                         SEQUENCE LISTING

<110>  Centre for Addiction and Mental Health
 
<120>  Compositions And Methods For Treating Multiple Sclerosis

<130>  08920921WO

<140>  PCT/CA2013/000002
<141>  2013-01-04

<150>  US 61/583,448
<151>  2012-01-05

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GluR2 NT1-3-2

<400>  1

Tyr Tyr Gln Trp Asp Lys Phe Ala Tyr Leu Tyr Asp Ser Asp Arg Gly 
1               5                   10                  15      


Leu Ser Thr Leu Gln Ala Val Leu Asp Ser Ala Ala Glu Lys Lys 
            20                  25                  30      


<210>  2
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence of GluR2 amino terminus

<400>  2
atgcaaaaga ttatgcatat ttctgtcctc ctttctcctg ttttatgggg actgattttt       60

ggtgtctctt ctaacagcat acagataggg gggctatttc caaggggcgc tgatcaagaa      120

tacagtgcat ttcgggtagg gatggttcag ttttccactt cggagttcag actgacaccc      180

catatcgaca atttggaggt agccaacagt ttcgcagtca ccaatgcttt ctgctcccag      240

ttttcaagag gagtctacgc aatttttgga ttttatgaca agaagtctgt aaataccatc      300

acatcattct gtgggacact ccatgtgtcc ttcatcacac ctagcttccc aacagatggc      360

acacatccat ttgtcatcca gatgcgacct gacctcaaag gagcactcct tagcttgatt      420

gagtactacc aatgggacaa gttcgcatac ctctatgaca gtgacagagg cttatcaaca      480

ctgcaagctg ttctggattc tgctgcagag aagaagtggc aggtgactgc tatcaatgtg      540

gggaacatca acaatgacaa gaaagatgag acctacagat cgctctttca agatctggag      600

ttaaaaaaag aacggcgtgt aatcctggac tgtgaaaggg ataaagtaaa tgacattgtg      660

gaccaggtta ttaccattgg aaaacatgtt aaagggtacc attatatcat tgcaaatctg      720

ggattcactg atggggacct gctgaaaatt cagtttggag gagcaaatgt ctctggattt      780

cagattgtag actacgatga ttccctggtg tctaaattta tagaaagatg gtcaacactg      840

gaagagaaag aataccctgg agcacacaca gcgacaatta agtatacttc ggccctgacg      900

tatgatgctg tccaagtgat gactgaagca ttccgtaacc ttcggaagca gaggattgaa      960

atatcccgga gaggaaatgc aggggattgt ttggccaacc cagctgtgcc ctggggacaa     1020

ggggtcgaaa tagaaagggc cctcaagcag gttcaagttg aaggcctctc tggaaatata     1080

aagtttgacc agaatggaaa acgaataaac tacacaatta acatcatgga gctcaaaaca     1140

aatggacccc ggaagattgg gtactggagt gaagtggata aaatggttgt caccctaact     1200

gagctcccat caggaaatga cacgtctggg cttgaaaaca agactgtggt ggtcaccaca     1260

atattggaat ctccatatgt tatgatgaag aaaaatcatg aaatgcttga agggaatgag     1320

cgttacgagg gctactgtgt tgacttagct gcagaaattg ccaaacactg tgggttcaag     1380

tacaagctga ctattgttgg ggatggcaag tatggggcca gggatgccga caccaaaatt     1440

tggaatggta tggttggaga gcttgtctac gggaaagctg acattgcaat tgctccatta     1500

actatcactc tcgtgagaga agaggtgatt gacttctcca agcccttcat gagtcttgga     1560

atctctatca tgatcaagaa gcctcagaag tccaaaccag gagtgttttc ctttcttgat     1620

cctttagcct atgag                                                      1635


<210>  3
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V22-E545 of GluR2

<400>  3

Val Ser Ser Asn Ser Ile Gln Ile Gly Gly Leu Phe Pro Arg Gly Ala 
1               5                   10                  15      


Asp Gln Glu Tyr Ser Ala Phe Arg Val Gly Met Val Gln Phe Ser Thr 
            20                  25                  30          


Ser Glu Phe Arg Leu Thr Pro His Ile Asp Asn Leu Glu Val Ala Asn 
        35                  40                  45              


Ser Phe Ala Val Thr Asn Ala Phe Cys Ser Gln Phe Ser Arg Gly Val 
    50                  55                  60                  


Tyr Ala Ile Phe Gly Phe Tyr Asp Lys Lys Ser Val Asn Thr Ile Thr 
65                  70                  75                  80  


Ser Phe Cys Gly Thr Leu His Val Ser Phe Ile Thr Pro Ser Phe Pro 
                85                  90                  95      


Thr Asp Gly Thr His Pro Phe Val Ile Gln Met Arg Pro Asp Leu Lys 
            100                 105                 110         


Gly Ala Leu Leu Ser Leu Ile Glu Tyr Tyr Gln Trp Asp Lys Phe Ala 
        115                 120                 125             


Tyr Leu Tyr Asp Ser Asp Arg Gly Leu Ser Thr Leu Gln Ala Val Leu 
    130                 135                 140                 


Asp Ser Ala Ala Glu Lys Lys Trp Gln Val Thr Ala Ile Asn Val Gly 
145                 150                 155                 160 


Asn Ile Asn Asn Asp Lys Lys Asp Glu Thr Tyr Arg Ser Leu Phe Gln 
                165                 170                 175     


Asp Leu Glu Leu Lys Lys Glu Arg Arg Val Ile Leu Asp Cys Glu Arg 
            180                 185                 190         


Asp Lys Val Asn Asp Ile Val Asp Gln Val Ile Thr Ile Gly Lys His 
        195                 200                 205             


Val Lys Gly Tyr His Tyr Ile Ile Ala Asn Leu Gly Phe Thr Asp Gly 
    210                 215                 220                 


Asp Leu Leu Lys Ile Gln Phe Gly Gly Ala Asn Val Ser Gly Phe Gln 
225                 230                 235                 240 


Ile Val Asp Tyr Asp Asp Ser Leu Val Ser Lys Phe Ile Glu Arg Trp 
                245                 250                 255     


Ser Thr Leu Glu Glu Lys Glu Tyr Pro Gly Ala His Thr Ala Thr Ile 
            260                 265                 270         


Lys Tyr Thr Ser Ala Leu Thr Tyr Asp Ala Val Gln Val Met Thr Glu 
        275                 280                 285             


Ala Phe Arg Asn Leu Arg Lys Gln Arg Ile Glu Ile Ser Arg Arg Gly 
    290                 295                 300                 


Asn Ala Gly Asp Cys Leu Ala Asn Pro Ala Val Pro Trp Gly Gln Gly 
305                 310                 315                 320 


Val Glu Ile Glu Arg Ala Leu Lys Gln Val Gln Val Glu Gly Leu Ser 
                325                 330                 335     


Gly Asn Ile Lys Phe Asp Gln Asn Gly Lys Arg Ile Asn Tyr Thr Ile 
            340                 345                 350         


Asn Ile Met Glu Leu Lys Thr Asn Gly Pro Arg Lys Ile Gly Tyr Trp 
        355                 360                 365             


Ser Glu Val Asp Lys Met Val Val Thr Leu Thr Glu Leu Pro Ser Gly 
    370                 375                 380                 


Asn Asp Thr Ser Gly Leu Glu Asn Lys Thr Val Val Val Thr Thr Ile 
385                 390                 395                 400 


Leu Glu Ser Pro Tyr Val Met Met Lys Lys Asn His Glu Met Leu Glu 
                405                 410                 415     


Gly Asn Glu Arg Tyr Glu Gly Tyr Cys Val Asp Leu Ala Ala Glu Ile 
            420                 425                 430         


Ala Lys His Cys Gly Phe Lys Tyr Lys Leu Thr Ile Val Gly Asp Gly 
        435                 440                 445             


Lys Tyr Gly Ala Arg Asp Ala Asp Thr Lys Ile Trp Asn Gly Met Val 
    450                 455                 460                 


Gly Glu Leu Val Tyr Gly Lys Ala Asp Ile Ala Ile Ala Pro Leu Thr 
465                 470                 475                 480 


Ile Thr Leu Val Arg Glu Glu Val Ile Asp Phe Ser Lys Pro Phe Met 
                485                 490                 495     


Ser Leu Gly Ile Ser Ile Met Ile Lys Lys Pro Gln Lys Ser Lys Pro 
            500                 505                 510         


Gly Val Phe Ser Phe Leu Asp Pro Leu Ala Tyr Glu 
        515                 520                 


<210>  4
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G-Gpep-sc or G-Gpep-scrambled

<400>  4

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Ala Phe Asp Leu Ser 
1               5                   10                  15      


Gln Tyr Asp Leu Lys Trp Gln Val Asp Tyr Leu Lys Tyr Asp Tyr Gly 
            20                  25                  30          


Thr Ala Ser Glu Leu Arg Ala Ser Ala 
        35                  40      


<210>  5
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fragment 2 (Asp153 - Lys172) of GluR2 N-terminus

<400>  5

Asp Ser Asp Arg Gly Leu Ser Thr Leu Gln Ala Val Leu Asp Ser Ala 
1               5                   10                  15      


Ala Glu Lys Lys 
            20  


<210>  6
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (MOG) peptide 35-55

<400>  6

Met Glu Val Gly Trp Tyr Arg Ser Pro Phe Ser Arg Val Val His Leu 
1               5                   10                  15      


Tyr Arg Asn Gly Lys 
            20      


<210>  7
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fragment 1 (Tyr142 - Leu161) of GluR2 N-terminus

<400>  7

Tyr Tyr Gln Trp Asp Lys Phe Ala Tyr Leu Tyr Asp Ser Asp Arg Gly 
1               5                   10                  15      


Leu Ser Thr Leu 
            20  


