                         SEQUENCE LISTING

<110>  ImmunoQure AG
 
<120>  Method of providing monoclonal antibodies with desired 
       specificity

<130>  IM11A01/P-WO

<150>  EP 11 195 952.4
<151>  2011-12-28

<150>  US 61/580,837
<151>  2011-12-28

<160>  81    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide (primer) 6F

<400>  1
tgcaggctgt gggaactcca                                                   20


<210>  2
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide (primer) 6R

<400>  2
agaaaaagag ctgtaccctg tg                                                22


<210>  3
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide (primer) 3R

<400>  3
tgcaaggaag aggggcgtca gc                                                22


<210>  4
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide (primer) 49300F

<400>  4
tccaccacaa gccgaggaga t                                                 21


<210>  5
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide (primer) 49622R

<400>  5
acgggctcct caaacaccac t                                                 21


<210>  6
<211>  378
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(378)
<223>  9A2-VH variable heavy chain (VH) sequence; 9A2: IgG1, kappa

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(345)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  6
gag gtg caa ttg gag gag tct ggc gga ggc ttg gtt cag cct gga ggg         48
Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc ccc ttc agc aac tat         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Phe Ser Asn Tyr           
            20                  25                  30                    

gaa atg aat tgg gtc cgc cag gct ccc ggg aag gga ctg gag tgg att        144
Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile           
        35                  40                  45                        

tca tac att agt gtg agc ggt ggt ccc gct cac tac gca gac tct gtg        192
Ser Tyr Ile Ser Val Ser Gly Gly Pro Ala His Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cga ttc acc att tcc aga gac gac gcc aca aag tca ctg ttt        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Thr Lys Ser Leu Phe           
65                  70                  75                  80            

ctg caa atg aac cgc ctg aga gcc gac gac acg gca gtt tat tac tgt        288
Leu Gln Met Asn Arg Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gtg cgc cgc gaa tat gtc act ggc cgc aat tac aac tac tac ccc tac        336
Val Arg Arg Glu Tyr Val Thr Gly Arg Asn Tyr Asn Tyr Tyr Pro Tyr           
            100                 105                 110                   

atg gac gtc tgg ggc act ggg acc acg gtc acc gtc tcc cca                378
Met Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Pro                   
        115                 120                 125                       


<210>  7
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  7

Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Phe Ser Asn Tyr 
            20                  25                  30          


Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ser Tyr Ile Ser Val Ser Gly Gly Pro Ala His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Thr Lys Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Arg Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Arg Glu Tyr Val Thr Gly Arg Asn Tyr Asn Tyr Tyr Pro Tyr 
            100                 105                 110         


Met Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Pro 
        115                 120                 125     


<210>  8
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(321)
<223>  9A2-VL variable light chain (VL) sequence, kappa type

<220>
<221>  V_region
<222>  (70)..(102)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (148)..(168)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (265)..(291)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  8
gac atc cag atg acc cag tct ccg tcc tcc ctg tct gct tct gtt ggg         48
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gac aga gtc acc atc act tgc cgg gca agt cag acc ata agt gat tat         96
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Ser Asp Tyr           
            20                  25                  30                    

tta aat tgg tac cag cac aaa cca ggg gaa gcc cct aaa ctc cta atc        144
Leu Asn Trp Tyr Gln His Lys Pro Gly Glu Ala Pro Lys Leu Leu Ile           
        35                  40                  45                        

tat tct gca tcc acc ttg caa cgt ggg gtg cct tca cgg ttc agt ggc        192
Tyr Ser Ala Ser Thr Leu Gln Arg Gly Val Pro Ser Arg Phe Ser Gly           
    50                  55                  60                            

agt gga tct ggg aca gat ttc gtt ttc acc att agt agt ctg cag tct        240
Ser Gly Ser Gly Thr Asp Phe Val Phe Thr Ile Ser Ser Leu Gln Ser           
65                  70                  75                  80            

gat gat ttt gcg act tac tac tgt caa cag act tcc agt acc gcc ctc        288
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Ser Ser Thr Ala Leu           
                85                  90                  95                

act ttc ggc gga ggg acc aag gtg gag gtc aaa                            321
Thr Phe Gly Gly Gly Thr Lys Val Glu Val Lys                               
            100                 105                                       


<210>  9
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  9

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Ser Asp Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln His Lys Pro Gly Glu Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Gln Arg Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Val Phe Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Ser Ser Thr Ala Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Val Lys 
            100                 105         


<210>  10
<211>  993
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(990)
<223>  9A2-CH constant heavy chain (CH) sequence

<400>  10
gcc tcc acc aag ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag         48
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys           
1               5                   10                  15                

agc acc tct ggg ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac         96
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr           
            20                  25                  30                    

ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc        144
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser           
        35                  40                  45                        

ggc gtg cac acc ttc ccg gct gtc cta cag tcc tca gga ctc tac tcc        192
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser           
    50                  55                  60                            

ctc agc agc gtg gtg acc gtg ccc tcc agc agc ttg ggc acc cag acc        240
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr           
65                  70                  75                  80            

tac atc tgc aac gtg aat cac aag ccc agc aac acc aag gtg gac aag        288
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys           
                85                  90                  95                

aaa gtt gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc        336
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys           
            100                 105                 110                   

cca gca cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca        384
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro           
        115                 120                 125                       

aaa ccc aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc        432
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys           
    130                 135                 140                           

gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg        480
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp           
145                 150                 155                 160           

tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag        528
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu           
                165                 170                 175               

gag cag tac aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg        576
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu           
            180                 185                 190                   

cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac        624
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn           
        195                 200                 205                       

aaa gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc aaa ggg        672
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly           
    210                 215                 220                           

cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gat gag        720
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu           
225                 230                 235                 240           

ctg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat        768
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr           
                245                 250                 255               

ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac        816
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn           
            260                 265                 270                   

aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc        864
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe           
        275                 280                 285                       

ctc tac agc aag ctc acc gtg gac aag agc agg tgg cag cag ggg aac        912
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn           
    290                 295                 300                           

gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg        960
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr           
305                 310                 315                 320           

cag aag agc ctc tcc ctg tct ccg ggt aaa tga                            993
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                                   
                325                 330                                   


<210>  11
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  11

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  12
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(321)
<223>  9A2-CL constant kappa chain (CL) sequence

<220>
<221>  misc_feature
<222>  (260)..(260)
<223>  not sequenced but obtained from database

<220>
<221>  misc_feature
<222>  (298)..(324)
<223>  not sequenced but obtained from database

<400>  12
cga act gtg gct gca cca tct gtc ttc atc ttc ccg cca tct gat gag         48
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu           
1               5                   10                  15                

cag ttg aaa tct gga act gcc tct gtt gtg tgc ctg ctg aat aac ttc         96
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe           
            20                  25                  30                    

tat ccc aga gag gcc aaa gta cag tgg aag gtg gat aac gcc ctc caa        144
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln           
        35                  40                  45                        

tcg ggt aac tcc cag gag agt gtc aca gag cag gac agc aag gac agc        192
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser           
    50                  55                  60                            

acc tac agc ctc agc agc acc ctg acg ctg agc aaa gca gac tac gag        240
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu           
65                  70                  75                  80            

aaa cac aaa gtc tac gcc tgc gaa gtc acc cat cag ggc ctg agc tcg        288
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser           
                85                  90                  95                

ccc gtc aca aag agc ttc aac agg gga gag tgt tag                        324
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys                               
            100                 105                                       


<210>  13
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  13

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  14
<211>  387
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(387)
<223>  17E3-VH variable heavy chain (VH) sequence; 17E3: IgG1, kappa

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(354)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  14
cag gtg caa ctg gtc cag tct ggg gct gaa gtg gcg aag cct ggg gcc         48
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Ala Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aga ctt tcc tgc aag gcg tct gga ttc agt ttt atc aag tat         96
Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Phe Ser Phe Ile Lys Tyr           
            20                  25                  30                    

tat atg cac tgg gtg cga cag gcc cct gga caa ggg ctt gag tgg atg        144
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met           
        35                  40                  45                        

ggg gtc atc gag ccc acc ggt ggt ggc aca agc tcc gca cag aag ttc        192
Gly Val Ile Glu Pro Thr Gly Gly Gly Thr Ser Ser Ala Gln Lys Phe           
    50                  55                  60                            

cga gac aga gtc acc ctg agc agg gac acg tcc acg gcc act gtc cat        240
Arg Asp Arg Val Thr Leu Ser Arg Asp Thr Ser Thr Ala Thr Val His           
65                  70                  75                  80            

ttg gaa gtg agt agg ctg act ctt gag gac acg ggc att tat ttc tgt        288
Leu Glu Val Ser Arg Leu Thr Leu Glu Asp Thr Gly Ile Tyr Phe Cys           
                85                  90                  95                

gtg aga gac tcc ata tat tgt aaa cat ggg acc tgt cat cgg act gtg        336
Val Arg Asp Ser Ile Tyr Cys Lys His Gly Thr Cys His Arg Thr Val           
            100                 105                 110                   

atc gat gct ttt gac att tgg ggc caa ggg acg gcg gtc acc gtc tct        384
Ile Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Ala Val Thr Val Ser           
        115                 120                 125                       

tca                                                                    387
Ser                                                                       
                                                                          


<210>  15
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  15

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Phe Ser Phe Ile Lys Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Glu Pro Thr Gly Gly Gly Thr Ser Ser Ala Gln Lys Phe 
    50                  55                  60                  


Arg Asp Arg Val Thr Leu Ser Arg Asp Thr Ser Thr Ala Thr Val His 
65                  70                  75                  80  


Leu Glu Val Ser Arg Leu Thr Leu Glu Asp Thr Gly Ile Tyr Phe Cys 
                85                  90                  95      


Val Arg Asp Ser Ile Tyr Cys Lys His Gly Thr Cys His Arg Thr Val 
            100                 105                 110         


Ile Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Ala Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  16
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(324)
<223>  17E3-VL variable light chain (VL) sequence, kappa type

<220>
<221>  V_region
<222>  (70)..(102)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (148)..(168)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (265)..(294)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  16
gac atc cag atg acc cag tct cca tcc tcc ctg tct gca tca gta gga         48
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gac cga gtc acc atc act tgc cgg tca agt cag gac ata aaa aat gat         96
Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Asp Ile Lys Asn Asp           
            20                  25                  30                    

tta gcc tgg tat cag cag aag cca gga aaa gcc cct gag cgc ctg atc        144
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Glu Arg Leu Ile           
        35                  40                  45                        

tat gct gca tcc aat ttg cag agt ggg gtc cca tca agg ttc agc ggc        192
Tyr Ala Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly           
    50                  55                  60                            

agt ggc tct ggg aca gaa ttc agt ctt aca atc agt ggc ctg cag cct        240
Ser Gly Ser Gly Thr Glu Phe Ser Leu Thr Ile Ser Gly Leu Gln Pro           
65                  70                  75                  80            

gaa gat ttt gca act tat tac tgt cta cag cat aat agt tac cct ctg        288
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Leu           
                85                  90                  95                

ctc act ttc ggc gga ggg acc aag gtg gag atc aaa                        324
Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys                           
            100                 105                                       


<210>  17
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  17

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Asp Ile Lys Asn Asp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Glu Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Ser Leu Thr Ile Ser Gly Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Leu 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  18
<211>  993
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(990)
<223>  17E3-CH constant heavy chain (CH) sequence

<400>  18
gcc tcc acc aag ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag         48
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys           
1               5                   10                  15                

agc acc tct ggg ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac         96
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr           
            20                  25                  30                    

ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc        144
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser           
        35                  40                  45                        

ggc gtg cac acc ttc ccg gct gtc cta cag tcc tca gga ctc tac tcc        192
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser           
    50                  55                  60                            

ctc agc agc gtg gtg acc gtg ccc tcc agc agc ttg ggc acc cag acc        240
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr           
65                  70                  75                  80            

tac atc tgc aac gtg aat cac aag ccc agc aac acc aag gtg gac aag        288
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys           
                85                  90                  95                

aaa gtt gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc        336
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys           
            100                 105                 110                   

cca gca cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca        384
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro           
        115                 120                 125                       

aaa ccc aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc        432
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys           
    130                 135                 140                           

gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg        480
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp           
145                 150                 155                 160           

tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag        528
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu           
                165                 170                 175               

gag cag tac aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg        576
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu           
            180                 185                 190                   

cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac        624
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn           
        195                 200                 205                       

aaa gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc aaa ggg        672
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly           
    210                 215                 220                           

cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gat gag        720
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu           
225                 230                 235                 240           

ctg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat        768
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr           
                245                 250                 255               

ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac        816
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn           
            260                 265                 270                   

aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc        864
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe           
        275                 280                 285                       

ctc tac agc aag ctc acc gtg gac aag agc agg tgg cag cag ggg aac        912
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn           
    290                 295                 300                           

gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg        960
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr           
305                 310                 315                 320           

cag aag agc ctc tcc ctg tct ccg ggt aaa tga                            993
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                                   
                325                 330                                   


<210>  19
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  19

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  20
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(321)
<223>  17E3-CL constant kappa chain (CL) sequence

<220>
<221>  misc_feature
<222>  (298)..(324)
<223>  not sequenced but obtained from database

<400>  20
cga act gtg gct gca cca tct gtc ttc atc ttc ccg cca tct gat gag         48
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu           
1               5                   10                  15                

cag ttg aaa tct gga act gcc tct gtt gtg tgc ctg ctg aat aac ttc         96
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe           
            20                  25                  30                    

tat ccc aga gag gcc aaa gta cag tgg aag gtg gat aac gcc ctc caa        144
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln           
        35                  40                  45                        

tcg ggt aac tcc cag gag agt gtc aca gag cag gac agc aag gac agc        192
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser           
    50                  55                  60                            

acc tac agc ctc agc agc acc ctg acg ctg agc aaa gca gac tac gag        240
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu           
65                  70                  75                  80            

aaa cac aaa gtc tac gcc tgc gaa gtc acc cat cag ggc ctg agc tcg        288
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser           
                85                  90                  95                

ccc gtc aca aag agc ttc aac agg gga gag tgt tag                        324
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys                               
            100                 105                                       


<210>  21
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  21

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  22
<211>  372
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(372)
<223>  24D3-VH variable heavy chain (VH) sequence; 24D3: IgG1, lambda

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(204)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (301)..(339)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  22
gag gtg aag ttg gag gag tct ggg gga gac ctg gta aag cct ggg ggg         48
Glu Val Lys Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly           
1               5                   10                  15                

tct ctt aga ctc tcc tgt gta gcc tct gga ttc act ttc ggc acc gcc         96
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Gly Thr Ala           
            20                  25                  30                    

tgg atg agc tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtt        144
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

ggc cgt att agc aac aaa gac act ggt ggg aga ata gac tac gcc gca        192
Gly Arg Ile Ser Asn Lys Asp Thr Gly Gly Arg Ile Asp Tyr Ala Ala           
    50                  55                  60                            

ccc gtg aga ggc aga ttc gcc atc tca aga gat gat tcg aaa gcc acc        240
Pro Val Arg Gly Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ala Thr           
65                  70                  75                  80            

ctg ttt ctg caa atg aac agc ctg aaa acc gag gac aca gcc gtg tat        288
Leu Phe Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr           
                85                  90                  95                

ttt tgt act aca aat ttt tac gat gtt ttg act ggt gat cat gtt gac        336
Phe Cys Thr Thr Asn Phe Tyr Asp Val Leu Thr Gly Asp His Val Asp           
            100                 105                 110                   

tat tgg ggc cag gga acc gtg gtc gtc gtc tcc tca                        372
Tyr Trp Gly Gln Gly Thr Val Val Val Val Ser Ser                           
        115                 120                                           


<210>  23
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  23

Glu Val Lys Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Gly Thr Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Ser Asn Lys Asp Thr Gly Gly Arg Ile Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Arg Gly Arg Phe Ala Ile Ser Arg Asp Asp Ser Lys Ala Thr 
65                  70                  75                  80  


Leu Phe Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Phe Cys Thr Thr Asn Phe Tyr Asp Val Leu Thr Gly Asp His Val Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Val Val Val Val Ser Ser 
        115                 120                 


<210>  24
<211>  318
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(318)
<223>  24D3-VL variable light chain (VL) sequence, lambda type

<220>
<221>  V_region
<222>  (67)..(99)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (145)..(165)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (262)..(288)
<223>  complementarity determining region (CDR) VL-CDR2

<400>  24
tcc tat gag ctg aca cag cca ccc tcg gtg tca gtg tcc cca gga gag         48
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Glu           
1               5                   10                  15                

acg gcc agg atc ccc tgc tct gga gaa aca ttg cca aag aaa ctt gtt         96
Thr Ala Arg Ile Pro Cys Ser Gly Glu Thr Leu Pro Lys Lys Leu Val           
            20                  25                  30                    

tat tgg tat cag cag aag cca ggc cag gcc cct gta ttg atg att tat        144
Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Met Ile Tyr           
        35                  40                  45                        

aaa gac agt gag agg ccc tca cga ata tct gag cga ttc tct ggc tcc        192
Lys Asp Ser Glu Arg Pro Ser Arg Ile Ser Glu Arg Phe Ser Gly Ser           
    50                  55                  60                            

aac tca ggg aca atg gcc tcc ttg acc atc agt gga gtc cag gca gaa        240
Asn Ser Gly Thr Met Ala Ser Leu Thr Ile Ser Gly Val Gln Ala Glu           
65                  70                  75                  80            

gac gag gct gac tat tac tgt caa aca tca gac agc agt ggt gtg gtt        288
Asp Glu Ala Asp Tyr Tyr Cys Gln Thr Ser Asp Ser Ser Gly Val Val           
                85                  90                  95                

ttc ggc gga ggg acc aag ttg acc gtc tta                                318
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu                                   
            100                 105                                       


<210>  25
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  25

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Glu 
1               5                   10                  15      


Thr Ala Arg Ile Pro Cys Ser Gly Glu Thr Leu Pro Lys Lys Leu Val 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Met Ile Tyr 
        35                  40                  45              


Lys Asp Ser Glu Arg Pro Ser Arg Ile Ser Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Thr Met Ala Ser Leu Thr Ile Ser Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Thr Ser Asp Ser Ser Gly Val Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105     


<210>  26
<211>  993
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(990)
<223>  24D3-CH constant heavy chain (CH) sequence

<400>  26
gcc tcc acc aag ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag         48
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys           
1               5                   10                  15                

agc acc tct ggg ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac         96
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr           
            20                  25                  30                    

ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc        144
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser           
        35                  40                  45                        

ggc gtg cac acc ttc ccg gct gtc cta cag tcc tca gga ctc tac tcc        192
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser           
    50                  55                  60                            

ctc agc agc gtg gtg acc gtg ccc tcc agc agc ttg ggc acc cag acc        240
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr           
65                  70                  75                  80            

tac atc tgc aac gtg aat cac aag ccc agc aac acc aag gtg gac aag        288
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys           
                85                  90                  95                

aaa gtt gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc        336
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys           
            100                 105                 110                   

cca gca cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca        384
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro           
        115                 120                 125                       

aaa ccc aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc        432
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys           
    130                 135                 140                           

gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg        480
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp           
145                 150                 155                 160           

tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag        528
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu           
                165                 170                 175               

gag cag tac aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg        576
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu           
            180                 185                 190                   

cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac        624
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn           
        195                 200                 205                       

aaa gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc aaa ggg        672
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly           
    210                 215                 220                           

cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gat gag        720
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu           
225                 230                 235                 240           

ctg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat        768
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr           
                245                 250                 255               

ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac        816
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn           
            260                 265                 270                   

aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc        864
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe           
        275                 280                 285                       

ctc tac agc aag ctc acc gtg gac aag agc agg tgg cag cag ggg aac        912
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn           
    290                 295                 300                           

gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg        960
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr           
305                 310                 315                 320           

cag aag agc ctc tcc ctg tct ccg ggt aaa tga                            993
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                                   
                325                 330                                   


<210>  27
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  27

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  28
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(318)
<223>  24D3-CL constant lambda chain (CL) sequence

<220>
<221>  misc_feature
<222>  (250)..(321)
<223>  not sequenced but obtained from database

<400>  28
ggt cag ccc aag gct gcc ccc tcg gtc act ctg ttc ccg ccc tcc tct         48
Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser           
1               5                   10                  15                

gag gag ctt caa gcc aac aag gcc aca ctg gtg tgt ctc ata agt gac         96
Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp           
            20                  25                  30                    

ttc tac ccg gga gcc gtg aca gtg gcc tgg aag gca gat agc agc ccc        144
Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro           
        35                  40                  45                        

gtc aag gcg gga gtg gag acc acc aca ccc tcc aaa caa agc aac aac        192
Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn           
    50                  55                  60                            

aag tac gcg gcc agc agc tat ctg agc ctg acg cct gag cag tgg aag        240
Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys           
65                  70                  75                  80            

tcc cac aga agc tac agc tgc cag gtc acg cat gaa ggg agc acc gtg        288
Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val           
                85                  90                  95                

gag aag aca gtg gcc cct aca gaa tgt tca tag                            321
Glu Lys Thr Val Ala Pro Thr Glu Cys Ser                                   
            100                 105                                       


<210>  29
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  29

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  30
<211>  372
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(372)
<223>  30G1-VH variable heavy chain (VH) sequence; 30G1: IgG1, kappa

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(339)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  30
gag gtg cag ctg ttg gaa tcg ggg gga ggc ttg gtt cag ccg ggg ggg         48
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttt agt acc tat         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr           
            20                  25                  30                    

gcc atg agt tgg gtc cgc cag gct cca ggg aag ggg ctg gag tgg gtc        144
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

tca act ata act agc agt ggt ggt gcc act tac cac gca gac tcc gtg        192
Ser Thr Ile Thr Ser Ser Gly Gly Ala Thr Tyr His Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cgg ctc acc atc tcc aga gac aat tcc aag aac acg ctg tat        240
Lys Gly Arg Leu Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr           
65                  70                  75                  80            

ttg gag atg aac agc ctg aga gtc gag gac acg gcc gtc tat tac tgt        288
Leu Glu Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aaa gat tgg gga aga acg gtt tat gcg gtg atc aag gac ctt gac        336
Ala Lys Asp Trp Gly Arg Thr Val Tyr Ala Val Ile Lys Asp Leu Asp           
            100                 105                 110                   

atc tgg ggc cag gga acc ctg gtc acc gtc tcc tca                        372
Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser                           
        115                 120                                           


<210>  31
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  31

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Thr Ser Ser Gly Gly Ala Thr Tyr His Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Leu Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Trp Gly Arg Thr Val Tyr Ala Val Ile Lys Asp Leu Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  32
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(324)
<223>  30G1-VL variable light chain (VL) sequence, kappa type

<220>
<221>  V_region
<222>  (70)..(102)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (148)..(168)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (265)..(294)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  32
gaa att gtg atg aca cag tct cca gcc atc ctg tct gtg tct cca ggg         48
Glu Ile Val Met Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly           
1               5                   10                  15                

gaa aga gcc acc ctc tcc tgc agg gcc agt cag agt gtt agc aac tac         96
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Tyr           
            20                  25                  30                    

tta gcc tgg ttc caa caa aag cct ggc cag gct ccc agg ctc ctc atc        144
Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile           
        35                  40                  45                        

tat gac aca tct aag agg gcc act ggc acc ccc gcc agg ttc agt ggc        192
Tyr Asp Thr Ser Lys Arg Ala Thr Gly Thr Pro Ala Arg Phe Ser Gly           
    50                  55                  60                            

agt ggg tct ggg aca gac ttc act ctc acc atc agc agc cta gag cct        240
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro           
65                  70                  75                  80            

gaa gat ttt gca gtt tat ttc tgt cag cag cgt agc gac tgg cct cag        288
Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Arg Ser Asp Trp Pro Gln           
                85                  90                  95                

tac act ttt ggc cag ggg acc aaa ctg gag atc aaa                        324
Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys                           
            100                 105                                       


<210>  33
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  33

Glu Ile Val Met Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Thr Ser Lys Arg Ala Thr Gly Thr Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Arg Ser Asp Trp Pro Gln 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  34
<211>  993
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(990)
<223>  30G1-CH constant heavy chain (CH) sequence

<400>  34
gcc tcc acc aag ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag         48
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys           
1               5                   10                  15                

agc acc tct ggg ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac         96
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr           
            20                  25                  30                    

ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc        144
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser           
        35                  40                  45                        

ggc gtg cac acc ttc ccg gct gtc cta cag tcc tca gga ctc tac tcc        192
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser           
    50                  55                  60                            

ctc agc agc gtg gtg acc gtg ccc tcc agc agc ttg ggc acc cag acc        240
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr           
65                  70                  75                  80            

tac atc tgc aac gtg aat cac aag ccc agc aac acc aag gtg gac aag        288
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys           
                85                  90                  95                

aaa gtt gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc        336
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys           
            100                 105                 110                   

cca gca cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca        384
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro           
        115                 120                 125                       

aaa ccc aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc        432
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys           
    130                 135                 140                           

gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg        480
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp           
145                 150                 155                 160           

tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag        528
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu           
                165                 170                 175               

gag cag tac aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg        576
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu           
            180                 185                 190                   

cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac        624
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn           
        195                 200                 205                       

aaa gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc aaa ggg        672
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly           
    210                 215                 220                           

cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gat gag        720
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu           
225                 230                 235                 240           

ctg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat        768
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr           
                245                 250                 255               

ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac        816
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn           
            260                 265                 270                   

aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc        864
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe           
        275                 280                 285                       

ctc tac agc aag ctc acc gtg gac aag agc agg tgg cag cag ggg aac        912
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn           
    290                 295                 300                           

gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg        960
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr           
305                 310                 315                 320           

cag aag agc ctc tcc ctg tct ccg ggt aaa tga                            993
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                                   
                325                 330                                   


<210>  35
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  35

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  36
<211>  324
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(321)
<223>  30G1-CL constant kappa chain (CL) sequence

<220>
<221>  misc_feature
<222>  (248)..(324)
<223>  not sequenced but obtained from database

<400>  36
cga act gtg gct gca cca tct gtc ttc atc ttc ccg cca tct gat gag         48
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu           
1               5                   10                  15                

cag ttg aaa tct gga act gcc tct gtt gtg tgc ctg ctg aat aac ttc         96
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe           
            20                  25                  30                    

tat ccc aga gag gcc aaa gta cag tgg aag gtg gat aac gcc ctc caa        144
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln           
        35                  40                  45                        

tcg ggt aac tcc cag gag agt gtc aca gag cag gac agc aag gac agc        192
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser           
    50                  55                  60                            

acc tac agc ctc agc agc acc ctg acg ctg agc aaa gca gac tac gag        240
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu           
65                  70                  75                  80            

aaa cac aaa gtc tac gcc tgc gaa gtc acc cat cag ggc ctg agc tcg        288
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser           
                85                  90                  95                

ccc gtc aca aag agc ttc aac agg gga gag tgt tag                        324
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys                               
            100                 105                                       


<210>  37
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  37

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  38
<211>  378
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(378)
<223>  35G11-VH variable heavy chain (VH) sequence; 35G11: IgG4, lambda

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(345)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  38
cag gtg cag ctg gtt caa tct ggg tct gag ttg agg agg cct ggg gcc         48
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Arg Arg Pro Gly Ala           
1               5                   10                  15                

tca gtg aac att tcc tgc aag gct tct ggt tac ggc ttc aat act tat         96
Ser Val Asn Ile Ser Cys Lys Ala Ser Gly Tyr Gly Phe Asn Thr Tyr           
            20                  25                  30                    

gct atg aat tgg gtg cga cag gcc cct gga caa ggg cct gag tgg atg        144
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met           
        35                  40                  45                        

gga tgg atc aac acc gac act ggg gac cca acg tac gcc cag ggg ttc        192
Gly Trp Ile Asn Thr Asp Thr Gly Asp Pro Thr Tyr Ala Gln Gly Phe           
    50                  55                  60                            

acg gga cgg ttt gcc ttc ttc ttg gac acg tct gcc agc acg gca ttt        240
Thr Gly Arg Phe Ala Phe Phe Leu Asp Thr Ser Ala Ser Thr Ala Phe           
65                  70                  75                  80            

ctg cag atc act cgc cta acg ggt gag gac act gcc gtg tat ttc tgt        288
Leu Gln Ile Thr Arg Leu Thr Gly Glu Asp Thr Ala Val Tyr Phe Cys           
                85                  90                  95                

gcg aga act cgg aac aac tgg aac ggc gtt tac tat cac tac tcc ggt        336
Ala Arg Thr Arg Asn Asn Trp Asn Gly Val Tyr Tyr His Tyr Ser Gly           
            100                 105                 110                   

ttg gac gtc tgg ggc caa ggg acc acg gtc acc gtc tcc tca                378
Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser                   
        115                 120                 125                       


<210>  39
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  39

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Arg Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Asn Ile Ser Cys Lys Ala Ser Gly Tyr Gly Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asp Thr Gly Asp Pro Thr Tyr Ala Gln Gly Phe 
    50                  55                  60                  


Thr Gly Arg Phe Ala Phe Phe Leu Asp Thr Ser Ala Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Ile Thr Arg Leu Thr Gly Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Thr Arg Asn Asn Trp Asn Gly Val Tyr Tyr His Tyr Ser Gly 
            100                 105                 110         


Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  40
<211>  330
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(330)
<223>  35G11-VL variable light chain (VL), lambda type

<220>
<221>  V_region
<222>  (67)..(105)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (151)..(171)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (268)..(300)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  40
cag tct gtg ctg act cag cct ccc tct gcg tct ggg acc ccc ggg cag         48
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln           
1               5                   10                  15                

acg gtc acc atc tcc tgt tct gga agc agc ccc aac ctc gga gac aat         96
Thr Val Thr Ile Ser Cys Ser Gly Ser Ser Pro Asn Leu Gly Asp Asn           
            20                  25                  30                    

tat gta tac tgg tac cac caa gtc cca gga acg gcc ccc aaa ctc ctc        144
Tyr Val Tyr Trp Tyr His Gln Val Pro Gly Thr Ala Pro Lys Leu Leu           
        35                  40                  45                        

att ttt agg aat act cag cgg ccc tca ggg gtc act gac cga ttc tct        192
Ile Phe Arg Asn Thr Gln Arg Pro Ser Gly Val Thr Asp Arg Phe Ser           
    50                  55                  60                            

ggc tcc aag tat ggc acc tca gcc tcc ctg gcc ata agt gat ctc cgg        240
Gly Ser Lys Tyr Gly Thr Ser Ala Ser Leu Ala Ile Ser Asp Leu Arg           
65                  70                  75                  80            

tcc gac gat gaa ggt gat ttt tac tgt gct tcg tgg gat gac cgc ctg        288
Ser Asp Asp Glu Gly Asp Phe Tyr Cys Ala Ser Trp Asp Asp Arg Leu           
                85                  90                  95                

agt cgt ctg gtg ttc ggc gga ggg acc aag ctg acc gtc cta                330
Ser Arg Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu                   
            100                 105                 110                   


<210>  41
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  41

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Ser Gly Ser Ser Pro Asn Leu Gly Asp Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr His Gln Val Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Phe Arg Asn Thr Gln Arg Pro Ser Gly Val Thr Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Tyr Gly Thr Ser Ala Ser Leu Ala Ile Ser Asp Leu Arg 
65                  70                  75                  80  


Ser Asp Asp Glu Gly Asp Phe Tyr Cys Ala Ser Trp Asp Asp Arg Leu 
                85                  90                  95      


Ser Arg Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  42
<211>  984
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(981)
<223>  35G11-CH constant heavy chain (CH) sequence

<400>  42
gct tcc acc aag ggc cca tcc gtc ttc ccc ctg gcg ccc tgc tcc agg         48
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg           
1               5                   10                  15                

agc acc tcc gag agc aca gcc gcc ctg ggc tgc ctg gtc aag gac tac         96
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr           
            20                  25                  30                    

ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc        144
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser           
        35                  40                  45                        

ggc gtg cac acc ttc ccg gct gtc cta cag tcc tca gga ctc tac tcc        192
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser           
    50                  55                  60                            

ctc agc agc gtg gtg acc gtg ccc tcc agc agc ttg ggc acg aag acc        240
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr           
65                  70                  75                  80            

tac acc tgc aac gta gat cac aag ccc agc aac acc aag gtg gac aag        288
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys           
                85                  90                  95                

aga gtt gag tcc aaa tat ggt ccc cca tgc cca tca tgc cca gca cct        336
Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro           
            100                 105                 110                   

gag ttc ctg ggg gga cca tca gtc ttc ctg ttc ccc cca aaa ccc aag        384
Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys           
        115                 120                 125                       

gac act ctc atg atc tcc cgg acc cct gag gtc acg tgc gtg gtg gtg        432
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val           
    130                 135                 140                           

gac gtg agc cag gaa gac ccc gag gtc cag ttc aac tgg tac gtg gat        480
Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp           
145                 150                 155                 160           

ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag ttc        528
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe           
                165                 170                 175               

aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag gac        576
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp           
            180                 185                 190                   

tgg ctg aac ggc aag gag tac aag tgc aag gtc tcc aac aaa ggc ctc        624
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu           
        195                 200                 205                       

ccg tcc tcc atc gag aaa acc atc tcc aaa gcc aaa ggg cag ccc cga        672
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg           
    210                 215                 220                           

gag cca cag gtg tac acc ctg ccc cca tcc cag gag gag atg acc aag        720
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys           
225                 230                 235                 240           

aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tac ccc agc gac        768
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp           
                245                 250                 255               

atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac aag        816
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys           
            260                 265                 270                   

acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc        864
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser           
        275                 280                 285                       

agg cta acc gtg gac aag agc agg tgg cag gag ggg aat gtc ttc tca        912
Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser           
    290                 295                 300                           

tgc tcc gtg atg cat gag gct ctg cac aac cac tac aca cag aag agc        960
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser           
305                 310                 315                 320           

ctc tcc ctg tct ctg ggt aaa tga                                        984
Leu Ser Leu Ser Leu Gly Lys                                               
                325                                                       


<210>  43
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  43

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  44
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(318)
<223>  35G11-CL constant lambda chain (CL) sequence

<220>
<221>  variation
<222>  (211)..(213)
<223>  tac may be also tat

<220>
<221>  misc_feature
<222>  (250)..(321)
<223>  not sequenced but obtained from database

<400>  44
ggt cag ccc aag gct gcc ccc tcg gtc act ctg ttc ccg ccc tcc tct         48
Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser           
1               5                   10                  15                

gag gag ctt caa gcc aac aag gcc aca ctg gtg tgt ctc ata agt gac         96
Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp           
            20                  25                  30                    

ttc tac ccg gga gcc gtg aca gtg gcc tgg aag gca gat agc agc ccc        144
Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro           
        35                  40                  45                        

gtc aag gcg gga gtg gag acc acc aca ccc tcc aaa caa agc aac aac        192
Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn           
    50                  55                  60                            

aag tac gcg gcc agc agc tac ctg agc ctg acg cct gag cag tgg aag        240
Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys           
65                  70                  75                  80            

tcc cac aga agc tac agc tgc cag gtc acg cat gaa ggg agc acc gtg        288
Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val           
                85                  90                  95                

gag aag aca gtg gcc cct aca gaa tgt tca tag                            321
Glu Lys Thr Val Ala Pro Thr Glu Cys Ser                                   
            100                 105                                       


<210>  45
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  45

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  46
<211>  354
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(354)
<223>  41D11-VH variable heavy chain (VH) sequence; 41D11: IgG1, lambda

<220>
<221>  V_region
<222>  (91)..(111)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (154)..(201)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (298)..(321)
<223>  complementarity determining region (CDR) VH-CDR3

<400>  46
cag gtg caa cta cat gag tcg ggc cca gga ctg gtg aag cct tcg gag         48
Gln Val Gln Leu His Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu           
1               5                   10                  15                

acc ctg tcc gta acc tgc agt ctc tct ggt ggc tcc atc agt agt agt         96
Thr Leu Ser Val Thr Cys Ser Leu Ser Gly Gly Ser Ile Ser Ser Ser           
            20                  25                  30                    

agt cac ctg tgg gcc tgg atc cgc cag ccc cca gag aag gga ctg gaa        144
Ser His Leu Trp Ala Trp Ile Arg Gln Pro Pro Glu Lys Gly Leu Glu           
        35                  40                  45                        

tat atc ggg cgt att cat tat agg ggc agt gtg tcc tac aat ccg tcc        192
Tyr Ile Gly Arg Ile His Tyr Arg Gly Ser Val Ser Tyr Asn Pro Ser           
    50                  55                  60                            

ctc aag agt cgc gcc gcc att tcc gtc gac acg gcc aag aac cag ttc        240
Leu Lys Ser Arg Ala Ala Ile Ser Val Asp Thr Ala Lys Asn Gln Phe           
65                  70                  75                  80            

tcc ctg acg ttg agt gct gtg acc gcc gca gac acg tct ttt tat tac        288
Ser Leu Thr Leu Ser Ala Val Thr Ala Ala Asp Thr Ser Phe Tyr Tyr           
                85                  90                  95                

tgt gcg aga ctg gac atg ggg gca ata gac aag tgg ggc cag gga acc        336
Cys Ala Arg Leu Asp Met Gly Ala Ile Asp Lys Trp Gly Gln Gly Thr           
            100                 105                 110                   

ctg gtc atc gtc tcc tca                                                354
Leu Val Ile Val Ser Ser                                                   
        115                                                               


<210>  47
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  47

Gln Val Gln Leu His Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Val Thr Cys Ser Leu Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Ser His Leu Trp Ala Trp Ile Arg Gln Pro Pro Glu Lys Gly Leu Glu 
        35                  40                  45              


Tyr Ile Gly Arg Ile His Tyr Arg Gly Ser Val Ser Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Ala Ala Ile Ser Val Asp Thr Ala Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Thr Leu Ser Ala Val Thr Ala Ala Asp Thr Ser Phe Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Leu Asp Met Gly Ala Ile Asp Lys Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Ile Val Ser Ser 
        115             


<210>  48
<211>  333
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(333)
<223>  41D11-VL variable light chain (VL) sequence, lambda type

<220>
<221>  V_region
<222>  (67)..(102)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (148)..(180)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (277)..(303)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  48
cag cct gtg ctg act caa tcg ccc tct gcc tct gcc tcc ctg gga gcc         48
Gln Pro Val Leu Thr Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala           
1               5                   10                  15                

tcg atc aaa ctc acc tgc act ctg agc agt gga cac agc aac tac gac         96
Ser Ile Lys Leu Thr Cys Thr Leu Ser Ser Gly His Ser Asn Tyr Asp           
            20                  25                  30                    

atc gct tgg cat caa cag cag tcg ggg aag ggc cct cga ttc ttg atg        144
Ile Ala Trp His Gln Gln Gln Ser Gly Lys Gly Pro Arg Phe Leu Met           
        35                  40                  45                        

aga gtt aac aat ggt gga agc cac aac aag ggg gac ggg atc cct gat        192
Arg Val Asn Asn Gly Gly Ser His Asn Lys Gly Asp Gly Ile Pro Asp           
    50                  55                  60                            

cgt ttc tca ggc tcc agc tct ggg gca gag cgc tac ctc aca atc tcc        240
Arg Phe Ser Gly Ser Ser Ser Gly Ala Glu Arg Tyr Leu Thr Ile Ser           
65                  70                  75                  80            

agt ctc cag tct gag gat gag gct gac tat tat tgt cag aca tgg ggc        288
Ser Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Thr Trp Gly           
                85                  90                  95                

act ggc act cat gtc ttc ggc act ggg act aag gtc acc gtc ctg            333
Thr Gly Thr His Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu               
            100                 105                 110                   


<210>  49
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  49

Gln Pro Val Leu Thr Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala 
1               5                   10                  15      


Ser Ile Lys Leu Thr Cys Thr Leu Ser Ser Gly His Ser Asn Tyr Asp 
            20                  25                  30          


Ile Ala Trp His Gln Gln Gln Ser Gly Lys Gly Pro Arg Phe Leu Met 
        35                  40                  45              


Arg Val Asn Asn Gly Gly Ser His Asn Lys Gly Asp Gly Ile Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Glu Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Thr Trp Gly 
                85                  90                  95      


Thr Gly Thr His Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210>  50
<211>  993
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(990)
<223>  41D11-CH constant heavy chain (CH) sequence

<220>
<221>  variation
<222>  (877)..(879)
<223>  ttc may be also ctc, thus Phe may be also Leu at position 293 of 
       the amino acid sequence

<400>  50
gcc tcc acc aag ggc cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag         48
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys           
1               5                   10                  15                

agc acc tct ggg ggc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac         96
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr           
            20                  25                  30                    

ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gcc ctg acc agc        144
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser           
        35                  40                  45                        

ggc gtg cac acc ttc ccg gct gtc cta cag tcc tca gga ctc tac tcc        192
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser           
    50                  55                  60                            

ctc agc agc gtg gtg acc gtg ccc tcc agc agc ttg ggc acc cag acc        240
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr           
65                  70                  75                  80            

tac atc tgc aac gtg aat cac aag ccc agc aac acc aag gtg gac aag        288
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys           
                85                  90                  95                

aga gtt gag ccc aaa tct tgt gac aaa act cac aca tgc cca ccg tgc        336
Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys           
            100                 105                 110                   

cca gca cct gaa ctc ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca        384
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro           
        115                 120                 125                       

aaa ccc aag gac acc ctc atg atc tcc cgg acc cct gag gtc aca tgc        432
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys           
    130                 135                 140                           

gtg gtg gtg gac gtg agc cac gaa gac cct gag gtc aag ttc aac tgg        480
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp           
145                 150                 155                 160           

tac gtg gac ggc gtg gag gtg cat aat gcc aag aca aag ccg cgg gag        528
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu           
                165                 170                 175               

gag cag tac aac agc acg tac cgt gtg gtc agc gtc ctc acc gtc ctg        576
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu           
            180                 185                 190                   

cac cag gac tgg ctg aat ggc aag gag tac aag tgc aag gtc tcc aac        624
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn           
        195                 200                 205                       

aaa gcc ctc cca gcc ccc atc gag aaa acc atc tcc aaa gcc aaa ggg        672
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly           
    210                 215                 220                           

cag ccc cga gaa cca cag gtg tac acc ctg ccc cca tcc cgg gag gag        720
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu           
225                 230                 235                 240           

atg acc aag aac cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat        768
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr           
                245                 250                 255               

ccc agc gac atc gcc gtg gag tgg gag agc aat ggg cag ccg gag aac        816
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn           
            260                 265                 270                   

aac tac aag acc acg cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc        864
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe           
        275                 280                 285                       

ctc tat agc aag ttc acc gtg gac aag agc agg tgg cag cag ggg aac        912
Leu Tyr Ser Lys Phe Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn           
    290                 295                 300                           

gtc ttc tca tgc tcc gtg atg cat gag gct ctg cac aac cac tac acg        960
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr           
305                 310                 315                 320           

cag aag agc ctc tcc ctg tcc ccg ggt aaa tga                            993
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys                                   
                325                 330                                   


<210>  51
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  51

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Phe Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  52
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(318)
<223>  41D11-CL constant lambda chain (CL) sequence

<220>
<221>  misc_feature
<222>  (250)..(321)
<223>  not sequenced but obtained from database

<400>  52
ggt cag ccc aag gcc aac ccc act gtc act ctg ttc ccg ccc tcc tct         48
Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser           
1               5                   10                  15                

gag gag ctc caa gcc aac aag gcc aca cta gtg tgt ctg atc agt gac         96
Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp           
            20                  25                  30                    

ttc tac ccg gga gct gtg aca gtg gcc tgg aag gca gat ggc agc ccc        144
Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro           
        35                  40                  45                        

gtc aag gcg gga gtg gag acc acc aaa ccc tcc aaa cag agc aac aac        192
Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn           
    50                  55                  60                            

aag tac gcg gcc agc agc tac ctg agc ctg acg ccc gag cag tgg aag        240
Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys           
65                  70                  75                  80            

tcc cac aga agc tac agc tgc cag gtc acg cat gaa ggg agc acc gtg        288
Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val           
                85                  90                  95                

gag aag aca gtg gcc cct aca gaa tgt tca tag                            321
Glu Lys Thr Val Ala Pro Thr Glu Cys Ser                                   
            100                 105                                       


<210>  53
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  53

Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  54
<211>  357
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(357)
<223>  51G4-VH-variable heavy chain (VH) sequence; 51G4: IgG2, lambda

<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  not sequenced but derived from primer used for molecular cloning

<220>
<221>  V_region
<222>  (91)..(105)
<223>  complementarity determining region (CDR) VH-CDR1

<220>
<221>  V_region
<222>  (148)..(198)
<223>  complementarity determining region (CDR) VH-CDR2

<220>
<221>  V_region
<222>  (295)..(324)
<223>  complementarity determining region (CDR) VH-CDR3

<220>
<221>  misc_feature
<222>  (340)..(357)
<223>  not sequenced but derived from primer used for molecular cloning

<400>  54
gag gtg cag ctg gtg cag tct ggg gct gag gtg aag aag cct ggg gcc         48
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag gtt tca tgt aaa act tct gga tac aaa ttc gct ctc tat         96
Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Lys Phe Ala Leu Tyr           
            20                  25                  30                    

gat att cat tgg gtg cgc cag gcc ccc gga caa ggg ctt gag tgg atg        144
Asp Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met           
        35                  40                  45                        

ggc tgg atc aac gct gcc aat ggt gac aca gaa tat tca cag aag ttt        192
Gly Trp Ile Asn Ala Ala Asn Gly Asp Thr Glu Tyr Ser Gln Lys Phe           
    50                  55                  60                            

gag ggc aga gtc acc att acc agg gac aca tcg gcg act aca gtc tac        240
Glu Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Thr Thr Val Tyr           
65                  70                  75                  80            

atg gag ttg aac agt ctg aca tat ggc gac acg gcc gtg tac tac tgt        288
Met Glu Leu Asn Ser Leu Thr Tyr Gly Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aga gag gaa ggt ctc tac aac tgg ttc gac ccc tgg ggc cag gga        336
Ala Arg Glu Glu Gly Leu Tyr Asn Trp Phe Asp Pro Trp Gly Gln Gly           
            100                 105                 110                   

acc ctg gtc acc gtc tcc tca                                            357
Thr Leu Val Thr Val Ser Ser                                               
        115                                                               


<210>  55
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  55

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Lys Phe Ala Leu Tyr 
            20                  25                  30          


Asp Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Ala Ala Asn Gly Asp Thr Glu Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Glu Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Thr Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Thr Tyr Gly Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Glu Gly Leu Tyr Asn Trp Phe Asp Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  56
<211>  327
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(327)
<223>  51G4-variable light chain (VL) sequence, lambda type

<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  not sequenced but derived from primer used for molecular cloning

<220>
<221>  V_region
<222>  (67)..(99)
<223>  complementarity determining region (CDR) VL-CDR1

<220>
<221>  V_region
<222>  (145)..(165)
<223>  complementarity determining region (CDR) VL-CDR2

<220>
<221>  V_region
<222>  (262)..(297)
<223>  complementarity determining region (CDR) VL-CDR3

<400>  56
tcc tat gag ctg aca cag gac cct gct gtg tct gtg gcc ttg gga cag         48
Ser Tyr Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln           
1               5                   10                  15                

aca gtc agg atc aca tgc caa gga gac agc ctc aga atc tat tat gca         96
Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ile Tyr Tyr Ala           
            20                  25                  30                    

aac tgg tac cag cag aag cca gga cag gcc cct gtt ctt gtc atc tat        144
Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr           
        35                  40                  45                        

ggt aaa agc aac cgg ccc tca ggg atc cca gac cga ttc tct gcc tcc        192
Gly Lys Ser Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Ala Ser           
    50                  55                  60                            

agc tca gga aac aca gct tcc ttg acc atc act ggg gct cag gcg gaa        240
Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu           
65                  70                  75                  80            

gat gag gct gac tat tac tgt aac tcc cgg gac agc agt gat aag cat        288
Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Asp Lys His           
                85                  90                  95                

ccc gtg cct ttc ggc ggg ggg acc aag ctg acc gtc cta                    327
Pro Val Pro Phe Gly Gly Gly Thr Lys Leu Thr Val Leu                       
            100                 105                                       


<210>  57
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  57

Ser Tyr Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ile Tyr Tyr Ala 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Ser Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Ala Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Asp Lys His 
                85                  90                  95      


Pro Val Pro Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  58
<211>  981
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(978)
<223>  51G4-CH constant heavy chain (CH) sequence

<220>
<221>  misc_feature
<222>  (1)..(47)
<223>  not sequenced but obtained from database

<400>  58
gcc tcc acc aag ggc cca tcg gtc ttc ccc ctg gcg ccc tgc tcc agg         48
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg           
1               5                   10                  15                

agc acc tcc gag agc aca gcg gcc ctg ggc tgc ctg gtc aag gac tac         96
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr           
            20                  25                  30                    

ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggt gct ctg acc agc        144
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser           
        35                  40                  45                        

ggc gtg cac acc ttc cca gct gtc cta cag tcc tca gga ctc tac tcc        192
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser           
    50                  55                  60                            

ctc agc agc gtg gtg acc gtg ccc tcc agc aac ttc ggc acc cag acc        240
Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr           
65                  70                  75                  80            

tac acc tgc aac gta gat cac aag ccc agc aac acc aag gtg gac aag        288
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys           
                85                  90                  95                

aca gtt gag cgc aaa tgt tgt gtc gag tgc cca ccg tgc cca gca cca        336
Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro           
            100                 105                 110                   

cct gtg gca gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac        384
Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp           
        115                 120                 125                       

acc ctc atg atc tcc cgg acc cct gag gtc acg tgc gtg gtg gtg gac        432
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp           
    130                 135                 140                           

gtg agc cac gaa gac ccc gag gtc cag ttc aac tgg tac gtg gac ggc        480
Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly           
145                 150                 155                 160           

gtg gag gtg cat aat gcc aag aca aag cca cgg gag gag cag ttc aac        528
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn           
                165                 170                 175               

agc acg ttc cgt gtg gtc agc gtc ctc acc gtt gtg cac cag gac tgg        576
Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp           
            180                 185                 190                   

ctg aac ggc aag gag tac aag tgc aag gtc tcc aac aaa ggc ctc cca        624
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro           
        195                 200                 205                       

gcc ccc atc gag aaa acc atc tcc aaa acc aaa ggg cag ccc cga gaa        672
Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu           
    210                 215                 220                           

cca cag gtg tac acc ctg ccc cca tcc cgg gag gag atg acc aag aac        720
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn           
225                 230                 235                 240           

cag gtc agc ctg acc tgc ctg gtc aaa ggc ttc tac ccc agc gac atc        768
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile           
                245                 250                 255               

gcc gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac aag acc        816
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr           
            260                 265                 270                   

aca cct ccc atg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag        864
Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys           
        275                 280                 285                       

ctc acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc        912
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys           
    290                 295                 300                           

tcc gtg atg cat gag gct ctg cac aac cac tac acg cag aag agc ctc        960
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu           
305                 310                 315                 320           

tcc ctg tct ccg ggt aaa tga                                            981
Ser Leu Ser Pro Gly Lys                                                   
                325                                                       


<210>  59
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  59

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  60
<211>  321
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(318)
<223>  51G4-CL constant lambda chain (CL) sequence

<220>
<221>  misc_feature
<222>  (27)..(321)
<223>  not sequenced but obtained from lambda constant chain of 24D3 
       from the same patient

<400>  60
agt cag ccc aag gct gcc ccc tcg gtc act ctg ttc ccg ccc tcc tct         48
Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser           
1               5                   10                  15                

gag gag ctt caa gcc aac aag gcc aca ctg gtg tgt ctc ata agt gac         96
Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp           
            20                  25                  30                    

ttc tac ccg gga gcc gtg aca gtg gcc tgg aag gca gat agc agc ccc        144
Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro           
        35                  40                  45                        

gtc aag gcg gga gtg gag acc acc aca ccc tcc aaa caa agc aac aac        192
Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn           
    50                  55                  60                            

aag tac gcg gcc agc agc tat ctg agc ctg acg cct gag cag tgg aag        240
Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys           
65                  70                  75                  80            

tcc cac aga agc tac agc tgc cag gtc acg cat gaa ggg agc acc gtg        288
Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val           
                85                  90                  95                

gag aag aca gtg gcc cct aca gaa tgt tca tag                            321
Glu Lys Thr Val Ala Pro Thr Glu Cys Ser                                   
            100                 105                                       


<210>  61
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  61

Ser Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  62
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward Oligonucleotide/Primer F1 for amplification of a fragment
       encoding aa 34-76 of IL-22

<400>  62
tttgggatcc tcgcgcccat cagctcccac tgca                                   34


<210>  63
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse Oligonucleotide/Primer R1 for amplification of a fragment
       encoding aa 34-76 of IL-22

<400>  63
tttgcggccg ctcacccaat gagacgaacg tctgt                                  35


<210>  64
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward oligonucleotide/primer F2 for amplification of a fragment
       encoding aa 74-114 of IL-22

<400>  64
tttgggatcc tcctcattgg ggagaaactg ttcc                                   34


<210>  65
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse oligonucleotide/primer R2 for amplification of a fragment
       encoding aa 74-114 of IL-22

<400>  65
tttgcggccg ctcaataagg ctggaaccta tcaga                                  35


<210>  66
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward oligonucleotide/primer F3 for amplification of a fragment
       encoding aa 113-179 of IL-22

<400>  66
tttgggatcc tcccttatat gcaggaggtg gt                                     32


<210>  67
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse oligonucleotide/primer R3 for amplification of a fragment
       encoding aa 113-179 of IL-22

<400>  67
tttgcggccg ctcaaatgca ggcatttctc aga                                    33


<210>  68
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward oligonucleotide/primer 34-114-F1 for amplification of a 
       fragment encoding aa 34-114 of IL-22

<400>  68
tttgggatcc tcgcgcccat cagctcccac tgca                                   34


<210>  69
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse oligonucleotide/primer 34-114-R2 for amplification of a 
       fragment encoding aa 34-114 of IL-22

<400>  69
tttgcggccg ctcaataagg ctggaaccta tcaga                                  35


<210>  70
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward oligonucleotide/primer 74-179-F2 for amplification of a 
       fragment encoding aa 74-179 of IL-22

<400>  70
tttgggatcc tcctcattgg ggagaaactg ttcc                                   34


<210>  71
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse oligonucleotide/primer 74-179-R3 for amplification of a 
       fragment encoding aa 74-179 of IL-22

<400>  71
tttgcggccg ctcaaatgca ggcatttctc aga                                    33


<210>  72
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward oligonucleotide/primer F1 for amplification of a fragment
       encoding aa 24-69 of IFN-alpha2a

<400>  72
tttgggatcc tctgtgatct gcctcaaacc caca                                   34


<210>  73
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse oligonucleotide/primer R1 for amplification of a fragment
       encoding aa 24-69 of IFN-alpha2a

<400>  73
tttgcggccg ctcactggtt gccaaactcc tcctg                                  35


<210>  74
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward oligonucleotide/primer F2 for amplification of a fragment
       encoding aa 67-124 of IFN-alpha2a

<400>  74
tttgggatcc tcggcaacca gttccaaaag gct                                    33


<210>  75
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse oligonucleotide/primer R2 for amplification of a fragment
       encoding aa 67-124 of IFN-alpha2a

<400>  75
tttgcggccg ctcactgtat cacacaggct tccag                                  35


<210>  76
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward oligonucleotide/primer F3 for amplification of a fragment
       encoding aa 123-188 of IFN-alpha2a

<400>  76
tttgggatcc tcatacaggg ggtgggggtg aca                                    33


<210>  77
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse oligonucleotide/primer R3 for amplification of a fragment
       encoding aa 123-188 of IFN-alpha2a

<400>  77
tttgcggccg cttacttctt aaactttctt gca                                    33


<210>  78
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward oligonucleotide/primer 24-124-F1 for amplification of a 
       fragment encoding aa 24-124 of IFN-alpha2a

<400>  78
tttgggatcc tctgtgatct gcctcaaacc caca                                   34


<210>  79
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse oligonucleotide/primer 24-124-R2 for amplification of a 
       fragment encoding aa 24-124 of IFN-alpha2a

<400>  79
tttgcggccg ctcactgtat cacacaggct tccag                                  35


<210>  80
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward oligonucleotide/primer 67-188-F2 for amplification of a 
       fragment encoding aa 67-188 of IFN-alpha2a

<400>  80
tttgggatcc tcggcaacca gttccaaaag gct                                    33


<210>  81
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward oligonucleotide/primer 67-188-F3 for amplification of a 
       fragment encoding aa 67-188 of IFN-alpha2a

<400>  81
tttgcggccg cttacttctt aaactttctt gca                                    33


