                         SEQUENCE LISTING

<110>  CSL Ltd
       McKenzie, Brent
       Maraskovsky, Eugene
 
<120>  METHOD OF TREATING INFLAMMATORY BOWEL DISEASE

<130>  512820

<150>  US 61/579555
<151>  2011-12-22

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  435
<212>  DNA
<213>  homo sapiens

<400>  1
atgtggctgc agagcctgct gctcttgggc actgtggcct gcagcatctc tgcacccgcc       60

cgctcgccca gccccagcac gcagccctgg gagcatgtga atgccatcca ggaggcccgg      120

cgtctcctga acctgagtag agacactgct gctgagatga atgaaacagt agaagtcatc      180

tcagaaatgt ttgacctcca ggagccgacc tgcctacaga cccgcctgga gctgtacaag      240

cagggcctgc ggggcagcct caccaagctc aagggcccct tgaccatgat ggccagccac      300

tacaagcagc actgccctcc aaccccggaa acttcctgtg caacccagat tatcaccttt      360

gaaagtttca aagagaacct gaaggacttt ctgcttgtca tcccctttga ctgctgggag      420

ccagtccagg agtga                                                       435


<210>  2
<211>  127
<212>  PRT
<213>  homo sapiens

<400>  2

Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His Val 
1               5                   10                  15      


Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp Thr 
            20                  25                  30          


Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe Asp 
        35                  40                  45              


Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys Gln 
    50                  55                  60                  


Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met Met 
65                  70                  75                  80  


Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser Cys 
                85                  90                  95      


Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys Asp 
            100                 105                 110         


Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
        115                 120                 125         


<210>  3
<211>  1203
<212>  DNA
<213>  Homo sapiens

<400>  3
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg       60

atcccagaga aatcggatct gcgaacagtg gcaccagcct ctagtctcaa tgtgaggttt      120

gactccagga cgatgaattt aagctgggac tgccaagaaa acacaacctt cagcaagtgt      180

ttcttaactg acaagaagaa cagagtcgtg gaacccaggc tcagtaacaa cgaatgttcg      240

tgcacatttc gtgaaatttg tctgcatgaa ggagtcacat ttgaggttca cgtgaatact      300

agtcaaagag gatttcaaca gaaactgctt tatccaaatt caggaaggga gggtaccgct      360

gctcagaatt tctcctgttt catctacaat gcggatttaa tgaactgtac ctgggcgagg      420

ggtccgacgg ccccccgtga cgtccagtat tttttgtaca tacgaaactc aaagagaagg      480

agggagatcc ggtgtcctta ttacatacaa gactcaggaa cccatgtggg atgtcacctg      540

gataacctgt caggattaac gtctcgcaat tactttctgg ttaacggaac cagccgagaa      600

attggcatcc aattctttga ttcacttttg gacacaaaga aaatagaacg attcaaccct      660

cccagcaatg tcaccgtacg ttgcaacacg acgcactgcc tcgtacggtg gaaacagccc      720

aggacctatc agaagctgtc gtacctggac tttcagtacc agctggacgt ccacagaaag      780

aatacccagc ctggcacgga aaacctactg attaatgttt ctggtgattt ggaaaataga      840

tacaactttc caagctctga gcccagagca aaacacagtg tgaagatcag agctgcagac      900

gtccgcatct tgaattggag ctcctggagt gaagccattg aatttggttc tgacgacggg      960

aacctcggct ctgtgtacat ttatgtgctc ctaatcgtgg gaacccttgt ctgtggcatc     1020

gtcctcggct tcctctttaa aaggttcctt aggatacagc ggctgttccc gccagttcca     1080

cagatcaaag acaaactgaa tgataaccat gaggtggaag acgagatcat ctgggaggaa     1140

ttcaccccag aggaagggaa aggctaccgc gaagaggtct tgaccgtgaa ggaaattacc     1200

tga                                                                   1203


<210>  4
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  4

Leu Ile Pro Glu Lys Ser Asp Leu Arg Thr Val Ala Pro Ala Ser Ser 
1               5                   10                  15      


Leu Asn Val Arg Phe Asp Ser Arg Thr Met Asn Leu Ser Trp Asp Cys 
            20                  25                  30          


Gln Glu Asn Thr Thr Phe Ser Lys Cys Phe Leu Thr Asp Lys Lys Asn 
        35                  40                  45              


Arg Val Val Glu Pro Arg Leu Ser Asn Asn Glu Cys Ser Cys Thr Phe 
    50                  55                  60                  


Arg Glu Ile Cys Leu His Glu Gly Val Thr Phe Glu Val His Val Asn 
65                  70                  75                  80  


Thr Ser Gln Arg Gly Phe Gln Gln Lys Leu Leu Tyr Pro Asn Ser Gly 
                85                  90                  95      


Arg Glu Gly Thr Ala Ala Gln Asn Phe Ser Cys Phe Ile Tyr Asn Ala 
            100                 105                 110         


Asp Leu Met Asn Cys Thr Trp Ala Arg Gly Pro Thr Ala Pro Arg Asp 
        115                 120                 125             


Val Gln Tyr Phe Leu Tyr Ile Arg Asn Ser Lys Arg Arg Arg Glu Ile 
    130                 135                 140                 


Arg Cys Pro Tyr Tyr Ile Gln Asp Ser Gly Thr His Val Gly Cys His 
145                 150                 155                 160 


Leu Asp Asn Leu Ser Gly Leu Thr Ser Arg Asn Tyr Phe Leu Val Asn 
                165                 170                 175     


Gly Thr Ser Arg Glu Ile Gly Ile Gln Phe Phe Asp Ser Leu Leu Asp 
            180                 185                 190         


Thr Lys Lys Ile Glu Arg Phe Asn Pro Pro Ser Asn Val Thr Val Arg 
        195                 200                 205             


Cys Asn Thr Thr His Cys Leu Val Arg Trp Lys Gln Pro Arg Thr Tyr 
    210                 215                 220                 


Gln Lys Leu Ser Tyr Leu Asp Phe Gln Tyr Gln Leu Asp Val His Arg 
225                 230                 235                 240 


Lys Asn Thr Gln Pro Gly Thr Glu Asn Leu Leu Ile Asn Val Ser Gly 
                245                 250                 255     


Asp Leu Glu Asn Arg Tyr Asn Phe Pro Ser Ser Glu Pro Arg Ala Lys 
            260                 265                 270         


His Ser Val Lys Ile Arg Ala Ala Asp Val Arg Ile Leu Asn Trp Ser 
        275                 280                 285             


Ser Trp Ser Glu Ala Ile Glu Phe Gly Ser Asp Asp Gly Asn Leu Gly 
    290                 295                 300                 


Ser Val Tyr Ile Tyr Val Leu Leu Ile Val Gly Thr Leu Val Cys Gly 
305                 310                 315                 320 


Ile Val Leu Gly Phe Leu Phe Lys Arg Phe Leu Arg Ile Gln Arg Leu 
                325                 330                 335     


Phe Pro Pro Val Pro Gln Ile Lys Asp Lys Leu Asn Asp Asn His Glu 
            340                 345                 350         


Val Glu Asp Glu Ile Ile Trp Glu Glu Phe Thr Pro Glu Glu Gly Lys 
        355                 360                 365             


Gly Tyr Arg Glu Glu Val Leu Thr Val Lys Glu Ile Thr 
    370                 375                 380     


<210>  5
<211>  2694
<212>  DNA
<213>  Homo sapiens

<400>  5
atggtgctgg cccaggggct gctctccatg gccctgctgg ccctgtgctg ggagcgcagc       60

ctggcagggg cagaagaaac catcccgctg cagaccctgc gctgctacaa cgactacacc      120

agccacatca cctgcaggtg ggcagacacc caggatgccc agcggctcgt caacgtgacc      180

ctcattcgcc gggtgaatga ggacctcctg gagccagtgt cctgtgacct cagtgatgac      240

atgccctggt cagcctgccc ccatccccgc tgcgtgccca ggagatgtgt cattccctgc      300

cagagttttg tcgtcactga cgttgactac ttctcattcc aaccagacag gcctctgggc      360

acccggctca ccgtcactct gacccagcat gtccagcctc ctgagcccag ggacctgcag      420

atcagcaccg accaggacca cttcctgctg acctggagtg tggcccttgg gagtccccag      480

agccactggt tgtccccagg ggatctggag tttgaggtgg tctacaagcg gcttcaggac      540

tcttgggagg acgcagccat cctcctctcc aacacctccc aggccaccct ggggccagag      600

cacctcatgc ccagcagcac ctacgtggcc cgagtacgga cccgcctggc cccaggttct      660

cggctctcag gacgtcccag caagtggagc ccagaggttt gctgggactc ccagccaggg      720

gatgaggccc agccccagaa cctggagtgc ttctttgacg gggccgccgt gctcagctgc      780

tcctgggagg tgaggaagga ggtggccagc tcggtctcct ttggcctatt ctacaagccc      840

agcccagatg caggggagga agagtgctcc ccagtgctga gggaggggct cggcagcctc      900

cacaccaggc accactgcca gattcccgtg cccgaccccg cgacccacgg ccaatacatc      960

gtctctgttc agccaaggag ggcagagaaa cacataaaga gctcagtgaa catccagatg     1020

gcccctccat ccctcaacgt gaccaaggat ggagacagct acagcctgcg ctgggaaaca     1080

atgaaaatgc gatacgaaca catagaccac acatttgaga tccagtacag gaaagacacg     1140

gccacgtgga aggacagcaa gaccgagacc ctccagaacg cccacagcat ggccctgcca     1200

gccctggagc cctccaccag gtactgggcc agggtgaggg tcaggacctc ccgcaccggc     1260

tacaacggga tctggagcga gtggagtgag gcgcgctcct gggacaccga gtcggtgctg     1320

cctatgtggg tgctggccct catcgtgatc ttcctcacca tcgctgtgct cctggccctc     1380

cgcttctgtg gcatctacgg gtacaggctg cgcagaaagt gggaggagaa gatccccaac     1440

cccagcaaga gccacctgtt ccagaacggg agcgcagagc tttggccccc aggcagcatg     1500

tcggccttca ctagcgggag tcccccacac caggggccgt ggggcagccg cttccctgag     1560

ctggaggggg tgttccctgt aggattcggg gacagcgagg tgtcacctct caccatagag     1620

gaccccaagc atgtctgtga tccaccatct gggcctgaca cgactccagc tgcctcagat     1680

ctacccacag agcagccccc cagcccccag ccaggcccgc ctgccgcctc ccacacacct     1740

gagaaacagg cttccagctt tgacttcaat gggccctacc tggggccgcc ccacagccgc     1800

tccctacctg acatcctggg ccagccggag cccccacagg agggtgggag ccagaagtcc     1860

ccacctccag ggtccctgga gtacctgtgt ctgcctgctg gggggcaggt gcaactggtc     1920

cctctggccc aggcgatggg accaggacag gccgtggaag tggagagaag gccgagccag     1980

ggggctgcag ggagtccctc cctggagtcc gggggaggcc ctgcccctcc tgctcttggg     2040

ccaagggtgg gaggacagga ccaaaaggac agccctgtgg ctatacccat gagctctggg     2100

gacactgagg accctggagt ggcctctggt tatgtctcct ctgcagacct ggtattcacc     2160

ccaaactcag gggcctcgtc tgtctcccta gttccctctc tgggcctccc ctcagaccag     2220

acccccagct tatgtcctgg gctggccagt ggaccccctg gagccccagg ccctgtgaag     2280

tcagggtttg agggctatgt ggagctccct ccaattgagg gccggtcccc caggtcacca     2340

aggaacaatc ctgtcccccc tgaggccaaa agccctgtcc tgaacccagg ggaacgcccg     2400

gcagatgtgt ccccaacatc cccacagccc gagggcctcc ttgtcctgca gcaagtgggc     2460

gactattgct tcctccccgg cctggggccc ggccctctct cgctccggag taaaccttct     2520

tccccgggac ccggtcctga gatcaagaac ctagaccagg cttttcaagt caagaagccc     2580

ccaggccagg ctgtgcccca ggtgcccgtc attcagctct tcaaagccct gaagcagcag     2640

gactacctgt ctctgccccc ttgggaggtc aacaagcctg gggaggtgtg ttga           2694


<210>  6
<211>  881
<212>  PRT
<213>  Homo sapiens

<400>  6

Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Thr Ile Pro Leu Gln Thr 
1               5                   10                  15      


Leu Arg Cys Tyr Asn Asp Tyr Thr Ser His Ile Thr Cys Arg Trp Ala 
            20                  25                  30          


Asp Thr Gln Asp Ala Gln Arg Leu Val Asn Val Thr Leu Ile Arg Arg 
        35                  40                  45              


Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp 
    50                  55                  60                  


Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 
65                  70                  75                  80  


Val Ile Pro Cys Gln Ser Phe Val Val Thr Asp Val Asp Tyr Phe Ser 
                85                  90                  95      


Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu Thr Val Thr Leu Thr 
            100                 105                 110         


Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Thr Asp 
        115                 120                 125             


Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala Leu Gly Ser Pro Gln 
    130                 135                 140                 


Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 
145                 150                 155                 160 


Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Thr 
                165                 170                 175     


Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met Pro Ser Ser Thr Tyr 
            180                 185                 190         


Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 
        195                 200                 205             


Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 
    210                 215                 220                 


Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 
225                 230                 235                 240 


Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 
                245                 250                 255     


Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu 
            260                 265                 270         


Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Thr Arg His 
        275                 280                 285             


His Cys Gln Ile Pro Val Pro Asp Pro Ala Thr His Gly Gln Tyr Ile 
    290                 295                 300                 


Val Ser Val Gln Pro Arg Arg Ala Glu Lys His Ile Lys Ser Ser Val 
305                 310                 315                 320 


Asn Ile Gln Met Ala Pro Pro Ser Leu Asn Val Thr Lys Asp Gly Asp 
                325                 330                 335     


Ser Tyr Ser Leu Arg Trp Glu Thr Met Lys Met Arg Tyr Glu His Ile 
            340                 345                 350         


Asp His Thr Phe Glu Ile Gln Tyr Arg Lys Asp Thr Ala Thr Trp Lys 
        355                 360                 365             


Asp Ser Lys Thr Glu Thr Leu Gln Asn Ala His Ser Met Ala Leu Pro 
    370                 375                 380                 


Ala Leu Glu Pro Ser Thr Arg Tyr Trp Ala Arg Val Arg Val Arg Thr 
385                 390                 395                 400 


Ser Arg Thr Gly Tyr Asn Gly Ile Trp Ser Glu Trp Ser Glu Ala Arg 
                405                 410                 415     


Ser Trp Asp Thr Glu Ser Val Leu Pro Met Trp Val Leu Ala Leu Ile 
            420                 425                 430         


Val Ile Phe Leu Thr Ile Ala Val Leu Leu Ala Leu Arg Phe Cys Gly 
        435                 440                 445             


Ile Tyr Gly Tyr Arg Leu Arg Arg Lys Trp Glu Glu Lys Ile Pro Asn 
    450                 455                 460                 


Pro Ser Lys Ser His Leu Phe Gln Asn Gly Ser Ala Glu Leu Trp Pro 
465                 470                 475                 480 


Pro Gly Ser Met Ser Ala Phe Thr Ser Gly Ser Pro Pro His Gln Gly 
                485                 490                 495     


Pro Trp Gly Ser Arg Phe Pro Glu Leu Glu Gly Val Phe Pro Val Gly 
            500                 505                 510         


Phe Gly Asp Ser Glu Val Ser Pro Leu Thr Ile Glu Asp Pro Lys His 
        515                 520                 525             


Val Cys Asp Pro Pro Ser Gly Pro Asp Thr Thr Pro Ala Ala Ser Asp 
    530                 535                 540                 


Leu Pro Thr Glu Gln Pro Pro Ser Pro Gln Pro Gly Pro Pro Ala Ala 
545                 550                 555                 560 


Ser His Thr Pro Glu Lys Gln Ala Ser Ser Phe Asp Phe Asn Gly Pro 
                565                 570                 575     


Tyr Leu Gly Pro Pro His Ser Arg Ser Leu Pro Asp Ile Leu Gly Gln 
            580                 585                 590         


Pro Glu Pro Pro Gln Glu Gly Gly Ser Gln Lys Ser Pro Pro Pro Gly 
        595                 600                 605             


Ser Leu Glu Tyr Leu Cys Leu Pro Ala Gly Gly Gln Val Gln Leu Val 
    610                 615                 620                 


Pro Leu Ala Gln Ala Met Gly Pro Gly Gln Ala Val Glu Val Glu Arg 
625                 630                 635                 640 


Arg Pro Ser Gln Gly Ala Ala Gly Ser Pro Ser Leu Glu Ser Gly Gly 
                645                 650                 655     


Gly Pro Ala Pro Pro Ala Leu Gly Pro Arg Val Gly Gly Gln Asp Gln 
            660                 665                 670         


Lys Asp Ser Pro Val Ala Ile Pro Met Ser Ser Gly Asp Thr Glu Asp 
        675                 680                 685             


Pro Gly Val Ala Ser Gly Tyr Val Ser Ser Ala Asp Leu Val Phe Thr 
    690                 695                 700                 


Pro Asn Ser Gly Ala Ser Ser Val Ser Leu Val Pro Ser Leu Gly Leu 
705                 710                 715                 720 


Pro Ser Asp Gln Thr Pro Ser Leu Cys Pro Gly Leu Ala Ser Gly Pro 
                725                 730                 735     


Pro Gly Ala Pro Gly Pro Val Lys Ser Gly Phe Glu Gly Tyr Val Glu 
            740                 745                 750         


Leu Pro Pro Ile Glu Gly Arg Ser Pro Arg Ser Pro Arg Asn Asn Pro 
        755                 760                 765             


Val Pro Pro Glu Ala Lys Ser Pro Val Leu Asn Pro Gly Glu Arg Pro 
    770                 775                 780                 


Ala Asp Val Ser Pro Thr Ser Pro Gln Pro Glu Gly Leu Leu Val Leu 
785                 790                 795                 800 


Gln Gln Val Gly Asp Tyr Cys Phe Leu Pro Gly Leu Gly Pro Gly Pro 
                805                 810                 815     


Leu Ser Leu Arg Ser Lys Pro Ser Ser Pro Gly Pro Gly Pro Glu Ile 
            820                 825                 830         


Lys Asn Leu Asp Gln Ala Phe Gln Val Lys Lys Pro Pro Gly Gln Ala 
        835                 840                 845             


Val Pro Gln Val Pro Val Ile Gln Leu Phe Lys Ala Leu Lys Gln Gln 
    850                 855                 860                 


Asp Tyr Leu Ser Leu Pro Pro Trp Glu Val Asn Lys Pro Gly Glu Val 
865                 870                 875                 880 


Cys 
    


