                         SEQUENCE LISTING

<110>  ALETHIA BIOTHERAPEUTICS INC.
       TREMBLAY, Gilles   Bernard
       MORAITIS, Anna  N.
       FILION, Mario
 
<120>  METHOD OF TREATING BREAST CANCER

<130>  11504-134

<140>  PCT/CA2013/000011
<141>  2013-01-09

<150>  US61/584,629
<151>  2012-01-09

<160>  216   

<170>  PatentIn version 3.5

<210>  1
<211>  885
<212>  DNA
<213>  Homo sapiens

<300>
<308>  UniProtKB/Q9UBP8
<309>  1999-12-20
<313>  (1)..(885)

<400>  1
gaggggcatc aatcacaccg agaagtcaca gcccctcaac cactgaggtg tgggggggta       60

gggatctgca tttcttcata tcaaccccac actatagggc acctaaatgg gtgggcggtg      120

ggggagaccg actcacttga gtttcttgaa ggcttcctgg cctccagcca cgtaattgcc      180

cccgctctgg atctggtcta gcttccggat tcggtggcca gtccgcgggg tgtagatgtt      240

cctgacggcc ccaaagggtg cctgaacgcc gccggtcacc tccttcagga agacttcgaa      300

gctggacacc ttcttctcat ggatgacgac gcggcgcccc gcgtagaagg ggtccccgtt      360

gcggtacaca agcacgctct tcacgacggg ctgagacagg tggctggacc tggcgctgct      420

gccgctcatc ttccccgctg gccgccgcct cagctcgctg cttcgcgtcg ggaggcacct      480

ccgctgtccc agcggcctca ccgcacccag ggcgcgggat cgcctcctga aacgaacgag      540

aaactgacga atccacaggt gaaagagaag taacggccgt gcgcctaggc gtccacccag      600

aggagacact aggagcttgc aggactcgga gtagacgctc aagtttttca ccgtggcgtg      660

cacagccaat caggacccgc agtgcgcgca ccacaccagg ttcacctgct acgggcagaa      720

tcaaggtgga cagcttctga gcaggagccg gaaacgcgcg gggccttcaa acaggcacgc      780

ctagtgaggg caggagagag gaggacgcac acacacacac acacacaaat atggtgaaac      840

ccaatttctt acatcatatc tgtgctaccc tttccaaaca gccta                      885


<210>  2
<211>  84
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProtKB/Q9UBP8
<309>  1999-12-20
<313>  (1)..(84)

<400>  2

Met Asp Asp Asp Ala Ala Pro Arg Val Glu Gly Val Pro Val Ala Val 
1               5                   10                  15      


His Lys His Ala Leu His Asp Gly Leu Arg Gln Val Ala Gly Pro Gly 
            20                  25                  30          


Ala Ala Ala Ala His Leu Pro Arg Trp Pro Pro Pro Gln Leu Ala Ala 
        35                  40                  45              


Ser Arg Arg Glu Ala Pro Pro Leu Ser Gln Arg Pro His Arg Thr Gln 
    50                  55                  60                  


Gly Ala Gly Ser Pro Pro Glu Thr Asn Glu Lys Leu Thr Asn Pro Gln 
65                  70                  75                  80  


Val Lys Glu Lys 
                


<210>  3
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3D3 light chain

<400>  3
gacattgtga tgacccagtc tccatcctcc ctggctgtgt caataggaca gaaggtcact       60

atgaactgca agtccagtca gagcctttta aatagtaact ttcaaaagaa ctttttggcc      120

tggtaccagc agaaaccagg ccagtctcct aaacttctga tatactttgc atccactcgg      180

gaatctagta tccctgatcg cttcataggc agtggatctg ggacagattt cactcttacc      240

atcagcagtg tgcaggctga agacctggca gattacttct gtcagcaaca ttatagcact      300

ccgctcacgt tcggtgctgg gaccaagctg gagctgaaag ctgtggctgc accatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt         657


<210>  4
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3D3 light chain

<400>  4

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ile Gly 
1               5                   10                  15      


Gln Lys Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Asn Phe Gln Lys Asn Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Phe Ala Ser Thr Arg Glu Ser Ser Ile 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
                85                  90                  95      


His Tyr Ser Thr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys Ala Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  5
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3D3 heavy chain

<400>  5
gaggttcagc tgcagcagtc tgtagctgag ctggtgaggc ctggggcttc agtgacgctg       60

tcctgcaagg cttcgggcta catatttact gactatgaga tacactgggt gaagcagact      120

cctgtgcatg gcctggaatg gattggggtt attgatcctg aaactggtaa tactgccttc      180

aatcagaagt tcaagggcaa ggccacactg actgcagaca tatcctccag cacagcctac      240

atggaactca gcagtttgac atctgaggac tctgccgtct attactgtat gggttattct      300

gattattggg gccaaggcac cactctcaca gtctcctcag cctcaacgaa gggcccatct      360

gtctttcccc tggccccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc      420

ctggtcaagg actacttccc cgaaccggtg acggtgtcgt ggaactcagg cgccctgacc      480

agcggcgtgc acaccttccc ggctgtccta cagtcctcag gactctactc cctcagcagc      540

gtggtgaccg tgccctccag cagcttgggc acccagacct acatctgcaa cgtgaatcac      600

aagcccagca acaccaaggt ggacaagaaa gttgagccca aatcttgtga attcactcac      660

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc      720

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      780

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg      840

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc      900

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc      960

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1020

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc     1080

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     1140

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1200

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1260

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     1320

cccgggaaa                                                             1329


<210>  6
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3D3 heavy chain

<400>  6

Glu Val Gln Leu Gln Gln Ser Val Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asp Tyr 
            20                  25                  30          


Glu Ile His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asp Pro Glu Thr Gly Asn Thr Ala Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Ile Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Met Gly Tyr Ser Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
        115                 120                 125             


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
            180                 185                 190         


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Lys Val Glu Pro Lys Ser Cys Glu Phe Thr His Thr Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
            340                 345                 350         


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             


<210>  7
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3G10 light chain

<400>  7
gatgttttga tgacccaaac tccacgctcc ctgtctgtca gtcttggaga tcaagcctcc       60

atctcttgta gatcgagtca gagcctttta catagtaatg gaaacaccta tttagaatgg      120

tatttgcaga aaccaggcca gcctccaaag gtcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcggagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttcct      300

ctcacgttcg gtgctgggac caagctggag ctgaaagctg tggctgcacc atctgtcttc      360

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg      420

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg      480

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc      540

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc      600

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgt            654


<210>  8
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G10 light chain

<400>  8

Asp Val Leu Met Thr Gln Thr Pro Arg Ser Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Pro 
        35                  40                  45              


Pro Lys Val Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Gly Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


Ala Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  9
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3G10 heavy chain

<400>  9
gagatccagc tgcagcagtc tggacctgag ttggtgaagc ctggggcttc agtgaagata       60

tcctgtaagg cttctggata caccttcact gacaactaca tgaactgggt gaagcagagc      120

catggaaaga gccttgagtg gattggagat attaatcctt actatggtac tactacctac      180

aaccagaagt tcaagggcaa ggccacattg actgtagaca agtcctcccg cacagcctac      240

atggagctcc gcggcctgac atctgaggac tctgcagtct attactgtgc aagagatgac      300

tggtttgatt attggggcca agggactctg gtcactgtct ctgcagcctc aacgaagggc      360

ccatctgtct ttcccctggc cccctcctcc aagagcacct ctgggggcac agcggccctg      420

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc      480

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc      540

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg      600

aatcacaagc ccagcaacac caaggtggac aagaaagttg agcccaaatc ttgtgaattc      660

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc      720

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      780

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg      840

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg      900

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag      960

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag     1020

ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag     1080

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1140

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1200

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1260

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1320

ctgtctcccg ggaaa                                                      1335


<210>  10
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G10 heavy chain

<400>  10

Glu Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Asn 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Tyr Tyr Gly Thr Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Asp Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Glu Phe Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 


<210>  11
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3C4 light chain

<400>  11
gacatcgtta tgtctcagtc tccatcttcc atgtatgcat ctctaggaga gagagtcact       60

atcacttgca aggcgagtca ggacattcat aactttttaa actggttcca gcagaaacca      120

ggaaaatctc caaagaccct gatctttcgt gcaaacagat tggtagatgg ggtcccatca      180

aggttcagtg gcagtggatc tgggcaagat tattctctca ccatcagcag cctggagttt      240

gaagatttgg gaatttattc ttgtctacag tatgatgaga ttccgctcac gttcggtgct      300

gggaccaagc tggagctgag agctgtggct gcaccatctg tcttcatctt cccgccatct      360

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc      420

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag      480

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg      540

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg      600

agctcgcccg tcacaaagag cttcaacagg ggagagtgt                             639


<210>  12
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3C4 light chain

<400>  12

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile His Asn Phe 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Phe Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Phe 
65                  70                  75                  80  


Glu Asp Leu Gly Ile Tyr Ser Cys Leu Gln Tyr Asp Glu Ile Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Arg Ala Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  13
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3C4 heavy chain

<400>  13
gaggtgcagc ttcaggagtc aggacctgac ctggtgaaac cttctcagtc actttcactc       60

acctgcactg tcactggctt ctccatcacc agtggttatg gctggcactg gatccggcag      120

tttccaggaa acaaactgga gtggatgggc tacataaact acgatggtca caatgactac      180

aacccatctc tcaaaagtcg aatctctatc actcaagaca catccaagaa ccagttcttc      240

ctgcagttga attctgtgac tactgaggac acagccacat attactgtgc aagcagttac      300

gacggcttat ttgcttactg gggccaaggg actctggtca ctgtctctgc agcctcaacg      360

aagggcccat ctgtctttcc cctggccccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      660

gaattcactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      780

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      900

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      960

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag     1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1200

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320

ctctccctgt ctcccgggaa a                                               1341


<210>  14
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3C4 heavy chain

<400>  14

Glu Val Gln Leu Gln Glu Ser Gly Pro Asp Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Phe Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Gly Trp His Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Asn Tyr Asp Gly His Asn Asp Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Gln Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Tyr Asp Gly Leu Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Glu Phe Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  15
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3D3 light chain variable region

<400>  15
gacattgtga tgacccagtc tccatcctcc ctggctgtgt caataggaca gaaggtcact       60

atgaactgca agtccagtca gagcctttta aatagtaact ttcaaaagaa ctttttggcc      120

tggtaccagc agaaaccagg ccagtctcct aaacttctga tatactttgc atccactcgg      180

gaatctagta tccctgatcg cttcataggc agtggatctg ggacagattt cactcttacc      240

atcagcagtg tgcaggctga agacctggca gattacttct gtcagcaaca ttatagcact      300

ccgctcacgt tcggtgctgg gaccaagctg gagctgaaa                             339


<210>  16
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3D3 light chain variable region

<400>  16

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ile Gly 
1               5                   10                  15      


Gln Lys Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Asn Phe Gln Lys Asn Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Phe Ala Ser Thr Arg Glu Ser Ser Ile 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
                85                  90                  95      


His Tyr Ser Thr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  17
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3D3 heavy chain variable region

<400>  17
gaggttcagc tgcagcagtc tgtagctgag ctggtgaggc ctggggcttc agtgacgctg       60

tcctgcaagg cttcgggcta catatttact gactatgaga tacactgggt gaagcagact      120

cctgtgcatg gcctggaatg gattggggtt attgatcctg aaactggtaa tactgccttc      180

aatcagaagt tcaagggcaa ggccacactg actgcagaca tatcctccag cacagcctac      240

atggaactca gcagtttgac atctgaggac tctgccgtct attactgtat gggttattct      300

gattattggg gccaaggcac cactctcaca gtctcctca                             339


<210>  18
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3D3 heavy chain variable region

<400>  18

Glu Val Gln Leu Gln Gln Ser Val Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asp Tyr 
            20                  25                  30          


Glu Ile His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asp Pro Glu Thr Gly Asn Thr Ala Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Ile Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Met Gly Tyr Ser Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  19
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3G10 light chain variable region

<400>  19
gatgttttga tgacccaaac tccacgctcc ctgtctgtca gtcttggaga tcaagcctcc       60

atctcttgta gatcgagtca gagcctttta catagtaatg gaaacaccta tttagaatgg      120

tatttgcaga aaccaggcca gcctccaaag gtcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcggagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttcct      300

ctcacgttcg gtgctgggac caagctggag ctgaaa                                336


<210>  20
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G10 light chain variable region

<400>  20

Asp Val Leu Met Thr Gln Thr Pro Arg Ser Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Pro 
        35                  40                  45              


Pro Lys Val Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Gly Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  21
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3G10 heavy chain variable region

<400>  21
gagatccagc tgcagcagtc tggacctgag ttggtgaagc ctggggcttc agtgaagata       60

tcctgtaagg cttctggata caccttcact gacaactaca tgaactgggt gaagcagagc      120

catggaaaga gccttgagtg gattggagat attaatcctt actatggtac tactacctac      180

aaccagaagt tcaagggcaa ggccacattg actgtagaca agtcctcccg cacagcctac      240

atggagctcc gcggcctgac atctgaggac tctgcagtct attactgtgc aagagatgac      300

tggtttgatt attggggcca agggactctg gtcactgtct ctgca                      345


<210>  22
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G10 heavy chain variable region

<400>  22

Glu Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Asn 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Tyr Tyr Gly Thr Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Asp Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  23
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3C4 light chain variable region

<400>  23
gacatcgtta tgtctcagtc tccatcttcc atgtatgcat ctctaggaga gagagtcact       60

atcacttgca aggcgagtca ggacattcat aactttttaa actggttcca gcagaaacca      120

ggaaaatctc caaagaccct gatctttcgt gcaaacagat tggtagatgg ggtcccatca      180

aggttcagtg gcagtggatc tgggcaagat tattctctca ccatcagcag cctggagttt      240

gaagatttgg gaatttattc ttgtctacag tatgatgaga ttccgctcac gttcggtgct      300

gggaccaagc tggagctgag a                                                321


<210>  24
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3C4 light chain variable region

<400>  24

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile His Asn Phe 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Phe Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Phe 
65                  70                  75                  80  


Glu Asp Leu Gly Ile Tyr Ser Cys Leu Gln Tyr Asp Glu Ile Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Arg 
            100                 105         


<210>  25
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3C4 heavy chain variable region

<400>  25
gaggtgcagc ttcaggagtc aggacctgac ctggtgaaac cttctcagtc actttcactc       60

acctgcactg tcactggctt ctccatcacc agtggttatg gctggcactg gatccggcag      120

tttccaggaa acaaactgga gtggatgggc tacataaact acgatggtca caatgactac      180

aacccatctc tcaaaagtcg aatctctatc actcaagaca catccaagaa ccagttcttc      240

ctgcagttga attctgtgac tactgaggac acagccacat attactgtgc aagcagttac      300

gacggcttat ttgcttactg gggccaaggg actctggtca ctgtctctgc a               351


<210>  26
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3C4 heavy chain variable region

<400>  26

Glu Val Gln Leu Gln Glu Ser Gly Pro Asp Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Phe Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Gly Trp His Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Asn Tyr Asp Gly His Asn Asp Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Gln Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Tyr Asp Gly Leu Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  27
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3D3 light chain CDR1

<400>  27

Lys Ser Ser Gln Ser Leu Leu Asn Ser Asn Phe Gln Lys Asn Phe Leu 
1               5                   10                  15      


Ala 
    


<210>  28
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3D3 light chain CDR2

<400>  28

Phe Ala Ser Thr Arg Glu Ser 
1               5           


<210>  29
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3D3 light chain CDR3

<400>  29

Gln Gln His Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  30
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3D3 heavy chain CDR1

<400>  30

Gly Tyr Ile Phe Thr Asp Tyr Glu Ile His 
1               5                   10  


<210>  31
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3D3 heavy chain CDR2

<400>  31

Val Ile Asp Pro Glu Thr Gly Asn Thr Ala 
1               5                   10  


<210>  32
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3D3 heavy chain CDR3

<400>  32

Met Gly Tyr Ser Asp Tyr 
1               5       


<210>  33
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G10 light chain CDR1

<400>  33

Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  34
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G10 light chain CDR2

<400>  34

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  35
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G10 light chain CDR3

<400>  35

Phe Gln Gly Ser His Val Pro Leu Thr 
1               5                   


<210>  36
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G10 heavy chain CDR1

<400>  36

Gly Tyr Thr Phe Thr Asp Asn Tyr Met Asn 
1               5                   10  


<210>  37
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G10 heavy chain CDR2

<400>  37

Asp Ile Asn Pro Tyr Tyr Gly Thr Thr Thr 
1               5                   10  


<210>  38
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G10 heavy chain CDR3

<400>  38

Ala Arg Asp Asp Trp Phe Asp Tyr 
1               5               


<210>  39
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3C4 light chain CDR1

<400>  39

Lys Ala Ser Gln Asp Ile His Asn Phe Leu Asn 
1               5                   10      


<210>  40
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3C4 light chain CDR2

<400>  40

Arg Ala Asn Arg Leu Val Asp 
1               5           


<210>  41
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3C4 light chain CDR3

<400>  41

Leu Gln Tyr Asp Glu Ile Pro Leu Thr 
1               5                   


<210>  42
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3C4 heavy chain CDR1

<400>  42

Gly Phe Ser Ile Thr Ser Gly Tyr Gly Trp His 
1               5                   10      


<210>  43
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3C4 heavy chain CDR2

<400>  43

Tyr Ile Asn Tyr Asp Gly His Asn Asp 
1               5                   


<210>  44
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3C4 heavy chain CDR3

<400>  44

Ala Ser Ser Tyr Asp Gly Leu Phe Ala Tyr 
1               5                   10  


<210>  45
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3A4 heavy chain variable region

<400>  45
cagatccagt tggtgcaatc tggacctgag atggtgaagc ctggggcttc agtgaagatg       60

tcctgtaagg cttctggata cacattcact gacgactaca tgagctgggt gaaacagagc      120

catggaaaga gccttgagtg gattggagat attaatcctt acaacggtga tactaactac      180

aaccagaagt tcaagggcaa ggccatattg actgtagaca aatcctccag cacagcctac      240

atgcagctca acagcctgac atcggaagac tcagcagtct attactgtgc aagagacccg      300

ggggctatgg actactgggg tcaaggaacc tcagtcaccg tctcctca                   348


<210>  46
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A4 heavy chain variable region

<400>  46

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Met Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Asp 
            20                  25                  30          


Tyr Met Ser Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Tyr Asn Gly Asp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Ile Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  47
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3A4 light chain variable region

<400>  47
gatgttgtga tgacccaaac tccactctcc ctggctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagccttcta catagtaatg gaaacaccta tttagaatgg      120

taccttcaga aaccaggcca gtctccaaag ctcctgatcc acacagtttc caaccgattt      180

tctggggtcc cagacagatt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttccg      300

ctcacgttcg gtgctgggac caggctggag ctgaaa                                336


<210>  48
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A4 light chain variable region

<400>  48

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile His Thr Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Arg Leu Glu Leu Lys 
            100                 105                 110         


<210>  49
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A4 heavy chain CDR1

<400>  49

Gly Tyr Thr Phe Thr Asp Asp Tyr Met Ser 
1               5                   10  


<210>  50
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A4 heavy chain CDR2

<400>  50

Asp Ile Asn Pro Tyr Asn Gly Asp Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  51
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A4 heavy chain CDR3

<400>  51

Asp Pro Gly Ala Met Asp Tyr 
1               5           


<210>  52
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A4 light chain CDR1

<400>  52

Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  53
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A4 light chain CDR2

<400>  53

Thr Val Ser Asn Arg Phe Ser 
1               5           


<210>  54
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A4 light chain CDR3

<400>  54

Phe Gln Gly Ser His Val Pro Leu Thr 
1               5                   


<210>  55
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer OSG 1773

<400>  55
gtaagcagcg ctgtggctgc accatctgtc ttc                                    33


<210>  56
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer OSG 1774

<400>  56
gtaagcgcta gcctaacact ctcccctgtt gaagc                                  35


<210>  57
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human kappa constant region

<400>  57
gctgtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga       60

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg      120

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc      180

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa      240

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc      300

ttcaacaggg gagagtgtta g                                                321


<210>  58
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human kappa constant region

<400>  58

Ala Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  59
<211>  6385
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid pTTVK1

<400>  59
cttgagccgg cggatggtcg aggtgaggtg tggcaggctt gagatccagc tgttggggtg       60

agtactccct ctcaaaagcg ggcattactt ctgcgctaag attgtcagtt tccaaaaacg      120

aggaggattt gatattcacc tggcccgatc tggccataca cttgagtgac aatgacatcc      180

actttgcctt tctctccaca ggtgtccact cccaggtcca agtttaaacg gatctctagc      240

gaattcatga actttctgct gtcttgggtg cattggagcc ttgccttgct gctctacctc      300

caccatgcca agtggtccca ggcttgagac ggagcttaca gcgctgtggc tgcaccatct      360

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc      420

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc      480

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc      540

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc      600

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt      660

tagggtaccg cggccgcttc gaatgagatc ccccgacctc gacctctggc taataaagga      720

aatttatttt cattgcaata gtgtgttgga attttttgtg tctctcactc ggaaggacat      780

atgggagggc aaatcatttg gtcgagatcc ctcggagatc tctagctaga gccccgccgc      840

cggacgaact aaacctgact acggcatctc tgccccttct tcgcggggca gtgcatgtaa      900

tcccttcagt tggttggtac aacttgccaa ctgggccctg ttccacatgt gacacggggg      960

gggaccaaac acaaaggggt tctctgactg tagttgacat ccttataaat ggatgtgcac     1020

atttgccaac actgagtggc tttcatcctg gagcagactt tgcagtctgt ggactgcaac     1080

acaacattgc ctttatgtgt aactcttggc tgaagctctt acaccaatgc tgggggacat     1140

gtacctccca ggggcccagg aagactacgg gaggctacac caacgtcaat cagaggggcc     1200

tgtgtagcta ccgataagcg gaccctcaag agggcattag caatagtgtt tataaggccc     1260

ccttgttaac cctaaacggg tagcatatgc ttcccgggta gtagtatata ctatccagac     1320

taaccctaat tcaatagcat atgttaccca acgggaagca tatgctatcg aattagggtt     1380

agtaaaaggg tcctaaggaa cagcgatatc tcccacccca tgagctgtca cggttttatt     1440

tacatggggt caggattcca cgagggtagt gaaccatttt agtcacaagg gcagtggctg     1500

aagatcaagg agcgggcagt gaactctcct gaatcttcgc ctgcttcttc attctccttc     1560

gtttagctaa tagaataact gctgagttgt gaacagtaag gtgtatgtga ggtgctcgaa     1620

aacaaggttt caggtgacgc ccccagaata aaatttggac ggggggttca gtggtggcat     1680

tgtgctatga caccaatata accctcacaa accccttggg caataaatac tagtgtagga     1740

atgaaacatt ctgaatatct ttaacaatag aaatccatgg ggtggggaca agccgtaaag     1800

actggatgtc catctcacac gaatttatgg ctatgggcaa cacataatcc tagtgcaata     1860

tgatactggg gttattaaga tgtgtcccag gcagggacca agacaggtga accatgttgt     1920

tacactctat ttgtaacaag gggaaagaga gtggacgccg acagcagcgg actccactgg     1980

ttgtctctaa cacccccgaa aattaaacgg ggctccacgc caatggggcc cataaacaaa     2040

gacaagtggc cactcttttt tttgaaattg tggagtgggg gcacgcgtca gcccccacac     2100

gccgccctgc ggttttggac tgtaaaataa gggtgtaata acttggctga ttgtaacccc     2160

gctaaccact gcggtcaaac cacttgccca caaaaccact aatggcaccc cggggaatac     2220

ctgcataagt aggtgggcgg gccaagatag gggcgcgatt gctgcgatct ggaggacaaa     2280

ttacacacac ttgcgcctga gcgccaagca cagggttgtt ggtcctcata ttcacgaggt     2340

cgctgagagc acggtgggct aatgttgcca tgggtagcat atactaccca aatatctgga     2400

tagcatatgc tatcctaatc tatatctggg tagcataggc tatcctaatc tatatctggg     2460

tagcatatgc tatcctaatc tatatctggg tagtatatgc tatcctaatt tatatctggg     2520

tagcataggc tatcctaatc tatatctggg tagcatatgc tatcctaatc tatatctggg     2580

tagtatatgc tatcctaatc tgtatccggg tagcatatgc tatcctaata gagattaggg     2640

tagtatatgc tatcctaatt tatatctggg tagcatatac tacccaaata tctggatagc     2700

atatgctatc ctaatctata tctgggtagc atatgctatc ctaatctata tctgggtagc     2760

ataggctatc ctaatctata tctgggtagc atatgctatc ctaatctata tctgggtagt     2820

atatgctatc ctaatttata tctgggtagc ataggctatc ctaatctata tctgggtagc     2880

atatgctatc ctaatctata tctgggtagt atatgctatc ctaatctgta tccgggtagc     2940

atatgctatc ctcacgatga taagctgtca aacatgagaa ttaattcttg aagacgaaag     3000

ggcctcgtga tacgcctatt tttataggtt aatgtcatga taataatggt ttcttagacg     3060

tcaggtggca cttttcgggg aaatgtgcgc ggaaccccta tttgtttatt tttctaaata     3120

cattcaaata tgtatccgct catgagacaa taaccctgat aaatgcttca ataatattga     3180

aaaaggaaga gtatgagtat tcaacatttc cgtgtcgccc ttattccctt ttttgcggca     3240

ttttgccttc ctgtttttgc tcacccagaa acgctggtga aagtaaaaga tgctgaagat     3300

cagttgggtg cacgagtggg ttacatcgaa ctggatctca acagcggtaa gatccttgag     3360

agttttcgcc ccgaagaacg ttttccaatg atgagcactt ttaaagttct gctatgtggc     3420

gcggtattat cccgtgttga cgccgggcaa gagcaactcg gtcgccgcat acactattct     3480

cagaatgact tggttgagta ctcaccagtc acagaaaagc atcttacgga tggcatgaca     3540

gtaagagaat tatgcagtgc tgccataacc atgagtgata acactgcggc caacttactt     3600

ctgacaacga tcggaggacc gaaggagcta accgcttttt tgcacaacat gggggatcat     3660

gtaactcgcc ttgatcgttg ggaaccggag ctgaatgaag ccataccaaa cgacgagcgt     3720

gacaccacga tgcctgcagc aatggcaaca acgttgcgca aactattaac tggcgaacta     3780

cttactctag cttcccggca acaattaata gactggatgg aggcggataa agttgcagga     3840

ccacttctgc gctcggccct tccggctggc tggtttattg ctgataaatc tggagccggt     3900

gagcgtgggt ctcgcggtat cattgcagca ctggggccag atggtaagcc ctcccgtatc     3960

gtagttatct acacgacggg gagtcaggca actatggatg aacgaaatag acagatcgct     4020

gagataggtg cctcactgat taagcattgg taactgtcag accaagttta ctcatatata     4080

ctttagattg atttaaaact tcatttttaa tttaaaagga tctaggtgaa gatccttttt     4140

gataatctca tgaccaaaat cccttaacgt gagttttcgt tccactgagc gtcagacccc     4200

gtagaaaaga tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg     4260

caaacaaaaa aaccaccgct accagcggtg gtttgtttgc cggatcaaga gctaccaact     4320

ctttttccga aggtaactgg cttcagcaga gcgcagatac caaatactgt ccttctagtg     4380

tagccgtagt taggccacca cttcaagaac tctgtagcac cgcctacata cctcgctctg     4440

ctaatcctgt taccagtggc tgctgccagt ggcgataagt cgtgtcttac cgggttggac     4500

tcaagacgat agttaccgga taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca     4560

cagcccagct tggagcgaac gacctacacc gaactgagat acctacagcg tgagcattga     4620

gaaagcgcca cgcttcccga agggagaaag gcggacaggt atccggtaag cggcagggtc     4680

ggaacaggag agcgcacgag ggagcttcca gggggaaacg cctggtatct ttatagtcct     4740

gtcgggtttc gccacctctg acttgagcgt cgatttttgt gatgctcgtc aggggggcgg     4800

agcctatgga aaaacgccag caacgcggcc tttttacggt tcctggcctt ttgctggcct     4860

tttgctcaca tgttctttcc tgcgttatcc cctgattctg tggataaccg tattaccgcc     4920

tttgagtgag ctgataccgc tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc     4980

gaggaagcgg aagagcgccc aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat     5040

taatgcagct ggcacgacag gtttcccgac tggaaagcgg gcagtgagcg caacgcaatt     5100

aatgtgagtt agctcactca ttaggcaccc caggctttac actttatgct tccggctcgt     5160

atgttgtgtg gaattgtgag cggataacaa tttcacacag gaaacagcta tgaccatgat     5220

tacgccaagc tctagctaga ggtcgaccaa ttctcatgtt tgacagctta tcatcgcaga     5280

tccgggcaac gttgttgcat tgctgcaggc gcagaactgg taggtatggc agatctatac     5340

attgaatcaa tattggcaat tagccatatt agtcattggt tatatagcat aaatcaatat     5400

tggctattgg ccattgcata cgttgtatct atatcataat atgtacattt atattggctc     5460

atgtccaata tgaccgccat gttgacattg attattgact agttattaat agtaatcaat     5520

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa     5580

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt     5640

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta     5700

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtccgcccc ctattgacgt     5760

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttac gggactttcc     5820

tacttggcag tacatctacg tattagtcat cgctattacc atggtgatgc ggttttggca     5880

gtacaccaat gggcgtggat agcggtttga ctcacgggga tttccaagtc tccaccccat     5940

tgacgtcaat gggagtttgt tttggcacca aaatcaacgg gactttccaa aatgtcgtaa     6000

taaccccgcc ccgttgacgc aaatgggcgg taggcgtgta cggtgggagg tctatataag     6060

cagagctcgt ttagtgaacc gtcagatcct cactctcttc cgcatcgctg tctgcgaggg     6120

ccagctgttg ggctcgcggt tgaggacaaa ctcttcgcgg tctttccagt actcttggat     6180

cggaaacccg tcggcctccg aacggtactc cgccaccgag ggacctgagc gagtccgcat     6240

cgaccggatc ggaaaacctc tcgagaaagg cgtctaacca gtcacagtcg caaggtaggc     6300

tgagcaccgt ggcgggcggc agcgggtggc ggtcggggtt gtttctggcg gaggtgctgc     6360

tgatgatgta attaaagtag gcggt                                           6385


<210>  60
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  60
atgccaagtg gtcccaggct gacattgtga tgacccagtc tcc                         43


<210>  61
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  61
atgccaagtg gtcccaggct gatgttttga tgacccaaac tcc                         43


<210>  62
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  62
atgccaagtg gtcccaggct gacatcgtta tgtctcagtc tcc                         43


<210>  63
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  63
gggaagatga agacagatgg tgcagccaca gc                                     32


<210>  64
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  64
gtaagcgcta gcgcctcaac gaagggccca tctgtctttc ccctggcccc                  50


<210>  65
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  65
gtaagcgaat tcacaagatt tgggctcaac tttcttg                                37


<210>  66
<211>  309
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG1 CH1 region

<400>  66
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcag ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgt                                                              309


<210>  67
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 CH1 region

<400>  67

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys 
            100             


<210>  68
<211>  5379
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid pYD15

<400>  68
cttgagccgg cggatggtcg aggtgaggtg tggcaggctt gagatccagc tgttggggtg       60

agtactccct ctcaaaagcg ggcattactt ctgcgctaag attgtcagtt tccaaaaacg      120

aggaggattt gatattcacc tggcccgatc tggccataca cttgagtgac aatgacatcc      180

actttgcctt tctctccaca ggtgtccact cccaggtcca agtttgccgc caccatggag      240

acagacacac tcctgctatg ggtactgctg ctctgggttc caggttccac tggcggagac      300

ggagcttacg ggcccatctg tctttcccct ggccccctcc tccaagagca cctctggggg      360

cacagcggcc ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg      420

gaactcaggc gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg      480

actctactcc ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta      540

catctgcaac gtgaatcaca agcccagcaa caccaaggtg gacaagaaag ttgagcccaa      600

atcttgtgaa ttcactcaca catgcccacc gtgcccagca cctgaactcc tggggggacc      660

gtcagtcttc ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga      720

ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta      780

cgtggacggc gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag      840

cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga      900

gtacaagtgc aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa      960

agccaaaggg cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct     1020

gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc     1080

cgtggagtgg gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct     1140

ggactccgac ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca     1200

gcaggggaac gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca     1260

gaagagcctc tccctgtctc ccgggaaatg atcccccgac ctcgacctct ggctaataaa     1320

ggaaatttat tttcattgca atagtgtgtt ggaatttttt gtgtctctca ctcggaagga     1380

catatgggag ggcaaatcat ttggtcgaga tccctcggag atctctagct agagccccgc     1440

cgccggacga actaaacctg actacggcat ctctgcccct tcttcgcggg gcagtgcatg     1500

taatcccttc agttggttgg tacaacttgc caactgaacc ctaaacgggt agcatatgct     1560

tcccgggtag tagtatatac tatccagact aaccctaatt caatagcata tgttacccaa     1620

cgggaagcat atgctatcga attagggtta gtaaaagggt cctaaggaac agcgatgtag     1680

gtgggcgggc caagataggg gcgcgattgc tgcgatctgg aggacaaatt acacacactt     1740

gcgcctgagc gccaagcaca gggttgttgg tcctcatatt cacgaggtcg ctgagagcac     1800

ggtgggctaa tgttgccatg ggtagcatat actacccaaa tatctggata gcatatgcta     1860

tcctaatcta tatctgggta gcataggcta tcctaatcta tatctgggta gcatatgcta     1920

tcctaatcta tatctgggta gtatatgcta tcctaattta tatctgggta gcataggcta     1980

tcctaatcta tatctgggta gcatatgcta tcctaatcta tatctgggta gtatatgcta     2040

tcctaatctg tatccgggta gcatatgcta tcctaataga gattagggta gtatatgcta     2100

tcctaattta tatctgggta gcatatacta cccaaatatc tggatagcat atgctatcct     2160

aatctatatc tgggtagcat atgctatcct aatctatatc tgggtagcat aggctatcct     2220

aatctatatc tgggtagcat atgctatcct aatctatatc tgggtagtat atgctatcct     2280

aatttatatc tgggtagcat aggctatcct aatctatatc tgggtagcat atgctatcct     2340

aatctatatc tgggtagtat atgctatcct aatctgtatc cgggtagcat atgctatcct     2400

cacgatgata agctgtcaaa catgagaatt aattcttgaa gacgaaaggg cctcgtgata     2460

cgcctatttt tataggttaa tgtcatgata ataatggttt cttagacgtc aggtggcact     2520

tttcggggaa atgtgcgcgg aacccctatt tgtttatttt tctaaataca ttcaaatatg     2580

tatccgctca tgagacaata accctgataa atgcttcaat aatattgaaa aaggaagagt     2640

atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt ttgccttcct     2700

gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca     2760

cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag ttttcgcccc     2820

gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc ggtattatcc     2880

cgtgttgacg ccgggcaaga gcaactcggt cgccgcatac actattctca gaatgacttg     2940

gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt aagagaatta     3000

tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct gacaacgatc     3060

ggaggaccga aggagctaac cgcttttttg cacaacatgg gggatcatgt aactcgcctt     3120

gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga caccacgatg     3180

cctgcagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact tactctagct     3240

tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc acttctgcgc     3300

tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga gcgtgggtct     3360

cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt agttatctac     3420

acgacgggga gtcaggcaac tatggatgaa cgaaatagac agatcgctga gataggtgcc     3480

tcactgatta agcattggta actgtcagac caagtttact catatatact ttagattgat     3540

ttaaaacttc atttttaatt taaaaggatc taggtgaaga tcctttttga taatctcatg     3600

accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt agaaaagatc     3660

aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa     3720

ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct ttttccgaag     3780

gtaactggct tcagcagagc gcagatacca aatactgtcc ttctagtgta gccgtagtta     3840

ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct aatcctgtta     3900

ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc aagacgatag     3960

ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca gcccagcttg     4020

gagcgaacga cctacaccga actgagatac ctacagcgtg agcattgaga aagcgccacg     4080

cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg aacaggagag     4140

cgcacgaggg agcttccagg gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc     4200

cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggcggag cctatggaaa     4260

aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt tgctcacatg     4320

ttctttcctg cgttatcccc tgattctgtg gataaccgta ttaccgcctt tgagtgagct     4380

gataccgctc gccgcagccg aacgaccgag cgcagcgagt cagtgagcga ggaagcgtac     4440

atttatattg gctcatgtcc aatatgaccg ccatgttgac attgattatt gactagttat     4500

taatagtaat caattacggg gtcattagtt catagcccat atatggagtt ccgcgttaca     4560

taacttacgg taaatggccc gcctggctga ccgcccaacg acccccgccc attgacgtca     4620

ataatgacgt atgttcccat agtaacgcca atagggactt tccattgacg tcaatgggtg     4680

gagtatttac ggtaaactgc ccacttggca gtacatcaag tgtatcatat gccaagtccg     4740

ccccctattg acgtcaatga cggtaaatgg cccgcctggc attatgccca gtacatgacc     4800

ttacgggact ttcctacttg gcagtacatc tacgtattag tcatcgctat taccatggtg     4860

atgcggtttt ggcagtacac caatgggcgt ggatagcggt ttgactcacg gggatttcca     4920

agtctccacc ccattgacgt caatgggagt ttgttttggc accaaaatca acgggacttt     4980

ccaaaatgtc gtaataaccc cgccccgttg acgcaaatgg gcggtaggcg tgtacggtgg     5040

gaggtctata taagcagagc tcgtttagtg aaccgtcaga tcctcactct cttccgcatc     5100

gctgtctgcg agggccagct gttgggctcg cggttgagga caaactcttc gcggtctttc     5160

cagtactctt ggatcggaaa cccgtcggcc tccgaacggt actccgccac cgagggacct     5220

gagcgagtcc gcatcgaccg gatcggaaaa cctctcgaga aaggcgtcta accagtcaca     5280

gtcgcaaggt aggctgagca ccgtggcggg cggcagcggg tggcggtcgg ggttgtttct     5340

ggcggaggtg ctgctgatga tgtaattaaa gtaggcggt                            5379


<210>  69
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  69
gggttccagg ttccactggc gaggttcagc tgcagcagtc tgt                         43


<210>  70
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  70
gggttccagg ttccactggc gaggtgcagc ttcaggagtc agg                         43


<210>  71
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  71
ggggccaggg gaaagacaga tgggcccttc gttgaggc                               38


<210>  72
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain CDR1 consensus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa may be a basic amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa may be a basic amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa may be H, Y or N

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa may be S, T, N or R

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa may be absent, S or N

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa may be D, F or N

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa may be G or Q

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa may be K, L or N

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa may be T or N

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa may be an aromatic amino acid

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa may be A, N, E or Y

<400>  72

Xaa Ser Ser Xaa Ser Leu Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu 
1               5                   10                  15      


Xaa 
    


<210>  73
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain CDR1 consensus


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa may be an hydrophobic amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa may be G or H

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa may be T, N or R

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa may be F, Y or A

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa may be an hydrophobic amino acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa may be N or A

<400>  73

Lys Ala Ser Gln Asp Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10      


<210>  74
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain CDR2 consensus


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa may be A or G

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa may be R or T

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa may be E, K or A

<400>  74

Phe Xaa Ser Thr Xaa Xaa Ser 
1               5           


<210>  75
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain CDR2 consensus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa may be L or K

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa may be a basic amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa may be L or R

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa may be D or F

<400>  75

Xaa Val Ser Xaa Xaa Xaa Ser 
1               5           


<210>  76
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain CDR2 consensus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa may be a basic amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa may be D or A

<400>  76

Xaa Ala Asn Arg Leu Val Xaa 
1               5           


<210>  77
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain CDR3 consensus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa may be Q or L

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa may be an aromatic amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa may be D, F or Y

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa may be E, A, N or S

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa may be I, F or T

<400>  77

Xaa Gln Xaa Xaa Xaa Xaa Pro Leu Thr 
1               5                   


<210>  78
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain CDR3 consensus


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa may be an aromatic amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa may be N or S

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa may be I or T

<400>  78

Gln Gln His Xaa Xaa Xaa Pro Leu Thr 
1               5                   


<210>  79
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain CDR3 consensus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa may be an aromatic amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa may be a neutral hydrophilic amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa may be F or V

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa may be R or L

<400>  79

Xaa Gln Gly Xaa His Xaa Pro Xaa Thr 
1               5                   


<210>  80
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain CDR1 consensus


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa may be T, I or K

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa may be a neutral hydrophilic amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa may be an acidic amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa may be E, N or D

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa may be an hydrophobic amino acid

<400>  80

Gly Tyr Xaa Phe Xaa Xaa Tyr Xaa Xaa His 
1               5                   10  


<210>  81
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain CDR2 consensus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa may be V or G

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa may be an hydrophobic amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa may be A, G or E

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa may be R, G, D, A, S, N or V

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa may be an hydrophobic amino acid

<400>  81

Xaa Xaa Asp Pro Xaa Thr Gly Xaa Thr Xaa 
1               5                   10  


<210>  82
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain CDR2 consensus


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa may be an hydrophobic amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa may be A, E or G

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa may be R, G, A, S, N, V or D

<400>  82

Val Xaa Asp Pro Xaa Thr Gly Xaa Thr Ala 
1               5                   10  


<210>  83
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain CDR2 consensus


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa may be S or N

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa may be an aromatic amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa may be D, E or N

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa may be D or H

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa may be Y, S or N

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa may be D, E or N

<400>  83

Tyr Ile Xaa Xaa Xaa Gly Xaa Xaa Xaa 
1               5                   


<210>  84
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain CDR2 consensus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa may be N or Y

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa may be E, D or N

<400>  84

Xaa Ile Asn Pro Tyr Asn Xaa Val Thr Glu 
1               5                   10  


<210>  85
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain CDR2 consensus


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa may be N or Y

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa may be G or T

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa may be I or T

<400>  85

Asp Ile Asn Pro Xaa Tyr Gly Xaa Xaa Thr 
1               5                   10  


<210>  86
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain CDR3 consensus


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa may be G or S

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa may be Y or H

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa may be A or S

<400>  86

Met Xaa Xaa Xaa Asp Tyr 
1               5       


<210>  87
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain CDR3 consensus


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa may be G or S

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa may be absent or M

<400>  87

Ile Xaa Tyr Ala Xaa Asp Tyr 
1               5           


<210>  88
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain CDR3 consensus


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa may be R or W

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa may be an aromatic amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa may be a basic amino acid

<400>  88

Ala Xaa Xaa Gly Leu Arg Xaa 
1               5           


<210>  89
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 consensus


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa may be N or H

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa may be S or T

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa may be S, N or D

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa may be N or G

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa may be Q, N or K

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa may be K or L

<400>  89

Lys Ser Ser Gln Ser Leu Leu Xaa Xaa Xaa Xaa Xaa Xaa Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  90
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 consensus


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa may be N or T

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa may be Y or F

<400>  90

Lys Ala Ser Gln Asp Ile His Xaa Xaa Leu Asn 
1               5                   10      


<210>  91
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 consensus

<400>  91

Phe Ala Ser Thr Arg Glu Ser 
1               5           


<210>  92
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 consensus

<400>  92

Leu Val Ser Lys Leu Asp Ser 
1               5           


<210>  93
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 consensus

<400>  93

Arg Ala Asn Arg Leu Val Asp 
1               5           


<210>  94
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 consensus

<400>  94

Gln Gln His Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  95
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 consensus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa may be W or L

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa may be Y or G

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa may be D or T

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa may be A, E or H

<400>  95

Xaa Gln Xaa Xaa Xaa Phe Pro Arg Thr 
1               5                   


<210>  96
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 consensus


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa may be T or I

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa may be D or E

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa may be E or N

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa may be M, I or V

<400>  96

Gly Tyr Xaa Phe Thr Xaa Tyr Xaa Xaa His 
1               5                   10  


<210>  97
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 consensus


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa may be T or S

<400>  97

Gly Phe Xaa Ile Thr Ser Gly Tyr Gly Trp His 
1               5                   10      


<210>  98
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 consensus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa may be V, N or G

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa may be I or L

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa may be E, A or G

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa may be T or Y

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<400>  98

Xaa Xaa Asp Pro Xaa Xaa Gly Xaa Thr Ala 
1               5                   10  


<210>  99
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 consensus


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa may be N or S

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa may be F or Y

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa may be N or D

<400>  99

Tyr Ile Xaa Xaa Xaa Gly 
1               5       


<210>  100
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 consensus


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa may be S or A

<400>  100

Met Gly Tyr Xaa Asp Tyr 
1               5       


<210>  101
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 consensus

<400>  101

Ala Ser Ser Tyr Asp Gly Phe Leu Ala Tyr 
1               5                   10  


<210>  102
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 consensus


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa may be R or W

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa may be W or F

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa may be Q or N

<400>  102

Ala Xaa Xaa Gly Leu Arg Xaa 
1               5           


<210>  103
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A2 light chain variable region

<400>  103

Asp Ala Val Met Thr Gln Ile Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Leu Ser Cys Lys Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Ser Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Leu Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Arg Thr Phe Ala Gly Gly Thr Asn Leu Glu Ile Lys 
            100                 105                 110         


<210>  104
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F6 light chain variable region

<400>  104

Ser Ile Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Ser Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Gly Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  105
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E8 light chain variable region

<400>  105

Asp Ala Val Met Thr Gln Ile Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  106
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E10 light chain variable region

<400>  106

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  107
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A9 light chain variable region

<400>  107

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Met Ser Leu Gly 
1               5                   10                  15      


Gln Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Asn Asn Gln Leu Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Lys Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Thr Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
                85                  90                  95      


His Phe Asn Thr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  108
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3B1 light chain variable region

<400>  108

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Ile Ser Val Gly 
1               5                   10                  15      


Gln Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Val Phe Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
                85                  90                  95      


His Tyr Ser Ile Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  109
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G5 light chain variable region

<400>  109

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Met Ser Val Gly 
1               5                   10                  15      


Gln Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Val Phe Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Thr Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
                85                  90                  95      


His Tyr Ser Ile Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  110
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3B2 light chain variable region

<400>  110

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Met Ser Val Gly 
1               5                   10                  15      


Gln Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
                85                  90                  95      


His Tyr Ser Ile Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  111
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3B8 light chain variable region

<400>  111

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Met Ser Val Gly 
1               5                   10                  15      


Gln Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
                85                  90                  95      


His Tyr Ser Thr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  112
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G8 light chain variable region

<400>  112

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Met Ser Val Gly 
1               5                   10                  15      


Gln Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
                85                  90                  95      


His Tyr Ser Thr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  113
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F7 light chain variable region

<400>  113

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Met Ser Val Gly 
1               5                   10                  15      


Gln Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
                85                  90                  95      


His Tyr Ser Thr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  114
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E9 light chain variable region

<400>  114

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Met Ser Val Gly 
1               5                   10                  15      


Gln Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Thr Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
                85                  90                  95      


His Tyr Ser Thr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  115
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3C3 light chain variable region

<400>  115

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Met Ser Val Gly 
1               5                   10                  15      


Gln Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Val Tyr Phe Gly Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Gly Val Gln Ala Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
                85                  90                  95      


His Tyr Ser Thr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  116
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E12 light chain variable region

<400>  116

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Met Ser Val Gly 
1               5                   10                  15      


Gln Lys Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Arg 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
                85                  90                  95      


His Tyr Ser Ile Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  117
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4A2 light chain variable region

<400>  117

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Met Ser Val Gly 
1               5                   10                  15      


Gln Lys Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Asn 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Leu Tyr Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Tyr Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
                85                  90                  95      


His Tyr Ser Thr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Asp Leu 
            100                 105                 110         


Lys 
    


<210>  118
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F10 light chain variable region

<400>  118

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Met Ser Val Gly 
1               5                   10                  15      


Gln Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Thr 
            20                  25                  30          


Ser Asn Gln Leu Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Thr Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
                85                  90                  95      


His Tyr Ser Thr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  119
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F4 light chain variable region

<400>  119

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Thr 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Ala Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
                85                  90                  95      


His Tyr Ser Thr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  120
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3B11 light chain variable region

<400>  120

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Met Ser Val Gly 
1               5                   10                  15      


Gln Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
                85                  90                  95      


His Tyr Ser Thr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  121
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G12 light chain variable region

<400>  121

Asp Ile Val Met Thr Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Glu Leu Leu Ile 
        35                  40                  45              


Tyr Trp Thr Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln His Tyr Ser Ile Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Arg 
            100                 105         


<210>  122
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3D1 light chain variable region

<400>  122

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile His Thr Tyr 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Glu Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  123
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3C2 light chain variable region

<400>  123

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Thr Cys Lys Ala Ser Gln Asp Ile His Asn Tyr 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


His Arg Ala Asn Arg Leu Val Ala Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Leu Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Ala Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  124
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E6 light chain variable region

<400>  124

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Thr Cys Lys Ala Ser Gln Asp Ile His Asn Tyr 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


His Arg Ala Asn Arg Leu Val Ala Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Leu Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Ala Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  125
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3H3 light chain variable region

<400>  125

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile His Arg Phe 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Phe His Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Leu Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Phe Cys Leu Gln Tyr Asp Ala Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  126
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A2 heavy chain variable region

<400>  126

His Glu Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Asp 
            20                  25                  30          


Tyr Asn Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Glu Tyr Asn Glu Lys 
    50                  55                  60                  


Phe Lys Gly Arg Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Asp Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Trp Phe Gly Leu Arg Gln Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Thr 
        115 


<210>  127
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F6 heavy chain variable region

<400>  127

His Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Glu 
            20                  25                  30          


Tyr Asn Ile His Trp Val Lys Gln Lys Pro Gly Gln Gly Pro Glu Trp 
        35                  40                  45              


Ile Gly Asn Ile Asn Pro Tyr Asn Asp Val Thr Glu Tyr Asn Glu Lys 
    50                  55                  60                  


Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ala Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Asp Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Trp Gly Leu Arg Asn Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  128
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E8 heavy chain variable region

<400>  128

His Glu Val Gln Leu Gln Gln Ser Val Pro Glu Leu Val Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu 
            20                  25                  30          


Tyr Asn Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Pro Glu Trp 
        35                  40                  45              


Ile Gly Asn Ile Asn Pro Tyr Asn Asn Val Thr Glu Tyr Asn Glu Lys 
    50                  55                  60                  


Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Leu Asp Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Trp Gly Leu Arg Asn Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  129
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A9 heavy chain variable region

<400>  129

His Gln Val Gln Val Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly 
1               5                   10                  15      


Ala Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asp 
            20                  25                  30          


Tyr Glu Val His Trp Val Arg Gln Arg Pro Val His Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Val Ile Asp Pro Glu Thr Gly Asp Thr Ala Tyr Asn Gln Lys 
    50                  55                  60                  


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Glu Leu Ser Ser Leu Thr Ala Glu Asp Ser Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ile Gly Tyr Ala Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  130
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3B1 heavy chain variable region

<400>  130

His Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly 
1               5                   10                  15      


Ala Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp 
            20                  25                  30          


Tyr Glu Ile His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Val Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys 
    50                  55                  60                  


Phe Lys Gly Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
                85                  90                  95      


Cys Met Gly Tyr Ser Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  131
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3B2 heavy chain variable region

<400>  131

His Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly 
1               5                   10                  15      


Ala Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp 
            20                  25                  30          


Tyr Glu Ile His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Val Ile Asp Pro Glu Thr Gly Ala Thr Ala Tyr Asn Gln Lys 
    50                  55                  60                  


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
                85                  90                  95      


Cys Met Gly Tyr Ser Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  132
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F4 heavy chain variable region

<400>  132

His Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly 
1               5                   10                  15      


Ala Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp 
            20                  25                  30          


Tyr Glu Ile His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Val Ile Asp Pro Glu Thr Gly Ser Thr Ala Tyr Asn Gln Lys 
    50                  55                  60                  


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ala Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
                85                  90                  95      


Cys Met Gly Tyr Ser Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  133
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E9 heavy chain variable region

<400>  133

His Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly 
1               5                   10                  15      


Ala Ser Ala Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp 
            20                  25                  30          


Tyr Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Val Ile Asp Pro Glu Thr Gly Ser Thr Ala Tyr Asn Gln Lys 
    50                  55                  60                  


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
                85                  90                  95      


Cys Met Gly Tyr Ala Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  134
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3B8 heavy chain variable region

<400>  134

His Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly 
1               5                   10                  15      


Ala Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp 
            20                  25                  30          


Tyr Glu Ile His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Val Ile Asp Pro Glu Thr Gly Asp Thr Ala Tyr Asn Gln Asn 
    50                  55                  60                  


Phe Thr Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
                85                  90                  95      


Cys Met Gly Tyr Ala Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  135
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G8 heavy chain variable region

<400>  135

His Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Arg Pro Gly 
1               5                   10                  15      


Ala Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp 
            20                  25                  30          


Tyr Glu Val His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Val Ile Asp Pro Ala Thr Gly Asp Thr Ala Tyr Asn Gln Lys 
    50                  55                  60                  


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Glu Val Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
                85                  90                  95      


Cys Met Gly Tyr Ser Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  136
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F7 heavy chain variable region

<400>  136

His Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly 
1               5                   10                  15      


Ala Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp 
            20                  25                  30          


Tyr Glu Ile His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Val Ile Asp Pro Glu Thr Gly Asp Thr Ala Tyr Asn Gln Lys 
    50                  55                  60                  


Phe Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ala Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
                85                  90                  95      


Cys Met Gly Tyr Ser Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  137
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E12 heavy chain variable region

<400>  137

His Gln Val Gln Leu Gln Gln Ser Glu Ala Glu Leu Val Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp 
            20                  25                  30          


Tyr Glu Ile His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Val Ile Asp Pro Glu Thr Gly Asp Thr Ala Tyr Asn Gln Lys 
    50                  55                  60                  


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Glu Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
                85                  90                  95      


Cys Met Gly His Ser Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  138
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G12 heavy chain variable region

<400>  138

His Glu Val Gln Leu Gln Gln Ser Val Ala Glu Leu Val Arg Pro Gly 
1               5                   10                  15      


Ala Ser Val Thr Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asp 
            20                  25                  30          


Tyr Glu Ile His Trp Val Lys Gln Thr Pro Ala His Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Val Ile Asp Pro Glu Thr Gly Asn Thr Ala Phe Asn Gln Lys 
    50                  55                  60                  


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Ile Ser Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
                85                  90                  95      


Cys Met Gly Tyr Ser Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  139
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3F10 heavy chain variable region

<400>  139

His Glu Val Gln Leu Gln Gln Ser Val Ala Glu Leu Val Arg Pro Gly 
1               5                   10                  15      


Ala Pro Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp 
            20                  25                  30          


Tyr Glu Val His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Val Ile Asp Pro Glu Thr Gly Ala Thr Ala Tyr Asn Gln Lys 
    50                  55                  60                  


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Ala Ala 
65                  70                  75                  80  


Tyr Met Glu Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
                85                  90                  95      


Cys Met Ser Tyr Ser Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  140
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3C3 heavy chain variable region

<400>  140

His Glu Val Gln Leu Gln Gln Ser Val Ala Glu Val Val Arg Pro Gly 
1               5                   10                  15      


Ala Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp 
            20                  25                  30          


Tyr Glu Ile His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Val Ile Asp Pro Glu Thr Gly Val Thr Ala Tyr Asn Gln Arg 
    50                  55                  60                  


Phe Arg Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe 
                85                  90                  95      


Cys Met Gly Tyr Ser Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  141
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G5 heavy chain variable region

<400>  141

His Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly 
1               5                   10                  15      


Ala Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp 
            20                  25                  30          


Tyr Glu Ile His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Val Leu Asp Pro Gly Thr Gly Arg Thr Ala Tyr Asn Gln Lys 
    50                  55                  60                  


Phe Lys Asp Lys Ala Thr Leu Ser Ala Asp Lys Ser Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
                85                  90                  95      


Cys Met Ser Tyr Ser Asp Tyr Trp Gly Pro Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  142
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   3B11 heavy chain variable region

<400>  142

His Glu Val Gln Leu Gln Gln Ser Val Ala Glu Leu Val Arg Pro Gly 
1               5                   10                  15      


Ala Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp 
            20                  25                  30          


Tyr Glu Met His Trp Val Lys Gln Thr Pro Val Arg Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Val Ile Asp Pro Ala Thr Gly Asp Thr Ala Tyr Asn Gln Lys 
    50                  55                  60                  


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Ala Ala 
65                  70                  75                  80  


Phe Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
                85                  90                  95      


Cys Met Gly Tyr Ser Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  143
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E6 heavy chain variable region

<400>  143

His Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly 
1               5                   10                  15      


Ala Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asp 
            20                  25                  30          


Tyr Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Gly Ile Asp Pro Glu Thr Gly Asp Thr Val Tyr Asn Gln Lys 
    50                  55                  60                  


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ile Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  144
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4A2 heavy chain variable region

<400>  144

His Gln Val Lys Leu Gln Gln Ser Gly Thr Glu Leu Val Arg Pro Gly 
1               5                   10                  15      


Ala Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Asp 
            20                  25                  30          


Tyr Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Gly Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys 
    50                  55                  60                  


Phe Lys Gly Lys Ala Ile Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala 
65                  70                  75                  80  


Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ile Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  145
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E10 heavy chain variable region

<400>  145

His Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Asp Thr Phe Thr Asp 
            20                  25                  30          


Tyr Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp 
        35                  40                  45              


Ile Gly Asp Ile Asn Pro Asn Tyr Gly Gly Ile Thr Tyr Asn Gln Lys 
    50                  55                  60                  


Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Glu Leu Arg Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
                85                  90                  95      


Cys Gln Ala Tyr Tyr Arg Asn Ser Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  146
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3D1 heavy chain variable region

<400>  146

His Glu Val Gln Leu Gln Glu Ser Gly Pro Asp Leu Val Lys Pro Ser 
1               5                   10                  15      


Gln Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Phe Ser Ile Thr Ser 
            20                  25                  30          


Gly Tyr Gly Trp His Trp Ile Arg Gln Phe Pro Gly Asp Lys Leu Glu 
        35                  40                  45              


Trp Met Gly Tyr Ile Ser Phe Asn Gly Asp Tyr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Phe Leu Gln Leu Ser Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Ser Ser Tyr Asp Gly Leu Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  147
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3C2 heavy chain variable region

<400>  147

His Asp Val Gln Leu Gln Glu Ser Gly Pro Asp Leu Val Lys Pro Ser 
1               5                   10                  15      


Gln Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Phe Ser Ile Thr Ser 
            20                  25                  30          


Gly Tyr Gly Trp His Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu 
        35                  40                  45              


Trp Met Gly Tyr Ile Ser Phe Asn Gly Asp Ser Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Phe Leu Gln Leu Asn Ser Val Thr Ser Glu Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Ser Ser Tyr Asp Gly Leu Phe Ala Tyr Trp Gly Gln Gly Pro 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  148
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A2 light chain CDR1

<400>  148

Lys Ser Ser Gln Ser Leu Leu His Ser Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  149
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A2 light chain CDR2

<400>  149

Leu Val Ser Lys Leu Asp Ser 
1               5           


<210>  150
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A2 light chain CDR3

<400>  150

Trp Gln Gly Thr His Phe Pro Arg Thr 
1               5                   


<210>  151
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A2 heavy chain CDR1

<400>  151

Gly Tyr Thr Phe Thr Asp Tyr Asn Met His 
1               5                   10  


<210>  152
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A2 heavy chain CDR2

<400>  152

Tyr Ile Asn Pro Tyr Asn Asp Val Thr Glu 
1               5                   10  


<210>  153
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A2 heavy chain CDR3

<400>  153

Ala Trp Phe Gly Leu Arg Gln 
1               5           


<210>  154
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E10 light chain CDR1

<400>  154

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  155
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3E10 light chain CDR2

<400>  155

Arg Met Ser Asn Leu Ala Ser 
1               5           


<210>  156
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   3E10 light chain CDR3

<400>  156

Met Gln His Leu Glu Tyr Pro Tyr Thr 
1               5                   


<210>  157
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   3E10 heavy chain CDR1

<400>  157

Gly Asp Thr Phe Thr Asp Tyr Tyr Met Asn 
1               5                   10  


<210>  158
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   3E10 heavy chain CDR2

<400>  158

Asp Ile Asn Pro Asn Tyr Gly Gly Ile Thr 
1               5                   10  


<210>  159
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   3E10 heavy chain CDR3

<400>  159

Gln Ala Tyr Tyr Arg Asn Ser Asp Tyr 
1               5                   


<210>  160
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G12 light chain CDR1

<400>  160

Lys Ala Ser Gln Asp Val Gly Thr Ala Val Ala 
1               5                   10      


<210>  161
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G12 light chain CDR2

<400>  161

Trp Thr Ser Thr Arg His Thr 
1               5           


<210>  162
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G12 light chain CDR3

<400>  162

Gln Gln His Tyr Ser Ile Pro Leu Thr 
1               5                   


<210>  163
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G12 heavy chain CDR1

<400>  163

Gly Tyr Ile Phe Thr Asp Tyr Glu Ile His 
1               5                   10  


<210>  164
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G12 heavy chain CDR2

<400>  164

Val Ile Asp Pro Glu Thr Gly Asn Thr Ala 
1               5                   10  


<210>  165
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3G12 heavy chain CDR3

<400>  165

Met Gly Tyr Ser Asp Tyr 
1               5       


<210>  166
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized 3D3 light chain

<400>  166

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Asn Ser Asn Phe Gln Lys Asn Phe Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Phe Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Ser Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln Gln His Tyr Ser Thr Pro Leu Thr Phe Gly Gln Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


<210>  167
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized 3D3 heavy chain

<400>  167

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe 
        35                  40                  45              


Thr Asp Tyr Glu Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Val Ile Asp Pro Glu Thr Gly Asn Thr Ala Phe Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Met Gly Tyr Ser Asp Tyr Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
225                 230                 235                 240 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        275                 280                 285             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
305                 310                 315                 320 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460         


<210>  168
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized 3D3 light chain variable region

<400>  168

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Asn Phe Gln Lys Asn Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Phe Ala Ser Thr Arg Glu Ser Ser Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


His Tyr Ser Thr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  169
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized 3D3 heavy chain variable region

<400>  169

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asp Tyr 
            20                  25                  30          


Glu Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asp Pro Glu Thr Gly Asn Thr Ala Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Met Gly Tyr Ser Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  170
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized 3C4 light chain

<400>  170

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Ile His Asn Phe Leu Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Thr Leu Ile Phe Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Ser Cys Leu Gln Tyr Asp 
            100                 105                 110         


Glu Ile Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  171
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized 3C4 heavy chain

<400>  171

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Ile 
        35                  40                  45              


Thr Ser Gly Tyr Gly Trp His Trp Ile Arg Gln His Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Tyr Ile Asn Tyr Asp Gly His Asn Asp Tyr Asn 
65                  70                  75                  80  


Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Gln Asp Thr Ser Lys Asn 
                85                  90                  95      


Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Ser Tyr Asp Gly Leu Phe Ala Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
    130                 135                 140                 


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
145                 150                 155                 160 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
                165                 170                 175     


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
        195                 200                 205             


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
    210                 215                 220                 


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
225                 230                 235                 240 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 


Gly Lys 
465     


<210>  172
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized 3C4 light chain variable region

<400>  172

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile His Asn Phe 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Thr Leu Ile 
        35                  40                  45              


Phe Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Ser Cys Leu Gln Tyr Asp Glu Ile Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  173
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized 3C4 heavy chain variable region

<400>  173

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Gly Trp His Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Asn Tyr Asp Gly His Asn Asp Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Gln Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Tyr Asp Gly Leu Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser 
        115     


<210>  174
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 3D3 light chain variable region consensus 1


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:16

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:16

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:16

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:16

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:16

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:16

<220>
<221>  MISC_FEATURE
<222>  (49)..(49)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:16

<220>
<221>  MISC_FEATURE
<222>  (64)..(64)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:16

<220>
<221>  MISC_FEATURE
<222>  (69)..(69)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:16

<220>
<221>  MISC_FEATURE
<222>  (84)..(84)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:16

<220>
<221>  MISC_FEATURE
<222>  (89)..(89)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:16

<220>
<221>  MISC_FEATURE
<222>  (91)..(91)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:16

<220>
<221>  MISC_FEATURE
<222>  (93)..(93)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:16

<220>
<221>  MISC_FEATURE
<222>  (106)..(106)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:16

<220>
<221>  MISC_FEATURE
<222>  (112)..(112)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:16

<400>  174

Asp Ile Val Met Thr Gln Ser Pro Xaa Ser Leu Ala Val Ser Xaa Gly 
1               5                   10                  15      


Xaa Xaa Xaa Thr Xaa Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Asn Phe Gln Lys Asn Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Xaa Pro Lys Leu Leu Ile Tyr Phe Ala Ser Thr Arg Glu Ser Ser Xaa 
    50                  55                  60                  


Pro Asp Arg Phe Xaa Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Xaa Gln Ala Glu Asp Xaa Ala Xaa Tyr Xaa Cys Gln Gln 
                85                  90                  95      


His Tyr Ser Thr Pro Leu Thr Phe Gly Xaa Gly Thr Lys Leu Glu Xaa 
            100                 105                 110         


Lys 
    


<210>  175
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 3D3 light chain variable region consensus 2


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa may be D or S

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa may be an hydrophobic amino acid

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa may be E or Q

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa may be a basic amino acid

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa may be an hydrophobic amino acid

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa may be an hydrophobic amino acid

<220>
<221>  MISC_FEATURE
<222>  (49)..(49)
<223>  Xaa may be P or S

<220>
<221>  MISC_FEATURE
<222>  (64)..(64)
<223>  Xaa may be an hydrophobic amino acid

<220>
<221>  MISC_FEATURE
<222>  (69)..(69)
<223>  Xaa may be S or I

<220>
<221>  MISC_FEATURE
<222>  (84)..(84)
<223>  Xaa may be an hydrophobic amino acid

<220>
<221>  MISC_FEATURE
<222>  (89)..(89)
<223>  Xaa may be an hydrophobic amino acid

<220>
<221>  MISC_FEATURE
<222>  (91)..(91)
<223>  Xaa may be V or D

<220>
<221>  MISC_FEATURE
<222>  (93)..(93)
<223>  Xaa may be an aromatic amino acid

<220>
<221>  MISC_FEATURE
<222>  (106)..(106)
<223>  Xaa may be Q or A

<220>
<221>  MISC_FEATURE
<222>  (112)..(112)
<223>  Xaa may be an hydrophobic amino acid

<400>  175

Asp Ile Val Met Thr Gln Ser Pro Xaa Ser Leu Ala Val Ser Xaa Gly 
1               5                   10                  15      


Xaa Xaa Xaa Thr Xaa Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Asn Phe Gln Lys Asn Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Xaa Pro Lys Leu Leu Ile Tyr Phe Ala Ser Thr Arg Glu Ser Ser Xaa 
    50                  55                  60                  


Pro Asp Arg Phe Xaa Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Xaa Gln Ala Glu Asp Xaa Ala Xaa Tyr Xaa Cys Gln Gln 
                85                  90                  95      


His Tyr Ser Thr Pro Leu Thr Phe Gly Xaa Gly Thr Lys Leu Glu Xaa 
            100                 105                 110         


Lys 
    


<210>  176
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 3D3 light chain variable region consensus 3


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa may be D or S

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa may be L or I

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa may be E or Q

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa may be R or K

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa may be A or V

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa may be I or M

<220>
<221>  MISC_FEATURE
<222>  (49)..(49)
<223>  Xaa may be P or S

<220>
<221>  MISC_FEATURE
<222>  (64)..(64)
<223>  Xaa may be V or I

<220>
<221>  MISC_FEATURE
<222>  (69)..(69)
<223>  Xaa may be S or I

<220>
<221>  MISC_FEATURE
<222>  (84)..(84)
<223>  Xaa may be L or V

<220>
<221>  MISC_FEATURE
<222>  (89)..(89)
<223>  Xaa may be v or L

<220>
<221>  MISC_FEATURE
<222>  (91)..(91)
<223>  Xaa may be V or D

<220>
<221>  MISC_FEATURE
<222>  (93)..(93)
<223>  Xaa may be Y or F

<220>
<221>  MISC_FEATURE
<222>  (106)..(106)
<223>  Xaa may be Q or A

<220>
<221>  MISC_FEATURE
<222>  (112)..(112)
<223>  Xaa may be I or L

<400>  176

Asp Ile Val Met Thr Gln Ser Pro Xaa Ser Leu Ala Val Ser Xaa Gly 
1               5                   10                  15      


Xaa Xaa Xaa Thr Xaa Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Asn Phe Gln Lys Asn Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Xaa Pro Lys Leu Leu Ile Tyr Phe Ala Ser Thr Arg Glu Ser Ser Xaa 
    50                  55                  60                  


Pro Asp Arg Phe Xaa Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Xaa Gln Ala Glu Asp Xaa Ala Xaa Tyr Xaa Cys Gln Gln 
                85                  90                  95      


His Tyr Ser Thr Pro Leu Thr Phe Gly Xaa Gly Thr Lys Leu Glu Xaa 
            100                 105                 110         


Lys 
    


<210>  177
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 3D3 heavy chain variable region consensus 1


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:18

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:18

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:18

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:18

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:18

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:18

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:18

<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:18

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:18

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:18

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:18

<220>
<221>  MISC_FEATURE
<222>  (48)..(48)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:18

<220>
<221>  MISC_FEATURE
<222>  (67)..(67)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:18

<220>
<221>  MISC_FEATURE
<222>  (68)..(68)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:18

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:18

<220>
<221>  MISC_FEATURE
<222>  (74)..(74)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:18

<220>
<221>  MISC_FEATURE
<222>  (76)..(76)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:18

<220>
<221>  MISC_FEATURE
<222>  (91)..(91)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:18

<220>
<221>  MISC_FEATURE
<222>  (108)..(108)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:18

<220>
<221>  MISC_FEATURE
<222>  (109)..(109)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:18

<400>  177

Glu Val Gln Leu Xaa Gln Ser Xaa Ala Glu Xaa Xaa Xaa Pro Gly Ala 
1               5                   10                  15      


Ser Val Xaa Xaa Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asp Tyr 
            20                  25                  30          


Glu Ile His Trp Val Xaa Gln Xaa Pro Xaa Xaa Gly Leu Glu Trp Xaa 
        35                  40                  45              


Gly Val Ile Asp Pro Glu Thr Gly Asn Thr Ala Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Xaa Xaa Thr Xaa Thr Ala Asp Xaa Ser Xaa Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Xaa Ala Val Tyr Tyr Cys 
                85                  90                  95      


Met Gly Tyr Ser Asp Tyr Trp Gly Gln Gly Thr Xaa Xaa Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  178
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 3D3 heavy chain variable region consensus 2


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa may be V or Q

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa may be G or V

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa may be an hydrophobic amino acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa may be K or V

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa may be a basic amino acid

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa may be K or T

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa may be an hydrophobic amino acid

<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  Xaa may be a basic amino acid

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa may be A or T

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  Xaa may be G or V

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  Xaa may be Q or H

<220>
<221>  MISC_FEATURE
<222>  (48)..(48)
<223>  Xaa may be an hydrophobic amino acid

<220>
<221>  MISC_FEATURE
<222>  (67)..(67)
<223>  Xaa may be a basic amino acid

<220>
<221>  MISC_FEATURE
<222>  (68)..(68)
<223>  Xaa may be an hydrophobic amino acid

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  Xaa may be an hydrophobic amino acid

<220>
<221>  MISC_FEATURE
<222>  (74)..(74)
<223>  Xaa may be T or I

<220>
<221>  MISC_FEATURE
<222>  (76)..(76)
<223>  Xaa may be a neutral hydrophilic amino acid

<220>
<221>  MISC_FEATURE
<222>  (91)..(91)
<223>  Xaa may be a neutral hydrophilic amino acid

<220>
<221>  MISC_FEATURE
<222>  (108)..(108)
<223>  Xaa may be L or T

<220>
<221>  MISC_FEATURE
<222>  (109)..(109)
<223>  Xaa may be an hydrophobic amino acid

<400>  178

Glu Val Gln Leu Xaa Gln Ser Xaa Ala Glu Xaa Xaa Xaa Pro Gly Ala 
1               5                   10                  15      


Ser Val Xaa Xaa Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asp Tyr 
            20                  25                  30          


Glu Ile His Trp Val Xaa Gln Xaa Pro Xaa Xaa Gly Leu Glu Trp Xaa 
        35                  40                  45              


Gly Val Ile Asp Pro Glu Thr Gly Asn Thr Ala Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Xaa Xaa Thr Xaa Thr Ala Asp Xaa Ser Xaa Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Xaa Ala Val Tyr Tyr Cys 
                85                  90                  95      


Met Gly Tyr Ser Asp Tyr Trp Gly Gln Gly Thr Xaa Xaa Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  179
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 3D3 heavy chain variable region consensus 3


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa may be V or Q

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa may be G or V

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa may be V or L

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa may be K or V

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa may be K or R

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa may be K or T

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa may be V or L

<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  Xaa may be R or K

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa may be A or T

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  Xaa may be G or V

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  Xaa may be Q or H

<220>
<221>  MISC_FEATURE
<222>  (48)..(48)
<223>  Xaa may be M or I

<220>
<221>  MISC_FEATURE
<222>  (67)..(67)
<223>  Xaa may be R or K

<220>
<221>  MISC_FEATURE
<222>  (68)..(68)
<223>  Xaa may be V or A

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  Xaa may be I or L

<220>
<221>  MISC_FEATURE
<222>  (74)..(74)
<223>  Xaa may be T or I

<220>
<221>  MISC_FEATURE
<222>  (76)..(76)
<223>  Xaa may be T or S

<220>
<221>  MISC_FEATURE
<222>  (91)..(91)
<223>  Xaa may be T or S

<220>
<221>  MISC_FEATURE
<222>  (108)..(108)
<223>  Xaa may be L or T

<220>
<221>  MISC_FEATURE
<222>  (109)..(109)
<223>  Xaa may be V or L

<400>  179

Glu Val Gln Leu Xaa Gln Ser Xaa Ala Glu Xaa Xaa Xaa Pro Gly Ala 
1               5                   10                  15      


Ser Val Xaa Xaa Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asp Tyr 
            20                  25                  30          


Glu Ile His Trp Val Xaa Gln Xaa Pro Xaa Xaa Gly Leu Glu Trp Xaa 
        35                  40                  45              


Gly Val Ile Asp Pro Glu Thr Gly Asn Thr Ala Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Xaa Xaa Thr Xaa Thr Ala Asp Xaa Ser Xaa Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Xaa Ala Val Tyr Tyr Cys 
                85                  90                  95      


Met Gly Tyr Ser Asp Tyr Trp Gly Gln Gly Thr Xaa Xaa Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  180
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 3C4 light chain variable region consensus 1


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:24

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:24

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:24

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:24

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:24

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:24

<220>
<221>  MISC_FEATURE
<222>  (69)..(69)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:24

<220>
<221>  MISC_FEATURE
<222>  (72)..(72)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:24

<220>
<221>  MISC_FEATURE
<222>  (79)..(79)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:24

<220>
<221>  MISC_FEATURE
<222>  (80)..(80)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:24

<220>
<221>  MISC_FEATURE
<222>  (83)..(83)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:24

<220>
<221>  MISC_FEATURE
<222>  (84)..(84)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:24

<220>
<221>  MISC_FEATURE
<222>  (85)..(85)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:24

<220>
<221>  MISC_FEATURE
<222>  (100)..(100)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:24

<220>
<221>  MISC_FEATURE
<222>  (106)..(106)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:24

<220>
<221>  misc_feature
<222>  (107)..(107)
<223>  Xaa can be any naturally occurring amino acid

<400>  180

Asp Ile Val Met Xaa Gln Ser Pro Ser Ser Xaa Xaa Ala Ser Xaa Gly 
1               5                   10                  15      


Xaa Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile His Asn Phe 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Lys Pro Gly Lys Xaa Pro Lys Thr Leu Ile 
        35                  40                  45              


Phe Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Xaa Asp Tyr Xaa Leu Thr Ile Ser Ser Leu Xaa Xaa 
65                  70                  75                  80  


Glu Asp Xaa Xaa Xaa Tyr Ser Cys Leu Gln Tyr Asp Glu Ile Pro Leu 
                85                  90                  95      


Thr Phe Gly Xaa Gly Thr Lys Leu Glu Xaa Xaa 
            100                 105         


<210>  181
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 3C4 light chain variable region consensus 2


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa may be a neutral hydrophilic amino acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa may be an hydrophobic amino acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa may be S or Y

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa may be an hydrophobic amino acid

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa may be an acidic amino acid

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  Xaa may be A or S

<220>
<221>  MISC_FEATURE
<222>  (69)..(69)
<223>  Xaa may be T or Q

<220>
<221>  MISC_FEATURE
<222>  (72)..(72)
<223>  Xaa may be a neutral hydrophilic amino acid

<220>
<221>  MISC_FEATURE
<222>  (79)..(79)
<223>  Xaa may be Q or E

<220>
<221>  MISC_FEATURE
<222>  (80)..(80)
<223>  Xaa may be P or F

<220>
<221>  MISC_FEATURE
<222>  (83)..(83)
<223>  Xaa may be F or L

<220>
<221>  MISC_FEATURE
<222>  (84)..(84)
<223>  Xaa may be A or G

<220>
<221>  MISC_FEATURE
<222>  (85)..(85)
<223>  Xaa may be T or I

<220>
<221>  MISC_FEATURE
<222>  (100)..(100)
<223>  Xaa may be Q or A

<220>
<221>  MISC_FEATURE
<222>  (106)..(106)
<223>  Xaa may be an hydrophobic amino acid

<220>
<221>  MISC_FEATURE
<222>  (107)..(107)
<223>  Xaa may be a basic amino acid

<400>  181

Asp Ile Val Met Xaa Gln Ser Pro Ser Ser Xaa Xaa Ala Ser Xaa Gly 
1               5                   10                  15      


Xaa Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile His Asn Phe 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Lys Pro Gly Lys Xaa Pro Lys Thr Leu Ile 
        35                  40                  45              


Phe Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Xaa Asp Tyr Xaa Leu Thr Ile Ser Ser Leu Xaa Xaa 
65                  70                  75                  80  


Glu Asp Xaa Xaa Xaa Tyr Ser Cys Leu Gln Tyr Asp Glu Ile Pro Leu 
                85                  90                  95      


Thr Phe Gly Xaa Gly Thr Lys Leu Glu Xaa Xaa 
            100                 105         


<210>  182
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 3C4 light chain variable region consensus 3


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa may be T or S

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa may be L or M

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa may be S or Y

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa may be V or L

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa may be D or E

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  Xaa may be A or S

<220>
<221>  MISC_FEATURE
<222>  (69)..(69)
<223>  Xaa may be T or Q

<220>
<221>  MISC_FEATURE
<222>  (72)..(72)
<223>  Xaa may be T or S

<220>
<221>  MISC_FEATURE
<222>  (79)..(79)
<223>  Xaa may be Q or E

<220>
<221>  MISC_FEATURE
<222>  (80)..(80)
<223>  Xaa may be P or F

<220>
<221>  MISC_FEATURE
<222>  (83)..(83)
<223>  Xaa may be F or L

<220>
<221>  MISC_FEATURE
<222>  (84)..(84)
<223>  Xaa may be A or G

<220>
<221>  MISC_FEATURE
<222>  (85)..(85)
<223>  Xaa may be T or I

<220>
<221>  MISC_FEATURE
<222>  (100)..(100)
<223>  Xaa may be Q or A

<220>
<221>  MISC_FEATURE
<222>  (106)..(106)
<223>  Xaa may be I or L

<220>
<221>  MISC_FEATURE
<222>  (107)..(107)
<223>  Xaa may be K or R

<400>  182

Asp Ile Val Met Xaa Gln Ser Pro Ser Ser Xaa Xaa Ala Ser Xaa Gly 
1               5                   10                  15      


Xaa Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile His Asn Phe 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Lys Pro Gly Lys Xaa Pro Lys Thr Leu Ile 
        35                  40                  45              


Phe Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Xaa Asp Tyr Xaa Leu Thr Ile Ser Ser Leu Xaa Xaa 
65                  70                  75                  80  


Glu Asp Xaa Xaa Xaa Tyr Ser Cys Leu Gln Tyr Asp Glu Ile Pro Leu 
                85                  90                  95      


Thr Phe Gly Xaa Gly Thr Lys Leu Glu Xaa Xaa 
            100                 105         


<210>  183
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 3C4 heavy chain variable region consensus 1


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:26

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:26

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:26

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:26

<220>
<221>  MISC_FEATURE
<222>  (44)..(44)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:26

<220>
<221>  MISC_FEATURE
<222>  (45)..(45)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:26

<220>
<221>  MISC_FEATURE
<222>  (49)..(49)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:26

<220>
<221>  MISC_FEATURE
<222>  (68)..(68)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:26

<220>
<221>  MISC_FEATURE
<222>  (69)..(69)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:26

<220>
<221>  MISC_FEATURE
<222>  (71)..(71)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:26

<220>
<221>  MISC_FEATURE
<222>  (80)..(80)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:26

<220>
<221>  MISC_FEATURE
<222>  (82)..(82)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:26

<220>
<221>  MISC_FEATURE
<222>  (84)..(84)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:26

<220>
<221>  MISC_FEATURE
<222>  (88)..(88)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:26

<220>
<221>  MISC_FEATURE
<222>  (89)..(89)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:26

<220>
<221>  MISC_FEATURE
<222>  (93)..(93)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:26

<220>
<221>  MISC_FEATURE
<222>  (117)..(117)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:26

<400>  183

Glu Val Gln Leu Gln Glu Ser Gly Pro Xaa Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Xaa Leu Ser Leu Thr Cys Thr Val Xaa Gly Phe Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Gly Trp His Trp Ile Arg Gln Xaa Pro Gly Xaa Xaa Leu Glu Trp 
        35                  40                  45              


Xaa Gly Tyr Ile Asn Tyr Asp Gly His Asn Asp Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Xaa Xaa Ile Xaa Gln Asp Thr Ser Lys Asn Gln Phe Xaa 
65                  70                  75                  80  


Leu Xaa Leu Xaa Ser Val Thr Xaa Xaa Asp Thr Ala Xaa Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Tyr Asp Gly Leu Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Xaa 
        115         


<210>  184
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 3C4 heavy chain variable region consensus 2


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  xaa may be G or D

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa may be a neutral hydrophilic amino acid

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa may be a neutral hydrophilic amino acid

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa may be H or F

<220>
<221>  MISC_FEATURE
<222>  (44)..(44)
<223>  Xaa may be K or N

<220>
<221>  MISC_FEATURE
<222>  (45)..(45)
<223>  Xaa may be G or K

<220>
<221>  MISC_FEATURE
<222>  (49)..(49)
<223>  Xaa may be an hydrophobic amino acid

<220>
<221>  MISC_FEATURE
<222>  (68)..(68)
<223>  Xaa may be an hydrophobic amino acid

<220>
<221>  MISC_FEATURE
<222>  (69)..(69)
<223>  Xaa may be a neutral hydrophilic amino acid

<220>
<221>  MISC_FEATURE
<222>  (71)..(71)
<223>  Xaa may be a neutral hydrophilic amino acid

<220>
<221>  MISC_FEATURE
<222>  (80)..(80)
<223>  Xaa may be a neutral hydrophilic amino acid

<220>
<221>  MISC_FEATURE
<222>  (82)..(82)
<223>  Xaa may be a basic amino acid

<220>
<221>  MISC_FEATURE
<222>  (84)..(84)
<223>  Xaa may be S or N

<220>
<221>  MISC_FEATURE
<222>  (88)..(88)
<223>  Xaa may be A or T

<220>
<221>  MISC_FEATURE
<222>  (89)..(89)
<223>  Xaa may be A or E

<220>
<221>  MISC_FEATURE
<222>  (93)..(93)
<223>  Xaa may be V or T

<220>
<221>  MISC_FEATURE
<222>  (117)..(117)
<223>  Xaa may be any amino acid, A or absent

<400>  184

Glu Val Gln Leu Gln Glu Ser Gly Pro Xaa Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Xaa Leu Ser Leu Thr Cys Thr Val Xaa Gly Phe Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Gly Trp His Trp Ile Arg Gln Xaa Pro Gly Xaa Xaa Leu Glu Trp 
        35                  40                  45              


Xaa Gly Tyr Ile Asn Tyr Asp Gly His Asn Asp Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Xaa Xaa Ile Xaa Gln Asp Thr Ser Lys Asn Gln Phe Xaa 
65                  70                  75                  80  


Leu Xaa Leu Xaa Ser Val Thr Xaa Xaa Asp Thr Ala Xaa Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Tyr Asp Gly Leu Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Xaa 
        115         


<210>  185
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 3C4 heavy chain variable region consensus 3


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa may be G or D

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa may be T or S

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa may be S or T

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa may be H or F

<220>
<221>  MISC_FEATURE
<222>  (44)..(44)
<223>  Xaa may be K or N

<220>
<221>  MISC_FEATURE
<222>  (45)..(45)
<223>  Xaa may be G or K

<220>
<221>  MISC_FEATURE
<222>  (49)..(49)
<223>  Xaa may be I or M

<220>
<221>  MISC_FEATURE
<222>  (68)..(68)
<223>  Xaa may be V or I

<220>
<221>  MISC_FEATURE
<222>  (69)..(69)
<223>  Xaa may be T or S

<220>
<221>  MISC_FEATURE
<222>  (71)..(71)
<223>  Xaa may be S or T

<220>
<221>  MISC_FEATURE
<222>  (80)..(80)
<223>  Xaa may be S or F

<220>
<221>  MISC_FEATURE
<222>  (82)..(82)
<223>  Xaa may be K or Q

<220>
<221>  MISC_FEATURE
<222>  (84)..(84)
<223>  Xaa may be S or N

<220>
<221>  MISC_FEATURE
<222>  (88)..(88)
<223>  Xaa may be A or T

<220>
<221>  MISC_FEATURE
<222>  (89)..(89)
<223>  Xaa may be A or E

<220>
<221>  MISC_FEATURE
<222>  (93)..(93)
<223>  Xaa may be V or T

<220>
<221>  MISC_FEATURE
<222>  (117)..(117)
<223>  Xaa may be A or absent

<400>  185

Glu Val Gln Leu Gln Glu Ser Gly Pro Xaa Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Xaa Leu Ser Leu Thr Cys Thr Val Xaa Gly Phe Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Gly Trp His Trp Ile Arg Gln Xaa Pro Gly Xaa Xaa Leu Glu Trp 
        35                  40                  45              


Xaa Gly Tyr Ile Asn Tyr Asp Gly His Asn Asp Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Xaa Xaa Ile Xaa Gln Asp Thr Ser Lys Asn Gln Phe Xaa 
65                  70                  75                  80  


Leu Xaa Leu Xaa Ser Val Thr Xaa Xaa Asp Thr Ala Xaa Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Tyr Asp Gly Leu Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Xaa 
        115         


<210>  186
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A4 variant light chain variable region consensus 1


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:48

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:48

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:48

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:48

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:48

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:48

<220>
<221>  MISC_FEATURE
<222>  (50)..(50)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:48

<220>
<221>  MISC_FEATURE
<222>  (88)..(88)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:48

<220>
<221>  MISC_FEATURE
<222>  (105)..(105)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:48

<220>
<221>  MISC_FEATURE
<222>  (108)..(108)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:48

<220>
<221>  MISC_FEATURE
<222>  (111)..(111)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:48

<400>  186

Asp Xaa Val Met Thr Gln Thr Pro Leu Ser Leu Xaa Val Xaa Xaa Gly 
1               5                   10                  15      


Xaa Xaa Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Xaa Leu Leu Ile His Thr Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Xaa Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Xaa Gly Thr Xaa Leu Glu Xaa Lys 
            100                 105                 110         


<210>  187
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A4 variant light chain variable region consensus 2


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa may be an hydrophobic amino acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa may be A or P

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa may be a neutral hydrophilic amino acid

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa may be L or P

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa may be an acidic amino acid

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa may be Q or P

<220>
<221>  MISC_FEATURE
<222>  (50)..(50)
<223>  Xaa may be a basic amino acid

<220>
<221>  MISC_FEATURE
<222>  (88)..(88)
<223>  Xaa may be an hydrophobic amino acid

<220>
<221>  MISC_FEATURE
<222>  (105)..(105)
<223>  Xaa may be A or Q

<220>
<221>  MISC_FEATURE
<222>  (108)..(108)
<223>  Xaa may be a basic amino acid

<220>
<221>  MISC_FEATURE
<222>  (111)..(111)
<223>  Xaa may be an hydrophobic amino acid

<400>  187

Asp Xaa Val Met Thr Gln Thr Pro Leu Ser Leu Xaa Val Xaa Xaa Gly 
1               5                   10                  15      


Xaa Xaa Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Xaa Leu Leu Ile His Thr Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Xaa Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Xaa Gly Thr Xaa Leu Glu Xaa Lys 
            100                 105                 110         


<210>  188
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A4 variant light chain variable region consensus 3


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa may be V or I

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa may be A or P

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa may be S or T

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa may be L or P

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa may be D or E

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa may be Q or P

<220>
<221>  MISC_FEATURE
<222>  (50)..(50)
<223>  Xaa may be K or Q

<220>
<221>  MISC_FEATURE
<222>  (88)..(88)
<223>  Xaa may be L or V

<220>
<221>  MISC_FEATURE
<222>  (105)..(105)
<223>  Xaa may be A or Q

<220>
<221>  MISC_FEATURE
<222>  (108)..(108)
<223>  Xaa may be R or K

<220>
<221>  MISC_FEATURE
<222>  (111)..(111)
<223>  Xaa may be L or I

<400>  188

Asp Xaa Val Met Thr Gln Thr Pro Leu Ser Leu Xaa Val Xaa Xaa Gly 
1               5                   10                  15      


Xaa Xaa Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Xaa Leu Leu Ile His Thr Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Xaa Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Xaa Gly Thr Xaa Leu Glu Xaa Lys 
            100                 105                 110         


<210>  189
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   3A4 variant-1 light chain variable region: Lvh1

<400>  189

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  190
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   3A4 variant-2 light chain variable region: Lvh2

<400>  190

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  191
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   3A4 variant heavy chain variable region consensus 1


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:46

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:46

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:46

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:46

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:46

<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:46

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:46

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:46

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:46

<220>
<221>  MISC_FEATURE
<222>  (44)..(44)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:46

<220>
<221>  MISC_FEATURE
<222>  (48)..(48)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:46

<220>
<221>  MISC_FEATURE
<222>  (67)..(67)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:46

<220>
<221>  MISC_FEATURE
<222>  (68)..(68)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:46

<220>
<221>  MISC_FEATURE
<222>  (69)..(69)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:46

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:46

<220>
<221>  MISC_FEATURE
<222>  (72)..(72)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:46

<220>
<221>  MISC_FEATURE
<222>  (74)..(74)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:46

<220>
<221>  MISC_FEATURE
<222>  (76)..(76)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:46

<220>
<221>  MISC_FEATURE
<222>  (82)..(82)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:46

<220>
<221>  MISC_FEATURE
<222>  (84)..(84)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:46

<220>
<221>  MISC_FEATURE
<222>  (87)..(87)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:46

<220>
<221>  MISC_FEATURE
<222>  (91)..(91)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:46

<220>
<221>  MISC_FEATURE
<222>  (111)..(111)
<223>  Xaa is an amino acid substitution in comparison with SEQ ID 
       NO.:46

<400>  191

Gln Xaa Gln Leu Val Gln Ser Gly Xaa Glu Xaa Xaa Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Xaa Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Asp 
            20                  25                  30          


Tyr Met Ser Trp Val Xaa Gln Xaa Xaa Gly Xaa Xaa Leu Glu Trp Xaa 
        35                  40                  45              


Gly Asp Ile Asn Pro Tyr Asn Gly Asp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Xaa Xaa Xaa Xaa Thr Xaa Asp Xaa Ser Xaa Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Xaa Leu Xaa Ser Leu Xaa Ser Glu Asp Xaa Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Xaa Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  192
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   3A4 variant heavy chain variable region consensus 2


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa may be an hydrophobic amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa may be P or A

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa may be an hydrophobic amino acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa may be V or K

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa may be an hydrophobic amino acid

<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  Xaa may be a basic amino acid

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa may be S or A

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa may be H or P

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  Xaa may be a basic amino acid

<220>
<221>  MISC_FEATURE
<222>  (44)..(44)
<223>  Xaa may be S or G

<220>
<221>  MISC_FEATURE
<222>  (48)..(48)
<223>  Xaa may be an hydrophobic amino acid

<220>
<221>  MISC_FEATURE
<222>  (67)..(67)
<223>  Xaa may be a basic amino acid

<220>
<221>  MISC_FEATURE
<222>  (68)..(68)
<223>  Xaa may be an hydrophobic amino acid

<220>
<221>  MISC_FEATURE
<222>  (69)..(69)
<223>  Xaa may be I or T

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  Xaa may be an hydrophobic amino acid

<220>
<221>  MISC_FEATURE
<222>  (72)..(72)
<223>  Xaa may be an hydrophobic amino acid

<220>
<221>  MISC_FEATURE
<222>  (74)..(74)
<223>  Xaa may be K or T

<220>
<221>  MISC_FEATURE
<222>  (76)..(76)
<223>  Xaa may be a neutral hydrophilic amino acid

<220>
<221>  MISC_FEATURE
<222>  (82)..(82)
<223>  Xaa may be Q or E

<220>
<221>  MISC_FEATURE
<222>  (84)..(84)
<223>  Xaa may be N or S

<220>
<221>  MISC_FEATURE
<222>  (87)..(87)
<223>  Xaa may be T or R

<220>
<221>  MISC_FEATURE
<222>  (91)..(91)
<223>  Xaa may be a neutral hydrophilic amino acid

<220>
<221>  MISC_FEATURE
<222>  (111)..(111)
<223>  Xaa may be S or L

<400>  192

Gln Xaa Gln Leu Val Gln Ser Gly Xaa Glu Xaa Xaa Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Xaa Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Asp 
            20                  25                  30          


Tyr Met Ser Trp Val Xaa Gln Xaa Xaa Gly Xaa Xaa Leu Glu Trp Xaa 
        35                  40                  45              


Gly Asp Ile Asn Pro Tyr Asn Gly Asp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Xaa Xaa Xaa Xaa Thr Xaa Asp Xaa Ser Xaa Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Xaa Leu Xaa Ser Leu Xaa Ser Glu Asp Xaa Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Xaa Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  193
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   3A4 variant heavy chain variable region consensus 3


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa may be I or V

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa may be P or A

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa may be M or V

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa may be V or K

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa may be M or V

<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  Xaa may be K or R

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa may be S or A

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa may be H or P

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  Xaa may be K or Q

<220>
<221>  MISC_FEATURE
<222>  (44)..(44)
<223>  Xaa may be S or G

<220>
<221>  MISC_FEATURE
<222>  (48)..(48)
<223>  Xaa may be I or M

<220>
<221>  MISC_FEATURE
<222>  (67)..(67)
<223>  Xaa may be K or R

<220>
<221>  MISC_FEATURE
<222>  (68)..(68)
<223>  Xaa may be A or V

<220>
<221>  MISC_FEATURE
<222>  (69)..(69)
<223>  Xaa may be I or T

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  Xaa may be L or I

<220>
<221>  MISC_FEATURE
<222>  (72)..(72)
<223>  Xaa may be V or A

<220>
<221>  MISC_FEATURE
<222>  (74)..(74)
<223>  Xaa may be K or T

<220>
<221>  MISC_FEATURE
<222>  (76)..(76)
<223>  Xaa may be S or T

<220>
<221>  MISC_FEATURE
<222>  (82)..(82)
<223>  Xaa may be Q or E

<220>
<221>  MISC_FEATURE
<222>  (84)..(84)
<223>  Xaa may be N or S

<220>
<221>  MISC_FEATURE
<222>  (87)..(87)
<223>  Xaa may be T or R

<220>
<221>  MISC_FEATURE
<222>  (91)..(91)
<223>  Xaa may be S or T

<220>
<221>  MISC_FEATURE
<222>  (111)..(111)
<223>  Xaa may be S or L

<400>  193

Gln Xaa Gln Leu Val Gln Ser Gly Xaa Glu Xaa Xaa Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Xaa Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Asp 
            20                  25                  30          


Tyr Met Ser Trp Val Xaa Gln Xaa Xaa Gly Xaa Xaa Leu Glu Trp Xaa 
        35                  40                  45              


Gly Asp Ile Asn Pro Tyr Asn Gly Asp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Xaa Xaa Xaa Xaa Thr Xaa Asp Xaa Ser Xaa Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Xaa Leu Xaa Ser Leu Xaa Ser Glu Asp Xaa Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Xaa Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  194
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   3A4 variant-1 heavy chain variable region: Hvh1

<400>  194

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Asp 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Asn Pro Tyr Asn Gly Asp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  195
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   3A4 variant-2 heavy chain variable region: Hvh2

<400>  195

Gln Ile Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Asp 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Asn Pro Tyr Asn Gly Asp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  196
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   3A4 variant-3 heavy chain variable region: Hvh3

<400>  196

Gln Ile Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Asp 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Tyr Asn Gly Asp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  197
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   3A4 variant-4 heavy chain variable region: Hvh4

<400>  197

Gln Ile Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Asp 
            20                  25                  30          


Tyr Met Ser Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Tyr Asn Gly Asp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  198
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A4 murine light (kappa) chain

<400>  198

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile His Thr Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Arg Leu Glu Leu Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  199
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A4 humanized ligh (kappa) chain variant 1: Lh1

<400>  199

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  200
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A4 humanized ligh (kappa) chain variant 2: Lh2

<400>  200

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  201
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   3A4 murine heavy (IgG1) chain

<400>  201

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Met Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Asp 
            20                  25                  30          


Tyr Met Ser Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Tyr Asn Gly Asp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Ile Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  202
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A4 humanized heavy (Igg1) chain variant 1: Hh1

<400>  202

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Asp 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Asn Pro Tyr Asn Gly Asp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  203
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A4 humanized heavy (Igg1) chain variant 2: Hh2

<400>  203

Gln Ile Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Asp 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Asn Pro Tyr Asn Gly Asp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  204
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A4 humanized heavy (Igg1) chain variant 3: Hh3

<400>  204

Gln Ile Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Asp 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Tyr Asn Gly Asp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  205
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A4 humanized heavy (Igg1) chain variant 4: Hh4

<400>  205

Gln Ile Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Asp 
            20                  25                  30          


Tyr Met Ser Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Tyr Asn Gly Asp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  206
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  206
atacccaagc ttgccaccat ggagacagac acac                                   34


<210>  207
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  207
atacccaagc ttcatttccc gggagacagg gag                                    33


<210>  208
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  208
atacccaagc ttgggccacc atgaactttc tgctgtcttg g                           41


<210>  209
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  209
atacccaagc ttctaacact ctcccctgtt gaag                                   34


<210>  210
<211>  3962
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid pK-CR5

<400>  210
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtgttgttc cagtttggaa caagagtcca ctattaaaga acgtggactc      180

caacgtcaaa gggcgaaaaa ccgtctatca gggcgatggc ccactacgtg aaccatcacc      240

ctaatcaagt tttttggggt cgaggtgccg taaagcacta aatcggaacc ctaaagggag      300

cccccgattt agagcttgac ggggaaagcc ggcgaacgtg gcgagaaagg aagggaagaa      360

agcgaaagga gcgggcgcta gggcgctggc aagtgtagcg gtcacgctgc gcgtaaccac      420

cacacccgcc gcgcttaatg cgccgctaca gggcgcgtcc cattcgccat tcaggctgcg      480

caactgttgg gaagggcgat cggtgcgggc ctcttcgcta ttacgccagc tggcgaaagg      540

gggatgtgct gcaaggcgat taagttgggt aacgccaggg ttttcccagt cacgacgttg      600

taaaacgacg gccagtgagc gcgcgtaata cgactcacta tagggcgaat tggagctcca      660

ccgcggtggc ggccgctcta gaactagtgg atccacatcg gcgcgccaaa tgatttgccc      720

tcccatatgt ccttccgagt gagagacaca aaaaattcca acacactatt gcaatgaaaa      780

taaatttcct ttattagcca gaggtcgaga tttaaataag cttgctagca gatctttgga      840

cctgggagtg gacacctgtg gagagaaagg caaagtggat gtcattgtca ctcaagtgta      900

tggccagatc gggccaggtg aatatcaaat cctcctcgtt tttggaaact gacaatctta      960

gcgcagaagt aatgcccgct tttgagaggg agtactcacc ccaacagctg gatctcaagc     1020

ctgccacacc tcacctcgac catccgccgt ctcaagaccg cctactttaa ttacatcatc     1080

agcagcacct ccgccagaaa caaccccgac cgccacccgc tgccgcccgc cacggtgctc     1140

agcctacctt gcgactgtga ctggttagac gcctttctcg agaggttttc cgatccggtc     1200

gatgcggact cgctcaggtc cctcggtggc ggagtaccgt tcggaggccg acgggtttcc     1260

gatccaagag tactggaaag accgcgaaga gtttgtcctc aaccgcgagc ccaacagctg     1320

gccctcgcag acagcgatgc ggaagagagt gaccgcggag gctggatcgg tcccggtgtc     1380

ttctatggag gtcaaaacag cgtggatggc gtctccaggc gatctgacgg ttcactaaac     1440

gagctctgct tatataggcc tcccaccgta cacgcctacc tcgacccggg taccaatctt     1500

ataatacaaa cagaccagat tgtctgtttg ttataataca aacagaccag attgtctgtt     1560

tgttataata caaacagacc agattgtctg tttgttataa tacaaacaga ccagattgtc     1620

tgtttgttat aatacaaaca gaccagattg tctgtttgtt ataatacaaa cagaccagat     1680

tgtctgtttg ttaaggttgt cgagtgaaga cgaaagggtt cattaaggcg cgccgtcgac     1740

ctcgaggggg ggcccggtac ccagcttttg ttccctttag tgagggttaa ttgcgcgctt     1800

ggcgtaatca tggtcatagc tgtttcctgt gtgaaattgt tatccgctca caattccaca     1860

caacatacga gccggaagca taaagtgtaa agcctggggt gcctaatgag tgagctaact     1920

cacattaatt gcgttgcgct cactgcccgc tttccagtcg ggaaacctgt cgtgccagct     1980

gcattaatga atcggccaac gcgcggggag aggcggtttg cgtattgggc gctcttccgc     2040

ttcctcgctc actgactcgc tgcgctcggt cgttcggctg cggcgagcgg tatcagctca     2100

ctcaaaggcg gtaatacggt tatccacaga atcaggggat aacgcaggaa agaacatgtg     2160

agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca     2220

taggctccgc ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa     2280

cccgacagga ctataaagat accaggcgtt tccccctgga agctccctcg tgcgctctcc     2340

tgttccgacc ctgccgctta ccggatacct gtccgccttt ctcccttcgg gaagcgtggc     2400

gctttctcat agctcacgct gtaggtatct cagttcggtg taggtcgttc gctccaagct     2460

gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc gccttatccg gtaactatcg     2520

tcttgagtcc aacccggtaa gacacgactt atcgccactg gcagcagcca ctggtaacag     2580

gattagcaga gcgaggtatg taggcggtgc tacagagttc ttgaagtggt ggcctaacta     2640

cggctacact agaaggacag tatttggtat ctgcgctctg ctgaagccag ttaccttcgg     2700

aaaaagagtt ggtagctctt gatccggcaa acaaaccacc gctggtagcg gtggtttttt     2760

tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct caagaagatc ctttgatctt     2820

ttctacgggg tctgacgctc agtggaacga aaactcacgt taagggattt tggtcatgag     2880

attatcaaaa aggatcttca cctagatcct tttaaattaa aaatgaagtt ttaaatcaat     2940

ctaaagtata tatgagtaaa cttggtctga cagttaccaa tgcttaatca gtgaggcacc     3000

tatctcagcg atctgtctat ttcgttcatc catagttgcc tgactccccg tcgtgtagat     3060

aactacgata cgggagggct taccatctgg ccccagtgct gcaatgatac cgcgagaccc     3120

acgctcaccg gctccagatt tatcagcaat aaaccagcca gccggaaggg ccgagcgcag     3180

aagtggtcct gcaactttat ccgcctccat ccagtctatt aattgttgcc gggaagctag     3240

agtaagtagt tcgccagtta atagtttgcg caacgttgtt gccattgcta caggcatcgt     3300

ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc ggttcccaac gatcaaggcg     3360

agttacatga tcccccatgt tgtgcaaaaa agcggttagc tccttcggtc ctccgatcgt     3420

tgtcagaagt aagttggccg cagtgttatc actcatggtt atggcagcac tgcataattc     3480

tcttactgtc atgccatccg taagatgctt ttctgtgact ggtgagtact caaccaagtc     3540

attctgagaa tagtgtatgc ggcgaccgag ttgctcttgc ccggcgtcaa tacgggataa     3600

taccgcgcca catagcagaa ctttaaaagt gctcatcatt ggaaaacgtt cttcggggcg     3660

aaaactctca aggatcttac cgctgttgag atccagttcg atgtaaccca ctcgtgcacc     3720

caactgatct tcagcatctt ttactttcac cagcgtttct gggtgagcaa aaacaggaag     3780

gcaaaatgcc gcaaaaaagg gaataagggc gacacggaaa tgttgaatac tcatactctt     3840

cctttttcaa tattattgaa gcatttatca gggttattgt ctcatgagcg gatacatatt     3900

tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc acatttcccc gaaaagtgcc     3960

ac                                                                    3962


<210>  211
<211>  6530
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid pMPG-CR5

<400>  211
gtcgacgata ccgtgcactt aattaagcgc gctcgaccaa atgatttgcc ctcccatatg       60

tccttccgag tgagagacac aaaaaattcc aacacactat tgcaatgaaa ataaatttcc      120

tttattagcc agaggtcgag gtcgggggat ccgtttaaac ttggacctgg gagtggacac      180

ctgtggagag aaaggcaaag tggatgtcat tgtcactcaa gtgtatggcc agatcgggcc      240

aggtgaatat caaatcctcc tcgtttttgg aaactgacaa tcttagcgca gaagtaatgc      300

ccgcttttga gagggagtac tcaccccaac agctggatct caagcctgcc acacctcacc      360

tcgaccatcc gccgtctcaa gaccgcctac tttaattaca tcatcagcag cacctccgcc      420

agaaacaacc ccgaccgcca cccgctgccg cccgccacgg tgctcagcct accttgcgac      480

tgtgactggt tagacgcctt tctcgagagg ttttccgatc cggtcgatgc ggactcgctc      540

aggtccctcg gtggcggagt accgttcgga ggccgacggg tttccgatcc aagagtactg      600

gaaagaccgc gaagagtttg tcctcaaccg cgagcccaac agctggccct cgcagacagc      660

gatgcggaag agagtgaccg cggaggctgg atcggtcccg gtgtcttcta tggaggtcaa      720

aacagcgtgg atggcgtctc caggcgatct gacggttcac taaacgagct ctgcttatat      780

aggcctccca ccgtacacgc ctacctcgac ccgggtacca atcttataat acaaacagac      840

cagattgtct gtttgttata atacaaacag accagattgt ctgtttgtta taatacaaac      900

agaccagatt gtctgtttgt tataatacaa acagaccaga ttgtctgttt gttataatac      960

aaacagacca gattgtctgt ttgttataat acaaacagac cagattgtct gtttgttaag     1020

gttgtcgagt gaagacgaaa gggttaatta aggcgcgccg tcgactagct tggcacgcca     1080

gaaatccgcg cggtggtttt tgggggtcgg gggtgtttgg cagccacaga cgcccggtgt     1140

tcgtgtcgcg ccagtacatg cggtccatgc ccaggccatc caaaaaccat gggtctgtct     1200

gctcagtcca gtcgtggacc agaccccacg caacgcccaa aataataacc cccacgaacc     1260

ataaaccatt ccccatgggg gaccccgtcc ctaacccacg gggccagtgg ctatggcagg     1320

gcctgccgcc ccgacgttgg ctgcgagccc tgggccttca cccgaacttg gggggtgggg     1380

tggggaaaag gaagaaacgc gggcgtattg gccccaatgg ggtctcggtg gggtatcgac     1440

agagtgccag ccctgggacc gaaccccgcg tttatgaaca aacgacccaa cacccgtgcg     1500

ttttattctg tctttttatt gccgtcatag cgcgggttcc ttccggtatt gtctccttcc     1560

gtgtttcagt tagcctcccc catctcccct attcctttgc cctcggacga gtgctggggc     1620

gtcggtttcc actatcggcg agtacttcta cacagccatc ggtccagacg gccgcgcttc     1680

tgcgggcgat ttgtgtacgc ccgacagtcc cggctccgga tcggacgatt gcgtcgcatc     1740

gaccctgcgc ccaagctgca tcatcgaaat tgccgtcaac caagctctga tagagttggt     1800

caagaccaat gcggagcata tacgcccgga gccgcggcga tcctgcaagc tccggatgcc     1860

tccgctcgaa gtagcgcgtc tgctgctcca tacaagccaa ccacggcctc cagaagaaga     1920

tgttggcgac ctcgtattgg gaatccccga acatcgcctc gctccagtca atgaccgctg     1980

ttatgcggcc attgtccgtc aggacattgt tggagccgaa atccgcgtgc acgaggtgcc     2040

ggacttcggg gcagtcctcg gcccaaagca tcagctcatc gagagcctgc gcgacggacg     2100

cactgacggt gtcgtccatc acagtttgcc agtgatacac atggggatca gcaatcgcgc     2160

atatgaaatc acgccatgta gtgtattgac cgattccttg cggtccgaat gggccgaacc     2220

cgctcgtctg gctaagatcg gccgcagcga tcgcatccat ggcctccgcg accggctgca     2280

gaacagcggg cagttcggtt tcaggcaggt cttgcaacgt gacaccctgt gcacggcggg     2340

agatgcaata ggtcaggctc tcgctgaatt ccccaatgtc aagcacttcc ggaatcggga     2400

gcgcggccga tgcaaagtgc cgataaacat aacgatcttt gtagaaacca tcggcgcagc     2460

tatttacccg caggacatat ccacgccctc ctacatcgaa gctgaaagca cgagattctt     2520

cgccctccga gagctgcatc aggtcggaga cgctgtcgaa cttttcgatc agaaacttct     2580

cgacagacgt cgcggtgagt tcaggctttt tcatatctca ttgcccggga tctgcggcac     2640

gctgttgacg ctgttaagcg ggtcgctgca gggtcgctcg gtgttcgagg ccacacgcgt     2700

caccttaata tgcgaagtgg acctgggacc gcgccgcccc gactgcatct gcgtgttcga     2760

attcgccaat gacaagacgc tgggcggggt ttgtgtcatc atagaactaa agacatgcaa     2820

atatatttct tccggggaca ccgccagcaa acgcgagcaa cgggccacgg ggatgaagca     2880

gggcatggcg gccgacgcgc tgggctacgt cttgctggcg ttcgcgacgc gaggctggat     2940

ggccttcccc attatgattc ttctcgcttc cggcggcatc gggatgcccg cgttgcaggc     3000

catgctgtcc aggcaggtag atgacgacca tcagggacag cttcaaggat cgctcgcggc     3060

tcttaccagc ctaacttcga tcactggacc gctgatcgtc acggcgattt atgccgcctc     3120

ggcgagcaca tggaacgggt tggcatggat tgtaggcgcc gccctatacc ttgtctgcct     3180

ccccgcgttg cgtcgcggtg catggagccg ggccacctcg acctgaatgg aagccggcgg     3240

cacctcgcta acggattcac cactccaaga attggagcca atcaattctt gcggagaact     3300

gtgaatgcgc aaaccaaccc ttggcagaac atatccatcg cgtccgccat ctccagcagc     3360

cgcacgcggc gcagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc     3420

ataggctccg cccccctgac gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa     3480

acccgacagg actataaaga taccaggcgt ttccccctgg aagctccctc gtgcgctctc     3540

ctgttccgac cctgccgctt accggatacc tgtccgcctt tctcccttcg ggaagcgtgg     3600

cgctttctca tagctcacgc tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc     3660

tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc ggtaactatc     3720

gtcttgagtc caacccggta agacacgact tatcgccact ggcagcagcc actggtaaca     3780

ggattagcag agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg tggcctaact     3840

acggctacac tagaaggaca gtatttggta tctgcgctct gctgaagcca gttaccttcg     3900

gaaaaagagt tggtagctct tgatccggca aacaaaccac cgctggtagc ggtggttttt     3960

ttgtttgcaa gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat cctttgatct     4020

tttctacggg gtctgacgct cagtggaacg aaaactcacg ttaagggatt ttggtcatga     4080

gattatcaaa aaggatcttc acctagatcc ttttaaatta aaaatgaagt tttaaatcaa     4140

tctaaagtat atatgagtaa acttggtctg acagttacca atgcttaatc agtgaggcac     4200

ctatctcagc gatctgtcta tttcgttcat ccatagttgc ctgactcccc gtcgtgtaga     4260

taactacgat acgggagggc ttaccatctg gccccagtgc tgcaatgata ccgcgagacc     4320

cacgctcacc ggctccagat ttatcagcaa taaaccagcc agccggaagg gccgagcgca     4380

gaagtggtcc tgcaacttta tccgcctcca tccagtctat taattgttgc cgggaagcta     4440

gagtaagtag ttcgccagtt aatagtttgc gcaacgttgt tgccattgct gcaggcatcg     4500

tggtgtcacg ctcgtcgttt ggtatggctt cattcagctc cggttcccaa cgatcaaggc     4560

gagttacatg atcccccatg ttgtgcaaaa aagcggttag ctccttcggt cctccgatcg     4620

ttgtcagaag taagttggcc gcagtgttat cactcatggt tatggcagca ctgcataatt     4680

ctcttactgt catgccatcc gtaagatgct tttctgtgac tggtgagtac tcaaccaagt     4740

cattctgaga atagtgtatg cggcgaccga gttgctcttg cccggcgtca acacgggata     4800

ataccgcgcc acatagcaga actttaaaag tgctcatcat tggaaaacgt tcttcggggc     4860

gaaaactctc aaggatctta ccgctgttga gatccagttc gatgtaaccc actcgtgcac     4920

ccaactgatc ttcagcatct tttactttca ccagcgtttc tgggtgagca aaaacaggaa     4980

ggcaaaatgc cgcaaaaaag ggaataaggg cgacacggaa atgttgaata ctcatactct     5040

tcctttttca atattattga agcatttatc agggttattg tctcatgagc ggatacatat     5100

ttgaatgtat ttagaaaaat aaacaaatag gggttccgcg cacatttccc cgaaaagtgc     5160

cacctgacgt ctaagaaacc attattatca tgacattaac ctataaaaat aggcgtatca     5220

cgaggccctt tcgtcttcaa gaattctcat gtttgacagc ttatctctag cagatccgga     5280

attcccctcc ccaatttaaa tgaggaccta acctgtggaa atctactgat gtgggaggct     5340

gtaactgtac aaacagaggt tattggaata actagcatgc ttaaccttca tgcagggtca     5400

caaaaagtgc atgacgatgg tggaggaaaa cctattcaag gcagtaattt ccacttcttt     5460

gctgttggtg gagacccctt ggaaatgcag ggagtgctaa tgaattacag gacaaagtac     5520

ccagatggta ctataacccc taaaaaccca acagcccagt cccaggtaat gaatactgac     5580

cataaggcct atttggacaa aaacaatgct tatccagttg agtgctgggt tcctgatcct     5640

agtagaaatg aaaatactag gtattttggg actttcacag gaggggaaaa tgttccccca     5700

gtacttcatg tgaccaacac agctaccaca gtgttgctag atgaacaggg tgtggggcct     5760

ctttgtaaag ctgatagcct gtatgtttca gctgctgata tttgtggcct gtttactaac     5820

agctctggaa cacaacagtg gagaggcctt gcaagatatt ttaagatccg cctgagaaaa     5880

agatctgtaa agaatcctta cctaatttcc tttttgctaa gtgaccttat aaacaggaga     5940

acccagagag tggatgggca gcctatgtat ggtatggaat cccaggtaga agaggttagg     6000

gtgtttgatg gcacagaaag acttccaggg gacccagata tgataagata tattgacaaa     6060

cagggacaat tgcaaaccaa aatgctttaa acaggtgctt ttattgtaca tatacattta     6120

ataaatgctg cttttgtata agccactttt aagcttgtgt tattttgggg gtggtgtttt     6180

aggcctttta aaacactgaa agcctttaca caaatgcaac tcttgactat gggggtctga     6240

cctttgggaa tgttcagcag gggctgaagt atctgagact tgggaagagc attgtgattg     6300

ggattcagtg cttgatccat gtccagagtc ttcagtttct gaatcctctt ctcttgtaat     6360

atcaagaata catttcccca tgcatatatt atatttcatc cttgaaaaag tatacatact     6420

tatctcagaa tccagccttt ccttccattc aacaattcta gaagttaaaa ctggggtaga     6480

tgctattaca gaggtagaat gcttcctaaa cccagaaatg ggggatctgc                6530


<210>  212
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3A4 heavy chain CDR2

<400>  212

Asp Ile Asn Pro Tyr Asn Gly Asp Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  213
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  213
atgccaagtg gtcccaggct gatgttgtga tgacccaaac tcc                         43


<210>  214
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  214
gggaagatga agacagatgg tgcagccaca gtccg                                  35


<210>  215
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  215
gggttccagg ttccactggc cagatccagt tggtgcaatc tgg                         43


<210>  216
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  216
ggggccaggg gaaagacaga tgggcccttc gttgaggc                               38


