                         SEQUENCE LISTING

<110>  Quark Pharmaceuticals, Inc.
       ERLICH, Shai
       THOMPSON, James D.
       OZDEN, Rabia
 
<120>  METHODS FOR TREATING EYE DISORDERS

<130>  243/PCT1

<160>  8     

<170>  PatentIn version 3.3

<210>  1
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  1
gccagaaugu ggaacuccu                                                  19


<210>  2
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  2
aggaguucca cauucuggc                                                  19


<210>  3
<211>  4242
<212>  RNA
<213>  Homo_sapiens

<300>
<308>  NM_032982
<309>  2012-12-23
<313>  (1)..(4242)

<400>  3
cuuuugucug uccgccgagc accccacuuc accccauugg accgcgcggc cgccgcuaga     60

gcucugcgcc ugcgcacgca ccgggccggg gacugggugg ccuggugugu gggcgcggca    120

gggcgcaggc gcaggcgcag ugugcguccg cgucugaggg gagggaugug ggggaagcga    180

cggcccccgg uuuguuuggg cugugggcgg ugcgcagcgg agagcccggg aaaagcggga    240

aauggcggcg ccgagcgcgg ggucuugguc caccuuccag cacaaggagc ugauggccgc    300

ugacagggga cgcaggauau ugggagugug uggcaugcau ccucaucauc aggaaacucu    360

aaaaaagaac cgaguggugc uagccaaaca gcuguuguug agcgaauugu uagaacaucu    420

ucuggagaag gacaucauca ccuuggaaau gagggagcuc auccaggcca aagugggcag    480

uuucagccag aauguggaac uccucaacuu gcugccuaag aggggucccc aagcuuuuga    540

ugccuucugu gaagcacuga gggagaccaa gcaaggccac cuggaggaua uguugcucac    600

cacccuuucu gggcuucagc auguacuccc accguugagc ugugacuacg acuugagucu    660

cccuuuuccg gugugugagu ccuguccccu uuacaagaag cuccgccugu cgacagauac    720

uguggaacac ucccuagaca auaaagaugg uccugucugc cuucagguga agccuugcac    780

uccugaauuu uaucaaacac acuuccagcu ggcauauagg uugcagucuc ggccucgugg    840

ccuagcacug guguugagca augugcacuu cacuggagag aaagaacugg aauuucgcuc    900

uggaggggau guggaccaca guacucuagu cacccucuuc aagcuuuugg gcuaugacgu    960

ccauguucua ugugaccaga cugcacagga aaugcaagag aaacugcaga auuuugcaca   1020

guuaccugca caccgaguca cggacuccug caucguggca cuccucucgc auggugugga   1080

gggcgccauc uauggugugg augggaaacu gcuccagcuc caagagguuu uucagcucuu   1140

ugacaacgcc aacugcccaa gccuacagaa caaaccaaaa auguucuuca uccaggccug   1200

ccguggagau gagacugauc gugggguuga ccaacaagau ggaaagaacc acgcaggauc   1260

cccugggugc gaggagagug augccgguaa agaaaaguug ccgaagauga gacugcccac   1320

gcgcucagac augauaugcg gcuaugccug ccucaaaggg acugccgcca ugcggaacac   1380

caaacgaggu uccugguaca ucgaggcucu ugcucaagug uuuucugagc gggcuuguga   1440

uaugcacgug gccgacaugc ugguuaaggu gaacgcacuu aucaaggauc gggaagguua   1500

ugcuccuggc acagaauucc accggugcaa ggagaugucu gaauacugca gcacucugug   1560

ccgccaccuc uaccuguucc caggacaccc ucccacauga ugucaccucc ccaucaucca   1620

cgccaagugg aagccacugg accacaggag gugugauaga gccuuugauc uucaggaugc   1680

acgguuucug uucugccccc ucagggaugu gggaaucucc cagacuuguu uccugugccc   1740

aucaucucug ccuuugagug ugggacucca ggccagcucc uuuucuguga agcccuuugc   1800

cuguagagcc agccuugguu ggaccuauug ccaggaaugu uucagcugca guugaagagc   1860

cugacaagug aaguuguaaa cacagugugg uuauggggag agggcauaua aauuccccau   1920

auuuguguuc aguuccagcu uuuguagaug gcacuuuagu gauugcuuuu auuacauuag   1980

uuaagauguc ugagagacca ucuccuaucu uuuauuucau ucauauccuc cgcccuuuuu   2040

guccuagagu gagaguuugg aaggugucca aauuuaaugu agacauuauc uuuuggcucu   2100

gaagaagcaa acaugacuag agacgcaccu ugcugcagug uccagaagcg gccugugcgu   2160

ucccuucagu acugcagcgc cacccagugg aaggacacuc uuggcucguu ugggcucaag   2220

gcaccgcagc cugucagcca acauugccuu gcauuuguac cuuauugauc uuugcccaug   2280

gaagucucaa agaucuuucg uugguuguuu cucugagcuu uguuacugaa augagccucg   2340

uggggagcau cagagaaggc caggaagaau gguguguuuc ccuagacucu guaaccaccu   2400

cucugucuuu uuccuuccug agaaacgucc aucucucucc cuuacuauuc ccacuuucau   2460

ucaaucaacc ugcacuucau aucuagauuu cuagaaaagc uuccuagcuu aucucccugc   2520

uucauaucuc ucccuucuuu accuucauuu cauccuguug gcugcugcca ccaaaucugu   2580

cuagaauccu gcuuuacagg aucauguaaa ugcucaaaga uguaauguag uucuuuguuc   2640

cugcuuucuc uuucaguauu aaacucuccu uugauauuau guggcuuuua uuucagugcc   2700

auacauguua uuguuuucaa ccuagaaacc uuuaucccug cuuaucugaa acuucccaac   2760

uucccuguuc uuuaagacuu uuuuuuuuuu uuuuuuuuuu uuugagacag agucucgcuc   2820

ugucgcccag gcuggagggc aguggcacga ucucagcuca cugcaagcuc caacucccgg   2880

guucacgcca uucuccugcc ucagccuucc aaguagcugg gacuacaggu gcccgccacc   2940

gugcccggcu aauuuuuuug uauuuuuagu agagacaggg uuucaccaug uuagccggga   3000

uggucuugau cuccugaccu caugauccac ccaccucagc cucccaaagu guugggauua   3060

caggcgugag ccacugcgcc cgggcaagac cuuuuuuuaa aaaaaaaaaa aaaaaaacuu   3120

ccauucuuuc uuccuccagu cuguucucac auaacagagu aguuuugguu uuuaauuuuu   3180

uuugguuguu ugcuguuuuu uguuuuuuaa ggugaguucu cacuauguuu cucagacugg   3240

ucucgaacuc cuggccucaa gccaucuucc cgccucagcc ucucaaauag cugggcuuac   3300

aggcaugagc caccacaccu ggccaggauu ugguuguuua aauauaaauc ugaucacccc   3360

ccugcuuaga acccuucugc uuucuauuac cccucauuua aaauguaaac ucuucaccuu   3420

gguuuaugag aacugguucu ugccuucccc uugaaccuca uuaaauggug auuucuugcu   3480

aagcuccagc ccgagugguc uccucucagc uucuaauuuu gugcucuuuc cugcccuuuu   3540

ccugggccuu cucagcucuc cacccccacc acucuugacu cagguggugu ccuucuuccu   3600

caagucuuga caauucccgg gcccuucagu cccugagcag ucuacuucug ugucugucac   3660

cacaucuugu cuuuuccccu cauugcauuu auugcaguuu auauauaugc uacuuuuacu   3720

uguucauuuc ugucuccccu accaggcugu aaaugagggc agaaaccuug uuuguuuuau   3780

ucaccaucau guaccaagug cuuggcacau agugggccuu cauuaaaugu uuguugaaua   3840

aaagagggaa gaaggcaagc caaccuuagc uacaauccua ccuuuugaua aaauguuccu   3900

uuugacaaua uacacggauu auuauuugua cuuuguuuuu ccauguguuu ugcuuuuauc   3960

cacuggcauu uuuagcuccu ugaagacaua ucauguguga gauaacuucc uucacaucuc   4020

ccaugguccc uagcaaaaug cuaggccugu aguagucaag gugcucaaua aauauuuguu   4080

ugggugguuu gugagccuug cugccaaguc cugccuuugg gucgacauag uauggaagua   4140

uuugagagag agaaccuuuc cacucccacu gccaggauuu uguauugcca ucgggugcca   4200

aauaaaugcu cauauuuauu acugaaaaaa aaaaaaaaaa aa                      4242


<210>  4
<211>  4057
<212>  RNA
<213>  Homo_sapiens

<300>
<308>  NM_001224.4   
<309>  2012-12-23
<313>  (1)..(4057)

<400>  4
agaggaagag aacgauuuaa ggagcgaaua cuacugguaa acuaauggaa gaaaucugcu     60

gcaccacugg auauugggag uguguggcau gcauccucau caucaggaaa cucuaaaaaa    120

gaaccgagug gugcuagcca aacagcuguu guugagcgaa uuguuagaac aucuucugga    180

gaaggacauc aucaccuugg aaaugaggga gcucauccag gccaaagugg gcaguuucag    240

ccagaaugug gaacuccuca acuugcugcc uaagaggggu ccccaagcuu uugaugccuu    300

cugugaagca cugagggaga ccaagcaagg ccaccuggag gauauguugc ucaccacccu    360

uucugggcuu cagcauguac ucccaccguu gagcugugac uacgacuuga gucucccuuu    420

uccggugugu gaguccuguc cccuuuacaa gaagcuccgc cugucgacag auacugugga    480

acacucccua gacaauaaag augguccugu cugccuucag gugaagccuu gcacuccuga    540

auuuuaucaa acacacuucc agcuggcaua uagguugcag ucucggccuc guggccuagc    600

acugguguug agcaaugugc acuucacugg agagaaagaa cuggaauuuc gcucuggagg    660

ggauguggac cacaguacuc uagucacccu cuucaagcuu uugggcuaug acguccaugu    720

ucuaugugac cagacugcac aggaaaugca agagaaacug cagaauuuug cacaguuacc    780

ugcacaccga gucacggacu ccugcaucgu ggcacuccuc ucgcauggug uggagggcgc    840

caucuauggu guggauggga aacugcucca gcuccaagag guuuuucagc ucuuugacaa    900

cgccaacugc ccaagccuac agaacaaacc aaaaauguuc uucauccagg ccugccgugg    960

aggugcuauu ggaucccuug ggcaccuccu ucuguucacu gcugccaccg ccucucuugc   1020

ucuaugagac ugaucguggg guugaccaac aagauggaaa gaaccacgca ggauccccug   1080

ggugcgagga gagugaugcc gguaaagaaa aguugccgaa gaugagacug cccacgcgcu   1140

cagacaugau augcggcuau gccugccuca aagggacugc cgccaugcgg aacaccaaac   1200

gagguuccug guacaucgag gcucuugcuc aaguguuuuc ugagcgggcu ugugauaugc   1260

acguggccga caugcugguu aaggugaacg cacuuaucaa ggaucgggaa gguuaugcuc   1320

cuggcacaga auuccaccgg ugcaaggaga ugucugaaua cugcagcacu cugugccgcc   1380

accucuaccu guucccagga cacccuccca caugauguca ccuccccauc auccacgcca   1440

aguggaagcc acuggaccac aggaggugug auagagccuu ugaucuucag gaugcacggu   1500

uucuguucug cccccucagg gaugugggaa ucucccagac uuguuuccug ugcccaucau   1560

cucugccuuu gaguguggga cuccaggcca gcuccuuuuc ugugaagccc uuugccugua   1620

gagccagccu ugguuggacc uauugccagg aauguuucag cugcaguuga agagccugac   1680

aagugaaguu guaaacacag ugugguuaug gggagagggc auauaaauuc cccauauuug   1740

uguucaguuc cagcuuuugu agauggcacu uuagugauug cuuuuauuac auuaguuaag   1800

augucugaga gaccaucucc uaucuuuuau uucauucaua uccuccgccc uuuuuguccu   1860

agagugagag uuuggaaggu guccaaauuu aauguagaca uuaucuuuug gcucugaaga   1920

agcaaacaug acuagagacg caccuugcug caguguccag aagcggccug ugcguucccu   1980

ucaguacugc agcgccaccc aguggaagga cacucuuggc ucguuugggc ucaaggcacc   2040

gcagccuguc agccaacauu gccuugcauu uguaccuuau ugaucuuugc ccauggaagu   2100

cucaaagauc uuucguuggu uguuucucug agcuuuguua cugaaaugag ccucgugggg   2160

agcaucagag aaggccagga agaauggugu guuucccuag acucuguaac caccucucug   2220

ucuuuuuccu uccugagaaa cguccaucuc ucucccuuac uauucccacu uucauucaau   2280

caaccugcac uucauaucua gauuucuaga aaagcuuccu agcuuaucuc ccugcuucau   2340

aucucucccu ucuuuaccuu cauuucaucc uguuggcugc ugccaccaaa ucugucuaga   2400

auccugcuuu acaggaucau guaaaugcuc aaagauguaa uguaguucuu uguuccugcu   2460

uucucuuuca guauuaaacu cuccuuugau auuauguggc uuuuauuuca gugccauaca   2520

uguuauuguu uucaaccuag aaaccuuuau cccugcuuau cugaaacuuc ccaacuuccc   2580

uguucuuuaa gacuuuuuuu uuuuuuuuuu uuuuuuuuga gacagagucu cgcucugucg   2640

cccaggcugg agggcagugg cacgaucuca gcucacugca agcuccaacu cccggguuca   2700

cgccauucuc cugccucagc cuuccaagua gcugggacua caggugcccg ccaccgugcc   2760

cggcuaauuu uuuuguauuu uuaguagaga caggguuuca ccauguuagc cgggaugguc   2820

uugaucuccu gaccucauga uccacccacc ucagccuccc aaaguguugg gauuacaggc   2880

gugagccacu gcgcccgggc aagaccuuuu uuuaaaaaaa aaaaaaaaaa aacuuccauu   2940

cuuucuuccu ccagucuguu cucacauaac agaguaguuu ugguuuuuaa uuuuuuuugg   3000

uuguuugcug uuuuuuguuu uuuaagguga guucucacua uguuucucag acuggucucg   3060

aacuccuggc cucaagccau cuucccgccu cagccucuca aauagcuggg cuuacaggca   3120

ugagccacca caccuggcca ggauuugguu guuuaaauau aaaucugauc accccccugc   3180

uuagaacccu ucugcuuucu auuaccccuc auuuaaaaug uaaacucuuc accuugguuu   3240

augagaacug guucuugccu uccccuugaa ccucauuaaa uggugauuuc uugcuaagcu   3300

ccagcccgag uggucuccuc ucagcuucua auuuugugcu cuuuccugcc cuuuuccugg   3360

gccuucucag cucuccaccc ccaccacucu ugacucaggu gguguccuuc uuccucaagu   3420

cuugacaauu cccgggcccu ucagucccug agcagucuac uucugugucu gucaccacau   3480

cuugucuuuu ccccucauug cauuuauugc aguuuauaua uaugcuacuu uuacuuguuc   3540

auuucugucu ccccuaccag gcuguaaaug agggcagaaa ccuuguuugu uuuauucacc   3600

aucauguacc aagugcuugg cacauagugg gccuucauua aauguuuguu gaauaaaaga   3660

gggaagaagg caagccaacc uuagcuacaa uccuaccuuu ugauaaaaug uuccuuuuga   3720

caauauacac ggauuauuau uuguacuuug uuuuuccaug uguuuugcuu uuauccacug   3780

gcauuuuuag cuccuugaag acauaucaug ugugagauaa cuuccuucac aucucccaug   3840

gucccuagca aaaugcuagg ccuguaguag ucaaggugcu caauaaauau uuguuugggu   3900

gguuugugag ccuugcugcc aaguccugcc uuugggucga cauaguaugg aaguauuuga   3960

gagagagaac cuuuccacuc ccacugccag gauuuuguau ugccaucggg ugccaaauaa   4020

augcucauau uuauuacuga aaaaaaaaaa aaaaaaa                            4057


<210>  5
<211>  4024
<212>  RNA
<213>  Homo_sapiens

<300>
<308>  NM_032983.3 
<309>  2012-12-23
<313>  (1)..(4024)

<400>  5
cuuuugucug uccgccgagc accccacuuc accccauugg accgcgcggc cgccgcuaga     60

gcucugcgcc ugcgcacgca ccgggccggg gacugggugg ccuggugugu gggcgcggca    120

gggcgcaggc gcaggcgcag ugugcguccg cgucugaggg gagggaugug ggggaagcga    180

cggcccccgg uuuguuuggg cugugggcgg ugcgcagcgg agagcccggg aaaagcggga    240

aauggcggcg ccgagcgcgg ggucuugguc caccuuccag cacaaggagc ugauggccgc    300

ugacagggga cgcaggauau ugggagugug uggcaugcau ccucaucauc aggaaacucu    360

aaaaaagaac cgaguggugc uagccaaaca gcuguuguug agcgaauugu uagaacaucu    420

ucuggagaag gacaucauca ccuuggaaau gagggagcuc auccaggcca aagugggcag    480

uuucagccag aauguggaac uccucaacuu gcugccuaag aggggucccc aagcuuuuga    540

ugccuucugu gaagccuugc acuccugaau uuuaucaaac acacuuccag cuggcauaua    600

gguugcaguc ucggccucgu ggccuagcac ugguguugag caaugugcac uucacuggag    660

agaaagaacu ggaauuucgc ucuggagggg auguggacca caguacucua gucacccucu    720

ucaagcuuuu gggcuaugac guccauguuc uaugugacca gacugcacag gaaaugcaag    780

agaaacugca gaauuuugca caguuaccug cacaccgagu cacggacucc ugcaucgugg    840

cacuccucuc gcauggugug gagggcgcca ucuauggugu ggaugggaaa cugcuccagc    900

uccaagaggu uuuucagcuc uuugacaacg ccaacugccc aagccuacag aacaaaccaa    960

aaauguucuu cauccaggcc ugccguggag augagacuga ucgugggguu gaccaacaag   1020

auggaaagaa ccacgcagga uccccugggu gcgaggagag ugaugccggu aaagaaaagu   1080

ugccgaagau gagacugccc acgcgcucag acaugauaug cggcuaugcc ugccucaaag   1140

ggacugccgc caugcggaac accaaacgag guuccuggua caucgaggcu cuugcucaag   1200

uguuuucuga gcgggcuugu gauaugcacg uggccgacau gcugguuaag gugaacgcac   1260

uuaucaagga ucgggaaggu uaugcuccug gcacagaauu ccaccggugc aaggagaugu   1320

cugaauacug cagcacucug ugccgccacc ucuaccuguu cccaggacac ccucccacau   1380

gaugucaccu ccccaucauc cacgccaagu ggaagccacu ggaccacagg aggugugaua   1440

gagccuuuga ucuucaggau gcacgguuuc uguucugccc ccucagggau gugggaaucu   1500

cccagacuug uuuccugugc ccaucaucuc ugccuuugag ugugggacuc caggccagcu   1560

ccuuuucugu gaagcccuuu gccuguagag ccagccuugg uuggaccuau ugccaggaau   1620

guuucagcug caguugaaga gccugacaag ugaaguugua aacacagugu gguuaugggg   1680

agagggcaua uaaauucccc auauuugugu ucaguuccag cuuuuguaga uggcacuuua   1740

gugauugcuu uuauuacauu aguuaagaug ucugagagac caucuccuau cuuuuauuuc   1800

auucauaucc uccgcccuuu uuguccuaga gugagaguuu ggaagguguc caaauuuaau   1860

guagacauua ucuuuuggcu cugaagaagc aaacaugacu agagacgcac cuugcugcag   1920

uguccagaag cggccugugc guucccuuca guacugcagc gccacccagu ggaaggacac   1980

ucuuggcucg uuugggcuca aggcaccgca gccugucagc caacauugcc uugcauuugu   2040

accuuauuga ucuuugccca uggaagucuc aaagaucuuu cguugguugu uucucugagc   2100

uuuguuacug aaaugagccu cguggggagc aucagagaag gccaggaaga augguguguu   2160

ucccuagacu cuguaaccac cucucugucu uuuuccuucc ugagaaacgu ccaucucucu   2220

cccuuacuau ucccacuuuc auucaaucaa ccugcacuuc auaucuagau uucuagaaaa   2280

gcuuccuagc uuaucucccu gcuucauauc ucucccuucu uuaccuucau uucauccugu   2340

uggcugcugc caccaaaucu gucuagaauc cugcuuuaca ggaucaugua aaugcucaaa   2400

gauguaaugu aguucuuugu uccugcuuuc ucuuucagua uuaaacucuc cuuugauauu   2460

auguggcuuu uauuucagug ccauacaugu uauuguuuuc aaccuagaaa ccuuuauccc   2520

ugcuuaucug aaacuuccca acuucccugu ucuuuaagac uuuuuuuuuu uuuuuuuuuu   2580

uuuuugagac agagucucgc ucugucgccc aggcuggagg gcaguggcac gaucucagcu   2640

cacugcaagc uccaacuccc ggguucacgc cauucuccug ccucagccuu ccaaguagcu   2700

gggacuacag gugcccgcca ccgugcccgg cuaauuuuuu uguauuuuua guagagacag   2760

gguuucacca uguuagccgg gauggucuug aucuccugac cucaugaucc acccaccuca   2820

gccucccaaa guguugggau uacaggcgug agccacugcg cccgggcaag accuuuuuuu   2880

aaaaaaaaaa aaaaaaaaac uuccauucuu ucuuccucca gucuguucuc acauaacaga   2940

guaguuuugg uuuuuaauuu uuuuugguug uuugcuguuu uuuguuuuuu aaggugaguu   3000

cucacuaugu uucucagacu ggucucgaac uccuggccuc aagccaucuu cccgccucag   3060

ccucucaaau agcugggcuu acaggcauga gccaccacac cuggccagga uuugguuguu   3120

uaaauauaaa ucugaucacc ccccugcuua gaacccuucu gcuuucuauu accccucauu   3180

uaaaauguaa acucuucacc uugguuuaug agaacugguu cuugccuucc ccuugaaccu   3240

cauuaaaugg ugauuucuug cuaagcucca gcccgagugg ucuccucuca gcuucuaauu   3300

uugugcucuu uccugcccuu uuccugggcc uucucagcuc uccaccccca ccacucuuga   3360

cucagguggu guccuucuuc cucaagucuu gacaauuccc gggcccuuca gucccugagc   3420

agucuacuuc ugugucuguc accacaucuu gucuuuuccc cucauugcau uuauugcagu   3480

uuauauauau gcuacuuuua cuuguucauu ucugucuccc cuaccaggcu guaaaugagg   3540

gcagaaaccu uguuuguuuu auucaccauc auguaccaag ugcuuggcac auagugggcc   3600

uucauuaaau guuuguugaa uaaaagaggg aagaaggcaa gccaaccuua gcuacaaucc   3660

uaccuuuuga uaaaauguuc cuuuugacaa uauacacgga uuauuauuug uacuuuguuu   3720

uuccaugugu uuugcuuuua uccacuggca uuuuuagcuc cuugaagaca uaucaugugu   3780

gagauaacuu ccuucacauc ucccaugguc ccuagcaaaa ugcuaggccu guaguaguca   3840

aggugcucaa uaaauauuug uuuggguggu uugugagccu ugcugccaag uccugccuuu   3900

gggucgacau aguauggaag uauuugagag agagaaccuu uccacuccca cugccaggau   3960

uuuguauugc caucgggugc caaauaaaug cucauauuua uuacugaaaa aaaaaaaaaa   4020

aaaa                                                                4024


<210>  6
<211>  452
<212>  PRT
<213>  Homo_sapiens

<300>
<308>  NP_116764.2 
<309>  2012-12-23
<313>  (1)..(452)

<400>  6

Met Ala Ala Pro Ser Ala Gly Ser Trp Ser Thr Phe Gln His Lys Glu 
1               5                   10                  15      


Leu Met Ala Ala Asp Arg Gly Arg Arg Ile Leu Gly Val Cys Gly Met 
            20                  25                  30          


His Pro His His Gln Glu Thr Leu Lys Lys Asn Arg Val Val Leu Ala 
        35                  40                  45              


Lys Gln Leu Leu Leu Ser Glu Leu Leu Glu His Leu Leu Glu Lys Asp 
    50                  55                  60                  


Ile Ile Thr Leu Glu Met Arg Glu Leu Ile Gln Ala Lys Val Gly Ser 
65                  70                  75                  80  


Phe Ser Gln Asn Val Glu Leu Leu Asn Leu Leu Pro Lys Arg Gly Pro 
                85                  90                  95      


Gln Ala Phe Asp Ala Phe Cys Glu Ala Leu Arg Glu Thr Lys Gln Gly 
            100                 105                 110         


His Leu Glu Asp Met Leu Leu Thr Thr Leu Ser Gly Leu Gln His Val 
        115                 120                 125             


Leu Pro Pro Leu Ser Cys Asp Tyr Asp Leu Ser Leu Pro Phe Pro Val 
    130                 135                 140                 


Cys Glu Ser Cys Pro Leu Tyr Lys Lys Leu Arg Leu Ser Thr Asp Thr 
145                 150                 155                 160 


Val Glu His Ser Leu Asp Asn Lys Asp Gly Pro Val Cys Leu Gln Val 
                165                 170                 175     


Lys Pro Cys Thr Pro Glu Phe Tyr Gln Thr His Phe Gln Leu Ala Tyr 
            180                 185                 190         


Arg Leu Gln Ser Arg Pro Arg Gly Leu Ala Leu Val Leu Ser Asn Val 
        195                 200                 205             


His Phe Thr Gly Glu Lys Glu Leu Glu Phe Arg Ser Gly Gly Asp Val 
    210                 215                 220                 


Asp His Ser Thr Leu Val Thr Leu Phe Lys Leu Leu Gly Tyr Asp Val 
225                 230                 235                 240 


His Val Leu Cys Asp Gln Thr Ala Gln Glu Met Gln Glu Lys Leu Gln 
                245                 250                 255     


Asn Phe Ala Gln Leu Pro Ala His Arg Val Thr Asp Ser Cys Ile Val 
            260                 265                 270         


Ala Leu Leu Ser His Gly Val Glu Gly Ala Ile Tyr Gly Val Asp Gly 
        275                 280                 285             


Lys Leu Leu Gln Leu Gln Glu Val Phe Gln Leu Phe Asp Asn Ala Asn 
    290                 295                 300                 


Cys Pro Ser Leu Gln Asn Lys Pro Lys Met Phe Phe Ile Gln Ala Cys 
305                 310                 315                 320 


Arg Gly Asp Glu Thr Asp Arg Gly Val Asp Gln Gln Asp Gly Lys Asn 
                325                 330                 335     


His Ala Gly Ser Pro Gly Cys Glu Glu Ser Asp Ala Gly Lys Glu Lys 
            340                 345                 350         


Leu Pro Lys Met Arg Leu Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr 
        355                 360                 365             


Ala Cys Leu Lys Gly Thr Ala Ala Met Arg Asn Thr Lys Arg Gly Ser 
    370                 375                 380                 


Trp Tyr Ile Glu Ala Leu Ala Gln Val Phe Ser Glu Arg Ala Cys Asp 
385                 390                 395                 400 


Met His Val Ala Asp Met Leu Val Lys Val Asn Ala Leu Ile Lys Asp 
                405                 410                 415     


Arg Glu Gly Tyr Ala Pro Gly Thr Glu Phe His Arg Cys Lys Glu Met 
            420                 425                 430         


Ser Glu Tyr Cys Ser Thr Leu Cys Arg His Leu Tyr Leu Phe Pro Gly 
        435                 440                 445             


His Pro Pro Thr 
    450         


<210>  7
<211>  312
<212>  PRT
<213>  Homo_sapiens

<300>
<308>  NP_001215.1
<309>  2012-12-23
<313>  (1)..(312)

<400>  7

Met His Pro His His Gln Glu Thr Leu Lys Lys Asn Arg Val Val Leu 
1               5                   10                  15      


Ala Lys Gln Leu Leu Leu Ser Glu Leu Leu Glu His Leu Leu Glu Lys 
            20                  25                  30          


Asp Ile Ile Thr Leu Glu Met Arg Glu Leu Ile Gln Ala Lys Val Gly 
        35                  40                  45              


Ser Phe Ser Gln Asn Val Glu Leu Leu Asn Leu Leu Pro Lys Arg Gly 
    50                  55                  60                  


Pro Gln Ala Phe Asp Ala Phe Cys Glu Ala Leu Arg Glu Thr Lys Gln 
65                  70                  75                  80  


Gly His Leu Glu Asp Met Leu Leu Thr Thr Leu Ser Gly Leu Gln His 
                85                  90                  95      


Val Leu Pro Pro Leu Ser Cys Asp Tyr Asp Leu Ser Leu Pro Phe Pro 
            100                 105                 110         


Val Cys Glu Ser Cys Pro Leu Tyr Lys Lys Leu Arg Leu Ser Thr Asp 
        115                 120                 125             


Thr Val Glu His Ser Leu Asp Asn Lys Asp Gly Pro Val Cys Leu Gln 
    130                 135                 140                 


Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln Thr His Phe Gln Leu Ala 
145                 150                 155                 160 


Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu Ala Leu Val Leu Ser Asn 
                165                 170                 175     


Val His Phe Thr Gly Glu Lys Glu Leu Glu Phe Arg Ser Gly Gly Asp 
            180                 185                 190         


Val Asp His Ser Thr Leu Val Thr Leu Phe Lys Leu Leu Gly Tyr Asp 
        195                 200                 205             


Val His Val Leu Cys Asp Gln Thr Ala Gln Glu Met Gln Glu Lys Leu 
    210                 215                 220                 


Gln Asn Phe Ala Gln Leu Pro Ala His Arg Val Thr Asp Ser Cys Ile 
225                 230                 235                 240 


Val Ala Leu Leu Ser His Gly Val Glu Gly Ala Ile Tyr Gly Val Asp 
                245                 250                 255     


Gly Lys Leu Leu Gln Leu Gln Glu Val Phe Gln Leu Phe Asp Asn Ala 
            260                 265                 270         


Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys Met Phe Phe Ile Gln Ala 
        275                 280                 285             


Cys Arg Gly Gly Ala Ile Gly Ser Leu Gly His Leu Leu Leu Phe Thr 
    290                 295                 300                 


Ala Ala Thr Ala Ser Leu Ala Leu 
305                 310         


<210>  8
<211>  108
<212>  PRT
<213>  Homo_sapiens

<300>
<308>  NP_116765.2 
<309>  2012-12-23
<313>  (1)..(108)

<400>  8

Met Ala Ala Pro Ser Ala Gly Ser Trp Ser Thr Phe Gln His Lys Glu 
1               5                   10                  15      


Leu Met Ala Ala Asp Arg Gly Arg Arg Ile Leu Gly Val Cys Gly Met 
            20                  25                  30          


His Pro His His Gln Glu Thr Leu Lys Lys Asn Arg Val Val Leu Ala 
        35                  40                  45              


Lys Gln Leu Leu Leu Ser Glu Leu Leu Glu His Leu Leu Glu Lys Asp 
    50                  55                  60                  


Ile Ile Thr Leu Glu Met Arg Glu Leu Ile Gln Ala Lys Val Gly Ser 
65                  70                  75                  80  


Phe Ser Gln Asn Val Glu Leu Leu Asn Leu Leu Pro Lys Arg Gly Pro 
                85                  90                  95      


Gln Ala Phe Asp Ala Phe Cys Glu Ala Leu His Ser 
            100                 105             


