                         SEQUENCE LISTING

<110>  Novo Nordisk A/S
       Odegard, Valerie
 
<120>  ANTI-CRAC CHANNEL ANTIBODIES

<130>  8338.204-WO

<160>  60    

<170>  PatentIn version 3.5

<210>  1
<211>  301
<212>  PRT
<213>  Homo sapiens

<400>  1

Met His Pro Glu Pro Ala Pro Pro Pro Ser Arg Ser Ser Pro Glu Leu 
1               5                   10                  15      


Pro Pro Ser Gly Gly Ser Thr Thr Ser Gly Ser Arg Arg Ser Arg Arg 
            20                  25                  30          


Arg Ser Gly Asp Gly Glu Pro Pro Gly Ala Pro Pro Pro Pro Pro Ser 
        35                  40                  45              


Ala Val Thr Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu Val Met 
    50                  55                  60                  


Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys Leu Tyr 
65                  70                  75                  80  


Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala Leu Leu 
                85                  90                  95      


Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp Ala Asp 
            100                 105                 110         


His Asp Tyr Pro Pro Gly Leu Leu Ile Ala Phe Ser Ala Cys Thr Thr 
        115                 120                 125             


Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr Cys Ile 
    130                 135                 140                 


Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn Ser Val 
145                 150                 155                 160 


Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu Ala Trp 
                165                 170                 175     


Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu Val Val 
            180                 185                 190         


Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Lys Gln Pro Gly Gln 
        195                 200                 205             


Pro Arg Pro Thr Ser Lys Pro Pro Ala Ser Gly Ala Ala Ala Asn Val 
    210                 215                 220                 


Ser Thr Ser Gly Ile Thr Pro Gly Gln Ala Ala Ala Ile Ala Ser Thr 
225                 230                 235                 240 


Thr Ile Met Val Pro Phe Gly Leu Ile Phe Ile Val Phe Ala Val His 
                245                 250                 255     


Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln Phe Gln Glu 
            260                 265                 270         


Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln Leu Asp His 
        275                 280                 285             


Arg Gly Asp His Pro Leu Thr Pro Gly Ser His Tyr Ala 
    290                 295                 300     


<210>  2
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  2

Glu Val Gln Leu Asp Ala Asp His Asp Tyr Pro Pro Gly Cys 
1               5                   10                  


<210>  3
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  3

Trp Val Lys Phe Leu Pro Leu Lys Lys Gln Pro Gly Gln Pro Arg Pro 
1               5                   10                  15      


Thr Ser Lys Pro Pro Ala Ser Gly Ala Ala Ala Asn Val Ser Thr Ser 
            20                  25                  30          


Gly Ile Thr Pro Gly Gln Ala Cys 
        35                  40  


<210>  4
<211>  22459
<212>  DNA
<213>  Homo sapiens

<400>  4
gttggaatta taagcatgag ccaccacacc tggcccatga ttcatttatt tatttagttg       60

ttttttcttt gagacaggat ctcgctttat tgcctaggtt ggaggacagt ggtgtgatca      120

ccgcagcttc attccaagaa gctgggagta caggctcacg ccaccacatc tggtttattt      180

atttatttat tgagacagag tattgctttt attgcccagg ctggagtgca atggcataat      240

ctcatctcat cgcaaactcc acctcccggg ttcaggcggt tctcctgcct tagcctccca      300

agtagctggg attacaggca tgcgccacca caccagctaa tttttgtatt tttagtagag      360

acgaggtttc tccatgttgg tcaggctggt cttgaactcc tgtcctctca ggtgatccgc      420

ccacctcagc ctcccaaagt gctgggatta caggtgtgag ccaccgtgcc tagtcttatt      480

tatttattta tttggagaca gagtctcgct ctgtcgccca ggctggagtg cagtggcacc      540

atcttggctt actgcaagct ccgcctcccg ggttcacgcc attctcctgc ctcagcctcc      600

caagtagctg ggactacagg cgcccgccac cacacccagc taattttttt gtatttttag      660

tagagacggg gtttcaccgt gttagccagg atggtctcaa tctcctgacc tcgcgatccg      720

ccggtttcag cctcccaaag tgctgggatt ataggtgtga gccaccgcgc ctggcctttt      780

tttttttttt tttttttaag tagagatgtg ctactgcact ccagcctggg tgactattga      840

gaccctgtct caataaataa ataaataaat aaataaataa ataaataaat aaataaggcc      900

aggcgcagtg gctcacatct gtaatcccag cactctggga ggctgaggca ggcagatcat      960

ctgagttcag gagttcgaga ctagcctgga caacatggtg aaaccctgtc tctactaaaa     1020

atataaaaaa ttagctgggt gtgctggtgg gcacctgtaa tcctagttac tcaggaggct     1080

gaggcagaag aatcgcttga acctaggaat tggaggttgc agtgagctga gattgagcca     1140

ctacgctcta gcctggggga cagagcgaga ctccatctta aaaataataa aaataaaaat     1200

aaaataaaat gtttaaatac gttgggcaca atggtttaca cctgtaatcc cagcactttg     1260

ggaggctgag atgggtggat cacttgaggt caggagttcg agaccagcct ggccaacatg     1320

gtgaaaccct gactctacta aaaatacaaa aaattagctg ggtgtggtga tggacacctg     1380

taatcccagt tatttaggag gctgagccag aataatcggt tgaacccagg aggcggaggt     1440

tgcagtgagc cgagatcgag ccactgcact gcagcctggg gaacagagag agactctgtc     1500

ctaaaataat aataaaataa aataaaatgt ttgaataggc tggacacagt ggctcatgct     1560

tgtaattcca gaactttggg aggcccagat gggaggatcc cttgagccca ggagtttgag     1620

accagcatgc tcaacatggg gagacgctgt cactattatt ttttattgga gacggagtct     1680

ccctctgtcg cccaggcttg agtgcagcag cctgatctca gctcactgca acctctgcct     1740

cctgcgttca agcaattatc ctacctcagc ttccccagtt gctaggatta taggcgtgcc     1800

ccatcatacc tggctaattt tttttgtatt tttagtagag atgggggttt caccatgtta     1860

gccaggctgg tctcgaactc ctgaccttag gtgatccacc cgcttgggcc ttccaaagtg     1920

ttgggataac aggtgtgagc caccgcgcct ggccacactt tttttttttt ttaatgctta     1980

aacagatgaa caggtcaact aaataagcta gatgatttca gatgctgtag tgatcacagc     2040

tataaaggga agaaatcagg atgaggtgac agattgtgac accggggcta cttcaataga     2100

gggaaggtct ctcaggaggt gctatttgag ctgagacaca aatgttgagt gaaaggggta     2160

agaagtacaa aggcgggcca tggcgcggtg cgtcacgcct gtaatcccag cactttggga     2220

ggctgaggcg ggtggatcac caggtcaaga gatcgagacc atcctggtcc atatggtgaa     2280

accccgtctc tactaaaaat accaaaaata gctgggcgtg gtggcgcgcg cctgtagtcc     2340

cagctactcg gcaggctgaa gcaggagaat tgcttgaacc cgggaggcgg aggttgcagt     2400

gagccgagat cgctccactg cactccagcc tggtgacaga gtgagactcc gtctcaaaaa     2460

aaaaaaaaaa aaagtacaaa ggccaccagg gaaacaaagc cagtagggtg agatttcaaa     2520

ttccaaattc cccaattttt tttttttttt ttgagaggga ctctcgctct gtcgctcagg     2580

ctggagtgca gtggctcgat ctcggctcac tgcaagctcc gcctcccaag ttcaaacgat     2640

tctcctgcct cagcctccct ggtaactggg actagggagt cacctgacta atttttttag     2700

tagagacagg gtttcaccat gttggctagg ctggtctgga actactgacc ttgtgatctg     2760

cctgcctcgg cctcccaaag tgttgggatt ataggcgtga gtcaccgcgc ccggccccca     2820

tctttatttt aaaaaagcca agaaaaggac aaaaaaccaa acaccgcatg ttctcactca     2880

taggtgggaa ttgaacaatg agaacacatg gacacaggaa ggggaacatc acactccggg     2940

gactgttgtg gggtggggaa aggggggagg gatagcatta ggagatatac ctaatgctaa     3000

atgacgagtt aatgggtgca gcacaccaac atggcacatg tatacatatg taactaacct     3060

gcacattgtg cacatgtacc ctaaaactta aagtataata ataataaaat taaattttaa     3120

aaaaaaagcc aagaaagggc tctgcgggaa ccagagactt cttgggggca gaggttttca     3180

tcccacaacg gttgggtggg ggcgcgccct ctagtggtga caagagttac gtttcacccc     3240

gccaaccggc aatgtcacat gctcgtcact cattcctgtc tctcccatag ttattcattc     3300

aacaaaaaat tactgaggac cgattgtatg ccgaggaata ttctagatgc tgagggtaga     3360

gctgtgaagc tgatagtaaa ggtccctgcc ccggagttta cctcctagga gacattccct     3420

agcacagtcc tgcatacacc cccacctcac ctctgctccc caaaattggc cttccaacgc     3480

tccaacagcc aaatatccct gcttaaaggt cttggcatga gcagttccct cgccgtcctg     3540

gaaagctaga tcctgtctgt ttgcatggcg ggctctggtc tcagcttaaa tgtgacctaa     3600

gtcagaaagg tgtgatctca cttatttcct gcccctctcc acactccact aaaatataat     3660

attcgggccg ggcatggagg ctcatgcctg taatcgcagc actttgtgag gccgaggcgg     3720

gcggatctcc tgacgtcagg agttccaggc tagcctggcc aacatggcaa aaccccgtct     3780

ctactaaaaa tacaaaaatt agccaggtgt ggtggcgggc gcctgtaatc ccagctacgc     3840

agcaggctga ggcaggagaa tcgcttgaac cgggaggtgg aggttgcagt gagccaagat     3900

cgcgccattg cactcctcca gcctgggcga caagagcaaa accctgtctc aaaaaaaaaa     3960

aaaaaaaaaa aatatatata tatatatata tatatatata tatacacaca cacacacata     4020

tatatacata tatatgtgta tatatgtgtg tgtgtatata tatatataaa atattcaatg     4080

aaggttatca ttttcctgga atccctcagc gtagcacgta atagttgctc agaagacact     4140

tgctgaatag gtttgaagat tcactggttt aaaaaatatc aggtggccgg gcacggtggc     4200

tcacgcttgt aatcccagca ctctgggagg ccgaggcggg cggatcacaa ggtcaggagt     4260

ttgagaccag cctggccaat atggtgaaac cccatctcta ctaaaaatac aaaaattagc     4320

agggcatggt ggcgggagcc tgtaatccta gctactcggg aggctgaggc aggagaattg     4380

cttgaaccca gtaataaaaa aataataaat caggaaccgg tcacctcaat acgtatcaga     4440

tgctggtgaa cacaggtgga caaagtggtt aacagacagg ttttgtccat ctcgttcacc     4500

accctaccca gcctcagcac ctagaccagt gttggcaccc agtgggcgcc aaataaacac     4560

tgcttgaact ccagacgtca gccgctcttt ttcctacaga ccttgagcca ccttgttcca     4620

aaggggatat gggcctcagg aggcgcccag aggtgacctc aggcggcccg acccaggagt     4680

ccaagctcca ggagcagggc cacgggagca gctgcggaga ggggcggcgc caggagccgg     4740

agcgggcagc cgggcgcttc caggaaaagt ggcgggcggc ggcgcgccag ggaccgtggg     4800

cggtgccgtc ggagcgggcg ggtcacgtga cgcccacaac aacgcccact tcttggtggg     4860

cggggcacag gtgggcgggg agcatgcaaa acagcccagg gcggcggcca atcgcggcgc     4920

gcgccggggg tccaggcccc ggggatccga ggcgccgccc gcgcgcagtc tctggtcact     4980

gccgcccggg ggcttttgcc agcggcgccg cgggcctgcg tgctggggca gcgggcactt     5040

cttcgacctc gtcctcctcg tcctgtgcgg ccggccgggt gaggccgggc ccgcgtaggg     5100

ggcagtcggc ggctgcctcc ggcggaggtg cctcgcggcg cccgggccgg cccgcgcctc     5160

ggcggcgtgc tccatgcatc cggagcccgc cccgcccccg agccgcagca gtcccgagct     5220

tcccccaagc ggcggcagca ccaccagcgg cagccgccgg agccgccgcc gcagcgggga     5280

cggggagccc ccgggggccc cgccaccgcc gccgtccgcc gtcacctacc cggactggat     5340

cggccagagt tactccgagg tgatgagcct caacgagcac tccatgcagg cgctgtcctg     5400

gcgcaagctc tacttgagcc gcgccaagct taaagcctcc agccggacct cggctctgct     5460

ctccggcttc gccatggtga gctccggccg ccctgccctg ccccctctac tgtcccggct     5520

gctcccgccc gcagccccga cggggctctc tgggcgggcc gggcgggcca gagtgagggg     5580

aagagctggg agaaaccgtg gtgagcgctg cgcggggggc agaggtgctg gacgtgagca     5640

ctggtgggcg ccgagtactc cgatctgggg tggtgacaag ccatatcaga gtccgggctc     5700

ggggtgcttg ggtgcctcca catggccatg cctgccccag caagagtggt agatgcatcc     5760

cgaagttagc tctgtaagaa gcccgcccca tgtgcgttca ggagcgaaag gagggactca     5820

gaagctctaa cccagctggg ggcgtcagga ggtggggaca aggagaaaga ccttgcgctg     5880

tcttgtgccc cggcacccga ggccggaagt tgttagccgt gttcttttat cagctcctag     5940

aggggatttc ctgacacccc ttttccaccg cattttccga gagcctcagc ctgggggttt     6000

gacaaccagt ccccctcagt tttttctcca gaaacttgcc actgagtcac tgcgtgtgag     6060

ggaggaggga gggacatgtt cccgttgaat gggctcttta ttttttattt gttccaagac     6120

ggagtctcgc tctgtcgccc aggctggagt gcagtggtgc aatctcggct cactgaaatt     6180

tccacctcct gagttcaagc gattctcatg cctcagcctc ccgagtagct gggattacag     6240

gctcgcgcca ccacgcccgg ctaatttttg tgttcttagt agagacgggg tttcaccctg     6300

ttggccaggc tgatctttaa ctctcgacct cgtgatctgc caaatctcgg cctcccaaag     6360

tgctgggatt acaggcgtga gctaccacac ccggcccaat gggctctttc ttgatctagg     6420

gcataggcat gctttccttt ccccaccatc ccaaagagct ggagtgcaaa gcctctgagg     6480

tgtggggtgg gtgaggctgc ggatgggcct gagaagtggc tctggggata ccctcaggct     6540

tggcatattg aagtttctcc gttgcagggg actacataat aactacatta ttaccactcg     6600

gtgatatcag cctgccatga atggactctg ctccccgccc ctcagttctg tagaccagag     6660

cactcctgcc cccgccacca gtgagctaag cccttggcct tgagggaggg agtggctgca     6720

cccttcgtgt tttcttggga agggagtgtg tctgaaactc tccctgcttt gccttgcagc     6780

agagcctgaa ttttttaagg cccagagcac gctgggccac agtggaaagg ccgggagatg     6840

gggagtggga agcagccttc cctgctcagt tacttgctgc ctgtgtgacc tcaagcaact     6900

cactctccct gtccgggcct caattcctga attgatcaaa gaaggctgct actcaaaagt     6960

ttctctgact ttgagaataa aattgaggga gcccctgaaa ggagatcagg gagtgtgttt     7020

gcataaacag acggcactct catttttagt ttagacagga cggacttctg ctctgttaat     7080

ttcaaatcct aagagaccag gttctgcctg ctgcctgaag aatctctaaa agcagctggc     7140

atttactgaa cactcactca gtgctaggtg ccttaactcc tgggcttact caacaaccct     7200

ctgtggtgat tttgtcaaag ggctctccca agaccgcaca gccagtctgg tggagcggga     7260

tttgaaccca gctctgctgg tgttcagaac ttgctcaggc acttgtaccc attgcggtgt     7320

ataggaactc tgattgatgt ccagccaggg atgtgttagg acactaggaa atgagaaata     7380

gggcaaaaga gtttcttttt tttttttttt ttttttgaga cggagtcttg ctctgtcacc     7440

caggctggag tgcagtggtg cgatcttggc tcactgcaag ctctgactcc tgggttcacg     7500

ccattctgct gcctcagcct ctggagtagc tgggactaca ggcgcccaca accacgcctg     7560

gctaattttt tttgtatttt tttagtagag acggggtttc accgtgttag cgaggatcgt     7620

ctcgatctcc tgacctcatg atccacccgc ctcggcctcc caaagtgctg ggattagagg     7680

cgtgagccac cggcgcccgg ccgcaaaaga gtttctttta agccaaagaa agttttataa     7740

ttggtggtgg ggagggagct accagttgtc agcttttccc tgcagcgctt ggtatttaag     7800

ataatggttc ccccttttct tgtggtcatg agtttatagc tgccccaggc tccttctcac     7860

tcctgagggg tgagatccag atgaatgaca ctttcctgcc ttctcaagtc ccttcttcct     7920

ttcgaagaca ggcctcatgg tcaaatgtca cctccttctc ttgctaaaaa cagtgtgggg     7980

aagtcaggag actggggcag ccagtggcat ggagtgggcc ttggcccacc cagtctgtct     8040

cttggggact tttattttcc cccacctggg tggagaaggc ttcctggcac tactgatgga     8100

atccccaaag ttctgcaggc agggaaggac cgaaccccat gatactctcc attctgcagt     8160

tacaagaagg taactgcatg tgccatgaag ttggaaatct ataggaggga tgggattggg     8220

tgcagggtct gaccatgccc cactcccact tagacaccca gcctgtaagt gagcttggga     8280

gaggagaggg tgccagcagc cccaacgcca tggtaacaga gtgacaagtt tcctggatta     8340

ctctcccttg gcttatgagt cagcacaacc aacttcctgc ccccagaggg cttccttccc     8400

agagacctgg aaagtcagag gagctgactt gacctttgat tgccaaggga tggggtcaac     8460

caggtgagat tgagggaggg tctcccacaa atcctggagg ggattgagag gttccccact     8520

tcatgggtag aacagcctgg ccaggtggcc gggaagtgtt ggggatggct ggtgggtgac     8580

ctcaggcaag aggctttact tctttgaagc cagttttctt ttcttttctt ttcttttttt     8640

ttgagacgga gtttcctctt tgttgcccag gctggagtgc agtagcacaa tctcagctca     8700

ctgcaacctc cacctcccag gttcaagcga ttctcctgcc tcagcctccc gaatagctgg     8760

gattacaggc acacaccacc tcacctggct aatttttgta tttttagtag agacggggtt     8820

tcaccatgtt ggccagggtg gtctcaaact cctgatctca ggtgatccac ccgcctcggc     8880

ctcccaaagt gctgggatta caggtgtgag ccaccatgcc tggctgaagc cagtttttta     8940

atgtgtatgg agatggcagg tatcctgctc tcccatggac tcatatgaag gttcattatg     9000

aggccagact gggcccatga aacacaggaa ttttcagggt ctgatgatgc acaccttgcc     9060

cggaccctct ctgatctgca gatgagattc ttgctccaca cggcagttct aggaacagca     9120

ggcctcaggc gcaccatcct ccaaactcta atgagagata caaagcaagg gggcctggat     9180

atagcatagg atcagcatcc cgtagagctc cttaagccca gagtactctt gtgggctttg     9240

attcaggtcc tctgtgcctc agtttatact tcattgagag gcagccagcc tcagcctgac     9300

cccgtcccct gcaggactgg cgagcatatg tggtgatctt gtctgctggg gaaggcaggc     9360

tgtaacatta gcctgagctg aagataattg ggaaggtcag tctgctgccg taaacaaaat     9420

gctttccatg acctgggatc aattattttt ggattatctg cctcctcagt tctctgcccg     9480

ccagcaccct tttgttccca agttctagag ctggttcaga agtttcctgt aatttctatg     9540

aaaatgagtt ggaaggaacg actcaagtca taagacactg agcctctgtg acgtgttcag     9600

agttcaggga ccatgtaaat gagcaagaaa ttgctattac tattcctagt actgatcact     9660

gatagtaatt attattgctg ttgttgattg ggctcttgca ataggctaga tggtgcccca     9720

cgtagcatct tgtgtgatcc tcctataaac caggtgagta taggtgatgg tcattgagag     9780

gaaagacttg cgcatggtca cctggctggg aagctgcaga gccctgtggc tgtggtgtag     9840

cgccattgct gtgggagaga aagcatcaga gagtgtaggg gaacagagct gagaagctca     9900

agcagggtaa ggtcagaaca gacacttgag caagacaact tggttcaaat cccagctcta     9960

cctcttataa gggcaagacc ttaggcaagt catttaacct ttctgggcct cagtttcttc    10020

atctttaaaa tggagtacgg ccgggcgcat tggctcacgc ttgtaatccc agcactttgg    10080

gaggccgaag tgggcgaatc acctgaggtc aggagttcaa gaccagcctg gccaacatgg    10140

tgaaacccca tctctactaa aaatacaaaa attagccggg tgtagttgtg catacctgta    10200

attccagcta ctcgggaggc tgaggcagaa gaattgcttg aacctgggag gcggaggttg    10260

caatgagcag aggttgcacc actgcactcc agcctgggca acagagtgag actccatctc    10320

aaaaaaaaaa aaaaaaaaaa tttttgcaga gcacttacag tatctgaccc gagtatccca    10380

gaaacttgct tacccttttt tccattgtgt tagggctgct aagggttaac tgagaagaat    10440

ctggttcttg ccgagccttg agtgtggtgg agttaggact tgagaaagcc ttcaagtcaa    10500

aggaaatggc aggaacagtt aaagaagaga aattacaggg cctaggggaa aggtacaggg    10560

gctgtggttg gggttgaggg tcttcaggaa gtagtagaga acggtgaatt tagccaggca    10620

agatgatgga gggccttgat tgggtgggaa atttgaactc ttggataggc aacagggagc    10680

cattgaaggt tttagacagg agttacatga tgaattctat gatgacggtg gtggtggttg    10740

tgattactgt ttactgaaac cctgttgtgc caggcatgag cctgaacgct tttctttcat    10800

tcttactgaa tcctcaccat agctcttaaa agtatgtact gtaaacagga aaactaaggc    10860

tcctagaagt taagattctc cagctagtag aattccagct ctggtctttc tggctgggag    10920

ccagttgaag agaaagtctg ggtctgtgtc ccgctgaccc tgtatgcaaa ttcagcctat    10980

tcatggcttg taacaaattt actaagttgc aaccaacaca ttttgttgtt tctttctttt    11040

gataactttg gtaccaagct cctggtcctt tttagaatga gataagggtg aaatgaaaca    11100

aagtcgcagc acgcattgca tcttgcaaga ccttactgat gtgctgtaag gctaaatgtt    11160

gattggttaa acttttgttt ctgttataaa cgcgtgtgtg tctatttata gaaacatttg    11220

gagtcctgga ctgtcatggt caagactttg taaaccactg cacactaggc ctcaataccc    11280

tcttaagaga tggtttgcat ttgaggtggg gccggcaggc tcagacagct ccgggtgacc    11340

ctgcatggtt gcggcctaga gggcctcatg ttccaggctg cagccaccca ccctcctaaa    11400

agggtggaca agaaaagaac taggccaggg gaaggaaggc tgtgggacct gaggtcaggc    11460

ccagcatggg agggctgcct cagagggcct ggacttgcag gcgccaggtg cccagggtct    11520

ccatggagcc cagcaggagc caggagagat agctggcaat caggcgaggt gggctgacgg    11580

ctggtatggt ccgtcagggc cagccaggcc ttgcccttcg cagaattatg taaccctctt    11640

cttggccctt gctaaggttt ggcatctcta gccaaaaccc tattgggggg atccatggac    11700

cagtgtgagg tggagctggt ggtcttttgc ctttcctatc ccttataggg cttgcctcgc    11760

caggttcagg cggccagtgg ctggcggggg gctgtttatt ttgggctgac gggctatatt    11820

taccttgtga agctgcgtgc gatctgatct gatccaatct tgctggggct cagctggggc    11880

tctggcagtc agctgccaga tctgtagggc ccctggccct ccccctgcca cccaagggga    11940

gatttccaga gcaggaagta tcctggaaaa agtggtggca tttattcctg tgactttttc    12000

atcaagctcc atgacacatg ccaaccgttc ctttcttctc actttttttt ttcccagttg    12060

caagatttta ttaaaatttt ttttgtttgt ttcttagaac tttatttatt tatttattta    12120

tttatttatt tatttattga tcattcttgg gtgtttctcg cagaggggga tttggcaggg    12180

tcatgggaca atagtggagg gaaggtcagc agataaacaa gtgaacaaag gtctctggtt    12240

ttcctaggca gaggaccctg cggccttccg cagtgtttgt gtccctgggt acttgagatt    12300

agggagtggt gatgactctt aacgagcatg ctgccttcaa gcatctgttt aacaaagcac    12360

atcttgcacc gcccttaatc cgtttaaccc tgagtggaca cagcacatgt ttcagagagc    12420

acagggttgg gggtaaggtc acagatcaac aggatcccaa ggcagaagaa tttttcttag    12480

tacagaacaa aatgaaaagt ctcccacgtc tacctctttc tacacagaca cggcaatcat    12540

ccgatttctc aatcttttcc ccacctttcc cgcctttcta ttccacaaaa ccgccattgt    12600

catcatggcc cgttctcaat gagctgttgg gtacacctcc cagacggggt ggtggccggg    12660

cagaggggct cctcacttcc cagtaggggc ggccaggcag aggcgccccg cacctcccgg    12720

acggggcggc tggccgggca gaggctgcaa tctcggcact ttgggaggcc aaggcaggcg    12780

gctgggaggt ggatgttgta gcgagccgag atcacgccac tgcactccag cctgggcacc    12840

attgagcact gagtgaagga gactccgtct gcaatcccgg cacctcggga ggccgaggct    12900

ggcggatcac tcgcggttag gagctggaga ccagcccggc caacacagcg aaaccccgtc    12960

tccacccaaa agatacgaaa accagtcagg cgtggcggcg cacgcctgca atcgcaggca    13020

ctcggcaggc tgaggcagga gaatcaggca gggaggctgc agtgagctga gatggcagca    13080

gtacagtcca gcttcggctc ggcatcagag ggagactgtg gaaagagagg gagagggaga    13140

ctgtggggag agggaggggg agggagaggg agagggagag ggcctttctt ctcactttga    13200

atcattcttt tacacggccc cctgaaccct gtggcattga acttggttcc aagtgtgggc    13260

acatacagcc tgcctaagtg gacggagttc caggaatcgt agggtctggt gagggtaatg    13320

ggctttcttc cggagcaggg cagcaggccc tttcctcttc ctcggagagc ccagcctctc    13380

ccctctcccc agcccaaaac ctcagggctg gcgagtgtgg gtgtccccgg gccgtgtgcg    13440

tcccaacagc tgcactgctt tctggccctg gagcctgtgg gtgtgacaaa tggtgtggaa    13500

tgtggtggtc tctgtcctgt ggaggtggcc atcaggccag gtgtggcgtg gggtacacat    13560

ccttgtggcc gaggtttgga gctggagctg cctctaaata tagcaagcga ggccccgagt    13620

cggggttgga aggtgggtat gtggggtccc tgtctccagt ctgagctgag ggtatccagg    13680

cactatttct cttccatcca cttcaagctc tgtttttctc cttttttctt ttcttttctt    13740

ttttttagag atagagtcct gctctgttgc ccaggttgta gtgcagtgat gggatcatag    13800

ctcactgcag ccttgaactc ctgggctcaa gggatcctcc tgccttagcc tctcaagtag    13860

ctgggactgg ccaggtgcgg tggctcacac ctgtaatccc agcactttgt gaggctgagg    13920

tggggagatc atctgaggtc gggagttcaa gaccagcctg agcaacaagg tgaaaccccg    13980

tctctactaa aaatacaaaa gttagctggg catagtggcg ggcgcctgta atcccagcta    14040

ctcaggaggc tgaggcagga gaatcgcttg aacccgggag ggggaggttg cagtgagcca    14100

aattgtgcca gcgcactcca gcctgggtga cagagtgaga ctccatctca aaaaacaaaa    14160

agtagctggg gctacagtca tgcccactat atccagctaa tttttttttc tttgtgtgtg    14220

tgtgtgtgtc tgtgtgtgtg tgtgagatag ggtctcactt tgttgcccag gctggggtgc    14280

agtagcgcaa tcacggctca ttgtagcctc aacctcctgg gctcaaggga ttctctcacc    14340

tcagccttct gagtagctag gactacaggt atactcacta cacccagcta attttttgat    14400

tttgtagaga tgaggtctca ctgtgttgcc cagggagatc tcgaattcct ggactcaagt    14460

gatcctccta catcagctcc ctaaattgct ggattacagg tgtgtgcctg ctttatgtgt    14520

ttttctttct ttctttcttt cttttttttt tttttttttt ttttagacag agtttcgctc    14580

ttgttgccct ggctggagtg caatggcgcg atcttggttc actgcaacct ccacctcctg    14640

ggttcaagcg attctcctgc ctcagcctcc tgagcagctg ggactatagg cacgcattac    14700

cacgcccagc taatttttgt atttttagta gagacggggt ttcaccatat tggccaggct    14760

ggtctcgagc tcttgacctc gtgatccacc cacctcggcc tcccaaagtg ctgggattgc    14820

atacgtgagc caccgcgccc ggccctgtgt ttttcttttt aaccaagatt tattgagctg    14880

ctgtagctgg ccctatgcta aacatctaca tatgaaaact acatttaatc tcagccacca    14940

tgtgagggag gtgctccttt gcccccttca tacccgggct gtggagccaa gtggacttgg    15000

ttttgaatcc agcagcagag taaccctttg gacagctgac atcacctttc tgagcctcag    15060

tttcctcgtt tgtaaaagaa gaataatggt attagtaact cgtgggattc tctttttttt    15120

tttttttttt gagacagacc atgctctgtc accaagactg gagtgtagtg gcactatctt    15180

ggctcactgc aacctctgcc tcccgggttc aagcgattct cctgcctcag cctcccaatt    15240

agctgggatt acaggtgccc accaccacac cccagctaat tttttttttt tttttgagat    15300

ggagtctcac tctgttgccc acaccggagt atagtggcat gatttcggtt cactgcaacc    15360

tccatgtcca ggttcaagcg attctcatgg ctcagcctcc caattttctg ggattacagg    15420

tgtgtgccac cacactcagc taattttttt gtattttaag tagaggcagg gtgtcaccat    15480

gttggcccgg ctgatcttga actcctaacc tcaagttatc tgcctgcttc ggcctcccaa    15540

agtgctggga ttacaggcat gagccaccac acctggccca cccctgacta atttttgtat    15600

ttttagtaga gacagggttt caccatgttg gccaggctgg tcttgaactc ctggcctcaa    15660

gtgatccacc ctcctcagct tcccagtgtg ctgggattac aggcatgagc cactgcccct    15720

gtcagcctct attttatagg tgtggaagct gtggcacaga gaggttgaga tccttatcca    15780

aggtcaacag ctttgtaagt ggaggagcca gtttgcagcc agctgtgtgg tttgttctgt    15840

ggtcctgact gcatagaggg ggagagacac tacctcgggg gtggctgggg cacaggcgag    15900

gcaccaagta gggagcagaa tgggactgca gacctgtata caggcccccc atacacaccc    15960

cagcggccag ctcagggcct gagccaccta aaggctccag acgtttccag tgagtggatc    16020

agtagcagtg gacctggggc agctcagcaa cagccgctgc tgcttgtcct gtcttgggtt    16080

tcaggttccg gggtggcagg ccagagcagg aagaggaagt gctgggggtg gggaggtggc    16140

aggagacact ggctgctgga gggggctccc ctcttccagg tgtaggcagg cctgggggca    16200

gagacaaggg agctgcagga tgtggccctc catctgccgt gccctggtga cctaccccac    16260

gtcttgtgtc cagcacccac atgtgctgag ataccctcac ccgcatggac tcagaattct    16320

cagggctggc tttcggccac caaagatctt aaacacggta gaaatcctga tggcattgcc    16380

ccaaatttat atgagcttga aatgttttgt aaacgcctgg actgagaagt acatactgcc    16440

atccactgtg ggcattctta gacaaaagcc tgtgaatcct gttgaaattg tcagaaaagt    16500

cctgtgaata aatgatactt ggctgtttta aggagagtgt ccaccatctt cagattctca    16560

gagatgtccg accccaagtc agatccagat tgtgaccttc atctcgctgc agcccctttt    16620

tttatgggtg ttgaggaggg tcttggccaa ggttaccggt aaacaggcag ttaaggagct    16680

ggaacatggg tttgccagtt tggcctggcg ttctttatgc ctgagtgtgc ccctctggag    16740

gatgttgtaa agagactgtg gggtggggat gaggttccta aactgagtaa taatgaagct    16800

cacttttatt gagggtttgt tgtgtgccgg acactacctg ttttacatgg attgactctc    16860

ttaatcctca gaagaagcct tcgaggcttg tcccattatt cccattttac agatgtgaaa    16920

acagaggcac agaaagttga aagcttgcca gagtcataca gcccaatcaa gggcagggga    16980

gtcagggttc aagccaggca gactgtaaaa ggagagcggt ggggaaggaa ggagtccaca    17040

cccctaccta gggcaggagg ggtgaggaca ggaattccct gcctgctggg ggccaggcta    17100

gtgtgcggct aatggagaaa cttcaacatt aggcttgccg ctctgagcct gccacatata    17160

tagcaaacac cttataaaga gtcactgtcc ttgatggaat gactgccata ggtatccgcc    17220

atctccctac ccctgtccct ccagccctca tgggttgacc atggttgtgt gcccactgcc    17280

cgctgctcct ggcccagatc tgataagctg gctcctttgc atgggggtga cttgcaaggc    17340

ccaggtgagg agcagcgggt gtctggcccg gagcatgccc ctggtgacct cgggtccaca    17400

ggtctccagg aactgggggc agctggtgtg tcagccctgg ggctggggag gagacagccc    17460

cagggtgtac tggccaccca gcctgcacca gggctgggcc cgtcgcttct gggaagcctg    17520

ctctgtatgt caggtcgtgc gctgtgttct cagaagggcc tgagtgtgcc ctgggagggc    17580

agccaccacc cctctgcatg tccccagagc agggcatgaa ggagaagcct ctgcttgggt    17640

gtgaggatgt ggggccagca ggcatgatgg ctggcgattg ctttttttaa tgcttttatt    17700

ttaaccatag taaaatacgc ataacaaaat ttaccatttt gaccactgat ggtggtggtt    17760

ggtactaatt ttaattttat tattattatt attattatta ttattattat tattattatt    17820

attgagttag agtctcactc tattgcccag gctggagtgc agtggcacga tctcagctca    17880

ctgcaacctc cgccacccgg gttcaagtga ttctcctgcc tcagcctccc aagtagctgg    17940

gattacaggc acgtgccacc acgcccagct aatttttgta ttttcagtag agatggggtt    18000

tcaccatgtt ggccaggctg gtctccaact cctgacctca ggtgatccac ccgcctcaat    18060

ttcccaaagt gctgggatta caggcatgag ccactgggcc cggcctgatt ttattttttt    18120

tagagacaag gtcttgctct ggtgcccaga ctggagggcc atggggcagt catagctcac    18180

caccacctca aactcctggg ctccagcgat ccttccccac cagactccca agtagctaga    18240

actacaggtg tgcaccacca ccccccagct aattaaacaa atttttttta tagaggtggg    18300

gtttctctgt gttgcctggc tgctctcgaa ctcctggcct caagcagtcc tcccaccgca    18360

gcctccacaa gtattgagat tacaggcgtg agccactgtg cctgtcctgc ggctggtttc    18420

taatacctgg ctaggtggta atagcagtgt tttgggaggt ggttaccatg tgccagctct    18480

catttaattg ttaaaataat tctatgaatt ggctgggtgt ggtggctcac acatgtaatc    18540

ccaacacttt gggaggctga ggcaggcagg tgggtcacct gaggttggga gttcgagacc    18600

agcctggccg acatggtgaa accccgtctc taccaaaagt acaaaaaagt agcaaggtgt    18660

ggtggcgcat gcctgtaatc ccaggtactc gggaggctga ggcaggagga tcacttgaac    18720

ccgggagtgg aggttgcagt cagccgagat cgcatcactg ggctccagcc tgggcaaaag    18780

agcacgactc tgtttggaga aaaaaaaaaa aaaaatccta tgaactacta ttatatccct    18840

attttacgga taagaaagtc gaggctcagg ccgggcgcgg tggctcacac ctgtaatccc    18900

agcactttgg gaggctgagg cgggcggatc acgaggtcag aagatcgaga ccatcctggc    18960

taacacggtg aaaccccgtc tgctaaaaat acaaaaaatt agccgggcgt ggtggcaggc    19020

gcctgtagtc ccggctactt gggaggctga ggcaggagaa tggcgtgaac ccgggaggtg    19080

gagcttgcag tgagccgaga tcgcgacact gcactccagc ctagcttggg caacagagtg    19140

agactccctc tcaaaaaaaa agaaaagaaa agaaaatcga ggctcagaga ggttaagtga    19200

ctttcccagg gttgcacagt tagtgagtgc cagggctggg attcagatcc aggcagcctt    19260

ggctcttgct ttctgtaggg ctttctgcca ctctcatcca caagtggata ggccttacta    19320

tccccattgt agacatatga aaactgaggc tcggagaggc caagcgactg gccagggtcc    19380

cagagcctga caggaggaga gctaggactg aagagtagta gtgtgggctg ggaccgctgg    19440

cactcatcct gcctgtcccc ccgcaggtgg caatggtgga ggtgcagctg gacgctgacc    19500

acgactaccc accggggctg ctcatcgcct tcagtgcctg caccacagtg ctggtggctg    19560

tgcacctgtt tgcgctcatg atcagcacct gcatcctgcc caacatcgag gcggtgagca    19620

acgtgcacaa tctcaactcg gtcaaggagt ccccccatga gcgcatgcac cgccacatcg    19680

agctggcctg ggccttctcc accgtcatcg gcacgctgct cttcctagct gaggtggtgc    19740

tgctctgctg ggtcaagttc ttgcccctca agaagcagcc aggccagcca aggcccacca    19800

gcaagccccc cgccagtggc gcagcagcca acgtcagcac cagcggcatc accccgggcc    19860

aggcagctgc catcgcctcg accaccatca tggtgccctt cggcctgatc tttatcgtct    19920

tcgccgtcca cttctaccgc tcactggtta gccataagac tgaccgacag ttccaggagc    19980

tcaacgagct ggcggagttt gcccgcttac aggaccagct ggaccacaga ggggaccacc    20040

ccctgacgcc cggcagccac tatgcctagg cccatgtggt ctgggccctt ccagtgcttt    20100

ggccttacgc ccttcccctt gaccttgtcc tgccccagcc tcacggacag cctgcgcagg    20160

gggctgggct tcagcaaggg gcagagcatg gagggaagag gatttttata agagaaattt    20220

ctgcactttg aaactgtcct ctaagagaat aagcatttcc tgttcttcca gctccaggtc    20280

cacctcctgt tgggaggcgg tggggggcca aagtggggcc acacactcgc tgtgtcccct    20340

ctcctcccct gtgccagtgc cacctgggtg cctcctcctg tcctgtccgt ctcaacctcc    20400

ctcccgtcca gcattgagtg tgtacatgtg tgtgtgacac ataaatatac tcataaggac    20460

acctccttcc cgtgtcttgt atttgttggg cctgggctac tgctcaccct ggttaggtga    20520

gcctctagga aaacttaaaa caaattttaa gccaggtatg gtggcacata cctgtggtct    20580

cagctattca ggaggccaag gcaggaggat ctcttgagcc caggagtttg agaccccatc    20640

tcaaacaaaa aatacaaaaa ttagccagcc acggcgcctg cacttccagc tcctttgaga    20700

gactgaggca ggaagattgc ctaagcccag gaggccaagt ctgcagtgag ctatggtaac    20760

accactgcac tccaacctgg gcaacagagg gagactctgt ctctaaaaaa atagaaaaat    20820

ttgccctgca tggtggctca cgcctgtaat cctagccctt tggaaggcca aggcgggcag    20880

atcacttgag gtcgggagtt cgagaccagc ctgaccaaca tggagaaacc ccatctgtac    20940

taaaaataca aaattagctg ggtttggtgg cgcatgcttg taatcccagc tactcgggag    21000

gctgaggcag gagaatcgct tgaacccagg aggcggaggt tgcagtgagc tgagatcgcg    21060

ccattgcact ccagcctggg caacaacagt gaaactccgt ctcaaaaaaa aaagaaaaaa    21120

aaattcaaca ttttattttg agaaatttca aacctacaaa aagttgcagg aatagtgtct    21180

atctgaaata catattcagt cttttcttta gaagtctttt tttttttttt ttttttaaat    21240

agagcctcac tctgtcaccc aggctggagt gcagtggcgc gatctgtaaa atcactgtga    21300

gcactgactt agcacatact ggaccgttgc tcctaggaga aatacagggt tgcgttcctg    21360

tgagctttgg tcgtgatatt ttcatcagct gatcaatatg taatcttgtt ttatgtgtat    21420

ttctgtttaa agattcatat atatatgtgt atatatatat atggttgagt tgttaccgtt    21480

gaactcacag cccacaggac tagaacacat gcctaaataa agtttatcta acatacttgt    21540

tttctccata tgtatatcca tcataacctt cttgcactga ggaatattag ataatatata    21600

tatgtattta tgtattatac atatatatat atattttttt ttttgagaca gagttttgct    21660

cttgttgccc aggctggagt gcaagggcac gatctctgct cactgcaacc tccaccttct    21720

ggtttctttc ttttgtttga aacaaagttt taccttgttg cccaggctcc agtgcagcgg    21780

cacaatctca gcttactaca gcctttgcct cccaggttca agtgattctc ctgcctcagc    21840

ctcttgagta gctaggatta caggcatgca ccaccatgcc cagctgattt ttgtgttttt    21900

agtagagacg gggttttacc acgttggcca ggctggtctc gaactcctga cctcaagcta    21960

tccacccgcc tgggcctccc aaagtgctgg gattacaggc atgagccact gcgcccagcc    22020

caccttctgg tttccagcga ttctcctgcc tcagcctcct gaatacttgg gattacaggc    22080

accggctacc acacccggct aatttttttg tatttttagt agaggcaggg gtttcgctgt    22140

gtgggccagg ctggtctgga actcgacccc gttatccacc caccttggcc tcccaaagtt    22200

ctgggattac aggcgtgagc cactggaccc ggcctattat tatatatata tattttgaaa    22260

cagtctcact ccatccccca ggctggagtg cagtggcaca atctctgatc acatgcagct    22320

tccgcttcct aggttcaagt gattcttctg cctcagcctc ccaagtagct agaatcacag    22380

gagcgcgcca ccacacccag caaatttttg tatttttagt agacgggatt tcaccatgtt    22440

ggccgggctg gtctcgaac                                                 22459


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic reverse DNA primer for VH amplification

<400>  5
cccttgacca ggcatcccag                                                   20


<210>  6
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic reverse DNA primer for VH amplification

<400>  6
cttgccattg agccagtcct ggtgcatgat gg                                     32


<210>  7
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic reverse DNA primer for VL amplification

<400>  7
gctctagact aacactcatt cctgttgaag ctcttg                                 36


<210>  8
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic reverse DNA primer for VL amplification

<400>  8
gttgttcaag aagcacacga ctg                                               23


<210>  9
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  9

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Arg Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly His Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Leu Cys 
                85                  90                  95      


Gly Arg Gly Gly Thr Thr Val Val Val Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  10
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  10

Ser Tyr Trp Met Asn 
1               5   


<210>  11
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  11

His Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  12
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  12

Gly Gly Thr Thr Val Val Val Asp Tyr 
1               5                   


<210>  13
<211>  354
<212>  DNA
<213>  Mus musculus

<400>  13
caggttcagc tgcagcagtc tggggctgag ctggtgaggc ctgggtcctc agtgaagatt       60

tcctgcaagg cttctggcta tgcattcagg agctactgga tgaactgggt gaagcagagg      120

cctggacagg gtcttgagtg gattggacat atttatcctg gagatggtga tactaactac      180

aatggaaagt tcaagggtaa agccacactg actgcagaca aatcctccag cacagcctac      240

atgcagctca gcagcctaac atctgaggac tctgcggtct atttgtgtgg aaggggaggt      300

actacggtag tagttgacta ctggggccaa ggcaccactc tcacagtctc ctca            354


<210>  14
<211>  15
<212>  DNA
<213>  Mus musculus

<400>  14
agctactgga tgaac                                                        15


<210>  15
<211>  51
<212>  DNA
<213>  Mus musculus

<400>  15
catatttatc ctggagatgg tgatactaac tacaatggaa agttcaaggg t                51


<210>  16
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  16
ggaggtacta cggtagtagt tgactac                                           27


<210>  17
<211>  114
<212>  PRT
<213>  Mus musculus

<400>  17

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg 
        


<210>  18
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  18

Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr 
1               5                   10      


<210>  19
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  19

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  20
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  20

Lys Gln Ser Tyr Asn Leu Pro Trp Thr 
1               5                   


<210>  21
<211>  342
<212>  DNA
<213>  Mus musculus

<400>  21
gacattgtga tgtcacagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcact       60

atgagctgca aatccagtca gagtctgctc aacagtagaa cccgaaagaa ctacttggct      120

tggtaccagc agaaaccagg gcagtctcct aaactgctga tctactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgcaggctga ggacctggca gtttattact gcaagcaatc ttataatctt      300

ccgtggacgt tcggtggagg caccaagctg gaaatcaaac gg                         342


<210>  22
<211>  33
<212>  DNA
<213>  Mus musculus

<400>  22
aaatccagtc agagtctgct caacagtaga acc                                    33


<210>  23
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  23
tgggcatcca ctagggaatc t                                                 21


<210>  24
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  24
aagcaatctt ataatcttcc gtggacg                                           27


<210>  25
<211>  304
<212>  PRT
<213>  Mus musculus

<400>  25

Met His Pro Glu Pro Ala Pro Pro Pro Ser His Ser Asn Pro Glu Leu 
1               5                   10                  15      


Pro Val Ser Gly Gly Ser Ser Thr Ser Gly Ser Arg Arg Ser Arg Arg 
            20                  25                  30          


Arg Ser Gly Asp Gly Glu Pro Ser Gly Ala Pro Pro Leu Pro Pro Pro 
        35                  40                  45              


Pro Pro Ala Val Ser Tyr Pro Asp Trp Ile Gly Gln Ser Tyr Ser Glu 
    50                  55                  60                  


Val Met Ser Leu Asn Glu His Ser Met Gln Ala Leu Ser Trp Arg Lys 
65                  70                  75                  80  


Leu Tyr Leu Ser Arg Ala Lys Leu Lys Ala Ser Ser Arg Thr Ser Ala 
                85                  90                  95      


Leu Leu Ser Gly Phe Ala Met Val Ala Met Val Glu Val Gln Leu Asp 
            100                 105                 110         


Thr Asp His Asp Tyr Pro Pro Gly Leu Leu Ile Val Phe Ser Ala Cys 
        115                 120                 125             


Thr Thr Val Leu Val Ala Val His Leu Phe Ala Leu Met Ile Ser Thr 
    130                 135                 140                 


Cys Ile Leu Pro Asn Ile Glu Ala Val Ser Asn Val His Asn Leu Asn 
145                 150                 155                 160 


Ser Val Lys Glu Ser Pro His Glu Arg Met His Arg His Ile Glu Leu 
                165                 170                 175     


Ala Trp Ala Phe Ser Thr Val Ile Gly Thr Leu Leu Phe Leu Ala Glu 
            180                 185                 190         


Val Val Leu Leu Cys Trp Val Lys Phe Leu Pro Leu Lys Arg Gln Ala 
        195                 200                 205             


Gly Gln Pro Ser Pro Thr Lys Pro Pro Ala Glu Ser Val Ile Val Ala 
    210                 215                 220                 


Asn His Ser Asp Ser Ser Gly Ile Thr Pro Gly Glu Ala Ala Ala Ile 
225                 230                 235                 240 


Ala Ser Thr Ala Ile Met Val Pro Cys Gly Leu Val Phe Ile Val Phe 
                245                 250                 255     


Ala Val His Phe Tyr Arg Ser Leu Val Ser His Lys Thr Asp Arg Gln 
            260                 265                 270         


Phe Gln Glu Leu Asn Glu Leu Ala Glu Phe Ala Arg Leu Gln Asp Gln 
        275                 280                 285             


Leu Asp His Arg Gly Asp His Ser Leu Thr Pro Gly Thr His Tyr Ala 
    290                 295                 300                 


<210>  26
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-linked glycosylation site where X can be any amino acid except 
       proline


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa can be any amino acid except proline

<400>  26

Asn Xaa Ser 
1           


<210>  27
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-linked glycosylation site where X can be any amino acid except 
       proline


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa can be any amino acid except proline

<400>  27

Asn Xaa Thr 
1           


<210>  28
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  28

His Ile Tyr Pro Gly Asp Gly Asp Thr 
1               5                   


<210>  29
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic variant CDRH2

<400>  29

His Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Ala Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  30
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic variant CDRH2

<400>  30

His Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  31
<211>  39
<212>  PRT
<213>  Mus musculus

<400>  31

Trp Val Lys Phe Leu Pro Leu Lys Lys Gln Pro Gly Gln Pro Arg Pro 
1               5                   10                  15      


Thr Ser Lys Pro Pro Ala Ser Gly Ala Ala Ala Asn Val Ser Thr Ser 
            20                  25                  30          


Gly Ile Thr Pro Gly Gln Ala 
        35                  


<210>  32
<211>  28
<212>  PRT
<213>  Mus musculus

<400>  32

Gly Gln Pro Arg Pro Thr Ser Lys Pro Pro Ala Ser Gly Ala Ala Ala 
1               5                   10                  15      


Asn Val Ser Thr Ser Gly Ile Thr Pro Gly Gln Ala 
            20                  25              


<210>  33
<211>  19
<212>  PRT
<213>  Mus musculus

<400>  33

Pro Ala Ser Gly Ala Ala Ala Asn Val Ser Thr Ser Gly Ile Thr Pro 
1               5                   10                  15      


Gly Gln Ala 
            


<210>  34
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  34

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly His Ile Tyr Pro Gly Asp Ala Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ser Arg Gln Leu Gly Phe Arg Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  35
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  35

His Ile Tyr Pro Gly Asp Ala Asp Thr Asn Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  36
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  36

Gln Leu Gly Phe Arg Tyr Ala Met Asp Tyr 
1               5                   10  


<210>  37
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  37

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  38
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  38

Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  39
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  39

Lys Gln Ser Tyr Asn Leu Arg Thr 
1               5               


<210>  40
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  40

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Phe Phe Cys 
                85                  90                  95      


Ala Arg Val Ser Arg Phe Ala Val Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  41
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  41

Asp His Arg Asp Tyr Tyr Ala Met Asp Tyr 
1               5                   10  


<210>  42
<211>  114
<212>  PRT
<213>  Mus musculus

<400>  42

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Glu Ser Gly Thr Asn Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asp Leu Thr Arg Ser Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg 
        


<210>  43
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  43

Lys Gln Ser Tyr Asp Leu Thr Arg Ser 
1               5                   


<210>  44
<211>  19
<212>  PRT
<213>  Mus musculus

<400>  44

Arg Asp Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr 
1               5                   10                  15      


Val Ser Ser 
            


<210>  45
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  45

Asp Thr Met Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Phe Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Ser Gln 
                85                  90                  95      


Ser Tyr Asn Leu Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
            100                 105                 110         


Arg 
    


<210>  46
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  46

Lys Ser Ser Gln Ser Leu Phe Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  47
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  47

Ser Gln Ser Tyr Asn Leu Arg Thr 
1               5               


<210>  48
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  48

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly His Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Gly Arg Leu Arg Phe Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  49
<211>  21
<212>  PRT
<213>  Mus musculus

<400>  49

His Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      


Gly Lys Ala Thr Leu 
            20      


<210>  50
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  50

Ser Gly Arg Leu Arg Phe Ala Met Asp Tyr 
1               5                   10  


<210>  51
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  51

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Gln 
            100                 105                 110         


Arg 
    


<210>  52
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sythetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X= Any Amino Acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X= Any Amino Acid

<400>  52

Xaa Ile Tyr Pro Gly Asp Xaa Asp Thr Asn Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  53
<211>  98
<212>  PRT
<213>  Mus musculus

<400>  53

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg 
        


<210>  54
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X= Any Amino Acid

<400>  54

Lys Ser Ser Gln Ser Leu Xaa Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  55
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = Lys or Ser

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X = Asn or Asp

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X = Pro, Thr, or Null

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X = Trp or Arg

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X = Thr or Ser

<400>  55

Xaa Gln Ser Tyr Xaa Leu Xaa Xaa Xaa 
1               5                   


<210>  56
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = Any Amino Acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X = Any Amino Acid

<400>  56

Xaa Ile Tyr Pro Gly Asp Xaa Asp Thr Asn Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      


Gly Lys Ala Thr Leu 
            20      


<210>  57
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X = Any Amino Acid

<400>  57

Lys Ser Ser Gln Ser Leu Xaa Asn Ser Arg Thr 
1               5                   10      


<210>  58
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  58

Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  59
<211>  100
<212>  PRT
<213>  Mus musculus

<400>  59

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu 
            100 


<210>  60
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  60

Lys Gln Ser Tyr Asn Leu 
1               5       


