                         SEQUENCE LISTING

<110>  DUKE UNIVERSITY
       KORNBLUTH, Sally A.
       KUROKAWA, Manabu
       SPECTOR, Neil
       DEWHIRST, Mark
 
<120>  METHODS OF IDENTIFYING AND USING MDM2 INHIBITORS

<130>  5667-00102

<150>  US 61/567,944
<151>  2011-12-07

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  19
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  P53 human

<400>  1

Leu Ser Gln Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn 
1               5                   10                  15      


Asn Val Leu 
            


<210>  2
<211>  19
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  P73 human

<400>  2

Asp Gly Gly Thr Thr Phe Glu His Leu Trp Ser Ser Leu Glu Pro Asp 
1               5                   10                  15      


Ser Thr Tyr 
            


<210>  3
<211>  19
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  P63 human

<400>  3

Leu Ser Pro Glu Val Phe Gln His Ile Trp Asp Phe Leu Glu Gln Pro 
1               5                   10                  15      


Ile Cys Ser 
            


<210>  4
<211>  19
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  CAS/CSE1L human

<400>  4

Ile Gly Arg Glu Asp Phe Pro Gln Lys Trp Pro Asp Leu Leu Thr Glu 
1               5                   10                  15      


Met Val Asn 
            


<210>  5
<211>  19
<212>  PRT
<213>  D. melanogaster


<220>
<221>  misc_feature
<223>  CSE1

<400>  5

Ile Gly Lys Tyr Asp Phe Pro Lys Lys Trp Pro Gln Leu Ile Asp Glu 
1               5                   10                  15      


Met Val Glu 
            


<210>  6
<211>  19
<212>  PRT
<213>  S. cerevisiae


<220>
<221>  misc_feature
<223>  CSE1

<400>  6

Ile Ala Asp Ser Asp Phe Pro Asp Arg Trp Pro Thr Leu Leu Ser Asp 
1               5                   10                  15      


Leu Ala Ser 
            


<210>  7
<211>  19
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Huwe1

<400>  7

Asp Gly Thr Gly Glu Phe Leu Asp Ala Trp Leu Met Leu Val Glu Lys 
1               5                   10                  15      


Met Val Asn 
            


<210>  8
<211>  19
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Huwe1

<400>  8

Asp Gly Thr Gly Glu Phe Leu Asp Ala Trp Leu Met Leu Val Glu Lys 
1               5                   10                  15      


Met Val Asn 
            


<210>  9
<211>  19
<212>  PRT
<213>  Bos taurus


<220>
<221>  misc_feature
<223>  Huwe1

<400>  9

Asp Gly Thr Gly Glu Phe Leu Asp Ala Trp Leu Met Leu Val Glu Lys 
1               5                   10                  15      


Met Val Asn 
            


<210>  10
<211>  19
<212>  PRT
<213>  Danio rerio


<220>
<221>  misc_feature
<223>  Huwe1

<400>  10

Asp Gly Thr Gly Glu Phe Leu Asp Ala Trp Leu Met Leu Val Glu Lys 
1               5                   10                  15      


Met Val Asn 
            


<210>  11
<211>  19
<212>  PRT
<213>  Tribolium castaneum


<220>
<221>  misc_feature
<223>  Huwe1

<400>  11

Glu Gly Thr Ala Gly Phe Leu Asp Ala Trp Leu Met Leu Leu Glu Lys 
1               5                   10                  15      


Met Val Asn 
            


<210>  12
<211>  14
<212>  PRT
<213>  S. cerevisiae


<220>
<221>  misc_feature
<223>  TOM1

<400>  12

Asp Glu Ser Asn Gly Ile Leu Thr Leu Ser Cys Leu Ile Asn 
1               5                   10                  


<210>  13
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: MDM2-specific siRNA

<400>  13
caccucacag auuccagcuu cggaa                                             25


<210>  14
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: MDM2-scrambled siRNA control

<400>  14
cacacacuua ggacccuucg ucgaa                                             25


<210>  15
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: MDM2-specific shRNA number 1

<400>  15
gattccagag agtcatgtgt t                                                 21


<210>  16
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: MDM2-specific shRNA number 2

<400>  16
ttgaagttat taaagtctgt t                                                 21


<210>  17
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: MDM2 shRNA control

<400>  17
ctgtgctgta ggtgaaactg t                                                 21

 

