                         SEQUENCE LISTING

<110>  ISHWARAN, Hemant
       KALADY, Matthew
 
<120>  GENE SIGNATURE IS ASSOCIATED WITH EARLY STAGE RECTAL CANCER 
       RECURRENCE

<130>  44929223790

<150>  13/351,721
<151>  2012-01-17

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  3381
<212>  DNA
<213>  Homo sapiens

<400>  1
gcggccgcag cgcgcatttg ggctccgagg aagttgaccg aggcggctgc cgcaggatcc       60

cgggcccgga tcgcacgaag cccgcgcggc cgtctcctcc gcgcgccacc cctgcgcctc      120

ccgcgagctc cacttcccat ctgctattgt ttccgattgt tttccggtgg cgagcccggc      180

tccgaaactt acaaagtgtt ggatgtcccc cgttcgaact gagggactgc agaccgcctc      240

tgggtagctg gatgaagccc accccgtccc cttctggtac caaagtgctt actcctctcc      300

aaagtgccgt gtctgaactg ccgctgggaa gaagcggctc ctgagacgcg cccacacctt      360

tcacctgccg cgcgcttccc cctcctcggc caccttcccg gcggaagcag cgaggaggga      420

gccccctttg gccgtcctcc gtggaaccgg ttttccgagg ctggcaaaag ccgaggctgg      480

atttggggga ggaatattag actcggagga gtctgcgcgc ttttctcctc cccgcgcctc      540

ccggtcgccg cgggttcacc gctcagtccc cgcgctcgct ccgcacccca cccacttcct      600

gtgctcgccc ggggggcgtg tgccgtgcgg ctgccggagt tcggggaagt tgtggctgtc      660

gagaatgggg gtctgtgggt acctgttcct gccctggaag tgcctcgtgg tcgtgtctct      720

caggctgctg ttccttgtac ccacaggagt gcccgtgcgc agcggagatg ccaccttccc      780

caaagctatg gacaacgtga cggtccggca gggggagagc gccaccctca ggtgcactat      840

tgacaaccgg gtcacccggg tggcctggct aaaccgcagc accatcctct atgctgggaa      900

tgacaagtgg tgcctggatc ctcgcgtggt ccttctgagc aacacccaaa cgcagtacag      960

catcgagatc cagaacgtgg atgtgtatga cgagggccct tacacctgct cggtgcagac     1020

agacaaccac ccaaagacct ctagggtcca cctcattgtg caagtatctc ccaaaattgt     1080

agagatttct tcagatatct ccattaatga agggaacaat attagcctca cctgcatagc     1140

aactggtaga ccagagccta cggttacttg gagacacatc tctcccaaag cggttggctt     1200

tgtgagtgaa gacgaatact tggaaattca gggcatcacc agggagcagt caggggacta     1260

cgagtgcagt gcctccaatg acgtggccgc gcccgtggta cggagagtaa aggtcaccgt     1320

gaactatcca ccatacattt cagaagccaa gggtacaggt gtccccgtgg gacaaaaggg     1380

gacactgcag tgtgaagcct cagcagtccc ctcagcagaa ttccagtggt acaaggatga     1440

caaaagactg attgaaggaa agaaaggggt gaaagtggaa aacagacctt tcctctcaaa     1500

actcatcttc ttcaatgtct ctgaacatga ctatgggaac tacacttgcg tggcctccaa     1560

caagctgggc cacaccaatg ccagcatcat gctatttggt ccaggcgccg tcagcgaggt     1620

gagcaacggc acgtcgagga gggcaggctg cgtctggctg ctgcctcttc tggtcttgca     1680

cctgcttctc aaattttgat gtgagtgcca cttccccacc cgggaaaggc tgccgccacc     1740

accaccacca acacaacagc aatggcaaca ccgacagcaa ccaatcagat atatacaaat     1800

gaaattagaa gaaacacagc ctcatgggac agaaatttga gggaggggaa caaagaatac     1860

tttgggggga aaaaagtttt aaaaaagaaa ttgaaaattg ccttgcagat atttaggtac     1920

aatggagttt tcttttccca aacgggaaga acacagcaca cccggcttgg acccactgca     1980

agctgcatcg tgcaacctct ttggtgccag tgtgggcaag ggctcagcct ctctgcccac     2040

agagtgcccc cacgtggaac attctggagc tggccatccc aaattcaatc agtccataga     2100

gacgaacaga atgagacctt ccggcccaag cgtggcgctg cgggcacttt ggtagactgt     2160

gccaccacgg cgtgtgttgt gaaacgtgaa ataaaaagag caagaaagaa aaaggaaaca     2220

aaataagacc gtctgacagc aacaacggtc ccacaaacaa gtcacaaaag ataccgttaa     2280

actttttttt ttttttatca ttttactaca tgaacatcat ggataacaag ggattctgat     2340

tcattattaa tttcattaat tatattttct gatatgagtc tagaacttac tgcaaaaaca     2400

agacaaaact aaaaaaatac aactgagaag ggtgaagaga agtatgtttg ttaaacagta     2460

aaaatgaata gtatacttct taactaggtt tacaactggt ggaccacaca ccaggcacta     2520

atcacctggt gaggatttgg catatccacc aaaaaatgca tccgatttaa ccaacatctc     2580

caccagcgct acggactcct cccaattctg acatctcttg cagacaatac tatgctctct     2640

acacactgtt tagaaatgga aaggtgatct gcactgtatc ttgggtttgt tggctatgct     2700

tcctttgatg acatatatta tacagtatat atatacatat attttttttg ttagagttct     2760

agccatttta tttctccgca gggtcctttc tcagacatta ctgcatgctg tatatggcgt     2820

tagctgtgtg ttgatcttct aaaagatgat agagtttact ggtaattgtg taatcagctc     2880

ctgccttttt attttcttgg gttatttaca tgtcagagac atttataaaa agtgaaagga     2940

taaaaaaaaa aaaaaacaac taataccggg cgcagcatct ttccaggtgt ggctctgcgc     3000

taggccaccc caggtggccc cgctttctcc attctgccct gtggcgttaa cagacagcaa     3060

gcagctgaac aagcagtacc gtcagtaccc acttgcttta gcccattatg ggaatctctg     3120

atgcctttgt gaccactgga gagtttaatc ctcttggttt attttatttc ccacctttgt     3180

gtgagtgtgt atgaaagaga agaaaatgca atttttaggt aatctttttt ttttttcccc     3240

tcccctgaaa gtctgggaac ctgagagtcc tcggggaggg gtcctggatg tgatgaggga     3300

aagggggatt gggggatccg ggagggtggg gttgtctctg acttgacatt aaaaagtgtt     3360

ccatgtccct cttcaaaaaa a                                               3381


<210>  2
<211>  2980
<212>  DNA
<213>  Homo sapiens

<400>  2
cgcaggcagc ggctgggagc gcagcggcag cggcggcagc agaagctcgg ctcagcggct       60

gggggtggcc gctcgaatct gccagggcac ctcgctccct cgcctctggc agcgggaccc      120

tgtgggcatt gaaatccaac tcactcatgc ttatttcctg taatggacaa acttgatgct      180

aatgtgagtt ctgaggaggg tttcgggtca gtggagaagg tggtgctgct cacgtttctc      240

tcgacggtta tcctgatggc catcttgggg aacctgctgg tgatggtggc tgtgtgctgg      300

gacaggcagc tcaggaaaat aaaaacaaat tatttcattg tatctcttgc ttttgcggat      360

ctgctggttt cggtgctggt gatgcccttt ggtgccattg agctggttca agacatctgg      420

atttatgggg aggtgttttg tcttgttcgg acatctctgg acgtcctgct cacaacggca      480

tcgatttttc acctgtgctg catttctctg gataggtatt acgccatctg ctgccagcct      540

ttggtctata ggaacaagat gacccctctg cgcatcgcat taatgctggg aggctgctgg      600

gtcatcccca cgtttatttc ttttctccct ataatgcaag gctggaataa cattggcata      660

attgatttga tagaaaagag gaagttcaac cagaactcta actctacgta ctgtgtcttc      720

atggtcaaca agccctacgc catcacctgc tctgtggtgg ccttctacat cccatttctc      780

ctcatggtgc tggcctatta ccgcatctat gtcacagcta aggagcatgc ccatcagatc      840

cagatgttac aacgggcagg agcctcctcc gagagcaggc ctcagtcggc agaccagcat      900

agcactcatc gcatgaggac agagaccaaa gcagccaaga ccctgtgcat catcatgggt      960

tgcttctgcc tctgctgggc accattcttt gtcaccaata ttgtggatcc tttcatagac     1020

tacactgtcc ctgggcaggt gtggactgct ttcctctggc tcggctatat caattccggg     1080

ttgaaccctt ttctctacgc cttcttgaat aagtctttta gacgtgcctt cctcatcatc     1140

ctctgctgtg atgatgagcg ctaccgaaga ccttccattc tgggccagac tgtcccttgt     1200

tcaaccacaa ccattaatgg atccacacat gtactaaggg atgcagtgga gtgtggtggc     1260

cagtgggaga gtcagtgtca cccgccagca acttctcctt tggtggctgc tcagcccagt     1320

gacacttagg cccctgggac aatgacccag aagacagcca tgcctccgaa agagggccag     1380

gtcctaagct gctgcttgtg cgcgactgca cccggtattc tcttcacctg aggctttccg     1440

tccgccagtg caggaacccg gtgctcgctg ggcttttcct ctgagattcc agcaggtggc     1500

gctggaggga gtcaggggac ataatggcct ccttgttcac tttttatttc ccaacactcc     1560

ctcttcccag attctctgct tttgccgcgt ggtctctggt gtctctgaca tgttcccgtc     1620

actcactgtg tctgatctgt ctcactcacg ttctaagcac gatagcttgc tgcgtcctat     1680

ctcggtcact gatgtctcca aatacgcctt ctttgctgtg tgggcttcca gatatcaaca     1740

aaatactccc tctctgttcc tgtcttagcc agaggcgtcg ctcctgtctt gcttacttgc     1800

ttggtcacgt ccgtcacagc catgttcaag ctatcccctg cctcttcttc gccctgttct     1860

gtgccagacg ctaacacact tttctccctg tgtctgggtc caaacgtgca tcctcttggt     1920

tggccccctt gtcagtccca gacgtccact tgctcttcct tatgtccaat gtctgtcctc     1980

ctcttcagga catgctccat ttattttcca tggaagacac agggtcagag atctgtcaga     2040

ggaaaatggt ctccacagca actctggagg gaagctgaag acagatagct tcctcctggt     2100

gtcctggccg ctggcgtgtc tgccctgaga tgctcgctct cctgctgggc tagaacggga     2160

cgtcttctaa aaagccttgg gcagggctag caacatcgta ggtgtttatt aggcttcagg     2220

atctttccca tgaacttgtg atatcatttt gaaacccttc aatctggctt tgttgctgcc     2280

aaaggagata actgttggaa gttcacactg gggaaactca ttttcccctg cagctccccc     2340

aaggtgcagg agggcaggat ccagcagcac tggggatgcc gaggcaatgc tgtacttgaa     2400

gccagaggac ccaaattgcc gccctggctg tgctgcaaac aagctgtgag atcttgaata     2460

gtgttctttc atctctggac cccactttcc acatctgtgc actcaagctt ggactagagg     2520

acctttaagt tttctttctg tttctaagac aacagtatgc tgctatagcc gtctgctacc     2580

tcgagaagcc atggcctgcc tgccttttgg ctttgtttca aaggaacgac cctcctcatt     2640

tgggcctttt agacccctga cctttccagc tttgtccttc agattaatct ggatgtcttt     2700

tattcaaagc tgagtcagtg gctcttgcga atgccccata gcagaagtcc cgggaaggta     2760

aatgccaaac ccagagccat gtgagattct gactttgatc ttggctgtgg tttaatagca     2820

tctcaggatt atttatcata ttctcttttt ttcttattgc ttataaggtg tcagttattg     2880

tttccattgt tgtttacttt agttctggaa ctgaaaccga caggaagaaa ctttggaata     2940

aggaagagaa gattgaccaa accatccaaa tgccaaaaag                           2980


<210>  3
<211>  1768
<212>  DNA
<213>  Homo sapiens

<400>  3
tataaattcc ctcccttcgc tccttccccg gaacagcggc ctctgacacc agcacagcaa       60

acccgccggg atcaaagtgt accagtcggc agcatggcta cgaaatgtgg gaattgtgga      120

cccggctact ccacccctct ggaggccatg aaaggaccca gggaagagat cgtctacctg      180

ccctgcattt accgaaacac aggcactgag gccccagatt atctggccac tgtggatgtt      240

gaccccaagt ctccccagta ttgccaggtc atccaccggc tgcccatgcc caacctgaag      300

gacgagctgc atcactcagg atggaacacc tgcagcagct gcttcggtga tagcaccaag      360

tcgcgcacca agctggtgct gcccagtctc atctcctctc gcatctatgt ggtggacgtg      420

ggctctgagc cccgggcccc aaagctgcac aaggtcattg agcccaagga catccatgcc      480

aagtgcgaac tggcctttct ccacaccagc cactgcctgg ccagcgggga agtgatgatc      540

agctccctgg gagacgtcaa gggcaatggc aaagggggtt ttgtgctgct ggatggggag      600

acgttcgagg tgaaggggac atgggagaga cctgggggtg ctgcaccgtt gggctatgac      660

ttctggtacc agcctcgaca caatgtcatg atcagcactg agtgggcagc tcccaatgtc      720

ttacgagatg gcttcaaccc cgctgatgtg gaggctggac tgtacgggag ccacttatat      780

gtatgggact ggcagcgcca tgagattgtg cagaccctgt ctctaaaaga tgggcttatt      840

cccttggaga tccgcttcct gcacaaccca gacgctgccc aaggctttgt gggctgcgca      900

ctcagctcca ccatccagcg cttctacaag aacgagggag gtacatggtc agtggagaag      960

gtgatccagg tgccccccaa gaaagtgaag ggctggctgc tgcccgaaat gccaggcctg     1020

atcaccgaca tcctgctctc cctggacgac cgcttcctct acttcagcaa ctggctgcat     1080

ggggacctga ggcagtatga catctctgac ccacagagac cccgcctcac aggacagctc     1140

ttcctcggag gcagcattgt taagggaggc cctgtgcaag tgctggagga cgaggaacta     1200

aagtcccagc cagagcccct agtggtcaag ggaaaacggg tggctggagg ccctcagatg     1260

atccagctca gcctggatgg gaagcgcctc tacatcacca cgtcgctgta cagtgcctgg     1320

gacaagcagt tttaccctga tctcatcagg gaaggctctg tgatgctgca ggttgatgta     1380

gacacagtaa aaggagggct gaagttgaac cccaacttcc tggtggactt cgggaaggag     1440

ccccttggcc cagcccttgc ccatgagctc cgctaccctg ggggcgattg tagctctgac     1500

atctggattt gaactccacc ctcatcaccc acactcccta ttttgggccc tcacttcctt     1560

ggggacctgg cttcattctg ctctctcttg gcacccgacc cttggcagca tgtaccacac     1620

agccaagctg agactgtggc aatgtgttga gtcatataca tttactgacc actgttgctt     1680

gttgctcact gtgctgcttt tccatgagct cttggaggca ccaagaaata aactcgtaac     1740

cctgtccttc agaaaaaaaa aaaaaaaa                                        1768


<210>  4
<211>  2894
<212>  DNA
<213>  Homo sapiens

<400>  4
atatggatgc acacagagcc tgtagacctg agtggatgga cactgcctct tagaactaga       60

acttagaact ttatcttgaa aatgtaccac tgttgcagaa gctcctcaca gagtatgtgt      120

caggcatttt taacctgcta aaggcaagaa gaagtgttca ccacatagtt gcaaaggtct      180

tcaacttgcc acagccaaca gaaaaatcaa aatgattgaa ccctttggga atcagtatat      240

tgtggccagg ccagtgtatt ctacaaatgc ttttgaggaa aatcataaaa agacaggaag      300

acatcataag acatttctgg atcatctcaa agtgtgttgt agctgttccc cacaaaaggc      360

caagagaatt gtcctctctt tgttccccat agcatcttgg ttgccagcat accggcttaa      420

agaatggttg ctcagtgata ttgtttctgg tatcagcaca gggattgtgg ccgtactaca      480

aggtttagca tttgctctgc tggtcgacat tcccccagtc tatgggttgt atgcatcctt      540

tttcccagcc ataatctacc ttttcttcgg cacttccaga cacatatccg tgggtccgtt      600

tccgattctg agtatgatgg tgggactagc agtttcagga gcagtttcaa aagcagtccc      660

agatcgcaat gcaactactt tgggattgcc taacaactcg aataattctt cactactgga      720

tgacgagagg gtgagggtgg cggcggcggc atcagtcaca gtgctttctg gaatcatcca      780

gttggctttt gggattctgc ggattggatt tgtagtgata tacctgtctg agtccctcat      840

cagtggcttc actactgctg ctgctgttca tgttttggtt tcccaactca aattcatttt      900

tcagttgaca gtcccgtcac acactgatcc agtttcaatt ttcaaagtac tatactctgt      960

attctcacaa atagagaaga ctaatattgc agacctggtg acagctctga ttgtcctttt     1020

ggttgtatcc attgttaaag aaataaatca gcgcttcaaa gacaaacttc cagtgcccat     1080

tccaatcgaa ttcattatga ccgtgattgc agcaggtgta tcctacggct gtgactttaa     1140

aaacaggttt aaagtggctg tggttgggga catgaatcct ggatttcagc cccctattac     1200

acctgacgtg gagactttcc aaaacaccgt aggagattgc ttcggcatcg caatggttgc     1260

atttgcagtg gccttttcag ttgccagcgt ctattccctc aaatacgatt atccacttga     1320

tggcaatcag gagttaatag ccttgggact gggtaacata gtctgtggag tattcagagg     1380

atttgctggg agtactgccc tctccagatc agcagttcag gagagcacag gaggcaaaac     1440

acagattgct gggcttattg gtgccatcat cgtgctgatt gtcgttctag ccattggatt     1500

tctcctggcg cctctacaaa agtccgtcct ggcagcttta gcattgggaa acttaaaggg     1560

aatgctgatg cagtttgctg aaataggcag attgtggcga aaggacaaat atgattgttt     1620

aatttggatc atgaccttca tcttcaccat tgtcctggga ctcgggttag gcctggcagc     1680

tagtgtggca tttcaactgc taaccatcgt gttcaggacc caatttccaa aatgcagcac     1740

gctggctaat attggaagaa ccaacatcta taagaataaa aaagattatt atgatatgta     1800

tgagccagaa ggagtgaaaa ttttcagatg tccatctcct atctactttg caaacattgg     1860

tttctttagg cggaaactta tcgatgctgt tggctttagt ccacttcgaa ttctacgcaa     1920

gcgcaacaaa gctttgagga aaatccgaaa actgcagaag caaggcttgc tacaagtgac     1980

accaaaagga tttatatgta ctgttgacac cataaaagat tctgacgaag agctggacaa     2040

caatcagata gaagtactgg accagccaat caataccaca gacctgcctt tccacattga     2100

ctggaatgat gatcttcctc tcaacattga ggtccccaaa atcagcctcc acagcctcat     2160

tcttgacttt tcagcagtgt cctttcttga tgtttcttca gtgaggggcc ttaaatcgat     2220

tttgcaagaa tttatcagga tcaaggtaga tgtgtatatc gttggaactg atgatgactt     2280

cattgagaag cttaaccggt atgaattttt tgatggtgaa gtgaaaagct caatattttt     2340

cttaacaatc catgatgctg ttttgcatat tttgatgaag aaagattaca gtacttcaaa     2400

gtttaatccc agtcaggaaa aagatggaaa aattgatttt accataaata caaatggagg     2460

attacgtaat cgggtatatg aggtgccagt tgaaacaaaa ttctaatcaa catataattc     2520

agaaggatct tcatctgact atgacataaa aacaacttta tacccagaaa gttattgata     2580

agttcataca ttgtacgaag agtatttttg acagaatatg tttcaaactt tggaacaaga     2640

tggttctagc atggcatatt tttcacatat ctagtatgaa attatataag tattctaaat     2700

tttatatctt gtagctttat caaagggtga aaattatttt gttcatacat atttttgtag     2760

cactgacaga tttccatcct agtcactacc ttcatgcata ggtttagcag tatagtggcg     2820

ccactgtttt gaatctcata atttatacag gtcatattaa tatatttcca ttaaaaaatc     2880

agttgtacag tgga                                                       2894


<210>  5
<211>  2354
<212>  DNA
<213>  Homo sapiens

<400>  5
tttttttccc ctgctctccc aggggccaga caccaccgcc ccacccctca cgccccacct       60

ccctggggga tcctttccgc cccagccctg aaagcgttaa ccctggagct ttctgcacac      120

cccccgaccg ctcccgccca agcttcctaa aaaagaaagg tgcaaagttt ggtccaggat      180

agaaaaatga ctgatcaaag gcaggcgata cttcctgttg ccgggacgct atatataacg      240

tgatgagcgc acgggctgcg gagacgcacc ggagcgctcg cccagccgcc gcctccaagc      300

ccctgaggtt tccggggacc acaatgaaca acttgctgtg ctgcgcgctc gtgtttctgg      360

acatctccat taagtggacc acccaggaaa cgtttcctcc aaagtacctt cattatgacg      420

aagaaacctc tcatcagctg ttgtgtgaca aatgtcctcc tggtacctac ctaaaacaac      480

actgtacagc aaagtggaag accgtgtgcg ccccttgccc tgaccactac tacacagaca      540

gctggcacac cagtgacgag tgtctatact gcagccccgt gtgcaaggag ctgcagtacg      600

tcaagcagga gtgcaatcgc acccacaacc gcgtgtgcga atgcaaggaa gggcgctacc      660

ttgagataga gttctgcttg aaacatagga gctgccctcc tggatttgga gtggtgcaag      720

ctggaacccc agagcgaaat acagtttgca aaagatgtcc agatgggttc ttctcaaatg      780

agacgtcatc taaagcaccc tgtagaaaac acacaaattg cagtgtcttt ggtctcctgc      840

taactcagaa aggaaatgca acacacgaca acatatgttc cggaaacagt gaatcaactc      900

aaaaatgtgg aatagatgtt accctgtgtg aggaggcatt cttcaggttt gctgttccta      960

caaagtttac gcctaactgg cttagtgtct tggtagacaa tttgcctggc accaaagtaa     1020

acgcagagag tgtagagagg ataaaacggc aacacagctc acaagaacag actttccagc     1080

tgctgaagtt atggaaacat caaaacaaag accaagatat agtcaagaag atcatccaag     1140

atattgacct ctgtgaaaac agcgtgcagc ggcacattgg acatgctaac ctcaccttcg     1200

agcagcttcg tagcttgatg gaaagcttac cgggaaagaa agtgggagca gaagacattg     1260

aaaaaacaat aaaggcatgc aaacccagtg accagatcct gaagctgctc agtttgtggc     1320

gaataaaaaa tggcgaccaa gacaccttga agggcctaat gcacgcacta aagcactcaa     1380

agacgtacca ctttcccaaa actgtcactc agagtctaaa gaagaccatc aggttccttc     1440

acagcttcac aatgtacaaa ttgtatcaga agttattttt agaaatgata ggtaaccagg     1500

tccaatcagt aaaaataagc tgcttataac tggaaatggc cattgagctg tttcctcaca     1560

attggcgaga tcccatggat gagtaaactg tttctcaggc acttgaggct ttcagtgata     1620

tctttctcat taccagtgac taattttgcc acagggtact aaaagaaact atgatgtgga     1680

gaaaggacta acatctcctc caataaaccc caaatggtta atccaactgt cagatctgga     1740

tcgttatcta ctgactatat tttcccttat tactgcttgc agtaattcaa ctggaaatta     1800

aaaaaaaaaa actagactcc attgtgcctt actaaatatg ggaatgtcta acttaaatag     1860

ctttgagatt tcagctatgc tagaggcttt tattagaaag ccatattttt ttctgtaaaa     1920

gttactaata tatctgtaac actattacag tattgctatt tatattcatt cagatataag     1980

atttgtacat attatcatcc tataaagaaa cggtatgact taattttaga aagaaaatta     2040

tattctgttt attatgacaa atgaaagaga aaatatatat ttttaatgga aagtttgtag     2100

catttttcta ataggtactg ccatattttt ctgtgtggag tatttttata attttatctg     2160

tataagctgt aatatcattt tatagaaaat gcattattta gtcaattgtt taatgttgga     2220

aaacatatga aatataaatt atctgaatat tagatgctct gagaaattga atgtacctta     2280

tttaaaagat tttatggttt tataactata taaatgacat tattaaagtt ttcaaattat     2340

tttttaaaaa aaaa                                                       2354


<210>  6
<211>  4841
<212>  DNA
<213>  Homo sapiens

<400>  6
agcacatcgc tgcgggctca caaagcggcc agacgctcgg cggcggcgtg tggcaggagc       60

gcaggggcgc gagccggcga tcagccttcc cggcgaccgt gccgcgggag ctcgagcaac      120

tcggactagg ggacccgggc cggcccccaa gatgccggcg atcgcggtgt tggcggcggc      180

cgccgcggcg tggtgcttcc tccaagtcga gagccggcac ctggacgcgc tcgccggagg      240

cgcgggcccc aaccacggca atttcctaga caatgaccag tggctgagca ccgtctccca      300

gtacgaccgg gacaagtact ggaaccgctt tcgagacgat gattatttca gaaactggaa      360

tcccaacaag ccctttgacc aagccctgga cccatccaag gacccctgcc tgaaggtaaa      420

atgcagccct cacaaagtgt gtgtgaccca ggactaccag accgccctgt gtgtcagccg      480

caagcacctg ctccccaggc aaaagaaggg gaacgtggcc cagaaacact gggttggacc      540

ttcgaatttg gtcaagtgca agccctgtcc cgtggcacag tcagccatgg tctgcggctc      600

agatggccac tcctacacat ccaagtgcaa attggagttc catgcttgtt ctactggcaa      660

aagcctcgcc accctctgtg atgggccctg tccctgtctc ccagagcctg agccaccaaa      720

gcacaaggca gaaaggagtg cctgcacaga caaggagttg cggaaccttg cctcccggct      780

gaaggattgg tttggagctc tccacgagga tgcgaacaga gtcatcaagc ccaccagctc      840

caacacagcc caaggcaggt ttgacactag catcctgccc atctgcaagg actccctggg      900

ctggatgttc aacaagttgg acatgaacta tgacctcctg cttgaccctt cagagatcaa      960

tgccatctac ctggataagt acgagccctg tatcaagcct cttttcaact cgtgtgactc     1020

cttcaaggat ggcaagcttt ctaacaatga gtggtgctac tgcttccaga agcctggagg     1080

tctcccttgc cagaatgaaa tgaacagaat tcagaagctg agtaagggga aaagcctgtt     1140

gggggccttc atacctcggt gtaatgagga gggctattac aaagccacac agtgccacgg     1200

cagcacgggg cagtgctggt gtgtggacaa atatgggaat gagttggctg gctccaggaa     1260

acagggtgct gtgagctgtg aagaggagca ggaaacctca ggggattttg gcagtggtgg     1320

gtccgtggtc ctgctggatg acctagaata tgaacgggag ctgggaccaa aggacaaaga     1380

ggggaagctg agggtgcaca cccgagccgt gacagaggat gatgaggatg aggatgatga     1440

caaagaggat gaggtcgggt acatatggta gtgcccacaa gaaagaggac acaagttttg     1500

cacaaaattg caagtcactt cctattcctg catttgtatc taagactcca aggcaccaag     1560

gtctcttctc cattgttgct ctctataccc gacctaaggt ttggaagaca actgcttgtt     1620

cccagaggat tctgattttg catatgtttg tatgggagaa agggtgttgt gttttttttt     1680

tgttgttgtt tattttttgg atagggaagt cattggctta attagagcct ccttcctttc     1740

tgtgagattt ttccaacaag catgtgattt acgtggaatt ctgacagtgc agggagcccc     1800

aaccctctta aatgtcaaag accctttttg attacccaca ctggtggtta ttacagcatg     1860

gttcccagcc ttacagtgtc taagtgcttc tcttgtgtcc tgtagatgtt gtgaaaaaga     1920

aaaaaacaaa aaatacacca cactgtactt tttccccctg cccccgttac tgccggtgat     1980

tattattaaa aattagtttt tttcacatca ttatatctgg cttcctataa acaacagcct     2040

taattcagtc aagactccct ttggggaatt cattttatta aaaattggtg tctggatact     2100

tccctgtaca tgcataaata tgcatgcatg tacagaaaga ctgtatgtgt gtgccttgca     2160

cacacaccca tacctctcag aaaaagtgtt tgggtatctt aaaaactcga aaaacaatga     2220

taaatttctc agcttgtcca gacctggaac aaaatttctg gaataagaaa tttgtattaa     2280

agtccttttt tgcactaaca gttggctctt gtagcctgca ggctgaggaa gtctcttctc     2340

tgtgcatcag cagagttact gaaagcctct gattgagaaa aaacctccgt ctgcctaaat     2400

cacttttctc gcagaagcca tgcgactccc acacgacacg ggcagcttca caagccatct     2460

ctttcatttc tgcttgaagc cccttggctg cagcaatcct gtctgccata ggtttcttcc     2520

ttccttacct actcaagggc tttttctaag gcatgcacac atatctcctg ttctctgaga     2580

gtaccatggt gttccttaaa agaagaaaat ttctaattct gaactcaatg ttttgctttt     2640

actccctttc tactgacaaa tcatgataag ggcacaaaag ctgtacagat tttttttttt     2700

aaccactcaa tcccaaatgg aggcctacaa agaacatcgt aataacacat ggaagcaaac     2760

cctgggtttt taagagcaaa ttctgtcccc ccctcactcc cccaagtgac aagatactaa     2820

tgaagaaagt tcttcaccat agtgtttgtt ttaactaaac tcattggagt ctagttccaa     2880

atttggtagg gtcatcatct ctacattcct taggatttct ctccctatca agctggccca     2940

gatacaagta ccaaacagta gtctctgaag ttcccccatt tccttcagta ccagtctata     3000

agctactgtc cgccactgat tttcatttat cagggtgtcc taatcagaat cagccaccca     3060

agcaagcctc tctggcccac atatctatct cttgccttcc cccatgaact tcagcctgtc     3120

cacacaaaag ccacataaac tcaagcaaga aatatgttca gccaaaacat gattatagtg     3180

gcagctgacc aatcccccat cccaaattga ccatttagat gtaccaactc accttaaatt     3240

agcatgttcc aatccagtcg gcattgcctg aatacagtag catcatacct atagttggtc     3300

ttagataaga aatgaactac ttgatatagc aaagtccttt ggcttcgtaa ataaccctga     3360

ggttttgtac ttactttccc cataggaaga cagaccatag gcaaactctg ttttgggatc     3420

tcaactccat cacctttgtt tcaatatttt ttttctctct tgaacaaaac tgagataatt     3480

tagaaaacag gtgcttaatt gcaataaaat tactatgaag tatattaaaa atcacgacat     3540

tgtaaaatct cactttagat catcaaagaa aaccattgtt actatctcct ttgagcttag     3600

gaaaatgtac aagagaacaa attaaaattg aaaaattgat ttcacttaga aaaacttcta     3660

ggaacagggt gaaccactga ttttaatttg cctaattatc ttatgacaag tatcaaatta     3720

agatgacact taaagatcct tagcattaac ttaatgatgg agaagagtgc tcaatagaca     3780

gttcccagta aggtaatgag atgccatttt cagagacatt ctaagaagat attttgattc     3840

attaaaacat taaataaaaa gccctcctca gattggaacc cccaaatcga tggagccaca     3900

ttaataatac ttttcatgcc tcactttgac atgacagcat tcgatttttt taaagatctt     3960

taatactttc catgagtact aaagattgta atgagttacc ttatccttag aagtagaatg     4020

tttgctttct tcttcttgga aatagtcctc caaaaagtcc acttgtacca gtgacaagaa     4080

gtcacttgta tagtgaccaa gtacacataa aatactgatt ataaaaatat tgtaataaac     4140

cacttcctca tttgatacag gtattaagct gaatcctcac taattcactt ttgaaaagtt     4200

cttaatgaac agttttattc ttattccatg aacagctctt ttaatacaat ttccttggta     4260

tccaacttaa atcccagaat tttgttccac catggttagt tatttgccat atgaatgtat     4320

tcttgtttct accaatattc taggcatgag aataccttaa tactgagttg gagattttgt     4380

atctgtttct cctcctttac gcccattttc ctacccacag cagcaaatga caacgtgtct     4440

gtccaggtct gtccccctgc tcatcccagg atgccactca catttttttc ttcttgttac     4500

cttgaccacg ctgtacagta acatccaaga gcccattcta cagtgggtgg ttttggtctt     4560

tttataactt tttctcaaag tcactgatgt ttgttcctgt taaatgtata gcattgtaat     4620

gagagcccat caaatcctga gtgtcagttt gttgtcccta ttgtagatga aatagtgatg     4680

tagcaaaaac ctagtaaatt ctgaatgctt ttccacgtag acttatctgg aatgtgaaca     4740

caactctttg gttaatagta aatgcttaac tgtagtcctg agtaggtgca tttctgtctg     4800

tctcaataaa ttttactttg tctgcaaaaa aaaaaaaaaa a                         4841


<210>  7
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Val Asn Pro Thr Val Phe Phe Asp Ile Ala Val Asp Gly Glu Pro 
1               5                   10                  15      


Leu Gly Arg Val Ser Phe Glu Leu Phe Ala Asp Lys Val Pro Lys Thr 
            20                  25                  30          


Ala Glu Asn Phe Arg Ala Leu Ser Thr Gly Glu Lys Gly Phe Gly Tyr 
        35                  40                  45              


Lys Gly Ser Cys Phe His Arg Ile Ile Pro Gly Phe Met Cys Gln Gly 
    50                  55                  60                  


Gly Asp Phe Thr Arg His Asn Gly Thr Gly Gly Lys Ser Ile Tyr Gly 
65                  70                  75                  80  


Glu Lys Phe Glu Asp Glu Asn Phe Ile Leu Lys His Thr Gly Pro Gly 
                85                  90                  95      


Ile Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn Gly Ser Gln Phe 
            100                 105                 110         


Phe Ile Cys Thr Ala Lys Thr Glu Trp Leu Asp Gly Lys His Val Val 
        115                 120                 125             


Phe Gly Lys Val Lys Glu Gly Met Asn Ile Val Glu Ala Met Glu Arg 
    130                 135                 140                 


Phe Gly Ser Arg Asn Gly Lys Thr Ser Lys Lys Ile Thr Ile Ala Asp 
145                 150                 155                 160 


Cys Gly Gln Leu Glu 
                165 


<210>  8
<211>  6476
<212>  DNA
<213>  Homo sapiens

<400>  8
gaacgtggta taaaaggggc gggaggccag gctcgtgccg ttttgcagac gccaccgccg       60

aggaaaaccg tgtactatta gccatggtca accccaccgt gttcttcgac attgccgtcg      120

acggcgagcc cttgggccgc gtctcctttg aggtcgggcg ggcggcggcg tgcgggaatg      180

gggcccagaa agtgggccgg ggtcggggtg ggtggtagcg ccccaaaggc ccgggcgcgg      240

ggcgaccctg cttgaggggc gagcgcgggc gggctgcggc gccatttcct gacgaggggc      300

cattttggga ggtccgcgag tcgcggggag gaggccggga cggcggcgga caaaggcagg      360

cggggcggct gcgaggccgt tgggggaggg ggcccgcgtc cgcccgcccg cctcatgtgg      420

ccgcgccctg tcctgtccga cgcacgtgct cggcggccgc gctcaggtcc gcgccttgag      480

agtcgttggg ctccgcccta gcttggcctg ggcgccgcag accggagcca gaagcacgct      540

cgcgggggct tgcgaccgcc ttcctgggaa gctgtcccct ggcaggcatg ggtgctttac      600

atcctgagct gggaagctgt ttgcttgagg gtttttctca aggatcgagg cgcggtgtga      660

gcccgtccat gctcggtcct gtagatcccg ggaggccatg ttataaaagg agacttgctg      720

ggatgtgacg ggttgccact tgaaatatct tccatttgga taaagtagga atatttatac      780

atgtgcccca aacgtccctc cgtgtccccc acccccaagc ggaaatgtga aaatgggcct      840

tgcctttgct ggtgcccaag gaccgccttc cactgcagtg acggcgctgg cgggggaggc      900

gctcttgagc ccctcccgat tgtccctctg cctagcaagc aagttgcgac tggccacaag      960

gcaggcctct tccgaccaag gtggattacc agtgattacc taattagttt tgagagcgtt     1020

aaatgagttc ttaaagatca gttgtaatta tagcatagta tctaaacttg gcgcgtgtct     1080

tcaaagttaa atattgagta cgattccgtt ccagttaaca tggatagacc ttagggagta     1140

gcgaaatagg atgttagtgg ttttattcct ttaaatcaca tctcaaaagg ccaccaatgg     1200

ctagtttggg atcttattcc gaaaatagat tgatcctcat gcagtcttcg tgaggacaga     1260

gcgatttcct tgttgcctac cctgtccata gtgcctggca cataggcact gaaacactgc     1320

atgttaatcc acaccccacc ccacctatga gtgtagtcaa agctggtaag tgacaagggc     1380

tttcgtggaa acttggcctg acctaatgtt gggcatcagg ttacccaaag agcttcaggg     1440

aaatgagaaa ggacttgcag gtcttgatga gaatggaggg gtaactgcca atgagggctt     1500

tggctttagc gaaagtctga aagggaagcc ataggaactt aaacgtaccg actataaagc     1560

tctgagaaaa gctgatgttt tagaaagacc atacattcta ggtacaaata cctaaaaact     1620

aaaaaataag tacgttggcc aggcgggcgg atcacgaagt caggagattg agaccgtcct     1680

ggccaacatg gtgaaacccc acctctatta aaaatacaaa aattagctgg gcgtggtggc     1740

gcttgcctgt aatctcagct actctagagg ctgaggcagg agaatcgctt gaaccccgga     1800

ggcggaggct gcagtgagcc gagatcgtgc cactgcactc cagcctggtg acagtgagac     1860

tcttgtctca aaaaaaaaaa agtacattgc tataagagaa gtgcacacgg atactagtag     1920

ttaattcagt cacatctgtg aaatagctta taaaatgcta cttttaaaca agctgttttt     1980

atgaaagggc ttgtaaatgt ttatggtatt taagctacct ctctagccat aacgtattat     2040

acattcaaga aaggttcaaa accagatata ctagaaacca atctttattt tttaccccac     2100

tactaggtaa ggggcctgga taccaagaag tgactgctca tctaatccat aaagctatgt     2160

taacagattg gaggtagtag cattttcatt acaagtgact aaaagaacag ctgtttaccc     2220

ctgatcgtgc agcagtgctt gctgttcctt agaattttgc cttgtaagtt ctagctcaag     2280

ttggggggtg gtgatagaca tttaagaagc catatatctt ttcagaagta ggtgtgatgt     2340

actaaaagtt tgagacactt tctagaagtc tcactattta agttatgact agtattggat     2400

ttttggcatg tctttgggtt tcatgtttct taacccaact gcctgcaggg ccttatggct     2460

gtcaggagca gttcttggga attaaagtaa ttactgaaga agtattctag tgagaaaatg     2520

aatttatgac tcagaagccc ctaaagacat gggtactaag caacaaaata agcagatgtt     2580

aattaactgt aattttctct tacagctgtt tgcagacaag gtcccaaaga cagcaggttg     2640

gtccattttc taagtttaac aaagatgttc caattgtgac agtttgtgtg tgtgtgtgta     2700

tatatatatt tttatgtatg tatatatgtg tttaattttt ttttaaacag aaaattttcg     2760

tgctctgagc actggagaga aaggatttgg ttataagggt tcctgctttc acagaattat     2820

tccagggttt atgtgtcagg tacgaaattt actgaatttt attttatttg ggttgctccc     2880

ttcatttggg attgagccag aatatttcag gatacacata tctgaactgt tactctacca     2940

tttcggttct atttaaccct tctattcagt ttgaacttgg gtttaaagtt tgaaccttgc     3000

agatttggca cacttcatgg ttatgttgtc agaagtgaca tttttcctat atgttgacag     3060

ggtggtgact tcacacgcca taatggcact ggtggcaagt ccatctatgg ggagaaattt     3120

gaagatgaga acttcatcct aaagcatacg ggtcctggca tcttgtccat ggcaaatgct     3180

ggacccaaca caaatggttc ccagtttttc atctgcactg ccaagactga gtggtaaggg     3240

tacaacatgg cacactaacc acctgactaa atgaaaagtt gccctggggg gaacggaaca     3300

aacactactt ttcttcaacc tttgcttcca cagacttttt catccctaag atactagaag     3360

aagagcatac ataaacgaca aatatagcca atgtgataca gaatgtcaga tactatgata     3420

gaaacttggc ccttagctgg gtggttgaat taggtgctac ttttttgaga tggagttttg     3480

ctctgttgcc aggttggagt gcagtggcac aatctgggct cactgcaacc tctgcctcct     3540

gggttcaagc gattctcctg ccttggcctc ctgagtagct gagaatacag atgtgtgcca     3600

gcatgcctgg ctaatttttt gtatttttgt ggagacgggg tttcatcatg ttggccaagc     3660

tggtcttgaa ctcgtgactt aaggtgaacc acctgccttg gccccccaaa gtgctgggat     3720

ttcaggcatg agccactgcg cccaaccaat taagtgcttt tttttttttt ttcttttctc     3780

agactggatc tcgctcttat ctcccaggtt ggagtgcagt ggtgccatct cagctcactg     3840

caacctcctc ccgggttcaa gcaattcttc tgcctcagcc tctcaagtag ctggaactac     3900

aggcatgcac caccactccc agctaaattg tgtattatta gtagagcggg atttaccatg     3960

ttgtccaggc tggtctcgaa ctcctgggct caagtgatct gcctgccttg acccccccaa     4020

agtgctggga ttacaggcat gagccactgt gcccacccaa ttaagtgctg cttttatgtt     4080

actattaata acatgcggtt ggttgggttt tttgtttctt tggggttttt gttttgtttt     4140

gtttgttttt gggggagggg ggcgcaattc attctatatg tgtaactctt ttttgagatg     4200

gagtttcgct ctgtcgccca ggctggagtg cagtggcgcg atctcggctc actgcaagct     4260

ccgcctccca ggttcacgcc attctcctgc ctcagcctcc cgagtagctg ggactatagg     4320

cacacgccac catgcccggc taattttttg tatttttagt agagacaggg tttcaccgtg     4380

ttagccagga tggtctcgat ctcctgacct cgtgatccgc ccgccttggc ctcccaaagt     4440

gctgggatta caggcgtgag ccaccgcacc cggcctatat gtgtaactct ttaatggtaa     4500

ttggagaatc atgtttaatg acatttagta caaaaggctt cagttaaaaa aaaaaaaaaa     4560

agctaccttt ctcgtcttgg ttcatgacac atggaggctg cttgtttgtg gttgccagtc     4620

atagtgattg ttcttccttt tcaaggttgg atggcaagca tgtggtgttt ggcaaagtga     4680

aagaaggcat gaatattgtg gaggccatgg agcgctttgg gtccaggaat ggcaagacca     4740

gcaagaagat caccattgct gactgtggac aactcgaata agtttgactt gtgttttatc     4800

ttaaccacca gatcattcct tctgtagctc aggagagcac ccctccaccc catttgctcg     4860

cagtatccta gaatctttgt gctctcgctg cagttccctt tgggttccat gttttccttg     4920

ttccctccca tgcctagctg gattgcagag ttaagtttat gattatgaaa taaaaactaa     4980

ataacaattg tcctcgtttg agttaagagt gttgatgtag gctttatttt aagcagtaat     5040

gggttacttc tgaaacatca cttgtttgct taattctaca cagtacttag atttttttta     5100

ctttccagtc ccaggaagtg tcaatgtttg ttgagtggaa tattgaaaat gtaggcagca     5160

actgggcatg gtggctcact gtctgtaatg tattacctga ggcagaagac cacctgaggg     5220

taggagtcaa gatcagcctg ggcaacatag tgagacgctg tctctacaaa aaataattag     5280

cctggcctgg tggtgcatgc ctagtcctag ctgatctgga ggctgacgtg ggaggattgc     5340

ttgagcctag agtgagctat tatcatgcca ctgtacagcc tgggtgttca cagatcttgt     5400

gtctcaaagg taggcagagg caggaaaagc aaggagccag aattaagagg ttgggtcagt     5460

ctgcagtgag ttcatgcatt tagaggtgtt cttcaagatg actaatgtca aaaattgaga     5520

catctgttgc ggtttttttt tttttttttt cccctggaat gcagtggcgt gatctcagct     5580

cactgcagcc tccgcctcct gggttcaagt gattctagtg cctcagcctc ctgagtagct     5640

gggataatgg gcgtgtgcca ccatgcccag ctaatttttg tatttttagt atagatgggg     5700

tttcatcatt ttgaccaggc tggtctcaaa ctcttgacct cagctgatgc gcctgccttg     5760

gcctcccaaa ctgctgagat tacagatgtg agccaccgca ccctacctca ttttctgtaa     5820

caaagctaag cttgaacact gttgatgttc ttgagggaag catattgggc tttaggctgt     5880

aggtcaagtt tatacatctt aattatggtg gaattcctat gtagagtcta aaaagccagg     5940

tacttggtgc tacagtcagt ctccctgcag agggttaagg cgcagactac ctgcagtgag     6000

gaggtactgc ttgtagcata tagagcctct ccctagcttt ggttatggag gctttgaggt     6060

tttgcaaacc tgaccaattt aagccataag atctggtcaa agggataccc ttcccactaa     6120

ggacttggtt tctcaggaaa ttatatgtac agtgcttgct ggcagttaga tgtcaggaca     6180

atctaagctg agaaaacccc ttctctgccc accttaacag acctctaggg ttcttaaccc     6240

agcaatcaag tttgcctatc ctagaggtgg cggatttgat catttggtgt gttgggcaat     6300

ttttgtttta ctgtctggtt ccttctgcgt gaattaccac caccaccact tgtgcatctc     6360

agtcttgtgt gttgtctggt tacgtattcc ctgggtgata ccattcaatg tcttaatgta     6420

cttgtggctc agacctgagt gcaaggtgga aataaacatc aaacatcttt tcatta         6476


