                         SEQUENCE LISTING

<110>  RINAT NEUROSCIENCE CORP.
 
<120>  HUMAN GROWTH HORMONE RECEPTOR ANTAGONIST ANTIBODIES AND METHODS 
       OF USE THEREOF

<130>  PC33925A

<150>  61/579,618
<151>  2011-12-22

<160>  146   

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  1

Gly Phe Thr Phe Ser Asp Ala Trp Met Asp 
1               5                   10  


<210>  2
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  2

Glu Ile Arg Ser Lys Ala Asn Tyr His Ala Thr Tyr Tyr Ala Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  3

Ile Arg Asp Tyr Trp 
1               5   


<210>  4
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  4

Thr Ala Thr Ser Ser Val Ser Ser Ser Tyr Leu Asn 
1               5                   10          


<210>  5
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  5

Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  6

His Gln Tyr His Arg Ser Thr Pro Thr 
1               5                   


<210>  7
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  7

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Thr Ala Thr Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Tyr His Arg Ser Thr 
                85                  90                  95      


Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  8
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  8

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Ser Lys Ala Asn Tyr His Ala Thr Tyr Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Leu Ile Arg Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  9
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  9

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Thr Ala Thr Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Tyr His Arg Phe Thr 
                85                  90                  95      


Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  10
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  10

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Ser Lys Ala Asn Asn His Ala Thr Tyr Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Leu Phe Arg Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  11
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  11

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Thr Ala Thr Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Tyr His Arg Ser Thr 
                85                  90                  95      


Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  12
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  12

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Ser Lys Ala Asn Asn His Ala Thr Tyr Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Leu Tyr Arg Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  13
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  13

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Thr Ala Thr Ser Ser Val Ser Ser Trp 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Tyr His Arg Ser Thr 
                85                  90                  95      


Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  14
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  14

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Thr Ala Thr Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Tyr His Arg Gly Thr 
                85                  90                  95      


Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  15
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  15

Gly Phe Thr Phe Ser Asp Ala 
1               5           


<210>  16
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  16

Asp Ala Trp Met Asp 
1               5   


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  17

Arg Ser Lys Ala Asn Tyr His Ala 
1               5               


<210>  18
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  18

Thr Ala Thr Ser Ser Val Ser Ser Ser Tyr Leu His 
1               5                   10          


<210>  19
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  19

Arg Ser Lys Ala Asn Asn His Ala 
1               5               


<210>  20
<211>  19
<212>  PRT
<213>  Mus musculus

<400>  20

Glu Ile Arg Ser Lys Ala Asn Asn His Ala Thr Tyr Tyr Ala Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  21
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  21

Tyr Arg Asp Tyr Trp 
1               5   


<210>  22
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  22

Thr Ala Thr Ser Ser Val Ser Ser Trp Tyr Leu His 
1               5                   10          


<210>  23
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  23

Thr Ala Thr Ser Ser Val Ser Ser Phe Tyr Leu His 
1               5                   10          


<210>  24
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  24

Thr Ala Thr Ser Ser Val Ser Ser Ser Tyr Leu Asp 
1               5                   10          


<210>  25
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  25

His Gln Tyr His Arg Phe Thr Pro Thr 
1               5                   


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  26

Arg Ser Lys Ala Asn Phe His Ala 
1               5               


<210>  27
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  27

Glu Ile Arg Ser Lys Ala Asn Phe His Ala Thr Tyr Tyr Ala Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  28

Arg Ser Lys Ala Asn Asn Phe Ala 
1               5               


<210>  29
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  29

Glu Ile Arg Ser Lys Ala Asn Asn Phe Ala Thr Tyr Tyr Ala Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  30
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  30

Phe Arg Asp Tyr Trp 
1               5   


<210>  31
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  31

Ile Tyr Arg Asp Tyr Trp 
1               5       


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  32

His Gln Tyr His Arg Arg Thr Pro Thr 
1               5                   


<210>  33
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  33

His Gln Tyr His Arg Tyr Thr Pro Thr 
1               5                   


<210>  34
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  34

His Gln Tyr His Arg His Thr Pro Thr 
1               5                   


<210>  35
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  35

His Gln Tyr His Arg Gln Thr Pro Thr 
1               5                   


<210>  36
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  36

His Gln Tyr His Arg Gly Thr Pro Thr 
1               5                   


<210>  37
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  37

His Gln Tyr His Arg Ser Tyr Pro Thr 
1               5                   


<210>  38
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  38

His Gln Tyr His Arg Ser Phe Pro Thr 
1               5                   


<210>  39
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  39

His Gln Tyr His Arg Ser Ile Pro Thr 
1               5                   


<210>  40
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  40

His Gln Tyr His Arg Ser Trp Pro Thr 
1               5                   


<210>  41
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  41

Arg Ala Thr Ser Ser Val Ser Ser Ser Tyr Leu His 
1               5                   10          


<210>  42
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  42

Glu Ala Thr Ser Ser Val Ser Ser Ser Tyr Leu His 
1               5                   10          


<210>  43
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  43

Thr Pro Thr Ser Ser Val Ser Ser Ser Tyr Leu His 
1               5                   10          


<210>  44
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  44

Thr Ala Ser Ser Ser Val Ser Ser Ser Tyr Leu His 
1               5                   10          


<210>  45
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  45

Thr Ala Thr Thr Ser Val Ser Ser Ser Tyr Leu His 
1               5                   10          


<210>  46
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  46

Thr Ala Thr Arg Ser Val Ser Ser Ser Tyr Leu His 
1               5                   10          


<210>  47
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  47

Thr Ala Thr Trp Ser Val Ser Ser Ser Tyr Leu His 
1               5                   10          


<210>  48
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  48

Thr Ala Thr Phe Ser Val Ser Ser Ser Tyr Leu His 
1               5                   10          


<210>  49
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  49

Thr Ala Thr Ser Trp Val Ser Ser Ser Tyr Leu His 
1               5                   10          


<210>  50
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  50

Thr Ala Thr Ser Val Val Ser Ser Ser Tyr Leu His 
1               5                   10          


<210>  51
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  51

Thr Ala Thr Ser Asp Val Ser Ser Ser Tyr Leu His 
1               5                   10          


<210>  52
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  52

Thr Ala Thr Ser Ser Val Gly Ser Ser Tyr Leu His 
1               5                   10          


<210>  53
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  53

Thr Ala Thr Ser Ser Val Trp Ser Ser Tyr Leu His 
1               5                   10          


<210>  54
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  54

Thr Ala Thr Ser Ser Val Ser Pro Ser Tyr Leu His 
1               5                   10          


<210>  55
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  55

Thr Ala Thr Ser Ser Val Ser Gln Ser Tyr Leu His 
1               5                   10          


<210>  56
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  56

Thr Ala Thr Ser Ser Val Ser Ala Ser Tyr Leu His 
1               5                   10          


<210>  57
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  57

Thr Ala Thr Ser Ser Val Ser Ser Gly Tyr Leu His 
1               5                   10          


<210>  58
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  58

Thr Ala Thr Ser Ser Val Ser Ser Ile Tyr Leu His 
1               5                   10          


<210>  59
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  59

Thr Ala Thr Ser Ser Val Ser Ser Glu Tyr Leu His 
1               5                   10          


<210>  60
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  60

Thr Ala Thr Ser Ser Val Ser Ser Ser Trp Leu His 
1               5                   10          


<210>  61
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  61

Thr Ala Thr Ser Ser Val Ser Ser Ser Tyr Val His 
1               5                   10          


<210>  62
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  62

Thr Ala Thr Ser Ser Val Ser Ser Ser Tyr Phe His 
1               5                   10          


<210>  63
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  63

Thr Ala Thr Ser Ser Val Ser Ser Ser Tyr Leu Pro 
1               5                   10          


<210>  64
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  64

Arg Ala Lys Ala Asn Asn His Ala 
1               5               


<210>  65
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  65

Glu Ile Arg Ala Lys Ala Asn Asn His Ala Thr Tyr Tyr Ala Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  66
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  66

His Gln Tyr His Arg Ser Ala Pro Thr 
1               5                   


<210>  67
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  67

Arg Thr Lys Ala Asn Asn His Ala 
1               5               


<210>  68
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  68

Glu Ile Arg Thr Lys Ala Asn Asn His Ala Thr Tyr Tyr Ala Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  69
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  69

Arg Ser Arg Ala Asn Asn His Ala 
1               5               


<210>  70
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  70

Glu Ile Arg Ser Arg Ala Asn Asn His Ala Thr Tyr Tyr Ala Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  71
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  71

Arg Ser Glu Ala Asn Asn His Ala 
1               5               


<210>  72
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  72

Glu Ile Arg Ser Glu Ala Asn Asn His Ala Thr Tyr Tyr Ala Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  73
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  73

Arg Ser Lys Asp Asn Asn His Ala 
1               5               


<210>  74
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  74

Glu Ile Arg Ser Lys Asp Asn Asn His Ala Thr Tyr Tyr Ala Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  75
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  75

Arg Ser Lys Ser Asn Asn His Ala 
1               5               


<210>  76
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  76

Glu Ile Arg Ser Lys Ser Asn Asn His Ala Thr Tyr Tyr Ala Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  77
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  77

Arg Ser Lys Val Asn Asn His Ala 
1               5               


<210>  78
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  78

Glu Ile Arg Ser Lys Val Asn Asn His Ala Thr Tyr Tyr Ala Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  79
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  79

Arg Ser Lys Tyr Asn Asn His Ala 
1               5               


<210>  80
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  80

Glu Ile Arg Ser Lys Tyr Asn Asn His Ala Thr Tyr Tyr Ala Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  81
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  81

Arg Ser Lys Glu Asn Asn His Ala 
1               5               


<210>  82
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  82

Glu Ile Arg Ser Lys Glu Asn Asn His Ala Thr Tyr Tyr Ala Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  83
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  83

Arg Ser Lys Ala Asn Trp His Ala 
1               5               


<210>  84
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  84

Glu Ile Arg Ser Lys Ala Asn Trp His Ala Thr Tyr Tyr Ala Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  85
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  85

Arg Ser Lys Ala Asn Ile His Ala 
1               5               


<210>  86
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  86

Glu Ile Arg Ser Lys Ala Asn Ile His Ala Thr Tyr Tyr Ala Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  87
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  87

Arg Ser Lys Ala Asn Asp His Ala 
1               5               


<210>  88
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  88

Glu Ile Arg Ser Lys Ala Asn Asp His Ala Thr Tyr Tyr Ala Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  89
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  89

Arg Ser Lys Ala Asn Lys His Ala 
1               5               


<210>  90
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  90

Glu Ile Arg Ser Lys Ala Asn Lys His Ala Thr Tyr Tyr Ala Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  91
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  91

Arg Ser Lys Ala Asn Arg His Ala 
1               5               


<210>  92
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  92

Glu Ile Arg Ser Lys Ala Asn Arg His Ala Thr Tyr Tyr Ala Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  93
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  93

Arg Ser Lys Ala Asn Asn Trp Ala 
1               5               


<210>  94
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  94

Glu Ile Arg Ser Lys Ala Asn Asn Trp Ala Thr Tyr Tyr Ala Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  95
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  95

Arg Ser Lys Ala Asn Asn Ile Ala 
1               5               


<210>  96
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  96

Glu Ile Arg Ser Lys Ala Asn Asn Ile Ala Thr Tyr Tyr Ala Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  97
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  97

Arg Ser Lys Ala Asn Asn Tyr Ala 
1               5               


<210>  98
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  98

Glu Ile Arg Ser Lys Ala Asn Asn Tyr Ala Thr Tyr Tyr Ala Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  99
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa can be H, D, P, or N

<400>  99

Thr Ala Thr Ser Ser Val Ser Ser Ser Tyr Leu Xaa 
1               5                   10          


<210>  100
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa can be S, T, R, W, or F

<400>  100

Thr Ala Thr Xaa Ser Val Ser Ser Ser Tyr Leu His 
1               5                   10          


<210>  101
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be S, W, V, or D

<400>  101

Thr Ala Thr Ser Xaa Val Ser Ser Ser Tyr Leu His 
1               5                   10          


<210>  102
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa can be S, G, or W

<400>  102

Thr Ala Thr Ser Ser Val Xaa Ser Ser Tyr Leu His 
1               5                   10          


<210>  103
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa can be S, P, or Q

<400>  103

Thr Ala Thr Ser Ser Val Ser Xaa Ser Tyr Leu His 
1               5                   10          


<210>  104
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa can be S, G, I, E, W, or F

<400>  104

Thr Ala Thr Ser Ser Val Ser Ser Xaa Tyr Leu His 
1               5                   10          


<210>  105
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa can be L, V, or F

<400>  105

Thr Ala Thr Ser Ser Val Ser Ser Ser Tyr Xaa His 
1               5                   10          


<210>  106
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa can be S, F, R, Y, H, Q, or G

<400>  106

His Gln Tyr His Arg Xaa Thr Pro Thr 
1               5                   


<210>  107
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa can be T, Y, F, I, A, or W

<400>  107

His Gln Tyr His Arg Ser Xaa Pro Thr 
1               5                   


<210>  108
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa can be S, A, or T

<400>  108

Arg Xaa Lys Ala Asn Asn His Ala 
1               5               


<210>  109
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa can be S, A, or T

<400>  109

Glu Ile Arg Xaa Lys Ala Asn Asn His Ala Thr Tyr Tyr Ala Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  110
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa can be K, R, or E

<400>  110

Arg Ser Xaa Ala Asn Asn His Ala 
1               5               


<210>  111
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be K, R, or E

<400>  111

Glu Ile Arg Ser Xaa Ala Asn Asn His Ala Thr Tyr Tyr Ala Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  112
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa can be A, D, S, V, Y, or E

<400>  112

Arg Ser Lys Xaa Asn Asn His Ala 
1               5               


<210>  113
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa can be A, D, S, V, Y, or E

<400>  113

Glu Ile Arg Ser Lys Xaa Asn Asn His Ala Thr Tyr Tyr Ala Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  114
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa can be N, F, W, I, D, Y, K, or R

<400>  114

Arg Ser Lys Ala Asn Xaa His Ala 
1               5               


<210>  115
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa can be N, F, W, I, D, Y, K, or R

<400>  115

Glu Ile Arg Ser Lys Ala Asn Xaa His Ala Thr Tyr Tyr Ala Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  116
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa can be H, W, I, Y, or F

<400>  116

Arg Ser Lys Ala Asn Asn Xaa Ala 
1               5               


<210>  117
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa can be H, W, I, Y or F

<400>  117

Glu Ile Arg Ser Lys Ala Asn Asn Xaa Ala Thr Tyr Tyr Ala Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  118
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa can be Y, F, or I

<400>  118

Xaa Arg Asp Tyr Trp 
1               5   


<210>  119
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa can be L or I

<400>  119

Xaa Tyr Arg Asp Tyr Trp 
1               5       


<210>  120
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa can be S, W, or F

<400>  120

Thr Ala Thr Ser Ser Val Ser Ser Xaa Tyr Leu His 
1               5                   10          


<210>  121
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa can be H, D, or N

<400>  121

Thr Ala Thr Ser Ser Val Ser Ser Ser Tyr Leu Xaa 
1               5                   10          


<210>  122
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa can be T, Y, F, I, or W

<400>  122

His Gln Tyr His Arg Ser Xaa Pro Thr 
1               5                   


<210>  123
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa can be N, F, or Y

<400>  123

Arg Ser Lys Ala Asn Xaa His Ala 
1               5               


<210>  124
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa can be N, F, or Y

<400>  124

Glu Ile Arg Ser Lys Ala Asn Xaa His Ala Thr Tyr Tyr Ala Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  125
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa can be H or F

<400>  125

Arg Ser Lys Ala Asn Asn Xaa Ala 
1               5               


<210>  126
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa can be H or F

<400>  126

Glu Ile Arg Ser Lys Ala Asn Asn Xaa Ala Thr Tyr Tyr Ala Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  127
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa can be N or Y

<400>  127

Arg Ser Lys Ala Asn Xaa His Ala 
1               5               


<210>  128
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa can be N or Y

<400>  128

Glu Ile Arg Ser Lys Ala Asn Xaa His Ala Thr Tyr Tyr Ala Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  129
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa can be Y or I

<400>  129

Xaa Arg Asp Tyr Trp 
1               5   


<210>  130
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa can be S, F, R, Y, H or G

<400>  130

His Gln Tyr His Arg Xaa Thr Pro Thr 
1               5                   


<210>  131
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa can be H or D

<400>  131

Thr Ala Thr Ser Ser Val Ser Ser Ser Tyr Leu Xaa 
1               5                   10          


<210>  132
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa can be S or F

<400>  132

His Gln Tyr His Arg Xaa Thr Pro Thr 
1               5                   


<210>  133
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  133

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Ser Lys Ala Asn Tyr His Ala Thr Tyr Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Leu Ile Arg Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly 
            180                 185                 190         


Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440 


<210>  134
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  134

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Ser Lys Ala Asn Tyr His Ala Thr Tyr Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Leu Ile Arg Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly 
            180                 185                 190         


Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  135
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  135

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Thr Ala Thr Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Tyr His Arg Ser Thr 
                85                  90                  95      


Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  136
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  136

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Ser Lys Ala Asn Asn His Ala Thr Tyr Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Leu Phe Arg Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly 
            180                 185                 190         


Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  137
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  137

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Thr Ala Thr Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Tyr His Arg Phe Thr 
                85                  90                  95      


Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  138
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  138

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Ser Lys Ala Asn Tyr His Ala Thr Tyr Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Leu Ile Arg Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly 
            180                 185                 190         


Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  139
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  139

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Thr Ala Thr Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Tyr His Arg Ser Thr 
                85                  90                  95      


Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  140
<211>  638
<212>  PRT
<213>  Homo sapiens

<400>  140

Met Asp Leu Trp Gln Leu Leu Leu Thr Leu Ala Leu Ala Gly Ser Ser 
1               5                   10                  15      


Asp Ala Phe Ser Gly Ser Glu Ala Thr Ala Ala Ile Leu Ser Arg Ala 
            20                  25                  30          


Pro Trp Ser Leu Gln Ser Val Asn Pro Gly Leu Lys Thr Asn Ser Ser 
        35                  40                  45              


Lys Glu Pro Lys Phe Thr Lys Cys Arg Ser Pro Glu Arg Glu Thr Phe 
    50                  55                  60                  


Ser Cys His Trp Thr Asp Glu Val His His Gly Thr Lys Asn Leu Gly 
65                  70                  75                  80  


Pro Ile Gln Leu Phe Tyr Thr Arg Arg Asn Thr Gln Glu Trp Thr Gln 
                85                  90                  95      


Glu Trp Lys Glu Cys Pro Asp Tyr Val Ser Ala Gly Glu Asn Ser Cys 
            100                 105                 110         


Tyr Phe Asn Ser Ser Phe Thr Ser Ile Trp Ile Pro Tyr Cys Ile Lys 
        115                 120                 125             


Leu Thr Ser Asn Gly Gly Thr Val Asp Glu Lys Cys Phe Ser Val Asp 
    130                 135                 140                 


Glu Ile Val Gln Pro Asp Pro Pro Ile Ala Leu Asn Trp Thr Leu Leu 
145                 150                 155                 160 


Asn Val Ser Leu Thr Gly Ile His Ala Asp Ile Gln Val Arg Trp Glu 
                165                 170                 175     


Ala Pro Arg Asn Ala Asp Ile Gln Lys Gly Trp Met Val Leu Glu Tyr 
            180                 185                 190         


Glu Leu Gln Tyr Lys Glu Val Asn Glu Thr Lys Trp Lys Met Met Asp 
        195                 200                 205             


Pro Ile Leu Thr Thr Ser Val Pro Val Tyr Ser Leu Lys Val Asp Lys 
    210                 215                 220                 


Glu Tyr Glu Val Arg Val Arg Ser Lys Gln Arg Asn Ser Gly Asn Tyr 
225                 230                 235                 240 


Gly Glu Phe Ser Glu Val Leu Tyr Val Thr Leu Pro Gln Met Ser Gln 
                245                 250                 255     


Phe Thr Cys Glu Glu Asp Phe Tyr Phe Pro Trp Leu Leu Ile Ile Ile 
            260                 265                 270         


Phe Gly Ile Phe Gly Leu Thr Val Met Leu Phe Val Phe Leu Phe Ser 
        275                 280                 285             


Lys Gln Gln Arg Ile Lys Met Leu Ile Leu Pro Pro Val Pro Val Pro 
    290                 295                 300                 


Lys Ile Lys Gly Ile Asp Pro Asp Leu Leu Lys Glu Gly Lys Leu Glu 
305                 310                 315                 320 


Glu Val Asn Thr Ile Leu Ala Ile His Asp Ser Tyr Lys Pro Glu Phe 
                325                 330                 335     


His Ser Asp Asp Ser Trp Val Glu Phe Ile Glu Leu Asp Ile Asp Glu 
            340                 345                 350         


Pro Asp Glu Lys Thr Glu Glu Ser Asp Thr Asp Arg Leu Leu Ser Ser 
        355                 360                 365             


Asp His Glu Lys Ser His Ser Asn Leu Gly Val Lys Asp Gly Asp Ser 
    370                 375                 380                 


Gly Arg Thr Ser Cys Cys Glu Pro Asp Ile Leu Glu Thr Asp Phe Asn 
385                 390                 395                 400 


Ala Asn Asp Ile His Glu Gly Thr Ser Glu Val Ala Gln Pro Gln Arg 
                405                 410                 415     


Leu Lys Gly Glu Ala Asp Leu Leu Cys Leu Asp Gln Lys Asn Gln Asn 
            420                 425                 430         


Asn Ser Pro Tyr His Asp Ala Cys Pro Ala Thr Gln Gln Pro Ser Val 
        435                 440                 445             


Ile Gln Ala Glu Lys Asn Lys Pro Gln Pro Leu Pro Thr Glu Gly Ala 
    450                 455                 460                 


Glu Ser Thr His Gln Ala Ala His Ile Gln Leu Ser Asn Pro Ser Ser 
465                 470                 475                 480 


Leu Ser Asn Ile Asp Phe Tyr Ala Gln Val Ser Asp Ile Thr Pro Ala 
                485                 490                 495     


Gly Ser Val Val Leu Ser Pro Gly Gln Lys Asn Lys Ala Gly Met Ser 
            500                 505                 510         


Gln Cys Asp Met His Pro Glu Met Val Ser Leu Cys Gln Glu Asn Phe 
        515                 520                 525             


Leu Met Asp Asn Ala Tyr Phe Cys Glu Ala Asp Ala Lys Lys Cys Leu 
    530                 535                 540                 


Pro Val Ala Pro His Ile Lys Val Glu Ser His Ile Gln Pro Ser Leu 
545                 550                 555                 560 


Asn Gln Glu Asp Ile Tyr Ile Thr Thr Glu Ser Leu Thr Thr Ala Ala 
                565                 570                 575     


Gly Arg Pro Gly Thr Gly Glu His Val Pro Gly Ser Glu Met Pro Val 
            580                 585                 590         


Pro Asp Tyr Thr Ser Ile His Ile Val Gln Ser Pro Gln Gly Leu Ile 
        595                 600                 605             


Leu Asn Ala Thr Ala Leu Pro Leu Pro Asp Lys Glu Phe Leu Ser Ser 
    610                 615                 620                 


Cys Gly Tyr Val Ser Thr Asp Gln Leu Asn Lys Ile Met Pro 
625                 630                 635             


<210>  141
<211>  637
<212>  PRT
<213>  Macaca fascicularis

<400>  141

Met Asp Leu Trp Gln Leu Leu Leu Thr Phe Ala Leu Ala Gly Ser Ser 
1               5                   10                  15      


Asp Ala Phe Ser Gly Ser Glu Pro Thr Ala Ala Ile Leu Ser Arg Ala 
            20                  25                  30          


Ser Trp Ser Leu Gln Ser Val Asn Pro Asp Leu Lys Thr Asn Ser Ser 
        35                  40                  45              


Lys Glu Pro Lys Phe Thr Lys Cys Arg Ser Pro Glu Arg Glu Thr Phe 
    50                  55                  60                  


Ser Cys His Trp Thr Asp Ala Val His His Gly Leu Lys Ser Leu Gly 
65                  70                  75                  80  


Pro Ile Gln Leu Phe Tyr Thr Arg Arg Asn Ile Gln Glu Gln Thr Gln 
                85                  90                  95      


Glu Trp Lys Glu Cys Pro Asp Tyr Val Ser Ala Gly Glu Asn Ser Cys 
            100                 105                 110         


Tyr Phe Asn Ser Ser Phe Thr Ser Val Trp Ile Pro Tyr Cys Ile Lys 
        115                 120                 125             


Leu Thr Ser Asn Gly Asp Thr Val Asp Gly Lys Cys Phe Ser Val Asp 
    130                 135                 140                 


Glu Ile Val Gln Pro Asp Pro Pro Ile Ala Leu Asn Trp Thr Leu Leu 
145                 150                 155                 160 


Asn Val Ser Leu Thr Gly Ile His Ala Asp Ile Gln Val Arg Trp Glu 
                165                 170                 175     


Ala Pro Pro Asn Ala Asp Ile Gln Lys Gly Trp Met Val Leu Glu Tyr 
            180                 185                 190         


Glu Leu Gln Tyr Lys Glu Val Asn Glu Thr Lys Trp Lys Met Met Asp 
        195                 200                 205             


Pro Ile Leu Ser Thr Ser Val Pro Val Tyr Ser Leu Lys Val Asp Lys 
    210                 215                 220                 


Glu Tyr Glu Val Arg Val Arg Ser Lys Arg Arg Asn Ser Arg Asn Tyr 
225                 230                 235                 240 


Gly Glu Phe Ser Glu Val Leu Tyr Val Thr Leu Pro Gln Met Asn Gln 
                245                 250                 255     


Phe Thr Cys Glu Glu Asp Phe Tyr Phe Pro Trp Leu Leu Ile Ile Ile 
            260                 265                 270         


Phe Gly Ile Phe Gly Leu Thr Val Met Leu Phe Val Phe Leu Phe Ser 
        275                 280                 285             


Lys Gln Gln Arg Ile Lys Met Leu Ile Leu Pro Pro Val Pro Val Pro 
    290                 295                 300                 


Lys Ile Lys Gly Ile Asp Pro Asp Leu Leu Lys Glu Gly Lys Leu Glu 
305                 310                 315                 320 


Glu Val Asn Thr Ile Leu Ala Ile His Asp Ser Tyr Lys Pro Glu Phe 
                325                 330                 335     


His Ser Asp Asp Ser Trp Val Glu Phe Ile Glu Leu Asp Ile Asp Glu 
            340                 345                 350         


Pro Asp Glu Lys Asn Glu Gly Ser Asp Thr Asp Arg Leu Leu Ser Ser 
        355                 360                 365             


Asp His Gln Lys Ser His Ser Asn Leu Gly Val Lys Asp Gly Asp Ser 
    370                 375                 380                 


Gly Arg Thr Ser Cys Tyr Glu Pro Asp Ile Leu Glu Thr Asp Phe Asn 
385                 390                 395                 400 


Ala Asn Asn Ile His Glu Gly Thr Ser Glu Val Ala Gln Pro Gln Arg 
                405                 410                 415     


Leu Lys Gly Glu Ala Asp Leu Leu Cys Leu Asp Gln Lys Asn Gln Asn 
            420                 425                 430         


Lys Pro Pro Tyr His Asp Ala Cys Pro Ala Thr Gln Gln Pro Ser Val 
        435                 440                 445             


Ile Gln Ala Glu Lys Asn Lys Pro Gln Pro Leu Pro Thr Asp Gly Ala 
    450                 455                 460                 


Glu Ser Thr His Gln Ala Ala His Ile Gln Leu Ser Asn Pro Ser Ser 
465                 470                 475                 480 


Leu Ala Asn Ile Asp Phe Tyr Ala Gln Val Ser Asp Ile Thr Pro Ala 
                485                 490                 495     


Gly Ser Val Val Leu Ser Pro Gly Gln Lys Asn Lys Ala Gly Met Ser 
            500                 505                 510         


Gln Cys Asp Met His Leu Glu Met Val Ser Leu Cys Gln Glu Asp Phe 
        515                 520                 525             


Ile Met Asp Asn Ala Tyr Phe Cys Glu Ala Asp Ala Lys Lys Cys Ile 
    530                 535                 540                 


Pro Val Ala Pro His Ile Lys Val Glu Ser His Ile Glu Pro Ser Phe 
545                 550                 555                 560 


Asn Gln Glu Asp Ile Tyr Ile Thr Thr Glu Ser Leu Thr Thr Thr Ala 
                565                 570                 575     


Gly Arg Pro Gly Thr Thr Glu His Ile Pro Gly Ser Glu Met Pro Val 
            580                 585                 590         


Pro Asp Tyr Thr Ser Ile His Ile Val Gln Ser Pro Gln Gly Leu Ile 
        595                 600                 605             


Leu Asn Ala Thr Ala Leu Pro Leu Pro Gly Lys Glu Phe Leu Ser Ser 
    610                 615                 620                 


Cys Gly Tyr Val Ser Thr Asp Gln Leu Asn Lys Ile Met 
625                 630                 635         


<210>  142
<211>  1323
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  142
gaggtgcagc tggtggaatc tggcggcgga ctggtgaaac ctggcggcag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc gacgcctgga tggactgggt gcgccaggcc      120

cctggcaagg gactggaatg ggtggccgag atcagaagca aggccaacta tcacgccacc      180

tactacgccg agagcgtgaa gggccggttc accatcagcc gggacgacag caagaacacc      240

ctgtacctgc agatgaacag cctgaaaacc gaggacaccg ccgtgtacta ctgcaccctg      300

attagagact actggggcca gggcaccctg gtcaccgtct cctcagcctc caccaagggc      360

ccatcggtct tccccctggc gccctgctcc aggagcacct ccgagagcac agcggccctg      420

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgct      480

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc      540

agcagcgtag tgaccgtgcc ctccagcaac ttcggcaccc agacctacac ctgcaacgta      600

gatcacaagc ccagcaacac caaggtggac aagacagttg agcgcaaatg ttgtgtcgag      660

tgcccaccgt gcccagcacc acctgtggca ggaccgtcag tcttcctctt ccccccaaaa      720

cccaaggaca ccctcatgat ctcccggacc cctgaggtca cgtgcgtggt ggtggacgtg      780

agccacgaag accccgaggt ccagttcaac tggtacgtgg acggcgtgga ggtgcataat      840

gccaagacaa agccacggga ggagcagttc aacagcacgt tccgtgtggt cagcgtcctc      900

accgtcgtgc accaggactg gctgaacggc aaggagtaca agtgcaaggt ctccaacaaa      960

ggcctcccat cctccatcga gaaaaccatc tccaaaacca aagggcagcc ccgagaacca     1020

caggtgtaca ccctgccccc atcccgggag gagatgacca agaaccaggt cagcctgacc     1080

tgcctggtca aaggcttcta ccccagcgac atcgccgtgg agtgggagag caatgggcag     1140

ccggagaaca actacaagac cacacctccc atgctggact ccgacggctc cttcttcctc     1200

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1260

gtgatgcatg aggctctgca caaccactac acacagaaga gcctctccct gtctccgggt     1320

aaa                                                                   1323


<210>  143
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity  matured antibody sequence

<400>  143
gagatcgtgc tgacccagag ccccggcacc ctgtctctga gccctggcga gagagccacc       60

ctgagctgta ccgccaccag cagcgtgtcc agcagctacc tgaattggta tcagcagaag      120

cccggccagg cccccagact gctgatctac agcaccagca acctggccag cggcatcccc      180

gacagattca gcggcagcgg ctccggcacc gacttcaccc tgaccatcag ccggctggaa      240

cccgaggact tcgccgtgta ctactgccac cagtaccaca gaagcacccc caccttcggc      300

ggaggcacca aggtggagat caaacgaact gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645


<210>  144
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide linker

<400>  144

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  145
<211>  205
<212>  PRT
<213>  Macaca fascicularis

<400>  145

Glu Pro Lys Phe Thr Lys Cys Arg Ser Pro Glu Arg Glu Thr Phe Ser 
1               5                   10                  15      


Cys His Trp Thr Asp Ala Val His His Gly Leu Lys Ser Leu Gly Pro 
            20                  25                  30          


Ile Gln Leu Phe Tyr Thr Arg Arg Asn Ile Gln Glu Gln Thr Gln Glu 
        35                  40                  45              


Trp Lys Glu Cys Pro Asp Tyr Val Ser Ala Gly Glu Asn Ser Cys Tyr 
    50                  55                  60                  


Phe Asn Ser Ser Phe Thr Ser Val Trp Ile Pro Tyr Cys Ile Lys Leu 
65                  70                  75                  80  


Thr Ser Asn Gly Asp Thr Val Asp Gly Lys Cys Phe Ser Val Asp Glu 
                85                  90                  95      


Ile Val Gln Pro Asp Pro Pro Ile Ala Leu Asn Trp Thr Leu Leu Asn 
            100                 105                 110         


Val Ser Leu Thr Gly Ile His Ala Asp Ile Gln Val Arg Trp Glu Ala 
        115                 120                 125             


Pro Pro Asn Ala Asp Ile Gln Lys Gly Trp Met Val Leu Glu Tyr Glu 
    130                 135                 140                 


Leu Gln Tyr Lys Glu Val Asn Glu Thr Lys Trp Lys Met Met Asp Pro 
145                 150                 155                 160 


Ile Leu Ser Thr Ser Val Pro Val Tyr Ser Leu Lys Val Asp Lys Glu 
                165                 170                 175     


Tyr Glu Val Arg Val Arg Ser Lys Arg Arg Asn Ser Arg Asn Tyr Gly 
            180                 185                 190         


Glu Phe Ser Glu Val Leu Tyr Val Thr Leu Pro Gln Met 
        195                 200                 205 


<210>  146
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized and/or affinity matured antibody sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa can be T, R, or E

<400>  146

Xaa Ala Thr Ser Ser Val Ser Ser Ser Tyr Leu His 
1               5                   10          


