                         SEQUENCE LISTING

<110>  The Regents of the University of Colorado
       Konkuk University
       Omni Bio Pharmaceutical, Inc.
       Dinarello, Charles A.
       Kim, SooHyun
       Crapo, James D.
 
<120>  COMPOSITIONS, METHODS AND USES FOR ALPHA-1 ANTITRYPSIN FUSION 
       MOLECULES

<130>  79487.000008

<150>  61/585,182
<151>  2012-01-10

<150>  61/586,038
<151>  2012-01-12

<150>  61/614,391
<151>  2012-03-22

<160>  58    

<170>  PatentIn version 3.5

<210>  1
<211>  394
<212>  PRT
<213>  Homo Sapiens

<400>  1

Glu Asp Pro Gln Gly Asp Ala Ala Gln Lys Thr Asp Thr Ser His His 
1               5                   10                  15      


Asp Gln Asp His Pro Thr Phe Asn Lys Ile Thr Pro Asn Leu Ala Glu 
            20                  25                  30          


Phe Ala Phe Ser Leu Tyr Arg Gln Leu Ala His Gln Ser Asn Ser Thr 
        35                  40                  45              


Asn Ile Phe Phe Ser Pro Val Ser Ile Ala Thr Ala Phe Ala Met Leu 
    50                  55                  60                  


Ser Leu Gly Thr Lys Ala Asp Thr His Asp Glu Ile Leu Glu Gly Leu 
65                  70                  75                  80  


Asn Phe Asn Leu Thr Glu Ile Pro Glu Ala Gln Ile His Glu Gly Phe 
                85                  90                  95      


Gln Glu Leu Leu Arg Thr Leu Asn Gln Pro Asp Ser Gln Leu Gln Leu 
            100                 105                 110         


Thr Thr Gly Asn Gly Leu Phe Leu Ser Glu Gly Leu Lys Leu Val Asp 
        115                 120                 125             


Lys Phe Leu Glu Asp Val Lys Lys Leu Tyr His Ser Glu Ala Phe Thr 
    130                 135                 140                 


Val Asn Phe Gly Asp Thr Glu Glu Ala Lys Lys Gln Ile Asn Asp Tyr 
145                 150                 155                 160 


Val Glu Lys Gly Thr Gln Gly Lys Ile Val Asp Leu Val Lys Glu Leu 
                165                 170                 175     


Asp Arg Asp Thr Val Phe Ala Leu Val Asn Tyr Ile Phe Phe Lys Gly 
            180                 185                 190         


Lys Trp Glu Arg Pro Phe Glu Val Lys Asp Thr Glu Glu Glu Asp Phe 
        195                 200                 205             


His Val Asp Gln Val Thr Thr Val Lys Val Pro Met Met Lys Arg Leu 
    210                 215                 220                 


Gly Met Phe Asn Ile Gln His Cys Lys Lys Leu Ser Ser Trp Val Leu 
225                 230                 235                 240 


Leu Met Lys Tyr Leu Gly Asn Ala Thr Ala Ile Phe Phe Leu Pro Asp 
                245                 250                 255     


Glu Gly Lys Leu Gln His Leu Glu Asn Glu Leu Thr His Asp Ile Ile 
            260                 265                 270         


Thr Lys Phe Leu Glu Asn Glu Asp Arg Arg Ser Ala Ser Leu His Leu 
        275                 280                 285             


Pro Lys Leu Ser Ile Thr Gly Thr Tyr Asp Leu Lys Ser Val Leu Gly 
    290                 295                 300                 


Gln Leu Gly Ile Thr Lys Val Phe Ser Asn Gly Ala Asp Leu Ser Gly 
305                 310                 315                 320 


Val Thr Glu Glu Ala Pro Leu Lys Leu Ser Lys Ala Val His Lys Ala 
                325                 330                 335     


Val Leu Thr Ile Asp Glu Lys Gly Thr Glu Ala Ala Gly Ala Met Phe 
            340                 345                 350         


Leu Glu Ala Ile Pro Met Ser Ile Pro Pro Glu Val Lys Phe Asn Lys 
        355                 360                 365             


Pro Phe Val Phe Leu Met Ile Glu Gln Asn Thr Lys Ser Pro Leu Phe 
    370                 375                 380                 


Met Gly Lys Val Val Asn Pro Thr Gln Lys 
385                 390                 


<210>  2
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  2

Phe Val Phe Leu Met 
1               5   


<210>  3
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  3

Phe Val Phe Ala Met 
1               5   


<210>  4
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  4

Phe Val Ala Leu Met 
1               5   


<210>  5
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  5

Phe Val Phe Leu Ala 
1               5   


<210>  6
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  6

Phe Leu Val Phe Ile 
1               5   


<210>  7
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  7

Phe Leu Met Ile Ile 
1               5   


<210>  8
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  8

Phe Leu Phe Val Leu 
1               5   


<210>  9
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  9

Phe Leu Phe Val Val 
1               5   


<210>  10
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  10

Phe Leu Phe Leu Ile 
1               5   


<210>  11
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  11

Phe Leu Phe Phe Ile 
1               5   


<210>  12
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  12

Phe Leu Met Phe Ile 
1               5   


<210>  13
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  13

Phe Met Leu Leu Ile 
1               5   


<210>  14
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  14

Phe Ile Ile Met Ile 
1               5   


<210>  15
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  15

Phe Leu Phe Cys Ile 
1               5   


<210>  16
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  16

Phe Leu Phe Ala Val 
1               5   


<210>  17
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  17

Phe Val Tyr Leu Ile 
1               5   


<210>  18
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  18

Phe Ala Phe Leu Met 
1               5   


<210>  19
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  19

Ala Val Phe Leu Met 
1               5   


<210>  20
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  20

Gly Ile Thr Lys Val Phe Ser Asn Gly Ala 
1               5                   10  


<210>  21
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  21

Asp Leu Ser Gly Val Thr Glu Glu Ala Pro 
1               5                   10  


<210>  22
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  22

Leu Lys Leu Ser Lys Ala Val His Lys Ala 
1               5                   10  


<210>  23
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  23

Val Leu Thr Ile Asp Glu Lys Gly Thr Glu 
1               5                   10  


<210>  24
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  24

Ala Ala Gly Ala Met Phe Leu Glu Ala Ile 
1               5                   10  


<210>  25
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  25

Pro Met Ser Ile Pro Pro Glu Val Lys Phe 
1               5                   10  


<210>  26
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  26

Asn Lys Pro Phe Val Phe Leu Met Ile Glu 
1               5                   10  


<210>  27
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  27

Gln Asn Thr Lys Ser Pro Leu Phe Met Gly 
1               5                   10  


<210>  28
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  28

Lys Val Val Asn Pro Thr Gln Lys 
1               5               


<210>  29
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  29

Leu Glu Ala Ile Pro Met Ser Ile Pro Pro Glu Val Lys Phe Asn Lys 
1               5                   10                  15      


Pro Phe Val Phe Leu Met 
            20          


<210>  30
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  30

Leu Glu Ala Ile Pro Met Ser Ile Pro Pro Glu Val Lys Phe Asn Lys 
1               5                   10                  15      


Pro Phe Val Phe 
            20  


<210>  31
<211>  80
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  31

Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys Leu Ser 
1               5                   10                  15      


Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly Thr Glu 
            20                  25                  30          


Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile Pro Pro 
        35                  40                  45              


Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu Gln Asn 
    50                  55                  60                  


Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr Gln Lys 
65                  70                  75                  80  


<210>  32
<211>  652
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FC-AAT fusion polypeptide

<400>  32

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala 
            20                  25                  30          


Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn 
        35                  40                  45              


Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln 
    50                  55                  60                  


Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser 
65                  70                  75                  80  


Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr 
                85                  90                  95      


His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro 
            100                 105                 110         


Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn 
        115                 120                 125             


Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu 
    130                 135                 140                 


Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys 
145                 150                 155                 160 


Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp Thr Glu Glu 
                165                 170                 175     


Ala Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys 
            180                 185                 190         


Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu 
        195                 200                 205             


Val Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val 
    210                 215                 220                 


Lys Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Ala Thr Thr Val 
225                 230                 235                 240 


Lys Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys 
                245                 250                 255     


Lys Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala 
            260                 265                 270         


Thr Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu 
        275                 280                 285             


Asn Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp 
    290                 295                 300                 


Arg Arg Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr 
305                 310                 315                 320 


Tyr Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe 
                325                 330                 335     


Ser Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys 
            340                 345                 350         


Leu Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly 
        355                 360                 365             


Thr Glu Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile 
    370                 375                 380                 


Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu 
385                 390                 395                 400 


Gln Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr 
                405                 410                 415     


Gln Lys Thr Arg Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
            420                 425                 430         


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        435                 440                 445             


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    450                 455                 460                 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
465                 470                 475                 480 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                485                 490                 495     


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            500                 505                 510         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        515                 520                 525             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    530                 535                 540                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
545                 550                 555                 560 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                565                 570                 575     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            580                 585                 590         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        595                 600                 605             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    610                 615                 620                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
625                 630                 635                 640 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                645                 650         


<210>  33
<211>  394
<212>  PRT
<213>  Homo Sapiens

<400>  33

Glu Asp Pro Gln Gly Asp Ala Ala Gln Lys Thr Asp Thr Ser His His 
1               5                   10                  15      


Asp Gln Asp His Pro Thr Phe Asn Lys Ile Thr Pro Asn Leu Ala Glu 
            20                  25                  30          


Phe Ala Phe Ser Leu Tyr Arg Gln Leu Ala His Gln Ser Asn Ser Thr 
        35                  40                  45              


Asn Ile Phe Phe Ser Pro Val Ser Ile Ala Thr Ala Phe Ala Met Leu 
    50                  55                  60                  


Ser Leu Gly Thr Lys Ala Asp Thr His Asp Glu Ile Leu Glu Gly Leu 
65                  70                  75                  80  


Asn Phe Asn Leu Thr Glu Ile Pro Glu Ala Gln Ile His Glu Gly Phe 
                85                  90                  95      


Gln Glu Leu Leu Arg Thr Leu Asn Gln Pro Asp Ser Gln Leu Gln Leu 
            100                 105                 110         


Thr Thr Gly Asn Gly Leu Phe Leu Ser Glu Gly Leu Lys Leu Val Asp 
        115                 120                 125             


Lys Phe Leu Glu Asp Val Lys Lys Leu Tyr His Ser Glu Ala Phe Thr 
    130                 135                 140                 


Val Asn Phe Gly Asp Thr Glu Glu Ala Lys Lys Gln Ile Asn Asp Tyr 
145                 150                 155                 160 


Val Glu Lys Gly Thr Gln Gly Lys Ile Val Asp Leu Val Lys Glu Leu 
                165                 170                 175     


Asp Arg Asp Thr Val Phe Ala Leu Val Asn Tyr Ile Phe Phe Lys Gly 
            180                 185                 190         


Lys Trp Glu Arg Pro Phe Glu Val Lys Asp Thr Glu Glu Glu Asp Phe 
        195                 200                 205             


His Val Asp Gln Ala Thr Thr Val Lys Val Pro Met Met Lys Arg Leu 
    210                 215                 220                 


Gly Met Phe Asn Ile Gln His Cys Lys Lys Leu Ser Ser Trp Val Leu 
225                 230                 235                 240 


Leu Met Lys Tyr Leu Gly Asn Ala Thr Ala Ile Phe Phe Leu Pro Asp 
                245                 250                 255     


Glu Gly Lys Leu Gln His Leu Glu Asn Glu Leu Thr His Asp Ile Ile 
            260                 265                 270         


Thr Lys Phe Leu Glu Asn Glu Asp Arg Arg Ser Ala Ser Leu His Leu 
        275                 280                 285             


Pro Lys Leu Ser Ile Thr Gly Thr Tyr Asp Leu Lys Ser Val Leu Gly 
    290                 295                 300                 


Gln Leu Gly Ile Thr Lys Val Phe Ser Asn Gly Ala Asp Leu Ser Gly 
305                 310                 315                 320 


Val Thr Glu Glu Ala Pro Leu Lys Leu Ser Lys Ala Val His Lys Ala 
                325                 330                 335     


Val Leu Thr Ile Asp Glu Lys Gly Thr Glu Ala Ala Gly Ala Met Phe 
            340                 345                 350         


Leu Glu Ala Ile Pro Met Ser Ile Pro Pro Glu Val Lys Phe Asn Lys 
        355                 360                 365             


Pro Phe Val Phe Leu Met Ile Glu Gln Asn Thr Lys Ser Pro Leu Phe 
    370                 375                 380                 


Met Gly Lys Val Val Asn Pro Thr Gln Lys 
385                 390                 


<210>  34
<211>  36
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  34

Ser Ile Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met 
1               5                   10                  15      


Ile Glu Gln Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn 
            20                  25                  30          


Pro Thr Gln Lys 
        35      


<210>  35
<211>  62
<212>  DNA
<213>  Homo sapiens

<400>  35
tttagaggcc atacccatgt ctatcccccc cgaggtcaag ttcaacaaac ccctttgtct       60

tt                                                                      62


<210>  36
<211>  62
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  36
tttagaggcc atatgcatgt ctatcccccc cgaggtcaag ttcaacaaac ccctttgtct       60

tt                                                                      62


<210>  37
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  37

Ala Ile Pro Arg Ser Ile Pro Pro Glu 
1               5                   


<210>  38
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  38

Ala Ile Pro Val Ser Ile Pro Pro Glu 
1               5                   


<210>  39
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  syntehtic peptide

<400>  39

Ala Ile Pro Val Ser Ile Pro Pro Glu 
1               5                   


<210>  40
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  40

Ala Ile Pro Leu Ser Ile Pro Pro Glu 
1               5                   


<210>  41
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  41

Ala Ile Cys Met Ser Ile Pro Pro Glu 
1               5                   


<210>  42
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  syntehtic peptide

<400>  42

Ala Ile Pro Ala Ser Ile Pro Pro Glu 
1               5                   


<210>  43
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  43

Ala Ile Pro Met Ser Ile Pro Pro Lys 
1               5                   


<210>  44
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  44

Ala Ala Gly Arg Ser Leu Asn Pro Glu 
1               5                   


<210>  45
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  45

Ile Ala Gly Arg Ser Leu Asn Pro Asn 
1               5                   


<210>  46
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  46

Ile Ala Gly Arg Leu Leu Asn Pro Asn 
1               5                   


<210>  47
<211>  1977
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  derived from human alpha-1 antitrypsin and human Fc fragment of 
       IgG1

<400>  47
gaattcgcca ccatgccgtc ttctgtctcg tggggcatcc tcctgctggc aggcctgtgc       60

tgcctggtcc ctgtctccct ggctgaggat ccccagggag atgctgccca gaagacagat      120

acatcccacc acgatcagga tcacccaacc ttcaacaaga tcacccccaa cctggctgag      180

ttcgccttca gcctataccg ccagctggca caccagtcca acagcaccaa tatcttcttc      240

tccccagtga gcatcgctac agcctttgca atgctctccc tggggaccaa ggctgacact      300

cacgatgaaa tcctggaggg cctgaatttc aacctcacgg agattccgga ggctcagatc      360

catgaaggct tccaggaact cctccgtacc ctcaaccagc cagacagcca gctccagctg      420

accaccggca atggcctgtt cctcagcgag ggcctgaagc tagtggataa gtttttggag      480

gatgttaaaa agttgtacca ctcagaagcc ttcactgtca acttcgggga caccgaagag      540

gccaagaaac agatcaacga ttacgtggag aagggtactc aagggaaaat tgtggatttg      600

gtcaaggagc ttgacagaga cacagttttt gctctggtga attacatctt ctttaaaggc      660

aaatgggaga gaccctttga agtcaaggac accgaggaag aggacttcca cgtggaccag      720

gcgaccaccg tgaaggtgcc tatgatgaag cgtttaggca tgtttaacat ccagcactgt      780

aagaagctgt ccagctgggt gctgctgatg aaatacctgg gcaatgccac cgccatcttc      840

ttcctgcctg atgaggggaa actacagcac ctggaaaatg aactcaccca cgatatcatc      900

accaagttcc tggaaaatga agacagaagg tctgccagct tacatttacc caaactgtcc      960

attactggaa cctatgatct gaagagcgtc ctgggtcaac tgggcatcac taaggtcttc     1020

agcaatgggg ctgacctctc cggggtcaca gaggaggcac ccctgaagct ctccaaggcc     1080

gtgcataagg ctgtgctgac catcgacgag aaagggactg aagctgctgg ggccatgttt     1140

ttagaggcca tacccatgtc tatccccccc gaggtcaagt tcaacaaacc ctttgtcttc     1200

ttaatgattg aacaaaatac caagtctccc ctcttcatgg gaaaagtggt gaatcccacc     1260

caaaaaacgc gtgagcccaa atcttgtgac aaaactcaca catgcccacc gtgcccagca     1320

cctgaactcc tggggggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc     1380

atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct     1440

gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg     1500

cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag     1560

gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccagccccc     1620

atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg     1680

cccccatccc gggatgagct gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc     1740

ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac     1800

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctacag caagctcacc     1860

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct     1920

ctgcacaacc actacacgca gaagagcctc tccctgtctc cgggtaaatg aggatct        1977


<210>  48
<211>  1950
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial: derived from human alpha-1 antitrypsin and human Fc 
       fragment of IgG1 with hinge deletion

<400>  48
gaattcgcca ccatgccgtc ttctgtctcg tggggcatcc tcctgctggc aggcctgtgc       60

tgcctggtcc ctgtctccct ggctgaggat ccccagggag atgctgccca gaagacagat      120

acatcccacc acgatcagga tcacccaacc ttcaacaaga tcacccccaa cctggctgag      180

ttcgccttca gcctataccg ccagctggca caccagtcca acagcaccaa tatcttcttc      240

tccccagtga gcatcgctac agcctttgca atgctctccc tggggaccaa ggctgacact      300

cacgatgaaa tcctggaggg cctgaatttc aacctcacgg agattccgga ggctcagatc      360

catgaaggct tccaggaact cctccgtacc ctcaaccagc cagacagcca gctccagctg      420

accaccggca atggcctgtt cctcagcgag ggcctgaagc tagtggataa gtttttggag      480

gatgttaaaa agttgtacca ctcagaagcc ttcactgtca acttcgggga caccgaagag      540

gccaagaaac agatcaacga ttacgtggag aagggtactc aagggaaaat tgtggatttg      600

gtcaaggagc ttgacagaga cacagttttt gctctggtga attacatctt ctttaaaggc      660

aaatgggaga gaccctttga agtcaaggac accgaggaag aggacttcca cgtggaccag      720

gcgaccaccg tgaaggtgcc tatgatgaag cgtttaggca tgtttaacat ccagcactgt      780

aagaagctgt ccagctgggt gctgctgatg aaatacctgg gcaatgccac cgccatcttc      840

ttcctgcctg atgaggggaa actacagcac ctggaaaatg aactcaccca cgatatcatc      900

accaagttcc tggaaaatga agacagaagg tctgccagct tacatttacc caaactgtcc      960

attactggaa cctatgatct gaagagcgtc ctgggtcaac tgggcatcac taaggtcttc     1020

agcaatgggg ctgacctctc cggggtcaca gaggaggcac ccctgaagct ctccaaggcc     1080

gtgcataagg ctgtgctgac catcgacgag aaagggactg aagctgctgg ggccatgttt     1140

ttagaggcca tacccatgtc tatccccccc gaggtcaagt tcaacaaacc ctttgtcttc     1200

ttaatgattg aacaaaatac caagtctccc ctcttcatgg gaaaagtggt gaatcccacc     1260

caaaaaacgc gtacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc     1320

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca     1380

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac     1440

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac     1500

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag     1560

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1620

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag     1680

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1740

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1800

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1860

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1920

ctctccctgt ctccgggtaa atgaggatct                                      1950


<210>  49
<211>  643
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  derived from human alpha-1 antitrypsin and human Fc fragment of 
       IgG1

<400>  49

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala 
            20                  25                  30          


Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn 
        35                  40                  45              


Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln 
    50                  55                  60                  


Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser 
65                  70                  75                  80  


Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr 
                85                  90                  95      


His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro 
            100                 105                 110         


Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn 
        115                 120                 125             


Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu 
    130                 135                 140                 


Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys 
145                 150                 155                 160 


Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp Thr Glu Glu 
                165                 170                 175     


Ala Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys 
            180                 185                 190         


Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu 
        195                 200                 205             


Val Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val 
    210                 215                 220                 


Lys Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Ala Thr Thr Val 
225                 230                 235                 240 


Lys Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys 
                245                 250                 255     


Lys Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala 
            260                 265                 270         


Thr Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu 
        275                 280                 285             


Asn Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp 
    290                 295                 300                 


Arg Arg Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr 
305                 310                 315                 320 


Tyr Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe 
                325                 330                 335     


Ser Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys 
            340                 345                 350         


Leu Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly 
        355                 360                 365             


Thr Glu Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile 
    370                 375                 380                 


Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu 
385                 390                 395                 400 


Gln Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr 
                405                 410                 415     


Gln Lys Thr Arg Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
            420                 425                 430         


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        435                 440                 445             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    450                 455                 460                 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
465                 470                 475                 480 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
                485                 490                 495     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            500                 505                 510         


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        515                 520                 525             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    530                 535                 540                 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
545                 550                 555                 560 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                565                 570                 575     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            580                 585                 590         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        595                 600                 605             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    610                 615                 620                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
625                 630                 635                 640 


Pro Gly Lys 
            


<210>  50
<211>  1962
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  derived from human alpha-1 antitrypsin and human Fc fragment of 
       IgG2

<400>  50
gaattcgcca ccatgccgtc ttctgtctcg tggggcatcc tcctgctggc aggcctgtgc       60

tgcctggtcc ctgtctccct ggctgaggat ccccagggag atgctgccca gaagacagat      120

acatcccacc acgatcagga tcacccaacc ttcaacaaga tcacccccaa cctggctgag      180

ttcgccttca gcctataccg ccagctggca caccagtcca acagcaccaa tatcttcttc      240

tccccagtga gcatcgctac agcctttgca atgctctccc tggggaccaa ggctgacact      300

cacgatgaaa tcctggaggg cctgaatttc aacctcacgg agattccgga ggctcagatc      360

catgaaggct tccaggaact cctccgtacc ctcaaccagc cagacagcca gctccagctg      420

accaccggca atggcctgtt cctcagcgag ggcctgaagc tagtggataa gtttttggag      480

gatgttaaaa agttgtacca ctcagaagcc ttcactgtca acttcgggga caccgaagag      540

gccaagaaac agatcaacga ttacgtggag aagggtactc aagggaaaat tgtggatttg      600

gtcaaggagc ttgacagaga cacagttttt gctctggtga attacatctt ctttaaaggc      660

aaatgggaga gaccctttga agtcaaggac accgaggaag aggacttcca cgtggaccag      720

gcgaccaccg tgaaggtgcc tatgatgaag cgtttaggca tgtttaacat ccagcactgt      780

aagaagctgt ccagctgggt gctgctgatg aaatacctgg gcaatgccac cgccatcttc      840

ttcctgcctg atgaggggaa actacagcac ctggaaaatg aactcaccca cgatatcatc      900

accaagttcc tggaaaatga agacagaagg tctgccagct tacatttacc caaactgtcc      960

attactggaa cctatgatct gaagagcgtc ctgggtcaac tgggcatcac taaggtcttc     1020

agcaatgggg ctgacctctc cggggtcaca gaggaggcac ccctgaagct ctccaaggcc     1080

gtgcataagg ctgtgctgac catcgacgag aaagggactg aagctgctgg ggccatgttt     1140

ttagaggcca tacccatgtc tatccccccc gaggtcaagt tcaacaaacc ctttgtcttc     1200

ttaatgattg aacaaaatac caagtctccc ctcttcatgg gaaaagtggt gaatcccacc     1260

caaaaaacgc gtcgcaaatg ttgtgtcgag tgcccaccgt gcccagcacc acctgtggca     1320

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc     1380

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac     1440

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac     1500

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc     1560

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1620

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat     1680

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1740

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1800

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1860

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1920

acgcagaaga gcctctccct gtctccgggt aaatgaggat ct                        1962


<210>  51
<211>  647
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  derived from human alpha-1 antitrypsin and human Fc fragment of 
       IgG2

<400>  51

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala 
            20                  25                  30          


Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn 
        35                  40                  45              


Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln 
    50                  55                  60                  


Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser 
65                  70                  75                  80  


Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr 
                85                  90                  95      


His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro 
            100                 105                 110         


Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn 
        115                 120                 125             


Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu 
    130                 135                 140                 


Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys 
145                 150                 155                 160 


Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp Thr Glu Glu 
                165                 170                 175     


Ala Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys 
            180                 185                 190         


Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu 
        195                 200                 205             


Val Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val 
    210                 215                 220                 


Lys Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Ala Thr Thr Val 
225                 230                 235                 240 


Lys Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys 
                245                 250                 255     


Lys Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala 
            260                 265                 270         


Thr Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu 
        275                 280                 285             


Asn Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp 
    290                 295                 300                 


Arg Arg Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr 
305                 310                 315                 320 


Tyr Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe 
                325                 330                 335     


Ser Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys 
            340                 345                 350         


Leu Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly 
        355                 360                 365             


Thr Glu Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile 
    370                 375                 380                 


Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu 
385                 390                 395                 400 


Gln Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr 
                405                 410                 415     


Gln Lys Thr Arg Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala 
            420                 425                 430         


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        435                 440                 445             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    450                 455                 460                 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
465                 470                 475                 480 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                485                 490                 495     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            500                 505                 510         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
        515                 520                 525             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    530                 535                 540                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
545                 550                 555                 560 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                565                 570                 575     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            580                 585                 590         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        595                 600                 605             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    610                 615                 620                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
625                 630                 635                 640 


Leu Ser Leu Ser Pro Gly Lys 
                645         


<210>  52
<211>  1995
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  derived from human alpha-1 antitrypsin and human Fc fragment of 
       IgG3

<400>  52
gaattcgcca ccatgccgtc ttctgtctcg tggggcatcc tcctgctggc aggcctgtgc       60

tgcctggtcc ctgtctccct ggctgaggat ccccagggag atgctgccca gaagacagat      120

acatcccacc acgatcagga tcacccaacc ttcaacaaga tcacccccaa cctggctgag      180

ttcgccttca gcctataccg ccagctggca caccagtcca acagcaccaa tatcttcttc      240

tccccagtga gcatcgctac agcctttgca atgctctccc tggggaccaa ggctgacact      300

cacgatgaaa tcctggaggg cctgaatttc aacctcacgg agattccgga ggctcagatc      360

catgaaggct tccaggaact cctccgtacc ctcaaccagc cagacagcca gctccagctg      420

accaccggca atggcctgtt cctcagcgag ggcctgaagc tagtggataa gtttttggag      480

gatgttaaaa agttgtacca ctcagaagcc ttcactgtca acttcgggga caccgaagag      540

gccaagaaac agatcaacga ttacgtggag aagggtactc aagggaaaat tgtggatttg      600

gtcaaggagc ttgacagaga cacagttttt gctctggtga attacatctt ctttaaaggc      660

aaatgggaga gaccctttga agtcaaggac accgaggaag aggacttcca cgtggaccag      720

gcgaccaccg tgaaggtgcc tatgatgaag cgtttaggca tgtttaacat ccagcactgt      780

aagaagctgt ccagctgggt gctgctgatg aaatacctgg gcaatgccac cgccatcttc      840

ttcctgcctg atgaggggaa actacagcac ctggaaaatg aactcaccca cgatatcatc      900

accaagttcc tggaaaatga agacagaagg tctgccagct tacatttacc caaactgtcc      960

attactggaa cctatgatct gaagagcgtc ctgggtcaac tgggcatcac taaggtcttc     1020

agcaatgggg ctgacctctc cggggtcaca gaggaggcac ccctgaagct ctccaaggcc     1080

gtgcataagg ctgtgctgac catcgacgag aaagggactg aagctgctgg ggccatgttt     1140

ttagaggcca tacccatgtc tatccccccc gaggtcaagt tcaacaaacc ctttgtcttc     1200

ttaatgattg aacaaaatac caagtctccc ctcttcatgg gaaaagtggt gaatcccacc     1260

caaaaaacgc gtccatgccc acggtgccca gagcccaaat cttgtgacac acctcccccg     1320

tgcccaaggt gcccagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca     1380

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac     1440

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     1500

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     1560

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac     1620

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     1680

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg     1740

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     1800

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1860

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     1920

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     1980

ggtaaatgag gatct                                                      1995


<210>  53
<211>  658
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  derived from human alpha-1 antitrypsin and human Fc fragment of 
       IgG3

<400>  53

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala 
            20                  25                  30          


Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn 
        35                  40                  45              


Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln 
    50                  55                  60                  


Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser 
65                  70                  75                  80  


Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr 
                85                  90                  95      


His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro 
            100                 105                 110         


Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn 
        115                 120                 125             


Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu 
    130                 135                 140                 


Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys 
145                 150                 155                 160 


Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp Thr Glu Glu 
                165                 170                 175     


Ala Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys 
            180                 185                 190         


Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu 
        195                 200                 205             


Val Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val 
    210                 215                 220                 


Lys Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Ala Thr Thr Val 
225                 230                 235                 240 


Lys Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys 
                245                 250                 255     


Lys Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala 
            260                 265                 270         


Thr Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu 
        275                 280                 285             


Asn Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp 
    290                 295                 300                 


Arg Arg Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr 
305                 310                 315                 320 


Tyr Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe 
                325                 330                 335     


Ser Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys 
            340                 345                 350         


Leu Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly 
        355                 360                 365             


Thr Glu Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile 
    370                 375                 380                 


Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu 
385                 390                 395                 400 


Gln Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr 
                405                 410                 415     


Gln Lys Thr Arg Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
            420                 425                 430         


Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala Pro Glu Leu Leu Gly Gly 
        435                 440                 445             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    450                 455                 460                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
465                 470                 475                 480 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                485                 490                 495     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            500                 505                 510         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        515                 520                 525             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    530                 535                 540                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
545                 550                 555                 560 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                565                 570                 575     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            580                 585                 590         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        595                 600                 605             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    610                 615                 620                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
625                 630                 635                 640 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                645                 650                 655     


Gly Lys 
        


<210>  54
<211>  1965
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  derived from human alpha-1 antitrypsin and human Fc fragment of 
       IgG4

<400>  54
gaattcgcca ccatgccgtc ttctgtctcg tggggcatcc tcctgctggc aggcctgtgc       60

tgcctggtcc ctgtctccct ggctgaggat ccccagggag atgctgccca gaagacagat      120

acatcccacc acgatcagga tcacccaacc ttcaacaaga tcacccccaa cctggctgag      180

ttcgccttca gcctataccg ccagctggca caccagtcca acagcaccaa tatcttcttc      240

tccccagtga gcatcgctac agcctttgca atgctctccc tggggaccaa ggctgacact      300

cacgatgaaa tcctggaggg cctgaatttc aacctcacgg agattccgga ggctcagatc      360

catgaaggct tccaggaact cctccgtacc ctcaaccagc cagacagcca gctccagctg      420

accaccggca atggcctgtt cctcagcgag ggcctgaagc tagtggataa gtttttggag      480

gatgttaaaa agttgtacca ctcagaagcc ttcactgtca acttcgggga caccgaagag      540

gccaagaaac agatcaacga ttacgtggag aagggtactc aagggaaaat tgtggatttg      600

gtcaaggagc ttgacagaga cacagttttt gctctggtga attacatctt ctttaaaggc      660

aaatgggaga gaccctttga agtcaaggac accgaggaag aggacttcca cgtggaccag      720

gcgaccaccg tgaaggtgcc tatgatgaag cgtttaggca tgtttaacat ccagcactgt      780

aagaagctgt ccagctgggt gctgctgatg aaatacctgg gcaatgccac cgccatcttc      840

ttcctgcctg atgaggggaa actacagcac ctggaaaatg aactcaccca cgatatcatc      900

accaagttcc tggaaaatga agacagaagg tctgccagct tacatttacc caaactgtcc      960

attactggaa cctatgatct gaagagcgtc ctgggtcaac tgggcatcac taaggtcttc     1020

agcaatgggg ctgacctctc cggggtcaca gaggaggcac ccctgaagct ctccaaggcc     1080

gtgcataagg ctgtgctgac catcgacgag aaagggactg aagctgctgg ggccatgttt     1140

ttagaggcca tacccatgtc tatccccccc gaggtcaagt tcaacaaacc ctttgtcttc     1200

ttaatgattg aacaaaatac caagtctccc ctcttcatgg gaaaagtggt gaatcccacc     1260

caaaaaacgc gttccaaata tggtccccca tgcccatcat gcccagcacc tgagttcctg     1320

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg     1380

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc     1440

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag     1500

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     1560

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     1620

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1680

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1740

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1800

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1860

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1920

tacacgcaga agagcctctc cctgtctccg ggtaaatgag gatct                     1965


<210>  55
<211>  648
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  derived from human alpha-1 antitrypsin and human Fc fragment of 
       IgG4

<400>  55

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala 
            20                  25                  30          


Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn 
        35                  40                  45              


Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln 
    50                  55                  60                  


Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser 
65                  70                  75                  80  


Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr 
                85                  90                  95      


His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro 
            100                 105                 110         


Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn 
        115                 120                 125             


Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu 
    130                 135                 140                 


Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys 
145                 150                 155                 160 


Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp Thr Glu Glu 
                165                 170                 175     


Ala Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys 
            180                 185                 190         


Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu 
        195                 200                 205             


Val Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val 
    210                 215                 220                 


Lys Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Ala Thr Thr Val 
225                 230                 235                 240 


Lys Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys 
                245                 250                 255     


Lys Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala 
            260                 265                 270         


Thr Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu 
        275                 280                 285             


Asn Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp 
    290                 295                 300                 


Arg Arg Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr 
305                 310                 315                 320 


Tyr Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe 
                325                 330                 335     


Ser Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys 
            340                 345                 350         


Leu Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly 
        355                 360                 365             


Thr Glu Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile 
    370                 375                 380                 


Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu 
385                 390                 395                 400 


Gln Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr 
                405                 410                 415     


Gln Lys Thr Arg Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala 
            420                 425                 430         


Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        435                 440                 445             


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    450                 455                 460                 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
465                 470                 475                 480 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                485                 490                 495     


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
            500                 505                 510         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
        515                 520                 525             


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    530                 535                 540                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
545                 550                 555                 560 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                565                 570                 575     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            580                 585                 590         


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        595                 600                 605             


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
    610                 615                 620                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
625                 630                 635                 640 


Ser Leu Ser Leu Ser Pro Gly Lys 
                645             


<210>  56
<211>  634
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  derived from human alpha-1 antitrypsin and human Fc fragment of 
       IgG2 with hinge deletion

<400>  56

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala 
            20                  25                  30          


Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn 
        35                  40                  45              


Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln 
    50                  55                  60                  


Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser 
65                  70                  75                  80  


Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr 
                85                  90                  95      


His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro 
            100                 105                 110         


Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn 
        115                 120                 125             


Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu 
    130                 135                 140                 


Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys 
145                 150                 155                 160 


Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp Thr Glu Glu 
                165                 170                 175     


Ala Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys 
            180                 185                 190         


Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu 
        195                 200                 205             


Val Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val 
    210                 215                 220                 


Lys Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Ala Thr Thr Val 
225                 230                 235                 240 


Lys Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys 
                245                 250                 255     


Lys Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala 
            260                 265                 270         


Thr Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu 
        275                 280                 285             


Asn Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp 
    290                 295                 300                 


Arg Arg Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr 
305                 310                 315                 320 


Tyr Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe 
                325                 330                 335     


Ser Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys 
            340                 345                 350         


Leu Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly 
        355                 360                 365             


Thr Glu Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile 
    370                 375                 380                 


Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu 
385                 390                 395                 400 


Gln Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr 
                405                 410                 415     


Gln Lys Thr Arg Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
            420                 425                 430         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        435                 440                 445             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    450                 455                 460                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
465                 470                 475                 480 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                485                 490                 495     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            500                 505                 510         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        515                 520                 525             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
    530                 535                 540                 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
545                 550                 555                 560 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                565                 570                 575     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            580                 585                 590         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        595                 600                 605             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    610                 615                 620                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
625                 630                 


<210>  57
<211>  632
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  derived from human alpha-1 antitrypsin and human Fc fragment of 
       IgG3 with hinge deletion)

<400>  57

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala 
            20                  25                  30          


Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn 
        35                  40                  45              


Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln 
    50                  55                  60                  


Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser 
65                  70                  75                  80  


Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr 
                85                  90                  95      


His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro 
            100                 105                 110         


Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn 
        115                 120                 125             


Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu 
    130                 135                 140                 


Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys 
145                 150                 155                 160 


Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp Thr Glu Glu 
                165                 170                 175     


Ala Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys 
            180                 185                 190         


Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu 
        195                 200                 205             


Val Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val 
    210                 215                 220                 


Lys Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Ala Thr Thr Val 
225                 230                 235                 240 


Lys Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys 
                245                 250                 255     


Lys Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala 
            260                 265                 270         


Thr Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu 
        275                 280                 285             


Asn Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp 
    290                 295                 300                 


Arg Arg Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr 
305                 310                 315                 320 


Tyr Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe 
                325                 330                 335     


Ser Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys 
            340                 345                 350         


Leu Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly 
        355                 360                 365             


Thr Glu Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile 
    370                 375                 380                 


Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu 
385                 390                 395                 400 


Gln Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr 
                405                 410                 415     


Gln Lys Thr Arg Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            420                 425                 430         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        435                 440                 445             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    450                 455                 460                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
465                 470                 475                 480 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                485                 490                 495     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            500                 505                 510         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        515                 520                 525             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    530                 535                 540                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
545                 550                 555                 560 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                565                 570                 575     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            580                 585                 590         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        595                 600                 605             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    610                 615                 620                 


Ser Leu Ser Leu Ser Pro Gly Lys 
625                 630         


<210>  58
<211>  632
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  derived from human alpha-1 antitrypsin and human Fc fragment of 
       IgG4 with hinge deletion

<400>  58

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala 
            20                  25                  30          


Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn 
        35                  40                  45              


Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln 
    50                  55                  60                  


Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser 
65                  70                  75                  80  


Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr 
                85                  90                  95      


His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro 
            100                 105                 110         


Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn 
        115                 120                 125             


Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu 
    130                 135                 140                 


Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys 
145                 150                 155                 160 


Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp Thr Glu Glu 
                165                 170                 175     


Ala Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys 
            180                 185                 190         


Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu 
        195                 200                 205             


Val Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val 
    210                 215                 220                 


Lys Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Ala Thr Thr Val 
225                 230                 235                 240 


Lys Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys 
                245                 250                 255     


Lys Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala 
            260                 265                 270         


Thr Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu 
        275                 280                 285             


Asn Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp 
    290                 295                 300                 


Arg Arg Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr 
305                 310                 315                 320 


Tyr Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe 
                325                 330                 335     


Ser Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys 
            340                 345                 350         


Leu Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly 
        355                 360                 365             


Thr Glu Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile 
    370                 375                 380                 


Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu 
385                 390                 395                 400 


Gln Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr 
                405                 410                 415     


Gln Lys Thr Arg Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            420                 425                 430         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        435                 440                 445             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    450                 455                 460                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
465                 470                 475                 480 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                485                 490                 495     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            500                 505                 510         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        515                 520                 525             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    530                 535                 540                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
545                 550                 555                 560 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                565                 570                 575     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            580                 585                 590         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        595                 600                 605             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    610                 615                 620                 


Ser Leu Ser Leu Ser Pro Gly Lys 
625                 630         


