                         SEQUENCE LISTING

<110>  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE 
       SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
 
<120>  METHODS OF TREATING OR PREVENTING VIRAL DISEASES BY BLOCKING 
       INTERLEUKIN-21

<130>  711840

<150>  US 61/579,801
<151>  2011-12-23

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  616
<212>  DNA
<213>  Homo sapiens

<400>  1
ctgaagtgaa aacgagacca aggtctagct ctactgttgg tacttatgag atccagtcct       60

ggcaacatgg agaggattgt catctgtctg atggtcatct tcttggggac actggtccac      120

aaatcaagct cccaaggtca agatcgccac atgattagaa tgcgtcaact tatagatatt      180

gttgatcagc tgaaaaatta tgtgaatgac ttggtccctg aatttctgcc agctccagaa      240

gatgtagaga caaactgtga gtggtcagct ttttcctgct ttcagaaggc ccaactaaag      300

tcagcaaata caggaaacaa tgaaaggata atcaatgtat caattaaaaa gctgaagagg      360

aaaccacctt ccacaaatgc agggagaaga cagaaacaca gactaacatg cccttcatgt      420

gattcttatg agaaaaaacc acccaaagaa ttcctagaaa gattcaaatc acttctccaa      480

aagatgattc atcagcatct gtcctctaga acacacggaa gtgaagattc ctgaggatct      540

aacttgcagt tggacactat gttacatact ctaatatagt agtgaaagtc atttctttgt      600

attccaagtg gaggag                                                      616


<210>  2
<211>  706
<212>  DNA
<213>  Homo sapiens

<400>  2
ctgaagtgaa aacgagacca aggtctagct ctactgttgg tacttatgag atccagtcct       60

ggcaacatgg agaggattgt catctgtctg atggtcatct tcttggggac actggtccac      120

aaatcaagct cccaaggtca agatcgccac atgattagaa tgcgtcaact tatagatatt      180

gttgatcagc tgaaaaatta tgtgaatgac ttggtccctg aatttctgcc agctccagaa      240

gatgtagaga caaactgtga gtggtcagct ttttcctgct ttcagaaggc ccaactaaag      300

tcagcaaata caggaaacaa tgaaaggata atcaatgtat caattaaaaa gctgaagagg      360

aaaccacctt ccacaaatgc agggagaaga cagaaacaca gactaacatg cccttcatgt      420

gattcttatg agaaaaaacc acccaaagaa ttcctagaaa gattcaaatc acttctccaa      480

aaggtatcta ccttaagttt catttgattt tctgctttat ctttacctat ccagatttgc      540

ttcttagtta ctcacggtat actatttcca cagatgattc atcagcatct gtcctctaga      600

acacacggaa gtgaagattc ctgaggatct aacttgcagt tggacactat gttacatact      660

ctaatatagt agtgaaagtc atttctttgt attccaagtg gaggag                     706


<210>  3
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Arg Ser Ser Pro Gly Asn Met Glu Arg Ile Val Ile Cys Leu Met 
1               5                   10                  15      


Val Ile Phe Leu Gly Thr Leu Val His Lys Ser Ser Ser Gln Gly Gln 
            20                  25                  30          


Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln 
        35                  40                  45              


Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro 
    50                  55                  60                  


Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln 
65                  70                  75                  80  


Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile 
                85                  90                  95      


Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala 
            100                 105                 110         


Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr 
        115                 120                 125             


Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu 
    130                 135                 140                 


Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu 
145                 150                 155                 160 


Asp Ser 
        


<210>  4
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Arg Ser Ser Pro Gly Asn Met Glu Arg Ile Val Ile Cys Leu Met 
1               5                   10                  15      


Val Ile Phe Leu Gly Thr Leu Val His Lys Ser Ser Ser Gln Gly Gln 
            20                  25                  30          


Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln 
        35                  40                  45              


Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro 
    50                  55                  60                  


Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln 
65                  70                  75                  80  


Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile 
                85                  90                  95      


Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala 
            100                 105                 110         


Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr 
        115                 120                 125             


Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu 
    130                 135                 140                 


Gln Lys Val Ser Thr Leu Ser Phe Ile 
145                 150             


<210>  5
<211>  3072
<212>  DNA
<213>  Mus musculus

<400>  5
gagaaccaga ccaaggccct gtcatcagct cctggagact cagttctggt ggcatggaga       60

ggacccttgt ctgtctggta gtcatcttct tggggacagt ggcccataaa tcaagccccc      120

aagggccaga tcgcctcctg attagacttc gtcaccttat tgacattgtt gaacagctga      180

aaatctatga aaatgacttg gatcctgaac ttctatcagc tccacaagat gtaaaggggc      240

actgtgagca tgcagctttt gcctgttttc agaaggccaa actcaagcca tcaaaccctg      300

gaaacaataa gacattcatc attgacctcg tggcccagct caggaggagg ctgcctgcca      360

ggaggggagg aaagaaacag aagcacatag ctaaatgccc ttcctgtgat tcgtatgaga      420

aaaggacacc caaagaattc ctagaaagac taaaatggct ccttcaaaag atgattcatc      480

agcatctctc ctagaacaca taggacccga agattcctga ggatccgaga agattcccga      540

ggactgagga gacgccggac actatagacg ctcacgaatg caggagtaca tcttgcctct      600

tgggattgca agtggagaag tacgatacgt tatgataaga acaactcaga aaagctatag      660

gttaagatcc tttcgcccat taactaagca gacattgtgg ttccctgcac agactccatg      720

ctgtcaacat ggaaaatctc aactcaacaa gagcccagct tcccgtgtca gggatttctg      780

gtgcttctca agctgtggct tcatcttatt gcccaactgt gacattcttt gattggaagg      840

ggaaaactaa agcttttagc aaaaatacag ctagggaatt tgtcgatctg cgagagtaag      900

acctcttatg atcctaacgg aatgatgtaa gctggaaata ataagcataa gatgaaattg      960

aaaattgaag tctttattct ttaagaaaaa ctttgtactt gaaagcatgt ctgaagagtt     1020

tactcattac cacaaacatc tagcatattg ataactaaca tctttatact ctacaagaga     1080

ggctttccag ataggtacag tttttcttct ctattaggtc tatcaaaatt taacctatta     1140

tgagggtcac ccctggcttt cactgttttt ctaaagaggc aagggtgtag taagaagcag     1200

gcttaagttg ccttcctccc aatgtcaagt tcctttataa gctaatagtt taatcttgtg     1260

aagatggcaa tgaaagcctg tggaagtgca aacctcacta tcttctggag ccaagtagaa     1320

ttttcaagtt tgtagctctc acctcaagtg gttatgggtg tcctgtgatg aatctgctag     1380

ctccagcctc agtctcctct cccacatcct ttcctttctt tcctctttga aacttctaag     1440

aaaaagcaat ccaaacaagt tcagcactta agacacattg catgcacact tttgataagt     1500

taaatccaac catctattta aaatcaaaat caggagatga gccaagagac cagaggttct     1560

gttccagttt taaacagact tttactgaac atcccaatct tttaaccaca gaggctaaat     1620

tgagcaaata gttttgccat ttgatataat ttccaacagt atgtttcaat gtcaagttaa     1680

aaagtctaca aagctatttt ccctggagtg gtatcatcgc tttgagaatt tcttatggtt     1740

aaaatggatc tgagatccaa gcatggcctg ggggatggtt ttgatctaag gaaaaaggtg     1800

tctgtacctc acagtgcctt taaaacaagc agagatcccg tgtaccgccc taagatagca     1860

cagactagtg ttaactgatt cccagaaaag tgtcacaatc agaaccaacg cattctctta     1920

aactttaaaa atatgtattg caaagaactt gtgtaactgt aaatgtgtga ctgttgatga     1980

cattatacac acatagccca cgtaagtgtc caatggtgct agcattggtt gctgagtttg     2040

ctgctcgaaa gctgaagcag agatgcagtc cttcacaaag caatgatgga cagagagggg     2100

agtctccatg ttttattctt ttgttgtttc tggctgtgta actgttgact tcttgacatt     2160

gtgattttta tatttaagac aatgtattta ttttggtgtg tttattgttc tagcctttta     2220

aatcactgac aatttctaat caagaagtac aaataattca atgcagcaca ggctaagagc     2280

ttgtatcgtt tggaaaagcc agtgaaggct tctccactag ccatgggaaa gctacgcttt     2340

agagtaaact agacaaaatt gcacagcagt cttgaacctc tctgtgctca agactcagcc     2400

agtcctttga cattattgtt cactgtgggt gggaacacat tggacctgac acactgttgt     2460

gtgtccatga aggttgccac tggtgtaagc tttttttggt tttcattctc ttatctgtag     2520

aacaagaatg tggggctttc ctaagtctat tctgtatttt attctgaact tcgtatgtct     2580

gagttttaat gttttgagta ctcttacagg aacacctgac cacacttttg agttaaattt     2640

tatcccaagt gtgatattta gttgttcaaa aagggaaggg atatacatac atacatacat     2700

acatacatac atatatatat atatatatac atatatatat atatatatat gtatatatat     2760

atatatatag agagagagag agagagagag agagaaagag agagaggttg ttgtaggtca     2820

taggagttca gaggaaatca gttatggccg ttaatactgt agctgaaagt gttttctttg     2880

tgaataaatt catagcatta ttgatctatg ttattgctct gttttattta cagtcacacc     2940

tgagaattta gttttaatat gaatgatgta ctttataact taatgattat ttattatgta     3000

tttggttttg aatgtttgtg ttcatggctt cttatttaag acctgatcat attaaatgct     3060

acccagtcag aa                                                         3072


<210>  6
<211>  146
<212>  PRT
<213>  Mus musculus

<400>  6

Met Glu Arg Thr Leu Val Cys Leu Val Val Ile Phe Leu Gly Thr Val 
1               5                   10                  15      


Ala His Lys Ser Ser Pro Gln Gly Pro Asp Arg Leu Leu Ile Arg Leu 
            20                  25                  30          


Arg His Leu Ile Asp Ile Val Glu Gln Leu Lys Ile Tyr Glu Asn Asp 
        35                  40                  45              


Leu Asp Pro Glu Leu Leu Ser Ala Pro Gln Asp Val Lys Gly His Cys 
    50                  55                  60                  


Glu His Ala Ala Phe Ala Cys Phe Gln Lys Ala Lys Leu Lys Pro Ser 
65                  70                  75                  80  


Asn Pro Gly Asn Asn Lys Thr Phe Ile Ile Asp Leu Val Ala Gln Leu 
                85                  90                  95      


Arg Arg Arg Leu Pro Ala Arg Arg Gly Gly Lys Lys Gln Lys His Ile 
            100                 105                 110         


Ala Lys Cys Pro Ser Cys Asp Ser Tyr Glu Lys Arg Thr Pro Lys Glu 
        115                 120                 125             


Phe Leu Glu Arg Leu Lys Trp Leu Leu Gln Lys Met Ile His Gln His 
    130                 135                 140                 


Leu Ser 
145     


<210>  7
<211>  4512
<212>  DNA
<213>  Homo sapiens

<400>  7
ctagaggcag ctcagataga ggagctcttt gggaagagac gccgggcagg cagaagcagc       60

aggtaccccc tccacatccc tagggctctg tgatgtaggc agaggcccgt gggagtcagc      120

atgccgcgtg gctgggccgc ccccttgctc ctgctgctgc tccagggagg ctggggctgc      180

cccgacctcg tctgctacac cgattacctc cagacggtca tctgcatcct ggaaatgtgg      240

aacctccacc ccagcacgct cacccttacc tggcaagacc agtatgaaga gctgaaggac      300

gaggccacct cctgcagcct ccacaggtcg gcccacaatg ccacgcatgc cacctacacc      360

tgccacatgg atgtattcca cttcatggcc gacgacattt tcagtgtcaa catcacagac      420

cagtctggca actactccca ggagtgtggc agctttctcc tggctgagag catcaagccg      480

gctccccctt tcaacgtgac tgtgaccttc tcaggacagt ataatatctc ctggcgctca      540

gattacgaag accctgcctt ctacatgctg aagggcaagc ttcagtatga gctgcagtac      600

aggaaccggg gagacccctg ggctgtgagt ccgaggagaa agctgatctc agtggactca      660

agaagtgtct ccctcctccc cctggagttc cgcaaagact cgagctatga gctgcaggtg      720

cgggcagggc ccatgcctgg ctcctcctac caggggacct ggagtgaatg gagtgacccg      780

gtcatctttc agacccagtc agaggagtta aaggaaggct ggaaccctca cctgctgctt      840

ctcctcctgc ttgtcatagt cttcattcct gccttctgga gcctgaagac ccatccattg      900

tggaggctat ggaagaagat atgggccgtc cccagccctg agcggttctt catgcccctg      960

tacaagggct gcagcggaga cttcaagaaa tgggtgggtg cacccttcac tggctccagc     1020

ctggagctgg gaccctggag cccagaggtg ccctccaccc tggaggtgta cagctgccac     1080

ccaccacgga gcccggccaa gaggctgcag ctcacggagc tacaagaacc agcagagctg     1140

gtggagtctg acggtgtgcc caagcccagc ttctggccga cagcccagaa ctcggggggc     1200

tcagcttaca gtgaggagag ggatcggcca tacggcctgg tgtccattga cacagtgact     1260

gtgctagatg cagaggggcc atgcacctgg ccctgcagct gtgaggatga cggctaccca     1320

gccctggacc tggatgctgg cctggagccc agcccaggcc tagaggaccc actcttggat     1380

gcagggacca cagtcctgtc ctgtggctgt gtctcagctg gcagccctgg gctaggaggg     1440

cccctgggaa gcctcctgga cagactaaag ccaccccttg cagatgggga ggactgggct     1500

gggggactgc cctggggtgg ccggtcacct ggaggggtct cagagagtga ggcgggctca     1560

cccctggccg gcctggatat ggacacgttt gacagtggct ttgtgggctc tgactgcagc     1620

agccctgtgg agtgtgactt caccagcccc ggggacgaag gacccccccg gagctacctc     1680

cgccagtggg tggtcattcc tccgccactt tcgagccctg gaccccaggc cagctaatga     1740

ggctgactgg atgtccagag ctggccaggc cactgggccc tgagccagag acaaggtcac     1800

ctgggctgtg atgtgaagac acctgcagcc tttggtctcc tggatgggcc tttgagcctg     1860

atgtttacag tgtctgtgtg tgtgtgtgca tatgtgtgtg tgtgcatatg catgtgtgtg     1920

tgtgtgtgtg tcttaggtgc gcagtggcat gtccacgtgt gtgtgtgatt gcacgtgcct     1980

gtgggcctgg gataatgccc atggtactcc atgcattcac ctgccctgtg catgtctgga     2040

ctcacggagc tcacccatgt gcacaagtgt gcacagtaaa cgtgtttgtg gtcaacagat     2100

gacaacagcc gtcctccctc ctagggtctt gtgttgcaag ttggtccaca gcatctccgg     2160

ggctttgtgg gatcagggca ttgcctgtga ctgaggcgga gcccagccct ccagcgtctg     2220

cctccaggag ctgcaagaag tccatattgt tccttatcac ctgccaacag gaagcgaaag     2280

gggatggagt gagcccatgg tgacctcggg aatggcaatt ttttgggcgg cccctggacg     2340

aaggtctgaa tcccgactct gataccttct ggctgtgcta cctgagccaa gtcgcctccc     2400

ctctctgggc tagagtttcc ttatccagac agtggggaag gcatgacaca cctgggggaa     2460

attggcgatg tcacccgtgt acggtacgca gcccagagca gaccctcaat aaacgtcagc     2520

ttccttcctt ctgcggccag agccgaggcg ggcgggggtg agaacatcaa tcgtcagcga     2580

cagcctgggc acccgcgggg ccgtcccgcc tgcagagggc cactcggggg ggtttccagg     2640

cttaaaatca gtccgtttcg tctcttggaa acagctcccc accaaccaag atttcttttt     2700

ctaacttctg ctactaagtt tttaaaaatt ccctttatgc acccaagaga tatttattaa     2760

acaccaatta cgtagcaggc catggctcat gggacccacc ccccgtggca ctcatggagg     2820

gggctgcagg ttggaactat gcagtgtgct ccggccacac atcctgctgg gccccctacc     2880

ctgccccaat tcaatcctgc caataaatcc tgtcttattt gttcatcctg gagaattgaa     2940

gggaggtcaa gttgtttgtc aatgatttgt cagagaacct gttgaaatgt gaattaagaa     3000

gctaagaaaa tatttcttag caacattttc tttttctttt tttttttttt cttttgagac     3060

agagtctcac tctcgtcgcc caggctggaa tgcagtggtg cgatctcggc tctctgcaac     3120

ctctgtctcc cgggttcaag cgatttcctg cgtcagcccc agagtagctg gaattacagg     3180

cacacaccac cacgcctggc taatttttgt atttttagta gagctggggc caccctggcc     3240

cggccccgtc ttcctcccca aaggtcagac tgcaggctgc agggctgtgc tggaggagcc     3300

agctctagct cacccatgct tttgcaacag ggtcgggttg gaagtcagca caggtcagtc     3360

ctgcggaagg ttccttcgtg actcatctgt gaagtggggt ggttgggaga ggtagctgag     3420

agaatgcatg agagtcctcg gtgcctggca ggaggctgga aggttctaga acactgatgg     3480

ttataagagt gggactgtga gcctgggatc ggggggtgtg agacttggat gggagcacaa     3540

gagtggaaac acagcttctg cacggagcag gcgcagccct caacaccccg tgcacctgca     3600

ccctagggac tcttgggtcc agatgtgctg tggttttcac accttcttgg gggcaacagg     3660

ttccaggagc cacctgtggg tgccacctga gccacaggct cccaggaaag cagcacagct     3720

ctcctgcacc cagagcttgc tgggtggcgg aggggaacac agatggttgg ggaaggcctg     3780

aggccagatt gggggactct ggactggggc agatgaggct cctcagaatc ccacctttga     3840

agggaactca gcttataaac acagaggagc aaagttggag ggccgggcgt agtggctcac     3900

acctgtgatc tcagcacttt gggaggccaa ggaaggtgga tcacttgagg ccaggagttc     3960

gagaccagcc tgggcaacat agcaaggccc catctctaca aaaattatta ttttttaaaa     4020

aaattagcca ggtgtggtgg tgcttgccta tagtcccagc tactcgggag gctaaggtgg     4080

gaggatcgct ggagcccagg aatttgaggc tgcagtgagc tgtgattaca ccgttgcact     4140

ccagcctggg tcacagatca agaccctgtc tcttaaaaat aaaagttgga gacaagagct     4200

ggctcacctg aaaggaggga ttagtaggta ggagggtgga tggaggatgg atggatgtgt     4260

gggtggatag gaagatggta ttaagttggt gcaaaagtct ttgatattac tcttaatggc     4320

tttaataaaa agcttgaagg aagaatgatt ggttggatag acagagataa atgcatactg     4380

gaaacaaaga taaagataaa acacaagtta taccaggcca gcaactctat tttgttcact     4440

gcctttagtc ccagcctggc acatagtagg cactcaataa agcctgattt gtagcaaaaa     4500

aaaaaaaaaa aa                                                         4512


<210>  8
<211>  4865
<212>  DNA
<213>  Homo sapiens

<400>  8
ctcttcctcc ccactctgca catgcggctg ggtggcagcc agcggcctca gacagaccca       60

ctggcgtctc tctgctgagt gaccgtaagc tcggcgtctg gccctctgcc tgcctctccc      120

tgagtgtggc tgacagccac gcagctgtgt ctgtctgtct gcggcccgtg catccctgct      180

gcggccgcct ggtaccttcc ttgccgtctc tttcctctgt ctgctgctct gtgggacacc      240

tgcctggagg cccagctgcc cgtcatcaga gtgacaggtc ttatgacagc ctgattggtg      300

actcgggctg ggtgtggatt ctcaccccag gcctctgcct gctttctcag accctcatct      360

gtcaccccca cgctgaaccc agctgccacc cccagaagcc catcagactg cccccagcac      420

acggaatgga tttctgagaa agaagccgaa acagaaggcc cgtgggagtc agcatgccgc      480

gtggctgggc cgcccccttg ctcctgctgc tgctccaggg aggctggggc tgccccgacc      540

tcgtctgcta caccgattac ctccagacgg tcatctgcat cctggaaatg tggaacctcc      600

accccagcac gctcaccctt acctggcaag accagtatga agagctgaag gacgaggcca      660

cctcctgcag cctccacagg tcggcccaca atgccacgca tgccacctac acctgccaca      720

tggatgtatt ccacttcatg gccgacgaca ttttcagtgt caacatcaca gaccagtctg      780

gcaactactc ccaggagtgt ggcagctttc tcctggctga gagcatcaag ccggctcccc      840

ctttcaacgt gactgtgacc ttctcaggac agtataatat ctcctggcgc tcagattacg      900

aagaccctgc cttctacatg ctgaagggca agcttcagta tgagctgcag tacaggaacc      960

ggggagaccc ctgggctgtg agtccgagga gaaagctgat ctcagtggac tcaagaagtg     1020

tctccctcct ccccctggag ttccgcaaag actcgagcta tgagctgcag gtgcgggcag     1080

ggcccatgcc tggctcctcc taccagggga cctggagtga atggagtgac ccggtcatct     1140

ttcagaccca gtcagaggag ttaaaggaag gctggaaccc tcacctgctg cttctcctcc     1200

tgcttgtcat agtcttcatt cctgccttct ggagcctgaa gacccatcca ttgtggaggc     1260

tatggaagaa gatatgggcc gtccccagcc ctgagcggtt cttcatgccc ctgtacaagg     1320

gctgcagcgg agacttcaag aaatgggtgg gtgcaccctt cactggctcc agcctggagc     1380

tgggaccctg gagcccagag gtgccctcca ccctggaggt gtacagctgc cacccaccac     1440

ggagcccggc caagaggctg cagctcacgg agctacaaga accagcagag ctggtggagt     1500

ctgacggtgt gcccaagccc agcttctggc cgacagccca gaactcgggg ggctcagctt     1560

acagtgagga gagggatcgg ccatacggcc tggtgtccat tgacacagtg actgtgctag     1620

atgcagaggg gccatgcacc tggccctgca gctgtgagga tgacggctac ccagccctgg     1680

acctggatgc tggcctggag cccagcccag gcctagagga cccactcttg gatgcaggga     1740

ccacagtcct gtcctgtggc tgtgtctcag ctggcagccc tgggctagga gggcccctgg     1800

gaagcctcct ggacagacta aagccacccc ttgcagatgg ggaggactgg gctgggggac     1860

tgccctgggg tggccggtca cctggagggg tctcagagag tgaggcgggc tcacccctgg     1920

ccggcctgga tatggacacg tttgacagtg gctttgtggg ctctgactgc agcagccctg     1980

tggagtgtga cttcaccagc cccggggacg aaggaccccc ccggagctac ctccgccagt     2040

gggtggtcat tcctccgcca ctttcgagcc ctggacccca ggccagctaa tgaggctgac     2100

tggatgtcca gagctggcca ggccactggg ccctgagcca gagacaaggt cacctgggct     2160

gtgatgtgaa gacacctgca gcctttggtc tcctggatgg gcctttgagc ctgatgttta     2220

cagtgtctgt gtgtgtgtgt gcatatgtgt gtgtgtgcat atgcatgtgt gtgtgtgtgt     2280

gtgtcttagg tgcgcagtgg catgtccacg tgtgtgtgtg attgcacgtg cctgtgggcc     2340

tgggataatg cccatggtac tccatgcatt cacctgccct gtgcatgtct ggactcacgg     2400

agctcaccca tgtgcacaag tgtgcacagt aaacgtgttt gtggtcaaca gatgacaaca     2460

gccgtcctcc ctcctagggt cttgtgttgc aagttggtcc acagcatctc cggggctttg     2520

tgggatcagg gcattgcctg tgactgaggc ggagcccagc cctccagcgt ctgcctccag     2580

gagctgcaag aagtccatat tgttccttat cacctgccaa caggaagcga aaggggatgg     2640

agtgagccca tggtgacctc gggaatggca attttttggg cggcccctgg acgaaggtct     2700

gaatcccgac tctgatacct tctggctgtg ctacctgagc caagtcgcct cccctctctg     2760

ggctagagtt tccttatcca gacagtgggg aaggcatgac acacctgggg gaaattggcg     2820

atgtcacccg tgtacggtac gcagcccaga gcagaccctc aataaacgtc agcttccttc     2880

cttctgcggc cagagccgag gcgggcgggg gtgagaacat caatcgtcag cgacagcctg     2940

ggcacccgcg gggccgtccc gcctgcagag ggccactcgg gggggtttcc aggcttaaaa     3000

tcagtccgtt tcgtctcttg gaaacagctc cccaccaacc aagatttctt tttctaactt     3060

ctgctactaa gtttttaaaa attcccttta tgcacccaag agatatttat taaacaccaa     3120

ttacgtagca ggccatggct catgggaccc accccccgtg gcactcatgg agggggctgc     3180

aggttggaac tatgcagtgt gctccggcca cacatcctgc tgggccccct accctgcccc     3240

aattcaatcc tgccaataaa tcctgtctta tttgttcatc ctggagaatt gaagggaggt     3300

caagttgttt gtcaatgatt tgtcagagaa cctgttgaaa tgtgaattaa gaagctaaga     3360

aaatatttct tagcaacatt ttctttttct tttttttttt tttcttttga gacagagtct     3420

cactctcgtc gcccaggctg gaatgcagtg gtgcgatctc ggctctctgc aacctctgtc     3480

tcccgggttc aagcgatttc ctgcgtcagc cccagagtag ctggaattac aggcacacac     3540

caccacgcct ggctaatttt tgtattttta gtagagctgg ggccaccctg gcccggcccc     3600

gtcttcctcc ccaaaggtca gactgcaggc tgcagggctg tgctggagga gccagctcta     3660

gctcacccat gcttttgcaa cagggtcggg ttggaagtca gcacaggtca gtcctgcgga     3720

aggttccttc gtgactcatc tgtgaagtgg ggtggttggg agaggtagct gagagaatgc     3780

atgagagtcc tcggtgcctg gcaggaggct ggaaggttct agaacactga tggttataag     3840

agtgggactg tgagcctggg atcggggggt gtgagacttg gatgggagca caagagtgga     3900

aacacagctt ctgcacggag caggcgcagc cctcaacacc ccgtgcacct gcaccctagg     3960

gactcttggg tccagatgtg ctgtggtttt cacaccttct tgggggcaac aggttccagg     4020

agccacctgt gggtgccacc tgagccacag gctcccagga aagcagcaca gctctcctgc     4080

acccagagct tgctgggtgg cggaggggaa cacagatggt tggggaaggc ctgaggccag     4140

attgggggac tctggactgg ggcagatgag gctcctcaga atcccacctt tgaagggaac     4200

tcagcttata aacacagagg agcaaagttg gagggccggg cgtagtggct cacacctgtg     4260

atctcagcac tttgggaggc caaggaaggt ggatcacttg aggccaggag ttcgagacca     4320

gcctgggcaa catagcaagg ccccatctct acaaaaatta ttatttttta aaaaaattag     4380

ccaggtgtgg tggtgcttgc ctatagtccc agctactcgg gaggctaagg tgggaggatc     4440

gctggagccc aggaatttga ggctgcagtg agctgtgatt acaccgttgc actccagcct     4500

gggtcacaga tcaagaccct gtctcttaaa aataaaagtt ggagacaaga gctggctcac     4560

ctgaaaggag ggattagtag gtaggagggt ggatggagga tggatggatg tgtgggtgga     4620

taggaagatg gtattaagtt ggtgcaaaag tctttgatat tactcttaat ggctttaata     4680

aaaagcttga aggaagaatg attggttgga tagacagaga taaatgcata ctggaaacaa     4740

agataaagat aaaacacaag ttataccagg ccagcaactc tattttgttc actgccttta     4800

gtcccagcct ggcacatagt aggcactcaa taaagcctga tttgtagcaa aaaaaaaaaa     4860

aaaaa                                                                 4865


<210>  9
<211>  5006
<212>  DNA
<213>  Homo sapiens

<400>  9
ctcttcctcc ccactctgca catgcggctg ggtggcagcc agcggcctca gacagaccca       60

ctggcgtctc tctgctgagt gaccgtaagc tcggcgtctg gccctctgcc tgcctctccc      120

tgagtgtggc tgacagccac gcagctgtgt ctgtctgtct gcggcccgtg catccctgct      180

gcggccgcct ggtaccttcc ttgccgtctc tttcctctgt ctgctgctct gtgggacacc      240

tgcctggagg cccagctgcc cgtcatcaga gtgacaggtc ttatgacagc ctgattggtg      300

actcgggctg ggtgtggatt ctcaccccag gcctctgcct gctttctcag accctcatct      360

gtcaccccca cgctgaaccc agctgccacc cccagaagcc catcagactg cccccagcac      420

acggaatgga tttctgagaa agaagccgaa acagaagatg aggcaatgag gctgcgagag      480

gtagagtgat tttccctcgg tgactcaact gggacgtagc aggtcgggca gtcaagccag      540

gtgaccccat gagctgtcgc tgcatctttc tcatgaagca cggggaacgg gtcggatggc      600

ccgtgggagt cagcatgccg cgtggctggg ccgccccctt gctcctgctg ctgctccagg      660

gaggctgggg ctgccccgac ctcgtctgct acaccgatta cctccagacg gtcatctgca      720

tcctggaaat gtggaacctc caccccagca cgctcaccct tacctggcaa gaccagtatg      780

aagagctgaa ggacgaggcc acctcctgca gcctccacag gtcggcccac aatgccacgc      840

atgccaccta cacctgccac atggatgtat tccacttcat ggccgacgac attttcagtg      900

tcaacatcac agaccagtct ggcaactact cccaggagtg tggcagcttt ctcctggctg      960

agagcatcaa gccggctccc cctttcaacg tgactgtgac cttctcagga cagtataata     1020

tctcctggcg ctcagattac gaagaccctg ccttctacat gctgaagggc aagcttcagt     1080

atgagctgca gtacaggaac cggggagacc cctgggctgt gagtccgagg agaaagctga     1140

tctcagtgga ctcaagaagt gtctccctcc tccccctgga gttccgcaaa gactcgagct     1200

atgagctgca ggtgcgggca gggcccatgc ctggctcctc ctaccagggg acctggagtg     1260

aatggagtga cccggtcatc tttcagaccc agtcagagga gttaaaggaa ggctggaacc     1320

ctcacctgct gcttctcctc ctgcttgtca tagtcttcat tcctgccttc tggagcctga     1380

agacccatcc attgtggagg ctatggaaga agatatgggc cgtccccagc cctgagcggt     1440

tcttcatgcc cctgtacaag ggctgcagcg gagacttcaa gaaatgggtg ggtgcaccct     1500

tcactggctc cagcctggag ctgggaccct ggagcccaga ggtgccctcc accctggagg     1560

tgtacagctg ccacccacca cggagcccgg ccaagaggct gcagctcacg gagctacaag     1620

aaccagcaga gctggtggag tctgacggtg tgcccaagcc cagcttctgg ccgacagccc     1680

agaactcggg gggctcagct tacagtgagg agagggatcg gccatacggc ctggtgtcca     1740

ttgacacagt gactgtgcta gatgcagagg ggccatgcac ctggccctgc agctgtgagg     1800

atgacggcta cccagccctg gacctggatg ctggcctgga gcccagccca ggcctagagg     1860

acccactctt ggatgcaggg accacagtcc tgtcctgtgg ctgtgtctca gctggcagcc     1920

ctgggctagg agggcccctg ggaagcctcc tggacagact aaagccaccc cttgcagatg     1980

gggaggactg ggctggggga ctgccctggg gtggccggtc acctggaggg gtctcagaga     2040

gtgaggcggg ctcacccctg gccggcctgg atatggacac gtttgacagt ggctttgtgg     2100

gctctgactg cagcagccct gtggagtgtg acttcaccag ccccggggac gaaggacccc     2160

cccggagcta cctccgccag tgggtggtca ttcctccgcc actttcgagc cctggacccc     2220

aggccagcta atgaggctga ctggatgtcc agagctggcc aggccactgg gccctgagcc     2280

agagacaagg tcacctgggc tgtgatgtga agacacctgc agcctttggt ctcctggatg     2340

ggcctttgag cctgatgttt acagtgtctg tgtgtgtgtg tgcatatgtg tgtgtgtgca     2400

tatgcatgtg tgtgtgtgtg tgtgtcttag gtgcgcagtg gcatgtccac gtgtgtgtgt     2460

gattgcacgt gcctgtgggc ctgggataat gcccatggta ctccatgcat tcacctgccc     2520

tgtgcatgtc tggactcacg gagctcaccc atgtgcacaa gtgtgcacag taaacgtgtt     2580

tgtggtcaac agatgacaac agccgtcctc cctcctaggg tcttgtgttg caagttggtc     2640

cacagcatct ccggggcttt gtgggatcag ggcattgcct gtgactgagg cggagcccag     2700

ccctccagcg tctgcctcca ggagctgcaa gaagtccata ttgttcctta tcacctgcca     2760

acaggaagcg aaaggggatg gagtgagccc atggtgacct cgggaatggc aattttttgg     2820

gcggcccctg gacgaaggtc tgaatcccga ctctgatacc ttctggctgt gctacctgag     2880

ccaagtcgcc tcccctctct gggctagagt ttccttatcc agacagtggg gaaggcatga     2940

cacacctggg ggaaattggc gatgtcaccc gtgtacggta cgcagcccag agcagaccct     3000

caataaacgt cagcttcctt ccttctgcgg ccagagccga ggcgggcggg ggtgagaaca     3060

tcaatcgtca gcgacagcct gggcacccgc ggggccgtcc cgcctgcaga gggccactcg     3120

ggggggtttc caggcttaaa atcagtccgt ttcgtctctt ggaaacagct ccccaccaac     3180

caagatttct ttttctaact tctgctacta agtttttaaa aattcccttt atgcacccaa     3240

gagatattta ttaaacacca attacgtagc aggccatggc tcatgggacc caccccccgt     3300

ggcactcatg gagggggctg caggttggaa ctatgcagtg tgctccggcc acacatcctg     3360

ctgggccccc taccctgccc caattcaatc ctgccaataa atcctgtctt atttgttcat     3420

cctggagaat tgaagggagg tcaagttgtt tgtcaatgat ttgtcagaga acctgttgaa     3480

atgtgaatta agaagctaag aaaatatttc ttagcaacat tttctttttc tttttttttt     3540

ttttcttttg agacagagtc tcactctcgt cgcccaggct ggaatgcagt ggtgcgatct     3600

cggctctctg caacctctgt ctcccgggtt caagcgattt cctgcgtcag ccccagagta     3660

gctggaatta caggcacaca ccaccacgcc tggctaattt ttgtattttt agtagagctg     3720

gggccaccct ggcccggccc cgtcttcctc cccaaaggtc agactgcagg ctgcagggct     3780

gtgctggagg agccagctct agctcaccca tgcttttgca acagggtcgg gttggaagtc     3840

agcacaggtc agtcctgcgg aaggttcctt cgtgactcat ctgtgaagtg gggtggttgg     3900

gagaggtagc tgagagaatg catgagagtc ctcggtgcct ggcaggaggc tggaaggttc     3960

tagaacactg atggttataa gagtgggact gtgagcctgg gatcgggggg tgtgagactt     4020

ggatgggagc acaagagtgg aaacacagct tctgcacgga gcaggcgcag ccctcaacac     4080

cccgtgcacc tgcaccctag ggactcttgg gtccagatgt gctgtggttt tcacaccttc     4140

ttgggggcaa caggttccag gagccacctg tgggtgccac ctgagccaca ggctcccagg     4200

aaagcagcac agctctcctg cacccagagc ttgctgggtg gcggagggga acacagatgg     4260

ttggggaagg cctgaggcca gattggggga ctctggactg gggcagatga ggctcctcag     4320

aatcccacct ttgaagggaa ctcagcttat aaacacagag gagcaaagtt ggagggccgg     4380

gcgtagtggc tcacacctgt gatctcagca ctttgggagg ccaaggaagg tggatcactt     4440

gaggccagga gttcgagacc agcctgggca acatagcaag gccccatctc tacaaaaatt     4500

attatttttt aaaaaaatta gccaggtgtg gtggtgcttg cctatagtcc cagctactcg     4560

ggaggctaag gtgggaggat cgctggagcc caggaatttg aggctgcagt gagctgtgat     4620

tacaccgttg cactccagcc tgggtcacag atcaagaccc tgtctcttaa aaataaaagt     4680

tggagacaag agctggctca cctgaaagga gggattagta ggtaggaggg tggatggagg     4740

atggatggat gtgtgggtgg ataggaagat ggtattaagt tggtgcaaaa gtctttgata     4800

ttactcttaa tggctttaat aaaaagcttg aaggaagaat gattggttgg atagacagag     4860

ataaatgcat actggaaaca aagataaaga taaaacacaa gttataccag gccagcaact     4920

ctattttgtt cactgccttt agtcccagcc tggcacatag taggcactca ataaagcctg     4980

atttgtagca aaaaaaaaaa aaaaaa                                          5006


<210>  10
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Pro Arg Gly Trp Ala Ala Pro Leu Leu Leu Leu Leu Leu Gln Gly 
1               5                   10                  15      


Gly Trp Gly Cys Pro Asp Leu Val Cys Tyr Thr Asp Tyr Leu Gln Thr 
            20                  25                  30          


Val Ile Cys Ile Leu Glu Met Trp Asn Leu His Pro Ser Thr Leu Thr 
        35                  40                  45              


Leu Thr Trp Gln Asp Gln Tyr Glu Glu Leu Lys Asp Glu Ala Thr Ser 
    50                  55                  60                  


Cys Ser Leu His Arg Ser Ala His Asn Ala Thr His Ala Thr Tyr Thr 
65                  70                  75                  80  


Cys His Met Asp Val Phe His Phe Met Ala Asp Asp Ile Phe Ser Val 
                85                  90                  95      


Asn Ile Thr Asp Gln Ser Gly Asn Tyr Ser Gln Glu Cys Gly Ser Phe 
            100                 105                 110         


Leu Leu Ala Glu Ser Ile Lys Pro Ala Pro Pro Phe Asn Val Thr Val 
        115                 120                 125             


Thr Phe Ser Gly Gln Tyr Asn Ile Ser Trp Arg Ser Asp Tyr Glu Asp 
    130                 135                 140                 


Pro Ala Phe Tyr Met Leu Lys Gly Lys Leu Gln Tyr Glu Leu Gln Tyr 
145                 150                 155                 160 


Arg Asn Arg Gly Asp Pro Trp Ala Val Ser Pro Arg Arg Lys Leu Ile 
                165                 170                 175     


Ser Val Asp Ser Arg Ser Val Ser Leu Leu Pro Leu Glu Phe Arg Lys 
            180                 185                 190         


Asp Ser Ser Tyr Glu Leu Gln Val Arg Ala Gly Pro Met Pro Gly Ser 
        195                 200                 205             


Ser Tyr Gln Gly Thr Trp Ser Glu Trp Ser Asp Pro Val Ile Phe Gln 
    210                 215                 220                 


Thr Gln Ser Glu Glu Leu Lys Glu Gly Trp Asn Pro His Leu Leu Leu 
225                 230                 235                 240 


Leu Leu Leu Leu Val Ile Val Phe Ile Pro Ala Phe Trp Ser Leu Lys 
                245                 250                 255     


Thr His Pro Leu Trp Arg Leu Trp Lys Lys Ile Trp Ala Val Pro Ser 
            260                 265                 270         


Pro Glu Arg Phe Phe Met Pro Leu Tyr Lys Gly Cys Ser Gly Asp Phe 
        275                 280                 285             


Lys Lys Trp Val Gly Ala Pro Phe Thr Gly Ser Ser Leu Glu Leu Gly 
    290                 295                 300                 


Pro Trp Ser Pro Glu Val Pro Ser Thr Leu Glu Val Tyr Ser Cys His 
305                 310                 315                 320 


Pro Pro Arg Ser Pro Ala Lys Arg Leu Gln Leu Thr Glu Leu Gln Glu 
                325                 330                 335     


Pro Ala Glu Leu Val Glu Ser Asp Gly Val Pro Lys Pro Ser Phe Trp 
            340                 345                 350         


Pro Thr Ala Gln Asn Ser Gly Gly Ser Ala Tyr Ser Glu Glu Arg Asp 
        355                 360                 365             


Arg Pro Tyr Gly Leu Val Ser Ile Asp Thr Val Thr Val Leu Asp Ala 
    370                 375                 380                 


Glu Gly Pro Cys Thr Trp Pro Cys Ser Cys Glu Asp Asp Gly Tyr Pro 
385                 390                 395                 400 


Ala Leu Asp Leu Asp Ala Gly Leu Glu Pro Ser Pro Gly Leu Glu Asp 
                405                 410                 415     


Pro Leu Leu Asp Ala Gly Thr Thr Val Leu Ser Cys Gly Cys Val Ser 
            420                 425                 430         


Ala Gly Ser Pro Gly Leu Gly Gly Pro Leu Gly Ser Leu Leu Asp Arg 
        435                 440                 445             


Leu Lys Pro Pro Leu Ala Asp Gly Glu Asp Trp Ala Gly Gly Leu Pro 
    450                 455                 460                 


Trp Gly Gly Arg Ser Pro Gly Gly Val Ser Glu Ser Glu Ala Gly Ser 
465                 470                 475                 480 


Pro Leu Ala Gly Leu Asp Met Asp Thr Phe Asp Ser Gly Phe Val Gly 
                485                 490                 495     


Ser Asp Cys Ser Ser Pro Val Glu Cys Asp Phe Thr Ser Pro Gly Asp 
            500                 505                 510         


Glu Gly Pro Pro Arg Ser Tyr Leu Arg Gln Trp Val Val Ile Pro Pro 
        515                 520                 525             


Pro Leu Ser Ser Pro Gly Pro Gln Ala Ser 
    530                 535             


<210>  11
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Pro Arg Gly Trp Ala Ala Pro Leu Leu Leu Leu Leu Leu Gln Gly 
1               5                   10                  15      


Gly Trp Gly Cys Pro Asp Leu Val Cys Tyr Thr Asp Tyr Leu Gln Thr 
            20                  25                  30          


Val Ile Cys Ile Leu Glu Met Trp Asn Leu His Pro Ser Thr Leu Thr 
        35                  40                  45              


Leu Thr Trp Gln Asp Gln Tyr Glu Glu Leu Lys Asp Glu Ala Thr Ser 
    50                  55                  60                  


Cys Ser Leu His Arg Ser Ala His Asn Ala Thr His Ala Thr Tyr Thr 
65                  70                  75                  80  


Cys His Met Asp Val Phe His Phe Met Ala Asp Asp Ile Phe Ser Val 
                85                  90                  95      


Asn Ile Thr Asp Gln Ser Gly Asn Tyr Ser Gln Glu Cys Gly Ser Phe 
            100                 105                 110         


Leu Leu Ala Glu Ser Ile Lys Pro Ala Pro Pro Phe Asn Val Thr Val 
        115                 120                 125             


Thr Phe Ser Gly Gln Tyr Asn Ile Ser Trp Arg Ser Asp Tyr Glu Asp 
    130                 135                 140                 


Pro Ala Phe Tyr Met Leu Lys Gly Lys Leu Gln Tyr Glu Leu Gln Tyr 
145                 150                 155                 160 


Arg Asn Arg Gly Asp Pro Trp Ala Val Ser Pro Arg Arg Lys Leu Ile 
                165                 170                 175     


Ser Val Asp Ser Arg Ser Val Ser Leu Leu Pro Leu Glu Phe Arg Lys 
            180                 185                 190         


Asp Ser Ser Tyr Glu Leu Gln Val Arg Ala Gly Pro Met Pro Gly Ser 
        195                 200                 205             


Ser Tyr Gln Gly Thr Trp Ser Glu Trp Ser Asp Pro Val Ile Phe Gln 
    210                 215                 220                 


Thr Gln Ser Glu Glu Leu Lys Glu Gly Trp Asn Pro His Leu Leu Leu 
225                 230                 235                 240 


Leu Leu Leu Leu Val Ile Val Phe Ile Pro Ala Phe Trp Ser Leu Lys 
                245                 250                 255     


Thr His Pro Leu Trp Arg Leu Trp Lys Lys Ile Trp Ala Val Pro Ser 
            260                 265                 270         


Pro Glu Arg Phe Phe Met Pro Leu Tyr Lys Gly Cys Ser Gly Asp Phe 
        275                 280                 285             


Lys Lys Trp Val Gly Ala Pro Phe Thr Gly Ser Ser Leu Glu Leu Gly 
    290                 295                 300                 


Pro Trp Ser Pro Glu Val Pro Ser Thr Leu Glu Val Tyr Ser Cys His 
305                 310                 315                 320 


Pro Pro Arg Ser Pro Ala Lys Arg Leu Gln Leu Thr Glu Leu Gln Glu 
                325                 330                 335     


Pro Ala Glu Leu Val Glu Ser Asp Gly Val Pro Lys Pro Ser Phe Trp 
            340                 345                 350         


Pro Thr Ala Gln Asn Ser Gly Gly Ser Ala Tyr Ser Glu Glu Arg Asp 
        355                 360                 365             


Arg Pro Tyr Gly Leu Val Ser Ile Asp Thr Val Thr Val Leu Asp Ala 
    370                 375                 380                 


Glu Gly Pro Cys Thr Trp Pro Cys Ser Cys Glu Asp Asp Gly Tyr Pro 
385                 390                 395                 400 


Ala Leu Asp Leu Asp Ala Gly Leu Glu Pro Ser Pro Gly Leu Glu Asp 
                405                 410                 415     


Pro Leu Leu Asp Ala Gly Thr Thr Val Leu Ser Cys Gly Cys Val Ser 
            420                 425                 430         


Ala Gly Ser Pro Gly Leu Gly Gly Pro Leu Gly Ser Leu Leu Asp Arg 
        435                 440                 445             


Leu Lys Pro Pro Leu Ala Asp Gly Glu Asp Trp Ala Gly Gly Leu Pro 
    450                 455                 460                 


Trp Gly Gly Arg Ser Pro Gly Gly Val Ser Glu Ser Glu Ala Gly Ser 
465                 470                 475                 480 


Pro Leu Ala Gly Leu Asp Met Asp Thr Phe Asp Ser Gly Phe Val Gly 
                485                 490                 495     


Ser Asp Cys Ser Ser Pro Val Glu Cys Asp Phe Thr Ser Pro Gly Asp 
            500                 505                 510         


Glu Gly Pro Pro Arg Ser Tyr Leu Arg Gln Trp Val Val Ile Pro Pro 
        515                 520                 525             


Pro Leu Ser Ser Pro Gly Pro Gln Ala Ser 
    530                 535             


<210>  12
<211>  560
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ser Cys Arg Cys Ile Phe Leu Met Lys His Gly Glu Arg Val Gly 
1               5                   10                  15      


Trp Pro Val Gly Val Ser Met Pro Arg Gly Trp Ala Ala Pro Leu Leu 
            20                  25                  30          


Leu Leu Leu Leu Gln Gly Gly Trp Gly Cys Pro Asp Leu Val Cys Tyr 
        35                  40                  45              


Thr Asp Tyr Leu Gln Thr Val Ile Cys Ile Leu Glu Met Trp Asn Leu 
    50                  55                  60                  


His Pro Ser Thr Leu Thr Leu Thr Trp Gln Asp Gln Tyr Glu Glu Leu 
65                  70                  75                  80  


Lys Asp Glu Ala Thr Ser Cys Ser Leu His Arg Ser Ala His Asn Ala 
                85                  90                  95      


Thr His Ala Thr Tyr Thr Cys His Met Asp Val Phe His Phe Met Ala 
            100                 105                 110         


Asp Asp Ile Phe Ser Val Asn Ile Thr Asp Gln Ser Gly Asn Tyr Ser 
        115                 120                 125             


Gln Glu Cys Gly Ser Phe Leu Leu Ala Glu Ser Ile Lys Pro Ala Pro 
    130                 135                 140                 


Pro Phe Asn Val Thr Val Thr Phe Ser Gly Gln Tyr Asn Ile Ser Trp 
145                 150                 155                 160 


Arg Ser Asp Tyr Glu Asp Pro Ala Phe Tyr Met Leu Lys Gly Lys Leu 
                165                 170                 175     


Gln Tyr Glu Leu Gln Tyr Arg Asn Arg Gly Asp Pro Trp Ala Val Ser 
            180                 185                 190         


Pro Arg Arg Lys Leu Ile Ser Val Asp Ser Arg Ser Val Ser Leu Leu 
        195                 200                 205             


Pro Leu Glu Phe Arg Lys Asp Ser Ser Tyr Glu Leu Gln Val Arg Ala 
    210                 215                 220                 


Gly Pro Met Pro Gly Ser Ser Tyr Gln Gly Thr Trp Ser Glu Trp Ser 
225                 230                 235                 240 


Asp Pro Val Ile Phe Gln Thr Gln Ser Glu Glu Leu Lys Glu Gly Trp 
                245                 250                 255     


Asn Pro His Leu Leu Leu Leu Leu Leu Leu Val Ile Val Phe Ile Pro 
            260                 265                 270         


Ala Phe Trp Ser Leu Lys Thr His Pro Leu Trp Arg Leu Trp Lys Lys 
        275                 280                 285             


Ile Trp Ala Val Pro Ser Pro Glu Arg Phe Phe Met Pro Leu Tyr Lys 
    290                 295                 300                 


Gly Cys Ser Gly Asp Phe Lys Lys Trp Val Gly Ala Pro Phe Thr Gly 
305                 310                 315                 320 


Ser Ser Leu Glu Leu Gly Pro Trp Ser Pro Glu Val Pro Ser Thr Leu 
                325                 330                 335     


Glu Val Tyr Ser Cys His Pro Pro Arg Ser Pro Ala Lys Arg Leu Gln 
            340                 345                 350         


Leu Thr Glu Leu Gln Glu Pro Ala Glu Leu Val Glu Ser Asp Gly Val 
        355                 360                 365             


Pro Lys Pro Ser Phe Trp Pro Thr Ala Gln Asn Ser Gly Gly Ser Ala 
    370                 375                 380                 


Tyr Ser Glu Glu Arg Asp Arg Pro Tyr Gly Leu Val Ser Ile Asp Thr 
385                 390                 395                 400 


Val Thr Val Leu Asp Ala Glu Gly Pro Cys Thr Trp Pro Cys Ser Cys 
                405                 410                 415     


Glu Asp Asp Gly Tyr Pro Ala Leu Asp Leu Asp Ala Gly Leu Glu Pro 
            420                 425                 430         


Ser Pro Gly Leu Glu Asp Pro Leu Leu Asp Ala Gly Thr Thr Val Leu 
        435                 440                 445             


Ser Cys Gly Cys Val Ser Ala Gly Ser Pro Gly Leu Gly Gly Pro Leu 
    450                 455                 460                 


Gly Ser Leu Leu Asp Arg Leu Lys Pro Pro Leu Ala Asp Gly Glu Asp 
465                 470                 475                 480 


Trp Ala Gly Gly Leu Pro Trp Gly Gly Arg Ser Pro Gly Gly Val Ser 
                485                 490                 495     


Glu Ser Glu Ala Gly Ser Pro Leu Ala Gly Leu Asp Met Asp Thr Phe 
            500                 505                 510         


Asp Ser Gly Phe Val Gly Ser Asp Cys Ser Ser Pro Val Glu Cys Asp 
        515                 520                 525             


Phe Thr Ser Pro Gly Asp Glu Gly Pro Pro Arg Ser Tyr Leu Arg Gln 
    530                 535                 540                 


Trp Val Val Ile Pro Pro Pro Leu Ser Ser Pro Gly Pro Gln Ala Ser 
545                 550                 555                 560 


<210>  13
<211>  2607
<212>  DNA
<213>  Mus musculus

<400>  13
agatagacac cgaagcctcc gctggtggcc ctgtgtttca gtcgcacaca gctgtctgcc       60

cacttctcct gtggtgtgcc tcacggtcac ttgcttgtct gaccgcaagt ctgcccatcc      120

ctggggcagc caactggcct cagcccgtgc cccaggcgtg ccctgtctct gtctggctgc      180

cccagcccta ctgtcttcct ctgtgtaggc tctgcccaga tgcccggctg gtcctcagcc      240

tcaggactat ctcagcagtg actcccctga ttctggactt gcacctgact gaactcctgc      300

ccacctcaaa ccttcacctc ccaccaccac cactccgagt cccgctgtga ctcccacgcc      360

caggagacca cccaagtgcc ccagcctaaa gaatggcttt ctgagaaaga ccctgaagga      420

gtaggtctgg gacacagcat gccccggggc ccagtggctg ccttactcct gctgattctc      480

catggagctt ggagctgcct ggacctcact tgctacactg actacctctg gaccatcacc      540

tgtgtcctgg agacacggag ccccaacccc agcatactca gtctcacctg gcaagatgaa      600

tatgaggaac ttcaggacca agagaccttc tgcagcctac acaggtctgg ccacaacacc      660

acacatatat ggtacacgtg ccatatgcgc ttgtctcaat tcctgtccga tgaagttttc      720

attgtcaatg tgacggacca gtctggcaac aactcccaag agtgtggcag ctttgtcctg      780

gctgagagca tcaaaccagc tccccccttg aacgtgactg tggccttctc aggacgctat      840

gatatctcct gggactcagc ttatgacgaa ccctccaact acgtgctgag gggcaagcta      900

caatatgagc tgcagtatcg gaacctcaga gacccctatg ctgtgaggcc ggtgaccaag      960

ctgatctcag tggactcaag aaacgtctct cttctccctg aagagttcca caaagattct     1020

agctaccagc tgcaggtgcg ggcagcgcct cagccaggca cttcattcag ggggacctgg     1080

agtgagtgga gtgaccccgt catctttcag acccaggctg gggagcccga ggcaggctgg     1140

gaccctcaca tgctgctgct cctggctgtc ttgatcattg tcctggtttt catgggtctg     1200

aagatccacc tgccttggag gctatggaaa aagatatggg caccagtgcc cacccctgag     1260

agtttcttcc agcccctgta cagggagcac agcgggaact tcaagaaatg ggttaatacc     1320

cctttcacgg cctccagcat agagttggtg ccacagagtt ccacaacaac atcagcctta     1380

catctgtcat tgtatccagc caaggagaag aagttcccgg ggctgccggg tctggaagag     1440

caactggagt gtgatggaat gtctgagcct ggtcactggt gcataatccc cttggcagct     1500

ggccaagcgg tctcagccta cagtgaggag agagaccggc catatggtct ggtgtccatt     1560

gacacagtga ctgtgggaga tgcagagggc ctgtgtgtct ggccctgtag ctgtgaggat     1620

gatggctatc cagccatgaa cctggatgct ggccgagagt ctggccctaa ttcagaggat     1680

ctgctcttgg tcacagaccc tgcttttctg tcttgcggct gtgtctcagg tagtggtctc     1740

aggcttggag gctccccagg cagcctactg gacaggttga ggctgtcatt tgcaaaggaa     1800

ggggactgga cagcagaccc aacctggaga actgggtccc caggaggggg ctctgagagt     1860

gaagcaggtt ccccccctgg tctggacatg gacacatttg acagtggctt tgcaggttca     1920

gactgtggca gccccgtgga gactgatgaa ggaccccctc gaagctatct ccgccagtgg     1980

gtggtcagga cccctccacc tgtggacagt ggagcccaga gcagctagca tataataacc     2040

agctatagtg agaagaggcc tctgagcctg gcatttacag tgtgaacatg taggggtgtg     2100

tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tcttgggttg tgtgttagca catccatgtt     2160

gggatttggt ctgttgctat gtattgtaat gctaaattct ctacccaaag ttctaggcct     2220

acgagtgaat tctcatgttt acaaacttgc tgtgtaaacc ttgttcctta atttaatacc     2280

attggttaaa taaaattggc tgcaaccaat tactggaggg attagaggta gggggctttt     2340

gagttacctg tttggagatg gagaaggaga gaggagagac caagaggaga aggaggaagg     2400

agaggagagg agaggagagg agaggagagg agaggagagg agaggagagg agaggagagg     2460

ctgccgtgag gggagaggga ccatgagcct gtggccagga gaaacagcaa gtatctgggg     2520

tacactggtg aggaggtggc caggccagca gttagaagag tagattaggg gtgacctcca     2580

gtatttgtca aagccaatta aaataac                                         2607


<210>  14
<211>  529
<212>  PRT
<213>  Mus musculus

<400>  14

Met Pro Arg Gly Pro Val Ala Ala Leu Leu Leu Leu Ile Leu His Gly 
1               5                   10                  15      


Ala Trp Ser Cys Leu Asp Leu Thr Cys Tyr Thr Asp Tyr Leu Trp Thr 
            20                  25                  30          


Ile Thr Cys Val Leu Glu Thr Arg Ser Pro Asn Pro Ser Ile Leu Ser 
        35                  40                  45              


Leu Thr Trp Gln Asp Glu Tyr Glu Glu Leu Gln Asp Gln Glu Thr Phe 
    50                  55                  60                  


Cys Ser Leu His Arg Ser Gly His Asn Thr Thr His Ile Trp Tyr Thr 
65                  70                  75                  80  


Cys His Met Arg Leu Ser Gln Phe Leu Ser Asp Glu Val Phe Ile Val 
                85                  90                  95      


Asn Val Thr Asp Gln Ser Gly Asn Asn Ser Gln Glu Cys Gly Ser Phe 
            100                 105                 110         


Val Leu Ala Glu Ser Ile Lys Pro Ala Pro Pro Leu Asn Val Thr Val 
        115                 120                 125             


Ala Phe Ser Gly Arg Tyr Asp Ile Ser Trp Asp Ser Ala Tyr Asp Glu 
    130                 135                 140                 


Pro Ser Asn Tyr Val Leu Arg Gly Lys Leu Gln Tyr Glu Leu Gln Tyr 
145                 150                 155                 160 


Arg Asn Leu Arg Asp Pro Tyr Ala Val Arg Pro Val Thr Lys Leu Ile 
                165                 170                 175     


Ser Val Asp Ser Arg Asn Val Ser Leu Leu Pro Glu Glu Phe His Lys 
            180                 185                 190         


Asp Ser Ser Tyr Gln Leu Gln Val Arg Ala Ala Pro Gln Pro Gly Thr 
        195                 200                 205             


Ser Phe Arg Gly Thr Trp Ser Glu Trp Ser Asp Pro Val Ile Phe Gln 
    210                 215                 220                 


Thr Gln Ala Gly Glu Pro Glu Ala Gly Trp Asp Pro His Met Leu Leu 
225                 230                 235                 240 


Leu Leu Ala Val Leu Ile Ile Val Leu Val Phe Met Gly Leu Lys Ile 
                245                 250                 255     


His Leu Pro Trp Arg Leu Trp Lys Lys Ile Trp Ala Pro Val Pro Thr 
            260                 265                 270         


Pro Glu Ser Phe Phe Gln Pro Leu Tyr Arg Glu His Ser Gly Asn Phe 
        275                 280                 285             


Lys Lys Trp Val Asn Thr Pro Phe Thr Ala Ser Ser Ile Glu Leu Val 
    290                 295                 300                 


Pro Gln Ser Ser Thr Thr Thr Ser Ala Leu His Leu Ser Leu Tyr Pro 
305                 310                 315                 320 


Ala Lys Glu Lys Lys Phe Pro Gly Leu Pro Gly Leu Glu Glu Gln Leu 
                325                 330                 335     


Glu Cys Asp Gly Met Ser Glu Pro Gly His Trp Cys Ile Ile Pro Leu 
            340                 345                 350         


Ala Ala Gly Gln Ala Val Ser Ala Tyr Ser Glu Glu Arg Asp Arg Pro 
        355                 360                 365             


Tyr Gly Leu Val Ser Ile Asp Thr Val Thr Val Gly Asp Ala Glu Gly 
    370                 375                 380                 


Leu Cys Val Trp Pro Cys Ser Cys Glu Asp Asp Gly Tyr Pro Ala Met 
385                 390                 395                 400 


Asn Leu Asp Ala Gly Arg Glu Ser Gly Pro Asn Ser Glu Asp Leu Leu 
                405                 410                 415     


Leu Val Thr Asp Pro Ala Phe Leu Ser Cys Gly Cys Val Ser Gly Ser 
            420                 425                 430         


Gly Leu Arg Leu Gly Gly Ser Pro Gly Ser Leu Leu Asp Arg Leu Arg 
        435                 440                 445             


Leu Ser Phe Ala Lys Glu Gly Asp Trp Thr Ala Asp Pro Thr Trp Arg 
    450                 455                 460                 


Thr Gly Ser Pro Gly Gly Gly Ser Glu Ser Glu Ala Gly Ser Pro Pro 
465                 470                 475                 480 


Gly Leu Asp Met Asp Thr Phe Asp Ser Gly Phe Ala Gly Ser Asp Cys 
                485                 490                 495     


Gly Ser Pro Val Glu Thr Asp Glu Gly Pro Pro Arg Ser Tyr Leu Arg 
            500                 505                 510         


Gln Trp Val Val Arg Thr Pro Pro Pro Val Asp Ser Gly Ala Gln Ser 
        515                 520                 525             


Ser 
    


