                         SEQUENCE LISTING

<110>  Chen, Guokai
       Thomson, James
       Hou, Zhonggang
 
<120>  FGF-2 Having Enhanced Stability

<130>  960296.01479

<150>  US 61/576,824
<151>  2011-12-16

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala Leu Pro Glu Asp Gly 
1               5                   10                  15      


Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys Asp Pro Lys Arg Leu 
            20                  25                  30          


Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile His Pro Asp Gly Arg 
        35                  40                  45              


Val Asp Gly Val Arg Glu Lys Ser Asp Pro His Ile Lys Leu Gln Leu 
    50                  55                  60                  


Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys Gly Val Cys Ala Asn 
65                  70                  75                  80  


Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu Leu Ala Ser Lys Cys 
                85                  90                  95      


Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu Glu Ser Asn Asn Tyr 
            100                 105                 110         


Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser Trp Tyr Val Ala Leu Lys 
        115                 120                 125             


Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr Gly Pro Gly Gln Lys 
    130                 135                 140                 


Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
145                 150                 155 


<210>  2
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of FGF-2 K128N

<400>  2

Met Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala Leu Pro Glu Asp Gly 
1               5                   10                  15      


Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys Asp Pro Lys Arg Leu 
            20                  25                  30          


Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile His Pro Asp Gly Arg 
        35                  40                  45              


Val Asp Gly Val Arg Glu Lys Ser Asp Pro His Ile Lys Leu Gln Leu 
    50                  55                  60                  


Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys Gly Val Cys Ala Asn 
65                  70                  75                  80  


Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu Leu Ala Ser Lys Cys 
                85                  90                  95      


Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu Glu Ser Asn Asn Tyr 
            100                 105                 110         


Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser Trp Tyr Val Ala Leu Asn 
        115                 120                 125             


Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr Gly Pro Gly Gln Lys 
    130                 135                 140                 


Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
145                 150                 155 


<210>  3
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   Amino acid sequence of FGF-2 K128D relative to wild type FGF-2

<400>  3

Met Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala Leu Pro Glu Asp Gly 
1               5                   10                  15      


Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys Asp Pro Lys Arg Leu 
            20                  25                  30          


Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile His Pro Asp Gly Arg 
        35                  40                  45              


Val Asp Gly Val Arg Glu Lys Ser Asp Pro His Ile Lys Leu Gln Leu 
    50                  55                  60                  


Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys Gly Val Cys Ala Asn 
65                  70                  75                  80  


Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu Leu Ala Ser Lys Cys 
                85                  90                  95      


Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu Glu Ser Asn Asn Tyr 
            100                 105                 110         


Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser Trp Tyr Val Ala Leu Asp 
        115                 120                 125             


Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr Gly Pro Gly Gln Lys 
    130                 135                 140                 


Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
145                 150                 155 


<210>  4
<211>  465
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence encoding the amino acid sequence shown for 
       SEQ ID NO:2.

<400>  4
atggcggcgg gcagcattac caccctgccg gcgctgccgg aagatggcgg cagcggcgcg       60

tttccgccgg gccattttaa agatccgaaa cgcctgtatt gcaaaaacgg cggctttttt      120

ctgcgcattc atccggatgg ccgcgtggat ggcgtgcgcg aaaaaagcga tccgcatatt      180

aaactgcagc tgcaggcgga agaacgcggc gtggtgagca ttaaaggcgt gtgcgcgaac      240

cgctatctgg cgatgaaaga agatggccgc ctgctggcga gcaaatgcgt gaccgatgaa      300

tgcttttttt ttgaacgcct ggaaagcaac aactataaca cctatcgcag ccgcaaatat      360

accagctggt atgtggcgct gaaccgcacc ggccagtata aactgggcag caaaaccggc      420

ccgggccaga aagcgattct gtttctgccg atgagcgcga aaagc                      465


