                               SEQUENCE LISTING

<110> BOSTON MEDICAL CENTER CORPORATION
 
<120> SLIT-ROBO SIGNALING FOR DIAGNOSIS AND TREATMENT OF KIDNEY DISEASE

<130> 701586-072811-PCT

<140> PCT/US2013/020280
<141> 2013-01-04

<150> 61/583,379
<151> 2012-01-05

<160> 6     

<170> PatentIn version 3.5

<210> 1
<211> 1394
<212> PRT
<213> Homo sapiens

<400> 1
Met Ala Arg Arg His Glu Arg Val Thr Arg Arg Met Trp Thr Trp Ala 
1               5                   10                  15      


Pro Gly Leu Leu Met Met Thr Val Val Phe Trp Gly His Gln Gly Asn 
            20                  25                  30          


Gly Gln Gly Gln Gly Ser Arg Leu Arg Gln Glu Asp Phe Pro Pro Arg 
        35                  40                  45              


Ile Val Glu His Pro Ser Asp Val Ile Val Ser Lys Gly Glu Pro Thr 
    50                  55                  60                  


Thr Leu Asn Cys Lys Ala Glu Gly Arg Pro Thr Pro Thr Ile Glu Trp 
65                  70                  75                  80  


Tyr Lys Asp Gly Glu Arg Val Glu Thr Asp Lys Asp Asp Pro Arg Ser 
                85                  90                  95      


His Arg Met Leu Leu Pro Ser Gly Ser Leu Phe Phe Leu Arg Ile Val 
            100                 105                 110         


His Gly Arg Arg Ser Lys Pro Asp Glu Gly Ser Tyr Val Cys Val Ala 
        115                 120                 125             


Arg Asn Tyr Leu Gly Glu Ala Val Ser Arg Asn Ala Ser Leu Glu Val 
    130                 135                 140                 


Ala Leu Leu Arg Asp Asp Phe Arg Gln Asn Pro Thr Asp Val Val Val 
145                 150                 155                 160 


Ala Ala Gly Glu Pro Ala Ile Leu Glu Cys Gln Pro Pro Arg Gly His 
                165                 170                 175     


Pro Glu Pro Thr Ile Tyr Trp Lys Lys Asp Lys Val Arg Ile Asp Asp 
            180                 185                 190         


Lys Glu Glu Arg Ile Ser Ile Arg Gly Gly Lys Leu Met Ile Ser Asn 
        195                 200                 205             


Thr Arg Lys Ser Asp Ala Gly Met Tyr Thr Cys Val Gly Thr Asn Met 
    210                 215                 220                 


Val Gly Glu Arg Asp Ser Asp Pro Ala Glu Leu Thr Val Phe Glu Arg 
225                 230                 235                 240 


Pro Thr Phe Leu Arg Arg Pro Ile Asn Gln Val Val Leu Glu Glu Glu 
                245                 250                 255     


Ala Val Glu Phe Arg Cys Gln Val Gln Gly Asp Pro Gln Pro Thr Val 
            260                 265                 270         


Arg Trp Lys Lys Asp Asp Ala Asp Leu Pro Arg Gly Arg Tyr Asp Ile 
        275                 280                 285             


Lys Asp Asp Tyr Thr Leu Arg Ile Lys Lys Thr Met Ser Thr Asp Glu 
    290                 295                 300                 


Gly Thr Tyr Met Cys Ile Ala Glu Asn Arg Val Gly Lys Met Glu Ala 
305                 310                 315                 320 


Ser Ala Thr Leu Thr Val Arg Ala Pro Pro Gln Phe Val Val Arg Pro 
                325                 330                 335     


Arg Asp Gln Ile Val Ala Gln Gly Arg Thr Val Thr Phe Pro Cys Glu 
            340                 345                 350         


Thr Lys Gly Asn Pro Gln Pro Ala Val Phe Trp Gln Lys Glu Gly Ser 
        355                 360                 365             


Gln Asn Leu Leu Phe Pro Asn Gln Pro Gln Gln Pro Asn Ser Arg Cys 
    370                 375                 380                 


Ser Val Ser Pro Thr Gly Asp Leu Thr Ile Thr Asn Ile Gln Arg Ser 
385                 390                 395                 400 


Asp Ala Gly Tyr Tyr Ile Cys Gln Ala Leu Thr Val Ala Gly Ser Ile 
                405                 410                 415     


Leu Ala Lys Ala Gln Leu Glu Val Thr Asp Val Leu Thr Asp Arg Pro 
            420                 425                 430         


Pro Pro Ile Ile Leu Gln Gly Pro Ala Asn Gln Thr Leu Ala Val Asp 
        435                 440                 445             


Gly Thr Ala Leu Leu Lys Cys Lys Ala Thr Gly Asp Pro Leu Pro Val 
    450                 455                 460                 


Ile Ser Trp Leu Lys Glu Gly Phe Thr Phe Pro Gly Arg Asp Pro Arg 
465                 470                 475                 480 


Ala Thr Ile Gln Glu Gln Gly Thr Leu Gln Ile Lys Asn Leu Arg Ile 
                485                 490                 495     


Ser Asp Thr Gly Thr Tyr Thr Cys Val Ala Thr Ser Ser Ser Gly Glu 
            500                 505                 510         


Thr Ser Trp Ser Ala Val Leu Asp Val Thr Glu Ser Gly Ala Thr Ile 
        515                 520                 525             


Ser Lys Asn Tyr Asp Leu Ser Asp Leu Pro Gly Pro Pro Ser Lys Pro 
    530                 535                 540                 


Gln Val Thr Asp Val Thr Lys Asn Ser Val Thr Leu Ser Trp Gln Pro 
545                 550                 555                 560 


Gly Thr Pro Gly Thr Leu Pro Ala Ser Ala Tyr Ile Ile Glu Ala Phe 
                565                 570                 575     


Ser Gln Ser Val Ser Asn Ser Trp Gln Thr Val Ala Asn His Val Lys 
            580                 585                 590         


Thr Thr Leu Tyr Thr Val Arg Gly Leu Arg Pro Asn Thr Ile Tyr Leu 
        595                 600                 605             


Phe Met Val Arg Ala Ile Asn Pro Gln Gly Leu Ser Asp Pro Ser Pro 
    610                 615                 620                 


Met Ser Asp Pro Val Arg Thr Gln Asp Ile Ser Pro Pro Ala Gln Gly 
625                 630                 635                 640 


Val Asp His Arg Gln Val Gln Lys Glu Leu Gly Asp Val Leu Val Arg 
                645                 650                 655     


Leu His Asn Pro Val Val Leu Thr Pro Thr Thr Val Gln Val Thr Trp 
            660                 665                 670         


Thr Val Asp Arg Gln Pro Gln Phe Ile Gln Gly Tyr Arg Val Met Tyr 
        675                 680                 685             


Arg Gln Thr Ser Gly Leu Gln Ala Thr Ser Ser Trp Gln Asn Leu Asp 
    690                 695                 700                 


Ala Lys Val Pro Thr Glu Arg Ser Ala Val Leu Val Asn Leu Lys Lys 
705                 710                 715                 720 


Gly Val Thr Tyr Glu Ile Lys Val Arg Pro Tyr Phe Asn Glu Phe Gln 
                725                 730                 735     


Gly Met Asp Ser Glu Ser Lys Thr Val Arg Thr Thr Glu Glu Ala Pro 
            740                 745                 750         


Ser Ala Pro Pro Gln Ser Val Thr Val Leu Thr Val Gly Ser Tyr Asn 
        755                 760                 765             


Ser Thr Ser Ile Ser Val Ser Trp Asp Pro Pro Pro Pro Asp His Gln 
    770                 775                 780                 


Asn Gly Ile Ile Gln Glu Tyr Lys Ile Trp Cys Leu Gly Asn Glu Thr 
785                 790                 795                 800 


Arg Phe His Ile Asn Lys Thr Val Asp Ala Ala Ile Arg Ser Val Ile 
                805                 810                 815     


Ile Gly Gly Leu Phe Pro Gly Ile Gln Tyr Arg Val Glu Val Ala Ala 
            820                 825                 830         


Ser Thr Ser Ala Gly Val Gly Val Lys Ser Glu Pro Gln Pro Ile Ile 
        835                 840                 845             


Ile Gly Arg Arg Asn Glu Val Val Ile Thr Glu Asn Asn Asn Ser Ile 
    850                 855                 860                 


Thr Glu Gln Ile Thr Asp Val Val Lys Gln Pro Ala Phe Ile Ala Gly 
865                 870                 875                 880 


Ile Gly Gly Ala Cys Trp Val Ile Leu Met Gly Phe Ser Ile Trp Leu 
                885                 890                 895     


Tyr Trp Arg Arg Lys Lys Arg Lys Gly Leu Ser Asn Tyr Ala Val Thr 
            900                 905                 910         


Phe Gln Arg Gly Asp Gly Gly Leu Met Ser Asn Gly Ser Arg Pro Gly 
        915                 920                 925             


Leu Leu Asn Ala Gly Asp Pro Ser Tyr Pro Trp Leu Ala Asp Ser Trp 
    930                 935                 940                 


Pro Ala Thr Ser Leu Pro Val Asn Asn Ser Asn Ser Gly Pro Asn Glu 
945                 950                 955                 960 


Ile Gly Asn Phe Gly Arg Gly Asp Val Leu Pro Pro Val Pro Gly Gln 
                965                 970                 975     


Gly Asp Lys Thr Ala Thr Met Leu Ser Asp Gly Ala Ile Tyr Ser Ser 
            980                 985                 990         


Ile Asp Phe Thr Thr Lys Thr Ser  Tyr Asn Ser Ser Ser  Gln Ile Thr 
        995                 1000                 1005             


Gln Ala  Thr Pro Tyr Ala Thr  Thr Gln Ile Leu His  Ser Asn Ser 
    1010                 1015                 1020             


Ile His  Glu Leu Ala Val Asp  Leu Pro Asp Pro Gln  Trp Lys Ser 
    1025                 1030                 1035             


Ser Ile  Gln Gln Lys Thr Asp  Leu Met Gly Phe Gly  Tyr Ser Leu 
    1040                 1045                 1050             


Pro Asp  Gln Asn Lys Gly Asn  Asn Gly Gly Lys Gly  Gly Lys Lys 
    1055                 1060                 1065             


Lys Lys  Asn Lys Asn Ser Ser  Lys Pro Gln Lys Asn  Asn Gly Ser 
    1070                 1075                 1080             


Thr Trp  Ala Asn Val Pro Leu  Pro Pro Pro Pro Val  Gln Pro Leu 
    1085                 1090                 1095             


Pro Gly  Thr Glu Leu Glu His  Tyr Ala Val Glu Gln  Gln Glu Asn 
    1100                 1105                 1110             


Gly Tyr  Asp Ser Asp Ser Trp  Cys Pro Pro Leu Pro  Val Gln Thr 
    1115                 1120                 1125             


Tyr Leu  His Gln Gly Leu Glu  Asp Glu Leu Glu Glu  Asp Asp Asp 
    1130                 1135                 1140             


Arg Val  Pro Thr Pro Pro Val  Arg Gly Val Ala Ser  Ser Pro Ala 
    1145                 1150                 1155             


Ile Ser  Phe Gly Gln Gln Ser  Thr Ala Thr Leu Thr  Pro Ser Pro 
    1160                 1165                 1170             


Arg Glu  Glu Met Gln Pro Met  Leu Gln Ala His Leu  Asp Glu Leu 
    1175                 1180                 1185             


Thr Arg  Ala Tyr Gln Phe Asp  Ile Ala Lys Gln Thr  Trp His Ile 
    1190                 1195                 1200             


Gln Ser  Asn Asn Gln Pro Pro  Gln Pro Pro Val Pro  Pro Leu Gly 
    1205                 1210                 1215             


Tyr Val  Ser Gly Ala Leu Ile  Ser Asp Leu Glu Thr  Asp Val Ala 
    1220                 1225                 1230             


Asp Asp  Asp Ala Asp Asp Glu  Glu Glu Ala Leu Glu  Ile Pro Arg 
    1235                 1240                 1245             


Pro Leu  Arg Ala Leu Asp Gln  Thr Pro Gly Ser Ser  Met Asp Asn 
    1250                 1255                 1260             


Leu Asp  Ser Ser Val Thr Gly  Lys Ala Phe Thr Ser  Ser Gln Arg 
    1265                 1270                 1275             


Pro Arg  Pro Thr Ser Pro Phe  Ser Thr Asp Ser Asn  Thr Ser Ala 
    1280                 1285                 1290             


Ala Leu  Ser Gln Ser Gln Arg  Pro Arg Pro Thr Lys  Lys His Lys 
    1295                 1300                 1305             


Gly Gly  Arg Met Asp Gln Gln  Pro Ala Leu Pro His  Arg Arg Glu 
    1310                 1315                 1320             


Gly Met  Thr Asp Glu Glu Ala  Leu Val Pro Tyr Ser  Lys Pro Ser 
    1325                 1330                 1335             


Phe Pro  Ser Pro Gly Gly His  Ser Ser Ser Gly Thr  Ala Ser Ser 
    1340                 1345                 1350             


Lys Gly  Ser Thr Gly Pro Arg  Lys Thr Glu Val Leu  Arg Ala Gly 
    1355                 1360                 1365             


His Gln  Arg Asn Ala Ser Asp  Leu Leu Asp Ile Gly  Tyr Met Gly 
    1370                 1375                 1380             


Ser Asn  Ser Gln Gly Gln Phe  Thr Gly Glu Leu 
    1385                 1390                 


<210> 2
<211> 8374
<212> DNA
<213> Homo sapiens

<400> 2
gcgctggagg agggaggcgg aaggacagcg ctgcgccacc acccggagga gggagcgcgg       60

tagctgcagg caggggaggg agaggaaaga aaaggaagga cggctcccag acagagagtg      120

ggagaaaccg gggagcagcg ggagcagcag gtccgggggg agctgttccg ctgcgctgcc      180

ctcgttattc acacggacgc tgcggagctt cccagggctg cttccctgtc cccctgggtg      240

gaggctgccg tctaaacctg actccagagt ttaagatgca atggccagaa gacatgaacg      300

tgtcactaga aggatgtgga catgggctcc gggactgttg atgatgactg tggtgttttg      360

gggtcatcag gggaatggac aaggccaagg atcgcgtctt cgccaggagg actttccccc      420

gcggattgtg gagcatcctt ccgatgtcat cgtctctaag ggcgagccca cgactctgaa      480

ctgcaaggcg gagggccggc caacgcccac cattgagtgg tacaaagatg gggagcgagt      540

ggagactgac aaggacgatc cccggtccca caggatgctt ctgcccagcg gatccttatt      600

cttcttgcgc atcgtgcacg ggcgcaggag taaacctgat gaaggaagct acgtttgtgt      660

tgcgaggaac tatcttggtg aagcagtgag tcgaaatgcg tctctggaag tggcattgtt      720

acgagatgac ttccgacaaa accccacaga tgttgtagtg gcagctggag agcctgcaat      780

cctggagtgc cagcctcccc ggggacaccc agaacccacc atctactgga aaaaagacaa      840

agttcgaatt gatgacaagg aagaaagaat aagtatccgt ggtggaaaac tgatgatctc      900

caataccagg aaaagtgatg cagggatgta tacttgtgtt ggtaccaata tggtgggaga      960

aagggacagt gacccagcag agctgactgt ctttgaacga cccacatttc tcaggaggcc     1020

aattaaccag gtggtactgg aggaagaagc tgtagaattt cgttgtcaag tccaaggaga     1080

tcctcaacca actgtgaggt ggaaaaagga tgatgcagac ttgccaagag gaaggtatga     1140

catcaaagac gattacacac taagaattaa aaagaccatg agtacagatg aaggcaccta     1200

tatgtgtatt gctgagaatc gggttggaaa aatggaagcc tctgctacac tcaccgtccg     1260

agctccccca cagtttgtgg ttcggccaag agatcagatt gttgctcaag gtcgaacagt     1320

gacatttccc tgtgaaacta aaggaaaccc acagccagct gttttttggc agaaagaagg     1380

cagccagaac ctacttttcc caaaccaacc ccagcagccc aacagtagat gctcagtgtc     1440

accaactgga gacctcacaa tcaccaacat tcaacgttcc gacgcgggtt actacatctg     1500

ccaggcttta actgtggcag gaagcatttt agcaaaagct caactggagg ttactgatgt     1560

tttgacagat agacctccac ctataattct acaaggccca gccaaccaaa cgctggcagt     1620

ggatggtaca gcgttactga aatgtaaagc cactggtgat cctcttcctg taattagctg     1680

gttaaaggag ggatttactt ttccgggtag agatccaaga gcaacaattc aagagcaagg     1740

cacactgcag attaagaatt tacggatttc tgatactggc acttatactt gtgtggctac     1800

aagttcaagt ggagagactt cctggagtgc agtgctggat gtgacagagt ctggagcaac     1860

aatcagtaaa aactatgatt taagtgacct gccagggcca ccatccaaac cgcaggtcac     1920

tgatgttact aagaacagtg tcaccttgtc ctggcagcca ggtacccctg gaacccttcc     1980

agcaagtgca tatatcattg aggctttcag ccaatcagtg agcaacagct ggcagaccgt     2040

ggcaaaccat gtaaagacca ccctctatac tgtaagagga ctgcggccca atacaatcta     2100

cttattcatg gtcagagcga tcaaccccca aggtctcagt gacccaagtc ccatgtcaga     2160

tcctgtgcgc acacaagata tcagcccacc agcacaagga gtggaccaca ggcaagtgca     2220

gaaagagcta ggagatgtcc ttgtccgtct tcataatcca gttgtgctga ctcccaccac     2280

ggttcaggtc acatggacgg ttgatcgcca accccagttt atccaaggct accgagtgat     2340

gtatcgtcag acttcaggtc tgcaggcgac atcttcgtgg cagaatttag atgccaaagt     2400

cccgactgaa cgaagtgctg tcttagtcaa cctgaaaaag ggggtgactt atgaaattaa     2460

agtacggcca tattttaatg agttccaagg aatggatagt gaatctaaaa cggttcgtac     2520

tactgaagaa gccccaagtg ccccaccaca gtctgtcact gtactgacag ttggaagcta     2580

caatagcaca agtattagtg tttcctggga tcctcctcct ccagatcacc agaatggaat     2640

tatccaagaa tacaagatct ggtgtctagg aaatgaaacg cgattccata tcaacaaaac     2700

tgtggatgca gccattcggt ccgtaataat tggtggatta ttcccaggta ttcaataccg     2760

ggtagaggtt gcagctagta ccagtgcagg ggttggagta aagagtgagc cacagccaat     2820

aataatcggg agacgcaatg aagttgtcat tactgaaaac aataacagca taactgagca     2880

aatcactgat gtggtgaagc aaccagcctt tatagctggt attggtggtg cctgctgggt     2940

aattctgatg ggttttagca tatggttgta ttggcgaaga aagaagagga agggactcag     3000

taattatgct gttacgtttc aaagaggaga tggaggacta atgagcaatg gaagccgtcc     3060

aggtcttctc aatgctggtg atcccagcta tccatggctt gctgattctt ggccagccac     3120

gagcttgcca gtaaataata gcaacagtgg cccaaatgag attggaaatt ttggccgtgg     3180

agatgtgctg ccaccagttc caggccaagg ggataaaaca gcaacgatgc tctcagatgg     3240

agccatttat agtagcattg acttcactac caaaaccagt tacaacagtt ccagccaaat     3300

aacacaggct accccatatg ccacgacaca gatcttgcat tccaacagca tacatgaatt     3360

ggctgtcgat ctgcctgatc cacaatggaa aagctcaatt cagcaaaaaa cagatctgat     3420

gggatttggt tattctctac ctgatcagaa caaaggtaac aatggtggga aaggtggaaa     3480

aaagaagaaa aataaaaact cttctaaacc acagaaaaac aatggatcca cttgggccaa     3540

tgtccctcta cctccccccc cagtccagcc ccttcctggc acggagctgg aacactatgc     3600

agtggaacaa caagaaaatg gctatgacag tgatagctgg tgcccaccat tgccagtaca     3660

aacttactta caccaaggtc tggaagatga actggaagaa gatgatgata gggtcccaac     3720

acctcctgtt cgaggcgtgg cttcttctcc tgctatctcc tttggacagc agtccactgc     3780

aactcttact ccatccccac gggaagagat gcaacccatg ctgcaggctc acctggatga     3840

gttgacaaga gcctatcagt ttgatatagc aaaacaaaca tggcacattc aaagcaataa     3900

tcaacctcca cagcctccag ttccaccgtt aggttatgtg tctggagcct tgatttctga     3960

tttggaaacg gatgttgcag atgatgatgc cgacgacgaa gaggaagctt tagaaatccc     4020

caggcccctg agagcactgg accagactcc tggatccagc atggacaatc tagacagctc     4080

tgtgacagga aaagccttta cctcctctca aagacctcga cctaccagcc cattttctac     4140

tgacagtaac accagtgcag ccctgagtca aagtcagagg cctcggccca ctaaaaaaca     4200

caagggaggg cggatggacc aacaaccagc attgcctcat cgaagggaag gaatgacaga     4260

tgaggaggcc ttggtgccct atagcaagcc cagtttccca tctccaggtg gccacagctc     4320

atcaggaaca gcttcttcta agggatccac tggacctagg aaaaccgagg tgttgagagc     4380

aggccaccag cgcaatgcca gcgaccttct tgacatagga tatatgggct ccaacagtca     4440

aggacagttt acaggtgaat tatagtaaat gagaggagac atacaaagct gctctgaagg     4500

accatcaggt ccggactcat ggaagtgatg actctaaaca gtgcaatgaa caatttattt     4560

atgtactatt aaaagaactg taaatgcaat gtaaagacac acagccacac atatcccaca     4620

gatattttca ttgtgttctt ctcttaagta caccacccac cttaactctt tcttgtcagg     4680

agtatataaa aaagaaagaa aacaaaactc gccctacagg aagaaaagga ttctcctctg     4740

tatataattt cttttgtgca ttgctatgca agctcactct ttttagctct gctcatatta     4800

ttgtctgttc ttattggtct gttgtactat atgtgaatta ataggctgtg gtgccatata     4860

ttaactttta attgtgtaac ttttatgttt aaattttgca ctgcaatttt atttggtgat     4920

aagcacaaat ctctactcct catgacatga agaaaaagac tgaatgtgaa gggagtttct     4980

gtactgtaag ctagattgga taatgatggc tgtaacaaat catgttagat ggttttcagt     5040

tggggtgtag aaataggaag atgcaaagga acaatggtgt tggcaaagtc ttctttgaat     5100

atcagggact gagtcaataa aaaaaatagt agaaaggtgg cttttactat tgacaaaagc     5160

cggggtcaaa aaaagtagtt taagtcttaa gactgaatat gcattaaagt atgcaggtag     5220

caaagatgta ataaatttgc ttaaaaaaag aaattaaagt tttatttaga atcaatttta     5280

cctgtcattg taattgaccc atctgagaat tacaataagc aagaggaaat taaggtgttt     5340

tgcaagagct gtatttatat tacagttttt taaaaacatt ttctgaatta tcgtaattaa     5400

gctctccaac tcgttaagtc agaatataat atgaagttcc ccaaggaaac gaacaaaatg     5460

aactctagaa tatctagcaa atagttaaag aagcaattta ttattagggc atactcgggc     5520

tgtttccaaa tataaactct attgcaatat cttatttcat ctttctaata catgtacagt     5580

gcacactaga ggatagagct gcatcactta aattcatgac ttaaaaaata atacagttta     5640

tatacaactt gttttttatt tgattaagaa gtgaagttta cgccacccaa tgtatagcca     5700

aattgtacgt gcttaaaaaa cagtgccgag agtatgttca gttcgcagta agtagattta     5760

ttggaataaa tattctatgg tacattctca gaaattggct tccaactaaa atacgtttga     5820

cccattttga ataaggaaat tgaaaagaaa aatttaaaag gagaaaaaaa tgcatgttta     5880

taaacttttt aaataaaacc agaccttgta agtggacatt aataattgtc ctgcctcatt     5940

tgttttcacg actttgacaa caagaagttc ctgaacatta gtcatgtatg ctcagaataa     6000

atgtgacttt gaaatatatg ttagctactg tacatgtata gtcagtcaag tagaagagga     6060

ccttcctgaa attcccactt gtgacatttt cccatgggtt tcctacacaa tcttaaattt     6120

tatttctgtc tatactttct caaatttttc ctatgataag ttcagttgtt ggtactcttc     6180

taaaaatatt caacgtgatt aggatcagtt ctaaaatacg ggaccccttt gagtgacaat     6240

tcgcactcca tgcattattg gctcagtagc caatttttgt cacgtcgtta taacaaggag     6300

atgacataat taaacatttc catcctttct attccctgag actgcatcag cacaggcaag     6360

tatagaatgt aatgttcttc atgggcccca ccagcttttt ggtgccatgt aatttatttc     6420

ttcgctgaag agaaaaagaa ttctgagaca cagttattaa accctttatc aactttctac     6480

catcagtgcc tgaattctaa tgcagtgtga tttctctggg acaaagagac tgaggaagat     6540

gaaaagtttc ttcaaagagt gaatacatac ttattcacaa ctctaggatg tgaggacttt     6600

aaatatctct ttatgaagtt ccctgcctaa cctctttcta tttaaaggca aacaaatttc     6660

gaagaggttt tgtgttccct ctttatgttt ctctatgacc cagtttagtc taaaacctta     6720

gttcattaca tatacaacac atagcctttg atccctggta actggcaggt gttggtgatt     6780

aataaaccaa ggcttcaaag tgaagtatgt gtgtgcagat gacttttgga ataacgtggg     6840

catagcatca taccttcctg attgtcttca gcatataaaa attaactgtt gtagttaaaa     6900

ttatgtcagt gcagagcttg tggttacttg gaatgttctt tcagaatagt ccatgttgcc     6960

tattaaacct agttttaaac acattgggca gtcaatttat gcacccaaaa tatcaccctc     7020

aggtagattg agggcaagat aaaatgctgt atgtagctat acaaaggaat tcagaaacat     7080

tactggaaag caaagccttt gtcagcttgc tactgacaaa gtagtaaaaa gctactaatc     7140

agtgttgagt cagatgtcaa cagaaaaata caaataccta tgagagccac agcagtttct     7200

cgtttcatag ccgattcaat gaatatgatt agaaattcac tgagctcact cttgcaggtt     7260

taaatggagg cctgcataag gactgcaaga ggaaatctgg gtgggagaga atgtaatctg     7320

atcttgcact cataggcaat gctgcaatgc aatcatgtcc aatacaagca cagcttcatt     7380

cataacagga aacgtcttct ttgggaaaat agctctattg gtgcccaaac tcaggtatgc     7440

cagtgtatgc aggtggagtc gccctacccc tcttccaaac atgtcctgtg agatttttaa     7500

aataagatgg gatagtacag gggcatgaaa agaattgatt ccttcacagg atttgaatcc     7560

agttcaaggg agaatgtaga aaattcaaaa ccaacatata aggtatcaca caaccaagaa     7620

aagtaaaacc attgcaagtt tacttgcgtt gagtacaaaa cagatttaat ggtgttctat     7680

gtcatagttt aatgctctgg gtatttaaat atgttttcaa caggatttga gttgaaagtt     7740

tgtaatgtgc tttgatggaa cacctctcaa tttctattca ataaacttat gtaattgtcc     7800

attgacaata taatgataac agtaccattg aactctaaac tgtggtttat cttcactact     7860

gggaagcaac tgtgcatcag tattaaagat atgcagaaac ataatattca ctaatttgtt     7920

catctgcttc tgtatattgt ttatggaatt acatggcaag aactgttcta aagcaacatg     7980

tctttccaca ttattttaga ggtgaaatta cttttgtttt gcttctctat aatgtgtact     8040

tcaaatgaaa caccatactt ttttctaaaa aaagatgttc aatttactaa tttttttaaa     8100

tctcataatt taaaaagcat ttgttgtgat tttaaagtgt tgcaagaaaa gggattttgt     8160

ggccgtgggt agacttttta tactttgttt tatagatgga ttttttttaa ctgtagtttg     8220

tttaagtcac caagcagcat ccaaaatctt aatgtgtttc atttgatgtt gttagatcag     8280

agaagaaatt ggcataaaat cggttaatag tattgtcaaa gaattgtgta ttgtgtactc     8340

actgggaaaa aataaaatat attcacattt caaa                                 8374


<210> 3
<211> 1378
<212> PRT
<213> Homo sapiens

<400> 3
Met Ser Leu Leu Met Phe Thr Gln Leu Leu Leu Cys Gly Phe Leu Tyr 
1               5                   10                  15      


Val Arg Val Asp Gly Ser Arg Leu Arg Gln Glu Asp Phe Pro Pro Arg 
            20                  25                  30          


Ile Val Glu His Pro Ser Asp Val Ile Val Ser Lys Gly Glu Pro Thr 
        35                  40                  45              


Thr Leu Asn Cys Lys Ala Glu Gly Arg Pro Thr Pro Thr Ile Glu Trp 
    50                  55                  60                  


Tyr Lys Asp Gly Glu Arg Val Glu Thr Asp Lys Asp Asp Pro Arg Ser 
65                  70                  75                  80  


His Arg Met Leu Leu Pro Ser Gly Ser Leu Phe Phe Leu Arg Ile Val 
                85                  90                  95      


His Gly Arg Arg Ser Lys Pro Asp Glu Gly Ser Tyr Val Cys Val Ala 
            100                 105                 110         


Arg Asn Tyr Leu Gly Glu Ala Val Ser Arg Asn Ala Ser Leu Glu Val 
        115                 120                 125             


Ala Leu Leu Arg Asp Asp Phe Arg Gln Asn Pro Thr Asp Val Val Val 
    130                 135                 140                 


Ala Ala Gly Glu Pro Ala Ile Leu Glu Cys Gln Pro Pro Arg Gly His 
145                 150                 155                 160 


Pro Glu Pro Thr Ile Tyr Trp Lys Lys Asp Lys Val Arg Ile Asp Asp 
                165                 170                 175     


Lys Glu Glu Arg Ile Ser Ile Arg Gly Gly Lys Leu Met Ile Ser Asn 
            180                 185                 190         


Thr Arg Lys Ser Asp Ala Gly Met Tyr Thr Cys Val Gly Thr Asn Met 
        195                 200                 205             


Val Gly Glu Arg Asp Ser Asp Pro Ala Glu Leu Thr Val Phe Glu Arg 
    210                 215                 220                 


Pro Thr Phe Leu Arg Arg Pro Ile Asn Gln Val Val Leu Glu Glu Glu 
225                 230                 235                 240 


Ala Val Glu Phe Arg Cys Gln Val Gln Gly Asp Pro Gln Pro Thr Val 
                245                 250                 255     


Arg Trp Lys Lys Asp Asp Ala Asp Leu Pro Arg Gly Arg Tyr Asp Ile 
            260                 265                 270         


Lys Asp Asp Tyr Thr Leu Arg Ile Lys Lys Thr Met Ser Thr Asp Glu 
        275                 280                 285             


Gly Thr Tyr Met Cys Ile Ala Glu Asn Arg Val Gly Lys Met Glu Ala 
    290                 295                 300                 


Ser Ala Thr Leu Thr Val Arg Ala Pro Pro Gln Phe Val Val Arg Pro 
305                 310                 315                 320 


Arg Asp Gln Ile Val Ala Gln Gly Arg Thr Val Thr Phe Pro Cys Glu 
                325                 330                 335     


Thr Lys Gly Asn Pro Gln Pro Ala Val Phe Trp Gln Lys Glu Gly Ser 
            340                 345                 350         


Gln Asn Leu Leu Phe Pro Asn Gln Pro Gln Gln Pro Asn Ser Arg Cys 
        355                 360                 365             


Ser Val Ser Pro Thr Gly Asp Leu Thr Ile Thr Asn Ile Gln Arg Ser 
    370                 375                 380                 


Asp Ala Gly Tyr Tyr Ile Cys Gln Ala Leu Thr Val Ala Gly Ser Ile 
385                 390                 395                 400 


Leu Ala Lys Ala Gln Leu Glu Val Thr Asp Val Leu Thr Asp Arg Pro 
                405                 410                 415     


Pro Pro Ile Ile Leu Gln Gly Pro Ala Asn Gln Thr Leu Ala Val Asp 
            420                 425                 430         


Gly Thr Ala Leu Leu Lys Cys Lys Ala Thr Gly Asp Pro Leu Pro Val 
        435                 440                 445             


Ile Ser Trp Leu Lys Glu Gly Phe Thr Phe Pro Gly Arg Asp Pro Arg 
    450                 455                 460                 


Ala Thr Ile Gln Glu Gln Gly Thr Leu Gln Ile Lys Asn Leu Arg Ile 
465                 470                 475                 480 


Ser Asp Thr Gly Thr Tyr Thr Cys Val Ala Thr Ser Ser Ser Gly Glu 
                485                 490                 495     


Thr Ser Trp Ser Ala Val Leu Asp Val Thr Glu Ser Gly Ala Thr Ile 
            500                 505                 510         


Ser Lys Asn Tyr Asp Leu Ser Asp Leu Pro Gly Pro Pro Ser Lys Pro 
        515                 520                 525             


Gln Val Thr Asp Val Thr Lys Asn Ser Val Thr Leu Ser Trp Gln Pro 
    530                 535                 540                 


Gly Thr Pro Gly Thr Leu Pro Ala Ser Ala Tyr Ile Ile Glu Ala Phe 
545                 550                 555                 560 


Ser Gln Ser Val Ser Asn Ser Trp Gln Thr Val Ala Asn His Val Lys 
                565                 570                 575     


Thr Thr Leu Tyr Thr Val Arg Gly Leu Arg Pro Asn Thr Ile Tyr Leu 
            580                 585                 590         


Phe Met Val Arg Ala Ile Asn Pro Gln Gly Leu Ser Asp Pro Ser Pro 
        595                 600                 605             


Met Ser Asp Pro Val Arg Thr Gln Asp Ile Ser Pro Pro Ala Gln Gly 
    610                 615                 620                 


Val Asp His Arg Gln Val Gln Lys Glu Leu Gly Asp Val Leu Val Arg 
625                 630                 635                 640 


Leu His Asn Pro Val Val Leu Thr Pro Thr Thr Val Gln Val Thr Trp 
                645                 650                 655     


Thr Val Asp Arg Gln Pro Gln Phe Ile Gln Gly Tyr Arg Val Met Tyr 
            660                 665                 670         


Arg Gln Thr Ser Gly Leu Gln Ala Thr Ser Ser Trp Gln Asn Leu Asp 
        675                 680                 685             


Ala Lys Val Pro Thr Glu Arg Ser Ala Val Leu Val Asn Leu Lys Lys 
    690                 695                 700                 


Gly Val Thr Tyr Glu Ile Lys Val Arg Pro Tyr Phe Asn Glu Phe Gln 
705                 710                 715                 720 


Gly Met Asp Ser Glu Ser Lys Thr Val Arg Thr Thr Glu Glu Ala Pro 
                725                 730                 735     


Ser Ala Pro Pro Gln Ser Val Thr Val Leu Thr Val Gly Ser Tyr Asn 
            740                 745                 750         


Ser Thr Ser Ile Ser Val Ser Trp Asp Pro Pro Pro Pro Asp His Gln 
        755                 760                 765             


Asn Gly Ile Ile Gln Glu Tyr Lys Ile Trp Cys Leu Gly Asn Glu Thr 
    770                 775                 780                 


Arg Phe His Ile Asn Lys Thr Val Asp Ala Ala Ile Arg Ser Val Ile 
785                 790                 795                 800 


Ile Gly Gly Leu Phe Pro Gly Ile Gln Tyr Arg Val Glu Val Ala Ala 
                805                 810                 815     


Ser Thr Ser Ala Gly Val Gly Val Lys Ser Glu Pro Gln Pro Ile Ile 
            820                 825                 830         


Ile Gly Arg Arg Asn Glu Val Val Ile Thr Glu Asn Asn Asn Ser Ile 
        835                 840                 845             


Thr Glu Gln Ile Thr Asp Val Val Lys Gln Pro Ala Phe Ile Ala Gly 
    850                 855                 860                 


Ile Gly Gly Ala Cys Trp Val Ile Leu Met Gly Phe Ser Ile Trp Leu 
865                 870                 875                 880 


Tyr Trp Arg Arg Lys Lys Arg Lys Gly Leu Ser Asn Tyr Ala Val Thr 
                885                 890                 895     


Phe Gln Arg Gly Asp Gly Gly Leu Met Ser Asn Gly Ser Arg Pro Gly 
            900                 905                 910         


Leu Leu Asn Ala Gly Asp Pro Ser Tyr Pro Trp Leu Ala Asp Ser Trp 
        915                 920                 925             


Pro Ala Thr Ser Leu Pro Val Asn Asn Ser Asn Ser Gly Pro Asn Glu 
    930                 935                 940                 


Ile Gly Asn Phe Gly Arg Gly Asp Val Leu Pro Pro Val Pro Gly Gln 
945                 950                 955                 960 


Gly Asp Lys Thr Ala Thr Met Leu Ser Asp Gly Ala Ile Tyr Ser Ser 
                965                 970                 975     


Ile Asp Phe Thr Thr Lys Thr Ser Tyr Asn Ser Ser Ser Gln Ile Thr 
            980                 985                 990         


Gln Ala Thr Pro Tyr Ala Thr Thr  Gln Ile Leu His Ser  Asn Ser Ile 
        995                 1000                 1005             


His Glu  Leu Ala Val Asp Leu  Pro Asp Pro Gln Trp  Lys Ser Ser 
    1010                 1015                 1020             


Ile Gln  Gln Lys Thr Asp Leu  Met Gly Phe Gly Tyr  Ser Leu Pro 
    1025                 1030                 1035             


Asp Gln  Asn Lys Gly Asn Asn  Gly Gly Lys Gly Gly  Lys Lys Lys 
    1040                 1045                 1050             


Lys Asn  Lys Asn Ser Ser Lys  Pro Gln Lys Asn Asn  Gly Ser Thr 
    1055                 1060                 1065             


Trp Ala  Asn Val Pro Leu Pro  Pro Pro Pro Val Gln  Pro Leu Pro 
    1070                 1075                 1080             


Gly Thr  Glu Leu Glu His Tyr  Ala Val Glu Gln Gln  Glu Asn Gly 
    1085                 1090                 1095             


Tyr Asp  Ser Asp Ser Trp Cys  Pro Pro Leu Pro Val  Gln Thr Tyr 
    1100                 1105                 1110             


Leu His  Gln Gly Leu Glu Asp  Glu Leu Glu Glu Asp  Asp Asp Arg 
    1115                 1120                 1125             


Val Pro  Thr Pro Pro Val Arg  Gly Val Ala Ser Ser  Pro Ala Ile 
    1130                 1135                 1140             


Ser Phe  Gly Gln Gln Ser Thr  Ala Thr Leu Thr Pro  Ser Pro Arg 
    1145                 1150                 1155             


Glu Glu  Met Gln Pro Met Leu  Gln Ala His Leu Asp  Glu Leu Thr 
    1160                 1165                 1170             


Arg Ala  Tyr Gln Phe Asp Ile  Ala Lys Gln Thr Trp  His Ile Gln 
    1175                 1180                 1185             


Ser Asn  Asn Gln Pro Pro Gln  Pro Pro Val Pro Pro  Leu Gly Tyr 
    1190                 1195                 1200             


Val Ser  Gly Ala Leu Ile Ser  Asp Leu Glu Thr Asp  Val Ala Asp 
    1205                 1210                 1215             


Asp Asp  Ala Asp Asp Glu Glu  Glu Ala Leu Glu Ile  Pro Arg Pro 
    1220                 1225                 1230             


Leu Arg  Ala Leu Asp Gln Thr  Pro Gly Ser Ser Met  Asp Asn Leu 
    1235                 1240                 1245             


Asp Ser  Ser Val Thr Gly Lys  Ala Phe Thr Ser Ser  Gln Arg Pro 
    1250                 1255                 1260             


Arg Pro  Thr Ser Pro Phe Ser  Thr Asp Ser Asn Thr  Ser Ala Ala 
    1265                 1270                 1275             


Leu Ser  Gln Ser Gln Arg Pro  Arg Pro Thr Lys Lys  His Lys Gly 
    1280                 1285                 1290             


Gly Arg  Met Asp Gln Gln Pro  Ala Leu Pro His Arg  Arg Glu Gly 
    1295                 1300                 1305             


Met Thr  Asp Glu Glu Ala Leu  Val Pro Tyr Ser Lys  Pro Ser Phe 
    1310                 1315                 1320             


Pro Ser  Pro Gly Gly His Ser  Ser Ser Gly Thr Ala  Ser Ser Lys 
    1325                 1330                 1335             


Gly Ser  Thr Gly Pro Arg Lys  Thr Glu Val Leu Arg  Ala Gly His 
    1340                 1345                 1350             


Gln Arg  Asn Ala Ser Asp Leu  Leu Asp Ile Gly Tyr  Met Gly Ser 
    1355                 1360                 1365             


Asn Ser  Gln Gly Gln Phe Thr  Gly Glu Leu 
    1370                 1375             


<210> 4
<211> 8689
<212> DNA
<213> Homo sapiens

<400> 4
ctcctctctt ttggaaaccg gagaggtgga gggagggcaa caccgctgca aaggagaggc       60

ccgccaagtc tgcccgcctg caaagtgttg ctttgacaca ttcttattat ggaagttaag      120

taaaaatata gacatattaa aaaataactc cggacgtgga gctgctacgg agaaggaaac      180

cgggggaaag aaaaccagta ggcaggccaa tggtttttcg gcagcgcgct ggcaagtttg      240

tggaacactt tctaggaatt aggtcttttc ctcccccttc atcatcttga cttctgaagg      300

aagaacttgg ctttggattg cagtggagcc taaggagaga gggttagaca cactcgaata      360

atccctctgg ctgggctgaa tttgtgggaa tttaggaagc cagagtgctg gaaatacagc      420

agcctttgaa gtaccctctg ttaatttgga tggatctcag tgtgccccgt tcgagacctc      480

tccaccaacc ccttctgatc ttgcgatttg ctcttcttga ctttaattag tatctaggaa      540

agtctaaact ttggacctac ctcttttttt gatactcatt tttgtacttt tgctctctgg      600

gattggtttc ttaaagaatc tggatccttt ttaatatgtc aaaatgagtc tgctgatgtt      660

tacacaacta ctgctctgtg gatttttata tgttcgggtt gatggatcgc gtcttcgcca      720

ggaggacttt cccccgcgga ttgtggagca tccttccgat gtcatcgtct ctaagggcga      780

gcccacgact ctgaactgca aggcggaggg ccggccaacg cccaccattg agtggtacaa      840

agatggggag cgagtggaga ctgacaagga cgatccccgg tcccacagga tgcttctgcc      900

cagcggatcc ttattcttct tgcgcatcgt gcacgggcgc aggagtaaac ctgatgaagg      960

aagctacgtt tgtgttgcga ggaactatct tggtgaagca gtgagtcgaa atgcgtctct     1020

ggaagtggca ttgttacgag atgacttccg acaaaacccc acagatgttg tagtggcagc     1080

tggagagcct gcaatcctgg agtgccagcc tccccgggga cacccagaac ccaccatcta     1140

ctggaaaaaa gacaaagttc gaattgatga caaggaagaa agaataagta tccgtggtgg     1200

aaaactgatg atctccaata ccaggaaaag tgatgcaggg atgtatactt gtgttggtac     1260

caatatggtg ggagaaaggg acagtgaccc agcagagctg actgtctttg aacgacccac     1320

atttctcagg aggccaatta accaggtggt actggaggaa gaagctgtag aatttcgttg     1380

tcaagtccaa ggagatcctc aaccaactgt gaggtggaaa aaggatgatg cagacttgcc     1440

aagaggaagg tatgacatca aagacgatta cacactaaga attaaaaaga ccatgagtac     1500

agatgaaggc acctatatgt gtattgctga gaatcgggtt ggaaaaatgg aagcctctgc     1560

tacactcacc gtccgagctc ccccacagtt tgtggttcgg ccaagagatc agattgttgc     1620

tcaaggtcga acagtgacat ttccctgtga aactaaagga aacccacagc cagctgtttt     1680

ttggcagaaa gaaggcagcc agaacctact tttcccaaac caaccccagc agcccaacag     1740

tagatgctca gtgtcaccaa ctggagacct cacaatcacc aacattcaac gttccgacgc     1800

gggttactac atctgccagg ctttaactgt ggcaggaagc attttagcaa aagctcaact     1860

ggaggttact gatgttttga cagatagacc tccacctata attctacaag gcccagccaa     1920

ccaaacgctg gcagtggatg gtacagcgtt actgaaatgt aaagccactg gtgatcctct     1980

tcctgtaatt agctggttaa aggagggatt tacttttccg ggtagagatc caagagcaac     2040

aattcaagag caaggcacac tgcagattaa gaatttacgg atttctgata ctggcactta     2100

tacttgtgtg gctacaagtt caagtggaga gacttcctgg agtgcagtgc tggatgtgac     2160

agagtctgga gcaacaatca gtaaaaacta tgatttaagt gacctgccag ggccaccatc     2220

caaaccgcag gtcactgatg ttactaagaa cagtgtcacc ttgtcctggc agccaggtac     2280

ccctggaacc cttccagcaa gtgcatatat cattgaggct ttcagccaat cagtgagcaa     2340

cagctggcag accgtggcaa accatgtaaa gaccaccctc tatactgtaa gaggactgcg     2400

gcccaataca atctacttat tcatggtcag agcgatcaac ccccaaggtc tcagtgaccc     2460

aagtcccatg tcagatcctg tgcgcacaca agatatcagc ccaccagcac aaggagtgga     2520

ccacaggcaa gtgcagaaag agctaggaga tgtccttgtc cgtcttcata atccagttgt     2580

gctgactccc accacggttc aggtcacatg gacggttgat cgccaacccc agtttatcca     2640

aggctaccga gtgatgtatc gtcagacttc aggtctgcag gcgacatctt cgtggcagaa     2700

tttagatgcc aaagtcccga ctgaacgaag tgctgtctta gtcaacctga aaaagggggt     2760

gacttatgaa attaaagtac ggccatattt taatgagttc caaggaatgg atagtgaatc     2820

taaaacggtt cgtactactg aagaagcccc aagtgcccca ccacagtctg tcactgtact     2880

gacagttgga agctacaata gcacaagtat tagtgtttcc tgggatcctc ctcctccaga     2940

tcaccagaat ggaattatcc aagaatacaa gatctggtgt ctaggaaatg aaacgcgatt     3000

ccatatcaac aaaactgtgg atgcagccat tcggtccgta ataattggtg gattattccc     3060

aggtattcaa taccgggtag aggttgcagc tagtaccagt gcaggggttg gagtaaagag     3120

tgagccacag ccaataataa tcgggagacg caatgaagtt gtcattactg aaaacaataa     3180

cagcataact gagcaaatca ctgatgtggt gaagcaacca gcctttatag ctggtattgg     3240

tggtgcctgc tgggtaattc tgatgggttt tagcatatgg ttgtattggc gaagaaagaa     3300

gaggaaggga ctcagtaatt atgctgttac gtttcaaaga ggagatggag gactaatgag     3360

caatggaagc cgtccaggtc ttctcaatgc tggtgatccc agctatccat ggcttgctga     3420

ttcttggcca gccacgagct tgccagtaaa taatagcaac agtggcccaa atgagattgg     3480

aaattttggc cgtggagatg tgctgccacc agttccaggc caaggggata aaacagcaac     3540

gatgctctca gatggagcca tttatagtag cattgacttc actaccaaaa ccagttacaa     3600

cagttccagc caaataacac aggctacccc atatgccacg acacagatct tgcattccaa     3660

cagcatacat gaattggctg tcgatctgcc tgatccacaa tggaaaagct caattcagca     3720

aaaaacagat ctgatgggat ttggttattc tctacctgat cagaacaaag gtaacaatgg     3780

tgggaaaggt ggaaaaaaga agaaaaataa aaactcttct aaaccacaga aaaacaatgg     3840

atccacttgg gccaatgtcc ctctacctcc ccccccagtc cagccccttc ctggcacgga     3900

gctggaacac tatgcagtgg aacaacaaga aaatggctat gacagtgata gctggtgccc     3960

accattgcca gtacaaactt acttacacca aggtctggaa gatgaactgg aagaagatga     4020

tgatagggtc ccaacacctc ctgttcgagg cgtggcttct tctcctgcta tctcctttgg     4080

acagcagtcc actgcaactc ttactccatc cccacgggaa gagatgcaac ccatgctgca     4140

ggctcacctg gatgagttga caagagccta tcagtttgat atagcaaaac aaacatggca     4200

cattcaaagc aataatcaac ctccacagcc tccagttcca ccgttaggtt atgtgtctgg     4260

agccttgatt tctgatttgg aaacggatgt tgcagatgat gatgccgacg acgaagagga     4320

agctttagaa atccccaggc ccctgagagc actggaccag actcctggat ccagcatgga     4380

caatctagac agctctgtga caggaaaagc ctttacctcc tctcaaagac ctcgacctac     4440

cagcccattt tctactgaca gtaacaccag tgcagccctg agtcaaagtc agaggcctcg     4500

gcccactaaa aaacacaagg gagggcggat ggaccaacaa ccagcattgc ctcatcgaag     4560

ggaaggaatg acagatgagg aggccttggt gccctatagc aagcccagtt tcccatctcc     4620

aggtggccac agctcatcag gaacagcttc ttctaaggga tccactggac ctaggaaaac     4680

cgaggtgttg agagcaggcc accagcgcaa tgccagcgac cttcttgaca taggatatat     4740

gggctccaac agtcaaggac agtttacagg tgaattatag taaatgagag gagacataca     4800

aagctgctct gaaggaccat caggtccgga ctcatggaag tgatgactct aaacagtgca     4860

atgaacaatt tatttatgta ctattaaaag aactgtaaat gcaatgtaaa gacacacagc     4920

cacacatatc ccacagatat tttcattgtg ttcttctctt aagtacacca cccaccttaa     4980

ctctttcttg tcaggagtat ataaaaaaga aagaaaacaa aactcgccct acaggaagaa     5040

aaggattctc ctctgtatat aatttctttt gtgcattgct atgcaagctc actcttttta     5100

gctctgctca tattattgtc tgttcttatt ggtctgttgt actatatgtg aattaatagg     5160

ctgtggtgcc atatattaac ttttaattgt gtaactttta tgtttaaatt ttgcactgca     5220

attttatttg gtgataagca caaatctcta ctcctcatga catgaagaaa aagactgaat     5280

gtgaagggag tttctgtact gtaagctaga ttggataatg atggctgtaa caaatcatgt     5340

tagatggttt tcagttgggg tgtagaaata ggaagatgca aaggaacaat ggtgttggca     5400

aagtcttctt tgaatatcag ggactgagtc aataaaaaaa atagtagaaa ggtggctttt     5460

actattgaca aaagccgggg tcaaaaaaag tagtttaagt cttaagactg aatatgcatt     5520

aaagtatgca ggtagcaaag atgtaataaa tttgcttaaa aaaagaaatt aaagttttat     5580

ttagaatcaa ttttacctgt cattgtaatt gacccatctg agaattacaa taagcaagag     5640

gaaattaagg tgttttgcaa gagctgtatt tatattacag ttttttaaaa acattttctg     5700

aattatcgta attaagctct ccaactcgtt aagtcagaat ataatatgaa gttccccaag     5760

gaaacgaaca aaatgaactc tagaatatct agcaaatagt taaagaagca atttattatt     5820

agggcatact cgggctgttt ccaaatataa actctattgc aatatcttat ttcatctttc     5880

taatacatgt acagtgcaca ctagaggata gagctgcatc acttaaattc atgacttaaa     5940

aaataataca gtttatatac aacttgtttt ttatttgatt aagaagtgaa gtttacgcca     6000

cccaatgtat agccaaattg tacgtgctta aaaaacagtg ccgagagtat gttcagttcg     6060

cagtaagtag atttattgga ataaatattc tatggtacat tctcagaaat tggcttccaa     6120

ctaaaatacg tttgacccat tttgaataag gaaattgaaa agaaaaattt aaaaggagaa     6180

aaaaatgcat gtttataaac tttttaaata aaaccagacc ttgtaagtgg acattaataa     6240

ttgtcctgcc tcatttgttt tcacgacttt gacaacaaga agttcctgaa cattagtcat     6300

gtatgctcag aataaatgtg actttgaaat atatgttagc tactgtacat gtatagtcag     6360

tcaagtagaa gaggaccttc ctgaaattcc cacttgtgac attttcccat gggtttccta     6420

cacaatctta aattttattt ctgtctatac tttctcaaat ttttcctatg ataagttcag     6480

ttgttggtac tcttctaaaa atattcaacg tgattaggat cagttctaaa atacgggacc     6540

cctttgagtg acaattcgca ctccatgcat tattggctca gtagccaatt tttgtcacgt     6600

cgttataaca aggagatgac ataattaaac atttccatcc tttctattcc ctgagactgc     6660

atcagcacag gcaagtatag aatgtaatgt tcttcatggg ccccaccagc tttttggtgc     6720

catgtaattt atttcttcgc tgaagagaaa aagaattctg agacacagtt attaaaccct     6780

ttatcaactt tctaccatca gtgcctgaat tctaatgcag tgtgatttct ctgggacaaa     6840

gagactgagg aagatgaaaa gtttcttcaa agagtgaata catacttatt cacaactcta     6900

ggatgtgagg actttaaata tctctttatg aagttccctg cctaacctct ttctatttaa     6960

aggcaaacaa atttcgaaga ggttttgtgt tccctcttta tgtttctcta tgacccagtt     7020

tagtctaaaa ccttagttca ttacatatac aacacatagc ctttgatccc tggtaactgg     7080

caggtgttgg tgattaataa accaaggctt caaagtgaag tatgtgtgtg cagatgactt     7140

ttggaataac gtgggcatag catcatacct tcctgattgt cttcagcata taaaaattaa     7200

ctgttgtagt taaaattatg tcagtgcaga gcttgtggtt acttggaatg ttctttcaga     7260

atagtccatg ttgcctatta aacctagttt taaacacatt gggcagtcaa tttatgcacc     7320

caaaatatca ccctcaggta gattgagggc aagataaaat gctgtatgta gctatacaaa     7380

ggaattcaga aacattactg gaaagcaaag cctttgtcag cttgctactg acaaagtagt     7440

aaaaagctac taatcagtgt tgagtcagat gtcaacagaa aaatacaaat acctatgaga     7500

gccacagcag tttctcgttt catagccgat tcaatgaata tgattagaaa ttcactgagc     7560

tcactcttgc aggtttaaat ggaggcctgc ataaggactg caagaggaaa tctgggtggg     7620

agagaatgta atctgatctt gcactcatag gcaatgctgc aatgcaatca tgtccaatac     7680

aagcacagct tcattcataa caggaaacgt cttctttggg aaaatagctc tattggtgcc     7740

caaactcagg tatgccagtg tatgcaggtg gagtcgccct acccctcttc caaacatgtc     7800

ctgtgagatt tttaaaataa gatgggatag tacaggggca tgaaaagaat tgattccttc     7860

acaggatttg aatccagttc aagggagaat gtagaaaatt caaaaccaac atataaggta     7920

tcacacaacc aagaaaagta aaaccattgc aagtttactt gcgttgagta caaaacagat     7980

ttaatggtgt tctatgtcat agtttaatgc tctgggtatt taaatatgtt ttcaacagga     8040

tttgagttga aagtttgtaa tgtgctttga tggaacacct ctcaatttct attcaataaa     8100

cttatgtaat tgtccattga caatataatg ataacagtac cattgaactc taaactgtgg     8160

tttatcttca ctactgggaa gcaactgtgc atcagtatta aagatatgca gaaacataat     8220

attcactaat ttgttcatct gcttctgtat attgtttatg gaattacatg gcaagaactg     8280

ttctaaagca acatgtcttt ccacattatt ttagaggtga aattactttt gttttgcttc     8340

tctataatgt gtacttcaaa tgaaacacca tacttttttc taaaaaaaga tgttcaattt     8400

actaattttt ttaaatctca taatttaaaa agcatttgtt gtgattttaa agtgttgcaa     8460

gaaaagggat tttgtggccg tgggtagact ttttatactt tgttttatag atggattttt     8520

tttaactgta gtttgtttaa gtcaccaagc agcatccaaa atcttaatgt gtttcatttg     8580

atgttgttag atcagagaag aaattggcat aaaatcggtt aatagtattg tcaaagaatt     8640

gtgtattgtg tactcactgg gaaaaaataa aatatattca catttcaaa                 8689


<210> 5
<211> 216
<212> PRT
<213> Homo sapiens

<400> 5
Thr Glu Leu Glu His Tyr Ala Val Glu Gln Gln Glu Asn Gly Tyr Asp 
1               5                   10                  15      


Ser Asp Ser Trp Cys Pro Pro Leu Pro Val Gln Thr Tyr Leu His Gln 
            20                  25                  30          


Gly Leu Glu Asp Glu Leu Glu Glu Asp Asp Asp Arg Val Pro Thr Pro 
        35                  40                  45              


Pro Val Arg Gly Val Ala Ser Ser Pro Ala Ile Ser Phe Gly Gln Gln 
    50                  55                  60                  


Ser Thr Ala Thr Leu Thr Pro Ser Pro Arg Glu Glu Met Gln Pro Met 
65                  70                  75                  80  


Leu Gln Ala His Leu Asp Glu Leu Thr Arg Ala Tyr Gln Phe Asp Ile 
                85                  90                  95      


Ala Lys Gln Thr Trp His Ile Gln Ser Asn Asn Gln Pro Pro Gln Pro 
            100                 105                 110         


Pro Val Pro Pro Leu Gly Tyr Val Ser Gly Ala Leu Ile Ser Asp Leu 
        115                 120                 125             


Glu Thr Asp Val Ala Asp Asp Asp Ala Asp Asp Glu Glu Glu Ala Leu 
    130                 135                 140                 


Glu Ile Pro Arg Pro Leu Arg Ala Leu Asp Gln Thr Pro Gly Ser Ser 
145                 150                 155                 160 


Met Asp Asn Leu Asp Ser Ser Val Thr Gly Lys Ala Phe Thr Ser Ser 
                165                 170                 175     


Gln Arg Pro Arg Pro Thr Ser Pro Phe Ser Thr Asp Ser Asn Thr Ser 
            180                 185                 190         


Ala Ala Leu Ser Gln Ser Gln Arg Pro Arg Pro Thr Lys His Lys Gly 
        195                 200                 205             


Gly Arg Met Asp Gln Gln Pro Ala 
    210                 215     


<210> 6
<211> 217
<212> PRT
<213> Homo sapiens

<400> 6
Thr Glu Leu Glu His Tyr Ala Val Glu Gln Gln Glu Asn Gly Tyr Asp 
1               5                   10                  15      


Ser Asp Ser Trp Cys Pro Pro Leu Pro Val Gln Thr Tyr Leu His Gln 
            20                  25                  30          


Gly Leu Glu Asp Glu Leu Glu Glu Asp Asp Asp Arg Val Pro Thr Pro 
        35                  40                  45              


Pro Val Arg Gly Val Ala Ser Ser Pro Ala Ile Ser Phe Gly Gln Gln 
    50                  55                  60                  


Ser Thr Ala Thr Leu Thr Pro Ser Pro Arg Glu Glu Met Gln Pro Met 
65                  70                  75                  80  


Leu Gln Ala His Leu Asp Glu Leu Thr Arg Ala Tyr Gln Phe Asp Ile 
                85                  90                  95      


Ala Lys Gln Thr Trp His Ile Gln Ser Asn Asn Gln Pro Pro Gln Pro 
            100                 105                 110         


Pro Val Pro Pro Leu Gly Tyr Val Ser Gly Ala Leu Ile Ser Asp Leu 
        115                 120                 125             


Glu Thr Asp Val Ala Asp Asp Asp Ala Asp Asp Glu Glu Glu Ala Leu 
    130                 135                 140                 


Glu Ile Pro Arg Pro Leu Arg Ala Leu Asp Gln Thr Pro Gly Ser Ser 
145                 150                 155                 160 


Met Asp Asn Leu Asp Ser Ser Val Thr Gly Lys Ala Phe Thr Ser Ser 
                165                 170                 175     


Gln Arg Pro Arg Pro Thr Ser Pro Phe Ser Thr Asp Ser Asn Thr Ser 
            180                 185                 190         


Ala Ala Leu Ser Gln Ser Gln Arg Pro Arg Pro Thr Lys Lys His Lys 
        195                 200                 205             


Gly Gly Arg Met Asp Gln Gln Pro Ala 
    210                 215         


