                         SEQUENCE LISTING

<110>  Oslo universitetssykehus HF
       Falnes, Pal O.
       Kernstock, Jens S.N.
       Klungland, Arne
       Fusser, Markus
 
<120>  Methyltransferases and Uses Thereof

<130>  INVEN-32344/WO-1/ORD

<150>  US 61/586,880
<151>  2012-01-16

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  1784
<212>  DNA
<213>  Homo sapiens

<400>  1
gcgcgccgct ttctgttgcc gggcgcaatg gcggatacgc tggagtcctc gctggaggac       60

ccactgcgga gctttgtgcg agttttggag aagcgggatg gtacagtgct acgactacag      120

cagtatagct ccggtggcgt gggttgcgtt gtgtgggacg ctgccattgt cctttctaaa      180

tacctggaaa cgcccgagtt ttctggcgac ggggcccacg cgctgagccg gcggtcggtg      240

ctggagctgg gttcgggcac cggggccgtg gggctcatgg ctgctaccct cggggctgat      300

gttgtagtca ccgatcttga ggaattgcaa gacttgctga agatgaatat taatatgaac      360

aagcatcttg tcactggttc tgttcaagcc aaggtactga aatgggggga agaaatagaa      420

ggctttcctt ctccacccga cttcatactg atggccgact gcatatacta tgaagagtct      480

ttggagccat tgctgaaaac tctaaaagat atcagcggat ttgaaacttg tattatatgt      540

tgttatgaac aacgaacaat ggggaaaaat ccagaaattg agaaaaaata ttttgagctc      600

cttcagctag attttgactt tgaaaaaatt cctttggaaa aacatgatga agagtatcga      660

agtgaagata ttcatattat atacatcaga aagaaaaaat cgaaatttcc atcgtgaagc      720

ctttaatcat cttacccaag gctctaacaa cctgggtaaa ctaaagatgt gaatagagca      780

tgtgaataca gcatgggaag attgtgttca cagatttttt tttccggcac gtccttagag      840

atccgatgta tagatgatga ccaccagggg ctgtctgcaa tacgaaaaat tcctgcttgc      900

ctgcctgcct gccaatggcc ctgaatccag cttaggttac ttagttcagc atcaagttct      960

tcttaaatgt tgggaatcag ttattcaaat aaaaattggt attgaggcga ggctgaaatc     1020

tgccaaaaac agccaacatg atttgactgg accttttaca ggaagctaga gataaatttc     1080

tgaagagaac tatctgctat tatataataa tgttttaaat tcaaactagt aaattttagt     1140

ttgtcttcag agtttaaaag gttttcattt tgtacataat tatacaatat ttatcatttg     1200

tattttccac ttcatttctt ttaaaatatc tttaatactg aaatgttctt ttaattttaa     1260

aaagaactga gatattgtct tgtatactta tattagccaa agttttcttt tcctccacca     1320

tacatatcta tgtgatttaa tcagtaaatt gtactgtaat gagttgctaa gaagacaaat     1380

cagaagattg gaggaacaaa agatatcttt acagattttt catttgagca tggagtgaga     1440

atagaaagac cagtttcagg cttatgcact tacgtggctc atgcacttta tgtatatgtt     1500

ccaggaaaat ctggcttaaa aatactggta ttgtttacat gaagcagtga aaggtttttg     1560

aataactaca aatgtagttc tatatgtata taccaaatga atttctgttc tgtgtctctc     1620

tgttttatgt tatgaagcca ttcgctcata tacaataatc tgtcaaggac tttaatcata     1680

cttgttccaa agagtagtaa ccggatggaa ttctggtatt tataggcatt ggtgctagat     1740

ggtacatttt atgtgttaaa ataaacattg tttttgagac cttg                      1784


<210>  2
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Asp Thr Leu Glu Ser Ser Leu Glu Asp Pro Leu Arg Ser Phe 
1               5                   10                  15      


Val Arg Val Leu Glu Lys Arg Asp Gly Thr Val Leu Arg Leu Gln Gln 
            20                  25                  30          


Tyr Ser Ser Gly Gly Val Gly Cys Val Val Trp Asp Ala Ala Ile Val 
        35                  40                  45              


Leu Ser Lys Tyr Leu Glu Thr Pro Glu Phe Ser Gly Asp Gly Ala His 
    50                  55                  60                  


Ala Leu Ser Arg Arg Ser Val Leu Glu Leu Gly Ser Gly Thr Gly Ala 
65                  70                  75                  80  


Val Gly Leu Met Ala Ala Thr Leu Gly Ala Asp Val Val Val Thr Asp 
                85                  90                  95      


Leu Glu Glu Leu Gln Asp Leu Leu Lys Met Asn Ile Asn Met Asn Lys 
            100                 105                 110         


His Leu Val Thr Gly Ser Val Gln Ala Lys Val Leu Lys Trp Gly Glu 
        115                 120                 125             


Glu Ile Glu Gly Phe Pro Ser Pro Pro Asp Phe Ile Leu Met Ala Asp 
    130                 135                 140                 


Cys Ile Tyr Tyr Glu Glu Ser Leu Glu Pro Leu Leu Lys Thr Leu Lys 
145                 150                 155                 160 


Asp Ile Ser Gly Phe Glu Thr Cys Ile Ile Cys Cys Tyr Glu Gln Arg 
                165                 170                 175     


Thr Met Gly Lys Asn Pro Glu Ile Glu Lys Lys Tyr Phe Glu Leu Leu 
            180                 185                 190         


Gln Leu Asp Phe Asp Phe Glu Lys Ile Pro Leu Glu Lys His Asp Glu 
        195                 200                 205             


Glu Tyr Arg Ser Glu Asp Ile His Ile Ile Tyr Ile Arg Lys Lys Lys 
    210                 215                 220                 


Ser Lys Phe Pro Ser 
225                 


<210>  3
<211>  212
<212>  PRT
<213>  Acyrthosiphon pisum

<400>  3

Met Asp Thr Asn Ala Tyr Tyr Arg Asn Phe Asp Leu Glu Ser Val Asn 
1               5                   10                  15      


Val Thr Leu Arg Phe Cys Gln His Glu Tyr Gly Asp Val Asn Cys Val 
            20                  25                  30          


Val Trp Asp Ala Ser Leu Val Leu Ala Lys Tyr Leu Glu Thr Leu Phe 
        35                  40                  45              


Leu Lys Asn Asn Glu Thr Phe Lys Ser Lys Arg Val Ile Glu Leu Gly 
    50                  55                  60                  


Ser Gly Leu Gly Cys Val Gly Leu Ala Ala Ala Cys Phe Gly Ala Asn 
65                  70                  75                  80  


Val Lys Leu Thr Asp Leu Pro Glu Asn Leu Pro Gln Leu Lys Gln Asn 
                85                  90                  95      


Val Asp Glu Asn Thr Pro Trp Leu Lys Gly Cys Val Glu Thr Val Ala 
            100                 105                 110         


Leu Thr Trp Gly Thr Thr Phe Glu Ser Glu Pro Phe Asp Phe Val Leu 
        115                 120                 125             


Met Ala Asp Cys Ile Tyr Tyr Pro Glu Val Val Glu Glu Leu Val Lys 
    130                 135                 140                 


Thr Ile Thr Glu Leu Thr Thr Pro Lys Thr Val Leu Leu Ile Ser Gln 
145                 150                 155                 160 


Glu Leu Arg Glu Thr Glu Lys Gln Lys Asn Thr Trp Lys Met Phe Leu 
                165                 170                 175     


Ser Leu Leu Leu Glu His Phe Glu Val Ser Tyr Val Pro Glu Glu Glu 
            180                 185                 190         


Gln His Pro Ile Phe Ser Ser Ser Asp Ile Ile Leu Ile Asn Ala Lys 
        195                 200                 205             


Lys Lys Cys Leu 
    210         


<210>  4
<211>  206
<212>  PRT
<213>  Caenorhabditis elegans

<400>  4

Met Ala Glu Ser Glu Glu Tyr Ala Arg Val Ile Ser Phe Asn Asn Asp 
1               5                   10                  15      


His Asp Glu Leu Ile Ile Tyr Gln Glu Thr Val Thr Asp Val Gly Gly 
            20                  25                  30          


Val Ile Trp Asp Ser Ala Leu Met Thr Ile His Tyr Phe Phe Lys Tyr 
        35                  40                  45              


Pro Lys Pro Phe Glu Gly Lys Lys Val Leu Glu Leu Gly Ser Gly Thr 
    50                  55                  60                  


Gly Val Gly Gly Ile Ala Leu Ala Ala Leu Gly Ala Asp Val Ile Ile 
65                  70                  75                  80  


Thr Asp Leu Pro Glu Arg Leu Ala Leu Ile Glu Lys Asn Val Glu Ala 
                85                  90                  95      


Asn Arg Lys Leu Thr Gly Asn Arg Ile Lys Val Gln Val Leu Asp Trp 
            100                 105                 110         


Thr Lys Asp Arg Ile Pro Glu Gly Leu Asp Met Val Leu Ala Ile Asp 
        115                 120                 125             


Cys Val Tyr Tyr Asn Ser Thr Ile Asp Pro Leu Ile Thr Leu Leu Asn 
    130                 135                 140                 


Asp Cys Asp Ala Lys Glu Ile Met Val Val Ser Glu Glu Arg Asp Ile 
145                 150                 155                 160 


Gly Glu Ala His Leu Ala Gln Lys Ser Phe Phe Lys Asp Ile Gln Lys 
                165                 170                 175     


Phe Phe Arg Leu Glu Leu Ile Pro Gln Lys Glu Leu Asp Glu Asp Tyr 
            180                 185                 190         


Cys Ala Asp Asp Ile Ile Ile Gly Lys Leu Ile Arg Asn Val 
        195                 200                 205     


<210>  5
<211>  225
<212>  PRT
<213>  Nematostella vectensis

<400>  5

Met Ala Asp Asp Asn Lys Ile Ala Ala Val Asp Met Thr Asn Leu Phe 
1               5                   10                  15      


Thr Arg Glu Leu Glu Gly Asn Tyr Gly Asn Leu Val Ile Lys Gln Ala 
            20                  25                  30          


Val Ser Gly Asp Val Gly Cys Val Val Trp Asp Ala Ala Ile Val Leu 
        35                  40                  45              


Ala Lys Tyr Leu Glu Thr Asp Gly Phe Asn Val Asn Tyr Gly Leu Ala 
    50                  55                  60                  


Lys Lys Arg Ala Val Glu Leu Gly Ala Gly Thr Gly Val Val Gly Leu 
65                  70                  75                  80  


Ala Ala Ala Ala Met Gly Ala Asp Val Val Gly Thr Asp Leu Glu Asp 
                85                  90                  95      


Phe Ile Pro Leu Ile Asp Leu Asn Lys Arg Thr Asn Gly His Leu Ile 
            100                 105                 110         


Thr Gly Lys Phe Ser Ala Arg Cys Leu Lys Trp Gly Ser Asp Val Ser 
        115                 120                 125             


Ser Phe Leu Pro His Pro Asp Tyr Val Phe Ile Ala Asp Cys Ile Tyr 
    130                 135                 140                 


Tyr Glu Glu Ser Leu Glu Pro Leu Val Gln Thr Met Asn Asp Leu Ser 
145                 150                 155                 160 


Gly His Gln Thr Ser Ile Phe Leu Cys Tyr Glu Glu Arg Arg Thr Gly 
                165                 170                 175     


Asn Lys Leu Glu Leu Glu Lys Lys Phe Phe Lys Leu Thr Lys Lys Leu 
            180                 185                 190         


Phe Thr Leu Glu Glu Ile Pro His Ser Lys Gln Asp Pro Leu Tyr His 
        195                 200                 205             


Ser Asn Asp Ile His Ile Leu His Leu Arg Arg His Pro Pro Ser Asp 
    210                 215                 220                 


Gly 
225 


<210>  6
<211>  235
<212>  PRT
<213>  Arabidopsis thaliana

<400>  6

Met Asp Pro Asp Arg Leu Asn Ser Pro Ser Thr Cys Thr Val Thr Ile 
1               5                   10                  15      


Glu Val Leu Gly His Glu Leu Asp Phe Ala Gln Asp Pro Asn Ser Lys 
            20                  25                  30          


His Leu Gly Thr Thr Val Trp Asp Ala Ser Met Val Phe Ala Lys Tyr 
        35                  40                  45              


Leu Gly Lys Asn Ser Arg Lys Gly Arg Phe Ser Ser Ser Lys Leu Lys 
    50                  55                  60                  


Gly Lys Arg Ala Ile Glu Leu Gly Ala Gly Cys Gly Val Ala Gly Phe 
65                  70                  75                  80  


Ala Leu Ala Met Leu Gly Cys Asp Val Val Thr Thr Asp Gln Lys Glu 
                85                  90                  95      


Val Leu Pro Leu Leu Lys Arg Asn Val Glu Trp Asn Thr Ser Arg Ile 
            100                 105                 110         


Val Gln Met Asn Pro Gly Ser Ala Phe Gly Ser Leu Arg Val Ala Glu 
        115                 120                 125             


Leu Asp Trp Gly Asn Glu Asp His Ile Thr Ala Val Glu Pro Pro Phe 
    130                 135                 140                 


Asp Tyr Val Ile Gly Thr Asp Val Val Tyr Ser Glu Gln Leu Leu Glu 
145                 150                 155                 160 


Pro Leu Leu Arg Thr Ile Leu Ala Leu Ser Gly Pro Lys Thr Thr Val 
                165                 170                 175     


Met Leu Gly Tyr Glu Ile Arg Ser Thr Val Val His Glu Lys Met Leu 
            180                 185                 190         


Gln Met Trp Lys Asp Asn Phe Glu Val Lys Thr Ile Pro Arg Ser Lys 
        195                 200                 205             


Met Asp Gly Glu Tyr Gln Asp Pro Ser Ile His Leu Tyr Ile Met Ala 
    210                 215                 220                 


Gln Lys Ser Ala Ala Glu Ser Ser Gly Asn Val 
225                 230                 235 


<210>  7
<211>  231
<212>  PRT
<213>  C. reinhardt

<400>  7

Met Val Glu Gln Glu Val Phe Gly Ser Val Leu Arg Phe Val Gln Asp 
1               5                   10                  15      


Pro Ser Ser Glu His Leu Gly Thr Thr Val Trp Asp Ala Ser Val Val 
            20                  25                  30          


Leu Ala Lys Trp Phe Glu Lys Asn Ile Arg Lys Gly Asp Phe Ala Arg 
        35                  40                  45              


Ser Lys Val Arg Gly Lys Arg Ala Leu Glu Leu Gly Ala Gly Met Gly 
    50                  55                  60                  


Leu Ala Gly Met Ala Phe Ala Met Val Gly Ala Asn Val Val Leu Thr 
65                  70                  75                  80  


Asp Thr Ala Asp Val Leu Pro Leu Leu Arg Ile Asn Tyr Glu Thr Asn 
                85                  90                  95      


Leu Ser Pro Ala Ala Val Arg Leu Ala Arg Gly His Gln His Gly Thr 
            100                 105                 110         


Trp Ala Asp Ser Ala Gly Thr Val Glu Val Gln Glu Leu Asp Trp Thr 
        115                 120                 125             


Lys Pro Glu Gln Val Ala Pro Leu His Pro Pro Tyr Asp Tyr Ile Leu 
    130                 135                 140                 


Ala Ala Asp Cys Ile Tyr His Glu Gly Leu Thr Glu Asp Phe His Arg 
145                 150                 155                 160 


Thr Val Met Gln Val Thr Asn Glu Lys Ser Thr Val Val Val Cys Asn 
                165                 170                 175     


Glu Leu Arg Ser His Ser Val Gln Gly Arg Phe Met Ser Leu Phe Thr 
            180                 185                 190         


Ala Thr His Ser Ile Lys Thr Val Pro His Ala Lys Met Asp Glu Lys 
        195                 200                 205             


Tyr Gln His Pro Asn Ile Phe Ile Tyr Ile Met Lys Lys Lys Lys Lys 
    210                 215                 220                 


Gly Thr Lys Ala Gly Ala Gly 
225                 230     


<210>  8
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  8

Lys Ala Phe Glu Glu Ala Glu Lys Asn Ala Pro Ala Ile Ile Phe Ile 
1               5                   10                  15      


Asp Glu Leu Asp Ala Ile Ala Pro Lys Arg Glu Lys Thr His Gly Glu 
            20                  25                  30          


Val Glu Arg 
        35  


<210>  9
<211>  38
<212>  DNA
<213>  Homo sapiens

<400>  9
gcgacggggc ccacgcgctg agccggcggt cggtgctg                               38


<210>  10
<211>  16
<212>  DNA
<213>  Homo sapiens

<400>  10
gcgacggggc ccacgc                                                       16


<210>  11
<211>  11
<212>  DNA
<213>  Homo sapiens

<400>  11
ggtcggtgct g                                                            11


<210>  12
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  12
cggcggtcgg tgctg                                                        15


<210>  13
<211>  11
<212>  DNA
<213>  Homo sapiens

<400>  13
gcgacggggc c                                                            11


<210>  14
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  14
tgagccggcg gtcggtgctg                                                   20


<210>  15
<211>  14
<212>  DNA
<213>  Homo sapiens

<400>  15
ggcggtcggt gctg                                                         14


<210>  16
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  16

Pro Ser Pro Pro Asp Phe Ile Leu Met Ala Asp Cys Ile Tyr Tyr Glu 
1               5                   10                  15      


Glu 
    


<210>  17
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  17

Pro Gly Glu Phe Asp Leu Ile Leu Gly Ala Asp Ile Ile Tyr Leu Glu 
1               5                   10                  15      


Glu 
    


<210>  18
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  18

Pro Ala Asn Tyr Asp Leu Val Leu Gly Ala Asp Ile Val Tyr Leu Glu 
1               5                   10                  15      


Pro 
    


<210>  19
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  19

Ala Phe Tyr Tyr Asp Tyr Val Leu Ala Ser Asp Val Val Tyr His His 
1               5                   10                  15      


Tyr 
    


<210>  20
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  20

Leu Pro Pro Gln Asp Ile Ile Leu Ala Ser Asp Val Phe Phe Glu Pro 
1               5                   10                  15      


Glu 
    


<210>  21
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  21

Ala Phe Gln Pro Asp Val Val Ile Ala Ala Asp Val Leu Tyr Cys Pro 
1               5                   10                  15      


Glu 
    


<210>  22
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  22

Tyr Asp His Thr Thr Ile Leu Phe Ala Ala Glu Val Phe Tyr Asp Asp 
1               5                   10                  15      


Asp 
    


<210>  23
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  23

Glu Gly His Phe Asp Ile Val Met Cys Ala Asp Cys Leu Phe Leu Asp 
1               5                   10                  15      


Gln 
    


<210>  24
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  24

Gln Asp Lys Trp Asp Leu Val Val Leu Gly Asp Met Phe Tyr Asp Glu 
1               5                   10                  15      


Asp 
    


<210>  25
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  25

Phe Val Lys Tyr Asp Leu Ile Leu Thr Ser Glu Thr Ile Tyr Asn Pro 
1               5                   10                  15      


Asp 
    


<210>  26
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  26

Gly Ala Pro Gln Lys Asp Ser Thr Gly Gly Val Leu Glu Glu Ser Asn 
1               5                   10                  15      


Lys 
    


<210>  27
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27
tgctacgact acagcagtat agctc                                             25


<210>  28
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28
tggtccctgg tgacttttat cttc                                              24


