Val Leu Lys Ser Leu Gly Val Glu Gly Lys Asp Val Ser Ala Ala 
            260                 265                 270         


Ile Ile Ala Ser Leu Tyr Pro Gly Ser Pro Ala Val Lys Ser Gly Leu 
        275                 280                 285             


Lys Ala Gly Asp Ile Ile Val Lys Val Asn Gly Val Ser Met Ser Val 
    290                 295                 300                 


Phe Gln Asp Val Thr Ser Tyr Ile Ser Asp Phe Tyr Ala Gly Glu Lys 
305                 310                 315                 320 


Val Asn Val Glu Ile Leu Arg Gly Asn Val Lys Lys Asn Ile Glu Ile 
                325                 330                 335     


Val Leu Ala Val Arg Pro Lys Asp Lys Glu Leu Ser Ser Ser Lys Met 
            340                 345                 350         


Leu Pro Gly Phe Ile Val Tyr Pro Leu Val Glu Asp Ile Lys Ala Gln 
        355                 360                 365             


Leu Asn Leu Arg Asn Trp Ile Lys Gly Val Val Val Asp Tyr Ile Asp 
    370                 375                 380                 


Lys Asn Leu Ala Ser Asn Ile Lys Met Lys Ser Gly Asp Val Ile Leu 
385                 390                 395                 400 


Ser Val Asn Ser Gln Ser Val Ser Asn Leu Arg Glu Phe Tyr Asp Ala 
                405                 410                 415     


Leu Lys Ile Gly Lys Asn Thr Tyr Lys Ile Leu Arg Gly Asn Asp Ser 
            420                 425                 430         


Phe Lys Ile Ser Phe 
        435         


<210>  14
<211>  1314
<212>  DNA
<213>  Borrelia garinii

<400>  14
ctaaaacgaa attttaaaag aatcatttcc tcttaaaatt ttataagtat tttttccaat       60

cttaagagca tcataaaatt ctcttaaatt agaaacactt tgtgaattta cagaaagaat      120

cacatctcct gatttcatct taatatttga tgctaaattt ttatcaatat aatcaacaac      180

aacgccttta atccaatttc ttaaattaag ctgagcttta atatcctcaa ctaatggata      240

cacaataaaa cctggaagca ttttggaaga agaaagttct ttatccttag gtctaacagc      300

aagaacaatc tcaatatttt ttttgacatt acctcttaaa atttctacat ttactttctc      360

accagcataa aaatcgctaa tatatgatgt aacatcttga aaaacactca tagaaacccc      420

attaacctta acaataatat cgcctgcttt aagccctgac ttaacggcag gtgaacctgg      480

ataaagagag gcaataattg cagctgaaac atccttacct tcaactccta agctttttag      540

tacttcagaa tctcttgtct ttaaaggata aaaagaaatt ccaagccatg ctgattcaat      600

ttttttacct ttaagaaaaa aatctacagt acttttaata ttattaacag gaattgcaaa      660

acctaaccca atatttcctc cagaatttga agctatccaa gcattaattc caataacttc      720

accttttata tttacaagag gaccgcctga attacctctg ttgattgcag catcagtttg      780

aataaataaa ttccttgatt gtaaattagg atttgcagag cgttgtaatc cacttacaat      840

acctgctgta actgtaaaac taaattgaaa aggactacct actgccataa cccaatcacc      900

tatttcaagc ttatcactat ctccaagatc agctacttta atagttgcat catcactttc      960

aaagctaata agagcaatat cttttttttc atctttgcca attaacttag ccttgtgctt     1020

ttttttatca taagacacaa cttcaagttc agttgcctta tctactacat gactatttgt     1080

aaccacataa aataatgatt ttttttgaga atccctacca attattactc cagaccctgc     1140

ccaattgctt tttctctcag aatcaaattc tggcatatca aaaaagaaaa atggaatagg     1200

aaaactctgt ttaattaccc cggttgcatg aacttctacg gacgatgata aaattttctt     1260

ggaaacttcc ctaaaagaat cttgtaaggc ttgtactgta ttgtcttttt cttc           1314


<210>  15
<211>  437
<212>  PRT
<213>  Borrelia afzelii

<400>  15

Glu Glu Lys Gly Asn Thr Val Gln Thr Leu Gln Asp Ser Phe Arg Glu 
1               5                   10                  15      


Val Ser Lys Lys Ile Leu Pro Ser Ser Val Glu Val His Ala Thr Gly 
            20                  25                  30          


Val Ile Lys Gln Ser Phe Pro Ile Pro Phe Phe Phe Phe Asp Met Pro 
        35                  40                  45              


Glu Phe Asp Ser Glu Arg Lys Ser Asn Trp Ala Gly Ser Gly Val Ile 
    50                  55                  60                  


Ile Gly Arg Asp Ser Lys Asn Lys Ser Leu Phe Tyr Val Val Thr Asn 
65                  70                  75                  80  


Ser His Val Val Asp Lys Ala Thr Glu Leu Glu Val Val Ser Tyr Asp 
                85                  90                  95      


Lys Lys Lys His Lys Ala Lys Leu Ile Gly Lys Asp Glu Lys Lys Asp 
            100                 105                 110         


Ile Ala Leu Ile Ser Phe Glu Ser Asp Asp Ala Thr Ile Lys Val Ala 
        115                 120                 125             


Asp Leu Gly Asp Ser Asp Lys Leu Glu Ile Gly Asp Trp Val Met Ala 
    130                 135                 140                 


Val Gly Ser Pro Phe Gln Phe Ser Phe Thr Val Thr Ala Gly Ile Val 
145                 150                 155                 160 


Ser Gly Leu Gln Arg Ser Ala Asn Pro Asn Leu Gln Ser Arg Asn Leu 
                165                 170                 175     


Phe Ile Gln Thr Asp Ala Ala Ile Asn Arg Gly Asn Ser Gly Gly Pro 
            180                 185                 190         


Leu Val Asn Thr Lys Gly Glu Val Ile Gly Ile Asn Ala Trp Ile Ala 
        195                 200                 205             


Ser Asn Ser Gly Gly Asn Ile Gly Leu Gly Phe Ala Ile Pro Val Asn 
    210                 215                 220                 


Asn Ile Lys Ser Thr Val Asp Phe Phe Leu Lys Gly Lys Lys Ile Glu 
225                 230                 235                 240 


Ser Ala Trp Leu Gly Ile Ser Phe Tyr Pro Leu Lys Thr Arg Asp Pro 
                245                 250                 255     


Glu Val Leu Lys Ser Leu Gly Val Glu Gly Asp Asp Val Pro Ala Ala 
            260                 265                 270         


Ile Ile Ala Ser Leu Tyr Pro Gly Ser Pro Ala Ile Lys Ser Gly Leu 
        275                 280                 285             


Arg Ala Gly Asp Ile Ile Val Lys Val Asn Gly Val Pro Met Ser Val 
    290                 295                 300                 


Phe Gln Asp Val Thr Ser Tyr Ile Ser Asp Phe Tyr Ala Gly Glu Lys 
305                 310                 315                 320 


Ile Asn Val Glu Ile Leu Arg Gly Asn Val Lys Lys Asn Ile Glu Ile 
                325                 330                 335     


Ile Leu Ala Val Arg Pro Lys Asp Lys Glu Leu Ser Ser Ser Lys Met 
            340                 345                 350         


Phe Pro Gly Phe Val Val Tyr Pro Leu Val Glu Asp Ile Lys Ala Gln 
        355                 360                 365             


Leu Asn Leu Arg Asn Trp Thr Lys Gly Val Val Val Asp Tyr Ile Asp 
    370                 375                 380                 


Lys Asn Leu Ala Ser Asn Ile Lys Met Lys Ser Gly Asp Val Ile Leu 
385                 390                 395                 400 


Ser Val Asn Ser Lys Ser Val Ser Asn Leu Arg Glu Phe Tyr Asp Ala 
                405                 410                 415     


Leu Glu Ile Gly Lys Asn Thr Tyr Asn Ile Leu Arg Gly Asn Asp Ser 
            420                 425                 430         


Phe Lys Ile Ser Phe 
        435         


<210>  16
<211>  1314
<212>  DNA
<213>  Borrelia afzelii

<400>  16
ctaaaacgaa attttaaaag aatcgtttcc tcttaaaatg ttataagtat tttttccaat       60

ctcaagagca tcataaaatt ctcttaaatt agaaacactt tttgaattta cagaaagaat      120

tacatctcct gatttcatct taatatttga tgctaaattt ttatcaatat aatcaacaac      180

aacgccttta gtccaatttc ttaaattaag ctgagcttta atatcttcaa ctaatggata      240

cacaacaaaa cctggaaaca tttttgaaga agaaagctct ttgtccttgg gtctaacagc      300

aagaataatc tcaatattct ttttaacatt acctcttaaa atttctacat tgattttctc      360

accagcataa aaatcgctaa tatatgatgt aacgtcttga aaaacactca tgggaactcc      420

attaaccttc acaataatgt ctcccgctct aagccctgac ttaatagcag gtgaacctgg      480

ataaagagaa gcaataattg cagctggaac atcatcacct tcaaccccca agctttttag      540

cacttcagga tctcttgtct ttaatgggta aaaagaaatt ccaagccatg ctgattcaat      600

ttttttacct ttaaggaaaa aatctacggt acttttaata ttgttaacag gaattgcaaa      660

acctaaccca atatttccac cagaatttga agctatccaa gcattaatcc caataacttc      720

accttttgta tttacaagag gtccacctga attacctcta ttgattgcag catcagtttg      780

aataaataaa tttcttgatt gtaaattagg atttgcagaa cgttgcaatc cacttacaat      840

acctgctgta actgtaaaac taaattgaaa agggctacct accgccataa cccaatcacc      900

tatttcaagc ttatcactat ccccaagatc agccacttta atagttgcat catcactttc      960

aaagctaata agcgcaatat cctttttttc atctttgcca attaacttag ccttatgctt     1020

tttcttatca taagatacaa cttcaagttc agttgcctta tctactacat gactattggt     1080

aactacataa aataatgatt tatttttgga atctctacca attattactc cagaccctgc     1140

ccaattgctt tttctctcag aatcaaattc tggcatatca aaaaagaaaa atggaatagg     1200

aaaactctgc ttaattaccc ctgttgcatg aacttctaca gatgatggta aaattttctt     1260

ggaaacttct ctaaaagagt cttgcaaggt ttgtactgta ttaccctttt cttc           1314


<210>  17
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Borrelia burgdorferi HtrA amino acid sequence without signal 
       peptide and without the PDZ2 domain

<400>  17

Glu Glu Lys Asp Asn Thr Val Arg Ala Leu Gln Asp Ser Phe Arg Glu 
1               5                   10                  15      


Val Ser Lys Lys Ile Leu Pro Ser Ser Val Glu Val His Ala Thr Gly 
            20                  25                  30          


Val Ile Lys Gln Ser Phe Pro Ile Pro Phe Phe Phe Phe Asp Met Pro 
        35                  40                  45              


Glu Phe Asp Ser Glu Arg Lys Ser Asn Trp Ala Gly Ser Gly Val Ile 
    50                  55                  60                  


Ile Gly Arg Asp Ser Gln Lys Lys Ser Leu Phe Tyr Val Val Thr Asn 
65                  70                  75                  80  


Ser His Val Val Asp Lys Ala Thr Glu Leu Glu Val Val Ser Tyr Asp 
                85                  90                  95      


Lys Lys Lys His Lys Ala Lys Leu Ile Gly Lys Asp Glu Lys Lys Asp 
            100                 105                 110         


Ile Ala Leu Ile Ser Phe Glu Ser Asp Asp Ala Thr Ile Lys Val Ala 
        115                 120                 125             


Asp Leu Gly Asp Ser Asp Lys Leu Glu Ile Gly Asp Trp Val Met Ala 
    130                 135                 140                 


Val Gly Ser Pro Phe Gln Phe Ser Phe Thr Val Thr Ala Gly Ile Val 
145                 150                 155                 160 


Ser Gly Leu Gln Arg Ser Ala Asn Pro Asn Leu Gln Ser Arg Asn Leu 
                165                 170                 175     


Phe Ile Gln Thr Asp Ala Ala Ile Asn Arg Gly Asn Ser Gly Gly Pro 
            180                 185                 190         


Leu Val Asn Ile Lys Gly Glu Val Ile Gly Ile Asn Ala Trp Ile Ala 
        195                 200                 205             


Ser Asn Ser Gly Gly Asn Ile Gly Leu Gly Phe Ala Ile Pro Val Asn 
    210                 215                 220                 


Asn Ile Lys Ser Thr Val Asp Phe Phe Leu Lys Gly Lys Lys Ile Glu 
225                 230                 235                 240 


Ser Ala Trp Leu Gly Ile Ser Phe Tyr Pro Leu Lys Thr Arg Asp Ser 
                245                 250                 255     


Glu Val Leu Lys Ser Leu Gly Val Glu Ser Asn Asp Val Ser Ala Ala 
            260                 265                 270         


Ile Ile Ala Ser Leu Tyr Pro Gly Ser Pro Ala Val Lys Ser Gly Leu 
        275                 280                 285             


Arg Ala Gly Asp Ile Ile Met Lys Val Asn Gly Val Ser Met Ser Val 
    290                 295                 300                 


Phe Gln Asp Val Thr Ser Tyr Ile Ser Asp Phe Tyr Ala Gly Glu Lys 
305                 310                 315                 320 


Val Asn Val Glu Ile Leu Arg Gly Asn Val Lys Lys Asn Ile Glu Ile 
                325                 330                 335     


<210>  18
<211>  1008
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   Nucleic acid sequence encoding Borrelia burgdorferi HtrA without
       signal peptide and without the PDZ2 domain

<400>  18
aatctcaata ttttttttga cattgcctct taagatttct acatttactt tctcaccagc       60

ataaaaatca ctaatatatg atgtaacatc ttgaaaaacg ctcatggaaa ccccattaac      120

cttcataata atatcccctg ccctaagccc tgatttaaca gcgggtgaac ccggataaag      180

agaagcaata attgcagctg aaacatcatt actttcaacc cctaagcttt ttagcacctc      240

agaatctctt gtctttagcg gataaaaaga aattccaagc caagccgatt caattttttt      300

acctttaagg aaaaaatcta cagtgctttt aatattgtta acaggaattg caaaacccaa      360

cccaatattt ccgccagaat ttgaagctat ccaagcatta attccaataa cctcgccctt      420

tatatttaca agaggaccac ctgaattacc cctgttgatt gcagcatcgg tttgaataaa      480

cagattcctt gattgcaaat taggatttgc agaacgttgc aatccactta caatacctgc      540

tgtaactgta aaactaaatt gaaaagggct gcccactgcc ataacccaat cacctatttc      600

aagcttatca ctatctccaa gatcagctac tttaatagtt gcgtcatcac tttcaaagct      660

aataagggca atatcctttt tttcatcttt gccaattaac ttagccttgt gctttttttt      720

atcataagat acaacttcaa gttcagttgc cttatctacc acatgactat tcgtaaccac      780

ataaaataat gatttttttt gagaatctct accaattatt actccagacc ccgcccaatt      840

gctttttctc tcagaatcaa attctggcat atcaaaaaag aaaaatggaa taggaaaact      900

ctgcttgatt acccctgttg catgaacttc cacagatgat ggtaaaattt tcttggaaac      960

ctctctaaaa gaatcttgta aggctcgtac ggtattgtcc ttttcttc                  1008


<210>  19
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of Borrelia burgdorferi HtrA S226A mutant 
       without signal peptide, and without PDZ2 domain

<400>  19

Glu Glu Lys Asp Asn Thr Val Arg Ala Leu Gln Asp Ser Phe Arg Glu 
1               5                   10                  15      


Val Ser Lys Lys Ile Leu Pro Ser Ser Val Glu Val His Ala Thr Gly 
            20                  25                  30          


Val Ile Lys Gln Ser Phe Pro Ile Pro Phe Phe Phe Phe Asp Met Pro 
        35                  40                  45              


Glu Phe Asp Ser Glu Arg Lys Ser Asn Trp Ala Gly Ser Gly Val Ile 
    50                  55                  60                  


Ile Gly Arg Asp Ser Gln Lys Lys Ser Leu Phe Tyr Val Val Thr Asn 
65                  70                  75                  80  


Ser His Val Val Asp Lys Ala Thr Glu Leu Glu Val Val Ser Tyr Asp 
                85                  90                  95      


Lys Lys Lys His Lys Ala Lys Leu Ile Gly Lys Asp Glu Lys Lys Asp 
            100                 105                 110         


Ile Ala Leu Ile Ser Phe Glu Ser Asp Asp Ala Thr Ile Lys Val Ala 
        115                 120                 125             


Asp Leu Gly Asp Ser Asp Lys Leu Glu Ile Gly Asp Trp Val Met Ala 
    130                 135                 140                 


Val Gly Ser Pro Phe Gln Phe Ser Phe Thr Val Thr Ala Gly Ile Val 
145                 150                 155                 160 


Ser Gly Leu Gln Arg Ser Ala Asn Pro Asn Leu Gln Ser Arg Asn Leu 
                165                 170                 175     


Phe Ile Gln Thr Asp Ala Ala Ile Asn Arg Gly Asn Ala Gly Gly Pro 
            180                 185                 190         


Leu Val Asn Ile Lys Gly Glu Val Ile Gly Ile Asn Ala Trp Ile Ala 
        195                 200                 205             


Ser Asn Ser Gly Gly Asn Ile Gly Leu Gly Phe Ala Ile Pro Val Asn 
    210                 215                 220                 


Asn Ile Lys Ser Thr Val Asp Phe Phe Leu Lys Gly Lys Lys Ile Glu 
225                 230                 235                 240 


Ser Ala Trp Leu Gly Ile Ser Phe Tyr Pro Leu Lys Thr Arg Asp Ser 
                245                 250                 255     


Glu Val Leu Lys Ser Leu Gly Val Glu Ser Asn Asp Val Ser Ala Ala 
            260                 265                 270         


Ile Ile Ala Ser Leu Tyr Pro Gly Ser Pro Ala Val Lys Ser Gly Leu 
        275                 280                 285             


Arg Ala Gly Asp Ile Ile Met Lys Val Asn Gly Val Ser Met Ser Val 
    290                 295                 300                 


Phe Gln Asp Val Thr Ser Tyr Ile Ser Asp Phe Tyr Ala Gly Glu Lys 
305                 310                 315                 320 


Val Asn Val Glu Ile Leu Arg Gly Asn Val Lys Lys Asn Ile Glu Ile 
                325                 330                 335     


<210>  20
<211>  1008
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence encoding Borrelia burgdorferi HtrA S226A 
       mutant without signal peptide and without the PDZ2 domain

<400>  20
aatctcaata ttttttttga cattgcctct taagatttct acatttactt tctcaccagc       60

ataaaaatca ctaatatatg atgtaacatc ttgaaaaacg ctcatggaaa ccccattaac      120

cttcataata atatcccctg ccctaagccc tgatttaaca gcgggtgaac ccggataaag      180

agaagcaata attgcagctg aaacatcatt actttcaacc cctaagcttt ttagcacctc      240

agaatctctt gtctttagcg gataaaaaga aattccaagc caagccgatt caattttttt      300

acctttaagg aaaaaatcta cagtgctttt aatattgtta acaggaattg caaaacccaa      360

cccaatattt ccgccagaat ttgaagctat ccaagcatta attccaataa cctcgccctt      420

tatatttaca agaggaccac ctgcattacc cctgttgatt gcagcatcgg tttgaataaa      480

cagattcctt gattgcaaat taggatttgc agaacgttgc aatccactta caatacctgc      540

tgtaactgta aaactaaatt gaaaagggct gcccactgcc ataacccaat cacctatttc      600

aagcttatca ctatctccaa gatcagctac tttaatagtt gcgtcatcac tttcaaagct      660

aataagggca atatcctttt tttcatcttt gccaattaac ttagccttgt gctttttttt      720

atcataagat acaacttcaa gttcagttgc cttatctacc acatgactat tcgtaaccac      780

ataaaataat gatttttttt gagaatctct accaattatt actccagacc ccgcccaatt      840

gctttttctc tcagaatcaa attctggcat atcaaaaaag aaaaatggaa taggaaaact      900

ctgcttgatt acccctgttg catgaacttc cacagatgat ggtaaaattt tcttggaaac      960

ctctctaaaa gaatcttgta aggctcgtac ggtattgtcc ttttcttc                  1008


<210>  21
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Borrelia garinii HtrA amino acid sequence without signal peptide 
       and without the PDZ2 domain

<400>  21

Glu Glu Lys Asp Asn Thr Val Gln Ala Leu Gln Asp Ser Phe Arg Glu 
1               5                   10                  15      


Val Ser Lys Lys Ile Leu Ser Ser Ser Val Glu Val His Ala Thr Gly 
            20                  25                  30          


Val Ile Lys Gln Ser Phe Pro Ile Pro Phe Phe Phe Phe Asp Met Pro 
        35                  40                  45              


Glu Phe Asp Ser Glu Arg Lys Ser Asn Trp Ala Gly Ser Gly Val Ile 
    50                  55                  60                  


Ile Gly Arg Asp Ser Gln Lys Lys Ser Leu Phe Tyr Val Val Thr Asn 
65                  70                  75                  80  


Ser His Val Val Asp Lys Ala Thr Glu Leu Glu Val Val Ser Tyr Asp 
                85                  90                  95      


Lys Lys Lys His Lys Ala Lys Leu Ile Gly Lys Asp Glu Lys Lys Asp 
            100                 105                 110         


Ile Ala Leu Ile Ser Phe Glu Ser Asp Asp Ala Thr Ile Lys Val Ala 
        115                 120                 125             


Asp Leu Gly Asp Ser Asp Lys Leu Glu Ile Gly Asp Trp Val Met Ala 
    130                 135                 140                 


Val Gly Ser Pro Phe Gln Phe Ser Phe Thr Val Thr Ala Gly Ile Val 
145                 150                 155                 160 


Ser Gly Leu Gln Arg Ser Ala Asn Pro Asn Leu Gln Ser Arg Asn Leu 
                165                 170                 175     


Phe Ile Gln Thr Asp Ala Ala Ile Asn Arg Gly Asn Ser Gly Gly Pro 
            180                 185                 190         


Leu Val Asn Ile Lys Gly Glu Val Ile Gly Ile Asn Ala Trp Ile Ala 
        195                 200                 205             


Ser Asn Ser Gly Gly Asn Ile Gly Leu Gly Phe Ala Ile Pro Val Asn 
    210                 215                 220                 


Asn Ile Lys Ser Thr Val Asp Phe Phe Leu Lys Gly Lys Lys Ile Glu 
225                 230                 235                 240 


Ser Ala Trp Leu Gly Ile Ser Phe Tyr Pro Leu Lys Thr Arg Asp Ser 
                245                 250                 255     


Glu Val Leu Lys Ser Leu Gly Val Glu Gly Lys Asp Val Ser Ala Ala 
            260                 265                 270         


Ile Ile Ala Ser Leu Tyr Pro Gly Ser Pro Ala Val Lys Ser Gly Leu 
        275                 280                 285             


Lys Ala Gly Asp Ile Ile Val Lys Val Asn Gly Val Ser Met Ser Val 
    290                 295                 300                 


Phe Gln Asp Val Thr Ser Tyr Ile Ser Asp Phe Tyr Ala Gly Glu Lys 
305                 310                 315                 320 


Val Asn Val Glu Ile Leu Arg Gly Asn Val Lys Lys Asn Ile Glu Ile 
                325                 330                 335     


<210>  22
<211>  1008
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence encoding Borrelia garinii HtrA without the 
       signal peptide and without the PDZ2 domain

<400>  22
aatctcaata ttttttttga cattacctct taaaatttct acatttactt tctcaccagc       60

ataaaaatcg ctaatatatg atgtaacatc ttgaaaaaca ctcatagaaa ccccattaac      120

cttaacaata atatcgcctg ctttaagccc tgacttaacg gcaggtgaac ctggataaag      180

agaggcaata attgcagctg aaacatcctt accttcaact cctaagcttt ttagtacttc      240

agaatctctt gtctttaaag gataaaaaga aattccaagc catgctgatt caattttttt      300

acctttaaga aaaaaatcta cagtactttt aatattatta acaggaattg caaaacctaa      360

cccaatattt cctccagaat ttgaagctat ccaagcatta attccaataa cttcaccttt      420

tatatttaca agaggaccgc ctgaattacc tctgttgatt gcagcatcag tttgaataaa      480

taaattcctt gattgtaaat taggatttgc agagcgttgt aatccactta caatacctgc      540

tgtaactgta aaactaaatt gaaaaggact acctactgcc ataacccaat cacctatttc      600

aagcttatca ctatctccaa gatcagctac tttaatagtt gcatcatcac tttcaaagct      660

aataagagca atatcttttt tttcatcttt gccaattaac ttagccttgt gctttttttt      720

atcataagac acaacttcaa gttcagttgc cttatctact acatgactat ttgtaaccac      780

ataaaataat gatttttttt gagaatccct accaattatt actccagacc ctgcccaatt      840

gctttttctc tcagaatcaa attctggcat atcaaaaaag aaaaatggaa taggaaaact      900

ctgtttaatt accccggttg catgaacttc tacggacgat gataaaattt tcttggaaac      960

ttccctaaaa gaatcttgta aggcttgtac tgtattgtct ttttcttc                  1008


<210>  23
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of Borrelia afzelii HtrA without the signal 
       peptide and without the PDZ2 domain

<400>  23

Glu Glu Lys Gly Asn Thr Val Gln Thr Leu Gln Asp Ser Phe Arg Glu 
1               5                   10                  15      


Val Ser Lys Lys Ile Leu Pro Ser Ser Val Glu Val His Ala Thr Gly 
            20                  25                  30          


Val Ile Lys Gln Ser Phe Pro Ile Pro Phe Phe Phe Phe Asp Met Pro 
        35                  40                  45              


Glu Phe Asp Ser Glu Arg Lys Ser Asn Trp Ala Gly Ser Gly Val Ile 
    50                  55                  60                  


Ile Gly Arg Asp Ser Lys Asn Lys Ser Leu Phe Tyr Val Val Thr Asn 
65                  70                  75                  80  


Ser His Val Val Asp Lys Ala Thr Glu Leu Glu Val Val Ser Tyr Asp 
                85                  90                  95      


Lys Lys Lys His Lys Ala Lys Leu Ile Gly Lys Asp Glu Lys Lys Asp 
            100                 105                 110         


Ile Ala Leu Ile Ser Phe Glu Ser Asp Asp Ala Thr Ile Lys Val Ala 
        115                 120                 125             


Asp Leu Gly Asp Ser Asp Lys Leu Glu Ile Gly Asp Trp Val Met Ala 
    130                 135                 140                 


Val Gly Ser Pro Phe Gln Phe Ser Phe Thr Val Thr Ala Gly Ile Val 
145                 150                 155                 160 


Ser Gly Leu Gln Arg Ser Ala Asn Pro Asn Leu Gln Ser Arg Asn Leu 
                165                 170                 175     


Phe Ile Gln Thr Asp Ala Ala Ile Asn Arg Gly Asn Ser Gly Gly Pro 
            180                 185                 190         


Leu Val Asn Thr Lys Gly Glu Val Ile Gly Ile Asn Ala Trp Ile Ala 
        195                 200                 205             


Ser Asn Ser Gly Gly Asn Ile Gly Leu Gly Phe Ala Ile Pro Val Asn 
    210                 215                 220                 


Asn Ile Lys Ser Thr Val Asp Phe Phe Leu Lys Gly Lys Lys Ile Glu 
225                 230                 235                 240 


Ser Ala Trp Leu Gly Ile Ser Phe Tyr Pro Leu Lys Thr Arg Asp Pro 
                245                 250                 255     


Glu Val Leu Lys Ser Leu Gly Val Glu Gly Asp Asp Val Pro Ala Ala 
            260                 265                 270         


Ile Ile Ala Ser Leu Tyr Pro Gly Ser Pro Ala Ile Lys Ser Gly Leu 
        275                 280                 285             


Arg Ala Gly Asp Ile Ile Val Lys Val Asn Gly Val Pro Met Ser Val 
    290                 295                 300                 


Phe Gln Asp Val Thr Ser Tyr Ile Ser Asp Phe Tyr Ala Gly Glu Lys 
305                 310                 315                 320 


Ile Asn Val Glu Ile Leu Arg Gly Asn Val Lys Lys Asn Ile Glu Ile 
                325                 330                 335     


<210>  24
<211>  1008
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence encoding Borrelia afzelii HtrA without the 
       signal peptide and without the PDZ2 domain

<400>  24
aatctcaata ttctttttaa cattacctct taaaatttct acattgattt tctcaccagc       60

ataaaaatcg ctaatatatg atgtaacgtc ttgaaaaaca ctcatgggaa ctccattaac      120

cttcacaata atgtctcccg ctctaagccc tgacttaata gcaggtgaac ctggataaag      180

agaagcaata attgcagctg gaacatcatc accttcaacc cccaagcttt ttagcacttc      240

aggatctctt gtctttaatg ggtaaaaaga aattccaagc catgctgatt caattttttt      300

acctttaagg aaaaaatcta cggtactttt aatattgtta acaggaattg caaaacctaa      360

cccaatattt ccaccagaat ttgaagctat ccaagcatta atcccaataa cttcaccttt      420

tgtatttaca agaggtccac ctgaattacc tctattgatt gcagcatcag tttgaataaa      480

taaatttctt gattgtaaat taggatttgc agaacgttgc aatccactta caatacctgc      540

tgtaactgta aaactaaatt gaaaagggct acctaccgcc ataacccaat cacctatttc      600

aagcttatca ctatccccaa gatcagccac tttaatagtt gcatcatcac tttcaaagct      660

aataagcgca atatcctttt tttcatcttt gccaattaac ttagccttat gctttttctt      720

atcataagat acaacttcaa gttcagttgc cttatctact acatgactat tggtaactac      780

ataaaataat gatttatttt tggaatctct accaattatt actccagacc ctgcccaatt      840

gctttttctc tcagaatcaa attctggcat atcaaaaaag aaaaatggaa taggaaaact      900

ctgcttaatt acccctgttg catgaacttc tacagatgat ggtaaaattt tcttggaaac      960

ttctctaaaa gagtcttgca aggtttgtac tgtattaccc ttttcttc                  1008


<210>  25
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer for BbHtrA

<400>  25
ctttaagaag gagatataca tatggaagaa aaagataaca ccgtg                       45


<210>  26
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer for BbHtrA

<400>  26
atacagctgt gcggccgcaa gctttcatta gtgatggtga tggtgatgaa                  50


<210>  27
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA peptide

<400>  27

Val Ser Ala Ala Ile Ile Ala Ser Leu Tyr Pro Gly Ser Pro Ala Val 
1               5                   10                  15      


Lys Ser Gly 
            


<210>  28
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  neoepitope

<400>  28

Asp Ile Pro Glu Asn 
1               5   


<210>  29
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  neoepitope

<400>  29

Ala Arg Gly Ser 
1               


<210>  30
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  neoepitope

<400>  30

Asn Ile Thr Glu Gly Glu 
1               5       


<210>  31
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleavage site

<400>  31

Val Gln Thr Val 
1               


<210>  32
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino terminal peptide of recombinant aggrecan

<400>  32

Val Glu Thr Ser Asp His Asp Asn Ser Leu Ser 
1               5                   10      


<210>  33
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bovine decorin peptide

<400>  33

Gly Leu Glu Lys Val Pro Lys Asp Leu Pro Pro Asp Thr Ala Leu Leu 
1               5                   10                  15      


Asp Leu Gln Asn Asn Lys Ile Thr Glu Ile 
            20                  25      


<210>  34
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bovine decorin peptide

<400>  34

Val Val Glu Leu Gly Thr Asn Pro Leu Lys Ser 
1               5                   10      


<210>  35
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bovine decorin peptide

<400>  35

Val Val Glu Leu Gly Thr Asn Pro Leu Lys Ser Ser Gly Ile Glu Asn 
1               5                   10                  15      


Gly Ala Phe Gln Gly Met Lys Lys Leu Ser 
            20                  25      


<210>  36
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bovine decorin peptide

<400>  36

Val Val Glu Leu Gly Thr Asn Pro Leu Lys Ser Ser Gly Ile Glu Asn 
1               5                   10                  15      


Gly Ala Phe Gln Gly Met Lys Lys Leu Ser Tyr Ile Arg Ile 
            20                  25                  30  


<210>  37
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bovine decorin peptide

<400>  37

Val Val Glu Leu Gly Thr Asn Pro Leu Lys Ser Ser Gly Ile Glu Asn 
1               5                   10                  15      


Gly Ala Phe Gln Gly Met Lys Lys Leu 
            20                  25  


<210>  38
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bovine biglycan peptide

<400>  38

Gly Leu Pro Asp Leu Lys Leu Leu 
1               5               


<210>  39
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bovine biglycan peptide

<400>  39

Gly Leu Pro Asp Leu Lys Leu Leu Gln Val 
1               5                   10  


<210>  40
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bovine biglycan peptide

<400>  40

Gly Leu Pro Asp Leu Lys Leu Leu Gln Val Val 
1               5                   10      


<210>  41
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bovine aggrecan peptide

<400>  41

Thr Leu Pro Asn Tyr Pro Ala Ile Pro Ser Asp Ala 
1               5                   10          


<210>  42
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bovine aggrecan peptide

<400>  42

Thr Leu Pro Asn Tyr Pro Ala Ile Pro Ser Asp Ala Thr Leu Glu Ile 
1               5                   10                  15      


<210>  43
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bovine aggrecan peptide

<400>  43

Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr Pro Ile 
1               5                   10          


<210>  44
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bovine fibromodulin peptide

<400>  44

Tyr Leu Gln Gly Asn Arg Ile Asn Glu Phe Ser Ile 
1               5                   10          


<210>  45
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bovine fibromodulin peptide

<400>  45

Val Val Asp Val Met Asn Phe Ser Lys Leu Gln Val 
1               5                   10          


<210>  46
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bovine fibromodulin peptide

<400>  46

Val Asp Val Met Asn Phe Ser Lys Leu Gln Val 
1               5                   10      


<210>  47
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bovine COMP peptide

<400>  47

Val Met Trp Lys Gln Met Glu Gln Thr 
1               5                   


<210>  48
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bovine COMP peptide

<400>  48

Met Trp Lys Gln Met Glu Gln Thr Tyr Trp Gln Ala 
1               5                   10          


<210>  49
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bovine COMP peptide

<400>  49

Met Trp Lys Gln Met Glu Gln Thr Tyr Trp Gln Ala Asn Pro Phe Arg 
1               5                   10                  15      


Ala 
    


<210>  50
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bovine COMP peptide

<400>  50

Trp His Thr Gly Asp Thr Ala Ser Gln Val 
1               5                   10  


<210>  51
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bovine COMP peptide

<400>  51

Trp His Thr Gly Asp Thr Ala Ser Gln Val Arg Leu 
1               5                   10          


<210>  52
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  52

Gly Leu Asp Lys Val Pro Lys Asp Leu Pro Pro Asp Thr Thr Leu Leu 
1               5                   10                  15      


Asp Leu Gln Asn Asn Lys Ile Thr Glu Ile 
            20                  25      


<210>  53
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  53

Val Ile Glu Leu Gly Thr Asn Pro Leu Lys Ser 
1               5                   10      


<210>  54
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  54

Val Ile Glu Leu Gly Thr Asn Pro Leu Lys Ser Ser Gly Ile Glu Asn 
1               5                   10                  15      


Gly Ala Phe Gln Gly Met Lys Lys Leu Ser 
            20                  25      


<210>  55
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  55

Val Ile Glu Leu Gly Thr Asn Pro Leu Lys Ser Ser Gly Ile Glu Asn 
1               5                   10                  15      


Gly Ala Phe Gln Gly Met Lys Lys Leu Ser Tyr Ile Arg Ile 
            20                  25                  30  


<210>  56
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  56

Gly Leu Pro Asp Leu Lys Leu Leu 
1               5               


<210>  57
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  57

Gly Leu Pro Asp Leu Lys Leu Leu Gln Val 
1               5                   10  


<210>  58
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  58

Gly Leu Pro Asp Leu Lys Leu Leu Gln Val Val 
1               5                   10      


<210>  59
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  59

Ser Leu Pro Asn Tyr Pro Ala Ile Pro Ser Asp Ala 
1               5                   10          


<210>  60
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  60

Ser Leu Pro Asn Tyr Pro Ala Ile Pro Ser Asp Ala Thr Leu Glu Val 
1               5                   10                  15      


<210>  61
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  61

Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr Pro Ile 
1               5                   10          


<210>  62
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  62

Tyr Leu Gln Gly Asn Arg Ile Asn Glu Phe Ser Ile 
1               5                   10          


<210>  63
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  63

Val Val Asp Val Val Asn Phe Ser Lys Leu Gln Val 
1               5                   10          


<210>  64
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  64

Val Asp Val Val Asn Phe Ser Lys Leu Gln Val 
1               5                   10      


<210>  65
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  65

Val Met Trp Lys Gln Met Glu Gln Thr 
1               5                   


<210>  66
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  66

Met Trp Lys Gln Met Glu Gln Thr Tyr Trp Gln Ala 
1               5                   10          


<210>  67
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  67

Met Trp Lys Gln Met Glu Gln Thr Tyr Trp Gln Ala Asn Pro Phe Arg 
1               5                   10                  15      


Ala 
    


<210>  68
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  68

Trp His Thr Gly Asp Thr Glu Ser Gln Val 
1               5                   10  


<210>  69
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  69

Trp His Thr Gly Asp Thr Glu Ser Gln Val Arg Leu 
1               5                   10          


<210>  70
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  70

Ala Phe Gln Thr Val Val Leu Asp 
1               5               


<210>  71
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  71

Ala Ile Glu Leu Glu Asp Leu Leu 
1               5               


<210>  72
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  72

Ala Lys Leu Thr Gly Ile Pro Lys 
1               5               


<210>  73
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  73

Ala Val Lys Ser Ser Thr Gly Pro 
1               5               


<210>  74
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  74

Cys Ile Glu Met Gly Gly Asn Pro 
1               5               


<210>  75
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  75

Cys Ser Asp Leu Gly Leu Glu Lys 
1               5               


<210>  76
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  76

Cys Val Tyr Val Arg Ala Ala Val 
1               5               


<210>  77
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  77

Asp Ile Lys Ala Gln Leu Asn Leu 
1               5               


<210>  78
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  78

Asp Thr Asn Ile Thr Thr Ile Pro 
1               5               


<210>  79
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  79

Phe Cys Thr Val Val Asp Val Met 
1               5               


<210>  80
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  80

Phe Glu Pro Gly Ala Phe Asp Gly 
1               5               


<210>  81
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  81

Phe Gln Thr Val Val Leu Asp Pro 
1               5               


<210>  82
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  82

Phe Arg Ala Val Ala Glu Pro Gly 
1               5               


<210>  83
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  83

Phe Arg Cys Val Thr Asp Arg Leu 
1               5               


<210>  84
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  84

Phe Tyr Val Val Met Trp Lys Gln 
1               5               


<210>  85
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  85

Gly Ile Ser Leu Phe Asn Asn Pro 
1               5               


<210>  86
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  86

Gly Leu Lys Leu Asn Tyr Leu Arg 
1               5               


<210>  87
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  87

Gly Leu Pro Ser Ala Leu Glu Gln 
1               5               


<210>  88
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  88

Gly Val Val Val Asp Tyr Ile Asp 
1               5               


<210>  89
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  89

His Glu Lys Ala Phe Ser Pro Leu 
1               5               


<210>  90
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  90

His Leu Tyr Ala Leu Val Leu Val 
1               5               


<210>  91
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  91

His Asn Asn Val Phe Ser Val Pro 
1               5               


<210>  92
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  92

Ile Glu Met Gly Gly Asn Pro Leu 
1               5               


<210>  93
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  93

Ile His Gln Leu Tyr Leu Asp Ser 
1               5               


<210>  94
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  94

Ile Ile Ala Ser Leu Tyr Pro Gly 
1               5               


<210>  95
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  95

Ile Met Lys Val Asn Gly Val Ser 
1               5               


<210>  96
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  96

Ile Pro Phe Phe Phe Phe Asp Met 
1               5               


<210>  97
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  97

Ile Gln Glu Val Gly Ser Ser Met 
1               5               


<210>  98
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  98

Ile Ser Glu Ala Lys Leu Thr Gly 
1               5               


<210>  99
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  99

Ile Ser Lys Ile Ser Pro Gly Ala 
1               5               


<210>  100
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  100

Ile Ser Leu Phe Asn Asn Pro Val 
1               5               


<210>  101
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  101

Ile Ser Pro Gly Ala Phe Ala Pro 
1               5               


<210>  102
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  102

Ile Val Gln Thr Met Asn Ser Asp 
1               5               


<210>  103
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  103

Lys Asp Lys Thr Ser Tyr Arg Trp 
1               5               


<210>  104
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  104

Lys Glu Leu Ser Ser Ser Lys Met 
1               5               


<210>  105
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  105

Lys Gly Val Val Val Asp Tyr Ile 
1               5               


<210>  106
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  106

Lys Ile Gln Ala Ile Glu Leu Glu 
1               5               


<210>  107
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  107

Lys Leu Gln Val Leu Arg Leu Asp 
1               5               


<210>  108
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  108

Lys Leu Tyr Ile Ser Lys Asn His 
1               5               


<210>  109
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  109

Lys Val Asp Ala Ala Ser Leu Lys 
1               5               


<210>  110
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  110

Leu Glu Asn Leu Tyr Leu Gln Gly 
1               5               


<210>  111
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  111

Leu Glu Asn Ser Gly Phe Glu Pro 
1               5               


<210>  112
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  112

Leu Ile Leu Ile Asn Asn Lys Ile 
1               5               


<210>  113
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  113

Leu Lys Ala Val Lys Ser Ser Thr 
1               5               


<210>  114
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  114

Leu Pro Pro Ser Leu Thr Glu Leu 
1               5               


<210>  115
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  115

Leu Gln Asn Ser Ala Ile Ile Ala 
1               5               


<210>  116
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  116

Leu Arg Asn Ala Leu Trp His Thr 
1               5               


<210>  117
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  117

Met Cys Ser Ala Gly Trp Leu Ala 
1               5               


<210>  118
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  118

Met Glu Gln Thr Tyr Trp Gln Ala 
1               5               


<210>  119
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  119

Met Lys Lys Leu Ser Tyr Ile Arg 
1               5               


<210>  120
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  120

Met Asn Cys Ile Glu Met Gly Gly 
1               5               


<210>  121
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  121

Asn Gly Ile Ser Leu Phe Asn Asn 
1               5               


<210>  122
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  122

Asn His Leu Val Glu Ile Pro Pro 
1               5               


<210>  123
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  123

Asn Lys Leu Ser Arg Val Pro Ala 
1               5               


<210>  124
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  124

Asn Leu Pro Ser Ser Leu Val Glu 
1               5               


<210>  125
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  125

Asn Asn Lys Ile Ser Lys Ile Ser 
1               5               


<210>  126
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  126

Asn Asn Lys Leu Ser Arg Val Pro 
1               5               


<210>  127
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  127

Asn Gln Met Ile Val Val Glu Leu 
1               5               


<210>  128
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  128

Asn Gln Thr Gly Leu Leu Asp Pro 
1               5               


<210>  129
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  129

Asn Arg Asn Leu Lys Tyr Leu Pro 
1               5               


<210>  130
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  130

Asn Trp Val Val Leu Asn Gln Gly 
1               5               


<210>  131
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  131

Pro Asp Thr Ala Leu Leu Asp Leu 
1               5               


<210>  132
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  132

Pro Asp Thr Thr Leu Leu Asp Leu 
1               5               


<210>  133
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  133

Pro Phe Arg Ala Val Ala Glu Pro 
1               5               


<210>  134
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  134

Pro Asn Trp Val Val Leu Asn Gln 
1               5               


<210>  135
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  135

Pro Ser Arg Met Lys Tyr Val Tyr 
1               5               


<210>  136
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  136

Pro Val Ser Thr Asn Leu Glu Asn 
1               5               


<210>  137
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  137

Gln Cys Asp Ala Gly Trp Leu Ala 
1               5               


<210>  138
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  138

Gln Asp Lys Val Thr Leu Pro Asn 
1               5               


<210>  139
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  139

Gln Leu Lys Ala Val Lys Ser Ser 
1               5               


<210>  140
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  140

Gln Thr Val Val Leu Asp Pro Glu 
1               5               


<210>  141
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  141

Arg Asn Ala Leu Trp His Thr Gly 
1               5               


<210>  142
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  142

Arg Asn Trp Ile Lys Gly Val Val 
1               5               


<210>  143
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  143

Arg Ser Leu Ile Leu Leu Asp Leu 
1               5               


<210>  144
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  144

Arg Val Pro Ala Gly Leu Pro Asp 
1               5               


<210>  145
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  145

Ser Phe Cys Thr Val Val Asp Val 
1               5               


<210>  146
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  146

Ser Phe Tyr Val Val Met Trp Lys 
1               5               


<210>  147
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  147

Ser Lys Asn His Leu Val Glu Ile 
1               5               


<210>  148
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  148

Ser Lys Ser Val Ser Asn Leu Arg 
1               5               


<210>  149
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  149

Ser Leu Ser Val Ser Ile Pro Glu 
1               5               


<210>  150
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  150

Ser Pro Gly Ala Phe Ala Pro Leu 
1               5               


<210>  151
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  151

Thr Lys Lys Ala Ser Tyr Ser Gly 
1               5               


<210>  152
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  152

Thr Ser Tyr Ile Ser Asp Phe Tyr 
1               5               


<210>  153
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  153

Val Phe Tyr Ala Thr Ser Pro Glu 
1               5               


<210>  154
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  154

Val Lys Arg Ala Tyr Tyr Asn Gly 
1               5               


<210>  155
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  155

Val Val Asp Val Met Asn Phe Ser 
1               5               


<210>  156
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  156

Val Val Glu Leu Gly Thr Asn Pro 
1               5               


<210>  157
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  157

Tyr Ile Arg Val Arg Phe Tyr Glu 
1               5               


<210>  158
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  158

Tyr Leu Arg Ile Ser Glu Ala Lys 
1               5               


<210>  159
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  159

Tyr Asn Gly Ile Ser Leu Phe Asn 
1               5               


<210>  160
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  160

Tyr Ser Gly Val Ser Leu Phe Ser 
1               5               


<210>  161
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  161

Tyr Val Arg Ala Ala Val Gln Leu 
1               5               


<210>  162
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BbHtrA protease cleavage site

<400>  162

Tyr Trp Gln Ala Asn Pro Phe Arg 
1               5               


<210>  163
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  163

Val Ser Ile Pro Gln Pro Ser Pro Leu Arg Val Leu Leu Gly Thr Ser 
1               5                   10                  15      


Leu Thr Ile Pro Cys Tyr Phe Ile Asp Pro Met His Pro Val Thr Thr 
            20                  25                  30          


Ala Pro 
        


<210>  164
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  164

Ser Ile Pro Gln Pro Ser Pro Leu Arg Val Leu Leu Gly Thr Ser Leu 
1               5                   10                  15      


Thr Ile Pro Cys Tyr Phe Ile Asp Pro Met His Pro Val Thr Thr Ala 
            20                  25                  30          


Pro Ser 
        


<210>  165
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  165

Leu Leu Val Ala Thr Glu Gly Arg Val Arg Val Asn Ser Ala Tyr Gln 
1               5                   10                  15      


Asp Lys Val Ser Leu Pro Asn Tyr Pro Ala Ile Pro Ser Asp Ala Thr 
            20                  25                  30          


Leu Glu 
        


<210>  166
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  166

Ser Leu Pro Asn Tyr Pro Ala Ile Pro Ser Asp Ala Thr Leu Glu Val 
1               5                   10                  15      


Gln Ser Leu Arg Ser Asn Asp Ser Gly Val Tyr Arg Cys Glu Val Met 
            20                  25                  30          


His Gly 
        


<210>  167
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  167

Thr Leu Glu Val Gln Ser Leu Arg Ser Asn Asp Ser Gly Val Tyr Arg 
1               5                   10                  15      


Cys Glu Val Met His Gly Ile Glu Asp Ser Glu Ala Thr Leu Glu Val 
            20                  25                  30          


Val Val 
        


<210>  168
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  168

Ala Tyr Glu Asp Gly Phe His Gln Cys Asp Ala Gly Trp Leu Ala Asp 
1               5                   10                  15      


Gln Thr Val Arg Tyr Pro Ile His Thr Pro Arg Glu Gly Cys Tyr Gly 
            20                  25                  30          


Asp Lys 
        


<210>  169
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  169

Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr Pro Ile His Thr Pro Arg 
1               5                   10                  15      


Glu Gly Cys Tyr Gly Asp Lys Asp Glu Phe Pro Gly Val Arg Thr Tyr 
            20                  25                  30          


Gly Ile 
        


<210>  170
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  170

Thr Ser Pro Glu Lys Phe Thr Phe Gln Glu Ala Ala Asn Glu Cys Arg 
1               5                   10                  15      


Arg Leu Gly Ala Arg Leu Ala Thr Thr Gly His Val Tyr Leu Ala Trp 
            20                  25                  30          


Gln Ala 
        


<210>  171
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  171

Gly Trp Leu Ala Asp Arg Ser Val Arg Tyr Pro Ile Ser Lys Ala Arg 
1               5                   10                  15      


Pro Asn Cys Gly Gly Asn Leu Leu Gly Val Arg Thr Val Tyr Val His 
            20                  25                  30          


Ala Asn 
        


<210>  172
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  172

Gly Tyr Pro Asp Pro Ser Ser Arg Tyr Asp Ala Ile Cys Tyr Thr Gly 
1               5                   10                  15      


Glu Asp Phe Val Asp Ile Pro Glu Asn Phe Phe Gly Val Gly Gly Glu 
            20                  25                  30          


Glu Asp 
        


<210>  173
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  173

Ser Pro Ser Pro Leu Glu Pro Glu Glu Pro Phe Thr Phe Ala Pro Glu 
1               5                   10                  15      


Ile Gly Ala Thr Ala Phe Ala Glu Val Glu Asn Glu Thr Gly Glu Ala 
            20                  25                  30          


Thr Arg 
        


<210>  174
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  174

Ala Tyr Glu Ala Gly Tyr Glu Gln Cys Asp Ala Gly Trp Leu Arg Asp 
1               5                   10                  15      


Gln Thr Val Arg Tyr Pro Ile Val Ser Pro Arg Thr Pro Cys Val Gly 
            20                  25                  30          


Asp Lys 
        


<210>  175
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  175

Gly Trp Leu Ala Asp Gly Ser Leu Arg Tyr Pro Ile Val Thr Pro Arg 
1               5                   10                  15      


Pro Ala Cys Gly Gly Asp Lys Pro Gly Val Arg Thr Val Tyr Leu Tyr 
            20                  25                  30          


Pro Asn 
        


<210>  176
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  176

Gly Leu Pro Asp Pro Leu Ser Arg His His Ala Phe Cys Phe Arg Gly 
1               5                   10                  15      


Ile Ser Ala Val Pro Ser Pro Gly Glu Glu Glu Gly Gly Thr Pro Thr 
            20                  25                  30          


Ser Pro 
        


<210>  177
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  177

Ser Gly Leu Pro Ser Gly Asp Leu Asp Ser Ser Gly Leu Thr Ser Thr 
1               5                   10                  15      


Val Gly Ser Gly Leu Thr Val Glu Ser Gly Leu Pro Ser Gly Asp Glu 
            20                  25                  30          


Glu Arg 
        


<210>  178
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  178

Gly Leu Pro Ser Gly Asp Glu Glu Arg Ile Glu Trp Pro Ser Thr Pro 
1               5                   10                  15      


Thr Val Gly Glu Leu Pro Ser Gly Ala Glu Ile Leu Glu Gly Ser Ala 
            20                  25                  30          


Ser Gly 
        


<210>  179
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  179

Gly Asp Glu Glu Arg Ile Glu Trp Pro Ser Thr Pro Thr Val Gly Glu 
1               5                   10                  15      


Leu Pro Ser Gly Ala Glu Ile Leu Glu Gly Ser Ala Ser Gly Val Gly 
            20                  25                  30          


Asp Leu 
        


<210>  180
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  180

Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Ser Ala Ser Gly Val Gly 
1               5                   10                  15      


Asp Leu Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Thr Ala Pro 
            20                  25                  30          


Gly Val 
        


<210>  181
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  181

Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Ser Ala Ser Gly Val Gly 
1               5                   10                  15      


Asp Leu Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Thr Ala Pro 
            20                  25                  30          


Gly Val 
        


<210>  182
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  182

Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Thr Ala Pro Gly Val 
1               5                   10                  15      


Asp Glu Ile Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Thr Ala 
            20                  25                  30          


Pro Gly 
        


<210>  183
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  183

Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Thr Ala Pro Gly Val 
1               5                   10                  15      


Asp Glu Ile Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Thr Ala 
            20                  25                  30          


Pro Gly 
        


<210>  184
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  184

Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Ser Ala Ser Gly Val Gly 
1               5                   10                  15      


Asp Leu Ser Gly Leu Pro Ser Gly Glu Val Leu Glu Thr Thr Ala Pro 
            20                  25                  30          


Gly Val 
        


<210>  185
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  185

Ser Val Ser Gly Val Glu Asp Ile Ser Gly Leu Pro Ser Gly Glu Val 
1               5                   10                  15      


Val Glu Thr Ser Ala Ser Gly Ile Glu Asp Val Ser Glu Leu Pro Ser 
            20                  25                  30          


Gly Glu 
        


<210>  186
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  186

Gly Val Glu Asp Ile Ser Gly Leu Pro Ser Gly Glu Val Val Glu Thr 
1               5                   10                  15      


Ser Ala Ser Gly Ile Glu Asp Val Ser Glu Leu Pro Ser Gly Glu Gly 
            20                  25                  30          


Leu Glu 
        


<210>  187
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  187

Ser Glu Leu Pro Ser Gly Glu Gly Leu Glu Thr Ser Ala Ser Gly Val 
1               5                   10                  15      


Glu Asp Leu Ser Arg Leu Pro Ser Gly Glu Glu Val Leu Glu Ile Ser 
            20                  25                  30          


Ala Ser 
        


<210>  188
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  188

Gly Thr Asp Leu Ser Gly Leu Pro Ser Gly Arg Glu Gly Leu Glu Thr 
1               5                   10                  15      


Ser Ala Ser Gly Ala Glu Asp Leu Ser Gly Leu Pro Ser Gly Lys Glu 
            20                  25                  30          


Asp Leu 
        


<210>  189
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  189

Gly Leu Pro Ser Gly Arg Glu Gly Leu Glu Thr Ser Ala Ser Gly Ala 
1               5                   10                  15      


Glu Asp Leu Ser Gly Leu Pro Ser Gly Lys Glu Asp Leu Val Gly Ser 
            20                  25                  30          


Ala Ser 
        


<210>  190
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  190

Gly Thr Leu Gly Ser Gly Gln Ala Pro Glu Thr Ser Gly Leu Pro Ser 
1               5                   10                  15      


Gly Phe Ser Gly Glu Tyr Ser Gly Val Asp Leu Gly Ser Gly Pro Pro 
            20                  25                  30          


Ser Gly 
        


<210>  191
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  191

Gly Leu Pro Ser Gly Phe Ser Gly Glu Tyr Ser Gly Val Asp Leu Gly 
1               5                   10                  15      


Ser Gly Pro Pro Ser Gly Leu Pro Asp Phe Ser Gly Leu Pro Ser Gly 
            20                  25                  30          


Phe Pro 
        


<210>  192
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  192

Gly Leu Pro Asp Phe Ser Gly Leu Pro Ser Gly Phe Pro Thr Val Ser 
1               5                   10                  15      


Leu Val Asp Ser Thr Leu Val Glu Val Val Thr Ala Ser Thr Ala Ser 
            20                  25                  30          


Glu Leu 
        


<210>  193
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  193

Ser Leu Val Asp Ser Thr Leu Val Glu Val Val Thr Ala Ser Thr Ala 
1               5                   10                  15      


Ser Glu Leu Glu Gly Arg Gly Thr Ile Gly Ile Ser Gly Ala Gly Glu 
            20                  25                  30          


Ile Ser 
        


<210>  194
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  194

Thr Leu Val Glu Val Val Thr Ala Ser Thr Ala Ser Glu Leu Glu Gly 
1               5                   10                  15      


Arg Gly Thr Ile Gly Ile Ser Gly Ala Gly Glu Ile Ser Gly Leu Pro 
            20                  25                  30          


Ser Ser 
        


<210>  195
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  195

Ser Glu Leu Glu Gly Arg Gly Thr Ile Gly Ile Ser Gly Ala Gly Glu 
1               5                   10                  15      


Ile Ser Gly Leu Pro Ser Ser Glu Leu Asp Ile Ser Gly Arg Ala Ser 
            20                  25                  30          


Gly Leu 
        


<210>  196
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  196

Gly Leu Pro Ser Gly Thr Glu Leu Ser Gly Gln Ala Ser Gly Ser Pro 
1               5                   10                  15      


Asp Val Ser Gly Glu Ile Pro Gly Leu Phe Gly Val Ser Gly Gln Pro 
            20                  25                  30          


Ser Gly 
        


<210>  197
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  197

Gly Thr Glu Leu Ser Gly Gln Ala Ser Gly Ser Pro Asp Val Ser Gly 
1               5                   10                  15      


Glu Ile Pro Gly Leu Phe Gly Val Ser Gly Gln Pro Ser Gly Phe Pro 
            20                  25                  30          


Asp Thr 
        


<210>  198
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  198

Gly Leu Pro Gly Phe Ser Gly Ala Thr Ser Gly Val Pro Asp Leu Val 
1               5                   10                  15      


Ser Gly Thr Thr Ser Gly Ser Gly Glu Ser Ser Gly Ile Thr Phe Val 
            20                  25                  30          


Asp Thr 
        


<210>  199
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  199

Ser Leu Val Glu Val Ala Pro Thr Thr Phe Lys Glu Glu Glu Gly Leu 
1               5                   10                  15      


Gly Ser Val Glu Leu Ser Gly Leu Pro Ser Gly Glu Ala Asp Leu Ser 
            20                  25                  30          


Gly Lys 
        


<210>  200
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  200

Ser Gly Leu Pro Ser Gly Glu Ala Asp Leu Ser Gly Lys Ser Gly Met 
1               5                   10                  15      


Val Asp Val Ser Gly Gln Phe Ser Gly Thr Val Asp Ser Ser Gly Phe 
            20                  25                  30          


Thr Ser 
        


<210>  201
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  201

Gly Leu Pro Ser Gly Glu Ala Asp Leu Ser Gly Lys Ser Gly Met Val 
1               5                   10                  15      


Asp Val Ser Gly Gln Phe Ser Gly Thr Val Asp Ser Ser Gly Phe Thr 
            20                  25                  30          


Ser Gln 
        


<210>  202
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  202

Ser Leu Val Asp Ser Thr Leu Val Glu Val Val Thr Ala Ser Thr Ala 
1               5                   10                  15      


Ser Glu Leu Glu Gly Arg Gly Thr Ile Gly Ile Ser Gly Ala Gly Glu 
            20                  25                  30          


Ile Ser 
        


<210>  203
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  203

Gly Leu Ile Glu Pro Ser Gly Glu Pro Pro Gly Thr Pro Tyr Phe Ser 
1               5                   10                  15      


Gly Asp Phe Ala Ser Thr Thr Asn Val Ser Gly Glu Ser Ser Val Ala 
            20                  25                  30          


Met Gly 
        


<210>  204
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  204

Gly Glu Pro Pro Gly Thr Pro Tyr Phe Ser Gly Asp Phe Ala Ser Thr 
1               5                   10                  15      


Thr Asn Val Ser Gly Glu Ser Ser Val Ala Met Gly Thr Ser Gly Glu 
            20                  25                  30          


Ala Ser 
        


<210>  205
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  205

Gly Leu Pro Glu Val Thr Leu Ile Thr Ser Glu Phe Val Glu Gly Val 
1               5                   10                  15      


Thr Glu Pro Thr Ile Ser Gln Glu Leu Gly Gln Arg Pro Pro Val Thr 
            20                  25                  30          


His Thr 
        


<210>  206
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  206

Ser Ser Val Pro Glu Ser Ser Ser Glu Thr Ser Ala Tyr Pro Glu Ala 
1               5                   10                  15      


Gly Phe Gly Ala Ser Ala Ala Pro Glu Ala Ser Arg Glu Asp Ser Gly 
            20                  25                  30          


Ser Pro 
        


<210>  207
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  207

Ser Val Pro Glu Ser Ser Ser Glu Thr Ser Ala Tyr Pro Glu Ala Gly 
1               5                   10                  15      


Phe Gly Ala Ser Ala Ala Pro Glu Ala Ser Arg Glu Asp Ser Gly Ser 
            20                  25                  30          


Pro Asp 
        


<210>  208
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  208

Ala Tyr Pro Glu Ala Gly Phe Gly Ala Ser Ala Ala Pro Glu Ala Ser 
1               5                   10                  15      


Arg Glu Asp Ser Gly Ser Pro Asp Leu Ser Glu Thr Thr Ser Ala Phe 
            20                  25                  30          


His Glu 
        


<210>  209
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  209

Ser Gly Leu Gly Val Ser Gly Ser Thr Leu Thr Phe Gln Glu Gly Glu 
1               5                   10                  15      


Ala Ser Ala Ala Pro Glu Val Ser Gly Glu Ser Thr Thr Thr Ser Asp 
            20                  25                  30          


Val Gly 
        


<210>  210
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  210

Ser Ile Pro Glu Ser Glu Trp Thr Gln Gln Thr Gln Arg Pro Ala Glu 
1               5                   10                  15      


Thr His Leu Glu Ile Glu Ser Ser Ser Leu Leu Tyr Ser Gly Glu Glu 
            20                  25                  30          


Thr His 
        


<210>  211
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  211

Ser Leu Leu Tyr Ser Gly Glu Glu Thr His Thr Val Glu Thr Ala Thr 
1               5                   10                  15      


Ser Pro Thr Asp Ala Ser Ile Pro Ala Ser Pro Glu Trp Lys Arg Glu 
            20                  25                  30          


Ser Glu 
        


<210>  212
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  212

Leu Tyr Ser Gly Glu Glu Thr His Thr Val Glu Thr Ala Thr Ser Pro 
1               5                   10                  15      


Thr Asp Ala Ser Ile Pro Ala Ser Pro Glu Trp Lys Arg Glu Ser Glu 
            20                  25                  30          


Ser Thr 
        


<210>  213
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human aggrecan peptide

<400>  213

Val Thr Pro Glu Glu Gln Glu Phe Val Asn Asn Asn Ala Gln Asp Tyr 
1               5                   10                  15      


Gln Trp Ile Gly Leu Asn Asp Arg Thr Ile Glu Gly Asp Phe Arg Trp 
            20                  25                  30          


Ser Asp 
        


<210>  214
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  214

Val Ser Leu Leu Ala Leu Ser Gln Ala Leu Pro Phe Glu Gln Arg Gly 
1               5                   10                  15      


Phe Trp Asp Phe Thr Leu Asp Asp Gly Pro Phe Met Met Asn Asp Glu 
            20                  25                  30          


Glu Ala 
        


<210>  215
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  215

Leu Leu Ala Leu Ser Gln Ala Leu Pro Phe Glu Gln Arg Gly Phe Trp 
1               5                   10                  15      


Asp Phe Thr Leu Asp Asp Gly Pro Phe Met Met Asn Asp Glu Glu Ala 
            20                  25                  30          


Ser Gly 
        


<210>  216
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  216

Leu Ala Leu Ser Gln Ala Leu Pro Phe Glu Gln Arg Gly Phe Trp Asp 
1               5                   10                  15      


Phe Thr Leu Asp Asp Gly Pro Phe Met Met Asn Asp Glu Glu Ala Ser 
            20                  25                  30          


Gly Ala 
        


<210>  217
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  217

Ala Leu Ser Gln Ala Leu Pro Phe Glu Gln Arg Gly Phe Trp Asp Phe 
1               5                   10                  15      


Thr Leu Asp Asp Gly Pro Phe Met Met Asn Asp Glu Glu Ala Ser Gly 
            20                  25                  30          


Ala Asp 
        


<210>  218
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  218

Leu Ser Gln Ala Leu Pro Phe Glu Gln Arg Gly Phe Trp Asp Phe Thr 
1               5                   10                  15      


Leu Asp Asp Gly Pro Phe Met Met Asn Asp Glu Glu Ala Ser Gly Ala 
            20                  25                  30          


Asp Thr 
        


<210>  219
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  219

Leu Pro Phe Glu Gln Arg Gly Phe Trp Asp Phe Thr Leu Asp Asp Gly 
1               5                   10                  15      


Pro Phe Met Met Asn Asp Glu Glu Ala Ser Gly Ala Asp Thr Ser Gly 
            20                  25                  30          


Val Leu 
        


<210>  220
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  220

Gly Val Leu Asp Pro Asp Ser Val Thr Pro Thr Tyr Ser Ala Met Cys 
1               5                   10                  15      


Pro Phe Gly Cys His Cys His Leu Arg Val Val Gln Cys Ser Asp Leu 
            20                  25                  30          


Gly Leu 
        


<210>  221
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  221

Val Leu Asp Pro Asp Ser Val Thr Pro Thr Tyr Ser Ala Met Cys Pro 
1               5                   10                  15      


Phe Gly Cys His Cys His Leu Arg Val Val Gln Cys Ser Asp Leu Gly 
            20                  25                  30          


Leu Lys 
        


<210>  222
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  222

Leu Asp Pro Asp Ser Val Thr Pro Thr Tyr Ser Ala Met Cys Pro Phe 
1               5                   10                  15      


Gly Cys His Cys His Leu Arg Val Val Gln Cys Ser Asp Leu Gly Leu 
            20                  25                  30          


Lys Ser 
        


<210>  223
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  223

Gly Leu Lys Ser Val Pro Lys Glu Ile Ser Pro Asp Thr Thr Leu Leu 
1               5                   10                  15      


Asp Leu Gln Asn Asn Asp Ile Ser Glu Leu Arg Lys Asp Asp Phe Lys 
            20                  25                  30          


Gly Leu 
        


<210>  224
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  224

Leu Leu Asp Leu Gln Asn Asn Asp Ile Ser Glu Leu Arg Lys Asp Asp 
1               5                   10                  15      


Phe Lys Gly Leu Gln His Leu Tyr Ala Leu Val Leu Val Asn Asn Lys 
            20                  25                  30          


Ile Ser 
        


<210>  225
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  225

Ser Glu Leu Arg Lys Asp Asp Phe Lys Gly Leu Gln His Leu Tyr Ala 
1               5                   10                  15      


Leu Val Leu Val Asn Asn Lys Ile Ser Lys Ile His Glu Lys Ala Phe 
            20                  25                  30          


Ser Pro 
        


<210>  226
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  226

Leu Val Leu Val Asn Asn Lys Ile Ser Lys Ile His Glu Lys Ala Phe 
1               5                   10                  15      


Ser Pro Leu Arg Lys Leu Gln Lys Leu Tyr Ile Ser Lys Asn His Leu 
            20                  25                  30          


Val Glu 
        


<210>  227
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  227

Val Asn Asn Lys Ile Ser Lys Ile His Glu Lys Ala Phe Ser Pro Leu 
1               5                   10                  15      


Arg Lys Leu Gln Lys Leu Tyr Ile Ser Lys Asn His Leu Val Glu Ile 
            20                  25                  30          


Pro Pro 
        


<210>  228
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  228

Asn Asn Lys Ile Ser Lys Ile His Glu Lys Ala Phe Ser Pro Leu Arg 
1               5                   10                  15      


Lys Leu Gln Lys Leu Tyr Ile Ser Lys Asn His Leu Val Glu Ile Pro 
            20                  25                  30          


Pro Asn 
        


<210>  229
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  229

Ser Lys Ile His Glu Lys Ala Phe Ser Pro Leu Arg Lys Leu Gln Lys 
1               5                   10                  15      


Leu Tyr Ile Ser Lys Asn His Leu Val Glu Ile Pro Pro Asn Leu Pro 
            20                  25                  30          


Ser Ser 
        


<210>  230
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  230

Phe Ser Pro Leu Arg Lys Leu Gln Lys Leu Tyr Ile Ser Lys Asn His 
1               5                   10                  15      


Leu Val Glu Ile Pro Pro Asn Leu Pro Ser Ser Leu Val Glu Leu Arg 
            20                  25                  30          


Ile His 
        


<210>  231
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  231

Ser Lys Asn His Leu Val Glu Ile Pro Pro Asn Leu Pro Ser Ser Leu 
1               5                   10                  15      


Val Glu Leu Arg Ile His Asp Asn Arg Ile Arg Lys Val Pro Lys Gly 
            20                  25                  30          


Val Phe 
        


<210>  232
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  232

Glu Ile Pro Pro Asn Leu Pro Ser Ser Leu Val Glu Leu Arg Ile His 
1               5                   10                  15      


Asp Asn Arg Ile Arg Lys Val Pro Lys Gly Val Phe Ser Gly Leu Arg 
            20                  25                  30          


Asn Met 
        


<210>  233
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  233

Ser Leu Val Glu Leu Arg Ile His Asp Asn Arg Ile Arg Lys Val Pro 
1               5                   10                  15      


Lys Gly Val Phe Ser Gly Leu Arg Asn Met Asn Cys Ile Glu Met Gly 
            20                  25                  30          


Gly Asn 
        


<210>  234
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  234

Leu Val Glu Leu Arg Ile His Asp Asn Arg Ile Arg Lys Val Pro Lys 
1               5                   10                  15      


Gly Val Phe Ser Gly Leu Arg Asn Met Asn Cys Ile Glu Met Gly Gly 
            20                  25                  30          


Asn Pro 
        


<210>  235
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  235

Val Glu Leu Arg Ile His Asp Asn Arg Ile Arg Lys Val Pro Lys Gly 
1               5                   10                  15      


Val Phe Ser Gly Leu Arg Asn Met Asn Cys Ile Glu Met Gly Gly Asn 
            20                  25                  30          


Pro Leu 
        


<210>  236
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  236

Glu Leu Arg Ile His Asp Asn Arg Ile Arg Lys Val Pro Lys Gly Val 
1               5                   10                  15      


Phe Ser Gly Leu Arg Asn Met Asn Cys Ile Glu Met Gly Gly Asn Pro 
            20                  25                  30          


Leu Glu 
        


<210>  237
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  237

Phe Ser Gly Leu Arg Asn Met Asn Cys Ile Glu Met Gly Gly Asn Pro 
1               5                   10                  15      


Leu Glu Asn Ser Gly Phe Glu Pro Gly Ala Phe Asp Gly Leu Lys Leu 
            20                  25                  30          


Asn Tyr 
        


<210>  238
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  238

Gly Asn Pro Leu Glu Asn Ser Gly Phe Glu Pro Gly Ala Phe Asp Gly 
1               5                   10                  15      


Leu Lys Leu Asn Tyr Leu Arg Ile Ser Glu Ala Lys Leu Thr Gly Ile 
            20                  25                  30          


Pro Lys 
        


<210>  239
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  239

Gly Phe Glu Pro Gly Ala Phe Asp Gly Leu Lys Leu Asn Tyr Leu Arg 
1               5                   10                  15      


Ile Ser Glu Ala Lys Leu Thr Gly Ile Pro Lys Asp Leu Pro Glu Thr 
            20                  25                  30          


Leu Asn 
        


<210>  240
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  240

Ala Phe Asp Gly Leu Lys Leu Asn Tyr Leu Arg Ile Ser Glu Ala Lys 
1               5                   10                  15      


Leu Thr Gly Ile Pro Lys Asp Leu Pro Glu Thr Leu Asn Glu Leu His 
            20                  25                  30          


Leu Asp 
        


<210>  241
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  241

Asn Tyr Leu Arg Ile Ser Glu Ala Lys Leu Thr Gly Ile Pro Lys Asp 
1               5                   10                  15      


Leu Pro Glu Thr Leu Asn Glu Leu His Leu Asp His Asn Lys Ile Gln 
            20                  25                  30          


Ala Ile 
        


<210>  242
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  242

Ser Glu Ala Lys Leu Thr Gly Ile Pro Lys Asp Leu Pro Glu Thr Leu 
1               5                   10                  15      


Asn Glu Leu His Leu Asp His Asn Lys Ile Gln Ala Ile Glu Leu Glu 
            20                  25                  30          


Asp Leu 
        


<210>  243
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  243

Lys Leu Thr Gly Ile Pro Lys Asp Leu Pro Glu Thr Leu Asn Glu Leu 
1               5                   10                  15      


His Leu Asp His Asn Lys Ile Gln Ala Ile Glu Leu Glu Asp Leu Leu 
            20                  25                  30          


Arg Tyr 
        


<210>  244
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  244

Gly Ile Pro Lys Asp Leu Pro Glu Thr Leu Asn Glu Leu His Leu Asp 
1               5                   10                  15      


His Asn Lys Ile Gln Ala Ile Glu Leu Glu Asp Leu Leu Arg Tyr Ser 
            20                  25                  30          


Lys Leu 
        


<210>  245
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  245

Leu Asn Glu Leu His Leu Asp His Asn Lys Ile Gln Ala Ile Glu Leu 
1               5                   10                  15      


Glu Asp Leu Leu Arg Tyr Ser Lys Leu Tyr Arg Leu Gly Leu Gly His 
            20                  25                  30          


Asn Gln 
        


<210>  246
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  246

Ile Glu Leu Glu Asp Leu Leu Arg Tyr Ser Lys Leu Tyr Arg Leu Gly 
1               5                   10                  15      


Leu Gly His Asn Gln Ile Arg Met Ile Glu Asn Gly Ser Leu Ser Phe 
            20                  25                  30          


Leu Pro 
        


<210>  247
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  247

Glu Leu Glu Asp Leu Leu Arg Tyr Ser Lys Leu Tyr Arg Leu Gly Leu 
1               5                   10                  15      


Gly His Asn Gln Ile Arg Met Ile Glu Asn Gly Ser Leu Ser Phe Leu 
            20                  25                  30          


Pro Thr 
        


<210>  248
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  248

Glu Asp Leu Leu Arg Tyr Ser Lys Leu Tyr Arg Leu Gly Leu Gly His 
1               5                   10                  15      


Asn Gln Ile Arg Met Ile Glu Asn Gly Ser Leu Ser Phe Leu Pro Thr 
            20                  25                  30          


Leu Arg 
        


<210>  249
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  249

Tyr Arg Leu Gly Leu Gly His Asn Gln Ile Arg Met Ile Glu Asn Gly 
1               5                   10                  15      


Ser Leu Ser Phe Leu Pro Thr Leu Arg Glu Leu His Leu Asp Asn Asn 
            20                  25                  30          


Lys Leu 
        


<210>  250
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  250

Ser Phe Leu Pro Thr Leu Arg Glu Leu His Leu Asp Asn Asn Lys Leu 
1               5                   10                  15      


Ala Arg Val Pro Ser Gly Leu Pro Asp Leu Lys Leu Leu Gln Val Val 
            20                  25                  30          


Tyr Leu 
        


<210>  251
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  251

Phe Leu Pro Thr Leu Arg Glu Leu His Leu Asp Asn Asn Lys Leu Ala 
1               5                   10                  15      


Arg Val Pro Ser Gly Leu Pro Asp Leu Lys Leu Leu Gln Val Val Tyr 
            20                  25                  30          


Leu His 
        


<210>  252
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  252

Leu Arg Glu Leu His Leu Asp Asn Asn Lys Leu Ala Arg Val Pro Ser 
1               5                   10                  15      


Gly Leu Pro Asp Leu Lys Leu Leu Gln Val Val Tyr Leu His Ser Asn 
            20                  25                  30          


Asn Ile 
        


<210>  253
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  253

Ala Arg Val Pro Ser Gly Leu Pro Asp Leu Lys Leu Leu Gln Val Val 
1               5                   10                  15      


Tyr Leu His Ser Asn Asn Ile Thr Lys Val Gly Val Asn Asp Phe Cys 
            20                  25                  30          


Pro Met 
        


<210>  254
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  254

Arg Val Pro Ser Gly Leu Pro Asp Leu Lys Leu Leu Gln Val Val Tyr 
1               5                   10                  15      


Leu His Ser Asn Asn Ile Thr Lys Val Gly Val Asn Asp Phe Cys Pro 
            20                  25                  30          


Met Gly 
        


<210>  255
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  255

Gly Leu Pro Asp Leu Lys Leu Leu Gln Val Val Tyr Leu His Ser Asn 
1               5                   10                  15      


Asn Ile Thr Lys Val Gly Val Asn Asp Phe Cys Pro Met Gly Phe Gly 
            20                  25                  30          


Val Lys 
        


<210>  256
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  256

Val Tyr Leu His Ser Asn Asn Ile Thr Lys Val Gly Val Asn Asp Phe 
1               5                   10                  15      


Cys Pro Met Gly Phe Gly Val Lys Arg Ala Tyr Tyr Asn Gly Ile Ser 
            20                  25                  30          


Leu Phe 
        


<210>  257
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  257

Thr Lys Val Gly Val Asn Asp Phe Cys Pro Met Gly Phe Gly Val Lys 
1               5                   10                  15      


Arg Ala Tyr Tyr Asn Gly Ile Ser Leu Phe Asn Asn Pro Val Pro Tyr 
            20                  25                  30          


Trp Glu 
        


<210>  258
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  258

Gly Val Asn Asp Phe Cys Pro Met Gly Phe Gly Val Lys Arg Ala Tyr 
1               5                   10                  15      


Tyr Asn Gly Ile Ser Leu Phe Asn Asn Pro Val Pro Tyr Trp Glu Val 
            20                  25                  30          


Gln Pro 
        


<210>  259
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  259

Tyr Tyr Asn Gly Ile Ser Leu Phe Asn Asn Pro Val Pro Tyr Trp Glu 
1               5                   10                  15      


Val Gln Pro Ala Thr Phe Arg Cys Val Thr Asp Arg Leu Ala Ile Gln 
            20                  25                  30          


Phe Gly 
        


<210>  260
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  260

Ser Leu Phe Asn Asn Pro Val Pro Tyr Trp Glu Val Gln Pro Ala Thr 
1               5                   10                  15      


Phe Arg Cys Val Thr Asp Arg Leu Ala Ile Gln Phe Gly Asn Tyr Lys 
            20                  25                  30          


Lys 
    


<210>  261
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  261

Phe Asn Asn Pro Val Pro Tyr Trp Glu Val Gln Pro Ala Thr Phe Arg 
1               5                   10                  15      


Cys Val Thr Asp Arg Leu Ala Ile Gln Phe Gly Asn Tyr Lys Lys 
            20                  25                  30      


<210>  262
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  262

Asn Asn Pro Val Pro Tyr Trp Glu Val Gln Pro Ala Thr Phe Arg Cys 
1               5                   10                  15      


Val Thr Asp Arg Leu Ala Ile Gln Phe Gly Asn Tyr Lys Lys 
            20                  25                  30  


<210>  263
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human biglycan peptide

<400>  263

Thr Asp Arg Leu Ala Ile Gln Phe Gly Asn Tyr Lys Lys 
1               5                   10              


<210>  264
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  264

Leu Leu Thr Leu Ala Ala Leu Gly Ala Ser Gly Gln Gly Gln Ser Pro 
1               5                   10                  15      


Leu Gly Ser Asp Leu Gly Pro Gln Met Leu Arg Glu Leu Gln Glu Thr 
            20                  25                  30          


Asn Ala 
        


<210>  265
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  265

Leu Thr Leu Ala Ala Leu Gly Ala Ser Gly Gln Gly Gln Ser Pro Leu 
1               5                   10                  15      


Gly Ser Asp Leu Gly Pro Gln Met Leu Arg Glu Leu Gln Glu Thr Asn 
            20                  25                  30          


Ala Ala 
        


<210>  266
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  266

Leu Ala Ala Leu Gly Ala Ser Gly Gln Gly Gln Ser Pro Leu Gly Ser 
1               5                   10                  15      


Asp Leu Gly Pro Gln Met Leu Arg Glu Leu Gln Glu Thr Asn Ala Ala 
            20                  25                  30          


Leu Gln 
        


<210>  267
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  267

Ala Ala Leu Gly Ala Ser Gly Gln Gly Gln Ser Pro Leu Gly Ser Asp 
1               5                   10                  15      


Leu Gly Pro Gln Met Leu Arg Glu Leu Gln Glu Thr Asn Ala Ala Leu 
            20                  25                  30          


Gln Asp 
        


<210>  268
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  268

Ala Leu Gly Ala Ser Gly Gln Gly Gln Ser Pro Leu Gly Ser Asp Leu 
1               5                   10                  15      


Gly Pro Gln Met Leu Arg Glu Leu Gln Glu Thr Asn Ala Ala Leu Gln 
            20                  25                  30          


Asp Val 
        


<210>  269
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  269

Ser Gly Gln Gly Gln Ser Pro Leu Gly Ser Asp Leu Gly Pro Gln Met 
1               5                   10                  15      


Leu Arg Glu Leu Gln Glu Thr Asn Ala Ala Leu Gln Asp Val Arg Glu 
            20                  25                  30          


Leu Leu 
        


<210>  270
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  270

Gly Ser Asp Leu Gly Pro Gln Met Leu Arg Glu Leu Gln Glu Thr Asn 
1               5                   10                  15      


Ala Ala Leu Gln Asp Val Arg Glu Leu Leu Arg Gln Gln Val Arg Glu 
            20                  25                  30          


Ile Thr 
        


<210>  271
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  271

Ser Asp Leu Gly Pro Gln Met Leu Arg Glu Leu Gln Glu Thr Asn Ala 
1               5                   10                  15      


Ala Leu Gln Asp Val Arg Glu Leu Leu Arg Gln Gln Val Arg Glu Ile 
            20                  25                  30          


Thr Phe 
        


<210>  272
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  272

Asp Leu Gly Pro Gln Met Leu Arg Glu Leu Gln Glu Thr Asn Ala Ala 
1               5                   10                  15      


Leu Gln Asp Val Arg Glu Leu Leu Arg Gln Gln Val Arg Glu Ile Thr 
            20                  25                  30          


Phe Leu 
        


<210>  273
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  273

Arg Glu Leu Leu Arg Gln Gln Val Arg Glu Ile Thr Phe Leu Lys Asn 
1               5                   10                  15      


Thr Val Met Glu Cys Asp Ala Cys Gly Met Gln Gln Ser Val Arg Thr 
            20                  25                  30          


Gly Leu 
        


<210>  274
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  274

Thr Phe Leu Lys Asn Thr Val Met Glu Cys Asp Ala Cys Gly Met Gln 
1               5                   10                  15      


Gln Ser Val Arg Thr Gly Leu Pro Ser Val Arg Pro Leu Leu His Cys 
            20                  25                  30          


Ala Pro 
        


<210>  275
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  275

Gly Leu Pro Ser Val Arg Pro Leu Leu His Cys Ala Pro Gly Phe Cys 
1               5                   10                  15      


Phe Pro Gly Val Ala Cys Ile Gln Thr Glu Ser Gly Ala Arg Cys Gly 
            20                  25                  30          


Pro Cys 
        


<210>  276
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  276

Val Arg Pro Leu Leu His Cys Ala Pro Gly Phe Cys Phe Pro Gly Val 
1               5                   10                  15      


Ala Cys Ile Gln Thr Glu Ser Gly Ala Arg Cys Gly Pro Cys Pro Ala 
            20                  25                  30          


Gly Phe 
        


<210>  277
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  277

Gly Phe Thr Gly Asn Gly Ser His Cys Thr Asp Val Asn Glu Cys Asn 
1               5                   10                  15      


Ala His Pro Cys Phe Pro Arg Val Arg Cys Ile Asn Thr Ser Pro Gly 
            20                  25                  30          


Phe Arg 
        


<210>  278
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  278

Gly Trp Ala Gly Asn Gly Ile Leu Cys Gly Arg Asp Thr Asp Leu Asp 
1               5                   10                  15      


Gly Phe Pro Asp Glu Lys Leu Arg Cys Pro Glu Arg Gln Cys Arg Lys 
            20                  25                  30          


Asp Asn 
        


<210>  279
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  279

Thr Val Pro Asn Ser Gly Gln Glu Asp Val Asp Arg Asp Gly Ile Gly 
1               5                   10                  15      


Asp Ala Cys Asp Pro Asp Ala Asp Gly Asp Gly Val Pro Asn Glu Lys 
            20                  25                  30          


Asp Asn 
        


<210>  280
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  280

Val Arg Asn Pro Asp Gln Arg Asn Thr Asp Glu Asp Lys Trp Gly Asp 
1               5                   10                  15      


Ala Cys Asp Asn Cys Arg Ser Gln Lys Asn Asp Asp Gln Lys Asp Thr 
            20                  25                  30          


Asp Gln 
        


<210>  281
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  281

Arg Asn Pro Asp Gln Arg Asn Thr Asp Glu Asp Lys Trp Gly Asp Ala 
1               5                   10                  15      


Cys Asp Asn Cys Arg Ser Gln Lys Asn Asp Asp Gln Lys Asp Thr Asp 
            20                  25                  30          


Gln Asp 
        


<210>  282
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  282

Val Pro Asn Pro Gly Gln Glu Asp Ala Asp Arg Asp Gly Val Gly Asp 
1               5                   10                  15      


Val Cys Gln Asp Asp Phe Asp Ala Asp Lys Val Val Asp Lys Ile Asp 
            20                  25                  30          


Val Cys 
        


<210>  283
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  283

Val Asp Lys Ile Asp Val Cys Pro Glu Asn Ala Glu Val Thr Leu Thr 
1               5                   10                  15      


Asp Phe Arg Ala Phe Gln Thr Val Val Leu Asp Pro Glu Gly Asp Ala 
            20                  25                  30          


Gln Ile 
        


<210>  284
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  284

Glu Val Thr Leu Thr Asp Phe Arg Ala Phe Gln Thr Val Val Leu Asp 
1               5                   10                  15      


Pro Glu Gly Asp Ala Gln Ile Asp Pro Asn Trp Val Val Leu Asn Gln 
            20                  25                  30          


Gly Arg 
        


<210>  285
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  285

Val Val Leu Asp Pro Glu Gly Asp Ala Gln Ile Asp Pro Asn Trp Val 
1               5                   10                  15      


Val Leu Asn Gln Gly Arg Glu Ile Val Gln Thr Met Asn Ser Asp Pro 
            20                  25                  30          


Gly Leu 
        


<210>  286
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  286

Val Leu Asp Pro Glu Gly Asp Ala Gln Ile Asp Pro Asn Trp Val Val 
1               5                   10                  15      


Leu Asn Gln Gly Arg Glu Ile Val Gln Thr Met Asn Ser Asp Pro Gly 
            20                  25                  30          


Leu Ala 
        


<210>  287
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  287

Leu Asp Pro Glu Gly Asp Ala Gln Ile Asp Pro Asn Trp Val Val Leu 
1               5                   10                  15      


Asn Gln Gly Arg Glu Ile Val Gln Thr Met Asn Ser Asp Pro Gly Leu 
            20                  25                  30          


Ala Val 
        


<210>  288
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  288

Val Leu Asn Gln Gly Arg Glu Ile Val Gln Thr Met Asn Ser Asp Pro 
1               5                   10                  15      


Gly Leu Ala Val Gly Tyr Thr Ala Phe Asn Gly Val Asp Phe Glu Gly 
            20                  25                  30          


Thr Phe 
        


<210>  289
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  289

Leu Asn Gln Gly Arg Glu Ile Val Gln Thr Met Asn Ser Asp Pro Gly 
1               5                   10                  15      


Leu Ala Val Gly Tyr Thr Ala Phe Asn Gly Val Asp Phe Glu Gly Thr 
            20                  25                  30          


Phe His 
        


<210>  290
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  290

Met Asn Ser Asp Pro Gly Leu Ala Val Gly Tyr Thr Ala Phe Asn Gly 
1               5                   10                  15      


Val Asp Phe Glu Gly Thr Phe His Val Asn Thr Val Thr Asp Asp Asp 
            20                  25                  30          


Tyr Ala 
        


<210>  291
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  291

Asn Ser Asp Pro Gly Leu Ala Val Gly Tyr Thr Ala Phe Asn Gly Val 
1               5                   10                  15      


Asp Phe Glu Gly Thr Phe His Val Asn Thr Val Thr Asp Asp Asp Tyr 
            20                  25                  30          


Ala Gly 
        


<210>  292
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  292

Leu Ala Val Gly Tyr Thr Ala Phe Asn Gly Val Asp Phe Glu Gly Thr 
1               5                   10                  15      


Phe His Val Asn Thr Val Thr Asp Asp Asp Tyr Ala Gly Phe Ile Phe 
            20                  25                  30          


Gly Tyr 
        


<210>  293
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  293

Gly Tyr Thr Ala Phe Asn Gly Val Asp Phe Glu Gly Thr Phe His Val 
1               5                   10                  15      


Asn Thr Val Thr Asp Asp Asp Tyr Ala Gly Phe Ile Phe Gly Tyr Gln 
            20                  25                  30          


Asp Ser 
        


<210>  294
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  294

Asp Phe Glu Gly Thr Phe His Val Asn Thr Val Thr Asp Asp Asp Tyr 
1               5                   10                  15      


Ala Gly Phe Ile Phe Gly Tyr Gln Asp Ser Ser Ser Phe Tyr Val Val 
            20                  25                  30          


Met Trp 
        


<210>  295
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  295

Val Thr Asp Asp Asp Tyr Ala Gly Phe Ile Phe Gly Tyr Gln Asp Ser 
1               5                   10                  15      


Ser Ser Phe Tyr Val Val Met Trp Lys Gln Met Glu Gln Thr Tyr Trp 
            20                  25                  30          


Gln Ala 
        


<210>  296
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  296

Thr Asp Asp Asp Tyr Ala Gly Phe Ile Phe Gly Tyr Gln Asp Ser Ser 
1               5                   10                  15      


Ser Phe Tyr Val Val Met Trp Lys Gln Met Glu Gln Thr Tyr Trp Gln 
            20                  25                  30          


Ala Asn 
        


<210>  297
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  297

Val Val Met Trp Lys Gln Met Glu Gln Thr Tyr Trp Gln Ala Asn Pro 
1               5                   10                  15      


Phe Arg Ala Val Ala Glu Pro Gly Ile Gln Leu Lys Ala Val Lys Ser 
            20                  25                  30          


Ser Thr 
        


<210>  298
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  298

Val Met Trp Lys Gln Met Glu Gln Thr Tyr Trp Gln Ala Asn Pro Phe 
1               5                   10                  15      


Arg Ala Val Ala Glu Pro Gly Ile Gln Leu Lys Ala Val Lys Ser Ser 
            20                  25                  30          


Thr Gly 
        


<210>  299
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  299

Tyr Trp Gln Ala Asn Pro Phe Arg Ala Val Ala Glu Pro Gly Ile Gln 
1               5                   10                  15      


Leu Lys Ala Val Lys Ser Ser Thr Gly Pro Gly Glu Gln Leu Arg Asn 
            20                  25                  30          


Ala Leu 
        


<210>  300
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  300

Val Ala Glu Pro Gly Ile Gln Leu Lys Ala Val Lys Ser Ser Thr Gly 
1               5                   10                  15      


Pro Gly Glu Gln Leu Arg Asn Ala Leu Trp His Thr Gly Asp Thr Glu 
            20                  25                  30          


Ser Gln 
        


<210>  301
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  301

Ala Glu Pro Gly Ile Gln Leu Lys Ala Val Lys Ser Ser Thr Gly Pro 
1               5                   10                  15      


Gly Glu Gln Leu Arg Asn Ala Leu Trp His Thr Gly Asp Thr Glu Ser 
            20                  25                  30          


Gln Val 
        


<210>  302
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  302

Lys Ala Val Lys Ser Ser Thr Gly Pro Gly Glu Gln Leu Arg Asn Ala 
1               5                   10                  15      


Leu Trp His Thr Gly Asp Thr Glu Ser Gln Val Arg Leu Leu Trp Lys 
            20                  25                  30          


Asp Pro 
        


<210>  303
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  303

Val Lys Ser Ser Thr Gly Pro Gly Glu Gln Leu Arg Asn Ala Leu Trp 
1               5                   10                  15      


His Thr Gly Asp Thr Glu Ser Gln Val Arg Leu Leu Trp Lys Asp Pro 
            20                  25                  30          


Arg Asn 
        


<210>  304
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  304

Lys Ser Ser Thr Gly Pro Gly Glu Gln Leu Arg Asn Ala Leu Trp His 
1               5                   10                  15      


Thr Gly Asp Thr Glu Ser Gln Val Arg Leu Leu Trp Lys Asp Pro Arg 
            20                  25                  30          


Asn Val 
        


<210>  305
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  305

Ser Thr Gly Pro Gly Glu Gln Leu Arg Asn Ala Leu Trp His Thr Gly 
1               5                   10                  15      


Asp Thr Glu Ser Gln Val Arg Leu Leu Trp Lys Asp Pro Arg Asn Val 
            20                  25                  30          


Gly Trp 
        


<210>  306
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  306

Thr Gly Pro Gly Glu Gln Leu Arg Asn Ala Leu Trp His Thr Gly Asp 
1               5                   10                  15      


Thr Glu Ser Gln Val Arg Leu Leu Trp Lys Asp Pro Arg Asn Val Gly 
            20                  25                  30          


Trp Lys 
        


<210>  307
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  307

Leu Trp His Thr Gly Asp Thr Glu Ser Gln Val Arg Leu Leu Trp Lys 
1               5                   10                  15      


Asp Pro Arg Asn Val Gly Trp Lys Asp Lys Lys Ser Tyr Arg Trp Phe 
            20                  25                  30          


Leu Gln 
        


<210>  308
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  308

Leu Trp Lys Asp Pro Arg Asn Val Gly Trp Lys Asp Lys Lys Ser Tyr 
1               5                   10                  15      


Arg Trp Phe Leu Gln His Arg Pro Gln Val Gly Tyr Ile Arg Val Arg 
            20                  25                  30          


Phe Tyr 
        


<210>  309
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  309

Gly Trp Lys Asp Lys Lys Ser Tyr Arg Trp Phe Leu Gln His Arg Pro 
1               5                   10                  15      


Gln Val Gly Tyr Ile Arg Val Arg Phe Tyr Glu Gly Pro Glu Leu Val 
            20                  25                  30          


Ala Asp 
        


<210>  310
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  310

Gly Tyr Ile Arg Val Arg Phe Tyr Glu Gly Pro Glu Leu Val Ala Asp 
1               5                   10                  15      


Ser Asn Val Val Leu Asp Thr Thr Met Arg Gly Gly Arg Leu Gly Val 
            20                  25                  30          


Phe Cys 
        


<210>  311
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  311

Arg Phe Tyr Glu Gly Pro Glu Leu Val Ala Asp Ser Asn Val Val Leu 
1               5                   10                  15      


Asp Thr Thr Met Arg Gly Gly Arg Leu Gly Val Phe Cys Phe Ser Gln 
            20                  25                  30          


Glu Asn 
        


<210>  312
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  312

Ala Asp Ser Asn Val Val Leu Asp Thr Thr Met Arg Gly Gly Arg Leu 
1               5                   10                  15      


Gly Val Phe Cys Phe Ser Gln Glu Asn Ile Ile Trp Ala Asn Leu Arg 
            20                  25                  30          


Tyr Arg 
        


<210>  313
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  313

Val Leu Asp Thr Thr Met Arg Gly Gly Arg Leu Gly Val Phe Cys Phe 
1               5                   10                  15      


Ser Gln Glu Asn Ile Ile Trp Ala Asn Leu Arg Tyr Arg Cys Asn Asp 
            20                  25                  30          


Thr Ile 
        


<210>  314
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human COMP peptide

<400>  314

Leu Asp Thr Thr Met Arg Gly Gly Arg Leu Gly Val Phe Cys Phe Ser 
1               5                   10                  15      


Gln Glu Asn Ile Ile Trp Ala Asn Leu Arg Tyr Arg Cys Asn Asp Thr 
            20                  25                  30          


Ile Pro 
        


<210>  315
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  315

Leu Leu Leu Leu Ala Gln Val Ser Trp Ala Gly Pro Phe Gln Gln Arg 
1               5                   10                  15      


Gly Leu Phe Asp Phe Met Leu Glu Asp Glu Ala Ser Gly Ile Gly Pro 
            20                  25                  30          


Glu Val 
        


<210>  316
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  316

Leu Leu Ala Gln Val Ser Trp Ala Gly Pro Phe Gln Gln Arg Gly Leu 
1               5                   10                  15      


Phe Asp Phe Met Leu Glu Asp Glu Ala Ser Gly Ile Gly Pro Glu Val 
            20                  25                  30          


Pro Asp 
        


<210>  317
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  317

Leu Ala Gln Val Ser Trp Ala Gly Pro Phe Gln Gln Arg Gly Leu Phe 
1               5                   10                  15      


Asp Phe Met Leu Glu Asp Glu Ala Ser Gly Ile Gly Pro Glu Val Pro 
            20                  25                  30          


Asp Asp 
        


<210>  318
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  318

Leu Gly Pro Val Cys Pro Phe Arg Cys Gln Cys His Leu Arg Val Val 
1               5                   10                  15      


Gln Cys Ser Asp Leu Gly Leu Asp Lys Val Pro Lys Asp Leu Pro Pro 
            20                  25                  30          


Asp Thr 
        


<210>  319
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  319

Gly Leu Asp Lys Val Pro Lys Asp Leu Pro Pro Asp Thr Thr Leu Leu 
1               5                   10                  15      


Asp Leu Gln Asn Asn Lys Ile Thr Glu Ile Lys Asp Gly Asp Phe Lys 
            20                  25                  30          


Asn Leu 
        


<210>  320
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  320

Leu Leu Asp Leu Gln Asn Asn Lys Ile Thr Glu Ile Lys Asp Gly Asp 
1               5                   10                  15      


Phe Lys Asn Leu Lys Asn Leu His Ala Leu Ile Leu Val Asn Asn Lys 
            20                  25                  30          


Ile Ser 
        


<210>  321
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  321

Thr Glu Ile Lys Asp Gly Asp Phe Lys Asn Leu Lys Asn Leu His Ala 
1               5                   10                  15      


Leu Ile Leu Val Asn Asn Lys Ile Ser Lys Val Ser Pro Gly Ala Phe 
            20                  25                  30          


Thr Pro 
        


<210>  322
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  322

Lys Asn Leu His Ala Leu Ile Leu Val Asn Asn Lys Ile Ser Lys Val 
1               5                   10                  15      


Ser Pro Gly Ala Phe Thr Pro Leu Val Lys Leu Glu Arg Leu Tyr Leu 
            20                  25                  30          


Ser Lys 
        


<210>  323
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  323

Asn Asn Lys Ile Ser Lys Val Ser Pro Gly Ala Phe Thr Pro Leu Val 
1               5                   10                  15      


Lys Leu Glu Arg Leu Tyr Leu Ser Lys Asn Gln Leu Lys Glu Leu Pro 
            20                  25                  30          


Glu Lys 
        


<210>  324
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  324

Ser Lys Val Ser Pro Gly Ala Phe Thr Pro Leu Val Lys Leu Glu Arg 
1               5                   10                  15      


Leu Tyr Leu Ser Lys Asn Gln Leu Lys Glu Leu Pro Glu Lys Met Pro 
            20                  25                  30          


Lys Thr 
        


<210>  325
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  325

Lys Val Ser Pro Gly Ala Phe Thr Pro Leu Val Lys Leu Glu Arg Leu 
1               5                   10                  15      


Tyr Leu Ser Lys Asn Gln Leu Lys Glu Leu Pro Glu Lys Met Pro Lys 
            20                  25                  30          


Thr Leu 
        


<210>  326
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  326

Ser Pro Gly Ala Phe Thr Pro Leu Val Lys Leu Glu Arg Leu Tyr Leu 
1               5                   10                  15      


Ser Lys Asn Gln Leu Lys Glu Leu Pro Glu Lys Met Pro Lys Thr Leu 
            20                  25                  30          


Gln Glu 
        


<210>  327
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  327

Ala Phe Thr Pro Leu Val Lys Leu Glu Arg Leu Tyr Leu Ser Lys Asn 
1               5                   10                  15      


Gln Leu Lys Glu Leu Pro Glu Lys Met Pro Lys Thr Leu Gln Glu Leu 
            20                  25                  30          


Arg Ala 
        


<210>  328
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  328

Phe Thr Pro Leu Val Lys Leu Glu Arg Leu Tyr Leu Ser Lys Asn Gln 
1               5                   10                  15      


Leu Lys Glu Leu Pro Glu Lys Met Pro Lys Thr Leu Gln Glu Leu Arg 
            20                  25                  30          


Ala His 
        


<210>  329
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  329

Tyr Leu Ser Lys Asn Gln Leu Lys Glu Leu Pro Glu Lys Met Pro Lys 
1               5                   10                  15      


Thr Leu Gln Glu Leu Arg Ala His Glu Asn Glu Ile Thr Lys Val Arg 
            20                  25                  30          


Lys Val 
        


<210>  330
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  330

Ser Lys Asn Gln Leu Lys Glu Leu Pro Glu Lys Met Pro Lys Thr Leu 
1               5                   10                  15      


Gln Glu Leu Arg Ala His Glu Asn Glu Ile Thr Lys Val Arg Lys Val 
            20                  25                  30          


Thr Phe 
        


<210>  331
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  331

Lys Glu Leu Pro Glu Lys Met Pro Lys Thr Leu Gln Glu Leu Arg Ala 
1               5                   10                  15      


His Glu Asn Glu Ile Thr Lys Val Arg Lys Val Thr Phe Asn Gly Leu 
            20                  25                  30          


Asn Gln 
        


<210>  332
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  332

Thr Phe Asn Gly Leu Asn Gln Met Ile Val Ile Glu Leu Gly Thr Asn 
1               5                   10                  15      


Pro Leu Lys Ser Ser Gly Ile Glu Asn Gly Ala Phe Gln Gly Met Lys 
            20                  25                  30          


Lys Leu 
        


<210>  333
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  333

Val Ile Glu Leu Gly Thr Asn Pro Leu Lys Ser Ser Gly Ile Glu Asn 
1               5                   10                  15      


Gly Ala Phe Gln Gly Met Lys Lys Leu Ser Tyr Ile Arg Ile Ala Asp 
            20                  25                  30          


Thr Asn 
        


<210>  334
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  334

Gly Thr Asn Pro Leu Lys Ser Ser Gly Ile Glu Asn Gly Ala Phe Gln 
1               5                   10                  15      


Gly Met Lys Lys Leu Ser Tyr Ile Arg Ile Ala Asp Thr Asn Ile Thr 
            20                  25                  30          


Ser Ile 
        


<210>  335
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  335

Thr Asn Pro Leu Lys Ser Ser Gly Ile Glu Asn Gly Ala Phe Gln Gly 
1               5                   10                  15      


Met Lys Lys Leu Ser Tyr Ile Arg Ile Ala Asp Thr Asn Ile Thr Ser 
            20                  25                  30          


Ile Pro 
        


<210>  336
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  336

Ser Gly Ile Glu Asn Gly Ala Phe Gln Gly Met Lys Lys Leu Ser Tyr 
1               5                   10                  15      


Ile Arg Ile Ala Asp Thr Asn Ile Thr Ser Ile Pro Gln Gly Leu Pro 
            20                  25                  30          


Pro Ser 
        


<210>  337
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  337

Gly Ile Glu Asn Gly Ala Phe Gln Gly Met Lys Lys Leu Ser Tyr Ile 
1               5                   10                  15      


Arg Ile Ala Asp Thr Asn Ile Thr Ser Ile Pro Gln Gly Leu Pro Pro 
            20                  25                  30          


Ser Leu 
        


<210>  338
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  338

Ala Phe Gln Gly Met Lys Lys Leu Ser Tyr Ile Arg Ile Ala Asp Thr 
1               5                   10                  15      


Asn Ile Thr Ser Ile Pro Gln Gly Leu Pro Pro Ser Leu Thr Glu Leu 
            20                  25                  30          


His Leu 
        


<210>  339
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  339

Ser Tyr Ile Arg Ile Ala Asp Thr Asn Ile Thr Ser Ile Pro Gln Gly 
1               5                   10                  15      


Leu Pro Pro Ser Leu Thr Glu Leu His Leu Asp Gly Asn Lys Ile Ser 
            20                  25                  30          


Arg Val 
        


<210>  340
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  340

Leu Thr Glu Leu His Leu Asp Gly Asn Lys Ile Ser Arg Val Asp Ala 
1               5                   10                  15      


Ala Ser Leu Lys Gly Leu Asn Asn Leu Ala Lys Leu Gly Leu Ser Phe 
            20                  25                  30          


Asn Ser 
        


<210>  341
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  341

Ser Arg Val Asp Ala Ala Ser Leu Lys Gly Leu Asn Asn Leu Ala Lys 
1               5                   10                  15      


Leu Gly Leu Ser Phe Asn Ser Ile Ser Ala Val Asp Asn Gly Ser Leu 
            20                  25                  30          


Ala Asn 
        


<210>  342
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  342

Ala Ser Leu Lys Gly Leu Asn Asn Leu Ala Lys Leu Gly Leu Ser Phe 
1               5                   10                  15      


Asn Ser Ile Ser Ala Val Asp Asn Gly Ser Leu Ala Asn Thr Pro His 
            20                  25                  30          


Leu Arg 
        


<210>  343
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  343

Ser Leu Lys Gly Leu Asn Asn Leu Ala Lys Leu Gly Leu Ser Phe Asn 
1               5                   10                  15      


Ser Ile Ser Ala Val Asp Asn Gly Ser Leu Ala Asn Thr Pro His Leu 
            20                  25                  30          


Arg Glu 
        


<210>  344
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  344

Leu Asn Asn Leu Ala Lys Leu Gly Leu Ser Phe Asn Ser Ile Ser Ala 
1               5                   10                  15      


Val Asp Asn Gly Ser Leu Ala Asn Thr Pro His Leu Arg Glu Leu His 
            20                  25                  30          


Leu Asp 
        


<210>  345
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  345

Asn Asn Leu Ala Lys Leu Gly Leu Ser Phe Asn Ser Ile Ser Ala Val 
1               5                   10                  15      


Asp Asn Gly Ser Leu Ala Asn Thr Pro His Leu Arg Glu Leu His Leu 
            20                  25                  30          


Asp Asn 
        


<210>  346
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  346

Ala Lys Leu Gly Leu Ser Phe Asn Ser Ile Ser Ala Val Asp Asn Gly 
1               5                   10                  15      


Ser Leu Ala Asn Thr Pro His Leu Arg Glu Leu His Leu Asp Asn Asn 
            20                  25                  30          


Lys Leu 
        


<210>  347
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  347

Lys Leu Gly Leu Ser Phe Asn Ser Ile Ser Ala Val Asp Asn Gly Ser 
1               5                   10                  15      


Leu Ala Asn Thr Pro His Leu Arg Glu Leu His Leu Asp Asn Asn Lys 
            20                  25                  30          


Leu Thr 
        


<210>  348
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  348

Ser Phe Asn Ser Ile Ser Ala Val Asp Asn Gly Ser Leu Ala Asn Thr 
1               5                   10                  15      


Pro His Leu Arg Glu Leu His Leu Asp Asn Asn Lys Leu Thr Arg Val 
            20                  25                  30          


Pro Gly 
        


<210>  349
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  349

Ser Ala Val Asp Asn Gly Ser Leu Ala Asn Thr Pro His Leu Arg Glu 
1               5                   10                  15      


Leu His Leu Asp Asn Asn Lys Leu Thr Arg Val Pro Gly Gly Leu Ala 
            20                  25                  30          


Glu His 
        


<210>  350
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  350

Val Asp Asn Gly Ser Leu Ala Asn Thr Pro His Leu Arg Glu Leu His 
1               5                   10                  15      


Leu Asp Asn Asn Lys Leu Thr Arg Val Pro Gly Gly Leu Ala Glu His 
            20                  25                  30          


Lys Tyr 
        


<210>  351
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  351

Ala Asn Thr Pro His Leu Arg Glu Leu His Leu Asp Asn Asn Lys Leu 
1               5                   10                  15      


Thr Arg Val Pro Gly Gly Leu Ala Glu His Lys Tyr Ile Gln Val Val 
            20                  25                  30          


Tyr Leu 
        


<210>  352
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  352

Thr Arg Val Pro Gly Gly Leu Ala Glu His Lys Tyr Ile Gln Val Val 
1               5                   10                  15      


Tyr Leu His Asn Asn Asn Ile Ser Val Val Gly Ser Ser Asp Phe Cys 
            20                  25                  30          


Pro Pro 
        


<210>  353
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  353

Arg Val Pro Gly Gly Leu Ala Glu His Lys Tyr Ile Gln Val Val Tyr 
1               5                   10                  15      


Leu His Asn Asn Asn Ile Ser Val Val Gly Ser Ser Asp Phe Cys Pro 
            20                  25                  30          


Pro Gly 
        


<210>  354
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  354

Gly Leu Ala Glu His Lys Tyr Ile Gln Val Val Tyr Leu His Asn Asn 
1               5                   10                  15      


Asn Ile Ser Val Val Gly Ser Ser Asp Phe Cys Pro Pro Gly His Asn 
            20                  25                  30          


Thr Lys 
        


<210>  355
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  355

Val Tyr Leu His Asn Asn Asn Ile Ser Val Val Gly Ser Ser Asp Phe 
1               5                   10                  15      


Cys Pro Pro Gly His Asn Thr Lys Lys Ala Ser Tyr Ser Gly Val Ser 
            20                  25                  30          


Leu Phe 
        


<210>  356
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  356

Ser Val Val Gly Ser Ser Asp Phe Cys Pro Pro Gly His Asn Thr Lys 
1               5                   10                  15      


Lys Ala Ser Tyr Ser Gly Val Ser Leu Phe Ser Asn Pro Val Gln Tyr 
            20                  25                  30          


Trp Glu 
        


<210>  357
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  357

Val Gly Ser Ser Asp Phe Cys Pro Pro Gly His Asn Thr Lys Lys Ala 
1               5                   10                  15      


Ser Tyr Ser Gly Val Ser Leu Phe Ser Asn Pro Val Gln Tyr Trp Glu 
            20                  25                  30          


Ile Gln 
        


<210>  358
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  358

Gly Ser Ser Asp Phe Cys Pro Pro Gly His Asn Thr Lys Lys Ala Ser 
1               5                   10                  15      


Tyr Ser Gly Val Ser Leu Phe Ser Asn Pro Val Gln Tyr Trp Glu Ile 
            20                  25                  30          


Gln Pro 
        


<210>  359
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  359

Ser Tyr Ser Gly Val Ser Leu Phe Ser Asn Pro Val Gln Tyr Trp Glu 
1               5                   10                  15      


Ile Gln Pro Ser Thr Phe Arg Cys Val Tyr Val Arg Ser Ala Ile Gln 
            20                  25                  30          


Leu Gly 
        


<210>  360
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  360

Gly Val Ser Leu Phe Ser Asn Pro Val Gln Tyr Trp Glu Ile Gln Pro 
1               5                   10                  15      


Ser Thr Phe Arg Cys Val Tyr Val Arg Ser Ala Ile Gln Leu Gly Asn 
            20                  25                  30          


Tyr Lys 
        


<210>  361
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  361

Ser Leu Phe Ser Asn Pro Val Gln Tyr Trp Glu Ile Gln Pro Ser Thr 
1               5                   10                  15      


Phe Arg Cys Val Tyr Val Arg Ser Ala Ile Gln Leu Gly Asn Tyr Lys 
            20                  25                  30          


<210>  362
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  362

Phe Ser Asn Pro Val Gln Tyr Trp Glu Ile Gln Pro Ser Thr Phe Arg 
1               5                   10                  15      


Cys Val Tyr Val Arg Ser Ala Ile Gln Leu Gly Asn Tyr Lys 
            20                  25                  30  


<210>  363
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  363

Ser Asn Pro Val Gln Tyr Trp Glu Ile Gln Pro Ser Thr Phe Arg Cys 
1               5                   10                  15      


Val Tyr Val Arg Ser Ala Ile Gln Leu Gly Asn Tyr Lys 
            20                  25                  


<210>  364
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human decorin peptide

<400>  364

Ala Ile Gln Leu Gly Asn Tyr Lys 
1               5               


<210>  365
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  365

Ser Leu Leu Leu Leu Ala Gly Leu Phe Ser Leu Ser Gln Ala Gln Tyr 
1               5                   10                  15      


Glu Asp Asp Pro His Trp Trp Phe His Tyr Leu Arg Ser Gln Gln Ser 
            20                  25                  30          


Thr Tyr 
        


<210>  366
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  366

Leu Leu Leu Leu Ala Gly Leu Phe Ser Leu Ser Gln Ala Gln Tyr Glu 
1               5                   10                  15      


Asp Asp Pro His Trp Trp Phe His Tyr Leu Arg Ser Gln Gln Ser Thr 
            20                  25                  30          


Tyr Tyr 
        


<210>  367
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  367

Leu Leu Ala Gly Leu Phe Ser Leu Ser Gln Ala Gln Tyr Glu Asp Asp 
1               5                   10                  15      


Pro His Trp Trp Phe His Tyr Leu Arg Ser Gln Gln Ser Thr Tyr Tyr 
            20                  25                  30          


Asp Pro 
        


<210>  368
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  368

Leu Ala Gly Leu Phe Ser Leu Ser Gln Ala Gln Tyr Glu Asp Asp Pro 
1               5                   10                  15      


His Trp Trp Phe His Tyr Leu Arg Ser Gln Gln Ser Thr Tyr Tyr Asp 
            20                  25                  30          


Pro Tyr 
        


<210>  369
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  369

Gly Leu Phe Ser Leu Ser Gln Ala Gln Tyr Glu Asp Asp Pro His Trp 
1               5                   10                  15      


Trp Phe His Tyr Leu Arg Ser Gln Gln Ser Thr Tyr Tyr Asp Pro Tyr 
            20                  25                  30          


Asp Pro 
        


<210>  370
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  370

Leu Phe Ser Leu Ser Gln Ala Gln Tyr Glu Asp Asp Pro His Trp Trp 
1               5                   10                  15      


Phe His Tyr Leu Arg Ser Gln Gln Ser Thr Tyr Tyr Asp Pro Tyr Asp 
            20                  25                  30          


Pro Tyr 
        


<210>  371
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  371

Tyr Tyr Asp Pro Tyr Asp Pro Tyr Pro Tyr Glu Thr Tyr Glu Pro Tyr 
1               5                   10                  15      


Pro Tyr Gly Val Asp Glu Gly Pro Ala Tyr Thr Tyr Gly Ser Pro Ser 
            20                  25                  30          


Pro Pro 
        


<210>  372
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  372

Lys Tyr Leu Pro Phe Val Pro Ser Arg Met Lys Tyr Val Tyr Phe Gln 
1               5                   10                  15      


Asn Asn Gln Ile Thr Ser Ile Gln Glu Gly Val Phe Asp Asn Ala Thr 
            20                  25                  30          


Gly Leu 
        


<210>  373
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  373

Thr Ser Ile Gln Glu Gly Val Phe Asp Asn Ala Thr Gly Leu Leu Trp 
1               5                   10                  15      


Ile Ala Leu His Gly Asn Gln Ile Thr Ser Asp Lys Val Gly Arg Lys 
            20                  25                  30          


Val Phe 
        


<210>  374
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  374

Val Phe Asp Asn Ala Thr Gly Leu Leu Trp Ile Ala Leu His Gly Asn 
1               5                   10                  15      


Gln Ile Thr Ser Asp Lys Val Gly Arg Lys Val Phe Ser Lys Leu Arg 
            20                  25                  30          


His Leu 
        


<210>  375
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  375

Thr Gly Leu Leu Trp Ile Ala Leu His Gly Asn Gln Ile Thr Ser Asp 
1               5                   10                  15      


Lys Val Gly Arg Lys Val Phe Ser Lys Leu Arg His Leu Glu Arg Leu 
            20                  25                  30          


Tyr Leu 
        


<210>  376
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  376

Phe Ser Lys Leu Arg His Leu Glu Arg Leu Tyr Leu Asp His Asn Asn 
1               5                   10                  15      


Leu Thr Arg Met Pro Gly Pro Leu Pro Arg Ser Leu Arg Glu Leu His 
            20                  25                  30          


Leu Asp 
        


<210>  377
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  377

Tyr Leu Asp His Asn Asn Leu Thr Arg Met Pro Gly Pro Leu Pro Arg 
1               5                   10                  15      


Ser Leu Arg Glu Leu His Leu Asp His Asn Gln Ile Ser Arg Val Pro 
            20                  25                  30          


Asn Asn 
        


<210>  378
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  378

Arg Met Pro Gly Pro Leu Pro Arg Ser Leu Arg Glu Leu His Leu Asp 
1               5                   10                  15      


His Asn Gln Ile Ser Arg Val Pro Asn Asn Ala Leu Glu Gly Leu Glu 
            20                  25                  30          


Asn Leu 
        


<210>  379
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  379

Leu Arg Glu Leu His Leu Asp His Asn Gln Ile Ser Arg Val Pro Asn 
1               5                   10                  15      


Asn Ala Leu Glu Gly Leu Glu Asn Leu Thr Ala Leu Tyr Leu Gln His 
            20                  25                  30          


Asn Glu 
        


<210>  380
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  380

Ser Arg Val Pro Asn Asn Ala Leu Glu Gly Leu Glu Asn Leu Thr Ala 
1               5                   10                  15      


Leu Tyr Leu Gln His Asn Glu Ile Gln Glu Val Gly Ser Ser Met Arg 
            20                  25                  30          


Gly Leu 
        


<210>  381
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  381

Leu Glu Gly Leu Glu Asn Leu Thr Ala Leu Tyr Leu Gln His Asn Glu 
1               5                   10                  15      


Ile Gln Glu Val Gly Ser Ser Met Arg Gly Leu Arg Ser Leu Ile Leu 
            20                  25                  30          


Leu Asp 
        


<210>  382
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  382

Leu Tyr Leu Gln His Asn Glu Ile Gln Glu Val Gly Ser Ser Met Arg 
1               5                   10                  15      


Gly Leu Arg Ser Leu Ile Leu Leu Asp Leu Ser Tyr Asn His Leu Arg 
            20                  25                  30          


Lys Val 
        


<210>  383
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  383

Gly Ser Ser Met Arg Gly Leu Arg Ser Leu Ile Leu Leu Asp Leu Ser 
1               5                   10                  15      


Tyr Asn His Leu Arg Lys Val Pro Asp Gly Leu Pro Ser Ala Leu Glu 
            20                  25                  30          


Gln Leu 
        


<210>  384
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  384

Leu Ile Leu Leu Asp Leu Ser Tyr Asn His Leu Arg Lys Val Pro Asp 
1               5                   10                  15      


Gly Leu Pro Ser Ala Leu Glu Gln Leu Tyr Met Glu His Asn Asn Val 
            20                  25                  30          


Tyr Thr 
        


<210>  385
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  385

Leu Leu Asp Leu Ser Tyr Asn His Leu Arg Lys Val Pro Asp Gly Leu 
1               5                   10                  15      


Pro Ser Ala Leu Glu Gln Leu Tyr Met Glu His Asn Asn Val Tyr Thr 
            20                  25                  30          


Val Pro 
        


<210>  386
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  386

Ser Tyr Asn His Leu Arg Lys Val Pro Asp Gly Leu Pro Ser Ala Leu 
1               5                   10                  15      


Glu Gln Leu Tyr Met Glu His Asn Asn Val Tyr Thr Val Pro Asp Ser 
            20                  25                  30          


Tyr Phe 
        


<210>  387
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  387

Ala Leu Glu Gln Leu Tyr Met Glu His Asn Asn Val Tyr Thr Val Pro 
1               5                   10                  15      


Asp Ser Tyr Phe Arg Gly Ala Pro Lys Leu Leu Tyr Val Arg Leu Ser 
            20                  25                  30          


His Asn 
        


<210>  388
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  388

Leu Glu Gln Leu Tyr Met Glu His Asn Asn Val Tyr Thr Val Pro Asp 
1               5                   10                  15      


Ser Tyr Phe Arg Gly Ala Pro Lys Leu Leu Tyr Val Arg Leu Ser His 
            20                  25                  30          


Asn Ser 
        


<210>  389
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  389

Tyr Thr Val Pro Asp Ser Tyr Phe Arg Gly Ala Pro Lys Leu Leu Tyr 
1               5                   10                  15      


Val Arg Leu Ser His Asn Ser Leu Thr Asn Asn Gly Leu Ala Ser Asn 
            20                  25                  30          


Thr Phe 
        


<210>  390
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  390

Val Pro Asp Ser Tyr Phe Arg Gly Ala Pro Lys Leu Leu Tyr Val Arg 
1               5                   10                  15      


Leu Ser His Asn Ser Leu Thr Asn Asn Gly Leu Ala Ser Asn Thr Phe 
            20                  25                  30          


Asn Ser 
        


<210>  391
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  391

Leu Tyr Val Arg Leu Ser His Asn Ser Leu Thr Asn Asn Gly Leu Ala 
1               5                   10                  15      


Ser Asn Thr Phe Asn Ser Ser Ser Leu Leu Glu Leu Asp Leu Ser Tyr 
            20                  25                  30          


Asn Gln 
        


<210>  392
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  392

Arg Leu Ser His Asn Ser Leu Thr Asn Asn Gly Leu Ala Ser Asn Thr 
1               5                   10                  15      


Phe Asn Ser Ser Ser Leu Leu Glu Leu Asp Leu Ser Tyr Asn Gln Leu 
            20                  25                  30          


Gln Lys 
        


<210>  393
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  393

Ser His Asn Ser Leu Thr Asn Asn Gly Leu Ala Ser Asn Thr Phe Asn 
1               5                   10                  15      


Ser Ser Ser Leu Leu Glu Leu Asp Leu Ser Tyr Asn Gln Leu Gln Lys 
            20                  25                  30          


Ile Pro 
        


<210>  394
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  394

Thr Asn Asn Gly Leu Ala Ser Asn Thr Phe Asn Ser Ser Ser Leu Leu 
1               5                   10                  15      


Glu Leu Asp Leu Ser Tyr Asn Gln Leu Gln Lys Ile Pro Pro Val Asn 
            20                  25                  30          


Thr Asn 
        


<210>  395
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  395

Asn Asn Gly Leu Ala Ser Asn Thr Phe Asn Ser Ser Ser Leu Leu Glu 
1               5                   10                  15      


Leu Asp Leu Ser Tyr Asn Gln Leu Gln Lys Ile Pro Pro Val Asn Thr 
            20                  25                  30          


Asn Leu 
        


<210>  396
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  396

Phe Asn Ser Ser Ser Leu Leu Glu Leu Asp Leu Ser Tyr Asn Gln Leu 
1               5                   10                  15      


Gln Lys Ile Pro Pro Val Asn Thr Asn Leu Glu Asn Leu Tyr Leu Gln 
            20                  25                  30          


Gly Asn 
        


<210>  397
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  397

Ser Ser Leu Leu Glu Leu Asp Leu Ser Tyr Asn Gln Leu Gln Lys Ile 
1               5                   10                  15      


Pro Pro Val Asn Thr Asn Leu Glu Asn Leu Tyr Leu Gln Gly Asn Arg 
            20                  25                  30          


Ile Asn 
        


<210>  398
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  398

Ser Leu Leu Glu Leu Asp Leu Ser Tyr Asn Gln Leu Gln Lys Ile Pro 
1               5                   10                  15      


Pro Val Asn Thr Asn Leu Glu Asn Leu Tyr Leu Gln Gly Asn Arg Ile 
            20                  25                  30          


Asn Glu 
        


<210>  399
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  399

Leu Leu Glu Leu Asp Leu Ser Tyr Asn Gln Leu Gln Lys Ile Pro Pro 
1               5                   10                  15      


Val Asn Thr Asn Leu Glu Asn Leu Tyr Leu Gln Gly Asn Arg Ile Asn 
            20                  25                  30          


Glu Phe 
        


<210>  400
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  400

Leu Glu Leu Asp Leu Ser Tyr Asn Gln Leu Gln Lys Ile Pro Pro Val 
1               5                   10                  15      


Asn Thr Asn Leu Glu Asn Leu Tyr Leu Gln Gly Asn Arg Ile Asn Glu 
            20                  25                  30          


Phe Ser 
        


<210>  401
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  401

Glu Leu Asp Leu Ser Tyr Asn Gln Leu Gln Lys Ile Pro Pro Val Asn 
1               5                   10                  15      


Thr Asn Leu Glu Asn Leu Tyr Leu Gln Gly Asn Arg Ile Asn Glu Phe 
            20                  25                  30          


Ser Ile 
        


<210>  402
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  402

Tyr Asn Gln Leu Gln Lys Ile Pro Pro Val Asn Thr Asn Leu Glu Asn 
1               5                   10                  15      


Leu Tyr Leu Gln Gly Asn Arg Ile Asn Glu Phe Ser Ile Ser Ser Phe 
            20                  25                  30          


Cys Thr 
        


<210>  403
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  403

Asn Thr Asn Leu Glu Asn Leu Tyr Leu Gln Gly Asn Arg Ile Asn Glu 
1               5                   10                  15      


Phe Ser Ile Ser Ser Phe Cys Thr Val Val Asp Val Val Asn Phe Ser 
            20                  25                  30          


Lys Leu 
        


<210>  404
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  404

Asn Leu Glu Asn Leu Tyr Leu Gln Gly Asn Arg Ile Asn Glu Phe Ser 
1               5                   10                  15      


Ile Ser Ser Phe Cys Thr Val Val Asp Val Val Asn Phe Ser Lys Leu 
            20                  25                  30          


Gln Val 
        


<210>  405
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  405

Tyr Leu Gln Gly Asn Arg Ile Asn Glu Phe Ser Ile Ser Ser Phe Cys 
1               5                   10                  15      


Thr Val Val Asp Val Val Asn Phe Ser Lys Leu Gln Val Leu Arg Leu 
            20                  25                  30          


Asp Gly 
        


<210>  406
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  406

Val Val Asp Val Val Asn Phe Ser Lys Leu Gln Val Leu Arg Leu Asp 
1               5                   10                  15      


Gly Asn Glu Ile Lys Arg Ser Ala Met Pro Ala Asp Ala Pro Leu Cys 
            20                  25                  30          


Leu Arg 
        


<210>  407
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  407

Val Asp Val Val Asn Phe Ser Lys Leu Gln Val Leu Arg Leu Asp Gly 
1               5                   10                  15      


Asn Glu Ile Lys Arg Ser Ala Met Pro Ala Asp Ala Pro Leu Cys Leu 
            20                  25                  30          


Arg Leu 
        


<210>  408
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  408

Val Asn Phe Ser Lys Leu Gln Val Leu Arg Leu Asp Gly Asn Glu Ile 
1               5                   10                  15      


Lys Arg Ser Ala Met Pro Ala Asp Ala Pro Leu Cys Leu Arg Leu Ala 
            20                  25                  30          


Ser Leu 
        


<210>  409
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  409

Gln Val Leu Arg Leu Asp Gly Asn Glu Ile Lys Arg Ser Ala Met Pro 
1               5                   10                  15      


Ala Asp Ala Pro Leu Cys Leu Arg Leu Ala Ser Leu Ile Glu Ile 
            20                  25                  30      


<210>  410
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  410

Leu Arg Leu Asp Gly Asn Glu Ile Lys Arg Ser Ala Met Pro Ala Asp 
1               5                   10                  15      


Ala Pro Leu Cys Leu Arg Leu Ala Ser Leu Ile Glu Ile 
            20                  25                  


<210>  411
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  411

Arg Leu Asp Gly Asn Glu Ile Lys Arg Ser Ala Met Pro Ala Asp Ala 
1               5                   10                  15      


Pro Leu Cys Leu Arg Leu Ala Ser Leu Ile Glu Ile 
            20                  25              


<210>  412
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  412

Ala Met Pro Ala Asp Ala Pro Leu Cys Leu Arg Leu Ala Ser Leu Ile 
1               5                   10                  15      


Glu Ile 
        


<210>  413
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  413

Ala Ser Leu Ile Glu Ile 
1               5       


<210>  414
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human fibromodulin peptide

<400>  414

Ser Leu Ile Glu Ile 
1               5   


<210>  415
<211>  360
<212>  PRT
<213>  Bos taurus

<400>  415

Met Lys Ala Thr Ile Ile Phe Leu Leu Val Ala Gln Val Ser Trp Ala 
1               5                   10                  15      


Gly Pro Phe Gln Gln Lys Gly Leu Phe Asp Phe Met Leu Glu Asp Glu 
            20                  25                  30          


Ala Ser Gly Ile Gly Pro Glu Glu His Phe Pro Glu Val Pro Glu Ile 
        35                  40                  45              


Glu Pro Met Gly Pro Val Cys Pro Phe Arg Cys Gln Cys His Leu Arg 
    50                  55                  60                  


Val Val Gln Cys Ser Asp Leu Gly Leu Glu Lys Val Pro Lys Asp Leu 
65                  70                  75                  80  


Pro Pro Asp Thr Ala Leu Leu Asp Leu Gln Asn Asn Lys Ile Thr Glu 
                85                  90                  95      


Ile Lys Asp Gly Asp Phe Lys Asn Leu Lys Asn Leu His Thr Leu Ile 
            100                 105                 110         


Leu Ile Asn Asn Lys Ile Ser Lys Ile Ser Pro Gly Ala Phe Ala Pro 
        115                 120                 125             


Leu Val Lys Leu Glu Arg Leu Tyr Leu Ser Lys Asn Gln Leu Lys Glu 
    130                 135                 140                 


Leu Pro Glu Lys Met Pro Lys Thr Leu Gln Glu Leu Arg Val His Glu 
145                 150                 155                 160 


Asn Glu Ile Thr Lys Val Arg Lys Ser Val Phe Asn Gly Leu Asn Gln 
                165                 170                 175     


Met Ile Val Val Glu Leu Gly Thr Asn Pro Leu Lys Ser Ser Gly Ile 
            180                 185                 190         


Glu Asn Gly Ala Phe Gln Gly Met Lys Lys Leu Ser Tyr Ile Arg Ile 
        195                 200                 205             


Ala Asp Thr Asn Ile Thr Thr Ile Pro Gln Gly Leu Pro Pro Ser Leu 
    210                 215                 220                 


Thr Glu Leu His Leu Asp Gly Asn Lys Ile Thr Lys Val Asp Ala Ala 
225                 230                 235                 240 


Ser Leu Lys Gly Leu Asn Asn Leu Ala Lys Leu Gly Leu Ser Phe Asn 
                245                 250                 255     


Ser Ile Ser Ala Val Asp Asn Gly Ser Leu Ala Asn Thr Pro His Leu 
            260                 265                 270         


Arg Glu Leu His Leu Asn Asn Asn Lys Leu Val Lys Val Pro Gly Gly 
        275                 280                 285             


Leu Ala Asp His Lys Tyr Ile Gln Val Val Tyr Leu His Asn Asn Asn 
    290                 295                 300                 


Ile Ser Ala Ile Gly Ser Asn Asp Phe Cys Pro Pro Gly Tyr Asn Thr 
305                 310                 315                 320 


Lys Lys Ala Ser Tyr Ser Gly Val Ser Leu Phe Ser Asn Pro Val Gln 
                325                 330                 335     


Tyr Trp Glu Ile Gln Pro Ser Thr Phe Arg Cys Val Tyr Val Arg Ala 
            340                 345                 350         


Ala Val Gln Leu Gly Asn Tyr Lys 
        355                 360 


<210>  416
<211>  369
<212>  PRT
<213>  Bos taurus

<400>  416

Met Trp Pro Leu Trp Pro Leu Ala Ala Leu Leu Ala Leu Ser Gln Ala 
1               5                   10                  15      


Leu Pro Phe Glu Gln Lys Ala Phe Trp Asp Phe Thr Leu Asp Asp Gly 
            20                  25                  30          


Leu Pro Met Leu Asn Asp Glu Glu Ala Ser Gly Ala Glu Thr Thr Ser 
        35                  40                  45              


Gly Ile Pro Asp Leu Asp Ser Leu Pro Pro Thr Tyr Ser Ala Met Cys 
    50                  55                  60                  


Pro Phe Gly Cys His Cys His Leu Arg Val Val Gln Cys Ser Asp Leu 
65                  70                  75                  80  


Gly Leu Lys Ala Val Pro Lys Glu Ile Ser Pro Asp Thr Thr Leu Leu 
                85                  90                  95      


Asp Leu Gln Asn Asn Asp Ile Ser Glu Leu Arg Lys Asp Asp Phe Lys 
            100                 105                 110         


Gly Leu Gln His Leu Tyr Ala Leu Val Leu Val Asn Asn Lys Ile Ser 
        115                 120                 125             


Lys Ile His Glu Lys Ala Phe Ser Pro Leu Arg Lys Leu Gln Lys Leu 
    130                 135                 140                 


Tyr Ile Ser Lys Asn His Leu Val Glu Ile Pro Pro Asn Leu Pro Ser 
145                 150                 155                 160 


Ser Leu Val Glu Leu Arg Ile His Asp Asn Arg Ile Arg Lys Val Pro 
                165                 170                 175     


Lys Gly Val Phe Ser Gly Leu Arg Asn Met Asn Cys Ile Glu Met Gly 
            180                 185                 190         


Gly Asn Pro Leu Glu Asn Ser Gly Phe Glu Pro Gly Ala Phe Asp Gly 
        195                 200                 205             


Leu Lys Leu Asn Tyr Leu Arg Ile Ser Glu Ala Lys Leu Thr Gly Ile 
    210                 215                 220                 


Pro Lys Asp Leu Pro Glu Thr Leu Asn Glu Leu His Leu Asp His Asn 
225                 230                 235                 240 


Lys Ile Gln Ala Ile Glu Leu Glu Asp Leu Leu Arg Tyr Ser Lys Leu 
                245                 250                 255     


Tyr Arg Leu Gly Leu Gly His Asn Gln Ile Arg Met Ile Glu Asn Gly 
            260                 265                 270         


Ser Leu Ser Phe Leu Pro Thr Leu Arg Glu Leu His Leu Asp Asn Asn 
        275                 280                 285             


Lys Leu Ser Arg Val Pro Ala Gly Leu Pro Asp Leu Lys Leu Leu Gln 
    290                 295                 300                 


Val Val Tyr Leu His Thr Asn Asn Ile Thr Lys Val Gly Val Asn Asp 
305                 310                 315                 320 


Phe Cys Pro Val Gly Phe Gly Val Lys Arg Ala Tyr Tyr Asn Gly Ile 
                325                 330                 335     


Ser Leu Phe Asn Asn Pro Val Pro Tyr Trp Glu Val Gln Pro Ala Thr 
            340                 345                 350         


Phe Arg Cys Val Thr Asp Arg Leu Ala Ile Gln Phe Gly Asn Tyr Lys 
        355                 360                 365             


Lys 
    


<210>  417
<211>  376
<212>  PRT
<213>  Bos taurus

<400>  417

Met Gln Trp Ala Ser Ile Leu Leu Leu Ala Gly Leu Cys Ser Leu Ser 
1               5                   10                  15      


Trp Ala Gln Tyr Glu Glu Asp Ser His Trp Trp Phe Gln Phe Leu Arg 
            20                  25                  30          


Asn Gln Gln Ser Thr Tyr Asp Asp Pro Tyr Asp Pro Tyr Pro Tyr Glu 
        35                  40                  45              


Pro Tyr Glu Pro Tyr Pro Tyr Gly Gly Glu Glu Gly Pro Ala Tyr Ala 
    50                  55                  60                  


Tyr Gly Ser Pro Pro Gln Pro Glu Pro Arg Asp Cys Pro Gln Glu Cys 
65                  70                  75                  80  


Asp Cys Pro Pro Asn Phe Pro Thr Ala Met Tyr Cys Asp Asn Arg Asn 
                85                  90                  95      


Leu Lys Tyr Leu Pro Phe Val Pro Ser Arg Met Lys Tyr Val Tyr Phe 
            100                 105                 110         


Gln Asn Asn Gln Ile Ser Ser Ile Gln Glu Gly Val Phe Asp Asn Ala 
        115                 120                 125             


Thr Gly Leu Leu Trp Ile Ala Leu His Gly Asn Gln Ile Thr Ser Asp 
    130                 135                 140                 


Lys Val Gly Lys Lys Val Phe Ser Lys Leu Arg His Leu Glu Arg Leu 
145                 150                 155                 160 


Tyr Leu Asp His Asn Asn Leu Thr Arg Ile Pro Ser Pro Leu Pro Arg 
                165                 170                 175     


Ser Leu Arg Glu Leu His Leu Asp His Asn Gln Ile Ser Arg Val Pro 
            180                 185                 190         


Asn Asn Ala Leu Glu Gly Leu Glu Asn Leu Thr Ala Leu Tyr Leu His 
        195                 200                 205             


His Asn Glu Ile Gln Glu Val Gly Ser Ser Met Lys Gly Leu Arg Ser 
    210                 215                 220                 


Leu Ile Leu Leu Asp Leu Ser Tyr Asn His Leu Arg Lys Val Pro Asp 
225                 230                 235                 240 


Gly Leu Pro Ser Ala Leu Glu Gln Leu Tyr Leu Glu His Asn Asn Val 
                245                 250                 255     


Phe Ser Val Pro Asp Ser Tyr Phe Arg Gly Ser Pro Lys Leu Leu Tyr 
            260                 265                 270         


Val Arg Leu Ser His Asn Ser Leu Thr Asn Asn Gly Leu Ala Ser Asn 
        275                 280                 285             


Thr Phe Asn Ser Ser Ser Leu Leu Glu Leu Asp Leu Ser Tyr Asn Gln 
    290                 295                 300                 


Leu Gln Lys Ile Pro Pro Val Ser Thr Asn Leu Glu Asn Leu Tyr Leu 
305                 310                 315                 320 


Gln Gly Asn Arg Ile Asn Glu Phe Ser Ile Ser Ser Phe Cys Thr Val 
                325                 330                 335     


Val Asp Val Met Asn Phe Ser Lys Leu Gln Val Leu Arg Leu Asp Gly 
            340                 345                 350         


Asn Glu Ile Lys Arg Ser Ala Met Pro Ala Asp Ala Pro Leu Cys Leu 
        355                 360                 365             


Arg Leu Ala Ser Leu Ile Glu Ile 
    370                 375     


<210>  418
<211>  756
<212>  PRT
<213>  Bos taurus

<400>  418

Met Val Leu Ala Ala Ala Arg Val Leu Leu Leu Thr Leu Ala Ala Leu 
1               5                   10                  15      


Gly Ala Ser Gly Gln Gly Gln Met Pro Leu Gly Gly Asp Leu Gly Pro 
            20                  25                  30          


Gln Met Leu Arg Glu Leu Gln Glu Thr Asn Ala Ala Leu Gln Asp Val 
        35                  40                  45              


Arg Asp Leu Leu Arg Gln Gln Val Lys Glu Ile Thr Phe Leu Lys Asn 
    50                  55                  60                  


Thr Val Met Glu Cys Asp Ala Cys Gly Met Gln Pro Ala Arg Thr Pro 
65                  70                  75                  80  


Lys Leu Thr Val Arg Pro Leu Ser Gln Cys Ser Pro Gly Phe Cys Phe 
                85                  90                  95      


Pro Gly Val Ala Cys Thr Glu Thr Ala Asn Gly Ala Arg Cys Gly Pro 
            100                 105                 110         


Cys Pro Glu Gly Phe Thr Gly Asn Gly Ser His Cys Ala Asp Val Asn 
        115                 120                 125             


Glu Cys Thr Ala His Pro Cys Phe Pro Arg Val Arg Cys Ile Asn Thr 
    130                 135                 140                 


Ser Pro Gly Phe Arg Cys Glu Ala Cys Pro Pro Gly Phe Ser Gly Pro 
145                 150                 155                 160 


Thr His Glu Gly Val Gly Leu Ala Phe Ala Lys Ala Asn Lys Gln Val 
                165                 170                 175     


Cys Thr Asp Ile Asn Glu Cys Glu Thr Gly Gln His Asn Cys Val Pro 
            180                 185                 190         


Asn Ser Val Cys Val Asn Thr Val Gly Ser Phe Gln Cys Gly Pro Cys 
        195                 200                 205             


Gln Pro Gly Phe Val Gly Asp Gln Ala Ser Gly Cys Arg Arg Arg Pro 
    210                 215                 220                 


Gln Arg Phe Cys Pro Asp Gly Thr Pro Ser Pro Cys His Glu Lys Ala 
225                 230                 235                 240 


Asp Cys Val Leu Glu Arg Asp Gly Ser Arg Ser Cys Val Cys Ala Val 
                245                 250                 255     


Gly Trp Ala Gly Asn Gly Leu Ile Cys Gly Arg Asp Thr Asp Leu Asp 
            260                 265                 270         


Gly Phe Pro Asp Glu Lys Leu Arg Cys Ser Glu Arg Gln Cys Arg Lys 
        275                 280                 285             


Asp Asn Cys Val Thr Val Pro Asn Ser Gly Gln Glu Asp Val Asp Gln 
    290                 295                 300                 


Asp Gly Ile Gly Asp Ala Cys Asp Pro Asp Ala Asp Gly Asp Gly Val 
305                 310                 315                 320 


Leu Asn Glu Lys Asp Asn Cys Pro Leu Val Arg Asn Pro Asp Gln Arg 
                325                 330                 335     


Asn Thr Asp Gly Asp Lys Trp Gly Asp Ala Cys Asp Asn Cys Arg Ser 
            340                 345                 350         


Gln Lys Asn Asp Asp Gln Lys Asp Thr Asp Lys Asp Gly Arg Gly Asp 
        355                 360                 365             


Ala Cys Asp Asp Asp Ile Asp Gly Asp Arg Ile Arg Asn Pro Val Asp 
    370                 375                 380                 


Asn Cys Pro Lys Val Pro Asn Ser Asp Gln Lys Asp Thr Asp Gly Asp 
385                 390                 395                 400 


Gly Val Gly Asp Ala Cys Asp Asn Cys Pro Gln Lys Ser Asn Ala Asp 
                405                 410                 415     


Gln Arg Asp Val Asp His Asp Phe Val Gly Asp Ala Cys Asp Ser Asp 
            420                 425                 430         


Gln Asp Gln Asp Gly Asp Gly His Gln Asp Ser Lys Asp Asn Cys Pro 
        435                 440                 445             


Thr Val Pro Asn Ser Ala Gln Gln Asp Ser Asp His Asp Gly Gln Gly 
    450                 455                 460                 


Asp Ala Cys Asp Asp Asp Asp Asp Asn Asp Gly Val Pro Asp Ser Arg 
465                 470                 475                 480 


Asp Asn Cys Arg Leu Val Pro Asn Pro Gly Gln Glu Asp Met Asp Arg 
                485                 490                 495     


Asp Gly Val Gly Asp Ala Cys Gln Gly Asp Phe Asp Ala Asp Lys Val 
            500                 505                 510         


Val Asp Lys Ile Asp Val Cys Pro Glu Asn Ala Glu Val Thr Leu Thr 
        515                 520                 525             


Asp Phe Arg Ala Phe Gln Thr Val Val Leu Asp Pro Glu Gly Asp Ala 
    530                 535                 540                 


Gln Ile Asp Pro Asn Trp Val Val Leu Asn Gln Gly Met Glu Ile Val 
545                 550                 555                 560 


Gln Thr Met Asn Ser Asp Pro Gly Leu Ala Val Gly Tyr Thr Ala Phe 
                565                 570                 575     


Asn Gly Val Asp Phe Glu Gly Thr Phe His Val Asn Thr Ala Thr Asp 
            580                 585                 590         


Asp Asp Tyr Ala Gly Phe Ile Phe Gly Tyr Gln Asp Ser Ser Ser Phe 
        595                 600                 605             


Tyr Val Val Met Trp Lys Gln Met Glu Gln Thr Tyr Trp Gln Ala Asn 
    610                 615                 620                 


Pro Phe Arg Ala Val Ala Glu Pro Gly Ile Gln Leu Lys Ala Val Lys 
625                 630                 635                 640 


Ser Ser Thr Gly Pro Gly Glu Gln Leu Arg Asn Ala Leu Trp His Thr 
                645                 650                 655     


Gly Asp Thr Ala Ser Gln Val Arg Leu Leu Trp Lys Asp Pro Arg Asn 
            660                 665                 670         


Val Gly Trp Lys Asp Lys Thr Ser Tyr Arg Trp Phe Leu Gln His Arg 
        675                 680                 685             


Pro Gln Val Gly Tyr Ile Arg Val Arg Phe Tyr Glu Gly Pro Glu Leu 
    690                 695                 700                 


Val Ala Asp Ser Asn Val Ile Leu Asp Thr Thr Met Arg Gly Gly Arg 
705                 710                 715                 720 


Leu Gly Val Phe Cys Phe Ser Gln Glu Asn Ile Ile Trp Ala Asn Leu 
                725                 730                 735     


Arg Tyr Arg Cys Asn Asp Thr Ile Pro Glu Asp Tyr Glu Ala Gln Arg 
            740                 745                 750         


Leu Leu Gln Ala 
        755     


<210>  419
<211>  2364
<212>  PRT
<213>  Bos taurus

<400>  419

Met Thr Thr Leu Leu Leu Val Phe Val Thr Leu Arg Val Ile Thr Ala 
1               5                   10                  15      


Ala Ile Ser Val Glu Val Ser Glu Pro Asp Asn Ser Leu Ser Val Ser 
            20                  25                  30          


Ile Pro Glu Pro Ser Pro Leu Arg Val Leu Leu Gly Ser Ser Leu Thr 
        35                  40                  45              


Ile Pro Cys Tyr Phe Ile Asp Pro Met His Pro Val Thr Thr Ala Pro 
    50                  55                  60                  


Ser Thr Ala Pro Leu Ala Pro Arg Ile Lys Trp Ser Arg Ile Ser Lys 
65                  70                  75                  80  


Glu Lys Glu Val Val Leu Leu Val Ala Thr Glu Gly Arg Val Arg Val 
                85                  90                  95      


Asn Ser Ala Tyr Gln Asp Lys Val Thr Leu Pro Asn Tyr Pro Ala Ile 
            100                 105                 110         


Pro Ser Asp Ala Thr Leu Glu Ile Gln Asn Met Arg Ser Asn Asp Ser 
        115                 120                 125             


Gly Ile Leu Arg Cys Glu Val Met His Gly Ile Glu Asp Ser Gln Ala 
    130                 135                 140                 


Thr Leu Glu Val Val Val Lys Gly Ile Val Phe His Tyr Arg Ala Ile 
145                 150                 155                 160 


Ser Thr Arg Tyr Thr Leu Asp Phe Asp Arg Ala Gln Arg Ala Cys Leu 
                165                 170                 175     


Gln Asn Ser Ala Ile Ile Ala Thr Pro Glu Gln Leu Gln Ala Ala Tyr 
            180                 185                 190         


Glu Asp Gly Phe His Gln Cys Asp Ala Gly Trp Leu Ala Asp Gln Thr 
        195                 200                 205             


Val Arg Tyr Pro Ile His Thr Pro Arg Glu Gly Cys Tyr Gly Asp Lys 
    210                 215                 220                 


Asp Glu Phe Pro Gly Val Arg Thr Tyr Gly Ile Arg Asp Thr Asn Glu 
225                 230                 235                 240 


Thr Tyr Asp Val Tyr Cys Phe Ala Glu Glu Met Glu Gly Glu Val Phe 
                245                 250                 255     


Tyr Ala Thr Ser Pro Glu Lys Phe Thr Phe Gln Glu Ala Ala Asn Glu 
            260                 265                 270         


Cys Arg Arg Leu Gly Ala Arg Leu Ala Thr Thr Gly Gln Leu Tyr Leu 
        275                 280                 285             


Ala Trp Gln Gly Gly Met Asp Met Cys Ser Ala Gly Trp Leu Ala Asp 
    290                 295                 300                 


Arg Ser Val Arg Tyr Pro Ile Ser Lys Ala Arg Pro Asn Cys Gly Gly 
305                 310                 315                 320 


Asn Leu Leu Gly Val Arg Thr Val Tyr Leu His Ala Asn Gln Thr Gly 
                325                 330                 335     


Tyr Pro Asp Pro Ser Ser Arg Tyr Asp Ala Ile Cys Tyr Thr Gly Glu 
            340                 345                 350         


Asp Phe Val Asp Ile Pro Glu Ser Phe Phe Gly Val Gly Gly Glu Glu 
        355                 360                 365             


Asp Ile Thr Ile Gln Thr Val Thr Trp Pro Asp Val Glu Leu Pro Leu 
    370                 375                 380                 


Pro Arg Asn Ile Thr Glu Gly Glu Ala Arg Gly Ser Val Ile Leu Thr 
385                 390                 395                 400 


Ala Lys Pro Asp Phe Glu Val Ser Pro Thr Ala Pro Glu Pro Glu Glu 
                405                 410                 415     


Pro Phe Thr Phe Val Pro Glu Val Arg Ala Thr Ala Phe Pro Glu Val 
            420                 425                 430         


Glu Asn Arg Thr Glu Glu Ala Thr Arg Pro Trp Ala Phe Pro Arg Glu 
        435                 440                 445             


Ser Thr Pro Gly Leu Gly Ala Pro Thr Ala Phe Thr Ser Glu Asp Leu 
    450                 455                 460                 


Val Val Gln Val Thr Leu Ala Pro Gly Ala Ala Glu Val Pro Gly Gln 
465                 470                 475                 480 


Pro Arg Leu Pro Gly Gly Val Val Phe His Tyr Arg Pro Gly Ser Ser 
                485                 490                 495     


Arg Tyr Ser Leu Thr Phe Glu Glu Ala Lys Gln Ala Cys Leu Arg Thr 
            500                 505                 510         


Gly Ala Ile Ile Ala Ser Pro Glu Gln Leu Gln Ala Ala Tyr Glu Ala 
        515                 520                 525             


Gly Tyr Glu Gln Cys Asp Ala Gly Trp Leu Gln Asp Gln Thr Val Arg 
    530                 535                 540                 


Tyr Pro Ile Val Ser Pro Arg Thr Pro Cys Val Gly Asp Lys Asp Ser 
545                 550                 555                 560 


Ser Pro Gly Val Arg Thr Tyr Gly Val Arg Pro Pro Ser Glu Thr Tyr 
                565                 570                 575     


Asp Val Tyr Cys Tyr Val Asp Arg Leu Glu Gly Glu Val Phe Phe Ala 
            580                 585                 590         


Thr Arg Leu Glu Gln Phe Thr Phe Trp Glu Ala Gln Glu Phe Cys Glu 
        595                 600                 605             


Ser Gln Asn Ala Thr Leu Ala Thr Thr Gly Gln Leu Tyr Ala Ala Trp 
    610                 615                 620                 


Ser Arg Gly Leu Asp Lys Cys Tyr Ala Gly Trp Leu Ala Asp Gly Ser 
625                 630                 635                 640 


Leu Arg Tyr Pro Ile Val Thr Pro Arg Pro Ala Cys Gly Gly Asp Lys 
                645                 650                 655     


Pro Gly Val Arg Thr Val Tyr Leu Tyr Pro Asn Gln Thr Gly Leu Leu 
            660                 665                 670         


Asp Pro Leu Ser Arg His His Ala Phe Cys Phe Arg Gly Val Ser Ala 
        675                 680                 685             


Ala Pro Ser Pro Glu Glu Glu Glu Gly Ser Ala Pro Thr Ala Gly Pro 
    690                 695                 700                 


Asp Val Glu Glu Trp Met Val Thr Gln Val Gly Pro Gly Val Ala Ala 
705                 710                 715                 720 


Val Pro Ile Gly Glu Glu Thr Thr Ala Ile Pro Gly Phe Thr Val Glu 
                725                 730                 735     


Pro Glu Asn Lys Thr Glu Trp Glu Leu Ala Tyr Thr Pro Ala Gly Thr 
            740                 745                 750         


Leu Pro Leu Pro Gly Ile Pro Pro Thr Trp Pro Pro Thr Gly Glu Ala 
        755                 760                 765             


Thr Glu Glu His Thr Glu Gly Pro Ser Ala Thr Glu Val Pro Ser Ala 
    770                 775                 780                 


Ser Glu Lys Pro Phe Pro Ser Glu Glu Pro Phe Pro Pro Glu Glu Pro 
785                 790                 795                 800 


Phe Pro Ser Glu Lys Pro Phe Pro Pro Glu Glu Leu Phe Pro Ser Glu 
                805                 810                 815     


Lys Pro Phe Pro Ser Glu Lys Pro Phe Pro Ser Glu Glu Pro Phe Pro 
            820                 825                 830         


Ser Glu Lys Pro Phe Pro Pro Glu Glu Leu Phe Pro Ser Glu Lys Pro 
        835                 840                 845             


Ile Pro Ser Glu Glu Pro Phe Pro Ser Glu Glu Pro Phe Pro Ser Glu 
    850                 855                 860                 


Lys Pro Phe Pro Pro Glu Glu Pro Phe Pro Ser Glu Lys Pro Ile Pro 
865                 870                 875                 880 


Ser Glu Glu Pro Phe Pro Ser Glu Lys Pro Phe Pro Ser Glu Glu Pro 
                885                 890                 895     


Phe Pro Ser Glu Glu Pro Ser Thr Leu Ser Ala Pro Val Pro Ser Arg 
            900                 905                 910         


Thr Glu Leu Pro Ser Ser Gly Glu Val Ser Gly Val Pro Glu Ile Ser 
        915                 920                 925             


Gly Asp Phe Thr Gly Ser Gly Glu Ile Ser Gly His Leu Asp Phe Ser 
    930                 935                 940                 


Gly Gln Pro Ser Gly Glu Ser Ala Ser Gly Leu Pro Ser Glu Asp Leu 
945                 950                 955                 960 


Asp Ser Ser Gly Leu Thr Ser Thr Val Gly Ser Gly Leu Pro Val Glu 
                965                 970                 975     


Ser Gly Leu Pro Ser Gly Glu Glu Glu Arg Ile Thr Trp Thr Ser Ala 
            980                 985                 990         


Pro Lys Val Asp Arg Leu Pro Ser  Gly Gly Glu Gly Pro  Glu Val Ser 
        995                 1000                 1005             


Gly Val  Glu Asp Ile Ser Gly  Leu Pro Ser Gly Gly  Glu Val His 
    1010                 1015                 1020             


Leu Glu  Ile Ser Ala Ser Gly  Val Glu Asp Ile Ser  Gly Leu Pro 
    1025                 1030                 1035             


Ser Gly  Gly Glu Val His Leu  Glu Ile Ser Ala Ser  Gly Val Glu 
    1040                 1045                 1050             


Asp Leu  Ser Arg Ile Pro Ser  Gly Glu Gly Pro Glu  Ile Ser Ala 
    1055                 1060                 1065             


Ser Gly  Val Glu Asp Ile Ser  Gly Leu Pro Ser Gly  Glu Glu Gly 
    1070                 1075                 1080             


His Leu  Glu Ile Ser Ala Ser  Gly Val Glu Asp Leu  Ser Gly Ile 
    1085                 1090                 1095             


Pro Ser  Gly Glu Gly Pro Glu  Val Ser Ala Ser Gly  Val Glu Asp 
    1100                 1105                 1110             


Leu Ile  Gly Leu Pro Ser Gly  Glu Gly Pro Glu Val  Ser Ala Ser 
    1115                 1120                 1125             


Gly Val  Glu Asp Leu Ser Arg  Leu Pro Ser Gly Glu  Gly Pro Glu 
    1130                 1135                 1140             


Val Ser  Ala Ser Gly Val Glu  Asp Leu Ser Gly Leu  Pro Ser Gly 
    1145                 1150                 1155             


Glu Gly  Pro Glu Val Ser Val  Ser Gly Val Glu Asp  Leu Ser Arg 
    1160                 1165                 1170             


Leu Pro  Ser Gly Glu Gly Pro  Glu Val Ser Ala Ser  Gly Val Glu 
    1175                 1180                 1185             


Asp Leu  Ser Arg Leu Pro Ser  Gly Glu Gly Pro Glu  Ile Ser Val 
    1190                 1195                 1200             


Ser Gly  Val Glu Asp Ile Ser  Ile Leu Pro Ser Gly  Glu Gly Pro 
    1205                 1210                 1215             


Glu Val  Ser Ala Ser Gly Val  Glu Asp Leu Ser Val  Leu Pro Ser 
    1220                 1225                 1230             


Gly Glu  Gly His Leu Glu Ile  Ser Thr Ser Gly Val  Glu Asp Leu 
    1235                 1240                 1245             


Ser Val  Leu Pro Ser Gly Glu  Gly His Leu Glu Thr  Ser Ser Gly 
    1250                 1255                 1260             


Val Glu  Asp Ile Ser Arg Leu  Pro Ser Gly Glu Gly  Pro Glu Val 
    1265                 1270                 1275             


Ser Ala  Ser Gly Val Glu Asp  Leu Ser Val Leu Pro  Ser Gly Glu 
    1280                 1285                 1290             


Asp His  Leu Glu Ile Ser Ala  Ser Gly Val Glu Asp  Leu Gly Val 
    1295                 1300                 1305             


Leu Pro  Ser Gly Glu Asp His  Leu Glu Ile Ser Ala  Ser Gly Val 
    1310                 1315                 1320             


Glu Asp  Ile Ser Arg Leu Pro  Ser Gly Glu Gly Pro  Glu Val Ser 
    1325                 1330                 1335             


Ala Ser  Gly Val Glu Asp Leu  Ser Val Leu Pro Ser  Gly Glu Gly 
    1340                 1345                 1350             


His Leu  Glu Ile Ser Ala Ser  Gly Val Glu Asp Leu  Ser Arg Leu 
    1355                 1360                 1365             


Pro Ser  Gly Gly Glu Asp His  Leu Glu Thr Ser Ala  Ser Gly Val 
    1370                 1375                 1380             


Gly Asp  Leu Ser Gly Leu Pro  Ser Gly Arg Glu Gly  Leu Glu Ile 
    1385                 1390                 1395             


Ser Ala  Ser Gly Ala Gly Asp  Leu Ser Gly Leu Thr  Ser Gly Lys 
    1400                 1405                 1410             


Glu Asp  Leu Thr Gly Ser Ala  Ser Gly Ala Leu Asp  Leu Gly Arg 
    1415                 1420                 1425             


Ile Pro  Ser Val Thr Leu Gly  Ser Gly Gln Ala Pro  Glu Ala Ser 
    1430                 1435                 1440             


Gly Leu  Pro Ser Gly Phe Ser  Gly Glu Tyr Ser Gly  Val Asp Leu 
    1445                 1450                 1455             


Glu Ser  Gly Pro Ser Ser Gly  Leu Pro Asp Phe Ser  Gly Leu Pro 
    1460                 1465                 1470             


Ser Gly  Phe Pro Thr Val Ser  Leu Val Asp Thr Thr  Leu Val Glu 
    1475                 1480                 1485             


Val Val  Thr Ala Thr Thr Ala  Gly Glu Leu Glu Gly  Arg Gly Thr 
    1490                 1495                 1500             


Ile Asp  Ile Ser Gly Ala Gly  Glu Thr Ser Gly Leu  Pro Phe Ser 
    1505                 1510                 1515             


Glu Leu  Asp Ile Ser Gly Gly  Ala Ser Gly Leu Ser  Ser Gly Ala 
    1520                 1525                 1530             


Glu Leu  Ser Gly Gln Ala Ser  Gly Ser Pro Asp Ile  Ser Gly Glu 
    1535                 1540                 1545             


Thr Ser  Gly Leu Phe Gly Val  Ser Gly Gln Pro Ser  Gly Phe Pro 
    1550                 1555                 1560             


Asp Ile  Ser Gly Glu Thr Ser  Gly Leu Leu Glu Val  Ser Gly Gln 
    1565                 1570                 1575             


Pro Ser  Gly Phe Tyr Gly Glu  Ile Ser Gly Val Thr  Glu Leu Ser 
    1580                 1585                 1590             


Gly Leu  Ala Ser Gly Gln Pro  Glu Ile Ser Gly Glu  Ala Ser Gly 
    1595                 1600                 1605             


Ile Leu  Ser Gly Leu Gly Pro  Pro Phe Gly Ile Thr  Asp Leu Ser 
    1610                 1615                 1620             


Gly Glu  Ala Pro Gly Ile Pro  Asp Leu Ser Gly Gln  Pro Ser Gly 
    1625                 1630                 1635             


Leu Pro  Glu Phe Ser Gly Thr  Ala Ser Gly Ile Pro  Asp Leu Val 
    1640                 1645                 1650             


Ser Ser  Ala Val Ser Gly Ser  Gly Glu Ser Ser Gly  Ile Thr Phe 
    1655                 1660                 1665             


Val Asp  Thr Ser Leu Val Glu  Val Thr Pro Thr Thr  Phe Lys Glu 
    1670                 1675                 1680             


Glu Glu  Gly Leu Gly Ser Val  Glu Leu Ser Gly Leu  Pro Ser Gly 
    1685                 1690                 1695             


Glu Leu  Gly Val Ser Gly Thr  Ser Gly Leu Ala Asp  Val Ser Gly 
    1700                 1705                 1710             


Leu Ser  Ser Gly Ala Ile Asp  Ser Ser Gly Phe Thr  Ser Gln Pro 
    1715                 1720                 1725             


Pro Glu  Phe Ser Gly Leu Pro  Ser Gly Val Thr Glu  Val Ser Gly 
    1730                 1735                 1740             


Glu Ala  Ser Gly Ala Glu Ser  Gly Ser Ser Leu Pro  Ser Gly Ala 
    1745                 1750                 1755             


Tyr Asp  Ser Ser Gly Leu Pro  Ser Gly Phe Pro Thr  Val Ser Phe 
    1760                 1765                 1770             


Val Asp  Arg Thr Leu Val Glu  Ser Val Thr Gln Ala  Pro Thr Ala 
    1775                 1780                 1785             


Gln Glu  Ala Gly Glu Gly Pro  Ser Gly Ile Leu Glu  Leu Ser Gly 
    1790                 1795                 1800             


Ala Pro  Ser Gly Ala Pro Asp  Met Ser Gly Asp His  Leu Gly Ser 
    1805                 1810                 1815             


Leu Asp  Gln Ser Gly Leu Gln  Ser Gly Leu Val Glu  Pro Ser Gly 
    1820                 1825                 1830             


Glu Pro  Ala Ser Thr Pro Tyr  Phe Ser Gly Asp Phe  Ser Gly Thr 
    1835                 1840                 1845             


Thr Asp  Val Ser Gly Glu Ser  Ser Ala Ala Thr Ser  Thr Ser Gly 
    1850                 1855                 1860             


Glu Ala  Ser Gly Leu Pro Glu  Val Thr Leu Ile Thr  Ser Glu Leu 
    1865                 1870                 1875             


Val Glu  Gly Val Thr Glu Pro  Thr Val Ser Gln Glu  Leu Gly Gln 
    1880                 1885                 1890             


Arg Pro  Pro Val Thr Tyr Thr  Pro Gln Leu Phe Glu  Ser Ser Gly 
    1895                 1900                 1905             


Glu Ala  Ser Ala Ser Gly Asp  Val Pro Arg Phe Pro  Gly Ser Gly 
    1910                 1915                 1920             


Val Glu  Val Ser Ser Val Pro  Glu Ser Ser Gly Glu  Thr Ser Ala 
    1925                 1930                 1935             


Tyr Pro  Glu Ala Glu Val Gly  Ala Ser Ala Ala Pro  Glu Ala Ser 
    1940                 1945                 1950             


Gly Gly  Ala Ser Gly Ser Pro  Asn Leu Ser Glu Thr  Thr Ser Thr 
    1955                 1960                 1965             


Phe His  Glu Ala Asp Leu Glu  Gly Thr Ser Gly Leu  Gly Val Ser 
    1970                 1975                 1980             


Gly Ser  Pro Ser Ala Phe Pro  Glu Gly Pro Thr Glu  Gly Leu Ala 
    1985                 1990                 1995             


Thr Pro  Glu Val Ser Gly Glu  Ser Thr Thr Ala Phe  Asp Val Ser 
    2000                 2005                 2010             


Val Glu  Ala Ser Gly Ser Pro  Ser Ala Thr Pro Leu  Ala Ser Gly 
    2015                 2020                 2025             


Asp Arg  Thr Asp Thr Ser Gly  Asp Leu Ser Gly His  Thr Ser Gly 
    2030                 2035                 2040             


Leu Asp  Ile Val Ile Ser Thr  Thr Ile Pro Glu Ser  Glu Trp Thr 
    2045                 2050                 2055             


Gln Gln  Thr Gln Arg Pro Ala  Glu Ala Arg Leu Glu  Ile Glu Ser 
    2060                 2065                 2070             


Ser Ser  Pro Val His Ser Gly  Glu Glu Ser Gln Thr  Ala Asp Thr 
    2075                 2080                 2085             


Ala Thr  Ser Pro Thr Asp Ala  Ser Ile Pro Ala Ser  Ala Gly Gly 
    2090                 2095                 2100             


Thr Asp  Asp Ser Glu Ala Thr  Thr Thr Asp Ile Asp  Glu Cys Leu 
    2105                 2110                 2115             


Ser Ser  Pro Cys Leu Asn Gly  Ala Thr Cys Val Asp  Ala Ile Asp 
    2120                 2125                 2130             


Ser Phe  Thr Cys Leu Cys Leu  Pro Ser Tyr Gln Gly  Asp Val Cys 
    2135                 2140                 2145             


Glu Ile  Gln Lys Leu Cys Glu  Glu Gly Trp Thr Lys  Phe Gln Gly 
    2150                 2155                 2160             


His Cys  Tyr Arg His Phe Pro  Asp Arg Ala Thr Trp  Val Asp Ala 
    2165                 2170                 2175             


Glu Ser  Gln Cys Arg Lys Gln  Gln Ser His Leu Ser  Ser Ile Val 
    2180                 2185                 2190             


Thr Pro  Glu Glu Gln Glu Phe  Val Asn Asn Asn Ala  Gln Asp Tyr 
    2195                 2200                 2205             


Gln Trp  Ile Gly Leu Asn Asp  Lys Thr Ile Glu Gly  Asp Phe Arg 
    2210                 2215                 2220             


Trp Ser  Asp Gly His Ser Leu  Gln Phe Glu Asn Trp  Arg Pro Asn 
    2225                 2230                 2235             


Gln Pro  Asp Asn Phe Phe Ala  Thr Gly Glu Asp Cys  Val Val Met 
    2240                 2245                 2250             


Ile Trp  His Glu Lys Gly Glu  Trp Asn Asp Val Pro  Cys Asn Tyr 
    2255                 2260                 2265             


Gln Leu  Pro Phe Thr Cys Lys  Lys Gly Thr Val Ala  Cys Gly Glu 
    2270                 2275                 2280             


Pro Pro  Val Val Glu His Ala  Arg Ile Phe Gly Gln  Lys Lys Asp 
    2285                 2290                 2295             


Arg Tyr  Glu Ile Asn Ala Leu  Val Arg Tyr Gln Cys  Thr Glu Gly 
    2300                 2305                 2310             


Phe Ile  Gln Gly His Val Pro  Thr Ile Arg Cys Gln  Pro Ser Gly 
    2315                 2320                 2325             


His Trp  Glu Glu Pro Arg Ile  Thr Cys Thr Asp Pro  Ala Thr Tyr 
    2330                 2335                 2340             


Lys Arg  Arg Leu Gln Lys Arg  Ser Ser Arg Pro Leu  Arg Arg Ser 
    2345                 2350                 2355             


His Pro  Ser Thr Ala His 
    2360                 


<210>  420
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  420

Met Lys Ala Thr Ile Ile Leu Leu Leu Leu Ala Gln Val Ser Trp Ala 
1               5                   10                  15      


Gly Pro Phe Gln Gln Arg Gly Leu Phe Asp Phe Met Leu Glu Asp Glu 
            20                  25                  30          


Ala Ser Gly Ile Gly Pro Glu Val Pro Asp Asp Arg Asp Phe Glu Pro 
        35                  40                  45              


Ser Leu Gly Pro Val Cys Pro Phe Arg Cys Gln Cys His Leu Arg Val 
    50                  55                  60                  


Val Gln Cys Ser Asp Leu Gly Leu Asp Lys Val Pro Lys Asp Leu Pro 
65                  70                  75                  80  


Pro Asp Thr Thr Leu Leu Asp Leu Gln Asn Asn Lys Ile Thr Glu Ile 
                85                  90                  95      


Lys Asp Gly Asp Phe Lys Asn Leu Lys Asn Leu His Ala Leu Ile Leu 
            100                 105                 110         


Val Asn Asn Lys Ile Ser Lys Val Ser Pro Gly Ala Phe Thr Pro Leu 
        115                 120                 125             


Val Lys Leu Glu Arg Leu Tyr Leu Ser Lys Asn Gln Leu Lys Glu Leu 
    130                 135                 140                 


Pro Glu Lys Met Pro Lys Thr Leu Gln Glu Leu Arg Ala His Glu Asn 
145                 150                 155                 160 


Glu Ile Thr Lys Val Arg Lys Val Thr Phe Asn Gly Leu Asn Gln Met 
                165                 170                 175     


Ile Val Ile Glu Leu Gly Thr Asn Pro Leu Lys Ser Ser Gly Ile Glu 
            180                 185                 190         


Asn Gly Ala Phe Gln Gly Met Lys Lys Leu Ser Tyr Ile Arg Ile Ala 
        195                 200                 205             


Asp Thr Asn Ile Thr Ser Ile Pro Gln Gly Leu Pro Pro Ser Leu Thr 
    210                 215                 220                 


Glu Leu His Leu Asp Gly Asn Lys Ile Ser Arg Val Asp Ala Ala Ser 
225                 230                 235                 240 


Leu Lys Gly Leu Asn Asn Leu Ala Lys Leu Gly Leu Ser Phe Asn Ser 
                245                 250                 255     


Ile Ser Ala Val Asp Asn Gly Ser Leu Ala Asn Thr Pro His Leu Arg 
            260                 265                 270         


Glu Leu His Leu Asp Asn Asn Lys Leu Thr Arg Val Pro Gly Gly Leu 
        275                 280                 285             


Ala Glu His Lys Tyr Ile Gln Val Val Tyr Leu His Asn Asn Asn Ile 
    290                 295                 300                 


Ser Val Val Gly Ser Ser Asp Phe Cys Pro Pro Gly His Asn Thr Lys 
305                 310                 315                 320 


Lys Ala Ser Tyr Ser Gly Val Ser Leu Phe Ser Asn Pro Val Gln Tyr 
                325                 330                 335     


Trp Glu Ile Gln Pro Ser Thr Phe Arg Cys Val Tyr Val Arg Ser Ala 
            340                 345                 350         


Ile Gln Leu Gly Asn Tyr Lys 
        355                 


<210>  421
<211>  368
<212>  PRT
<213>  Homo sapiens

<400>  421

Met Trp Pro Leu Trp Arg Leu Val Ser Leu Leu Ala Leu Ser Gln Ala 
1               5                   10                  15      


Leu Pro Phe Glu Gln Arg Gly Phe Trp Asp Phe Thr Leu Asp Asp Gly 
            20                  25                  30          


Pro Phe Met Met Asn Asp Glu Glu Ala Ser Gly Ala Asp Thr Ser Gly 
        35                  40                  45              


Val Leu Asp Pro Asp Ser Val Thr Pro Thr Tyr Ser Ala Met Cys Pro 
    50                  55                  60                  


Phe Gly Cys His Cys His Leu Arg Val Val Gln Cys Ser Asp Leu Gly 
65                  70                  75                  80  


Leu Lys Ser Val Pro Lys Glu Ile Ser Pro Asp Thr Thr Leu Leu Asp 
                85                  90                  95      


Leu Gln Asn Asn Asp Ile Ser Glu Leu Arg Lys Asp Asp Phe Lys Gly 
            100                 105                 110         


Leu Gln His Leu Tyr Ala Leu Val Leu Val Asn Asn Lys Ile Ser Lys 
        115                 120                 125             


Ile His Glu Lys Ala Phe Ser Pro Leu Arg Lys Leu Gln Lys Leu Tyr 
    130                 135                 140                 


Ile Ser Lys Asn His Leu Val Glu Ile Pro Pro Asn Leu Pro Ser Ser 
145                 150                 155                 160 


Leu Val Glu Leu Arg Ile His Asp Asn Arg Ile Arg Lys Val Pro Lys 
                165                 170                 175     


Gly Val Phe Ser Gly Leu Arg Asn Met Asn Cys Ile Glu Met Gly Gly 
            180                 185                 190         


Asn Pro Leu Glu Asn Ser Gly Phe Glu Pro Gly Ala Phe Asp Gly Leu 
        195                 200                 205             


Lys Leu Asn Tyr Leu Arg Ile Ser Glu Ala Lys Leu Thr Gly Ile Pro 
    210                 215                 220                 


Lys Asp Leu Pro Glu Thr Leu Asn Glu Leu His Leu Asp His Asn Lys 
225                 230                 235                 240 


Ile Gln Ala Ile Glu Leu Glu Asp Leu Leu Arg Tyr Ser Lys Leu Tyr 
                245                 250                 255     


Arg Leu Gly Leu Gly His Asn Gln Ile Arg Met Ile Glu Asn Gly Ser 
            260                 265                 270         


Leu Ser Phe Leu Pro Thr Leu Arg Glu Leu His Leu Asp Asn Asn Lys 
        275                 280                 285             


Leu Ala Arg Val Pro Ser Gly Leu Pro Asp Leu Lys Leu Leu Gln Val 
    290                 295                 300                 


Val Tyr Leu His Ser Asn Asn Ile Thr Lys Val Gly Val Asn Asp Phe 
305                 310                 315                 320 


Cys Pro Met Gly Phe Gly Val Lys Arg Ala Tyr Tyr Asn Gly Ile Ser 
                325                 330                 335     


Leu Phe Asn Asn Pro Val Pro Tyr Trp Glu Val Gln Pro Ala Thr Phe 
            340                 345                 350         


Arg Cys Val Thr Asp Arg Leu Ala Ile Gln Phe Gly Asn Tyr Lys Lys 
        355                 360                 365             


<210>  422
<211>  376
<212>  PRT
<213>  Homo sapiens

<400>  422

Met Gln Trp Thr Ser Leu Leu Leu Leu Ala Gly Leu Phe Ser Leu Ser 
1               5                   10                  15      


Gln Ala Gln Tyr Glu Asp Asp Pro His Trp Trp Phe His Tyr Leu Arg 
            20                  25                  30          


Ser Gln Gln Ser Thr Tyr Tyr Asp Pro Tyr Asp Pro Tyr Pro Tyr Glu 
        35                  40                  45              


Thr Tyr Glu Pro Tyr Pro Tyr Gly Val Asp Glu Gly Pro Ala Tyr Thr 
    50                  55                  60                  


Tyr Gly Ser Pro Ser Pro Pro Asp Pro Arg Asp Cys Pro Gln Glu Cys 
65                  70                  75                  80  


Asp Cys Pro Pro Asn Phe Pro Thr Ala Met Tyr Cys Asp Asn Arg Asn 
                85                  90                  95      


Leu Lys Tyr Leu Pro Phe Val Pro Ser Arg Met Lys Tyr Val Tyr Phe 
            100                 105                 110         


Gln Asn Asn Gln Ile Thr Ser Ile Gln Glu Gly Val Phe Asp Asn Ala 
        115                 120                 125             


Thr Gly Leu Leu Trp Ile Ala Leu His Gly Asn Gln Ile Thr Ser Asp 
    130                 135                 140                 


Lys Val Gly Arg Lys Val Phe Ser Lys Leu Arg His Leu Glu Arg Leu 
145                 150                 155                 160 


Tyr Leu Asp His Asn Asn Leu Thr Arg Met Pro Gly Pro Leu Pro Arg 
                165                 170                 175     


Ser Leu Arg Glu Leu His Leu Asp His Asn Gln Ile Ser Arg Val Pro 
            180                 185                 190         


Asn Asn Ala Leu Glu Gly Leu Glu Asn Leu Thr Ala Leu Tyr Leu Gln 
        195                 200                 205             


His Asn Glu Ile Gln Glu Val Gly Ser Ser Met Arg Gly Leu Arg Ser 
    210                 215                 220                 


Leu Ile Leu Leu Asp Leu Ser Tyr Asn His Leu Arg Lys Val Pro Asp 
225                 230                 235                 240 


Gly Leu Pro Ser Ala Leu Glu Gln Leu Tyr Met Glu His Asn Asn Val 
                245                 250                 255     


Tyr Thr Val Pro Asp Ser Tyr Phe Arg Gly Ala Pro Lys Leu Leu Tyr 
            260                 265                 270         


Val Arg Leu Ser His Asn Ser Leu Thr Asn Asn Gly Leu Ala Ser Asn 
        275                 280                 285             


Thr Phe Asn Ser Ser Ser Leu Leu Glu Leu Asp Leu Ser Tyr Asn Gln 
    290                 295                 300                 


Leu Gln Lys Ile Pro Pro Val Asn Thr Asn Leu Glu Asn Leu Tyr Leu 
305                 310                 315                 320 


Gln Gly Asn Arg Ile Asn Glu Phe Ser Ile Ser Ser Phe Cys Thr Val 
                325                 330                 335     


Val Asp Val Val Asn Phe Ser Lys Leu Gln Val Leu Arg Leu Asp Gly 
            340                 345                 350         


Asn Glu Ile Lys Arg Ser Ala Met Pro Ala Asp Ala Pro Leu Cys Leu 
        355                 360                 365             


Arg Leu Ala Ser Leu Ile Glu Ile 
    370                 375     


<210>  423
<211>  757
<212>  PRT
<213>  Homo sapiens

<400>  423

Met Val Pro Asp Thr Ala Cys Val Leu Leu Leu Thr Leu Ala Ala Leu 
1               5                   10                  15      


Gly Ala Ser Gly Gln Gly Gln Ser Pro Leu Gly Ser Asp Leu Gly Pro 
            20                  25                  30          


Gln Met Leu Arg Glu Leu Gln Glu Thr Asn Ala Ala Leu Gln Asp Val 
        35                  40                  45              


Arg Glu Leu Leu Arg Gln Gln Val Arg Glu Ile Thr Phe Leu Lys Asn 
    50                  55                  60                  


Thr Val Met Glu Cys Asp Ala Cys Gly Met Gln Gln Ser Val Arg Thr 
65                  70                  75                  80  


Gly Leu Pro Ser Val Arg Pro Leu Leu His Cys Ala Pro Gly Phe Cys 
                85                  90                  95      


Phe Pro Gly Val Ala Cys Ile Gln Thr Glu Ser Gly Ala Arg Cys Gly 
            100                 105                 110         


Pro Cys Pro Ala Gly Phe Thr Gly Asn Gly Ser His Cys Thr Asp Val 
        115                 120                 125             


Asn Glu Cys Asn Ala His Pro Cys Phe Pro Arg Val Arg Cys Ile Asn 
    130                 135                 140                 


Thr Ser Pro Gly Phe Arg Cys Glu Ala Cys Pro Pro Gly Tyr Ser Gly 
145                 150                 155                 160 


Pro Thr His Gln Gly Val Gly Leu Ala Phe Ala Lys Ala Asn Lys Gln 
                165                 170                 175     


Val Cys Thr Asp Ile Asn Glu Cys Glu Thr Gly Gln His Asn Cys Val 
            180                 185                 190         


Pro Asn Ser Val Cys Ile Asn Thr Arg Gly Ser Phe Gln Cys Gly Pro 
        195                 200                 205             


Cys Gln Pro Gly Phe Val Gly Asp Gln Ala Ser Gly Cys Gln Arg Arg 
    210                 215                 220                 


Ala Gln Arg Phe Cys Pro Asp Gly Ser Pro Ser Glu Cys His Glu His 
225                 230                 235                 240 


Ala Asp Cys Val Leu Glu Arg Asp Gly Ser Arg Ser Cys Val Cys Ala 
                245                 250                 255     


Val Gly Trp Ala Gly Asn Gly Ile Leu Cys Gly Arg Asp Thr Asp Leu 
            260                 265                 270         


Asp Gly Phe Pro Asp Glu Lys Leu Arg Cys Pro Glu Arg Gln Cys Arg 
        275                 280                 285             


Lys Asp Asn Cys Val Thr Val Pro Asn Ser Gly Gln Glu Asp Val Asp 
    290                 295                 300                 


Arg Asp Gly Ile Gly Asp Ala Cys Asp Pro Asp Ala Asp Gly Asp Gly 
305                 310                 315                 320 


Val Pro Asn Glu Lys Asp Asn Cys Pro Leu Val Arg Asn Pro Asp Gln 
                325                 330                 335     


Arg Asn Thr Asp Glu Asp Lys Trp Gly Asp Ala Cys Asp Asn Cys Arg 
            340                 345                 350         


Ser Gln Lys Asn Asp Asp Gln Lys Asp Thr Asp Gln Asp Gly Arg Gly 
        355                 360                 365             


Asp Ala Cys Asp Asp Asp Ile Asp Gly Asp Arg Ile Arg Asn Gln Ala 
    370                 375                 380                 


Asp Asn Cys Pro Arg Val Pro Asn Ser Asp Gln Lys Asp Ser Asp Gly 
385                 390                 395                 400 


Asp Gly Ile Gly Asp Ala Cys Asp Asn Cys Pro Gln Lys Ser Asn Pro 
                405                 410                 415     


Asp Gln Ala Asp Val Asp His Asp Phe Val Gly Asp Ala Cys Asp Ser 
            420                 425                 430         


Asp Gln Asp Gln Asp Gly Asp Gly His Gln Asp Ser Arg Asp Asn Cys 
        435                 440                 445             


Pro Thr Val Pro Asn Ser Ala Gln Glu Asp Ser Asp His Asp Gly Gln 
    450                 455                 460                 


Gly Asp Ala Cys Asp Asp Asp Asp Asp Asn Asp Gly Val Pro Asp Ser 
465                 470                 475                 480 


Arg Asp Asn Cys Arg Leu Val Pro Asn Pro Gly Gln Glu Asp Ala Asp 
                485                 490                 495     


Arg Asp Gly Val Gly Asp Val Cys Gln Asp Asp Phe Asp Ala Asp Lys 
            500                 505                 510         


Val Val Asp Lys Ile Asp Val Cys Pro Glu Asn Ala Glu Val Thr Leu 
        515                 520                 525             


Thr Asp Phe Arg Ala Phe Gln Thr Val Val Leu Asp Pro Glu Gly Asp 
    530                 535                 540                 


Ala Gln Ile Asp Pro Asn Trp Val Val Leu Asn Gln Gly Arg Glu Ile 
545                 550                 555                 560 


Val Gln Thr Met Asn Ser Asp Pro Gly Leu Ala Val Gly Tyr Thr Ala 
                565                 570                 575     


Phe Asn Gly Val Asp Phe Glu Gly Thr Phe His Val Asn Thr Val Thr 
            580                 585                 590         


Asp Asp Asp Tyr Ala Gly Phe Ile Phe Gly Tyr Gln Asp Ser Ser Ser 
        595                 600                 605             


Phe Tyr Val Val Met Trp Lys Gln Met Glu Gln Thr Tyr Trp Gln Ala 
    610                 615                 620                 


Asn Pro Phe Arg Ala Val Ala Glu Pro Gly Ile Gln Leu Lys Ala Val 
625                 630                 635                 640 


Lys Ser Ser Thr Gly Pro Gly Glu Gln Leu Arg Asn Ala Leu Trp His 
                645                 650                 655     


Thr Gly Asp Thr Glu Ser Gln Val Arg Leu Leu Trp Lys Asp Pro Arg 
            660                 665                 670         


Asn Val Gly Trp Lys Asp Lys Lys Ser Tyr Arg Trp Phe Leu Gln His 
        675                 680                 685             


Arg Pro Gln Val Gly Tyr Ile Arg Val Arg Phe Tyr Glu Gly Pro Glu 
    690                 695                 700                 


Leu Val Ala Asp Ser Asn Val Val Leu Asp Thr Thr Met Arg Gly Gly 
705                 710                 715                 720 


Arg Leu Gly Val Phe Cys Phe Ser Gln Glu Asn Ile Ile Trp Ala Asn 
                725                 730                 735     


Leu Arg Tyr Arg Cys Asn Asp Thr Ile Pro Glu Asp Tyr Glu Thr His 
            740                 745                 750         


Gln Leu Arg Gln Ala 
        755         


<210>  424
<211>  2415
<212>  PRT
<213>  Homo sapiens

<400>  424

Met Thr Thr Leu Leu Trp Val Phe Val Thr Leu Arg Val Ile Thr Ala 
1               5                   10                  15      


Ala Val Thr Val Glu Thr Ser Asp His Asp Asn Ser Leu Ser Val Ser 
            20                  25                  30          


Ile Pro Gln Pro Ser Pro Leu Arg Val Leu Leu Gly Thr Ser Leu Thr 
        35                  40                  45              


Ile Pro Cys Tyr Phe Ile Asp Pro Met His Pro Val Thr Thr Ala Pro 
    50                  55                  60                  


Ser Thr Ala Pro Leu Ala Pro Arg Ile Lys Trp Ser Arg Val Ser Lys 
65                  70                  75                  80  


Glu Lys Glu Val Val Leu Leu Val Ala Thr Glu Gly Arg Val Arg Val 
                85                  90                  95      


Asn Ser Ala Tyr Gln Asp Lys Val Ser Leu Pro Asn Tyr Pro Ala Ile 
            100                 105                 110         


Pro Ser Asp Ala Thr Leu Glu Val Gln Ser Leu Arg Ser Asn Asp Ser 
        115                 120                 125             


Gly Val Tyr Arg Cys Glu Val Met His Gly Ile Glu Asp Ser Glu Ala 
    130                 135                 140                 


Thr Leu Glu Val Val Val Lys Gly Ile Val Phe His Tyr Arg Ala Ile 
145                 150                 155                 160 


Ser Thr Arg Tyr Thr Leu Asp Phe Asp Arg Ala Gln Arg Ala Cys Leu 
                165                 170                 175     


Gln Asn Ser Ala Ile Ile Ala Thr Pro Glu Gln Leu Gln Ala Ala Tyr 
            180                 185                 190         


Glu Asp Gly Phe His Gln Cys Asp Ala Gly Trp Leu Ala Asp Gln Thr 
        195                 200                 205             


Val Arg Tyr Pro Ile His Thr Pro Arg Glu Gly Cys Tyr Gly Asp Lys 
    210                 215                 220                 


Asp Glu Phe Pro Gly Val Arg Thr Tyr Gly Ile Arg Asp Thr Asn Glu 
225                 230                 235                 240 


Thr Tyr Asp Val Tyr Cys Phe Ala Glu Glu Met Glu Gly Glu Val Phe 
                245                 250                 255     


Tyr Ala Thr Ser Pro Glu Lys Phe Thr Phe Gln Glu Ala Ala Asn Glu 
            260                 265                 270         


Cys Arg Arg Leu Gly Ala Arg Leu Ala Thr Thr Gly His Val Tyr Leu 
        275                 280                 285             


Ala Trp Gln Ala Gly Met Asp Met Cys Ser Ala Gly Trp Leu Ala Asp 
    290                 295                 300                 


Arg Ser Val Arg Tyr Pro Ile Ser Lys Ala Arg Pro Asn Cys Gly Gly 
305                 310                 315                 320 


Asn Leu Leu Gly Val Arg Thr Val Tyr Val His Ala Asn Gln Thr Gly 
                325                 330                 335     


Tyr Pro Asp Pro Ser Ser Arg Tyr Asp Ala Ile Cys Tyr Thr Gly Glu 
            340                 345                 350         


Asp Phe Val Asp Ile Pro Glu Asn Phe Phe Gly Val Gly Gly Glu Glu 
        355                 360                 365             


Asp Ile Thr Val Gln Thr Val Thr Trp Pro Asp Met Glu Leu Pro Leu 
    370                 375                 380                 


Pro Arg Asn Ile Thr Glu Gly Glu Ala Arg Gly Ser Val Ile Leu Thr 
385                 390                 395                 400 


Val Lys Pro Ile Phe Glu Val Ser Pro Ser Pro Leu Glu Pro Glu Glu 
                405                 410                 415     


Pro Phe Thr Phe Ala Pro Glu Ile Gly Ala Thr Ala Phe Ala Glu Val 
            420                 425                 430         


Glu Asn Glu Thr Gly Glu Ala Thr Arg Pro Trp Gly Phe Pro Thr Pro 
        435                 440                 445             


Gly Leu Gly Pro Ala Thr Ala Phe Thr Ser Glu Asp Leu Val Val Gln 
    450                 455                 460                 


Val Thr Ala Val Pro Gly Gln Pro His Leu Pro Gly Gly Val Val Phe 
465                 470                 475                 480 


His Tyr Arg Pro Gly Pro Thr Arg Tyr Ser Leu Thr Phe Glu Glu Ala 
                485                 490                 495     


Gln Gln Ala Cys Pro Gly Thr Gly Ala Val Ile Ala Ser Pro Glu Gln 
            500                 505                 510         


Leu Gln Ala Ala Tyr Glu Ala Gly Tyr Glu Gln Cys Asp Ala Gly Trp 
        515                 520                 525             


Leu Arg Asp Gln Thr Val Arg Tyr Pro Ile Val Ser Pro Arg Thr Pro 
    530                 535                 540                 


Cys Val Gly Asp Lys Asp Ser Ser Pro Gly Val Arg Thr Tyr Gly Val 
545                 550                 555                 560 


Arg Pro Ser Thr Glu Thr Tyr Asp Val Tyr Cys Phe Val Asp Arg Leu 
                565                 570                 575     


Glu Gly Glu Val Phe Phe Ala Thr Arg Leu Glu Gln Phe Thr Phe Gln 
            580                 585                 590         


Glu Ala Leu Glu Phe Cys Glu Ser His Asn Ala Thr Ala Thr Thr Gly 
        595                 600                 605             


Gln Leu Tyr Ala Ala Trp Ser Arg Gly Leu Asp Lys Cys Tyr Ala Gly 
    610                 615                 620                 


Trp Leu Ala Asp Gly Ser Leu Arg Tyr Pro Ile Val Thr Pro Arg Pro 
625                 630                 635                 640 


Ala Cys Gly Gly Asp Lys Pro Gly Val Arg Thr Val Tyr Leu Tyr Pro 
                645                 650                 655     


Asn Gln Thr Gly Leu Pro Asp Pro Leu Ser Arg His His Ala Phe Cys 
            660                 665                 670         


Phe Arg Gly Ile Ser Ala Val Pro Ser Pro Gly Glu Glu Glu Gly Gly 
        675                 680                 685             


Thr Pro Thr Ser Pro Ser Gly Val Glu Glu Trp Ile Val Thr Gln Val 
    690                 695                 700                 


Val Pro Gly Val Ala Ala Val Pro Val Glu Glu Glu Thr Thr Ala Val 
705                 710                 715                 720 


Pro Ser Gly Glu Thr Thr Ala Ile Leu Glu Phe Thr Thr Glu Pro Glu 
                725                 730                 735     


Asn Gln Thr Glu Trp Glu Pro Ala Tyr Thr Pro Val Gly Thr Ser Pro 
            740                 745                 750         


Leu Pro Gly Ile Leu Pro Thr Trp Pro Pro Thr Gly Ala Glu Thr Glu 
        755                 760                 765             


Glu Ser Thr Glu Gly Pro Ser Ala Thr Glu Val Pro Ser Ala Ser Glu 
    770                 775                 780                 


Glu Pro Ser Pro Ser Glu Val Pro Phe Pro Ser Glu Glu Pro Ser Pro 
785                 790                 795                 800 


Ser Glu Glu Pro Phe Pro Ser Val Arg Pro Phe Pro Ser Val Glu Leu 
                805                 810                 815     


Phe Pro Ser Glu Glu Pro Phe Pro Ser Lys Glu Pro Ser Pro Ser Glu 
            820                 825                 830         


Glu Pro Ser Ala Ser Glu Glu Pro Tyr Thr Pro Ser Pro Pro Glu Pro 
        835                 840                 845             


Ser Trp Thr Glu Leu Pro Ser Ser Gly Glu Glu Ser Gly Ala Pro Asp 
    850                 855                 860                 


Val Ser Gly Asp Phe Thr Gly Ser Gly Asp Val Ser Gly His Leu Asp 
865                 870                 875                 880 


Phe Ser Gly Gln Leu Ser Gly Asp Arg Ala Ser Gly Leu Pro Ser Gly 
                885                 890                 895     


Asp Leu Asp Ser Ser Gly Leu Thr Ser Thr Val Gly Ser Gly Leu Thr 
            900                 905                 910         


Val Glu Ser Gly Leu Pro Ser Gly Asp Glu Glu Arg Ile Glu Trp Pro 
        915                 920                 925             


Ser Thr Pro Thr Val Gly Glu Leu Pro Ser Gly Ala Glu Ile Leu Glu 
    930                 935                 940                 


Gly Ser Ala Ser Gly Val Gly Asp Leu Ser Gly Leu Pro Ser Gly Glu 
945                 950                 955                 960 


Val Leu Glu Thr Ser Ala Ser Gly Val Gly Asp Leu Ser Gly Leu Pro 
                965                 970                 975     


Ser Gly Glu Val Leu Glu Thr Thr Ala Pro Gly Val Glu Asp Ile Ser 
            980                 985                 990         


Gly Leu Pro Ser Gly Glu Val Leu  Glu Thr Thr Ala Pro  Gly Val Glu 
        995                 1000                 1005             


Asp Ile  Ser Gly Leu Pro Ser  Gly Glu Val Leu Glu  Thr Thr Ala 
    1010                 1015                 1020             


Pro Gly  Val Glu Asp Ile Ser  Gly Leu Pro Ser Gly  Glu Val Leu 
    1025                 1030                 1035             


Glu Thr  Thr Ala Pro Gly Val  Glu Asp Ile Ser Gly  Leu Pro Ser 
    1040                 1045                 1050             


Gly Glu  Val Leu Glu Thr Thr  Ala Pro Gly Val Glu  Asp Ile Ser 
    1055                 1060                 1065             


Gly Leu  Pro Ser Gly Glu Val  Leu Glu Thr Ala Ala  Pro Gly Val 
    1070                 1075                 1080             


Glu Asp  Ile Ser Gly Leu Pro  Ser Gly Glu Val Leu  Glu Thr Ala 
    1085                 1090                 1095             


Ala Pro  Gly Val Glu Asp Ile  Ser Gly Leu Pro Ser  Gly Glu Val 
    1100                 1105                 1110             


Leu Glu  Thr Ala Ala Pro Gly  Val Glu Asp Ile Ser  Gly Leu Pro 
    1115                 1120                 1125             


Ser Gly  Glu Val Leu Glu Thr  Ala Ala Pro Gly Val  Glu Asp Ile 
    1130                 1135                 1140             


Ser Gly  Leu Pro Ser Gly Glu  Val Leu Glu Thr Ala  Ala Pro Gly 
    1145                 1150                 1155             


Val Glu  Asp Ile Ser Gly Leu  Pro Ser Gly Glu Val  Leu Glu Thr 
    1160                 1165                 1170             


Ala Ala  Pro Gly Val Glu Asp  Ile Ser Gly Leu Pro  Ser Gly Glu 
    1175                 1180                 1185             


Val Leu  Glu Thr Ala Ala Pro  Gly Val Glu Asp Ile  Ser Gly Leu 
    1190                 1195                 1200             


Pro Ser  Gly Glu Val Leu Glu  Thr Ala Ala Pro Gly  Val Glu Asp 
    1205                 1210                 1215             


Ile Ser  Gly Leu Pro Ser Gly  Glu Val Leu Glu Thr  Ala Ala Pro 
    1220                 1225                 1230             


Gly Val  Glu Asp Ile Ser Gly  Leu Pro Ser Gly Glu  Val Leu Glu 
    1235                 1240                 1245             


Thr Ala  Ala Pro Gly Val Glu  Asp Ile Ser Gly Leu  Pro Ser Gly 
    1250                 1255                 1260             


Glu Val  Leu Glu Thr Ala Ala  Pro Gly Val Glu Asp  Ile Ser Gly 
    1265                 1270                 1275             


Leu Pro  Ser Gly Glu Val Leu  Glu Thr Thr Ala Pro  Gly Val Glu 
    1280                 1285                 1290             


Glu Ile  Ser Gly Leu Pro Ser  Gly Glu Val Leu Glu  Thr Thr Ala 
    1295                 1300                 1305             


Pro Gly  Val Asp Glu Ile Ser  Gly Leu Pro Ser Gly  Glu Val Leu 
    1310                 1315                 1320             


Glu Thr  Thr Ala Pro Gly Val  Glu Glu Ile Ser Gly  Leu Pro Ser 
    1325                 1330                 1335             


Gly Glu  Val Leu Glu Thr Ser  Thr Ser Ala Val Gly  Asp Leu Ser 
    1340                 1345                 1350             


Gly Leu  Pro Ser Gly Gly Glu  Val Leu Glu Ile Ser  Val Ser Gly 
    1355                 1360                 1365             


Val Glu  Asp Ile Ser Gly Leu  Pro Ser Gly Glu Val  Val Glu Thr 
    1370                 1375                 1380             


Ser Ala  Ser Gly Ile Glu Asp  Val Ser Glu Leu Pro  Ser Gly Glu 
    1385                 1390                 1395             


Gly Leu  Glu Thr Ser Ala Ser  Gly Val Glu Asp Leu  Ser Arg Leu 
    1400                 1405                 1410             


Pro Ser  Gly Glu Glu Val Leu  Glu Ile Ser Ala Ser  Gly Phe Gly 
    1415                 1420                 1425             


Asp Leu  Ser Gly Val Pro Ser  Gly Gly Glu Gly Leu  Glu Thr Ser 
    1430                 1435                 1440             


Ala Ser  Glu Val Gly Thr Asp  Leu Ser Gly Leu Pro  Ser Gly Arg 
    1445                 1450                 1455             


Glu Gly  Leu Glu Thr Ser Ala  Ser Gly Ala Glu Asp  Leu Ser Gly 
    1460                 1465                 1470             


Leu Pro  Ser Gly Lys Glu Asp  Leu Val Gly Ser Ala  Ser Gly Asp 
    1475                 1480                 1485             


Leu Asp  Leu Gly Lys Leu Pro  Ser Gly Thr Leu Gly  Ser Gly Gln 
    1490                 1495                 1500             


Ala Pro  Glu Thr Ser Gly Leu  Pro Ser Gly Phe Ser  Gly Glu Tyr 
    1505                 1510                 1515             


Ser Gly  Val Asp Leu Gly Ser  Gly Pro Pro Ser Gly  Leu Pro Asp 
    1520                 1525                 1530             


Phe Ser  Gly Leu Pro Ser Gly  Phe Pro Thr Val Ser  Leu Val Asp 
    1535                 1540                 1545             


Ser Thr  Leu Val Glu Val Val  Thr Ala Ser Thr Ala  Ser Glu Leu 
    1550                 1555                 1560             


Glu Gly  Arg Gly Thr Ile Gly  Ile Ser Gly Ala Gly  Glu Ile Ser 
    1565                 1570                 1575             


Gly Leu  Pro Ser Ser Glu Leu  Asp Ile Ser Gly Arg  Ala Ser Gly 
    1580                 1585                 1590             


Leu Pro  Ser Gly Thr Glu Leu  Ser Gly Gln Ala Ser  Gly Ser Pro 
    1595                 1600                 1605             


Asp Val  Ser Gly Glu Ile Pro  Gly Leu Phe Gly Val  Ser Gly Gln 
    1610                 1615                 1620             


Pro Ser  Gly Phe Pro Asp Thr  Ser Gly Glu Thr Ser  Gly Val Thr 
    1625                 1630                 1635             


Glu Leu  Ser Gly Leu Ser Ser  Gly Gln Pro Gly Val  Ser Gly Glu 
    1640                 1645                 1650             


Ala Ser  Gly Val Leu Tyr Gly  Thr Ser Gln Pro Phe  Gly Ile Thr 
    1655                 1660                 1665             


Asp Leu  Ser Gly Glu Thr Ser  Gly Val Pro Asp Leu  Ser Gly Gln 
    1670                 1675                 1680             


Pro Ser  Gly Leu Pro Gly Phe  Ser Gly Ala Thr Ser  Gly Val Pro 
    1685                 1690                 1695             


Asp Leu  Val Ser Gly Thr Thr  Ser Gly Ser Gly Glu  Ser Ser Gly 
    1700                 1705                 1710             


Ile Thr  Phe Val Asp Thr Ser  Leu Val Glu Val Ala  Pro Thr Thr 
    1715                 1720                 1725             


Phe Lys  Glu Glu Glu Gly Leu  Gly Ser Val Glu Leu  Ser Gly Leu 
    1730                 1735                 1740             


Pro Ser  Gly Glu Ala Asp Leu  Ser Gly Lys Ser Gly  Met Val Asp 
    1745                 1750                 1755             


Val Ser  Gly Gln Phe Ser Gly  Thr Val Asp Ser Ser  Gly Phe Thr 
    1760                 1765                 1770             


Ser Gln  Thr Pro Glu Phe Ser  Gly Leu Pro Ser Gly  Ile Ala Glu 
    1775                 1780                 1785             


Val Ser  Gly Glu Ser Ser Arg  Ala Glu Ile Gly Ser  Ser Leu Pro 
    1790                 1795                 1800             


Ser Gly  Ala Tyr Tyr Gly Ser  Gly Thr Pro Ser Ser  Phe Pro Thr 
    1805                 1810                 1815             


Val Ser  Leu Val Asp Arg Thr  Leu Val Glu Ser Val  Thr Gln Ala 
    1820                 1825                 1830             


Pro Thr  Ala Gln Glu Ala Gly  Glu Gly Pro Ser Gly  Ile Leu Glu 
    1835                 1840                 1845             


Leu Ser  Gly Ala His Ser Gly  Ala Pro Asp Met Ser  Gly Glu His 
    1850                 1855                 1860             


Ser Gly  Phe Leu Asp Leu Ser  Gly Leu Gln Ser Gly  Leu Ile Glu 
    1865                 1870                 1875             


Pro Ser  Gly Glu Pro Pro Gly  Thr Pro Tyr Phe Ser  Gly Asp Phe 
    1880                 1885                 1890             


Ala Ser  Thr Thr Asn Val Ser  Gly Glu Ser Ser Val  Ala Met Gly 
    1895                 1900                 1905             


Thr Ser  Gly Glu Ala Ser Gly  Leu Pro Glu Val Thr  Leu Ile Thr 
    1910                 1915                 1920             


Ser Glu  Phe Val Glu Gly Val  Thr Glu Pro Thr Ile  Ser Gln Glu 
    1925                 1930                 1935             


Leu Gly  Gln Arg Pro Pro Val  Thr His Thr Pro Gln  Leu Phe Glu 
    1940                 1945                 1950             


Ser Ser  Gly Lys Val Ser Thr  Ala Gly Asp Ile Ser  Gly Ala Thr 
    1955                 1960                 1965             


Pro Val  Leu Pro Gly Ser Gly  Val Glu Val Ser Ser  Val Pro Glu 
    1970                 1975                 1980             


Ser Ser  Ser Glu Thr Ser Ala  Tyr Pro Glu Ala Gly  Phe Gly Ala 
    1985                 1990                 1995             


Ser Ala  Ala Pro Glu Ala Ser  Arg Glu Asp Ser Gly  Ser Pro Asp 
    2000                 2005                 2010             


Leu Ser  Glu Thr Thr Ser Ala  Phe His Glu Ala Asn  Leu Glu Arg 
    2015                 2020                 2025             


Ser Ser  Gly Leu Gly Val Ser  Gly Ser Thr Leu Thr  Phe Gln Glu 
    2030                 2035                 2040             


Gly Glu  Ala Ser Ala Ala Pro  Glu Val Ser Gly Glu  Ser Thr Thr 
    2045                 2050                 2055             


Thr Ser  Asp Val Gly Thr Glu  Ala Pro Gly Leu Pro  Ser Ala Thr 
    2060                 2065                 2070             


Pro Thr  Ala Ser Gly Asp Arg  Thr Glu Ile Ser Gly  Asp Leu Ser 
    2075                 2080                 2085             


Gly His  Thr Ser Gln Leu Gly  Val Val Ile Ser Thr  Ser Ile Pro 
    2090                 2095                 2100             


Glu Ser  Glu Trp Thr Gln Gln  Thr Gln Arg Pro Ala  Glu Thr His 
    2105                 2110                 2115             


Leu Glu  Ile Glu Ser Ser Ser  Leu Leu Tyr Ser Gly  Glu Glu Thr 
    2120                 2125                 2130             


His Thr  Val Glu Thr Ala Thr  Ser Pro Thr Asp Ala  Ser Ile Pro 
    2135                 2140                 2145             


Ala Ser  Pro Glu Trp Lys Arg  Glu Ser Glu Ser Thr  Ala Ala Ala 
    2150                 2155                 2160             


Pro Ala  Arg Ser Cys Ala Glu  Glu Pro Cys Gly Ala  Gly Thr Cys 
    2165                 2170                 2175             


Lys Glu  Thr Glu Gly His Val  Ile Cys Leu Cys Pro  Pro Gly Tyr 
    2180                 2185                 2190             


Thr Gly  Glu His Cys Asn Ile  Asp Gln Glu Val Cys  Glu Glu Gly 
    2195                 2200                 2205             


Trp Asn  Lys Tyr Gln Gly His  Cys Tyr Arg His Phe  Pro Asp Arg 
    2210                 2215                 2220             


Glu Thr  Trp Val Asp Ala Glu  Arg Arg Cys Arg Glu  Gln Gln Ser 
    2225                 2230                 2235             


His Leu  Ser Ser Ile Val Thr  Pro Glu Glu Gln Glu  Phe Val Asn 
    2240                 2245                 2250             


Asn Asn  Ala Gln Asp Tyr Gln  Trp Ile Gly Leu Asn  Asp Arg Thr 
    2255                 2260                 2265             


Ile Glu  Gly Asp Phe Arg Trp  Ser Asp Gly His Pro  Met Gln Phe 
    2270                 2275                 2280             


Glu Asn  Trp Arg Pro Asn Gln  Pro Asp Asn Phe Phe  Ala Ala Gly 
    2285                 2290                 2295             


Glu Asp  Cys Val Val Met Ile  Trp His Glu Lys Gly  Glu Trp Asn 
    2300                 2305                 2310             


Asp Val  Pro Cys Asn Tyr His  Leu Pro Phe Thr Cys  Lys Lys Gly 
    2315                 2320                 2325             


Thr Val  Ala Cys Gly Glu Pro  Pro Val Val Glu His  Ala Arg Thr 
    2330                 2335                 2340             


Phe Gly  Gln Lys Lys Asp Arg  Tyr Glu Ile Asn Ser  Leu Val Arg 
    2345                 2350                 2355             


Tyr Gln  Cys Thr Glu Gly Phe  Val Gln Arg His Met  Pro Thr Ile 
    2360                 2365                 2370             


Arg Cys  Gln Pro Ser Gly His  Trp Glu Glu Pro Arg  Ile Thr Cys 
    2375                 2380                 2385             


Thr Asp  Ala Thr Thr Tyr Lys  Arg Arg Leu Gln Lys  Arg Ser Ser 
    2390                 2395                 2400             


Arg His  Pro Arg Arg Ser Arg  Pro Ser Thr Ala His  
    2405                 2410                 2415 


<210>  425
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  425

Ala Val Leu Pro Gln Glu Glu Glu Gly Ser Gly Gly Gly Gln Leu Val 
1               5                   10                  15      


Thr Glu Val Thr Lys Lys Glu Asp Ser Cys Gln Leu Gly Tyr Ser Ala 
            20                  25                  30          


Gly Pro Cys Met Gly Met Thr Ser Arg Tyr Phe Tyr Asn Gly Thr Ser 
        35                  40                  45              


Met Ala Cys Glu Thr Phe Gln Tyr Gly Gly Cys Met Gly Asn Gly Asn 
    50                  55                  60                  


Asn Phe Val Thr Glu Lys Glu Cys Leu Gln Thr Cys Arg Thr Val Ala 
65                  70                  75                  80  


Ala Cys Asn Leu Pro Ile Val Arg Gly Pro Cys Arg Ala Phe Ile Gln 
                85                  90                  95      


Leu Trp Ala Phe Asp Ala Val Lys Gly Lys Cys Val Leu Phe Pro Tyr 
            100                 105                 110         


Gly Gly Cys Gln Gly Asn Gly Asn Lys Phe Tyr Ser Glu Lys Glu Cys 
        115                 120                 125             


Arg Glu Tyr Cys Gly Val Pro Gly Asp Gly Asp Glu Glu Leu Leu 
    130                 135                 140             


<210>  426
<211>  168
<212>  PRT
<213>  Glycine max

<400>  426

Met Pro Ser Thr Trp Gly Ala Ala Gly Gly Gly Leu Lys Leu Gly Arg 
1               5                   10                  15      


Thr Gly Asn Ser Asn Cys Pro Val Thr Val Leu Gln Asp Tyr Ser Glu 
            20                  25                  30          


Ile Phe Arg Gly Thr Pro Val Lys Phe Ser Ile Pro Gly Ile Ser Pro 
        35                  40                  45              


Gly Ile Ile Phe Thr Gly Thr Pro Leu Glu Ile Glu Phe Ala Glu Lys 
    50                  55                  60                  


Pro Tyr Cys Ala Glu Ser Ser Lys Trp Val Ala Phe Val Asp Asn Glu 
65                  70                  75                  80  


Ile Gln Lys Ala Cys Val Gly Ile Gly Gly Pro Glu Gly His Pro Gly 
                85                  90                  95      


Gln Gln Thr Phe Ser Gly Thr Phe Ser Ile Gln Lys Tyr Lys Phe Gly 
            100                 105                 110         


Tyr Lys Leu Val Phe Cys Ile Thr Gly Ser Gly Thr Cys Leu Asp Ile 
        115                 120                 125             


Gly Arg Phe Asp Ala Lys Asn Gly Glu Gly Gly Arg Arg Leu Asn Leu 
    130                 135                 140                 


Thr Glu His Glu Ala Phe Asp Ile Val Phe Ile Glu Ala Ser Lys Val 
145                 150                 155                 160 


Asp Gly Ile Ile Lys Ser Val Val 
                165             


