
                                SEQUENCE LISTING

<110> University of South Alabama
      Reed, Eddie
      Samant, Lalita
      Samant, Rajeev

<120> METHODS AND COMPOSITIONS FOR THE
  TREATMENT OF CANCER

<130> USA.012WO

<150> 61/584049           
<151> 2012-01-06  

<160> 50

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 1
cctcgtagct ttcatcaac                                              19

<210> 2
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 2
tcatcaactc gcgatgcac                                              19

<210> 3
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 3
ccaaacgcta tacagatcc                                              19

<210> 4
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 4
ccctcgtagc tttcatcaa                                              19

<210> 5
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 5
cgtagctttc atcaactcg                                              19

<210> 6
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 6
gtagctttca tcaactcgc                                              19

<210> 7
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 7
tagctttcat caactcgcg                                              19

<210> 8
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 8
ttcatcaact cgcgatgca                                              19

<210> 9
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 9
catcaactcg cgatgcaca                                              19

<210> 10
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 10
atcaactcgc gatgcacat                                              19

<210> 11
<211> 3618
<212> DNA
<213> Homo Sapiens

<220> 
<221> gene           
<222> (1)...(3618)
<223> GLI1 gene

<400> 11
cccagactcc agccctggac cgcgcatccc gagcccagcg cccagacaga gtgtccccac 60
accctcctct gagacgccat gttcaactcg atgaccccac caccaatcag tagctatggc 120
gagccctgct gtctccggcc cctccccagt cagggggccc ccagtgtggg gacagaagga 180
ctgtctggcc cgcccttctg ccaccaagct aacctcatgt ccggccccca cagttatggg 240
ccagccagag agaccaacag ctgcaccgag ggcccactct tttcttctcc ccggagtgca 300
gtcaagttga ccaagaagcg ggcactgtcc atctcacctc tgtcggatgc cagcctggac 360
ctgcagacgg ttatccgcac ctcacccagc tccctcgtag ctttcatcaa ctcgcgatgc 420
acatctccag gaggctccta cggtcatctc tccattggca ccatgagccc atctctggga 480
ttcccagccc agatgaatca ccaaaaaggg ccctcgcctt cctttggggt ccagccttgt 540
ggtccccatg actctgcccg gggtgggatg atcccacatc ctcagtcccg gggacccttc 600
ccaacttgcc agctgaagtc tgagctggac atgctggttg gcaagtgccg ggaggaaccc 660
ttggaaggtg atatgtccag ccccaactcc acaggcatac aggatcccct gttggggatg 720
ctggatgggc gggaggacct cgagagagag gagaagcgtg agcctgaatc tgtgtatgaa 780
actgactgcc gttgggatgg ctgcagccag gaatttgact cccaagagca gctggtgcac 840
cacatcaaca gcgagcacat ccacggggag cggaaggagt tcgtgtgcca ctgggggggc 900
tgctccaggg agctgaggcc cttcaaagcc cagtacatgc tggtggttca catgcgcaga 960
cacactggcg agaagccaca caagtgcacg tttgaagggt gccggaagtc atactcacgc 1020
ctcgaaaacc tgaagacgca cctgcggtca cacacgggtg agaagccata catgtgtgag 1080
cacgagggct gcagtaaagc cttcagcaat gccagtgacc gagccaagca ccagaatcgg 1140
acccattcca atgagaagcc gtatgtatgt aagctccctg gctgcaccaa acgctataca 1200
gatcctagct cgctgcgaaa acatgtcaag acagtgcatg gtcctgacgc ccatgtgacc 1260
aaacggcacc gtggggatgg ccccctgcct cgggcaccat ccatttctac agtggagccc 1320
aagagggagc gggaaggagg tcccatcagg gaggaaagca gactgactgt gccagagggt 1380
gccatgaagc cacagccaag ccctggggcc cagtcatcct gcagcagtga ccactccccg 1440
gcagggagtg cagccaatac agacagtggt gtggaaatga ctggcaatgc agggggcagc 1500
actgaagacc tctccagctt ggacgaggga ccttgcattg ctggcactgg tctgtccact 1560
cttcgccgcc ttgagaacct caggctggac cagctacatc aactccggcc aatagggacc 1620
cggggtctca aactgcccag cttgtcccac accggtacca ctgtgtcccg ccgcgtgggc 1680
cccccagtct ctcttgaacg ccgcagcagc agctccagca gcatcagctc tgcctatact 1740
gtcagccgcc gctcctccct ggcctctcct ttcccccctg gctccccacc agagaatgga 1800
gcatcctccc tgcctggcct tatgcctgcc cagcactacc tgcttcgggc aagatatgct 1860
tcagccagag ggggtggtac ttcgcccact gcagcatcca gcctggatcg gataggtggt 1920
cttcccatgc ctccttggag aagccgagcc gagtatccag gatacaaccc caatgcaggg 1980
gtcacccgga gggccagtga cccagcccag gctgctgacc gtcctgctcc agctagagtc 2040
cagaggttca agagcctggg ctgtgtccat accccaccca ctgtggcagg gggaggacag 2100
aactttgatc cttacctccc aacctctgtc tactcaccac agccccccag catcactgag 2160
aatgctgcca tggatgctag agggctacag gaagagccag aagttgggac ctccatggtg 2220
ggcagtggtc tgaaccccta tatggacttc ccacctactg atactctggg atatggggga 2280
cctgaagggg cagcagctga gccttatgga gcgaggggtc caggctctct gcctcttggg 2340
cctggtccac ccaccaacta tggccccaac ccctgtcccc agcaggcctc atatcctgac 2400
cccacccaag aaacatgggg tgagttccct tcccactctg ggctgtaccc aggccccaag 2460
gctctaggtg gaacctacag ccagtgtcct cgacttgaac attatggaca agtgcaagtc 2520
aagccagaac aggggtgccc agtggggtct gactccacag gactggcacc ctgcctcaat 2580
gcccacccca gtgaggggcc cccacatcca cagcctctct tttcccatta cccccagccc 2640
tctcctcccc aatatctcca gtcaggcccc tatacccagc caccccctga ttatcttcct 2700
tcagaaccca ggccttgcct ggactttgat tcccccaccc attccacagg gcagctcaag 2760
gctcagcttg tgtgtaatta tgttcaatct caacaggagc tactgtggga gggtgggggc 2820
agggaagatg cccccgccca ggaaccttcc taccagagtc ccaagtttct ggggggttcc 2880
caggttagcc caagccgtgc taaagctcca gtgaacacat atggacctgg ctttggaccc 2940
aacttgccca atcacaagtc aggttcctat cccacccctt caccatgcca tgaaaatttt 3000
gtagtggggg caaatagggc ttcacatagg gcagcagcac cacctcgact tctgccccca 3060
ttgcccactt gctatgggcc tctcaaagtg ggaggcacaa accccagctg tggtcatcct 3120
gaggtgggca ggctaggagg gggtcctgcc ttgtaccctc ctcccgaagg acaggtatgt 3180
aaccccctgg actctcttga tcttgacaac actcagctgg actttgtggc tattctggat 3240
gagccccagg ggctgagtcc tcctccttcc catgatcagc ggggcagctc tggacatacc 3300
ccacctccct ctgggccccc caacatggct gtgggcaaca tgagtgtctt actgagatcc 3360
ctacctgggg aaacagaatt cctcaactct agtgcctaaa gagtagggaa tctcatccat 3420
cacagatcgc atttcctaag gggtttctat ccttccagaa aaattggggg agctgcagtc 3480
ccatgcacaa gatgccccag ggatgggagg tatgggctgg gggctatgta tagtctgtat 3540
acgttttgag gagaaatttg ataatgacac tgtttcctga taataaagga actgcatcag 3600
aaaaaaaaaa aaaaaaaa                                               3618

<210> 12
<211> 17
<212> DNA
<213> Homo Sapiens

<220> 
<221> misc_binding   
<222> (1)...(17)
<223> GLI1-binding site

<400> 12
tgctgaatgc ccatccc                                                17

<210> 13
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 13
ctcagcggcc gctaataaat gaaaaagc                                    28

<210> 14
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 14
gttagcggcc gctgagagtt ccaggaag                                    28

<210> 15
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 15
gtttttccct actttctccc                                             20

<210> 16
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 16
ccaaaaacgc acacacac                                               18

<210> 17
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 17
ttccccctac caaatgttca                                             20

<210> 18
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 18
tgctgcaaaa gtaattgtgg tt                                          22

<210> 19
<211> 1106
<212> PRT
<213> Homo Sapiens

<400> 19
Met Phe Asn Ser Met Thr Pro Pro Pro Ile Ser Ser Tyr Gly Glu Pro
 1               5                  10                  15      
Cys Cys Leu Arg Pro Leu Pro Ser Gln Gly Ala Pro Ser Val Gly Thr
            20                  25                  30          
Glu Gly Leu Ser Gly Pro Pro Phe Cys His Gln Ala Asn Leu Met Ser
        35                  40                  45              
Gly Pro His Ser Tyr Gly Pro Ala Arg Glu Thr Asn Ser Cys Thr Glu
    50                  55                  60                  
Gly Pro Leu Phe Ser Ser Pro Arg Ser Ala Val Lys Leu Thr Lys Lys
65                  70                  75                  80  
Arg Ala Leu Ser Ile Ser Pro Leu Ser Asp Ala Ser Leu Asp Leu Gln
                85                  90                  95      
Thr Val Ile Arg Thr Ser Pro Ser Ser Leu Val Ala Phe Ile Asn Ser
            100                 105                 110         
Arg Cys Thr Ser Pro Gly Gly Ser Tyr Gly His Leu Ser Ile Gly Thr
        115                 120                 125             
Met Ser Pro Ser Leu Gly Phe Pro Ala Gln Met Asn His Gln Lys Gly
    130                 135                 140                 
Pro Ser Pro Ser Phe Gly Val Gln Pro Cys Gly Pro His Asp Ser Ala
145                 150                 155                 160 
Arg Gly Gly Met Ile Pro His Pro Gln Ser Arg Gly Pro Phe Pro Thr
                165                 170                 175     
Cys Gln Leu Lys Ser Glu Leu Asp Met Leu Val Gly Lys Cys Arg Glu
            180                 185                 190         
Glu Pro Leu Glu Gly Asp Met Ser Ser Pro Asn Ser Thr Gly Ile Gln
        195                 200                 205             
Asp Pro Leu Leu Gly Met Leu Asp Gly Arg Glu Asp Leu Glu Arg Glu
    210                 215                 220                 
Glu Lys Arg Glu Pro Glu Ser Val Tyr Glu Thr Asp Cys Arg Trp Asp
225                 230                 235                 240 
Gly Cys Ser Gln Glu Phe Asp Ser Gln Glu Gln Leu Val His His Ile
                245                 250                 255     
Asn Ser Glu His Ile His Gly Glu Arg Lys Glu Phe Val Cys His Trp
            260                 265                 270         
Gly Gly Cys Ser Arg Glu Leu Arg Pro Phe Lys Ala Gln Tyr Met Leu
        275                 280                 285             
Val Val His Met Arg Arg His Thr Gly Glu Lys Pro His Lys Cys Thr
    290                 295                 300                 
Phe Glu Gly Cys Arg Lys Ser Tyr Ser Arg Leu Glu Asn Leu Lys Thr
305                 310                 315                 320 
His Leu Arg Ser His Thr Gly Glu Lys Pro Tyr Met Cys Glu His Glu
                325                 330                 335     
Gly Cys Ser Lys Ala Phe Ser Asn Ala Ser Asp Arg Ala Lys His Gln
            340                 345                 350         
Asn Arg Thr His Ser Asn Glu Lys Pro Tyr Val Cys Lys Leu Pro Gly
        355                 360                 365             
Cys Thr Lys Arg Tyr Thr Asp Pro Ser Ser Leu Arg Lys His Val Lys
    370                 375                 380                 
Thr Val His Gly Pro Asp Ala His Val Thr Lys Arg His Arg Gly Asp
385                 390                 395                 400 
Gly Pro Leu Pro Arg Ala Pro Ser Ile Ser Thr Val Glu Pro Lys Arg
                405                 410                 415     
Glu Arg Glu Gly Gly Pro Ile Arg Glu Glu Ser Arg Leu Thr Val Pro
            420                 425                 430         
Glu Gly Ala Met Lys Pro Gln Pro Ser Pro Gly Ala Gln Ser Ser Cys
        435                 440                 445             
Ser Ser Asp His Ser Pro Ala Gly Ser Ala Ala Asn Thr Asp Ser Gly
    450                 455                 460                 
Val Glu Met Thr Gly Asn Ala Gly Gly Ser Thr Glu Asp Leu Ser Ser
465                 470                 475                 480 
Leu Asp Glu Gly Pro Cys Ile Ala Gly Thr Gly Leu Ser Thr Leu Arg
                485                 490                 495     
Arg Leu Glu Asn Leu Arg Leu Asp Gln Leu His Gln Leu Arg Pro Ile
            500                 505                 510         
Gly Thr Arg Gly Leu Lys Leu Pro Ser Leu Ser His Thr Gly Thr Thr
        515                 520                 525             
Val Ser Arg Arg Val Gly Pro Pro Val Ser Leu Glu Arg Arg Ser Ser
    530                 535                 540                 
Ser Ser Ser Ser Ile Ser Ser Ala Tyr Thr Val Ser Arg Arg Ser Ser
545                 550                 555                 560 
Leu Ala Ser Pro Phe Pro Pro Gly Ser Pro Pro Glu Asn Gly Ala Ser
                565                 570                 575     
Ser Leu Pro Gly Leu Met Pro Ala Gln His Tyr Leu Leu Arg Ala Arg
            580                 585                 590         
Tyr Ala Ser Ala Arg Gly Gly Gly Thr Ser Pro Thr Ala Ala Ser Ser
        595                 600                 605             
Leu Asp Arg Ile Gly Gly Leu Pro Met Pro Pro Trp Arg Ser Arg Ala
    610                 615                 620                 
Glu Tyr Pro Gly Tyr Asn Pro Asn Ala Gly Val Thr Arg Arg Ala Ser
625                 630                 635                 640 
Asp Pro Ala Gln Ala Ala Asp Arg Pro Ala Pro Ala Arg Val Gln Arg
                645                 650                 655     
Phe Lys Ser Leu Gly Cys Val His Thr Pro Pro Thr Val Ala Gly Gly
            660                 665                 670         
Gly Gln Asn Phe Asp Pro Tyr Leu Pro Thr Ser Val Tyr Ser Pro Gln
        675                 680                 685             
Pro Pro Ser Ile Thr Glu Asn Ala Ala Met Asp Ala Arg Gly Leu Gln
    690                 695                 700                 
Glu Glu Pro Glu Val Gly Thr Ser Met Val Gly Ser Gly Leu Asn Pro
705                 710                 715                 720 
Tyr Met Asp Phe Pro Pro Thr Asp Thr Leu Gly Tyr Gly Gly Pro Glu
                725                 730                 735     
Gly Ala Ala Ala Glu Pro Tyr Gly Ala Arg Gly Pro Gly Ser Leu Pro
            740                 745                 750         
Leu Gly Pro Gly Pro Pro Thr Asn Tyr Gly Pro Asn Pro Cys Pro Gln
        755                 760                 765             
Gln Ala Ser Tyr Pro Asp Pro Thr Gln Glu Thr Trp Gly Glu Phe Pro
    770                 775                 780                 
Ser His Ser Gly Leu Tyr Pro Gly Pro Lys Ala Leu Gly Gly Thr Tyr
785                 790                 795                 800 
Ser Gln Cys Pro Arg Leu Glu His Tyr Gly Gln Val Gln Val Lys Pro
                805                 810                 815     
Glu Gln Gly Cys Pro Val Gly Ser Asp Ser Thr Gly Leu Ala Pro Cys
            820                 825                 830         
Leu Asn Ala His Pro Ser Glu Gly Pro Pro His Pro Gln Pro Leu Phe
        835                 840                 845             
Ser His Tyr Pro Gln Pro Ser Pro Pro Gln Tyr Leu Gln Ser Gly Pro
    850                 855                 860                 
Tyr Thr Gln Pro Pro Pro Asp Tyr Leu Pro Ser Glu Pro Arg Pro Cys
865                 870                 875                 880 
Leu Asp Phe Asp Ser Pro Thr His Ser Thr Gly Gln Leu Lys Ala Gln
                885                 890                 895     
Leu Val Cys Asn Tyr Val Gln Ser Gln Gln Glu Leu Leu Trp Glu Gly
            900                 905                 910         
Gly Gly Arg Glu Asp Ala Pro Ala Gln Glu Pro Ser Tyr Gln Ser Pro
        915                 920                 925             
Lys Phe Leu Gly Gly Ser Gln Val Ser Pro Ser Arg Ala Lys Ala Pro
    930                 935                 940                 
Val Asn Thr Tyr Gly Pro Gly Phe Gly Pro Asn Leu Pro Asn His Lys
945                 950                 955                 960 
Ser Gly Ser Tyr Pro Thr Pro Ser Pro Cys His Glu Asn Phe Val Val
                965                 970                 975     
Gly Ala Asn Arg Ala Ser His Arg Ala Ala Ala Pro Pro Arg Leu Leu
            980                 985                 990         
Pro Pro Leu Pro Thr Cys Tyr Gly Pro Leu Lys Val Gly Gly Thr Asn
        995                 1000                1005            
Pro Ser Cys Gly His Pro Glu Val Gly Arg Leu Gly Gly Gly Pro Ala
    1010                1015                1020                
Leu Tyr Pro Pro Pro Glu Gly Gln Val Cys Asn Pro Leu Asp Ser Leu
1025                1030                1035               1040 
Asp Leu Asp Asn Thr Gln Leu Asp Phe Val Ala Ile Leu Asp Glu Pro
                1045                1050                1055    
Gln Gly Leu Ser Pro Pro Pro Ser His Asp Gln Arg Gly Ser Ser Gly
            1060                1065                1070        
His Thr Pro Pro Pro Ser Gly Pro Pro Asn Met Ala Val Gly Asn Met
        1075                1080                1085            
Ser Val Leu Leu Arg Ser Leu Pro Gly Glu Thr Glu Phe Leu Asn Ser
    1090                1095                1100                
Ser Ala
1105    


<210> 20
<211> 978
<212> PRT
<213> Homo Sapiens

<400> 20
Met Ser Pro Ser Leu Gly Phe Pro Ala Gln Met Asn His Gln Lys Gly
 1               5                  10                  15      
Pro Ser Pro Ser Phe Gly Val Gln Pro Cys Gly Pro His Asp Ser Ala
            20                  25                  30          
Arg Gly Gly Met Ile Pro His Pro Gln Ser Arg Gly Pro Phe Pro Thr
        35                  40                  45              
Cys Gln Leu Lys Ser Glu Leu Asp Met Leu Val Gly Lys Cys Arg Glu
    50                  55                  60                  
Glu Pro Leu Glu Gly Asp Met Ser Ser Pro Asn Ser Thr Gly Ile Gln
65                  70                  75                  80  
Asp Pro Leu Leu Gly Met Leu Asp Gly Arg Glu Asp Leu Glu Arg Glu
                85                  90                  95      
Glu Lys Arg Glu Pro Glu Ser Val Tyr Glu Thr Asp Cys Arg Trp Asp
            100                 105                 110         
Gly Cys Ser Gln Glu Phe Asp Ser Gln Glu Gln Leu Val His His Ile
        115                 120                 125             
Asn Ser Glu His Ile His Gly Glu Arg Lys Glu Phe Val Cys His Trp
    130                 135                 140                 
Gly Gly Cys Ser Arg Glu Leu Arg Pro Phe Lys Ala Gln Tyr Met Leu
145                 150                 155                 160 
Val Val His Met Arg Arg His Thr Gly Glu Lys Pro His Lys Cys Thr
                165                 170                 175     
Phe Glu Gly Cys Arg Lys Ser Tyr Ser Arg Leu Glu Asn Leu Lys Thr
            180                 185                 190         
His Leu Arg Ser His Thr Gly Glu Lys Pro Tyr Met Cys Glu His Glu
        195                 200                 205             
Gly Cys Ser Lys Ala Phe Ser Asn Ala Ser Asp Arg Ala Lys His Gln
    210                 215                 220                 
Asn Arg Thr His Ser Asn Glu Lys Pro Tyr Val Cys Lys Leu Pro Gly
225                 230                 235                 240 
Cys Thr Lys Arg Tyr Thr Asp Pro Ser Ser Leu Arg Lys His Val Lys
                245                 250                 255     
Thr Val His Gly Pro Asp Ala His Val Thr Lys Arg His Arg Gly Asp
            260                 265                 270         
Gly Pro Leu Pro Arg Ala Pro Ser Ile Ser Thr Val Glu Pro Lys Arg
        275                 280                 285             
Glu Arg Glu Gly Gly Pro Ile Arg Glu Glu Ser Arg Leu Thr Val Pro
    290                 295                 300                 
Glu Gly Ala Met Lys Pro Gln Pro Ser Pro Gly Ala Gln Ser Ser Cys
305                 310                 315                 320 
Ser Ser Asp His Ser Pro Ala Gly Ser Ala Ala Asn Thr Asp Ser Gly
                325                 330                 335     
Val Glu Met Thr Gly Asn Ala Gly Gly Ser Thr Glu Asp Leu Ser Ser
            340                 345                 350         
Leu Asp Glu Gly Pro Cys Ile Ala Gly Thr Gly Leu Ser Thr Leu Arg
        355                 360                 365             
Arg Leu Glu Asn Leu Arg Leu Asp Gln Leu His Gln Leu Arg Pro Ile
    370                 375                 380                 
Gly Thr Arg Gly Leu Lys Leu Pro Ser Leu Ser His Thr Gly Thr Thr
385                 390                 395                 400 
Val Ser Arg Arg Val Gly Pro Pro Val Ser Leu Glu Arg Arg Ser Ser
                405                 410                 415     
Ser Ser Ser Ser Ile Ser Ser Ala Tyr Thr Val Ser Arg Arg Ser Ser
            420                 425                 430         
Leu Ala Ser Pro Phe Pro Pro Gly Ser Pro Pro Glu Asn Gly Ala Ser
        435                 440                 445             
Ser Leu Pro Gly Leu Met Pro Ala Gln His Tyr Leu Leu Arg Ala Arg
    450                 455                 460                 
Tyr Ala Ser Ala Arg Gly Gly Gly Thr Ser Pro Thr Ala Ala Ser Ser
465                 470                 475                 480 
Leu Asp Arg Ile Gly Gly Leu Pro Met Pro Pro Trp Arg Ser Arg Ala
                485                 490                 495     
Glu Tyr Pro Gly Tyr Asn Pro Asn Ala Gly Val Thr Arg Arg Ala Ser
            500                 505                 510         
Asp Pro Ala Gln Ala Ala Asp Arg Pro Ala Pro Ala Arg Val Gln Arg
        515                 520                 525             
Phe Lys Ser Leu Gly Cys Val His Thr Pro Pro Thr Val Ala Gly Gly
    530                 535                 540                 
Gly Gln Asn Phe Asp Pro Tyr Leu Pro Thr Ser Val Tyr Ser Pro Gln
545                 550                 555                 560 
Pro Pro Ser Ile Thr Glu Asn Ala Ala Met Asp Ala Arg Gly Leu Gln
                565                 570                 575     
Glu Glu Pro Glu Val Gly Thr Ser Met Val Gly Ser Gly Leu Asn Pro
            580                 585                 590         
Tyr Met Asp Phe Pro Pro Thr Asp Thr Leu Gly Tyr Gly Gly Pro Glu
        595                 600                 605             
Gly Ala Ala Ala Glu Pro Tyr Gly Ala Arg Gly Pro Gly Ser Leu Pro
    610                 615                 620                 
Leu Gly Pro Gly Pro Pro Thr Asn Tyr Gly Pro Asn Pro Cys Pro Gln
625                 630                 635                 640 
Gln Ala Ser Tyr Pro Asp Pro Thr Gln Glu Thr Trp Gly Glu Phe Pro
                645                 650                 655     
Ser His Ser Gly Leu Tyr Pro Gly Pro Lys Ala Leu Gly Gly Thr Tyr
            660                 665                 670         
Ser Gln Cys Pro Arg Leu Glu His Tyr Gly Gln Val Gln Val Lys Pro
        675                 680                 685             
Glu Gln Gly Cys Pro Val Gly Ser Asp Ser Thr Gly Leu Ala Pro Cys
    690                 695                 700                 
Leu Asn Ala His Pro Ser Glu Gly Pro Pro His Pro Gln Pro Leu Phe
705                 710                 715                 720 
Ser His Tyr Pro Gln Pro Ser Pro Pro Gln Tyr Leu Gln Ser Gly Pro
                725                 730                 735     
Tyr Thr Gln Pro Pro Pro Asp Tyr Leu Pro Ser Glu Pro Arg Pro Cys
            740                 745                 750         
Leu Asp Phe Asp Ser Pro Thr His Ser Thr Gly Gln Leu Lys Ala Gln
        755                 760                 765             
Leu Val Cys Asn Tyr Val Gln Ser Gln Gln Glu Leu Leu Trp Glu Gly
    770                 775                 780                 
Gly Gly Arg Glu Asp Ala Pro Ala Gln Glu Pro Ser Tyr Gln Ser Pro
785                 790                 795                 800 
Lys Phe Leu Gly Gly Ser Gln Val Ser Pro Ser Arg Ala Lys Ala Pro
                805                 810                 815     
Val Asn Thr Tyr Gly Pro Gly Phe Gly Pro Asn Leu Pro Asn His Lys
            820                 825                 830         
Ser Gly Ser Tyr Pro Thr Pro Ser Pro Cys His Glu Asn Phe Val Val
        835                 840                 845             
Gly Ala Asn Arg Ala Ser His Arg Ala Ala Ala Pro Pro Arg Leu Leu
    850                 855                 860                 
Pro Pro Leu Pro Thr Cys Tyr Gly Pro Leu Lys Val Gly Gly Thr Asn
865                 870                 875                 880 
Pro Ser Cys Gly His Pro Glu Val Gly Arg Leu Gly Gly Gly Pro Ala
                885                 890                 895     
Leu Tyr Pro Pro Pro Glu Gly Gln Val Cys Asn Pro Leu Asp Ser Leu
            900                 905                 910         
Asp Leu Asp Asn Thr Gln Leu Asp Phe Val Ala Ile Leu Asp Glu Pro
        915                 920                 925             
Gln Gly Leu Ser Pro Pro Pro Ser His Asp Gln Arg Gly Ser Ser Gly
    930                 935                 940                 
His Thr Pro Pro Pro Ser Gly Pro Pro Asn Met Ala Val Gly Asn Met
945                 950                 955                 960 
Ser Val Leu Leu Arg Ser Leu Pro Gly Glu Thr Glu Phe Leu Asn Ser
                965                 970                 975     
Ser Ala
        


<210> 21
<211> 1065
<212> PRT
<213> Homo Sapiens

<400> 21
Met Phe Asn Ser Met Thr Pro Pro Pro Ile Ser Ser Tyr Gly Glu Pro
 1               5                  10                  15      
Cys Cys Leu Arg Pro Leu Pro Ser Gln Gly Ala Pro Ser Val Gly Thr
            20                  25                  30          
Glu Val Lys Leu Thr Lys Lys Arg Ala Leu Ser Ile Ser Pro Leu Ser
        35                  40                  45              
Asp Ala Ser Leu Asp Leu Gln Thr Val Ile Arg Thr Ser Pro Ser Ser
    50                  55                  60                  
Leu Val Ala Phe Ile Asn Ser Arg Cys Thr Ser Pro Gly Gly Ser Tyr
65                  70                  75                  80  
Gly His Leu Ser Ile Gly Thr Met Ser Pro Ser Leu Gly Phe Pro Ala
                85                  90                  95      
Gln Met Asn His Gln Lys Gly Pro Ser Pro Ser Phe Gly Val Gln Pro
            100                 105                 110         
Cys Gly Pro His Asp Ser Ala Arg Gly Gly Met Ile Pro His Pro Gln
        115                 120                 125             
Ser Arg Gly Pro Phe Pro Thr Cys Gln Leu Lys Ser Glu Leu Asp Met
    130                 135                 140                 
Leu Val Gly Lys Cys Arg Glu Glu Pro Leu Glu Gly Asp Met Ser Ser
145                 150                 155                 160 
Pro Asn Ser Thr Gly Ile Gln Asp Pro Leu Leu Gly Met Leu Asp Gly
                165                 170                 175     
Arg Glu Asp Leu Glu Arg Glu Glu Lys Arg Glu Pro Glu Ser Val Tyr
            180                 185                 190         
Glu Thr Asp Cys Arg Trp Asp Gly Cys Ser Gln Glu Phe Asp Ser Gln
        195                 200                 205             
Glu Gln Leu Val His His Ile Asn Ser Glu His Ile His Gly Glu Arg
    210                 215                 220                 
Lys Glu Phe Val Cys His Trp Gly Gly Cys Ser Arg Glu Leu Arg Pro
225                 230                 235                 240 
Phe Lys Ala Gln Tyr Met Leu Val Val His Met Arg Arg His Thr Gly
                245                 250                 255     
Glu Lys Pro His Lys Cys Thr Phe Glu Gly Cys Arg Lys Ser Tyr Ser
            260                 265                 270         
Arg Leu Glu Asn Leu Lys Thr His Leu Arg Ser His Thr Gly Glu Lys
        275                 280                 285             
Pro Tyr Met Cys Glu His Glu Gly Cys Ser Lys Ala Phe Ser Asn Ala
    290                 295                 300                 
Ser Asp Arg Ala Lys His Gln Asn Arg Thr His Ser Asn Glu Lys Pro
305                 310                 315                 320 
Tyr Val Cys Lys Leu Pro Gly Cys Thr Lys Arg Tyr Thr Asp Pro Ser
                325                 330                 335     
Ser Leu Arg Lys His Val Lys Thr Val His Gly Pro Asp Ala His Val
            340                 345                 350         
Thr Lys Arg His Arg Gly Asp Gly Pro Leu Pro Arg Ala Pro Ser Ile
        355                 360                 365             
Ser Thr Val Glu Pro Lys Arg Glu Arg Glu Gly Gly Pro Ile Arg Glu
    370                 375                 380                 
Glu Ser Arg Leu Thr Val Pro Glu Gly Ala Met Lys Pro Gln Pro Ser
385                 390                 395                 400 
Pro Gly Ala Gln Ser Ser Cys Ser Ser Asp His Ser Pro Ala Gly Ser
                405                 410                 415     
Ala Ala Asn Thr Asp Ser Gly Val Glu Met Thr Gly Asn Ala Gly Gly
            420                 425                 430         
Ser Thr Glu Asp Leu Ser Ser Leu Asp Glu Gly Pro Cys Ile Ala Gly
        435                 440                 445             
Thr Gly Leu Ser Thr Leu Arg Arg Leu Glu Asn Leu Arg Leu Asp Gln
    450                 455                 460                 
Leu His Gln Leu Arg Pro Ile Gly Thr Arg Gly Leu Lys Leu Pro Ser
465                 470                 475                 480 
Leu Ser His Thr Gly Thr Thr Val Ser Arg Arg Val Gly Pro Pro Val
                485                 490                 495     
Ser Leu Glu Arg Arg Ser Ser Ser Ser Ser Ser Ile Ser Ser Ala Tyr
            500                 505                 510         
Thr Val Ser Arg Arg Ser Ser Leu Ala Ser Pro Phe Pro Pro Gly Ser
        515                 520                 525             
Pro Pro Glu Asn Gly Ala Ser Ser Leu Pro Gly Leu Met Pro Ala Gln
    530                 535                 540                 
His Tyr Leu Leu Arg Ala Arg Tyr Ala Ser Ala Arg Gly Gly Gly Thr
545                 550                 555                 560 
Ser Pro Thr Ala Ala Ser Ser Leu Asp Arg Ile Gly Gly Leu Pro Met
                565                 570                 575     
Pro Pro Trp Arg Ser Arg Ala Glu Tyr Pro Gly Tyr Asn Pro Asn Ala
            580                 585                 590         
Gly Val Thr Arg Arg Ala Ser Asp Pro Ala Gln Ala Ala Asp Arg Pro
        595                 600                 605             
Ala Pro Ala Arg Val Gln Arg Phe Lys Ser Leu Gly Cys Val His Thr
    610                 615                 620                 
Pro Pro Thr Val Ala Gly Gly Gly Gln Asn Phe Asp Pro Tyr Leu Pro
625                 630                 635                 640 
Thr Ser Val Tyr Ser Pro Gln Pro Pro Ser Ile Thr Glu Asn Ala Ala
                645                 650                 655     
Met Asp Ala Arg Gly Leu Gln Glu Glu Pro Glu Val Gly Thr Ser Met
            660                 665                 670         
Val Gly Ser Gly Leu Asn Pro Tyr Met Asp Phe Pro Pro Thr Asp Thr
        675                 680                 685             
Leu Gly Tyr Gly Gly Pro Glu Gly Ala Ala Ala Glu Pro Tyr Gly Ala
    690                 695                 700                 
Arg Gly Pro Gly Ser Leu Pro Leu Gly Pro Gly Pro Pro Thr Asn Tyr
705                 710                 715                 720 
Gly Pro Asn Pro Cys Pro Gln Gln Ala Ser Tyr Pro Asp Pro Thr Gln
                725                 730                 735     
Glu Thr Trp Gly Glu Phe Pro Ser His Ser Gly Leu Tyr Pro Gly Pro
            740                 745                 750         
Lys Ala Leu Gly Gly Thr Tyr Ser Gln Cys Pro Arg Leu Glu His Tyr
        755                 760                 765             
Gly Gln Val Gln Val Lys Pro Glu Gln Gly Cys Pro Val Gly Ser Asp
    770                 775                 780                 
Ser Thr Gly Leu Ala Pro Cys Leu Asn Ala His Pro Ser Glu Gly Pro
785                 790                 795                 800 
Pro His Pro Gln Pro Leu Phe Ser His Tyr Pro Gln Pro Ser Pro Pro
                805                 810                 815     
Gln Tyr Leu Gln Ser Gly Pro Tyr Thr Gln Pro Pro Pro Asp Tyr Leu
            820                 825                 830         
Pro Ser Glu Pro Arg Pro Cys Leu Asp Phe Asp Ser Pro Thr His Ser
        835                 840                 845             
Thr Gly Gln Leu Lys Ala Gln Leu Val Cys Asn Tyr Val Gln Ser Gln
    850                 855                 860                 
Gln Glu Leu Leu Trp Glu Gly Gly Gly Arg Glu Asp Ala Pro Ala Gln
865                 870                 875                 880 
Glu Pro Ser Tyr Gln Ser Pro Lys Phe Leu Gly Gly Ser Gln Val Ser
                885                 890                 895     
Pro Ser Arg Ala Lys Ala Pro Val Asn Thr Tyr Gly Pro Gly Phe Gly
            900                 905                 910         
Pro Asn Leu Pro Asn His Lys Ser Gly Ser Tyr Pro Thr Pro Ser Pro
        915                 920                 925             
Cys His Glu Asn Phe Val Val Gly Ala Asn Arg Ala Ser His Arg Ala
    930                 935                 940                 
Ala Ala Pro Pro Arg Leu Leu Pro Pro Leu Pro Thr Cys Tyr Gly Pro
945                 950                 955                 960 
Leu Lys Val Gly Gly Thr Asn Pro Ser Cys Gly His Pro Glu Val Gly
                965                 970                 975     
Arg Leu Gly Gly Gly Pro Ala Leu Tyr Pro Pro Pro Glu Gly Gln Val
            980                 985                 990         
Cys Asn Pro Leu Asp Ser Leu Asp Leu Asp Asn Thr Gln Leu Asp Phe
        995                 1000                1005            
Val Ala Ile Leu Asp Glu Pro Gln Gly Leu Ser Pro Pro Pro Ser His
    1010                1015                1020                
Asp Gln Arg Gly Ser Ser Gly His Thr Pro Pro Pro Ser Gly Pro Pro
1025                1030                1035               1040 
Asn Met Ala Val Gly Asn Met Ser Val Leu Leu Arg Ser Leu Pro Gly
                1045                1050                1055    
Glu Thr Glu Phe Leu Asn Ser Ser Ala
            1060                1065


<210> 22
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<220> 
<221> modified_base  
<222> 1
<223> n=Biotin conjugated cytosine

<400> 22
ntcaacgtgg ggggccgact ctcg                                        24

<210> 23
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<220> 
<221> modified_base  
<222> 1
<223> n=Biotin conjugated cytosine

<400> 23
ngagagtcgg ccccccacgt tgag                                        24

<210> 24
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 24
ctcaacgtgg ggggccgact ctcg                                        24

<210> 25
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 25
cgagagtcgg ccccccacgt tgag                                        24

<210> 26
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 26
ctcaacggac cacccagact atcg                                        24

<210> 27
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 27
cgatagtctg ggtggtccgt tgag                                        24

<210> 28
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<220> 
<221> modified_base  
<222> 1
<223> n=Biotin conjugated cytosine

<400> 28
nccctcatct tggggggccc acgagaccct ctg                              33

<210> 29
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<220> 
<221> modified_base  
<222> 1
<223> n=Biotin conjugated cytosine

<400> 29
nagggagtct cgtgggcccc ccaagatgag ggg                              33

<210> 30
<211> 35
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 30
aaaaaaaaaa gcttatgttc aactcgatga cccca                            35

<210> 31
<211> 69
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 31
aaaaaaaaaa agcttctaca gatcttcttc agaaataagt ttttgttcgg cactagagtt 60
gaggaattc                                                         69

<210> 32
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> myc tag

<400> 32
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu
 1               5                  10  


<210> 33
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 33
ttgctgagtc atgga                                                  15

<210> 34
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 34
aaactgacat caaaca                                                 16

<210> 35
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 35
aaattgggtg gtcagag                                                17

<210> 36
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 36
caactgaggt aaagag                                                 16

<210> 37
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 37
gtatgaacac ccatata                                                17

<210> 38
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 38
ttactgacat cattca                                                 16

<210> 39
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 39
tttatgaggt aatgtg                                                 16

<210> 40
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 40
aatttgagtc aaata                                                  15

<210> 41
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 41
tagctgaggt aattct                                                 16

<210> 42
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 42
cccttgggtg gtcgatg                                                17

<210> 43
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 43
atgcttggtg gtctttt                                                17

<210> 44
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 44
taaatgactc aaagc                                                  15

<210> 45
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 45
ttcctggctg ctcgggg                                                17

<210> 46
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 46
taagtgagtc aaacc                                                  15

<210> 47
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 47
gcaagtcctc ccaaggc                                                17

<210> 48
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 48
ggggtgggtg gtggttt                                                17

<210> 49
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 49
tagttgagtc attta                                                  15

<210> 50
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Oligonucleotide

<400> 50
gatttgactc agaaa                                                  15
